<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C669</accession>
    <name>A0A1C1C669_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C669"/>
    <dbReference type="STRING" id="86049.A0A1C1C669"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00091"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02024"/>
    <dbReference type="eggNOG" id="ENOG502RZSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650592" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="211"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="402" mass="43294" checksum="82EA7F91EF60D7E1" modified="2016-11-02" version="1">MQLPPLFSGLASLITLATAQSDSSQVLVVDQRSFNVLRPVPPPSQSNLTTIFVPPGITLEEALDKPFHVYDDAFYDIIGPNPTLTVLASQGTNPLFHEAVVWYPPTDEVFFVQNAGAAAAGTGLNKSNIIQKIALSQAAAVSSMRNASGQVRVQTVNATPPVINSNGATLYRGQLLFTGEGQGNNTAPALYVMNPEPPYNTSILVNNYFGRQWNSLNDVAVNPRNGDVYFTDTLYGYLQDFRPSPELPNQVYRFNPSTGAVTTVADGFELPNALRDHPTPVLVRASVRKDVLTDDLRSAPSFQYTVLEDGTWSNRKLFSYVSPGIPDGVHCDTDGNVYSGVGDGVVVYNPSGTLLGKIFLGTTSANFNFAGKGRMVICAETELYYATLAAEGAVVQSEMPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6U8</accession>
    <name>A0A1C1C6U8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6U8"/>
    <dbReference type="STRING" id="86049.A0A1C1C6U8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00678"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01118"/>
    <dbReference type="eggNOG" id="ENOG502S2AG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2118965at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703:SF1">
        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="317" mass="34350" checksum="43AE4C3AFE6CE8F4" modified="2016-11-02" version="1">MEAARAAVQKLTGNRGHHTSVEETVVPAVTHEAVKPHRHEEATQAVDREVHQHHYHTTVQPLAHQERLPEKHTHNILPAEHREFHHDDESATKERIAAEMANFKSHSTTHETVHTQAAAPTVTGEHVHHHVHETVVPVVHKETIQPEVVHTTIPVHETHHAAAQHHGLSALPMKTLDEFKAAGGALVGGHHSSHEEYEGAPRPYNDKLATTFDKLEEKFHGGHHSTGTTTGTTGIGDHNKTHRPTDSGVGGVGNDLTSGGIGRDHHHQENGSSVGDKHLGARGAGPMGTTEGAKPSLADRMNPRVDADGDGKRGFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C774</accession>
    <name>A0A1C1C774_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polysaccharide export protein (CAP59)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C774"/>
    <dbReference type="STRING" id="86049.A0A1C1C774"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05914"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07056"/>
    <dbReference type="eggNOG" id="ENOG502RJAT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT44360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="49163" checksum="832C8D12B2CB970D" modified="2016-11-02" version="1">MLRRSYRRSSLPRRLVRLLLYLLGALFVLDVLTILKHHREFSRNLVSHTYTSSAVLPTPVRDQKIYIVAQFWTNARVISERWGQALLDLVDVLGKENVYVSILESGSLDNTKEVLKQLDDVLVQNNIPHVTILDPTTHADEINAGPLDEQGTPRQGWIQTTTVGTQWGKELRRIPYLARLRNRALGPLFKFHDEQGPKFDKVLFLNDVVFRPQDVLTLLATNQGSFSAACALDFHLPPAYYDTFALRDSEGLGTIQSTFPYFRGIDSRETMLKGMPTKVSSCWNGMIVMDSAPFYEGLRFRALSDSLASKHLEASECCLIHTDMNVTIPGAGQRIYVNPSVRVGYTVDAYNITHSGPEENFVSATQYVTGVWTNRLRRTVLPRETKTMKDVERKMARWVKEGENSLEKREENGAICAIDEQHILIWNGWKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7Q7</accession>
    <name>A0A1C1C7Q7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7Q7"/>
    <dbReference type="STRING" id="86049.A0A1C1C7Q7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05814"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07180"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="502" mass="56827" checksum="CD406862D5DCAD59" modified="2016-11-02" version="1">MLYGHLTVPEQDPNSRDIAPPNEQDAPYPGNGASQAPDLFLDFIYNGSPDEVQENNTYEAPMSWLQAIGPWRRRHPSLDLAMSAILNMVRLEGDSGDERLQREGVAKYGRALKDVQNILASDRLALEELTLASCMILAIFEACHPVLLYACPAANGERIGDGTLGRERLWMGEPCRRYLEAIPASRSSAACRRPEPPSVLGLSTHRRKCVRVSIPPLSLGARTAAHCPSQIIHALALRKPTYLAEPDWLTIPWTRQSKTDFHHLLDIMAQVPIFIDQTERVHKVSPSDMSGGKRWELLEQGWELHRQLKDWYQELTRRVSEPFYIERRCSLSWPDPVPRTDLGNGFPTFLHFQTFQIARMHLFYWTTLLLLYDNILRTMPASLEPTKLDSASASTSLRMTDKAAIRRQALDVATLIARSMEFLLSKERFLGSEEMQIRGLLNTPFPLRTAIHVFASAQQHAMESWCRSVFDGLAQRGYPFGQILCGWHWDDIPVFLAGACPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C868</accession>
    <name>A0A1C1C868_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_06123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C868"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06123"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04568"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF281">
        <property type="entry name" value="ASPYRIDONES EFFLUX PROTEIN APDF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="61"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT44652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="267" mass="29256" checksum="77538A13183F290D" modified="2016-11-02" version="1">MTTQSDIHRAGLSNEKVARESPNHSPPTGEGAADHGTEQKNEDTTRATPSEVSFPEGGLRAWLVVLGSSILLGCSFGWLSSFGTFQSYYETHQLLDESPSTISWIGSTQTFTQYFVGLISGNLFDLYGARVLIIPGMMVYIFSILMTSLCHEYYQFLLAQGLLCGLAVGFIFTPATSVVGHYFRSRRGLAMGFITAGSSLGGILLPIALKNGLYSHTLRFTWTIRTVGFVLLILMAIACALVKERLPSRPRHLFVFEAFRIPAIPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8T4</accession>
    <name>A0A1C1C8T4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_05384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8T4"/>
    <dbReference type="STRING" id="86049.A0A1C1C8T4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05384"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07623"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000576">
        <property type="entry name" value="C2H2 transcription factor (AmdX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="120"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="942"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="944"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT44953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1167" mass="126852" checksum="A0BBB39313EBA91C" modified="2016-11-02" version="1">MTVASPEGTASEAMDVAGSDIGKSAQENSSRPGSASHSRGSASKPPSIAGSTGSNAASNPAQILPKTDKPRPHVCTTCMRSFARLEHLKRHERSHTKEKPFECPECTRCFARRDLLLRHQQKLHSSTTPSARPRSGRRESVAGVASGRVRKNSTAGNAGTMRPRANTLSHVDSAILGLLSNSTGNFGRQYMSGHNHSSSMNVLSGPQAFAYRSLHSNQAPFNLPKLETHGLPIDLSGGLRTAPPFGGFGSEFGGGFGPDQGDTINPHALHMTDLHGLGLDPMGSPFQQMFPGMTASQAMADDESGFDWMTQGFENQMSFAQAHENAIDDSSPSAMSTNSPAPANDVHNEANMVLMQQSSATAGNMWSNALESQVPVLNSPMSVDMMSAFNEVVNVPMETISPKSLLGRGSSMDMSLPTPPDFVSMDASAMQANPRYSGFQLSFTAEAPASTTSTASMDSSLRQGSATSASSELVSDRIRNVLIAGLSQNAGFGQRKYSQPAISSPLSPSSTVRPRGFNPSTFPSTHELQRYVSAYIRYFHPHLPFLHIPTLNFEAPEFTTPIRLVSGNSQLSHTTVAGGASCLILSIAAIGALYEGEVSQSRELFECAKRLISNYLEERRKANMTKTQFAPRHATEREDTPLWLVQAMLLNVIYGHNCGDKTAAELASNHCAALVSLARGAELARPSQGHTGTGSNDVNGHPHMNGMAANGWNSVMNEVDNSDWIEWKLVEERKRTLYAVFILSSMLVTAYNHPPALTNSEIRLNLPCDEELWAAESAPLWRNLGGTSGPEAHAVTFAASLTHLLTSAHRQRRRNSNVTALGITGEPDLRPSTFGCLILVNALHNYIWETRQRHLGREWTTSETEQMHAHIEPALRAWQAAWASNPSHSLERPNPFGAGPLSADCIPLLDLAYVRLFVNFGRSKEAFWQRDYDAMAEELAKGSAVSSGRETANTNLGKNFSSNNKHDQWGQQQMPSPAEEIMKIEPRETKPEGRHSQSSQRERHLRKAAFYAADSLSVSEKLGLSFAERPSRELPTQSAMCAFDCAQVVAEWIAAVQERVGKYLGVIGRDNMNLVDVPGILLLEDEDRKLIQRIDEVLNSAEQKLESQGGFDLAAAREGGHGSRILTLTAYILERDSVWPVYKLMARSLRTQAGHIQERALASVAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8X6</accession>
    <name>A0A1C1C8X6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8X6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06148"/>
    <dbReference type="OrthoDB" id="4156995at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650649" evidence="3">
        <location>
            <begin position="21"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="239" mass="26068" checksum="3ACFE0450B7C2F58" modified="2016-11-02" version="1">MACQLLFPLILLTLTPCSLAIIVTVPTDGATYNSSPGPRWIEWQQEPGDPSECDIWLQKEGGNATYFAHVAVPPCRYDFSSWPTALSSNGSRSIETGEYCFTFTTPKSRAEQGQFLTESAHFLIKEEQPAQPLSPGAKAGIGIGVGVVGLAFIALCYHMFRQEGRRYKKTVPTQTPFSKPELDGIQGAKPTARSELSADMEKEPPFEVMASHPVLHELPGSSHQPLEAEGSTKKSSRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C934</accession>
    <name>A0A1C1C934_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C934"/>
    <dbReference type="STRING" id="86049.A0A1C1C934"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05355"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07669"/>
    <dbReference type="eggNOG" id="ENOG502QQ7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5332281at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="749"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="860"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1271"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1338"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1362"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1448"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1494"/>
            <end position="1503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1518" mass="163162" checksum="13FB55A755DC63FF" modified="2016-11-02" version="1">MEPSRPGGYLSIPITDAERAQAARARDDSSERLLADTRHSSPESRDPSPDFRPPPVAQLQVPFPSRFPSIHAAPIARQFAPSFQPRIDDSQYHQISPVPEEDEPESIKLRPYTAVAEEDDSRLLPPVFPGPTPPLWTPLWLKKWFLGLFALVFAGFLVALVLLWYYDGQNDGFHVDQGTSHYAWAYTPTIIVVFVVAAWRMVDHHAKLAMPYDALQNGPTKTSESLLVDYISKFQLVALFEAFKNSHFAVITSITGFVLLKVVTVFATGLLLALPTQVTLKGSSLQANGFDAASFNPNSALDSSSSVTQPVYAYHGSMAQGMPLENGVTLRLAYSAISVTSDTPIDGDVTISGEVDAFVPTMSCEAVDAQLTTPRIVNDTNSASAFATSSNITFNIPAGGVCGKLSSVTVPADNPFTEILPQRQVTGTMQQVFCGTANASVPDAAGPQGLLFTITDIAYQQALFDNATDLAGGSFTIASDVSRTLTNLTNVFCRPSYVMTKAQFINNTQLLDSSQAALIELKDGGTNGTLEGFSDWNATNVLSQASMAAQVLFSDTINDDTISDSSAIFMLMALTRGSRDVDTLINPSVMMQAATDTYQGILSQYAHLNLRATDNSDVVGGKVTRQEQRLRVNDVSVWTMASASGLLFLFCIALIFIAPRAVVPRDPSSIAAVATTLARSTELNRLLRKQGAPGYANQKTALTGYEFGTAIATTDSGRASFKIVVSEGELDEPATQPTMDLKWWRPLTATFPAVIITVILPVGAIVALELIQRNSDEHSGFYTVAEDKWTEVYSHYIPGLVMLILAALVNMLDFNVALFTPWNNLASGGAVHRKSILNNILGRSPPFAFLQALRTGSLGAMLSIAATAVASILTVIASGLYYVQHYSVDGPTISLTQTDSFALTWADSFSNDNGAGAMMNLLMHQNFSYPQFTYEGLVFPKLVLNNSALTTDTLTTATGSASHLLPAVRANLRCDVMSSDSFSVSTQAAGSGSGYATDQAFVTVRANLPDSCHLGGTSGTDDFFLYENNFELPSGGKGTYAGAQLDLLFGENATTYGNYGERRGQYIGDNPPVGCPSLAFTFGHFQLDGNDKSQVTTMICYQEIQGLSANVTLRPNSTTIDPNQPPVVQENSVFLHENPLANNSGVNTFDFRIQNNLAQEMTVFNGGGGTPATNPSSTTTYDIFFQAIINGTAPHEPASLAGPDNQDVLVDAITRFYQIYMAQAISANMRGPVNSLSDSSRVLRRQSSSLTTTSPTTIDTPRLVQDMDSKLILQVLLGIMAALSASAYLLTKFHRVLPCNPCSIAGTMSLLAGSDLVHSTDDGLCECCGKPRRRSFGADLTNRPESIHARPEETGGTHGEGEGEGEGEEVDDREQIIDDGAEWFSTTQFEGVFAGKRYSMGWWRERPALGKRRRYGVDVGIRADGSDDQDWELGSRRPRDAGFSGFMDHPKLRGDRDGRGGYARGSDREPSPGVGVYSYVPDEARTGARFQSDGPGGGGGGPGPATMAARSSPLGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9C1</accession>
    <name>A0A1C1C9C1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative WD repeat-containing protein C17D11.16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_05730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9C1"/>
    <dbReference type="STRING" id="86049.A0A1C1C9C1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05730"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07720"/>
    <dbReference type="eggNOG" id="KOG0270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000457">
        <property type="entry name" value="rRNA processing protein Pwp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="278"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="415"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="516"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT45048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="558" mass="61792" checksum="9F3511698398298C" modified="2016-11-02" version="1">MSMTLATTWVRRGVAAQFPQKYQVDEAELSRISKLARLQLEDAQQDLLDAQNGKDVDVDNNSEDSDSEAGVATSEVSGKAKTPVTEEDDLKEYNLDDYDDDPVDEQGEKFSMFGNVGSLAYHAPHEQDPYIVLPEGEQDSEDEREDLQILASDNLILAAKVEDEVAQLEVFVYEDEADNLYVHHDIMLPAVPLCVEWINVPVGKGSESRSEGNFVAIGTMNPEIEVWDLDVVDSMYPNAILGQEPEEQPDTEQNGEGSSSKTNKKKSKKKKKKPKANEEYHVDAVLALAANRHHRNLLASASADKTVKLWDLNTGKCAKSYTMHSGKVCALDWHPTESTILLSGSYDRTVIATDMRAPDAQAPKWVVEADVEKVRWDIHDPNFFYVTTEAGTVHYFDARVVPSSHDKPSKPVWTLQAHDGAVSAFDINPTVPGLLATGSDDKKVKLWNVQDNKPNMVISRNLDVGRIFATQFAPDTEVAFRLSVAGSKGRLQVWDISTNPSVRKVFAGRVQLPESDGKERLVGASLSDHESDDDEDEEEEGNADRAGGQDGWESMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9F4</accession>
    <name>A0A1C1C9F4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PQ loop repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_05895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9F4"/>
    <dbReference type="STRING" id="86049.A0A1C1C9F4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05895"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07823"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT45163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="445" mass="49036" checksum="CD624F2046801A37" modified="2016-11-02" version="1">MALAYIPFRELALPDHCTPTTPLLSSLSSQLGICVPTPLAALSTLLGTLSIVSWLFAQMPQIFKNYQIKSTAGLSIFFLGEWLLGDLTNLLGAVFTKQAGWQIIIASYYVFVDLCLVIQYFWYSHVAKWVYEESLHSSGSSDIDDADSAIINGLSPINTQFADDGPLLRDAGDPSSKRSTPTNTNAPLFSSVSYGEKKAAGPQDIIYGDKMASSWIASPSPRTLLYAATMSSLASNVAAAPVPFPSDHYVHGIHLLRVDTPLEIVGTILSWCSTLLYLGSRLPQLYKNWQRQSTAGLSPLLFFAAFCGNFFYSASMITNPNAWADYGPHGHHGWVDADGNQRWAWVARAAPFFLGAAGVLFMDAMMGVQFMLYGEEEERIVKVRDSHGYSHWERVSGWMRGWIPSIAGKDKVVDLAQSQRLLNESGHLTISRRRSHHHVGYGTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9F5</accession>
    <name>A0A1C1C9F5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">catA</name>
        <name evidence="17" type="ORF">CLCR_05504</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9F5"/>
    <dbReference type="STRING" id="86049.A0A1C1C9F5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05504"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07824"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1370.20:FF:000001">
        <property type="entry name" value="Catalase HPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="16">
        <location>
            <begin position="50"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT45164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="762" mass="85128" checksum="A90873C31EA575B8" modified="2016-11-02" version="1">MQKMATTVSNTLRDIGNSAAGAVEGAVHNKKIADLEKNKKNQHDTKQNTTTDWGAKVSDGDHAVKIVDEKGNHVGPTLLEDEVFRERNTYTDDGQIHRFDHERIPERVVHARGAGAHGTFKLFESCEDVTSAGVLTDTSRTTPIFVRFSTVQGSRGSADTVRDVRGFALKFYTDEGNWDIVANDIPVFFIQEAIKFPDLVHSLKPEPDNEVPQGQTAHNNFWDFAFLHKEATHMLFWAMSDRGIPRSYRMIQGFGVNTFVMINAKGERTFVKFIWTPELGVHSLVWDEALKLAGQDPDFHRKDLWEAIENGAYPKWKFGFQAIKDGDQDKFDFDILDATKVWPEELVPIRYVGELELNRNIDEYFAETEQVAFCTSHIVPGIDFSEDPLLQGRNFSYQDTQLSRLGVNWEELPINRPVCPVLNFNRDGQGRHTISKGKANYWPNRFEANPPTGQGGKGGLESFPATYPGVKARRLTPKWKEYLSQAQLFFNSMSEIEKKHIIEAFSFELDHCDDDIVYERMVTRLAEIDLSLAQAVAQNAGAKSPEAQLQPNHGKKAKGLSQFDYMPKEPTIKGRRVAILIADGFDLGAYEAMKAAVFAQSAVPWTIGVKRQAMKSADGSKEVKADHFINGQRSTMFDALFIPGGAESIKTFKKMGLARFWVKEAFGHLKAIGAVGEGVDLVHAALTEVENVKLAGAGAGADGVVNWYGVVTAADAQAGSIIKEAVKISKDTKDFAGQFFWEMSQHRNFFRELDGYAEQVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAD8</accession>
    <name>A0A1C1CAD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gda1</name>
        <name evidence="11" type="ORF">CLCR_05713</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAD8"/>
    <dbReference type="STRING" id="86049.A0A1C1CAD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05713"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08056"/>
    <dbReference type="eggNOG" id="KOG1385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="295"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT45428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="572" mass="62988" checksum="C960C5696B012532" modified="2016-11-02" version="1">MSSSPKPLDRAGIWSYVPFTSAPRRRSIGSGLPRTTTNTANGRPWDPSAAKSNTHFLPSGRSQPNILESVQNAWMTQSRQAKYIRTGGILALIVLLYWFMSAGSTPVQNVYTSTTSPTSRCTKPHDPTKPLVQYAIMIDAGSTGSRIHVYKFNNCGPTPELENEDFKMTEPKPGGSGLSSFKTDAEGAAKSLDPLMEVAMKAVPDEYKSCTPIAVKATAGLRLLGEDMSLKILEAVRTRLETQYPFAVVSREKNGVEIMKGEDEGVFAWITTNYLLGKIGGPDESPTAAVFDLGGGSTQIVFQPTFKKSPHGGMPQTMEEGDHKYKLKFGGREFELYQHSHLGYGLMSARKALHQLVLDRMHKQNPDSRAWLSKPIPNSCITPGTQKKITVEMPADHELAGEHEVVMEGPADAIPAQCRALAEAILYKDKACNLAPCSFNGVHQPPLEKTFAKEDVYIFSYFYDRTHELGMPESFTLRELQDLTAKACGGEKTWDAFAGIEGAIEGLQERPETCLDLNFMSALLHTGYEMPIDREVKIAKKIKGNELGWCLGASLPLLEKESGWECRIREVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAF3</accession>
    <name>A0A1C1CAF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">High-affinity glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HGT1</name>
        <name evidence="11" type="ORF">CLCR_05624</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05624"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08076"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="60"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT45448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="570" mass="64074" checksum="C92CD03C0A3CCA12" modified="2016-11-02" version="1">MAAVDQHTNKRSHNAEDGDYVSGVTDPRGIETEDSVVELRDTYVKPGLRGTFQSKYVVLCAFVVRLGGFLFGYDQGVVSVILVMDQFLDQFPRVSETASGAGFWKGFMTAMIELGALIGAFNQGWIAEKISRKYSICVAVSIFVVGSVLQTAAQNYAMLVVGRLIGGVGVGMLSMVVPMYIAEVSPPEIRGTLLVLEEFSIVFGIICAYWLTFGTRYINSQWSFRLPFLLQIIPAIVLGIAVLFIPFSPRWLVSKGRDREALAALVKLRRVPADDPRLQAEWYDIRAEVAFHKEVAQKRHPELGLQGRRSRLSAIKLELTAYADCFRQGYWRRTMVGIGLMFFQQFVGINALIYYSPSLFESMNVTYNMRLVLSGVLNVTQLVGVSTSLYTMDRFGRRPLLLIGSVFMTVSHAIIAVLVGLYYGNWDDHKDKGWVAVAFLFLYMLAFGCTWGPVPWAMPSEIFPSFLRAKGVAWSTCSNWLNNFIIGLITPPLVQNTRGFGAYTFFAVFCALSFLWTWFCVPETRGRSLEDMDQVFGDRAAVSDRVRRKEILQELRQEGGHWGQERMEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAG8</accession>
    <name>A0A1C1CAG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06008"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08085"/>
    <dbReference type="OrthoDB" id="188042at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48173">
        <property type="entry name" value="GNK2-HOMOLOGOUS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48173:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="375" mass="40987" checksum="15BAE8591C530215" modified="2016-11-02" version="1">MSIAAGDHHIYTDAIAVQPQVVQSSVRGLVTPTAISTTAEPLTLKQIETLIGKYGPVLNLHPDEKFFNTSVEDFLNHSELIEVIDKKAKKTKSLGKPTAANLPQTGKDSQYYLQLNEDGKKGDLSAAKAYVRAFWQPGMPYTDLQFWFFNAYNGPGTLHIDGLVMDSITSSGDINVSPLGEHVGDWEMCMVRVNNTTLNLDSIWLSQHSKGQFFTADQIGRAFKFQGTQPIIFSSRNGHANFSRAGSNPTESRKIGGIPAGFSFFVRNDTAVSNYKLDCSKDYELVSADFAGVKSPSWLTYPFRWGPEGTSTRISPVTVAEIVEAAAGDELTKFLPFAAGVVLAGEILPHFVKGDINGPTPPSRHGSWMGIYPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAZ5</accession>
    <name>A0A1C1CAZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative WSC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_01539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAZ5"/>
    <dbReference type="STRING" id="86049.A0A1C1CAZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01539"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03626"/>
    <dbReference type="eggNOG" id="ENOG502QW32">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF7">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650691" evidence="2">
        <location>
            <begin position="27"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="42"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="490" mass="53083" checksum="AFFA666E2153D20D" modified="2016-11-02" version="1">MATMRVKLKTSLMLLVSLFFICPANAFFRHLCHGELGNGRVDPIVAPGNPSQHLHVIFGASSKFDHHWCQTGTLTTVADMGLEPTLEELLASNCTSCSILQDHSVYWTPRMYFQHANGTLEMIPTSGGLTVYYFTERDPVFQDPVTAFPQNFRMVAGNSMKRAFLGPNPDPPMSNWNASDKSQPALMEKALGFNCLNYGAQPEGARQYHYLRDKPFLDAQCTDGIRAEVMFPSCWNGKDLDSEDHTSHVAYPHEVQNGQCPDGYPVRLPTLFYETIYQTNLFAGMGGQFTFSNGDPTGYGYHGDFMCAWDAGVLQSAIDSPACNLPQQASGNQDDCPIFDLQEVDAGTQCKMETPEILQNEPINLIQQLPGNVQIQAGPGSATMGPAPGATAPAARPAPTANSTALSTPAVPTPGPTASMSTSPPATTLSPCTSKSQHTTTTAFMSNGVMINLVLVEEVVTVTVSDGPSAVARVHRRGHKRKHGHQDGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB50</accession>
    <name>A0A1C1CB50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_01479</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB50"/>
    <dbReference type="STRING" id="86049.A0A1C1CB50"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01479"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03603"/>
    <dbReference type="eggNOG" id="KOG2542">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT45706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="634" mass="71904" checksum="549B7EEA48C5E275" modified="2016-11-02" version="1">MSSHTNGANGHANGHHKIENTSTTTLADIPKSHIFTSKLPADPQFPTPLDSHRAPRQKLGPRMVRSALFTYVRPEPTEEPELLAVSKAALRDIGLAESEAESEELKQVVAGNKIYWDEDKPEEGVYPWAQCYGGFQFGSWAGQLGDGRAMSLFETTNPDTGVRYEVQLKGAGKTPYSRFADGKAVLRSSIREFVVSEYLNTIGIPTTRALSLTLCPKSEVVRERLEPGAIVCRFAQSWVRFGTFDLLRSRGDRELTRTLATYVAEEVFGGWENLPAALPSLEDNKDAHLDPARNVPKDAIQGKEGAEENRFTRLYREITRRTALLVGKLQAYGFMNGVLNTDNTSILGLSLDYGPFAFMDNFDPAYTPNHDDHMLRYSYRAQPSVFWWNLVRLGEALGELIGAGDRVDDEIFATKGVEEEFAPVLIKRAETIIDQCSDEYKAVFLSEYRRLMTARLGLRTQKESDFEKLFSELLDTMEALELDFNHFFRRLSSVKMSDVDTKEGREQTAERFFHHGGVTGLNETNESGREKIGAWLDQWRQRIVEDWDTSGEDADSQRCESMRRVNPNFVPRGWLLDDIIDRVQNKKERDILKGVMEMTLHPFEDGWGWNEDVEEKYCGDVPRFRRAIQCSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB75</accession>
    <name>A0A1C1CB75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_01606</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB75"/>
    <dbReference type="STRING" id="86049.A0A1C1CB75"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01606"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03609"/>
    <dbReference type="eggNOG" id="KOG4245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF30">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="91"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT45711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="363" mass="41330" checksum="6B8D87963D503D0D" modified="2016-11-02" version="1">MGDEQSQPTNASNLEAHHPSQSPSTASFRKTARLICLEEHAVSPFPVPSTSSTFNIFKPTYISGVKERLSNIAHRIAVMDAHNIGAQIISMNQPTAQAFTDLQQQVEWCRKSNDFVVENYCRAYPNRFFAFATLPTQSGRAAAEELERCVKEYGFVGAMINGFNNTTDPTRGLYLDDSQFDALWETAERLQKPIFIHPRVPLVSNMKVLEDMPVFHGAPYGFGRETCEHILRIMYAGVFDRFPKLKVCLGHMGEGLSWILPRTDSTFRLYSAEAQGPKKKRFQEYFQQNILPNTSGMPRTSALMQLMAESKAENIMFAVDYPYESVAEMRAWFETVPVSDETWRDIGYRNAIRWFGLPLDYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBA9</accession>
    <name>A0A1C1CBA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_01523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBA9"/>
    <dbReference type="STRING" id="86049.A0A1C1CBA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01523"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03636"/>
    <dbReference type="eggNOG" id="KOG1111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03814">
        <property type="entry name" value="GT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="5">
        <location>
            <begin position="61"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="4">
        <location>
            <begin position="251"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT45742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="540" mass="60357" checksum="0094A21D083EB7F7" modified="2016-11-02" version="1">MAVEEDDARGELESRTAATPPALGSQLQSSSLTLTSEKRDGFPAFLKGKRVLLATESLGPVNGVSRTTLMLIEHLRKNGVQLAIVAPHSRQSRLKPATGAGLTEFRLPGYELPYNPDLTVVYPFQLDEVYKHTFKPDIVYLASPASTGFQMLFQIRQLQDPPVVLLNFQTDLSAYSEILFPGPVARFSVWLLGVVQGFLFNHRSVHTIFYPSSGVRRYLEKAGAPGNKMVRLGRGVDTSLFDPSRRDDGYRKELAPNGEMILVCVCRLAPEKGFEFLAQVAMRLARDGFPFKLLIVGGNMSAEVEDEVHHLFDDVKDHVVFTGFRTGVDLARAYATGDVFLHCSITETFGLVVLEAMASGLPVIARDEGGPSDIILHGETGYLVPPHDLEQYIALIKGLRSDKDLHSDMAVAARRYTCDVTWEKINQRVAWQMTDGLRQHLQRKQRRRPIRNFIVARYQGVRDGLVIPAIVQIRLYLAAMVVYIIWFMTAFVLLCYGHRVFSRAAQLLRNPPLVLQRLQYRALPALKHGIKETLKGLTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBC5</accession>
    <name>A0A1C1CBC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBC5"/>
    <dbReference type="STRING" id="86049.A0A1C1CBC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01427"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03743"/>
    <dbReference type="eggNOG" id="ENOG502RZ8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5376804at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="801" mass="87227" checksum="01C148AA8666247D" modified="2016-11-02" version="1">MAQDQTVSGNTGDAHLPHDGDPTHKDDTPPTAQRAVEPDSQSHPAGDGSDNQDPFPGTAQDGPQNHHQNSASDVETQEHPQVVDNATSDSEAQPPLPPVSPSPVPRKPVAKAVVVTNGAEIPDRRLAKAPAQSARDLGGFWHNWWSEMTFLILMFGAFAAIVAVIAPYQHRRLPSWPYSITINALIAVFTVILRGSILFIATKTLSQQKWIWFGGPHARPLFDLSRFDNASRGPWGSFLLVLSLHGRSLLATLGALITVLTIAIDPFAQQVVHYYSCSQASTGTNATMPRTGLFQEAGSVQLRVNANTVTPGLASAINAGVFSAEAAKRITSDCPSGNCQFSEPYHTLGYCSNCSDISDQVKVTNFDVPYTFLNQTSIIQALNTSLPSGYSTQYVTFENATYLVTGVLDPSVIESGTNAPSPFAITHEKDFQILYGAYTDDNANSGMEHPTCSEAEKHHAQTAWGCRGYGAAQCSLVPCIRTYEAAISNGTVDETLISTSRDWGYSYRVSKASVYVPCLSAQQKRALKDQGYPITDSMVWLPYDHNIDPSTGMWELNATHGTNQSATDIVPPKCLYEFFFLAMTSINEYLQSQIFNGTVTAYGSDGRAAFTSTNPVVAAIYNGGNISFPHVESLFENISLAMTSYIRQNSNGTYLGRYFQVSNTSISFDPNFLAQGTMYQQDTCVEVRWPWLILPGTLAVLTALFLCATIIETSLARPSNASLKDGSAAERGNPAGILPRRRAAVWKESLLPLLFHGLDAKVVEEHNTSGLTPIDELEKWARTLNVRMDNGDQGWKFVKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBK3</accession>
    <name>A0A1C1CBK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stress response protein YvgO</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBK3"/>
    <dbReference type="STRING" id="86049.A0A1C1CBK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01733"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03742"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650683" description="Stress response protein YvgO" evidence="1">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19284" checksum="F280971212DEB2A5" modified="2016-11-02" version="1">MHLPSFLYFLAWISTFFGTSISAPTKNVHHPARPVSEASVDRRQLQVLVDVAVIITAAETVIEGIQTLIDLIDGDIEEAEGQFTRGIVSNLRDQYPTMNVLVYHNQDCGYDLYDATHAHVEFDIALGFTKGYEVWVFDHGTFNLVGDGGYQNWAIGGSFDGPSSEVTFYSMNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBN5</accession>
    <name>A0A1C1CBN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_00050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000018">
        <property type="protein sequence ID" value="OCT45886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBN5"/>
    <dbReference type="STRING" id="86049.A0A1C1CBN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00050"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00041"/>
    <dbReference type="eggNOG" id="ENOG502QPT5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="7">
        <location>
            <begin position="46"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="8">
        <location>
            <begin position="301"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT45886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="475" mass="53157" checksum="78524D083406A5B5" modified="2016-11-02" version="1">MAASKSWWEESPSREPSPEQPTFESKPLADSDVPDTNEEQLLTRRVHILGLGSIGTLAAHSLRCLPNPPPITLMIHRSEQYEAFKRGGRVISLINKQNEINDQQTGYDVDLFEGIHEDGSARWRFIPDAPYHKPRTNPIEPGEEMPSGELFIYTLVVAVKGPTTVSALRSVKHRVNAKTTICFMQNGLGQIDELNQAVFTDPETRPTYMLGIVSHGAYMSQPCTVVHAGYGTVALGICRDRDRYPLPPKGPVRHLWELSEDERKKYHPTDKELFSSLSSRYLLRTLTRSPVLACAVFPYLDLLQLQLEKLASNCILNPLTALLDVPNGAILDNDELRPIQRLLLAEISLVIRGLPELEGIPNVRHRFSAKRLEQLFLGVTKRTAQNSSSMREDIRRDKQPEIDYINGYIVKRGEQQGIKCALNFMLMQLIKGKHSLRGGAALPYGTTRVVTDADADRPALVTISDESTPARGRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBT5</accession>
    <name>A0A1C1CBT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_00532</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBT5"/>
    <dbReference type="STRING" id="86049.A0A1C1CBT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00532"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10045"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT45965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="139" mass="15739" checksum="8FDBCA385FFEA475" modified="2016-11-02" version="1">MAEATRSKAAKSKSKSKEPYYAVSPLWKDVVPVPLIDRPPGQKDAGPALATIAYSPRYSEAMSYLRAVMAVNEFSRRALDLTEDIIGMNPAHYTVWLYRAKILKTLWQTEGTTVEDGVTTELDWLEGISERNLKNYQIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCR1</accession>
    <name>A0A1C1CCR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-arabonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">araC</name>
        <name evidence="9" type="ORF">CLCR_01119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCR1"/>
    <dbReference type="STRING" id="86049.A0A1C1CCR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01119"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09212"/>
    <dbReference type="eggNOG" id="KOG2448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004784">
        <property type="entry name" value="PRK06131.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="7">
        <location>
            <begin position="71"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="8">
        <location>
            <begin position="400"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT46320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="633" mass="67697" checksum="A332C8E60A9F8EA6" modified="2016-11-02" version="1">MTTNDNGPAANGQNGDSHTSIAADYDLSRPIDSTSGLRAGLTSYGDAHFSLFLRKVFIKALGYSDAALSSPIVGIINTYSSFNPCHSNVPQLIESVKRGVLASGGLPVDFPTISVHESFSSPTSMYLRNLMSMDTEEMIKAQPVDAVVMIGGCDKTVPAQLMGGISANKLMLPLITGPMMPGSVEGVRVGACTDCRSYWARYRAGNVDLEDIMSVNEELAPTGGTCGVMGTASTMACITAGLGLIELKSGATAAAVSSARLRVAEQAGRDAVAMLKRDGMKPQDLLTRESFLNAITVLQAIGGSTNAVVHLMAIINRHPKVAGTIDLKTFDDIGRTTPLLVDLKPSGDNYMTDFHNAGGMLALLHTLRPLLHLNAKTYTGQSLGELLDSTPFKSFSYSRQIIRSLEDPLYPSSSLLVLYGNICPDGAVMKASASKNRNLLQHRGSACVFENSADMARRIDSPDLEVDENSILILKSIGPVGNPGMPEAGLIPIPQKLGKQGVADMLRISDGRMSGTAGGTIILHISPESADLDSVFGIVQTGDKIVCDVENRKLLLEVDDQEIARRIAERKRQSQSDSSSSRQAGDKASRRVEPWLERSGRRGYRGLYEREVNQAHEGCDFGFLTAKGPSKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD80</accession>
    <name>A0A1C1CD80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_01862</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Noorani M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD80"/>
    <dbReference type="STRING" id="86049.A0A1C1CD80"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01862"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01204"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF3">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="350"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="554"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT46473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="680" mass="75861" checksum="52773B7DA061246D" modified="2016-11-02" version="1">MASDSNMLLSRHIQNMSEAKSLQPHWGYADRALPCTNDPGSCEYLDVVYHSHDLGMLYCGIIWATIGGTLLIWTIGTRLFPPVDQDQSRFLIAESQGTDNKHHIHRLKDALAALSRQYLLPESLRAIFGRTTRLQVLVLLTLTGYLTVFSFVGIEYHTWVTPVKNMAGVNNTRTSLGPWSDRVGVLAYALTPLSVLLSSRESLLSLITGVPYQSFNFLHRWLGYIIFIQSALHTIGWCVVEMRLYQPQPTVGLEWIQQKYMIWGVLAMFFLTVLFVLSTPWAIRRTGYEFFRKCHYVMAMLYIGACWGHWSKLNCYLIPSLVVWFIDRGARLARTALLHYNYLPNGGMGFQAANATITRFPDPANGDVVRLDFVHPSGPWEVGQHFYLCFPEISIWQSHPFTPCSLPGTEPQGSVHSYILRAKKGATRAVADLAAAKTIASAHDSKVAATSAATTSVLLTGPYGRSIRDHLTPKTNVLCIAGGTGVTFVLPVLLGLIAQCPVPDRKLELVWAVRRDADLSWVGQELDQLRRSAVLHDMKIRLFVTRIGHADPGTHDLKQVEGLDSRPEDDRIQVSSASVSSASSHQVKKDKEATCVDALSIHHPSLPNPEPHNRRPDLTSITQEFLNATICGPTIVYASGPGEMVSDLRRIVAGCNSGGKVWKGRERYDVRLVCDDRMEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDB6</accession>
    <name>A0A1C1CDB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Trichodiene oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TRI4</name>
        <name evidence="11" type="ORF">CLCR_01911</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDB6"/>
    <dbReference type="STRING" id="86049.A0A1C1CDB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01911"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01250"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT46520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="516" mass="60040" checksum="25CDE21BE938E6D6" modified="2016-11-02" version="1">MSEGRVSERVRDFAQNVDYIRTVLLLICVWLTWQVLLFLYRLTIHPLARFPGPKLAAASYWYEYYYDVSKEGRFIWKIMELHEEYGPVVRINPNELHFNDPDFYEEIYHGKKYKTDRDKWFNLDHIGQGLAFTIDHDLHARRRNALSPYFSMQSIRALEPRITDVVAIMLDRIHEACQKGRTINLYHMFTAFAMDIVSEYALGKDLSMHFINHPDFGKEWAELTVAIRMNNFGRHFKGITAVLVSVPEFIMVRLNPRIGGFIDFHNILRKKVQQVLDEQGSEKAKDEPTTLFRELIKSDLPAEEKTLRRLTDEASMVLGAGGETTAQALVRTFYHLIENPRIIDKLRAELTVALPEPNTIPSLAALQNLPYLNAVVDEGVRISFPVPARSPRVFHDHTLLYDKWPIRPGTAVSMSPWMVMMSEKVFPDPFKFDPERWLGNKELRKYQVAFSKGRRACLGINLAYAEMLFAISTIIRNFELELFETTWEDVEIVHDFFLALPRFDSKGVRVKVKEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDU4</accession>
    <name>A0A1C1CDU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTPase activating protein for Arf</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_01829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDU4"/>
    <dbReference type="STRING" id="86049.A0A1C1CDU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01829"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01425"/>
    <dbReference type="eggNOG" id="KOG0703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000026">
        <property type="entry name" value="GTPase activating protein for Arf, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF7">
        <property type="entry name" value="ACTIVATING PROTEIN FOR ARF, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="4">
        <location>
            <begin position="34"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="238"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="488"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="555"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="733"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="835" mass="91611" checksum="C1D17F1A27BBB819" modified="2016-11-02" version="1">MSIVPSSFSPQGRSHVAELRMASSMSKRTQARNERELHQLLSVAGNSQCADCGAKNPAWASWNLGIFLCMRCASLHRKLGTHISKVKSLSMDTWTSEQVESMKRNGNNAVNKAYNPKNKKPDMPLDADEVDSAMERFIRKKYQEKSLADGKPQPPQRDDHSPTAYSPRPPLEDPDSPPPPVPTKKGKIFGFGLRASSSAYPFSKSDKKKKSQEPRVDSAFPIPTRGYDSRMDDARYEMTDAELERKLATLRDMGFTETERNANLLRRLNGNVERVVETLVRLGPRENGDPTSRQSTRSASAQAPPPTSRAPEPFYNPFTQSASQPTIGLSLGKPHEPSTPTSTTTFGSNNPFAPPDRTTTGLEQSFQSMQVSQQPQQALFPHSTGGYPSQPAPIQDPRSQYSMTPPVTSTQYQDFVASPPALPVPSNPFFQPASLSAQSTGNNPFLTQSQVPMSPSTNPFLNQGLNQPPQPPQRQVSLPASFNPFGIPPTQTSPGQQQQQQQQQFQPQDPFGTTPQQTTQQQNDPFQTQAAQQQAQPAGYQTAQSPFGFPNTHYAQAQPQAPPQQQAQGQTPQFLQQHQPSYQQQPEQQYPQQTQQQFQQFQHTPQQTGRHDKTSILALYNYPQLTSQRLASIPEPATEQQQPQQQQPQQQPQQQYQQQFSPTPSDPFGNLPSPKRSATMPVSLSNMHSAGGSGNRNPFMTNTNAATQNMSATVNPFGGGTSPFASPPPQPGPQAQTQPSPFGQAQAQQPQQQYAHRQQTNPFGHVQEIGHGFVPGGGLPGTTINYSQGQILSTQQRPAQGIAARHASSESMAVNNLDAGRHSPDAFASLSARYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE31</accession>
    <name>A0A1C1CE31_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_01966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE31"/>
    <dbReference type="STRING" id="86049.A0A1C1CE31"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01966"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01507"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650761" description="SET domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="127"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="416" mass="46046" checksum="E814232B70842713" modified="2016-11-02" version="1">MKLNAISLGVLSLCVSLVASLQQDELLQSSETVADPGHDRIQPVSDQEQEGSDSYFPWTHKPICTKDVDDTGDQFCVYTNASFSNGRGISIFTRPAIAQEFASLPPFQDPTALSSNGINLDSDTEDLPWYTASVPGKGMGIFASRPLQRGDLITAYTPCLVTHIGDLRFTDDREKMLRLAIDQLPPATRDAYLALAKVYDEPDVMAQDILKANGFDMKLGDLMHPAVFPEASRYNHACAPNAQYFLSASMLTHYVHAVRPIQKDEEITISYAPPLRLHADRQKHFQSIFQFTCTCPRCSRTVQESDKATQDIATLQWELSQGTAPGSVKKAEQLVDLYRAEGLDGFLDTAYGYAALAYNSVGGTRGAMKYAKLAAEATRLKYSVDEGVGVEKVREWEGMARDPMGHPSWRNRRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEB2</accession>
    <name>A0A1C1CEB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEB2"/>
    <dbReference type="STRING" id="86049.A0A1C1CEB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02139"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01521"/>
    <dbReference type="eggNOG" id="KOG3502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11353" checksum="EFF381330EC652A1" modified="2016-11-02" version="1">MDAAGKVPVKLVKVTRVLGRTGSRGGVTQVRVEFMDDTSRSIIRNVKGPVRERSKKTEIIVWTDGMLEMRIFEADMMVKTCTMIPKEMLHNFARVELAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEP9</accession>
    <name>A0A1C1CEP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cyp3</name>
        <name evidence="6" type="ORF">CLCR_02491</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEP9"/>
    <dbReference type="STRING" id="86049.A0A1C1CEP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02491"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02482"/>
    <dbReference type="eggNOG" id="KOG0879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="197" mass="21386" checksum="8192345C654C8825" modified="2016-11-02" version="1">MATSKIPVPRPGEGEPIVFFDVQLGGEPLGRIKMHLFANAVPRTAENFRQFCTGEHRGPAGKPMGYKGSKFHRVIKNFMIQGGDFLHSDGTGSTSIYNNAAFADESFAIKHTRPYLLSMANSGPNTNGCQFFITCAATPWLDNKHVVFGQVLGEEDDGGESIRVVRMIENTRTAGPGGRGAGERPVLDVRIVECGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEZ7</accession>
    <name>A0A1C1CEZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02692"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="80" mass="8807" checksum="C9DC014C804A6FEE" modified="2016-11-02" version="1">MNYASVVVTFFATCRHVLDRGLATSTRSSLRFSALEYAASKDVESLPVDETVPETPIDRMSNHVSELLQTTGKQDEEDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF78</accession>
    <name>A0A1C1CF78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF78"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02682"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="79" mass="8228" checksum="79F08AAA1F1628C5" modified="2016-11-02" version="1">MRRRRNQVDGVRRPPQWNTEGALDVIGTVSKDEEGWGEGGLGTAVIAAGTLEIWSLALGAAAVRPPCGGVWAVGCGRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFT6</accession>
    <name>A0A1C1CFT6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">INH1</name>
        <name evidence="8" type="ORF">CLCR_03728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFT6"/>
    <dbReference type="STRING" id="86049.A0A1C1CFT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03728"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01994"/>
    <dbReference type="eggNOG" id="ENOG502SCJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5532350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417:SF1">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="106" mass="11896" checksum="AAACA8E04B90C51F" modified="2016-11-02" version="1">MLRMQVVKLARAGAAPSIRRSFSISAIQAAEGDTGAIRSGGVASGDSWTKREQANETKFIREKEMESLRKLKEKLAQQRKHLDELDKHIQELEGDAGEDPQHIREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFX0</accession>
    <name>A0A1C1CFX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-binding cassette transporter abc4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">abc4</name>
        <name evidence="13" type="ORF">CLCR_02225</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFX0"/>
    <dbReference type="STRING" id="86049.A0A1C1CFX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02225"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02070"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001577">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001751">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="957"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1032"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1150"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="233"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="618"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="940"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1231"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT47366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1449" mass="161374" checksum="74BB2E7145AA1998" modified="2016-11-02" version="1">MAAKPNIGNSRMRLPWPRPFIEEPVGCLGIGSKESSPRWHALCLIILSASGFVAQILVALSVAWASTTSALWALAVVYVIACRPRTASILLFVDLVGVFIAGACLLATVFYHNLNGRNAVLTFASTALAAIAIAVVVNMPLRDPSLRRAAISRPFSAPSSAFRSPEDNLTLLQWMTVSWIGPLLRVGNRRQLNDEDVWLLPYEFQHRLLHDTFRELRGSVVRRLLKANWIDLVLLTLLAIIELAANYSAPVILQKLLQAMESIDIEKRSAIQWALLILAVRLVAAQSAVFSLWFGRRCYERSRGEMITMLYEKTLNRKILGGIPQQAEMNFGPEEENPPDASEAEETGDLPETEQLLPQHAQRPKSPASRTQERFNKLKSFFVPKRRSEVERKTPASMGKILNLFRNDAYEVAQRFWEFQTLINKPLGLVLSVVLIWQLLGWPSFVGVAVVIVAQFLNYLLARVLLRWEKERRKVTDIKLQKITQYVEAIRHLRWYGWHFAWLDGVMTARQKELNLRIITFLLNTTIKTLNSFANGILPVATFYAYTVIAGRQLRIDIAFPALQLFSLLQTNIRELPNLITVLLNASVAVGRISDFIAEPDKADEAESNQSPSEHDRLELENASFSWPGLSATVLCNLNLSFPRGLTIVFGEVAAGKTALLHALLGELDLREGRLYKPQAAIGYCAQTPWLQSMSIRENILFNSPYEESRYKKTLEACALLPDLANFKHGDLSETGENGIGLSGGQKARVALARAVYSRTEVLLLDDPLSALDQQTAEWIVTKCLCGSLMENRIVVLVTHRTDLCQHLASQLIELSNGTAVLHRSDADLSKVTSATAVDDELVADNSKDIDESAAVPDRFVEDEYRAHGGVQLQVYWQYIKAGTIRWWLMVVLIAAVCRAAHVAENWFLKEWGEAYNKGKAQVLTLQILEADIHPLQSPISGLFDMFPDPAINVRPWLLGFLVIVAWETVGLVASQISMLVVTYSAARRMFQVIMERISNATFAFYDVTPVGRLMNRLTSDIGTIDGGIAELFMVVIWYAVAWVSSMIVIASITPTFLLFAIGLTLAFVMIFLRFLPTSQSLRRLEMVSLTPLMSNFGALLNGLMTVRAFNAQTQFQEKNIQVTDAFQKMDHFYWSLQAWLMYRFDTLSAVSTFLLTLLAIFSNLSAGLTAFVLISANKFVEATHAICKSYGQLQLNFVSVERVIELTHVEQEPASSIEPPAAWPKYGSDVVFENVTIRYQPHLEPAIKDVSVRFEGGSTNTITGRTGSGKSTLALALLATVIPESGRISIDGIDIAKVNKQVLRSRITFLAQEPILFPGSLRHNLDPMVEHSDLACESVLSRVCGKYGWTLETQIDDGGRNLSQGQRQLVGLARAILRRSAIVIMDEATASIDLETSAEIQRVLREELKESTIITIAHRAAAMENADFCVSLAAGRVLHQGKPGELGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG60</accession>
    <name>A0A1C1CG60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_03294</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG60"/>
    <dbReference type="STRING" id="86049.A0A1C1CG60"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03294"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01894"/>
    <dbReference type="eggNOG" id="ENOG502QTAT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="703"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="742"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="782"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="868"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="66"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="508"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT47489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="930" mass="104105" checksum="F56E631D0B21BBC3" modified="2016-11-02" version="1">MTSTFDLSMIPSSPGTPDSAGELRPTSASSARARPLSSRNNPNRRTMLYPQGDFRNSSMPDLRELKTDMMCNWLHQQQIERMWTTNSIEEGVFLKKAKDHYKCAPEDLSSRPDGVYDAVRRLNVKCAMTVNTGVVKLFLQDETLTHMPLDSGLRLQILPTINALPDCQKHQFAAFVRTNNILVVWDDDPNHILKRVQSIEDQLISMIWKEEFDDDASTPPALSAVPSTLNLSPNGNEASSQDHERPLAPRRIVLVQPILTAFTLILLIAAIGSGWREIAIELKVDHNWTRLAFIAVVPFQCWLALFFMQSVAGCCAQIIGPISQMNANTKFYSGMPPPRLPTDGSCVLPHVTIQCPVYKEGLWSVIDPTIKSIKDAISTYEMQGGTANIFINDDGMQIISAEEAQERRDYYDEHNIGWVARPKHNPKPNGEGEQAFVRAGKFKKASNMNYALNVSARVEDKLSANIQPTDGTWTVDQERTTYRAALAEIIHEDEGRTQAAGNIRVGDYILLIDSDTRVPQDCFLSAVSEMEASPEVAIIQFASGVMNVTDSWFEKGITFFTNLVYTAIRYAVSNGDVAPFVGHNAFLRWTAVQDVAYVYADINDGVVKEKYWSEATVSEDFDMALRLQTQGYILRLAAYAGQGFKEGVSLTVYDELARWEKYAYGCSELIFHPFREWVTKGPFTPLFRNFVRSNMPLPSKITIMAYIGTYYAIGSAWILTLLNYCIVGWFNGHLDHYYIDSFKIYFAIIIVFTALGNLALAIMRYRVEEKTLGSALWENLRWIPLLTVFLGGISLHVSQAILSHLFSIDMSWGATSKEATDTSFFAEVPTILRKFRFTFIFCLVVSVGMVIVAGVGPLGQMVPYDWQIGWFTAIWPLATVVGESLLISLPGVSSSCSSCVYTSRGNYTSRGGVRSVCDRKGVKPMIQRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH58</accession>
    <name>A0A1C1CH58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH58"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03574"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04498"/>
    <dbReference type="eggNOG" id="ENOG502QRU5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="378" mass="43515" checksum="EEC6C78E63C970A0" modified="2016-11-02" version="1">MILLRRTSVLSLALGALTLIYLLTHLHPFSSERPYLYGENDASALYDPRFFTPGTAEPAGANYTRVLVMGRLSKEDVSWLDDDLPDLPKKIYTVDAPDRSGLPANKGHEAMVYLTYIIDHYDALPDVVLFFHPHKITWHNNVLLDVSSATTIKLLSDAHVVRQGYFNTRCHLDPGCPDWLHVDQSRWKYDLHHKPEEPALTSRLFHDLFGDDIPIPDSLSQPCCAQFAVSGQRIRQRVRADYVHYRDWLLHTPLDDKTSGRVMEYSWQYLFSGRFTFCPSQHKCYCDGYGICFEGGDEGLKAWLNLLRQKELLDQKLVKLWDKGEASRGSEQYTKLRHQSAEMGKQLDDLRELAVRRGYDPQTRARECGREWHVGDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH94</accession>
    <name>A0A1C1CH94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Variant surface antigen E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH94"/>
    <dbReference type="STRING" id="86049.A0A1C1CH94"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03351"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04469"/>
    <dbReference type="eggNOG" id="ENOG502S41E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23954">
        <property type="entry name" value="AMO1_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099">
        <property type="entry name" value="RAD201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099:SF2">
        <property type="entry name" value="SI:CH211-113E8.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="676" mass="69715" checksum="6EDA413533ADD75B" modified="2016-11-02" version="1">MAKWTDPCPCTGRRDTWQFNPDDIPNDLAAGKGRPKWILSSYGPGKNAPASLLQDNEFSAEEVRARFYELAAQGKQDEADREAIALWTKAEQDINQIVNNARDVEKFIQEAAKTHPNRDDFTHMDGTKSKEQIIKETESSSSSNMSRGFGSNTGGGFGSNSTSSPFGSKTPAFGQPSQPSSGFGASPFGKPAFGQSGFGGASPAGGAFGASSSSGAFGASSSSGAFGASGGGFGSGSGTSAGAFGKPAFGQSGFGTSSFGQPAQPSSSFGKPSSPASGFGTPSQPQSAFGQPSQPASAFGQPAFGASGFGSSGPKNPFAPASASGGFGSTTSTFGQPSQSSSAFGQPSQPTSAFGQPSQASSAFGQPPQQSSAFGQPSQPSSAFGQPSQPSSAFGKPSQPSSAFGQPSQPSSAFGQPSQPSSAFGQPNQPTSAFGQPSQPSSAFGQPNQPTSAFGQPSQPTSAFGQAQAQAQPTPSGFGSSTAPAFGQPSPPTNPFGAKLTGDQPKDENMDTTTPASSQPQPRPHPFGVAAPHPLPPPPTASALPASTSTTAHPLINKPARALHFTESLPPGPTQKNQAGRLQTYRGQPVAYENNVPCYRRPDNRESEKIWFPDGAATPDVVALNREDKIWDLQGDVAEYTEDVLESFRHLFSEGRWKDGKMPLVPPLREWVVYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHA9</accession>
    <name>A0A1C1CHA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11271"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04506"/>
    <dbReference type="OrthoDB" id="4156953at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="49739" checksum="0B0911B5BBD8A0DA" modified="2016-11-02" version="1">MGTNMIYARLQVVETVADRATTPLVSGSGDSSGPYSAPFRINGRLSVLDDSIIRHAFDTVQLCLRGIITSSIGYRRVLEDVITLTDIKTPLQFKPTSAASPDDSQRGRHVDFYFELPTSTSASDGTYRPIPLSGTFKGAVNLNQNHPLNQNCVIPGECEVSYWIEAHFRRAGEQVGFLHRHVQIRSLYPRLRASLTRATPLTIRAKPDIFTRCRLQKCPDLSLTLSDSGMVVERDPATGKRRITLPLAVAMNASDASPVHSRQSMTCAAEVKWLVTTRFSTQTGCKGPKRLSPGEVVRKTSMASTQKSTILFRPLPQYDNGEVNSVKHSPPTPFIATSQLDLSVPDAVCQPSLDWMYLARTYTLQLSLQFRGVQGAPNYSVNVSLPLTVSAYGSKADDALAGEAFLDDSETDEEDALLEMLGPLGLGQPEGQTPLQTRPQRAITRTPPPPYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHC4</accession>
    <name>A0A1C1CHC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_03253</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHC4"/>
    <dbReference type="STRING" id="86049.A0A1C1CHC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03253"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04482"/>
    <dbReference type="eggNOG" id="KOG0051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="791"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="941"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="941"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="985"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="631"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1066"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1085"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1099"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1166"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1236"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1274"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1289"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1306"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1339"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1401"/>
            <end position="1411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1456" mass="161332" checksum="FF1F24FAD2DCFAEB" modified="2016-11-02" version="1">MGNTQSHEGDSAELATQAGTEDCEYALSVAEDRMVIELTAPSVEFDLSQIPDDRDVSEQNPPAHVQTDQQLSDASTNALRRIDSSRPQEPARRKRQTVDRQAGRRKRERKRRRSSNNTSNEAAGDILVRESQPAPESLDPTEEDRPLKETEPETYHIYATSDESDAEDGDHRMTWRVPNGFKAVNGSSHHGLPKVQDESAADGGSDEEHAAQASGHATDPDSAVEALNLLASVAGTQPSAAGPATKAAMKISRPRQTSEGRYTCPWFDTYGCTQTFAQMKGAIRHAKLPHTTTTVEAVVRTPTTTQTTTAAQTQTDQSADAPQNAEIPPPKVTSEGRYMCPWVNVYGCDMTFAQRKGAMRHANLHTKQFTCFVCNKAMARQDTLLKHMKQHNGMEIVTATHADAETTQKGDTPGQQSNELPEEVGAEAEEPQQDVSDDVSGEFATPEVASRPDEDTKRSSFESVPRGVQDVGDTVIQGTEINGDAAREVSNRPSTEPSSIFDEEDTIAKQTPIAAGELKRKRSVEGSEGVSRQSLERNRKRKKASWGTPPTSIPSVEPVRPETPKSSAVEAAARSRQITDKIVPRLQTRQGSMDDWAQKFTPGSNLRHPTLNPTPPRPITQQIEVLIPHTSQAGPSGLKQRRIRAPPSDEATAVSDEDAEADTFTKFRRKKLRKATYATPKGKKRAQPDVEYSTPAKEATIMEGEESEADKSDNDGMSPVDIATSVAKRTFPGRQQAPTADNDQDSDFDLTRAPESDNESTQAERPAAPAKKLRKSTGTKKTERPSSADAVECVRCHRVFASQDQLRKHQKKRSAHVGLVKCHDCSEEFYATAGLIRHEKDTGHGRGNGLQGRVGAFSQDEVNTLNKWRDTFCDYHNISRTEFNDMMTSTLERGRGATWNWAFVKRAEFLKEYLNVLPNRNKRSMLRYRERNFQNVEGMKNWSAEDDKELIRLQKELGTKWVEIARRLGRNADAVSQRWRHKLQYGEVETGEWSQAERAKFGEILEEFCTDKDGNEVEHMQIPWNKVSEKMGSRSAQQCSNHYRTLHSKKERGRWVRVNALEKAPGSSRLLKTSKMALRLSGQTRGERTPKKGLSEEFIREDDEGDDESDPAEEDPEDEHTQKDSPNAQRPGSDVEDEEEDDPRSGPEDTTSPAPVTRKRKPLPTKTPSKPMRSSQLFEQTQTNTSALKPSQTSSRRSGQPSQDRQSPNIPIQRRHISSRTPLKEPHTSDNGQLDGDVEDDSDDGDEDARGKRESSQELSTVSDTDADEDGNENENKAQGDEEVHDESPPEDSADEPENEMGRAESEEETPDEDDEASDDEQAVSYESGGEEVAKNDGDAGDLVDNGAEEEDTDDSIDTDEATQDSNESDAESASEDESVPESGEEDDAQEDVPAAEAEPPTSSFMASINESAKRANIKKVRSGSQNHGQTMLGFPTPGRHSRRDIWQRESDEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHE9</accession>
    <name>A0A1C1CHE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_04201</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 10">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHE9"/>
    <dbReference type="STRING" id="86049.A0A1C1CHE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04201"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08108"/>
    <dbReference type="eggNOG" id="KOG3954">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="12">
        <location>
            <begin position="37"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="278"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="295"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT47940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="350" mass="36494" checksum="AC2115551720ED82" modified="2016-11-02" version="1">MLPIARQSALRAVRAQTAPRPLLTPAQSSFLARLLSTLAILEQKDGKLNTGSLGAVTAGGKLGGAVHGFVAGKAAKTIAQEAAKIKGLEKVIAVENEAYERGLPENWAPLLVENIKKGGYTHVIASHSAFGKGLLPRVAALLDVQQISDVMSIESEDTFVRPIYAGNAILTVQSTDSTKLLTVRQTSFAPAETEGGSAAVEDGVDPKVESPTEWVSESLAKSDRPELASAEKVVSGGRGLKSKEEFDRLIPPLADALGAAIGASRAAVDSGFADNSLQVGQTGKNVAPQLYLAAGISGAIQHLAGMKDSKVIACINKDPDAPIFQVADVGLVGDLFEKVPELTEKLKSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHT1</accession>
    <name>A0A1C1CHT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_03977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHT1"/>
    <dbReference type="STRING" id="86049.A0A1C1CHT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03977"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08229"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF43">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650823" description="3-phytase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT48070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="580" mass="63489" checksum="BB99791C1A5C4E7D" modified="2016-11-02" version="1">MVSSKLLVLSCGLAGAAVLDPRQATTASGETTASATEPWYYQTTPELFAGPTTTGLIAPFLAQTNPAPWGAGASYVPNAPLETNVPIQGNTNNQSIFQLHGQLSSYFPNPLGFGSNEYPLPPGANISTVHVLHRHGSRYPTGTSSVASFGSKIQNITANGTAKWTGDLSFLNSWKYNLGAEILVARGRQELFDAGVLFYYDYGALYNTSTKIIARTTTQDRMLKSAEYFMAGFFGLEWTQNASLVPIIEQNLFNITLAGYMNCNNSNNYLSTGGNNASVIWENIYLANATKRLQALAGGYNWTVADSYNAQTLCPYEHVAFGYSQWCDLFTYEEWQGFEYSIDLQFNGNNGFGSPTGRAVGIGYVEELYARLQGHLPDVPPGTTQINTTMVASTATFPLNQTLYFDFSHDTNIMSIITAFGLKQFAQPLGPTGPPANQQLIVSHTTPFGARMASVWEIIHTPQPLKAIRPTSSNATASDYYTNGTATTYIHLTISQRTVPLYKSYPQCEERDDGWCELSTILQIWGGLLDQAEYDYSCNGKYPAVAPGNITNGVPISKRSLGRRFGSSLEFYESSDRWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIJ7</accession>
    <name>A0A1C1CIJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIJ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CIJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04339"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08472"/>
    <dbReference type="eggNOG" id="ENOG502S263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="498286at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="25282" checksum="349283B797E9CCE2" modified="2016-11-02" version="1">MAVPPDSENTPSPFALTAVDRAVLAMTDEEFRPHTWDELKQIIAEHNLSVLKRWPSDLRRYMKWSAETKAAYGSVPNFVMKERLKWDPLPSSQRGPDFEVRNPVPFADPADYKILVNDWPYGLEPGIKHIIVWLKGRLESEPTRGDMTPKSRQQVEDFIQSKFIDRVKDLPGEQEKVIWFKNWTALQSVPGMEHVHVLVRDVPEEIIREWTGGDQPING</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIQ7</accession>
    <name>A0A1C1CIQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Superoxide dismutase 1 copper chaperone</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Superoxide dismutase copper chaperone</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CCS1</name>
        <name evidence="11" type="ORF">CLCR_04291</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCS1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIQ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CIQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04291"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08535"/>
    <dbReference type="eggNOG" id="KOG4656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000009">
        <property type="entry name" value="Superoxide dismutase 1 copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000038">
        <property type="entry name" value="Superoxide dismutase 1 copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="10">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT48405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="248" mass="26187" checksum="CFDFA481C4981765" modified="2016-11-02" version="1">MGSVGIEPFQTTFAVPLHCESCVDDVKGALQKVEGVAKIEANLKDQLFYIEGTAAPSSIVSAIESTGRDAILRGSGTSNSASVCILETHAKGVSDPVRGLARMVQVGGNRTLVDLTLRGVSPGTYHATIRETGDISRGAASTGGIWEAVKQMTGIGQPRGMFGTVQVGKDGRGSAFLDRPVSVWEIIGRSMVVSKQQQEGSFQTDDPDTLVGVIARSAGVWDNEKTVCSCSGKTVWQERKEQVGKGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIT3</accession>
    <name>A0A1C1CIT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gstA</name>
        <name evidence="5" type="ORF">CLCR_04312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIT3"/>
    <dbReference type="STRING" id="86049.A0A1C1CIT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04312"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08491"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000172">
        <property type="entry name" value="Glutathione S-transferase GstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="25"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="118"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT48351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="273" mass="31634" checksum="519F7454B233613C" modified="2016-11-02" version="1">MSHRLQQQAQHVSTQTRSNMADVKRPNITLYTDATPNGLKASIALEELGIPYKFEHINISTNRQKEPWFLEINPNGRIPAMTDTFSDGKQIRLFESGGIFQYLVDEYDKDYKISFPKGTREYYEMTNWVFFQNAGLGPMQGQAHHFVRYAPEKIEYGMNRYVNETRRLYGVLDKHLQSSKSGFIVGDHVSIADITTIGWVIWAAWAGIDIEEFPTLKKWEEMMSAREGVKRGCNVPKKVDIKERMKDKKALEEYAKHSSQWIQQGMKEDAQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIZ7</accession>
    <name>A0A1C1CIZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">amdS</name>
        <name evidence="8" type="ORF">CLCR_03981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIZ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CIZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03981"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08628"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF5">
        <property type="entry name" value="GENERAL AMIDASE-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="82"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="235"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="515" mass="56626" checksum="DC21A54BFA5B4E5E" modified="2016-11-02" version="1">MVREDWRTLVAAKRAQVAKALPQEWRLPSSILDTVSPTADTNILDVPAKCGLLTEKEIDITEKHDATDLIAKMAAKELSSFEVTQAFCKRAAIAHQVTNCLTEMFFDKALERAKYLDEYLEKEGKPMGPLHGMPISIKDSFNLKGTYSTIGYVSFISRPAAESNSALVDILLANGAVLYVKTNIPQTLMTADSENNVFGRVLNPNKLRLTAGGSSGGEGALVAMRGSLLGVGTDIGGSIRIPAFCCGTFGFKPSVDRVPFGGQTNPVLDGWTGIMPVAGPLAQSPRDLRLFLETVINSKPWNYDYTALAMPWHPVEEKTTLTIGVILECPTWPVQPTILRALKTATDKLKQAGHNIVMLEKFPSFAAATQLSWNFFDIDNEGTGFKHIEASGEPWVTSVKDMYTPPPEGRKVKSLGELFDMNEERLKFRKDWLKIFVENKLDVIVAPGSHKTAVPHDTFRMPPYTTSTSLIREFQTLVDDPEAVDGAPCHVQVIARSEQDEELMAAVELISKVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ82</accession>
    <name>A0A1C1CJ82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Complex III subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_04318</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ82"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ82"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04318"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10272"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000003">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="12">
        <location>
            <begin position="95"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT48575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="164" mass="18258" checksum="F1A3F981AA735CC7" modified="2016-11-02" version="1">MGITDFFSDLLSSVSFVQDVQAEAPADDKEDSGEEGGDDKDKKEEDGEGAAEGDDGEGGGDGDEADEGEEKEGGEDDDEEEEEEEEEEEEEEPVDPKPRLEEECARSAQCQGYKHHFDECVERVTKQEEDPDYKGPKENCVEEFFHLQHCATQCAAPKLFKQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJL9</accession>
    <name>A0A1C1CJL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative HC-toxin efflux carrier TOXA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TOXA</name>
        <name evidence="8" type="ORF">CLCR_04679</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04679"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03235"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="74"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="594"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="619" mass="65640" checksum="A61EDB0D164B869E" modified="2016-11-02" version="1">MLETFRDVDARSAMPSTSSVDVVQRDPTASPLASDIATSMSATTVSKEKQESTTGGQGHIDASTSTSNLQFVSIVLALCLAIFLVALDNLIISTAIPTITNTFHSLDDVSWYGSSYLFTTCSFQLVFGKAYTFVSPKYVFIFAIFLFELGSAVCGAAPSSVALILGRTIAGVGSAGVFSGALIITAGLVPLEKRAIYNAVLNSMYGVASIIGPLIGGVLTDNLSWRYGFHSAPCVPVSEQASSTDCRVSSWCFYINLPLGGVSVLVLLFALRSKHTSKNSRTATLTFKQKVAYLDILGTSILIPAIICLLLALQWGGTAYSWSNFRIPLLFALSFTLGVLFIVVQFRQPGPNATLPPHILKQRTMAAASFFTVALAGPFFIFIHSVPIWFQAVRSTSAVRSGVLIIPLCLGVIVMSLASGVGTAQLGYYAPFFYISAVLQSVGAGLMTTWTVATSTATQVGYQLVYGCGVGFAMNLPFVCASTVLAEGDVAIGTALITFLQTLSGAVFLAVSQNVYLNRLASSLSRDLPGLDPNLVLRVGATELKNAVSPGDLDVVKHAYNDALTFMWYISVALACVTLFGAMGIEWRSVKAKKVGEGREADEEGIKPGGEGVKSSEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJV8</accession>
    <name>A0A1C1CJV8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CLCR_04521</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04521"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03104"/>
    <dbReference type="eggNOG" id="KOG2088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF7">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="824"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="440"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT48804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1169" mass="126305" checksum="49778C5B93B75CF0" modified="2016-11-02" version="1">MLWSSNKGSASTSEDEKTVGDAGDDVPEEIVLAQPQQGRTLLPAPAAAIVSGVTGLTSFYVRGATKVGGWGLYAGREATLKTLSVSRSALESILIAAGRDVSARSNGELGRAEAENLLERSISALHSTISTTSFVASTGFYLTEAFMNSISGLSIQGLATLNAILGSTESSRAVAAIITLIRDELNKPEVGGSGEVVTYLDLIIGTIGFVLLQRWGRRKTELDFRDAGGEETIWDAVIDDKGFRADVVGTRRKGMISLNTNVGGPAMTFASPDDEDEIEALERGTLYDAQTVALSAEDHTKLSDEEIRERIMSQVPTGARAVITSETITAKTIKVDIYDGHTAHIDPPPGTVMVAERLNHESSGNGMQGVPHQTVIFRTSLKRSSSAEMPSSSANQLRLTVSHGSPPDHLDVEDMLEMRSAPKRISIVDEPVQIEPAMFSGSERDDEAIESSSPPTSSPPKPNGPVANQKKSRRPVLPSSKSPPATSATSRIPLMKGKKDKTSMAAKPDKGGVLKKALKTLSPSQSSAAVKDIQRAPSKPQKQLPSVPVQASRSRAPSSTRGDSTPHRAFASLGHTPLTSPSLHRAAESSTSYFAVQHRRRDSIVSQTTETFSVHSHDSRPGSPTFTRTRTRVVNGLTPTRSELGMALDETESRLDPTTGTVHHRRSRSFVPSLYSMATKDSKEAILLAPKTPLPRKSIYEDHSILASLINDGKVPGIFPDRHLVKTVRRFARFASASYGSNFLRIMGLTTSEDDLSKSTELMTLNVHHEHSSFSSHTGLPPDTILLSSFYDPKGVTGNTDWSPSAISPLIHFISIDDDSKAVVLTCRGTLGFEDVLTDMTCDYDDLLWQGQRYKVHKGIHASARRLLGGSGSRIIATIRATLEQYPDYGLVLCGHSLGGAVAAILAILIAEPSSDDSKTSFITGNKPKLLTHQPVNGPYTSYIPPITLPAGRPIHVYAYGTPACMSELLRSATCGLITTIVNHADIVPCLSLGILHDFRTVALHLKHDTSDALGALKTRVWNRVTNAVKSAFYNNPKGPPPPENMAGDGLGEDTWAWAALKTLRAAMINDKLVPPGEIFVVETTRVFDRLDPDVAREAVFGPDDSRDDRTEKLYRALGRPATRVRMTWVRDVEKRFGELRFGRDMFGDHSPGRYEAALAALEKGICED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKV2</accession>
    <name>A0A1C1CKV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_04732</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKV2"/>
    <dbReference type="STRING" id="86049.A0A1C1CKV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04732"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02791"/>
    <dbReference type="eggNOG" id="KOG4323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15502">
        <property type="entry name" value="PHD_Phf1p_Phf2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="347"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT49134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="588" mass="63121" checksum="1BD4082AEC8119B5" modified="2016-11-02" version="1">MAAPPTDPTGSSETNGYWGHIDELRQHTHDTFIMHPAVPPLSFQAMCHGTNDRAELTTSDQTNNLSSQAPFKPSADTGLGPRRASSPDVLPQGHAPPPSIKDSNPNLRGGMPDFPKGAKPGPEDAPTDSDHDFRYSTPSAKVDQAPRSVSTAEHADTATIMVTGQVHTPGATESATIAATKRSGSRRNKQYTLPNGSVVTGKGLGRGRPGIKRGPRKSQVGDQPSPQVMSVDSADASSHGRGPASKERKSPGSDFSLRWASSPEPAALDSEESSEEYNPTLHTRSGRQTQKPTPLTKTIAASASASASPSGKASRNTPNVNGSSTSTPSIKTHPKIKRRIYRGREQFALCEHCLRGHGPPGNVIVFCDACNKCWHQRCHEPQISKQTVADSKAEWYCSECDRILHGKKKEKKPNGKLSAQPVVVALPAVQQAPPYAGPLVGGRFLPPEQKLAYLKTLSKEDLVLRLLHASDLAPDLPLFQTLVPPAPPPVVMPQAQFTSTYVTPVSKVPSFRNRDGGQGDEVDEGYDGYYDEHAALYPKPGHGLQLLPESEDLHMLLEGKESKTFSHWQRSTPGPLFSGSGNIISAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLL4</accession>
    <name>A0A1C1CLL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">CFEM-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CLCR_04747</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLL4"/>
    <dbReference type="STRING" id="86049.A0A1C1CLL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04747"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03311"/>
    <dbReference type="eggNOG" id="ENOG502T2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650937" evidence="15">
        <location>
            <begin position="22"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="16">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="17">
        <location>
            <begin position="125"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT49394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="419" mass="46312" checksum="9DFC1F5621C2AEDB" modified="2016-11-02" version="1">MALKGFIAILTIVLWGQLASSETLTLSDCAANCTSDITSRFSACKFGIQCFCTDPPLFDLGKQCWESNCTVREALTAENVTSISCNFPDRDRGPASSAVTFTSMAVALCLVATRIIAMSPDFRVLWGWDDVLVGLATLLMIGNAVCNPISRHYGYGRDTWRLPFDDTKTVEMIFYIGGVLYAVGIASTKVAFLVFYIKLFSSRIFRWVAFPLLVATVLHGLTFTFLFIFQCSPVSYAWTRWDGTGQGKCLNFDLGAVMHAITNILLDLLIFALPIWQLWSLSLSKRKKFQVISMFCVGFFPGVSEACERWLTVRAGDFVPFGYWSDLEFNVGIACICMPSLRVVLRRYFPSCGLTSTHRDGSVSGPDMAAARPVPVALTQSSIAKMNVKSFRSSTRPVKGDNASDQVELCEYNTSGELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMG5</accession>
    <name>A0A1C1CMG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fabG</name>
        <name evidence="4" type="ORF">CLCR_07255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMG5"/>
    <dbReference type="STRING" id="86049.A0A1C1CMG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07255"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09929"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4131217at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="318" mass="34090" checksum="92332513A6FAE04B" modified="2016-11-02" version="1">MSTVTTPKRRLEQLTGQIAQPPIIDEGTYKGMPRVARRAGDSAAQRAIGKVVIITGCNSPLGMGRATAHQFARNGARAVYICDYVDDHLHLHVEELNELYPNVDVHARTFHAGDEAGVKAVVAHAMQTYGRLDVFFANAANSGTWKEVWEMEVDEFERTIRTNLTSVFLAIKHAGPAMQVTSKDKPYSSGSIIATSSTAGLRSNGGSTDYSAAKAGVVSLVQTACYQYAGRNIRCNAIAPGMTHSGMTEPVFYGPARERGTLHKVGQLCPLRRGAVADEIARVALFLGSDEASYVNGQVWAVDGGLSSGLPYKLGSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CML7</accession>
    <name>A0A1C1CML7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-I complex subunit VPS28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">VPS28</name>
        <name evidence="9" type="ORF">CLCR_07535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CML7"/>
    <dbReference type="STRING" id="86049.A0A1C1CML7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07535"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08657"/>
    <dbReference type="eggNOG" id="KOG3284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.200:FF:000003">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="32"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="162"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT49733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="256" mass="28433" checksum="36BCA4FFB80A52F7" modified="2016-11-02" version="1">MYTTTSPRPPSNYNPVQAYAPTPYGAFPSSHPLSARISLDEEVKLSSTPAERDLIDSLAEIYSIIRTLDGLEKAYIKDALPESEYADLCNKLLKQYRSILQDESVAREFGDLDAFCERWEVECPRAKERLRVGLNTVDTITVSQQSASGPGAGGAPAPKANLSGALILTATENFITFLDALRLNMVSKTSLHPLLSDVIQSVNKVTDQDFEHRGKIIQWLITLNQMKTSEELSEEQARDLAFDMEQAYNGFKAIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMN7</accession>
    <name>A0A1C1CMN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07212"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09955"/>
    <dbReference type="OrthoDB" id="4396256at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38078" checksum="A94C226DAB40DE91" modified="2016-11-02" version="1">MAPTDISRPTSFTDLPDDCILILIEELAEFHNWYHPLPQDVKNLSLVSKRLRHLCEPALFKDYYGHVVMPRIGDRADAGILSGLSGSTFFSSRLHAFEITLLQNDHPGFYNSFVMAIKAMTDLFQLKVNLCNNAVVASHLQTELERTETILPTVGVLHLTTAPDSVALLLACPHLTTLVAEDLTLGWKSALRAIPTLQCLRHLEVRKNLTNWTARSIQVLSITSTQWHKQTSATESCDDMDPEERWAYMLRKDDKRHTTEDPAEVAQRFFAICPRLMVLRVLQRRWSEKYLCKRETDGKVQAIHHVESGDNWAGYPSSFSSTPWTIGHGMDGLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMX1</accession>
    <name>A0A1C1CMX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_06612</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMX1"/>
    <dbReference type="STRING" id="86049.A0A1C1CMX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06612"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08724"/>
    <dbReference type="eggNOG" id="KOG0500">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000057">
        <property type="entry name" value="Cyclic nucleotide-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF24">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G03170)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16643">
        <property type="entry name" value="cNMPbd_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="66"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="266"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="564"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="195"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="440"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT49801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="964" mass="106162" checksum="C01950CE82AF540C" modified="2016-11-02" version="1">MRRHHGRALSPYHGRTASPPSAEVSLVRSFDSKINPSRPARQSPLATSQIGGMPLDLIDRIRSFPLFQSTSDDFLADIGLLLKPQLYNTNDYIMIEGEDAKAMYWLVRGAVAVTSRDGESIFAELKPGAFFGEIGILMERPRTATVVARTRCMVVVLKKEDLKKILPKYPDVEQAIREEALERLTQLEKKKAQVLLGTEDVPDHERRGSKRARPTLGDDAYMAGSDGSANSKRRKSPSPGTNEVSTASALGHGLVNIRATLKELPLFASLPPDILHFLGLSAQPRSFAPFTDIVKQDRRGREIYFIVRGEVEVLDERKVSHPKLHKSGQPNGIPRTPVVKARLKPGQYFGEVVSRGLADRRTATVRSVTQVECLMISENVLADFWNRCPPSILQQIEETAKHRLKLSFEADVVMKDADATPDIRELEIEDGKERRTRKLVNGPRVTFTDAGAEISSSAPSVQKEEPSTLEPSDPDPFLSEGLEKVRSRSRRGSLAPPPPDEPSKDQKRRSPRSSPTNTASPSPKASVSGTPSPTSEYKGLTGFPFSDPFSSGGRPKPRARSSRGLNRGTVPEKVLPLILAYLDLHELMRLQGVSLHWQNVVNSAPNLLHHLDLSRYNRRVTDDVLINRICPFVGQRPRFIDISNCFHITDEGFAALVNTCAATVQGWRMKSVWDVTAPAILEMATRARGLQEVDLSNCRKVSDTLLARIVGWVVTAHPQAPSNRTKTHAQRPVVNTKLGNNAAQPPPQPAPGTVIGCPDLRSITLSYCKHITDRTMAHIATHAHTRIEAMDLTRCTTITDAGFQFWGNVKFERLKKLCLADCTYLSDQSIVWLVNGAGSGLRQLDLSFCCALSDTATEVLALGCPNLTHLNLSFCGSAVSDPSLRSIGLHLTSLRELAVRGCVRVTGLGVQSVVEGCQKLKLFDVSQCKNLQPWLVSGGIERWRSLGRDVEFVVVSSGSKVVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN68</accession>
    <name>A0A1C1CN68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07719"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08808"/>
    <dbReference type="OrthoDB" id="4130649at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="40"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="151" mass="17092" checksum="6CD62142C7392DE8" modified="2016-11-02" version="1">METANQDDKHQAETTSWGVPKHLFDYTEVVTFHTGTGPQRQYFAMHSPRLCQESTYFHERLHGDYAEARSRHFEFKDHDPAVVACMVSWYRGWHCPFCGHHSGHVKDAMLLARELGIPRFSNHLVGMMEALNGDGLSRSDAMPVTATGTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNG3</accession>
    <name>A0A1C1CNG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fuy1</name>
        <name evidence="10" type="ORF">CLCR_07023</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNG3"/>
    <dbReference type="STRING" id="86049.A0A1C1CNG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07023"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08971"/>
    <dbReference type="eggNOG" id="KOG2638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT50054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="524" mass="58751" checksum="87B1399FF28A569B" modified="2016-11-02" version="1">MPHLEAPPPIDLRQPTLSIKRSTHHPDLTLIKSPAMQAFENTSTNVAASQMRNALNNIADTVKDPAEKKRFEAEMDNFFALFRRYLNDRAKGNTIDWAKINPPNPDQVVAYDDLPNTDAVEFLNKLAVVKLNGGLGTSMGCVGPKSVIEVRDGMSFLDLSVRQIEYLNRTYDVNVPFVLMNSFNTDEDTASIIKKYEGHNIDILTFNQSRYPRVIKDSLLPAPKSYDSQLSDWYPPGHGDVFESLYNSGLLDQLLERGIEIIFLSNADNLGAVVDLRILQHMVESRAEYIMELTDKTKADVKGGTIIDYEGRARLLEIAQVPKQYVNEFKSIKKFKYFNTNNIWMNLRAIKRVVENNELEMEIIPNEKSIPADKKGEADISIIQLETAVGAAIKHFKNSHGVNVPRRRFLPVKTCSDLMLVKSNLYTLSHGQLVIDPNRFGPAPLIKLGSDFKKVAQFQKRISSIPNIVELDHLTVTGDVNFGRGIVLKGTVIIVATENSTIDIPPGSILENVVVQGSLRLLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP09</accession>
    <name>A0A1C1CP09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_06746</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP09"/>
    <dbReference type="STRING" id="86049.A0A1C1CP09"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06746"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05771"/>
    <dbReference type="eggNOG" id="KOG0490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN INVECTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="67"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="3">
        <location>
            <begin position="69"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT50212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="707" mass="77444" checksum="B16BC521CD658212" modified="2016-11-02" version="1">MNMAYMQQNAFAFAPQPQPQFFYHPDQYHTYVAHPQQAPDEFYMPYAGAEYADFMETGMMHDDMGESQEISTRPRLTKEQAEVLEAHFQANHKPSSQLKRELAIQTGLTLNRVGNWFQNRRAKAKQQKRQEEYEAQTSSLNVQSNEPEGDEEAEDVKDAKSSEDSRSDAVSPTGSASPTKASSTTTTTDSTSAVQTPDTPVQAVDNSKEASWNSLQRALGQAKAARAHQSGQAQVSMSPPKIPARAPGMQLPLRLNHHQTTPSTSYVSAWRSQHANYMAYPSPITLQDTSFDFGFGNDIVDQAPAQESTIDPVVDYAQDSFVVTPQDFQEPLATPKGITHQQNDPMTALPSPGFSMPSYPGSRRPSATEDLSATFGNVALAGTPPNFVPELYGAASICPPPSGPLDIAARRKRPRPAALTSASLRSRSYGAMTSVSPTFRQGIMSPQGPHSVRHVKSAGQSLHSRYAGIRKASSAQRSPMCATTFAEADAFNQLMAQQAIATAPLTEMPEPLLSPDHVSHDFSSVEPEKNPFFIQNMDMSNQYSMPPPQNLSITTASPPATPMIANFMSRGPSQQSLVPPASAPPQYATFPDYTPPYSAGPLTNSSWSDAPMTSPDVPSFPVTYISSVGFPQHYDAVDSQIQQYVLRSDNKSEVDFDSHFDQKKMEFCIQEFPNQKQEHAHVAQQLAQQKPKAYVFANTAPQDYNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR88</accession>
    <name>A0A1C1CR88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein transport protein yip1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yip1</name>
        <name evidence="8" type="ORF">CLCR_08844</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR88"/>
    <dbReference type="STRING" id="86049.A0A1C1CR88"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08844"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09658"/>
    <dbReference type="eggNOG" id="KOG3103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="316" mass="32950" checksum="7A19345315866DC0" modified="2016-11-02" version="1">MSYYNQPYGPGAGSGGGAGAANLQFYPSSYSNVSGHTTPSQASYGGYGGSGNAANAFSAYGTGSSGAFGAGPGLQGVSGRMGDSSGGLRMGWLAAFGTEGYEGEPGLMEELGVNFGHIKTKTLTVLNPWTRPSPHIMDDSDLYGGLLFLVLYGTFLALSGKFFYGYIYGIALFGSFALHWMFALMTPPIDPSDSDQMSQAQRDHHQGRDGHGGGHFSSTLTYSRSASVLGYCFLPLVFTALFGVAVPMDTAMGYVLTAMAVGWCTFSSSGMFVSVGRMKGMRGLVAYPLALFYLGFGIMGIFSSRGSGMLQGSVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRB3</accession>
    <name>A0A1C1CRB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA replication complex GINS protein psf2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">psf2</name>
        <name evidence="11" type="ORF">CLCR_09184</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRB3"/>
    <dbReference type="STRING" id="86049.A0A1C1CRB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09184"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09683"/>
    <dbReference type="eggNOG" id="KOG4071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="10">
        <location>
            <begin position="5"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT51047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="178" mass="20392" checksum="EF60AF82C051545F" modified="2016-11-02" version="1">MPPPWLLVESLQDILETETHKDFTESFSPPPSIPAQRQTDYSGRAFYTSPPFVESCTVNAVPTALPYHWFEVSEILLEAASDDIPESDKVRQLLRDIREVRLAKMRRQVERLSGDGEGTRLDGVGAMEVSESRGFMVGVVDGLRKLDASREQERREREEAERDNQRYNDEDDEDDDMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRQ9</accession>
    <name>A0A1C1CRQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRQ9"/>
    <dbReference type="STRING" id="86049.A0A1C1CRQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08679"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06897"/>
    <dbReference type="eggNOG" id="ENOG502S6PD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4838853at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="348" mass="39185" checksum="92D30A3B71B6A21D" modified="2016-11-02" version="1">MSMPQPGPASLENPQDEPRPLESDNPSDSDKTLEQRATGGPASAIEPPPANNPTLEKFTSLTHRDGRERLEGPPALPFNMRDHKLSVSIFTLLVVAECTVVPLVLYYGLKYGTTMRSGIYFAIITSLFGFVTGYEFGIRAWRLIRTSDEYRPLFGSPRFWGFDSTHYVLTIPFTVMLVIMIIFSIPHHPSVRALSLPMPVGMIVTGIMFVINGWAAQRGWRLMYFRLSSHVKNSICPPLTFCLLEDICAVDGKGGKKFRTAALARYQASPRFRALLLQLLWFWSIPAIVIGVVLIIVIYVTSDDVAYGVGWGMPTIWALVWTWITVEWVRRALQVEKECWKPETSQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSC2</accession>
    <name>A0A1C1CSC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IQ calmodulin-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_08266</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSC2"/>
    <dbReference type="STRING" id="86049.A0A1C1CSC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08266"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06693"/>
    <dbReference type="eggNOG" id="ENOG502QRIN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7344096at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044159">
        <property type="entry name" value="IQM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250:SF27">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="462"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT51390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="553" mass="61999" checksum="439CD2D6EAB0206D" modified="2016-11-02" version="1">MENDAISDHTKGASQPSTDLSAEEAKKAAVLIQKTYRGHRTRRQLNGFGLDASTRWYEAVRDARFKQVTTPRPPSPGGESGSPDAEGDRTTTPSSPARAKWTRATEIARRAGADDRSPSVSDLSSSDMSEEGQGLETVPTQQEKAATRKRRAEANAVRKKTAKMMDLQYFLEMVDQKHRYGSNLRKYHNYWKTQDTDQSYFYWLDHGDGRTVELPECSRARLDREQVRYLSREERLQYLVKVNSNGLLVWAKNGELVWTKDELFKDSVNGIVPIDDPSPQWKYNVPPAGGSGSSPGSSDDSDDEDDKTEGDEGQRVRGPSKVKHVSAGVLFNHMIRTSLKNGHKWIFVADTSFRLYIGYKQSGAFQHSSFLHGARILSAGLIKVKHGQLRRLSPLSGHYRPPAANFRAFVHSLRDAGADMSHVSISRSYAVLVGLETYTKARKQLKSAEDSVVHEKDKLLDPDKVRMEEEAQRDKSQSAETERLYLKKQREAEEREVRERKAKRSLTGRLSNAIGRLKFRGGSGDNAPVGEEQAKRIMGTGPEDGVPPPEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSU4</accession>
    <name>A0A1C1CSU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lsm8</name>
        <name evidence="10" type="synonym">LSM8</name>
        <name evidence="12" type="ORF">CLCR_09328</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSU4"/>
    <dbReference type="STRING" id="86049.A0A1C1CSU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09328"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06517"/>
    <dbReference type="eggNOG" id="KOG1784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422364at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000027">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT51579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="100" mass="10960" checksum="A2EE4D3095FABD15" modified="2016-11-02" version="1">MTLTDTWACAEKVLVITVDGRTLVGTLLSCDQVTNIVLNDTVERIIRPADDPEPSSQVSHGLYLVRGDNITIVGLVDEELDNSIDWEKVRGEVIGSTKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT41</accession>
    <name>A0A1C1CT41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT41"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08909"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06437"/>
    <dbReference type="eggNOG" id="ENOG502S12X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF84">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34205" checksum="745243667BEA79CC" modified="2016-11-02" version="1">MASSRPSPKKSPSFDLEAYWEHRFTASQTPFEWLTSIDVTASILQREIGDALSNGNGRFDESGPCILHIGCGTSGLSLRLRDYVRRPVDVHNVDFSQQAVELGQQREKECFGNGALSGAGIGDEVRGNQSDTNTSWMRWSNVDLLSLHGVLSLTDEGTTRYDFIIDKSTSDAIACGDDVDFLPTSIDHGGVQRVTRMHPVEVLAMHLAAVTVMGGRWIVISYSAERFWFLEDNTKRHTDLLSQGNTGQQSGRKVEPGDYWRLDRKEPIAASEAGNTLYGNVRRPQIHHWLYVLVRTMVPFQARLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT54</accession>
    <name>A0A1C1CT54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CLCR_09041</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT54"/>
    <dbReference type="STRING" id="86049.A0A1C1CT54"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09041"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06446"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000010">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="16">
        <location>
            <begin position="61"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT51655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="235" mass="26544" checksum="7DB8B1EE25B48737" modified="2016-11-02" version="1">MKREKGLNVEQDPDAMAHPGYVSNILHDQKKVGDIVQLSHPAGDFSFDVRTDDDDHSPTVLLSVGVGLTPLTSILNTSIAKPGRRQISWVHVSRNHKTHAFNDHVNTMAELHPWINKRVFHSNPVHGEEQGVHYDHRGRLDLSELDAEKDLKLSDKNATYYICGPEQFMVELEQALREKGVDANHINMELFGTGGVPQQSRDEGIETALTRLESIDYGIWNVRCVWVSNDESNYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT56</accession>
    <name>A0A1C1CT56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09204"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06435"/>
    <dbReference type="OrthoDB" id="10578248at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="168" mass="17875" checksum="5028CA977BAD256C" modified="2016-11-02" version="1">MPFRNSLAAIGEKVDSPSADSDIDSNISLPTTEGSEGTASSSLQGRLTRSSHVRSSDPEAVLALTDDVLGVARGLFALVDAKYADEELLEVQPAGDEFEVADCLDDARCLNDVTAAKKKLNDFKARLRIAKAQAVVAENRLKTAQAQVAFAEDRVNLAIDQLESALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT60</accession>
    <name>A0A1C1CT60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADA HAT complex component 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT60"/>
    <dbReference type="STRING" id="86049.A0A1C1CT60"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08208"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06425"/>
    <dbReference type="eggNOG" id="ENOG502S5YH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5355528at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058706">
        <property type="entry name" value="zf-C2H2_AHC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25909">
        <property type="entry name" value="zf-C2H2_AHC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHC1-like C2H2 zinc-finger" evidence="2">
        <location>
            <begin position="294"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="654" mass="70298" checksum="1BFB8A087C0409EC" modified="2016-11-02" version="1">MLRLLSWTGCDMVNSPDMRMFVSKQDSPGSGGLAKPGAGHKRRQSGDAQGQADRKRARIVEMHQSAAFPAPADQNPTADPAPGIPKTTASNPNNPPSYLPSPPEVKMDDSELCATDSAVKGGESDRLESIRNVIQTQIGLEILLKHKELRLIDQEMAKCQVALEQLRRCHEIPFPGTQGLSTAVSTGTGPALRTSFSTPLPQSPAPWGVLDGPYTRHYAKWLLQDPRFEGGEVQQVESTPIGKSPMKFRSQTRGSFAEGPQTSSQSRTQRGGKLKSLPAGYGQPKEKATGPMIIKRKSDGATVKLVCPDCGRSDFGSAQGFINHCRIGHGRSFASHDAAADACGEPVEVDETGAMIGVEPVLTPTAGNVHPLIRSAKLLQPAPPRTAPPTTARDTNAENTKAKVSPEFKASTLTPNLSDFVKGRGLGLDLQELVSDAKTKIELPESDSEDDDMDIDVPMQNTAQGRHPQVAGSKQPAKPTKSPLSSPLLSSSMLRSTTNLHGGGVQPFVGANGAITQPRPRGMTLPMNDRSPTDLRPSDPSPTSESNQAPSLVDDDEEFEPHSPSSSSISDEHDMGEIDFEVQGDDDDARSVLHGPDFQPTCTQAARPSHARRPSAIRRHGEDREEKHVSFVSPSPARETPHPRVSGDRRKRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTU4</accession>
    <name>A0A1C1CTU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09284"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="123" mass="13528" checksum="DDEBE667ADC6A7AE" modified="2016-11-02" version="1">MLIRAGGVQLETVPEEADSVGGGVAGHLLLQLLANRVSWRTPRAVRDAQPGSTRFRGDDDWSMSVKGARCFKDETVVPKEASNVTIHHTPRRTCSPCATFPIFYGMTFAAFILANAVRWPWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU21</accession>
    <name>A0A1C1CU21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU21"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09285"/>
    <dbReference type="OrthoDB" id="10579030at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="123" mass="13340" checksum="69BBAD0FFF2763F1" modified="2016-11-02" version="1">MAEEGPSQISTCSYIQKTTTFTEEEGMPRIPERAYIKVPYKVPYRSPTPPRAGPLAQAADITSTLVSSSSDMGSPQAQPFPETGTNAHLRGGWDEEECCICCVCSCLACDQFCQETSTGSFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUQ2</accession>
    <name>A0A1C1CUQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09321"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="104" mass="11171" checksum="4562149C412A1D4B" modified="2016-11-02" version="1">MPSSCWLVACIAWRAQDTASSRGPVALFVLSKQCCVHEVSVVTGPHGFVTVGRSGDGTYAGAMQFMNPTGARGPLNRDTRLPDFGTVDSYSSEYHESQTDRSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVH7</accession>
    <name>A0A1C1CVH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">glt1</name>
        <name evidence="27" type="ORF">CLCR_09420</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="24">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="19"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVH7"/>
    <dbReference type="STRING" id="86049.A0A1C1CVH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09420"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03910"/>
    <dbReference type="eggNOG" id="KOG0399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097054">
        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000006">
        <property type="entry name" value="Glutamate synthase (NADPH/NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000022">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 24" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16 24" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="26">
        <location>
            <begin position="53"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="2118"/>
            <end position="2152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="23">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1183"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1189"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1194"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="OCT52513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="2152" mass="237725" checksum="CE78CB622C595E59" modified="2016-11-02" version="1">MGSVAEERRQQEIATEEVQEEYTPYQPEKGYGWGEALPQKQGLYDPGLEKDACGVGFAANIKGKASHKIISDARNLLCNMTHRGAVGSDARDGDGAGVMTSIPHKFFVKNFAREVGVELPPLGQYAAGNLFFKPDTEMLKHATLSFEEAAQSLGLRTLGWREVPRDSTLLGPAALSREPIILQPFVVLASAYGTGNAPENTDPEQFDDAEFERRLYILRKTVSHDARWKPWFYVCSLSNRNIVYKGQLAPVQVYQYFHDLVSVDYEGHFALVHSRFSTNTFPSWDRSQPLRWLAHNGEINTLRGNKNWMRAREGVLKSDLFGEEIEKLFPIVEDGGSDSAAFDNVLELLMMNRVLSLPEAVMMMVPEAWQGNSAIDPAKAAFYEWAACLMEPWDGPALFTFADGRYCGANLDRNGLRPCRYYVTDDDRIICASEVGTIAIEPERVIIKGRLQPGKMLLVDTEAGRIIDDAELKATVANRQPFQQWLNKLLMKMPDVVDAVSKEVDLGYKLSDDSIQEDARLKAFAYSFEQVSLLLGPMAADSKEALGSMGNDAPLAALAQQPRLLYEYFRQLFAQVTNPPIDPIREAIVMSLECYVGPQGNLLEMDESQCGRLLLPSPILEIETLNAIKNIQTYNPDWSVRTIDITFEKEDGIDGYMKALDDICDEATAAIDQGDKVIILSDRAVSADRVPVSSLLATGLVHHHLIRNKWRSRVALLVETAEAREVHHMCVLVGYGADGINPYLAIECILKMNRQGLIKKKLTDQQIIANYKASCDGGILKVMSKMGISTLQSYKGAQIFEALGIDDTVVDRCFAGTATRVRGMTFELIAQDAFALHEKGYPSRHVRSIPGLAESGEYHWRDGGEPHINDPVSIANIQDAVRTKNDKSYEAYSLSEYEQIKHCTLRGMLDFDFDQRAPIPIDQVEPWTEIVRRFVTGAMSYGSISMEAHSTLAVAMNRLGGKSNTGEGGEDPERSLKMENGDSMRSAIKQIASGRFGVTSNYLADSDELQIKMAQGAKPGEGGELPGHKVSQSIARTRHSTPGVGLISPPPHHDIYSIEDLKQLIYDLKCSNPRARVSVKLVSEVGVGIVAAGVAKAKSDHILISGHDGGTGASRWTGIKYAGLPWELGLAETHQTLVLNDLRGRVIVQTDGQIRTGRDVAIACLLGAEEWGFATTPLIAMGCIMMRKCHLNTCPVGIATQDPVLREKFQGTPEHVINFFYYVANELRAIMAQLGLRTVNEMVGRAELLKVREDLRTGKTQNIDLSLILTPAHSIRPGVATYNVRKQDHKLHTRLDNKLISESELALEKGLPCRIETDIVNTDRALGATLSYQISKRYGEAGLPQDTIHVNIRGSAGQSFGAYLAPGVTLELEGDSNDYVGKGLSGGRLIIYPPRSAVFKAEENILIGNVCLYGATSGTCYFRGVAAERFAVRNSGANAVVEGVGDHGCEYMTGGRVVVLGSTGRNFAAGMSGGIAYVLDMNQDFHSKINMEMVEVSGVETPEEIAFLRGMIEDHHHYTGSELAARILLEFNRALPRFVKVLPTDYKRVLAEQAKQAEEAKKAEYPLPILPGNPVRNLHQEQREIRHDKEAKQQKANMLDIEEGVNGDAGQAKHKAALVLDKTRGFMKYARRAEKYRNPKTRVKDWAELNSRLNEDELKYQSARCMDCGVPFCQSDTGCPISNIIPKWNELVFQDQWKDALNRLLMTNNFPEFTGRVCPAPCEGACVLGITDDPVGIKSIECAIIDKGFEMGWMVPDPPQERTGKTVAIIGSGPAGLAAADQLNRVGHTVTVYEKSDRAGGLLMYGIPNMKLDKRIVQRRIDFMAAEGVQFKTGVMVGPGEEVSLDSLRQEYDAVVISTGAQVPRDLKIKNREAEGIHFAMEFLHANTKSLLDSELGDGHYISAKDKHVIVIGGGDTGNDCIGTSLRHGAKSITNFELLPQPPPERARDNPWPQWPRIYRVDYGHTEVKQHYGKDPREYCVMTKDFDVKDGRIVGINTNRVDWTKSATGGWDMKPREGSEEYFPADLVLLSMGFLGPDDRLFEGQVELDPRKNIKTPKNMYNTNLPGVFAAGDCRRGQSLIVWGINEGRQCARQVDSFLMGEGSILPVTGGIIQRAQHDAVPRPKESKAHKGGDMAHAAEDFKRGTEIKVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVL1</accession>
    <name>A0A1C1CVL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Anaphase-promoting complex subunit 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cut23</name>
        <name evidence="10" type="ORF">CLCR_09646</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVL1"/>
    <dbReference type="STRING" id="86049.A0A1C1CVL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09646"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03906"/>
    <dbReference type="eggNOG" id="KOG1155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="22"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="398"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="432"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="466"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="500"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="550"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="614"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="622"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="661"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="679"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT52509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="780" mass="86770" checksum="70ECABCF2ED1ABBC" modified="2016-11-02" version="1">MAPRQQESFGSVGELDTEVVSELRDRLTEAAIKCSERCLYQSSKWAAELLDSLPEAGYTDGDSQIHDMLSAQSLYRSLTTSYDDPEEAALEAKEAPKYLLAKAFFDTKEFDRCAAVFLPPAIPAGGLAIFDKPKGRTPTSTPSKAKGKSKHNDKAAVNPFPNISQKSLFLALYARYLAGEKRKDEESEMVLGPADNGQTVNRELAALARGLEAYFGARDAADPQLKRSQGWLEYLYGIILSKSRQEQLAQQWLLRSVRVNPYHWGAWEELASLLSSIDDLNAQLSPSVLPQNLMSIMYQAYASVDLFSTSDQYTTLNYLRTLLNYFPKSTFLLTQLALSHYHAKEYESSAAIFQELLVTHPHRLDGLDHYSNILYVMADRPRLAFLAHLATSVDKFRPETCCVVGNYYSLCSQHEKAVMYFRRALTLDRSFLSAWTLMGHEYIELKNTHAAIESYRRAVDVNRKDYRAWYGLGQAYEVLDMGFYALYYYQRAAGLRPYDPKMWQAVGTCYAKMERLDQAIKALKRALVAGTYFEESSSVQSSFNANASVSSNVAPSASRGKSGPGTKSQQQQQAGRKLLDPETLYQIASLYERLGPEGEAEAVRYMELCVAQETGGSHKSVLKAEKALKKRQRKEERRNAAAEERRARLSEMRAGDAANMDVDDGEGQGDAGGDDDTEVLSSSPTPDDSGSQGSDNEDESAGPEDGFGTGTTATTSKARLWLARYSVRIGDLERAERLAEELCMDGYEVEEAKGLVREVRGRRDPEGGIGMTSGLLQSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVN2</accession>
    <name>A0A1C1CVN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10956"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="84" mass="9136" checksum="9AB1CFD0C2576556" modified="2016-11-02" version="1">MLAKKGQTGSSYRVMLVFRTAHEVESWKPSKSHNLVAEDEQGGLVNKPTGSSLGSGSSATCLSSVRNYDDPKNGPRHDPVHRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVN7</accession>
    <name>A0A1C1CVN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11038"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="111" mass="12026" checksum="852D15D67D4B75D7" modified="2016-11-02" version="1">MCDLYSSLRSERYSDISSVSTGGIEAKNGPWWSLPSLSSTKSRSQACVLSALFSTLLTLAFVVLIKSAMLIEISGLRMLTASLYFSTSKNLKPTDVEMAIDEFVLCAGQGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVY7</accession>
    <name>A0A1C1CVY7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">lap2</name>
        <name evidence="18" type="ORF">CLCR_09817</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVY7"/>
    <dbReference type="STRING" id="86049.A0A1C1CVY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09817"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04081"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000054">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF57">
        <property type="entry name" value="PEPTIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 18" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 14" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 14" id="KW-0732">Signal</keyword>
    <keyword evidence="11 14" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008448732" description="Peptide hydrolase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="16">
        <location>
            <begin position="121"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="17">
        <location>
            <begin position="232"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="462"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT52702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="533" mass="55178" checksum="D1F08D7D61656F53" modified="2016-11-02" version="1">MRPLTLPVLAALAASCAATHPTLPPVTSEALQALISLDELTSGAKQLQAIADAAGGNRVFGSKGHNDTVYFLYDTLLATGYYDVYLQDFVELFSGGTSSLTVNGETMPASLFTYDSSGSASANLVAVSNLGCEVADFPPESANAVVLISRGECPFAQKAANAAAAGALGALIYNNVPGAISGGTLSEPGDYAPALSISQEDGLALLAELDAGAPVAVELEVNAVLENRTTFNVIAETKGGDHDNVIALGAHTDSVEVGPGINDNGSGTIGILNVAIALSNFAITNAVRFGFWSAEEFGLKGSTHYVSTLNQTAGETAKVRAYLNFDMIASPNYAYMIYDGDGSSFNLTGPPGSAEIEADFEAFFTSAGQNFTSTAFDGRSDYGPFLENNIPAGGLFTGAEETKTPEEVAAFGGTADVAYDANYHQPGDNIDNLNLDAFLLNTKAIANSIALYATDLSKIPPVSATGPTKRVRDVYSRDAVRTTPRQKRASGLKPHARTRRGPASTIPAGSCHVSTKEQNKEGTGAGTGLPATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWB4</accession>
    <name>A0A1C1CWB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_10923</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWB4"/>
    <dbReference type="STRING" id="86049.A0A1C1CWB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10923"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT52728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="151" mass="17174" checksum="0A3F2FAF9D6CC73F" modified="2016-11-02" version="1">MDISSLLNDVRPKQSETTDFDIPGDTLRISPKCTATNVNVKVRAEALGDQTPLQSHKHSLRHWQAPTKRTFPKDEQLTPRQHEAEAQGSAHDRCQNITRPKPKRKFSRRTKTGCLTCRRRKKKCDEARPAFIGKNCVKGGFPCDGYDPRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWK7</accession>
    <name>A0A1C1CWK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SIR2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09514"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04273"/>
    <dbReference type="OrthoDB" id="4130938at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1008" mass="112454" checksum="85AF3797E7D58C46" modified="2016-11-02" version="1">MGKTRTLLDSAAAAGLLSFPTQVAQHVYEANNLDGATEWVESFTEKAKGRATLFLGAAISTFKPTQLPMWNDFVQLLWASALEVATADMRPDRVSEGLLAFFERARDRVPNYMVTEVISRRLGQQYLHVLDAFQAERLQDGTYAFNEIHKWAANLLATGAVAAVMTTNFDNYLEKAIEKRTPLCYQITGDPHVDGREISSRLSLTTAKSSLVLVVNGAKAFAFVRSLMPQLGNGKVTFLFKVHGSCYDPVSCIDTRLQRAQGLPSFATDVLDILLKRTVWLVAGFSGSDMNDNLDYLRFISSKKEAAIIWLTYPGSRWESAIHRLTAVMTLEKGSRTGFCLVNGHFLGERHSEESKFPQFGQKILKWAQNLGPDWCKLLLVDLVALFEEKAEQTAPPQLLQAFNQGTSPRQDWNTILQNMDLTAEESQDQIAPAQSCSEVWALVNDALRADHTWQKEARQDLGRRLTAGLEVLGGHHIRLQEAASRGDHPQVHAQAWVVSALSGLAMLCGGQVDGAARALEISSGIAWLVGNFEHHQMIERLLKAIFQAPHPSTDAEEGDDAPARNQTVGCLAFSPAMDNVNSKMNKYGVPPQNYMRALLHRSILFADGMILPANIISNSTVLVDEVLFQGERDELNEVYLRHLYPALPTEFKDGPGKLRRFLDSRPKTFIFESVNDDHIARMDDFFDDPANAHQVLYFDESLLGRNYGKYIRTAVDPLHREATVAHLVRLWKHVEAGGGWSEHPDHSERSSAATHAAEDLTDSLLLLSTLLPEAVRRSPLYKFADLFDEASDRDSILAFLRSDAGEEAKLQLLKARDRIIEKPWLYSPFCHELFDAPYRAALAFDYASRAAVEPVLFLEEDEIPSWEFMSSDCHSKAFPTNFAAFPISADSHKYSSLLLSQMTTATLRKARRDLAPFRAKIVEGSPLVEDDVVRMKDAMASFESRSLALPDVEINALVDLDPNVKQVAELLLAQCVFLVRNGPPLDPMYEEAQIALPGLLALRRQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWR5</accession>
    <name>A0A1C1CWR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DCW1</name>
        <name evidence="12" type="ORF">CLCR_10160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWR5"/>
    <dbReference type="STRING" id="86049.A0A1C1CWR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10160"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04245"/>
    <dbReference type="eggNOG" id="ENOG502SMCE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651110" description="Mannan endo-1,6-alpha-mannosidase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT52905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="459" mass="49813" checksum="393CF78B307F9830" modified="2016-11-02" version="1">MPGLILSVILFLGFLSRTAVGIALDVDDTESILAAAALGAHKVIGLYSGNQTGGTQGKWPFPPYYWWESGGAWGGLMEYWHYTGDDTFNEVMQEALIAQLGPKKDFNVPAEAFDTGNDDQAFWVFVAMAAAEYSFPRLPAPNPSWIQIVNNAWQDYVFRWNTSGCNGGLKWQFNPNNAGYYYKNSISNGAFFQLSARLARFTGNETYVHWAETVWNWARGIGLIDSIYNVYDGTDELINCTGIDHHQWSYNVGAFLYGAAVLQNFTNGSSPWIDRTAGLLAATNTFISPFQNASNMMFEAACEISNTCNTDQLSMKAYLIRWMAATSKMAPFTAGRIGEVLRASAQGAAASCTGGKTRNTCGSKWYLGRWDGTTGLGQELCALEATYALLVNQTNPPAVYPHVGISTAAPSPTIPVTATDSLPAASDSARPLHDGAPATPSTMQTKVLIAALFTSLTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWR6</accession>
    <name>A0A1C1CWR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWR6"/>
    <dbReference type="STRING" id="86049.A0A1C1CWR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10946"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04329"/>
    <dbReference type="eggNOG" id="ENOG502SE6U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3827557at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609">
        <property type="entry name" value="RFEG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="121" mass="13971" checksum="4CA990C97528F2D1" modified="2016-11-02" version="1">MPQSISPGNDYWISGYGLSRHIVLRQLQYFLGPGATVRPYSYHGREGFLINGPQLTKEQIEDLKRQSEQYERQQTMRMSNRASSGTDDDDCDINEIVSISASRRHSPTHASASQYRRERHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWZ7</accession>
    <name>A0A1C1CWZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10736"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="249" mass="26544" checksum="B5B7B9081B9E104E" modified="2016-11-02" version="1">MSNRDPLEDCFDAGNGFCSRSRGPLQPSKGDHIDAGNGFCSRSRGPLQPSKGDHIERRPGVRPIKPPQTFNSAVWFCCACSVLGQGFSFRQRACSSCRHAKCRACPTEVTGGGGPGGQGPTATANVHSGSLLADGYSSSVSLEDTTIHTVKSDELIGIGSAFQTDIAALDTFSLSSDNAAGARTLYGQNWTASQRVVASDSGEWSLMMMDAAVDVNTFEEDEEEEEEQDPILSDRRLDAESTRANCGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXB0</accession>
    <name>A0A1C1CXB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho-related protein rac1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rac1A</name>
        <name evidence="6" type="ORF">CLCR_10858</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXB0"/>
    <dbReference type="STRING" id="86049.A0A1C1CXB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10858"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00081"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01871">
        <property type="entry name" value="Rac1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT53106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="178" mass="19694" checksum="C132EE4E7F2BF4DC" modified="2016-11-02" version="1">MAQATQSIKCVVTGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSASVMVDGKPVSLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSIVSPPSFDNVKAKWYPEIEHHAPNVPIILVGTKLDLREDKATADNLRAKKMEPVSYEQALAVAKEIKAVKYLECSALTQRNLKSVFDEAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXJ2</accession>
    <name>A0A1C1CXJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10967"/>
    <dbReference type="eggNOG" id="ENOG502T5Q3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4160857at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="87" mass="8432" checksum="02E8ED6343EE77A0" modified="2016-11-02" version="1">MPGIPLDAMDKIKALFKRKKDKESGTAGTKTDTNGTAAAVPKPTPTDTAAAPSTSDPAAPPASAAPVDASAPAAPADPAPANTPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY15</accession>
    <name>A0A1C1CY15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RIB3</name>
        <name evidence="14" type="ORF">CLCR_10716</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY15"/>
    <dbReference type="STRING" id="86049.A0A1C1CY15"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10716"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00328"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT53361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="258" mass="27914" checksum="897E2A8515802CB7" modified="2016-11-02" version="1">MQPPSTVAKGFDSIESTIQAFGNGEFIVVLDSQDRENEGDLIIAAQDVTTEKMAFMVRYTSGLICAPITGQLASELDLPQMVVDNEDPNRTAYTISIDSNDESVTTGISAHDRALTCRTLASPKATAASFRRPGHVFPLRARDGGVLERTGHTEAAVEFCRLAGKAKAGVICEMVDDGEPVPGQTIMREPGMMRRDACLEFGRKWGLRVCTIEDLVEYVRREKEQEKEKAGNGQAHGNGVVTNGVNGVNAANAVNGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYS7</accession>
    <name>A0A1C1CYS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10825"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00637"/>
    <dbReference type="eggNOG" id="ENOG502S2QC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="22"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="212" mass="22540" checksum="256117914179252B" modified="2016-11-02" version="1">MANAVFDPSDPTSPLSVSPHETALLLMDYQNMLRGRVGEGAWASVTNIASGLRDWALEKNITVLHCLVDTSPGTKPPGYSRTATRWKAYEAAFAATPELGRESELLAVRGPSNVEATFVRTPGYISALESHGLAEVLRATGIRSLILGGISTSGCVLSTARAATDRGFIVTVAEDACFDPVPGLHGMLATHVLPTSAHVATSREIRDAWRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ02</accession>
    <name>A0A1C1CZ02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ02"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ02"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10900"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00700"/>
    <dbReference type="eggNOG" id="ENOG502SJWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="174" mass="20501" checksum="4904999235F1BE4A" modified="2016-11-02" version="1">MFVAVCLGYYHYGQLLYYPYLHGDSYDDTVQARHYADKCKSHSIGLCEILYRAYSTAGCEVYDTMVGHVLVIASTVQLHILLFSSDEAQIRAARSRLERNFEILTRLQWPTLDVCFTRFREFHQACQKYKETSFRMDRWMHRFLFEFAKPIGEKDTDDLAELIPWTLQELGFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZM0</accession>
    <name>A0A1C1CZM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_09767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZM0"/>
    <dbReference type="STRING" id="86049.A0A1C1CZM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09767"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00873"/>
    <dbReference type="eggNOG" id="ENOG502RSGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3945378at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651166" evidence="3">
        <location>
            <begin position="25"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="614" mass="67862" checksum="5E8192E6DCA16F0A" modified="2016-11-02" version="1">MGRFAHSLLLLLVSFLIFSSLGYALDSDNETAESVCQGVGPAEEGCPLQGNGDFYGMGVRIGIYFQWITSWLANNFLPEEIIGSLDTNSIFLLALFSTVFTYSLQGTSIRVVDVLLIHQLCTGFLFSVMSLWGYRTMYYKTEGPGGRRHFGGFGTHFRLVLMSAITAYGVWFWIRGVDTLAMCDSRKDCGGLETFFFVPMKVNSKVTRGINLVMAVGAAVYYGAMAITAIVAGMVATVRKLGGKEIYWQLVVRPDRDVALNRRELTVWYIFLSCFNLFWLVFAIASIEVTLNLNHIQNVLGAGGTRGAGQVIPALIGLISFFRVLYELACQHVPWLKKKGDEEEDAPDVYDLASPTEHKDTNGLGLTHGAYSSALLNDDPAQTAGVSATLNRPPTILYPLHRTTGTHRRPRQTRRSLSHRILLAWLPWLNMFHWARQSLTPDLIRNSAIFSSSTNAGHGREREKKKNNAGFEVLGVKRMSFSTCDQDADARQYRPGHVRAQSSTTTTTSDEGPATALLAPSPSQRSHSAGASQSQGQSQGQNQSQSQGQSLGLMTEVTDQLDIELSTRQRQWQWQRQSRGHRRMSSESTADVGTGTSIGAYEGKGYDDDYDYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZQ7</accession>
    <name>A0A1C1CZQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-dependent kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_10213</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZQ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CZQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10213"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00866"/>
    <dbReference type="eggNOG" id="ENOG502S25T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2359117at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039198">
        <property type="entry name" value="Srl3/Whi5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246:SF1">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="214"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="341"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT53958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="46013" checksum="46B32F9500246697" modified="2016-11-02" version="1">MTDTAEPADPGMHDASAHASTKEDPPQLTSVAANTASIRPPRDSAAPEPSEPSRPADLTLSTSDVASNTHNPPADAEELTPPTSAISSPDASQATESLSQPESSQSAAGTIGHDKTGDTRAGSSSQSPTPEFASGTKRTASGEVKRASVNGLGEVLAKAGGARHAHTPSTVSNGAKGNVLELSQQLRTKLKYAMVKVQNGWQTRSLDEVESLASQSPRSTVSGFQQLHDHHVLSPRTAMSRKYQRESSESDSSDTTGALESLGLATENSQVPSRRALAPPVDIVPGSRRRPTPNAAYHAVNGSHMQSRTLHSRRPPTSQRTPSQNAAMEADAVETLLFMASPNNSGYNPTSHASQESSLRTAQAFSSQTSPLRTQFSQASVTSPKKVGFSDSESSAPAFDKAALIDRMLDELSDDSDAELEYAFTLAEKGKMAASVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZR9</accession>
    <name>A0A1C1CZR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">deoxyhypusine synthase</fullName>
            <ecNumber evidence="6">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_10267</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="6"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZR9"/>
    <dbReference type="STRING" id="86049.A0A1C1CZR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10267"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00950"/>
    <dbReference type="eggNOG" id="KOG2924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT54053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="370" mass="40229" checksum="E09AB953A8DBCC7F" modified="2016-11-02" version="1">MGSAPPTKATDAVLVASEPVPDGVLQVKGIDWAALPDEHRAIISNFVDQLTGQGFQSSSIGDAIRIINEMRSWRDAETGDRTTIFLGYTSNMISSGLRETFRYLVQHRHVSAIVTTAGGVEEDFIKCLAPTYMGSFSASGAALRAKGLNRIGNLVVPNNNYCSFEDWVVPILDKMLTEQEEEFAKSGERFMWTPSKIIRRLGKEINDESSVYYWAYKNDIPVFCPALTDGSLGDMIYFHSFKASPLHLGIDIAQDIRKINTIAVRAKRAGMIILGGGVVKHHIANACLMRNGAESAVYINTAQEFDGSDAGARPDEAVSWGKIKADGDSVKVYVEATVAFPLIVAGTFAKPSRSREEDLVADPATATATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZU5</accession>
    <name>A0A1C1CZU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative DNA polymerase theta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_09557</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZU5"/>
    <dbReference type="STRING" id="86049.A0A1C1CZU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09557"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00905"/>
    <dbReference type="eggNOG" id="KOG0950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057220">
        <property type="entry name" value="DUF7898"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25453">
        <property type="entry name" value="DUF7898"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="153"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="407"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="919" mass="100659" checksum="E0FC20727B0B15EF" modified="2016-11-02" version="1">MAAPWQQLATSYGQKTSVDLARQQTFNTTTTAGVKRTIDEVQSAQDDQLGLPIHHRTVPHSAQAPAQVESHEHRPPRLQASRIVSAVGNSTQAVTLSTAAPLASTGSTPGPSQNPLLSLRHPRYGLPEQLVENFEALGVHAIYPWQSSCLLGKGLLTGEQNLVYTAPTGGGKSLVADVLLLKRVIENPTKRAILVLPYVALVQEKLRWLRSLVDGVFKVSDDMTDGSPLPTWRRPSTTVRVSGFFGGSRSNVNWSDCDVAVCTIEKANSLVNTAIEEGKHGDICVVVLDELHMINDEHRGYLMEILATKLMALETPESKVQMVGMSATLPNPQLLAQWLRAKFYVAKYRPIPVEEHLVYENAIYPTANAKEFFRTASQLTTKDAMSTPRPQPQRTIQRSTHHELGNPLTNAAVALAADTALAGHGALVFCSSRMGSEKTALLISDALPTDHVDQETLDKRQDLLASLRALPAGFEAAFSKTISCGVAFHHAGLTTEERELVTEAYDKGVLKVMVATCSLAAGINLPARRVILNGARMGRDLAGPAMLRQMRGRAGRKGKDEVGETYLCCHKSDLEAVAAVLEAELPPVESCLTPEKQGISRALLEIIGTRMASSKSSVDDYVRSSLLWRTMDHAQVLDMVEKAIGGLRAKHLIQSGQYDDCFEPTKVGMAVVASGLGPEDGVFVHSELRRALESFVMDGEMHIFYLFTPVQTAGLAEISWLTFRNQLEGLDESGMRAMRLVGVNPAFVNRLVNSGGALKENTADEIRLARVYRRTYSAFQLRDLCNEMPVHEVSLKYSVPRGQVQTLSQNCHGFAAGMIKFCERMGAREDLLEMAQVAFVKSRMARIFWENGFKSIRALGEADPQALVPVMAQAQARKMKLQGAAATKFSAKLLSKAEIIVSSANRLWVKHQMAQWEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D037</accession>
    <name>A0A1C1D037_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nuclear pore complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_09436</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D037"/>
    <dbReference type="STRING" id="86049.A0A1C1D037"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09436"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00894"/>
    <dbReference type="eggNOG" id="KOG3630">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248320at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000645">
        <property type="entry name" value="Putative nuclear pore complex subunit Nup159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="5">
        <location>
            <begin position="60"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="465"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="665"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1419"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="477"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="752"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="766"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="804"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="839"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="894"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="930"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="968"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1013"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1125"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT53990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1519" mass="159749" checksum="C29A34E7CD0B3420" modified="2016-11-02" version="1">MAFSFSNAVSGGSASDIAGASVRDGPELKEIQTNELGFAAINGEAKVQLLPQSWADDNMPPPSSSLLSVASAKGLLAAAGPDAVYITSTKKVREAFQAPPPEKSQTRTYSPEIKLDYPHITQVSFSSDESVLVISPSTGGVVAFQVENLQRGHLSPALEIPADGQSLRALVPNPTAESAELFAIVTTNGDMMLLDLKAGAIKAGNDGNVLKSGVSCLSWSNRGKQLVAGLADGTAVQLKPDGTVVANIPKSTSIPAGSHVSGISWLENDTFFIIYTPTDTSEGNQPSDYYVVQREPKTTNYTFQKLPEVLPPYGVERLPSFHFISRLRNFPPHLQDLLLLAATAATDVGLVSKSDKALSQDEPVMGAFTFTMVEDDSRRAQLPLTSKMQDTSPVGMVVDLSSSERVPNPIPSDPEIEETDGPVPCLFILNNEGVLVAWWVIYNDSVRQKTAFSGFASVQAAKQVTAPTATSPPPPSTITTSTFGTPATANAFAKTTGSTFGTQTTQAPLGAPSMKPFGASSPITSDKPSWTSTGFGSTNDATASTTFGQPAFGSATPMGSQAAAFGSPSAVGSRTTAFGQPSAIGGGFGRPSTIGTSSFGQASVAGASGVASPFAGAGAGASGSGFSSFSKGGFASFAGGASGLENKSPFAAAGGANAFSQNSGNLFGGDNAQQSPFATKAPGGNLTSFASTAAHGPPFGGKKASDAPGPFGAGNVFKLQSSFTGDGSAKDDLPPPKEPGFSFGSAFGDMLGESKRAVSPARDKEAEMDEESAPSEADSDNAPNTSFHGFSPHADTKAPHTLVTPPSTLTQSKATPAPPVSHLFGPTQQDNTTPDHKINSTGWPSNALSSTTPKETPNPAHLAMFGTKTSAQESPAVVQKSEPAPAFQPIRPAPEIKKEPPSDDESVDMKKIPEAPLPPDTVSKPRYASGETSASSNVSKATSDDAPLPPDFLPVPMARQDENNQALPEDDEDDFSSDFEDEGPEGEEGEEQGGEAEEDEDSQSEYVKLQEGEQLQTSPESSFKSGDRSPDTSPTGGLFTKVASTSTAPKPARPLFGEVSAAPVFAPPKPHESPRSPSPIRPAFSADGLRPDPSRSVSAPAHPRSVIDQRKAQYQQSGLAAQAARMREEEAAKEKARREALAREKTQAEAEQLAPLEDDEDERMRQELDEPIAPSQTLDDFVPIQPRDPEETSKSGIPAQIERLYSDINSMVYTLGINCRSLSAYMKYQHPDATNLSWPGVLKSDTPMDALNDERFLTDITRLHEGQAVLYSMLAGCNVEEYLKHSGEAQASLKKEVFDLRNKLMSIRKTIHSLSTSDGAASAPLSAEQLSVQHDLRKSFTSVQTRMVQLEDAITVLRAKLVQSSANTQSGALGRSASQKKPTVEAVTKTVGKMMSMAEQKSADIDVLEAQLKKLNVHAGTSSIGNGDAEVPATPPRSRHSVNGGTPGSAGSVYHTPDSNFGSGTRSRRGFRTSQNGGLPAVSAEDMQRWQAKAQRRKAVASMLKDVLEEKRKKTIVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0H7</accession>
    <name>A0A1C1D0H7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OSK2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_00778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0H7"/>
    <dbReference type="STRING" id="86049.A0A1C1D0H7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00778"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01617"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="942095at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000434">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="503"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="730"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="735"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="749"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT54343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="813" mass="89229" checksum="F28B4CCCD72BC99F" modified="2016-11-02" version="1">MRPQVVLKASNKSDPNLAREIHHHRQFIHPHIARLYEVVITESLVWLVLEYCPALNKALGDELYNYLCKNGALPVETVQKIFTQLVGAVAYIHSKSCVHRDLKLENVLLDKHDNVKLCDFGFTREYEGKANYLQTFCGTICYSAPEMLRGEKYAGEKVDVWSLGIILYALLKGELPFDEDDDAATKAKILKDDPIYPDTFPDAAKTLISKLLSKRPLHRPTLSDILADPFLADHAPQQQAILKLSQPAVFSTQLEKDTLERMKSAGVDIDKVIENVLAQRCDALAGWWALLIEKETRKQARKERKRKDRDAEMKILRRLSGASSRLERIAPTLLEVDEEHSPGDVEPRRSSSRGRTQRRSTPQILVSDLPQLPEGDVMKSPKSGAGTPPPPPIDKDSVRSNSGSRPPLPPKERKRRSSTLQLVTSNPDLLGPVNGVSKRRSGRFRNRQFMSQLTALKHWFVESTKRAKSPVLNGHSNNTSKATLPNNALQANKSSRNVAANLNRSSMGSTLTPTLSNSRPLTKLSTNAPLVDTTRAGVHRKSLSPSPITPRSSYRRSSTGLRGRKSTSSSVSSIRSMPRHGTSHSKASSQSSNSIDTIHSPTSRSVSIGGRSPHSSIKVLPVTPTANAFPSNIRLVRTPRGSDAGLPPRPLSGLGADLLSPSPGTPQADAFGSNVMFARRKKSPFKGPTLNSAFFSASTIPAAFGSPAVLGGGGRQREGSDGKPNLGLKDFIGGAHRKGSSSKRKSQIIEEEEEEEEEQAVVEEEEDEVEEVEAFQAIHLNKGERLDSITIWNDAVTEEAEDSSVKIHSGTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1F8</accession>
    <name>A0A1C1D1F8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_01013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1F8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01013"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="91" mass="9852" checksum="20764DF03330EB1D" modified="2016-11-02" version="1">MKCLATIGTCRAGLGDIRRLPGTTSQEQALCRYLFRGIIRPATFDALDFVIALFGLFAPLSGSIVRADELEQNSGGGMILLERTCTDLSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1H1</accession>
    <name>A0A1C1D1H1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_02728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1H1"/>
    <dbReference type="STRING" id="86049.A0A1C1D1H1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02728"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04694"/>
    <dbReference type="eggNOG" id="KOG4711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF1">
        <property type="entry name" value="DUF2421 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="704"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="726"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="788"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="672"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1035" mass="115478" checksum="94C0BEA7758FC940" modified="2016-11-02" version="1">MASSSEDSDPDLTNLNPRASLRQSSYIDPSTGARLSKTFTLHNFDPFDGSRDNADEASPLLGQSREADTSTSSKHGWLLSKSLEFGKQAKQFLLSDTGKGVFKCALAYLLGSLATFVPQLSDLFGRQNSKHMVATITVYFHPARSLGSMLDALILATTAFLYVALVSFMSMSVAAFFADTVHLLELGHAIVLVFFVGGGLGLVAWVKLKKNDPLVNIACSLVSLSLVTILTKEGAIQAGDYSTKSILQILKMIVAGVLATMLVSFLIFPISARHKLRKNLIQVTDALADMLALITSSFLSGDEAELEDHVLQEVSDQHKKASSTITQNLKEARYEHYLSGTERQALIEARLSQCIQRISQSIGGLRSAAAMQFVVTKQPAFGSVQSTAQHPATPGWMDSMESSRIIANDRDILSYFTPLSPTLTANSQRGSAQPASFRSPAQIFELFIQNLGPAMRSLAFTLKEILDDCPFDASKRYVVTTNPKFKSSLERALDLYRNSRRQALLVVYSQKDMDRSRPIPVQADWEDAAACCGHFSYSLVEVAESVHQYLIILDELQLEVDEQPAGKTWRWLQFWRPLHGETDLDGLEPDFAKSVKKSDEAEVQLSNKNLRVGRHHDEPHWPDQPRVKQLFFRYLYAAASFLQRDDVRFAIKVGLGAMLYAAPSFIPATRPIYQHWRGEWGLVTYMLVCSMTIGASNTTGYSRVLGTCLGAFLAVAVWEISRENPVVLALLGFGMAYWTAYIIIGKGKGPMGRFIMLTYNLSALYAYSLSGVEDRDDGDEEHAGKHPLIVTIAGHRVVAVISGCIWGLIITRAVWPISARQKLKDGLALLWLRMGLIWKRDPLATLTEGLHPDRYMNLREEFYLQRFLANLQSLAETSKSEFELRRPFPHAIYSRILKTTEQMLGSFHAMNEVILKDPHISRGEEALLKATVNERAQLCRRISHMFSVLASSMKLEYSITSDALPSIEHTRDRLLAKVFEYRRSDAQEQKVKDEDYSLLYTYALVTGQLSLGIESVLREVENLFGVLDEEALRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1N5</accession>
    <name>A0A1C1D1N5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1N5"/>
    <dbReference type="STRING" id="86049.A0A1C1D1N5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03035"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04795"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="285" mass="31042" checksum="15BBC830E0BCC765" modified="2016-11-02" version="1">MATATPFGRQMRDEHFAFAKSYTPLNHGSYGAFPPGHPLVSTCNPRADRVPVPIDSSGSPLAPSSSSPAPLWPACSMFRGRRSSSCPMPPRGINTVLRNLTRNEGDVIVYFSTAYAACEKTVLLHICETTPASSVRIDVSFPQRGRRPRPSLQATPSKGSIRNETSASKSPCSTPCARFPGSGCLGRPWYRRASSLGVLSLVDGAHGIGHLDLSRLGQPDLDPEFFTTNCYKRLFTPRGSDDDNNDDDDDDDYLGDLFAWAATVDMSAYLCVPEAIKFRSRTCGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1P6</accession>
    <name>A0A1C1D1P6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_02780</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1P6"/>
    <dbReference type="STRING" id="86049.A0A1C1D1P6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02780"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04907"/>
    <dbReference type="eggNOG" id="KOG2604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="50"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="216"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="420"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="716"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="764"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT54813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="787" mass="87731" checksum="4ACA5CE7F6DD9924" modified="2016-11-02" version="1">MAETTEPAEAAKKDGLLAQLEEGDTDLALFKLSGDIDDALLDASLDEYQQYLDQLDAARSHLDTLLASTAATLSELSSISASFRSIDSQTKSFQAQSASIREEQHKNEAIAQDIADNLRYYEPLERITRRLNAPQAGNFVRSQDFSDMLVTLDECIDYMQTHPAHKEAESYRSRYKLLLTRALTLVRNTFMAGVRETTTEVAGRIAAKQLNDTTMSALLYAKFRVGATEMKELGLEIQKRANPPADAEPGTEGEYQSLMNELHASFAACRGRLILPIVHKRLAETAQLPSSKDLVPFARAAISYIRGICLDEFELWAEWFHGYRGLYDFLESLCEPMYDHLRPRIIHENKLAKLCSLVTLLQTRYLHDEEEDGAPDLNQLDFSALIQPALEDAQTRLVFRALAILREEIEMFKPKPEDLDYPRLTSAPPVSASKAALSGRRGSRDPLTSLPKTSITDLDEDSAEEGLFSWTLSASRRSALKHSYPTLSRSIRLLSRIYRLVNSSVFDDLAHQIVHQTTLSLVSASSQISTRSSPADGQLFLLKHLLLLKSQIVAFDIEYVTPDVSFDFSGVASTFWELRERGGLFNPATWMRLFSSGGLLPKVVENMLDAKQELDGRLRQVINEFTAGFARSMCKDLPRAVDKVGGKKADRETVLAEAVSKTRSTIEKEIPILRAKLEQYLDDHRTRETLVAAVEDQVVQIYEAFFDDYAAQSASAAAKGQNGKVNGRSATPISRKGKGPEDAVWDTDTFAEWAEGLFNVALPNVEDEEDGRGSHVASRSLSRSRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1U8</accession>
    <name>A0A1C1D1U8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1U8"/>
    <dbReference type="STRING" id="86049.A0A1C1D1U8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03057"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04830"/>
    <dbReference type="eggNOG" id="ENOG502S0NM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052718">
        <property type="entry name" value="NmrA-type_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129:SF1">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="305" mass="33299" checksum="7F849C5202ECBAA3" modified="2016-11-02" version="1">MLVLTGTSGNLGSRVLDTLLRQKLIPPSQLIISTSNPSKVSAAAKEAGIEIREGDFTSPDSLSSSFKGADALFLVSYPSPSVDRWLHHKAAIDAAKAAGVKTIIYSSLMFGGKTGMDSIAGVQQAHIKTVDYLTKTGLQYVVVREGIYAESWWLYAGFQPRTFKKGDTSDITFVIPNDGPVSWVTWDDLGEATAKILQNYERYLGQTLNLTGPRATSISDVAKIVEKHTGRTVKVNVVGRQEAERYHKENKSVPESNFWVIESWAGWHDGIANGETATVDPLIEALLGRAPRGIEEIADRLFTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D246</accession>
    <name>A0A1C1D246_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin synthase activator (Chs3)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D246"/>
    <dbReference type="STRING" id="86049.A0A1C1D246"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02724"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04924"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="611"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="730"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1128" mass="125492" checksum="F638B55E440F3888" modified="2016-11-02" version="1">MMAGNQYGQQWPQNQAPQYQYDGRDYQPQRQEVAHGQGSYNQGYAGYNDYPQSGNGYAPGSAPAPPRNNGNEQWQGQDQYARQGGYEEPHYETGNGSARPRRDRYDQGPPPHDRQYQYDERYRTNGQGRPPPMDHSYAEGPRPPREQWSQPSTPQKRPKPRDRILTEPASPKNLAWDNPFGAFNDLGKKKPAAKEQRHQRHASLDHAMANLNVDERPGSGGPAPRLQTPTVRRKEASRPSTSHDRPPDMGRSPPPQSYPMPAGRNSPDMQFQQQPLPRPQERIDSPRMRPSVPQGPSRGPPPPSQQPQLRQDPLHPGPGPGPGPGPAVKWPPADHNFQRSYGAHEYDQTHERLRRNHTFDEGYASDYIPQSKAHISPIDRMPPGNQYQQAPLQDYSADPYRSHPPPKPAVHNQRENNGLPNFDAIPTNVTERLEDNFIAGQKPSFDQNIYRRPTYQVPGAASGEPGQIDTRGIQQSPPNQTNSPLAEFSFDLPTTAGPTNAARNGNPAQAAMYHGGHNEHTPGQRAASSRYAERQPQEIPRSQYPPRAASRNGMKQAVENAASQPPLPNNGQPYRSFSQDTYPQRPHTSNAQRAAPQSYEVMNPYDQEFTHRAPSAPAAPVPFEQGFGPPGQNNQYQQPYGQGLPMRKASQDSYNQNQQFRQPYGQDPTIRPTPQGPYDQGLPKSSGISSAHPVPVRHYGPVPNGDTNPDALPAHPMPVRSGLSNGNSYQSAQSAPAQTPQRRAVSESPQPVTLLELNNLRQMYSSNPGDHALGLKLAKKMVEAAKVLSDENGRADAKTAQKNREKYIFDAHKLIKKLVACNYPDAMFYLADCYGQGMLGLAVDAKEAFTLYQSAAKLNHPQSAYRVAVCCELGSEEGGGTRRDPLKAMQWYKRAATLGDTPAMYKMGMILLKGLLSQQKNPREAVSWLKRAAERADVDNPHALHELGLLYESTTPPDNIVRDERYAVQLFQQAAELGYKYSQFRLGSAYEYGLIGCPIDARQSIAWYTRAAAQGEHQSELALSGWYLTGSEPLLTQSDTEAFLWARKAASSGLAKAEYAMGYFNEVGIGTAVDVEEAKRWYYRAASQNFAKARERLEELKRGGPKQQKTRMSRSNVNRQSDGECVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D297</accession>
    <name>A0A1C1D297_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
            <ecNumber evidence="4">1.1.1.399</ecNumber>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SER33</name>
        <name evidence="17" type="ORF">CLCR_02882</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="4"/>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D297"/>
    <dbReference type="STRING" id="86049.A0A1C1D297"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02882"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04895"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061759">
        <property type="term" value="F:2-oxoglutarate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000036">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="16">
        <location>
            <begin position="417"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT54800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="487" mass="53510" checksum="102B5964112D4892" modified="2016-11-02" version="1">MPTSNLTESIRIPNNGANGDQQRREVSRSLSMSTSPDHHRKVSFGVTDGQSYGTSPNLRRVATGPQPKLLKPFREQDVKILLLENVNQTGRDILQGQGYQVEFMKSSLPEDQLIEKIKDVHVIGIRSKTKLTSRVLSHAKNLIVIGCFCIGTNQVDLKYAASHGICVFNSPFSNSRSVAELVICEVIALARQLGDRSSELHAGTWNKVSNKCWEIRGKTLGIIGYGHIGSQLSVLAEAMGMDVIYYDVVNLMAMGTARQVPTLEALLKNADFVTCHVPELPETMDMIGAHELETMKSGSYLINASRGSVVDIPALIDAMRAGHIAGAALDVYPAEPAGNGDYFNNNLNPWAEDLRSLKNLILTPHIGGSTEEAQSAIGVEVAESLVRYVNEGVTTGAVNMPEVTLRSLTMDEPNHARVIFIHQNVPGVLKRVNQILGDHNVDKQMTDSRGEVAYLMADISNVREEEVAELYGELERVKERILTRILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2C6</accession>
    <name>A0A1C1D2C6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2C6"/>
    <dbReference type="STRING" id="86049.A0A1C1D2C6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03073"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05003"/>
    <dbReference type="eggNOG" id="KOG4781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31449" checksum="59B774C1B497AD5C" modified="2016-11-02" version="1">MPAPDTTPDVHGQQFAAPVHTVPPAPGAGGRSLFVRFTRSVFWAILFSSLGVVAGTALITWEYLQPPFEPGSEMERDLLDEIMDAVELHPLVDSLRQANWIEDNYYAGHADSIGTGGMHLGITMRTFKHPTQEFTMMVAFLGFGVEGWPDVIHGGIITTLIQEGIDRQIHNFYEKYGNQHAQAISVDFKRRMRPGEVYAVIVPPAQVEMNPPQPEVMHLQMMPMVVRIEAPPRITPEALTIELPSMEELHAVANVQVRLVQDVTSERMAELEAGFASQKIADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2F7</accession>
    <name>A0A1C1D2F7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2F7"/>
    <dbReference type="STRING" id="86049.A0A1C1D2F7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03210"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05005"/>
    <dbReference type="eggNOG" id="ENOG502S3RW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="96" mass="10525" checksum="317BE26F7D6C831D" modified="2016-11-02" version="1">MTQALALGLGSMFNHSTRDQNVGWIRNTETEVIVYTTLRDIKAGEELCISYGSARLWFPDADAQANASERPEDDNDDTGGETLAELDLSGLSKMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2T4</accession>
    <name>A0A1C1D2T4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">dbp8</name>
        <name evidence="17" type="ORF">CLCR_00013</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000001">
        <property type="protein sequence ID" value="OCT55119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2T4"/>
    <dbReference type="STRING" id="86049.A0A1C1D2T4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00013"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00004"/>
    <dbReference type="eggNOG" id="KOG0340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="111"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="331"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT55119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="532" mass="58180" checksum="ECFC26D78B3229BE" modified="2016-11-02" version="1">MAPSRLVDEDELGSRSDNYSEGLSGDGAFSYPSPKRRRISTEQDNATVPQTSLSRVKKIDHASKIVRTPAAHPEIPMTSATFKSLNVAPWLVQSLAAMAIQNPTEIQKACIPEILKGRDCIGGSRTGTGKTVAFAVPILQKWAEDPFGIYAVVLTPTRELALQIFEQFQALGAPQNLKTVLITGGSDMRPQALALGKRPHIVVATPGRLADHILNSGKETTIGLSRTKVVVLDEADRLLASGHGSMLPDLSTCLGALPPSSSRLTLLFTATVTPEVRALKDLPRPKERPPIFISETTDLSDGALQASLIPATLSQTYLQIPMTHKDAFLHVLLQVPSFTKSPEPSIMIFVNRTKTADLLHRTLLQLDHPVTALHSELAQSQRNRNLSDFRSQRARILIATDVASRGLDIPEVNLVINFDVPRNPTDYVHRVGRTARAGRQGTSITFVGQRDVELILAIEAYVGSKLVEWTEEGVNVETRVLKGRTLKDVAEAKMEALRDVESGKDVNGWRRKLKKDKKRLLVEASSAPGLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2U7</accession>
    <name>A0A1C1D2U7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_00020</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000001">
        <property type="protein sequence ID" value="OCT55129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2U7"/>
    <dbReference type="STRING" id="86049.A0A1C1D2U7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00020"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00014"/>
    <dbReference type="eggNOG" id="ENOG502QQJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="44"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT55129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="409" mass="46949" checksum="DB215C0262E91261" modified="2016-11-02" version="1">MGSIDEGCASGGGHGPTVNTLPASWYREEGLYELEKRAIFSKRWMCVSHALRFKEVGEFVNFEIAGFKFFVIRDRQKELKAFLNVCRHRAYPISEKGSGEGGKVSILACKYHGWSYGLSGNLAKAPRFETVDNFDRTMYSLYPVHLRLDRLGFVWVNLDSANPPTIPWEDHFDGVDMQSRQKDFSMDDFEFDHAWELEGEYNWKAMVDNYNECYHCTTAHPGILATTKLDTYDVKGINGFIEHYSEPLESVEHKYGVQPTYFFPNAAILISDGITYLTRFAPKSATSLKLEYEVYRHKDCTQEDFDTMNPFFKQVEIEDVALCNAVQQNFNTDTYINGPLHPHNEKGVIYFKNLVKDVLYKHMAEEQKAGQKIFPARRTNDKDDEIAEEEAFCRLACDGNSGPKAIPQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C668</accession>
    <name>A0A1C1C668_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C668"/>
    <dbReference type="STRING" id="86049.A0A1C1C668"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00081"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02034"/>
    <dbReference type="eggNOG" id="KOG1230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF441">
        <property type="entry name" value="KELCH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="663"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="804" mass="84807" checksum="20874D871E8CFA8E" modified="2016-11-02" version="1">MPTTDSLYSDRGYSTAATPTADLTHPHRRSPVESDSLRGSGDPDLCNGAPPRRNSAFLEVGLGGDDAIIDSKLKRDPRPKSQIHISRKVDIDEAETVESSPTSPVENLPRPQMSSYFPTLPRLLFLALVIVVVAPSLRSSPLLTAKANPLGRDTRSSGSIESLQEVKREALPQKSKREDTQTDVCKRWAGQSAIVNGTLYYYGGRVTTSPDQTTDQWNLTKSWQISSPSLTGLPIPSGPPAVSLGYLWSSYDALYLYGGEFSDTPVASPVPFSTWIYDISSSSWSESSDPQTSSGKNSEPANQPVQRAAEGAGVSVPSLGRGFYFGGHLDFLTTPGWSVSVARVYLRGLLEYTFPGYSNSAVNGGKAAGSSGIYRNITDGGTQDSAGFPERADGLLVHVPGFGKSGIILGLAGGTNSTFTQMNVIDVYDIDSSTWYKQATSGPTPDIRVNPCAVAVSAADGSSTQVYMYGGQNLLPYGEQKQYDDMWILTIPAFTWIEVDTANQANPPGRAGHMCHVWNAQMVVVGGYVGQDLSCDSPGVYVFNTSSLEWQSSYAALKTDDDLNRQKSQQDDPLALQGSFGYSVPDKVQSVIGGNGVGAATVTAPAQAATQGPLATGGPITYTVTQSDGSVATETATPTGTDGSAPSVQPGNQDSGSSGGSNVGAIVAGVIAGLLAVVAAYLGFCVWLYRKQLAVYKNHVAMAQNQHLTGDPRFIGVGAAASRPYTDKSQPSSDGSRYSADNRSGSSGGRANQLSSNNPYRNVPGGTGAATAASSTEDLMAGQEPSFLGVVLNPRRSLRVVNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6C9</accession>
    <name>A0A1C1C6C9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transporter mfs2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_00089</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6C9"/>
    <dbReference type="STRING" id="86049.A0A1C1C6C9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00089"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02035"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3365399at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF12">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="109"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="541"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="622" mass="68646" checksum="ECE35779CD5D460B" modified="2016-11-02" version="1">MSDPEKAIPPVVISQWPTSPGSSPQTPTHKESWSPTDTSPTSSRSDSDNDERALTLTITQASRQSATRTATRITTHGTDFTLDPNYEVDFDPDDPEDARNWSIWYKAYAIFSISFGTLCVVMYSTSYTAGMAAMMLEFGITSEPVATLGVTAYLLGLAVGSLLLAPIAETYGRKPVYTICQAGFTILILPAALAKDLPSVIVVRFFGAVFGSAMIANAPGSIADLVSDEYRATAFSIWSIGPMNGPVVGPTIGGFVTEYMGWRWTNWVVMIWGGVSCILLIFLGETYAPVLLQRKAKKLRKENDDERYWSRYDIRVGFWELMRINLKRPFVMALTEPICMFWNVYISICYVGRAGILYLCFVAYPIVFTEYRGWSTGISGLSFLGIGIGTMIIICSASPIRKMINSHKRDADGNVPPEAMMSIVCIAAILVPVGEIWFAWTCYPTSIHWAISIAAGIPFGFGNGAVFIYAGNYLAYSYGIYAASAMAGNAVMRSFLGGTLPLAGPSMYRALGPNWAGTLLGILEILIIPIPFLFYRYGGRIREKSTLIRQMREEEERQERKRKKAEERLRIAVMNGDETETAQARTELVRVRSRIDDERSVEVAGQETLNNIQGLGPGKETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6T0</accession>
    <name>A0A1C1C6T0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6T0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00741"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="104" mass="11241" checksum="0D92FE2F1EA601EF" modified="2016-11-02" version="1">MAASFTLVGDQQETTPDTTGRDNKRINEENHARSRLAPSWVGLFAMAEAQLGGLGDDVVLVEFDAVVDVNSDADARGGCRRQRQAGPPVEKVSSQRPNASRLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7A0</accession>
    <name>A0A1C1C7A0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Meiotic recombination protein DMC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7A0"/>
    <dbReference type="STRING" id="86049.A0A1C1C7A0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06229"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07039"/>
    <dbReference type="eggNOG" id="ENOG502QZN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031349">
        <property type="entry name" value="Tfb6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781:SF1">
        <property type="entry name" value="ADR380WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781">
        <property type="entry name" value="TFIIH COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17110">
        <property type="entry name" value="TFB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28680" checksum="FC200DF9BE80D30A" modified="2016-11-02" version="1">MAYSHPQTLPTPPASAASPTPSNWSTSSRVSSLPTPRTHRLQPGSQKEIALIIYLDNHILKITRRYAKKFSDEGLQNDDTPGYTTYDQFVADVDPLVDVVWISGTPSIQIPYLLQLAGLACSYLQAFPFSTSVFPLVSKIDQGFASLLQPTQNGGISSTHPQVSVTEKVRIKSLIEETRIAAVNAASSSGHAASVLDITDTDTDDDDNQREEVEQGDEDDEDEQSMSVALALSRIYKRTLEILGDSLITSVSPQPQDDDIPMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C852</accession>
    <name>A0A1C1C852_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C852"/>
    <dbReference type="STRING" id="86049.A0A1C1C852"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06241"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07360"/>
    <dbReference type="eggNOG" id="ENOG502SP9C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5342507at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="27678" checksum="81B35E6EAF4886A3" modified="2016-11-02" version="1">MAFGGAVLRFGQTGLRLLEFASSAIILGIYSYFLAVLAQKDIHIPTWEKAVEGMSGAAVLYTIFGVLFTLFLGGITFFALIAIILDLCFVGCFAAIAYYTRHGANSCRGIVNTPLGFGPDSEAAPGAGDWGYVCSLNTAAFAMAVLNIFLFLITAIVQVLLARHHKKEKRFGPSPKNNYTKGTGRGPFWRRNKKVRTTRDAEMATGTGAGAGYRPSHETGMTGSTMHGGHAPFSTEPKYGQPGYGQNVPYNHQATNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8B9</accession>
    <name>A0A1C1C8B9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8B9"/>
    <dbReference type="STRING" id="86049.A0A1C1C8B9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05988"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07451"/>
    <dbReference type="eggNOG" id="ENOG502S4MP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3886346at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="390" mass="42538" checksum="42801DEBFBCFF210" modified="2016-11-02" version="1">MAQAMDAHSSFVYLVDNLPKWRTTLDSLATHTAEKHAEFVAEYARLLKQARPKRKKTPSISSIHSTEEQASIDDQASGEENVDNTSSHGPIEINPLEAGTRYLFAQARRKRKPGTSIRSGASGPQKFRNRNHVVVYYDSYLQKQLDAMVKEVGLGRNNLRKGKNALAAATGFQLPSLATLSGNGGLASSAFDDFRPPNMSRSTSALLSVKKSVTLSPQPPSNQASFIQADKELEQIQSLCETAAHQFLRDGDCKSELDTIRGRLDALLVQATRAAASLKKLQEEQEAVHADSSASESHHETESRGTLSTQPSFDLLPPQKIAVAKTLHPPAISHPLDGLKPQGFLSAPAVSTLGHELANDTIEVDDSSDQESIVVDLSQYRLTNPRRIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8C0</accession>
    <name>A0A1C1C8C0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase bleomycin resistance protein dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8C0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06379"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07379"/>
    <dbReference type="eggNOG" id="ENOG502S96F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447346at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07247">
        <property type="entry name" value="SgaA_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052164">
        <property type="entry name" value="Anthracycline_SecMetBiosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993">
        <property type="entry name" value="GLYOXALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="10"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="139" mass="15280" checksum="CB232314784FB493" modified="2016-11-02" version="1">MAETPNPYGQICWFEVLVTDVARASAFYAKVLGWDCNDLEGTPSPSGRERSVHMFSKGTLHGAFLLTRDEDGVAKFDDLHKKAAPIVTFMVDSIEQTTKKIEDAGGRVNLPKTEIGGGMGFFARFIDTEGNLHGIWAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8J8</accession>
    <name>A0A1C1C8J8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha-1,2-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_05731</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8J8"/>
    <dbReference type="STRING" id="86049.A0A1C1C8J8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05731"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07454"/>
    <dbReference type="eggNOG" id="ENOG502QQ16">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4484309at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT44778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="557" mass="63153" checksum="65E0C4476E102639" modified="2016-11-02" version="1">MILHPRRMGGPWRRKSSLITSLLAFFLILLFIQTRIHYRPAQPEPPSIPHPEPVAEPQPAPSPVPKTEPSLKVTHPLLKSQAKFWRSLYQIILNNDPNCKNAPEPVVPQKLDVGFDPTQNRPRPDVLYMDTADIKRMREAHSNFVSDMKDVAPVPYNPGTRGIALTGGFNQLPVLVISVRMLRRTGSDLPVEVFVTDESDWDDEICGMVLPSLNATCLLFSDIFHAANTGVAIDRFQFKIMAVLFSSFEEVLLLDSDAFPVHDPLPLFDEEPFTSHGLIVWPDFWYPSESPYYFEIAKIASVPPLNERASVESGEVMYSKSKHRMSLMLAAYYNYYGPSYYYPLLSQGAPGEGDKETFAWAAAALKEPYYAVHERVMALGRHDTNGHYLGTAMAQHDPVADYAFTKAYGPPHERNKDGDSGKENHFDIQESDVKPFFIHANFPKFDPATIFDHKVTSFADQVVGQPTRDTNGTNVRCWMDPARAIDLFGFDIERRFWEEIKATACENEQQFRTWKAKTGICRRTQEYWDDIFAVNATATPLEDHQHIQSSIETPSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8M7</accession>
    <name>A0A1C1C8M7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8M7"/>
    <dbReference type="STRING" id="86049.A0A1C1C8M7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05362"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07475"/>
    <dbReference type="eggNOG" id="ENOG502RY1C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310870at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="959"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="961"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1283"/>
            <end position="1298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1298" mass="138904" checksum="BDF0FB0B4E2C12F8" modified="2016-11-02" version="1">MAEKSTQDVVNQSQSVGDVSPSDAPATTSTPDIKVSGDDTSNSAVEADVAPKENGNHPTTSTIKMEDLDDASARSDTDTSRAEGSVAGDKTADSKPLKKFAAKPVSFAKYSVPKVIAASAAAKATDKAPTPSSTTPSLAQAGRPRLVAKTTSTLQSKSKPYQSATPDPMQVWNKNRVTPQPSTKHLTDEELKQQYGIHLTSRIQADGDGKEAKWADIDDDEDDWAPETIEWNDGTKSTLTPAEAAPQIATKPATPPTDKPKPATPVKTPAPQFAPSIGPNATVLKLGASAERQQAQKAATLQAKAPAEKPSITTKASPAPAPAKSPWAALPPVDKVSPIAITPQPVPLSARFPAGRGYTEGPTAQQAQSPAKEISADDFNRGWRDSLPNQPRELYMPNSGRYEAVPEGRRRMSKNDQNFRAPAVLQRPSPMDPHAPAEPSPAFQTHRTSTDQARRRASSTISGGSGQFGRRMSLKSSDVHSPSLDTHRHDIDTAVRPASRDGPISATQTPTYQPRGMSDYVSSGAASATDADLEAQRAQQKALMKENIERARRRKVEEEQQREAAKQERIRLKLASLGPDPRLTKKPEEETQQNATGENEEEATAQPPVSAAPVAPLTSAVSTTSTSTHSPPKPPQPLASGEPQQYGMMKVHPLDSVKKMGTSMTRAVEPQRLPARDRNEAGATEQPHVETLQVSSPVVNGGRIVPEVRRTSEQETVAVPEPSPKLPKSSTVVNDTRGGWGEMRHHDHRSQQTSSLWGMPNKALGNGTFDQSLAGYSPQDLSRTSSTAAGWMNGRTPHSGRSPQIPHANHAMVDNRSYSFQSVTSPDQGPLAADSEVDSLFPTTKPAPIAPPQAQQAHPGMTGLPSGPRPNGVQSWNNFHSVASQQERAENERLQREEIARREEEMRTGVRQGPSYMFNETWKQVQTGDQAQRSISGVSQSQVPASGAFGAVGSLASADAGPRGMNGPPGRGSRFFPQPIGQQYPLHDRRAVTYSHPEPPRTPSPPPAEDYASLHPAFDGDFKKPIVHFPHKPVVRLPPAMPPTPPSPLHVEPALASATGPAPAAPLTWAARVSMPAPPPPAPLRTVSTPIIQNPSWQERFNGLLGKKTSPAQTTAEPVAAVLAVTSATKEPLDVQHVLVPAASVSLPVEVGTGSLGNDTSVISKDVESEDDLFEDREPGSLPTIKFPLETSQISMARYFPSRLVASAPETTSVFPFMVANWFEPRRQPGRELYALIKMPGAAKSVRKELPAKGSPMPHNGGRQRFGSGPPSSSGSFGSNKNFRGKAGLRSRQASKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8Q7</accession>
    <name>A0A1C1C8Q7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8Q7"/>
    <dbReference type="STRING" id="86049.A0A1C1C8Q7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05610"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03611"/>
    <dbReference type="OrthoDB" id="4154081at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470">
        <property type="entry name" value="VAST DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="126"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="634" mass="70054" checksum="98B190F4C046A929" modified="2016-11-02" version="1">MSATSGISAVSSNSDLPPSSYDGSHLPWKTFRQHVLGAHRIRVVDAPPKEKLPAVLLAMIETELSNTAKYEHQKKQFHDQVDKGRGFGPSPLFPPNLLPPIEDEHRLARCMVPSFSREALPERALNQMSPLYELSIPRSGLGCGFSASAFANEELGVLPSWLVCTGTVVHFDTGYISPGAALYCPFLVFERAWGDKEHGLEAANNQCAIGGAWCVRALQMLYAQAWKGQMMPELPVAFSCSIDNTVAVLNMHWIDHGQAYCMAPLCKFDLSKDDHFSKFLVWIDSIGKWGLTHLLPLVKTALERLRTKDDTPPQTPRATKLTLDTGICPNEQLIKSLKNTFENIPWRFEDDEFTPVSSSTASWGSPMVTDLTFSNMSYPTMPSRAVGSTPTSTIQRRNYLTQLGQHPTPPPAYAQTPDLVWQKRFNHAMDEIRDLQRQIQSLKTDFSGSSTSLQTELSAVKTTMNSVLRKESFTARNRSLSLNMQETWATQGIPRSPLINEVLPDFRITLLSREKSHRGEASPNLLSPGLQLRGPLSPGMPSPGLSSPGMPSPTFSVYSETTNIVNVPPAPPAPASLFKFASLMVSGHMVSMFIPNVILRVFVLGCITDVCMLAFASPHLPSSAEYLLSLWRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8Y0</accession>
    <name>A0A1C1C8Y0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8Y0"/>
    <dbReference type="STRING" id="86049.A0A1C1C8Y0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05635"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07642"/>
    <dbReference type="eggNOG" id="ENOG502RZ8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5376804at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="639" mass="70883" checksum="4E128DDCF87BDBD3" modified="2016-11-02" version="1">MDNYMIKTEQDAYRRESKRTGVQITEHTESDQERDGCSHEDDPTTPSAISRLEQLMERLWAFEIFALVISTLALLGLIILLRVTNGQKVPNWTVRPKHTKPFTVTINSVISIFSTAVKSTVLIPVAAAMGELKWMWFNSGHRLTDIQVFESAARGPLGAAIMLWSFRGRSLACLGAVIILGSLALDFGFQQLVTYPLRPVNLGPATIARTNEYFAYRPGWITGTPLAEQPMVAAIYTGMYGDGKSFPVTPGCSTGNCTWIEDYTSLGFCSRCYSTTDQIVKQCGTFNYTTFDENGEPLVVGDPIPYCNYTMPSGQFIAGVNLTQGYVDPVFVDIDDSPASDKTYFGKPLTANVATLSVMRAEWQSVADDQGRYYDKIIAANATECGIDACVIKYHATLEKSNFTEMIIDTFINETDRQVFSEGDGGYTMPVYIHPPQSWTNHSNVNDSNIYSLDSVTIQALRFQFNQNANQPLWGGRFIDSMRGQVSVDNDFVAYVRYLDEAGMEDMMSSLTSSMTQRIRTAPGAGTNSYGPGPNTIGITTQHMPHVNVRWGWIALPAAILLLSALLLVCTMIESKRQGATMLWKSNALAHFYHPLTKEGRNRLRDAHSAKHAEKIAQDMTVKWQVTDEGGRFVPINGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C949</accession>
    <name>A0A1C1C949_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asa1</name>
        <name evidence="9" type="ORF">CLCR_05906</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ASTRA chromatin remodeling machinery complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C949"/>
    <dbReference type="STRING" id="86049.A0A1C1C949"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05906"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07736"/>
    <dbReference type="eggNOG" id="KOG0322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT45063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="425" mass="46593" checksum="E6093FEF6CA3D7E4" modified="2016-11-02" version="1">MEQGPTVPAYILRGHEAPVHALHFYADNSFLASGDSDGWMVLWSLSSKRPVAVWKAHEAGILQIQHWTKDRLISMATKRHHDGRHSHGRDHKLRVWQVRPETLASLSRKLPAEETISTSDLPHPWLLHSLSVSALNFCAFSMCNEDTAGEAAGEAPPQLIASPNGLDSGGIDIFQLPSEKRVSQIGSDKNDPTGMVMAVSLWHQRDEPSSRLVLAAGYEDGRVTVHVHQGDLDGSTQAIGQTWKKVLIAKPHIQPVLSVKILPSQSQFLTSSADASIAKFSVPTLSETAVHETRPEKAVNTKHAGQQGLSIRSDGRVFATAGWDGRVRVYSYRTMKELAVLKWHKVGVYSTAFADVSSEDDVDVSNGSEELTSSPNTTPPTPAPGISRPMSALDLIKQKREDKARRIHWLAAGGKDGKISLWDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA99</accession>
    <name>A0A1C1CA99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative tubulin-specific chaperone D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_05375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA99"/>
    <dbReference type="STRING" id="86049.A0A1C1CA99"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05375"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08029"/>
    <dbReference type="eggNOG" id="KOG1943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253476at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="352"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="4">
        <location>
            <begin position="437"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="4">
        <location>
            <begin position="520"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="3">
        <location>
            <begin position="931"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT45398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1195" mass="131200" checksum="A4E4EF45DF70C475" modified="2016-11-02" version="1">MDASELDLDAKLYKASGTLLAELQHKLPLLLYRGGRAPRKCVLITKSTELSLLLDRFQEWPQLLDPCLANLVQLLTDTFLGYLTTSKDQYGPTRSRGTAGVSPLPRAICSLLYSLCKVRGYKVIVRLLNNEPKYLKLMLSTFRAWDVPGAGMTWEERYIMLLWLSHLLLAPFELATISVQDGRIRDAAVPGELGGLPGIAGQVISLALQHLGGAGKEREAASILLVRLSWRTDMQANGLSTRLVHYTSRELLSSSDMATLTPYQALGFLSLLYGITNSGSDSGVAPYLQALFDSTMKIALDQRNQFASIRDSAPARKWVLKILRAILTHALSLSLRNGANQPHQLNAMLEESIQYFLDALGDNDTPVRMAAAKALSVIALKLDPAMSAEVVEAVLGCLEENVLLEDTHTQRLVAITDTARADTTGMRRNISAVDPLRWHGLMLTLAHLLFRRSPPPDMLSEILQALILGLEFEQRSNVGTSLGVGVRDAACFGLWALARKYSTAELDMVSVASFPEVSRYEYSDCKSVLQLIAIKLVVSACFDPSGNIRRGASAALQELIGRHPDTIAHGIPVVQILDYHAVARLSRAMTEVAPQAAGLDVVYHGPLLQALTEWRGARAADVNQRRWAASALRILTKTSPLSKTSTFAEAILKRLSDLKAMNIGSTAAARHGLLLALSSILQSMRKGDTQFVTSWLGGDGRLTLDLKKLTGKIEGRTTADVELVMEGVGALVCEICKCSDSAGPPWVSIQGWTATAVEVLNHCTVVGTKDIVVRSSAEAFVELFKVLPPEAGMELIERWLDSKQQPPSAFASKGRMKVLSLIHGHPSARLASNETRKKILKYIIGIIEGVYKIETRVDAMEALGVILTNDFSEHAEVSVALSSVLQRGLTDYTNDQRGDIGSILRLQTLETVDAYRGNCSAHGENAAVLRQVMPLVVKLAAEKLNNVRFRAWKCLENYLQTDSSLPAIQGAFQFPADVSSAAYFQQLMRLLSVPWAHRHLILGFISSATSGSEDTCRAASTAFVSYMQSLEPLQVEGSIARVSAMILEELALRATEDDRQVLPFLDFLCFMIDEELFSTKLFGQSDNVDLGMWSSMQRLHSPSSTMQRMESLMNVYSRLLSIDIYRARALDKLTRQLLHRWPKVRNTAADLLYLDSPVETLASSDWNAPVAKNKAVVLSLRKQLGVVSRPDANGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAI5</accession>
    <name>A0A1C1CAI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAI5"/>
    <dbReference type="STRING" id="86049.A0A1C1CAI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01415"/>
    <dbReference type="OrthoDB" id="74545at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="906" mass="103088" checksum="420581E163BA3AD6" modified="2016-11-02" version="1">MASSALPETLRSVTSTKIQELKKQRDQYEASKKQIIREVKPCTDDLERTRKLLEGSCRQAGLRVVKDDSSDEDVDPTPSSDLAGARRNQQLFLRQAAKDPAFASDLVAQIHDDLVEHLNLKSVQHEHAQFFSELVTEWLSDPRDAETGLSGGGVAEHSSFESVGRKEMHEQRAQWESIVFSVSNEDEATIHDYLARLFKAPGATQKHFEDIKKSTRDFCTTLRSTDELFDTDGLKTAINGLLLSDLLSHEKAAILRSFQNNSAVLQEVADVLNMRFASLETWKWSTVNGAIPVEQWRQLNGKYRVFMDEDILDALLLHTIGMKWALHFRSCLTEFFESPAWRSAGGSVPQTDKDRRRWFLGEESNPSTAVETKRKELYAHDYFMSQLPISESEGTRGYESDDNTSSTRKSPVETKQGLLHLLITEALVARHLRPTVPHAVIRSDFEWFGPSLSHGTIFAVLKFFGVDATWLAFFREFLEAPLRFVQDGSKGQIQVRQRGVPMSHALSDVFGEVILFVMDFAVNTATQSYLYRLHDDFWFWGTEDLCARGWEAMTRYASVMGIRFNQEKTGSIVFGQGIPTQTSGPTPDASIEKGDETTPSRPANLPKGDVRWGFLRLDATKIQFVIDQGMVDEHIKELRRQLSHCTSIFSYVQAYNAYLARFFSNNFGKPSYAFGRDHIDDMISTFARIQNALFVDESVTDYLGKIANQRFGVNDIPDGVWYWPVQMGGLELRNPMVVLYCMRETMRQSPHKILSKCLDAEEKSYLSAKARFDSDIRTYGRKRSWPSSSPGFGENFMSRDEYLLHREERSVNLYNAYVRLLDIPTEFEIHETKEITSWLNKLPDSRSSSAGFRRSFGTMKPYWKWILAVYGAQIVEKYGSVQIVDAAQVPLGVISVMKAGKIRWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAU4</accession>
    <name>A0A1C1CAU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01673"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03498"/>
    <dbReference type="eggNOG" id="ENOG502S6DB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF9">
        <property type="entry name" value="POLYKETIDE TRANSFERASE AF380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="274" mass="29464" checksum="18994E32A91E276F" modified="2016-11-02" version="1">MDPGRAGAPEHAAGFEALKQAQKTVGTVERLNIPVGGTTVRGFLHLPAGYTENEDRVAAAALLLSGAGGGVSGPSGMYVSMGDKLSSLQRGIPVLRLDYRYPADNNPCVEDVTSAMDYLDGKYSICKYVLVGWSFGGAPVFTVGGQEKDRVVGCATVASQTAATKGIRYLAPRPVLLLHGTGDRTLNWHCSQSLYEVYGKNGDRTLKLFEGDDHALTRNSHEAEELLCAFIARCLDVEISGRERESVLQKTLTRDGDKVDLMKKGGDLEGERIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBD1</accession>
    <name>A0A1C1CBD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DCW1</name>
        <name evidence="13" type="ORF">CLCR_01565</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBD1"/>
    <dbReference type="STRING" id="86049.A0A1C1CBD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01565"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03679"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT45787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="445" mass="48351" checksum="CDFBF2302B289D55" modified="2016-11-02" version="1">MAQGLELDLNSMDSVKSVTSTLAYDMMTYYSGNQSGQVPGLLPGPCDNVACYYWWEAGAMFGALIHYWQYTGDESYNHVVTEALQFQIGPDQNFNPPNQSKNMGVDDQDFWAFSAMDAAEANLPDVGGDAPSWLALAQAVFNFQTTLWDPATCNGGMRWQVYSFNAGYNLKNTISNGGYFQLAARLARYTGNQTYADWAIKMWDWMEASPLFQVQDGTLFIWDNTDANNNCTDVQHFAWTYNYGTMLMGAAAMYNFTGGAEPWGSRVNEILDGAFNLFFPAEYGGNIMSEFQCESTMVCNNDQSSFKAYLSRWMAVTAMIVPETYDTIMPKLRDSAVGAAQQCTGGDNGRMCGRQWYASFDGSSGVGQQMQALAVIGATTVNPSIAPKTANTGGTSESDPDAGTDANASPTIEHSPITTADKAGAAILTLLCAGVIVGGSVWLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBQ7</accession>
    <name>A0A1C1CBQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBQ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CBQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00478"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10054"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="357" mass="39710" checksum="0D9EC066FA66E601" modified="2016-11-02" version="1">MVHYIRFLRTPRCDASKKTVDVSAVVAVQTDLSDALLSQDLVLNAEIVEANSPWRVLHSQSLQWQATSRALKFTIPCPGKYTSWPVRLHLAAQETQSALNLAEIPEVLDIWSCDFLLSDKQRSEPIVERRLSLRNNTTVRIWEDVGESMARHIWDASLGFVMYLARALSSSPPSGVATLAALVKSSKVRKLQVLELGAGCGIVGISFAQLVKCDMYLTDLEDAQAVLAKNIRCASLLAGSTLQADVLDWASGLEDSSNPNFDLILVSDCIYNPDSSVHLVEILRQLAACAPNTLIVVGFKRRHEADAVFFEHMRKTKFEIVESTQIPLPHRPTAYDADTPTTEFYLYRHQGCSDPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBU2</accession>
    <name>A0A1C1CBU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC a-pheromone efflux pump AtrD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_00353</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBU2"/>
    <dbReference type="STRING" id="86049.A0A1C1CBU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00353"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10066"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001471">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF15">
        <property type="entry name" value="ALPHA-FACTOR-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="815"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="856"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="933"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1036"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1074"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="42"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="373"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="816"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1140"/>
            <end position="1407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT45939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1412" mass="154546" checksum="D60F462D8552DBA2" modified="2016-11-02" version="1">MTTDAHDEDPKDSAQTNKRYGMFNGWRSLFSFTEKSHLPVLLAAIFMSTAAGSLQPIMAFFFGKFFDNFTDFATSNIDGATFMNRSLTSFYALFAVGGATFLFKGALFSLWLVFGELQSRCVRELLFASLLDRDMDWYEARTSGVGTLLTKIQRQIRDLQLGTSQPLGMTIVCLVQALAGLGLALRTNWKLALVVLAAIPVIAIGAAVTSRGLQANIDGHNEELATTSKIASNCIKNIVTVKCFNTQEEEAGSYTAAIKRAAAFALKQAFSSALQASYSVAISSIGSFWHTGFWYGGAQVHSSQTTAGEVLTTFWACLIATKAFEDMLPHGIIIQKSQASATALQAILNKVGQGKLQSRKVAGLSPQFCEGNIEMREVSFAYPSTPSKLALDHCTFYFTAGETTFIVGKSGSGKSTLGNLLMAFYRPQSGSIIIDGNAIQDIDTRWLRNNITLVQQHSVLFSDTIYRNITLGSRDYERVTSAQVDKGIRMAALDSTIAALPDGTQTRVGTGGSSLSGGQKQRVALARARLRDTPILIFDEATSALDNTSKVCVMASIREWRRGRTTIIITHDLSQIGKEDFVYVLQGGRVVQEGRRKSLVNFPSGATDHKVGLTEFKAQRLAGSAHTYGPSAEALYADRAQGPSPRHVREDSFDVLMKGTHGGLLIDSLQDDTHSTQTPHQSRNGVSLNGIGAINFLKRQSMARAKIMYALHHRPSNEAQSTAGDPVMRTLRYAAVAARKSLYLPRIPRTPLSRDRPLPIPPPQYEMLQGDRSLEDNVLEFPTEQIEGHPQSPSSIRAVLSTLWTSLDKPDRSKLLFGFLATLCHAGAPPAFSYALVQVFNTYYMPTGYQREALKWSMVVIGIAVGDGVACFFMQYLLDSVSQAWVDTLRTQALGRILRQPKGWFDEEQNNPTVLVSCLDRNAEEVKDLVERFAAQILVVAVMMVVAAIWALLNCWKITLVSLAMSPVLYVLTKGFEVVSARWESRTNSAGEAVNQVFADAFSDIKTVRSLTLESYFHIKFRNATTTGFSVGIRRAIYTGFFFGLSDSAIAFFTPMIFWYGAYLAKEGEWPVKSILTVYGLLLFCTANANAVIAFIPQTTSAVDTASRLLRLAHLPVQSHEEIGQVQLDRNDRATLSGPIHFINLTFRYPARPRVPALWRLNLTIPAGQITAIVGASGSGKSTITSLLLGLYSPNVGDHRNGTTWNDTSDDPPSLTLSGRDIRTLDLRTLRALIALVPQTPVILPTTVRENIIYGLSYNRLSTSASASASSIETVARAAGIHDFIVSLPQGYATVIGDGGLDVSGGQAQRIVIARALIRHPKILILDEATSALDHESAEFIRQSILRLVREGRRKGKPLTVIVVTHAREMMEFADNVVVMDQGTVVEQGVFDELMTLEGRGRLWGMLHAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCE3</accession>
    <name>A0A1C1CCE3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01324"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="199" mass="21165" checksum="3DFBF4D0B9D64B25" modified="2016-11-02" version="1">MSPGDSMSESVIAPVWSGEAFLACLLACSVPRKGARATPFNNNIGVLLYLYRPYPTTNSTAPPPTVARELKSATRVTRTRRRGTHTPIPPVPLCRGTDTPGPPSADPLGHIELELTDPAEEAPKRTSEVRAHVLLEQADGKGIKGFNVLIKGLAWEVGVPLEDVDDDGPPGDDVALLRFFVKEDEGADDVGAETICATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDR9</accession>
    <name>A0A1C1CDR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02148"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="155" mass="18049" checksum="948059EA388E7274" modified="2016-11-02" version="1">MGNTQSGYSEIRRGNGFYQSGWRSGGDHPRHIRSDAGYTFVRHGPPYGRRSYDPYHPSRRRYDDMFDRDDGNSRRRGRHGRSSAHVPPRAPMPPNWNDREYAGGYDPFYSGRRPDRRHYRTEFSFFPDLPPCAPRGVVLNPHERYGPFMSGGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEA6</accession>
    <name>A0A1C1CEA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEA6"/>
    <dbReference type="STRING" id="86049.A0A1C1CEA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02029"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01517"/>
    <dbReference type="eggNOG" id="ENOG502SVDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4130940at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="315" mass="35625" checksum="71B40FE6CDB2149D" modified="2016-11-02" version="1">MSLASFLQYNPQYPTHGLSSFKDGSAHAFPGSDTQTDRPQATQMDGRRGLFGSSRFNTVFLLLFRLFYHASSFEVASIGHASKLYLPAPVPLLQESVIKAGASGGVSSEGVMVGSANRGLPGIFKNFKRFSTREWLATMLENPDQFKNLKVNSITWIKALASPFSHEFTQFIVEDSVSGQKTRVAAGREENGDWVLVGWDWASGDTPSDHYNLPLPLLSVTFDDPSTKPDLGTLAHVLASTTEKHPAYKFRREMCWWYAETVLEVMHEQFGGKVKEWEWSRYRYSFIVKTSFIRRKALTKHAELFRRQLAEEMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEC5</accession>
    <name>A0A1C1CEC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEC5"/>
    <dbReference type="STRING" id="86049.A0A1C1CEC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11255"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01520"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23731">
        <property type="entry name" value="ARM_ECM29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="176" mass="19264" checksum="CDE16D99D8DE3FE1" modified="2016-11-02" version="1">MFKILSTHPTSSAEVLDLSTRIVKHAQGARSNAVDVALYESAKFFVANGPTTKGVDVGADRSRDQNTAGASDGVDGGALATAPPFRTGETSEVGGRREFEPFQPLVMAVFAWPKEPWRQPERTRKSRVDLALAFVQRGMQAPATLAAILDPWLVEERSRPLREDIQRACQACKRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEE6</accession>
    <name>A0A1C1CEE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEE6"/>
    <dbReference type="STRING" id="86049.A0A1C1CEE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02042"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01540"/>
    <dbReference type="eggNOG" id="ENOG502RXTJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="674948at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129:SF2">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="324" mass="36030" checksum="9321D70FD489237A" modified="2016-11-02" version="1">MSLSSGAASIHAPSHGTVTLLILGAGWTYQFLQPLLERELCITYAATTSTGHDNTLEFRFDPESDDLEPFQRLPLAEYVLITFPLKGKGPSKKLVGMYEATHARSLSREAGYGVEKTTQTKWIQLGSTGVYTAADWVDCSTPIDSSNERGIAEDELIALNGCVLNLAGLYGAQRQPGNWIPRVAKTQEQLGDKGALHLVHGVDVGRAIIAVVKEDQRSSSASEPDASLVFGRRWIISDCVSYDWWQIVWDFNGESEEAVFSEEEDAENAAEADTKRKYRGWVMDLMDKKGVRGLPRPPELLGRKLDGREFWTSLRLRPERALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CES6</accession>
    <name>A0A1C1CES6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative MFS-type transporter YdeR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_02511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CES6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02511"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02462"/>
    <dbReference type="eggNOG" id="ENOG502QUXC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2105912at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17324">
        <property type="entry name" value="MFS_NepI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="359" mass="39331" checksum="4C4ED7008E32ACF4" modified="2016-11-02" version="1">MAPPHRRSTSLSIVVSGMLLGMLIARLLSGVVARFIGWRYIYWISFGLQYFILILLYLFMPDYPATNPGEKIWRRYPTLLWDILKLVAKYPVLVQAMLIGLLTSTSFTSYWTTLTFLLAGPPYHYSSLVIGLFALIGIGSMTWGPVFARTVMEKHQPLFSVIIGELICLAGVIVGTYTGKHTVAGPVIEAVCIDIGIQTSQIANRTAIYAVAPKARNRVNTAYMVSVFCGQLMGTAVGNAIYADGGWIAAGSASVGFVSAALVICFLRGPHERGWIGWHGGYDMRKGVPEAPKNGHTDQEAIQVQEHPAPFRHENPVGPEGQAKQLEAKTPIEIDGIDQSSRSSQRTLGEEVPEHREKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEZ3</accession>
    <name>A0A1C1CEZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC multidrug transporter SitT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_02231</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEZ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CEZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02231"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02320"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="773"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="845"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="874"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="959"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="993"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="28"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="363"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="733"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1078"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="646"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT47105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1322" mass="143276" checksum="9EFE1445897F601D" modified="2016-11-02" version="1">MKAFQKLVGYPRLLLAGSPSKVDAGMLLLAILSAIASGIPFPLIGILFGQLIDDFNSATCDSPDTSSARAQHQHSVNDKILLILYLAIAQFVTIYTHLSCWSLNGARLAQRLRESYLNNLLRQEPSYFDKLPPGEVASRLNGDIQAIRSGTSEKVGICLSSLSFFVTAYIVAFIKDYKLAAMLVSLIPAYFLMSFVGSHYIEKYSGLMSDHAATAASIASEALSNVVVVHAFRANTRLENKFAKALKASEHEGLKKALAVGVQSGVLYFIAYSANGLAFWQASQRIADAVRLDAETASVGVTFTVVFILIEATLVLSQVAPFLHLFGAAVASFQKLREDMDREPLINGTAASGLHLSQAEAGFEFKDVTFTYLSRPEVTVLDQVNLRIPPGKHTAIVGFSGSGKSTIAGLLTRLYDPDQGQVLFDGHDLRDLNLHDLRSFLSLVQQEPSLLDRSILENIAHGLVNSSHPNHAHFKTTLLGPDLADLARQVREGQDLQAAAEKLGHNVVEIVSLVRKSAELADADAFIVALQHGYGTVVGSGGRLISGGQKQRIALARALVKDPRVLILDEATASLDSRSEQRIQGAISRIASGRTMITIAHRLSTITGADNIIVMQKGRILEEGTHSTLMAKNGAYADLVRLQTLGSTPSGKNETADSTRQSDHGSSTKHATEEGVLSIDGTGINEKTETSASQAEVNESAEEQEEPETPSKPLWSLMRGFAPVLRPHLLIIITSLLASTVVGGSFSAEAVIFGNTVGSLSPCQSESYIRSRGSFLGLMFFILAIIEFFANVTSWSGFGWVAEKTVYSVRVLSFRSLFGQDLQWHQSEGRTPALLLSYITRDGNALSGLSGSVIGTLFSITVNLFAAIILTHIIAWKIALVSLSLVPLLLGAGLMELRVLARFEERHENAYTKSVDIGVEAITSIKTIASLSLEEETLKTYRRSLKGPRKETLKVSLHASLWQAMTYLLGNLVNALAYWWGAKQIIAGNYTQTQFMIVVFSLLVSALLWSQMFALAPELTSARAAVARLLGLIEIGPDTMQGRGKRTPSLDAGFEDKDLEKIAEAKLTLPAGNQGSSVQLRDVHFAYPSRPEVEVLKGLDVEIRPGTLCALVGPSGAGKSTIISLVERLYTPQSGSIIVDGLDLTRTRDVSFRDTIALVPQESVLFEGTVEFNIGLGARPGHEATMDEIQEACKLANIHDTIQSLPDGYQTLCGPNGNQFSGGQKQRLSIARALVRKPKLLILDEPTSALDAESEKLLQDGLEKAARGITVIAIAHRLHTIRKADVIFLIEGGRCVDRGTHEELLQRSESYRLNVMHQTLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF43</accession>
    <name>A0A1C1CF43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF43"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02687"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="97" mass="10802" checksum="F958C45B03D3D30C" modified="2016-11-02" version="1">MNIHVSELKARVVSEDDRMSTATVMTECQRMCKGVQHDRSADESNTDPISGPPECSDWHVINGLAEPHLLRAETNRASPRKERKGKLAVTSPLHVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFG9</accession>
    <name>A0A1C1CFG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02639"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02180"/>
    <dbReference type="OrthoDB" id="4142157at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650771" evidence="1">
        <location>
            <begin position="21"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="197" mass="21124" checksum="31B2058BFB4B8BCD" modified="2016-11-02" version="1">MKLTLASLSLVLLGVADAKANPLLQGPDSYSLVPRNATVDSTDLASTSGQGIYDITPHPFGAPCGTTWDVTIGVQSAGDQTKASPLCKYLHTYITLPTSQGISDKKVNFIYLCPPQWPVPTSPEGYGYHDIKFILTGPTMFPGDSGTVNANLNVVNIHAIPPTDTDIPVKIGYYYDINNPTKPGFKMLTFRSITCAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFI2</accession>
    <name>A0A1C1CFI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PDAT9</name>
        <name evidence="8" type="ORF">CLCR_02400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFI2"/>
    <dbReference type="STRING" id="86049.A0A1C1CFI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02400"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02203"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF190">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="523" mass="60477" checksum="251E205E411D340E" modified="2016-11-02" version="1">MGLLSYVLDKAVIGVGVLVAGLVVYALGTVVYNRYFHPLKNIPGPFWASITTLWYFRAVRYGRGQDYQLPIHKKYGKFVRIAPNQVQIMDATALETIYGPKYQFPKGDFYDNFITNINPKRIDSFSERNEARHTERRRMVAPIYTQGAVLEYEPCVDRVIELFHRQMDRFAASGEVFDMSVWLRKYTFDVIGEMFYGREGGFGFIRDNIDYGQWCYLMDIMPNPIAALNNIPWGFRNLYFLFELLYPETRAGAKGFSTTIKQAHEAMRQRLDDMAAGRPYNPHDTLSKLIDIAHDEKNDFHILDATTEIWAIIWAGSDTTSIALTAIFYFLHKHPHTLAKLRAEVDDAFATGALKYPVRFNDAVKLPYLHAVVLEAMRVHPSLGTGLPRVVPHPGVEISGRFFPGGTGVIMNQNAVHFDRNVFGADAEEFIPERWLRDDDDGGRNAAYMERHMMHFGYGKRICIGRHITNTEMYKLLPVVLRDFDFDLVPDEKGRWEWEVWRGWFHQQKNVMVKARRRSSERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFV5</accession>
    <name>A0A1C1CFV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03722"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="97" mass="10576" checksum="CFDACF8117B0E0C0" modified="2016-11-02" version="1">MPIAVAIAIAITVIVIVTTALSRMRTAMLVQLTDESGGRENIAENGIEVTRSQSGQSSLPGQLPVQSTVQSIHLASVLVDDLDNFALYIWVWVWVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG55</accession>
    <name>A0A1C1CG55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG55"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03696"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01938"/>
    <dbReference type="OrthoDB" id="5395704at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650792" evidence="1">
        <location>
            <begin position="22"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="186" mass="20235" checksum="91D8F37C2CDE60C7" modified="2016-11-02" version="1">MAFLFTALTLIAGLLMRTTVAFSGNFELTNLVVSSPFQADPYSVESTYVEFDFCDQDTPEVGSTHCGVQWSVGLSPPKISPNTCDNTSFSVTVTSWSGVANLSLKLGHQYIDDRSVYLLTFSCPKDGAQTDPRDSVGKAPYNVLSKYANFNLTYPHTPFYECDMTNAECKSCDGETILANITSAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG66</accession>
    <name>A0A1C1CG66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YagE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_03511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG66"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03511"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01906"/>
    <dbReference type="eggNOG" id="KOG2861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242766at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="201"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="466" mass="51743" checksum="E73A18CC0D8CB329" modified="2016-11-02" version="1">MRQAAARPVTGLGGQLVCISSRRAGHGYGHDGLRQPGFRPLHASPIFQRTRRRGFFSSNHSLLSQTATRKDGNKDKADTGMDSSAAASIQKRKTARSPGTKTSLRRVGLEAQRSKAGLTRPGLRTTEGADQTLKLVTAYAVADQFDLTKVVEILRSKGYEPDPLETGLFPQVVHVQIPISSIYRSTNPAAAHLSSTEVGDVFVFPSGTLVTWALPDGFTSYFATRTLLPAADNPHKEPIETEDLDYIEDPTREHSLIRGDTIILGTKRPEHHDDQPADQTKSQFQTVDTVLTKIAFSSGFARSTKLAVLETNLSTYLASTADIPALLSKGSRLPFKLSRDFILRKTGQLLLLRAQLNLYSELTDSLPDLFWDSRHELNLENYYDQVGRALDVGIRIKVLNEKMDYAAEIATVLRERLSEKHGLFLEWTIIVLIAVEVGFEVLRLWKEGFWAEVWEGRVGELKGEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGY8</accession>
    <name>A0A1C1CGY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative alpha/beta superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGY8"/>
    <dbReference type="STRING" id="86049.A0A1C1CGY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03627"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04605"/>
    <dbReference type="eggNOG" id="KOG4391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF64">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="293" mass="32623" checksum="6CA6EBBC8611684D" modified="2016-11-02" version="1">MVIFQNKIIYMPSVPPFSRSERVDDYAAQCRPVEWVERDLTAADGTALKLLEGSIVASVDSDVTEHVVVIYFQGNASSLPPRLPYLSNILKRLARDHPGGRKYTIVALSYRGYWKSKGSASQAGIELDAEAALTWVQGRYDRGRTKIVVWGQSIGAGVASVSLANLLRNGQDNLRRFSGLILETPFVDLKRILVALYPQRFLPYRYLTPFLRSTWDTRTALRRLGASKPTLKVLILEAGNDEVVPPGQAETLEGVCIEEQLEVDRKMVPGALHTEVMVKGQGQNHIVKFVQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH59</accession>
    <name>A0A1C1CH59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma-glutamyltranspeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH59"/>
    <dbReference type="STRING" id="86049.A0A1C1CH59"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03354"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04541"/>
    <dbReference type="eggNOG" id="KOG2410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2015213at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="609" mass="65939" checksum="64C4CD2A41B6189B" modified="2016-11-02" version="1">MGSTGKDMKREAVFPGNTAQFVQFASRRSVVHSTKGIVACTQPLAAEAGQRILKQGGNAADAAVAVAAALNMAEPTSTGIGGDMFCLFFDAKTKKVHALNGSGRSAKNTTLEQVRQELGVSSGKIPTHSPLSVTVPGAPGGWVDTIEKFGSGKLSMEQILTPAIEMGEQGFPWHDHEPDLRRASPNFREMLKRDKNAEDFVRAPRAGEIMRNPNLAKTFRTLAAEGKKGFYSGRIGQAIVDVLKLTGGHMELSDLEDHMSRGAQETEPISLKFSAQNVKKQGTHRVTNGSPDNHFVELWEHPPNGQGIVALMALGILEELERTHQIPAFAQEDHNSAIHLHAVIEALKIAFADASWWVTDPEFMKVKSSELISRPYLAQRAKLFNKDKAGQFDHGQPGPSPAQNHSDTVYFAVTDKDGNGMSFINSNYEGFGSGIIPQGCGFTLQNRGSNFELGPENHPNIYQGGKRPYHTIIPGLITYGEEADRQLHSVYGVMGGFMQPQGHVQVLLNMEVFGLNPQQALDAPRICIGAGMPKEGDTHGTVINVEEGIDEAVVKALKQMGHNVEVLHGFSRAMFGRGQIIRRHVDEETGQMVFSGGSDPRGDGCALPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI27</accession>
    <name>A0A1C1CI27_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">pdcA</name>
        <name evidence="17" type="ORF">CLCR_03989</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI27"/>
    <dbReference type="STRING" id="86049.A0A1C1CI27"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03989"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08310"/>
    <dbReference type="eggNOG" id="KOG1184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF11">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="6"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="204"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="408"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="570"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="578"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT48160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="600" mass="65626" checksum="FC855A4EFB384515" modified="2016-11-02" version="1">MATNIDLAEYLFRRIRQVGVKAIHGVPGDYNLTALDYIEPAGLDWVGNANELNAGYAADGYARIRGVSALITAFGVGELSAINAVAGAYSELAPVIHIVGTVPTNVQDAGLCMHHSLGNGDFRVFADMYKKITVAQANLRDAATAPAQIDRCLRECVIQSRPVYIELPSNMVRAKVSAAPLTTPIDLSIPLNDEGFEDTEVDLILNKMYASRQPFIVVDGCTSRYGASEEANELVRVTGFPTSATPFGKGIINEDYPNFHGIYAGIAGNEAYMPWAQGCDFVLKLGPLESDVNTFGFSTIPDPKSSVVFHRDHVEIGGIKYQNLHIKSLLRRILSKLEIAKLPQYNPYIDLGSPRAELMALPPTGKDDIIDQATFWRRISTFFRTGDIVMAETGTIAIGSREMVLPAHTTLVSSCIWLSIGYMLPACQGAALAQREMIAEGLRPNGRTILFEGDGSLQMTAQSISDIIRNRLDVTILVINNDGYVIERWIHGMKAGYNDIQPWRYLEAPNYFGAPKDDPAYPVVTRRAETWGQLNDILAEPALQQGKGLNIVEVIMGREDAPDVLKRLVQSTKRRNSGPDTTPEQHQPSSTGEKAMKVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIN2</accession>
    <name>A0A1C1CIN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="10">dUTPase</shortName>
            <ecNumber evidence="10">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_04350</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="2">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="10"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIN2"/>
    <dbReference type="STRING" id="86049.A0A1C1CIN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04350"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08519"/>
    <dbReference type="eggNOG" id="KOG3370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="12">
        <location>
            <begin position="89"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT48383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="225" mass="23351" checksum="86086DEC0D233478" modified="2016-11-02" version="1">MTRTSTPPPPATAAATATATAPDNQHETHHLPPSLPNSPLAKRLKPDTATTSGVKMSSTSNREESAVPVPKLTSTSHPPLLIKKLSADATTPTRGSAFAAGYDLYAAKPTTIPARGKALVSTELSIATPEGTYGRIAPRSGLAAKHFIDTGAGVIDADYRGEVKVLLFNHAEADFRVDKGDRIAQLVLERIYTPEIVEVDSLEESVRGAGGFGSTGVGVANTGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIZ4</accession>
    <name>A0A1C1CIZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_04124</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIZ4"/>
    <dbReference type="STRING" id="86049.A0A1C1CIZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04124"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08618"/>
    <dbReference type="eggNOG" id="ENOG502QPY1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650834" description="Proteophosphoglycan ppg4" evidence="13">
        <location>
            <begin position="19"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT48493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="43938" checksum="1E25561F870DEFF7" modified="2016-11-02" version="1">MAASFILSALALAGIAQAHVAAFAPGMYCQNGTDPNNPNLNSNAPVSPLYNLTQDQWWFQHDRGCDKVPPPPGVFLELPAGGSFNVDLANNQAFSKLSWDGTKTSDWPDGGDHPDDWTGWTGTGEGCIQDSGWIHTQNETSAQGTAFAIAYESDLNKITMEDLVVFTVLEHTPWKRSATYQVPAAMPACPEDGCTCAWLWVPRGCGQPNIYMQGFKCMVTGATSTAPLAKAQPPVMCDQDTSKCVKGAKQMIVWNQLTGNNVVTTGSQTPAYNLRNGFAPGPQDDIFEDSASAPSPPASSSSTPPLSAISSASISITSIPSAPTHVQSPTTPSSEPVFSILPVSDSPVSSSRTTFLTAVKPASMSSGISSIPSVATPVTPISSIGGGSPATVTVTVTASPTHSGHHYTDCWVDGDELDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ11</accession>
    <name>A0A1C1CJ11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ11"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04047"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08561"/>
    <dbReference type="eggNOG" id="ENOG502S7AM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142">
        <property type="entry name" value="METALLO-HYDROLASE/OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="527" mass="57562" checksum="17D59AC3A468F08E" modified="2016-11-02" version="1">MSVAVKHLNADTSFLLTFSSKPNSPTNEVASRDGAFSVLIDPWLDGPSIVTAPWFAKTEHKIPSAVQHLSELPAPDVVIVSQNKPDHCHKATLLQLPPDGKTIIAADPGAAKAIKSWDHFDPAKVRGLRKYDPKVKSGGSLRLSIPALSPHGFPGEVHISFIPAKHYMTGLHNAIGVTYRPPTRTKSIAPIATVDLPKTTRYFHVPLSPMTVPPASPQPPLTPLANRPMSFDQPAQVDNVIQAVGPFSFRGHRPRLSRSSNTASSEFLPSTDKPIIRVSPESERDEGTIVHNIVTIPDRSPRVGAAFDFKLGPLPFTHLNSPPTPPDSPAWEPLSSPSNPTSTPTSPSPTSPLFHQRCISSIPSHQRSLSSVSSMPNLITPLTPARPQAVSIIYSPHGLPLSDLQPYIQNHLVRLPGALPLTVLFHSFDYAQNPWYLGGNIMMGMYGGAEIARAVMARCWISAHDEQKDDRGLSVKKLRVKRIGADEVRKHLGEGEHGEWLRQNGWTCDVRQLEVGKEMFIGPLRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJC5</accession>
    <name>A0A1C1CJC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJC5"/>
    <dbReference type="STRING" id="86049.A0A1C1CJC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05264"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="116" mass="13232" checksum="B74F18C2EB5E4A1E" modified="2016-11-02" version="1">MTRRLHWTLHTGRSEMILTRLAFQVSRIKERVEEKEGIPPVQQRLIYGGKQMCVIRPFIIHLRLLRLFPLIFSLTQPAQSRNSVHSGMVQALLPVPVPVSRAFGFSAGKTCVNVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK30</accession>
    <name>A0A1C1CK30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK30"/>
    <dbReference type="STRING" id="86049.A0A1C1CK30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04958"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03051"/>
    <dbReference type="eggNOG" id="KOG1455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="28"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="329" mass="35886" checksum="9EECDD371529F0F8" modified="2016-11-02" version="1">MAATTEGEFATRDGTKLYTKTWKPASDAARAVLIFLHGFSDHINAYYDLFPTLSSSPFNIAVYGFDQRGWGRSCKKAADNGHTGPTSLVISDVHDFALHVASLPEAQGKPLFLMGHSMGGGEALTYMLSASPDFSNRPAISGLLLESPYIEMHSSGQPSSMKVQAGKLASMLLPRMQLKQKLDATYMSRSEKVRQDWIDDPLCHDTGTLEGLKGLLQRSADLSHLSHGRPIHGFSTKLPCPLWISFGTGDRVLSHIAAQQLFNVVEAPNKDKTFKLYPDAYHKLHAEPDGVGEQFAKDAGEWILVHVTKQAEVAQVGETQSSQEVVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKX4</accession>
    <name>A0A1C1CKX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_04685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04685"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02766"/>
    <dbReference type="eggNOG" id="ENOG502S2VB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16772at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="555"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="132"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT49160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="583" mass="65776" checksum="464FACAB8EFAFE5E" modified="2016-11-02" version="1">MQRLKHSLSRLSLSGRTQPSEDAPPPKSLDAEVKDNETTEHEIKDPLNTTDSTYICIDTPESSKMDSCPVCHEHFNDDTPGNCASCVTNMLYTCRFDLARVLIEKESLQKKVEAIIGPEPEQPLDEETARLRKGWQRQQEKIEEQREKELQEDMQRELVLRQKEVAVRRAHAQELRANLEQRKANLAVAKDALARHNKQKEQELKESSEKLKAQYDALHNKTVDTRAILCREAASLMRLSHSKKKTKDGTIKDRHYIAGLLLPDLKEINNMRCTELTAALGNATRLIFLCAFYLGIRLPAEITLPHRDYPLATINTPLTSYLNQRITFPGSGSSLSVPSSPTASRLDLGTAPKPRPLYIGSDDYNESVAQFAKKEPLAFSYFIEGLSLLAWDAAWLSRTQGFVAGTETWETVCDIGRILYQMILAQPQSAAITRVLSQRDVHLRRRRSSSMSSPAREEKESTFPARLGSYSHDSAHTFLGSAAAAGDNPSRNWRLNRYAMISDPLRKHLLTEMNNAEWELLDEQEWDDGGEKMDDAVVIKARVMDGKEYDDARSIMTPGAEDEGARVSKGKSGWTKLKNRDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLE8</accession>
    <name>A0A1C1CLE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative calcineurin-like phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLE8"/>
    <dbReference type="STRING" id="86049.A0A1C1CLE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04727"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02658"/>
    <dbReference type="eggNOG" id="KOG3662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="568" mass="63476" checksum="95887DA9341C02D8" modified="2016-11-02" version="1">MDPQLVDPHTYPDRPWPLSSLTVLYTDLYLRRSYRLLQERLQPDATLFLGDLFDGGREWGTPASSSPEQRYKKYGSRFWLKEYIRFSNIFLRSWFTGSSVSPAEPTGRRLLASLPGNHDLGFAAGIQMPVKERFDAYFGPLNRIDIIGNHSFVHLDTVSLSAMDQIDPKTGSSGAGDGSAAATASTKIWTPVEDFLAEAKTIRAKAIRHTCETRFSWKSPSPRSLVPEVRQAEQAEASKSSQNSLYPVSSSQFPTIILSHVPLYRSGEANCGPLRERGSAIPLQAGYQYQNVLTPLISHDIVKHLTAEEITMIYSGDDHDYCEIEHNEFTGRIREITVKSMSWAMGIRKPGVQLVSLWNPVDVEKAMSDDPNLSTPRDTVQNHMCLLPDQLSIFIRYGQAAGLTLFLLLLSALRYNPSTAATAHAATLLQHEKSDPLLPTSELSRRHESSNSKSSCVQSGGTSHLSTRKPGYGHIPASSRTASRSPVPSKPPYIDHARNAYHLGTEDVSGVNDHDHDHEDDWGMPKRVVAMARRRNFPPATRLAYLRREVGRTVWPALAVYMWLLWHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLI0</accession>
    <name>A0A1C1CLI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3 10">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PYR1</name>
        <name evidence="12" type="ORF">CLCR_05019</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3 10"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLI0"/>
    <dbReference type="STRING" id="86049.A0A1C1CLI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05019"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03263"/>
    <dbReference type="eggNOG" id="KOG1377">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="11">
        <location>
            <begin position="34"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT49339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="274" mass="29789" checksum="4DB7E22D4BF4D176" modified="2016-11-02" version="1">MASKSTCSYAQRAAKHSNPLVKKLFEIAERKKTNVVLSADLTTTKELLAIADSLGPHIAVLKTHIDILTDFGPATIRGLTELAQRHDFLLFEDRKFVDIGNTVQKQYKGGALMIHDWAHIVNATILPGEGIIQALDQTIREGGITERGILILAEMTSKGSVAVGEYTRLSVEIARKYPQSVLGFVSTRELSSHSPDATPEEDFVVFTTGVNLSSKGDALGQQYQTPTTAMAGGSDFLIAGRGIYGAKDPLTAVKEYQQAGWEAYERRASLSRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLV1</accession>
    <name>A0A1C1CLV1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLV1"/>
    <dbReference type="STRING" id="86049.A0A1C1CLV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07656"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09755"/>
    <dbReference type="OrthoDB" id="5431013at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18451" checksum="34249CD855533A68" modified="2016-11-02" version="1">MAEPGSVAPINRVAADGFKLSLLLNAVSSDVANAGLEVQAISKGVTLFSMMLKHTSQVLQAVDSVHSQEAVETAQSIADEGTRAFDEINEMLERVRTAQRADDPSSSPVQQRFKRTFKKHRVTYLLAQIESLQLSLSVMLQILQLGRLMASTSRRFETVPVHTRDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLW9</accession>
    <name>A0A1C1CLW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_06824</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06824"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09752"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="15"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="501"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT49487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="610" mass="66267" checksum="17920EB57C23DAE5" modified="2016-11-02" version="1">MAKGAKRPLQLPNQQLLILAACRLAEPVASTSVYPYIPEMIQSFNVGDDQVAQWAGLMSATFSLSQCLTGVAWGRASDRFGRKPIIIVALTCTMLSSILFGFSKNLAWAFITRSLQGLSNGNVGIIRTAVAELVPQKELQPRAFSIMPLVWNVGSVFGPSVGGTLVHPAERYPQVFGKMKLLQEYPFALPNLLISVLFMGGITAGFLFLQETLEEKRTRRDYGLILGRFLTRPCVRRPHQLTQENNEESEAFLSGISSEMSTPVSGSQHAIHSLPKQTPGWGEVFSRQSNINLLVYTFLAMHSVAYDQLLAIFMHYPVQSIHDPDVRLPFKFAGGFGIDSKEIGLLFTAYGVFGMIIQFFVFPPFARKYGVLNCLKACCVAFPLAYIATPYTALLPTNSLRQGVMMVIMLIKCFCGIFAFPCSTILLTNSAASLKILGTLNGVATSISALGRAAGPALAGLTFTEGVDIGYVIISWWTLALVAVIGAVPVWFLVEMEGFGDSQEDDSDDEVDIEEDDDAKASAISSSDAHLRKHTPSSVFEDAVEDDQLTPEGSLLRPSNPPSRRQSLQLRRVSSPIGLGPGVIPHGARRYSSELGATRSGFGVGGTAYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLY6</accession>
    <name>A0A1C1CLY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein atp12, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atp12</name>
        <name evidence="7" type="ORF">CLCR_07326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLY6"/>
    <dbReference type="STRING" id="86049.A0A1C1CLY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07326"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09775"/>
    <dbReference type="eggNOG" id="KOG3015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5322896at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT49514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="372" mass="41208" checksum="5D43A7FBD35AB0B4" modified="2016-11-02" version="1">MRASSIRVASIASLIPRSQSSRGRVAASAIRSISSSTSRCATALPITATGPPPSAPVPTSPQYGDRIEERRRKAELLKQGKELRAASQPGSKLKPLQKRFWKEVHVTEAPEGYQILLDQRPVRTPSKSILTIPRSKPHLAHAIAIEWDMLESAQQALKNHNIPMTSIAARAQDIIEAEAKGDAKVRNEIITTMLRYLDTDTLLCWAPETKSTSPLEMQTGRPESLRQVQIKTAKPIISYLSTSVWPGVDIKPVLDENSIIPTKQDESTRNVIKGWIAGLPAYELAALERAVLAGKSLLIGARLLIEWSEEFRDMQRDSGEPRFGIHEAAEASNLEVRWQTDMWGEVEDTHDVNNEDIRRQLGSAVLLVSGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM57</accession>
    <name>A0A1C1CM57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM57"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06996"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09793"/>
    <dbReference type="OrthoDB" id="4157125at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="554" mass="62287" checksum="60B6778B213E99A6" modified="2016-11-02" version="1">MQRRAEILATIDGDEARDEADNRRIPLELAMIDYDSRSSRTPSCSVADWALSEASPFPHFTVDVVSNASLGAKHPENPLEHIDKQVHFVSGFQKLAAQRRKVRRLRVRARDGRGHLKATRHRLHGALQRFFKAIEAHPLGFDSDPTLMKDLETAEVACDELDSEDIAQDIVESDLLPEEWDLEDSERRLYEAVLGPSASDEEDDLDIDLGTRAQPDGRPTKAHLDGTYLPGPDEATADERLLALVEERRHLKESLENQEKEYTALSKDMEMRMAAGVPIDIFSRNTLEDFGERRGQLLKHIARLSFQISELEAMSSEASLHDSRQSNVLFGLHQFHDLETRKYIQAPEAGDSPTLQLYEDDDGGGRKADMDSFLGQPVLEQLERVDGLQEQHSVPALVPYSSFMWEVDDELLDNLTNYVSLWLLGCIQSSWWSFTRLAAWVDPTGKFTVQTTTELVKTTWFEDGAGLSSSFVWSEDPRSSIVSEPHLDATLTPTSGTVGMWEPLWQVDGPKRRHTSGYSGGRSHQRRVSSHSHPGTGRVERDPPVPSDSVWLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMK7</accession>
    <name>A0A1C1CMK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMK7"/>
    <dbReference type="STRING" id="86049.A0A1C1CMK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07327"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09918"/>
    <dbReference type="OrthoDB" id="4356615at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="372" mass="40697" checksum="F218B86A9C2CBC9D" modified="2016-11-02" version="1">METMDEDDRADSAISSENNKHSKRDRLKGALARTKSKFKKENERLKEAELPEDVNDFLAAGKASTSSAGRSFPQPSTVTPIDEQSTTPTSTRPSTSDSFTNPFAAQRSPRKIAVPKIDVSNAQRWPRAQSVGTTEQDINDFLRPEYQARSQSASSFSSQPKKKGRGRKLSVSFNEAPPVIIGEGGDDAPTPPVEIGKARQRARSASPVSRRGQHPPGGSMDGTYGKRPSPVPPPAGQVHAPPDVLRPRMVQRVQTGFAVDSVGTSGLDKEFEMTLRVGETANSPASRETPEIIAPRPVRIVHPPPAVFEESAESQTVKKEPASTNLRQKFREGDALRMHLDKEGPDVVDEIRQGRPVRRGTTQDKQEPSNWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CML0</accession>
    <name>A0A1C1CML0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7908 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CML0"/>
    <dbReference type="STRING" id="86049.A0A1C1CML0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06587"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08672"/>
    <dbReference type="eggNOG" id="ENOG502S903">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4161759at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057230">
        <property type="entry name" value="DUF7908"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25485">
        <property type="entry name" value="DUF7908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650912" description="DUF7908 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7908" evidence="3">
        <location>
            <begin position="256"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="914"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="953"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="980"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1146" mass="113487" checksum="35B30C5B63360F70" modified="2016-11-02" version="1">MLIPVALLASLTVANAFTNADITVRVKQTRTVTVCPYPTDLCGDKGQSWDPALPHGGDWNDWHGDHGGRSGYNGGQGAGDDHTGGHGGNNSGPPKDIGGHDGQAGDGHVAWGDWGDHSANWSGKESSTLRRSTTSHSHFTGKTSPGPSRSTSKPGRTSYRQPSASSDSTTHATSPSTSSHQWTTSSTPTTSNPADLPSYSSTSHRSDEETSTTSHSGPHGTSSTTGTPDTTSAPTVEPSTCIPDPAPARISGDGSFFVSLSLNLGQSRYHKRQTTTGYIGFSGTEAIAVTDPSLAWALTLDEVTQVLGFSGASGYVGFDSLSVDAPVRKTNDDGSYAPAFFAGWTIDPATSSISFGTAQFCTVANTTLVAYWDGVVPDGCSAVALTQIQIDTVPTSSTSSATTSITAATPETTTSNAAATTSASSSPAQDAGSPGSSLTTSTAGASSLPATTSRVSSVSGAPDQDDTSTSVGVVGPSGPSSTSTSTITVITTTSSSAPVGDTAVAGTSTTTVSSSTDVELTPVSTTTLSSNSSNDSALPSSTLTTSVAPDAVSTSTPSTTAITTESTPCSIGAKPTFSLLSSGSRGVPDGQPAISVPSGSPAYPFDYLGFSSGTPALFTFDTQGRLVEVASGNIAGSPQPGQNAVSFLFSPQTTVDGLGISPASCSLSCPASGTGLPQLQCSVWGYSTFITQVAFPYLGIANVVPTDGLTLTLLAGIVSQDDTPTSSSSTAATSTTTSDIALSTTVSSSDPASSSASGGSATTSASRSTGPSTSASDSPSTSVGSVTSTTSAVVNVAETTTTSSSAGIAATPTSSSDLNDASTTSSLTAATTSSNIAGPSETSSASSTDDSTASTSFSAQGDTSTTSSFTSATTTSVDGADVVAAPTTMTPDSTSSTTSEAVYVADPLATSSTFSSVDSAATTTSSTNTDTATSTSSRTTTSADPTNVSADHTSSTSAVLTTSSTGAALPHITTPSDIGSSTTSTMSSTTTSSPDPSVVAADPLNTSSRTTTTTNDVAIVTTTPVQLAPPVIITSDPTSSSTSTSTTSSSTLANASDPTPPPPPTSIGSEGGDDDSEEDVSTPTPPPVPTPGSDNTGDDDDEPATGPTITTSSAASVPTPAGGSNDSATGDEDNDDDHPGVVFEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNH1</accession>
    <name>A0A1C1CNH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-ketoglutarate-dependent sulfonate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">JLP1</name>
        <name evidence="8" type="ORF">CLCR_07179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNH1"/>
    <dbReference type="STRING" id="86049.A0A1C1CNH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07179"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08981"/>
    <dbReference type="eggNOG" id="ENOG502R0XT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000008">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF9">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_3G01010)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="86"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="399" mass="44680" checksum="7A2B9CE0F20F9D5C" modified="2016-11-02" version="1">MAPALVEPAITDFVVPKKDTLGLPEPAYDRLKKAGIDLSEGYPYRPNRPLYLQDVYNIRNQDRPHNDACARADKSKSALLSAATKVTDLTAYIGTEIEGLQLKDLTDQQKDELALLIAERSVVFFRDQDLSPQQQKDLGEYYGEVEIHPQVPQVPGVPGVTVIWPALQAQEVAASFRKPGGASRWHTDLVHERQPAGITHLHNDTVPPVGGDTLWASGYAAYEKLSPDFRKIIDGKHAVYRSAHPYLDRDNPTAGPKYIERTHPLVRVHPATGWKALWVNRAMTDRIVGLDRAESDLILGYLYDVYERNVDIQVRFRWTPGTSALWDNRITTDYHLPCWGAPQIHNASWDYAGAFPRHGTRVTSLAEKPYFDPNAPTRRQALGLLGPDEQQVDGILVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNI6</accession>
    <name>A0A1C1CNI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07810"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="89" mass="9571" checksum="5152D03423152DA1" modified="2016-11-02" version="1">MDLSQSRINPLGIIAANVRPRTENEGSIAALYEWGDEITTDLMDRDFQSDNGQPGPLRRADEAGSGKADEGAQRRSLKVVDGVEGARTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNY7</accession>
    <name>A0A1C1CNY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UbiE/COQ5 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNY7"/>
    <dbReference type="STRING" id="86049.A0A1C1CNY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07486"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05769"/>
    <dbReference type="eggNOG" id="ENOG502SAHW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="281" mass="31261" checksum="A5BB520264F8E879" modified="2016-11-02" version="1">MSQSHLDSVRSMYDERSEDYDENEVHIKQARDYCEWAGLRRGESLLDLACGTGLVALEAKRRVTGSGHVVGVDISEGMLTVARRKAAAAGLDDVRFFNHDIISDLAAIRDDILPDGAEGFDVITCASALVLLPDPLRAVRNWQALLRPRGGRLVTDVQTKDANLVMNVFSDIASRVGESVPWNSELLRSRRELERLAVHAGLDVQTVFETDAYAKTRYHVDDARQIFDQAVGKAMFSNFGRADIRDQARDLFVQRFTDMAGSAGSIEEETRFWVLVATRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPJ6</accession>
    <name>A0A1C1CPJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPJ6"/>
    <dbReference type="STRING" id="86049.A0A1C1CPJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07568"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05576"/>
    <dbReference type="eggNOG" id="ENOG502SUTN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3830579at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24577" checksum="28BC50263793CF7D" modified="2016-11-02" version="1">MAEATEVVFLSLKEGVDSQSPQLKSTLETIIKHGQPHRMYAGAQVEHPNVQNLFIDWSSIDHHMQFTKWEGYQAFLNGAVELCDVPPSLFYVHFEPFPPTPAFSEVTEFITIYFPADYSPDDQKTFHEGMKKFGSIVQRDWEECRGTAGGWVAEEAEDPKTGEKAKAYVCLLGWPSVESHMKYRETASFKDNIGLLRGAKDLKNVVMVHVASKEFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPZ5</accession>
    <name>A0A1C1CPZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rai1</name>
        <name evidence="9" type="ORF">CLCR_07450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPZ5"/>
    <dbReference type="STRING" id="86049.A0A1C1CPZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07450"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05469"/>
    <dbReference type="eggNOG" id="KOG1982">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="284" mass="32566" checksum="FE629B2B8745D890" modified="2016-11-02" version="1">MVAPFSKLDDWEMNATLFQGTIYLEENHAKKISSRQQQYSSAGRPGALSQDLMSFWGYKFESVSLMPTPWPETSREYIESREDEPVSNYAQYCSIVRTGFGKVKMILGGEVDAVMAFKPEDKSRPIDWVELKTTAIVTNEKEQIKYERKLLKFWAQSFLLGVPRIVVGYRSQQGILERIEELDVQTIPEKVKLKGKALWDGQTCINFAASFLEWLKDIVTSDGVWRIRKRENVPVLEVYKLEEPGHGDILSPAFIKWRTGGLEAHQQQLRVLQEQAKDDGVEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ20</accession>
    <name>A0A1C1CQ20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein sip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sip5</name>
        <name evidence="6" type="ORF">CLCR_06674</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May negatively regulate the SNF1 kinase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ20"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ20"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06674"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05408"/>
    <dbReference type="eggNOG" id="KOG2789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21471at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24139">
        <property type="entry name" value="SIP5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315:SF1">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="556"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="742"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="782"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="815" mass="88318" checksum="A6BFC4F61C3BFD89" modified="2016-11-02" version="1">MGNSQTKEARGHGSSGPRVIDSASPSTRPDGQPNGSETSLRPGHPSRQRRSSRPDFSFLGIGGTSDQDATSLEQRRETKVEREARKAEKERAARLKERERSMKEEHVDGGYLVTQGVYVGAEDFNKAVVRQLMIERRLAPFWRGLNDYSESWAEHQLMAAARGMAIPPADEVPPELEYQLAKNVTKDWNKESALKSLTVPIGGRSQSFQSDSSGPLSPTLHSLPLPSPGSPPLSGSPGGTTFRARAKTLASLATSSRGNSHTNMTPRELQLPHDPFVNGQPIEVYLYKEASECPICFLYYPPYLNTTRCCEQPICSECFVQIKRPDPHPPEHEQPDPNAPPVSEAEREAQADGLLVSEIATCPYCKTPDFGITYTPPPFRRGLAYGLGSQPYQVTSAMSSQTSFSSGNLSPGPGRRRGTSLSANAPEVITTDKIRPDWANKLAAARAHAARRSAAATALHTAAYLMNGQAADPRAFAAFSRRGVLRRPTLENGENGPSASMSALAMLAERHAQRQQEAASETRANAFLPPPRGSSSRRSRMDDLEDMMMMEAIRLSLASEEERRKKEEKDAKKAAKKKDKENKKAEKAARKNSLFTVNSNGSNGDASSSQMERSQSNLSLGQDDDSTSSKGKGVERSETPPVDGAKPEDEPPRPFYVPALSLSGTASQESVASSIPIPTAAEPFRRSHLRQMSNASSTSSSFVEAGPAATFPGTGTPPPGSLEPMFNFRSLAAMIGEDEKDNDSAHVENATRDQSPKTRQFAEDENPFRADEDSSVDDLSRAASSNAEPKQQDNLGTAETKAQPVVEASATVSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQZ9</accession>
    <name>A0A1C1CQZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQZ9"/>
    <dbReference type="STRING" id="86049.A0A1C1CQZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08394"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09574"/>
    <dbReference type="eggNOG" id="ENOG502SSBZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5549748at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="3">
        <location>
            <begin position="225"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="513" mass="60997" checksum="91CA8AB98295C6E9" modified="2016-11-02" version="1">MSRYRGDPRYSDGNLAYRDPPPQRWDTERFAREREVRAPAPPAPDYPPRRAPVYEEQRYYEEDRYGPRGATERRYFEETDYYDPRAQRGQMVPYAPERPARPDPIPRPGIIRRQSSLDTFDRRPARRFDDYDELDSPRRAPPPRELIPVRAPSPRRYPRYDEKYYDEVRVQDPDHYGDDGFREYREREWVRERKRNSPSPDRRTVREEIIEERKEEIIEEKPYPRRGKTRMPKRLVHTKVLFDLGYPYYEEDERTIIIEKALGPDNIDEVFTKSKEYREREVTTTRLIEAPPVVVSNPAPSMRAPSVHGGDVVFEKMEKVERIETVPIADAPRSVRDWDGLSVRSPSPKAHRSRSRRRSRRGSSPGEIVKETVVEKKEVIRDVSPARTHRSHGTSHRRGSFDSDDATIIERRVTRDEFEDSNSVHVGPLALVVDRKPQRSERNIKEEIRRLEAERRELRRERRYEREGGEIVKIERVRERTPSPRGEVIIERRGEEVLEVKKDRRGRMSLIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRD2</accession>
    <name>A0A1C1CRD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_07980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRD2"/>
    <dbReference type="STRING" id="86049.A0A1C1CRD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07980"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09700"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF12">
        <property type="entry name" value="RFEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="76"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT51066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="955" mass="106411" checksum="299572ED6884B91D" modified="2016-11-02" version="1">MASAYAMPPYQNNTHLPPINYSQLPPANQSYMPQQQYRNDLPRYSAAPAPPPVPSPAPDNRYNQHMAPQSSMTGLPPAASLPQPHSQQPQQPPQQQAPQAYQPQQPPRQSYPQPLAPAPPRPDPLQPGYGQPDNRQQQWSGAEGIPGMPVEVGGRDPTKTHVVGSQGRRGILPSAPGRPPVMPNGVNGSPKSSAVPQKDADGKFPCPNCTKTYLHAKHLKRHMLRHTGDRPYMCVLCNDTFSRSDILKRHFQKCSVRRGNPTGASHLSNPAAHIKKHQQKQATASPASATTPSSAVMPNPPYTTAAMPNTSAPTTSAPTPGMAYPMQSNGQNDMQRQGQPMQPGSGPGPMDTNANSWGPMQHPRSNQMMYHSNSTPDHFGMQPGGGDDKRNVMPGPHHMGDDWNHMFPSGGNEGYMNPMFGGYEQSQNDVKKEFESHEGGSNGYYIPSTSLGADGTLGPPLWNLHASQQDLVKSKVNSLLTFLFPGGIQESLQDPQNDSLVRSCLTVEAMQHFLDLFPNFQGHFPWLHLPTFNLATAYDGLILVIICSGAVYSDRVSQHQVRALMQLVRAGIERTSRLLRNLEPGTLRTQFSSSGLEFEELLALQILQSLFVWHGGPEDRAVARAESKRVLYLVRQLNMLTLAGPEDPLSYSYLHCLQPGEEADPSRWDWRAWLEQEKRSRLMYMVYLWDAAMCIYFNVAPQFSSAEIKLPLPCDDAAWEAPDAESCAQALGLRGFEVQTRVNLSGSLRLKQLEMHHAMSALHSTSVIMQPRTTNVYSKFILIHALHVEVWQLQRQRTFTGSMEPSYSSAEETNNMEKSINVALTRWKQVWDRDYALQYPPGNGYRPIVGRVGFCRDGVHFYWLARALMQPNRTHDWQLPADDRLRQVLHGLKKAREWSRTDGAKRGEEPGSVAYIDDDYASETLELDMRKLFRPLQDLVECPGTSLQTSAVVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRF9</accession>
    <name>A0A1C1CRF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_08954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRF9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08954"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09728"/>
    <dbReference type="eggNOG" id="KOG3945">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="267" mass="29646" checksum="C32058BF75BB8772" modified="2016-11-02" version="1">MAGKDGNGRPDSAFPREQLNKDLQKLLDKQDDIWDNIYEGQGPDTTETSVRYAAYANRLRTIMLSAHRYVAYTSDIGESFRPVAHPILVRSAYGISWAYILGDVSHEGWKAYKRNQRLAAPKGDEHFDGRQKEPMGKIDAIPPTHPVHIPAIEDYKAVMAQRAVFQSIASMGLPAFTIHSIVRYSGKALKNATNATVRTWGPIGLGLAAVPALPYLFDKPVEEAVEWTFYTAFRAIGGENAVGVRPHVGRNEALQVETQIAQEKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRK6</accession>
    <name>A0A1C1CRK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative MscS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_07984</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07984"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06932"/>
    <dbReference type="eggNOG" id="KOG4629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF14">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="428"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="887"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="895"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT51137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="962" mass="107169" checksum="3B5661E05554A77C" modified="2016-11-02" version="1">MSQHGHYKKFSKDGFEPLNPKTSREMTNPNDVTIDIPLTKVNTTGSTTGARKADATSPSTTQYDAGWNPNQLDEKQGHHFHRGPGGRRRRLVDQARSNKDKDDGSLNAVGRFYRKVYNFSVLTRYFIYVAPLALAIAVPIIVGATVAPRARIGGVKIVWFFAWLEVVWVSLWVSKMLAHYIPFLFQFICGVVSAGTRKYALMLSALEIPLSLVGWAVTSLATFVPIMTLNPDQRSRGETSLKDWESIVKNILFACVFSTLILLGEKVLIQLLSISYHRKQFDDRIKDSKRNVHLVGLLYEASRKLFPEYSREFLEEDYLINDVLDLGERSNRNSMLPGHKRSGSATPMRLIQNVARVGDKVTAAFGNVAQEITGKKVFSPTASHSIVVQALEKKHSAEALARRLWMSFVLEGKDALTIDDIVDVLGHEREQEAHEAFEVLDVDGNGDISLEEMILRVTEFGRERQSIASSMHDVDQAINVLDNLLCTVVFVATIFIFIAWLNRNFTTTLATAGTALLSMSFVFATTAQEVLGSCIFLFVKHPFDVGDRVDITDTQYVVERMSLLYTVFRRVKDHKRTQVPNIVLNSLWIDNVSRSKAMREKILLYVDFGTTFEDLDLLKKEMTNFVRDKDNARDFQPDIDIEVTGLAEMNKMEVQIEIRHKSNWANEAIRAARRSKFMCALVLATRKVPIYGPGGGGPPAGHKANPTYSVTVTDDVARMNKEIFDEEADKKRLVPLMEQNKSRVDLPKVQSPDNTSTTTGAEAREASAVDHLVKRKVAVDPEDVLDHERELQVNKQRSNDVDSVRDILRRESTVGRRRAARNSGLQIPGADAMGGSRTIPTIAEPSPPEPVAATVSAPPRVSYFEDTPQAMPVASAAPHGWTTVTPLNYSHPTVSPAHQQTSQSTSPQTTQAQPVSSPGRYVPGNAFSQRAYAPPQISRQPVPGMPEMKNHLQGQSPSPPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS60</accession>
    <name>A0A1C1CS60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pre-rRNA processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_08050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS60"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08050"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06769"/>
    <dbReference type="eggNOG" id="ENOG502QZVV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5596576at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059065">
        <property type="entry name" value="Ig_Tag1-like_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059066">
        <property type="entry name" value="Ig_Tag1-like_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055011">
        <property type="entry name" value="Tag1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF3">
        <property type="entry name" value="PRE-RRNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26174">
        <property type="entry name" value="LEA-2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26150">
        <property type="entry name" value="LEA-2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26153">
        <property type="entry name" value="LEA-2L_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22786">
        <property type="entry name" value="Tag1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1 C-terminal" evidence="3">
        <location>
            <begin position="435"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fourth Ig-like" evidence="4">
        <location>
            <begin position="553"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fifth Ig-like" evidence="5">
        <location>
            <begin position="676"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT51315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="787" mass="86145" checksum="E13995D58DF0E398" modified="2016-11-02" version="1">MSSRQTSPQSSERTPLLSRPEDDARSNYSHQANGEVLPSISDSSETSRSKKQRKWPTIVALTVLCLAVVLICFGLTLPSVIEEYAKESVVFEPTRLSIDSFTSFGVRARVQGDFYMDASRVRNGATRRLGKFGTWIAREVKSGESEVHVYLPQYDNVLLGTVTIPPVQVNIRNHHYNHLDIFADLEPGDVDGVRRLAKDFMDHKLDQVIVNAVATVPVQSGLIKLGKQTVSQTLQFQGKDVPPVPQPDLHELRFAEYGMPGHPEGVKAMAVVSVMNHYPVKFDVPSLAFEVLLPDCKQDYLRLGTASTDIIHILPKQNISASVVGLVKQLPTSLTEVCPGSKSSPLDSFVGDYLAGRDTTVYIRGAEQDANTPAWIGEILQDTMVPFSLPGHPFDNLIKNFSLADVHFSLPDPMTESYPKLSAVVQVLVGLPAEMNVNMDVNRVKADGHVFYKGELLGRLDLSKWQAANATKVDGDLLIQSIVKDAPLEIQNDDLFSEVVQALVFGQGASLGVQATVDVDTSTALGEFVVRSIPAKGEIFVKPIRGGDFAMPQPEVKGLEIVDSTETSLTLQARVNATNPTEYSATIPYCNVSIYVNDTRVGYAWVSDQHIVPGPNNLTARASWETGKIGSEWLSQYISGYNTSLTIKSHPGSIPNFPDIKMEMTVPTPHIISRPLKETTMHLFSSTATFILVSPLAFYVTSIAASAYYNGSEVGTISYEYPFAIEPGENLTPRLPVEWGGNALGTIRDALGGTLKLDAKADVGVRMGRWQENLWFEGKGLGAKIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-12-14" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSB3</accession>
    <name>A0A1C1CSB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08967"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06707"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="277" mass="31210" checksum="4D993526D848B418" modified="2016-11-02" version="1">MPLQTVPEETVMDPNPTEEAGTETSQAHFAPGPTEREMNGLPIDSMVTGRMGLPLMWILDTVIDATEHSTSEYSRKKRETRTIINHARRVTTRLGVDEPIRIVALCTIVLDQARELRSCLQPGQAAIELAAEHIRAFERTRRRSDTAGSANNNGVPAILVQWADMNSSRLVAGLASFERQNRDFSRFGENVDRLMEFALLTLGIDADKPGRVQTLVVLEVRRGDRTWATTVLHISGAENGTTRRECYQDSSWTWDGDQNSSWSWSWFKRLGLKNTVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSV3</accession>
    <name>A0A1C1CSV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08407"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06524"/>
    <dbReference type="OrthoDB" id="4159995at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="537" mass="60049" checksum="BCF8B6905865D951" modified="2016-11-02" version="1">MAKGQKESQLTFILQGGPSGRISGVNLSDVNAHVARVQHQRKRGPASPLSSSPAPRRPLTAYERIGEKKQLQFLTHVFSNRGQGEHNVPPPVVLAGNSDPFASTTIAVTPLVNHLLIFTRDFILPANHGNESALYGGKIHMHRYWRDNVRGLDDGRADGYAYLARSAAILAKIKPENETVLLALHYIGKATSKLRESMLKREDSQAHMWEVYALLAAEVAAHNFKAAAVHGRMLARLLQPEGRTLKAEPRLLMGALFQDMTRACLWLTRPSFDLDRWDAEHLPEHIIDEIAPEARDSPSALPFYEDLAPSLPRSFAALVIGVREWHHALGMGMLNKSLATLKVFTNAAMKIMLLSGHFLTQYLDRVELWTLLPSPELLVDACLALAAAYWVRRAVHDRMDAGSKLEEAGSWAFDMSLVVAWRLRELDLKVEEQGQGLVKLGSEAAEDRLWWLFVGTMAERNVRLMPDCGDYKDYHGERFVRLAREMGLTEWADLEHVLRMYLFVEPMGRKTKKWFVANVNASVNVGADVIGGPGDHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTR3</accession>
    <name>A0A1C1CTR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09363"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="79" mass="8879" checksum="EF04C1775ED8946A" modified="2016-11-02" version="1">MILLKQLEHDYVGRSHNPRLREETTYWNALESRSTPTKDQYPGTLDVARLCGNAPNAELVKWPSLLAQNSAAPTKVSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU15</accession>
    <name>A0A1C1CU15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen permease regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Required for meiotic nuclear division protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_09264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU15"/>
    <dbReference type="STRING" id="86049.A0A1C1CU15"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09264"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06157"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0469">Meiosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="7">
        <location>
            <begin position="65"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="130" mass="14551" checksum="90E86B3B445F940D" modified="2016-11-02" version="1">MRTPAQQFKHNPKAASLVVSPQRASPEESRWLDYIASTMGPARTSSPPDLASSPGASNPSDIEAAEIQRYWSIFVKYFTGSEALERIPVREGLKRKLVWDTLVKMGLDLDGAVEDDKPDSKRVLVTIRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUG0</accession>
    <name>A0A1C1CUG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mpv17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_11379</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUG0"/>
    <dbReference type="STRING" id="86049.A0A1C1CUG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11379"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06013"/>
    <dbReference type="eggNOG" id="ENOG502SQ0T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="100"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="251" mass="28711" checksum="1C97C8BFEED5A4D8" modified="2016-11-02" version="1">MRSQSSVHLTTPPGMPNYKKGGWVRKLRPGKHLLEAWILSAVIVSISNVLAQFIDASREEDPFTFDLPRLLRFLCLDLITAPLNYKWQELLENTFPRHQHPQVSGEYESIPLEDRDEEKGSQADGMEGDDARAGESSAGPRRRRRNKTPQRLPKKNWKNIWTKWFIDCMTLGALFNTVGFLIIMGFLNGQPQNILANLRTRTMGIILNGYKIWPFANIVAQAFIPFERRIIFFATVALVWNIYLGLVAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUJ2</accession>
    <name>A0A1C1CUJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08895"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06025"/>
    <dbReference type="eggNOG" id="ENOG502SR9M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="312" mass="34797" checksum="90F68B1A3A43B1D7" modified="2016-11-02" version="1">MTSSTSNVLTPDLTPSHSITSSPSLPPTPDSRHLDIVIAHYNESLAWLSSHSNLASVYSKGKPPPDPSLYRETQALPNWGRESHTYLYHIVHNYDSLADVTLFLQGNIHDANDGTPAHTDLTLDEIVGMAKRLTDLPNLTACEDVQAQKETQGRVLPLGKVHTFSDWAGIKYLPSWVERRGKGLHLSKYTPEQFFNYLINGTADKTDARWTTPPNEIRWTQGALFAATRHAIQRRSREVYVRAYEYFHGLEDVNPEEGHYMERFWLCLLGAHNSVQQASPGSHIGKVKGSVGDGGSDNHGEVEEKGIFVLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUY0</accession>
    <name>A0A1C1CUY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sin3 binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUY0"/>
    <dbReference type="STRING" id="86049.A0A1C1CUY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08687"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05866"/>
    <dbReference type="eggNOG" id="ENOG502QW7S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5391991at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000432">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018818">
        <property type="entry name" value="Stb3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28164">
        <property type="entry name" value="PROTEIN STB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28164:SF1">
        <property type="entry name" value="PROTEIN STB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10330">
        <property type="entry name" value="Stb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="42183" checksum="3579B1E304E3FA57" modified="2016-11-02" version="1">MAPPTVSALGMALHGKSASVDIPKPRDAVKVRDNFTDVPAKTSSKKRPGMLPTPPNSISPNLPPRGHRRRDSSNHGPVSPKSAAVDSDIDLQNAPDKAQTTALSAEALDGLGDLDSAGAITPGMLAKHHLPDILLSHGPLAIRHIMGYLTTSVPGFSRITSAKARRLVVAALEGKGGEGAGRDGDVVFEKVGWGRWDARLKGQPARERRGSNITPPGSLPSSYSQPGLHVPTQRSWRTGSENLGTSYTGTSAVFSHSEMDYEDQDMLEHEADKMSLDGDEDGYVSSVAPEPLDEDLGDGDVTDEEDWASIGAAALRARSLPKSGRSVSGPGRLYQPIATYSYRPRYRSKTPADVARSAPVKQLPLNNSTTPFAFPTGAGVNDSQERAAIEALLSLGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV64</accession>
    <name>A0A1C1CV64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydropyrimidinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PYD2</name>
        <name evidence="4" type="ORF">CLCR_09914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="2">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV64"/>
    <dbReference type="STRING" id="86049.A0A1C1CV64"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09914"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03805"/>
    <dbReference type="eggNOG" id="KOG2584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000174">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF96">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="3">
        <location>
            <begin position="55"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="494" mass="53920" checksum="B9CBFA00E1F00FF6" modified="2016-11-02" version="1">MDGFDLLVINGLVVTASDTANYDIAIKDGKIALLAPPGVLGKGSAKKVIDAEGGYVMPGGVDTHVHLEEPALFGGKGRSSDNFETGTRSSICGGTTTIVAFAPQAKTIPSLLTVLEDTHARAKDNCYTDYSFHMLVGHPGEQALSEFPRLRELGISSLKIYMTYEALQLRDDQILDVLLASRQEGITTMIHAENGDVLNWMTKKLEERGLYAPKYHATSRPQIVETEATNRAIALAELMDAPILVVHVSSPSAAAHLRDAQTRGLPVYAETCPQYLFLTRADLDKPDFEGAKCVCSPPPRESAHDHDAIWLGLANGTFTVLSSDHCPFMYEDREKGKKSILSAEYPEGRFSGIPNGCPGIETRLALTLSANRLPLQKFVEVTATNAARLYGLYPQKGTILPGVSDADLTIWYPPGRLGSFKLTNSMLHHNVDYTPFEGMELNQWPRWTILRGQVVWDRDGGGLVGTKGYGQFVKRGKSTLPGPRKSGDWDVSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVJ7</accession>
    <name>A0A1C1CVJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_10760</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVJ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CVJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10760"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03861"/>
    <dbReference type="eggNOG" id="KOG4077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT52465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="164" mass="18499" checksum="CB5419B96170AA6A" modified="2016-11-02" version="1">MASLAVFRLTARPATSTLFRPCIRSLRRAPAIAQNVSARASFSSSAIQRSAGHEDETFEEFSARYEKEFDAVQDVFELQRNLNNAFAYDLVPSPGVVTAALKAARRVNDYPTAVRIFEGIKAKVENAQQYQEYLDELKPLREELGINLKEDLYPDNSDSPYYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVV1</accession>
    <name>A0A1C1CVV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10937"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04048"/>
    <dbReference type="OrthoDB" id="10357649at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="157" mass="16839" checksum="887E9EC19B8EC219" modified="2016-11-02" version="1">MAPVNSTLVVTSNSSLTIEQKKSILRTRIIAGCIGLGFTVLAFAIFLYTRIRHARERRKNAAIGLADQVPPEDSSASDVPLIQSERPKGTKYHGDSGDETGPTPNQGLLGTPENTANGDWDEVQRPASIASFTSPQIRYEEYQSQTAGPIGIGVVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVX4</accession>
    <name>A0A1C1CVX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD repeat domain-containing protein 83</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">wdr83</name>
        <name evidence="12" type="ORF">CLCR_10505</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVX4"/>
    <dbReference type="STRING" id="86049.A0A1C1CVX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10505"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04082"/>
    <dbReference type="eggNOG" id="KOG0316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="71437at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="11">
        <location>
            <begin position="93"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="115"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT52704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="334" mass="35298" checksum="480277B700B649A0" modified="2016-11-02" version="1">MTRPALPSSLINTLASHTGPINALTFSSLGGTYILTGSSDRQVHLSRTEPSGSSSSSAQPSRPIQKYAAHGYPILDIAVAADNQTFASVGGDRSVFLWDVQNNEGTSRRFGSNTSQGHTSRITCVAFAGEGDSVLVSGSDDTSVRMWDVKSRDGRPLMVLEEAKDGISALVVPDAGHEVVAGSIDGRVRAYDIRTGKVTVDVMPGAVTSLDISSDGKTLLVTCLDGRIRMMDRSDGTCLRAFPPEDEAAYKNESLRLKSCFGMNGGLVLSGSETDGDVRAWDVLSGNNVGRVQLSPTGKVISVVKWREGSQAQRRQALWAGGGADGTVKIYAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW09</accession>
    <name>A0A1C1CW09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW09"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10676"/>
    <dbReference type="OrthoDB" id="10472238at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="275" mass="32285" checksum="6AE6B4D055227B4D" modified="2016-11-02" version="1">MESGSRITTQSGRFFSQQGPTEDDKVADQRHLDRLQIVREVQEEAACLAAKTTGLSALWLGDQDRHCSACESRVYREARFSEEVDHITRMWVQEQSRHLKTSNNLEHLHALLEAPNAAYRYVSGLAEQDTTLGLLSLPEQFHREYELRQRSRKLQTEGERLDFRRARLRQKARQLIISIRKYEDFGRRLRTEMDRYSDWLELRAHTLQRNYERYCEIMAERSQPPLVLYESVEDLARAKEDFLVAASEREQAAREGKESAYLDGRPDMLEDLYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW65</accession>
    <name>A0A1C1CW65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW65"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11097"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="82" mass="9002" checksum="8696A5639AE47740" modified="2016-11-02" version="1">MHSKLAPPAFSSPFSPGNFKMVVAMRTISVSNQIAVPHATPVNTAELDMLVSFGDFRSQTSVLALRVVVENQTVESRSVRQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWG1</accession>
    <name>A0A1C1CWG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative aromatic amino acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_09824</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWG1"/>
    <dbReference type="STRING" id="86049.A0A1C1CWG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09824"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04126"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF1">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="107"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="628" mass="70634" checksum="AACDECE856A6EF5F" modified="2016-11-02" version="1">MANAMEKPAPRDMSHHYSRVTNRRIASQMKHFYKYFAIPGIGNLAGGLPNPGYFPYDTLEAQTAVPDRFKPTPNKPVDPPASSEPPTASRVLVPHDSAEPNVLRKIDLTTALQYGTAQGYPPLYTFIRSFAQANLHPNVPYKGGPEVILTCGSTDGFSKTIECFSNVWDEERDWIREREGILCEEFAYMNAIQAAQPRGLNVVPVAIDDEGMLAYGKGGLQDVLVKWDKNKGKRPHLMYTVTMGQNPTSGLLSLKRRKEIYALCQKYDIIIVEDDPYWYLQYPSANKLSLETRGKVISENFPTSSHNYNTNSGGKSSGFPFLDSLVPSYLSVDVDGRVVRLDTFSKTVAPGCRLGWITAQPEVVERILRITETSTQQPSGFVQSMIAELIMGPSANGDAGKGGSKDGSGWKVDGWVRWLEGLRGNYERRMQLMASTLEEGKHLIQDSKPRSNAFAPDDVEYEVVHKTQMYDFVYPMAGMFLWLHARFETHPLFNEVDHERLYRALWILLTTEPYRVLVAPGQMFSPTPEIAKQKGWQYYRLCFAAVDEDLLKKHSDHIVAAFRHFWTIEDVKEIDRLLEEDDEALGARLGELSVQDQVSTNKSSSPLSKRPTLTEILQSSFAANPIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWK0</accession>
    <name>A0A1C1CWK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTPase activating protein (BUD2/CLA2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_09459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWK0"/>
    <dbReference type="STRING" id="86049.A0A1C1CWK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09459"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04182"/>
    <dbReference type="eggNOG" id="KOG3508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05137">
        <property type="entry name" value="RasGAP_CLA2_BUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="726"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1085"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1085"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1222"/>
            <end position="1236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1236" mass="138541" checksum="C97223686CC28D88" modified="2016-11-02" version="1">MKPHDRQEPASVASQRKARPQLMQQRRSSRQASSRDRHGMVFEQTEQHTIRAVTPDLIIPRADSFDAHPIQSPVLQPTRTRHSQRRRETSASASNNEEDSAAEKRRRRAQTRTSTNEEPTLDASPGSFITKTRKRLGSIATGLPLPVMPPEEAHAHGSIGFPSVVQSPELMDQHNPPRTPRRPFSPDNSLGMSASSLRSPNLLDIDSSKILHLMKTTCGRMHGILFFRQLHTTAWASGYCAINVAPGSLVCQTKGEVHQSRTLIPDLRGCTVRTHYDHETQSTYLSVIIASSGTGYQLRPPVPETFDSWLAALLCWQPLRPKGIHNKMTKPQSISMTEKKPVSQRRLSDLTNPKATAIVKVGKMLLWDGPLPSGSQLEASPSSLGRSMTEENYLWRRVSCTLHENGTFRLLSEVDNRVLSVTPLSQLSRCAIQRLDESVLRMPHCIAVYPQYRIETPAVRLSRPMVLCLESNVALEAWFVLLRALTVPELYGPEHFSAEDSQIQPQPSSNGNNIPTQGMFRIERSLSIKLTEAKFAQRSAPKDTFDHSKAKGKSAKADQSKEGVYAEIMLGKDLRARTTTKQNVSPAFWAEEFNLVDIPAALSKITVAVKLGNPAEKEWTMVADSLYDISADAGYLSGLGGLEISSHDPIFGRVDISIDELEHTGTIDQWWPLLDNNDHSVGQILAKLSLRETVILMEEEYKELSAMLNTYGNGLTTQIAHLLGPELRELSDILLDIFQATGAANEWIKNLVEEEIDGTNRDMPPMRMRFSGRIHSNDSYESAEQREMLVRDLSRSATMEANLLFRGNSLVTKALDAHMRRLGKDYMEEVLGEKLRKIVERDPDCEVDPNRVRSQEQLDKNWANLIFLSSEVWKSIYVSASRCPMDLRVIFRHVRSCAEDRYGSFIRTVKYTSVSGFLFLRFFCPAILNPKLHGLIHDHPPDRTKRTFTLIAKSLNVLASLGRFGTKEPWMEPMNKFLAASTNQFRSFIDEICGVSSSQIASARLEPQYAAPNQIRSRLPALSREGLPSLPFLLDHAKLLAQMVDLWTTHAPENIGDVTDDEAVHAFHAECVKLSRKTKECLKAAEQAERPDERSEHTWQRLVTDQQKSIPNNSQLFDESLTRSNRNSSITALPPTADTVTEQEYRDPEPSPVVGGEGDTTPSSSQSQWDRRIPFPHRAPESVSSTEGGDMVDETRRTQPSSRDGPSKLFHLMSSSSRRRGRAGERGHADDEGHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWT1</accession>
    <name>A0A1C1CWT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10914"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04346"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="167" mass="18980" checksum="73B65B20024CD244" modified="2016-11-02" version="1">MGPVCVCLFQRPLRFFTQFPQSWLDGVTGLDHPTITNRLQKIMDDINLTMQRWKMQRTDSYSDYHAEVDTNNPRRILAGSPRVYVPNGMWSQARSISPQPKYSDDSMVFSSVSDSADRYGVSGTNTGNYDEETVLRIPLVRILLGEDTAGWDADDEVVYDHPRGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX23</accession>
    <name>A0A1C1CX23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX23"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10076"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00091"/>
    <dbReference type="OrthoDB" id="4160898at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="473" mass="52764" checksum="61C196CE7E1EAC6C" modified="2016-11-02" version="1">MEIYGSITGCVLLMSDRPLTRCQREYFSPGCPSKGINEIPSHLNPDFSPFSPFNVTLSPEIRISAHPIYASLLSARVSPPELDHHATPPTDFIRVHIRGQHCFDQKLAEQKREQDDIYVLVPIAPTISAPSSILQPGDSSSISLRHSIHARRLLLPQQPPTNPSIDSDAVIDLQQVVAFLPHHEQVIVHLVQLDKRPGHQRGTTGPSLGTQSGRKSGPSLQCLSPGTKHRSCMVHRLLKMVTQAIETGASPPPRGATKLWSKMAYVVGLGCCMNARHPRPASTPTSRSPLEEIKTGDINWSASTLGIERDLPPTLGAEAIRSDPSMPDVRDIPLSSMEFFHAPSPALPPPVASPQSRPRREQRRGIDSPVVTVTDHDIATGTTPSTGECQRERQERHHHQGRRRRRQSPQRDRDRETVGAGRAWSQIDPLYGMYQREREQQVQRDRQTQTQSRNRYADIRGFEFLSYGGWIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY75</accession>
    <name>A0A1C1CY75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY75"/>
    <dbReference type="STRING" id="86049.A0A1C1CY75"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09586"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00458"/>
    <dbReference type="eggNOG" id="ENOG502R3N6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3199516at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="43"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="881" mass="98865" checksum="11A38688F38D8B7F" modified="2016-11-02" version="1">MEAPVEVEEASEHLKAAGTEGLLEKHLQGKKQEWDVITAHKEPLRLLDLPMDILQVILKELTHTNDLTSLALTHSALHALVIPHIYARFDIVWPDANATFENRMGVDALTYGLATLVMAQDVFGEAPYQSQHAHQCQQCGHYNQPVQHQPVTTSKNIRRGNHFAQFTRKFSLGNGPADWVQEYLITKEGGKMLGTLVALAVGRMRNLETFIWDMPTGVLRDVWMALASLGNRHDGQACRLERVWVRWHDNQDQGPLASPPPPGALPGAQNANMPYILAGPANSLFQIPPYPRVEFPTFSILPPLKSLSVLDIDELPYAEEMSVLIDRSLDRLTELRVGMAAHAQYDMWARPSEERPPVLPSLVPGMTEQTPRPGGMLGILVHRFCDAFSHHKQSRPSLNLERQRDPLMEDVTVEGTRELEREDDAEELVPASDINQLGVLMSAYSIHDDELDMIPAPTPKQRTVTNLSNTTRQDHPNHSSDSFSDSNKEGRSARKLTLETLELERVYLSIAVLSKAVDWSRLTTLTLLNCRNHEQLWKALRKRFTPSSRRRVSSTPYRTSSNGMSSMVLRSQTSTPSTPAPPAADYALRLRRLHTDTVSPSLIAFIKDTLAPDSLEWLFLQENTAYKSPVSIDMIYKGAVRRHRSSLTKLLIDSTFRTEDSERPNTNWRRWVFNRDLITCITSGKMKLRELSMSIDYKDWHYFLRRLPNATTLRSLHIAHIAEHVNGTVHSREAALQVLDIVALRPELELCYLGIQGQCFEILEYASPRKCAASSGGDFSADDIGPDGDGMAPNHTDTHNAAADNHHDDSHDDEAGDHADGNEDSDFDAVSDGADDLSDDGEGNQSGDERGSGAHRPTWRLREILFYDDKISIFKARHGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYA1</accession>
    <name>A0A1C1CYA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein dopey</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_09429</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYA1"/>
    <dbReference type="STRING" id="86049.A0A1C1CYA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09429"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00479"/>
    <dbReference type="eggNOG" id="KOG3613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="7">
        <location>
            <begin position="5"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="8">
        <location>
            <begin position="352"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="9">
        <location>
            <begin position="1196"/>
            <end position="1651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT53513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1671" mass="186734" checksum="685EEB40476B96C4" modified="2016-11-02" version="1">MTDAKAVRRYNAGVERALGLWDATNEWADYIAFLSRLVKALQASPPGAEVPFKPTLAKYLALCLKPSLPSGVHQKALEVYSLVFTLLGTERLSQDLPVWLPGVSHTLTFATLTTRPLFLALYDDHLLHLSSRALRPALRAIILSLLPGIEEENSEDFDRTLSTINRVRQGFAEDGTEEFFWQSLFLASITSTSKRPGALVYLTRELPSLGSAASQSSDGAEHSGRQGETLHEAIRAVTTPEPGLLIRCFATGLQDEQPLVQRGFLDLLVSHLPLDAPVLQTLVSPNDLDILVAAAMSVVLRRDMSLNRRLWSWFLGKEDKREGSTDVVPQSTVEPTAPTQLKLHPKAPRHDYFATFGLDSVIRSLDKMLRSEALSPIERARPFRIMLSLMDRWVIGKLPVEALFVPAMQDLQRYQATAPSQSSFDEVYRSANVFFDAIEPQLITSQLFRLLVQGDLELLEFILANFNLQEEEMTTIHLPMLCLAISEILLREEHSELLGRDAAQPLRIAKLLEVLLSLLPPHTASNALQPSGNMEQAGWLSRLNGLYEHSSYVKKAIFETIPPAIAAEILLRNIALIILECLSHPNDHELLGPLTNSFTKAMARTSNFRLLRELRFGDRLHHLLKASSEGPRSKYESIKTVARIVDTLQAFDPSEETLTQTHLLQLIPELLSQLWKLLLPSTPQFHVDAVEQIWNLRMLSHELLLVDSKIAELMCEDDTSAARLEDRIARFSTLWAHTRFPEVTIELFSSVRGIQEDELPWATLRQPVLAIIDGVDASQANDRRRLWLNNLPSIGPIFRIIYAESTHSVDGQISLLGLHRLRKVVTLAKQSAAQRNEFFGQASFSDMMLDICTEHISLGHSEKEIFTTTLSILCLILEEVELRGDHNLIRLLMQLLSQVVPDSPSQEEILDVLQIIFSKPNIGSPPGNLIQVLISGISSKGIDSTIDKWVTLLCNTIPLYSTQTLFANMLRLTACFCDRVKDYFALMRRLYDRPEAAAQINGAKPIPAAKHPERSITNLLAGLEYVLARAHTHLVDQVSGADEASLNGAEKTQLRSMANNRLTVILCMQDTIRLCGQIWVWRISKRTLNSAPDGKSFAYISSRLRTRTRRILEHLADAEPQECLETLMGMWVDATRRDSGQDVTLNLMQSLDGARPKFMMPATFNAVYNRTNPAALDQSQKSSLSVDVSALELMAFLIAYTSALEDDLLEEIWTDCTAFLREVLANPMPHRQILLKLLEFVAVLCQKMENTNFGEVLKMRRELSDLCARLFTAIFTIRPAGLDSTSQAIPESGSAKAVTDTRPRSPLEAGGAIQVLCEALPIISNALGDQDRLTVTLSGIATHVIGPALRSKQFPQTVSINLLQLVLLLAKSQPNNKTWRKDVSEAMNDNKFFQSPPALAEAGWLPVLKQLWLTDKSLMPELVSRLNPPTTAGIMFGVGASAARTEADRKTQLNLRRIALLLLAADVDAFVPDLIQIIRRVEELLTATSSSSPSSSTRGDIYLVLRAITLTFTQTHLVSIWPIVDVELRDLFISMQQTGEPTYTSFSQLQGAKLLDLLLLLKPEEFQLHEWLFVTDTVDAVYPPQDFQSTAISDQIVSKGSHDIELPTVSEAEARKPWLCTDMTRTTEDPQTLLRPFFRQLSIHAFEDTYSLQPADLEACRKDLLADLFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYC2</accession>
    <name>A0A1C1CYC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_09547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09547"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00395"/>
    <dbReference type="OrthoDB" id="4116881at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="546"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="670"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="790"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="830"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="898"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="949"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="960" mass="107369" checksum="4D1427B82EE5B54E" modified="2016-11-02" version="1">MLPSSALPKYQEMMRQEGSDLTRRVQPPGQINGVVSGGGRRVYTSHDTRRNELHDRPTAHHLSERAQLMVRLPDLPDIRRTLFEIPSGQLQAISRSDRLYRSTCDSHKSWVQKESKSLTSHYIRCLGRGPDANLLTWPELKAEARKLMGSTLYQQIIQWTRQQPNLNFKLGDGTELVDRQLSFLTIRMNHHDPIPHTASIQVQTERTRKHRIVAMLQQRQNLREWTIAVAEQARLCVGQRYRKELDHVLDFWTGKVESLEEFTERNRKENTGLRSDMLPVGAQPAGSTAQVQEQEQPQVQSPMQAQVHDQSSQSEVSARRQEQQVDYTPLLERAQQKARIPTSLHNQSQVEALNQPQTQPQSLRSIQTQGQKQEHVDTETTGSIRAYGHHHVQANAQMTDSAQARAQATEPIQLKACRDVNIISPAAGRTPARDEAQEEVCNQSSEPEQLHTITQFQAQVQIAASSCEEVSTGASNPVPKENVVHEYEQHEDLGQIQQQGLPRAYSQKAVLAPELVSLTAPSAAPVQIQAHVPLHVEEMSPLQAQEEIQQHTQKLSPSRAQEEIQQHTQKLSPVHAPLTQPKPAEAPEESLFQWVIQAGLQHSLQGDSQGSLAAQNAAPLTSRDCIQDKVTARVQEQPQQAPQAEGQLSSEQQNPDGMLVEGQVHETVPCEERDQTQAEQSESQEAQLHAAKLDTIENPVVATDEEVVEQGSQPPAQLSHAQRVEDDNVDTTRPSDSGPQEEKTAKAPDEKCHHCTKSKLRCNGERPCQFCVKYRKCCYDLNARPARNMRGRNLKTASRSAAKDGKRQAAAPETGDEQPPRQPKPLEEVLSTQQESAGQSQEATTTNNVDATGLDTHLSDDDGGGGGDTERLESIAASETLHPAQNQGEHHGYDTKQQRQQRQQQQQQQQQQTQSHPTKAARKPKQETPKARNVTTRLAGQKEAEQGRRSLRTMAHRSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYC3</accession>
    <name>A0A1C1CYC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate pyruvate transaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamic--alanine transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamic--pyruvic transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ALT1</name>
        <name evidence="12" type="ORF">CLCR_09841</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYC3"/>
    <dbReference type="STRING" id="86049.A0A1C1CYC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09841"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00505"/>
    <dbReference type="eggNOG" id="KOG0258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000151">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="183"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT53544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="572" mass="63271" checksum="0712EF8D991D3EAB" modified="2016-11-02" version="1">MATRTGSMSRTLSVFVRAEYLSSELAIACRALGLANTTRSSRHPPRRNALQASSRPPPSHIQSSGRRNMSSTPRLRSLNIDNINPHVKEAKYAVRGELAIKSEELRVQLKRGDPPTPPEKPLPFDTVISANIGNPQQLDQKPITFFRQVLALLEYPALLQNEEVLKSSLGYKQDAIDRARWLLKEVQSVGAYSQSAGAPGIRQSVANFIERRDGFPSHKDHIYLSAGASSGVNTLLHIICAKPETGVLVPIPQYPLYTATLTVLNARCVPYYLDESQAWSTELATIREAYDKAVSEGTDVRAIVIINPGNPTGASLPEKDVEETIKFAAEKNLVIMADEVYQTNVFVGEFHSFKGVLRKLQQKEPGKYDNVELASLNSVSKGMVGECGHRAGYFELVGFDPEVQAQIYKFISIMLCPPVIGQCLLEMVVNPPKPGDPSFDLYDQEYNGVKNGLKERATALYEAFKQMEGVEVGEPQTALDHVLTKAAQGSMYLFPTITVPPKAVEAAKEAERSPDEFYCLRLLDETGICVVPGSGFGQKPGTLHLRTTFLAPGTDWVGRWTKFHEKFMDKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYY7</accession>
    <name>A0A1C1CYY7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="9">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rdr1</name>
        <name evidence="12" type="ORF">CLCR_09444</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="9"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYY7"/>
    <dbReference type="STRING" id="86049.A0A1C1CYY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09444"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00630"/>
    <dbReference type="eggNOG" id="KOG0988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058752">
        <property type="entry name" value="RDRP_C_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26253">
        <property type="entry name" value="RdRP_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9 12" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="19"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1137"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1258"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1137"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1154"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1311"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1403"/>
            <end position="1412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT53686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1412" mass="159557" checksum="A8E16CF6986EB457" modified="2016-11-02" version="1">MDLARQTRRDEEWRTWPSVKAYISNLPRGVTTYDIHRNFSRFGNVEFIRMEETRQGNFAGQAIIVFKPPPPGRAPWDEQFINKIHFHSRRNEGEPLPRIKVRYEARPPNRFVESPVRSGVKYDPEVTLYGSAIDFGYLSRPECMVVKAQRQNSRGDAVRLRLNLTRLEMEVHFPVVIHSRGRAIERAYRFSVALDEQFSLCEVHSNGSTALIIHLNNTPWYSRQLKEAMGLSHDDNSSKWSSDDTWSRQTDIVDEKETFQKINDTPVSVQKLHNSIDIARWTTFRVTIRPDIDRDQNSLGQFLTALADFNIRVSRDSSFLVVIGQESPAPFWDFVDGTGSQSWSEELLLPRRLDFDLRYQLEVCISKRWLNEFSLTREFLQKLSDMPTKRAKQMLIHVDLHQQRVYDPMSIFTDLRYTKPVLARAPPANCAEIYSATVTATGVVFHTPSVEITNRIVRRYSSVSNHFLRVRFEDDPYRGQTRLWPATNGKMKLVFDRVRRTMKHGIVLGGRRYEFLAWGNSQIREHGAYFFAASQHPRITVDDIRRDMGIFDHEKVVAKRAARMGQCFATTTPFKILNRDSHSKEADIPDIKNGKYNFTDGVGKISRLTALHIKNKLKLSGEEPPSAFQFRLGGCKGVLALDPTLTNSDVKIRPSQRKFDSGSNELEIIRVSEFWRPFLNRQLILVLSALGVPDVVFLRMQQKCIEDLDAAMRDDTVAVRALRENVDPNLMTPNIAAMIEAGFSQLDEPFVASIVRLWRAWMLKSLKEKAKIPVSQGAFVLGVVDETGTLRGHINDLQPGPNASREEREKALPEVFIQYTDPQKNVRCLYEGVCIIARNPSLHRGDIRVVRAVNCAPLRHMCDVLVMPSVGDRDLPSMCSGGDLDGDDYIVIWDPELLPKEWNAEPFHYNAPEPVRKENVSIDDIINFFYDYMQNDYLGRIAHAHLAAADCLPDGIDSEQCLKLVGLHSMAVDYPKTGVPALMTRDLERSQWPHFMEKKRSGVYRSTKILGRLYDAVGKAKFEPHLLGDFDERILIHAPQEEVIGFVRSLKESYDESMRRIMAQHQIASEFEVWSTFVLHHSKASKDYKFHEEIGQHAKTLKDQYYEAFREEAGGHDLAKLRPYAIAAYHITHEEYQKARKREEGHGSEDEDGSALSAESSGSVSSASTSAAGVPFISFPWVLQETLQQVAKNTVIHEDGGALQVNLSPTSVQNDKEDGVLEPGRALCRWTHNGDHLQDPYVAVPIDAEVRQDEFMAVPNHGPLDPAGLDSSPSPAQRASLKDVVPTKPPTAAELGHENDLSPSGLRLVASSNMPSVVSSGGSSSHTSPDDARPPWSVVARSHGRSADIASLSGLMPTEEVQSSSPVKLTDAHHTQSKGNESRAFQDPGSMAEGHIHALAKDPDDDDDDFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYZ2</accession>
    <name>A0A1C1CYZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_09554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYZ2"/>
    <dbReference type="STRING" id="86049.A0A1C1CYZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09554"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00695"/>
    <dbReference type="eggNOG" id="ENOG502RS3T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5392646at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048401">
        <property type="entry name" value="SLS1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048400">
        <property type="entry name" value="SLS1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20778">
        <property type="entry name" value="SLS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20776">
        <property type="entry name" value="SLS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLS1 N-terminal" evidence="2">
        <location>
            <begin position="141"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="SLS1 C-terminal" evidence="3">
        <location>
            <begin position="456"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="893"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="945" mass="104894" checksum="7D891238870E1CC9" modified="2016-11-02" version="1">MLARGPKSVYVCLRCQRNLLGDNFNHPARVLRRWQSAAPSRAALDDIDYGDDSNSTSVHQPQDESLSRPRPRGKRQFWRKWKPDPTAQLGVNSLGKPAEVILLPSRDRKITQVPKGDRTERAGTTLQESLDSENVPLSGAKLAENIEQIRLLVGKMRGQLEKHEWKTLKRNLKTGFQTSQLKKYIRLRKGDHGPPPELRRNQSKDDIIRYLAEEIWGFITPARDEIPTLPDKTGKKVKFSFNLDGQAKLEHLLTHPTQPLKSIAEEHDVQIDVYPSQSRVRTTGYKHDANRALQKLVRYAKDLALVVIPLQGPLGLLHRNRAGEDYADAYLKSLRRKYQGLTIARDKEHITLVHLNNPRAADQARREILLSAPLKDDTQQPIVWPDVDELTTSLQPVPGSAERPVMLHQYQWLRLVSSGVTPQTVGNPLFRRILESLRDALNPVVTLGKAGSRQELYCDLSAKFGHALVQEVPPPVDVENKVTLENEGDLGAENEPEQADLLGKPSSEAGCAEASDTRDFRMKKSTLGVAGPATEAPLQVQAVAEDAGKAEALAPSAPSESHERRLFVGGAPFLAHHLARMDPWPEQSSGDIDVSARAILRLEVSPVSTAGLNESPRFEIFVTAGEEADGKRSVLSIARISAIHQEDHFTVLCPRNDVDVAFTLQLKRDLAYPGSVDTPVSQSLMNAFRSYIGHVQSTGSSDWVFLPFVTLPIHHTLMNTHEHVQHATAKKSKTARQKRRRSAQADVKLEYLLRTVDVVDVDSRTLSLRSPSAPARMKETETPTRTQPHSSVAHFCLDHITYTGADATRQELRLAQSPVLHPPTLSAPQPHLPSFVGAALSLAGRLSDNPLKPEYPARQELEFEPLPEDGMEVPGEGKDTESATKSDPGDKAKPKKRKAVKKAQQSKHPAKSKSKSKLKSKPKSRMNIKPAENTKPKTKTKGSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ69</accession>
    <name>A0A1C1CZ69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ69"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10503"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00764"/>
    <dbReference type="eggNOG" id="ENOG502SYBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3938221at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037738">
        <property type="entry name" value="Ecm13-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826:SF1">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="335" mass="35793" checksum="6C8590175A62404C" modified="2016-11-02" version="1">MSRRAFTTSSTYTLAHTAQCKLKLAANRPDRNLRFVLGHAFTLDNLMLRIVEIENKSAKSLFEEGKAPSNHGADEHYDCTAAKPVAAEPDPHYDCAAAAAQPDPAKPAGNDGRGRRISFQDNNARPSSIGTAGVASSNTNGNGTSSPARRRSPPPVSISPSKYLSDGDEDGDDTSSDDYEDPESYLYNCEAGAPEPEKPAVRRRPVHDAYSDEEDAALDLADDELDDDLGGLSLTRFQSASAQPPRMVRSDSSSSEEDLGDEPVTPPQLPADVDVRDIISGEKDDELEGLYESVRGCGCHGHRGDPDLGRKAHGVWDIPVEKAGGKHLAVVAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZD4</accession>
    <name>A0A1C1CZD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-protein ligase E3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_09507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZD4"/>
    <dbReference type="STRING" id="86049.A0A1C1CZD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09507"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00801"/>
    <dbReference type="eggNOG" id="KOG1008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21720">
        <property type="entry name" value="MIOS_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="6">
        <location>
            <begin position="481"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="5">
        <location>
            <begin position="1025"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="858"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="942"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="858"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="966"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT53882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1072" mass="118870" checksum="4DFDE44B86BDA2B1" modified="2016-11-02" version="1">METAIRFSQNSLPGREQRFLYVDVVGKTFRLCNITGHAKEGLQYETIHTTTKVPAFRAFDWHPSNEDLVVVGQAGGEATLLNIAEGHQDSLSFQVRSQRSCNAVALNTQNLLAAGLDKVRTDFCLNIWDFNQRMPAPGSKGFSKNYSDPLHKLASGEPITSLKFFQDDPSLLVAGVKGQFVRLYDLREPLVGNGLQFATRCVYNLAIDWLDENYFASCYPTSDPSICVWDRRMISRVNTPHMGFQHNENRPPEVSLELKNAIQSPGTIWSLRFSKAQRGCLGVLSSTGNLRVYSLGKDFSETSRVEQNEGHDMSWETSQPQDIYLDRTQDIAKQYSDPSTPMEEKSRIVSFDFLTSTTKSKRPKILALDGHGRVKLTSPSPVPTPTTLAPPGFLCRGTSSTQMMSIESAETGTTLDQVRRRAQPRNTLKKTFRQSRQTKTAADGKRMSSLDDQAWHADLGFYETDVPFSDLLILIAAQRLRCEAGYLLNPTQNKAVVSDSHWLQSFWAWVERGVRISKNGNMAQDNLDLSFIGVYSLWMEIIDLKNRTLGPSSNKLGRIIENLVRRLSVPNVNSIATEYAANRQLCLHSAGLAWSSEELEVMVKRLVTKNQHTKAAALALFAMDRKLAYKALRNKTANQSHKMLAMAIAGAFKRAKAGDSGTVTGDESDEEDDWAATIASLADELTDPYARAILAYVKTGDWSNVVAEESLPLKYRVCVVLRHYDDSKLTQYIAQATKDAVASGDIEGVILTGTATQASFDLMSNYVQRFGDLQTAVLALCPAVPRYLNDEAVIRKFTAWKDAYKHMMNSWNLKFHRVRFDIACQNAAKDESGRPLIPPAKQQVRLVCQYCSQSLAHQAGTSGETSPGSKTIDTPRHPLRKEKAAAIGTVCPKCERHLPRCGVCDMWLGVPDESYLPWYGTIHASKHDLGQASLDLSASVSGSVQTTLGPDTSVRGGLKGTASPRPKNSPQRQSKTSATDSSTRTAVPVGSVADLGTDPIPDIVLEQSMITIAETDLEAQKAEEDRKWDIAMSRFTVLCVKCSHGCHAAHARMWFEKHRVCPVPECRCLCNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZS3</accession>
    <name>A0A1C1CZS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11428"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="107" mass="12778" checksum="3345EE5E557F2256" modified="2016-11-02" version="1">MHTEFLGKEPGWPTCPDCGEGHDPCEPSLGDQTPFKVERKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKMMMMIKQTNKHTRGQTRYIPVVGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZU1</accession>
    <name>A0A1C1CZU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10981"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00925"/>
    <dbReference type="OrthoDB" id="4158649at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="141" mass="15992" checksum="8BEFC72A4984311A" modified="2016-11-02" version="1">MCFKYKCDGCKRGKYDYCREYRENYEGGRRWCNVEEEQPWGHKLKRCHTCITVVGAIKELNALVFREPWLVTEGVAGAPQKEAWELEGEDGAGVEEEDAGTDPLDGLTAGERAKRRDAAMEAVMRRWGLMAAEQAVETEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D027</accession>
    <name>A0A1C1D027_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">15-hydroxyprostaglandin dehydrogenase [NAD(+)]</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D027"/>
    <dbReference type="STRING" id="86049.A0A1C1D027"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10476"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00958"/>
    <dbReference type="eggNOG" id="KOG4169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38229" checksum="76AA8615F0E1AA63" modified="2016-11-02" version="1">MIDKPVMVKTAIVTGAASGMGLALTRHLLARGQDSSSKVHWRVVLADVNEAAYDEVRTTLDQERHIFVRTDVSQFEDQLALFKRAFEWSGGRIDFFANNAGIPDRQPLLGWLGRPEDVEKEDPTEPDLSCIDVDLKAVFYGLRCFVHFTRKTRNLLGQETVQTMDKVGIHGGDAMIGVAAAAAAAHDFHPTMVVTASMAGQYPFYVLPTYTAAKHGCVGLVRAAAPTLFEDEGMTLNAILPSTTRTKIIPTPILEQWPEENFTPLETVVRAFEELIDADGRVVPDGLSDGQDGIVKNGCCVEASTNRLFYRDPVPFPSQVQEWVGQQSKRDGILGTFMSNVMNSREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0C3</accession>
    <name>A0A1C1D0C3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Low temperature requirement protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0C3"/>
    <dbReference type="STRING" id="86049.A0A1C1D0C3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00278"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10200"/>
    <dbReference type="eggNOG" id="ENOG502RZXZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840:SF1">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="42679" checksum="0B27DD4841D9FA50" modified="2016-11-02" version="1">MTELKERRYLIRKPRALQYFHRGQFKRELEKERVAGRFELFLDLLYVAIIANFSDDLTEKPTGANLVKFILIFAPAWHAWADAKENANNYYNDDVLQRTGVLWIMALLVVYGNNAVYVAEDPAAMRLTVATYMVLRFSQICFYALYSIASHHHRTQNRAYFLMILVGLCIWIPLLFESISLRAKAGIAVVGILYEEATYVLTFGPWIARWLGLEYTTAVDIDHENDRHAAFTILVLGEFTYAILVGSPAEGAITLKTLRAVETLIIAFCFNSMYDYCDGGTESTHPIRRAVGSAFGWLLIHLPLSAGLMVGGHVCAATVPEDELNAGQRWLWGGGLGLGTFCLFLIAAMYKDEDPPGFLLLSKACHSFELDKCAWTTDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0T8</accession>
    <name>A0A1C1D0T8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0T8"/>
    <dbReference type="STRING" id="86049.A0A1C1D0T8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00997"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01617"/>
    <dbReference type="OrthoDB" id="942095at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10715" checksum="7D037364C7626E32" modified="2016-11-02" version="1">MQAQRTKAELQQHKAKITDSSPTPTPNYLRTPRSVHLLLKHALTLPLSQFASTDLKTVGNYTLGKLIGKGSFGKVYLARHNLTNGSKVGFAIGRGQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0Y3</accession>
    <name>A0A1C1D0Y3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prenyltransferase alpha-alpha toroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0Y3"/>
    <dbReference type="STRING" id="86049.A0A1C1D0Y3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01002"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01655"/>
    <dbReference type="eggNOG" id="KOG0367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="2">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="103" mass="11432" checksum="B2F33358D932A916" modified="2016-11-02" version="1">MYQQILRHHHLVDIEAMRRYLLGKVTHIIGGFAKGPGELPGEWAPRQPNRVFADSGSLQATTDLLHSYLGLATLAIYNEPGLKAFDPTFCMSVDAVERLNNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D181</accession>
    <name>A0A1C1D181_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D181"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00928"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01726"/>
    <dbReference type="eggNOG" id="ENOG502T4PM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4135563at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27762" checksum="261FDA946D35F0E9" modified="2016-11-02" version="1">MALWTGFPARIGLKDTAESSPPPRRPLTCRAKSDDFERKLSCRFILPDEILDNALTRDHDPEPILLQMPYEILLAVYDSVAHAPSQVALALTCKRMARAARDVQLCLSPTSAKFAGFLPRAVFDVPELMTQLKPWMPPELRLCNHCLTNRPRHEQYWNTVAGCEVSNFWITKTGWEFRDASWHKQVHDICPACHASCSLSDFVDCDGCRALGRLGDVDWSRVSDSWRRRTEEELRAGRFATGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1E0</accession>
    <name>A0A1C1D1E0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1E0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03169"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="128" mass="14663" checksum="31881590C8668F91" modified="2016-11-02" version="1">MPTWAGFDQKSAKKVMTYQVYATNMQLPRISGLWAILYLRMSTGTFPWVEATLSDASSRAFSRRKILSCRPNYRREKHILMLDDMLQISPATIATAVPILRVRERKQCIFQDIFGHPGDIWPSSRGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1E9</accession>
    <name>A0A1C1D1E9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1E9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02993"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04800"/>
    <dbReference type="OrthoDB" id="10568550at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="352" mass="39537" checksum="DF6C1ADC129FAFAA" modified="2016-11-02" version="1">MSSLPVEVKCLKDVHGSSRISTSRQSSSIPLCCRARFFWRYQSPSVRATQGDLDGFISQRLSPDSFAREAIAALVRLNQIPHHNDHRQDNLLLPILNMGNSESGAGQTSIEDPALSESAPCKALPASTAEVMNSSESAPCKALPASTAEATTAPETECHDPAKGEKQKGDTSPSANEDNEKAAHADFKAWADDFFEREYTEHQWSAGAHISSSPISILVEPGEAVLRYLEPDEELLSESEESEDEQEPFMTWSNRTRLDAATSSNLSMRAMQWCMDKDKEYWGGKALPEHRQKSCWVKRSIGDRVERGRRIKWAEEMGRRYPGRYVPYPGRPVRAPRSWCRVEKGRRLQRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1Q8</accession>
    <name>A0A1C1D1Q8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1Q8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03208"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04723"/>
    <dbReference type="eggNOG" id="ENOG502SZN2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2532734at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="75" mass="8148" checksum="131C879260466C01" modified="2016-11-02" version="1">MATSDSAQDSVFDKVAKESDNSTASSHPSHQGKQEQAQAYHHQSKGPQLSDNLPEAKGKDELKAKAQEMNDHVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D249</accession>
    <name>A0A1C1D249_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_03164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMP46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D249"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03164"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04918"/>
    <dbReference type="eggNOG" id="ENOG502S4MH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="59229at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012882">
        <property type="entry name" value="Fmp46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071:SF1">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07955">
        <property type="entry name" value="DUF1687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="160" mass="17466" checksum="251F686F0E204948" modified="2016-11-02" version="1">MHVRAKTNASLSLTRWQGKTLDVITLFHRPSVQASVRAQTLLKQASAQAAQSATEDQASDHSHQNRTVTRTDPFDLEVTEAPPTPDQLRSIFEYVGSGRAGELVKGAASESDALRKVKEDGGLFIRPVTVDWNEGRAVIGDNDSEILKLLKMDKKSEAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D255</accession>
    <name>A0A1C1D255_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_11453</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D255"/>
    <dbReference type="STRING" id="86049.A0A1C1D255"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11453"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04927"/>
    <dbReference type="eggNOG" id="KOG3446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250268at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005822">
        <property type="entry name" value="NDUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT54836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="97" mass="10870" checksum="EBB59CDA89241A45" modified="2016-11-02" version="1">MATKYAFTQGLRELRFHLSNSGQGSDACRSFLRRAYPTMKHHNPNIPILIREATGIEPKVWARYGFGREKSESLAGLSDKEIEDKVTTLVKSDEGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D282</accession>
    <name>A0A1C1D282_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">argx</name>
        <name evidence="8" type="ORF">CLCR_02939</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D282"/>
    <dbReference type="STRING" id="86049.A0A1C1D282"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02939"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04976"/>
    <dbReference type="eggNOG" id="KOG1316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000025">
        <property type="entry name" value="Argininosuccinate lyase chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="6">
        <location>
            <begin position="16"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="7">
        <location>
            <begin position="375"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="467" mass="51942" checksum="568933669CE5E1AC" modified="2016-11-02" version="1">MADSGSKPQASMLWGGRFTGGLDPLMVSYNESIYFDRAIYAQDIKGSIAYARANAKIGILTQQEFEAIEKGFAQVLSEWKNDKFEIKPGVDEDIHTANERRLGEIIGTHIAGKLHTGRSRNDQVGTGMRLWLRDQLREVEQHLIALLRVTTSRAASEIAALMPGYTHLQRAQPIRWSHWLLSYGSVFTSDLERLREVIKRVNRSPLGSGALVGNPFGIDREAMAKELGFEGIINNSMAAVADRDFVVETLQWASTLMQHISRWAEDLIIYSTAEFGFVRLADAYSTGSSLMPQKKNPDSLELLRGKSGRVFGYMAGLMMSVKGLPSTYNKDLQESFEPMLQGVKTTADSIQIATGVLSTLTIFPEKMKAALTPDMLATDLADYLVRKGVPFRETHHISGRVVALAEKGGIPMDKLSLQQLQGVDKRFSDDVMQAFNYESSVEKRTVLGGTSKKSVEEQIERIQELLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2L6</accession>
    <name>A0A1C1D2L6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-sulphoglucosamine sulphohydrolase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2L6"/>
    <dbReference type="STRING" id="86049.A0A1C1D2L6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03063"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05067"/>
    <dbReference type="eggNOG" id="KOG3867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="SGSH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF6">
        <property type="entry name" value="N-SULPHOGLUCOSAMINE SULPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="SGSH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-sulphoglucosamine sulphohydrolase C-terminal" evidence="2">
        <location>
            <begin position="113"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="300" mass="35368" checksum="B8D63AB9F0A9055A" modified="2016-11-02" version="1">MRVADDLTYKDLGLVQADGGRRKLGEMMWDGARKIPNNAPGLRLIDADNGTVFTFSNDKDLGEFKFQRYMQRYLRTIQSIDDNVGRLLDWLDETGQAEDTLVIYTSDQGFFLGEHGWFDKRFMYEESFQMPFMCRYPREIKSGSVNNDLVNNVDFAPLFLDYAAARKPNYMQGQSFRRLLRGEAIEDWKQVAYHRYRMHNDIIPEAYAHYGVRDQRYKLIYWYCEHMGVEGARPGGEDYKEWELFDCQEDPLELFNVYNDPKYQDIVARMTRLLEDKMEEIGDEPIHILSSRGHLPLPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2Y1</accession>
    <name>A0A1C1D2Y1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2Y1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03228"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT55008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="73" mass="8021" checksum="33953AE7CA870542" modified="2016-11-02" version="1">MTGISHTFAGGLDYEPPRQGHHEPPALKRQLGTVAHLDFECKASECSLGERYSNVIKRVTNGAPVYTDSQRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D3F1</accession>
    <name>A0A1C1D3F1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pre-mRNA-splicing factor cwc26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cwc26</name>
        <name evidence="3" type="ORF">CLCR_02963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D3F1"/>
    <dbReference type="STRING" id="86049.A0A1C1D3F1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02963"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05158"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT55065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="440" mass="48293" checksum="04888FFDBE431896" modified="2016-11-02" version="1">MPGANLAAYLAKNYLTASNAKGSSSSHDQTTSPDFQDSARPKKKRRKNKDSSNSGGGLVIADDDEELSLSRRTVGAHGDDDDDDTPTFDTNVKSAEFRKKKGASAWKVVAPGTATGTATGTRTTGSTESPHRPKEGGNEGDSAAAAAADRILAEAAEESRLRQQGIDDEDAPAIVEAPDDTTTTTTTAPPRMQSGARAGLQTAADTAALIRREEMEAEAELERLERSKRKSDSNSNSKRSKHTKDTRASSERPEEEETIYRDATGRRIDVSLKRAEARAAEQEKLRAEKKAKEDAMGEVQRRERDEKRKQLDEAKFLTLARGVDDEVMNDELRGKIRWDDPMAEYMAQKRADEAAEEDAANDGPHSAVSARRGAKSRGASAVGRKKVYTGPPAAPNRYGILPGWRWDGVDRSNGFEKEWFQARSKKGRMEELSYQWQMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6D7</accession>
    <name>A0A1C1C6D7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metal homeostatis protein bsd2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_00111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6D7"/>
    <dbReference type="STRING" id="86049.A0A1C1C6D7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00111"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02009"/>
    <dbReference type="eggNOG" id="KOG4812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10003116at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22212">
        <property type="entry name" value="NDFIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019325">
        <property type="entry name" value="NEDD4/Bsd2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396:SF5">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10176">
        <property type="entry name" value="NEDD4_Bsd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="369" mass="40082" checksum="1D240357F33D5075" modified="2016-11-02" version="1">MAPQRYEAVRARRFPIYRFRQLTSVPQLNSHDHDEDSPISPDSPHPIPSSPPPSFRSRASSPTSRRLLSQDPLSPETDRDHLEDTFDDGEASDAENDGDDRQRLMRADTGLSRQDAAPSTTSTPATLPAPVIERRVTELPAFRPMPESMRATDGVFANLSAKPERGEQLEEKPPTYEQAAADATPPYWETTILAPGMSSDEVYVDGLPVGSVFSFVWNGMISMSFQLVGFLLTYLLHTTHAAKHGSRAGLGLTLVQYGFYMSGSGDGSSDTGNPGQFSNSGPPDPNSHNFDPNTVNGQADSFGEGGGMGGFTSADWISYVLMIIGWFILIRAVSDFLRARRHEALVLQSPSRGLSVPVVAEGETPEQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6E5</accession>
    <name>A0A1C1C6E5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">THS1</name>
        <name evidence="16" type="ORF">CLCR_00079</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6E5"/>
    <dbReference type="STRING" id="86049.A0A1C1C6E5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00079"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02008"/>
    <dbReference type="eggNOG" id="KOG1637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000019">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="102"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="342"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="637"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT44039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="806" mass="92018" checksum="3E63F54134E2C715" modified="2016-11-02" version="1">MSHQKKVSLNPHDLWGVLKGDNMSQNGTAAGPDSSSPPSQTSKRPVSPTANKKVPSRPKEMSSQAAPAAHQAPKSLPDFVLQRNEFFDQLKKEYDLELASRDKPAIQIKLIPAPGQETTVEGKAWETTPGQLLKNVPKDRAGQIVVAKVDDQLWDLDRPLEKDSKVSYLTFSDSEGRDVFWHSSAHVLGECAEHEYGCRLSHGPPTAMGFFYDMALEPGQAVREAEWPSLENRAKKFAKDKQAFERLEVSKDNLRKMFGYSKYKMHYIEKFVPDGESSTVYRNGTLVDLCQGPHIQNTRKIESFKIMKNSSAYFLGDQSNDSLQRIHGVAFPSKQQLKEWENFLEEAKKRDHQLIGQQQKLFMFSKMSPGSPFLLPHGTRIFNALQAMLRDQYWERGYQEVQSPNMYDVELWKTSGHWQHYQDDMFRVQVKDDSADPMPLSDKKPDGKTPLAEIKDKDKGVFALKPMNCPGHCIMFRDDDRSYRDLPWRVADFGVLHRNEASGALSGLTRVRKFQQDDTHIFCTNEQVQGEIEALFDFMSHVYSLFGFPFKLKFSTRPEGYMGTLEEWNAAEARLKQALQNFRGDDWEMNEGDGAFYGPKIDVTISDALGREYQCATIQLDFQGPQNFRLEYRTSEGGADASNQADQKTGDRDPKAPGVGMARPVMIHRAIIGSFERFIAILCEHFAGKWPFWLSPRQILVIPVIKAAEDYVREIQAIFHKARMYVDIDVSGNTLQKKVRNGQLAQYNFIFVVGAKEQETRTVNIRNRDDQATQKMGELIPLEKALERLTKLRDERRLENKIDMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6J0</accession>
    <name>A0A1C1C6J0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6J0"/>
    <dbReference type="STRING" id="86049.A0A1C1C6J0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00665"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01027"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="10"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="372" mass="40217" checksum="DC8294E9C397FCF1" modified="2016-11-02" version="1">MASSNTLPVQTLSATVHPTNPITTTISTGPLPESLAPSDVLVKVEAAASNPKDWLHLVATGASLNSGDDLAGIVVAVGPEVTRFKPGDRVAAFHPMGKPYGAYAEYAIAPEHTTLQIPDALSFEEASTIPLVSLTAALTLFRRQGYVAPWQAGAQEENQKKPLLVYGATTSLGTYAIRLAKLAGIGPIIAIGGGSSNYVKGFLEARQDAFLDYRTGMESLKETVKRLTEERHLQLRNGLDAVNEHESWVQVSQMLRGEARLSVFSGARKYDEEAILKNVDIIYTFVGTAHEAKYRPSMPKQPSVEDAQGDVAFAGEFFAWLEQMLRQAKYSGHPFEVIPGGLKGVSEGLNRLRNGQAAGKKFVYQIGSMAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6T1</accession>
    <name>A0A1C1C6T1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">rvb1</name>
        <name evidence="18" type="ORF">CLCR_00633</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6T1"/>
    <dbReference type="STRING" id="86049.A0A1C1C6T1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00633"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01144"/>
    <dbReference type="eggNOG" id="KOG1942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="63"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT44220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="457" mass="49550" checksum="7A5AB37DA83940C1" modified="2016-11-02" version="1">MVNISEVKGNARENRTAAHTHIKGLGLRPDGTAEPSGHGFVGQAAAREACGVVVDLIKAKKMSGRAVLLAGGPGTGKTALALAVSQELGTKVPFCPIVGSEVYSAEVKKTEALMENFRRAIGLRVRETKEVYEGEVTELLPEEAENPLGGFGRTISHLVITLKSAKGTKKLRLDPSIYEAIQRERVTVGDVIYIEANTGACKRVGRSDAYATEFDLEAEEYVPVPKGEVHKKKEVVQDVTLHDLDMANARPQGGQDVMSMMGQLMKPKKTEITDKLRAEINKVVSRYIDQGVAELVPGVLFIDEVHMLDIECFTYLNRALESPIAPIVILASNRGNALIRGTQDITGAHGVPPDLLARLLIIPTHPYNAQEVQTIIRLRSKTEGLSISEPALERVARHGTNVSLRYALQLLTPSSILAKVNGRSEISPDDVAECEDLFIDARRSAKVVEQAGGLFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C772</accession>
    <name>A0A1C1C772_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_05492</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C772"/>
    <dbReference type="STRING" id="86049.A0A1C1C772"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05492"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07080"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000595">
        <property type="entry name" value="Protein kinase, putative (AFU_orthologue AFUA_5G11840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF137">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="387"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="97"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="606"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT44385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="748" mass="81828" checksum="7C022A7A0A6AEC13" modified="2016-11-02" version="1">MTSKLSAMFLPGDDTKGEKEAKPELEEKKNAQSAQGAVRFTSDDEEIDPLDESRRISEAGGVKNEELSPEAHEQIRSLAMSLQKSRLQESRMANFAYETVSMPPSREFSQVPSRDSEAPGTPRGSIRHGHGSMSSAFQSPPLTPHGSKDGKHDSVSAGRGQSGQNAITPQTSPPPDQHGRALSQSISPSQPAPSSSNEQPSSKPDQGQERRVARFEIGPSESTSPADQSPVGTPKLRPSSPQPGGQQKQTEPRHFGSLGRGSLAPAIAAAAERIPRQPSSSDISGSDKRSSIFGPSKKDPYSHVTDSGNERTGLEGKKHGSMSELKRFFRLGHGHKKHSTPQESPAASVPASRKSTNQKSGTRTPPHQAPPANVPFMDDHSLEAKYGKFGKVLGSGAGGSVRLLKRSSDGVTFAVKQFREKHSWESEKDYSKKVTAEFCIGSTLHHGNIIETMDIIHENHRWYEVMEYAPYDLFAIVMTGKMSREEIACAFLQIVNGVSYLHSMGLAHRDLKLDNVVVSEHGIMKLIDFGSATVFRYPFENEIVLASGIVGSDPYLAPEVYEEKKYDPTATDIWSLAIIFCCMSLRRFPWKQPRLVDNSYKLFASPPTPGTPVPDSHPRKHSQLNPVDDHSTSRHNSEANGGTQSSHHGHHHSESVDEGRPSTSGGDKQEVIKGPWRLLRILPRESRHIIGRMLKIDPAERATMEEVLEDDWVLNAKVCYQEENGTVHHAEGHTHVLEAGSGGPPPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7B7</accession>
    <name>A0A1C1C7B7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7B7"/>
    <dbReference type="STRING" id="86049.A0A1C1C7B7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05465"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07058"/>
    <dbReference type="eggNOG" id="ENOG502SRG9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5404794at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="864" mass="92528" checksum="2D7B5EA098965C90" modified="2016-11-02" version="1">MPPEIADSDAESDFGSPVKQAHMSGYTTETVRPPLASPSEVDFDQFLDPTQRLSSSASYHVGNISQLDGSGDNSTGSGADGASADTHSTSLSLHMSPAVKARKRAHSALQDVVNNVSHDSSDKKAKSKRSKTYGPASRSRSTLGDDLFAPSLASLTELDNARPEDPDANTANREVSGSPLASNEPSMLAGTSSSRPPGVNSALGGPVPEAAPLMTTSMASIGQYQSINLDFRGGLDVNANPFGPMSQVSQEGETNQGGTENRKGLPQAAGQQPPHRSINPSNLDVTEEQLLSPTTQSCPQPSAINPARLIPTDDPAPTSDVINHPQAFEAIAEGTDPAAETVLPSTEKLPPKKRGRKAKNSTLTSTLRAPSLSEDADELALPSMPPPNRSRRATVDSLSQASEMSGPASSTKTRKRGKSKPVVVDEAVEGDESSPAKLPSNEPALSDEVMIGLPKEAYKPRPSRSRSKIGEEETPPRRPDESSPVKPTSSGSNLSDEAAIGLPKDNYKPRPSRSRSKKVVDEVPGLLLPEEQPDHQTPARSIATNAPEVETPPVPSTKSSSKKGRKSKVKRAKTSAAALLKKVEPMLSEGEEDVVWMDTKPAPVKLDLPPDLKALQKEPDVPDSREDEDVRHSHERTTGKDTHITIEIPSNAELKNPMPEPKKRGRKPKKVQQKEEEKAVDEEEDKPPQDDDMKKRPALAENSSNVRGLGPGLDTLESPTGKGAKTTPTVSPFTSPEPESRPPSKATRAPVEEKENRLLTTPAKPKSSAPPPCSAEKGPTKHSPITSLTTSGRKAIYRIGLSRRQNIPSLLRKVDRDKPPPKNVAIKQKEKRVKMDETHDGDEGSGRDPGEMRGPDGMLIEWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7X8</accession>
    <name>A0A1C1C7X8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">RNA lariat debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CLCR_05356</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7X8"/>
    <dbReference type="STRING" id="86049.A0A1C1C7X8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05356"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07240"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07241"/>
    <dbReference type="eggNOG" id="KOG2863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="1004"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="659"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="730"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="927"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1153"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="681"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="730"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="767"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="806"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="847"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="878"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="961"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1153"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1172"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1201"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT44562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1221" mass="134829" checksum="341C36958C8D2CCE" modified="2016-11-02" version="1">MTATTHPEFNAETEALDVAKAFPDAIRGKTILVTGVNIKGIGFTTAQAFASQAPAHCILAGRNRSKLQECIEELKKECPNVDYRALILDLGSQRAVRSAAQEVLSWDGVPSIDILINNAGVATMPERTLSEEGIEMTFATNHIGHFLFTCLVMPKLIEAAKANRKGATRIVNVSSHAAEANGIRWSDLNFEKKSRELPEDEQPNYKLLELWSISNAPDLSYIPLEAYVQSKAANVLFGIGLTKRLYEKYGILSLAIHPGVIDTELARHSTKEQMAAIKDRERRGEFTYKTLSQGASTTVVAAVDPKLGVSVTRDGKEGYGAYLMDCQISQNAHPRAKSSDEAEKLWRVSEDLVGEKFSCEKCGLGELYPSILEVEVRNERRDERVRAKDVLARSVSTPWSSSTEAKGKMSGVEEQKSAGVRVAVEGCGHGTLHAIYASVEQACKVKGWDGVDLLIIGGDFQAVRNQYDLNVTAMPHKYRRMADFHEYYSGSRTAPYLTIFIGGNHEASNHLFELYYGGWVAPNIYYLGAANVLQFGPLRIAGLSGIWKGYDYRKPHFERLPYSQEEITSIFHVRELDVRKLLSLRSQVDIGLSHDWPQGVEYHGDYKWLFGKKPDFGTDSYAGKLGSVAARQCLDRLRPPYWFSAHLHTKFAAIFQHNQDQSATDGTPRPNQRIGRPAENSPPNQTSEYSQGSRVAAPAKDRPLVSAWQQFHVGAQQADAEERDKILKEREDQRLEEESTGKSPRPQYSFNETSNEVAQGEDLRRTIVSTTQSRLQNPEEYQSIPQLDGCSYSRPNKRQRVEDEQQTASHDLNQDSAEQTASRDQMDGRSGSLLLPPQSAIANPDAIDIDMSDDEDATAVASDATSQAKSIPIADPAPRADRSYGETRVDDSKSLSEESDDGGVTLNPQAASFAPVPGISLLRAEQAAAELRKPSDPALEQSVEESEPQNASRTGAGEPPAQSTQNHSANTTSQVSEEMRAQLAALSSNFTAKEPTETSPPLPFPEGITNKTTHFLALGKCEMYQEFLQLLEIGSMTSPGETIHRPLKLSYDPEWLAIQRVFAPELQLGGVPTDRVSAHRGETYYRKRIEQELDWILEHVVKPGKLQVPENFAVTAPVYDPSLQVRSDEMPREVTNPQTSAYCDLVGIENKFDSSEQDRDFRMQQGPRPQSEGYNLYQNRSRQQGRGGHRGGGGGGDRGQGRGRGRGGGRGRGRGRGGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C800</accession>
    <name>A0A1C1C800_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_05845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C800"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05845"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07280"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="367" mass="39965" checksum="4E1931FCC07240F1" modified="2016-11-02" version="1">MNTTEEPERDLESSLDDKQNPTTIQHNEVVGQWDEKTGVAKGDDSDGRVNWTWKQILATISLCGVYVGSQIPLYFVGGSLTYVASDLGSASTGWLPVSNSLALAAVCPFCGYLQDMFGKRNISILGSILILVGTIVTATAHSFAQAVAGMTIAGAGASIGELTALAGTAELVPVKKRGIYLACVTFFICPFFPYVLYSQLLSAHATWRWGLWITVIYNGVFFGGVLLFYFPDSHILRKGTLSRAEIAKRIDYVGAVLSITGVILFLVALQSGGSSHPWKSAYVLCMLFIGAALIAGFVVWEWKGATYPMVPKDLFAGQRVVAIALAVAFVSGMNFCEFQERLRFRRACDYHIVGAPDWLMDTHRLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8A1</accession>
    <name>A0A1C1C8A1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative importin beta-5 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_05409</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8A1"/>
    <dbReference type="STRING" id="86049.A0A1C1C8A1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05409"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07449"/>
    <dbReference type="eggNOG" id="KOG2274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="23"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT44773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1056" mass="115074" checksum="C0286E6E5B58918C" modified="2016-11-02" version="1">MEQQVLQLLQATTRPDTAVIRDAEQSLLRLYPQQDFPFALLTIASHNDVESSSRKAALTALKNYISATWSPQLDETFTGHVYLNDEAKARVRDQVFAICTLEGTQAPKDATIQALAAGVASKIATVDFPDAWPSLFPSLLTILNTSTDDAPVHGALRVLAELVDEGLTEEQFFMVARDLVNGLQHVAVDSNRGLIVRAMTLNVFRACFEMLEMVMADHGAAVKQFLTESLKAWMPFFMETLKQPLPEVVKPDDAHLRGLVALKVQVTLDKLRSVYVQAISPHATALFEIVWQELSRLAAPYAQLFIEGTAEGKLVDSDNLPCSLDALVLEELDFLQITIKAPPVRKELSAQMQQFGDAQHTVPWLQELIRVLVLYARIPKEEEALWEYDANLYLCEAASLTANYTPRAACAEVVVRSLGEWLKQLPIVAMLHFNQHHLQAAATWKERESLLYLLNQSLKDMEEVSGKLDPQTASVTLEQVSSALQDPNLFMRAAAQMVLGCFFKITSNNNADYASAGAAAFANAITASASDPSDVVKVACFLILPDYIEALPRNITQPMQSAIVNVVGDFISSRDLRDELEDADDVKAALIQLLRDAIMLDTSTLMSPENNAIDLFFTLASDGASNFQLFTLLTEAFEGIVSSVSTAGQDQYIRLCAKTIPSLTGAFDIANITQESALTNLAAELVSALAEFGSDPLPAGFVQAVMPKLQRVLMEATEAELVRPATLALNHMLSKGTAQFLEWRDSTGKPSIEVTLTIINRLLNSPDVDENAGQEVGGLASSLVSKFGADKMGPYLMDLLRAVAIRLATAERIQFIQSLCMVFVGLALAAPKEVVDFLAEVNINGQNGLGVVLTRWLENSVHFAGFDEVRQNVVALSKIFALHDERVRAVHVKGDLIVDAAAASSGRIKTRSQAKLNPDRWSSIPADLKILKIMVDELASAATSQFPDLAAAQAAADALDEEDDEAEDADEWEDVGSAGAVDLASAAVRGDLMSLAKEFGGDDGAGASPTGSRARDEETAEYLLNWFKGEAGKERFLGLFEQLSEEEKGKLRELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8U3</accession>
    <name>A0A1C1C8U3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_05833</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8U3"/>
    <dbReference type="STRING" id="86049.A0A1C1C8U3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05833"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07550"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF9">
        <property type="entry name" value="SIMILAR TO AMMONIUM PERMEASE, BUT NOT NORMALLY ACTIVE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="7">
        <location>
            <begin position="18"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="453" mass="48758" checksum="CDAD688A3FD666FD" modified="2016-11-02" version="1">MISDVRKGWEACDRTDTVFVLVCTVFCWPIIPAVGLGYSGYSTRRSGLASFIPAVLTVCVCSIQWFVIGYTLAYGEGPGGVVGNLRYAFHRGVLAEPVGSIPAVLFSEFQLVFEATVCAIAVGGACERGRILPLIPFIFLWSTFIYCPLAHMVWGGGFLSELGVLDFAGGTPVHICSGATASALSLYLSYPIARSRKSDVRTPSHLKLHRPHNSMCQVLALIIIWGSWLAFDAGTTLTLSFQSVMALCVTNLCASAAALTWASITYFETGRWSLDSTFMGAIAGLVMITPAAGFIDLPTSLFFGILGAAVCRQALRIKFTDFARKWRWVDNGDTFATHCVGGFLGTICTGLFAQKSVAEYGGVEVDGGVFFDGNIRQLGVQIVEALIGFSWSFAGSFAIIALIDCIPGLEVLAEDKEVNMGMDASQMDESLYEAQWAGEEDYKPLANGSIILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8V4</accession>
    <name>A0A1C1C8V4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8V4"/>
    <dbReference type="STRING" id="86049.A0A1C1C8V4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06401"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07549"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF28">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="73"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="147" mass="15843" checksum="8B5A4497BE345C3F" modified="2016-11-02" version="1">MVVDTEKAPPVGDVPVIADGRRASLRTGSIDDVQIMDQLGYKPELNRNRSMATLLFQSLAIAAIPYGEGGPLISAIYGGGPLSIFVGWIVVLVMDECIALSLSELASKYPTSAGPYYWSFQLATKGKTALSFITGWTWLVGNWTISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9A7</accession>
    <name>A0A1C1C9A7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sphingosine N-acyltransferase LAG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LAG1</name>
        <name evidence="13" type="ORF">CLCR_05865</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9A7"/>
    <dbReference type="STRING" id="86049.A0A1C1C9A7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05865"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07789"/>
    <dbReference type="eggNOG" id="KOG1607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="154"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="380"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT45123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="434" mass="50505" checksum="4A3602BEA8FD11DD" modified="2016-11-02" version="1">MARPRRTSSNLGGDPRGDTGAPALATMALRPTEQISARERDLKPHSKRRKARSAFRKWKQISLRHTWLNPLILLLALLGAYYINPGEQNPLHQAIFLSYPLGPDYPGGPNMYGKGKADFAFVGFYTIFFTFTREFMMQRVIRPMAIRCGITKRAKQSRFMEQVYTAMYFAVFGPFGLYVMKQGTLWYFNTTAMFEGFPHRKHEGIFKAYYLLQAAYWAQQAIVLVLQLEKPRKDFKELVFHHIITLALIGLSYRFHFAKMGIAVYITHDISDFFLATSKTLNYLDSIIVGPYYLMFMGIWIYLRHWINWKILWATLTEFRTVGPFDLNWETQQYKCWISQYITFSLLACLQAVNLFWLFLILRIAKNYVFSNITVDERSEDEEEEEDTNIPGKDEKKPLENAKVNGNRPVVLINGEPVEGESRPDGVRERKRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9L6</accession>
    <name>A0A1C1C9L6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative urease accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9L6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06127"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07877"/>
    <dbReference type="eggNOG" id="ENOG502S9IJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5876637at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644:SF1">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="187"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="315" mass="35252" checksum="4B261A03551230AC" modified="2016-11-02" version="1">MPHKHKRKRDDDASNYDLPPTQRAKTLAVHQKADPIFTSDIERKRRRGERKQKKEHQKNQYREDDTPKAFKRLLAFQDGKRIRSGLDDGTAPSKKRRKGDAKSNSTSTSEPTSIAPAQFSAGGHAGPKSNDGAALAADRAPSLKIKPNESLSSFSARVDQSLPLTSVAKHKTKLAQIAGLEKIKTPLSKHNKRLARMQKEWRNTEQKLKAKEEELDDELADKREEDHLVWLGAGVDPSNPLGKKRRKKGAGKDVDDADPWKILEKKRREEGELRQRSLQDVVTAPPVLKPLKNIFKDKSLRVGITGTPGIPTQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9V6</accession>
    <name>A0A1C1C9V6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9V6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06477"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="90" mass="10747" checksum="57F0BB9592EA5498" modified="2016-11-02" version="1">MSIRRGSVVRGNFQEVEEREVISRRQHAEASPLRRPRERSPQPRYESEIVQPGGIYVDVDDGGPQRRPRIVQTHTYRRDRDRLWYSSTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9V9</accession>
    <name>A0A1C1C9V9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CLCR_05393</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the replication of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9V9"/>
    <dbReference type="STRING" id="86049.A0A1C1C9V9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05393"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07964"/>
    <dbReference type="eggNOG" id="KOG3657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08641">
        <property type="entry name" value="DNA_pol_gammaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000035">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000003">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000006">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047580">
        <property type="entry name" value="POLG_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="16">
        <location>
            <begin position="691"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1059"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT45324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1153" mass="130470" checksum="6A1FA7409B53628D" modified="2016-11-02" version="1">MLWPPTPAQCARGYIRTSQKFRLRPQFAARATAILRRHYASETSNPNTERRSLARVASARYNEIGVQQLSDHLHPQVFLSRATRPRADLVELSKDHLRRHGLLGKNQDHNAAVGLDAPPIVGRSLDEHFTKLAMDASEPYLSYANAFVRANTPQRPRKWVIRSGWTKYHPDMTTEEVDAPEETMLSFDVETMWRESPFAVMATAASSTAWYAWISPWLLGETENPRQLVPLGDPRKPRIVVGHNVGYDRARVKEEYDLKQSRNFFLDTMSLHVAVNGMCSRQRPTWMKHKKNRDLRDKMSGDHNSIELQRMLESKMLSEEEEELWVGRSSINSLRDVAKFHTGITIDKSQRDYFGELDRDGIMQRIEELLDYCAADVAITHKVFQKVFPNFLETCPHPVNFGALRHISSVILPVDKTWDQYLESAEATYQQRLKDVQDRLLQLCEVALSAKDKPDIYHSDPWLSQLDWSGQEIKYKKAKKKGEEPVPVARQKKPGAPNWYRDLFTSNSSPISLTVRTRIAPLLLKLCWDGFPLVWSDLHGWTFRVPSGEVHKYEHSNAVSCDMANEENIKLKCDHTHTYFKLPHKDGPSARCTSPLAKGYLQYFEAGTLSSQYPLAKEALEMNASCSYWISARDRITSQLVVKEADRDPSLAGKSNQGFILPQIIPMGTITRRAVENTWLTASNAKANRVGSELKAMIKAPPGYCFVGADVDSEELWIASLVGDAQFRLHGGNAIGFMTLEGTKAAGTDLHSKTAKILGISRNDAKVFNYGRIYGAGLKFAATLLRQFNPTLSEQQTTEIASKLYKETKGTRTRRKLLGNGSFWRGGTESFVFNKLEEFAEQERPRTPVLGAGITEALMRRFINQGSFMTSRINWAIQSSGVDYLHLLIIAMDYLIRRFNLDARLAITVHDEIRYLVAQQDRYRAAMALQISNLWTRAMFSQQMGIEDLPQSVAFFSAVDIDHVLRKEVDMDCVTPSHPDKIPHGESLDISQLLEMGDKAYLDPNVVPQDGPIDLDKYKYTQRKSVMEILDGDGESDLAYVRAQITSDDKELRDIIKDIEKESSSAGEKATTTKSGTTGTKGSGSSGSGLPRGRRPKPKVPIPAHAQPQQAMLMEVEDRWSMGYNKAFGGDKPWLTEKKSDWTRKWASDGWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA47</accession>
    <name>A0A1C1CA47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CLCR_06071</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA47"/>
    <dbReference type="STRING" id="86049.A0A1C1CA47"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06071"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08027"/>
    <dbReference type="eggNOG" id="KOG0036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="6"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="126"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="229"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT45395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="322" mass="34562" checksum="E91C20DB67BB9F13" modified="2016-11-02" version="1">MLTDYIIPLGYFIAGGLAGMISRTATAPLDRLKVYLIAQTNPKQAAVAAAKEGAPLQAVKNFGRPLIDACKDLWAAGGLRSLFAGNGLNVVKVMPESAIKFGAYEAAKKAFAEFEGTDPKHLHPTSQFLAGGIGGAVAQCVVYPLDTLKFRMQCETVGGGLHGNALIVQTARKMWKQGRLAPYYRGLGMGLAGMFPYSAIDLFIFEYCKHYVLARKAKKNRCHEEDVEMSNFATGVIGATSGAISATAVYPINLLRTRLQAQGTVLHPPTYKGIVDVTIKTIQGEGVKGLFKGVTPNLLKVAPAVSISYIVYENSKHLMGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB54</accession>
    <name>A0A1C1CB54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nad dependent epimerase dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB54"/>
    <dbReference type="STRING" id="86049.A0A1C1CB54"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01596"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03646"/>
    <dbReference type="eggNOG" id="ENOG502SJ62">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="365" mass="38486" checksum="C7F7E0593C417BC9" modified="2016-11-02" version="1">MSHSILLTGVSGYLGGSLLAQLGKTDAHALPAHKYKKLYALVRTDSQASAVQAYGAEPLRFDVKDASAVRAALLEHDISVVFFLIDALAATTQAHFIDALGEVKAKLGGTGAVTDVHFLHTSGAKIFSSHAGAPTEGPLFDDDPALYDVQKAQRPVVPLLQSAIDANTTAVDRAEARGVRCYIFVPCIVYGRGRGFGNCISIQTVAIVKAARAARRVYSVDDPPSAAVWPVCHVDDNTSLYLALLDAILAGKSPASGKQGYYLASSGSILWGDLYGAMARRLAERGVVDHPDVLPAAGNVDVLTTMGKALGCPPALVALMLGGRCTFTARHAGAELAWTPRFKPEHILDTAAEEVDLILDNLADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBB1</accession>
    <name>A0A1C1CBB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_01705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Zeta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBB1"/>
    <dbReference type="STRING" id="86049.A0A1C1CBB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01705"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03643"/>
    <dbReference type="eggNOG" id="KOG0868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005955">
        <property type="entry name" value="GST_Zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01262">
        <property type="entry name" value="maiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="104"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="231" mass="26257" checksum="D73C6B6A03780368" modified="2016-11-02" version="1">MSDKLKYRYTLFSYFRSSCSARVRIAAHLKDIPLEYKYVHLVKGEQHSTEYHTLNPSDSVPTLVVSDRQTDKEITRIRQSVAILEFLEEVEKGNGVKLLPANDNPVDRARVRELVNIVASDIQPVTNLRVLNYIKPLNIEAQQWQQHFMCLGFGAYEELVKAYGGKYSVGDSVTMADCALAPAVDGALRFGVDVRGEFPHVWQVWEEIGQLDAFIKGRWNAQQDTPEDLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBN3</accession>
    <name>A0A1C1CBN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00539"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="71" mass="8591" checksum="CC1F4E0802BBEEB8" modified="2016-11-02" version="1">MDFRRVLGRFSGFRPYRTLALPQRLSLARRKNLEWRPMRQLKLRGMLNGGVKLERRQRDCNVELQQEEGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBY8</accession>
    <name>A0A1C1CBY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-1,3-mannosyltransferase CMT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00434"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10362"/>
    <dbReference type="eggNOG" id="ENOG502QRBX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF5">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE CMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="501" mass="57326" checksum="E3D8A1817FD8BF31" modified="2016-11-02" version="1">MSVASTLFARGSDKLYLAILLVCVVVISCLNGPFASLFHADTDGVDDFGYRATGIEGDIHLSDFELGDIAEDTTSKGAVSHFYEGEWEPPGIPDLDPERNKIVGEFINAIMDPKDRTFPRLRCPRPIKERYEILRRRRNFATRWDTPPRRWFFALNLYQCSHVLPRLMASVVEAIRFLRPEDCVLSIVGGRSNDGTTEILAKLREEIEAMNVTYYFSTSDVDPLKSGNDRITELAILRNLVMDPLVRQPELYDPDTTVIFLNDVSICTDDILELVYQKVYQKADMTCAMDWVDHGETFYDSWICRGMSGDMFIEIPQSGSFEFKHNLFWNDPDTKTRFEAKLPFQVYSCWNGGAVFTAKPLLQHNVTFRASYKDECYMGEPTLLCKDFWKHGHGRIAVVPSVNIGYNDDESRGTKKKFGYATEIIHRAEDEMGLGKYSKIHWQDTPPDLIKCEPDWQHPTWVRWDEAKEQVPFDWTHSGYFNAEKATEEGVSFEDGGGVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCW2</accession>
    <name>A0A1C1CCW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Quinate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">qutD</name>
        <name evidence="11" type="ORF">CLCR_01169</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01169"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09165"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="44"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT46364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="531" mass="58057" checksum="F4D997A201D725D5" modified="2016-11-02" version="1">MASSSSATGYRLLQQGEPSESPTTSTAQDIKMGKALGTFRACYVVALCCIGSFLFAYDTGIVGGVLTLPSFQNDFRYTKAEKTQVNSNCVSILQGGAFFGCFFIWPLTAWLGRRWAFVISSVVFCIGCILQIVNSHSLGLFYAGRVISGLGTGAATVLVPIFSAEMAPKEIRGKLGSCFQLFFATGVCISYWVDYAAQKGISETSSTQWQVPIGLQLVPGGLLGLGMVLVKESTRWLAKKGRNEEAYASLLWVRGGVDSPEIRAEFREILAGVELEIRESEGVTWKELLLPSNRYRMFIAITIQLAQQLTGNTSLAYYAPQIFATIGAGNKTLFITGFFGLVKMAGVALFITFFVERYGRKIPFMAGAFAMGSFMLIIALIVATHPPSPSATGITSSGAAGIAMVYLEAFAFNMSWGPLPWLYIGEIFPNRIREIGVATGAASQWLFNFVMSQITPHAIDNIGWRTFLMFAIFNYAIIVYSYFVLKETTGKSLEEMEVVFGTVDHLPSKDDDEVESQAGQEEAREIRESTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD48</accession>
    <name>A0A1C1CD48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_01109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD48"/>
    <dbReference type="STRING" id="86049.A0A1C1CD48"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01109"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09142"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT46388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="548" mass="62153" checksum="DE153116ACF0549C" modified="2016-11-02" version="1">MAFLSVVLLAQALLILALVLRVVYRLTLHPLSRFPGPKFAAATNLYAIYYDLLSGDSLVKHLKALHDEYGPIVRVRPGELHIFDWDAYRMVFKAGSDFNRAPEFYNAPMVEGSFLNVSDGRVAKPHRDLFIQAFSRAQINGLEPLIHEKVDLFLHRLQEEASQNKSIDLVMAYECLTADVTMYYCYQMSLGLLDAPNFRPKLIVEFHEFDSVVPFFWYFPNIGNVLNKVIFSLLPESAVKTWFPGAASMKDVMNVRFDYSLLRATRTETSQQCKDLIDSLARAPADSKEVESSIFRNALSPDREKGQYIATPRELAADAVLVFLAGTDTTAHALTFGTWEMIKRPEIWTRLRQEVMSVLPETQGFARLADLEKLPFLATVQRGVVKESLRFSMGTSARLHRIVPQQGAVFCGETIAPGTRVSFSHYLYNNDPAVFLDPFSFKPERWMEPNADELERHMVSFSRGSRSCIGMKSVRSDFLSKQLRRHASPTALLILPSSLAYAELYTTFARLARRFDLVNDGTTGEMMDWTDSYTPRFKGSLKVKPRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDC3</accession>
    <name>A0A1C1CDC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1748-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02156"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF1">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650780" description="DUF1748-domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8523" checksum="F6DBA97DC5A6C00E" modified="2016-11-02" version="1">MVLGRLTHFAFDAVLISAFLAGVKRSTGLTPTSIKASSLGESKEVQTWVDRYLGVGEWVMDQSIAVMGSSSWFERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDQ9</accession>
    <name>A0A1C1CDQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione S-transferase omega-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gto2</name>
        <name evidence="2" type="ORF">CLCR_01994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDQ9"/>
    <dbReference type="STRING" id="86049.A0A1C1CDQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01994"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01400"/>
    <dbReference type="eggNOG" id="KOG2903">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF23">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="203"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="383" mass="43762" checksum="9F5A0ECF60433C6D" modified="2016-11-02" version="1">MLGYPRRRLSLAKKIIPSSKQTIPRQMSVTMASTSAIAVGRPSPSTVAEHLVGSAQAWHGQITPDGPFPPQRGRYHLYIGLFCPFAHRANLVRHLKGLTDIIDISIVKPYPKGDEHGWPGWQFPSSDDEYPHATVDHLFGSKYLHDVYFKADPEYKGRYSVPVLWDREAGTIVNNESPELMRNLQVAFNTLLPEEYAAVTLYPEHLRNKIDEVSEWMQRDLNTGVYKAGFAPDQETYDQNVPRVFAALNRVEKMLASNRGPFILGKELTEVDIRAYATVVRFDPVYVQHFKCNLGTIRHDYPQLNNWLKNLYWNVKGFKETTDFKHIKENYTKSHGDINPKAITPMGPYPDVEEEPYEPDLSKVRVGGVRMPKVMELERQLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDY1</accession>
    <name>A0A1C1CDY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ZZ type zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_01830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01830"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01458"/>
    <dbReference type="eggNOG" id="ENOG502RS3X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjC" evidence="10">
        <location>
            <begin position="142"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="577"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="730"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="772"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="744"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT46744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="853" mass="94735" checksum="38697C7BA41AD9C4" modified="2016-11-02" version="1">MIPQTPSLMVPPDSSAQQLLRLGKPFVEFPRFSILALQEEKDQDGNPLPFSEWLTKRLQSGQPFVIADFDKLDTWPVSGQHDGHQPGFGIERLIELSTKKNIPIRNCSTGRDLSFTLKKFADSARQSYPEFQNLYARDLQCPQEWLEQCRRILPTEVQWGGRLDLFQWLPQCARSEVMMAYVGSEGSSSGFHRCFSSTVALNLLVESDDRPVVCIGTDFDSQKKYDSFISAHGVSPHLDWLNLGSEELLKADFPIYAYDQRVGDLVVFPPATAHQVWNPATLSAKLVWNILHPLSLEVGFDYVQAPFNRLCHPDVARTNLSLACAMLSLLQDNQTMSNSLLPLPPDLPLLSRLFRQMVHDETIEPPVITPITLASIQTGTIATCNFCSTAIWNRHVRCTQCTDFDLCLLCYLNGRSCEHFQSYVWAELIPAEKCTRVLNRAREILGFQPEEPRTLDKRKALGTAVNDLMRAKMSSTTRLCHLCRIDHQEWKGRRCDRCTAFFCFRGLFRHFDEYPAEVLRHKGLWTCPKCMETCNCRCCHFATAYVKSEKPASKRRVKACDPRGKVMGFADNVFDQRRGGRREANTSGTGSSSGQLPGLAQVTGKKRTISSSAEPGPATPLRKIELPTPEPDFSSSRLAFSRESSDYLMDATFSNANGTTFTALLPGVKTITEGHDFAMSPTDERYSRVSTSPGIASLASTTIGTSRIPPGIHHNQNNTLPPILGHGSCTSNGLSIPPRSSVDTFSTPSSAPTTSPTKSVPVTETKTPTAALDASIAELEAQLVKLKKYEEEFIALNLDDSRKMLASEVAELESQIKAKKREKSLILIERLKKEGFGGLAASVGKEVGLGIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE70</accession>
    <name>A0A1C1CE70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_01901</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE70"/>
    <dbReference type="STRING" id="86049.A0A1C1CE70"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01901"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01488"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="68"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="438"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="485"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT46772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="574" mass="64519" checksum="B69092D08E5E6BE5" modified="2016-11-02" version="1">MRSSNLLKRAHSHNKQTLSNLLHSRGTSPHPQPDTISGHKLIEEETNPNYKPEHWYPARIGEVLNHRYELLVKLGYGMTATVWLAKDLHADGQSGNRKYVTIKINVNTLGEDFQKGRRAIAEKLFSANPQHPGYAHVRFMLDTFRVNGKYGDHLCIVYDVLREPIDLCMKKFPGSRFSCGKLRVLLPALLKGLDYMHSECHVVHTDLKPDNVMMGLGDPNILDHFVQHEHDHPSPRKAPDSHGRIIYTSCSDFGESPTEAVIASAKITDIGLAAWGDEKNTKPIQSNVFMAPEVILQAGWSYPADIWNLGVMLWDLVENIGLFDSISTEPDHYRPEQHLGLMIALLGPPPKEFLARCAKAKWYFDADGQFKYPKYVAEDCKFEHSIHRMNAEEKELFIDMAKKMLTWVPEERWTAKQLLEHPFLTKERECYWDTPSLSRASTTSVGSLIPSRSGTPGLPPTSVPNGSVHHSSLPVRLLELLPSLASPDTTEPRLQRQSTNGSLKASENEEKSTSSSTLPLKPKMETLAESKGESNDEAPNKKRVSINKSNESSQAMIDAILNRGKNHTPKPEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF66</accession>
    <name>A0A1C1CF66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF66"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02615"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02267"/>
    <dbReference type="OrthoDB" id="4710922at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="195" mass="20841" checksum="C87D9E4B8BF2CCAB" modified="2016-11-02" version="1">MVFKEVNAGAGANIKACVYLAQKPTEKYTVSWKAGSASDHCMYNTGNDATMHVTDGGLTCTSVGYVEHKASSSGGDLCATDQSVWGLSYHGGRDNVSSGSTLTYWEAAGAFLSKGHVWLVNQSKGTKICPSESNCDAGDVWWRIRDTPDIYIVFVPPASASELGENPDLFDDLAVQGGGELRSVNPGARDRHLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFG4</accession>
    <name>A0A1C1CFG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFG4"/>
    <dbReference type="STRING" id="86049.A0A1C1CFG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02573"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02227"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF105">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G08790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="276" mass="30106" checksum="EFC261E0181616E6" modified="2016-11-02" version="1">MSTQTGMGACCLSGAIHEGSPQGREDTIGGLPTYVAEPSDKSTAKTVVFLVDIFGWKFKNVRLLADNYAKAGFYCYIPDVHEGDSLPIEFLQSVEPPLKQKEQEGLVDKAKETVDVMATLGPWLAKHREAVAEPIISGFINTVRTIPGTNKIGTIGFCWGGRYSILQAHARKEGEIGGVDAAYACHPSLLSIPADLIPVAKPTSIAVGEKDSLLDMKSVDQIKETLEKTGVPTEVKVYKNQVHGFALRSDWSSDEDKKAMDDAEKQGIEWFKKYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFY9</accession>
    <name>A0A1C1CFY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SAM domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_03284</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFY9"/>
    <dbReference type="STRING" id="86049.A0A1C1CFY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03284"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01989"/>
    <dbReference type="eggNOG" id="ENOG502QPMX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000082">
        <property type="entry name" value="Polarized growth protein boi2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037370">
        <property type="entry name" value="Pleckstrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092:SF16">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="238"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="735"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="660"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="801"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="898"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="925"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="666"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="706"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="801"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="904"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="925"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="951"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="969"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="980"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT47386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="989" mass="107797" checksum="08EE8A54AFA484CB" modified="2016-11-02" version="1">MKMSVSSQQRPKAAPQPGDILVAIHDFDARSADELTLRKTDQIELVEMDEGFGDGWYLGKHLGQGTMGLFPGVYTAKLPPHFSPVGATAVRSPQLSPNLAAYTAPTPESVKPATPTSPTMDSSTHRTVTSSPHQHTGLPLRSSVPPSQTTHVHRSIGQALSRRGNGEESPVMNETLSVINEHITDLSTPRQSLAPPDHLAEDTESEYSSHLDRSPYIAGPETDSEENSQLTEADVRSWDAKETAEYLRGLGIDPKHCDIFEEQEITGDVLLDMDQSFIHMKEFDFGLMGRRLKTWHKIRDFQNQLRGGKDSRKSSLKNNGSSEDVTRSQVRGTTLLPRIPSLMEEPGLSIRPSQHTHPYVHVQSTSPVMEHPKSPSSFARSQLRGSTPPSPWRASLATDSPTRPSASSIRDVHHSRRHSSVEYAKPGVQEPPTAHKKNASFDRDWSMSNATTANTSGSAPSLKLNISNQPPSIDLSVDDGENSTAELDRGYFSGNELDNRKARNLLRKRGGAESAGHSRQSSAMDDSSRIGLGMKRHTRLSSVDSIRERALVAISPAAKAYHSRSYKGRFRSASARNLTPIRSPIPQSPTVTNLEEDSLSALSSPKLVNGSTSPLVANPATLTSSSKARKLLGIRAASEAVTGNEKDAAASSTNIISDTLKESPVASPSGSQTPSVTSRSFDMDQTDTSSKGTTEQLGPLLHTKTPVRTNPKTKRQTSAYTKGLLQISPTEARKTCDYSGWMKKRSSGIVAQWKPRLFVLRGRRLSYYYSETDTEEKGIIDISGHKVLGTAADPITSLSTVMTGKSTPSNKSAATSSETSPNVARGSPSGAPFYFKLVPPKAGSSRAVQFTKPTVHVFQVDNITEGRKWMAEILKATIEHDLTSFETTNRQKTISLAKARARKERPPALKGTEDQDEMGKLAELPEQRTPQQEKGEQETGLNIQGLEFNDSDMNLQLGTGSADVNTRVFQDDAERETKDVTTSGKETPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFZ2</accession>
    <name>A0A1C1CFZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03779"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="73" mass="8147" checksum="FE65B0868CF97030" modified="2016-11-02" version="1">MSTQVTLKGPRARLNLGPVDDSIRGVWYPPGGEMQRLLGCSLPSKEDWDVNETRTGGDSRDRAGLNVFATKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFZ7</accession>
    <name>A0A1C1CFZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03742"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01970"/>
    <dbReference type="eggNOG" id="ENOG502SYKH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="76" mass="8537" checksum="20A43393F7DD1C97" modified="2016-11-02" version="1">MNNQGQAAGQPREDYLDKGLDAAEKRFGQGKIDPAKSRSVNEKVTDKARDMFEKATGKDVPDKLNEHLRVFASMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHC8</accession>
    <name>A0A1C1CHC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_03476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHC8"/>
    <dbReference type="STRING" id="86049.A0A1C1CHC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03476"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04487"/>
    <dbReference type="eggNOG" id="ENOG502S0EC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF8">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_6G00670)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650812" description="Extracellular serine-rich protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="46977" checksum="0AD83FB8062E4A2C" modified="2016-11-02" version="1">MRLLYLVFAALLPTALAQESTTTPSITDSSTPTGTSSQAFTTTIAVGRAGHTFAPDVVQVPVGGFVEFDFYPTNHSVIRAEYLNPCIPYEMTGIGKVGFYSGFKPVDAILADPPKWTLQINDSDPIFFYCGAPNSCTTYQMVGVINPNASVSLDTQKQYAADSDFALLPGEPWPDENDPSKTTSTSTATAIYTTSLIATHSSTPSSSVSAPPATATPESSESHHSTLSTGAIAGIAVGGAAVVIAAAALIFFCGRRSRRRAKNEQPTAPTTPAMGPTHPPAYVPPASNYGYMSPSNKHMSMTAMPVTDAFGNSLPNGAPYGGGYPATYPQGYAGQPPMQQSPHMMGAGNPHAYPQHSPSTDIFGTVIPPPGQHMHETQPSTEVHSLRASSPSSMHAAPAPAVGGIEAFLQRQGRMSPQPESEVPGDPVLPHGGVGPYEMAATGTHLRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHN1</accession>
    <name>A0A1C1CHN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_04165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHN1"/>
    <dbReference type="STRING" id="86049.A0A1C1CHN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04165"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08185"/>
    <dbReference type="eggNOG" id="ENOG502RYZU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="71"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="325" mass="36448" checksum="6EC5311A1BB84CF0" modified="2016-11-02" version="1">MSVQWGLPMLKDCLPEELFDRIHTAAVDPNFEPPDPGILPTFNGATGELLKNIPLLRMYRVSRRRFRAFCAQGLNVQYGKVLESVTYDDENSTVTAVFEDGTKATGTLLIGADGAQSRVRTSILGEKGRPSPVPYSAVNLHVCYNDAEKALFVRQAHPINPNDPATWVFQLQTTWKKREGEEVDSLANLKAKAETFGEPFRSANLWIPEDTKVHVNNLSYWVPVPWDTRKGRVLLAGDAAHPMTFQRGQGLNHGIADARGIVLKYKDAVDGKMTFEEAADAYRDELVDRAGEEVRLSMENTEMLHDWERMANSPIMQRGGHPREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHY1</accession>
    <name>A0A1C1CHY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11295"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="116" mass="11730" checksum="A8EFCD527A44F4D6" modified="2016-11-02" version="1">MKTELAELGDIESGNGADVDAEWNSVSIFGRGSGKGTGTGTGNVDIAVVGGKVVMPDDVGGGVEDDDGEEGTTTVSIMRSPVEDVDVDVNVNVDVDAGGVCVCTCRRSIPALLDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI31</accession>
    <name>A0A1C1CI31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_04232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI31"/>
    <dbReference type="STRING" id="86049.A0A1C1CI31"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04232"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08342"/>
    <dbReference type="eggNOG" id="KOG0875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="7">
        <location>
            <begin position="240"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="301" mass="34579" checksum="C40CEDF435AB1310" modified="2016-11-02" version="1">MPFTKLVKNSPYYSRYQTKYKRRQAGKTDYYARKRLISQAKNKYNAPKYRLVVRFTNRDIITQLVTAELTGDKVFVAAYSHELKRYGINNGLTNWSAAYATGLLLARRALKKLDLDEQFKGVEEATGEYALTEAAEGEDGEERRPFKAFLDVGLHRTSTGARVFGALKGASDGGLYIPHNEKRFPGYDQESKELDADTLRKYIFGGHVAEYMETLADDDEERYKSQFSKYIEADVEADGLEELYTEAHAAIREDPFKKDDDEGDKKSKDEWKEEGKKYKVHKTPKEEKERKIKEKIATLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI76</accession>
    <name>A0A1C1CI76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI76"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04443"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="109" mass="11425" checksum="9BAA6F0A7043305E" modified="2016-11-02" version="1">MAGSERIEVGASVRVDRTRNWSGGMKAYSGRNGISSVKKRTLRSALCVRGGQGLSEAPPGVFERPNRKLDIADSLHISDEGCDSYANVGSARGRSPSAGSENGGELCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIE6</accession>
    <name>A0A1C1CIE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_03964</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIE6"/>
    <dbReference type="STRING" id="86049.A0A1C1CIE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03964"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08392"/>
    <dbReference type="eggNOG" id="ENOG502SF40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="415"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT48246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="628" mass="63462" checksum="89A3F4F8C4F28778" modified="2016-11-02" version="1">MDLRPRNFHDRMVELARRQDEVALTTVDGTVYSIAYVTATPTFTGVIGGYTTLTGDDSSATEAPTDQTTAPPSSATNSPTAAATNSATTTLVSSTESSPTSASLIAPAITSSTTSAGIIGSTNTGSVAAASAPANSSAESSSSSGSGLSTGAKAGLAIGIIAIVGLVAVFLLWLLGKKRRQIEAQNGTDNEKNTPAPGVNSTEMATRSPPISATAPRISLRPVSRMLPEFMGASSKSRLSAGNMLNTIGESDSAATRKTPSPQPRGPSPGPARGLGLAAATQSSQDNHPNNPFADPQNPFADPEKLPIQAPAPLVVPPPAAKSAAVAPMASGAIGGASAVSAPPATTVPKPTPAPAPAPAPVKMPVVVPAPVSAPAPAPQLAPQPTSSPASSAPASPALVAAAGQGSNAPHPEAPQGNVYRVLMDFAPSMDDELELKSGQLVRMLHEYDDGWALCIRLDRSHQGVVPRTCLAAKPSKPKPSHLNQYARPAPGGPVSRPMSPAGGPQRPMSPAGRSMSPMGRPMSPAGRPMSPAGRPMSPAGRPMSPAGMRRPVNPGFNQPPRAMSPGPRAGPRAGPPGRSMSPGPYGGRNGPPPMAAVSRRRSNSASNVREKRNSPVGPSKLGPGMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ45</accession>
    <name>A0A1C1CJ45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial substrate carrier family protein L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">mcfL</name>
        <name evidence="14" type="ORF">CLCR_04200</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ45"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ45"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04200"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08585"/>
    <dbReference type="eggNOG" id="KOG0762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF57">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="37"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="147"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="244"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT48461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="340" mass="37835" checksum="F27C960A7CA1E0AF" modified="2016-11-02" version="1">MSAPLSRPQEPHDVSLTSPGQGANQASSEEGRTRAIVSHYKGFVAGVFSGIAKLSVGHPFDTIKVRLQTSQHSQFKGPLDCLLQTLRKEGLTGIYKGATPPLLGWMAMDSVMLGSLTVYRRLLHENIFSNPAFRPGRTAEDLAHEKLPALGHGIAGMMAGSTVSFIAAPVEHVKARLQIQYAAKKKDRLYRGPVDCTRKILRHHGVRGLFHGLFSTLIFRSFFFFWWGSYDLLTTWFKRNTSLSTPVINFWAGGLSAQVFWVTSYPSDVVKQRIMTDPLGGGLNDGTPRFRRWKDAAQAVYRESGWRGYWRGFVPCFLRAFPANAMALVAFEGVMRALPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJD0</accession>
    <name>A0A1C1CJD0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase binding protein Rid1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJD0"/>
    <dbReference type="STRING" id="86049.A0A1C1CJD0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03948"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10234"/>
    <dbReference type="eggNOG" id="ENOG502RXE8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2155261at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="2">
        <location>
            <begin position="146"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="666" mass="74675" checksum="3833D3646B21ABBE" modified="2016-11-02" version="1">MYPRSKRQAVEEECNVYKPRDCSEFRPSEQRNFYGYGPTTPWSLDHKPPQRPFLQHKSSRSSIFKENIPETVEDEPKRPKSRDHHTAQPPSASTPDVRPCLQTQNSDSSQPDKVKRGSRVLQVIQSLNMKTRNNARSAPEARTSTSPPLSPQELDSAFERVLDSLNIPLNMRDGMRNLKPDVKAGLMKGERIGSGSSAASGASEVSEVRSSARNSHRNENDRPKSEGDDSKDRKRSRSQSRPRSRILTLSKRDEDTPDKPDRPRSSSRSRSKSRNKSADLTSSRHTSLKAMASTVSLASLNPADSAAAPGDFIHYLREVQKPQLVEVSKLHKLRILLRNESISWTDHFVSKGGMDELVQLYYRIGKIEWREEHEDNLLHETLLCLKGLCTTSLALHRLQQVEMEFFPALLGMLFDPERKGPSEFSTRGVIISLLFAHLSAVGGTDQEQAGTRARTILHFLKDPAPEEGKQTLDFVSQMHTPRPYRVWCKEVVNVTKEVFWIFLHHLNVVPIINVDESTGYRRAHFPAPRPPHPAAPYVGGVEWEATQYLAVHLDLLNGLIACMPTAADRNALREDLKQSGFEKVMGGSLRTCKEKFYGGVHEGLKCWVSAAKADGWPVEDVRAGPPREAASPRKSPVKRKADEVPQLALDIGAGQGRLAQPDDGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJF6</accession>
    <name>A0A1C1CJF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04305"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10277"/>
    <dbReference type="OrthoDB" id="4161521at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="263" mass="29774" checksum="66830CF6E7DBE10B" modified="2016-11-02" version="1">MDHILLWQDDQFPPAPPPSPCPDQTEFTYAYGLPAGQLTFTWPTEGEYLGEPRAEPSSQSGTDNDAVPVLSATSSDGEGCESAIDSDKHARAVKVTVDAETYLVDILKGDVLTPVWLTDQGQLSPALRHALNDTICDAYMLVKLSLSDHVPSRLGVLEHVERAEVPEVRQLNDGSWEVLVLKTYVPVLCRRLYEARRRFHLDLAYDGFEPRKEDVECWGLEKAKHLCAMWFETRAMEVIRGACYIASVYYRRRLDLLHQRVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK52</accession>
    <name>A0A1C1CK52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK52"/>
    <dbReference type="STRING" id="86049.A0A1C1CK52"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04871"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03027"/>
    <dbReference type="eggNOG" id="ENOG502QT37">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15488">
        <property type="entry name" value="Tm-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12030">
        <property type="entry name" value="Uncharacterised protein family UPF0261, NC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12020">
        <property type="entry name" value="Uncharacterised protein family UPF0261, NN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051353">
        <property type="entry name" value="Tobamovirus_resist_UPF0261"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008322">
        <property type="entry name" value="UPF0261"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056778">
        <property type="entry name" value="UPF0261_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044122">
        <property type="entry name" value="UPF0261_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002674">
        <property type="entry name" value="PRK02399.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862:SF1">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06792">
        <property type="entry name" value="UPF0261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23189">
        <property type="entry name" value="UPF0261_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033271">
        <property type="entry name" value="UCP033271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0261" evidence="1">
        <location>
            <begin position="4"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="UPF0261" evidence="2">
        <location>
            <begin position="198"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="461" mass="49711" checksum="161CD65361728402" modified="2016-11-02" version="1">MVKPTVLIVGTPDTKLDEILYLRGQIVAENTCNTKILNVSHSTPAKVRTRLDNLLAADEVISPLEEHSSTLKDVSRGEYIDKAIELCTPVVKDLVSKAAVHGIVSAAGSSGSSLATALMRHACPVGFPKLMVSTMASGDIKHYVEETDITMMYSVVDIAGINSILKRILSNAAAAISAMTVSFAKSLVDASTVEAKGKRIAITMFGNTTPCVDAVRQILTSAPHDASDYEIYVFHATGSGGRAMERLIAEGQIDAVIDLTTTEIPDELFGGVLSAGPDRLEVAAKKGIPLVVSVGACDMVNFGPKDSVPEKYKDRKLFVHNPAVTLMRTTPEENAQIGQFIVDKLATHASNPSAIRVLLPEKGISMLDAPDKPFHDPHADKALFETIEEGLEATKIDVERHDLHINDEVFAGHVASAILEVMGVTQRNYRLANARRRKWSFDHGASVMLARKNSQIEIPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKD5</accession>
    <name>A0A1C1CKD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OPA3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_05054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKD5"/>
    <dbReference type="STRING" id="86049.A0A1C1CKD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05054"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02950"/>
    <dbReference type="eggNOG" id="KOG3335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT48957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="291" mass="32793" checksum="9BAF61E04AA863AF" modified="2016-11-02" version="1">MSLALKFTSLAVRTLSKPIANYIKRQAREHEGFRRTCISFAQTLHRVDMRWRIGLLQDAAAIERQVAKDAAADAAKKHKHSNVPTVKTEAQTKADEEAAAKAAKEGHEPPKPRPKPKIRPLSEAKAIETGANFISEAFLFGVAASLILFESWRQGRKTNQRRNDVAERLAELEESEKAARLALVELEREVLRLRAKEKNGRPNGPARILPKEIYEERVEEEEKPVSWFSRLKSLVSADEEDKEAKNSLAKNEPGPAEKILKQSDKALEERRKQQQALEAPNKETTSQGPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKM9</accession>
    <name>A0A1C1CKM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKM9"/>
    <dbReference type="STRING" id="86049.A0A1C1CKM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04961"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02856"/>
    <dbReference type="OrthoDB" id="5275938at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="357" mass="38747" checksum="8C25E2371B90241A" modified="2016-11-02" version="1">MAFSSSAPASDTVTDLDLNGDLLLTIGKKEAPDKTRQLRISTSIMTLVSPFFKAMLRGSFQEGQLSLSETNPPNLELDVDDVEAMTTLCQIVHHDKAAQVPVHLEFIVRVATLSDMYGCQTATASWFHSQLLLRPPPTVATFGRDVAATIRASYLLDVPGVFYEFTKAAVQYLSLAKSGEDLVEGLGDALPEGFVDAIKAAQTARLQVIRRECTDLVCRFLPPPGYSPSMTLPDGTTVIVPYVFKYISAVHASGLWSQSGNGAESLEGIPVKAAIELLLQTAKLVKDDELDYACMIEETAMELLEKTHGFCLPCVRTEGKNFTRVAGVKCGVHEVHPDTALSAITGTTEQRPRQPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL25</accession>
    <name>A0A1C1CL25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TOS1</name>
        <name evidence="12" type="ORF">CLCR_04862</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PGA52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL25"/>
    <dbReference type="STRING" id="86049.A0A1C1CL25"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04862"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02765"/>
    <dbReference type="eggNOG" id="ENOG502QSI7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="118256at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018805">
        <property type="entry name" value="YJL171C/Tos1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018807">
        <property type="entry name" value="YJL171C/Tos1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737:SF2">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10287">
        <property type="entry name" value="YJL171C_Tos1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10290">
        <property type="entry name" value="YJL171C_Tos1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650884" description="glucan endo-1,3-beta-D-glucosidase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall protein YJL171C/Tos1 N-terminal" evidence="11">
        <location>
            <begin position="39"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall protein YJL171C/Tos1 C-terminal" evidence="10">
        <location>
            <begin position="207"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT49161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="445" mass="47098" checksum="2A540EFDF7CC563B" modified="2016-11-02" version="1">MKYALTTSSLLALVSSAAVLAQANDCYEEKGNWYCSEVQAISYSNFGTPGQYQKVTNMGSSGECDFGPQSYSGGMAPMDGEVSWHFRGPIQLKQFAFYTAGSDNSKRSIHPNPHQKRYAHKHLHHSGPPAGDDEKDDHAEHKRAVGDWVTATINGQVVSWVNQYDGGAAATPAPAAGGDGGRRLGPGSASAAYSAPGPAASMNAGLGNWGRQAYYNAEQGTAEGLVFLNNHGGQGSGVFDTTWGMSLSYASADNSAGSASPVTLADTLIPDNSEFVIMTDKPCSDGSCGTIRDGTVAYHGFDGASKLFLLEFSMPLSGNTGFNGDMPAAWILNAQIPRTIQYGKCSCWDSGCGEFDVFEVLDSGNQKCKSTWHGIKAKGDSNWFQRPIRGTKKVAVVFDGEASTAHIIVLSDDFNFESTVSQATIAASLSSISDPAKNIRIALDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL73</accession>
    <name>A0A1C1CL73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_04837</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL73"/>
    <dbReference type="STRING" id="86049.A0A1C1CL73"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04837"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02698"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="72"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="183"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT49239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="399" mass="43240" checksum="41A63EB54B9535FE" modified="2016-11-02" version="1">MAAPADDFKSLLALRDSINASIDAYVSLTPEERAKKPKVDQARQQIWKAATKLASETVVPPQQATLIAFQPWLNAVVHTALELDLFNHLGASTTATELSQKTGADETLIARLMRVLTGFNIVAELGELTYAHTPVSQALTTPAVADLNKHIFDSSWECIGKMPAYLKSLEYKNPDQPENTLSHYATGTDFFAYLRNDPARLVRFNSAMKGAGGILASPIPPPLLEAAGAAAGQDGVVMVDVGGGIGQVTEKAMEAHPTIKGRFLVQDLGKIIDEAKAKKPAFEVMDYDFFTEQPVKGAGIYFMRRVLHDFPDSKCREILKNQISAMTPGTSRLLVCETVLPATGCSGFESLADISRTTFSSMQRTEKQWRALLESVGLKVVKVWSAVAGPFGVIESVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLV3</accession>
    <name>A0A1C1CLV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07663"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09761"/>
    <dbReference type="OrthoDB" id="4155216at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="138" mass="15753" checksum="D8BA5BCCA8C2E1C8" modified="2016-11-02" version="1">MSSNPAKYAQLRRDAEHGTRQELQLLIPERYIDDVPECEPRDNPMTKAVKASVAYIKDIVRDHDASTNSNNQPSSVFTPNRTELRLKPVMERVKQHIQGRGHDGEELSDEVKRMMDEATDTLVNIIDNWEGRGQQPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM62</accession>
    <name>A0A1C1CM62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Averantin hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">avnA</name>
        <name evidence="12" type="ORF">CLCR_06882</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM62"/>
    <dbReference type="STRING" id="86049.A0A1C1CM62"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06882"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09841"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT49583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="536" mass="61359" checksum="1C6D61F13005A92B" modified="2016-11-02" version="1">MAVATDVAAIWHYASLAFWYWVYAVAAIVGFSILRLIYNVSPFHPLAKYPGPVLWRATRLAASWHQACGDLYKCIDAIHSQYGPTVRIAPDELSFASPEAWPQIYNTRPQLQKTEFHFGRADERKLPESLIMASDTEHARLRRLANPAFLNTGILEVEPVMQHYVDVLCGQLHEACHAGSQNMVQWFLWTLNDVIGKLALDQEFECLKLRQMHPWPKFLLRGLKNIAIFNQFRRFGITERMLIPLLSKKQLEERDNFFNEAVSAVNQRLAREKSERTDDEENQNKKNPDIVGLMLREMKDGNRLTEKEVTANSILIVGGGAETTSSCLSGTFYHLLKTPRVLKKLQQEIRSNFASAEEITIRATSNLPYLKATVDESLRIFPIASYITPRTTPKGGHVIAGDHIPSGKPFKCWGLNADAETGQWHMGRSDQLFDNPKEFRPERWLDELDINGPANLRPDEILRPFSLGPRNCIGKQQVRLAHTWLALTEARLVIAKLLWHFDMELDGDHSTWVEDARFYVLWELQPLNIKLTPVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMA5</accession>
    <name>A0A1C1CMA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_06778</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06778"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09839"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="81"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT49581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="532" mass="60120" checksum="D4BC19D2E461FADF" modified="2016-11-02" version="1">MAGSDHIVTDTAPESRTEKAVVEKKDVSQIERVMSGGSEPEKDFVDYDRIDKDVAKYANATQVVISAEENKRLKRMIDRRVLAILVPTYFLQALDKGTMSFASIMGIREDLDLHAQQYSWLTTCIYIAVLVVEYPTNWTLQRVPIAKYLSLNICLWGTILALHSVAKNFAGLVALRTLLGIFEAVCQPSFLLLSSMWYKREEQAEIVTFWYVGNGTQQIVGGLLAYCFTKIESGPLKSWQAIFIAYGCFSVLWGVFVGWWMPDSPMKAKCFSEEDKKLMVERVRSNQTGLQNKKFRPEQVKDAFLDPQTYCYCLIQICTTLPTSGLGAFANIIITGFNFTVLQTQLLAMVLGAVIIIILFSSTWLVKKYHQNCLTMGAFVIPSFVGTIVLMTVQNKNTATKAGLLISYYIVLSFWAAQTLAMSMLSRNVGGQTKKSVVVTMNFVSWCAGNAIGPQVFLSWNAPRYFIAFSTHMGCYVLLVIVIIFLRFHLTRENRRKDELASAGIREARDESYVHAFDDLTDRENPNFRYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CME3</accession>
    <name>A0A1C1CME3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">fah</name>
        <name evidence="16" type="ORF">CLCR_07019</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CME3"/>
    <dbReference type="STRING" id="86049.A0A1C1CME3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07019"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09894"/>
    <dbReference type="eggNOG" id="KOG2843">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="19"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="119"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT49649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="421" mass="46048" checksum="57225C9CE4548E04" modified="2016-11-02" version="1">MNMNSLSHVPEDSPFTLDNIPFGVFSTRDDPTPRCATAIGDVALDLRALAGAGFFEDAAVADALSQTSLNAFAALEAKTRTAAREQIIEAVKDGRIPETSRHVLADVTMHLPVVIPEYTDFFCSLEHCKNCAPMMRDGIAQNFFHAPSAYNGRASSVLPSPSLIRRPRGVFWKTEHDGTRVPTYGAEEHLDFELEVGYIVSKPVPYGETIKVDDAPDHIFGLVLLNDWSSRDLQIFEMPPLGPFNSKSFGTTISPWVVTLDALKAFQTAPKHETDPLEHLRYKDFARGTFDVKLAVHLERGGKRHRLATSNLKYLYWTPYQQITHHASANCGLRTGDLMGTGTVSGDGVDAQGNKCELGCLFEATLHGSRPVALEGGGQLRYLEDGDSVVLSAWCENASGRKVLGFGECRGMIVGPDAPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMK2</accession>
    <name>A0A1C1CMK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMK2"/>
    <dbReference type="STRING" id="86049.A0A1C1CMK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06572"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09953"/>
    <dbReference type="eggNOG" id="ENOG502SK00">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4194555at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1239" mass="137916" checksum="3F5F8753FDFDEEC1" modified="2016-11-02" version="1">MTLRHAARLCGELEEDDDDENEINIAFSSDEDDPVTLHPQVHASPAHIPNPNTELDALPLPPARSPTAWQRQTKSSPVEGVAEVPPLHPFQTAFSPETLIAFMREEMDKINRDREASRAKCKGKQKETAAPPALGLSDATLSSVLPSAPPLSDQSNRGQVTSGAGTRRSLRLSRRDSSPLTSLSPVDPPCMVVFPTDPYSQSSDFIQSTRTTTFEEYTKNKRNAVRNNTQESPTSPLRAKLRQPGLSKGATTLDPLAAENIGFAGVVSGMRDLSDLTLQDDHTRQPDQVPPTGFLTRAANIIIRKKAGGNLLGRTPGLSTTSVPRGLDHTVTTLPELPTAGESNTSAGVDEQQRRSRFPFNYAKIIPESIPSNDKKSFLDKIARAKRTQSSGPEHEAQPSSGRSRFRLSSKPKKKDESVATEVKQYPRLWKPSSTSGIPANPPKSGTSRPPQNVATPLSEPVAIWLVDENLWSAISQFLSTQDVKNLRLVSKLHAQILAPIQLRNVVVKFDQKFFDDTIFKNHGPNINRFGVSFEYNLEGLAYASAKIIEKEQEAWFGKFVWPTENYPRFPELQAIEDLVDNNRPLLKQALANITNASELGLCIDSGHGWIEGPDISDMALFEKRISQGSKVFGKTFKTEDVWTTFARNELFRWGQQNTINTTLKSILARQPPPASDGKEVRFLDALKVRDIRSFACQREQYDFDPECHTGGVATVLDLDPAAAVDPQVNPIGAAVQNLVNLHQGAAERHRRALSHARNANRKLPQWPVIFNGHNLAAEHGGHLSFIQSKIANPFISPLTPGILSEAQAQWLMETVWAQRAFLGAYTTAIITNKNNFRHVHTLRISKLSSGLLPSLEQREFWKSLSGLKRLEIYLSPDWRQEHVIGDKAFMHNMPISPAQAAERFTDFLRRYITKLENLHSLSIGYVGGGEHGVGMYARNQHVLPAPIVDNPNEWLLKNTSKTAPSLIKFDHVRELKFENCWFTPWMLKGFMEASRDTSLHCLTLESVSMTAIHEENLEMPLITVQHGLRCLHSREEWPREILPKGAAWARTLDAITPGKPLCEYRYEAGLLDRDDTPVPERSFRGHVQQIILNSCGYVKISLPTGRASTYNQNSAVIQSDCPMDRGLQVRRGRFSGLVANANADANGRLRERAPYVSELHDKTNRIMISSDGFPWLGTLTQCIHPIEKRVLEEAWQMNFGWGDDLSRWAAVEDGMFEGGTGRFGGVIKKDESAVLSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMX3</accession>
    <name>A0A1C1CMX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMX3"/>
    <dbReference type="STRING" id="86049.A0A1C1CMX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07390"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08716"/>
    <dbReference type="eggNOG" id="ENOG502SS5F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2832510at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32939" checksum="F3749BDC013DDFF4" modified="2016-11-02" version="1">MTESRQPSTEGAGTGPGLIYRPAEAQEDDLLSRILCNAFLPLWNHNWFHGVSHPLEPVTVGTVDSNPPMSRLQRSRVRFYLGLIKVTRLIGGIVLVAEVPPTATGTATAANSADATRATRDIGAILLWLPPSKRLGGLDIPTLWRSGLLSLMLPWHYGLTGFYRIDLVFEENIAKMWARTLPDLPPQGFKESDCGFVQMIARNPKYARKGYASGLLKYQMDQHFAEFPDRPVLLDTTTLEGIRAYERLGFKLLAETPVDTGTDAGGMKLTKDASEEVKKEAQEICVQRVMARLPGGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN23</accession>
    <name>A0A1C1CN23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN23"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07685"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08832"/>
    <dbReference type="OrthoDB" id="5316097at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="170" mass="18471" checksum="05F81B366F77C8AB" modified="2016-11-02" version="1">MSFHQLRRSALPILTALIGCGGLFIGIWSFVSPASAANAFGGYMVRVLQAQAQSSPTYESTQVSNSTPSSFAYVYPHGVRNLGQGLSILILTAYWQLSPRCQTSPLARLTVQRCLGVVITVGALTPVVDAWVNYRTAPEGLEGDLDRNAARVHTMRMVVWLVSGLWCLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPA6</accession>
    <name>A0A1C1CPA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beige/BEACH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_06522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPA6"/>
    <dbReference type="STRING" id="86049.A0A1C1CPA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06522"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05664"/>
    <dbReference type="eggNOG" id="KOG1786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000002">
        <property type="entry name" value="WD repeat and FYVE domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="1773"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="1944"/>
            <end position="2238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2370"/>
            <end position="2411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="905"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1644"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1644"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1735"/>
            <end position="1761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT50325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="2609" mass="292162" checksum="284ED3C0A03EC716" modified="2016-11-02" version="1">MGLTVNTHTRTRAVSTADVLRPEDKDIARLVKSLETLDRSSHSALQQSLEQSTCLQQLRHFLKDDSDLHGAHSGFRRAGGFQAVLGLLRCLVDSYSAPDDSLASIKFFLQTLSQLFGVLGAALEGHEGNQRYFRTKVDNGGWDALQSTLEDFFIILSSETGDELYLEQFFGVLFAVATGVEMINDIYTSVDRSTRSMKTEHESVLTDNTVASAQVGIVKALANVGELVVPELSTVILALWSTGIRAGKIPQRCLRVAVPLSLKELLSMSRHNIVAAHTAGAFSASLKLIFEEQLSATERSLFKEVALLLGQEGVSSLDDAHFLFKQASTSSDAASFLHSAIDVSRQPPSLQFDLSQHGYASTELGTLGRPFPPLDTPGYTLSLWARFDAFDPQAHTTLFGAFDRTQTCFVLAYLEKDTHHLILQTAIQGNRPSVRFKSVAFQHERWYHICIAHKRPRTTSSSKALLFVDGEFVEQQKANYPSTPPTDRGPNVKVQAFFGTPQDLSPNSAGVACLSKWSLGPAILFQDTISDDLISVFYHLGPKYHGNFQDCLGSFQTYEASAALNLRNELLHPGKEEQSELIMAIRHKASNLIREDKLLINISPATILDNDDRNNIDESQLIKSLSKVAAKNLIGYTRSGTNAVAINGAVPAINDALTQARGVLMLMGDPTVAVPQSLDDASWRLGGCGAVSLGLVQRARTTEDVALAVDILLETVQHSWRNSEVMERDGGYAILAMLLKEKLVLPTQNNGDSAKVGWAIPTSRLDRSGLSVRVLTSILAFTGYNSAELTKSVINNPLAYKVLLADTSLWRCGPVAVQQVYFEQFLVFAEHSEYKRFNLKRLTRMRVLKRLMEALKSEPVSRAIMPQYMAAIKTLLPQTLSAETLRSLALFVTFSVNKRNLGLHVRKPTRKEARQRSSSTGSSPGPKEESNLSHFEIGMEVLRLYSEMLCRKDDDGLIKKFAKTVTNKWLLYLLSETSPEVVVLSMRILARLLVVHGDTYVKKFKDSAKTSGFTVMAYRLKRWWHLPALWPALFAILFDLDVADLNLDRSFDLFNLVDLFASKKEISVVYPEILEVVMAMLQSGLKTIVSSKRHQAATSLAPPEDMSGPPERLSMSTMAPPNPLLTIVTSQHVSTFNTVVQFLADLHTRSQKFRDFAITSSYVQDLLAVLFPVVVGSNTVEAKTELDARDSMLTFDGGDVVVHPLSTNPPVVRTAADISSSATRGKTLGRGSSFVLVTKEHAHQNALLTVTAVPSSPTASSAIKKLPDLQEGNSIVQSLLEIVISVFMDQILVRKEFPGLGLFLKTPPGFVEHQTYFETWILRNTLSQLSNQIALDQKILTEPRVLINLARLFGHLEEALFEGWCIGGADPVLDLSGSILEYLQRPDVARLKPVRLCAQTIAIIRAVVFRTVVLSLSSIHDNDSLPFLAKLAYWQTVLLSGEETHSIHLQLICYLLYANLISSTDAVREAASNLWRIILVQKPDEAAAIFGQADNSEHKGLAGGFSKLVELDNETFLQWVDEHRNELDSLFFDTLSKQWNTFVTSENKRTEENGRMRIARRREKVKQWAREEADRDDLIRRHELAFENWTANIYSSEYLKHQRLLQDQQDDLLYTETSFHRMQRDTSRPAGLFAIDKPRKWRLDQTEGRNRMRMRLHEDFTYTEEDQQPKRKGSDMPQLRLDTRNTKMSTAESIGVTPGGATPLTETPSQVEPGSEPFPQLQEGTEQPADHEAGNEEQNEPVEGEESFELVEDPNADLDDFEDKNRKVMRSLHRGDQVKHVANISRILGLEAVEGLLILGKDYIYILDNFFQRADGEILNVWQAPQEERDPYVRMISGRDVTERKTVSRSDEHGTRSWKWSEIISVSKRRFLFRDVAIEIFFGDGRSYLLTVISPQIRNDLHGLISAKAPSPTGTGSPSETTWRYETLRSVDDEPQTLGSKFANVFSQQSSYLAATRKWQKGEMSNFHYLMLINTMAGRTYNDLTQYPVFPWVIADYTSEELDFTDPRTFRDLSKPMGCQTPEREREFRDRYQTFAEMGDSSTPAFHYGTHYSSAMIVTSYLVRLQPFVKSYLLLQGGTFDHADRMFFSIEGAWRSASRMNMTDVRELTPEFYYLPEFLVNINDFDFGTRQTSQSIGNVELPPWARGDPQIFIAKQREALESPHVSRNLHKWIDLIFGSKQKGEAAVDAVNVFHYLSYQGAKDLDSITDPMERLATIGIIHNFGQTPYQVFTKPHPAREQTRHRYKRLDTAAESLTRLPSTLLETGERVASLRFSWKSDRLLCSGPFRLNIPPDYETYLEWGFSDNSVRFYSTESRKQLGLFEHLHIGQLSCALFTDSQTLVTAGTDCTIAIWSAVESGKTIELHPRATLFGHRRTVSVLAISRSFNALLSASTDGQVMLWDLNRCEFIRKLGDGLPVQCAAINDVTGNIVLCHGHEISMYTLNGDLLLRQDSGDRSQDSIVSCACYEGAGNEWLERDLVFTGHKRGQVRIWSKVVRGGRFELELIRQLNHADSSRDDGANVGAGISCILPMAQVVYTGDEDGRVVSSPWYIPRSTANHDCSTNGTVCRGTNAVMGPEDGCSIHQRGVESIARCVGRAFMHTKDQALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPC8</accession>
    <name>A0A1C1CPC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07828"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="82" mass="8777" checksum="B171B942BF0515CB" modified="2016-11-02" version="1">MAGFSSDASKAEASFMWMKPPSDIVKPQGAAMRSRTRRPSPLGSFDLALSGSSEVPHVAPGSPRSDLAQRKSFNPSFPRGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPH5</accession>
    <name>A0A1C1CPH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPH5"/>
    <dbReference type="STRING" id="86049.A0A1C1CPH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07443"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05626"/>
    <dbReference type="eggNOG" id="ENOG502QS1J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="281" mass="31354" checksum="E9398049AD0605DA" modified="2016-11-02" version="1">MPPIPPLFVLPVPPTLSASSSAPGGQGSFICTQAAHQVYLLSFSCPPDNRLVPAFNQTFLLALDIIEHRLPRGVVITTSSISKFYSNGLDFENAIKDPTFFPNSLYPLWRRLITYPMPTIALMNGHAFAGGLMTAMMHDYRIMNPHKGFLCLNELDFGAALQPAMASVFRVKLSMTTFRNMVLESKRFPALEALKEGIIDGVGGVDETLKFIAEMKLTQKAQGRSYGQIKEELYREVVKDLDEAAETRGKLAARDLDRSRRDLEARKRVDDYQAVVQRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPP3</accession>
    <name>A0A1C1CPP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-actinin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ain1</name>
        <name evidence="8" type="ORF">CLCR_06810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPP3"/>
    <dbReference type="STRING" id="86049.A0A1C1CPP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06810"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05535"/>
    <dbReference type="eggNOG" id="KOG0035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071520">
        <property type="term" value="P:actomyosin contractile ring assembly actin filament bundle convergence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21291">
        <property type="entry name" value="CH_SpAIN1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000138">
        <property type="entry name" value="Alpha-actinin, sarcomeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000097">
        <property type="entry name" value="Alpha-actinin, sarcomeric (F-actin cross linking protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000279">
        <property type="entry name" value="Calponin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000223">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000030">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000077">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="11"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="125"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="485"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="639"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="665" mass="75720" checksum="CB40C245C294521A" modified="2016-11-02" version="1">MVHATIDADAFRPTYTDASRLNNKIKPREVAVRSLVTDLSDGIILIHLLEILSNESLGRYAANPRLRVQKFENVNKSLEFIKSRGIQMTNIGAEDVVDGNRKIILGLIWTLILRFTISDINEEGLTAKEGLLLWCQRKTACYEGVEVRDFSSSWNNGLAFCALLDIHRPDLIDFDTLDKSDHKGNMTLAFEIASREIGIPDLLDVEDVADVPKPDERSLMTYIAYWFHAFSAMERVENAGRRVEKFVSNMQGAWEMESAYEKRMRALLQQIRQQRQSWRDSQFQGTYADAKAQANALANFKRSQKRKWVAEKSDLSALLGNIKTKLSTYRLRPYQPPPELRLEVLDHEWAALGTDEHARSKLINETLRDIKNALRKTFADKANDFALTLNTLSLAVSGLEGDVEDQLNHAQRLADNLGPLEQYLGGIAILDEKCQEANIDENDYTTYTYDELLYELSLVKASVQKKLTFLENQMVARNMTNLTPIQLEEFESVFRHFDRDGTNALTELEFSAALASLGLVYDEHEMHDKFVEVCHSGIDPTMSPVSRRQRESRGVGFEQFIRFMVSVTEDQNSSEQVFQSFREVADGKPYVTEMDLRHSLIPDDLIEDLLSSMPEHTGPDLEADRNVPKYDYITFMQGMMGDGQHRDQPDQGRANGVATPTTPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPY1</accession>
    <name>A0A1C1CPY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cerato-ulmin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CU</name>
        <name evidence="4" type="ORF">CLCR_07723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cerato-ulmin hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPY1"/>
    <dbReference type="STRING" id="86049.A0A1C1CPY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07723"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05438"/>
    <dbReference type="eggNOG" id="ENOG502SZY0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4500971at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23508">
        <property type="entry name" value="hydrophobin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.120.10">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010636">
        <property type="entry name" value="Class_II_hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036686">
        <property type="entry name" value="Class_II_Hydrophobin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42341">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42341:SF1">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06766">
        <property type="entry name" value="Hydrophobin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101751">
        <property type="entry name" value="Hydrophobin II, HfbII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650964" evidence="3">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="102" mass="10162" checksum="DFD42ED2AA75C806" modified="2016-11-02" version="1">MHFSTVVVALAGASTALASAIPGKSSLMDRQAAVTLCTGASSSAVCCATDVLGVADLDCAPPPTPPTSLEDFTNICAAIGQQARCCLLPILEQGLICANPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ19</accession>
    <name>A0A1C1CQ19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hypercellular protein HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_06560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ19"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ19"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06560"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05451"/>
    <dbReference type="eggNOG" id="KOG1953">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="333"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="647"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="7">
        <location>
            <begin position="992"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="8">
        <location>
            <begin position="1199"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="793"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="810"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1345" mass="146017" checksum="B3A1EDC00DDAE2A4" modified="2016-11-02" version="1">MGYNPFLPIAGAKVNVLCIPAGPITPDRFQKFVKALQNAASIERKLVDSTPSSGLIFYDVSASQDKWRPHLFPFETNSRCQVVLGLVDGTRLLAASASGSREDEIPKHDILETVESIKVQFEEQQPFEPGLAVRRLIYCGGKVNAPLGGDVLSMPDLDGDEAARQVMITISRLLLEGLTAIVNDMKDQPISMVPGVNSSQAPRRTGTTPVASSGSSTPVSTKPSSPMPGANGAEQQSDTSRGRFNVIQGMFRVQCGSWINAMDALAEGAAVAQSGHDHLWHAKALEYLLNAMVLLTWSDMSFVVPQVCRSLPNRSGAFGGDVVPKSGDSLKILAQLLPPLVETILELYAKVANLDLGGSLQDVLRESRVRLVNLLVFVKRAGGLLTKQGLNQIVTGSDDGPDTSMQAKGEPVAVSKAGLANILIETLQEAQSSRSLLHHTCLLVAIATSLSVLGLDRKHAFYIKQLMQQFVPRLIEARKVGASEAGVHPAAGLPPVSAALQGIMPEMVAGTRTMLNLAAGTYGVPLPPVPPARQGIPAELTTIRERLRAWAIEHDTGDAMLKVEMLRACVSVCEALPDVPAGLHFSSNILRAARRVATMPKYSVNEVPLISAEEQARLLDSMRRAVSAASRLGSDGCRAEYWDDFLVRDIQVFERDGFSKLTAHKPSDLAIRGSALVDTVRDPFIYNPFSKDKSVVAAPVLVAGELSTFGVLLQNPLEVEIEIEEIRLLSEGCAFSPSAHSIVLGPMSSQPFTLSGTPTGSGDLEIIGCRATIRNCYEQDFLTFRDDWKPPVTPKQRVNSRARCRRGQITGENSEESAQLDSLSNPPVPTPLKLKVISAQPRLDIKSSSLGNPAMMLLEGESRVFDVTLINDSKTVPADLVLITAEDSVSERLKEALTTQELNPAEKYELQNQLAIHPAIEIKDKQHHDSKQILEPGTSIDYRVAVFGRPGLVSATVQADFAFLGTPSAEVRGTFYTRQVRFPVSVTVNGSVEIPRCNILPIHSDFSWGSGQSSGEEPAQDLSSAAANLRKLSRWLKTSSDAGQYCMLSLDLRNVWPQPLSIKLQARKPGAEPSDGLPWDDAYAVIETLQPGHVDRVILLVPRIFIADPHAPIPNLETQKQFVVTASKLSAEAETASRESFWYREELLKCLRGVWREEASGRHGEIDLRKGIRLSPRMVDALKVDHVEIEYTVKAHEQVPEAGKTDGVATVKQVGRAHFLVKTESFATLSVTIHNHSQETLRLILRLQPALRHQSQNVALDLSKRFAWTGVLQRSVHPAIEPGGVFVAQLGIIALVDGEYVVNASVEEVAGRRTTSSTKGTDAATAGTDRRIWHARSPCLIDATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ30</accession>
    <name>A0A1C1CQ30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BTB/POZ domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_06683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ30"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06683"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05390"/>
    <dbReference type="eggNOG" id="KOG0511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="684045at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18497">
        <property type="entry name" value="BACK_ABTB1_BPOZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000248">
        <property type="entry name" value="Ankyrin repeat and BTB/POZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044515">
        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="350"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="473"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="597"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="622"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="660"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="763" mass="85278" checksum="3D1112DDCFCEC1BC" modified="2016-11-02" version="1">MTANGLLRKDQLERNLFDERRLIEEGILKEDNPLDFSVNFQKLCDACRRGDLKVCQEMIQEGTNINAKDQYDYTPLILASLCGHYEVVQLLLESGALCERDTFQGERCLYNALNDRIRNLLLQYDYSKTTDPLQPLASHLVSLLTRDHPKTYDITVITASETFYLHKFILSARSPYFRSKLAQAPDTKVWKPAPTIPPQSFAIALKHLYLGEIPREPGGGPGTGFTDSEILAGVDRISKHLEIQNLSQLILDGNDRRLARQRRQDEVQRGRDQLERWFRDNVIKHAIEIETSRADDIKWDRNNGIFADILLRADEDEDEAEDEGDVPVPTNRDVQRQSSTNALGIPISHSDRSRSPSRTRKPRRSKIYPAHKAMLMRSEFFNTMFSSSFLEAQPTPHLQIVSIDCSPAVLEIILTFLYTEKADFGLDIAVDVLFAADMLFLEKVKAKAALVISSLGNGSAIAMPASTALSPEMVAQENVSQSQPPPPQPKDTPHDPSNSQPADDELDIYEILRAAWLTRVQRLEEFAARYIAYRLEAFIDTPEFAELVKESAERITRREETDSIELLDDIRYYLSERFRLRFEDSGLEDVMDEEAAMAEAVAQSQSQSQSQTQAQTEAQSESQERTKNGAEDAHAKPPQPLPRWGTDPKHPHEDEGVDMSASTSTATPTPTSTPSTALSSVLNPPSTSGAPSVPTAASAPSTDVDQDPNQNPDQQSIQALLASGAVRTLDGELAGDEFAAMAVDYQILLDKIDRLLEKLKLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ42</accession>
    <name>A0A1C1CQ42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C6 zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ42"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ42"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07423"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05410"/>
    <dbReference type="eggNOG" id="ENOG502QRM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5350673at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="318" mass="36131" checksum="CBCC152E36FCEBCD" modified="2016-11-02" version="1">MHHFTSVVALDLANSQTPEAQALWQVHAVKLGLKHEFLLRGILAVSAFHLAYLFPDRKAEYELIGTRHQSLGLTEFQETLAHVDETNCHALFAFSCLLIVLAFASSAKEKTEDFTRDVLHWFYLLRGANIVLNMHHETIRCSFLKPLLDEMAHMETTAAYRFPDTDQITKLFRVCNSPEHDKETAQAIDLAIHSLLSTFVQASLLKTRGEGTVLATFVWPINLPPRFLDLLSEKQPEAMVILAHYCVLIHWGESVKEDTWFISGWAEYMLETITESIPDVWHEQLDWPAMMITRAEEQPSGELTPVARNRSLTSMGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ48</accession>
    <name>A0A1C1CQ48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ48"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07748"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="110" mass="11684" checksum="744C0EE38E52DBDC" modified="2016-11-02" version="1">MDEQAYGMNLGQGPAPVLDTRQIGERLLDEGDQDGFEIYDCVTVGYGEGYAGSSDAKCLLCAGGEGGENRKKILVERERNIRFGGDQGCDVAVGRQQTGPGSRLIAALDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQC6</accession>
    <name>A0A1C1CQC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sad1/UNC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQC6"/>
    <dbReference type="STRING" id="86049.A0A1C1CQC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06634"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05342"/>
    <dbReference type="eggNOG" id="KOG1396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000082">
        <property type="entry name" value="Sad1/UNC domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650973" evidence="6">
        <location>
            <begin position="22"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="231"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="800"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="585"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="809"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="920" mass="100428" checksum="44ADD7643EBB7841" modified="2016-11-02" version="1">MWFLPLALVVLSFVRHGPVHAATSSRPTTSITPSTSPFRTVNHITHSLPQQCLASSRKANVTSTVAESIGSSKPDLDSTLLAETESPITVPSPTSSATDAALSTSHQPASLAAGPQEPSRSSFQPESPTVQSDTLPSETEEDSPLDDGKFMSFEDWKRENLRKAGQSEHIGKGPGVDSREPRKRPAGLRDSLDSLGDDGEIDLDFSGFVSDGLEPPTQSPARPSQDIRDGSADFEPGRLPKAGVRSKDAGTTCKERFNYASFDCAANVLKWNPEAKSPSAVLGENKDSYMLNECSAQNKFLILELCNDISIDTIVLANFEFFSSTFQTFRVSVSDKYPVKTDKWKTLGTFEARNSREVQAFLIENPVIWARYLRIEFLTHYGNEFYCPVSLVRVHGTTMLEDYKRDLEVLQMEEDDKANEDSIDTSAEDGLVPEAVAEQLLTQADAGETVARTVEANALAVPETFQPQTIPDITTQPSTVETLETAVPTCPAQLVPLFTESKTQSSTLGICNAFEHDAIMSDDPKMQDSIEGSSNAASTSTTGSVASANAEVSPSSIDNVTPVASNTTATTHKSDIAMDSKSYNASSSTPTTSTRTPVSSTQTTQPAPTMQESFFKSVQKRLQMLEANSSLSLQYIEDQSRALRDAFQKVEQRQLAKTTSFLEYLNMTVLNELREFRQQYDQLWQSTVIELDMQRERYQQENVAINARLGVLADEIIFQKRVSFLQLILIVVCLGLVLFSKGNLNSYLELPLVQSVLSRSPSARFLNAASPDTPNQSSPMSRSNATGAVRKRLGILKGHRRFPSEDSTENATSPVDLYTPSTPVSYGDPSSEGEILEDSNILGDPQFDPSLIERPSTSPPVLSGVDSPVSSDFDPNIEEDSIDSVLIGTPTNVMGRNAPILVVEDATPPPKHLKWQLPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQN5</accession>
    <name>A0A1C1CQN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fumarate reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_07062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQN5"/>
    <dbReference type="STRING" id="86049.A0A1C1CQN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07062"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05223"/>
    <dbReference type="eggNOG" id="KOG2404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006130">
        <property type="entry name" value="PRK08274.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF7">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="5">
        <location>
            <begin position="8"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="520" mass="56027" checksum="A41C88A45C97FB1B" modified="2016-11-02" version="1">MAPPQRCDVLVAGSGNAGFSAAVAAKQAGAKHVVLIDKCPEEWAGGNTYFTAGAYRTVHGGISDLLPLVNNVDDATAKKIDLEPYTNEDFSKDMKRICSGRSDPRLSKILIEESNATVKWLKGNGIRFQLSFNRQAYEVDGRLKFWGGLHLKTEDGGKGLIEDHKAAAKKHGVEVLYSTALKRLMTDSQTGAVTSVAVQSNGQEAVIETGAVILAAGGFEGNPRMRSQYLGPGWDLAKVRGTPHNTGDVLETAIRDVSAAQAGNWSGCHSVAWDANAPSDTGDREASNEFTKSGYPLGLMFNILGDRFVDEGIDLRNYTYAKFGRAILAQPGHVAYQVWDSRTISWLRSEEYRPERVERISADSIEELADKLTAHGLENKDAFTRNIREYNEAVYAFQKENPDKKWDPAVRDGMSTQSSTTRLSLGKTNWALPLDKAPFLAVAVTCGITFTFGGLKVNPETAQVISSATGKEVPGVYAVGEMLGGLFYENYPGGSGLTSGAVFGRRAGTAAAKAVAVATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQU3</accession>
    <name>A0A1C1CQU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="12">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="12">3-ketoreductase</shortName>
            <shortName evidence="12">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_08806</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="12"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQU3"/>
    <dbReference type="STRING" id="86049.A0A1C1CQU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08806"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09528"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141040">
        <property type="term" value="F:very-long-chain 3-oxoacyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT50884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="335" mass="35794" checksum="376C4A5FF18E433E" modified="2016-11-02" version="1">MNSTVDMGPLGQQSLLSTLLIGVGALTLATVVFTTARVLLSTFILPGRSLSSFGPKGSWAVITGASDGIGKEYALQLAKKGFNLVLVSRTASKLDSLSSQIRTASPDVSVETLAMDFSQNLDKDYAALGSLLREKKVAILINNVGQSHSIPIPFAETSLSEMTNIININCLGTLRATQTVLPSMLPQKKGLILTMGSFGGLTPTPLLATYSGSKAFLQHWSNAMASELAPSGIEVFFVHSYLVTSSMSKIRRANWQVPTEQAFVKSTLAKIGRRGGSVGYPYSGSPYWSHALVAAVVTGVVGPMNSLLLGYNRSMHVAIRRRALRKAERDAQKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR29</accession>
    <name>A0A1C1CR29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tip elongation protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_08033</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR29"/>
    <dbReference type="STRING" id="86049.A0A1C1CR29"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08033"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09599"/>
    <dbReference type="eggNOG" id="KOG0971">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="8">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="493"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="572"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="684"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="735"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="521"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="828" mass="88673" checksum="404258D6AC6A4A30" modified="2016-11-02" version="1">MANINIGDTVMVPGDMYGTVKFIGPVAGKKGTFAGVQLATEYAGRGKNSGEVDGKHYFRTTIPGSGIFLPLEKAVKKPGSAGGGGGAGLGLSGVRASPGPGTPTNRLASFNQGGRTPGAGTTGMAKPGFSQSIGPGAMRPSGAASPGLKPPPRRESLPRPSSPLRKVNTPTPRGLATPKARPSGIGLAKSTNGGAVGGPYARPGQRNNFSQSLRQGSSAPAASPSLGPESSFDEIPEHEAEFTPTPTPNFSRKPGAEADSEKYEAKIRELNEELAEARRQLRDQSTNFVEMERNFNEIQKLMPSLEEGKQTRQGEEDEEDLPRDIVSLRDALREKNDKIKLLTAEFDANRADFRSTIDTLEMASTETERVYEKRVDELLEEVRNLQDRSEDVETVAQQLKQLEELVQELEEGLEDARRGEAEARGEVEFLRGEVERSRSELRRERERMKTEEQLNGGGGYSSSSDVQALEAQIMAKDDEIRGLKVIIQNLNAASPKRPNGASSGMGNGHQRNDSTAAEDALQKQICDLEQLLQQKSAHEEELVQEVKQLRNSVTLSKFPMPVGGAAFGLHTAMRSPHSRGNSDDLDRKHLSTGTVGSQRTVVLGAKNNGGTGHERKDSQPMGPESWHDAPSRGASPTQHHHGERERSDDGVTDVSTCESAVLWCEICEEGGHDILTCSNMFGPGKKASTSKNSSPRKAGKEAPSGQFEEEPSSGVDLDRPAPLMSRKFTNNTIASHINSASNPPPEEDLPAPPHQADDPGRPESPPPVDEPMAAAAPPSAPSKLVEGTGAQAGMLAGRTTGVIDPEKWCALCEKDGHDSVDCPVEEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRS8</accession>
    <name>A0A1C1CRS8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dsk1</name>
        <name evidence="12" type="ORF">CLCR_08174</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRS8"/>
    <dbReference type="STRING" id="86049.A0A1C1CRS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08174"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06865"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000409">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000076">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="107"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="264"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="339"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT51210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="592" mass="65334" checksum="90320A80B455983E" modified="2016-11-02" version="1">MMNGTDLKKAAINQAKKVATTAALAANGNGQKKRRKGDNLKPIITTDSAASSSLHDSPTQAEPESPSSSTSEDDPAETTADEEDSEDYCKGGYHPVHVGETYNNGKYVVVRKLGWGHFSTVWLSRDTATGKHVALKVVRSAAHYTETAIDEIKLLNKVVQANPNHPGRRYVVSLLDSFEHKGPNGVHVCMVFEVLGENLLGLIKRWNHRGIPMPLVKQITKQVLLGLDYLHRECGIIHTDLKPENVLIEIGDVEQIVKAFVKDEKEPTKDDNRNGRRRRRTLITGSQPLPSPLNASFTNLDKVGGHGHHQPSSLNQVINDSVSNKSAEGLSMLEQLKMKSKENKPNEEQTASGKTREGTTDPLEKDLAGVSLDSKKSTDAEKVLKAAKNEDDPVGEIISVKIADLGNACWVGHHFTNDIQTRQYRSPEVILGAKWGASTDVWSMACMVFELITGDYLFDPQSGTKYGKDDDHIAQIIELLGPFPKSLCLSGKWSQEIFNRKGELRNIHRLRHWALPDVLREKYHFSVEEAKKIGDFLTPMLELPPEARANAGGMSNSEFLKGVKGMENVNLDIPPGSKGEGIEGWACEVKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRV9</accession>
    <name>A0A1C1CRV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_08348</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRV9"/>
    <dbReference type="STRING" id="86049.A0A1C1CRV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08348"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06834"/>
    <dbReference type="eggNOG" id="KOG3908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249838at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002099">
        <property type="term" value="P:tRNA wobble guanine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="21"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="6">
        <location>
            <begin position="256"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="6">
        <location>
            <begin position="280"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="403" mass="44131" checksum="7972992F0E85A992" modified="2016-11-02" version="1">MSTASKPSALTFDLHGRCSTSKARASTLHLPHGAVELPIFMPVATQASLKGLTPEQLEETGCRLCLNNTYHLGLKPGQAVLDTIGGAHKLQGWNYNILTDSGGFQMVSLLKLAKITEEGVRFLSPHDGSPMLLTPEHSMSLQNSIGSDIMMQLDDVIQTTSPDRARMKEAMERSIRWLDRCIVAHKYPETQNLFCIIQGGLDLEMRRQCCVEMVKRDTPGIAIGGLSGGEAKTDFCKVVDTCTSLLPEKKPRYVMGIGYPEDIVVAVALGADMFDCVWPTRTARFGNAITSRGVLNLKHARYAEDFGPIEEGCSCTCCRAKQDGGLGVSRAYIYHLAAKETVGAHLLTMHNVHHLLSLMGRIRTAILEDQYPAFCKDFFAGYFEGQPPPEWAVDALKGVGIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRX4</accession>
    <name>A0A1C1CRX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative C2H2 transcription factor (Con7)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRX4"/>
    <dbReference type="STRING" id="86049.A0A1C1CRX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08752"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06843"/>
    <dbReference type="eggNOG" id="ENOG502S48N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1939603at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="287" mass="31988" checksum="4C6ABE797B537D2D" modified="2016-11-02" version="1">MAQPTSPSKSLPEGAPNGNPNTSSHHVRSNSDVPIDPSISQASPTYPPYSPYPQGQDMQHAYQPQHPPYMQQRPPHEQWGGYPPQHGMPGPYPHPGPGVQGPPQTSAASRSGQVYSFVPIPGAQQHKRPRRRYEEIERMYKCGWNGCEKAYGTLNHLNAHVTMQSHGTKRTPEEFKEIRKEWKARKKEEENARKAEEERHRAAAQASQVDPPADAHQVPGQGYQQNGARPSLPPIGYQTPDSHAQGQYAQPQGGMVYPQGNGQMGSYPNYPNSPYGQQGQVYQQRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSF5</accession>
    <name>A0A1C1CSF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Developmental regulator flbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">flbA</name>
        <name evidence="5" type="ORF">CLCR_08143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSF5"/>
    <dbReference type="STRING" id="86049.A0A1C1CSF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08143"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06652"/>
    <dbReference type="eggNOG" id="KOG3589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="377"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="501"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="704" mass="78341" checksum="B480FE48F45AC66D" modified="2016-11-02" version="1">MSDSNDVTIDEPMTSATPPNLPAQVIVSSTAQDTPTIVTSPRTDQARPPHHHHSSSTSLTQSKSRRSLASLAREKTSSAFANLASLGTNSTPSLRSATSSGSLSKQSSSSGGLRPTLPRSPTSPEVQVAAQSRRTSGVPPLASQDLRHSLATALSMPNPDRRDGKMHQTSSKILRMTDDERPFTRDFQDLFATLITSLPLTPHRVRFSRVEETFLSEEAITNLGSLKFSQSNRIPDPKNPSRWVVTTTTTTFSMAKEMARSVCQRFVDARLIESAESKTNTAFVTKGGVWQLTPKGSATLYRFCSRNGINARHIEPILRRSQMQMVSLERDPATDKLVQDRPTIEIIFRRFMGSEGPNLKSSTSLSDSDSVSEYATGLVGIKMAKERRVLDKLVNNTFTGKAASDWLLDCCTTIDRRETYEMAELFVKWQLMVPVVEDRAYVRANPMATYFQPTKHAIYTITERGQRVCGWLARPPSIDSEDSRDIKDPKSRLAKDSNVNRLNVILQDAALRLLFKEFLRQSLCEENLQFYFDVSDFTSNYRALEKAGKLDRPDAVRETLAAAYGKCVDGLVRTALIDLGLYNSFLASGAPSELNIDHSLRNRLDSRMIRTNTDEESMRGSLEEVVELFELAQNVVFKLMASVSFSGLLLGIWSTNHVQDSVPKFLRDPRHAAVLRDHEIDLIGSNRTLSPGPERTVSRSNTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSH7</accession>
    <name>A0A1C1CSH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSH7"/>
    <dbReference type="STRING" id="86049.A0A1C1CSH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08890"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06626"/>
    <dbReference type="eggNOG" id="ENOG502SQ3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3145928at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="314" mass="35583" checksum="1A57B43789C1FD91" modified="2016-11-02" version="1">MSQTQMSKLKDPTLYEFVTAFFSRKTVLMGPLGRPIPLEWNIHPAKKTLLPLMESSLAVLKEAKAHLESLMYQAYEVVRVGHLLYHDGYEMQKLKPRQELHLKAVQQWKDMFHQLCIDGQFSEMGCIVSTLFMYWGMCYIWLAACTSPLQTSFDKHMDDFEAIVDNAQVVLQCNAASSKEGQVLTSDGDVVPPLLFTATKCRDPILRRKALQLLRQAPYRNSLWSSVASPILVEKMIAVEEGDTHFATYPVSSPPVGLPPEERRIHHYAIVKGGASDGHRRLKAQLTKAALDTNGSLRMVHEEVWVEERTENSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTA6</accession>
    <name>A0A1C1CTA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_07910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTA6"/>
    <dbReference type="STRING" id="86049.A0A1C1CTA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07910"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06365"/>
    <dbReference type="eggNOG" id="KOG0988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057503">
        <property type="entry name" value="PH_RdRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF17">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25358">
        <property type="entry name" value="PH_fung_RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RdRP-like PH" evidence="4">
        <location>
            <begin position="133"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="434"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="966"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="976"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1192" mass="133753" checksum="629979803B147478" modified="2016-11-02" version="1">MEVFIKGIPESLTQNQFEKFIRSPLSDLGIYDWQVQKRPRNQFANLIFLNISDGQRFLDSHGQAKDLSGREYPPASRTNIVCFGVPLSCSLSKKQPDPLALRSLQMESKARPASKRSTGQSQIGSHSGAERRVLKIVSLSCGTWGYHGSKTVFSPYTHWPTRGTLKFVRKRAIISSDQGSRVDIPLTSIVETNTEGLPHPAITLTLNAAPLFFETASSSASAASDLDNIITILGNLGNNRRNYQDPHWTRIPSLNSQHETVAGTCLVYRINLEGSTVDHQMTAMGRTRQVLSPLQQHVEVVEPQKPYKAEMNALLERLEGVNTTRSPASLPFNVKFQLQALVQNAVLPPSTISGLLGDIDAMITRTGPQICAYAIRRLSHELPSRCLQTDFENAGLFAARNILRAAEARVREGGLLPEEMQNLGGRAHIHRVTFTPAGMYLYGPEPVNHNRVLRKYYENHDAFIRVQFCDENGDPIHYSAYWSNDTIYYSRFKKILNEGFHVAGRRYAFLGFSHSSLRAQSCWFMAPFIHDGSLLYDRQLIRGLGDFSRMRCPAKCAARIGQAFSETPIAVTVTEGVAQVIDDIERNGRVFSDGVGTISKILLEKIWAAMPVEGKVKPCVFQIRYSGAKGMISWDPRLTGEKMLLRKSMVKFFAPGSLDIEICDAAYRPLPYFLNQQTIKILEDMGVDESFFFFHQNKELDRLQSTTSSPTRASQFLKAHSIGDIIHLPWFIRQLSKMKISFLHDTFLANVIEMAVMMELRALKYKARIPVKDGYTLRGIMDETGLLQEGQIFCIVEEGGLPKVIAGENLVISRSPALHPGDVRSHGSRDLPSQLSGGDLDGDLYQILFDPKARPKRLFEPADYPREEPIDLGRPVRREDMTDFFITFMATDQLGRIANQHKFLADQRDDGTLDPDCIKLAGLHSTAVDYSKSGIAVDLTKLPRSNHFRPDFMAPGPHVVIEKAKPLNFAAPPESRDDDDDDDEDRPAYRYYESDKVLGKLFRAIDEYKILSTVQSAARAERLHFAQQPQSVLKAVWGNVYQRCQFVKWREHVPRAVGIRDEYESIVHDFAVDYGTSYSQPLSEYEIFIGNIMGRAGAQSKTQRENSQSLRESFRDALRYIVGRILKDEGVESEHALERSVACLAVGLETSNSATVKGPLKEVLVSFGYVAASVCLWELDRRVVVSGDVLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTL6</accession>
    <name>A0A1C1CTL6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative formin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_08910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTL6"/>
    <dbReference type="STRING" id="86049.A0A1C1CTL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08910"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06275"/>
    <dbReference type="eggNOG" id="KOG0150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="290" mass="32459" checksum="BB0C3C1FB5465121" modified="2016-11-02" version="1">MSEYWKSTPKYWCKHCSTYVKDTPFERKQHENTAKHQNNLKRFLRDIQNNHERGEREKERAKSEVQRLKGIATDDTNKSSSSSYSVSKPTPSVHRPATGPPAIADRKRQWAQLAEMGIKVPEEFRPEVAMAGDWQTLSQQVVGEAPLSTGVKKRRYEGQEDDQEEKEAAGEAVVRRGWGATTKTYPGQDDPDLDDLLSGSIPVKTEKSGSQIKGESGMSMKQERHPALTQDESVAGNHTSPTVEACSGDNPMTPKVVEEEPGATQTPLLKDQALEEVSMPVFKRRRPKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTS8</accession>
    <name>A0A1C1CTS8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08112"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06219"/>
    <dbReference type="eggNOG" id="ENOG502RZ6G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="332"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="704" mass="79496" checksum="FB112B7CE466AFA2" modified="2016-11-02" version="1">MGQPASSAIGREKETKSMARASVRQNERFTDTRVRDLAESLLQIEELKTKNSMLLDALKTIAASPNLDSTETGNIREMILNCELEVQGTPSMTPSTRTADSSRFPPSVESSPEDEQYTDASLGSPVGQDVLTHSIDVGRGRGAVGFIGKISEVSWIARAYSYLISPAAEDFAMREKISNHIPATQFNYFMDDEDLLSLDEDYVDALHWPGDLTARILCEAFFHALHGNFNCLARGRVLEELDKFPHNRMQLSWDQRRWLAVANLMWAIGSKWLHHAMLDDEPGMESHLVYYARARALGLDHRVMLDNPGLHGINALGLLSFYLFTNGSVSRAWSLIGLAIRNATCLGLHLRAIDRALSQVQLEERARLWFSLYSLEVAMSEVLGKPPLTSLEYTTVPVELLKSASVKDSPSDTETDDTRRLWLDFLRRRRDASQTMRGGQVPWQNFQFIGYGPPLQHISSRARLSIISNRVMTQLYMPKLSHSWSSMQKIITGLSIQLVGWENSLPEELNLKSTIAMGTDPRAKIDLALYHQSIRMILYRPCLCHIRIPNESDYSREFNLSGARSCVRAGVTMVDILPEDASAHEAYQLLPWWNLLHYIGQALGVFILELCLDMEHFDGVAAHLTPQVRKAMSYLWCLTAGSLSAYKAWRIFRHMLWILSLRVDSFDVVDILLEAHIPTGWTVNDEARLMDTLRPIGDEPMMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU35</accession>
    <name>A0A1C1CU35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1295 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU35"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08722"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06112"/>
    <dbReference type="eggNOG" id="KOG4650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="201504at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41557" checksum="2DFF75744918BB7C" modified="2016-11-02" version="1">MALPTVQSLKQCADYNTTVAPFLYQFATLPEAFFTSASSSAGLKQLYLDTNPLMTSVGFAFALAPVFLVVSEVNKNYSQVDRVWSILPTIYNLHYAVYSHLAGVHTERLDALLVISTLWSSRLTYNYFRKGGYSIGSEDYRWAIVKEYVGPTLMFLFNVVFISLAQSLLLVSVTTPAYILLLTERLATYDGPIKSWSFVDTTASGLMLMLIAISFVADQQQWDYHQAKAQYQRTARVPHGWRRADLDRGFLTNGLFAYSRHPNFAAEQGVWVTLYLWSCLATETVYNLSGLGAAAYLLLFQSSTWLTELLSARKYPEYNDYQRQVGKFLPIPGYTHPTFHHHHPQHANGSAAKEEDAAKARQRYDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU86</accession>
    <name>A0A1C1CU86_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BNA2</name>
        <name evidence="7" type="ORF">CLCR_08504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU86"/>
    <dbReference type="STRING" id="86049.A0A1C1CU86"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08504"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06079"/>
    <dbReference type="eggNOG" id="ENOG502RZ6X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF10">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT52055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="468" mass="52307" checksum="D4D2FE4CE3B5B89B" modified="2016-11-02" version="1">MRERLEDFLHRYGVSPRKGFLPDGEPLRRLCDPYYEPWEDLVADLPRHILDERARWKIDELPILDPARLISQAEWRRAYVILGFLTHAYIWGGEEPSERLPPQLTCPFLAVSEHLGLPPTATFSTLSLWNFRLESPDKDPIKAENLRSLLSFTDTGDEEWFYMISTAIEAKGAPLISTMLRCIEAVDANNDCVVLSGLRSITSGIQDIGKLLQRMHERCDPQVFYHNVRPFCAGTKGMAAAGLPRGVFYDQGKGQGQWRQYSGGSNAQSSLIQLFDIFLSVDHNTPGRQEPSQPTSVVARVRAKGYLQVGHAIKRPASGASFQVDSNPLQEMRDYMPKPHRDFLSAVEQSSNVRDYVLTNATTLSAELVAAYNDAVAALANLRNIHIQIVARYIVMPSRSPPAPYIASRKWKNLATACSKKSAEEADGNTSMTRQLHGTGGTSVMPFLKKTRDETARTTIPADCTTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUE3</accession>
    <name>A0A1C1CUE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUE3"/>
    <dbReference type="STRING" id="86049.A0A1C1CUE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08449"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06027"/>
    <dbReference type="eggNOG" id="KOG4462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2430277at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="486" mass="47520" checksum="BE84AC45408E5FCF" modified="2016-11-02" version="1">MPAPPPPPPPPPPPPPGMGGPPPPPPLPGNSLPAAPPKAVAKGRDALLSDITKGARLKKATTNDRSAPLVGKVSGGGGGPVAGAPPVPGGLKAPSGLAPPVPGGANRARSHSDAGRDSTASLDGPPQLAGLLAGGIPKLRKTRGGVETGAGVDGAHSDSETSTPGPPRPPVAAPPRLPSMPAPPIPGFRPPLPGSVDSAPAVPSPLANLKKPPPKPLSKPSSVASLAAGKPPPPPPASRKVSAAAPPPSAPPPPPSSFSSVPPAPPPPPPPPSISPAPPAPPPPPPPAASPSFAPPPPPPPSASPAPPAPPPPPLPSSSAPSLAPPPPPPPPPSLPPSAPTGPPSRSTPPPPPPPGPPPPPSHPPTTNGVGSSLAQRAAATAFGRQPSYQPPDAPPSPSSPISPPASRRVSQIPSRPGLDPSSYTLTNGGSFGLSSGSGGPIRIEDNRWKFQDESQLPPPRQFTGVQKRYRAGRGSTVPLDLASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUU8</accession>
    <name>A0A1C1CUU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09201"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05884"/>
    <dbReference type="OrthoDB" id="4156372at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="170" mass="18584" checksum="A3683856AAE33D3E" modified="2016-11-02" version="1">MTRFNWNTNTTHSEASTSSESTEHHHHHHESKLSHVMDSIRHALAHEHERLPSDSAAQEQLPQRQDAAGSTKGSISPALQAVASSKLNENNMGEDSHQSDKTWGWPGLGTFKTHDSATSQRSKSRSGSAGSEAHMEEKVEAATFEAIDNAAESETYGWPGLGSWTTSPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV73</accession>
    <name>A0A1C1CV73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV73"/>
    <dbReference type="STRING" id="86049.A0A1C1CV73"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10548"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03812"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="321" mass="36140" checksum="4B5ACE98E2E8C4FB" modified="2016-11-02" version="1">MVKSPTELSALDANLEKHQTLHRLAFEVEVQRCMAKYHDSLVGGAENSVYETLVQMCEQELNNLVDRYHSSMDAYLALHVDTARLHLYTLAMLRMKSGLGETEHANARGQIIRYQKLGMLTAHRVIDIYCDSLQSPDTRLIDVYRALPKQFFIGILHATFFLLRYFVLNPACEGEVKAESRNKVLMIHAKLKASTSHQLAEPGRAAAVIEVLCRHGGEQASDTSEDIYDRGVASISWSALISAANLRGKRNLKTTWLQKINPASPDLRSDHQQSTTPEPVSQGNSNLEFVEQDYPIPDDIWDQSFLQMLDFSAYDLDNSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV99</accession>
    <name>A0A1C1CV99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab15, 13, 10, 1, 35, 5, and</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_11010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV99"/>
    <dbReference type="STRING" id="86049.A0A1C1CV99"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11010"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03808"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="109" mass="11853" checksum="913054A91BC7F546" modified="2016-11-02" version="1">MDSFNNVKQWLQEIDRYATEGVNKLLVGNKSDMSDKKVVEYTMAKEFADSLGIPFLETSAKNASNVEQAFLTMARQIKERMGTTTVNNKPTVQVGQGQGVQSGAAGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW11</accession>
    <name>A0A1C1CW11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10984"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651150" evidence="1">
        <location>
            <begin position="24"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="140" mass="14239" checksum="CCFD28E1EC97402F" modified="2016-11-02" version="1">MKGVTDSVLLLFLALGPQRLVKADFLSDASVAFASATSAIIHNPADVLDIYSSLTSRYGPVPVDATGSAASEFAPITSLMGAIATDPADGVPNLISNILSEEVLATSILNETLNANDGRVIFRGVAGVLGAAIAALIAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWR4</accession>
    <name>A0A1C1CWR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10671"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04332"/>
    <dbReference type="eggNOG" id="ENOG502SIDW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5169850at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31301" checksum="D0F8806FE928AB38" modified="2016-11-02" version="1">MTKLSAATPTNPTNLPARYEIRRLTEEHLPFALAIVLHSNVFYSPVWPIVYPENKTARVYEAFPAAEYLIRHQIESGHSFGVFDLEYEFRRAESKPDGKLYWDMQDTTLDADQLLAQMDFPLVSVALAYDGINPLDMGSVMPLIACLPLFGTFYHVLETLDPRPEASWKPTAEKQLLLRNATSTRHDAEGKGLMKALAQFLMRYAHEEGFRAIQIECFADAVTKVWSEPPPPFKSTVVSEFNTAELEEEEEVDGVKRKVKPYGDNCRQRATKIIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX85</accession>
    <name>A0A1C1CX85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DNA repair protein rhp54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">rhp54</name>
        <name evidence="15" type="ORF">CLCR_09618</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX85"/>
    <dbReference type="STRING" id="86049.A0A1C1CX85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09618"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04427"/>
    <dbReference type="eggNOG" id="KOG0390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="229"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="562"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT53095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="805" mass="90560" checksum="D075177F67DDA969" modified="2016-11-02" version="1">MLIRTKSIAVDHDKENIPPAKAGRLSVNSPAALDRLIKPFRCPGSANARKSKGEPARKRRKVNYAEESAGNDDTSGGFSLDPESRALKDRYPVFKVKDKESIFRSRFSVPLINKNAFDPSRPAPSLGMRRGVGFVNKPLHDPSGEFAIVLYDPTIDEKPPDRSEEKKDEDKPKLDTPLMHKSLAEILGIKKQVEGERPKVPVVIDPRLAKVLRPHQVEGVKFLYRCTTGLVDEKAKGCIMADEMGLGKTLQCITLMWTLLKQSPEAGKSTIQKCIIACPASLVKNWANELVKWLGEGAITPFAIDGKATKEELTMQLKQWAMATGRGIARPVLIVSYESLRLNIDELKDVKLGLMLCDEGHRLKNADSETYMALTGLNVERRVILSGTPIQNDLTEYYALLDFANPGYLGTKADFRKKFELPILRGRDAAGSDTDKQKGEQANAELGSLVKKFIIRRTNDILSKYLPVKYEHVVFCNLAPFQKDLYNHFIQSPDIKSLLRGKGSQPLKAIGILKKLCNHPDLLDLEKDLPGSEKFWPDDYVPKEARGRDRDVKSWHSGKFAVLERMLARIRQDTNDKIVLISNYTQTLDVFEKLCRARSYGCLRLDGTMNVNKRQKLVDKFNDPNGEEFVFLLSSKAGGCGINLIGANRLVLFDPDWNPAADQQALARVWRDGQKKDCFVYRFMSTGTIEEKVFQRQSHKQALSSTVVDSAEDVERHFTLDSLRELFQFKPDTTSDTHDTFKCKRCKPDGTQTIKAPAMLYGDTSSWNHFVNSGEKGPLNRIQDLLLRQETTEDAVSAVFQYISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXI4</accession>
    <name>A0A1C1CXI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phosphopentothenoylcysteine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXI4"/>
    <dbReference type="STRING" id="86049.A0A1C1CXI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09954"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00158"/>
    <dbReference type="eggNOG" id="KOG0672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70387at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="580" mass="65845" checksum="6F24578664A3D0D5" modified="2016-11-02" version="1">MGAPTRSRPSRRRVNALLYVTEKIGPEVLPYLLQNPDLNLRVISECSKAEFQQYMDPSVDLEDVQWIENRPQDPYRNHVMMQGHRLSRWADLLFIVMDAGMISLMLSGFTTDAILHVLRCWDVSKRIALLPEMSVDQWKHPTWKRQLNKLQRKWDWVHVLSPALWDYAADPADFTQPGPNPLGHDSEPEIEWQWQGPGDIIEEVESEAQAVLRSTQLKTNSSMSHLPIHKSASSKPSLPSEIWTMILDYLGDWELATALGIYTHLSVPHEWESLVPKPGSKARSLEYTILTQPLPLIQKYFANTSSNPPTTLSPIATRLIFRFSMTDLLTYLALQQKDIFWTSFGLALLPHKASLIYNSPTILQWWKDCPAVIKKEYGPEAMDGASRAGFVEVLDWWLNSGLKLTYTEKALESASAKGHVEVLEWWRVNSQKLAGTDREIHLKVGKSILLAAQSGRTNSIEWWETSGIPYAHEDGVARLASQHGHVPVLEMWFGFKGNKMIFDNQVLVGATKNGHAGVLQWWKEMSRKSGLRVEYKTCDIEEAMEDAVGGGGEGEVREWWGRNGLNLGVGTGEWMRVKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXL1</accession>
    <name>A0A1C1CXL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">U2af50</name>
        <name evidence="11" type="ORF">CLCR_09815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXL1"/>
    <dbReference type="STRING" id="86049.A0A1C1CXL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09815"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00219"/>
    <dbReference type="eggNOG" id="KOG0120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="237"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="356"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="464"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="54"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT53259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="563" mass="63065" checksum="AF9F1101981C1BFD" modified="2016-11-02" version="1">MNGDNYSSRDSGRSREHHSSRYDRDDRRDRDRDRNRDRGERRRSRSPHHRSSRRDHEDSYASSRDYRAREREDRYGSRRDDREWDRDRGPRRRDDDRAPRRDRDLFDDRRGGGGGPGAGGGRDRDRDRSGREDRDEFAAQARGQKNSPPPKKREPTPDLTDVVPILERKRRLTQWDIKPPGYENVTAEQAKMSGMFPLPGAPRQQQMDPSRLQAFMNQPAGGATSTALKPSNSRQAKRLFVSNLPTTVTEESLMGFFNLQLNGLNVVKTVDPCVQVNIAEDHSFALVEFRNPSDATTALAMDGITMEEHHTEMNGNGDTNPKGLAVKRPKDYIVPTADDDAYTDGELSTEVPDTANKLAVTNLPPFLTDDQVLELLKAFGELRAFVLVRDSDAPESRGIAFCEYSDPSVTAVAIEGLNGMDLAGNAIKVTHASIGFTQAAGLEMGVNAMSMFAGTTSDNMEDGRVLQLLNMVTPEELIDNDDYEEICEDVQEECQKYGTILAMKIPRPSMGSRQSAGVGKIFIKYETAESAKKALQALAGRKFADRTVVTTYFDEASFDVNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXY8</accession>
    <name>A0A1C1CXY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Biotin carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">accC</name>
        <name evidence="11" type="ORF">CLCR_09789</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXY8"/>
    <dbReference type="STRING" id="86049.A0A1C1CXY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09789"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00299"/>
    <dbReference type="eggNOG" id="KOG0369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007:SF1">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="10">
        <location>
            <begin position="11"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="130"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="573"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="468"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT53331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="667" mass="72553" checksum="4B21DCAB9731F83C" modified="2016-11-02" version="1">MPPPPAPPQRPITRILVANRGEIAIRILQSCHELPNRPTTFALYTDNDSTHVSLGRPHHAIKAPSPASYMNIDYLIGVAKQNHVDAVHPGYGFLSESAEFSRRMWTEAGCMVVGPGWEVLERTGDKLMAKTLAAECGVPVLRAMDRPTGSVQDVRSFAEQAGYPLMIKAVDGGGGRGIRLVRSDDALENAVQRCVGESPSRLVFAEQAAVDGYKHIEIQIIGDGRGRVKHLWERDCSVQRRFQKIVEVAPAPVHGRTVVAQVIESAVRMATQLKYLGLGTWEYLVNVQQAKFFFLEINPRLQVEHTITECVTGVDLVKEQLLLAQGIQDPENIPSGNADKAPHSASIQLRLCAEDPLAGFSLSIGKVTDVQFPTGNGVRIDSHLSRGGVVGSDFDNMMAKIIVTSSTFGDCIVKARRALEETKVAGVKTNLNLLKAILADDTFASGEADTRWLETNLDRLVQSGEQLASTTDRLDSSIPTLSPGSSHASAGAPSATPFRKGDAWTVVLEDPRNTSPATAKPPAHHLAIERVTRNEFPEALIADVSYTIPGQQPQSYKMTLNSTTASADATASTHRRGDPGNKAHIILPMSGKLVEVLVEEGDEVRENEVIAFVKQMKMELEVRSPRAGVVKWAIELENEEGDDVAEGTLLVELEAESVQKPEIRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY08</accession>
    <name>A0A1C1CY08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative dual specificity protein phosphatase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY08"/>
    <dbReference type="STRING" id="86049.A0A1C1CY08"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10537"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00354"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140096">
        <property type="term" value="F:catalytic activity, acting on a protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="158"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="324" mass="36128" checksum="16977AA9330B0C89" modified="2016-11-02" version="1">MASWAEGHSSRYVAAQGYSDKRRLEAPRVNVPPPDLNYRNGKPTFRVHGLPYNRTSRQYGNHEFLRALVSSHRFDLAHSMLTWQYEMRRNAQAILPFLFLGPSSVARDPAFICDTGITLLVAARSGKSVRTRKTFLDPATFASSAGIASWTFDFDHPAEFISLVKPVIRAINDHLEATCARTPIRDIHDVRGKVLIFCESGNDRSALLVAAYLMVVYGVEAIAAIHMIQSQRFCITLSDDMKNILLDLQTITTAERQVSDADAAMMPFIMPSNDDGSVASRPRRPSKRNIDEFYTSDDEKGNGVGQLMETDIREGVAPFVDVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYA6</accession>
    <name>A0A1C1CYA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF636 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_10853</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYA6"/>
    <dbReference type="STRING" id="86049.A0A1C1CYA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10853"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00490"/>
    <dbReference type="eggNOG" id="ENOG502SC1H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2212170at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT53524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="148" mass="15560" checksum="43B067906DCAD911" modified="2016-11-02" version="1">MPTGSCFCGNIKVEYSGDPAMTALCHCADCRKISGGNYSNNIVVPSANFKVTQGTPKEITKTADSGKSITSCFCPDCAARARATGTTLFRYGDSFGGIDGMRIIKAGILDDVNVLNQTKPGAELYAPERIKWVAALEGAGQIDAMPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYK7</accession>
    <name>A0A1C1CYK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ser/thr protein phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYK7"/>
    <dbReference type="STRING" id="86049.A0A1C1CYK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10544"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00496"/>
    <dbReference type="eggNOG" id="ENOG502QPJI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052963">
        <property type="entry name" value="Pantetheine_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36492:SF2">
        <property type="entry name" value="[ACYL-CARRIER-PROTEIN] PHOSPHODIESTERASE PPTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="322" mass="37170" checksum="A7F8A6B1D41A7E26" modified="2016-11-02" version="1">MTKLYAIADLHLSYKHNRDALDELRPHPEDSLIVCGDVGEKLEHLQDAFRITTKLFKQVFWVPGNHELYTLPGRGDRTDGHEDDALNKELRGELKYEECVRVANEYGVITPEDEYVKWEGEGGPCIICPLFTLYDYSFRPDDVSRAEALDWAMEENIVATDEALLHPDPYESRDQWCEELVAKAEERLGATSRRGIPLVLVNHWPLREDTITIPTIPRFSLWCGTKKTEDWHTRYNAKVVVTGHLHVRRTDWRDGVRFEEVSLGYPRQWQMAKDRGLDINDLLREVLPATDMVDPGDGSTLWRRSGRPSKALERTTSTQPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ57</accession>
    <name>A0A1C1CZ57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SPC19</name>
        <name evidence="15" type="ORF">CLCR_10901</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ57"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ57"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10901"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00749"/>
    <dbReference type="eggNOG" id="ENOG502SDEQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3361333at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT53824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="174" mass="19760" checksum="5B36A66F64C04D59" modified="2016-11-02" version="1">MATLGPAVSSLRSSLSLLESSISILDEGVSDFPRLCKVLQTQQHFELLPEPTLQEAQQSLVDEIVPAINQLLSTAENYINQLGRKEENLKARSELLEGRLHNNRRRTSSFGSNTEVLRSGKSAQSATPLSDARMLEMKRLQQKKERLQYAIERLELQSKQRERELRKSMAIVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZN9</accession>
    <name>A0A1C1CZN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cenp-O kinetochore centromere component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_10386</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-O/MCM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZN9"/>
    <dbReference type="STRING" id="86049.A0A1C1CZN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10386"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00765"/>
    <dbReference type="eggNOG" id="ENOG502SCC4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10050372at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018464">
        <property type="entry name" value="CENP-O"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14582:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14582">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT MAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09496">
        <property type="entry name" value="CENP-O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="213"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT53840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="42671" checksum="52E58952B660088D" modified="2016-11-02" version="1">MSNLLDDEIAQVRAEIQALTQQRKLLTSSLLSSTQVQSRLSNASPSTTTYPQQNDDTPLNIDHVQEHNQTNIHRLALGVTAFPFIDPSPELQAKNPLLGIRIDVCTRHGKFDSPYYIFCVRSTDRGQDLRIHRHTIPALVPLEQYEREYLPLSSLNREEDEGYVGSDGVENGAGGARKQDLHILVSRVRYDLVSWRLRKDAAEWLREELGLSRQSRNEGRSNGRDSADSTGGERAKRRDRARSNSDHGDDDDSDPDTEMTDSDSDSDELTGKFNVDSLTTLEVDARQLRIIWSDDRVGRLKVSDDGKIEKAVVIGEDGTRVRDVERILMGDEKEGCSVKELLKRLETVYTKSKERKVPETAATRTNAPMTVGGKRKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZP4</accession>
    <name>A0A1C1CZP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yaf9</name>
        <name evidence="8" type="ORF">CLCR_10748</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZP4"/>
    <dbReference type="STRING" id="86049.A0A1C1CZP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10748"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00884"/>
    <dbReference type="eggNOG" id="KOG3149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16908">
        <property type="entry name" value="YEATS_Yaf9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="7">
        <location>
            <begin position="9"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="245" mass="27988" checksum="53B4DDE0B1B5FC9A" modified="2016-11-02" version="1">MPAPSGVKRVRGVQIHRPFIYGTEAIPFDPDNRPKDAPPDHTHKWKVFVRGINNEDISYWLRKVQFKLHDTYANSVRMIESPPFEVEETGWGEFEIAIKFYFAPESTEKPQQIWHGLKLHPYHGDIEAQKRDRSMISSVCYEEVLFNEPVEAFYDILTGGTQVVKSKAGKGGKGMVKAPPTAEIPLRSSAGNKFSREEESKELDRLGEAVKQVQRLIAEEKAKLTKEEARLQELEKTEGKPIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZR1</accession>
    <name>A0A1C1CZR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative urease accessory protein UreF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZR1"/>
    <dbReference type="STRING" id="86049.A0A1C1CZR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10579"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00940"/>
    <dbReference type="eggNOG" id="ENOG502REVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2550922at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT54043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="315" mass="34012" checksum="A4CF18AA737295C0" modified="2016-11-02" version="1">MNTNGHDEGAVLTARVLELEAELRSTRAQLNSVESSGSKVMTEVPSNGSLEAVSLPISLSLDSSIHNLMLLSDSALPLGSFAYSSGLESFLAHHKASGAKETNLALFHKFLKLSIQSMAYTNIPYALAAFRDPMALSGLDNDLDASTPCNVARRASVAQGRALLSVWERAFLATAKHGHRGHDMDEVAATALNIFARDLKISSITAAPLEIPSVNGHFAPLWGTVCLALRLSLADSAYVFLLNHAKAVVSAAVRASVMGPYMAQTVLASRELQGLIRECLQKVWWLSTEEAGQVVPMLDLWIGRHELLYSRIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZX1</accession>
    <name>A0A1C1CZX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Retinol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_10018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZX1"/>
    <dbReference type="STRING" id="86049.A0A1C1CZX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10018"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00954"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT54057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="552" mass="59698" checksum="4B803B6E5886D15F" modified="2016-11-02" version="1">MDIRPAANASCKAPRCLTPSPPNPGDFGPTGCIGSMTVETCETQGSCWDALLGALFSQSEPRDSEHTNDHEESKVHKKGIRLGARYPRRLYIRPRYVVAILPTDEAGDTGIRLWNRCAPGPSALCPASAHLTRRRLGREAIPLIHTSIKHQISHFGKCACYTPASFPPYSEPTQTTPATPALWVFCNPQAAAPLAFPIIMPTDFGFETEGLAVAAAFPSSIKDRTILITGANRKGIGYSTAESFASQSPKTLILAGRSTEKLQECIDDLKSVYPTVDYRPLKVDLSSQQSVRAAANEVLSWTDMPTIDIVINNAGIMNIPTRTITADGVELTMATNHVGHFLLTNLILPKVIAAAADKTSPKGTVRIVNLASAGVAVTGVRFSDLTYEKPASEMPKPDEYPNIAMMQAFDLPVDDSTTYFPTIAYGASKTAAVLFSVALNDKLYDRYGILSFAVNPGEIRTELGRNTEPQLLSTMLAKAAAHGMKWKTQQQGCSTSVRAAVDPSLGLPAEDGMGAFMSDCRPKPAPEYATKKELASKLWDVSEAWTGEKFDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0J8</accession>
    <name>A0A1C1D0J8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0J8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00326"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="196" mass="21225" checksum="CD59C66ED7303402" modified="2016-11-02" version="1">MAILPTPTFLKDAIPLNDCTGYIGIVIPDASQDTGVPKMPTSDQPGAPGSRQFPRTVDGPLAHARYGLAAAGMDHGQDDGDHQRDVPQRNVQQQVDTQHGAVKAGFDVNKFDLEDPQTWPEGFDPDTFNPKAKAGMPHDFDENDPMWKQWLEKAITQFNDRSKKVQAQVAGGGTDSETAKKTDMIQPDGTRVATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D125</accession>
    <name>A0A1C1D125_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D125"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01016"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="81" mass="9264" checksum="FCC6618C344EC3EF" modified="2016-11-02" version="1">MSKIKFHRYGSTFNCSINKGATITKMSSTFDSQHRDGPDPEQAKEKVDKTSWLDDLVPPFDSPRSRGVQTYRRQQLRQGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D144</accession>
    <name>A0A1C1D144_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">1-aminocyclopropane-1-carboxylate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acdS</name>
        <name evidence="9" type="ORF">CLCR_00869</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16933"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58360"/>
            <dbReference type="EC" id="3.5.99.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D144"/>
    <dbReference type="STRING" id="86049.A0A1C1D144"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00869"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01688"/>
    <dbReference type="eggNOG" id="ENOG502QPS1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266364at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008660">
        <property type="term" value="F:1-aminocyclopropane-1-carboxylate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019148">
        <property type="term" value="F:D-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009310">
        <property type="term" value="P:amine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06449">
        <property type="entry name" value="ACCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000048">
        <property type="entry name" value="1-aminocyclopropane-1-carboxylate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005965">
        <property type="entry name" value="ACP_carboxylate_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01274">
        <property type="entry name" value="ACC_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780:SF2">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="8">
        <location>
            <begin position="29"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="367" mass="39302" checksum="465BC29F303B3425" modified="2016-11-02" version="1">MAAMKSDFRNADDLGLPEPFASIPRYPLTLGPSPIHALPNISAALGAKVTIYAKREDLNSALAFGGNKTRKLEYLVPDALAQNCDTLVSIGGYQSNHTRQVAAVAAKLGLKCKLVQEKWVDHDDAGYDKVGNIQLSRLMSADVRLDQSGFGIQHKQTLKKLEEEVLARGGKPYYIPAGASDHPLGGLGFARWAFEVHAQERQLNVFFDTIIVCAVTGSTLAGIIAGFKLLERTHGPAPAPASPGGKKRKIIGIDASAKPKETFDQVLRIARQTAAKVGLDESDVAESDVVLDARYHAGTYGLADEATLAAIRFGATTEAFITDPVYEGKSLAGLIDLVKRGEINEGSHVLYAHLGGQLALNAYSEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D170</accession>
    <name>A0A1C1D170_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D170"/>
    <dbReference type="STRING" id="86049.A0A1C1D170"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00886"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01704"/>
    <dbReference type="eggNOG" id="ENOG502RQIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="373" mass="42306" checksum="AD8FD63959A097BB" modified="2016-11-02" version="1">MALAVFSRTQHLAAAATEAREKYDQLLRTAQVALPNLVHRDVDAALLAIFLMSRYEDSMHTPDEVQSTTAFKSYYHHDGATVVLKIWHENSVKIMQPASDIIKHSRRGIIRSFLLRQMAVPVWLANGAQFGECGLELEYDQLLVRVANLRHQLKHIQQERLLHDRRSQEVYWRARALNTEADTLNKALQDWSSRLPSTWCPQRHLIPAHVSLPRDHCFSSIVYTYSSVAYAPVWLNYFATMMLLNRARLRILEITRPSSDDLAGEQQREEEDCCLQIREMADALSSSIPFALERFAVAPASKTAEQQECILREDEEIKPYHGNLTAWPLSVASSIGGLDGGMRDWLKAELVLVGKTVGAGVLECAQSDDWLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D184</accession>
    <name>A0A1C1D184_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein SVP26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SVP26</name>
        <name evidence="7" type="ORF">CLCR_00933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D184"/>
    <dbReference type="STRING" id="86049.A0A1C1D184"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00933"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01746"/>
    <dbReference type="eggNOG" id="KOG4136">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28257at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097020">
        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144:SF0">
        <property type="entry name" value="PROTEIN TEX261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="TEX261 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="249" mass="27598" checksum="9C780E7A2176AE74" modified="2016-11-02" version="1">MWILPLLGYAGLVLGFAFLTLSIASGLYYLSELVEEHSVFSAKLLKRLIYAVIATQLLLWLVDGFPWHLILLGVGSHAVYATNLRHFPIVKLSDPFFLSSCALVILNHWLWFRHFSDTTNRGGGFRGAPPSSRRDWYSTPVYDQPTFTEIASYFGLCVWLVPFALFVSLSAGENVLPSMGSEYATGDRQGVGFQKGHKRKNTGMAKAAVHATREWVTDTGAVMGLWTSDNVPPSRGFGKGHTRINSVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1R0</accession>
    <name>A0A1C1D1R0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetolactate synthase small subunit, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ILV6</name>
        <name evidence="8" type="ORF">CLCR_03006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1R0"/>
    <dbReference type="STRING" id="86049.A0A1C1D1R0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03006"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04735"/>
    <dbReference type="eggNOG" id="KOG2663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2013116at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000001">
        <property type="entry name" value="Acetolactate synthase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053050">
        <property type="entry name" value="ALS_regulatory_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242:SF2">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="94"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="351" mass="38405" checksum="7B210307D0673B68" modified="2016-11-02" version="1">MAGRRNLLSLAYKASSQSTRTRTGTSFLDSVLPASRRSKSTNSTSALAYKALHRRSPLPLPVSDTSPQYGAAAAVSSILYETPVASTAPPKKHILNCLVQNEPGVLSRVSGILAARGFNIDSLVVCNTEVEDLSRMTIVLKGQDGVVEQARRQLEDLVPVWAVLDYTSAALVQRELLLAKISILGPEVYEELMEHHREMTSPESEHTAADLEDAEENADKRLQELEENKPEESSLVQRAKEMLGQGDSYHPSRLAASQALRHKHEHLEAITHLTHQFGGKVLDISTNNCIVEVSAKPSRIDSFMKLIAPFGILESTRTGLMALPRSPLYDPNEELVRDADDVVDASTLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2H6</accession>
    <name>A0A1C1D2H6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2H6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03154"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04931"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="148" mass="15580" checksum="286273446DC8C7A2" modified="2016-11-02" version="1">MGKDLPSENDLPLLIEDDSSALKAPDPIAASTADVADETMLSAYEASFRPPSVVASQILAGAGAAINGLFITRPLILTPECRHSGSADLAKDIMPSTYGDSFRARSVTASEILAGAGAAFSGIFITRPLRLTPECRDPSKVIGQRFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C663</accession>
    <name>A0A1C1C663_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA-splicing factor SPF27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BCAS2</name>
        <name evidence="9" type="ORF">CLCR_00138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C663"/>
    <dbReference type="STRING" id="86049.A0A1C1C663"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00138"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02032"/>
    <dbReference type="eggNOG" id="KOG3096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="202" mass="22643" checksum="6914E4B3339CD401" modified="2016-11-02" version="1">MLTAAIPDIDPEITDTERQKAKALISRHLPNNHTTAPHPSLAPLPAVNLSDIFRQEVDRVAAGEPRRQGIDVSRYEAPDEPAIESDEATMREALRNAYISSTFLSDRQANLELLDEFGKNAWLIGNSQTEEILQGLERELAGLRSEAENVNKARKAVQEQSKAELLTLQENWKRGIGKILEIQVATDRLHRQTLEPQRRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C678</accession>
    <name>A0A1C1C678_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_00084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C678"/>
    <dbReference type="STRING" id="86049.A0A1C1C678"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00084"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02028"/>
    <dbReference type="eggNOG" id="ENOG502QT79">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5284003at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="739" mass="82828" checksum="2D0E0E824D9914E7" modified="2016-11-02" version="1">MASISQSSAYPSVQPQDTNSAYKYEDPTAYQIPSGYPANQFEVPLPVPRAEPEPQPKEPSRAQGTPSSEPKVRLRKACDSCSVRKVKCDESGPPCKSCAALEIPCTFDRPSRRRGPPNRHAEAIKRQKLDGGSFDAARSSPTHDAAYSLASLSTPIPLSAESICDLHTVKILLDDYFTYIHPLIPLPHEPTFRRSFEAREDRTNHNFLALLAAMVECLVASFPRRPRQLFTAEPGKSQFPNAGALIDRCHQVFVEARGLGYMDRPMNLYDGIASYLTGLAAGYTLDIPRMRLYLGECTIIMRELQFHRPEIHRPSQTPATPYGPGDMPRYPLVDHIYQESGRRLFWLLFVGAMSARQLDEAEGDLLMPPVSHAEMLPPLPVEVDDEFITEAQIFPQPRGVVSEMVGFNLNVKVFRAFHFLAALEMAFGANNVYDWDRQRQIIRRALQTVKDATRDAPKELQLNPANGFGEWPPTQADISAYSHLFNDRDGADAESLQTPGSTRGSFSLPSKRAIQFEIQKANIYATQLSSRSYLVERFWNLYEIVDRDKLTFPSDKSVTSSSPTAGIVTTGMEHSYRQMAGRTPSDSVMDAGEQMMAVEREDIVRDMALLLKSINQVNMEPNGMSFVSSYRLDAPSGKANRESQCNKIRTIASTLLETKRARMSVMPTLDSEGVNAYLHVFLDILSKLERLGPGRFRGVADNNTGGLLQTPEEIEEEELVHWASLKEHQERFVRSNGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6C3</accession>
    <name>A0A1C1C6C3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6C3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00104"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02030"/>
    <dbReference type="OrthoDB" id="4139190at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="484" mass="53688" checksum="3AC77759FD97F380" modified="2016-11-02" version="1">MARGQASVRTIQDLAIDRALRDLEAQPRLNYQQVYQRVVRHYVDQVVTEGMPHFWISRLNLEVELARVIIVATRSPEEYTRDYLATLQELGDSMRTHRARDYRAVWLAELLRAGITLDDVTVVHEDTDEYERRTEFRDWVHEWVHGTLHDGTLGDFGPTVATGNYIAGGSSSSGPGANVTVSTGCSQVIPSAPGPSQPTAAGHDTSMPPPSATRRPTSNRLRSANNPVGGASSSRCASAARPSRGNASANPLTVRVSGGRTTFAMNTAGGLVDFAEHQRGQRCPWTCLLGDSFVTNERGRLTGHLQRDHQLRAADLAHMLVDKPNASNFEGHLNKDCFAWAKYVHGDPRPWKCMLCENHRGMKDGQNTLARHVRQSHGIQIVLPRVDERQPGRRHLSGTTEEELARRVEAAQRAEQQRAADAAAQEAAMKVGLRLTLIGTKRSALDAGLDEEEGEEDVEVEEVVEEEEEEEEEEENDEEAEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6J9</accession>
    <name>A0A1C1C6J9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_00726</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6J9"/>
    <dbReference type="STRING" id="86049.A0A1C1C6J9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00726"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01096"/>
    <dbReference type="OrthoDB" id="4505108at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF17">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="14467" checksum="81A1DD961D04A7C1" modified="2016-11-02" version="1">MARRFPVHVRDVGMSFATATTWCFNFILSFTWPHLLTAFKPQGAFAWYGAWCIILWCLILLFVPETKALTLEELDQVFGVSTRKHMSYQMKNAVWHFRVWVLRQKLEPLPPFYRRAEKLNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6M0</accession>
    <name>A0A1C1C6M0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6M0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00685"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01054"/>
    <dbReference type="OrthoDB" id="5596743at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058645">
        <property type="entry name" value="NTF2-like_dom_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26534">
        <property type="entry name" value="NTF2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650603" description="NTF2-like domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="NTF2-like" evidence="3">
        <location>
            <begin position="97"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="270" mass="27710" checksum="BFC6CF67B54D91C1" modified="2016-11-02" version="1">MKSLLFAVFASVPFVAANPWGSNPFMKERGVCAADNCARAVTGTNAPQPLATRQADCAAFFSPLPTPTVPSYASACSGSTRYSSACSCLGVARPTYTCLSAAQAENIVKTFSSLLTAPQAPDFVSKATTLLADDFKDNSDSINFLAGYPLGATTFPSKQAFIAGQGSQPPIPTVTTLEIFNTCNKIAWRWVAKGIGSAQYDVKGIDTFTINPSGQISEVNVEFNSGAWAANLAGLGGAPPSSGASSSSTTASTTPAASTTTTPAAAPSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C743</accession>
    <name>A0A1C1C743_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor TFIID, 31kD subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_06227</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C743"/>
    <dbReference type="STRING" id="86049.A0A1C1C743"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06227"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06984"/>
    <dbReference type="eggNOG" id="KOG3334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000069">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="265" mass="28903" checksum="7D612B47D2F67D04" modified="2016-11-02" version="1">MSSPANPPGPLTPPAEPATQPSQPTQATQATAQPPVEALLSQPLTSLSDDGSSRRPRDHRLIHLLLASHGISAYQQRVPLQLMDFAYRYTSSVLSDALYIQNEAYDQADGGAQAKGRGSKQNQNKTEEGDISIGALRMAIGSRMGYQFQASLPKEFLKQLADDRNRISLQAQTRDGDKSGPLVGGVRLPHEKYCLTGVGWGLKDEWDSEGEESLAEPEAQERPEPEDVMQMDEREHDAELEGEGTMEDVFGPSEDKDADGDVELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7C4</accession>
    <name>A0A1C1C7C4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7C4"/>
    <dbReference type="STRING" id="86049.A0A1C1C7C4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06362"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07064"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF4">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19382" checksum="3ECAB60A05AB5345" modified="2016-11-02" version="1">MCLPAAIRVAYAKAKVGFVFSRRGIIMEACSSYFLPRLIGHSRALHLTTTGAVYPAESPLFGTLFSELLPSPEATLARALELADEVAKNTSTVSTKMMRELMYRGADSAEGAHLLDSRIIHGLFGSKDNVEGVQSFLQKRQVNFTGQVPQDAPDGYPWWNQIDIGQKSADPRGKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7E7</accession>
    <name>A0A1C1C7E7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_05357</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7E7"/>
    <dbReference type="STRING" id="86049.A0A1C1C7E7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05357"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07086"/>
    <dbReference type="eggNOG" id="KOG1038">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000041">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="13">
        <location>
            <begin position="351"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1341"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT44392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1424" mass="159865" checksum="3E55E9ED1611DD2A" modified="2016-11-02" version="1">MLRTRATASSRYALSYAEQAAGRIQLPWLCPVLAQPHHSERHHRTITTRPTISRSKTLPAPVTQSRHLASPAAVPDSFDRGDDYIPFAYRHSDHSLTRDPRLPQNADLSPFDLSQILMLDAAELPEDSIDTHGGAIRNIDEIEATLDACLQVHRWDRAFALLSQLSLFCQHNPVRLRNSFNRVLAALVDDLIWNRNGEHEKRINEWIEVHMRKADLEPDAHTFALKLKAALETLIGSKRDRTVRRYWDMTKRYALESRVLGMREVLDDRDLGRLSEICTLDVATPRLESTTITFRPDASALPEASDKEEAHIRETEQKGLGLSSLRQSLSLFSEQTRNATDSTPTEDHLAQRQRRLERDAIQSALDRWKTEFQKRARMGVMPTDLAYGEIGALLWQWHEMLAEKIRHEIKLAREEDLLPGTKTAQQKLRAECTPFLELLQPEHVAAITSIALMQIMSKFGATKSIKLVKLVTALGQLLEHEYNATTTNQRKSAFYKAARKAAKGQGGLGPFLEAAESMETHLYRRSSHHAAKPFMYSPGWTKAIHGKIGAVLCELMFDTAKITVRRLDPTTGAMLSMPQPVFLHSTAYSNGKRVGVVSLHEDFVKILVTQPAEHLIAKQLPMVCPPKPWKSFRDGGYLESKQPFLRIKHNETAQKDYAIAAASRGDLDQLFAGVDVLGQTGWRINKNVFTVMLEAWNSGEEVANLPPLNKVFPDIDRPGENASPRDRWEWFSKMRAVDNEKSGLHSNRCFQNFQMEIAKAYLDETFYLPHNIDFRGRAYPIPPYLNQMGADNCRGLLLFDKGRELGAEGLRWLKIHLSNVYGYDKASLSDRAQFPMDHLSDIYDSVRNPLSGRRWWLGAEDPWQCLATCFELTNALDSPDPSKFMSRLPIHQDGSCNGLQHYAALGGDIAGARQVNLEPGEKPADVYTGVCELVKAEIKEDAANGDELAKALDGRVTRKVVKQTVMTNVYGVTFLGAIRQVRKQVESLIPEIEAAGQSGKAATYIARKIFKGLGALFSGAHEIQYWLGDCANRISSSISPAQQEKIYEDVFLSKHEAKASAGARRTNTKGKEVLESGTFRSPVIWTTPLKLPVVQPYRINKGQRIRTNLQSIMLAQPSAADSVNKRKQLQAFPPNFIHSLDATHMILSALKANEVGLSFSAVHDSFWTHAADVDTLNVLLRDAFIRMHSDDIVGRLAAEFNKRYDGHYYLAQINRNNALGRAIASYRRELVKAGVYPKGSGAKAVQQQRHVELAREVRKKKLMASEDPAERQEGQEMITAATLYEKHNGDRYLSTRDSLGETAIGMVPESAEIADEGVLDKALNSSEVASDIDLAGTLDPLRDSVANDHDEDAVDAGDHHSASDPSSSSHDINVFGQKVRKPKEQNKQGQNHQMWLWLPIKFRPVPQKGDFDVKRLKDSVYFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7V9</accession>
    <name>A0A1C1C7V9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U2 small nuclear ribonucleoprotein A'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lea1</name>
        <name evidence="7" type="ORF">CLCR_06162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7V9"/>
    <dbReference type="STRING" id="86049.A0A1C1C7V9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06162"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07266"/>
    <dbReference type="eggNOG" id="KOG1644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="229" mass="25331" checksum="B456EA53C6705CC9" modified="2016-11-02" version="1">MRLTAELIHNSLSYLNPLKERELDLRGHKIPTIENLGVAGSQDAIDFTDNDITTLTNFPLSPRLNTLLCARNRIQNVDKRIAEQLPNLTTLVLTNNHVRELADLEGLSGCGALTHLSLLENPVTKKEKVKDVERKQTQELFGTAEAPTELAAKIKGVKSRTFDVSSVGANGEAARSQKGVRTKLTESEKRRVEHMIQNAKSFQEIERIEKDLAEGRIPAGAADADRMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C811</accession>
    <name>A0A1C1C811_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C811"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06339"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT44617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="119" mass="13663" checksum="B39B99367421677D" modified="2016-11-02" version="1">MSILGEEIRATRRLLVAVEDVKQESATSWVENVMNSILSAFDVDGGYQSYQHDDPDFDFRQEIEQFPPCRSSFRTSLHYSSAQNPASHLLGFLRDEMNPVVFDWREIQCEKLRSGFANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8B8</accession>
    <name>A0A1C1C8B8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8B8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05788"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07389"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="500" mass="55095" checksum="545BA0648B0A20B7" modified="2016-11-02" version="1">MPEITIRGCLTSLGFHYPSTLYKSVKRDITAFLRASVDLPYASDELLRHTADRYLTHTQSYQASASWDPTITKLLHWATEEKRTEKQDLICDVMKLMQRNALETIHKKPCTGCRNHPQPITSASATTTTITAPATISVRQSPLSNMSAPPVPWLASDVERDGIASGLPLPEEQLSHESTRSPHSPSRRSDSISSVLPWADDPYDSDYTDARPPRKRKRVPATSHVRSSLPQPPVDQGEAVAPEMQGTILVAPSPRATATPGLDQQQRRPSEVKDPQPQASKAKDTQQEQRRSEAKETQQEQQTSAQAKDPEELQQTAVQAKAPQAPIGPDVSASASASASTSASSPPSSLELRGRRWVFGTAAEKIKGLEAARARQHALLESFVQERGDDSQVKSVAAMLSHHSKTLDMCLTQAAQHSKTLDMWLTQAAGRDWEAATLVSAGRDWEAETLVSVLTRQLDIGEWLLREICGDDKALLRKRIWELDSQTEKCFVENGGDPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8F8</accession>
    <name>A0A1C1C8F8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_06356</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8F8"/>
    <dbReference type="STRING" id="86049.A0A1C1C8F8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06356"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07474"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT44800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="84" mass="8983" checksum="75C61556FA97E883" modified="2016-11-02" version="1">MSPTLDKIDTNPPPSASRHKTTMTPTATKPLSEEETKAFKDVFAVFDKDGSGTITAQELGEIMKSLGQNPSDSELQDMVSPASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8X0</accession>
    <name>A0A1C1C8X0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8X0"/>
    <dbReference type="STRING" id="86049.A0A1C1C8X0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05483"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07578"/>
    <dbReference type="eggNOG" id="ENOG502S0CM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="833" mass="93065" checksum="845D01549C94CED2" modified="2016-11-02" version="1">MTDMSGQGCGHAVRDELEQSSTSAATRFHPFDLEYPELPLHLSLDSLLAHSSSSNPSPTRTVMPPPEADQPPLDGSWASLVGDESSNEEDLQSEHTDVGSLLDVHSSDDVRSVTDEVTTDDAESTDEDDLGDTLTEELDRGHILGPYIRHELPVHARSSDSLQSLQCSENNVQKIIPRTVTTFTASKELTEAEIQTLPSFQRGETKSTTYFRVIEMPVLEDGLDLNKHNHFNVLLLGRQIEQFRPEIQRKVGDALVTRFGTTSYTNPTSVTRFLLVPNAFGPGAEPDFADLVAIDKQIDFDCYDLVTASRQPGQQTELILTNSQTGTKLISKRSGSGFVVDNQHWALPDLAIICVHLSDEDTMDVDSFRMISFAERHRIPYILIRMNRGWHGQYNGVVTIGSLHERIEPQHIQPEHKGSPLLPVDMAAFLNLDSAQLNRHIAYVVMSAERAARREVESQNSLPKIAVEKPMTIVDVIPRLSPSILKNALMLLWVVGVYVFLGYQLWPVLSGLNSGGSNREVVSSASTEPPVPATTMHPPCQESPSTSCIPGQETQALRHIPGVSSTNVDPVLADDSRRFRVSIAGDKQLVVKLPEVALSHKARSKLTVELRRDTQKLPAAVQELFDGVVSVQLLPHDAYGDIEVNLTMSRPELIEIVKVSFGDRYHFEGQHLKDLLSMLQGHVQAKVSNISSSLQDIGRGLFSDRLPTLLRLAKDRLDERRRRDGTQYTKLVDLNMTILRYRFHQKMQYLRDQMVQRNRECFMQGRMLLDVVSTKYSDARSRILNTVESVNQRRVRPRLDHAIVADKLETARGRAHRLVSRAARNLQARNAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C956</accession>
    <name>A0A1C1C956_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GATA factor SREP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SREP</name>
        <name evidence="12" type="ORF">CLCR_05818</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C956"/>
    <dbReference type="STRING" id="86049.A0A1C1C956"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05818"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07655"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034757">
        <property type="term" value="P:negative regulation of iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000039">
        <property type="entry name" value="Siderophore transcription factor SreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF335">
        <property type="entry name" value="IRON-SENSING TRANSCRIPTIONAL REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="94"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="265"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="131"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="218"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="319"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="409"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="412"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT44982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="470" mass="49791" checksum="C65988AEA0C95882" modified="2016-11-02" version="1">MLAVRSAMDPLHHSSSLGSEQDSLMRQPSAEDLDAAHQLVSSALGERHVSHATNDNHVNLATDNPSPRQVSPRPERPEPQRSPSETTEPREDASGLAQVCSNCGTTKTPLWRRSPTGHTICNACGLYLKTRNAPRPTNSRRQTSVTPGETPRQRITASPAGSAPSTPAQPQSSTIPYRLPEHTSGTCPGGGECNGAGGAEGCGGCPAYNNRVARSSMASALASQQPEDGASDAQSDAGSSTAHGASNPSPQPQAAPGGVALVVACKNCGTTVTPLWRRDEQGHPICNACGLYHKLHGSHRPVQMKKSTIKRRKRVVPAYPDAPRPATQQPASASPEPTASAAEEHQVSSDSSPALKRRRQPPTVDYTGYVPQSSLSEGPPTSQDTSDQYAINLQRAAAAAGGMQLDPALLEAGRRRQEQDATHSEARADGAGSEEERGALRAERRAQLMREAEVMRAALRAKEREIDDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C993</accession>
    <name>A0A1C1C993_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF323 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_05434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C993"/>
    <dbReference type="STRING" id="86049.A0A1C1C993"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05434"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07772"/>
    <dbReference type="eggNOG" id="ENOG502QS9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052706">
        <property type="term" value="F:L-histidine N(alpha)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903257">
        <property type="term" value="P:selenoneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="5">
        <location>
            <begin position="29"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="550"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="740"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="703"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT45105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="846" mass="95172" checksum="7A8E428A09B5D2BF" modified="2016-11-02" version="1">MATHTAAGVPMLDIREDTSNKSLVETLKQSLNPPQGHPRTFPTLLLYDEKGLKLFEEITYLDEYYLTNAEIEALKLHAEEIVARIPEGSRLVELGSGNLRKVNILLEAFERAHKKVEYFALDLSLSELKRTFAELDTSAFRYVSFHALHGTYDDALVWLGQHRADRAATCVLTMGSSLGNFTREGATQFLASFKKALTASDFVLVGLDACQQPERVFCAYNDSRRVTEQFYRNGLVHANNILGYEAFKPDDWAVEGLYDEKSNKHQASYVALKTIRVKDFTFEKGEKIHLEDAFKYSEAESDALWHAAGLILQMSYGNEANNYHIHLLSPSSIDFPVKPAEFAASPIPSQNDWRQLWAAWDTVTKSMVPRDELLNKPIKLRNDLIFYLGHIPTFADIHYTKATATEPTDPAFYRSIFERGVDPDVDNPELCHDHSEIPDAWPPSKEILNYSERVRARIVESTASGLAYSDRKLGRALWLAYEHEAMHLETFLYMLLQSERILPPPGQAPPDFRALAAEARAQRVENQWHRVPASKVKLGLDDPEHDLGPDRYFGWDNERPSRNVTVHEFEAQSRPISNGEYAHFLEVTLKSPLPASWTTVDTSGQSNGTNGVNGHAKDTLKMASSAFVEGKAVRTVYGLVPLKYALDWPVMASYDELAAYAEWSGGRIPTLEEARSLYQYVEEQKSILQKVPSKLISAVNGHLSNDGVEETPPPSSLSNGAASGSATNPKPDPDELFIELEHRNVAFRHWHPTPVTCNGNRLCGQSDLGGLWEWTSTPLAPHDGFKAMDLYPGYTADFFDGKHNVCLGGSWATVPRIALKKTFVNWYQRNYPYVWCTARLVRDIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9L1</accession>
    <name>A0A1C1C9L1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9L1"/>
    <dbReference type="STRING" id="86049.A0A1C1C9L1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06212"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07826"/>
    <dbReference type="eggNOG" id="KOG2425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="270" mass="30246" checksum="2FE27E3B1C5172A0" modified="2016-11-02" version="1">MVLQFPPWRHQSYLALVRDWFFPNHTKQDVFSATVSDLSQDLRQRAVDKVNLWMFKAGQLPPAMEATASLTEALLHDEARRWSSAPFISESAMQSIYAMAFARFVNAFVDRDVARSHIAGMAKEDSVVESEEEVTTVSGKGERSMYAHAATIGMPQKFVDIRHQVSHGDIPSVPLLKKMTEQALEWLWERWWVKHASGNPERALRELEERQRVSREARDWAIGTSAVPFEDGPSSGTSQDVLMEGGLDAASSVAAGATARKRKSTVIEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9T9</accession>
    <name>A0A1C1C9T9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_05968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9T9"/>
    <dbReference type="STRING" id="86049.A0A1C1C9T9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05968"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07907"/>
    <dbReference type="eggNOG" id="KOG4089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT45256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="337" mass="39181" checksum="B7EA6E0D3064E43C" modified="2016-11-02" version="1">MPRGIRVRAKINVRTTPPVLRTKRVHPVNGDGPRLWNAKRRIQSSKGLSFWQAKNLVSKDELRRQTWPGSKAWRPLIDNEEINMEWWKLDSETLPQFIEAHPNLRTLSQDVKTFIQQGSINLNRSNILRILLNPSKYFSFPYNVPLSMRKQVYFPSPKDAVVLMRTPHLGPRYAAFDVPLHFNKLDLKAYLKDVYNVDVLHIRSAVFQQKLDRKEGRDMYSRGQAFRPGSKKKMTCLLAKPFVYPEEPENLDAWEHNEYWASMKAIVEKNREESEWGMHNPSQKHRKAIAVQAQQLLKGKTRWAPTWQNFADDWRAMRGLTGADSTQQPAGGSRPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9W2</accession>
    <name>A0A1C1C9W2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type 2A phosphatase-associated protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9W2"/>
    <dbReference type="STRING" id="86049.A0A1C1C9W2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05990"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07910"/>
    <dbReference type="eggNOG" id="KOG2830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903432">
        <property type="term" value="P:regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39944" checksum="3B74BFE4FFAD8AE2" modified="2016-11-02" version="1">MAEDSEPSLGALFKQANNQQDELESLDPRTAQYKDTLQSIIHNLERCRQLIRQLSLFSTNEEVEDISTQDLQYLTVDCLLAEFKIKSYGADRLASLREAGELFENFLTLLDQYGLLAAPDRELYERFLEQKGSFRIVSTDSAEEKRKIKIARFQEEKSLKQKLQYLRNESQKANVDDETIRSLHLADIALRVNNTFSSLDMISQEMDILSQMRDSEPIIPSPVLPDQRAPGRSDNYSERLDGPTTMAGLGKRGGPLLSPSGKPLQPFTLTDKRTQLRQGVFRPGHSLPTMSIDEYLDEERRRGGIIDGGGNADAAQPEPDEDNMDAVDAATMKAREWDEFVEANPKGAGNTLNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA28</accession>
    <name>A0A1C1CA28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatidylglycerophosphatase GEP4, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GEP4</name>
        <name evidence="1" type="ORF">CLCR_06275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA28"/>
    <dbReference type="STRING" id="86049.A0A1C1CA28"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06275"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07967"/>
    <dbReference type="eggNOG" id="KOG2961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="198652at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010021">
        <property type="entry name" value="PGPP1/Gep4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01668">
        <property type="entry name" value="YqeG_hyp_ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="231" mass="25820" checksum="620A94FCB45F57BA" modified="2016-11-02" version="1">MPLFSNVPALRLTLAYALSEPSSLLPHRTLPTLLPLPLPVGPWLPSLNSTGKKPTIRALVLDKDNTLCPPETTKLHQAYINKIEKLKQSDEFSHNPHSILIVSNTAGSSSSAEHEAEAKLLEKELGIPVLRQHPERKKPFCGPDILTYFKNHGVTEDPKEIVILGDRLATDVLLAREMGSWSVWTRDGWRNPETPGRDYRGFFGRMESRFERFMRGGLGRTAPLPKTVPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAL3</accession>
    <name>A0A1C1CAL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_01450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01450"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03475"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2587356at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="607"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT45564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="639" mass="68483" checksum="ECD6CCA83A1EE2C7" modified="2016-11-02" version="1">MAGSLAEKRVGAEVEVTEHARSEARHVAVHDVPLDLDDPHKAALEDNPEKAESLTLTTFLAIASLSFSYVCPISCGFVLVTSILVPIGTDLGDTEHISWIVGGWSIASSVSFSLAGAISDVFGRRWTVVSGEIIAIIGSVSQAPPGRQAHTERCLQIIACTSQSTLMLAAASTVIGFGCGIIFVSYAGIQELVPNKWRGLLGLTECAMTLPWALAGTLIATSLNSNTGAKWRWCYYIGIIYGVLSMIGTILFYYPPPRPQYDFQKSRWQQIKEVDYIGFLLYTGGLTIFLIGLTWAGTPGHAWKSASVIAPIIVGILTLVACFIYDFTVPQQPFFPYSLFRQVREFTVLLVVVFVAGMVFYSFAGLLPQGSLYMYTSDPIQIGVIALPNGVAQVLCGGIATLFMGKIGHLKLQVIVCLIFQTVFTAAYAGFIPMNRAAWSAFQFFSMGPFALITLLCYVIAGLNVPLRHLGIASGLIGTFRSGGGSVGNAIFNTILNGVVKGQIPKKLAEVAATFELSADQLAALIPATAENAVGIPGVFASVPGITPAIEQAAAQAYKEAYAHAFRMVFYSSIPFGIIAIACACCIKDSSQYLTNHTAVHMVREGAMGKNPGRTKEHSNTAPVLEDSKITHSEDDRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAX3</accession>
    <name>A0A1C1CAX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01735"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03573"/>
    <dbReference type="OrthoDB" id="4147172at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650688" evidence="1">
        <location>
            <begin position="21"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="169" mass="18185" checksum="AC7EEF0C1A7DF2D2" modified="2016-11-02" version="1">MKLLSTFIVTVSLVVGLVAAIPQTSSGGSGSEDEIPCPAVYPCIDWYIILEYCSNTTDPAVATGESFTDTAPIKCACGTKALGDESGLYAAAECILCDDELPDADAAVAAQWFYTCYTFEESTATDALDCWNSGGTDCPAVPEKRKMSKRDLMKPNMLKRLNKPKVRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB60</accession>
    <name>A0A1C1CB60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_01632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB60"/>
    <dbReference type="STRING" id="86049.A0A1C1CB60"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01632"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03613"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT45716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="328" mass="35408" checksum="1B2E2D3994A625CC" modified="2016-11-02" version="1">MSQKDVWLISMLKKSVTGCSSGLGKALAKHAYEMGCPVVATARRPETLSYLPDGDKNVLKLGLDVTVADQVDQVIKTAVDRFGCLDVVVNNAAYGLTGDTEVIPDADARAQLETNFWGPVNVTKAVLPVMREVNPHGKGGLVMQISSVGGRVCFPGGAFYHASKFALEGFTDTVAKEMHPDWNIKFTIIEPGVLEGGLSPYQPLDADGKAVGAVLTNFVQNMTLPPRHPAYEDPACGYNKIGAYMASMANTVQWSDPTVCARVLHELASNRNETKPPLRLALGADAWAAVKAELESITRENEAWKSVAESTSHAENAKARDFLLDHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBE0</accession>
    <name>A0A1C1CBE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TRK2</name>
        <name evidence="12" type="ORF">CLCR_01418</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBE0"/>
    <dbReference type="STRING" id="86049.A0A1C1CBE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01418"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03680"/>
    <dbReference type="eggNOG" id="KOG1341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="138"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="327"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="807"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="815"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT45788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="886" mass="99976" checksum="49668C70A4FA699E" modified="2016-11-02" version="1">MENVLDKMGILGEWTVRFWEFSKKNVIPDVFIKRRFNFITIHYMYMIGMSLFGSVVIYGIGGMPYIDALFFASGACTQSGLNTIDINNVRFGQQFMMFLLAMLCNPIIVNTVVVFVRLYWFEKRFEDVVRNSNALRRTKSRQRTTTMSKDDPEQGIQGVAGRAIRILRNTGRSTGPPEGGEKREHGHGNGKAVDSSDTSSPDAEQPQNNLPSDHLRLKTSRSTDDVRLPSQLSPEQHIRFLENQRNPSDTTALRIPSPREFERGSRPQNIADGLDDTVLRPVTSEPDLPSANQRRIDEVNVADDAAGPTHIAFDEPHLLRDRHDRTATFPRLNTRQSTQPASSYDLPEPGQLRRRGSGTFNSLRRVNTPRTQDIAAPYLSWQPTVGRNSFFVGLTEEQREELGGIEYRALKALALILILYYVLFHLLGIICLIPWIWRSSTYGPIVTEQGSGRVWWGFFTSASAFNDLGFTLTNNSMISFQRAVFPLLLMTFLIVIGNTGFPCMLRLTIWATSKFCTKGSPLWEELRFLLDHPRRCFTLLFPREATWWLFAILVILNGLDLIFFIILDLNDPTVTALPVGIRVLNGIFQAAATRTAGFSVVNLADLHPAIQVSYLIMMYISVFPIAISMRRTNVYEEKSLGLYGSPADENEDENEPSYVGAHLRRQLSFDLWYIFLGMFIIAIVEGGRLQNTNQSAFTLFSVLFEIVSAYGTVGLSLGYPTINASFSAEFHVLSKLVIIAMQIRGRHRGLPYELDRAILLPSESLQAKEAKEAERVMSRVQRRRSSIGAHSNMSAVDGVLEGRQFRPETGLASGYRDKEEDPDLHLRPRANTNRSIQSHRTAGPNEAHQLHSNRHTEPHSARRGLGVGMFKLAEGVESIKEERSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBE6</accession>
    <name>A0A1C1CBE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBE6"/>
    <dbReference type="STRING" id="86049.A0A1C1CBE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01718"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03681"/>
    <dbReference type="eggNOG" id="ENOG502SIHG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2400485at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213:SF2">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="192" mass="21724" checksum="DAB2393628B58A12" modified="2016-11-02" version="1">MPEAPGSGTEDLHQKYEPHPDPEGLTGHQDKAVDYEPHPEKSLKISPEHEAIVKSISNLYCGSASERDMSVYAEKAIYDDPLSYCDTRHKIAGQWYGLPKIFAKLETKKIEVVKDTPTEIVFKQRQAYTPKVFNTTKEVDSLVSLSLDDEGKVRYHKDMWNDRDYSHSGIGKLIKNLNGDHTPKITQPPDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBF0</accession>
    <name>A0A1C1CBF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydropyrimidinase</fullName>
            <ecNumber evidence="4">3.5.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PYD2</name>
        <name evidence="7" type="ORF">CLCR_01481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16121"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="EC" id="3.5.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBF0"/>
    <dbReference type="STRING" id="86049.A0A1C1CBF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01481"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03689"/>
    <dbReference type="eggNOG" id="KOG2584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="6">
        <location>
            <begin position="54"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT45798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="572" mass="62250" checksum="BB6669E2D9A68042" modified="2016-11-02" version="1">MDLDLIIKNATIVTATEVLPPGLSIGIHGGKIVAIALSLPCTPSTRVIDAEGAYVTPGGVDSHVHLHQDNAPTGDKWLSGSRSALCGGNTTILAFATQKRTDESLFPVVRDYHTRAAGQSFVDYGFHLIVSRPGPEILGGPAMTAKMGKEADVNDRKDENEGELKIMVEQEGITSVKLYMTYPAYRLGDREMLDVMMRCREVGMTVMVHAENADMIDMITTRLLSSSHTQPKYHAVARPQIAETEATYRAISLSTLTATPILIVHMSSPAALSHARKAQSKQMLPIHAETCPHYMFLKSERLGATSHPFEGEDHSHAHLDGKLGEEVDEWAGARHICAPPLRHDDKDLQSVWDAVTNGTITVISSDHAPSQYHNPLGKKKPVHEYESGKTTIPPSFANTPNGLPGIETRLPLLFSAATDASVTASAARTLTLPKFVALTSTNPARMYGLAGRKGSIAPGYDADLVVWYPHSPRADDASRDKPTITITNDMLHHSIDYTPFEGFPVTNWPRYVLLRGQVKWDRDLELAEGPGKGILGRPGDGLFLKRAKGEVLVGRTGGEPEGMRLGETKSWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBG8</accession>
    <name>A0A1C1CBG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000018">
        <property type="protein sequence ID" value="OCT45890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBG8"/>
    <dbReference type="STRING" id="86049.A0A1C1CBG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00057"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00045"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="361" mass="39624" checksum="6430A0F1D0F5DB64" modified="2016-11-02" version="1">MRAAKEQAEELDQAGAFLNSLLTPGAESSRPQATSKEAVSHRQIAGRVKAPKMEHVARFADPPAPPPQQPLPEKPDSSKASPVATPFTNLLKRGETAKPSKNESHSPTNPQNSQMLSLIEALSIAKKELDSQGARVKQLEDMLKQERSAREDAEERARRLEQHAASRPVSQVEESPAIQVQPTKPGSDEQESIHDSDGELDAKTKHLQQNLDQVLGEMQRLKSDVDKFQRRAETAETDAAHARKSLAEMIDKIRVENEKAESLPKQLQERPDNEGSEAEAGAEPNESTMKSAVKSRPQVNGHIRPPVLPEHLERAVATVLRDRSSNADAIAQSAPYVSMLGVVLIGVGLMAYLNSWQKSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBQ6</accession>
    <name>A0A1C1CBQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000018">
        <property type="protein sequence ID" value="OCT45901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBQ6"/>
    <dbReference type="STRING" id="86049.A0A1C1CBQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00060"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00054"/>
    <dbReference type="eggNOG" id="ENOG502QPS4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="3">
        <location>
            <begin position="225"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35409" checksum="76A3DAC146F49276" modified="2016-11-02" version="1">MPDGTLFIFSDTSSELFDVFASETIKKMPNMPGMHRTYPNTGGSVMLPLHRGNNYEPEVMICGGGMSQVVDSLCDASCGRLSPMSQQPRWEMTEMPEPRGMVEGVLLLDGTVLWINGCQRGAQGFGLATKPALEAMIYDPCSDRWTPSGQSNIARLYHSVALLLLDGTVLVAGSNPNEMPVTMSQVELYDQDKAFPTEFRIEIWTPPYLRGDNASRRPKDIRLSRLELEIKSRFTIGFDMEEGLSTLDVILYAGGFVTHSVHMGQVMVYLVHRGWETLPNGRKRVEVYMPEGLNLAPGPYVVYVVANGVPGIGQFVTVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBS9</accession>
    <name>A0A1C1CBS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase, short-chain specific</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_00458</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBS9"/>
    <dbReference type="STRING" id="86049.A0A1C1CBS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00458"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10069"/>
    <dbReference type="eggNOG" id="KOG0139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF17">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G16630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="99"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="156"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="261"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT45936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="439" mass="48426" checksum="4F441180F9DEDA81" modified="2016-11-02" version="1">MAAISTAPYADPAWLSRDISPYYSDSHRRLQREAREYVSTCITPFCEDWERQGSVPRDVILNHARLGYTAVAIYPLAIKQIQETRQRLPGDILPEDWDGFHDLIVIDEIARCGYLGVIWALSCGNSIGAPPLINFGTDEQKSRFLPDVLSGKSRFCLGVTEPDAGSDVAGITTVAERRGDMYVVNGAKKWITNAIFADYCTAAVRTGGPGRGGVSALIIPLKVPGVKCTKLENSGVNASGSTYIEFDDVQVPVSNLLGEENRGFDIIMSNFNHERLWLACTSLRMARVCVEDAYHHALRRETFGKPLIANQVILAKFANFARDIEPAHAYMESIVYLIEHERIPKTRKGARQTDVNIGGMIATLKTSAGRVLERVNRDAQQIMGGAGYSRSGKGARIEQISRDVRVMVVGGGSDEILSELAVKLETKELHRLSRLESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBY7</accession>
    <name>A0A1C1CBY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBY7"/>
    <dbReference type="STRING" id="86049.A0A1C1CBY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00423"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10023"/>
    <dbReference type="OrthoDB" id="412402at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="549" mass="63870" checksum="71E1822C9CD7A9C0" modified="2016-11-02" version="1">MPGSISEQRRLPLTFGVEIEFLFGIRRDLVRYPEYWWLQVQNLRNNKPFKLNLEVTNQEFQDSDRSTGLLQARTIIENHGGELWVDSKTTPYADCFDKFSYWMIVPEEAVVDPKDPHELFQWSNGALIVHRESQIFDEWDWTGLELVSPALPVPDLDQNRPNGLVELTGYLNLMTADQSPTVPYVFMANPRNASVHVHIGLQPEPEGQLDFPPDFIRHLAWLCLAFEDTITLLHHPERHSYPESKSRSYANSNRKYLHAEGSSHRVHCCHLGKPFSAEDTFMKVFDYQNWHGDEDEDDIFPLLRALSSKKLTFREGPLDMADFNRFLFVNFENLAIAMVATDHSKKTIEFRQHHGTLSAREINEWVVFLTSLVRAGERFESLTPEREAAVPPTLMAKVMKKYKDPKQRDRALHEAKKYTQIWQQDRRSLKQLFDMLELPVHRRNYWWQRAKQVRAELHENWSGWEEGELDEPPWDGADDDAAYEEDDIINAANEVDMEDDESVPMDIDNDVPEPEDLIPRLDTLMTLSPVEEDADDVPMEIDDDIPSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCA7</accession>
    <name>A0A1C1CCA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LYR motif-containing protein Cup1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01232"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09374"/>
    <dbReference type="OrthoDB" id="5521299at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="390" mass="44038" checksum="A2ACB31DA73D18A5" modified="2016-11-02" version="1">MRKFTIDKFRSFIPRRSGKNKPGKKNNVGNNPVLAPEKVTQLLRLARKYAAVLRRANDGHATQLEKVLRMTYGRVGPNKYRLLAKFLYPSTDAAGGRSTLLLDRSSEEEDAAKVSKRPGGDDGLEELLEDDEGAEDAGSTPEKDTSYPSLYPTVSTTTTFTTFYQGAEVPDPPVEEKPPKWKLDVPPRLQALLVSQSIEQPHFTRAGSSPRVRLKFSPPTHTIWGKPLPFSRYKNQRIKWYNHNMQAALPPLESEAAYWEVHNLVTGRQEFPALIPRRTPARLSAEDDLRAFFQEQSSLILEGPAVDSRLKDLRRNRPHGITPRFLQRMLSRVVLSQTPLVKKAAPGTKTEADSGLVFYWDDGMSHQRHTREVENIHQPVPEKQAGLLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD01</accession>
    <name>A0A1C1CD01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD01"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01191"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09167"/>
    <dbReference type="eggNOG" id="KOG1196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF19">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="29"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="354" mass="38033" checksum="4F087522CAB3252B" modified="2016-11-02" version="1">MASAPSSTRTWIVANHPEDVPTFDSNDPGATFKLIDRPLPALGAGQVLVKSLFFSNDPAQRPAIDASIKEERHYTAPVKLGDPMMARGLAEVVESKADQLPKGTIVQASLGWTEYAVLDASECSPRQPLPNGLSLTHYLGAFGGPGLTAYYGLVTVGEAKKGQRIVVSGAAGATGSMVVQIAKNIVGASEVIGIAGSDDKCRWVESLGADKCFNYKSASFEQDLTKATDGFVDVYFDNVGGSILDLMLSRIKQNGVVVQCGLIAGYNGMKPTVLKNYFQVIAMRLSIRGFIVVDFADTFPETIKLFTQALKEGKLKISNEESEQVVDTKFEDVPRTWLKLFDGGNTGKLVTKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDF1</accession>
    <name>A0A1C1CDF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01981"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01215"/>
    <dbReference type="eggNOG" id="ENOG502S7FM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5327145at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="422" mass="46926" checksum="EA88F9F836FA8AE1" modified="2016-11-02" version="1">MANILAARDQENLIHAHQTTAAGKHLNQNIRTLHPKTPANLKTPFRAAKNDENLPITLKAQKDVGKDGASKQDKGSFVTPVAPRNRAPLGAKTTNARAFQTPAPLTVKPGRTQQKVSTSGRRSNRSKIAVARSEPVDTDVLLEQPLEEEEPDFGYAPPAPVELPDPPIEFAEHHELTEELRRGYGLAYPVDSPKDENGFSIRQRKEEEEWKKQDEERMKKSLEELGKPIFPTVAELNKQVNDMIAAGPKKRAPLSRVDSTEARCAVAALSEPQPRLPSAATRSTQASEQKKRDLLLGTKPASLAARNPPTSTRPNHSALSRNTIGFPKAKKAPSIMPRSVAISAPKPVRIDQGSIHPRDFRDLYGSPPVESDMWFRLKKYELLEEDLAKDNADIEEELFESDFFPFDNAKLDDEDFQLPMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDF3</accession>
    <name>A0A1C1CDF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_01802</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDF3"/>
    <dbReference type="STRING" id="86049.A0A1C1CDF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01802"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01230"/>
    <dbReference type="eggNOG" id="KOG1005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049139">
        <property type="entry name" value="TERT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21399">
        <property type="entry name" value="TERT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13 16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="605"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT46501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1120" mass="126353" checksum="B79851A579A4AA25" modified="2016-11-02" version="1">MARKRKCSETTSNRAVKRAKSANRDQNGVRERSPYLHHSVLSSFYPQVCTLRNYLLAGLPTSSRVRRRKLTGFEKDEATSILDTCLVGLLTQPSISVRESRRIEFATFTQTQARATGANTGRGQPCCIDEVIDFVIWSLFRGHLSKRGRPSHILCHGLQRGAVHEDRPGAVPTSLPGIIRRHPNDNLTALKTPPWSDILPLLGADAEVIFSSLLLDCGIFTRIESGKDNYFQLSGIPLSDLPELKPARAERAPPSNARKEHVLSVNSISFARHRMLYARPSLNAAGKVKFGLHHTHVLQRLADDTDQRQAVHLLKYIFPRQFGLHNVFRSKARADETTQKYSDYTFREQEITSQRKRSPSWTPRRLRGETIQFVRKIHRNHKACSYSQLLRHYCPLNSSQCQGHAARPGGADLSLPSSDPLVTQHLLSGISNGRVDTPVKGHDGDTSFLPHATPAARVSAFCRAVVSSLLPRNAFGSGQDGQENRRMILNKVDDFVQMRRFESMTLHQVLQGFRITSMTWLFNPGNPKGKMSKSDYSKRCELLQELMYYVFDSLLIPIIRAHFYVTESSTHRNRLLYFRQDVWRKLSEPSLATLRLKMYSLMTPSNARHQLQSRSLGYSQLRLLPKDQGARPITNLKRKQSKAGPGKRVVGQSINSQLAPIFSILNFERTRGPGRLGSALLSVGDIHGRVAEFKRTVPPGSRLFFAKVDVESCFDTIPQDHLLRLVEDLLSEPLYRTTKHIEVKSLEPGYQGHAEGLKRKWAGIARPAHEQAVFSDTTISGLAAKKRQVIFCGLGQQRVWSRQSVLKLLQDHISDSMVKMGKRYAKQVDGIPQGSVLSSLLCNYFYGAFERNELGFLHPQSCLLLRLIDDFLLVTTNDKLARRFLEVMASGDRRYGIQVNPEKSLVNFDVTIMGRKVPRVPGEAAFPYCGMAINVRTLEMKKDREKKDERVSNSLTVESCSRPGVVLKRKIMASLKNQMHAMLLDLSLNSRAQVISTLVGNFNEAAMKMHQYLVGMAARNRPPPELVRGLVQDLVVAGCKICRAKNSGHGQVQHITQAQMCWIAAVAFEGVLTRKQTQYQDLLAWLKALRAYAQPRMNMEQAVLERLLQDNNKAFQAYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDM6</accession>
    <name>A0A1C1CDM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aflatoxin B1 aldehyde reductase member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Akr7a2</name>
        <name evidence="4" type="ORF">CLCR_01975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDM6"/>
    <dbReference type="STRING" id="86049.A0A1C1CDM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01975"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01357"/>
    <dbReference type="eggNOG" id="ENOG502QU2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="338" mass="38092" checksum="A8BDA4FEED74CCA4" modified="2016-11-02" version="1">MPLVTSSMGTQKPRVILGLMTFGPPGTESKGGRITTLDEYNKNLDFFQSRGYNEVDTARAYIGGDQEAFTREAKWKDRGLTLATKCYPVNPGDHAPEKLRASLEKSLKELGTETVDIFYLHAPDRSVPFKDTLEECDKMFKEGKFVQLGLSNFAAWEVAEVWNIANERGWVKPTIYQAMYNAITRDIEKELVPACRKYGIDLVVYNPLAGGVFSGKYKSKSEVPSEGRFADLHRAGKMYRDRYFHDNTFLALQHIEPVVQKNGLTLLETALRWCVHHSMLKFAKDGGNDGVIIGVSSLQQLEGNLADLEKGPLPDEVVKVLDEAWEVYLKGRGPTYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDZ9</accession>
    <name>A0A1C1CDZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Maltose permease MAL31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MAL31</name>
        <name evidence="10" type="ORF">CLCR_01871</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01871"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01412"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="60"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT46691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="557" mass="61917" checksum="4F6B8FDA327A9627" modified="2016-11-02" version="1">MATDKHADAIHLEAHGGVERLKDVDLRDAALAGGALEGAAQEHSMGVLQALKTYKRAAFWSVVISTTVIMEGYDVTLLGSFFGYPSFRLKYGAYLNEESGYQISANWQQKFNCLGALANIIGALLNGWATARWGHRRVLMGTLFLLTGFIFIVFFAPTIEIMLVGQFLCNIPWGVFATTGPSYAAEVTPLAIRGYLTAYVNLCWCIGQFISAGVLKGLVNNPTKWSYKIPFAIQWVWPVPLFVAAYFAPESPWFFVRTDRLEDARKSLERLTEPEHHHDENGSIDATLAMMVHTNKLEIQERAGVQLWDAFRGTNRRRTEIACMGFLSQITNGGALCYSGSFFFQQTGISANAAYGIALGGTGIAFVGTIISWLYIYRLGRRTIWLWGFASLVVLLWLIGFLALPHQTLGLAWAQSILCIVWLGAYSMSVGPIIYVLVSEVGSTRLRTQTVVLARSTYYVGNIICGGLLQPQLISPGAWNAKGKTAFFWAGLATLTFIWGYFRLFETKGRTFGELDFMEFVHAQFQHGVPARKSAKYHIAEEELYNADDVVKETVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE21</accession>
    <name>A0A1C1CE21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_11254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE21"/>
    <dbReference type="STRING" id="86049.A0A1C1CE21"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11254"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="112" mass="12548" checksum="8174EA283C7FC4AF" modified="2016-11-02" version="1">MTRGHKKELDGPFLLAFGTGSTWRKEEPGSLNINLIEIVKEALQSGYCHLDTAEPFTTSNIRAAFDQTLQNLGVEYVDLYLLHDPYSAKTEEQPHTAWVELEGILDSGKLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CED1</accession>
    <name>A0A1C1CED1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">tfs1</name>
        <name evidence="13" type="ORF">CLCR_02570</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TFS-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CED1"/>
    <dbReference type="STRING" id="86049.A0A1C1CED1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02570"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02524"/>
    <dbReference type="eggNOG" id="KOG1105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000001">
        <property type="entry name" value="Probable Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.30:FF:000003">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="12">
        <location>
            <begin position="141"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="262"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="88"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT46884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="304" mass="33475" checksum="4EC0FAFB45A84A8F" modified="2016-11-02" version="1">MDRREILSKGASLQKAINAKEPSENILTILRDLKTNVKPSEELLRATGIGKIVNKVKGVQGLDPEVSKLAAEIISRWRHVVNEQKLASGTSTPIANGARSNGTSSPAPPAKSASPTGVAPDKRNWKVDKVPRDDLVPHDKARNNCIGLIYDGLCLGSDLPMKTILDLAKQIEAAALNLPEANGSSASPVYKEKIRSLFQNLKNKSNPKLRIRILTGEISAQRFVTMSHEEMKSRQQKEMDNKIAKENMNNAMVAQEEKSVSTSLECGKCHQKKVSYSQAQTRSADEPMTTFCECLHCGNRWKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEG1</accession>
    <name>A0A1C1CEG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02094"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01561"/>
    <dbReference type="eggNOG" id="ENOG502RPVC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="202" mass="22829" checksum="020E9FFDBE3C9978" modified="2016-11-02" version="1">MNEDLARIQIKRPQNPRVEQYLQQPKQGFLLTTQSWISSRDILESSIAFMLENDTSRHLLFAYAYAMRRAHRAADGNPQDQVDAERNLGRGTNILWNRLQMAGHASSDANLQAVLLLVAYSADFGQENEVRLHTDALRTMVDQRGGTDAFTNNPSLQHQLLVIGSSRRFHLTLDCESGCPDLLRFPDGLRLPQGANHSRMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEH6</accession>
    <name>A0A1C1CEH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPN10</name>
        <name evidence="5" type="ORF">CLCR_02551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEH6"/>
    <dbReference type="STRING" id="86049.A0A1C1CEH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02551"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02526"/>
    <dbReference type="eggNOG" id="KOG2884">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="302" mass="32389" checksum="87A5435A9559990C" modified="2016-11-02" version="1">MVLEATMIVVDNSETSRNGDYLPNRFSAQSEAVSLIFNAKTSSNPESAVGLMSMAGTGPKVLNTPTTNFGAILAGLHETKIKGHIRLGTAISVAMLALHHRANKSQRQRIVVLICSELDQKFGDKNDTEKELIKLAKKCKKNNVSVDFVAFGDAIESSTKSILEKFVEAVGGSSGEGNYLAVIPPGPGLLSDSLITTPIVNMGGDAGAGGSGMEGVETGGGAGRFDEFGIDPAADPELAMALRMSMEEEQNRLERERRAREEEERRNADRMETITEEGQATSGENKEGSDSKQPRVEDDKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEQ6</accession>
    <name>A0A1C1CEQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MmgE/PrpD family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02416"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02416"/>
    <dbReference type="eggNOG" id="ENOG502T3UV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4120269at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="3">
        <location>
            <begin position="285"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="49584" checksum="F0BAB3691126D804" modified="2016-11-02" version="1">MASNGDLKHPPSLTRLATRRLRQIATEELQPELYDKAVYCIIDWLGAVHSGLSLPWKDALIKYAQLNRGTPEAFAWGVNQDISTETSAFVNATLAHSAIRDDMHLAACSHIGSIVISAALALAQRHQWSGETLLRAIIAGYEMAALLGTAIRSRGTFNAHFRPSGLIGAFGAAAAAIAAENVEETVAVNALGYAVNMCAGFNEWAWSGGMEIFVQMGVASRAGIAAFDLATAGFECSDTALEGKDGFFNALSVGPAGAEVFKDWLNTSPIGQGILDVRFKPVAGCNYAQTTSAVAVRIYQKHKPSDIKEINITATSQAVKYPGCNNAGPLTTIQQTKMSIQFGVSAALVFGGLGEEIFKKADEPRVNQLMSKCRLQSSAEFDKLYARGLQPATVEVTLVDGTVLRESAEDVPWLSESDVEARSVSEQAQDIPEDAAVKVVALCKKLRSLERCGELLETWKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEZ2</accession>
    <name>A0A1C1CEZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02420"/>
    <dbReference type="OrthoDB" id="4148626at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="485" mass="53478" checksum="D70F4EBA66D003A0" modified="2016-11-02" version="1">MTLIDHTGLPRWVYIVIIAVGSILLLAILAVGLRCWVLRRKARQRHEFDGLTGGPMRRVTLRRGRVVPSSQHLSLTGSKFGMRQFGILADNDSMMTGRRSPFEWWGTIMERSQSRQDQMSQVETGSIMTRPASRATTITGRKEVDGTPTQTPEKDTETVTRTWELTLPSPSPSPSPLGPNRTTNFSRSFSNRGTSSPITQRSQATLSRISERSPHDSIISAANGPNVSSQHRSSYHSAINPLDNTPLQERMPQPSPTTPRKSANLAIPSPRNRPPTQLPSPSHDSSTPSHLRSTSGRQSRRYDALPDQASGPSLPKAVAHPITPTAFRLNLPEFSSPISNSFYRQPNPSRLDVSHSRADSNVTSLSASTTHSPRKSSSSVGPSGVFYETQVPRTRNGADYWSARVDSDDVPPAAQRESSSGVPRSGHSRNPSTDQHRQSRYSRDEQRGEVQENRIGIMTVPGKHNTRVLRKKSLRRGQVVSSLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFE5</accession>
    <name>A0A1C1CFE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02602"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="193" mass="21045" checksum="6BEA8B4C41EC7D8B" modified="2016-11-02" version="1">MELDLANSTASHPPKLVHHHIQRGETSLQALKPCDGTKFEVETNIDTDTDTDTDTDTDTDTDTDTDTDTDTNTNTNTNTNTNIEVDLDIDSHLALALALDILITHDTTRQDTTRHDMTRHGPAKERKERKGKERKNRRGTPANQVIQPVIQPVIQPAIQPAIQPGSPDSLVPARAAPRCAASNPLGVFGVFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFR7</accession>
    <name>A0A1C1CFR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 91 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_02305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFR7"/>
    <dbReference type="STRING" id="86049.A0A1C1CFR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02305"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02137"/>
    <dbReference type="eggNOG" id="ENOG502QTZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3631276at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021988">
        <property type="entry name" value="BMT1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12141">
        <property type="entry name" value="BMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="614"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="651"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="685"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT47297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="712" mass="81095" checksum="96B34FE84938080B" modified="2016-11-02" version="1">MGVLPMIDRFPAPARIQRLSVFALGTILIVLLLENTLFPEASVTSLHRRGDRSRSQHYQQWGAFEPMLIPGYVNTGLPGKRSCDTLKYNSTVGVQQSFHLNDDIHQIAVALDQHPVVDYPDEMMNDPEMDMRDIVEKTWTRLAGSSVWLPEQKVYLSVTRVVFSPSRTRTVPKMSFLRGQLFNEDWDHLTNHTITWSGKQFAFPMVFDIPAQWEDHGGMFGPEDPRVILEEGVEDAEPVIIFNMVSRKSDWKRAMHLFRPFSKASTMLTIKDTERAYNENSWAPFFIPEQEQQTLLGKIPLPVPGVVRKPNEYIHFVYSFRPLHVLKCHMRCGDCEFVYEQDVPDKVFNKHHDEAGSVRGGTNFVPVPIPSSMDIDSRVRVYAAFPQTNIAKFCDGNFYRPEFAVMINIGNQFQLAFASESLDFGDSILELGPDDDRCEKSRILTPNTVVRWDTGSGQDVMTVTFSVNDETTQVSRIRGLLGFVRNLPQFKTLLKRDGLLKGADADLVSILASWVGDDIRGCLIESAANYTGITMEDSDPRDEDQEMDLSKELMLRLKQIKAEEAERNRAKEAGSESSPGNEPALPILEHPPEEEEEAIFHPELLGEFEDVEGLAVEGLEDEGAEDEGKEDNPKEDELPKGEKEQEDDTIEQEKNDVDAKDEALKPEGLDRLVGEDKEQQERKPLHPPKAVHNHDSHHHRYHKQHNWRRAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG45</accession>
    <name>A0A1C1CG45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG45"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03758"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01950"/>
    <dbReference type="eggNOG" id="ENOG502RP2Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4151650at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="109" mass="12506" checksum="E7C6607D05AADC0E" modified="2016-11-02" version="1">MRLPNGFIAKAPPMPSLAVRRCFTSSSRAFQPTAIHRAQRAADIKAHPESSLTQEKLPDKDHNRHWTEENATPSEADTPFLFCYDQFCNYPEKQLLMGRDARFTPTMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH83</accession>
    <name>A0A1C1CH83_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoplasmic reticulum-based factor for assembly of V-ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_03657</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH83"/>
    <dbReference type="STRING" id="86049.A0A1C1CH83"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03657"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04481"/>
    <dbReference type="eggNOG" id="ENOG502RXKD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19981at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT47873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29511" checksum="EAEED46D87FEC0C0" modified="2016-11-02" version="1">MVLLQATPRILSAISSLSSADISALTNDETTLPTSCEQPIEHKTLIALSRRLSKPQGHRSSTLDILLRGTHVYIPPPPPKPQPSAEYIALMDRLRKEQEQREYAGLVSKREAAGLTSDNEKDDISPSLVLNILLSIVLCAMAVFHLTRWWSNDGVRVLLSLATGIVVGVAEVVVYMAYLRKVAVSKQKERSRTERKTVIGEYRGEQILTDAHGRAVSIDAATMMEKEEIWGRGINGGMRRRVREKWEKEQKNARRNSLSSSGISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI11</accession>
    <name>A0A1C1CI11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04402"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08309"/>
    <dbReference type="OrthoDB" id="4152251at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="159" mass="17898" checksum="FA30BD3A7D3200FD" modified="2016-11-02" version="1">MEKKQLEGVVFGSGDPIDPLDRQLLTEILNPVLDAGPRKSSLMTSGYLAAKAKLAKAQTSANVLEAHSQVEVLNIEPQDIQHHSINEHQTPQWSRRSSPGPQHQVNASVPDANYDGMETLVMTSSLHVDSKHDEMQHFCDDYNPMIKWRRRTLIFETMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI12</accession>
    <name>A0A1C1CI12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetrahydroxynaphthalene reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_04295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI12"/>
    <dbReference type="STRING" id="86049.A0A1C1CI12"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04295"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08244"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT48092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="269" mass="28561" checksum="509C9F069711A4EC" modified="2016-11-02" version="1">MTFTIGDPVPTSRLDGKVALVTGSGRGIGRGIAVELGKRGAKVVINYSRSVKPANEAVAEITASGTEAIAIKANIANPDEITQLFEHAKSHFGKIDIVVSNSGMEHFGSIDQITPEAFDQVFGLNTRGQFFVAQHAYKFLSEGGRLMMMSSISAHVGMKEHALYSGSKVAVEAFGRCLTKEFGHKKITVNVIAPGGVDTDMAAEAGWKYIPGADPSWTADDISKWVAERNPLQRTGKPQDIARVVAFLASEDGGWINGQTITISGGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIE0</accession>
    <name>A0A1C1CIE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DNA replication licensing factor mcm4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">mcm4</name>
        <name evidence="18" type="ORF">CLCR_03831</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIE0"/>
    <dbReference type="STRING" id="86049.A0A1C1CIE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03831"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08426"/>
    <dbReference type="eggNOG" id="KOG0478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000011">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="585"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="317"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT48280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1006" mass="109747" checksum="8B7211E07E3E9D0F" modified="2016-11-02" version="1">MSSTPSSRLRGHSSRNSQSSTPARPSDATPRSTRSAANAAAAAASSSPLFFQSSSARGTPAPGSQLAGDGMIISSPPRQLSNAGDRETTPRASTRPVADSSPVRYDPSSSPVRSRHEPQSDIPTSSSGLFVRQDGAARISSRRGDIHSDAFAPTPAHRRRIYVGEDGMPVREGHDPASEATFSNLNPDTSEADAMGGDSTRVIWGTNISVVDSMASFKNFLYNYAKKYRMWADGATEDETRALGATADEKEYLEMLQTMRRMGVHGLNLDARNLKAYPATLKLWHQLQAYPQEIIPLMDQAVKDVMVELAQKEMQDLRRAHAAGPSARVRDGSSMPPPPSSDLNAPTPVATGTAPEDFPDLVEEAMIQPWKVMPFGLDKTINMRDLDPADIDKLISVKGLVIRTTPVIPDMKEAYFKCTVCNHSLYVAIDRGKIAEPTICPRQACQSKDSMEIVHNRCVFADKQVIKLQETPDSVPDGQTPHSVSLCVYDDLVDICKAGDRIEATGIFRGNPVRVNPRQRTVRALFKTYVDVLHVQKVDKRKLGIDASTIEQELSEQVAGDVEQTRKVTAEEEAKIKATAAREDIYDLLSRSLAPSIYELDDVKKGILLQLFGGTNKSFAKGGSPRYRGDVNVLLCGDPSTSKSQLLQYVHKIAPRGVYTSGKGSSAVGLTAYVTRDPESRQLVLESGALVLSDGGVCCIDEFDKMNESTRSVLHEVMEQQTVSIAKAGIITTLNARTSILASANPIGSKYNPNLPVPQNIDLPPTLLSRFDLVYLVLDRIDEVNDRRLAKHLVGMYLEDTPENASREEILPVEFLTAYISYARNNIHPSITPPAARALSDAYVAMRSLGSNIQAAEKRITATTRQLESMIRLSEAHAKMRLSHVVEESDVTEAVRLIKSAIKASATDARTGLIDMGLLSEGGSASERRRREDLKRAVIQALDHDPSVRSGNPIRYTDLYRAVGEGSSVEIEGAEFNEAVKSLELESRVLVSGEGGRRSVRRVTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CII5</accession>
    <name>A0A1C1CII5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="20">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">cbr1</name>
        <name evidence="23" type="ORF">CLCR_04226</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 20">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19 20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="20"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CII5"/>
    <dbReference type="STRING" id="86049.A0A1C1CII5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04226"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08473"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19 20" id="KW-0274">FAD</keyword>
    <keyword evidence="5 19 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12 20" id="KW-0520">NAD</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="22">
        <location>
            <begin position="63"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OCT48329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="308" mass="33633" checksum="A42647405897B3B3" modified="2016-11-02" version="1">MGNPAFSQANINGVYIPSVLLIVGVAIIKREYVPYAVAFAALVGGYKIFASGPPSPRKVLKPDIFQEFPLTDIKKTSHNVAIYRFGLPRPTDIIGLPIGQHMSLAATPKGADKEVVRSYTPITSDEDKGFFELLIKSYPQGNISAHMTTLKIGDTMKVRGPKGAMVYTPNMCKRIGMIAGGTGITPMLQIIRAINRGRPQDTTKVDLIFANVNPDDILLKEQLDALDKEDPNFSVYYVLNNPPEGWKGGVGFVTADMIKERLPPPAPDMKILICGPPPMVSALKKATESLGYQKARPVSKLEDQVFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJU9</accession>
    <name>A0A1C1CJU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJU9"/>
    <dbReference type="STRING" id="86049.A0A1C1CJU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05302"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03109"/>
    <dbReference type="eggNOG" id="KOG3368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="84" mass="9274" checksum="4F7B69ABF36A85E8" modified="2016-11-02" version="1">MFRPILIGAAECIYKRRWLPLSVSTTGKTSRPPSQAYVNGGSQPRAALSADDDAKLIFGTVFSLRNMVRKLGGEDDRLLSQSWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKN4</accession>
    <name>A0A1C1CKN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04885"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02848"/>
    <dbReference type="OrthoDB" id="4117455at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="423" mass="46242" checksum="3BC48DB300C4BCDA" modified="2016-11-02" version="1">MDGFDDAAPEAREQREDRGPRIPPAKLSTINATPAISIFYKPDKRSPVTLLDSKFPRDAAMIFCDRIRHDIMDNGSKSFTIVGGDLNGHKLVLAWIRQCVEEQSIVKFKDGTFQILSIADSPSNRQLDESTPGFFTTYANVILSSYYLGIPARDLSDHLLKRMTAIARKQLMTWDEVDWFYETAFPSTVPQEKEAALRGVAAASIFWGWWAAKLDSEETPGEMRVLDVMRQENKKLDDDLHAWCERNEKDVRRKWDEKSKAKKYGAQTSNGDGDGAGWDQPAATTEGNSGGWDNAVAENGASGGWDVAAPIATAGWDNSAAATSSKGIGANSWDSADALNDNDAPFAPPNSLASPGFSSAKNTHTPLPPLSEITNATHFGENDGFSGTTGEGGDWADEVNAEVVDQGQHYHSNQGHQLGNNQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL27</accession>
    <name>A0A1C1CL27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL27"/>
    <dbReference type="STRING" id="86049.A0A1C1CL27"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05219"/>
    <dbReference type="OrthoDB" id="4153956at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="160" mass="17915" checksum="DDBB6DE2AD5B08D9" modified="2016-11-02" version="1">MDHKRKSAIQFNIAPCVDAETKRLRPHIANAKFVLINRLWVIAKLSDTINDRTRSLNAISIPARLYATYTALGQSYDAELRNLRQVDGQMHAYLSFLELAPVLCVLAVLDIGRLECAAQPGSFLLANVRIAVCSPRQYPEGSKLTNRSLVNYSILMSWAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMR8</accession>
    <name>A0A1C1CMR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NIMA-interacting protein TinC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMR8"/>
    <dbReference type="STRING" id="86049.A0A1C1CMR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06651"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08706"/>
    <dbReference type="eggNOG" id="ENOG502QRXF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF11">
        <property type="entry name" value="TINC (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="883" mass="98188" checksum="F019802747EC5B95" modified="2016-11-02" version="1">MLIVTSNPKDYADNQDARQYDRRLRGPVDERRELSINPNTGLKNYIASEGMGIDTSAGLVRKLLGRSIELGRQYARNKNKKDLYEALRLLGTASHCLEDYAAHSNYVELALIELGERDVFPHVGRRTAIQLREVRHPVFPIVTGTFGGVDFLHSVCGEFDDKATQSEIEELDNTLQQYQNGNQDNSILQDLLDKVPSGVFGGKDESGKANELKQNALNHQMQNTNISPRRPEEWTRYINDVQKQIYPIIEWHDEIMQSITETIEKIPILPDLIENIQEEVNKFVFSLLAPYVVPIINQVKNELNTGSNEIIQSSVAQQHIVFNDDHSSDPTHSMLSKDHFSNVLNEPAGKVARQTVKWVVPQIVACWDDESVDVERTLNRVIHGVLHHPALRDYGQDGASDGRRLMFGVVEEWWHGKSEREKDGLREQLSRRGVETGRNHKPGVKDHGHGSNRPLGMAKLNYNTNQSSIGGGIAGDALGAIGSALGGNSQSNQRPPNVQRISDQAGRMAGEALGGGVLGSLVGGIASQVSGDILGGGLNQGQETFKRESYNRQDQSRTETVTQVGHSQGGDRYGQAQYSRTYGDSGERRHEEYNRFEQRETSSGGWQSEVHRQERSGEGRYHEETRYASPPPGPANLTEVFRRYGDDDDESSQRRRQEHHQGRRRDDDDDDNNRRRHNRDEESHSSGGYGGSGRRQQTESSRYGGASEGYGHQEGREQYGRREDDDNNRFSGGDRRRNDNDNAYSSGYGRQQEGGFGSGGYGSRREEPQSGFGFSGGRREETSYGSGGHGGGSGYGRREETSYGSRQEEAYSVPGAFGSSQQDEYSAGGGRDEYGRSQQRYGGGDAYGSRGEENEGYGGGRRRHGEGEGEGEGYGSRYGSSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMY9</accession>
    <name>A0A1C1CMY9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_07481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMY9"/>
    <dbReference type="STRING" id="86049.A0A1C1CMY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07481"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08771"/>
    <dbReference type="eggNOG" id="KOG1729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15760">
        <property type="entry name" value="FYVE_scVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="141"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT49849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="263" mass="29434" checksum="D5514341949F3A41" modified="2016-11-02" version="1">MNYPAQPFTIPDYMSQQPSPASSTSPASPRMQDYIQQHAPNPYKQLRPLKSPLYVPAALRPTEHFCNPSPMTPPKSLHGSLDSLQEAEARTASPDAHHDLGLDAFDHDWAQEEELGEVTGPPTRDHWKPDQASPTCDSPQCRSSFSLFVRKHHCRHCGHIFCSSHAPFTIPLDQYAKFHPDGSPSRACEVCHRQYQRWDTARSIRRKDSQNSREDGSNHESGPPTPLAGPGGHRRMISSGIRSGRPVEQVANSVPKDWAWSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN44</accession>
    <name>A0A1C1CN44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN44"/>
    <dbReference type="STRING" id="86049.A0A1C1CN44"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06976"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08849"/>
    <dbReference type="eggNOG" id="ENOG502RPVT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3251668at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="567" mass="63952" checksum="84D6235FC4333D4C" modified="2016-11-02" version="1">MSDRRTEVRRTRGGCVTCKRRWVFQYSKRPSPGLSMHWLNVFYPVRKKKCDLTRPSCQACQRLGLHCEGYLPRLLWEDDPVREGIRRRGPPKSKKQAPPGAIADNRDMTAVVMGGIQGTTTTSRSQVKHVPSTLSATASLSHIVHAEGSGTPLESLLWDHYINCFARKYPTCSNSENPFLSCLIPVAVRYEPVRFALLALSGLNAASRNFPSLQLSTKVFRLRALEGCQNMYSGSRSRDKPKSAEDFFILCSPQVLLTLDEADKLCLVTTALMLALFGKLSGQDYDSFRPYLEFAQYYFTCKTTADSTLAGVFTTPLPLFLHSLVTYNHLLAMIAITQPPLMVDRRLQVPSFLPLSRCPPQDFVSLLWCIGNDVENVGLADFDLWNGDFNFLPSFSTRSVRPPDAQGHVRGRIFQSATGTMHANVQDEQATVQEIYRTSSRIYFFRQLRDRVDLIHSNTTRAYPPFVAQAQIRKFTKFAMGILRALPRDSVFNSALLFPLGIIGPELTCENDQAFVLQKLKLLQETLYFEVFRLFAEDLAKSWAQSHSCDHAARADGRHKTAIRLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNB8</accession>
    <name>A0A1C1CNB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07235"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08856"/>
    <dbReference type="eggNOG" id="ENOG502T4ZU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4224127at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="414" mass="46762" checksum="EC6D852C59E1BD73" modified="2016-11-02" version="1">MSTIRFFDLTPHIVRYGMQNECEGKCWILFWRNAVCFRVSVSREDVSDTPFATKWLELNKEGAPRVEGMKKWVERWNELCDCIIGQCMPVLQELAPPTRQWKTLEDHLRTLAYELKMVEDQETGDAVAKITSGPVEKPSYEHHLLPFSDFESMPEDLPRYRAQDLRVLRQEKDWRHPPAKVQTQDGKVLYFLSCNKPTRNARNGEISNASLNTINAYSLLHSKLKDGVGGHIPKLQGVVVSDAGGGLQHWGAQGHLPATNQSADEETGKELLVAGVLLTYVSKAKRWAVAEGMFADQKDSAEVLKCKEKWNRQIASAVQVLHENGIAIGGRLDSDNPWSYINQHTVHIAPIESGEDTNDVAGLRSTLLAADAWLMLHAKCTTLPPADQQQEQDKQNFEEHKVVDWKAVDKLFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNG0</accession>
    <name>A0A1C1CNG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative NADPH-dependent methylglyoxal reductase GRP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GRP2</name>
        <name evidence="4" type="ORF">CLCR_07528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNG0"/>
    <dbReference type="STRING" id="86049.A0A1C1CNG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07528"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08960"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="261" mass="28579" checksum="CD4CFD5199B44C44" modified="2016-11-02" version="1">MRRVLLSGGSGFIAAHVLDYLIQRGYSVVTTVRSTSKAEKIRAAYLKIGKDRLDFAIVDDIAQDNAFDDAVVSNPPFEAAVIQTASPFHFNVTDVQRDLLDPAIKGTTGILKSIIKKAPTVEQVVVTSSFASVVNLFQGSWPGRTYTEQDWNPVTLEQASENVANGYRASKTFAEKAAWEFLQQENPSFSLTTLCPPQVLGPVISHLSSLDNLNTSNQVIRDLIQGKFKDKIPPNATFTWVDVRDLALCHLLALEKAGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNY9</accession>
    <name>A0A1C1CNY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_07507</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNY9"/>
    <dbReference type="STRING" id="86049.A0A1C1CNY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07507"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05766"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="37"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT50217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="271" mass="30042" checksum="DC9F77CB89E9191F" modified="2016-11-02" version="1">MAQEQAIYSHGHHKSVVQDHARRTAQDSAAFLLPHIQPNHNILDVGCGPGTITADLAALVPQGNIIGGDAVESVLEQAKEFASSRGLTNITFQKIDGNALPFPDNSFDIVFAHQVLQHVKDPVRILTEMRRVAKPGGIVAARDADYKSFAWYPETPEVPRWAELYQKVAKTNGGEPNAGRYVHVWARQAGFAPGEITATWATWRYTGERMTQFAQSWSGRILQPGFMGTAVREGFATEDEIKLISEAWKIWPTHEDAFFGIPHGEILCRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP15</accession>
    <name>A0A1C1CP15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal specific transcription factor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_06781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP15"/>
    <dbReference type="STRING" id="86049.A0A1C1CP15"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06781"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04136"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT50240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="691" mass="76808" checksum="C1F886B954655518" modified="2016-11-02" version="1">MPTKRITESERRRCVKACDPCKRRKERCSGARPCNRCVVRSTEDQCQFTEARPPSKASERLTLARRDDASAVLAIDFLTARRDDDQSALPSLSPATFSIGTGAESPRLTRDHRGGYVFIGDSASMSLLQDVRRLVSMFVSDCAFVNDHNQNVMLESLPLGRLTPHPLGLLVEPARPSLEAARVLVSRYCWTTSCFLDLFDESDLLERLPSWISAPNASSDPSNMIFHLILAIGLQSCNDDNDDLAESHFKYAKCALLSNLLEDPSITVVQAHALIVLYLIAAAQRNAACMYLGLAVQGAHALGLHRGDAAAFFSPHEFRVRERLWKTLRTLDGHLSYSLGRPILTVELRDPEPKTGYSSLAGLTNIFSTIMQEVYDKRRISADTLGKVTRLHRNWTRRLSEGLTNDGIPESTEIMVSGVMRPNIGLFHVKSAYYLTIILMTRHCLLDQAQARVQRAGSQRRISVMLPNTDVLVEACVSAAMGIVQIYQVMKNLDDRPKRLPLLVHSTFQAALVLGIAYFAELDTKTLMEKTLRTAHDLLALFGKHDPLAQKSALIVEKLLEACELYAETGAAKSRQQQAQRVMHLFGDVDNHHLRSGDEGTALPRSHLRVDRCAGETAPAAVDASLQPLSQLEPIVAPGAFSEDSRDRQSELFPLASVDSNDSRRFVPDTFEFEFDDMGGFFMDLDQTIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP49</accession>
    <name>A0A1C1CP49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP49"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07816"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="86" mass="9248" checksum="DD871C02FBA8E039" modified="2016-11-02" version="1">MTAQGRKFGEEADPGVHGLPMPLWFWGLSRRFLAAFGNGMTGSQPRKRPSPLLSPEAPPSVSMSRQRLTVAGLGNAHPIAPSIIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP54</accession>
    <name>A0A1C1CP54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP54"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07720"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05721"/>
    <dbReference type="OrthoDB" id="4149611at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="151" mass="17914" checksum="73BA0B974EEF23E7" modified="2016-11-02" version="1">MSSFPSRPQHASVKTGSTQPEYTKYKSMKQFFDHKRLQLQQLTPTHFPFHDRIKPGTPGHRVLPFPASPPRVLHSPEEAAAEKKRRVNKKYLSILNPEWCLRRRQLVEMWNKDIHTRRQLKDQRRATPKMKALFREFRLSEVVNEDRESVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPQ7</accession>
    <name>A0A1C1CPQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPQ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CPQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07643"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05521"/>
    <dbReference type="eggNOG" id="KOG3328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="84"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="172" mass="19445" checksum="72B24F185F653BD3" modified="2016-11-02" version="1">MKKPEKFYTKDYMSRPGMSFAVDIEDPVERIQEFMNGYKREPVAEGFEESLMTNDLAIVGATGPPHVTAVFEMEMTPKYGSRMGNAQGAAISLIHDMCTTMAMAPLAREDFWHFGGVSRVLSVTYLRPTKTGTRVVVECEVLQVGKRFGVYRHSSARATSRHLLEQRRFEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR30</accession>
    <name>A0A1C1CR30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bro1</name>
        <name evidence="8" type="ORF">CLCR_07957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR30"/>
    <dbReference type="STRING" id="86049.A0A1C1CR30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07957"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09564"/>
    <dbReference type="eggNOG" id="KOG2220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09237">
        <property type="entry name" value="V_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="7">
        <location>
            <begin position="5"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="787"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="888"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="890"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="916"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="931"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="949"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="977"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1030"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1065" mass="117892" checksum="DB03BE2E3A9CDF70" modified="2016-11-02" version="1">MVQAPMISCPLKTTSEVSWVEPLSQYIRTSYGDDASKYAEEIGTLNRLRQDMRGAGADSASGRDLLYRYYGQLELLDLRFPIDEAHIKISFQWFDAFTRAATSQYSLAFEKASVIFNIAAVLSCHAAAQNRSEDKDLKTAYHSFQASAGMFTYINENFLHAPSIDLNRDTVKTLIHIVLGQAQEVFLEKQVRDGKKPALLAKLAAQAAFLYGQAKEGLESDHARGVFESVWLKLIQIKALHFSSLAEYYQALTEDETNQQGSAIARLQLAEKSSKQAYTFAKSFPATPSSASQLGSETASAMQSITRRQMETVQEKLASLVKDNDYIYHRTVPAEASLSPVTKVPAAKAIPLSELYQGQDIQRIIGPDIFQKIVPISVTESASMYDEEKAKLIRSEAEKVEQANGEMAASLDYLKLPNSLNVLKGGLEQEMGVDRDFEQWCQEIANHQSFNTAFEQLQKDKQTVLDSLAKSSKQLDMEESVCEKMRSKYGADWTQQPSSRLTSTLRADIKSYRDTVDEAGASDAQLFSTARQYESEFEEMRAAGEQGDADVLYQQALIKAGSGSKNRSKSGDETTLLDEDYGEGGLSVMDQIAKVEDLLRKLNLVKRERMQVLKDLKEKVHTDDISNVLILNKKAIANQENQLFQAELEKFRSHQNRLISTVHKQSSLLKELTKTYGDLLQDKRVRSDQQRYDAMQKSKNSVMNKYRKVFNAHEDLIQGLMRAQGFYSEMKESVDSLEKNVESFVSNRRAEGAQLLHSIEQTKNSSADGQAAAEQKRMQELMNRLSMEPKPTSPQQAEPPALPPLPPINASRSPGPVSPSYPTTNADPRFTIPPRHSPAPVVPNGYSAQLQPPSQPTNPSPIEAQHAFAQGAATPLSSAYNPMAYPERVTVTSPSQQPGAYTFSPVTSPLGPMNTYFPQGSQTHQPLAFASPSHQYSQYSFPPQPPSGPGAYQSPSPHPQMPQSQPPYHQHQHQPYQPSPSPYNMPQNYVPPPPPPGPPGGGSTTQYPTNPAGAWASGPGGYANYTQRYPQQQQQAQSLPLPQPGQPQSGGAQDSDPWAGLSAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRE4</accession>
    <name>A0A1C1CRE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRE4"/>
    <dbReference type="STRING" id="86049.A0A1C1CRE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08919"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09711"/>
    <dbReference type="eggNOG" id="ENOG502S13F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5422068at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32893" checksum="A08FA1AE81B921E6" modified="2016-11-02" version="1">MFVEVHRDPSSDASGDYVWAVILGVIDRIDGPGPSIDFGLERIVQHEFVGDTKDGGLACCLDQIDGHLVPFLLQGPDGVKVDGPAAELFKRLQQDGPDDSKTSQERTIQGSDTRDELSAECHCGGVNFRVTRPNMASKECSSPWPDLLVPYHLSSSENREDVKWWLRENDTKYLAGTLGSGSPIQAWAFIPKANILQSDGKPLDYEMGTLRRIESSSGRYREFCSICGATVFWHCLERPDLIDVSVGLLRAPEGARASNWLDWWTERVSFKEEAFDQKLINHLEEGLRNIRRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRY2</accession>
    <name>A0A1C1CRY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase HosB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRY2"/>
    <dbReference type="STRING" id="86049.A0A1C1CRY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07922"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06836"/>
    <dbReference type="eggNOG" id="KOG1343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09998">
        <property type="entry name" value="HDAC_Hos3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000011">
        <property type="entry name" value="Histone deacetylase HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053244">
        <property type="entry name" value="HDAC_HD_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="250"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="864"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1174"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1201" mass="128972" checksum="CAFD2C22D7B73EC9" modified="2016-11-02" version="1">MDPDIPAPSVEHDGSSDSNINATRTHSLASPSIKVNHHDHTHGHPSLLHSAAQVPLPPSSPMRSPYHTPAPPKTKSLSPKPPSRSPSVASSRGERQNTPPLRRSTSSLSNAKGSTPQYRRTSSNLNPLSPVINGKMSGTDRPPVTANSVARDYFGKEMEAHTSLQAPVLVLVHDSCYGHRFSRPRSTKSALATIVERPERIHATVLGASAAYVRLGGRHAEGEFAPRPKHDPSNVRNIPFQIRKTARIIPLTHPSVAFVHGSKWMEELQIMCDTAEGKLALNGKELVRPIGYGKDEAGHPLPKLHEGDLYLCAESLAAFQGCLGGVCDAVDTVFSSPLTKRAFVCIRPPGHHCSSNYPSGFCWLNNVHVGIAYAAMNHGLTHAAIIDFDLHHGDGSQNIAWDQNRKAHSAAKNAPAHKKTPIGYYSLHDINSYPCEWGDEEKIQKASLCIENAHGQSVWNVHLQPWKTHQEFWKLYETKYMILLEKTRIFLRHHTARLRASGNQQPKAAIFISAGFDASEHEGAGMQRHSVNVPTEFYARFTSDIAKLAEEDDLGVEGRVISVLEGGYSDRALTSGVLSHICGLASDTVTHNPLSSSTVGENTYQTINNWVDQVNHTSSEFTYSADWWTLQNLEELEAAVAGRQPSTAKSHKDKTGDYASPTQASTLKMTHHARERQSLSALQARMSLEAKYEPPPPEVDWAVAAYELSRIIIPSNRQTLSCTHEELNAEATKARRERQSAVGVPAPSDEPMQLRVRKAKAQPPGLPAVRSVSRNASRRTTIAAVSDLPDPTMKQPEVPYGRMRRRSSDASSILSSFQGMKLSDDKAGDNGSVPKPPAAQGPSRAPSVVPGQAGKPAPVRKPRVPAATKVPAKPKASPRKAKATVPPVPTIPSTTPAEAKVGNGIKRESSLSSQDVTKSAATSDSVENLTNGMKKISIKLKMPSAEEHDATLQQTVLDDKQKKPRAPRKPAVSKTTKVSEKPPAATPASLSENLVPVQPNPVQPGVRQLPEALAPQAAPSVISEKLASSAGPTSTDGTTEMVSENLELDIPPSSNAPQGAVPVADSRAPITSDLPVGLVMADPEPPSLNPFAGVPQAPVPEPFAGLENPTANTVTQNPLHEETDAESGLSAAPTSAASALSAAPNPLGATSPVQRTKHDLPLFTSESPIPFAVPTNNTNSESDVGSAKHQHADNTKRYAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSB7</accession>
    <name>A0A1C1CSB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSB7"/>
    <dbReference type="STRING" id="86049.A0A1C1CSB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08795"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06694"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF579">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G02250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="328" mass="36220" checksum="8CBB9159B66D258E" modified="2016-11-02" version="1">MSINHVLVTGATGFLGAHVVDELLARGLRVRAAVRNLAKANAMRDARPQYASKLEFVQVADFTANISFEEAVKDIDGIIHVASPLTFGVEDNERDFLLPAINGVTSVLKAAAQAPQIRRVVITSSFASVIDVDRKAPPHFTYTAADWNPLTYEVAADNNTSEVVAYRGSKKFAELAAWDFVHKEKPGFDIVTLCPPLAELNDSAAKLWEVASGVDPMPLARVPFWIDVRDLAQAHVESLLRPEVGNKRFTIASPERFSYQKAAEIIIKEFDWGHDRVHLPDTEQTIDQSHDLDGETAARELGITYRSFHDSVVDFVSQAQRLEASQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSI8</accession>
    <name>A0A1C1CSI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAUS augmin-like complex subunit 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSI8"/>
    <dbReference type="STRING" id="86049.A0A1C1CSI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08688"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06612"/>
    <dbReference type="eggNOG" id="ENOG502S4RN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5575722at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028163">
        <property type="entry name" value="HAUS_6_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14661">
        <property type="entry name" value="HAUS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAUS augmin-like complex subunit 6 N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="397" mass="44307" checksum="182049C9041AB457" modified="2016-11-02" version="1">MERPPAPHLQWSSRSNIAIFIHALHLLDLDLLPSWPGISESLFTSKSVQNPQARVKSTEWALYHLFRLYSPPDTQSRLAPHFPPTTSLQSKNLRAALYKWLAELKSTAVLPREAVLRRTMLDECKGDKFEEVLAKVAMVVLKKTLPSRNHERRTGERHVSCEQNVGTLVPLIMAHRVSLRQSLEARQDLKAKAMAFSERLAQLQQEILPELQNLQAASDGGDGAGQALPARDYESLRQQVDLAFATDRRWARYIFEGSAAGPGYSAVSAQKILPPWPLDNPSPTLDPGPAITTDDNASPLNMATAGSEEDADEPMRELQSLISQNQDRLEHLTRLQETLLWSTEPGSRPEDVAPELSNFAGAVDLHRHHHHPSATAQSISSAPKQRFNKHQELTLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSM5</accession>
    <name>A0A1C1CSM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multicopper like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_11362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSM5"/>
    <dbReference type="STRING" id="86049.A0A1C1CSM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11362"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06601"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13886">
        <property type="entry name" value="CuRO_2_MCO_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13910">
        <property type="entry name" value="CuRO_3_MCO_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="215"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="466"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="603" mass="66093" checksum="5C724F163D39869F" modified="2016-11-02" version="1">MAPDTFAEKSAPQEQPHTATSEGQGSPDAKDRGHQSNVSHRRRVYLAVVVVLLVVLALALGLGLGLGLNHSSKSNSGNSPGAPLPSNPRIPSEDSQASLSVPPWRANVEDYTLDIASWDFNAPPTTREYNFTLSEIQLSPDGVFRTMIAINGRFPGPLIRANMGDRLIINVQNNLANGTAIHWHGLFQNGDGPVGPLIIHSPDEVKMQKYYDVDQVVLLLDWYHDYSQALLPDYLASGSENGEPVPDNGLIQGTNYFNCSTLDSDSGYVCVQNSTRAVLTVEHGKRYRYRLINAGAFATFQFSIDNHPLSVIEADGTATEPLLVHRVDIAVAQRYSVVINATQSSASNYWMRAQLNTFCFGDDNPVLDADARALITYTNSTEVPTDSVDWKDALDVECIGLNSSQLTPMFETEAPPATIMYALAANFQIGDYAIDRAYINGTSWVMSDIPTLNQAVAGLGAANSNFTTSGVSSAFSANQYVIDVPDVAIVDLLITNYDEGAHPFHLHGHSFWILATSPDQYFDWSTYPALNTTLSNVLKRDTIMIDAYGWALIRFVADNPGLWALHCHITWHMESGLLMQFQTRNDIMKTWTLPSDVLALCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSV2</accession>
    <name>A0A1C1CSV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSV2"/>
    <dbReference type="STRING" id="86049.A0A1C1CSV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08948"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06507"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF13">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="286" mass="30921" checksum="CC7B2ACECD7E3C14" modified="2016-11-02" version="1">MVQDRASNVDKPVFVIVPGSFSPAPFYADVVDALRSYGYEAIVETLPSSARSPRRGEKAATMQDDTDFFHDIVEKLADQGKDVVIVTHSYGGVPGTECSKGLSKEERKAAGKAGGISRFIYVTSVVPTPGNSLKDLMGELVPSFINIEVSYASSEEGLVARTAERLISGTQGEFMSHVTEDSAKLTFSDLPFEEAKVWAERMSYHSASSFEGKLTYPGYNKIPVSYIFCEKDVILPPEFQRSVIAGIERESGKKVDVLRLSAAHCPNISAPQELAAIVVKAIATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSZ3</accession>
    <name>A0A1C1CSZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Virulence protein SSD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SSD1</name>
        <name evidence="4" type="ORF">CLCR_07905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSZ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CSZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07905"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06470"/>
    <dbReference type="eggNOG" id="KOG2102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903450">
        <property type="term" value="P:regulation of G1 to G0 transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000001">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000100">
        <property type="entry name" value="Cell wall biogenesis protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="3">
        <location>
            <begin position="748"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="605"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1192"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1202"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1215"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1239"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1263"/>
            <end position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1353" mass="148626" checksum="F39A53BAD4B61875" modified="2016-11-02" version="1">MAQPGQSGVPGPAGRRLHIAHRRSPSELTPLMMEQLALQQQIELLQQQQQQIAATHQQYVNMGMIQQPLQGMPAYSPVQGQPNLSSLSPNNNPNFQFPQMQQQMGIQGNPPTQPAAHRRNQSALPGMAMGPPPAPSAGAAGAAYGDFNQQALGQNRENTGGRGNPRGGSAQSGHTRRHSLALPEAKKAAELAEKKRTAAGFQFPIPGAAGTVESPVAATPSDDRLSTPVTPGGLGIGRAGNVRNMGHSRSQSMAAGGVRGGGAAGRGNGVFQFPPQGDAGAGNQSDLQRRGSQNSHTRQGSRNFEGNWRQQNNQQSNDQTQPQMGQFSQPQGMGFQPGHRNRGSINQSMGSMSGFQYPGQPQLVQLQQGQMMMPGFMPGGQQLNALQIAQLQALQGAQLGGLQASQHAPPMGLQQQQQRKTLFTPYLPQATLPALLNDGQLVAGILRVNKKNRSDAYVTTSDLDADIFICGSKDRNRALEGDLVAVELLDVDEVWGQKREKEEKKKRKDITDTRSSGPGQNGKSDTSSTTDTTSIAPDGSIRRRGSLRQRPTQKKNDDVEVEGQSLLLMEEEEISDEQKPLYAGHVVAVIERVAGQMFSGTLGLLRPSSQATKEKQEAERQQRDGGHSRSESRMQDKPKIVWFKPTDKRVPLIAIPTEQAPRDFVDKHMDYANRIFVACIKRWPITSLHPFGTLVEQLGEMGDLRVETDALLRDNNFGSDEFSDAVLKSVGWDDWSLKTETEESLRSRLDLRNERTFTIDPNGTNELDDALHIKQLDNGLVELGIHVTDVAHFVKANSLVDREAKKRGTGVYLMTRAVNMLPPKLCAEVCSLLPGEGRLTVSVIFKVDSETGQIEGEPTIRKSIIQSSGKLSFKTIDAVIKGGEQAGLEGATVDDIKTLHKMANKFREARFGNRSANIAPLRLLYQLDDENVPVEQNIFNTSAAHEIMEELAAKANFFVAQKIFAAMPDKAFLRRQSPPNPRRLLTFVDRMTKAGYDVDSSSSGTLQNSLFKVEDADLRKGMETLLVKTLQRAKYYIGNQIGDDHRQHFALNLPLYTHFTNPSRRYADIVVHRQLEAALSGGSVEFNEDLESLAKTAEQCNNKKDSAHAAQEQSVHIESCRLMDKKSKEIGGDLISEGIVICVYESAFDILIPEYGFEKRVHCDQLPLKKAEFRKDERVLELYWEKGVPSSAYIPEDERPRTSASTKGTNSATESARERAKERYESQRKQTDSNTMSTDDVDALFDDDEEDSTSELTEMASGVSLTNQGDRSTQSLPPSPSRNGTTSTGPARTQSDSRIAKAGGNIPENNLTDKEKYLSYFKLREEGGEYIQDVTEMTRVPVILKTDLTKSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT03</accession>
    <name>A0A1C1CT03_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c oxidase assembly protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">COA1</name>
        <name evidence="2" type="ORF">CLCR_09070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT03"/>
    <dbReference type="STRING" id="86049.A0A1C1CT03"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09070"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06468"/>
    <dbReference type="eggNOG" id="ENOG502RZQV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2100652at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="235" mass="25810" checksum="880AB83493EDC139" modified="2016-11-02" version="1">MNGKKLLTTPMALKQLQSLPPSLRQSILRAHHLRDAPLLPIPSTLIPRTLSRSSSSSSSPSTSPNADPGRIIRPLVPPPREGSGPLLSRRPDRALPDLPAGISVWLKTLPIFVLLITVSSLAIFNYEKSTSSTVNSILYALRTNIHARDLLGDEIYFASKLPWISGELSPMQGVINIRFRVKGTKGVAETKFVAVKRRGGFFETLEWSLRGDDGTEVQLLEKEGTTDPLEGQRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTS5</accession>
    <name>A0A1C1CTS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTS5"/>
    <dbReference type="STRING" id="86049.A0A1C1CTS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09200"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06228"/>
    <dbReference type="OrthoDB" id="5275938at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="171" mass="18777" checksum="2F6E89C95FF4B3A2" modified="2016-11-02" version="1">MLTDVVIEVDGERIRVSSKVMSLASPVFKVMFTSGFKESLTSRGTASDSSSISLPDDDPVAFLYLSKVVHFQDPKPPNNVDIVFFENLALLYDEYQCTARIASCVQAPLEKLAVSAPIDDLYKIILVACLLDAPHLCSSTSWKILVAQEGPFLAAPETMNHPRIPVFLLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTW8</accession>
    <name>A0A1C1CTW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTW8"/>
    <dbReference type="STRING" id="86049.A0A1C1CTW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09178"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06179"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="183" mass="18972" checksum="C16534669986AB93" modified="2016-11-02" version="1">MTKGIHSPWPTDPSAATGTSSYPSLYAYESSSNNPSIGQESGFGFSIQSVGTDTSPDTSNQDGSGSRQQSNHPTPSTLSNQTSAHTSYTSPPNQSGSSNPANSAQGQPSPGYIYSNTAFNINLPSQLGQGVSPQQSNLNFGSTGMTPGPTGMTPIPDALWPADGIPDGNEWMFSWPGSTPQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU46</accession>
    <name>A0A1C1CU46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">14-3-3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU46"/>
    <dbReference type="STRING" id="86049.A0A1C1CU46"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08627"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06118"/>
    <dbReference type="eggNOG" id="ENOG502RZWE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5370350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="397" mass="44178" checksum="FE0623D056E5AAE4" modified="2016-11-02" version="1">MDTDSDTDNDDAGMSELSPPSSALRRWKQGFVELTYLSRQWQPSSRDQSDPPLYSIWMASSEVDQKFLGYFAKVTTTENNYLSSFLFRVLGLSVILAEKLLRARRAKRLDPVRDPKARQLIHHILWLAREGLVMVEQYVLPMVGNYVELKVLSFKLKASFYHIFVLFHNEPPVNDRINRSRSFGGGDGSFTLFPEPLSPRESREGRERSSRQGTLRSPTEGNGTRRRSPAISTGRVMGATTTRTPPGLPLPATYPYFASGANGNGNGTATFLLPLQDYTPIATQAFREANELAESLLPGSHPVRLSVKVEYVAYVYDCLHEAEASRRMAKMSIRHVYEAQEGMDDDSFEDAAEMVGILGRMMKRGLGPGGSSGSQVKADGQSAGGRREQAQQPSTWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV48</accession>
    <name>A0A1C1CV48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV48"/>
    <dbReference type="STRING" id="86049.A0A1C1CV48"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10653"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03777"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="267" mass="30329" checksum="6AC5B91874EE413F" modified="2016-11-02" version="1">MSASDNDSALEALSAHSTRQDDGDDSDVNEADSGYWAREESTRSVTASVYDYERLHNRTYHAFHSGKYLMPNDETERLRMDITYHAFRYALRNTLFFAPITHPRAILDVGTGTGIWAMDAADAHPDAVVIGTDLSPIQPHFVPPNLTFEIADADEEWTFGRNFDLIHTRIMIDSSLRSWPHFFDEAFRALNPGGWVECQELDYNRRSDDNTIPADSRLCFWEREWTRGMEMIGMGGYCRPELVMEQMQHAGFITSSVAASNFQSVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV91</accession>
    <name>A0A1C1CV91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative histidine acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV91"/>
    <dbReference type="STRING" id="86049.A0A1C1CV91"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10010"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03799"/>
    <dbReference type="eggNOG" id="ENOG502RCH9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651076" evidence="3">
        <location>
            <begin position="18"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="486" mass="51466" checksum="9433FF2933119A70" modified="2016-11-02" version="1">MRSSILLASLASSTVSAETVLGVYIFSRHGDRTAKSTPPTELTDLGYQEIFTSGSYYRSRYVASDASRRIHGIAPDIVKLSQITASAPVDNVLQASGIGFLQGLYPPVGETLGSQTLRNSTVIQAPMNGYQLVPLQVVQNGANSEDAAWLQGATNCANAQISSNDYFRSSEYHDTLARTQQFYADMYPYVERTFAEDQTSFKNAYTIFDLLNVASIHNASVALPDDADFFQLRTLADQHEFGLAYNESEPIRAVTGSIIAAEVTEALNGTITGKGKNVLNIQFGAYAGMLSYFGLANLTAASTDFYGVPDYASSLVWELVTNATVSNTSYPTEDDISVRFFFHNGTTSNLSEPVEFPLFGSGRSPLPWSEFVASTAKFSIGTQAEWCTACGNSTGVCSPSALGEGDSGALGTGSSDTSSARHGGGGISKAVAGVIGAMVTLGVILGLEILFFIVGGFRLVSKKRLARTASNGSSAMTAGTGVETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVE7</accession>
    <name>A0A1C1CVE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09860"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03876"/>
    <dbReference type="OrthoDB" id="5139479at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="572" mass="62963" checksum="C55E770C2F3D7258" modified="2016-11-02" version="1">MSPSILDWVTISQLLCFTLQQVILRPTTRALSRIVIKLGGGQILRHRILTTITTGVFIGTVLFGDDSTLAPSRYLVRRFGSTVAVLRILQGLTSVLTTWVLSETLDLVQWTLVGREKGLRLLSLLSISPATGLSGMFMMIFLAKLPERAWAMARLLLTAMIWVAEIVLYYNIRVSTVYDAFSTWPVTAGAAPFDTSLAHERVAAYNGNITYQNLAFSNTFVTNSQFSIGSTPISCPGHCDSYILPGAVWSLNMTLPANSSDNTVVKIETSPAVQIDFFRGVDSADCLLPHGCTVYDENGSKIGIELCLAKSKVHEGSIFAGVTVCDQVLDGSCLYSARDPRHINTTFSLYSLTASTACTRANNSIISVTDIGEPTLEGIDIEGLDLPLGWLLNYTAQGIHAESSLVYMFWHGDPHPAARHDWSTATYLSLKSILAFSMYMFSVNGAGDPLRSERSFPSRFETTASLCRPLEKVIVDPGAYIAYIVLQSTVILFLWVVVVWRWSLKTPLQESSAFSLADFAAKFVRKEIVTESGQPWAFKRDFLKGAGSRKVIEVLSEARVVRQRLKMGSVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVQ1</accession>
    <name>A0A1C1CVQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVQ1"/>
    <dbReference type="STRING" id="86049.A0A1C1CVQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10772"/>
    <dbReference type="OrthoDB" id="10256793at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="235" mass="26520" checksum="21683776F431F094" modified="2016-11-02" version="1">MAWRYLLSKHERDHPKHVRPSSKDARFIPSHVDKQVENRRIPSSLKSLLALGEPGAGPILAEGISDSRSNAESSRRYTEEEEDMKRRYEREREAETQHGQGGDPVLSSRVSEQRNSDRNRPVAKRASVMLSACPACNGLGGRADKIRECTSCKELEKCFEHNTAVDKADIRAFQLLCEECNGQGTTIKEKYRCKVCNGDKVLPVSLPRDRERVSPAAQRNLRTTKRGMSILEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW28</accession>
    <name>A0A1C1CW28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW28"/>
    <dbReference type="STRING" id="86049.A0A1C1CW28"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10695"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04032"/>
    <dbReference type="eggNOG" id="ENOG502S7WN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5385072at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="265" mass="28190" checksum="E9F1C3790038BC6E" modified="2016-11-02" version="1">MHRQATTASATSLPRRSTSGRSTATNSPTSYVALMRRQKATVWCDRAQNIDPRLAAAQKAARHRAALEVQGATHGARTSTISSGGVVGKIRHGGVPKAPGYVPANLTGASVPPRLSANEALGDEEEEETRSNSMVHGRSGSGRSSTNSAKYRSGYPRPDAGRFSSTSTPPNEGSPGQGIPEASETPEDSHKRDYFEDKSPPGGEESEDSFGELRDLSGPSAVQRALEQAKKAEDLRRRGSVDERTMSMGQSGVRLFVANPDLDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWG3</accession>
    <name>A0A1C1CWG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Striatin Pro11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pro11</name>
        <name evidence="10" type="ORF">CLCR_09588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat striatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWG3"/>
    <dbReference type="STRING" id="86049.A0A1C1CWG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09588"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04128"/>
    <dbReference type="eggNOG" id="KOG0642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="747"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="574"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="691"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="46"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT52778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="827" mass="89581" checksum="99BA312C59A253A1" modified="2016-11-02" version="1">MAWQSGAGGGAVGGMAAGEATGVQAYTLQGVMRFLQTEWHRHERDRNAWEIEREEMRNRIAILEGETRTSKGMRVSLERHVKLLETALKKERERARNAGKGEPVDNHKDAKDLAREELKAAGKDLHIKAISHFDAEIDPDHHLAQGIRQEKERDKSKGFLTKCSSEITYHVLPTTHVPPETNELVPSTNGSHAFQGRQPTQQELQEAYLQLQQVKQQQHRNVAMVRENAVQQPTQYGEPNPITRTTTAINNSEIQPSVVDRRIPDQVVQSIPVVDPRKNFFNESMPVVEDPVESISHSFDAYGQEIPLKDHTDMRTMDEPKQEVSDGWDFDDGPPASEKPVEVPPQRPDTELFPSANLIPSKSPPRAPGSYRRKSMGGRRRSEGSNDAKDLGVKSDASQFKVRFAMRGHLDVVRAVVFTGGGSPSEPEFCTASDDGGVKRWHIPATYTHNVALGDDLDRIAHFTHRGHLGAVCSLAACPASLSFSSGGRAAGDGWIFSGGEDATVKVWERGRVDAKATLEGHKDAVWALCCLPGSTGTILGDRCSQFGGPDRVLLVAGGADGTILIWSVSTPPQLTSPHAGSRSARGSRRANSISAGSNFPSSPQPSIASATPFNYSLVHRIERADKPAPTSISPLGNHGESFVVGYTDASVLVFDTRTGEEIVGMASQETYDGTPNTGINAVVASSTGFDTRDSVAPGRRGSMGEDDVVHGATGSEGGVEGVVIAGYEDRYIRFFDANSGQCTYTMLAHPSAISSLSLSPDGKELVSGGHDASLRFWSLEKRSCTQEISSHRIMRGEGVCGVVWSPDGRWVISCGGDGAVKVFSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWL1</accession>
    <name>A0A1C1CWL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10802"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04285"/>
    <dbReference type="OrthoDB" id="4148201at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="222" mass="24851" checksum="C8146A0D092C33DB" modified="2016-11-02" version="1">MTRQKAQGEKDGPPGDSAQAAAPSELRQDHLQSASSDPVASLVCHPRKSNIFHRISFGRPQGIKELAVKDLDNRKRAEKADVKARKDAASWERKARKNREAKDRDERKRASRVRVKQNKKDKALRHAEEKRVEDYYGIRGYDPNAGMLRSNREGPMTACAEQGGQVGQERQGPLSRRLHVEQTWGFEYGKPKQHDGKGHYSGNHENCGEHYGSSAAAISDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWM6</accession>
    <name>A0A1C1CWM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitroalkane oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_10229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWM6"/>
    <dbReference type="STRING" id="86049.A0A1C1CWM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10229"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04244"/>
    <dbReference type="eggNOG" id="KOG0140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10016597at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046359">
        <property type="term" value="P:butyrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="5">
        <location>
            <begin position="261"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT52904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="434" mass="46568" checksum="4F551972C2AB3E88" modified="2016-11-02" version="1">MIDFELSQEQLAVRNGVRGWAKANLTSARSVYEGQAASTGEWRARFRSTRPIYAEAVKAGLIKAQIPKELGGAGGPLIEAALVVEEFYAVETSASLTILGTGLGLTPLIMAGSSEQHQKFFKPFFDGIGTPLASLVFSEPGGSANFAEEGSPGFQTVARAEGDEYVINGDKIWATNSSGWDDRGADVQCVLARVVGSAPAGDVRGQTAIIIVTREDIATNDPGAYQVLYHPESIGHTAVNGPHIRFKDLRVPKTNLLAPPGKGADVVEMTFTASACLVGAMGVGIMRQTFERALAWAKTEKRGSKETMLKKQSVADLLIKIKTRCEAARALVWKAAHAFGRTQYGAELCYEAKIFGSESAVESVMDAINLIGVSAYSRKQPFGDLLNDAVVLPIFDGGNVGVRRRQIEAIFLKEGYDPWETTYGADERGPAMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWU2</accession>
    <name>A0A1C1CWU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_10684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWU2"/>
    <dbReference type="STRING" id="86049.A0A1C1CWU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10684"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04362"/>
    <dbReference type="eggNOG" id="ENOG502RZAN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4863010at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43167">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43167:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13578">
        <property type="entry name" value="Methyltransf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="230" mass="25497" checksum="A993EF354175DD1D" modified="2016-11-02" version="1">MSYQFPNPVEASDHVLALLDRLHRHSEAQEAGFDIYKHSASASTFKEAVQDKFIALDQDKCHCLYTLCRALNAKNIVEAGTSYGVSTMYLGLAVTRNIEATGGSGTVIGTEHETSKAERARAYWAEAGEEVSRYIDLRVGDLRETLKSDLPAEIDLVLLDIWAPMTLPALKLVQPKLRYGAVVVIDNPIASADRYKDLLGYLRGRDSGFINLTLPYNKGLEMSVYVPSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWW1</accession>
    <name>A0A1C1CWW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWW1"/>
    <dbReference type="STRING" id="86049.A0A1C1CWW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10886"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04269"/>
    <dbReference type="OrthoDB" id="3183782at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="158" mass="18264" checksum="A22459650994BBD3" modified="2016-11-02" version="1">MATKQRLVKLSLFAKRKSHLTEDEFHRHWTEKHRALVLDWLARHGIVKYTQRQRTAHRIPGRHAPADAVGQYHTHSSAATAAIADFPALGGLKKLDFDGVGEFLMLDASCFQKAREDPYYEQFILPDENQLFEWESAQWTVGWEEVYIKDGKIVEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX35</accession>
    <name>A0A1C1CX35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PQQ enzyme repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX35"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10622"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04290"/>
    <dbReference type="eggNOG" id="ENOG502SHMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202289at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="296" mass="33649" checksum="43B6B8DA13BBC4F6" modified="2016-11-02" version="1">MWQKYRGGVMMQVDPHGKVISEYRDPLAHHDQHHLDNGHLLYTTVEALTPEQALTIPGGIPGSEAPDGSVFADCIKLVDPADHGKVLFHWRAVDHLDPEKFPLHPHFAREHWPLINSVQLLKDGNILASLRSVSAVVVISRETGEIMWHLDSTVVAQQHCASELDDGSILIFDNGTFRYRESSTYSRVIQVDRATKKLLWEYRDRSMPNAFFSPFMGGAQRLENGNTLITEAVFGRMFEVTPEGQICFEYVNPHFADYKHLNAPELLDIGFDFPANAVFRAYKYTPDEVPWLRLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX98</accession>
    <name>A0A1C1CX98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative kinesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_09457</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX98"/>
    <dbReference type="STRING" id="86049.A0A1C1CX98"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09457"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04349"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04350"/>
    <dbReference type="eggNOG" id="KOG0242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.320">
        <property type="entry name" value="Photosystem II 12 kDa extrinsic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="475"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="817"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1030"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1030"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1061"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1090"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="562"/>
            <end position="569"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT53010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1199" mass="132199" checksum="9ACC117FEE5FF752" modified="2016-11-02" version="1">MTSPVNEAGSQTSQTPSLSTTTSMPPLQCNATSPDPTKSPEAVAMPPVDGTVPLVEVEPYTRTVQLDMLRDTPTTPSTGGKSRVSRWGKAAATSGYLDPWYSKSGRCSLLTLLAAEEYPAGYPSLAAYMSDDIDGRIYRRFSYLRNRLLLYMQDKLNALEQALEDVDRDDEEKAKNGEREALYRLISRRYNEQTANLTPGVGTPPCPCCHNTANQQALPGNAAQTTNSPHVSSLSQPKNNATKRMEILEDVEKTLEKYDELLLREHEIASIRESTAKQRASLGNFIYNGKKCGPGKNKKPLANQENKLIYRKDDSVLLGTQEDAWLGTAAESMKRLMPAILRRYLLMTREDREKSTASTTEYLSNHRVNSFVKAVVSVASTILLVLPIIILYALSTHGASGWLKIGILLVFVVAFALALAMLTNASRSEMFGASAGYTAVLIVFLTFTGSAQDVEPALAFHPSIDTQPSRAVKMSVRVVARIRPLLNSEIEKDQIVTSQPGPDGKATIVKIPNPKNFAEEYSFQFNSVYEQDATQQVLYDAEVAPTVKHLFLGYDVTIFAYGSTGTGKTHTMRGGKSLADRGMIPRLLSSIYRKSRALEKSGGGETTVDVSMSYYEIYNDRVFDLFEAPEKRTPTGLPIREAEGGKAVVVGLTEVPCSSLKEFEVLYDKANANRSTGATKLNAHSSRSHAILCVKVTITTPTETRVSTASAIDLAGSEDNRRTGNGKDRMVESASINKSLFVLAQCVEAISKKQQRIPYRESKMTRILSLGQNNGFTVMILNLAPVKAYHLDTLSSLNFANRTKKIEVREVENEPIFKGPPRPVAPVGGPTIQRQPLRPLSNSINVNLAANRDAATKNEKPQKAFAVYSDRNKAAMARPAPQKSSPLKRTADTSFFASTRPAKLPRPTPSFIRRALEPQLPGMDKASIEALVEKKVSEVLAARAMNAPDPQPMKAVSEEVQRRLDSIEKRLEGQDGERAEGLSYLLMAKQHQARGEDGSALKMYELARPYFPDNEKLKGKIERLREKLVAKRREGGEPAEKSEQIPATSRTVDQAKGPRADDEDESYQDEGCDSTYNDSGDEDKPTDRSRSKKQIKQQLKRKARVSSPDPLSSQDPEVIVGTLTPRTRYLLDIVNTRDVAQIKTLHGLGAKRAEGIVEYLNEQTGDSDDGFVMRSWDDLARLRGIGKKTLETMREGVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXP5</accession>
    <name>A0A1C1CXP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Catabolic 3-dehydroquinase</fullName>
            <shortName evidence="3">cDHQase</shortName>
            <ecNumber evidence="3">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-dehydroquinate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">qutE</name>
        <name evidence="5" type="ORF">CLCR_10816</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXP5"/>
    <dbReference type="STRING" id="86049.A0A1C1CXP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10816"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00282"/>
    <dbReference type="OrthoDB" id="8191625at2759"/>
    <dbReference type="UniPathway" id="UPA00088">
        <property type="reaction ID" value="UER00178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019631">
        <property type="term" value="P:quinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="entry name" value="Dehydroquinase, class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272:SF5">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="Type II 3-dehydroquinate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="216" mass="23891" checksum="E19DD7DE1989A289" modified="2016-11-02" version="1">MSTPPSLSLRRKILLINGPNLNLLGTREPTIYGSTTLPDVVASTVSLGRTLNVEVHPFQSNHEGQIVDFLHSHFVDPGMSTYESEAAPKDGDHTRVDTRARTAVIINPAAFTHTSVAIRDALLATGFPFVEVHISNVHAREEFRRHSFFSDKAVGVVAGLGVRGYRAALEFWAAKWDQEDEDPGEEDEDGDEDAKRRNEQEENLKVGSGEVLKERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY87</accession>
    <name>A0A1C1CY87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-xylosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_10322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY87"/>
    <dbReference type="STRING" id="86049.A0A1C1CY87"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10322"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00350"/>
    <dbReference type="eggNOG" id="KOG1066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10070917at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051816">
        <property type="entry name" value="Glycosyl_Hydrolase_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863:SF2">
        <property type="entry name" value="MALTASE-GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="4">
        <location>
            <begin position="288"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="43753" checksum="77B6CDEEF1587DD5" modified="2016-11-02" version="1">MINELQSMDVQLLVSIWPTVDKRSENYDFMLEQGMLIRQDRGLRISMDFQGETVHADFTNPATREFVWRTAKKNYYDKGVKMFWLDEAEPEYNVYDFDIYRYHSGSVLSSGNAYPVEYARTFFEGMRQDGKQQEICNLIRCAWAGSQKFGTLLWSGDIASSWESFRDQFAAGLNVGIAGIPWWTTDIGGFHGGNPQHADFRELCTRWFQYAEHEGAGCFCPVFRLHGDREPKQPQHGTTGGATCLSGAPNEIWCYGEECYEIMKKYLFLREKLRPYVRGLMTEAHEKGTPVIRPLFLEFPQDKECWELEDQYMFGGKYLVAPVMYKGMTKRKVYLPKGAQWKRFDDGQVQNPDVLKGGVVTEVDCPLAVMPVFERMDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYS9</accession>
    <name>A0A1C1CYS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteasome activator subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYS9"/>
    <dbReference type="STRING" id="86049.A0A1C1CYS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10812"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00638"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="2">
        <location>
            <begin position="131"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="218" mass="24337" checksum="C2CC9561AA791E60" modified="2016-11-02" version="1">MIDALIRIGRTSSSWHQRLRVMINMQIIFFRRLFLLSEESKQKLFNCVADMLEDTQHEVRAGAATTLSGMIRCSPLGLRERMIKQLRDRFTQTLINNPLPKKPKGQLAGLSSARTSGTNTPSPEAQRLVVVRHAAVLGLGALIQAFPYTSPPPAFIPELLVQLSSRAANDPGTVGNAVKSIIADFKKTRVDTWFEDKKIFDPETLETLAGVLWKSYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ38</accession>
    <name>A0A1C1CZ38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_09537</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ38"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ38"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09537"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00731"/>
    <dbReference type="eggNOG" id="KOG0683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3364440at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383:SF2">
        <property type="entry name" value="AMIDOHYDROLASE 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383">
        <property type="entry name" value="NODULIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="4">
        <location>
            <begin position="646"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="977" mass="109254" checksum="4753B15FFFCDAD61" modified="2016-11-02" version="1">MAPQPELYPALHRVRDVESAGIQDLQQIIQTFPVIDNHAHNMLTEDNAYGGAEHPFESITSEAQGAALTDHVHTSLAHMRGVKHLAEFYQCPETLQDVKAARYEWVRRDYPGLIKKCLEGTHAIMMDDGLSPELIHSFKWHRQFVPTVSRIVRIEAVAAELLEHLAHAAGFMRVGLDADWDISQTESFLVRFNTVFRNQVRTLANDPDVRGFKSVVCYRSGLDISLESRKNFRPHQSLTESALLQSFHSFLQKAVRDHKYRIQQKEVNDYLVVAVCDVLEKLVDTEGESLPFQFHTGLGDTDINLVKANPAYMQPLIEAFPQVDFVILHSSYPYTREAGYLAANYSNAWLDIGEAFPMLSRDGEESILRQALELTPSSKILWSTDGHFFPETYWLANRHFREALERLLTSYIAAGDLTVAQAIDMAVDIMFWNSNSLYKLDEERKYPELLRACGREAVDSMRTLVNGGSKAPSFRSYASTAVAMPGASSARAGPSLSTATLPMASHSLPLRMGSASAPSGQSSTALLAQNVTTFDTFLQANAGVKYIWVQYLDYTGTLRNRMLTTQQFRKQLSTGKALACTSALTRLLQDDNPATGCCATGQFLLAPDLSTLTLNKGIDSPSATVQTWWMADSEQVPLVEHYDRCPRWLLQSQCDALKAEFNISMLMGFELEIIFMQPVMNENKTDFVEFEPLHMVHSWANMTWQQLDMLPIIEEIVSHLAEIDIHLPQFHSEAAPGQWEFPLPPLEPVQAVDALCKTKDVIRNVAKKHGLKATCYPRPYSFSCGSANHAHFSINGPGDTVEKYEAPFLAGVLEHLPALLAFMLPVEESYQRVHAGIWAGGEYVCWGTQNKEVPLRKCGPGHFELKTIDGMGNSYLSIAALLAAGLHGLRQDLKLEHKDCAGDPTGIGEEERQKLGITTQLPNTLEKSLKALDRDKVLRRGLGYAVVDDYLAVGESLMAKLRGFGDVKRRLWLMARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZJ9</accession>
    <name>A0A1C1CZJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo-keto reductase yakc [NADP(+)]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yakc</name>
        <name evidence="3" type="ORF">CLCR_10440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZJ9"/>
    <dbReference type="STRING" id="86049.A0A1C1CZJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10440"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00821"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="344" mass="38590" checksum="D05EFF243776203C" modified="2016-11-02" version="1">MAPQLPTRKLGKNGPEVTALGFGLMGLSAFYGTPKPDEERYAFLDHVYNSGERFWDTADMYGDNEDLIGRWFKKNPGRREEVFICTKFANYVDPKTGERSVKNEPDYIRQAVDKSLSRLGIDQIDLYYCHRVQANQPIEITVGVMKELQDAGKVKYLGLSECSAETLRRACKVVHIDAVQIEYSPFSMDIESPQINLLKTCRELGVAVVAYSPLGRGFLTGSIRSRSDFEEGDFRTFAPRFSEENFPKNLKLVDDLKALADEKGCTPGQLVLAFLLAQGDDIIPIPGTTKVKNFDENMAALNIKISREDNEKIRKVIDAAEVHGGRYPEAFAKALFVDTVPLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0I3</accession>
    <name>A0A1C1D0I3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative serine/threonine-protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_00230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0I3"/>
    <dbReference type="STRING" id="86049.A0A1C1D0I3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00230"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09463"/>
    <dbReference type="eggNOG" id="KOG0661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000233">
        <property type="entry name" value="Meiosis induction protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000314">
        <property type="entry name" value="Serine threonine-protein kinase mak"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="605"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="687"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="616"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="793" mass="88480" checksum="82805BD22583E338" modified="2016-11-02" version="1">MAVTEYSQRPASYALVALEDRFEVIKDIGDGSFGSVALARVRANGASVARRNTMVAIKTMKKTFESFGPCLELREVIFLRTLPNHAHLVPALDIFLDPFSKKLHICMEYMDGNLYQLMKAREHKCMDARSVKSILYQILSGLDHIHNHNFFHRDIKPENILVSTSAPQDSQSTFSRYSSLVTPPSTPPTYSIKIADFGLARETHSKLPYTTYVSTRWYRAPEVLLRAGEYSAPVDIWAIGAMAVEIATLKPLFPGSNEVDQVWRICEVMGSPGSWYTKTGNRVGGGEWREGNKLAQKLCFSFPKMAPHAMETILQPPQWPLAFSNFVTWCLMWDPKNRPTSKQAMDHEFFVDAVDPLRPKSSSRLLGRKHSDLSFRSKDAADTPTITSKPSWFRRSLIARESAPAVPQHTPEPKVVQQEPEGLVSRLRPQASKRATWTNGTNSNGAAPMPILPSIRPISPLPNAVTAQASSTYVSSSESKHESKPAEEKSKKIGRQLSINSHGNHYADLHRQEAERALNANSGLVSPPSGQKESFFSHLRKRARRFSGRHGLASPSGDDVEANAANVPWSNRSSLMVDSAIPEVNHDFSDLDKILQNVRYSLDRAEPEMGHRKSSTEVTSNQGSLKRTHSVPRSQGSRSSENLAQVPAPTNNRISRRPIAINQYETPEEADELLDEALRSAQRAVRRLDQKGYPKDQAQRHALAQKDYNRQSLPQIPSNPALHGAYLTPSPSAKRDGVHFNSNTTSTVQPLNITKKRSEHDHVPSHWPTPPYEENDWASAAANSILATGQMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0S0</accession>
    <name>A0A1C1D0S0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0S0"/>
    <dbReference type="STRING" id="86049.A0A1C1D0S0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00839"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01604"/>
    <dbReference type="eggNOG" id="ENOG502RXQ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="95"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="502" mass="54250" checksum="2AE9941E66CECED9" modified="2016-11-02" version="1">MGSIDPARTFTPEELPPPWKLTPADITIDNHKDGDKGKILFKNVNIFDSTGADIYPGDVLIEGERIKQVGKVDVAPDEDDDDDILVIDGKGKKTLMSGLCDAHTHLSWNNSPTLDGLTGLKLEEHVLFTAQSAKTYIDCGYTMCFGAASAQPRLDIVVKGAIKSGMIPGPRTLASCQEITTTGGAIIPSISRYADGEDAMRRTVREFVELGADNIKLSMTGDYVHPTMGSTETYFTLKETKAAVEEAHNRGKRVCAHARSAASVVLCCQSGVDVVYHASFADDKGLDMLEALKDRVFVAPAINFPYNTCSGDAIPYGMTPEMAKKKGLVEEVERACKAMKELHRRGVRVLPGGDYGFAWAPHGTYASGGRPRDLAHFVNLFGYTPKESLIAATALGAEIMGHPDVLGKVQPGYYADVILLDGNPLEDIDIFQDTSKLHAIVLNGHVHKNVAVAAADGQSLTADGLANKRTVYTNLPLVPKEEQERQQRDAQENGIGVEPQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0S6</accession>
    <name>A0A1C1D0S6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0S6"/>
    <dbReference type="STRING" id="86049.A0A1C1D0S6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00982"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01593"/>
    <dbReference type="OrthoDB" id="5429174at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="130" mass="14216" checksum="064595CB7FDBBFDD" modified="2016-11-02" version="1">MSASRAIGGSSRLLSTVVRSQSSVAARQWICRRCASTAVLQNLSAGHRSQAVQWPLDRRWQQRRGAAAAAAAMLEEAQDDPDSLSQETIIHNLSPEEAHRLSKVRNIGIAVSRSLQFYAPERFLIAAGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0T2</accession>
    <name>A0A1C1D0T2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0T2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00346"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="135" mass="14435" checksum="5FFC0A7825617D9B" modified="2016-11-02" version="1">MLEGWSRRGGINSPETHGRLQPAGTGCCSRKEIDLAKSPKTEASRRSQRKAPSAPRAQKEGGPGTPNKNKFGAEQGSKTHIPNSGALGSPETKLRPGPWNKAHGANGGGRIRPSFSTDALKDQLTREEAEVPKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D164</accession>
    <name>A0A1C1D164_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D164"/>
    <dbReference type="STRING" id="86049.A0A1C1D164"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00857"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01725"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="133"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="467" mass="50594" checksum="50366CBAF3A22120" modified="2016-11-02" version="1">MAPAHTPIDRFLQGINTANLELMLSAFASNAEVIDNGKSFRGDAIRDLCERGIIGHHTEVNVLEQEHPGDGRAYVHVTIDGDFGKDFGIHDPFELFLAAKFDNDKIQHLEMGDLNPKRPAMRAVYASVGNPTDPLSSIRIDRRNVPEVKEGYVRVRMQAVGLNFHDIFTLRGVGMHEIRFPMILGNEGAGVLDDGTEIAIFPNLSTDPDFKGDETIDPHRHVFGELVQGNLAEYAVIPKRNAVPRPNNLDANSASVMGIAWLTAYRMMFNRAHLRAGQTVLVQGSSGGESTLDTTSVICVRSLELMCYTGVTTALIQMGSAAGYRVWTTGRTGAKRALAQSLGAEQTFEPLARLPNLVDAVFDTSGAATLSHSLASVKPGGTVVSCGIHSDGGSTDVAINLMHLFVNQISLTGVYTGTREEFVDLLNFVSAKGIKPYIGKVLPLERAGEGLRDIWEGKTDGKIVITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D185</accession>
    <name>A0A1C1D185_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-oxo-5-alpha-steroid 4-dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_03017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D185"/>
    <dbReference type="STRING" id="86049.A0A1C1D185"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03017"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04734"/>
    <dbReference type="eggNOG" id="KOG1638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF43">
        <property type="entry name" value="STEROID 5-ALPHA-REDUCTASE DET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="139"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="314" mass="34910" checksum="D5075AC6BDC7FF4C" modified="2016-11-02" version="1">MASYLSNLPSVGEFFPPTPRAAKLALDIFRLYIPVSIAQWTPLSRLQAMGKTSYATSRFNLPGRYAWAAAESVGPINLIYILAALPSKLRPPQELATRILVLGLPVQNVILACLYLLHYINRALVSPLYLNPSMSPIHVFVTIFMMVFQFTNSTSIAAWLVYSVLDVEAGSRPIVSFGSIVGITMFLLGLAGNIWTETRLYEMRRGAARRKAKAEGKAVVTYDKVYVIPPAAGFFKHILYPHYVLEWLEWSGYWLLGGVWGLGWGSRSAAFWFLMCEIATMLPRAVAGRKWYETKFGKRAVGGRAAAIPGPIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1F2</accession>
    <name>A0A1C1D1F2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 25 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_02928</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1F2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02928"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04753"/>
    <dbReference type="eggNOG" id="ENOG502SHN6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT54649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="404" mass="44323" checksum="BD88CDDE2E1F2A80" modified="2016-11-02" version="1">MIQAFRPHSVIGSLSRLSTTQPSRVSVVAFASLMGFLLLLIGYHNSSTYVTTWSSAVSASASDRGTISPARQKSLDAIQNTTLGFEKILAINLPERTDYRDGLTLAGAVSNIQVEFIDGVHGDTVLDKVLPPKHVDNPEAALRGSWRAHVNALRSVVEHNWTTALIFEADVDWDVRVRDVLTNVALGSEALLSLPARGVQDQRFQLSRLSFPAAVAPPLSPYGDGWDLLWLGHCGMQIRGGSNVVVIEDEDTVPEARFVRTWDSTERSPLEEYPAHSRIVFHTDDCVCSIGYAVTQSGARQLLNSLGLHRLNAPVDIMLREWCGGREGDDPHVCLGTLPTVFASHRPAGSTAGDSDMGTPADGFRDRGFTQNIRWSVRMNMDKIVRGDTDYEDQFPDTVNELVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D281</accession>
    <name>A0A1C1D281_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="3">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_03012</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D281"/>
    <dbReference type="STRING" id="86049.A0A1C1D281"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03012"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04954"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000010">
        <property type="entry name" value="Acyl-protein thioesterase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="13">
        <location>
            <begin position="5"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT54862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="233" mass="25668" checksum="4D1EC77C6CB61ECF" modified="2016-11-02" version="1">MAGKHALIVPALKKQTATVIMAHGLGDSGAGWVSLAETWRRRGKFEDVKFVFPNAPNIPITVNFGMRMPGWYDITDFSDLKQAHDEPGILRSRITFTKLITDEIEAGIPSNRIILGGFSQGGAMSLFTGVTTPHKLGGVFGLSCYLVLGDKIKDFAKEANEANKDTPFFMGHGDADEVVKYTWGQQTAEVLRKELGHKVEFKTYRGLPHSAVPEEIDDLEEFIKKCLPASESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2K6</accession>
    <name>A0A1C1D2K6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GTP-binding protein rhoC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rhoC</name>
        <name evidence="11" type="ORF">CLCR_03054</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2K6"/>
    <dbReference type="STRING" id="86049.A0A1C1D2K6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03054"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05106"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT55016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="271" mass="30745" checksum="6F5F1E9E3DD2FF78" modified="2016-11-02" version="1">MADTDHYPSRTPTMSEKTPSSYITPPSPKRRPVRAPSTRTSNGTVSTNMSYGSVGRLSEATNITQPPSYSKKFVVRQERRALYRQDERLIKRPQKYVPTVFENYITQTTHKPSGKTVELALWDTAGQEEYDRLRPLSYPETDLLFVCFAIDCPNSLENVMDKWYPEVLHFCPTTPLILVGLKSDLRTKRTCIELLRTQGLTPVTPDQGAAVAQRMGAKYIECSAKENKGIQEVFDLAINTAIQMEEESYEAKPDKKGVKVKKAKKRKCVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6D4</accession>
    <name>A0A1C1C6D4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_00125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6D4"/>
    <dbReference type="STRING" id="86049.A0A1C1C6D4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00125"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02027"/>
    <dbReference type="eggNOG" id="ENOG502SH72">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2107885at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF1">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN RRT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT44021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="264" mass="29668" checksum="04B3B17D30BD131F" modified="2016-11-02" version="1">MASSVLDVVWLYPLKGILYFIRHPYLFPLFKARLVPIFLLSAFIYANLFIWAYLPQVAFLAIFHGPGAWLNATFLVLGEGAAIVALLFEAFFVDETLVDTFDAVLIDQGLADLVGQGRLLDPAAPNSVQMLGKPTTSAIYAPFSLRQIIEFVVLLPLNFIPIVGVPIFLVLTGYRAGPFHHWRYFKLLGYSKKERQEYIRNRQLKYTWFGVITLTLQLVPVLSMFFLLTSAAGSALWAAKMEKARRSRDNATISGPEPYQDNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C797</accession>
    <name>A0A1C1C797_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_05445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C797"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05445"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07036"/>
    <dbReference type="eggNOG" id="ENOG502RXKS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5376052at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF28">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT44339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="796" mass="88689" checksum="66DCF34EAD64835D" modified="2016-11-02" version="1">MNAAKLELYDHHAGNEGEANGASTHLPPSSNSPSDYDSGGDDDLDGSLRRKRKRVSRPMNVTCEACKQRKVKCDRQQPACGWCTRNDHPCEYRERKKPGLRAGYGRELEGRLDRLEALLEEQGRQLAAHLAESCSISGVTTAASNRSNAQGVGPETARPQGSYNAQGISVPGELQQQIIDPSLHPPGSRHGSLQYQQSVADQQIAQQSHYTPSSHSHAALTSPHSTTGYPATQVFNEYSAMLPPYDLLYSLVDLYFKHINIWLPLLDRKTTLDTLFGASTLDEADRVLLHAIVAATLRFSQDPRLTPEARQHYHDTSKQRVQLFGLENSNVRALQALVILALDVTGTTNGPPAWNLLALISRSMVQLGLAVESGSVLATPMYPSIATLRASVLPEPKSWIEDEERRRLFWAVYLLDRYATIATAFEFALDEKEVDRRLPCRDDLFAANKPVETRWFRPPEHPRYATGMAVGDTHGYFSYHCELMAILGRIHQFLKRPVDIGSLPDVEQWQGSYRALDSDLNAWHFSLPDDFANITRLLKSNVPAKNTNCGWIMLHAAYCLTVIRLNSSAAYPSQTSPIFCSSYSAMQRCLSAVENLRKLCRFVKLSGLLDKVGPPFAFAIWVGARVMLVHGSTMDHEVDPDIDFFVTALSEMGENWLVARRYSEILSRVLGEYRQSHRATGVTGERVTPSTVKILADMRRCAYDLDFLISRQPHAAAVKSYHPTRANTPAPNELEYLDVFDLFNFPRIPMTQEGVENGNAQAMGQAAPPDLSAMNAAMIPNFAVPNPEADWLYHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7E3</accession>
    <name>A0A1C1C7E3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7E3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06500"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="72" mass="7655" checksum="59526F4AEE64A1BA" modified="2016-11-02" version="1">MTLPTYPTPPSDQVAKQTAAGRMVPAGTISEEGLGMRRDDGANEQTSEEGHLKEIGRSESNCILHALSQALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7H2</accession>
    <name>A0A1C1C7H2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7H2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06295"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="171" mass="18574" checksum="BDDD51BEE532D074" modified="2016-11-02" version="1">MTSLKVEIVISVSGNGEVEPPNGTGENGRASRLSSLSTDHPLVNTTNEYFLAQHQQYEENQDQDQQRHPRFQSVLTPLRDAGKDVNMSIAGKPKREAQASTRGPHGEDVVGMMPFSPHGGAPHRHQQHDGDKDPLAEEIEELVRLARAEAAGAVEDPGHPASQVVHGGQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8N1</accession>
    <name>A0A1C1C8N1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8N1"/>
    <dbReference type="STRING" id="86049.A0A1C1C8N1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05985"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07494"/>
    <dbReference type="eggNOG" id="ENOG502R4J4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310870at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF5">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43931" checksum="47DC9C7D0FADC807" modified="2016-11-02" version="1">MAATTNPQTPRSTKFQLRMEDDVPIIDSRETFSDVVFKLSSYIAKAIDTPFTYEQLRTTVAGQSLRPLVSNLSEECHHPAVVAALLAARYLFINDQGDVDAGLNESRALACELVAWQFLTFLSEKELIDYLLYELPEVSEDNTHVSPSETYTNSQHATNQNDDGSSNESSPLLRSRSSDHGNFLRPPRRASTQHTDRFTSGATTSTFGGDEDDASRRADLDESMAGMNALEIAAIGDAKKFISQSPVQKIVEDIWNGDVIFWESLSVHAVKKPRAYNKRVADPFTRLRVPKYQKAFQISFFLAFLVLYYAVLVERNPGHITPTEAVLYVFIAAFAYDEFGEIKDAGIMFYQTDFWSLWDIAVGLSTSGSRNDDSNLDRIVRPREESTPLDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8P2</accession>
    <name>A0A1C1C8P2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxypropionyl-coenzyme A dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8P2"/>
    <dbReference type="STRING" id="86049.A0A1C1C8P2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06194"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07502"/>
    <dbReference type="eggNOG" id="KOG1679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="277" mass="29533" checksum="AD7380BE8929B2AF" modified="2016-11-02" version="1">MGGPVDDTASVAVSFSERRNDTVATLTISNPSRLNSLNSTVLDAIVSSVSSLSDHPNLRCVIVTGALLQAKQQAFIGGADISEMSTLPDAEAARRFITKIHLACQALRDLPVPVIARVNGHALGGGLLIAAAADLRVARSTALFGMPEVQRGVPSTVESALLPAIIGSARARRLLLLGDMIPAAQAESCGLVDRVVQASELDDAVEEWVQMLLRAGPKALAAQKRLMGVWEQVPAQEAIHAGVWEFGRAFEGDGFDSEGRRMMHEFRAKNHGRKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8P5</accession>
    <name>A0A1C1C8P5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBL3-like ubiquitin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8P5"/>
    <dbReference type="STRING" id="86049.A0A1C1C8P5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06231"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07529"/>
    <dbReference type="eggNOG" id="ENOG502S95Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="2">
        <location>
            <begin position="143"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="238" mass="25801" checksum="8D989E44D4E4CE3F" modified="2016-11-02" version="1">MSDLPPNPSPSDHHDVSASPPDNEASGESQVPPMHGPVRMDTNTAMVQSLSPPPPPPPPPAAIAESEQKISRQFSTAIGPSSDDASPTVPAKDGESPSATTGATGPSLTVTLLLTSGARHPFKLDSKYFAKRSVDVPANDPFNLSVYKLKELILREWREEWEAKPSSPTSIRLINMGKLLDDKASLKDYKFSTDSPNVLHMTIKPQDFIEEEDAKGGKSTYSTHREENRSPGCRCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8R2</accession>
    <name>A0A1C1C8R2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ADH2</name>
        <name evidence="8" type="ORF">CLCR_05981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8R2"/>
    <dbReference type="STRING" id="86049.A0A1C1C8R2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05981"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07570"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="20"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="342" mass="36164" checksum="46624E1C30D90ADA" modified="2016-11-02" version="1">MASAPNLPAEYKVGVFEAKGEPIKFKQVKLELPKPGEVLVKVLACGVCHSDHAVRFGLLGNSFPIVPGHEVIGEVAAIPDTEKKWKVDDRVGGPWHGGHDQTCVPCQRGLFQMCENEAINGVTKDGGYGEYVTLRTEAVVRIPSDADPAEYCPLLCAGVTVFNSLRQQKVLAGSTVAVQGLGGLGHLALQYASKAGYRTVAISSSADKKDFATQLGAHDYIDASKGDVGEQLQKLGGASCILFTAPNEKLIPSLLNGLGPLGKLIVLAAAGPVEVNTASMIGKGLSIQAWPSGHALDSEEAISFAQVHGVHCMIEKFPLDKANEAMEKMTSGKVRFRGVLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8Z7</accession>
    <name>A0A1C1C8Z7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">M protein repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_11196</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8Z7"/>
    <dbReference type="STRING" id="86049.A0A1C1C8Z7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11196"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07607"/>
    <dbReference type="eggNOG" id="KOG4673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74178at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="710"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="644"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="306"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="467"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="723"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="825" mass="92196" checksum="23FFCFF5E6117901" modified="2016-11-02" version="1">MAAKPRSGWNFLQQAVASVESRLDDILAEDGERPKRTNTPPHTKKPSSDLSRSNSNASASNDRLQERLARAMAKKNASRTESPVPPQDESSSPISRAADLSTAADDAEAVTNTSHLTGQDAKDKVDDGSQVIPDEEAPQEEETTVLLEKARAVPVSALQSDGDTSRASTDVLRDSRTTSNRPSQDIPRPSVDSQTRQSAAEILEAQAEMNVYLERIDALRRDLQTLVDSVSESARKNADTAKQAAYSAEPGSLEQKISQKDEKIALLIEEGTRWSKTEMELRSTIKKIRAQATASAKEQETSKIRAEKAEQAFRAMEDRAKRAEAANKRVEQNLALSSATTKDLEAVRKERDALNATLTDMKTQLSKANARAEAAENKAQSDQLDKERKRVADLQDDLTSAKVERQISEEKLRQEIRELQAALEREKGQARAMESEMLSEQAALESKLESFRIRAEEASSADTGHTQAKLLRQIETLQNQYAAASQNWQGIETSLLGRITNLEKERDEVVSRDAELRKKSRDTTLKLKNAERELDSLRNKYADMDKSLADANEEVQRLQKKTTQLEKDLAEALKDLETQKQAAERELLRRIDEEKSKWTANLHIPRTESPAASWRKNSGLGFDMGHLMSPVQFERATSRRSSIMHNTFDSNTPPRQQSTTSFRGLANGSTVETPSVVTSMDHDEYFANVPPTPLTTSHHSQRGVVNDLISTSTVGAGPSVQLVERMSANVRRLESEKAASKDELARLTTQRDEARQEVVSLMREAEEKRRIEERLRALEKEHASLSQRHQTTLELLGEKSEQVEELKADILDVKQMYRQLADTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9J2</accession>
    <name>A0A1C1C9J2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_05673</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9J2"/>
    <dbReference type="STRING" id="86049.A0A1C1C9J2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05673"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07852"/>
    <dbReference type="eggNOG" id="KOG0245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000050">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="46"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="476"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="150"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="592" mass="66548" checksum="095F3602B8D36998" modified="2016-11-02" version="1">MVPPARTISHDARPKTPSTASSPSLRSKTPVNVAMAPNNGLNPGGNVKVVVRVRAFLPREIERGAQCLIQMNPHTQSTKLLAPPSTDPANSRAQTRKVVDEKLFTFDNSFWSHNPRDAHYATQEDVYNCLGEEFLDHNFEGYHTCIFAYGQTGSGKSYTMMGTPEQSGLIPRTCEDLFQRIEANESANISYSVRVSYFEVYNEHVRDLFQPRTDPPQYLKIRESPTEGPYVKDLTEIQVKNYAEILKYMRMGDSSRTVASTKMNDTSSRSHAVFTIMLKQIHHDYHTDETTERLARIRLVDLAGSERAKATEATGQRLREGGNINKSLTTLGRVIAALADPKHSRMHSKQRSNRDIVPYRDSILTWLLKDSLGGNSKTAMIACIAPSDYDETLSTLRYADQAKHIRTKAIVNQDHVSSGEKDAQINEMAETIRALRWTLSQQQQNGSASVMKAVQESADAQSEKIREFTTKYENMLQIMEEKLAISESKVRQLEEEKEALSIHLKLVLDELKNPIIINKEESESVGERSRVPTPDMIYEDETASSDEMETDSEADEEAMEMQAEMEALISDLGMFKKKIAADHETFGISVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9Q5</accession>
    <name>A0A1C1C9Q5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative actin cytoskeleton organization protein (Cro1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_05461</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9Q5"/>
    <dbReference type="STRING" id="86049.A0A1C1C9Q5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05461"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07915"/>
    <dbReference type="eggNOG" id="KOG4151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5574718at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024660">
        <property type="entry name" value="UCS_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11701">
        <property type="entry name" value="UNC45-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UNC-45/Cro1/She4 central" evidence="4">
        <location>
            <begin position="241"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT45264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="852" mass="92564" checksum="8B5B817570DCFAF0" modified="2016-11-02" version="1">MSSSIKVAAQRMNRKLSEERDSQRASLLANEAVELFKVGDKVQASRRLREAAALGHANPDVQAAFLTIHNDDQLNSPLLDLVRRYALYHNNPAGDEAVKYLKGPEAANAAAVALECMQILLECRQSTMSDAQDFIVAELARQSPAVREYLAAELQASTTSFFDNVYERGDDAANCLRSIVLDDKLWPTEDVRLRVEDDLFQLFLAKLMETGHDHDGRALKGIALLLIADTQRLHTFVDEEAFEAVMGSLDLRLPADVRGQATLVLSKYFEAAESTGREYLAKYVRSHVERRKGDDLVLAFSGSAHLFPVIPHLVAQLFLTDGFLASTMPLLDRKFSSPIVHDAFLNLLNAACIDGACRAAIARYCASWLSEKVSNGTGKQPSVAATVLAKLRTSGLGVKIGNQRADKADDDVSELVDLFKNSLAVVEEGKTVSDSIEGLAYTSLKSEVKESLAKDRKFLKALLDTLDEHHDSPEVVVGGLSIISNLTQYSPTLSEEQKKISQLKAYANATKPVEPSLLENDEHVRARCSAVVEAGTVASLTRLNRGRSPATAQLSDKILLSLSKNPKDRGKLAQQGAVKLLVLHAQRSLKAEGGSPQNTDAAHALARILISLNPAHIFPGGSTPDITDAIPPLVALLKPPGGEVLSDQARDLLPVFESLLALTNLASAPNPSAASFITKSAWDEVENLLLGNNELIRRAACELICNLTAIPTGAEKFADGTKRAGQRLHILVAMADVEDLATRRAASGALAMLTEQYATVIAAILDLKRAPEILLELCQDEDTGVVHRGLVIVRNMVCCDEEDAQNKNLASRARDAFKKKDEIEKLKNALKKTKEPELFGIGVQALKVLVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAP8</accession>
    <name>A0A1C1CAP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclohexanone 1,2-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_01493</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAP8"/>
    <dbReference type="STRING" id="86049.A0A1C1CAP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01493"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03466"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF5">
        <property type="entry name" value="DUAL-FUNCTIONAL MONOOXYGENASE_METHYLTRANSFERASE PSOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT45556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="567" mass="63756" checksum="64237625CF506E72" modified="2016-11-02" version="1">MAQHHYDALIVGAGFGGIYQLHKLLSLGLSVRVIDVAGDVGGTWYWNRYPGAMSDTESFVYRYSWDTEDLQTYPWSHHYVKQPDVLRYLEHVVEKYGFRQYMQFNTEMVGADWDDEAGVWRVEIGNGDVVVVKYLVTALGLLSRANYPDIPGIEEFRGEMCHTAQWRPELDLANKRVGVIGCGSTGVQVITDIATKVKTLTSFQRHPQYSVPSGDGPVSAEYRAHVNQHYPEIMKQVRNSICGFGFVESTTPFHSVPEEEREHVFEQLWQQGNGFRFMFGGFSDISTDREANEAACAFIRKKIAQIVKDPEKARKLMPRDYYARRPLCDGGYYEQFNRDNVEIVDLTQTAITRITPTGIETDDGTVHDMDVIIFATGFDAIDGNYNRVRIRGRAGETLKQHWEPAGPTSYLGVFVPGFPNLCMITGPQSPFSNIPPAIELHVELIASMIERAEQSRRVGRAAVHDVIEALPEAEEEWIQQCERAAEGSLFKETASWIFGNNVTGKKVALRFYFGGLAKYREAVQRIIDDGYRGFRPLGEQTTASEAAVTANHVPIEVVNVPSGLVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAU6</accession>
    <name>A0A1C1CAU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_01674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01674"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03540"/>
    <dbReference type="eggNOG" id="ENOG502SZ82">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4232400at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="3">
        <location>
            <begin position="48"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="209"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="289" mass="33473" checksum="96DA7B6719013159" modified="2016-11-02" version="1">MSFMLDPRGDLPPPTIQHSSYYYNQTHTRGTSFGLLNKKPKKKQCYDWIFSTASNVHIAIDRTAFKTYAAFKSYVLTVSDQRQVPVRGIGTVELKLRREPGSRDNHTIILERVLHVPDWICNVFSDIYFLPASKYEHTWTEFGVNFFVRDKEILKPWGYTENFCGLDRLVLSKNHQGRNPMLEDPDREVFSVSLTWPQSQKDKWDKRVAEELKLEAERLEKTSKKTQAEEETRVLKRQAKSALVEGTKWRLVPDVSNSERGKYESKSGETSGAPKILPRVSSLFDPVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB03</accession>
    <name>A0A1C1CB03_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative clock controled protein (Ccg-8)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB03"/>
    <dbReference type="STRING" id="86049.A0A1C1CB03"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01553"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03546"/>
    <dbReference type="eggNOG" id="ENOG502RG16">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013927">
        <property type="entry name" value="TF_Opi1_Ccg-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08618">
        <property type="entry name" value="Opi1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="476" mass="52419" checksum="F193CD8B55009E33" modified="2016-11-02" version="1">MDSQSPNPPYAVPPPFSPPLSAHRSSADSQKPASGDIDMMRSDDRSTRAGSVLSGMSIEDMEAAETLNNLSQSKVPAHQQPPTLVQTHTTFHDHQSEPLLRLFTSQYPWTRPLIDGSLSAYKTTQSYIPGAEWTERNVGLPIAGTVARISGAEAGLRWALQPKRDGRLPLKNADVEKGYSDTAPDGTRRPSSEMTYSETLPAYNAGDRSPPYSEQQVLLQRRDDRHPPPGWRQQLVVSTSGLGIAMSEESIRSLKYCLSWLRWANGHLGEAIQNLRNLLERWDEGLTPGEQPPTMSVANMTQTQEERRQAALSARIAALKADVLQTLKHVVGIVSNYAGGALPQNARDLVHRHLTSLPQRFSLANMEGGEGASADTDASEAAKSGRRVMVLAQEGLDMMTQVSRVVNDTLVSAEGWCEKLGRRRNDEQQTPQQHMFAIEKMETGSRDGRSRSETVRSETLAPSESEKENGDIKMTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBE8</accession>
    <name>A0A1C1CBE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01730"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03674"/>
    <dbReference type="OrthoDB" id="4146997at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="177" mass="19717" checksum="B27E04F56925754A" modified="2016-11-02" version="1">MSMAATEDETLFNSTASITEPPRAYFSIPRPDLVLTIIDNPFRTRQSTVLVIIGVVALGICTVFLAVRYAQILRCNMHEHVKAPLTLEAQKSNRLGDDDKNEDYPGDRTPVTQSPDSYDDKHSSIRRRPRARLPQPKTIAIGGVREGKIAQRRASRSRSVGRDMQAPDDTLAMAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBU7</accession>
    <name>A0A1C1CBU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ketosteroid isomerase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00504"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10017"/>
    <dbReference type="eggNOG" id="ENOG502T4WB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4115505at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41252">
        <property type="entry name" value="BLR2505 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41252:SF1">
        <property type="entry name" value="BLR2505 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650693" evidence="1">
        <location>
            <begin position="31"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="85"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="224" mass="24651" checksum="64F3D549E4D33A88" modified="2016-11-02" version="1">MQMPTLVPLRHLATISLVLIGLSCWSSVFSDNHHNSYHPDLGTHLHKHFGAPPRSGLMTRMMAEAHPSPSHKCTDSTTESTRSFVESLFTAVALDNFGASFAAALSDELVWTVTGSSPIAGTYDGKQTYVDRVLTPLRDVLVTLPVPIVEHIFADGDWAVVNWRSEGVYGKNGANYDMQYAWLMRTAVDGDDGERKIVEVTGFYDSVKVTAVFEGYAFNTTKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBV6</accession>
    <name>A0A1C1CBV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBV6"/>
    <dbReference type="STRING" id="86049.A0A1C1CBV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00363"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10059"/>
    <dbReference type="eggNOG" id="KOG0961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000036">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="2">
        <location>
            <begin position="58"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="3">
        <location>
            <begin position="198"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1059" mass="118657" checksum="28CABC0CAEBFE2C1" modified="2016-11-02" version="1">MVSMRASPRFRQLQKIQPDYCPSTITQYESERTGMRVVVVDQEGPKLHGFFVLATEIHDDSGAPHTLEHLCFMGSKSYKYKGFLDKLATRAYSGTNAWTATDHTAYTLETAGWAGFAQILPVYLEHVILPTLTDAGCTTEVHHIDGNGNDAGVVYSEMQGVQNTASELIELQSKRILYPEGVGYRYETGGMMEQLRVLTADRIREFHREMYQPKNLCVAIFGEADHTELLAILDEFETSILSDIPSPDAPFKRPWIESELTPSLKESTLLKVEFPEEDESFGEIDIRFLGPDCADVLAAGALNVVLLYLAGSSAALLDHILVEKEQLASGIYYQVDSRPRIEIQFSMSSVETERLGEVEKRFFEVLKDAMDKPLDMDFMKDCIDRQVRTYKFNAEGSPTAFADYIISDYLYGKRDGSTLEDVKSLKPYTETLANWTEAQWKAYIKKYISDAPHVSILGVPSARLSEKLKTDEANRIEEQKAKLGPDGLKKMQEILDAAKAENDREIPTDLLGKFKVPLTDSIHFVSTSGARAGLAQEIGRRNNKYQRIIDSDSTDVSLFLDFEHIPTNFARVNMIISTETLPDELRPLLSIYMEAFFNLPVKRGDDVIDFQQVVTELERDTVGYSIDSASALGNVEGIRISFQVEIERYDVAIKWLTELLYRSIFDIERSKAINSRLLADVPDAKRSGDDMMINVHQMSHLSPKSIGRARSTLVKALYLKRIKQLLEKEPAQVVQQFERLRSTLCRFENYRVLVITDLEKVHAPVSTWRPFLENLSPTSELTPIGKRIERLSEAGRHPGKLAYVVPMPTIDSSFAYSVARGPTSWDDPQVAAIMVAMAYMNAVEGPLWVAVRGTGLAYGTNMGFDIESGFIHLDVYRSPDAYKAFEASKKIVHDHMSGEVEFDPLMLEGAISSIVVSFANEQQTLASAAGSSFVRSVIKGLPEDHMARILKKVRDVGVQEIKTALKEVVFDMFRPGKADIVVTCATGLKEAIADGLKEAGFSPEIRDLNYFQDDYGLKPIDGEEDDNEEEDEDEGDDSDDIGGSEGYEIVEANEDDLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBX7</accession>
    <name>A0A1C1CBX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synembryn-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_00460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00460"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10043"/>
    <dbReference type="eggNOG" id="KOG4464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT45967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="49398" checksum="F86F26C262A17BE6" modified="2016-11-02" version="1">MPSQTPQNEARALLALLTACLGSKTNEQKQLEEALAKLKILGRDANNVAAIYNADGIKTLGSYACGDFPPSIRHEALRCTANALLLLPETRKYSLEFGFDKQAADAFRDADEDEEFLLSRIMFLLTYDPGIDMVTLVSEHGLAESIIQRLARHADQAKNAKRTGLAAQGNMAMSETLKLLFNATSIKTDQAVKFKPAVAPICRIIEYTDVPSPPLQPPVNLLINALANLDIDGEDTQTAETKSAVARLISILALAVEGHPPTELDTTAVPLLTVLRKINDTAPPDLRDSMKARLLPDDKERDQPLGKSSSLASQLLRLTTSSGMLNLSEAISGLMFELSGQDANEYVKNVGYGYAAGYLMTHKIPIPESAKSQGNGESSNQVPVNPITGQRLDKEPDIELPHMTREEKEREAERLFVLFERLKATGVVNVKNPVEVANDAGRIEELSESDPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC05</accession>
    <name>A0A1C1CC05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC05"/>
    <dbReference type="STRING" id="86049.A0A1C1CC05"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00415"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10014"/>
    <dbReference type="eggNOG" id="ENOG502SANW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5342758at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="193"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="66721" checksum="F55D063E666EC61D" modified="2016-11-02" version="1">MMKKSFIERIFPHAPGSADSLPQFHDDYSDSPPRSAASPPRILMQDSSRASSSPERRRRNASLSPSQHHAKLSSSLVRHDNPFLQVERASKNLERTFQNLLDAQSEGLSAGGTRWEEADDVSSVGSPTPTPSVGTTPLSSGAVPRPKTVPIRQPKPNKITLRGARRGLEKSMREFAALKQHELSLIDQEVVARDNAIRQASGLRDRRQLLEDDIDKIKSAEGPVSLRTQVEAVEREIQQLEATLLELRSKHRVLVNQLREVESSRDSELSSYTASLALNENQVKSFLKRPPVLQSLNAGREPGMYALRPERRTLQMAQEQWSNEVEALARRKASVKVEKSALEEGSKLWRDAMQRIREFEKDLKTHTRELAAQSQSQLHQSSLENEAAQSSTSGDLSMTVVLAKLSALISSLEKDLQHAETTNWNLLICAIGAELAAFEQARNLLQETAGIPSVNSGSIERIGQPTPQDEFRPVDNESHDDEPSPDLLGGQLEDMFERNGTRSPGGSSNHSLEDTLREFGNPRDKGKQGTKDEHVEGLEHGPLSGSGHHRPQQSAQRGVHESDAGLSPAPTAASSNIRPKPPDRRMTSESEDDEPGPEFLLSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC91</accession>
    <name>A0A1C1CC91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">met8</name>
        <name evidence="9" type="ORF">CLCR_01294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC91"/>
    <dbReference type="STRING" id="86049.A0A1C1CC91"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01294"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09376"/>
    <dbReference type="eggNOG" id="ENOG502RYIW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="8">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="7">
        <location>
            <begin position="163"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT46143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="256" mass="28578" checksum="F07201055B622F5A" modified="2016-11-02" version="1">MPPQFPEIQGGGSLILAWQIKGKEVLVVGGGEVAAGRIVNLLNADASVTVVCPRSGLNEEVAYRVEQKQVKHVDRIFLPLDLEPEKNVAMVLTAVDDPEASTRIWQYCKKLKIPANIADVPPECDFYFGSVHRDGPLQIMVSTNGNGPRMAAAIRRQIGDMLPQGTGDSIKKVGQLRRKLRRVAPGKRTRDISKRMAWMSDVCDKWTTENFNAMDEEDMDKLVQYYEAGTVPSFEEIRHGSRGDVVWEFDGSFGWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCA1</accession>
    <name>A0A1C1CCA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_01200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCA1"/>
    <dbReference type="STRING" id="86049.A0A1C1CCA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01200"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09367"/>
    <dbReference type="eggNOG" id="ENOG502QWIS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="439" mass="49029" checksum="E5273B184DA639AF" modified="2016-11-02" version="1">MSENETATRTPAVPSVVLPGIDGGNPGPMMLWNPLTASFFSGERALLLKSSSLLLLQHYLENTATFLVAKPLSSNPFITLVLPLAYSDDLLMHAVLALSGTQLSFKKSGDLSVQSATREHYSLLLRNLGHLFADECAHHDIQRTLRLLLVLVVLCHIEAISGEPNGGIFPHLRASRELVYKLLHEPREDVHPDTRAVEGFALEMYYYLVIVNSITPYGSDEARALPLDAFFTPLDFLKEYQTYGVMLSCGQGLFELIPQVSILARKRLMEEASGLRSSESQATYECLLDSISQWQPPPVISEMTEWQQECAWAGEIYRQALFIFLKASSCGSVVNNPKTIIAIQRHIDTAFPLLVPVSLTPLVTVLLWPLMMIGSCLICESQRREYLKFLDTEPKVEIGQVSQAGKLLQYLWEDGDERAYGSFGLHLIMKKHNINFSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCE8</accession>
    <name>A0A1C1CCE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein TMS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TMS1</name>
        <name evidence="9" type="ORF">CLCR_01192</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCE8"/>
    <dbReference type="STRING" id="86049.A0A1C1CCE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01192"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09379"/>
    <dbReference type="eggNOG" id="KOG2592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650711" evidence="8">
        <location>
            <begin position="18"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT46137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="481" mass="52690" checksum="B02F31726FCA53DF" modified="2016-11-02" version="1">MGGVLAIPALLLPSAATLWSVGASCCGAASCSMLCGPCGMSKFRSSIATRIAYALILLVNSIIAWIMLTPWAIKKLEHLTLDYMTFKCGSSKCYGYFAVQRINFALAIFHLILAILLIGVRSTKDTRAGLQNGFWGPKLLAWIAFVVLSFFIPEGFFLFWGNYVAYLGAMLFVLLGLILLVDLAHTWAELCQDKIDEGDGPNYRIWQVLLMGSSLGMYLAAFAMTIVMYIFFAGSGCSMNISAITINLILLFAITLLSVQPAIQDANPKAGLAQSAMVAVYCTYLTFSAVAMEPDDKHCNPLIRARGARTTTVVLGAIVTMLTIAYTTTRAATQGFAMGNGTKKNSYAQLTQDEYEHGLVSQQPASRREIMRAAVESGALPASALDEDSDEEEETEVSSKDDERQATQYNYTLFHVIFLMATCWVATLLTQKMDPESSTDFTPVGRTYWASWIKIISAWVCYAIYSWTLVAPAVLEGRDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDF6</accession>
    <name>A0A1C1CDF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">30 kDa heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hsp30</name>
        <name evidence="6" type="ORF">CLCR_02105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDF6"/>
    <dbReference type="STRING" id="86049.A0A1C1CDF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02105"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01292"/>
    <dbReference type="eggNOG" id="KOG0710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="42"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="224" mass="24954" checksum="3D393A635BA6D8AB" modified="2016-11-02" version="1">MSFLFPRIAFAPVRCGPVRHEAAPLFSLFDDTFNELQRASQAARKQFNPRFDLKETKEAYSLEGELPGIDQKDLNIEFTDEHTLVIKGRTERQSESGRRPQAVEAEQKAAIEGTSANSESGSVKSHRPTVEDEEPANSSAATENETEVASSTPTSAEQQVGKTEEQQPEQQYWITERHVGEFTRSFSFPHRVNQEAVKASLKNGILSIVVPKAPAPESRRIAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDN8</accession>
    <name>A0A1C1CDN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actin-related protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ARP2</name>
        <name evidence="8" type="ORF">CLCR_01965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDN8"/>
    <dbReference type="STRING" id="86049.A0A1C1CDN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01965"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01380"/>
    <dbReference type="eggNOG" id="KOG0677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT46655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="391" mass="43914" checksum="0A930E850EB2EF37" modified="2016-11-02" version="1">MAEPPIGTVVLDGGTGFLKVGYAAQNFPEHQFPSIVGRPILRSEEKAGDIVVKDIMCGDEAAAARSMLQISYPMENGIVKKWDDMQHLWDFTFFEKLKIDPTGRKILLTEPPMNPLKNREQMCEVMFERYGFGGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIVPVYESTVLNHLTRRLDVAGRDVTRNLIALLLRRGYALNRTADFETVRQIKEKLCYVSYDLALDQRLSEDTTVLVESYTLPDGRVIRVGSERFEAPECLFQPHLVDVEQPGIAEFLFNTIQSADVDVRSSLYKAIVLSGGSSMYPGLPSRLEKELKQLWLTRVLGGNPERLSKFKVRIEDPPRRRHMVFLGGAVLANIMADKENMWVSRQEWAEQGPRVLEKLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDV7</accession>
    <name>A0A1C1CDV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDV7"/>
    <dbReference type="STRING" id="86049.A0A1C1CDV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01929"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01434"/>
    <dbReference type="OrthoDB" id="4158777at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="58798" checksum="51C0707BD479ADEE" modified="2016-11-02" version="1">MSSSSPVYEDYNPLGSQDRPERENSSEDHARKRRRIEAENTHASNMTDPSRPPPNSRRPVFPAHYDFLGPTLHAIPHGMPLGLPIGTFLEEDAALEYLTSGSGFAQDLRDINLSQPPPPPFYVAPNLASRSAALTSHPSQSSMPQQPGLVSFNDFFVQPTAPTIPERRRHVEGNATAPSGNMTAAPTPFDFSGHPPYRPPSYPPHIPVIEGISPPRRTAPISTPATGEVTKKPATMLILSRASEDSIKALDEHKRDCPTCCLQFEPNNFVAVITCCNMAIHARCLSAYVNSQGYSKSRVCMKCRRGIDAKYMLNKVMPPVTDKDWDEGGDFNAPESLQAETKIELNVTARPHRAGSHRHRISMGYSGHRAGRHTYLPLEHLTAEQRLAVLHLREDHLVELEELRNRCNIAMENSGRLNHQDLDANRALVDAQTRATQQELSALLKRCQETRLARDKAREAYERARMELEALHRAQSRRVTEMIEEYQAERERELEARSRDGEAPRSAPIAIPQLRVVNGDPPSSVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEN4</accession>
    <name>A0A1C1CEN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-histone chromosomal protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_02646</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NHP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEN4"/>
    <dbReference type="STRING" id="86049.A0A1C1CEN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02646"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02460"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="54"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="54"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT46959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="148" mass="16313" checksum="E248FDC733A9AFB9" modified="2016-11-02" version="1">MAKTSAAQTTTKSKSTSKVTKSSSTRTMPKASAKSSSKAKGRGTEKKKKDPNAPKRGLSAYMFFANEQRETVREENPGISFGQVGKVLGDKWKALSDKQREPYEKKAATDKKRYEDEKAKYNVSPGQTLSPQTHSDTEQAADDDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CES2</accession>
    <name>A0A1C1CES2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CES2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02628"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="180" mass="19401" checksum="2BE8E3999B0B6256" modified="2016-11-02" version="1">MEYKRPSAAGLDGHLDKEPAEALASVSKRGVLGCWVAIITTVGAEVLVHPVEKLETTSPAASKKRETYPDLSLLTLTIQGRLAITHSGDTRNKALPRLLLLGFGEQEAGVVSSGRNVPQSIHHFCWIAHGQADGFWVMNAGKANVLLSLFLMDECHSPGAAAPCSKEILQDYVLKCHVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CET1</accession>
    <name>A0A1C1CET1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CET1"/>
    <dbReference type="STRING" id="86049.A0A1C1CET1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02226"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02409"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08257"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="482"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="518"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="652"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="687"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="722"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="757"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="794"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="828"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="863"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="898"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="933"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="968"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1075"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1110"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1145"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1239" mass="131210" checksum="B28AB826932C0A4D" modified="2016-11-02" version="1">MPKAKFTVCGAGKALNNTWIYASSVEAALRMSNASLMHQRLAYTTAGAAHNSASANKIGYTILLSQYTRKFRKWGFSKYTRDDSWKFISYRIQKRQLLGKDSVVFIHGRKQAAEKVRKEIARHVPLLQTYQQASAGDPATPKDVSVCTPAALTEFQLHQPRRLPSFEFEDLVERQICARFQSTPFEQVSNQEYLSFAPMSFTSDDFDWWDTTFRLPLHANTLSADNTWLHAPFDMQSSANHHPSALLAGDPSLHQPFPAVSGAPTEESVCEARLLLARCLEGVEARSSAAEIDHIYLRLEPFMVDRDNGGLAASVKSLYNSQPQVALSRLFVFCAYLSSNNLMSDTETAKLVEWISNNGQAWVIKHIRKSSSLSADIFASNLLVNATELGDISIVKCLIDVGVDVNAPGGATYWGTVLSLAAESRNLQLAEILLAAGADPNIVAAGTFQMTPIQAAVSAGSVAMVKMLLEAGADPNGQPQLVKLSPLIMAAHSGSTEMVEILLQVHADPNMISESADGYVTALQVAAANGSPEMVHLLVDAGADVDAPWGEAYEEVLTRCKHFALPMTMTPLQLVAEADDLVSVQILLAAGAGVDLSPANSCRYSACAFLEGDAEITLVSPLQGAIWNDNTLMVRMLLCAGANLEFRAMGGYGHTALQVAVATQNESVVRRLLQKGANVNAGAARYYGRTALQFAADRGNLELTEILMDAGADVNALPAIDGGRTALQAAAEVGSLEVVQALIKAGAFVNARASSTEGLTALQAAASAERNRMEIVKLLLKAGADPNAPAADEHGYTAVQAAVRSDDIGVVKLLLDAGADVNASADGYGQTALQSAIHNRHGDIARLLLKHGADANDEANHSCRLTPLQIAAKDGNPELTQLLIHANANINAPAYFHWGQTALQAATGSGSSALVQLLLDSGADVNAPAAEKGGRTALQVAVENYNLHLVQLLLKHGADPNAPPASVNGTTALETAVRTYFPQPQILQTLLNAGADPNTPFAKGWTALQLACRQGSLRVVQMLLAANADVNAPANAEIEGTRSAIQAAATTRNIDLIETLITAGAWVNSPANPEDGMTALQIAASTKCTSVVQALIREGADLNAPASANRGRTALQHAAEVGDTKLVQQLLNLGADVNAPAAKIAGVTALQAAGIHGYARIALILLQAGANVAAPGAMSQGRSAIEGAAEHGRLDTLVLLLDAHENDEALESERKSAAKLAADNGRLAIARFLHAYKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEX2</accession>
    <name>A0A1C1CEX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEX2"/>
    <dbReference type="STRING" id="86049.A0A1C1CEX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02650"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02413"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="179" mass="21060" checksum="DF3D8674CD8AF447" modified="2016-11-02" version="1">MADDEREAASSSFNKTDTDRKERESSRGEDRRRSASPRRDRDRREDRPRRKDAGFKWKEKRKDDDDSSRRARDSGLQRGYRDHYRPRSRSRSPPPRRHAPTRDDSDRERRRDRGEGEPREEREEKRPKKEKKPAPSPAAPTQPMIIVYVNDRLGTKKAIPCFPTDPISKSNDPVLSSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF27</accession>
    <name>A0A1C1CF27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_02272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF27"/>
    <dbReference type="STRING" id="86049.A0A1C1CF27"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02272"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02338"/>
    <dbReference type="OrthoDB" id="4134574at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="535"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="569"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="668"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="735"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="767"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="768"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="797"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT47082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="818" mass="91404" checksum="EFAF5D5FB9AE0552" modified="2016-11-02" version="1">MAEAFQVAASAASIANFAFKLYQTLSAFVVKARDAQCSAKQLVDRAQRLRETLLMVRVTMSNRGRHFDDEQASEAEQYICNRINQGLRAFSRTLTLFRREIKKLNVGERESWLGKTVWQLRRDSADPRLTALQSDIAAFTAELSLSLQCMNLADVSGRQSSIEEKLRALDRKLEDCRHSVDAARSLDVSGTTGGSTSCNIHTQRAIHSIAAAEAARNSVVNGGEPSRELARLSRIITAREDEHSSPGIEALVDTGEDEEEIQETSEHGDPATTRADVVEADPDPSFDDTTPREPLEELIKSYQESVQQGRVAGDDDLEKVEEFQRRLIEHATEFNQTYEPTHDVERMWLDLSHILSARARLEEAHDILNTRFPSNPQGRVRLTTDALLQTESEPRTPTDAHTRLLQSDFYYALADLQLQQYEATQDSVFLHAATKWAKRCYRLRLELRDTGIREFRESVRLLVLVLKLQQLPVAVDVYTRLYLQGAATASPPTPPPTPVAEPPALAPARAVKRGDVEKVDLYHRHGADLEVRDKAGKNALIHAVENDEHPHLVVTKLLERGADVESTYKGLTALHYAIYLDKPTVVRLLLSKGAKIKSTIQAGETTSTEPGELDLKGKTTLIYAVLRMNAPPTPEVRRSVSSLEGHNAIISTLCERLQQEQKDAPDSDNLTALHHAVHTKSIEAVKTLLDQDVNPNVKDRQGKTPLHYAAERKLKNIVKLILNASTTEINLTNNAGRTPLFVAARWNEFEIVELLLARGAGFDSNASLDRRLRPPDINRNTEKLLESTKTTRHGRADSISTASSSRSRRSLSWTNRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFD8</accession>
    <name>A0A1C1CFD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_02500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFD8"/>
    <dbReference type="STRING" id="86049.A0A1C1CFD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02500"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02263"/>
    <dbReference type="eggNOG" id="KOG2970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016477874" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="28"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="330" mass="38184" checksum="BCFC1A33D5BE5C57" modified="2016-11-02" version="1">MRRLGAGVFRHIPLILVILALLNSSLASLGDRLPDFRECVKVCVEENCDSGQAALPLHLRILLWDCPSECDYTCQHVITDQRKARDPPMIEPVVQFHGKWPFYRFMGIQEPFSVLFSLMNLLAHREGMQRIRESIPARYALRPYYLALGYFGLASWIFSMIFHTRDFNVTEKLDYFAAGASVLYGLYLSPIRIFRLDKNDSTKQSILRVWTILCVSLYVAHVTYLTAWSWDYTYNMAANVVVGVLQNLLWTWFSISRYRKLKKTWAAWPGLIVAWIVMAMSLELFDFPPIGGMIDAHSLWHLGTVIPTIWWYSFLIKDAQEDLASERLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGH7</accession>
    <name>A0A1C1CGH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03724"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10147"/>
    <dbReference type="OrthoDB" id="4138157at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="131" mass="14475" checksum="346A103872B5FC9D" modified="2016-11-02" version="1">MAAYHWIEPQHVHDAAALRTGRRALTPPFVLPPAGLSWVDGTALQESYQKGVVGTLFPGASGVWHTIGTHLARQVYVVKDLGEMDARETSVQHVNADEVKFGEDVMRLGARETPDSEEYLYMRPAYPPTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHN8</accession>
    <name>A0A1C1CHN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHN8"/>
    <dbReference type="STRING" id="86049.A0A1C1CHN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04475"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08205"/>
    <dbReference type="eggNOG" id="ENOG502SBS6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="75" mass="8556" checksum="3A9EA188AB337F55" modified="2016-11-02" version="1">MPTPESEGFLRQKPKVPPTFEGVDFQDNEAVADARDAIIREQWVQKMMRRLVGEEMGMCAALFYAVCGEVSWEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIA5</accession>
    <name>A0A1C1CIA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger RING-type eukaryotic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_04115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIA5"/>
    <dbReference type="STRING" id="86049.A0A1C1CIA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04115"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08402"/>
    <dbReference type="OrthoDB" id="116827at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger RING-type eukaryotic" evidence="5">
        <location>
            <begin position="275"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT48255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="450" mass="48863" checksum="AD03DA7E7D70DBF7" modified="2016-11-02" version="1">MSHSKRNTSLAYFTSHERSLLRSTWGTQSTRLTRESFLPFGFCRLCLSYARDPVCCSGVGGGSSGGGSETKSTTEKDRSNPRPQVHLFCRECALNDMISQRREIRRLERETQLREREAVEAQAMEAEQRQQRELERFERNELGFEDEGVAKKNKRKREAHDADNDDGADDDDEQRGNASRTQDKAKGSNFWIPSVATSTAATNSNSNSKASLKTSKPKKVHPVCPASTPHMQHTYSLKSLISVSFSLSDSGARGTRTGGEGSPADQDHDHPSRICPSCKKVLTNTSRPVLGTAEQCGHVICGGCADLLFQTRQGADSAVDDRKPTPTPRTIIRCFVCDADLSGMDDGGGGGGGGGGGGGGEEEGDGEDEDTTDGKHRHGHKNAKLNHHTHTDIAKEKEKEQDDAKVKTKNKPKTRPHRQGRLVEISCEGTGFAAGGGSSMARREGVAFQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIH4</accession>
    <name>A0A1C1CIH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pon2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04092"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08463"/>
    <dbReference type="eggNOG" id="ENOG502QUCT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF12">
        <property type="entry name" value="PARAOXONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650824" evidence="1">
        <location>
            <begin position="20"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="394" mass="43274" checksum="478790234C315382" modified="2016-11-02" version="1">MSTRSVLTFLLPLIPLVLFNQSAQLWRLAGRVEIDKTRLVRWENSSPLNNGDCRVIDTANACEDVKIHSPSKTAFLACGDPVERTHWYPPSGVRTVSLRAESSFREQLFKHDLVTGETTQLQLKGLDGDFVTHGIDILTLPEDPSQIFIFAVNHARNGDSIAIFSHELGSDVVELVKNVKHPNIKTANGVAATGPLEFFVTNDHYLAGGPLRVAEERYGPWTWATNVQHCNAAAENVICRQVSGTFPGANGINLWEDRLFVGDSKNGTVTIFQIHTDRTLTLLQVVDLGAAADNINFLPTTGDPIVAVFPTLEDLPKYLENVRSLGRDLLVPAAALRLRKDKNYAPELVYFDDGSKISFMTAAAVDPFENVFVGASVLQFGGFAVCKVAAETWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIK0</accession>
    <name>A0A1C1CIK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIK0"/>
    <dbReference type="STRING" id="86049.A0A1C1CIK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03942"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08427"/>
    <dbReference type="eggNOG" id="KOG3986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="342"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="672" mass="73149" checksum="D99DE6237C774FE5" modified="2016-11-02" version="1">MPYTPPAQLSPASSKNPSPTPSRSHSYIKGQQLLSPELPASAGRPDLPRSQGSSSYISKHRRSPSLNDAQNGEILHNGEAYEENGAFDPHGSIRQSPPPVTNSAMPAQMTISPPESSHNSSDEDEPERGRTRDLEVENLQALHAAIRSIDLRKSTGSPTRGGDLPSTKLDVPVSRLDGTHSAGPQLQRPPLSQEARKISHSRSSTDSSIVFEPPQKQTPSVVMPSESDDSDTDNGPGERPPMLRKKSGELVRPALRPSSRRRPSSMPGTPTYSKAVHFDSHLEHVRHFLQVDRPLAVSAGSSPVENYESEGEFPFGSDEASSRPRSSAYEWEISLANFPQDSETRRSQPVFVDRVFLSADNKHLVGNIAVQNLAFQKSVVVRFTLDYWKTTSEIVADYNNDVRRKGPHDNLDHFNFSIKLADQANLETKTLFFCVRYTVNGQEFWDNNGGYNYQVDFSKKGKAPQAKKPAAAPGLGERPLNALPRSRPSSATSSGRPVSMPTSFDDFSTGFDNFGSFGQSAGTLMGEPKLKLRSPRSKAELIPDAPQRRKQAGPQAFGHRYDFNSSLTAAKNNAYAALGDWSGLNLRATAKQSSHDVPATIPVAQSVVDAAPKHENGVNGIKTGASNATFLTSKPAALVSEKPSLTSQSYQELVDKYCFVGAQGKSEEVTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIT2</accession>
    <name>A0A1C1CIT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lactose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LAC12</name>
        <name evidence="10" type="ORF">CLCR_03958</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03958"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08562"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF79">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="72"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT48434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="540" mass="59714" checksum="C18B12ED57F0598A" modified="2016-11-02" version="1">MLVEKSGLEKEIGVTQLETADSNVHNEIEEIQAFGKTAKVVQTQDSRFAAVIARHKDAASPWSKSLLRLYPILFVAFMNSAANGFDGNTFGGVSSVREFQKRFGTNVAANNGFLAALYILGNVLGSFVAGPLADILGRRRGMFIANIVVMIGSAVQAAAMRRRDMIAGRIVLGVGSVMLGPSAQSYTVEISHPAYRGVMMGLYNGCYFIGAIVSTWLEYGIVNDTKGELNWRLPMAVQAAPCIIVLACIFFCPESPRWLMSRGREEEAHAILTKYHGEGDPNHEIVQLEMDEMRDRVNTSGSDKRWYDYRELFNSRGARHRMFLVLCVGFFGQIDLPPTSYYMPLMAQNAGVTSEKQRLLMNALQSPIMTIGTLLGVRFIDIAGRRPMLMGSSSVCSFCVLMLVICSALQNHHHALGLVGISFVYVFLFAFAFVWTPCQALYPAEVLAYNARAKGLAMSGLWLNIVSFINTYAAPVGMTNGGWKFYILYLCVDVLGIVFIYLFFVETKGRSLEEIDDIFADPHPVKASLRKQKVVVAVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIW9</accession>
    <name>A0A1C1CIW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04255"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08583"/>
    <dbReference type="OrthoDB" id="4142835at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="320" mass="36530" checksum="7D66C1343376ED69" modified="2016-11-02" version="1">MCVRTKTSYGCGCEYKTDAECHSSRCQGLERYHYPKSGDCKACKEAGEALTRGRDGKGRYGQEIGRRALSRQEDVDPPFDPVPEVAEAGNGISPWAPPLAREKEWVSHSRKKADDSWLEEHAERNLDLQSIRESLPSYPPSERDPAPAGRSPHRRPARIYVHEDDLPDDREYSRHHRRYRREETGRSLPVEIRSWSAEDDRPSHDRLYRRRRQDSQESFDSMPSSRSSTRKYKPAPSSYVAHEHVEIHDSGYGSYGSRASDSYGRAKTEPFHYTSSPAPRYMGIEPPSPQPYGGYHTGYGVTPVNVVTRAPSYGYSSRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIX5</accession>
    <name>A0A1C1CIX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04436"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08597"/>
    <dbReference type="OrthoDB" id="4118334at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="123" mass="13519" checksum="8D3EFA855E87C991" modified="2016-11-02" version="1">MVNHLWSRTLRSSSRPLASSTSISTSTLLRQPALPRRSFHPEPRSFPNSAHGTHRFVYRWIIQAIGTPFAVAYLCDQVSERSDGGGGGGGENSFKLALPGIDTGILTEPVRVKSWTWGQVRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ80</accession>
    <name>A0A1C1CJ80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyoxylate/hydroxypyruvate reductase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ghrB</name>
        <name evidence="4" type="ORF">CLCR_04245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ80"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ80"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04245"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10279"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="100"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="331" mass="35773" checksum="60935CFDAF7F74B7" modified="2016-11-02" version="1">MKLLYPNSLVFDPSSLEGFGVSLHQYDVHKPIPEELIDAEIIVTWANTNLADAAKRMRNLRWIQSLFAGPNDVLAAGFSPDIKVTAGTNLHDETVTEHALALLLSAARKLYEMRDYQNQGKWPGHLGGFLPDRPKGSFTSLKGANILMWGMGNIGRKLAPHLIALGANVRGVGLFEEIIDGIQVQTNDALPKLLPQTDALIMILPGSKATFHALNAERMKLLPNHAWVINVGRGTCVDEDALAQALHARTLGGAALDVFHTEPLPASSPLWKAPNLILSPHAAGGKPRYSEALVAENLRRFLAGQPLKHDVSAGGMYAAPPENKPALKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJP0</accession>
    <name>A0A1C1CJP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05191"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03161"/>
    <dbReference type="OrthoDB" id="4134702at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="190" mass="22035" checksum="39148C16E5D0CF47" modified="2016-11-02" version="1">MDGHSWTESRTRSPSVVPDEGIRGFLEEKTANLFATQLQSRLTTLEQTKETPKFLRRNSYALYLEGHFALLDPRELQRTSLSPTPPSSDDDWTSVERTPEPHFKASTSKVCLDESLYPRLKTQQGQIERKRQRRQDKISHRMAHKHSHRMLRRSKNKSNALFYELDWIGRNAVAVCQMTPDHSQSSNKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKC7</accession>
    <name>A0A1C1CKC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpc25</name>
        <name evidence="10" type="ORF">CLCR_05042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKC7"/>
    <dbReference type="STRING" id="86049.A0A1C1CKC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05042"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02960"/>
    <dbReference type="eggNOG" id="KOG3297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000221">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004519">
        <property type="entry name" value="RNAP_E/RPC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00448">
        <property type="entry name" value="rpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="9">
        <location>
            <begin position="85"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT48947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="205" mass="23379" checksum="A13E1E84A63E3F48" modified="2016-11-02" version="1">MFILTTFEDLVQIPPHGLVKNKITRQDLEDRINEKYSNKVVQKVGLCICMYDLVKASDGLIGHGTGNVNVNVQFRMIVFRPFKNEIVTGRITKCTAEGIRVSVRFFDDIFVPSTMLFDGCNYDANEQTWIWHTEGENEDEEANDLFLDVGDTVNFRIESESWHDQAPAAPKIRRPGESESVTDYKPPYSIEASMTEQGLGGVHWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL02</accession>
    <name>A0A1C1CL02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative xanthine/uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_04672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL02"/>
    <dbReference type="STRING" id="86049.A0A1C1CL02"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04672"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02762"/>
    <dbReference type="eggNOG" id="ENOG502QQ5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="555"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT49167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="598" mass="64066" checksum="9BFF124B5846C008" modified="2016-11-02" version="1">MGINEMIHNANMAVARSFVGRRFRLDGSGHPKERKGSYFFTEIRAGLATFFAMAYIISVNATIVSQSGGTCVCPPDSPDLCDSDPDYMICVAGVQRDLVTATAAISALTTFCMGLSANMPIALAPGMGLNAYFAYTVVGYHGSGLVPYEVAVTAVFVEGFVFVGLTIFGLRQWLARAIPASIKLATGVGIGLYLTLIGLTYSAGIGAVTGAQATPLELAGCKPEFLDETGVCPSAYKMRNPTMWIGIFCGGLFTVLLMLFRVKGAIIFGILLVSIISWPRGTEGANQKPVTYFPYTDLGDSMFDFFKKVVTFHPIEKILVVQEWDISGYGGQFGLAFITFLYVDILDCTGTLYSMARFCGAIDEKTQDFEGSAVAYLVDAFGISIGALFGTPPVTAYIESGAGISEGGATGLTAITTGLCFFISIFFAPIFASIPPYATGCVLIIVGSLMAKAAADINWRYIGDAVPAFLTIAIMPFTYSIAYGLIAGIISYIVLNTVVWIVEKISGNRIRPADKEYKDPWTYKIEGGLLPPWLVRAAKGKKDFWKPYEDLEHNSDSHPAGMTLEGKEEHAMAGGKGSMGENIRSGSSSEEGGEKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM95</accession>
    <name>A0A1C1CM95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urea transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_07254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM95"/>
    <dbReference type="STRING" id="86049.A0A1C1CM95"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07254"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09875"/>
    <dbReference type="eggNOG" id="ENOG502QU2F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050277">
        <property type="entry name" value="Sodium:Solute_Symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086:SF10">
        <property type="entry name" value="AGR155CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086">
        <property type="entry name" value="SODIUM/PROLINE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="406" mass="43221" checksum="1DBCE0BCF852F700" modified="2016-11-02" version="1">MVAELSALQQIINALTGLNGLPAVIVECAVTTIYTSLGGFRVSFVTDNVQGAMVVGLIIIACITVGVETEISHDLIEKSHYLDASLLGWQLMYILPVAILTNDFFISGFWLRTFAAKTDRDLWIGVSIATVAVAIILTLVGVSGLLAGWSGALGDPPEQSSIAFFLLLEQLPAWVVGIVLVMTIALSTAAFDSFQSAMVSTGSNDIFRNKLNLWVLRGAVVLIIVPVVVVALKSPSVLQIYLISDLISASSIPVLVIGLSDRCYAWRGFEVVVGGLGGIFTVFLFGLVFYHGDATQAGNLLLLEQGLYANDWSAFGAFVAAPVGGLLWAGGAFALRLSVQWCIAKVRGTRFDALDKPAAPTAAFYTGGAAVAGGRRDSLGRESEREVYSDEHGVVRSHVEVKGKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMQ3</accession>
    <name>A0A1C1CMQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMQ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CMQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07379"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08711"/>
    <dbReference type="eggNOG" id="ENOG502SQ3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3254104at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="345" mass="38709" checksum="2203C44C9178B0A4" modified="2016-11-02" version="1">MPRNYQRMRETLFDLYTERDALPWYFRTLAIAASCLALGGYILFALVFTSARDNIKVSRAFLTVLASALLVVGYAASAVIAYFSRSLLFLFDAVLLPILTSSFMGVFVTVMNHALHKSFPIPTQIYIYVPLVIACATTLGAGGLSYVIYRKLNKIKELDRQRRQHVQRWERGSYGNYGDATSTTELLPTSAWTANNLPEDEAQRRQLLRLLLNREASQQSPNDHRNSQSTYHINWPADGDDSPGYDGLQVVQPGMRPRSGSLPANPNRWSVLSKITRDRSPTVESQSFKNPRERRREEIERSSILLTPTPGVEHGGWPQTPGSSKSPSYFPSSQPARATGSTRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN99</accession>
    <name>A0A1C1CN99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_06906</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN99"/>
    <dbReference type="STRING" id="86049.A0A1C1CN99"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06906"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08839"/>
    <dbReference type="OrthoDB" id="4119926at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT49921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="478" mass="53306" checksum="720056346D612272" modified="2016-11-02" version="1">MQEKSNVAIKVINPNANDRELRILQHLRTSSVAQDNLTHPGRNAVVHLLDDFDLGKSHKGLVLDVMGADVQSRADAQPGLRLSRTTATGVAQQVTLGLDYLWKCGVAHGDLYSRNVLFAAPEIAALPEEQIMSRLGRPRTGPVCRRDGQGLEPSVPSYLVSPKSIRGSDSEIKIMDLGNAFFHNSPPRLLATPWHVRAPEAVYSQRLSKYVDMWSMGCLLFEIITGRTFMDAFLADRNGMMTGLNAVLGSPPTQWLGDPDTETRELVTQARTRDMALDRYLQLNYDQDDDQLLDCEDEDEIPVEEYEKPKREFTDEELRALSRVLSRLLSYDPTSRGTPQELQNALQCIRKLAVQDLTSMTPIRLFSSIPLLVLFQHISIRARSPLMAEAVGILASTVTVAGLFKACREAFESFKAARSQQLDFREAVVKLNIGKCRLYIGPQAQPRALDTFGSRGLVITTLEALLKLFSGTDQLRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPM9</accession>
    <name>A0A1C1CPM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_07726</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPM9"/>
    <dbReference type="STRING" id="86049.A0A1C1CPM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07726"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05555"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="8">
        <location>
            <begin position="9"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="127" mass="14199" checksum="E2DC27299B48BE17" modified="2016-11-02" version="1">MAVDDDDDDSALLRKMMGFTTFKTTQNTKVPGNQIYGVRKEKKTEYRQYMNREASLDQRGKPVACKTRTGDLSVLGRCLQVAAECKVTKITERLATGAKCGDIQDGLETGRDFYYNPAQHGAQLKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPN4</accession>
    <name>A0A1C1CPN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPN4"/>
    <dbReference type="STRING" id="86049.A0A1C1CPN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06759"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05546"/>
    <dbReference type="OrthoDB" id="3522351at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="686" mass="74373" checksum="591546C89F9771BA" modified="2016-11-02" version="1">MSSAQIPTVNQATANPSSASVSSTSTFSTTTPPSSQATGSTTTSPAISGQQQPPIHLATPVTSQSTTVATSTSNHIPPQTTLPLGSQSQASKDTFIRLFRRFYSKSKPKEWTPFWLTPHGLLGFLLFDLSLIGGIIAVKIGSHSKHGLADVSNSSDSDTVLNYPVGQSLWWTFFPVLIFQIFGLYFAAIIDSRGERQPFVELRGAHGSDTKHSILLDYRSMVAAVRPGAALRNKHWMLSVSFLAALLVSLFLSSLASHLLIADVVPIVDATLTHLSSTFDPYDFGYDSELTPVLDGVSSTLVYGGLFPAWTTSNMSFQSFDRPAMSLKPSTLATYLTNTTAYSARLQCRNLAEGEYVFTQPDDGNGWTFGARDHGCDFSPTAIILTTGFKNYVQTFSNVSCSLDAGLSRLFVLAAHTPDPDTVKPSEVTVLACRTAYFRHSGTLNVTYTVGGSSAVINSFQEHEHGLQPLDNPMPVYYQNFERQLHQPSIFDNTATTSATDFGRLILAHARKQAPQSPFSPRAMLNATSVLFTAAHAVMVSSFLWQAGAADTAGNTVQGSLTIPTVRLVVVDPIANVLLSVLAVLAVLTIWISIDVINNETSLFEEPKGLLGSAILLHESDVNAFASDLRRDVEAAQDGRVLAHAREPRRLWGRALPLSVYRDDVLKKKWKVENWHAPSNTKIVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQB6</accession>
    <name>A0A1C1CQB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">UBC35</name>
        <name evidence="9" type="ORF">CLCR_07625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQB6"/>
    <dbReference type="STRING" id="86049.A0A1C1CQB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07625"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05352"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000020">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="149" mass="16865" checksum="63378B8B818C9273" modified="2016-11-02" version="1">MALPKRIIKETERLMAEPVPGISAVPHEDNLRYFDVSIHGPSQSPYEGGIFKLELFLPDDYPMTPPKIRFLTKIYHPNIDKLGRICLDVLKSNWSPALQIRTILLSIQALLGAPNPDDPLANDVAQRWKEDQEAAIQTAREWTRTHATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR75</accession>
    <name>A0A1C1CR75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR75"/>
    <dbReference type="STRING" id="86049.A0A1C1CR75"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09003"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09634"/>
    <dbReference type="eggNOG" id="ENOG502RT4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28756" checksum="E2EDA4773657452C" modified="2016-11-02" version="1">MSIDVRTTSSPDQKWLDSFISLLSRAYLTTPLTTAFITEIDGTDPSADRSQVITPDRLAKHFTLGITAAAKSNVVLFEGGNFAAAALFEPPDFCGIPPSQARRNPGPILQEWRSAARRLKAKYLSIPDSGEHSYDQPAAPSQSSGAPSEDPYPADFNKDVDVETRPFYHLAMIARDPDAPAETSMAAFKACMDYFLAKAKQEGVPVWLETAAESAKDEYEKLGFRVCEEVVIGKGRVNAQGWPQQGGEGVRTWAMIWDEHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRH6</accession>
    <name>A0A1C1CRH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRH6"/>
    <dbReference type="STRING" id="86049.A0A1C1CRH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08440"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09709"/>
    <dbReference type="eggNOG" id="ENOG502SH5D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="417" mass="47263" checksum="6AD32F16537121A9" modified="2016-11-02" version="1">MSLLHDGSRYGAFKDLLEGARAPFMDTNEVKMEILDIIQTGTGQLMPLRGYTTASELAKESRPNLRLIFAPLDYPTPASSKTLTALFQMFSVPTAFLSERVQSVTHAFGFEGSKDGAFCTWLHFLCKAIEVKHDNIVWLRSGYFLTRDAQSRTTLICFGASALLEKRFNSLPPENWKDAVDDPFRLLTVVLSDLHFQLDEQLWALNTPVGAVEEHTIASSEARDFKLNFVHLHYIAKNLIHLKEASDAILRTVQHMIEEQTENTSSRSVGCGRTLSALRYQQTLFESINLRAVSMEKRMQNVINLSFNLVAQKDSSTILAESSSMHTIALTTLIFLPISTVATIFGSQFFNFIDSDDRDAFHVAPQFWIFWAVTVPLTIVVLTIWIYFHPSNVSRWPLLKRSNQRDQAYRMLDLPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRN7</accession>
    <name>A0A1C1CRN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09154"/>
    <dbReference type="OrthoDB" id="10632927at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="193" mass="20604" checksum="9F834B90A54FBFEA" modified="2016-11-02" version="1">MEEEPSAPSQQTSTEQHRQLPATERHIGRQDPAEVDQHDWQPSGAVGLNVHDTSPALIEEEEEGHFATNALVEQRSTATTPQDTDDRSEDNREERDMSYPGDYHYSRMASAQSERERTSSSTHRGPDTSRSSTSSGSSSNASTPCQGTEPARDTKKDDRSGSGGGGSGGAGASSSSSSGGSRSRLVAGVFVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS25</accession>
    <name>A0A1C1CS25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein atg6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atg6</name>
        <name evidence="6" type="ORF">CLCR_08437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS25"/>
    <dbReference type="STRING" id="86049.A0A1C1CS25"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08437"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06783"/>
    <dbReference type="eggNOG" id="KOG2751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.40:FF:000005">
        <property type="entry name" value="Autophagy protein Apg6, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="5">
        <location>
            <begin position="163"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="4">
        <location>
            <begin position="288"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT51302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="520" mass="58469" checksum="35D9A22D99D19AF3" modified="2016-11-02" version="1">MAEYCQNCRQPIDVDPSLALLNPASFDLLVGTAGKSHSNSATTTISRLNYPQERKDLYDRVSAQPNSPVHKRSIPAPQDGTRLRSGGYSKGNADMSFIEITQSQVALTDRDHREQAKRKAKDQRNGIAEGHEDHKEDDLMSTKKNQVEDLFAILSSHSDIDHPMCQECTSIMLTHYATRLGSANRERDAYAGFLKSTQQTVFPEGQKQSDAKKTGTSLYEQLEQTELELKKLEAEIADLEDQIQQEESEEQAYWASRNLTDDTLYQTTRHLTFLREKQTHDFQHLERLQRTNVYNDTFCIGHDGYFGTINGLRLGRLPNQNVDWSEINAAWGQTLLLLATVAERLRFTFQGYRLRPQGSTSRIEKLEYPQLSPDAQRQQTAGRDRGLHSASANPEPKVTPLDLFSSGDLAIGRLLNHRRFDSGMVAFLDCLGQLGNYVEKTSTADVSNTKTSMRTAVIRGPSTKRVLPYTIEGDKIGGISIKLGVGFHQDENFTKACKYALTCCKFLLAHVSNLESQKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS39</accession>
    <name>A0A1C1CS39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS39"/>
    <dbReference type="STRING" id="86049.A0A1C1CS39"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08938"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06793"/>
    <dbReference type="eggNOG" id="KOG0427">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="2"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="194" mass="21563" checksum="A4A678066072BE3D" modified="2016-11-02" version="1">MFAAKRLGKELTKAKQKLPPGIDLVKADDFREWLVDLRVLDSNPLYMNQIYRLSFLFSESYPIELTSRPLAQVEAPEVVFIRQSASPADPSNPQSSEKPFAGRPVPIHPHIYSNGIICLDLLGTAGWSPVQSVESVCMSIQSMLTGNTKNERPQGDEQFCQSMGVRGPDGWSGGGYRRGRGLKDVRFAYDDDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS81</accession>
    <name>A0A1C1CS81_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component sensor protein histidine protein kinase (Dhkk, dhkj)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_07912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS81"/>
    <dbReference type="STRING" id="86049.A0A1C1CS81"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07912"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06724"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF72">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="543"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1131"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="824"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1083"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="828"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="838"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1084"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1104"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT51362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1267" mass="138759" checksum="4F8C7569E57AF739" modified="2016-11-02" version="1">MAVLVEGSAVSPQRTDYEVDDARRAREFYHYFQPDNLIQPHLRRRPSVLEISSGEVPDLSRALSPIAQLTTLRMNCRKTMINVMDRDIMYFLSEATKISTEDGEGTYQFVEDPIFLACSSLPLKGRICELTLRLDDSENAAPSPMFVINDLTQSQFAHMEIITGPPYYRFYAGVPIRTRDGINIGSLAVMDTLARPDGLTSAERSFLTTTAGQIMLFLETNRQAIEGRQSRRMAEGLEAFIAGRKSIHDDKTGYMLLKKKSKTTYGLAVPLEGDFSLPPGKPYGVNAVALEHGDDVSTSGQSSETEDVPASDETDCDSRTHTKTFGRAANLLRECLGNLGEDGAVVFLNIGSSLHELRRKRGAALGSAGGVVKGDVQRPVAKPSVVAYSTHTNHVMPERGTDEKMKILEGEMLKDLIGRYPGGRLFTFDASASSSSEDDTNLSKRYGRVSDQPLRHSRRKQLELGALRAMFPAAGQVLFTPLWDATTGSFAYACFVATAVETRSFNSSIELPFLNSFCNTLMGECSRLDTILADKQKSDFVGTISHEMRSPLHGLLASVEFLAETELSSFQRSLISTIDSCGRTLLDTINHVLDFSKINSFQKHWQASNKKHSHGSRRYTYLGPENTSKSISHGAPALLQLLGVVDVSAVLEEVVDGLVLGHTYTSGLDLTDMSREARGRGKTVDYQQPHSDPVKITLDVQKADWTFLTQPGAVRRIIMNLTGNAIKYTNQGSIIVRLQLLDAQEDGSGESMVLTVADTGKGISQEFLNSKLFVPFAQENALAPGTGLGLSIVRSIVLMLGGTIDVKSKLQEGTTVEVTLPVKRPLPGQTSTQTTPYSDGAAGAHSTGGSSVDNSLLTLRDQWSDATVTLWQAEPHSDSELQRIVRSYVQDWYGLQFLDQRLCDSASAVIVEEEDLDPLLNRLVSTPGRRPALVVMCSVLSRHSAALVQSLEDRICSAVEFVSEPCGPHKLARSIRLALERQMNVRAQFAQATDEKVTFPMIEPDLSPILADSESVTEHLAELDLNLPGETDDAKVVQASETFAASQASHNAQMALHDPITALRTPRNHVSEGDAFPFPMHAQENSRMRRESDRRLTPLDTVSDGVTPQSESVGHSLSPVSKPAPSKIDPRVLLVDDNKINLRLLETFLKNKRAYGTIEQAEDGQQAVEAVKAAQEPFDIIFMDISMPVMDGFEATRAIREFEDGCGTKPGAMIIALTGLASARDQSEVFNSGCDIYMTKPVSFKEVGKLLNNWEAHRNNNATSGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSR2</accession>
    <name>A0A1C1CSR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">GUK1</name>
        <name evidence="5" type="ORF">CLCR_09058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSR2"/>
    <dbReference type="STRING" id="86049.A0A1C1CSR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09058"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06561"/>
    <dbReference type="eggNOG" id="KOG0707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="4">
        <location>
            <begin position="10"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="204" mass="22796" checksum="D714C39D4F012806" modified="2016-11-02" version="1">MAPISADDRFRAIVFSGPSGTGKSTLIKRLFAAHPDLFGFSPGEVDGTHYHFVSVEKFESMIAANAFLEHAKFGGNYYGSSKQAVQDVAEGRGKDINGGTAEGKRICIFDIEMEGVKQLKKSSLNPRICFIQPPSLEILEERLRGRGDTDEASIQKRLAQAKNEMEYCKSEGKNDKVIINDDLDRTFRELDEWVMKDISTRRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSS4</accession>
    <name>A0A1C1CSS4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">6-hydroxynicotinate 3-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nicC</name>
        <name evidence="7" type="ORF">CLCR_08604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSS4"/>
    <dbReference type="STRING" id="86049.A0A1C1CSS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08604"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06533"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="296"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="439" mass="48453" checksum="561EF4CB4D4B223A" modified="2016-11-02" version="1">MASIQIVIVGAGIAGLATAISISQKTKHGILILESSPVLTEAGAGVQINASASRLLSTWGLKERFEAVATRPDFLEIRRYDDFELLGLIPSNVKSYSERVRGSPHWLVHRVDYQRILADAAMARGVKIRFGQKLADIDIENVTIMLADGSTLRADLIIGADGIHSRVRRSIPALTKIVPRRTENFCYRALIPRETMMQNASTRGLIENRNQQAWAGQDTHIIAYPIANGRLYNLVMMVPDQGEAPLGKYNEPGDVTDMRKVFKGYNDTVKAVLDAVDSCAKWVIAELPPLPRWSSENGRVILVGDACHAMSPHAASGATASLEDAEVLGLCLATCQGVEDLPRAAADYEHLRKPRCERIQEISRENGTTFSLPDGPAQRARDQAWLAHRMALEKQLAEDAPLLVPEEDMTKQYPHPSVVQWLVGHNITEEAEAYLRRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSY7</accession>
    <name>A0A1C1CSY7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_08539</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSY7"/>
    <dbReference type="STRING" id="86049.A0A1C1CSY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08539"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06483"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="327" mass="35499" checksum="A8CF07B65841B291" modified="2016-11-02" version="1">MRVQIWSGIVFTALYSTYYAQLAGYSTSTSFKLLVVQQVLAMTGNMMSWTLIDRIGRRGLTVYGTLGLTLVLWIMGGLAVGGSRAQLKGAVAMVLLYTWLYNLTLGATAYTYLTEVATARLRAKTIALGLATQSGFGLMWSFVLPYLFNPDEANLGGKVGFIFGGVAIPCVMFLWWYQPETAGRSYDELDEMFMKAVPARAFREYQTDARARRPQFAENLIDIHGAQDDAAEKQRAGLAQLEIVRQLAHGQADGQIAGPEEDHGRLDGLGVVGDVGVGVCGGLGRRARRVRVAPWRGTRRVQAECLGGEARGRDGEGAEPDVAGCDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT18</accession>
    <name>A0A1C1CT18_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT18"/>
    <dbReference type="STRING" id="86049.A0A1C1CT18"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08211"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06457"/>
    <dbReference type="OrthoDB" id="4161531at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="616" mass="65202" checksum="4174706FE811DC7B" modified="2016-11-02" version="1">MSKDREDHHPQLTVGLSHSTSWVRWLGVDPPPSSLNGCVWRPCVSPAGALPAPLPVLSPPRSPFIPRFFSPVLSPPLSPFPLSSYPLPPHSPLPAPSPSSPPSAPLPRPPPPPSRVGVAVGLRLPREQLRSSRSTRNQDHTPRNRGGVPDFDPTEGLPVRRWERQTVRVNQDVSADASESNAQANDKDSDFPWPEQPLPSFFSQLAPHNQELLRRARMGNVNAKLSVWDPKTNSYIPGIELERREAARKMALNKPKHTSIINPDETHPLEDDDDKPDDDADDLLDAEGLPEKRRKTASGSAERVIEVKKWVQVPLAVAEKMPEPKYLADRRPGMESLYKGAYKATNGFGTLGDMGAAATSGATTGYDLGDPTSALAGGSGSGPLNGGADGANVDGTATPARKNIPPRRKKKGGPGRRPKNWKPPTDPNAPPSNENTTADTAGDGRDTVVDDMPAATGEPIDPTGEGPAVQREANSQDGEGEGEGDGEGDGDGDGDGSGSESEGEGSEEGEIAPANAPVQENLAGNVVPAPAPVVETVVETAAAVVVEPEHAPEKEEEEEEEEKQGAEDVVVADVETHEVATEKDAEKTEDVATGLEVDVLGALEAAVDKEAGQSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT39</accession>
    <name>A0A1C1CT39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA interference and protein silencing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT39"/>
    <dbReference type="STRING" id="86049.A0A1C1CT39"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07958"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06432"/>
    <dbReference type="eggNOG" id="KOG1041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="380"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="642"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="970"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1003" mass="109469" checksum="0AB7D2BB38CEF4AF" modified="2016-11-02" version="1">MVRLWAVAAAMGRAISGVSIEGVEAGVGTVEVAAPEVVAEVAAKLNHGTGDSALPDTATRQLENQIQDNVRLEQKKTSPLVARLPLRPGFGTQGREVLLWTNYFQLVSHGGLVLHRYGLDISPDQAGRRPAGKKVRRIIELLLEEHLGQHSPGIATDFKTNLISSAELDIDQGAYTIVYRTEDEDEPEPYAKRYRVRLMRTASLTVSELLDELTSTRAGTLLGSKEEIIQALNIVVGHHPKAASQVASIGSNRHYALNAAASDRMALGAGLAAIRGFFISVRAATGRLLVNVQVKHGAFYEEGPLEQLMAAHLASTGNSKAKLAIFVKKLSVNVTHIIRRNRRGDQIPRIKSISGLATRRDGVGLLHPPNVPELGAGPKRVMFWLESSAEGSSSAQQGGGVGGKKGKKPAKAGPKLPPQGRYTSVYDYFRSEYNIVITNPALPVINVGTRERPSYLPAQVCHVIAGQASNAQLTPSQTQQMIRFAVRRPAQNAQSIVTSGAQMLTANNPTLDAFGIGTTPRLMTVPGRVMNSPSVRYGAQQTISTRFGSWNMDRVKFTTEADLKSWTYLWISTEASSDPWSHEGELQTSVNALTFKLRELGMTCSDCTRGLHITVAPNTIESTIDEALHRFTSTPQREPPKLVLVILPYVDGPIYNRVKHACDVREGLINVCVVASKFARANEQYLINVGLKFNLKLGGLNQSLYPSKLGILSEGKTMVVGIDVTHPSPGSLATAPSVVGVVASVDKWLGQWPAALAIQTARKEMVSGLQALMESRLRMWEKHNGTYPENILIYRDGVSEGQYNLVLDQELPEIRSACTAVYPASRTKKGVPRITIIVVGKRHNTRFYPTRADQADRSSNPQNGTVVDRGVTEARNWDFFLQAHTAIQGTARPAHYYVIFDEIFQARNVQQAPFENAADVLEDLTHNMCYLFGRATKAVSICPPAYYADLVCERARCYLSGVFSPSVTNSAGSMAEGEEAPSREPDSASVTIHQNVRDTMFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT90</accession>
    <name>A0A1C1CT90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT90"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09375"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06403"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="74" mass="8197" checksum="ED84AC8027BE6F73" modified="2016-11-02" version="1">MIYQGYNIKDTTSRIQHQGYNIKLTDSFSSGMKKIIGIGINGGYNWNGGTRQGFKASVLYLSLKSSNEMELSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTN0</accession>
    <name>A0A1C1CTN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_08116</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08116"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06253"/>
    <dbReference type="eggNOG" id="ENOG502QSRA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14474">
        <property type="entry name" value="SPX_YDR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="704"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT51866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="731" mass="81463" checksum="96D98824CE2C2E4E" modified="2016-11-02" version="1">MKFGETFAQRSVPEWAAFNLNYNGIKDVIKRNTSNNVNHGGPVNIPQQGKSRWEDSDQALFDILRDQYDNSSLFLRMKQGEIDRRLAVLKKQIISLRTYADERAFEGDVKASMHGRKHRRLSKEIEELGDLIQKVARFASAQKIAFRKLLKKYTKWTGCTSLQTRTDVELFSSNQLKTDYSNYLQELANLRAILAEELAGPMLRRQQLERLSRQPQEDGTSTTSTRSLIAQINNSIKAAPSAFDAAIMTVPYGEAAGSAMYWIHPDNIDEARALLHRNMKRVDPSSSSPSRAASQESLLSENGLSAPLSSHSSTHMVFFDNAQRFVADASTARPSKIALSAHWTCNKNAAVTLAGLSPSSSGEQTILVDREDLPIALNRELGPKKDSKATTAVQQYLVEHRDVKPLAQVQAHRTRYVGMTNTADVANWATLDSSIMVGAVDMQQLSKLQQVCQGSEAFPYAVLHIRWEFARMPAVVRAFDESYLAYRVHDFTIEDMAIRKVQKDLPRPSWQHLLDLDITKLPLPHAPSFNRLKTTTRMKINASDTRGTSSGPSSSEGQSDSVFSTGTQGNSSTTSEETRALALSSLEEPSPKPNHNARKKRARIVMPEPEPRFRYWNEFDDGDSDVLPQESYAIYVDPNEPTFPGLSEAWKSIRTSWPLKLIIADKGSSDERTPLLYGEDTASIESSDSDSFVEAQQQQLRRGLVWGLVGGVAISFLIGVAVLAFCIFGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTN2</accession>
    <name>A0A1C1CTN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09322"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="103" mass="10984" checksum="7BF8B825B01CECD8" modified="2016-11-02" version="1">MTVVSSSPNSFSFALGIQNATRPRSANVLAAKSRMSSSIRVKEYGFFGAMYPGRLWAGTPSISVGVDGLLLFTGLEIRPLRSVPVDRLGLDLVPSTLSPSRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTY2</accession>
    <name>A0A1C1CTY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-L-rhamnosidase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTY2"/>
    <dbReference type="STRING" id="86049.A0A1C1CTY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08167"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06174"/>
    <dbReference type="eggNOG" id="ENOG502QWE4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000052">
        <property type="entry name" value="Alpha-L-rhamnosidase B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF5">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="1">
        <location>
            <begin position="227"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="2">
        <location>
            <begin position="565"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="683" mass="74586" checksum="FD288E2904A0B3D6" modified="2016-11-02" version="1">MFALLVATVEVVQSQCWRDYPCSGPVDAAFPGPWDQNNYAPASRFVSPASSLIWPNLTSVPYAEVQTISGNGSLVTYDFGKEVGGIVRFSYTSSDAGTLGIAFTESKKFIGYVSDSSNGLFTGSDLWLNLTLTGQPGEYVMPDEVLRGGFRYMTLWLSTNSSTTSFSAQNITVELDFQPTWSNLRAYQGYFHCSDELLNRIWYAGAYTLQTNAVPTDTGRQVPMLVWNWANNATLGPGYSIIVDGAKRDRAVWPGDMGIAVPSAFVSTGDLESVRNALQVMYDYQNTTTGAFDESGPPLSQKNSDTYHMWTMIGSYNYVLYTNDTAWLVALWTKYKHAMEYVVGKIDQSGLMNVTGTRDWARWQQGFHNTEANMILFQTLTTGSKLATWLGDSATAKDWSATVTALAKAINEHTYDATANAYRDNDTTTNLHPQDANSMALLFSVAAPAHVAGIASALVNNWTPIGPVTPELPYNISPFISSFELLGRLAVRDTARALQLLRTLWGWMVNNANSTESTLLEGFLANGSFAYRSDRGYAYDESYVSHAHGWSSGPTSALTHSVLGLDVRSPAGREWTLAPQTGDLAFAEGGFTTVLGRFSAKWRLSEGGVLLTWDTPVDTSGRIVLPVCNMPVSARADGVQVVVQLNGEDNTVHVKPSAVSAFGEYLGEIDVPGGEGRVWYPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU45</accession>
    <name>A0A1C1CU45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU45"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09182"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06100"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="161" mass="18182" checksum="2968C279F1BD581F" modified="2016-11-02" version="1">MEMAASVQLFKIWDHVEERCKLAVIEKLVKWESQLVSIKFPAYGCLYARHFLPDNERKSDLPTDIDQSGSYCIGRSCDPAWSAMPGSVTLAPWLSLTEFGTALAQREIHRISQEPQGVHTVSHRGTAAEHILLLETTIEVMKVLGTHSDLLRHSKRQISRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUF2</accession>
    <name>A0A1C1CUF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09007"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="108" mass="11986" checksum="380B6C68DC894636" modified="2016-11-02" version="1">MSDDGRGERKPGKEGGEAGSYNTGRVRPAFSSWLLVVLKRRADVFPGAPRFFTRSVARTRAPSEQTDNDQGREGNSDSASVAAHRMWTVNLDVANYGQRRYALDLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUS1</accession>
    <name>A0A1C1CUS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_09169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUS1"/>
    <dbReference type="STRING" id="86049.A0A1C1CUS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09169"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05913"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT52249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="170" mass="19827" checksum="CF93FE22576FF2FC" modified="2016-11-02" version="1">MPPQTVKYHAYLRKITRYNPTRGGPFHFRAPARIFYKTVRGMIPHKTARGAAAMERLKVFEGVPPPYDKKQRMVVPQALRVLRLKPGRKYCTVGRLAHEVGWKYQDVVARLEMMGVEEIWLTTFDRLEERRKVKGAAYYERKKAQRKHLAEARKSTADHESSKKLADLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUU9</accession>
    <name>A0A1C1CUU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUU9"/>
    <dbReference type="STRING" id="86049.A0A1C1CUU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08403"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05922"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF4">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT52240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="449" mass="49314" checksum="8A8BCC142889AD78" modified="2016-11-02" version="1">MLVDGGTSTMFWSYTWSITGQFFIVLSLAEMASMAPTAGGQYHWVSEFAPGRYQKALSYTSGWLSSTCWESFVASDCMFAAQLIFALVQLQNPDFEIHNYYTALTSILIGTIVTAINVWGAKKLALLENVFVTLHVASFLVVLVTVAVASPKNDAKEVFTTFADNGGNYPLMGLAVMVGQVPAMWNVLASDAVAHLSEEVKNASVVTPKTMFWAYMLNIPLAFAMLLVFVFAMTDVEAAVGEAFPFVWILQNSLSTAGAQAITAIMFILVFMIAVSCFASTSRQLFAFARDNGMPFPTWLKKVNPQLNVAANSCFVTWGYTVVMSLIYIGSPIAFNAIISLAIVALMATYAISIACVLWRRIVHPSTLPPVYWSLGRWGIAVNTLGLVYAIFAFFWAFWPIYWKPTADEMNWAIVIFTGVMLISAVNYVLSAHKMYTGPVATCEGRKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV50</accession>
    <name>A0A1C1CV50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myocyte-specific enhancer factor 2d</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_09989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV50"/>
    <dbReference type="STRING" id="86049.A0A1C1CV50"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09989"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03767"/>
    <dbReference type="OrthoDB" id="128867at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052254">
        <property type="entry name" value="CUL4-DDB1_E3_ligase_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472:SF1">
        <property type="entry name" value="DDB1 AND CUL4 ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="60850" checksum="58AED72FB2DC05DA" modified="2016-11-02" version="1">MPPNLPGFYFDAEKNRYFKIQANHVAPTGSKYSRQAVKAETVIQKDQRRVERNRRAKVATTVTRSKVLHHPLLSLDRRLGDLRRSARTGVAEYYAASLHGTDALGWPSASSSSSSSSSAPSSITPNSGRFAVDHDSGTLFGDFTWSPSPYHRGARMLALYRDRNPFFDAAAAADDDYQRYPRDDGSWRSTPHPESTGPLYSLKRGHFDTIASVARVQAIVSIGRGMMAWVQSSAREGSPQESCRVKVASCAAASPLGSGHDRVNESAFYNRIVDLAVRPTAAGGGGGGGGASYETTNDNIALATGSSVWLMDVGVTDSRQRHACTQYPLNQADGTNDVMKVHFLDHNVLMCGTRSGKMLLLDVREAPSSSSSSSSSSSSSWWSKPRVVGASTTRIQHSSAITNMRALADRGGQSSSHILLAGLGSTSVYDLRFTPPPSLKCHLPRANSYRQSRPVVCFDIPTPRRQSQYGLGWAYEPELNLVVAASTDYVHNHRVGVWNAGNGRMVAAASPLNDFVFSAPVTCAEIARLRDGPKSVLLGCAGVAGGVIEWSALGGRSLDDHGQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVH2</accession>
    <name>A0A1C1CVH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase/Carboxylesterase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVH2"/>
    <dbReference type="STRING" id="86049.A0A1C1CVH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10660"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03872"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="281" mass="29859" checksum="CB4CB50894E5520A" modified="2016-11-02" version="1">MPTQQPSPTPTPTPIDFPASLKPIIHLPPNNKPTNAIVFFPGLGDTADNFASFPRALNLPDALTITLNPPYPLPFPLGPGAQWSEDLQVDTSTGNLDADSPLTKAAELIAKDVIQEVLLDKFGFRPDHVHLFGFGQGGSLALSVPLHPSLSPLTLGGIVSIGGSLPLSMPLPSASTGTGTNTGTNTGTNTGTNTGTGTGKSTFKNKTPILLLSGSKSPLASVDSSPLKRIKSVYEFVTYHRWKKADDSMPKNREEVLPMMQFWARTLRSRRGVPDDAVEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVL3</accession>
    <name>A0A1C1CVL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10739"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03905"/>
    <dbReference type="eggNOG" id="ENOG502QS7X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43036:SF2">
        <property type="entry name" value="OS04G0481300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43036">
        <property type="entry name" value="OSJNBB0011N17.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="248" mass="28064" checksum="784AB43E62A1008D" modified="2016-11-02" version="1">MDSTPLPPRSYVPKNPDGPFPYTQADLTPTEPGNDTAFYSSPRFVTHIDDNAINNLRRYYDGVLPRRGRILDFCSSWISHYPREVAEATTSGQLEVLGTGMNALELSKNRVLKHWSVQDLNDDPDVRLPGTSAEEQPGPEQKLDASTCVVSIDYLTRPVEVLKSIRRQTKDGGKVHLIVSNRCFPTKVVSRWLQVDEEDRLAMVGDYLWWSGWRNIEIQTLVQGSFMTDPLWVVRAENTGEVTQSVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVM8</accession>
    <name>A0A1C1CVM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PMT2</name>
        <name evidence="16" type="ORF">CLCR_09640</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVM8"/>
    <dbReference type="STRING" id="86049.A0A1C1CVM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09640"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03977"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="672"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="338"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="404"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="468"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT52587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="753" mass="86293" checksum="334D06AE80E8AF24" modified="2016-11-02" version="1">MATSKGGYTTGAGTDEAEVRRRNVASYEKANGQHVYKVEAEDTKKLQKAQTGFIQFLDEWEFLIAPIIFTAFALFTRLWRIGLSPIVTWDEAHFGKFGSHYLKREFYFDVHPPLGKMLVGLSGYLAGYNGSFEFKSGETYPEEVNYTFMRIFNAMFGVATIPLAYYTARELNFRRPAVWLVTLMVLCENSYATISRFILLDSMLLCFTFTTVLCWARFHRLRQKSFSVEWFSWLFLTGLSIGCVCSVKWVGLFATALVGLYTAEDLWNKFGDLKMPKVELAQHVVARVIGLIVVPILVYMFSFYLHFLILENSGPGDAQMSSLFQANLRGTEVGKDSPLEIAMGSKVTIKNMGYGGGLLHSHVQTYPEGSGQQQVTCYHHKDANNDWFFWPNRSQPEFDPEAPLSFVADKQVIRLLHAQTGRNLHSHQVAAPLTKADWEVSCYGNTTVGDEKDHWQIEVVSDAASSDRSRIRTLTTSFRLKHVELGCYLRAGTVNLPQWGFKQIETTCVKKASPRDVYTHWNIESHVNEKLPPGNAAQYRSPFLKDFVHLNVAMMTSNNALVPDPDKQDDLASKFWQWPILHVGLRMCSWEDQITKYFLLGNPIVYWGSTASLGITGLIVAWYLIRWQRGYRELSQVDIDQIHYSGIYPVIGWFFHYFPFLIMGRVTYVHHYYPALYFAILAAGFCLDWTTQRLHRNVRWGVYFILYAVVIGLFVLFSPVVFGMQGSNRQYAYLRWFDRWRISDAKMGETLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVS6</accession>
    <name>A0A1C1CVS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA repair protein RAD9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_09443</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVS6"/>
    <dbReference type="STRING" id="86049.A0A1C1CVS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09443"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04029"/>
    <dbReference type="eggNOG" id="KOG3548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="129353at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17745">
        <property type="entry name" value="BRCT_p53bp1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047249">
        <property type="entry name" value="BRCT_p53bp1-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047252">
        <property type="entry name" value="TP53BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321:SF3">
        <property type="entry name" value="TP53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321">
        <property type="entry name" value="TUMOR SUPPRESSOR P53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="1132"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1090"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1351"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="329"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="579"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="866"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="913"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1090"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT52642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1415" mass="155446" checksum="66577D4DBFB3A324" modified="2016-11-02" version="1">MATESLLNIDIGPLQGDLLREKKSQDQQPCSEHDLDRVDIAAAANKKSPSQAGALESQLPSTVPDSQLNRNFESQWIYLPPAPVSHKTTATRQKMTTQSSDDATQELSQSHYDLILSRSRNEGQLQEQEQSQALHQVWERDFDRGDDAGETQHEGDTGFIDLMSSFEEQKQGEEPEAAVEQTSEHDQRQRRTDSDKEREHELEGSEPIEVDFSPTQPTQSHAALSQFPESQRVKTPVTAGKKRRYNGDFIDSPDLPRNTRPLLRGGEDNAIPMGLSQAFGATQANTSPFVGNVGIGDLDSDRPSPDIHLQPRPMTATSSSPMRPLSTIKRPDRAGTEPLDHYISSKESQARREDARRKQLEDMNVKDGSSGEDDFDIQEDSWYARDRRERERSRRIQAQLSSSSPPAPFTRGVSLSKSSPIRPSARRSSPIRMRSSRQPRPNPESSPTRLNPQSQVTESEEETEQEDNKDMAPTSSSQSSAPVDEEDKENVSDRAIQIPATTIQLRRLTQAPPSQVQESPLLRRGRTLDEGGLSMTLNSSQAFAVADSQPERATKPPQAIAQVPRSSAADDGPDFVPQSPETTPQPTAPVSRNHPSAALPTQVLVSTAEQQGDAVIESVVPVSSSQARQPPNSTIPETSSNAPQDRSGKESEDTPQTCDVESRPEFETAETHVQPSSSTVAHQPTAVELSSPPISTTPPGRRRQRLSDIQGDPSPQKSQSSFDATAHLRLEIQRSPTLLRISARAAKKTRLPELATESARNGVSAQGDVLYRASESPKIQDEANNGDEAQPQHGLEKQSVQPALPGSTFPKRDKRSTATGLSARSSEIGAAPPRRRTSQYELPESPERRVDSSSKRTAKLKRKIESTGNPSDSATNANKRLKLTKSNPSPHDSLPSTPAQPQDMPDPLASDNQDSRHSSPRLESDKDVTNGVGEDLVAPNMVFAAFNGKSRTYHPALCLGRPATDSSRFTIQWEGYDPDEVDEHGVRSLDLRIGDQVKIDMEGFPKVSHVIRGFTDRIPPDNVHLGQVIVTDIRGYQTLVVAPKQRKSLPVEISTEAVKNVPVSAIYLDTIMWGQMKDRVYECNSAVYQGRSTDRSTPVPQISSSSRPSPPPSRSRRGVAVAGPTISTIYTRPDGLFSNMMFAISHYDEPTKQRLVSLVQENGGSILEGSFTDLFVVDSVELKDQYADVGFTALLTDRHMCNVKYLQALALGLPCLSGRWIEASVQTGRLADWNSYLLAAGESTELEGAVKSRLLQLPSSIQGLKVRDMLDLRPKILHNSRVVFVMGKGKTSEDRKPILFLVRALGPSQLTTETNVSGAKEIVQSTDQSKEPVDYVFVGDGDVQAAKRLFSSGATEPKEEQKRLRKGKPKNGRVSGRYETEAKQELDGVLGRAQIICKEDIIQSLILGRLWIGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW96</accession>
    <name>A0A1C1CW96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10810"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="204" mass="23086" checksum="7EA0B638F1382920" modified="2016-11-02" version="1">MSQAKSQTTIRELLVIKEDMAQEDSTPITDNNNNGAFLAGIPMSRYFTAWAARSYPGLYPSQIRLLDEDWPRESLNARPLILPQYLIPASWDSSILGTLFEAMAVRREDRAQLVTLDQILLTVGDKWPNAVAADVTTKLRERAVVVLRRFQGVPGLPIREYFALRLSVYQATRIALRHSSGVLVRLQSYQIQIGDTDFNYSDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWX7</accession>
    <name>A0A1C1CWX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MED9</name>
        <name evidence="10" type="ORF">CLCR_10940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWX7"/>
    <dbReference type="STRING" id="86049.A0A1C1CWX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10940"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04417"/>
    <dbReference type="eggNOG" id="ENOG502SW8C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5414694at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT53083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="156" mass="16742" checksum="4E559EA03FDF7C24" modified="2016-11-02" version="1">MSSPHTHPDVPPLPSPSTFSVLPDIYILLARLNLLHQPQLNGHSQSSQTQGPSTQHLPSQTHAAATGSQIPASILNGASLLDLKDLPGQIYPLKQKLARARAAVEELPDVERTVEEQEAEIRKLAATATALKTRLAGLGAIAREKADVEMTEHEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX16</accession>
    <name>A0A1C1CX16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nudix hydrolase 14, chloroplastic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NUDT14</name>
        <name evidence="5" type="ORF">CLCR_10531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX16"/>
    <dbReference type="STRING" id="86049.A0A1C1CX16"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10531"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04271"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080042">
        <property type="term" value="F:ADP-glucose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080041">
        <property type="term" value="F:ADP-ribose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03424">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5_UGPPase_Nudt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF18">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="142"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT52930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="325" mass="36943" checksum="9849826604C88594" modified="2016-11-02" version="1">MSSFILPDWIDNSPKVEVTIPSNVTKDQLLAFRPFKNWLSTLRQSIAKQQQQQQQQQRRHDQHDQHDQHDQHDQHDQHDQHDQHDQRPPEGHRHCHDSPYQLHHITVRSVEWAGPQRILFVLLDTVVQSASDARPLPGIVFLRGGSVAVLMIVRPDDDDDDDDRSKRFVVMTQQPRVPAGSLAFCEIPAGMIDDDEDAFVGAAATEIREETGLVVRREELVDMTELAVAVAVAGRDDGDHHLQGAVYPSPGGCDEFVALFFCEKSMARRDIDRLRGKLTGNRTEGEKIQVRLVEYEHLWREGARDAKTLAAWALYENLVREGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX57</accession>
    <name>A0A1C1CX57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX57"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10043"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00072"/>
    <dbReference type="OrthoDB" id="4120541at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="538" mass="58062" checksum="3F59558C696D968E" modified="2016-11-02" version="1">MAIAKDSPSAKVDPPGPLMMIMRPEETVSSLMNELRQSRPRRRRITIGGSDRRTNDGHGSTLGDHRAPNSVPQRPSPISSKQCTPEPDTQLGFMPRQHITPKTQAVRRPYPPSSWKSTSTIESVTLDVGGASILDAPERTVIQSQSAQRHVGRGGGKDNITLGLFVDTVTAASGRAQSENGLAVDQHARTSSGRQYTIGSSRCAGPAGMGSSEASSDISSPVNDRLVTGKAPLPDPEVAYAQAFHYTTCPHVSPPKSRPLNVQPALVPRQRRPLEVQGLRVDPRTAPPDIYVLDGACFDCDLSARRQAESDILETYTHKLENLTIQLSLLQRDIAAEHSGPSPNRGNGALTAFTLPSTLELSTEATQGILEIEEQLSELVKKRDEDIRQVWSGFTARWGPGTVRIQRDESNSTPGRAESPSTTRTSSSTNSLGVPSANTTPEEVPAMASRVSRGAINPVSPSRQSSFTARTRASSIQGRYSDGSRNVGVESSVDRVKGRGRMLVDWIRPGRRESKSGGGKQAHRRKGSRQGRQADNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXB3</accession>
    <name>A0A1C1CXB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aconitate hydratase, mitochondrial</fullName>
            <ecNumber evidence="5">4.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Citrate hydro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ACO1</name>
        <name evidence="19" type="ORF">CLCR_10048</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXB3"/>
    <dbReference type="STRING" id="86049.A0A1C1CXB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10048"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04424"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="17">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="18">
        <location>
            <begin position="298"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="231"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCT53091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="496" mass="54663" checksum="13F797C39EB55086" modified="2016-11-02" version="1">MGAEIGATTSLFPFNDRMHDYLAATKRGAIGDFARSYAAELHEDEGAEYDQLIEINLSELEPHINGPFTPDLATPISKFKQAVKDNKWPEELKVGLIGSCTNSSYEDMSRGASIAQDAMDHGVKAKSLFTVTPGSEQIRATIERDGQLKTFEEFGGIVLANACGPCIGQWDRRDVKKGEPNSIISSYNRNFTGRNDANPATHSFVTSPDLVVAMTIAGTLNFNPLTDTLKDKDGNDFKLKPPTGDGLPKNGYDPGQDTYQPPPEERESVEVQVSPTSDRLQVLQPFEPWDGKDFHDLPILIKTKGKTTTDHISMAGPWLKYRGHLDNISNNMLIGAINAANGEANKVKNFKTGEYDAVPATARQYKKEGIKWVVIGDYNYGEGSSREHAALEPRHLGGIAIITRSFARIHETNLKKQGMLPLTFSNPEDYDKINPDDKVDLLVTGLEVGKPLIMKVHPKDGEPWDCELSHTFNAGQIEWFKNGSALNTMAKNQKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXF0</accession>
    <name>A0A1C1CXF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Caffeine resistance protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">caf5</name>
        <name evidence="6" type="ORF">CLCR_09947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXF0"/>
    <dbReference type="STRING" id="86049.A0A1C1CXF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09947"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00104"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT53131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="550" mass="60765" checksum="77041DD717EFF5B4" modified="2016-11-02" version="1">MLEHIKETPAGQFLRFLGFQQPWLMYPEEQPDFQPGVMPTMVSEASASASETDLEKILPEGSATIRATEKDIMPRRSQSPDTAEVFVVAFTENDLDNPRNWPHGKKMWTLAVVNLYTFCVYCTASIVTPTAEAMTVRFNVSLVVASLGLSMYVVGYAVGPMFLSPISEIPRIGRNPPYLYGFAAFFVVSIALAFVDSFPAIIVLRWLQGLTGSPALASGAASIEDIYDIYTAPHGYVWWIAAMYCGPAIGPLMAGYAVADSWRWPLYEVIIMSGIILCLLPFLPETYPGTILLRRAQRLRKTTGQGRYQTETELHPTRFSKVLFEALIRPLEITMKDPAVLYAALYGGLVHATYYSFFEAFPLVYLGTYGMSLGELGLIFVSLMTGCIVGLAAYYAYLRSWFIPHARKYHADQGQPVEQEEWLRPGLCGVWGPPAGLLLFAWTARAGVHWIVPTVGINIWAAGSFCMFQSIICYVALAYPKYVASLFAANDFVRSMMAAGFVQFSHSMYVDLGIAKGVTVIAGLSGAGVAGMYGLYYFGAWLRARSKFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY33</accession>
    <name>A0A1C1CY33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY33"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10565"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00411"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="319" mass="35993" checksum="CDFF10462DE08E21" modified="2016-11-02" version="1">MHSQPKIHLVRHAQGFHNLGTEFHSLPDPRLTPLGESQCAKLQEEHFPAERQESISLITASPLTRTLHTAFLTFKPALTSKSVKCKPTILAIPDAQETSDYPCDTGSDVPVLKAFVEEQKWPVDLSLLTDTWNVKTLENRYSPASAAIKARARDCRKLLREKARELARGGDDNVEIVLVTHGGYLHYLTDDWEDAAKLSGTGWENTEYRTYTFETSFLSDDDSEAHLTETLDSRHRRGISHPMPDHEKQKELFERMMQGWEDQGLQNPAKLSPAVVDEEAEEHGQQPADLQRHVTHAADEAEKTEINTQTQPQSVTVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY34</accession>
    <name>A0A1C1CY34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY34"/>
    <dbReference type="STRING" id="86049.A0A1C1CY34"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10196"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00365"/>
    <dbReference type="eggNOG" id="ENOG502S30A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="123"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="369" mass="40976" checksum="F4B95E2F6D1C460A" modified="2016-11-02" version="1">MTTPPTADQALSTPIHQVSFLEKLDVFPGLLSIVGTVLYTAATAPFRGESGAYTYGQHISFAAIRKMVQRLSTLQLHYIGAPFSKVYEKWCKDTGMQPNFVTLKSGVKAFWVGDPQSAKYICVYYHGGGFSLDGDDTHLKFWHGVQNDAKASDITIAFLFLEYTLVPHATYPKIMYEAVEAVKYVMEDMKRPAAQIILAGDSAGANMCLGVLSQIMHPSPDFPELKLGEGEKLKGIVAVAPWVSFRLEWPSEAKNRYKDLVSQYAGEKWSKDYLAGKPTTPYAEPLTAPAEWWKDAKVEQILAVSGANEILLDSISEWVEKYKSVNPDNLTYVIGSNEAHIAPIIHLRFNDTAETEQGKAIKSWIKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYR5</accession>
    <name>A0A1C1CYR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sporulation protein RMD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RMD1</name>
        <name evidence="5" type="ORF">CLCR_09885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYR5"/>
    <dbReference type="STRING" id="86049.A0A1C1CYR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09885"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00547"/>
    <dbReference type="eggNOG" id="KOG2861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF15">
        <property type="entry name" value="SPORULATION PROTEIN RMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="326"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="551" mass="61437" checksum="FF1011B774F60461" modified="2016-11-02" version="1">MATTVSESSPLLPQHNSPGGSPSRPGLRASRTVTFNPLTSVSTQSGATSSAALRPSQSPSSALTSSSQPVREQQPMLSAFNSKLRRRNSHGAPLPTTQSFSGAPRAGAQRTTKTTEKLKILPNPDIEEEEEADEESGRDVYAQFTRIKDPTARRDAARLGKADRDRLPRVTAYCMAQGYRLEGIMKFMKSRARTRGANPKLFDECLYSPYDYEYLKKNKGSERGSSPVQERLARVMASPRMGPGERRFSDSAVEVEDNNKHRRENLIDLQDELGPPAGATPMEPGTLEDLAIVASRSSTDLRHPDGDEMHDRSNSELSTTVHTPEIFIFDYGTVVIWGMTVQQEQRFLHDMSKFSDAPLPTESVQTENFNFYYTKEYQARIYNDFISLRDPRNYMTKLAISHALSQSVKTSLFEDLVSETIETTSPLPALIAQTGSVNLTRRQLNMQIGELFILRINIHLQGSVLDSPELMWAEPHLEPVYAAVRSYLEIEQRVGLLTERLDVIADLLAVLREQGSRRHGEVLEWIVIILIAAEILVAAINIVVDLYAGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYT2</accession>
    <name>A0A1C1CYT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_09451</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYT2"/>
    <dbReference type="STRING" id="86049.A0A1C1CYT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09451"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00643"/>
    <dbReference type="eggNOG" id="ENOG502QVPZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20774at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="3">
        <location>
            <begin position="39"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="4">
        <location>
            <begin position="543"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1299" mass="144256" checksum="77936C1C55D168A9" modified="2016-11-02" version="1">MANASDRGRKGRTNNPAQDRPPIQERVGILSRTLTSSSSIRWILPARLRSPSKNDVVFVGHTFVQLHEFQDSGQLVDTTAKLDFGTTITDAKVISADLETIPVVDAILKQERDLEQFSIRGQPVGDGQPPQLLVLVTRDNEMIYVYARENSIGDAQLVFAKRPFLRGSDLPSSECRDIAVDPQSRALAVASPSGYVVVFKLRCLDEIKAEIDGWDPLNPASFCPAREQRFISVDGNILLMSFLPSPDADPSKVVLLLLAYSGDERKETYQYVLTWDTRLPLKTIKHMSCSGRKLQEDQLPTMLIPSTRAYSYMVVMPSSITYYENVQSSETKRVNCAFAKDNEEPLEWVQWSRPRRHVHYLQRRDDIVLLREDGLLRNFLFDKHSSKIFSTNNIIGHLGFSVDTAFCMLSGPPGKGGDILVVGGSMTDGGVFHVSARGSPERLQPIETLAPLNDIVTGPPIAVDGEDIAAQQGMPGRLYTCSGPHDRKGQVSEIRYGFEAQIGWKMEFPNAALVERLFSLELPRISQVLLLASHTASSSMVAFELETQDIAFTDSDSHPGFDFDHPTLAATVFNQDIVIQVTTAGISAILVEADDQVTRLRHLKSTIEHATISVGDDPAIAAVRACDTGLDLCIIEVDTADDGQPQVDVTQLVRLEHIPNSICCMHTDHGRLVVIGTATGELLCYDENLKPVFELRIQDLHPEANNAAVSSLVALGPHLVGPTLLLCGLRSGTVLCVELKIQSKNGTRIDVRCDELFRVGATAVQIIEERGRPDGSGNPSALVLCEYTIYRVTLHANSAVVDFTFSPIWVVDRTNPSALPLVNALHRIPKLESKYEQPGGFLICATEAEILFCSVVAQEHGIARHLHFDGVPKRLLYSQFLEKFAVAYSREAYPYEPPLRRPTNVPLLPGEKDATDRPSEKVRQIGLQLVTRNLSYPAGRKGEDVTFSTIVTGDSSAILHDFIDWRPTDDVFHYEWLVLALELPGMHGRVVCVNAKTLGKGKPDADAKVAFHDKQPVTAICAYKKSSLLIACGKEIILRHLDFKTRRWETLSRHAIPSMANAISCQGSLICVATREHSLFVLVDRNDRLCQHKCDAGMRYAKDVAVLDLSTAVFAAADAAGTDIVGFSGLNKANPDATPLFHAKMPGHIHRFRLDSSRGSRRNERTRFYGATMDGTLFHFTLLKHKEWKLLHFIEEMSYLDRKAITAVPMKRRDADGKGYLWKPPPFRPKDMHVRGDRLLMMIEDGPYNLRNVLKGSPRLETFNALVRETLAATDEPVEVAIAWMRKFLRYPPSAMTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ52</accession>
    <name>A0A1C1CZ52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitronate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_10433</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ52"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ52"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10433"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00665"/>
    <dbReference type="eggNOG" id="ENOG502RHJM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="363" mass="38553" checksum="1BD9C788D6974798" modified="2016-11-02" version="1">MTSPAIQSLKSTYKFLKTPIIVSAPMRVFAGPDLAVATSRAGGLGFIGPGVKPADLGSKLERAQALLDQAPIDHNSKSPQPSSSHILPIGVGFQLFDGDLQIATSTVRKYKPAAAWLFVPKTGQSEVDQWTLGLREASPSTKIWLQVGSVAEAMAAAESKHAPDVLVIQGIDAGGHGLRKGAGIISLLPEVWDALRKIGSDIPLFGAGGIADGRGVAAVLGTGVAAGAVMGTRFLASKEADVKSDYQNDVLRVVDGGQSTIRTDLFDRLQERHDWPERYDGRAIINDSVRDELAGLDFQENKKLFKSQQQDGSLGWGDDGRMTAYVGSAVGLVTSVERAQDIIESAREDAKQALRKAVAELDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZQ3</accession>
    <name>A0A1C1CZQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_09900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZQ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CZQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09900"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00870"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="258"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="462"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="562"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="462"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT53962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="605" mass="66686" checksum="EDD2CA6431E63096" modified="2016-11-02" version="1">MQPTSEPGMSTFPGYKPVDGDGDIFMADAQPREPSPRDQGIPATTDGSHPSPRGSSQLALQSLPDAIPFRSRPTPFGRPPPAPSTSSARLNLAPSPFGNHLRYLPQPNPGSGAIVYPPMRLSPQHTRSSTPGDAEPPTLPPLSSIIPGPYGREGFQHATTQSAPLSKDGRSSGIIGANQGSPPHDTAHPHGVGLSLSSDFPHPPPVWDISHGLPAWEAFLTASPIPNGPFYFAHPARPPRSQTPPHIHRRRLTRPATPKVSCTVCLEEFKRDDLLQLACNCRYCTPCLNLSFRAGCANMASFPPKCCAKPLRISVWGSMLEPDILDRYKEIEAEFSTNRPLYCASPKCSTFIPESAMVPQDELGLCPKCATSTCKHCRRLMDDHAVWDIAERICPKEEEGLTKLYELGSEKKWKQCPTCLNMVEKTEGCNHMDCICGVEFCYRCGNLFDEDDACECELNTWDNEDDGEEEEGDEEEDDDDDDDEDEDEHDVDEESDEDEWPNYRLAVDLAGRPRCLHPDLSPLGAHHHTCHGCLQRNLLLTCEDCALELCQACVDKIRNVRGGEGDDGEDGSMDLDQRGMERGSRLDGIRGWPNNPNPYALTPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D050</accession>
    <name>A0A1C1D050_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D050"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00303"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09427"/>
    <dbReference type="eggNOG" id="ENOG502RPHS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5279542at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="340" mass="37634" checksum="AC2ECDB9C4F32301" modified="2016-11-02" version="1">MIGSKTLILTSTYPAELSLRPTSHERLRRRFITILHGASWLASVIAISLFAAAIPSWNQNFFHNTGPNRGDWTDGMPLGPLTFAMLYHALVLIRAQIQKAQRSNVSTSHGPSLNQTWLVIHTTVPCLVLLSLLPALLLAAYGSLFRFWQPAVRTQSGILVCNMLNIFARECEPTLYSIGSLQIAGITFGILVWVLHFALLLVSLRKLRRSRLAKQLQREKMAQYARREERSSRASRRGYGSARGSTDRHGAGDHGAWHQHPRPDRYRRSGSSSSSNPKSRSGSQSGSRSNSLVGGVSEARLGRAETSPQGGRQQQNPPEVPIFFIQAPEESHSPPSRRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0H6</accession>
    <name>A0A1C1D0H6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0H6"/>
    <dbReference type="STRING" id="86049.A0A1C1D0H6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00161"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02556"/>
    <dbReference type="eggNOG" id="ENOG502SQ1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="268"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="807" mass="92145" checksum="44C3A8DBF7DA3469" modified="2016-11-02" version="1">MNAPTVRKLSERETSPTPLDDGENGLRNKRPRFVTDLSSPLCEVCQQLDLDAKFDRTHEAYRQVRAGVVSPPEDIYKASDGSWYYADAILAHRFNDSLSKPSDCPLCEFFRSLRVQPDSHKRHKLLAFRCSDSWLFRAGWLRERNPQKYEHNRDSVFMAVVPDLDTLPSCGYEANWLDHDVPATGAIYRLRPMDDSQIAKEKQILLARELDEGPNLGGARQWLGMCQKDHGSCCKRRTSHEPILSGFRLVDCTKEPPVVEEKPWGTTYLALSYVWGTTPKDLAHWPETVLDAVEVTKKLGFDYLWVDRLCINQADADEMAHLISRMTTIYEAAELTIVAAAGSGASRGLPGVRSRPRRPQPKYYLDSGSVLLSMLRDPRRDILESTYWTRGWTYQEGVLSNRRLVFTDEQMYWECRNMAAQESIDVVVFHVPVTKAEDDSEFVMADFMLSGIFKGDAYSGSRGDAQDSLVTQDEGHRLAYGFPTQEEVTVRAQLRGLNEHTREYSKRQLTRDEDTLSALQGIFGLYAQTRQLYLLHGLPVWTDDIVQGRSGAQITFALSVSSWYHRTSSDLLMYVSEACRRKSNLPSWTWAGWVGTVSWRALPNLEHCAYMSDLINAESLKLLWAADISLYGADYARPIRLQETHSAALLVSGAPRTLLEIENPFLLNKFQRVEQVKKEWYWAKAIGRPGRQKAKAQELSWDAKWYRIGGRLSCVGTSVAMTEREWTAKHVSGELVSVLMFAGQYLVNEHGTARFLTLRRVPLSMPERWERVGTLYLVIPFNQDCRDVQEFLGKIPARRQHRSFVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0Z5</accession>
    <name>A0A1C1D0Z5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0Z5"/>
    <dbReference type="STRING" id="86049.A0A1C1D0Z5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00910"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01646"/>
    <dbReference type="eggNOG" id="ENOG502RXC9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT54371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="306" mass="33650" checksum="D5481EC95DE8A066" modified="2016-11-02" version="1">MSNLKRILITGATGKQGGALLSALLKSPPTPPFHLVALTRNSKSPQALALAQKPNVTVIEGDLNNCEAIFKASPEPFHGVFSVQVPLKPKVEEQQGKALVDAAAAHGVNHFVYTSAERGGPQQSDRSGTVVKHFISKFNIENHLKQVSQKGGGRMQWTIIRPVAFMENLTPDFIGRAFATMWQLNGMDSKLQLVSSVDIGILAADVFKNQNAYAGKALSFATDELTPQEANAIFKRVVGTDMPTTYPVVGRLIKFILHEQLGAMFDWFKSDGFGANPREYKDNFPEMQDFETWLRRSSKFAKSASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D131</accession>
    <name>A0A1C1D131_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CLCR_00963</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D131"/>
    <dbReference type="STRING" id="86049.A0A1C1D131"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00963"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10090"/>
    <dbReference type="eggNOG" id="KOG1783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000037">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="17">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT54569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="135" mass="14359" checksum="19009FD65987944E" modified="2016-11-02" version="1">MAENHTTTSTTSASASASADPKDPASFLSSIIGVPVTVKLNSGVVYKGELQSVDGYMNIALEKCAEYVEGKLRRRYGDAFVRGNNEANIWMKFLDGAGGGERLFESERDSGRLNAEGAGSRNVAGNYSSIDSIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1C3</accession>
    <name>A0A1C1D1C3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1C3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00999"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="112" mass="12400" checksum="029D101A157E4AED" modified="2016-11-02" version="1">MYLWTLFYLGKYHHRCNLVLISGFCPSAQVAVDSPLQTVAAMCGTAPRHDEEQDHQSGNYTNTIFVCNSSQFVSLAETLSKMNSTQQRLSKGALLAYAPSRLISPQLTAINM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1I6</accession>
    <name>A0A1C1D1I6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide lyase family 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1I6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00931"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10125"/>
    <dbReference type="eggNOG" id="ENOG502QVMP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="77013at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014895">
        <property type="entry name" value="Alginate_lyase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08787">
        <property type="entry name" value="Alginate_lyase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651202" evidence="1">
        <location>
            <begin position="22"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase 2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="256" mass="27061" checksum="B7117E7241B5A381" modified="2016-11-02" version="1">MPTFSRACSILILGFSCLAGAQNPSCAPGGNFNLKPWMLQLPIGSTGNPTTISSSQLQGCSGYQDNGHHYFFTESGDGALVMKVPGSPASSGCVTTAHSTHCRTELREANPSTGGAASWQPSSSRNRLAVTLAVTVPDNSGHGTVIGQIHIDDSVSVKPVCELYYNKAGDVVMGVEQTTDGGNSIFTSIGNIPVGQTFSYEIRYESNVLSVSLNGGAPRELDTYELNSPPSYFKVGNYNQGDSPSDVHFFSIDVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1S7</accession>
    <name>A0A1C1D1S7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1S7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03147"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04740"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="177" mass="19193" checksum="137C0345DEE14CEE" modified="2016-11-02" version="1">MSHSAYFLCEVKESGVSKGLAVIRCYPWDSKTMNKSTFPTQSYGELLPGLASFETQTKANYKKKTFDVDFLAVPFGYAQGAAALGTKPAADYNRHLLFFIPIGSTSSTFGAQIPGSYAGTLIPSAAWKDPMTAHWQQVYRGNDQPFDKSFGTSDSNRKYHVKYIFTDGAAPGSGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1W0</accession>
    <name>A0A1C1D1W0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Initiation-specific alpha-1,6-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">och1</name>
        <name evidence="12" type="ORF">CLCR_03001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1W0"/>
    <dbReference type="STRING" id="86049.A0A1C1D1W0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03001"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04783"/>
    <dbReference type="eggNOG" id="ENOG502QW2I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000002">
        <property type="entry name" value="Initiation-specific alpha-1,6-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651206" evidence="11">
        <location>
            <begin position="30"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT54675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="364" mass="41300" checksum="552CA36A42DCA268" modified="2016-11-02" version="1">MALSNSWKRPALVAGVFIILFLLLRQSSVAPGTPEVALTAEQGPPARSYPPPKVPKAAHEAQQLIHDVPRKSLDEKLRYHFPYDIESKFPAYIWQTWKYGPDSGKFEERLRPFEASWSTLHPGFVHEVITDEAALHVISYLYASVPEVVEAYEAMPLPVIKADFFRYLILLARGGIYSDIDTQALKPATEWLPPNLDTSTVGLVVGIEADPDREDWNDWYARRIQFCQWTIQSKPGHPVLRDIVATITRDTLRMKEARSLRKGKEPPKSIMEYTGPGVWTDALFSYFNNREYFDFSARGTNVSYSDFFGIREHKKIGDVVVLPITSFSPGVGQMGAEGTDDPMAFVKHEFDGSWKPESERMKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1W1</accession>
    <name>A0A1C1D1W1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF410 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1W1"/>
    <dbReference type="STRING" id="86049.A0A1C1D1W1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02990"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04790"/>
    <dbReference type="eggNOG" id="KOG3024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="348" mass="37592" checksum="657524231E800F4A" modified="2016-11-02" version="1">MSAKIAKTIARQKEKIAEGNFYEAHQQLRVITARYLKAQDYPSSCDVLYNGALLLLRAGQGGSGGDLAVMLINDVYVKGEYPCTDENKKRVLEIFHAFPSEEPTRKRFVGDMVSWSAKYGDLERGDADIHHEVGKAFAEEGEAYDAERHLIIGTSASAPILASVHYNWYKTDQPHLAAIYASRSVLPYLLVGNLAAANLALSTFTSHLTTSNPALLAMSQPLESAKSGLSLRIFPSIPLLNFLSLLLLATQKADSSLFRQLAKYYAPHLKEVEGLWSEALAHIGEIWFGIKIPRQSGNPLFDMMGSMLFGGGGGGGGAKPGGTPRSGTPGPGGAAKKEIEKPPAMDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D264</accession>
    <name>A0A1C1D264_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D264"/>
    <dbReference type="STRING" id="86049.A0A1C1D264"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02912"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04904"/>
    <dbReference type="eggNOG" id="ENOG502SH9S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2951834at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="452" mass="50556" checksum="D2CB96A084ABFAE4" modified="2016-11-02" version="1">MAPTTRKRAKTAATPDSAGADTGGTSHVVEEGSGCDDKIDNTFEDAFPDAQSDHDSDDSDYVANGRKKRKRKSDKGQKAKPKPLTAFEGPPPLPVGDLSDNEYARNEDATAAESDDDGLWSTSRRSNAAALAVAKENKVAPELSIQITGNGEAKTLISHNLATLLSNAGMTNLTLTLPAAFAGEKADSNMDNLANTTPGQKKKKKQRKKKSGFFKTLSPELRLRIYKQLSKLDKPIEFGKSDVSASAQFLRTCKQAHVEGREILYGENSFHFTRDTRTRGKFYDKVWKEIGYKDIRRFLQDIGPDNIACLKHISFQLTDAPDNRTRSVPGQITERRFVEDPHLQEIFRLIAANATLKTLALQFAGRAMVTQYDRRFLRALTEMKCYKLVIINQFFSSTHKCAYNLKDKLKQVMWVRDEKGNRVKLEEARKPVKMVYSVGPAAPFMVNWEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2B9</accession>
    <name>A0A1C1D2B9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2 type zinc finger containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_02731</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2B9"/>
    <dbReference type="STRING" id="86049.A0A1C1D2B9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02731"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05017"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF22">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="363"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="538"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT54926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1012" mass="112600" checksum="4F1270EF04CE01E6" modified="2016-11-02" version="1">MPFRTFGISADVQEAGNGRSENEACSPLCSAPQFISSSPAFLGIRPRMSKYPSLRIASPHPAIERRLYEAMDATQLTGGGRVKRKQSGNKNKTLPCPHCQRLFARLEHLQRHIRTHTKEKPFVCEICSKTFARSDLLVRHERLVHPGEEEQHTTRKSHKHHLQNANNAKEAAARVQAQVQQAVGVDSDPMDLTPQQSQPLLSPQATAHDGRGMMDMLDPQLMQPANGINSVEGMSAHHSSAINAPSLDPSWGYDLNLLSHAASHVASSGQDQYMSGLPVTQEQLNEPMQQLMPAVTDGQYQPRMLTEGYGQSTSMFETPDLGDPMQDFTVFLDSVGLSSEWYANMFGNDQVDNYNSPTELRGDHLNISRPHLNGEHSTDSKLAVPQEETSTFSRFGSRLPSLQPEPRDPDFTRPDPPRSTTVEEAEAKVVRTTWDVSDSDRSIFASRLQAFDNVMPKGFIPPSRHSLSRYLAGYVNGFHEHLPFIHVPTLQVAASGPELVLALAAVGAQYRFENSRGIELFYAAKAVVLEQIRRRDESSTPHLWNRPRTGSMVQSPGGGFANQSHSSSSPFQQVSPEEAIAADSKEQMDSIQALLLLTAFATWERHTELLREALAFQSILARLVREAGLTSPEIMQSPEELTWEDWIQIEGDKRTKLIVYCFFNLHSITWNVPPLILNSEIKLNLPDPANEWKATTAEQWQKLRQANAAPQMPFQTAFSRLFTKQNQATSTPISPLGNYILVHALIQQIFFARQLSLAWPGVAGSSLRMEDIAVLDRGLSSWKAGWKRAPESSLDPQNPNGPVAFTSTALLGLAYIRLHVDMGPLRHLETRDATQIASALLNTSDIRRDPRLTPALLHSAHALSIPVRLGIDFVARTQTFFWSIQHSLCSLECAFLLSKWLYVLSNLKSSGGAPVTEHERKLLLWVRSLLDETEMTVPLNGDANDHTVLNESRELLDDTEKMRQLSVAVVRVWSKTFKGNTSWAIVDMIGSALEIYADILETQGEMAAASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2I3</accession>
    <name>A0A1C1D2I3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_02887</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2I3"/>
    <dbReference type="STRING" id="86049.A0A1C1D2I3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02887"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04980"/>
    <dbReference type="eggNOG" id="KOG2895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="504"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT54890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="551" mass="62467" checksum="561313B3055B77E7" modified="2016-11-02" version="1">MSEPIPIPRSKSGSALDEGLASDVAGSLGSDIGGSSNGGALTPGYQSGYQSSSPGSPMMLSRNSSYIGSQSMQEDWEVPLDKLSFFDIFDNLALPAKLDKWQATIQAQKEKLARQQERIRTTGNNARDRAVAEWRKRVPSADEQLAKYRSRMKRSVDDLNKRWNEVVTISIREKVSFISAVLNVFVSGYLIGAAPQYFYWWYTIQLMYFMPIRAYTYHRKGYHYFLADLCYFVNLLDLLAIWAFPRSKRLLISAYCLAYGNNAVAIVMWRNSLVFHSMDKVVSLFIHVMPPVALHCIVHLTPDEYLLKRFPAVYTIKYSLKGSPEHYSLWAMLVWATVPYAVWQLSYHFFITVRRKEKIAAGRPTSFTWLRRSYAKTTIGKFVNSLPIYLQEPAFMAIQYSYAILTIIPCPLWFWYRWASAGFLLTVFSWSVWNGANYYMDVFGKRFQKELEQLKKDVAKWQNSPAAMFSPPTGPLDAELSPHITRGDAAKGHGKRESIDKIPLLDEMGQPQENGHEDSSARATGAELLSAADEGILDRKSVTTPLAEGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2M6</accession>
    <name>A0A1C1D2M6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2M6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02895"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05114"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT55022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="529" mass="58458" checksum="906EEE4DDE118D18" modified="2016-11-02" version="1">MYFEIDVTNTTSVYLAFQRDQDDPRTSAGALSVQDSIGLFVEIDDDLVFGVQQPFPIVQVAENLDPSRTYRLRVTQTGTYPLGDSSFRFQGVWLDRPPSQKDGPLLLDPANSAVGSTPGTLIPQSDGPEGAPQPQDSLLPRRRAKPLIELFTCEVDRWLHCHDPAQDAAELAKERVHTWYKRLESELGADVALVASTGGYFSRDWFHFKGDGFPDAPVSLYFFTYRIGCVGRPEDWLKRHPWPFKSYRPAVLILQLGFSDFTHIFKMRPTKPHLDDFLDSFIKDYVALVNKIRARAYPSDGTTTNARSNDDDAAPDSDGSYSYNSAPSTLPIFLITPFSAHRVSVTRKLTLAKVMTDALARIVATLHAQGDISTHLIDTAGWLDPRRDFEKPPGFRPPWYPPHNQELLRRLTEAAATKVATLLASHVCPYIQQGGGGGGGGGGGEGSTADGPARDSDSNSNGSAVAPAAFGDCAFDQYDSYLGNVYVPEGVQLDRALLERRIESIKERFQLVTPAQLKAEGETFLHRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2Z8</accession>
    <name>A0A1C1D2Z8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2Z8"/>
    <dbReference type="STRING" id="86049.A0A1C1D2Z8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02729"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05120"/>
    <dbReference type="eggNOG" id="ENOG502SFK0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5376710at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT55028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1042" mass="113617" checksum="A0389BF87A481FEA" modified="2016-11-02" version="1">MTSVLRLGSKDRSSFLFFKRQNNASDVPTDSLAHCLPDISPLDTRSFAGLFDEFMSNENHDLSRAPQTRQTAPTHRTPSVIRPSVGTQAPHLPATAVDTKVDYLKVNITRNDSTASSCYSQPSHRDSDFSPLVTRQSSSSSYTLEPSPSLSRTTTRTPKPLIIPRRSAQNLTTHLTESPISAQASPARADSSLKRVVSVAPNLDKPLPPGPRGDAKRPSASVPDLLLRPPPAELPSELPARAVPETSGPIQRTFSQPAKMASAREGSDGEAAIGKAMIWSSRSIREARLGKAVASGLYRNRSASDTDVPQHGRPLNEKSRRHTVDMQKLASTVPSSSRSAQTGRKQNNRPITAATAERVIYRIMCSVHTAQDLQATAMVSKGFYRTFQRNESKLVSHLMFKSSRAAWELRRSTLALRGSNDFLLKDYRRDCRTLDALKAFIVAHCSASCKPSTLIGLLGEDDVRAVQINDALWRIWTFCSLFGNTVGQSKPSQTEIDWLNGSRAASNKHLGAGFAIGNGKGLTIHELEDMNEMWQCLQVLVSGFHGREQEAKRYGVFDNWHLRETTTDSQHLHEWTSYLLALGPQTVLTLSGHSFDQAKMLGLTSWPLPPAGQSRSSFLTAAIAQVYQERILEDATRRASQMSFRQPAPARAPSHRPTRSLDEKQLAPMVPRHAGKLQTQSLRIDTSAQRRRPVSTIATNVTGNVSLAIRPDRDPASTRMEIRPDCDPAWRTSQAPSILPTSPTVDPTVYYSLSTTATASAKLGATLFPMDYASPAPRVPFPVPERTMASVSEVVDPVDKAMNLLVGELGFAETRARKALAMCDTGSGIDLQKAIELLNVDSRDLKPKNALPVELPTPGGLASPAKAQMLQPPKAYCDGYCKRSSTLSHSRNQSTGTAGTATDDSVSPISIFNDAEWADTISPLAGSSLSGSRKGTMNRVSSKAKAWKVLGLDNSPKGKNSVLRIDEYQAKVERRKSMRAAAFGGEHSPKIKEGLGKNLLSLGLGVGSSAAAKSVEEQLDRARAEERRKKEKNQASGMRRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D3K2</accession>
    <name>A0A1C1D3K2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein kinase ppk6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000001">
        <property type="protein sequence ID" value="OCT55135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D3K2"/>
    <dbReference type="STRING" id="86049.A0A1C1D3K2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00021"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00020"/>
    <dbReference type="eggNOG" id="ENOG502SAHR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5420391at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42084:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PPK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42084">
        <property type="entry name" value="YALI0E26631P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT55135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="49264" checksum="BDC1D84A1FB3D625" modified="2016-11-02" version="1">MSADLFAAFLAERVAPEDPLESLTQHKTSPREDHVHCSPSTPIKSTITRAQQPTDPSLLLNRSDDGADILFDADEAALDDDEFGDFETRAKPSIDEADLTSGLDPSQSAHPGTVTSVSPRVPDLLDMNDGIPEAAGAADKVSWPESAFHRQSAIPRRSTGSANATETDAWGDFEQTASQDTPAVDDLAFGSRRKSQTVKEEITAHSADEEWEPFDEEPRSDGSYATGAPKLPGSLPSEPVRATPGQPRSLIVLDRPSNVPPPSSLLPLLSAVFQSIRRGNVDTDTPKSDLASQVLLAFRTASRIIAGRTLRWKRDSLLAQSVRIGQAGKSGGMKLVAVNKSETSKEEKEVEDMIQDWSNYIHEFNSIISRAGLPPSRMRLSPRIPLKAGKHPNSSDSSKQCALCGLKRTERLSEVDTDVDDLFGEFWVEHWGHRDCCDFWYSYKAMLGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6F8</accession>
    <name>A0A1C1C6F8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NIP7</name>
        <name evidence="9" type="ORF">CLCR_00719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6F8"/>
    <dbReference type="STRING" id="86049.A0A1C1C6F8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00719"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01060"/>
    <dbReference type="eggNOG" id="KOG3492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="99"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="186" mass="20815" checksum="24724038114E0D5D" modified="2016-11-02" version="1">MRPLTDTETQTLFTKLANYTGRSLTQLIAPSDSSKDDRHVFRLHESRVYYVRLSLANLATSIARDNLLSLGTCIGKFTKTGKFRLHITALDVIAPHARYKLWIKPNGEMPFLYGGHVLKAHVGRWSEDCPEHSGVVVFAMDDTPLGFGVTAKSTAEARKLDPTNIVAFRQGDVGEYLREEDTLFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6Q9</accession>
    <name>A0A1C1C6Q9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6Q9"/>
    <dbReference type="STRING" id="86049.A0A1C1C6Q9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00659"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01092"/>
    <dbReference type="eggNOG" id="KOG2936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="12"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="325" mass="36318" checksum="C31BBD8F7BA2B256" modified="2016-11-02" version="1">MLHNPNNWHWVTKDAGPWAKDYLDTQVKQVSAEENGVSAKVTKLISMDGDVEVSQRKGKVISIFDVSLQLEYEGKTDDGTDVSGSIRVPECAYDTEADDYVFDIDIYSEKKEKQPVKDLVRSKLVPQLRTVFSKFGPALIEEHGKDLQHAPGSNPSSGFATPTWHPEKERKPLSPAPTTTSTSGKSSVNTTTVTATDEFRTTADELYQTFTDPQRLAAFTRAPPRVFEGAKPGGKFAIFDGNVSGEFVELNPPKKLVQTWRLAQWPEGHVSTQEIVFDQNDVDRVTNMRVTWTGVPVGQEEVVQRNWEGYYVRSIKQTFGFGTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C723</accession>
    <name>A0A1C1C723_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair protein MSH5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MutS protein homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_06005</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C723"/>
    <dbReference type="STRING" id="86049.A0A1C1C723"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06005"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06965"/>
    <dbReference type="eggNOG" id="KOG0221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001067">
        <property type="entry name" value="DNA mismatch repair protein MSH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT44269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="377" mass="41094" checksum="074D165986281D9E" modified="2016-11-02" version="1">MYGLDHEVGDIYSAICEMEVEIAHNLAQSILLDEELLIAASDLCGELDSLLAFSHVAYHYKLTRPKITEENVINIEGGRHLLQEMAVPSFVANDTYLIGGNGQDDTHGPNMLLLTGPNYSGKSVYQKQVALAVYMAQIGSFLPADAATIGITDKILTRITTRETVSKVHSAFMIDMQQIAMALNSCTRRSLVVVDEFGKGTDTCDGAGLAAGVFRHLLSLGANSPKTLVATHFHEIFDLGLFDNCPNLSLAHMEVRVDARDEQTAEEHGSEITYLYNLRAGRSDLSYGTQCAALNGVPVEVVERAVELARLAQQGEDLVAVCSALTKEAKEELQHAQNSAQKFVDQDFERAWTKDELVVTLDAMLEVVTVTETSLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7E8</accession>
    <name>A0A1C1C7E8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WW domain-containing oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Wwox</name>
        <name evidence="4" type="ORF">CLCR_06081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7E8"/>
    <dbReference type="STRING" id="86049.A0A1C1C7E8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06081"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07137"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="314" mass="34250" checksum="B75FEAF2BC528BAF" modified="2016-11-02" version="1">MAFGFETTGDEVVEAFKDRVTGQTCPTPGGIGAETALSLAKADPKCLILAGRSQQKIQPLVDQIHQQKPHVEVSFVQLDLASLSSVRKSIDGIKSVLAGGKIDVLILNAAIMACPYALTVDGFESQFGTNHLGHFLFGNLLLREDLVRSRIVVVSSSASERKADYAFAPLKDISYDHGKVYDPVQAYTFSKSCNNLYACRLARVLKPKGIAVFSLNPGSIITNLQGYMTEEVRNLAIESAKRENPEFEIPVRKTLQQGASTQLCAALDPSLEPDSGAYLDHCQVKKPAVHDGHEAFVDQVWELSEQLVGEKFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7L0</accession>
    <name>A0A1C1C7L0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SNARE domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_06165</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7L0"/>
    <dbReference type="STRING" id="86049.A0A1C1C7L0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06165"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07182"/>
    <dbReference type="eggNOG" id="ENOG502RZK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244190at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15859">
        <property type="entry name" value="SNARE_SYN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000060">
        <property type="entry name" value="SNARE complex subunit (Syn8)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="202"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT44500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="292" mass="32240" checksum="B720841A8DE7EE9D" modified="2016-11-02" version="1">MSNPSQLLLLADHIKLSLLERQRALSLNLDPNPSQDSNIARSLESFREGIESLSSRAPADESLPQLRSQYNDLSRQFQGESSTTADDTLSSPNDPTLKEDFARAKTRTSSDAARRQQKTSNLRRQDAGAAPAVAAAAAAAGAKNVRFRDNPSQESLDDDEDEATRAALFPARYTDAEDHDSRARTPDPTGDMSNQQIHAYHQQIIAEQDEQLDRLGESIGRQRQLAMQVGDELEGQIGLLDEVDRGVDRHQGRLDGAKRRLKGVSQRAKDNWGITTIIVLIVILVLLIILLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7L8</accession>
    <name>A0A1C1C7L8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inorganic phosphate transport protein PHO88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PHO88</name>
        <name evidence="3" type="ORF">CLCR_06282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7L8"/>
    <dbReference type="STRING" id="86049.A0A1C1C7L8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06282"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07134"/>
    <dbReference type="eggNOG" id="KOG4554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="191" mass="21093" checksum="88E693116933A0AB" modified="2016-11-02" version="1">MNFMNPQVTNLVIILGMMQVSKRIPFDDPQVLTGVRILYVVSNLLIFGLYYYIGMKIKAKRDLTTLKYVEPAPVGSGEEPKLVTTTIQEYDQNQLTAAYKAQLMGVGMMAFMHIYLKYTNPLLIQSIIPVKGAFESNLVKVHIFGKPAVGELKRPWKASGGMMGMGQGETKSDKASIEAAERAGRGGAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7Y4</accession>
    <name>A0A1C1C7Y4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="12">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SmE</name>
        <name evidence="14" type="ORF">CLCR_06429</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7Y4"/>
    <dbReference type="STRING" id="86049.A0A1C1C7Y4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06429"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07248"/>
    <dbReference type="eggNOG" id="KOG1774">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990935">
        <property type="term" value="F:splicing factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000031">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT44568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="94" mass="10541" checksum="E392E5E90FEDC4B5" modified="2016-11-02" version="1">MTGRGGGGGRKTLLAPIHFIFSLLQKRSTVSIWLYENLLTRIEGKIRGFDEFMNLVIDDAVEVQLATKDTPQKRRQLGQILLKGDNVSLIQSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C859</accession>
    <name>A0A1C1C859_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_05927</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C859"/>
    <dbReference type="STRING" id="86049.A0A1C1C859"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05927"/>
    <dbReference type="OrthoDB" id="4157664at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF57">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="109"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="425" mass="47641" checksum="B3FD9BD00276E2A6" modified="2016-11-02" version="1">MGKLFRIMDMAAFEVELQHFWETPEKASPGWMAQLLLVMSLGCDSLNTMDGHFAASHGHLPNQFLDQAAVLLHQTPFMFRPDVGTIQTLCLMVLAKLMIRKSCFEEDASWCLTGMIKRLAMSINLHLDQPGIPSTYLESGVRRGLWTTILYLDLHLSVLSGLPSLAEPLRTSSAPSGGLGFGDGPHRLPDDSTPRTTSHASYGEEVYQTVFSRVLPLAHEVALAARSIDLPYETAVRLDENVRKVLREVRELSAESASPARACHDDYLVLPWEATTYLDTLFRRLLLELHRRFAYEPQAAIHHAVSHWSTLDCAAAMLVLQRSICEKSESTAGQWLIGIFRSDFFVAGLTVSVYLIQNSSQLDSPTLPGGYALKTLLDTLRSCRDLWARGKNVWPCEFQKFRFFDQVIASLDQCTVVSHAYRNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8C9</accession>
    <name>A0A1C1C8C9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8C9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06156"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07388"/>
    <dbReference type="OrthoDB" id="4157359at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="295" mass="33135" checksum="0EC79F2079CB567D" modified="2016-11-02" version="1">MIPHRNLMPCGVGVPTLATAQHSHIRQEADYIHERINAATALHRKLSSEIRRAERRLDKARQDKWPDEPNTAISITSLKKSIRKQRSRLNRCARNLAAFEDRLAAITLQMQALQQRQWRHSAPQLYGLEDACPERFASAPCRHDWSASTPLHILQPPTPALGAGVLETQMQGQMQSQHHPVVGYLPRTPVLRPVQVPRLVETEVFQQSAGPMHVFEGVEISPTGTVSPYDLSPPRGFPAAQRIDLADAVSNLRISQAREPDQAPRLGVDLSQRLRLLDHESAALRLQRLARKGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8K5</accession>
    <name>A0A1C1C8K5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box and WD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8K5"/>
    <dbReference type="STRING" id="86049.A0A1C1C8K5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05395"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07457"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF2">
        <property type="entry name" value="F-BOX AND WD DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11400)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1086" mass="117306" checksum="1FD4F11C1FBF071B" modified="2016-11-02" version="1">MQSAPPEVPQNATSVDPSQQTPSPPAQHGLSHNGQQASGGTLPRSSPREPAPTLDDTSDSISVSSGGTQRGRSSHAGRLSRQHSSSQEGSPGSRIDEYERAFTKYRRPSDEMIFQIVPSAKDKTSTVSIEGFPNGAEALEVASGKTARDSVSDIEKTQRRSFTRLSALSSWRSEYILRTRLLRSLGRGRPAIEAISRSGAARHASSAAAAAVTTYASGLYYPVSHLHATFGVGLNKKQPMFMHGAVEQGGVTVSDPANGKPGTWGTTDFDAFRHFADQFPGELPYGLGPGNVVGMPNVMDISQPYGKVYGEALPGGRLFYTSTSEQRGRFVSISSTADHARGIPEASMINSAICSVWIAKSESVLKATDGLFGFLAGFSNGVLGAYALGVSPVLDRRYEKGEPTAKWVLCPGVPIIAICVDEKMSVRRLANHRIWAAVLNALGEVFYLTDAPTRPHFTGKASTDDLERLAWQTGRSVQWSLVEATRRKAKPDPFGTAKVDGSYSPRSSSDMSGLSVDQIIAETKEVEQFLRHKPRHFQNLCDGWDMQRRLIVDFAGDDHRNAGESVFVIDCGLYGDRVAAIRRFTRSQTKIPADFDLDSWPTIESTMKRSSLFGGSPVQHSPYASPALGSVPRSRTSSQDDSADSKFRETWFISSFLFAEHRNVHISSLASDDSEFAVLNVNEDPLLGMSGGSNASSPLSSPMGAASALSSTSEIPGRRARLFGIGTTSGVVMLWDMRAGLSPSDDVVNTIQPVRIIYTKSPQISSLALTSLYVVHGGNEGLVQAWDPLASSNEPIRTLNSRFSDRARRRIAQAEASTHGVGNNFYAAGAIVLDPDPTALRGMVSLGSYVRYWSYSSTAADAYKSRKRGQLHRRSERGSNSTPAGLKVSATGRGLINDYISNERLEIERDRVAREKERDRLTGRFGTNLLGEGASEEEMLAYATMLSEEAFSNEEKKRKEDYGSSSIASPSPPPGRTDTDADLEEAIRLSLLDSEPVSSSPAADEFNIPIRYAKSSRHGTPSKSAKAGSSKAHASAQEVDDLEFALQLSLAEEQSRLVMDTDFPALSPASSNGSDSGRGKGKSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8R3</accession>
    <name>A0A1C1C8R3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8R3"/>
    <dbReference type="STRING" id="86049.A0A1C1C8R3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06191"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07512"/>
    <dbReference type="eggNOG" id="KOG4690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10064411at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="145"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="278" mass="31161" checksum="1CEC1B31A2AE5496" modified="2016-11-02" version="1">MKTRSSLISAALRSRWTCVACLRQQQRLQSRKLSTPVFQSAHLPQESRDKALRRSVVGSSRPLHTSRPLGREADQQRQAVPLGDFYTDILANPTPKKSKEETSLPTFVQSGDKSKEERAKMLFGSIEGSGYERHTYDKPDNTWRTINGVPVPPRPAEPDNCCMSGCVHCVWDDYRDDIESWASRVAEAQAKSPKKRAHGRTPKIEMSRPEVDNASGSMDDDGGGSEGLWTTPSSSADEDDVLFQGIPVGIRHFMATEKRIKERRRAKREKGASVDDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9H2</accession>
    <name>A0A1C1C9H2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA biogenesis protein RRP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ribosomal RNA-processing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rrp5</name>
        <name evidence="13" type="ORF">CLCR_05339</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9H2"/>
    <dbReference type="STRING" id="86049.A0A1C1C9H2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05339"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07775"/>
    <dbReference type="eggNOG" id="KOG1070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05702">
        <property type="entry name" value="S1_Rrp5_repeat_hs11_sc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05703">
        <property type="entry name" value="S1_Rrp5_repeat_hs12_sc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05697">
        <property type="entry name" value="S1_Rrp5_repeat_hs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05698">
        <property type="entry name" value="S1_Rrp5_repeat_hs6_sc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05706">
        <property type="entry name" value="S1_Rrp5_repeat_sc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05707">
        <property type="entry name" value="S1_Rrp5_repeat_sc11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000103">
        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000155">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000159">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000196">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000279">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057301">
        <property type="entry name" value="Rrp5_OB_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057302">
        <property type="entry name" value="Rrp5_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048058">
        <property type="entry name" value="Rrp5_S1_rpt_hs11_sc8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24685">
        <property type="entry name" value="OB_RRP5_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="150"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="268"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="451"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="542"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="636"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="820"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="928"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1036"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1123"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1217"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1306"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="1627"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1420"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1451"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1489"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1452"/>
            <end position="1464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT45108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1814" mass="199794" checksum="8A4D527E2037556E" modified="2016-11-02" version="1">MASAKRKPEAAPSRQPSKRPKTDPSSKAEAPVQEQKRDQKPKQASILMKEQPAFPRGGASLLTPLERKQIRAKAARDADREQKSTEDLFGGGDRALDTESDEDEKAKPQIEPKRRERQRTKGKKKPDSAAVSTKAEVQIGGLSYKRITTASLILGQVTSISARTLTVALPNNLVGYVPLTAISPQLSDKIQDLLEKNDDEGNNSGDEEEEDDDISLTNYFRLGQYLRVAVTSTEQERQGQTLARKRIELSVEPALTNAGLNRQNLAVGATVQASVSSVEDHGLVVDVSLEDDHVRGFVPSKQLPSGRSLSDIKTGAVLLCHVLDASPNNKVVKLSADLSKSVVLKSAPSVDTFLPGAKAEILISTMTEAGLTGKIMGMLDVTADVIHSGSFRDREAFLAKFQVGQRIPGRLICNFPLSDNRKLGFSVLEHILDLSDIPESTGTESGRLALSSTIESASVIHVEPGLGVYLQLNEQNVGFAHLSRLADKKLDAISELSGSFKLGSEHKARILEFNPVDNLYVVSLQESILQQAFLRYEDVPLGAVVKGTIEKLVIGESGVEGLLVMLAEGITGFVPKLHLSNVKLDHPEKKFRAGQTVTARVLTSNPARRRLRLTLKKALVTSDQKAWLRFEDIEVGDSTVGTLAKVDPLGAVVRFFGSVKGFLPVSEMSEAYIKDARDHFRVGQVVSVSALSINATEKRMTLSCRDINRSNASIESSLSRLLPGTITNGTVFEKSENDILLRLEENDAIARLTLDHVADGSLKKRQSAFSKIRVNQTLESILILQVQAKRRIVLISNKASLVSATRTGTFLKSFEQLQLGAVVTGYVKNITEDGVFVGFAAGITGLIPRSQVPVEKEDEENFGMTDLQPVTARVLNIEYKGAAPRFWLTMREDGSVTKSEGPPTEPASFKLVDPVDASLTVVNDLSVGMKTKARVISVKDTQINVELAKDVQGRIDVSEVFDDWKDIKDRKKPLKPFYPQLELTVRVLGAHDTRNHRFLPLTHRNGKNTVFELTCKPSSIASEKLPQLALQDMTVGSSHVAFINNITDECVWVNISPTVRGRIRTIDIADDLSLAANLPRNFPLGSAVRVRVLAVDPEKGHLDLTARSDGTAGSLDFANVTPGLVLPGRVTKVTDRNIFVQLSEQVAGSVELVDMADNYDEANPAKYQKNDIIRVSVVGVDVPNKRVSLSTRPSKVLSSSMKVTDREIDSVDRVAVNDIVRGFVKNVSDQGVFVTLGRGVVGFVRISNLSDSYLKEWKDHFQRDQLVRGRIIMVDEASGQIQMSLKESALKPDFKVPITFNVLKVGDIVTGQVVNVQPFGVFILVDNSEKIRGLCHRSEIAEQRVEDASKLFAVGDKVKAKVLKLDPATRKVNFGMKASYFTDPTEEEAESDADSDSQGGAMLDAEMEDAEADINLFEDEEDEPQSGDDDSHVEGDDEDSDMVDIQIHPDINDTEDEDEDEDEDGATHVSAAASKSMALSAGGFDWTGLLPAPSPSSKRLAEAPDSDADSPKKKHKKKKNQPTMDVDRTADLDVDGPQSADDFERLLLAEPDNSVLWLRYMAFHLDLGDVDAARAIGERALRTIPVGLEDEKFNVWVALLNLEVHFGDDESVEEETFRRACEVNDQQEMHARLASIYIKEGKFAKATDVFERMIKKFARDPKVWVNYAAFLLDKMGDDDAGREKAHALHARALQTLPKFTHFETTKSFARLEFTSAHGLPERGRTLFEGLIASFPKRVDLFDVLLDLEMNVTKDDEQVRATFERIFSLKLKPKQAKSFFKRWDRFETARGDERRVEAVKARAAAWVRENAKSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9Y5</accession>
    <name>A0A1C1C9Y5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9Y5"/>
    <dbReference type="STRING" id="86049.A0A1C1C9Y5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05410"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07922"/>
    <dbReference type="eggNOG" id="ENOG502S2K4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66726at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="665"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="969"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1047" mass="114616" checksum="A233919ECCD2FE38" modified="2016-11-02" version="1">MVSVESTAAQAASTFTQVQGPITASPSLLNLTAFKTAAADVTSSFTLPSAEQLLRFPLRFASLIDRAVLFIWHQVFVESFGINIFTRGGPPLAQGAGGAQVMAEAAAQPAVAQAVAEAGAESWAAFFAEAFQASTFKSYWGMLHYLTSRWAFTCFAMALILNRIGVYGASRQRIQLTWTKRLALRILPILLFTSQIHSLLQAIRCQTSPDYSLYRHGDNNKYSLLDWSTDGGPLHTFTSTLLFQSTDADACAAVGMSRPSPDIRAPFGSFSLLWPSFLRLSLSHVVDSLSCSLQQIPTMTEVGMSVFEHSLAFAEAETMISHTLGLGYFSTVKASSSGNTTASGFSQADSSPTIPASGTILALADATAALTGPHILDRVNVPVEVLLVTLLSCCNSLSSHVIAVLGKQRQWRLVNTAIWGMAFMGSFVWGLFTTSVMVRSGENGDNRPVSSLLHFPTVAIVGFLPHMAILVGVAVCLVIYLVALTLTAISLGTNPHIPQPSSLKERFAIAHDNLQAAVQTRGINIRWYEDFYTALLRVGFAALTAASEAVFLNEGRAVEVRQFTWLEEDRLDEFDSAMREMGPFQGGGTLQNGQQFQILEEYGLPPSSPGGTDKGGVWESGFGKERKFDKKENELEGKDSFVYPTPRSGGVGAVQRTTRFYLLMIYLRGIMFLSAGYIGFGVGVLLDTIGITARPRWLRRLVGRSLKKMNAERNATTTGALDFWVLTEDGKLTIPSSDEVDIEPEMRKRLMTEFSADRIDELLDAKLYDWWKSGGWFGTKDESGEYQPSHADDLDDVTSVVSMSTDADSSVHEDEWESEPEGTRTPTQTSSGQMWSFSHIQTRESTPEPFPDSPLDAMTLARLLNPKDSASREEARILSSHLLASASADSPGIMTRSRYRRELEAERARILLAGRTPGLDAKPHHHDHMGKVPAVSLYTEPETKGPRPLTSIEEAEVLESLILERRKKHTSAPPLRIPDATETDDDSSRQLGPPCVVCQVSSRTIIAWPCRCLCVCEDCRVSLALNNFGNCVTCRRAVQGFVRLYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA46</accession>
    <name>A0A1C1CA46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_06088</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA46"/>
    <dbReference type="STRING" id="86049.A0A1C1CA46"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06088"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07953"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF16">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="65"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT45312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="312" mass="33460" checksum="658588E2356E8DD3" modified="2016-11-02" version="1">MSDKPQAPPTAYPASELEPQNQEGGKGLDSKMTPSANWTQLEFWDDEGKAPYLKDYEGRGLLKDKAVIITGGDSGIGRAVAVLMAREGADVTFVYLPEEEEDAQWTKAEIEKAGRQAQPLALDVTKEENCKKIIDAHMSKFGKLSVLVNNAAMQEMCEDISNIDLAVTEKTFRTNILAMFAMAKYAVPHMKRGSSIVNSSSVAAYMSNPTLLDYASTKGSIVTFTRGLAQQLAPKGIRVNAVAPGIIWTPLQPATKGNPPEAMSALGVSQAPLQRPGMPVEVATAYVHLASPLGSYCTGETIHVTGGLEMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA56</accession>
    <name>A0A1C1CA56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA56"/>
    <dbReference type="STRING" id="86049.A0A1C1CA56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05726"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08035"/>
    <dbReference type="OrthoDB" id="5431222at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="522" mass="58974" checksum="9525B328DB2BAF7D" modified="2016-11-02" version="1">MASGQARSSTDYAATAFGGSQPLTKDNGKNERCDGDSYNGDHQRFYHDQPAQPDWQPAPNSPPPRHHGMRIRGAAGLEYDIRFPGGAERGEHHRYISGARSTHHAQYDPNHTDHSRIVPSGCSPRARSSSNGDRQDLDRLLSDQSRTIQRKDGQINEQQKLINKLTSEKKTLAASIEDLRMIKDSLIRRLNEKNLEFQRLDFHDAEASHRKDDLTAAQDRDLQFSNRYVKDLLDQTHNLREVPMPPPREGFWRSCSTEDPSGIGEADSYADSDKFLSALDFPDDSAFQGADLATPVERRLQALGATMDENDLMESQQPVIVSKHLRNCKDSEKSSWSRPVAQTVLWPKVKDDPAFADIGDGPPVSFDVLWHRIRDITSSHVADDDQYDSHSPTFDERYDPQEHPLLSLSERGLSNKEEEQLAVPAGPNHLAPARSHMRHKGHGRPRSRSPGYRGHRDQRPNYRQRRYEGSNPGPPSTDRDRDRHRYEIWKPTAKPEDTQGAERQRKEKAAAAKAGGGICRNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAE6</accession>
    <name>A0A1C1CAE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_05763</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAE6"/>
    <dbReference type="STRING" id="86049.A0A1C1CAE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05763"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08066"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650676" evidence="8">
        <location>
            <begin position="33"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT45438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="508" mass="56903" checksum="53C277E86DF42C51" modified="2016-11-02" version="1">MISGPFLLTALFLFSILALRLLLNYFAPGLQSIPGPVLARFSDLWRFIDACKGNHQQTMSELHSEYGPVVRIGPNFVSVADPAAVELILGLKANLDKTDSVNPMINAHEGEYLPMLISAKNSKLHARLKRPIAGAYSMSTLLSFENVVNDCSDKLMRRLREEFVDGKSHGRVCPLHEWLHFFTFDFIGRATFGKEFGFMDAGTDINNMIGTLDLQFLYIGAVGSMPWIDRLLLKNPLLLALIKTPNHLVDFTAQRIRHRLEGREKGDTSGYDFLSRFLDAQKQHPDVVTDIQLAAYTNTNILAASDTTSTALTAIIMCILQHRDVYDKLQAEIDASNVSFPVSYTAAQSLPYLDAVIKETLRFFPTTGIDLERTVGASGLSLPTGQSLPPGTIVGMNPWPLHRDRSVFGDDADKFVPERWLRTETESKAAHDERVRNMQRVFLTFGYGPRACLGKHIAYLEIYKLIPILVGNFDLSLVHPDRPPKTWTGVAVKILDLDVHIRERHRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAI1</accession>
    <name>A0A1C1CAI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein GstA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gstA</name>
        <name evidence="4" type="ORF">CLCR_01708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAI1"/>
    <dbReference type="STRING" id="86049.A0A1C1CAI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01708"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03407"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF2">
        <property type="entry name" value="HYPOTHETICAL GLUTATHIONE S-TRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="97"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="221" mass="24082" checksum="7EE86A8183500B6C" modified="2016-11-02" version="1">MAPRLYCCLASGNCYKIRLLGSLLDIDLEEVEVDLFANAQKSPDFLAINAKGELPTLVDGDDKVFTDSSAIMVYLAGTRPDRGSQTTMAPSSYWSSDVVEQAQIVDWLAFAACDIHVGLAKARAIVAFDWPPGTSEKTLDEARRKGVASLQVLEQRLRRETWLALGRPTIADIAVYVYVALAPMGGVSLEPFPAVKAWLARVAQLPGYIGPDGLDQPLQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAV0</accession>
    <name>A0A1C1CAV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP synthase subunit beta</fullName>
            <ecNumber evidence="14">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_01440</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="14"/>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAV0"/>
    <dbReference type="STRING" id="86049.A0A1C1CAV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01440"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03506"/>
    <dbReference type="eggNOG" id="KOG1350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="187"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT45597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="518" mass="55874" checksum="D379D0087AA9359D" modified="2016-11-02" version="1">MLKSGIARSLGRSAFARPSITRRAFEPIRKSFAPAIAQRWASTESSKEGKIHQVIGAVVDVKFDTEQLPAILNALEIDNNGTRLVLEVAQHLGENVVRCIAMDGTEGLVRGHKAIDTGAPISIPVGPGTLGRIMNVTGDPIDERGPIKATKRAPIHADPPEFVEQATSAEVLVTGIKVVDLLAPYARGGKIGLFGGAGVGKTVFIQELINNIAKAHGGYSVFTGVGERTREGNDLYHEMQETSVIQLDGESKVALVFGQMNEPPGARARVALTGLTVAEYFRDSEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLAVDMGLMQERITTTQKGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRGISELGIYPAVDPLDSKSRMLDPRVVGQEHYDTASRVQQMLQEYKSLQDIIAILGMDELSEADKLTVERARKLQRFLSQPFTVAQVFTGIEGKLVDLKDTISSFQKIINGEGDDLPEGAFYMVGDFESARAKGEKILAELEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB64</accession>
    <name>A0A1C1CB64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB64"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01729"/>
    <dbReference type="OrthoDB" id="5350673at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="134" mass="14580" checksum="D102BCFEF28554B1" modified="2016-11-02" version="1">MVSNHAHVVSPLEKKSGLILSSCARPELFNVAFTPTSPPSLDILFTLAILLVVWVYASPLPDLAVASLDDMLHKLKMFRGCKKLFETHGGAIIDEPIIRVAEFNKHNIGLSSPASQAFSYLRSTPVDALDLTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB99</accession>
    <name>A0A1C1CB99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB99"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01772"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="82" mass="9063" checksum="8BAB9E0A25A7E2FD" modified="2016-11-02" version="1">MVKLRERAGCTRDGQATRHFRGPLPTTPEHERHGKARRNGAAEVSGVRIDDAQLWYPPQPTYLVTDISVGLLGMHPNHLAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBR7</accession>
    <name>A0A1C1CBR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_00514</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBR7"/>
    <dbReference type="STRING" id="86049.A0A1C1CBR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00514"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10045"/>
    <dbReference type="eggNOG" id="KOG0530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT45964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="238" mass="26564" checksum="46DD6D485F46425A" modified="2016-11-02" version="1">MSLLATLPPTEPAFLAHILSFDAKNYHVWTYRQWLCRRFPDPLLNTDVELRAVDALIQDDVRNNSAWNHRYFVVFGVDELRAIEVEVKASDGGAGGGRGGGIRKEVLASGTLVVDLDVVDREVNYAKDHIAWAPQNASAWNYLRGVLTRAGIPLTEMRVFCEGFVGGKGADLMSGGSSDTPGSSVRSSHAIDWLADIYRMEGDVHRSKECLDALASKWDPIRRKYWEFRARQLEGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBY3</accession>
    <name>A0A1C1CBY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial distribution and morphology protein 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MDM31</name>
        <name evidence="12" type="ORF">CLCR_00390</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBY3"/>
    <dbReference type="STRING" id="86049.A0A1C1CBY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00390"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10369"/>
    <dbReference type="eggNOG" id="ENOG502QQJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="136"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT46053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="718" mass="80882" checksum="FAEEDCC9E599CB97" modified="2016-11-02" version="1">MTEALFRGICDVSRIAAIAPRATRVVQRHPPCLDRSFNYHVPRRISTTNAPDNTLGRLGQSVWPYSRQRAAQEQSCHPRVSQPQSRLIPSRPNFLPARNTYTCNPGTLGLRRHHGELGGCLRGRFGSIQHRDLHTTRVLRDSSDKERDGHYRQDGAENASKPAPSDTGSKAAPGHHQAHPGSFYDRLHMPQFHRPTKQELLAAATGFWSRLKVHFKWFTIKSSRPFNMDEIVGFISWIALGHVIWFVIGTTTFVSLAILAINTVFAQETLAGWIGNYLTKSSGLHVVFESAIVPKWGDGVITFKNVFVSRRPGRTKSNVSKGSPEAAAQASSTEDPVPPEEQNYTQFDITIGEINVTLSFNKWWNSKGPLQNVEVKHVRGVVDRTHVFATGEQVDPKSYRHEHNPGDFEIESFKIEDLLLTVLQPEGFRPFPVSIYTADLPRLRKQWLFYDFLSANSITGEFDKSLFTIHPRQTHSYTGVQLNDPENPSNEPWKKQSRIRIDGINIDHINRGAAGPLSWIHEGNVDIVADIMIPNDGDDSVIKVMTDFYERMEATLTSNKHLEQQHLDEYVSGDEPVAVGGVVVPSPGAQAVRDEDKRFLVMDLRIHLNDVRAVVPLFTRDLSYINNALIRPIVAYINSRRTFIPINCRVVKRLSDFDGSWTVFDSGLMDDLSAEVYDAFARDVTDEQARLRRFKKVGLWSLQLAVQAIFLGMAGNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC61</accession>
    <name>A0A1C1CC61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_01202</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="6">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="6"/>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC61"/>
    <dbReference type="STRING" id="86049.A0A1C1CC61"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01202"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09385"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="149"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT46130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="435" mass="46032" checksum="9837DAE0BC4CFFCF" modified="2016-11-02" version="1">MPALSPTMTAGNIGAWQKKAGDTLAPGDVLVEIETDKAQMDFEFQEEGVLAKILKETGEKDVAVGNPIAIMVEEGTDISEFESFTLDDAGGEKAPPKEQPKEESSEASEAPDSGSDTAPPSGAKEPAPKAEEADTTGEKLQSVLDREPSLSPAARKLALEKGVPIKSIKGTGPGGRITLSDIEKYKPAAGAAPAAAAGPTYEDIPASSMRKTIATRLRESMNQNPHYFVSTTLSVTKLLKLREALNAASDGKYKLSVNDFLIKACAIACKKVPAVNSSWREEGGQAIIRQHNTVDVSVAVATPVGLMTPIVKNADSIGLSAISGAVKDLGKRARDGKLKPEEYQGGTFTISNMGMNPAVERFTAVINPPQAAILAVGTTRKVAIPVETEEGTLTEWDDQIIVTGSFDHKVVDGAVGGEWIRELKKVVENPLEMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC73</accession>
    <name>A0A1C1CC73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium/hydrogen exchanger family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_01117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC73"/>
    <dbReference type="STRING" id="86049.A0A1C1CC73"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01117"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03430"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF3">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="6">
        <location>
            <begin position="27"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT46140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="598" mass="65775" checksum="E3F0CCD197E097E8" modified="2016-11-02" version="1">MPSLDVSELNIVIAVLGFFILSYGFLSVKIKQVWYLGEALPAVAFGVVLGPIAAKFLDATRWASAVEGQQSAITLGVARIVIGVQLVIAGFQLPAKYQLQRWKEMLLLLILIMTIMWLCTTACLMATVPKITLLAGLVIGSCVTCTDPILSQAIAKGPFADKYVRRPLREIISSEAGANDGFGFPFLMLAVYLIRHAEYPGLEQEMADHTAALSAKEAGIQELAQNVTEGAAHLLARAVLVAREEGGEEVGRLGGGVGTALGQWALETWLYIVLMSVAYGAVCGFGSMFLTRTALRRNWIDTESYLLWPTALGLFLVGTCGALGTDDLLACFVAGNALNWDGQYLAETEKRHDEVNSCVDVLLNFGGFMYIGTIIPWSDFNDPNGTGLTYPRLIGLGVLVLIFRRIPAIFATYKLFPEVCKDWKEALFMGYFGPIGIGAVFYVEHTKHLFPESGEALTVEENVLTRAMVPVVYWLVLFSIVVHGLSIPALNAFLKWRGVAPVEDEHGPIEVTALSEHEPVPKNARRSSDPKRRSFVVNNRFSRSDITYLAGPVVPQNWPQQTYIDDPNERQGYYQPAIRERKIMFSTAPRAIEKDNMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCC6</accession>
    <name>A0A1C1CCC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell division control protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CDC3</name>
        <name evidence="6" type="ORF">CLCR_01160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCC6"/>
    <dbReference type="STRING" id="86049.A0A1C1CCC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01160"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09387"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990317">
        <property type="term" value="C:Gin4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001400">
        <property type="term" value="C:mating projection base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031105">
        <property type="term" value="C:septin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032160">
        <property type="term" value="C:septin filament array"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031107">
        <property type="term" value="P:septin ring disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="135"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="474"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="511" mass="57974" checksum="C13161226B239080" modified="2016-11-02" version="1">MTAKEKSNPGPSTALNPPHVQSPHGEPKSLSFHTQVTSADTQFENMTDSNETPAAVANGVRSSPSPSIPNGKPTSPFVKESNPMGANAAQTVSSKDPKAAAAAANDMRNVVRRKLTGYVGFANLPNQWHRKSVRKGFNFNVMVVGESGLGKSTLINTLFNTSLYPPRERKGPSLDIIPKTVSIQSISADIEENGVRLRLTVVDTPGFGDFVNNDDSWRPIVENIEQRFDAYLEAENKVNRMNIVDNRVHACVYFIQPTGHSLKPLDIEVMRRLHTKVNLIPVIAKADTLTDEEVAAFKQRILADIQHHSIQIFEGPRYELDDEETIAENQEIMSKVPFAVVGANYEVTNPEGRKVRGRRYPWGIIEVDNEDHCDFVKLRQMLIRTHMEELKEHTNNVLYENYRSDKLIQMGVSQDPSVFKEVNPAVKQEEERTLHEQKLAKMEAEMKMVFQQKVQEKESKLQQSEEELFARHREMKEQLERQRAELEEKKSRIEQGRPIEKEGKRKGFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD85</accession>
    <name>A0A1C1CD85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="8">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="8">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Translation initiation factor eIF3, p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">prt1</name>
        <name evidence="8" type="synonym">PRT1</name>
        <name evidence="12" type="ORF">CLCR_01836</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD85"/>
    <dbReference type="STRING" id="86049.A0A1C1CD85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01836"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01223"/>
    <dbReference type="eggNOG" id="KOG2314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000419">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000235">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="39"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="646"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT46494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="745" mass="85653" checksum="B59351781E95B91E" modified="2016-11-02" version="1">MAPGFDQLSDHDYDDDLENIDFSDLKERYDVRMEEGLDTFVVIDGLPLVNQEQKAKLIKFLLKRLNSVGRIKDGEESIFMPMNDEGMSEGFAFVEYQTPEQAIAATKQLHGQPLDKRHTLAVNKLTDIEKYGREGRIDEEYHPPEIEPFADREHLRSWLFDPQARDQFVMFRGDNVGVFWNNKKEPPEPIVDRKHWTQLFVSWSPHGTYLASIHQQGVQLWGGSSFKRIRQFPHPFVSLIEFSPGESYITTWSNQPIVVEEGKGPLTIDEEGKHIIIWDIETGKPLRAFHAHDLTPPPGTDAAALPPKAKVQWPAFKWSADEKYVARMKPHESISIYELPRMNLLDKTSIKAEGIMDFEWSPAITQREGIKTYESLLCYWTPEIGSKPASVALMSVPSKEIVRTRNLFNVTDAKLHWQSEGKFICVKVDRHSKSKKSVGTNLEIFRIREKGVPVEVVDSLKDTVINFAWEPKGDRFVLITAGEAVAGSNVLPKTAVSFFAPEKVKGPGIGGFKLVKTFDKKNSNGIYWSPKGRFVVVATVSVQQHSDLDFYDMDYEGERPENDTAAHLNANLMLMNSEDHYGVTDVDWDPTGRYVTTSASVWTHQMENGYRIWTFYGALLAEQPTEKFKQLLWRPRPPTLLSKEEQRTIRRNLREYSKEFEELDKEMEEGANQAVIDARRRLYMEWYSWVQHEKELLAEEREQLGLKDPEEELALQRTKSVEGEAEKVVEEVIEEVLDETEEIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFQ1</accession>
    <name>A0A1C1CFQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02264"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02083"/>
    <dbReference type="eggNOG" id="ENOG502T5CC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4160512at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="735"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="839" mass="90511" checksum="0955CAB8C05C0E8B" modified="2016-11-02" version="1">MPTMAPTAHPSDDFDMAKLQKTLKQRQRHAVRNSAHVAKLTPAEIRSLNNGALASRTGSQSSAKSTSSPARSRRSTNATPPATPDEPPAYQPQAHRNPVSRNNSFNIPTPPHTPSGHRRSSQSSTHGHHHHGHGFSHGHASGVIHAPRPRGSVQAAFMSGNGISSRPSSSGSSTYRGLPTYRGPEVTRTGSVNMLQYPSHQIVNNPLSYFSRPRQSQISTSPELAKRGSSDRSIEQAHTLLNTRANSLPNVSAPSSRPPSPPRLTDSPVSIIVDGTHKFPAFEAAHDPHNQPKIQGGEEDAQIETETAVVGNLPKATSTVSEPNPKDIPVPESPKKEKDKQRRFTIHAALFGGDKLHHESPEKKLKKLRRRTLSLPQDEVSAEPPKNESVPAPPLGEPAADGAAVESGDFATHPVVRPLSLTIPDGHKGKEKDITSAPVYARCSCCGRLKRPHGFNSELSPVLENENLRTNFSFEIERTSGSSARRSSDASRDKFTPILPMQVGQNETRQASIEPYNGPPEPQPEQLQHTGEIDMEIAASSPVRQPLRQKNASPIKSKRNSAPPGFVRFASLHGKRNGSTGPIFEEDEEVELKADEHQPLMIEQADMADYTIQTRDFATMSQAGAADHEIAMDRPDLQVSSAARAIVEPFSAAVPNHMQLMTAGLMERTPLENPLAAVSSDTFVAPAQGKAPAGEDQPSRQDISQLLHRASIVDQPQAEPLISDESDVLEKESPRPISTTESPTSTTTTTTVTIITPTSATTATSTSMATSVAAPWEQELSASYLGGTNAMDLSLRPKFSFESMRSAIEVAEKEKDKDPASKATGKRKSALPGWMGVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG63</accession>
    <name>A0A1C1CG63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_03674</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG63"/>
    <dbReference type="STRING" id="86049.A0A1C1CG63"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03674"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01859"/>
    <dbReference type="eggNOG" id="KOG4097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT47525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="220" mass="23776" checksum="88F53DEC9AE8448E" modified="2016-11-02" version="1">MAAASRTTMLRQAQLLSASKRLFSSTTQPLRPFRPAPLLPCSRQVLSPRLSIASQVAPFSTTPQRKILPAGPQVIKGGVNDPAPIPKPDPLHGSYHWTFERILSVALVPLTIAPFAAGSVSPMLDAALIFGIIVHSHAGFQSIVIDYIPVHKHPTMRRFFMWTLNLATLVVAIGFYEFETNDVGVVEAVKRIWHAGSENDATIGKADASGLGHDGKLGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG65</accession>
    <name>A0A1C1CG65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein unc-50 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_03607</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG65"/>
    <dbReference type="STRING" id="86049.A0A1C1CG65"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03607"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01927"/>
    <dbReference type="eggNOG" id="KOG3012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT47456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="323" mass="36906" checksum="801265C33F8A21E5" modified="2016-11-02" version="1">MPVTRTTTFPSQLLSDVYVLCDQVYPMSSPRISTPRQYGGPHFGATATGRSDMRMPRFFKRLFKFPQMDFEMAVWEMTHLLIAPKKVFKSIYYHKRESKDRTNAYRYAAYSRDRIAETRNTWHRPDPSFTYLLSFFLLLTSFAWSLAYTPSFGSVVKLASMFVVIHFLAGSLLVSAIAYYLVGRLLGPGIAGLPGRRRQQGLFGPPGGTRGAEVLEFGYCFDVSIRAFFPPYVLLYIIQYILMPVLNHQNHASTFFANLLYLGAGLYWSLITFLGYNALHFLHHTQLLLSPMLAWIVIWLVCTILNINLTTVGTRWLFLGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGA3</accession>
    <name>A0A1C1CGA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative peroxisomal membrane protein 2, pxmp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_03704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGA3"/>
    <dbReference type="STRING" id="86049.A0A1C1CGA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03704"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01845"/>
    <dbReference type="eggNOG" id="ENOG502SQQ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT47540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="198" mass="22488" checksum="6121CF06DD391CCA" modified="2016-11-02" version="1">MPSITTVAVQSAILKAAANLTAQTLTRWNTQSSSPSPSPYDWTRVAEFAAFGIVSAPLASAWQRLLEDWFPSQRQHRRRSMTQESVADKDETEKSTKTTAQLSWGNILIKLLLDQTIGQFLINLTFLVCTNGARIESWSVLAGEIYARIFGLIWASWKLWPWVALVNFIWVPVQWRVLVGSLVGFGWNIFLSIWSMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH56</accession>
    <name>A0A1C1CH56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_03764</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH56"/>
    <dbReference type="STRING" id="86049.A0A1C1CH56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03764"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04536"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000046">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="94" mass="10467" checksum="179A8E97C1C4308F" modified="2016-11-02" version="1">MGDLAGRKVFKVFNQDFIVDDRYTVTKELGQGAYGIVCAATNGQTGEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRNVRSLVTMEEARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHQ3</accession>
    <name>A0A1C1CHQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DNM1</name>
        <name evidence="15" type="ORF">CLCR_03868</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHQ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CHQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03868"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08202"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034643">
        <property type="term" value="P:establishment of mitochondrion localization, microtubule-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097753">
        <property type="term" value="P:membrane bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090149">
        <property type="term" value="P:mitochondrial membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140572">
        <property type="term" value="P:vacuole fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000002">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000383">
        <property type="entry name" value="Dynamin-like gtpase dnm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="27"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="13">
        <location>
            <begin position="739"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="533"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="533"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT48040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="826" mass="91352" checksum="9A578543B71C9AE4" modified="2016-11-02" version="1">MTTLGDDLLRTVNKLQDLVFNTIGNDSLDLPQIVVVGSQSSGKSSVLENIVGRDFLPRGSGIVTRRPLILQLINIPPDDDDETANGNGDAHAPHSYTSVAEHGEWAEFLHIPGRKFTDFNQVRAEIENETARIAGNNKGINRQPINLKIFSPHVLNLTLVDLPGLTKVPIGDQPADIEKQTRTLISEYIAKPNSIILAVSPANVDLVNSEALKLARHVDPMGRRTIGVLTKLDLMDHGTNALDILSGRVYPLKLGFIGVVNRSQQDIQTSKPMSEALKAEAEFFRHHPAYRNMATRCGTQYLARTLNTTLMAHIRDRLPDIKARLNTLMGQTQQELASYGSKQFSGKEHRGSLILQLMTRFATSFISSIDGTSSEISTKELCGGARIYYIFNSVFGNSLETIDPTHNLSVLDIRTAIRNSTGPRPSLFVPELAFDLLVKPQIKLLEIPSQRCVELVYEELIKICHTCGSTELSRFPRLQAKLIEVVSDLLRERLGPCSNYVESLIAIQRAYINTNHPNFLGAAAAMSSVIASKNEKDKKAAQEQERRKREQQRRKQLGVNGAATPDDEEAEQEDKPTTLPTRKHPTVSRSMSPAVARERENGIGNITATAGSAGAARDSFLNYFFGKENGLPGAALPGSPAIVPSSASVAHRHVSHSTDPSFSQSIRRMDRGSFTDRSPVYPPAMNDDYAPASEYGDATALFVSIFACDEILIDLADRATFQPEQSAEPALTEREALETELIRRLISSYFNIVRETIADQVPKAIMHLLVNHSRDEVQNRLVSELYKEDLFGELLYEDDGIKKEREKCEKLLSTYKEAAKIVGEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIB7</accession>
    <name>A0A1C1CIB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipid methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIB7"/>
    <dbReference type="STRING" id="86049.A0A1C1CIB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11292"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08412"/>
    <dbReference type="eggNOG" id="KOG4300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33006" checksum="FBCEA7F6D1E41247" modified="2016-11-02" version="1">MSWPPLQERLLSLLEPGYLLYASAYAFVTTAFNFYVLGFNVPSRSNFKKVRDDAFSDFWTKVTGKFVPEYHGSTDLPSYPLLSPAPVENPPPLKGSATLVPPLLSRARGVVLDIGPGSGTHVALFSDNANISAIYGAEPTTGLHKPLQLRIDEARLTGKYHILSSTADKAELLPALAKAGVQVSPKGIFDTIVCVRVLCSVPNLEETVRDFHSLLRPGGELMVVEHIRNPWTTTGSILGRLMQIVYHFLGWTFFLAGCQMNRDTPAVLRRAAPWEAVELKTHFEWTALPYLAGTLTKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIP6</accession>
    <name>A0A1C1CIP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">DBP5</name>
        <name evidence="22" type="ORF">CLCR_04024</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Associates with the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIP6"/>
    <dbReference type="STRING" id="86049.A0A1C1CIP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04024"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08481"/>
    <dbReference type="eggNOG" id="KOG0332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="127"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="311"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OCT48337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="508" mass="55660" checksum="E1F62589765E6C48" modified="2016-11-02" version="1">MSETPSGGGSLADRVTKPESTSWADEVASPATENPPTTIDTNGKQPETAPADNGQLDGATEPFGGSTLQEPDFEVEVKLADMQADPNNPLYSATSFEQLGLSDDILKGVTNMNFRKPSKVQERTLPLLLMNPPQNLIGQSQSGTGKTAAFVLNILHRLDLSSEAMRKTPQGLVLAPSRELARQIVGVVRVMGAFIEGLKVEAAVPQDAAARSRKIEAAVIVGTPGTVMDMIRKRVMDVRQLKILVLDEADNMLDQQGLGDQCIRVKSLLPKGVQIVLFSATFPDNVVLYAQTFAPNANQMTLQHKDLTVEGIKQIYLDCDSDQAKYDVLVKFYGLMTIGSSIIFVKTRETALNIEQRMSAEGHKVASLTGGYEGTQRDLIIDSFRMGHAKVLITTNVLARGIDVQSVSMVVNYDVPDKFIGGGKYVADPQTYLHRIGRTGRFGRVGVAVTFISNRHDWEKLMEIQKYFNTTMTKVTTDDWDELEEQVSRIIKSSRAGSNFKEGANMQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIZ9</accession>
    <name>A0A1C1CIZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HBS1-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_04442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIZ9"/>
    <dbReference type="STRING" id="86049.A0A1C1CIZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04442"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08619"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HBS1-like protein N-terminal" evidence="6">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="113" mass="13234" checksum="3CB9DF8F37AAD6BA" modified="2016-11-02" version="1">MSNRRVKSLAHDEDDLDDYDDYDDDYEDGDNNDLSPEDKEQMRQGTVEVRTALGSTFPATDREIQDALWHYYYDVPKSVAYLKSMIHCAVQPLSRYSFYQTSRSLVLLQPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ17</accession>
    <name>A0A1C1CJ17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Cytochrome P450 oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_03959</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ17"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03959"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08590"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT48466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="539" mass="60753" checksum="2C5537BE1623CED8" modified="2016-11-02" version="1">MAVGIVLPGIAGLVVAFVLYAFLFIGRREKGLPPGPPTAPIIGNLHQIPTKGSYLTFTQWAHQYGGIFSLKLGPGTAIVLTSRAHIKQLIDKKSTMYSDRPHSYVSHNLITGGDHVLIAHYGKTWQKYRKTIHQHFMESIVTRDHLPLQHAEAAQLLHDMLTRPDQHMDHPKRYTNSIACATVWGVRSPTVDTPHMRRLYELMEDWSVVMEPGNTPPVDIFPFLHYVPESVFGNWRSRARHVGDAMNGLYNDMLAGLEKRREAGGSKFSFMDRVLDQKEKLELSRHQLYFLGGTTMEGASDTSSSIIIAAVQAFTKWPDVMRKAQKEIDSVMGEDRSPVWSDYAQLPYVAATVKEAMRWRPVELRTSRVQAGQQSDNVARTDDWIDGYKIPKGSVIFINTWGLHHDEQRFPNPDTFDPDHYKGVTALASELAQSVNPDDRDHYGYGSGRRLCPGIHLAERNLFLGISKLLWAFDFAPGKDEDGKTIMPDTNPTTGYSEGFLVCAKPYALEVKVRSETRRETILKEFEAAKRDVFSAFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJD4</accession>
    <name>A0A1C1CJD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RasGEF domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_04540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJD4"/>
    <dbReference type="STRING" id="86049.A0A1C1CJD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04540"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03248"/>
    <dbReference type="eggNOG" id="KOG2378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="453"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="704"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="328"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="588"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="927"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="954"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT48644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="964" mass="108028" checksum="6CABB4FE92AA062A" modified="2016-11-02" version="1">MDSRSTRYRSLDAKGAEPPPKTRERHNSAPTVDRRKEQHQRRPSAVTKHPDSSHRSTKSHGRVESLTAPDRRTNTRHSDRHQGPERTLEAKLSAKTSDFESSSSVNLLVLGSRNSGKSTFIRNAVGSQRSRTSTQVVIKDKYYRVQLIELLFDDVDFSSERRIEWPAYVNGVPLSEVDGVFCLYDVADKESVADVPAALTSMTNTGVPCMLVAAKCDVNEKARQVSARFHEQVRRTLAKVAIAEVSSNSSENTKQCFLAMVHRVIASPRASIRASKSSYSSMESSSSHRVISREPSPRASRSRSRSNQRLQVSKSKELLLNLSVRQTLVESENEESGSSASEDEATPPPRTPLRLDTAAASHQQRRHGGPQTPVSSGDYTNKLISPDTTMTAVPETPDSYYVKSMLRPDSASTVDSRVNQTFLDMDDDSHNLSPKTEMETLGPLLNGLKMGQDTKSEPGVPFQELVDKLLLLPASKTDSKFVPSFLCLYRSFATPLRLLTAIIDQFMKVESSKMVHFTKVAEMLRYLQVLAQWTATYPGDFAPGPARDFAIPFVQSIEKSKVFAPAAREISNNLDTIVPDEDLDWAFDDSPSPLSKRSGTGSHPNTSSSSSSLPQLSTEKARASNHKARHEADDSDDEDSANSSGRGSNTPSMSSSMVRPNNTSSQSYANYMQLESAKMEAERFKPIPRIRLSKLQWHQYMETPIDEMAREITRIDWTMYSAIRPRDFVRHVSLSTSQRRQSRAVDNIGAMVKNFNHLALFVSGMILFRDKPKHRARALEKFMALAWKVRQLNNYNSLGAIVAGITGHEIARLTATRDLTPPEVQKQFLRLTILMGISRSHAAYRMAWDNSPGERIPFLPLVRQDLTMAASANQTFIGTNINWKKFEIMGDVIVGIQRSQENPYNFPPRSVRSDEITKLILETKILEESEDSADPRSELYDRSVQIEPQQTGADPRKKFDWLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJV1</accession>
    <name>A0A1C1CJV1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TAP-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJV1"/>
    <dbReference type="STRING" id="86049.A0A1C1CJV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04896"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03103"/>
    <dbReference type="eggNOG" id="KOG3763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TAP-C" evidence="2">
        <location>
            <begin position="388"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="443" mass="49272" checksum="F56AE5681A32E4DD" modified="2016-11-02" version="1">MAFGKGGYRGGGPHGGGRGRGGGRGEGHHSGNSTIELVVKGWTSSTIPARDQKSAVLGFLKSKSGCQIISDRVVKVHILFIEIWERDKNRFYQLDGSNWSGTTIKIEESRQRTDNANKFPPSGPRADGNSHYKQHNNSGFGSQINGKNDDLFAVEVADKIAAVIRSCYTETDKHLNFTNLANHSGIQQIPDIQNATDGAKVWEAIFTICKTKVWPSNHQRNISVHLISLRQNEITNVTVIEALSRFFPRIQGLDLGDNKLENMNSLIAFSDKFRELQHIILDGNPVCYLPDTVPTLRQWYPKLKQVNNTPVETIQGAIPFPIGQPAPALGIGVGVGVGVGQTPFRPDDRYKDIPTAQIPVDPTRPWHPEIPVDSLFAVKTPDKPQDVWEREVLGLRFSIQTKLNMASTEECLKANHWDYDKALANFNEINSKNQIPRDRFLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK27</accession>
    <name>A0A1C1CK27_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
            <ecNumber evidence="4">2.1.1.359</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SET2</name>
        <name evidence="21" type="ORF">CLCR_04544</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK27"/>
    <dbReference type="STRING" id="86049.A0A1C1CK27"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04544"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03107"/>
    <dbReference type="eggNOG" id="KOG4442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1740.100:FF:000002">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025788">
        <property type="entry name" value="Set2_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
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    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044437">
        <property type="entry name" value="SETD2/Set2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SET domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51568">
        <property type="entry name" value="SAM_MT43_SET2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 21" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9 21" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="20">
        <location>
            <begin position="165"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="222"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="17">
        <location>
            <begin position="613"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="544"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="636"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="778"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="950"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="686"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="778"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="813"/>
            <end position="827"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="830"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="879"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018028"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OCT48801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="974" mass="108916" checksum="643315CE8EEB5719" modified="2016-11-02" version="1">MGRHSRESSTAPSADDGATIEVKREESVGDELAHELSTARVAAIKHEDSTSPSESPSLKPTRLKSSRSSSASTPSNRPLEADRDTSTAKKEPNEANGHHSTSTSPIKPEPKAPSKPTKGSRAASKLPPRVAPLFDHLPDATSEATSTFTVLDACTYQNKYLGFSEHALDCDCSEEWDPATKQNLACGDDSDCINRACKMECANDCSCGTACQNQRFLRRLYADVSVIKTEKKGYGLRINVDLRPHDFIFEYIGETIPEGTFRKRMRQYDDEGIKHFYFMSLSKGEFIDATKKGNLGRFCNHSCNPNCYVDKWVVGDKLRMGIFAERYIKAGEELVFNYNVDRYGANPQPCYCGESNCTGFIGGKTQTERATKLSAATIEALGIDEDEAWDTMVAKRPKKKKTAEDDEDYVDSLEAKSLDADGVTKVMAALMQCKEKWIAVKLLQRIQRCNDDQAWHRVVRFHGYQILNSQLSAWRDDENIILQILDILDRLPRLTRNKIVDAKIDKTLQSLIDHEDDRVATQASSLFDAWSQLELAYRIPRKKKEDVATSVKTETAPFERRESAQQRKRSRSRSKSPPRGPASLSAPAGPRSLQRPGANFFPRPPMPFQRGPPPLPRGWFAAQDKGRTYFYSASGQTTWTRPSKPADEPPPPPKQPSEQDVLKSIIDNIVTSRGKETKNSTPDTPEPSKSKKEEKWKSYDEEKQKKLYENTLFPHISHVMNKYKNKIPRDDLKRFAKEIAKKLVASDYKAGRVKDPTKIEDRQVKKVKEFCKQFFEKAYQKHKKHEAEKATREKDKKPKLDGETAGAPPHAPDEDEDIKMSDNELDDTPSVHSPSEANGTGTLKRKRDAQEDPAAAGGDEDGREPPGSPIKRLNMELDTPPPPPPPPAPPIETPPASTPRESQDVDMETDIFADTNFKGKSMADVLAQAQAEDDEATEDVGDVVMKNGSVLETEGETRNPMVEDQPVDQPRGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK88</accession>
    <name>A0A1C1CK88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CYS3</name>
        <name evidence="10" type="ORF">CLCR_04906</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK88"/>
    <dbReference type="STRING" id="86049.A0A1C1CK88"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04906"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02959"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000043">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000008">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT48948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="434" mass="46504" checksum="4A8B8C790425C7F8" modified="2016-11-02" version="1">MTVPVDVPVSPRPLRPHERILTNEDGAITTPARAPTPVLNFGTLAVHAGAPHDPATGAVIESISLSTTFAQTAVGKPIGLYEYSRSANPNRDNFEEAVAALEHARFALAFSSGSATTATILQSLAAGSHVISVSDVYGGTHRYFTKVALAHGVEVTFSPSIELDIEELIREQTKLIWIESPSNPTLSLVDIRHVASIAHKHGILVVVDNTFLSPYVQNPLDHGADIVVHSVTKYINGHSDVVMGVAAFNSEALEERLTFLQNAIGAVPSPFDCWLAHRGLKTLHLRAREASRNALEVARALEASPNVIAVNYPGLDSHKQRDIAVKQHRDGMGGGMLSFRLKGGHSAAERFCQQTRIFTLAESLGGVESLCEVPSAMTHAGIPKEQREAIGVFDDLVRLSCGVEDADDLKKDVLQALEKAVVGPKISNGLNGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK91</accession>
    <name>A0A1C1CK91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">tpc1</name>
        <name evidence="14" type="ORF">CLCR_04962</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK91"/>
    <dbReference type="STRING" id="86049.A0A1C1CK91"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04962"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03002"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090422">
        <property type="term" value="F:thiamine pyrophosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000011">
        <property type="entry name" value="Mitochondrial thiamine pyrophosphate carrier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="12"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="119"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="212"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT48906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="331" mass="36247" checksum="D500DD9718C4633E" modified="2016-11-02" version="1">MSRDIERLKDEGTRQQVVVAGGIAGLVSRFVIAPLDVVKIRLQLQPHSLSDPFSCDGIKGPIYKGVFSTLRAIVRQEGIRALWKGNIPAEVMYVAYGGIQFTTYRTITQAQALLPTRAPPSVESFISGAGAGAAATTVTYPLDLLRTRFAAQGSDRIYTSLIGSVRDITRHEGPGGFFRGLSAAVGQIVPYMGLFFMSYEFLHQHIGGATLPFGSGDATAGIFASVFAKTAVFPLDLVRKRLQVQGPTRGRYIHTNIPEYNQGVLRALGTIWTKEGYRGWYRGLTVSLVKAAPASAVTMWTYERVLHSLIASNRADEMWEIYTGYDDESDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKG5</accession>
    <name>A0A1C1CKG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_04840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKG5"/>
    <dbReference type="STRING" id="86049.A0A1C1CKG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04840"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02908"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5354320at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF25">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650917" evidence="4">
        <location>
            <begin position="24"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="156"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT49003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="490" mass="53648" checksum="4BEAE105164FC095" modified="2016-11-02" version="1">MDISPRALIKLLVPRLPLLLTTAILNTISLSPNSSKQDLQTEVTVVILRSILNVRKTMGYLQHISLNDPGIKGPVSIAKVTIPPPIDEAGPRDAIVRAIKELGDGSETYTLPDIVSVQAEWTGYRKGVAKNEPRPDLPEADQYRVLMAGVSNETTILYFHGGAYFLMDPCSHRQPVAHLARLTGGRGYSVRYRLAPQNPFPAQLLDGLIAYLSLLSPPDGSFHEPVPAKSIVFAGDSAGGNLAVALLQLLLTLQRIGLPTIKFHGVDVSIELPAGVALNSCWADISRSMPSINKNAQFDYLDPPTAEGISKSDPLPDDLWPARPPRAEIFCNASMVAHPLVSPLAAHSELWKGMPPAWLCLGNEGLEDEITILARRMHQGGGVVHFVGYEGMPHCFAMIFPTSPKGKDCYQRQAKFIMDVVGDAGPTSSEAIWIKAFSNPPEPNELDFEHLSKLTDDEVCSAIETMRNHAMRREQEALKKWNELQSRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKI0</accession>
    <name>A0A1C1CKI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_04665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKI0"/>
    <dbReference type="STRING" id="86049.A0A1C1CKI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04665"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02914"/>
    <dbReference type="eggNOG" id="ENOG502SK3T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10016252at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008688">
        <property type="term" value="F:3-(3-hydroxyphenyl)propionate hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019622">
        <property type="term" value="P:3-(3-hydroxy)phenylpropionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050631">
        <property type="entry name" value="PheA/TfdB_FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476">
        <property type="entry name" value="3-(3-HYDROXY-PHENYL)PROPIONATE/3-HYDROXYCINNAMIC ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476:SF3">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="10"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="315"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT48997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="620" mass="69441" checksum="A32BF959F7CBDC9E" modified="2016-11-02" version="1">MTETTPHIDETGVIICGGGPTGVVLSALLGAMKVPNVVLEREKDITTDPRGIALDEDGIRILQSIGIYDKIYTEIGTCSETNLYKKPLLTMDYTTTEGGTGHVGFICHKQPAMEKAIRDKLQRLSSSQIRTESTVTGISEDDKRVTVEYTDAHGNTHKLSAPFLVGADGKTGYVRKRYLEPKGVVMEKCKESDYDETWVALNWQISLPTQKTHPDFPLWRLGYTPEQVYDLFFPKQFRFLCNHQRPSVCGRFGLKTDRLWRFEFVILPGEDGHKMATPEETSKIIYPYITHPGSWYGLEQPVRFPEDCIKTLRSRPFSFVARSCNKWSIGRVILAGDAAHVFPPFGGQGIASGFRDASALAWRLALLHRRPTINHEAVLTAWYSERKQQLERSLAATIQNGAYVTESDPVKVFIREWYMWAIQLVPSWKRELQKGARAQGMTRYRYSPGLAFLADSVGGLLLPQVYAFNFRTNKIEFTDDLIFSEDNTGLFQLLVLPDKVAEVEPLTRGLEDINGLSGGLLLAEEATVIIQSTKVSLSAEDVPVQQRLARIAGGDEFAADPVLCKNRPPPIGYDELRLRKEVGGRKYVILRPDRFVFAACDTLAELKATAAKLSSTLHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKU0</accession>
    <name>A0A1C1CKU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">General negative regulator of transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_04493</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKU0"/>
    <dbReference type="STRING" id="86049.A0A1C1CKU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04493"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02796"/>
    <dbReference type="eggNOG" id="KOG1831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="12">
        <location>
            <begin position="467"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="11">
        <location>
            <begin position="650"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="10">
        <location>
            <begin position="863"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="9">
        <location>
            <begin position="1147"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="8">
        <location>
            <begin position="1767"/>
            <end position="2108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT49130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="2127" mass="239028" checksum="977AE369AAD0A9C0" modified="2016-11-02" version="1">MITSPAASGPSSLSKISATQILLLLDTISEREGKQKWEAKREKIQRLLDSNGMEVFSQFLRRAISLNNAAIFQGAKDHDQGSYRLLHEQLDKVASDPEQPAKIAEAIDTSKEDSFRDFDLVAFIQHFFSSDTLPQVILAVAFTKCARVDLRTKAESFLTNFAQSSLRTLSESRGASSPSFAAENICSVVEYFSLAAASITTQDQKDDLWRAITPRYTGTKPELLYGAYMVTRLPSENRDIARGLLRHGPKVLASEQAARDFLASLPASTITEPQAATAILFLILTVNQQYELSNLVEALRVRQLDWNLVIQAFDIPGLRLRRTEFPRLYGSLLHVAQEETHLDIQRLWGGTWQNPATQISLLAGFLAAPPTTVRVARIPHLRPTLPQDELKKLSPEVVNLISTDLDTPYASADACQAIFEVVLGPATGPDGEDAMDILQDVYQNHAAIFLLFLARTNAKPWASDQEKFIAECFSLFLEKQRPDYRPVLQALATQDPQYLFELCHLVFQNDPRQTEVIYERAEEFGWTEEFLKHWTNPLALDIACMRDRLRQDFDLERYLAEAAEGQTNLGLILAKYLRIKADDEFRVQRGGAPPQSIPLTLRNVHTLLEKVEDNLDDRDAVESAQTTCLQTYPRLMNYGAGFDDILERSSEEKGNKLSEVIDKQMSELFGRMYRGELSIRDMVNEMRKFKTSTDPDQQDLFCCIVHGLFDEYVCYSEYPEDALEKTALLFGNIIKYNLLPSIPRDFGLALILRAVRDHEPDTLMHRFGIEALLQISDQLSEWPGLCSLLLQEPSLHQHAELMQRAEEGLRAQQAAGNGNGHGLGANGIGSGHTVNGAADVVAQDTGRGFRALHADPPDPSAHFREPDQKVQEKILFVINNLSKDNMSSKLADLKESFAPEHYQWFASYLVEQRARLEPNNQEMYFQFVSKFGDNLLMSEVIRETYVSINKMMSAESTINSATERSHLKNLGGWLGSLTLAQDKPIKHRNIYFVDLLVEGYDTQRLILVIPFTCKVLAQGVNSLVFVPPNPWLMEIIGVLLELYHHAELKLNLKFEIEVLCKEFKLDFKKLEPGLVIRDRPQAEDEVANLSGLQDGVENFDEIGLNGAMNRAVRERLSAPEIMATLPNLEDVLKYPPTSGSPQDQAMVKNIIYRAFDQAIQEIIAPVVERSITIASISTAQLVAKDYALEPDVEKYRLAARQMVKSLAGSLALVTCKEPLRMSISNYIRRPAQEDLPEHLLPEGAILMCVNDNLDTACSLVEQAAEQRAMAEIDQVIEGDMEERRRFLAEGGNRDFMPAGINRWSAWIPEPYKQTVGGLNEAQRAVYEEFDRRVHGMNANHLPNASTDTTGRQIPDILQDPLAMPNLSTPADQPALPHQSPLVQQENRMLSAMQQPRVNGFAETVPPHERISILIEDIQKAARASGTTRVKDLEKNGSIFQDFRQILIVLTTSQRPATDLLARQIAEKICATFTQKPPESPLEAEVLAFLLSKLCQLSDLIVRDVLRWMTASEELILASSNVVVALITVGLLEISRVDAALSSSILNKNVRGLEILAEILDQTLFTDEPTALRADFANSLVAMSAWVKEQPDLLVASEISAKLKAHGMPEFVSVEVSDKTKARQDQMRYVFDEWVGIFESIGQNDSTCAAFLKELHKEQTINSTEDLAEFFRLCIDSCIECYEREAQSPRGSVEVAFAHVDALSRLVIMLVRFQGETNGAVRLSKAPYLETILTVIVLVLNHHQNMRGVAFPQRLFNRLLANLLYEYAAARLDTTSDHNEMMSAFAKCFKSLQPSWFPGFTYAWYSLIVHRVFVAGMLKSNNQAGWDTYRELVGLLLHHISELSTTAGFELLNLDLYKGTLRNILVLLHDYPEFLCQNHTYFCSRIAYGIPQLRNLILTAKPSAYHDLPDPMTPGLKIERLEEMKKHPTLAGDLDLPLRQADIRDVVLSAIRKSGDYEVALKQIKAALLEGQVRSTAMGPAKSVEIINALVPFIGQEALSNSPGRFDGNSAPVVFTTKLALSLGYEGRYQVLNAIADQIRYPSTHTDFFCKLMLHLWGSGNVDEPQRELREQISRVVYERLTVARPHVWGMTILFLELQQNGSYGFWENLAPESNMQQRLQQAMRTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKW4</accession>
    <name>A0A1C1CKW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKW4"/>
    <dbReference type="STRING" id="86049.A0A1C1CKW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04629"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02776"/>
    <dbReference type="eggNOG" id="ENOG502RZXZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840:SF1">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="730" mass="82800" checksum="1EE58D3E536A3892" modified="2016-11-02" version="1">MDFEDSGPSHYQNEKLSAVASPTDVPSGAQSPVASQSPPAWEHSRRHPHVNHARENLRHLIHPDGRKIHIAPTPEEHVKLQKELSQQQGGDQFDVVISGSPEHLAIVRELHAHHAARRDTLRDTHGDIFHEFEQVRNDLDHLSQELSQLTHHGVAMDANFGKFGYTARIRTKDDHSGACTPMGSLPGSTQGLLDNQQSRFTDGLKFFKRPVIRQYFHKGLLWRSSRSGEVGTFELFADLLYVGIIGIIGDKAAEDPTGKSFLLYAVNFTMAFKIWNDLTLVTNWFERDDIVQKLSVMLYLILLFAYTTNISYAFEDRHPGADHDTYFPMMSFYLAERFYGAFYFIWLSYVVPLIRGTLLYTSSIILLAIVFWLTSIHVNYPGQLAFIWVAIVIDLWGQGLGMFLSRASFKRAHHDKPGRLERFVRKNFEFYPAINIEHRTERTNAFVSLVFGYSVLTILYQSRASVGLNAFLGKGILGLIQAFAFQWLYFEIDHHGVHVHAIRRHWLSSTVWITCHLPFVLSYVLAAATLSKLVIAHDCANANVEDLGESYQVKSVGGLEQGLRWYYCAGIASALVTMTLLSYCHVHKRLQNPRLSKGPRLIIRTAIALAILLPFAREKLSSLSLIGTSTALVSLTLAMDIFGMSSQGDRFWTGGWCEDCKRSTHYEARIRCSRRKKQDIIKALHRGETVRLDELLRQQRTNSSAMSSTTDLGFSEDHVTKDEEWQHAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL94</accession>
    <name>A0A1C1CL94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_04821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL94"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04821"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02664"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="478" mass="53858" checksum="99D4652E55720309" modified="2016-11-02" version="1">MGRRHKNYHHKVRSGCVTCKARHVKCDEGKPGCLRCERSKKPCGGYDLPRAWIFDPYCDFDSPDGKKQGQSRTPKDLGTLGDPLPTARARLGKDLAIGSPGYVQYLLENYSGDRRGQMSLLFDYNSTEHKMWRFKFVQLMLCEPALSEAVFAAASRSMDVTAQPSSDVIFDSLAHYNKALTLLRGRISEPSAAYNDAIFWSIIALLINDQERGDWRSYGVNLRGIRQIVQLRGGAESLRTLRDRSYSMYSWAESCYAKHIDPSEPTASDEPEGSSEAPEFEVSAEKALSSIRQYSPAFFHIAKQHPLACPTIRALATTLRWLGTHPISHGSEFPRDQPEMRATLAKTWYKLLRKSASKDVERLVSLGLFAVLIGLAPLSMAEQYPHVLTRYTLELDGMIVTAASKDCALWTGLVLASMPLNVGLVPKSRWMLLQHVISQRAVGRDWEEVRDIAGQFYMTDTLESQWQECWELAMSKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLI1</accession>
    <name>A0A1C1CLI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05312"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="76" mass="9270" checksum="BBCC1D9E86335026" modified="2016-11-02" version="1">MFVCEHPPTSARTQQHQQHQQHQQHQQHQQQQQQQRRRRRRRPQAKYAEIPFEGIDFMWDVVGAHFPAEAMNDKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLJ0</accession>
    <name>A0A1C1CLJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_04664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLJ0"/>
    <dbReference type="STRING" id="86049.A0A1C1CLJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04664"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03290"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF33">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT49370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="463" mass="49890" checksum="28643EB4E1FF070F" modified="2016-11-02" version="1">MTTANAYKTAVSGVHGIFSRGRARRARPVVASPQESNLRDLNVSLKPFYDIYSGTESAYPPPIGTASFVDERYIASGGFASTQGMVDMMREQFPGHSRIAPGEPGKDYIEGIDDCDRRVPVWYPKDSIQMCGTKAHEVMAKPLENAGVRPPETRSSLSRSSTARKRAQGGTTFGPTMTKFEINERLFEDLKGKVVIITGASSGIGLATLKFFISHGARAVAADINPLPPDVEGADFRKTDLTSWAEQVALFDETVNKYGRIDIAHLNAGVGEIENVFVDHVDANGALVEPDFTVLKVNLIAPIVGTKLAIHHMRKQPGGGSIVITGSGKAFTGVGGTPMYATAKHGLLGLVRTLGPDLHRVNVRINLMCPFWTDTGIIPPDLLAKNASAKRSMQPPSACARAVAHLGMDPSCSGKVIYVASSTYTDVDAGLMATRPLWLGQRNHDDRVVWEEDPSNAEFSTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMT6</accession>
    <name>A0A1C1CMT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sphingolipid C4-hydroxylase SUR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SUR2</name>
        <name evidence="8" type="ORF">CLCR_07190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMT6"/>
    <dbReference type="STRING" id="86049.A0A1C1CMT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07190"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08742"/>
    <dbReference type="eggNOG" id="KOG0874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102772">
        <property type="term" value="F:sphingolipid C4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="188"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="440" mass="49885" checksum="298DDB309CABB30E" modified="2016-11-02" version="1">MANVTLSELPPLPSYTLRPRPPMLPGISDPVLQLLSPVVAYWVVSGFFHILDVYDLCSRYRLHTPAEVLKRNHVTRYEVLRDVILQQIIQTAFGLLIAQFDPVETIGREEYDIAVWAQRLRRAQGYLPGVLSVVGIDSLSLGRKVQHSYPQLAGALSGGIYPTHSFALWETTAAKFIYWIGIQLVQFTVAILIVDTWQYFLHRAMHMNKFLYTTLHSRHHRLYVPYAYGALYNHPLEGFMLDTLGTGVAYLVTGMTVRQGMVFFTCATIKTVDDHCGYAFPWDPLQHITSNNAAYHDVHHQSWGIKTNFSQPFFTFWDRILGTAWTGGDVSARYQRDRIAAQKKLDAEVALTQPSVVNSPEIDVQNAQQQARSSQRQVLDDRQHGGPQILEEEAREEREVKSASRRSTRRKSGFDAKSISDHIAGFHSRSPAILHADGMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN38</accession>
    <name>A0A1C1CN38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rhlG</name>
        <name evidence="4" type="ORF">CLCR_07410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN38"/>
    <dbReference type="STRING" id="86049.A0A1C1CN38"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07410"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08834"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF8">
        <property type="entry name" value="7ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="293" mass="31190" checksum="1026BDA0DA461B78" modified="2016-11-02" version="1">MTSTADLRVSSLFDFRNHVVLVTGGATGLGEMAAQGFVQNGAKVFIASRKESELKKTTDRINAIGPGKCEYIVADLKDKAGCDGLVKEIKKRTDRLTVLVNNTGVTWGAPYDDFPESGWDKLMALNVKSIFYMTVGLHDLLLKGTNADMPSRVINIASMAGIQTTDVTASGDGGLSAPGHGTYSCTFDSGLSDATILTSSLDGPSKAACIHLTKIQASKGVFPSRMTNFGIQKYMDTLLERQPTGRVGKPSDFAGLVLFLSSAASAHMTGNVIEIDGGSNLTGWRAKRRDTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN73</accession>
    <name>A0A1C1CN73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN73"/>
    <dbReference type="STRING" id="86049.A0A1C1CN73"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07267"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08848"/>
    <dbReference type="eggNOG" id="ENOG502SKJM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256055at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677">
        <property type="entry name" value="YALI0B19030P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="42427" checksum="BC93A597327702C0" modified="2016-11-02" version="1">MAPGILVESHTENRPTGFAKLNQASSQAATFDPVRHLAYVPPKSTHSFDDLCLPASPLSDVASTDPFPLLSEEALLEHRRELLSDRVLENCMYKTRPGSVQLRGMAPYYAPFIHQFWTSPEVLKIISGLAGIDLVPVFDYDICHTNIQLDSDDAEAVRKIPVIPPSAPVPEGTDESRTSVGSQPSATKHAVVPWHRDSYPFVCVVMLSDARYMTGGETEIQRGDGTTTKVRSPQMGGAVVLQGRHVSHIAIPTGNMPERITIVTSLRPRDPLLLESSSLMNVRNKSQLPELYYQWSSYRLHLLSERFRLEAERLDVAHRKEIQATEGGKGSCKTDIVDLAGLQKWMDEQMMYMKRTLFEMRPVTAEDSLHKNEIQEMTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNE1</accession>
    <name>A0A1C1CNE1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07645"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08902"/>
    <dbReference type="eggNOG" id="ENOG502SPRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3758478at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050977">
        <property type="entry name" value="Fungal_Meroterpenoid_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598:SF1">
        <property type="entry name" value="AUSTINOID BIOSYNTHESIS CLUSTERS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598">
        <property type="entry name" value="AUSTINOL SYNTHESIS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19165" checksum="157EE63E1417E6D8" modified="2016-11-02" version="1">MTSKAEMQANTVQRFIDGWRKYTPEAFLATWSSDCTQQTLPFASGTPVRTRQHVEHLFPILMTVMTEFELTIHNVVHDVPQGQSVIYALTKAQLPFGPYCNEHALFLWFNESRTEIMKIEEMFDAVVMKEVLPKLDQYIAQQKAEMAESRGLSLEARKPAIATFVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNG7</accession>
    <name>A0A1C1CNG7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein FYV10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein fyv10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ranbp9</name>
        <name evidence="7" type="ORF">CLCR_06771</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNG7"/>
    <dbReference type="STRING" id="86049.A0A1C1CNG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06771"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08933"/>
    <dbReference type="eggNOG" id="KOG1477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="171"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="6">
        <location>
            <begin position="448"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="504"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="511"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT50023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="668" mass="73711" checksum="D11F2E9892664F28" modified="2016-11-02" version="1">MTDGTGSSSSSRPSAFGGNAPRRLSYASVASGATSQNIHHPTRSGAFSHLAATTPGGTYPPEYQAEHQYQRRYSEHDQDSLAARDWRKPTPLPSYSRKFANLPSLGTGTMPPNPFFVPSYLRHSRYMAKLEAAYKAKLKRDREQPSGASTLGSFSTSPGNTRLAPSHRGMTYDIIESNPPKEEEVLPPLPSRWSEQDKYPGLDIMNDGQDLRYSGSASKAEIEAASVRTNHAIPPACGMYYFEVKIEQKSKDTAIAVGFSTGEASLERLPGWETHSWGYHGDDGKMFFGEHSGRSYGPTFGAGDIIGCGINFNTWQAFFTKNGQDLGICFKELKKDMKLYPTIGMKKHSGALVTGNFGQRPFSFLINDKMLSEQVNVSRDISKARITSLQRQRDENSLIQELVAQFLGHDGYVETAKAFAEETRREKESLSNVLPANTPTVTGQDDTDAVHRQRIRRAILSGDIDQALEITHAHFPTVLAENPEIVFRLKCRKWIELISKTTDLNTRKPPARNDRRPSNGVDKPHSVDDDLAHDMELDPDNHTNGVGKSRADHSGLQHDQLLQEVMLYGQELHREFQHEDGEHAKALQDIFSLVAYNDPKGSVHGHLLDASGRTAVAEELNSAILVSLGRSPSAALETAWKQTEALIDVLSEEGGPAAFVNLQATFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNH8</accession>
    <name>A0A1C1CNH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07767"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="119" mass="13146" checksum="DBC010369C11FAAF" modified="2016-11-02" version="1">MKDPTNSDKTHGAHQTGKIKLEPANSTIPDGRVDVSANPEADDLNCERSWWDKRNGVKPVCGRCAKLRREKCQRPSVSPWRTRSHMSDRLRRAQSSTTPAQQYADSATPKGPLPGHATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNR0</accession>
    <name>A0A1C1CNR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arabinose-proton symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">araE</name>
        <name evidence="9" type="ORF">CLCR_07146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07146"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09050"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF78">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="19"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="437" mass="48503" checksum="1C2709CED63CB310" modified="2016-11-02" version="1">MEKLSRWNVAHRLQKRSLLIAVAGLSILFFGYDQGMMGGVNTSFDYYTRMGFGPRGADGGPVVTKTLLQGGIVAVYYLGTLVGALIGGTIGDRFGRVKSIFIGAIIGIVGASLQCSAMNHSWMICARLVNGWGTGILNAIVPVWATETAEHKSRGQFVAIEFTLNIVGVVIAYWLEYGCSFYGNGESSFIWRFPVAFQIPMLIGLAAVVLFFPESPRWLVKMGREDEARYILGRLRGDSLAEEKELAEAELQDIIQSTQYERNNFRKQSYLHMLFGVRSGKLHIGRRVQLVVWFQIMQEWIGIAGVTIYAPTIFGIAGMSPEKRQWIAGLNNIFYMFSTLICVFTLDRIGRRWTCYWGSVGQGIAMALAGGFSRLGQNARADGDLSKASSYGNAAVAMVYIFTFIFGATWRRGYLRTMGWDRPGDLNIHCGRTIVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNS1</accession>
    <name>A0A1C1CNS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_07219</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNS1"/>
    <dbReference type="STRING" id="86049.A0A1C1CNS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07219"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09043"/>
    <dbReference type="eggNOG" id="ENOG502RT4C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="27"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="358" mass="39918" checksum="0FC43C5B0DF3FC7A" modified="2016-11-02" version="1">MGSISHMKLKRTPLKNSGAIDHLEYVDVTPIIGREYPTAKLKDMLNASNSEAQLRDLAITICERGVVFFRAPQDDLTVEEQKKITDLLGKLTGRPEDHGLHVHPLYNDPNNIPMADGTTDENIYVINSEAMKKLYATMKNRPNSASEPKDLGREWHSDCLFEECPADFSFLRMQDTPPSGGDTLWVSGYELYDRLSPPMQAFLESLTATCAQPVFESATKAGGYEITSPRGSPLNHGMNFSPVHPVIRTHPVTGWKSLFAGVGLHVSRINDVYSYEDQMIRDYVLRLITRNHDCVARLHWTKQACAIWSNVCTLHAATPDTHLVDGNRTGVRASGIGERPYLDPASTGRREGLGLPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNW7</accession>
    <name>A0A1C1CNW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2 type zinc finger containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06748</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNW7"/>
    <dbReference type="STRING" id="86049.A0A1C1CNW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06748"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05804"/>
    <dbReference type="eggNOG" id="KOG4124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000676">
        <property type="entry name" value="C2H2 transcription factor (Sfp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="564"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="689" mass="75134" checksum="E19CCD9216FA707E" modified="2016-11-02" version="1">MLELEDSPPPLNHSPSPSDRSQFTSRDTTPVTPVGNGPCFRKTEKDLLPWFKKPIDVGRTTTRLCLDTDTSLLAPDFDDNTFPTFGVSPPQPGMASVARPFDISVRQTSTSPRGNQPSNLTSALQRSDSEEKRMMANAAPDTALNRPIPQMPASSSSDFSNFEHGARPISMKGRADDRARRESLAQSLNAGMSWGGISVGSWIRDDMVMSGTSPFTFNSPSFHSSSYLPKLEANFMKDFSCCGLTLPTLHDLLQHYEEAHAQKDPVQPHAAQHTVPDSRAAIAATTAAQVQQEAQQRSQQQQSQNAPGRPFGMQQPAAQNVHRPSTGFSSTLQTIPDMDTVEDMEMDDIDGADETTPPPNLYTQNTQSSPQTSFAAPSQQPQIPQLNTTMMQGHQAYRQSTPSTPVAPGRNAARFQGNTSSTLMPNPMQQFQDLQTGYRGTPDSSAPGTPGEMADGMMDGMDDMSMQNMALYNGLPNGMGGYGFGMNNDMIDLCIDEPSKRLFSTANQGMGQAQTQQQQIQNRLGTGQYAANSDIARTIRERQVAAGLPDTTTNILPHEEPKPFRCPVIGCEKAYKNQNGLKYHKTHGHNNQRLHENGDGTFSIVDPDTQAPYPGTMGMEKEKPYKCDVCQKRYKNLNGLKYHKTHSPPCNPDLQLNANKSPSLNMPGMVAGQHSGNMGAGLSGDLSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP44</accession>
    <name>A0A1C1CP44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxin Pex22-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP44"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07026"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05731"/>
    <dbReference type="eggNOG" id="ENOG502SHU3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5327700at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="511" mass="54498" checksum="3A63CA5AB1659FF8" modified="2016-11-02" version="1">MSYSYTVTERKRKTTSSGGYGYSGSRSTFGYWVPLALTVTAATIGLAAWVWGERKDEEYDSSEDEHYQGGAAQSGYTMSGGISGPPPPGGFQGPPGPPLEPMMPGPLQPGGFGPPGTFQGPPPPPGGFQGGPPPPGWRGTEEEWRSTARSTAVEQEQETGLVARMSSALGFGRSATPSGERSLGQNPAQSYDWTNRPFASATAAAGAMVGAAISTLSGGGGEGYEDHERWSEEAEQRDNDRQIKQGIKRRGTAEEFFSGSVELPRSASIASPKRKTVAVVVSAVGDADGDVGDHASILSHLPEYIDPETTRVFVLIYAPDLKAHPLSSSHTPGRRSSQSMASSFSNISQTDAHTPAVTPGDFPSSDGILTHVDPKPIDESSSLFKTLYSQAIGIVDRDTMVLPYTSPNGHKHILRSLAPEVVYIQESLCGRDGEIVSDLSGWVRQTVIVIGDEGGHGGLIDTDDEGSAVGGYKRGEKWWQKEERTGVGRRVAVVESLKVGEDWERRINEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ03</accession>
    <name>A0A1C1CQ03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ03"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ03"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07268"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05437"/>
    <dbReference type="eggNOG" id="ENOG502SHU7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5078320at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF2">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="2">
        <location>
            <begin position="6"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="399" mass="44157" checksum="91AFACC4AF344E22" modified="2016-11-02" version="1">MPSMKKKSVYTNITPIPSHIPRQLAIDMLHSHGEIIELNPLVIGYKPIKAPQTAPADEFFSTWYEINERIQYVPGIGKAGAGKISFKGCFHDMPWGLQTHVYAPMGVDLRNKWQIRGNQPGEPPESRELGSNAPPEGLYLREDIEIKCNPAMVSFVKKEMKAASKTMVDRLVKKAELIDSGVLSAMFEQGKLKTMNPADRSQTFQQQGHYSPSLLSPMPQSAYPQSAYPQSPSMPGFQQSAYTRQSTYGGTPSPQPQPAQMSPAQGLAIEMPGSTHYLQQPPPIPQQLHPNQRFSSAVSELSASSPNQSDFPHQSSQSDRQSYAESVSSMPGSVARPGGMASPGIEKRTFVAELPANHGSVPERSPRSPDPNYMSAQQQQQQQQQQQYRYNPQDYARMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQG4</accession>
    <name>A0A1C1CQG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_06594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQG4"/>
    <dbReference type="STRING" id="86049.A0A1C1CQG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06594"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05273"/>
    <dbReference type="eggNOG" id="KOG2277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF113">
        <property type="entry name" value="POLY(A) RNA POLYMERASE CID11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="141"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="362"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="478"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="619"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="766"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="900"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="619"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="852"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="930"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="949"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1032"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1047"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT50747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1069" mass="116850" checksum="231964088455646F" modified="2016-11-02" version="1">MSYGVLEDDGNSAPLPMTAPSTKASQSNMQVDANRSPPASAARRTHVSSQSKSMPSTPFQRPESRSSPSPEPPAKNGSPLSLPSDKSHTPSAGRNRYGGCKYETGMQRARRRVPYSLGSDPLEKVKSELKVRLTREEDERLTQEVQKLYEQLQPTAESEERRSRFIQKLDKILRERWPTSSIKVNVFGSTGNSLGTADSDVDICITTDCKEMERVCNIAELLARHGMERVVCVSSAKVPIVKIWDPDLQVACDINVNNPLALENTQMVRAYVSIDSRVRPLAMIIKYWAKRRILNDAALGGTLSSYTWICLALNFLQTRDPPILPTLQQQPNLQVKEVAGVNVSFDRNVEAYKDYGSRNKSSLGELLFHFFRYYGHELDFEQNVVSVRLGRCLSKAEKAWQLLQDNRLCVEEPFNLSRNLANTADDTSMRGIHLELRRAFDLIGDGKLLKCCEQFVYPPDEIKPSEMFIPPSARPVIAQFPTQGSRGGRNAARSARSATSLGRGSTGRRSSNPSVRNANYVRNLPYSMMTQEQQLQQQHQQHLLHDQLFQQYRYLQMQEQELRMQLYQQSLQQRGFMATYAQQPYGQYTSQDEGDANGIGRAPLSAPLYQNGFPRSPYLSASQLSQGVSTNPPSPRLNSGLPEMRRYSRRTSVTQSSLGGSLRAQSQPARAVPLTTLGQVHRPDVPSLQDAATDRRSSASSTSQAEGYGGSLENGYGILGSIYDPVRRPAEYVGYYVGQPSSLSAYTHSTGISPVPSHVGLAIQNGGLSPQLAPASTRPSEVMHTPPLRTTVPTVTAEPRSEPEPASQQTERGERQAEAPKSRPGPLIVDGSINSPRRRRTTLSLNDPEDNVNISGSTSEDLAFDTPSSSDEQSQDAFESVPSIRGSPISSLHIQKHAFPNGSSEYANGHLPLTNSSARAHNEAARPPDAAGLTGLGATKKAGGGAWPLDRHLSSVEEVRTPTPRVETFNCGGSLDHDDPMPSGAPAPNNQGHGHEKALTSRTNGIGGNASGSPQGASPAFGVGGGSGWQMQKKKKSKRKTVKSENDAQPVNLSSGETPPADEFLRKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQJ1</accession>
    <name>A0A1C1CQJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_06972</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQJ1"/>
    <dbReference type="STRING" id="86049.A0A1C1CQJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06972"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05248"/>
    <dbReference type="eggNOG" id="KOG0234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000031">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001280">
        <property type="entry name" value="Related to 6-phosphofructo-2-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF39">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="45"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="482"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT50777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="539" mass="60889" checksum="18C4EC27CB2B9BE3" modified="2016-11-02" version="1">MDTLLTAESAVNSPRYRRKSSTFVDAIHDLPEKGEMAPAQLYSTESGRLFHAGRIAIATVGLPARGKTHISVALARYLRWLGVKTRIFHLGDYRRAIVGQGSDVPDDYFFVNASASSVLLRQKILKKCREDIYHFLNHENGQIAIYDAVNPLSAGRKSLAKEFAKHDIKCLFIESSCDDQRIIEENVRSVKISSPDYIGWPEAEAVKHYLNRVSAKIPHFETMEESDLDWIKMINAGERLVVNNTSFGYLSHRIVFYLLNLHIKSRHTYFARAGTTLEGESFKADAHLSAQGKDYAKKMSETLLKHREEERRALIEKGGINAPLKPLIIWTSTRRRTVETATYLQERGFKVRQRSQMSQLNPGVCEKKSEKRIRREYPEEVLKHDLDPYHHRFPRAESYHDVAVRLEPIILELEREQNDLLIIAHESVLRVLYGYLMACNAADIPFLSFPRDEIIEIIPASYNNEAKRIKIPNLPPEIIPASPEGIKAPAPPSGFATPVPGLGSGLASPRTGTSTPEPGSGYKTPEDSENLSLRMHDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQJ5</accession>
    <name>A0A1C1CQJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">lys4</name>
        <name evidence="21" type="ORF">CLCR_06653</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQJ5"/>
    <dbReference type="STRING" id="86049.A0A1C1CQJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06653"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05269"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01582">
        <property type="entry name" value="Homoaconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01674">
        <property type="entry name" value="Homoaconitase_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000013">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000016">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039386">
        <property type="entry name" value="Homoaconitase_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="92"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="602"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="729"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OCT50752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="828" mass="89882" checksum="030E2E8C891E5CB7" modified="2016-11-02" version="1">MALFSLRTVRAAILPAVINGLSPPKTRIMFSIRFSRSGSLRASHRVQWASRSFHQTSRRLQDVFHAQLEDPNAAAVLSSLKTSPKSPQTLTEKIVQQYAVGLAKDKFVKSGDYVTISPHHCMTHDNSWPVALKFMSIGASKLQNPKQIVMTLDHDVQNKSEKNLTKYRQIEEFAKKQGVDFYPAGRGIGHQIMVEEGYAWPGTLVVASDSHTNMYGGIGCLGTPVVRTDAASIWATGRTWWQIPPVAKVTFRGVLPKGVTGKDVIVALCGLFDKDDVLNHAIEFTGSEETLRSLPIDARLTIANMTTEWGALSGLFPMDSLLQGWLRAKATMSALDASAGRLGNERFSHARLDELFNQQLTADSGAQYAKYLHLDLNTLSPYVSGPNSVKVATPLNELEDQNIKINKAYLVSCTNSRASDLAAAAKVFKDAAAMNGGKIPKLADGVKFYIAAASVPEQQIAEEAGDWQALLDAGAIPLPAGCGPCIGLGTGLLEPGEVGISATNRNFKGRMGSTDAKAYLASPEVVAASALHGRISGPGWYERPEGWSGVIRGEGDGIREEDRMITADEAFDKIIKQLDSMIDSAEETFGETQQANEATTGSTEVYPGFPERVEGEIIFCDADNINTDGIYPGKYTYQDNVPVEKMAEVCMENYDSNFNAIAKPGDILVSGFNFGCGSSREQAATSILAKKIPLVVAGSFGNIFSRNSINNGLMGLEVPKLIRRLRETFSESDSPQASTDPLEPVGNKEEQQSLDSPPPAVTRPREKQLSRRTGWTLVWDVKKSQIEVTEGATGKTWVEKVGELPPNVQEIIAKGGLEKWVQKEIAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQR7</accession>
    <name>A0A1C1CQR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NOT2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_08489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQR7"/>
    <dbReference type="STRING" id="86049.A0A1C1CQR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08489"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09484"/>
    <dbReference type="eggNOG" id="KOG2151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="292"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="462" mass="50960" checksum="DAC28837B2802076" modified="2016-11-02" version="1">MNQHTQSRTANSNRVVAGKPGAWGQSGLPAPTQQARDAIAPDSWAQAMGARPNNTQLDLSASSFPSLNNGGLQSQSHNVGSSAWQTGPPQNEQAQRQQMQSTRSHLASRQQQPATGRDGFYPTDTYSRNAPMEFPSDNSSQTVRRASQAPGGPPGLTQRQPNQGDSTPQDPSRVTSPSGQTQISRSPISQSINAAIGQERFLGQEGRSQMQESPPQALGLQSRDMFADREPRLDHDSVFAGMTEKEKFGMKGYVAEQDNASPAMRSLMRGVDLSTLGINMGSQEPLLQSYPGPWAEPNAAPLRPLDSEYTIPDCYTVKKIAPLSTRITGFVDETLFFIFYTMPRDYIQMLVAQELVARKWRYHMREKQWLTRDDASPSPVLLDDKVSEQGYYIWWDTKLWKKVRRIYTLRYEDLEEQPSMGNRPIHAGAMGAMSGGLNGGMGVGNFNAVPSLERMAATGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR07</accession>
    <name>A0A1C1CR07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_08524</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR07"/>
    <dbReference type="STRING" id="86049.A0A1C1CR07"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08524"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09545"/>
    <dbReference type="eggNOG" id="KOG2345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000550">
        <property type="entry name" value="Serine/threonine kinase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000374">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="32"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="184"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="365"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT50901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="456" mass="49465" checksum="7442B8D697E4AC38" modified="2016-11-02" version="1">MANTILDIFYSLTSCICCFPSTPQLKINSRSFRMLRLLGEGGFSYVYLVQDTSDSALYALKKIRCPFGQESVSQALKEVEAYTLFAPHPNIIASIDHAVLNDSTTKVSGIGAEAGNGGASKTVYILLPYYRRGNLQDMINANLVNHTRFGERRLMKLMLGVCKALKAMHQYRVRNSASRSAAQAIRDEAADEDADAAQRRAKTTKRTMTASAQNQEEISEEQEEPMLQPSDEVTRAQDGAKPGETCAYAHRDIKPGNIMIDDDGRTPILMDLGSLAPAPTPITSRSLAIAVQDTAAEHSTMPYRAPELFDVKTGSVIDTKVDIWSLGCTMYACLVGKSPFEARSDETGGSLSICVLGGDWRWPDEGNQSKGKGKVGSAPSRSNTAQSTNGDANKAPEASSARIYPHPAARDVVRRCLQVEPAERPDVDELMTLIDTCLSELPEDDEGGGAEVDGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRF1</accession>
    <name>A0A1C1CRF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase activator Bem1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRF1"/>
    <dbReference type="STRING" id="86049.A0A1C1CRF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08224"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09719"/>
    <dbReference type="eggNOG" id="KOG4773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090726">
        <property type="term" value="C:cortical dynamic polarity patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902917">
        <property type="term" value="P:positive regulation of mating projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032878">
        <property type="term" value="P:regulation of establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11878">
        <property type="entry name" value="SH3_Bem1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000093">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000184">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000250">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000041">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035548">
        <property type="entry name" value="Bem1/Scd2_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="157"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="320"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="439"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="615" mass="67540" checksum="ACBE378D628B232C" modified="2016-11-02" version="1">MKAIRRSLKSDKDGRHPPNLSITPKTIQALPPKKVIKALYDYEPQNGNAQELAFHKGDFFHVLSREDDTEWYEACNPLIPSARGLVPVAFFEVVGKQQRQSGSSVASPADKADGHDSGFSEKGSTNSGHTRSESTATTRPSAGPHQRGLSMSGRGTGAMVYGVVQYDFHAERADELDAKAGEAIIVVAQSNPEWFVAKPIGRLGGPGLIPVSFIDIKDTATMQSVPDPLEAVRKAGVPRVEEWKKFAAEYKNSSISLGKFDNPQAQMSAEMARMSLQNAPSQQPPPPQTEYVSGGSRLELDTRKLMNPNQTGARLSQQSNIPLAPVSASVPRYCFDNDMYWYIIECQMEDGRWWELSRYYADFYDFQIALLEMFPEEAGNKGKPRTLPFMPGPVAHVTDAISNGRRQNLDEYIKKIVGMPPHISKSMLVRNLFKPKPGQDFEIDPNALGEDYRLSGGSQHSLPPVSRTSSNQQPPGVAYGGMPPPSARSSQQRGPVPMSSGPGMPMGGPPFLHTQPSNLTQASNSSSMKAGNAGGAMKVKVFFQEDIIALRVPQDVVFVALKEKLIERLKVNEEIVIQYKDEPTNSLIDLENDDNLDVALQRNPKLTLYVNYAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRI6</accession>
    <name>A0A1C1CRI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAC3/GANP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRI6"/>
    <dbReference type="STRING" id="86049.A0A1C1CRI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08482"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09720"/>
    <dbReference type="eggNOG" id="KOG1861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000006">
        <property type="entry name" value="Putative SAC3/GANP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="219"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="479" mass="54305" checksum="3076E6D69FAB0E9C" modified="2016-11-02" version="1">MSNTPPPPPQQVPRQKVVWSPDVRDYVNRSFAKAAEMRTVSKEQIEAKLKEIITDATQSGNLDRINWKELPLPQQMILEERNRALLAPITPPPFVSPVAVPAPTTSYHTQPDVQRKRKSTELSAEGDASAPPPPWKSNGQQAGSLADRVSFNPKEKRPKLDMSTSVSKAGASLESRRRRFEDMRGDSNSPRTQDSSRGASPEPKTMGPIVGRSQKLEKNYFRLTSAPNPDDVRPLEVLRKTLELLKKKWRSEANYVYICDQFKSLRQDLTVQHIKNEFTTSVYEYHARIALEKGDLGEYNQCQTQLRALYKQNLGGHPVEFKAYRILYFIHTCNRTDMNDVLSDLTPADKKEPAIKHALEVRSALALGNYHKFFKLYLTVPDMGAYLMDMFVERERLAALACLCRAYKPDVRLRFVTEELGFESDEEACQFIIDHAPDESSTLLEERDGDVRFLTGKAGSIFHIAKAKAFGHIDIKGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRY1</accession>
    <name>A0A1C1CRY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08258"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06839"/>
    <dbReference type="OrthoDB" id="10439861at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="623" mass="68699" checksum="4AC26226D684A3BF" modified="2016-11-02" version="1">MQRCIADNPHCISATSLPRFRLPIGTAAASCLGIINDRLVLSPEALLWTAQSKQLKYLACSSAFWEVSILLTQQQLHRKVFLIDPDSALTENDSHPRSSLPMPLEGSPQPISEGWNFIESPAMSPTSNSPSLDDLFEANRLNLIVNPLDMFRPTVRNVDTSTYKPIFPDWEQTLSPVQIDPSVPRDYTVNAFFKNPAEIGLIRAIERGLERDDDTFLSPTATACSLSDWIEADPFDDANAVSTESPIPKQEPNSSPESVFDAEPVLRELNTFDPDFFFEAPSDVAPLDSPLADSLVGNGNVHPLLDSRGPEAFTPLGNPFLDPPPTYHYPQQISSHQQHHSPLVHTPASGHNLVRPELTELDSTQIPVPHCDETDVDFCDPFQPAWDFADNLGVTISEEDYQSLRGYTDTPLSPGTSAEQSCVQGANDSDRPEGERQEACHLRRSHLLSNLPRLTVSQSEPKTFVPTQPRKHHPPPPPPPRGSRPLASGLPSYPPVVNPRPILPQHLQSVPLANPWRIGYRNPWFNRPDVSWHQATDPLTGNVVGYCLRQEQAMPLNFASAAVVPPAIPVQPRPWAPSGRILLTAKPALPSAASSLRRAAEEEANGHRSKVVIVQGVPYHRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS28</accession>
    <name>A0A1C1CS28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">arc2</name>
        <name evidence="7" type="ORF">CLCR_08616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS28"/>
    <dbReference type="STRING" id="86049.A0A1C1CS28"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08616"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06779"/>
    <dbReference type="eggNOG" id="KOG2826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072697">
        <property type="term" value="P:protein localization to cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000003">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000005">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="385" mass="44452" checksum="C00661550CFC67BD" modified="2016-11-02" version="1">MLLLDYQNVLIQSLLTERFSGTTPPSTIDQVVSDFDGVTFHISTPTSKTEILISLSIKCYRELVEYGAEQVLQREYGNYITTTEAGYDFSILVDLDKLPPTPEEREDLVRRISLLKRNVMAAPFERAFDEFAALAEEAAKYTSESAPQGVEEGGQVMAIHYREEEAIYIKASHDRVTVIFSTMFMDAVDRIFAKVFLQEFVDARRRAIQNAPQVLFRSDPPLELQGLRGVGKTGEKGEMGFITFVLFPRHLTRQRREEVISHIQTFRDYFHYHIKASKAYIHSRMRRRTADFLQDPRRKKRRGRQQAAGHLEFKAEIVGPVCRLFMYKVDIGPMRPLSADRYHSPTTLRKWLPEVSLHIYGWDASREQWNAQSAARGQKNIVRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT19</accession>
    <name>A0A1C1CT19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT19"/>
    <dbReference type="STRING" id="86049.A0A1C1CT19"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08283"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06443"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF5">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="26"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="606" mass="67676" checksum="B30EE17649C9D32B" modified="2016-11-02" version="1">MADPDANPIMGRRPYTGTRYTHQHPQLGSLTGRLIKSPHFPGSPVVQFCSIPFAEVPKRFAPCIPRDNIPDHFDGRPHGDFTQFGAACPQVGATKPSWFAAYGGALDDDLGVSFDEFTCLTVSISVPETCLSVKADGQALERRPVMVYIHGGGAQEGIGHVDGLHANAALAAYSSELSLHAITVNIGYRLNWLGSLVCQDVLDEYNADPSISPHGPFNLTIQDQRAAFAWIHKYIVGFGGDPDNITAFGESAGSIFLVYQICGSPERLFNRVILQSGVVFGHGTSEQKNAEYQGLLKHFGIEGTSASERLEKLRHVPAELLAEYAGQHTLPFVEDVPGMKVKKPLFPRGSPSFSEQTSLISSCPWLEDIIIGDDFWEGYVFRDFIRGASPIRLPDTIRSIFPDQLADRLLDAYDLPGTPELAERVDDNLFWGNVMYFVGDLLFSQPIHNMANELALHNAPAAGPAKKRKIYRYSFGLTNPFPGSDHSFVTGHHFVEILFLFLTLLDRYPRHRDRWLEKQAKETAKRWIMFAHGKEPWDEYVVRQKSEIGDSRMAVCDDIRGWHVKTVSQDEEESKSDPWGRRRYDGWAALEDAFVSLKRPDGREDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT22</accession>
    <name>A0A1C1CT22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT22"/>
    <dbReference type="STRING" id="86049.A0A1C1CT22"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08913"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06481"/>
    <dbReference type="eggNOG" id="ENOG502QQEE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5385910at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="304" mass="31779" checksum="EC05F61257C995FE" modified="2016-11-02" version="1">MAPIPVHTASAINTNLPSHALGTSPSTAGARYTPSTAEARPSSTEPTLGASPSQPARAAVPHPTNTVASTHNSRCNPTPTASLQPASLSTSENTPPPPQPGAVPSPYSISPTPRASAPASPRCLNVPQPNAYASSDASPPRVTAAPTQAQTPTHSRPLPIHPATYHSTVCTPIRSVPSAGVTSISTSPSYKYTSPTYSLPQVPEVQDLSHPPGYQQDHHSSFDDKPVESCQETDYRATLSPVSATRRGAGILDLEWTFGSPNGSANGDNTVVQTAMSWARAAGKRLSMTEKQIWKTINGEEDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT43</accession>
    <name>A0A1C1CT43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G-patch domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_08400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT43"/>
    <dbReference type="STRING" id="86049.A0A1C1CT43"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08400"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06419"/>
    <dbReference type="eggNOG" id="KOG1996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="321"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="426"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="499" mass="54604" checksum="1F9FD81C998F2C49" modified="2016-11-02" version="1">MANNTATPARGGLSLYANLLDPKGAAPGTISSAPVSYKPGEGSPEQDEAVKKQQALAASLRFQPTKRPQVAAQKAKAKAIASKFSIPPPATTPTPAAEATGPGTTDPLSSQPAAPRTTIADWTATASDDEDFSHLYTEKRPRGGRKKRKKNKEAAPVTQNWDDIYDPSRPNNYEEYKHSEEKIREVREWKDLLYRHRMKRRDYSDSEDEEYRRPMNKQFAPPPMAFAPPPNLNDESPPPPPPPADIPDDPTGEDAYLRRLRLTQSQAPPAGQISRAPVRYNVPPASEAMPPSEEELEDKPADVEAVDNEDADQPRSKRPGQVGFAERLMAKYGWSKGQGLGAQGTGIVNPLYAKADKRKKRADAEGGGYATPAGTGKILGGHKSKTAEAEEEGKFGAMSEVIRLEGMLTGLDLDDELAQGEGGIMQEIGEECGDKYGSVERVYIHRPESEEEEALVFVHFVSQLSALRAVNALEGRIFNGNPIRAKFWPKEKFDGGQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTK9</accession>
    <name>A0A1C1CTK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_08593</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTK9"/>
    <dbReference type="STRING" id="86049.A0A1C1CTK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08593"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06297"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF34">
        <property type="entry name" value="PR_SET DOMAIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="263"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT51819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="446" mass="47794" checksum="AF9E1F495CAD0434" modified="2016-11-02" version="1">MEVQTQPREARIFSILNDNDCPSFVIRPRQARQSSPTAESHRSTVSPPPRGERPSLLRHPKYDRESSVSSAGSPPALSRLSSSSKYSTSSMDSSPSPATPAYNFLDHTLAQYDPLLRQDPLAGGYLPSPTTITPFLEQQLLIGPNMPDQFSGKLMHPITANPYPIAPVPLHPTLQNLSTSSQPPNASVPPPATSAPANAQPRTSPTTSSAPTTGKKNKYPCPYAQSHHCQATFTTSGHAARHGKKHTGEKGVHCPICNKAFTRKDNMKQHERTHKGQSTSSSNSEDSTRKSKAAITKDAQKAKQLKKEHSANTEASRRSSLIHSPLSEVTSVAPTAIDTPLNVEESSMYADPTQVLMPIQTIPDNVSPSSLYPPLGDETLLNAAPLGQIPVLSKSHDPGSGAGGFMNPMPPLVRGLSDLDTLAQAAESFDASFYPAGLYPPPSQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTM1</accession>
    <name>A0A1C1CTM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NAD-dependent histone deacetylase SIR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SIR2</name>
        <name evidence="10" type="ORF">CLCR_08393</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTM1"/>
    <dbReference type="STRING" id="86049.A0A1C1CTM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08393"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06264"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="62"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="387"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="488"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="391"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT51853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="545" mass="60588" checksum="B31F842C9B385D1F" modified="2016-11-02" version="1">MASSAPQSPARRDGGSYFDTSPERPSPSKLLRLHHLFVDRAASLPPRRLSSPAKKTPQIRPRLNQYYTLDHAVSLFKSSRNIIVLTGAGISTSLGVPDFRSANGVYNLLVDSVYDDPQELFHIENFKADPEEFFKQAAKVFPKMQGLVPSNGTAAPPLVPKFSRTHAFIAMLQAKGKLLTNYTQNIDGLEVAAGVSQSKLIQCHGTLGTATCMSCGKRVTARKYMPVVQAGGVPYCKCSLEDGGPRPSTKTKHRGRTGRKKRKRDEYEDSDSEESNGRAGFPKGLLKPDMTFFGEEIADSYAPRLKLDKSKVDLLVIIGTSLKVEPVNEMLLNIPPTVPQIWISKDRCQREGVKVDIELLGECDLILEEIARRAGWEDALRERLWTGGKASEPKRSQPKPHSDRSHEINRPKRQEDGTSPVKPERPLQIRQKSTESPSLAMNPAPEVVVIKVNGEEIPPIAGAETAPNSTGQVIEVPLENPVEMKVENGYMSVKNDPSRENPVRHEKREDERPSLKQQTKSCPAPRVVVELEEGTRNRWYVRRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUK4</accession>
    <name>A0A1C1CUK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KOW motif domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUK4"/>
    <dbReference type="STRING" id="86049.A0A1C1CUK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08637"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05976"/>
    <dbReference type="eggNOG" id="ENOG502QUDZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="359154at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_uL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22682">
        <property type="entry name" value="Ribosomal_uL24m-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="393" mass="45217" checksum="44E4F275E02498B7" modified="2016-11-02" version="1">MQRVLRINLQSRNQALKAARRKNRDEYLKDWKDFESRQILTQKQKNEYIKAERKSRREDWMLGPLAPKRDVGTKQNFYGTVSNLLYQGPVFPPKVRRGPKGKGWDFVGGEGRPEEQKEWEGYGNEGNIVEGDRVVVVKGPTNLVGQIGKVKDVASDSKEVRIEGLNMADVEIPENFPDQRQKLHYTSLELPVPISDVRLVHRVTDERTGKDRDVVVKLLRGGAPYIQQPPNSPLPRHTRYIAGEDIQVPWPEVEVPSYQAYEGDTTRYDVESQTWTPTLYAPPVPPAAFDNLIEDEKYKRDRRWHDDEYVRMKVLEDARAEWYMERKIQGPLDTMVAEKIRQASQRTEAIKAAGMSEETKALIAEQMSRALAEGILQAQMKPLPQRKKVEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUM2</accession>
    <name>A0A1C1CUM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUM2"/>
    <dbReference type="STRING" id="86049.A0A1C1CUM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08997"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05963"/>
    <dbReference type="eggNOG" id="ENOG502S0WG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5358398at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048273">
        <property type="entry name" value="Luciferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Luciferase" evidence="2">
        <location>
            <begin position="170"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="266" mass="29832" checksum="997BD0D77C623745" modified="2016-11-02" version="1">MALLWAPNFFYVAVSILISSAIITYLLKFIRLDIRPFMSTKPGKIVESTATKICERMLNVLAVSDPLTPPTSPVTKSSRGYLETLPLRRGSRPEIEGISSPIQRTQLPPWEQKNVQDRLRNLIIEIPEKFPQSTYLGRSTFEPASPTSLYARHRAFNETKYYGEIISANTEDGFIHSSLHPSDVKMVIEKGWGQRHPLSGRLTARLTGLVDGNQPSPIAGSKVLLYAPRNNEDLEVIGQILTAAVWWVGGIDNRFDNEQVVGNTEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVB4</accession>
    <name>A0A1C1CVB4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10346"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03821"/>
    <dbReference type="OrthoDB" id="3211860at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="302" mass="34046" checksum="250C2E3347F916CA" modified="2016-11-02" version="1">MSCRRRDRANLIGCNIGDVALRGCCQGCCPYPDDEKFEHTHPYLLKGQFMPSTETSTTQHRNPDPRPMPSGRTNLRFRSCETPHRPKFICLSRSCRRLFKPFFDPARFDYRVDRNEWSVRPRWDVTPELRAAGRLNASALPPATRRRMHELRGRLDAIESQKQQHPRSSSGGGGGDDDDDAGGDGGDGKGDGDSLEPGPLSDDDLAWLRDHDPEVWWTRVVGVGHDHAKRCPGCGGSGVRVGSNFRVPARKDERAWKELERMVSQGVDMLAEFEFCPTVEVWEEMAREAERVKRKEASGEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVM6</accession>
    <name>A0A1C1CVM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Maleylacetate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVM6"/>
    <dbReference type="STRING" id="86049.A0A1C1CVM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10354"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03972"/>
    <dbReference type="eggNOG" id="KOG3857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08192">
        <property type="entry name" value="MAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF97">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE IRON-TYPE_GLYCEROL DEHYDROGENASE GLDA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="30"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="188"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="391" mass="42030" checksum="BFD4C0E250CB9353" modified="2016-11-02" version="1">MDSSLHPLQGLYRPNNLKGLYYGANVVKNHLLAALPTEKSKAFIITGSSLATKTPLIKSLEELLTPTHHAGTFSNIREHAPVAQLDQATETVKQDETIDTIISVGGGSPIDSAKAIAYRVNETSPDNKKWLLHIAIPTTLSAAECTAAAGYTRADGVKTGIAHPNTYPQYIFYDATFGLHTPPSLFLSTGFRALDHAVEAQYHPTATWIPCRLLALNAIGELFRLLPKYKADPTDQDTITGLFLAAYASLAFFGLNVRGPLGLSHQLGYALGSPYGIPHGITSCLTLGHVVKLMARRSAENAENVAAILPYTGAGQRSGDNLKDSDAVGDKILGLVQELGLKTNLTERGVGREQLDVICARATGGLTPEKEKTPQDEETLNAVRALVEKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVS1</accession>
    <name>A0A1C1CVS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isopenicillin N epimerase component 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cefD2</name>
        <name evidence="2" type="ORF">CLCR_10301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVS1"/>
    <dbReference type="STRING" id="86049.A0A1C1CVS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10301"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04033"/>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="383" mass="41469" checksum="81B161B586517B12" modified="2016-11-02" version="1">MATSPPPLTGLRVLELGGLAPGPFCGFLLANWGASVLRIDRPGPSGASNDLLTSHKASIALDLKNEASVAVLLSLIPKADVLIDPFRPGVLEKLGLDPEAVLLKKNPRLIVVRLTGFRRDGKYSTMAGHDINYLAVSGVLGMLGARGQPPLAPGNILADFAGGGHAAFTGVLLALIHRSTSGKGQVVEANMVDGVSYLGTFPRLLTKLPMWSGERGTNTLDGGAPYYGCYECKDPGRYMSVGALEPQFWQELLRGLGLTEQDVVPGRLDRLDKRAWPYMRELFTQRFKTKTRKEWEAIFDGTDACCVPVLEHAEMEVAGYEHRPIVGLTGSPARKVDMPWEGRALAPGEGGEDTLRDWMGWKKGTDYDVSAKGAFEKREKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW17</accession>
    <name>A0A1C1CW17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10998"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="134" mass="15036" checksum="F80A32EE0812C4CB" modified="2016-11-02" version="1">MPHEGSRALELCSRRVLSKPRAKASSVTRTNNHVERWSPGVRDQIFTNRPLTAHQNPTSSSTLSQIFSHVAQLQAPRPQITGQKAANDIRVSLSKTERSSLLRLQVERQKSAKLCAQDQDKTLIPHCPASRRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX27</accession>
    <name>A0A1C1CX27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WSC domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_10587</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX27"/>
    <dbReference type="STRING" id="86049.A0A1C1CX27"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10587"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04356"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651170" evidence="9">
        <location>
            <begin position="25"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="10">
        <location>
            <begin position="38"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT53016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="293" mass="30577" checksum="825593214C916CE0" modified="2016-11-02" version="1">MTRSILRAVALTSAFVLLASPVAAQDDSGATSTSAPKAITTLGCYNHPDPLKVQGNYDFQSSGYCQTQCVTMNKPVMAITGGSTCYCGDEIPALDQEVDQDKCNTVCAGYGLSTCGGIGYWQVYLTGLTGDVETAPNSTSSTSSSSAQGTAGSGSTSTQPAVVTQPGQTVVVTQSAAALASQDKSSGGSNKVAIAVGVVVGIVGLAGIIGGVLLYMRHKRNREIEEEHRRNAAVSSFVSSGASDKSSTDQRLDPSIYSHRRQSIGSIADERDFSRRILQVRNPDRESKQSTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX42</accession>
    <name>A0A1C1CX42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_09673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX42"/>
    <dbReference type="STRING" id="86049.A0A1C1CX42"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09673"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04366"/>
    <dbReference type="eggNOG" id="ENOG502SHMX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF17">
        <property type="entry name" value="SCFA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="282"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="609"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="735" mass="81677" checksum="80367B4062D56640" modified="2016-11-02" version="1">MHGPATDVAVKSSGAGATCESRLSAQSPSLKRKRSIHADAAGRAKAALPSPTSGYVPHRGLQEPSASHSPANHVQQPAASSHFDGPSPDATDVNRTSPEESHQYGANDSSMGFAKIVLGEDDESDSPATGTIPGDAGRSTTDTQFFPWIATPLPSLSILQVAVDAYFDRVNWYIMLFHQPSFTIRAQSILQRAAWRRDELVDVLLVATVASVGLRCVQHDKTWPGHRLLESYSVSAESLSSDLMAQIGSRFYEVMLESRIEAYQICMLLTTYHVYFGSSNFAWNVSGVSTRTAYALALHCDKTRNNNEIAREVSNRCWNHLVVSDQFSSMIFGRPAALDPAFAQLKKLKDLDDTTLPESTANLPIFQGHGAHISFLTYHTLKFELYHIIRQTLQSFRVMQLRSPVSVQDLRALIQVVNTTEIMLQQWHDHLPAVFKPSQWPAGNPWNVLELDQCTPEEQSVRKKIGLQGFILQLLYDAARVWAHRPLLKLRVALSPEADISKIPLVDVPDSLGTSVQAALRMSRVPIDEFGGHLAQSFALMHLFTAGIILCVAPTCQPYSQMAGDAKAGVLRIIAACRAIEDESKIARHTDQMLTRLYKKTMQREMDNALRNVDKGASRDRRSLPVSVKRSPDTGEDPQPRRAPALVSEPTSRTHVDMVSPTAATEYGGTISTFDSHVRRTDEPREEPVVSYLQFESLRHNDRMDPHDMEHLDEAYGAFEQMFNLDFAEFSFNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXY6</accession>
    <name>A0A1C1CXY6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AVL9/DENND6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_09918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXY6"/>
    <dbReference type="STRING" id="86049.A0A1C1CXY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09918"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00370"/>
    <dbReference type="eggNOG" id="KOG3823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651187" description="AVL9/DENND6 domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="AVL9/DENND6" evidence="3">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="529" mass="57904" checksum="C8DA8480EE6F1F47" modified="2016-11-02" version="1">MLFFGSKCERLCMMQFALVSLIPGLIANLQDAADPSLDSYAQNAQRAATLRTSDRNSLLAYMGLPLQIFGKGSFFGPYTPLQQLDILADYDTKSYVVGSTNSLLLQQKEKYSDILINLDESNSITMTSPSLRSALQLSAADRRWIDFLTQTVLDTWDPDNPSRPRNMGYAGSEDSIRMQFEEYILSLLSSMAYQIYHESLVTNAIPTNVANIPDHFPDPGDTAGDFNPEFLAMWRSTHNFELFDKLTSGNRIFDIIEPRHPTAGGLGVEDLQRRFAQGMAELHLDDRVREGREQLGRTLQSGRERVEAGLRGVWAEVERARQQRQAKRQSQSQSQSQTRTRAPETAEEDHTHTHTHTDKKDEKENHDPGAQRSTSLQAGTATGTGTGTTTSTGTGTTTLSHTNSDSDSSSIVVVDTDARRRPNNSPPESRSASGGGVWSALAIRDRAPKVDTAQIQASARESAVKAGAYFSSWGTWARERMQQQQQGAAKMSETPAFGRGEEAGGGGGDGGGGGGRTDDHNAGMEATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYJ5</accession>
    <name>A0A1C1CYJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative NADPH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_10287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYJ5"/>
    <dbReference type="STRING" id="86049.A0A1C1CYJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10287"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00567"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="7">
        <location>
            <begin position="47"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="423" mass="45788" checksum="E9AB9B0DBCFE3AE8" modified="2016-11-02" version="1">MTSLPSHDAKPLILNRGAPGISYYTPAQIPPSGTAKDPQSDGSPIPKLFQPLRIRGTTFQNRIFVSPMCQYSAQNGYLTDWHLTHLGGIIQRGPGLTIVEATSVSPEGRITPEDSGLWEDGQIAPLKRIVEFAHSQNQKIGIQLGHAGRKASTVAPWLSRGDTAQKEAGGWPDEVLAPSAIAFQDTYPSPKAVTIEDIQSIRSAFADAAKRAVEAGFDVIELHGAHGYLIHEFLSPVSNTRDDQYGGSFENRTRFAREAVEAIRAVIPKEMPLFFRISADDWLSGQKEYPESWTLDQTVKFAPILRDLGVDLLDVSSGGAHPAQKITGGPGYQAPFAHAVKKEVGESLLVGTVGSITSGVLAQELLEQGLDVALVGRFFQKNPGLVWLFAEELGVEITAAHQISWGFQGRIGGKDKHALKSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ63</accession>
    <name>A0A1C1CZ63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ63"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11021"/>
    <dbReference type="OrthoDB" id="10555871at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="124" mass="14133" checksum="BDCC0A35A7FA6C66" modified="2016-11-02" version="1">MKALVAVFRKFKTERHSLIELKLYASNHPIVWWNRFGNPTPAQVVMNHRELMHWNGNAKLLQEVARSGALKGWDVEKEVSVVACGNKVYSLPFGLVFKFTKPDDLDVLLAEGPRTVVYKPSILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZE3</accession>
    <name>A0A1C1CZE3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cryptochrome-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CRY1</name>
        <name evidence="8" type="ORF">CLCR_09696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZE3"/>
    <dbReference type="STRING" id="86049.A0A1C1CZE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09696"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00755"/>
    <dbReference type="eggNOG" id="KOG0133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="7">
        <location>
            <begin position="14"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="652"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="320"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="365"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="735" mass="82465" checksum="6843CFD56247A0B0" modified="2016-11-02" version="1">MAPRSSKQADRSGPRVLYWFRTDLRVHDSPALTHALSLAPSALIPLWTWDPHYVYRQRGGANRWAFLTECMGDLSQRLTNLNARQKLFVVRAAPRTVMRHLLERWRIDVLVFEQDTDPYAAMRDDEITRVAERCGVAVVSMPGRTLFDSREVVRMNGGRPTMSMAQLLKAAEKINGGVPARPLDAPTLLPDPLDAEAMDLTTLEDELDLLTRMDRIQDHSPVRASWPSAEGLDDYNAVQRTLGDGAPETQYSCGLMGPGRDFGVPTLQEMGMDPASVTTPHRGGETAALELLARHVANEEYVATFEKPATAPTAFEPPATTVLSPHMHFGSLSCRKFWWDVQAVIERRRKGHQPVSHQPVNLPGQLLFRDMYFAAHCQVGVSFGQQIGNPVARFIPWHLQSRHRRGAGGPDGELVITTTDGTYVVDDAKAEEYFQRWKHGRTGFPWIDALMRQLKQEGWIHHLGRHAVACFLTRGGCYVSWERGAEVFEEWLVDHEVACNAGNWMWLSCTAFFTQFYRCYSPVAFPKKWDPEGNFVRKYVPELQRFDKKYIYEPHKAPMADQKAWGCVVKGKGGGGNDGVDDDDDGEHSGHGHAIYPKPMFDFNERRQFCIDQMKKAYAVGLYGDDERVVNGEWKKLFDRDGDGGVAWREEANGDIARGEKRAREDGGAADHGDEDGDEDAMGEKVHVCSGGGGGEEETLDGRAAKRMAVKGRPATTGKQQRTLDSMVSRLRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZH2</accession>
    <name>A0A1C1CZH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZH2"/>
    <dbReference type="STRING" id="86049.A0A1C1CZH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10635"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00757"/>
    <dbReference type="eggNOG" id="ENOG502S97T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60858at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29446" checksum="F118AB34B43F32B5" modified="2016-11-02" version="1">MVATRHHPQPFPDPATPKATARSEATPSASSPQSDDSATISSTSRKRRAKRTTNSKTPTPSIHLYSHKVPPLLVIWLYVSLPLVIWDTGYIALRPHSMPGGKFHSPIWKLYALYGTVDYVYGWPAWNGHVGFTAAQASLNAVETAMYIYYFIAIYRNASGNLLATRSIQSFFLGEDENSVRGPGVAKAVLYLFSAAVMTFSKTVLYWLNEYFSGFANIGHNSAYNLVFLWIIPNGLWLVFPAYIMYLLGAEILEAMDGSSFAKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZY3</accession>
    <name>A0A1C1CZY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZY3"/>
    <dbReference type="STRING" id="86049.A0A1C1CZY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10371"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00908"/>
    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261121at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="347" mass="38933" checksum="A2BE8358716C59D8" modified="2016-11-02" version="1">MPNRFRFKIPLRSLRRPISPTKHAAVADPDPSRQGFTRANTKSNQNLKAQYNNGQAPSPVSQQAPPLPHMTNSPSIPSTFSEQNTYVEQPKKFLDERYAKCSVKGNFLTLAAQPKNVELGEWLAHQLVEMNRLLTGMIQVIQEVDTNVGLSLCNEQQCPTMSAGRLTYTWLENGRPAKIPAPQYIVRVQRWIVGKIHDEKTFPTSPPVPIDHTYLSGDIGTPGPATQVGVIAAPPTNLNQPLAALSGAQDDWVGKSSGFPQHYHADVKAIIKQMFRCYAHLYHNHFTDPFWHLGRSTELNSCFVHFCTVAMYYDLISKKDMEPLQDLIDIFVRQGVIPKEAVQQHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D008</accession>
    <name>A0A1C1D008_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D008"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00207"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02563"/>
    <dbReference type="OrthoDB" id="4158189at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="156" mass="17241" checksum="33B88244F7BA5C14" modified="2016-11-02" version="1">MCYQSKPRHTAAGDLIAILHRVHDDDWIQTAGNTCWCRLLLSNTCRGEILGELRCEEPRNTKKFLGQKLNVTVWTYATEHTQPVPAQRYQNPVFVRFALIAGAGPTVVNPDAGGGLDGVDRRDFDLTVADRGIVGREVDVANEQGKVLGRGIIGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D026</accession>
    <name>A0A1C1D026_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear protein localization protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NPL4</name>
        <name evidence="10" type="ORF">CLCR_09785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NPL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D026"/>
    <dbReference type="STRING" id="86049.A0A1C1D026"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09785"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00977"/>
    <dbReference type="eggNOG" id="KOG2834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="280"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT54078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="652" mass="73544" checksum="A615E5CCDBBC9E33" modified="2016-11-02" version="1">MLLRFESRLGQFRLNVEPTEQFSSLTSKVQILLIDGSSGLRLTRWQILDNLPPNTDADSIVLSNRPVGSKPDPERERRLADLPGVELQQVGLKHGDKLFIGFSEHEKLSNGHSNPEAPPASRRLNGTIALPEPTTLTPTVAVTSPTFIKNPWEVIKQSALDDRLDKKDGKISRPRDLKMCRHGPKGMCDYCQPLEPYDKKYLEERKIKHLSFHSYLRKINSATNKPELKSSYMPPLTEPYYRVKKDCPAGHPPWPEGICSKCQPSAISLQPQQFRMVDHVEFASADMVDKLIDFWRKSGSQRLGFLYGRYEEYTEVPLGVKAVVEAIYEPPQIGEIDGLRLLDWPNETEVDEVARLCGLERVGVIFTDLMPPEEGEGQAVCKRHIDSYFLSSLEIAFAARFQARYSRPSKWSETGRFGSNFVTCVVTGDEDESITIRAYQASNEAVEMVRADIVEPSADPSVMLVRSEDDESVTGQQRYIPEVFYRRINEYGANVQENANPSFPVEYLLVSLTAGMPINPRPLFTNSKFPVENREAVAEGQDPKDVSKQLRSSKSVEAVSDFHLLCFLHGMGVFSKEEEQILCRVATTRDQVDAAHLTESPGWGTLLAILESYGERPLKRSWNLSTEDDSFDPESPSENLAKRFKQAASLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D098</accession>
    <name>A0A1C1D098_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">epl1</name>
        <name evidence="10" type="ORF">CLCR_09876</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D098"/>
    <dbReference type="STRING" id="86049.A0A1C1D098"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09876"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00947"/>
    <dbReference type="eggNOG" id="KOG2261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="540"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="564"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT54050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="579" mass="65838" checksum="9DDAB4857717C0A3" modified="2016-11-02" version="1">MLRGRATRPKKLNSKQNVQIFREDQVESLPDYDTQRSAIETGVEKAEESEYHLQQAIKASEVAKADAKIKDAYIPTPPTIASDVKYDVLYPKGFQQPATYIRSSATVEDCAGVAYCMDEEDELALKLINGKLPAGQETCSEDQFEVVMNFFEETAQTKQPFAAVDSPPVLPLEELQDQIDDTVPPFVSNLSRFIYEHWRTRRTATGNRSLAPRLKFENGQETDDSDPYVCFRRRELRQIRKTRNRDAQSAEKLRKLRMELETARGMLLMVKRREQLRKETLEIDRLVFEQRLALRDTKRKLGVKGDEDLLINQKVWHCCSANGTITHLNSQKQKIPQGMTPNQAAIAQQLRMPMAPGPGPELRTLEDVAAVREREIQREIQTNIEKHIRWNEGFVDKTMAPLTPELEDDYPSPGEHFREAMAATEYLPTPPASISDEESQELPNGTDVVMKDVSRPSTPFRYASPADDETVSHMPSFRRRIGRGGRILIDRRLPRAGRDTLRGDDRWRYDSPDEDDFSDEERTFPDLTFARMSQRAYLIGSSRPSENTQLMAARKSQSEIAGPSHSSPVGHTQATPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0B6</accession>
    <name>A0A1C1D0B6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GrpE protein homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_00312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0B6"/>
    <dbReference type="STRING" id="86049.A0A1C1D0B6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00312"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09452"/>
    <dbReference type="eggNOG" id="KOG3003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT54207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="270" mass="30042" checksum="596EE1BA34FD9717" modified="2016-11-02" version="1">MFRRQVLRQSRSLSKSLSELAQAHHQRSPFSSATFLSPRASTYASTSLPSRLQQRRWQSSEPDKSKASADSAPPSTEESKPTDPKPEDALKEELEKTKREVIDLKDKYLRSVADYRNLQDRTRRDMESARQFAIQRFATDLLDSIDNLDRALSSVPPSALGKGQSSADSTAAAPSAGTAEAEPNKDLQNLFAGLKMTEEILLNTLQKHGLERFDPMENGGRKFDPNTDEATFFTKVEGKEDGDVFFTQSKGYKLNGRVVRAAKVGIVKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0M0</accession>
    <name>A0A1C1D0M0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0M0"/>
    <dbReference type="STRING" id="86049.A0A1C1D0M0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00995"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02916"/>
    <dbReference type="OrthoDB" id="3059356at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="119" mass="13174" checksum="5756CC2B4709B8D5" modified="2016-11-02" version="1">MLWSITTAHSEQGDATPPNVLGRDDDHSSRVHRLRGSRVRTHRSTSSVTSTSNGSTIPRLEAVVARVRSRPPIVPSNFTHELEHQKATVEDLVDFDGAEDPYWPVNWSGKKKIIAHGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0Y5</accession>
    <name>A0A1C1D0Y5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA excision repair protein ERCC-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERCC8</name>
        <name evidence="6" type="ORF">CLCR_00846</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0Y5"/>
    <dbReference type="STRING" id="86049.A0A1C1D0Y5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00846"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01634"/>
    <dbReference type="eggNOG" id="KOG4283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="215"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT54361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="511" mass="55684" checksum="D84B512E15C97B4F" modified="2016-11-02" version="1">MNQFRLGQSLGTVSSASFRRSHNETLIDSLAHQKNTTFAWARTQASEDEQDAASGSKRLPPYIAHQAGVNCLAIDHIEGRYLFSGGADSAIRLWDLEEHVQEQSSGSSTITKFTPKATLTKANLDSHTHALTTLSIYPFDPSPSTLLSTSYDKTLKVHSISPSSIAPVHTFQLDFTPHTHSISPLPSSPPLIAVGTAHPAIRLLDLRSGLSTHSLTGPNGAVYASAWSPKVSHILASGSTDGKVLFFDIRRANAAFASLDLDDAIGVIGTSSTQGLGARKDLLDFNAVAHNGPVTSIQWNALGDKIITSGHDQRIRVWDAACGRNDLVHFGPRIRNERQGELRPLLSPGAFHRPGQENLWWPNDDGKGTIFQHHLREGQLLKILRAEGVQIGDVQQNLKRVKVGASNLGRPTGGGRINAMVWRINAPTGEGVEMYTAHGDGRICMWLPSLVVEDEHDIEDEGRDMLTQPEIREAESTAVGIADEAEQKRKRKRDMLEDMLGGLSKQALRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0Z8</accession>
    <name>A0A1C1D0Z8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LSM domain-containing protein 1-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0Z8"/>
    <dbReference type="STRING" id="86049.A0A1C1D0Z8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00996"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01614"/>
    <dbReference type="eggNOG" id="KOG3168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="113" mass="12526" checksum="8ACBE847DA78D428" modified="2016-11-02" version="1">MEEGEAAQFLESLIGKTLYVTVPDGRLFSGTFRCTDNESNVILSNAFEYRMPSQTAEDAAVEKLKVQGQASRANMTSRFVGLIVIPGKQVAQMEVEERREWPGGQPLSVRTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D136</accession>
    <name>A0A1C1D136_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D136"/>
    <dbReference type="STRING" id="86049.A0A1C1D136"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00885"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01654"/>
    <dbReference type="eggNOG" id="ENOG502S0IF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5078320at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF2">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="2">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="387" mass="43366" checksum="0F70B529363E2280" modified="2016-11-02" version="1">MPKRTLFTNITPLPPQVSREVAIAMLHNHNEMIELNPLVIEHHPIKTPRDAPADEFLDCAWQELTDKIHFLPGGMMKGKVSYKACFHDMPNGLQTHIYAPMRLDIREKWTIGGSLPGEPPEPRELGLDVPREGLYIREDGDMKCNMLMTSFVRKNLDNAHKVLVERILKKAERVEETVKTMGMTPITPGPGSGSTRFQAGSHMSSSQIVNSPAIYNRPLSPQMLSPQQDLGWQTLANHPAFRNEDRRMSYHPVVHPQQRMSYYAPLKQPEPPKQFLAELPGSTFHTGHLAPPSRDSLVTNHRMSTMSELSGSDGGTHTGSPNSQAHSDPGSMVSENFYVQKLNAPGYPRDRPQSMVSGTSGHSSNYLDRMSMVSELPSTQPQQWPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D173</accession>
    <name>A0A1C1D173_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_00889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D173"/>
    <dbReference type="STRING" id="86049.A0A1C1D173"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00889"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01764"/>
    <dbReference type="eggNOG" id="ENOG502S329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2017317at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="78"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="367" mass="40892" checksum="F203A27CB25B8DDE" modified="2016-11-02" version="1">MQNTDGGQAPSSLQLWLDSFSLSGHRPPRTRAAESIPVTSQARQQQSLDDRPFSHLDETTTRIDDGDGKGDGDETVLYLGYGSNLSAETFRGKRGIRPVSQVNVVVPALSLTFDLPGIPYTEPCFGNVRRRDETLQSEDYHKDHWSKGLVGVVYEVTKEDFVHIIATEGGGSGYDDVLVDCFALSGEPSQDVPLKPAGQPFKAHTLFAPSKLSRPDHSYAQPSARYLKLITDGATEHGLPLEYQAFLRQIRPFRMTTTRQRLGSFVFLSVWSPFLLFLIGGAAAIFLQPDGTYPKWFAQFLNAMFTACWASYDHFFKELFGDGERTIGDDEDDDRYVSDGSVLDEKERLIERRGDKYGAVSTVEQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1Q3</accession>
    <name>A0A1C1D1Q3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRCA1 C Terminus (BRCT) domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1Q3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03067"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04727"/>
    <dbReference type="eggNOG" id="ENOG502SKU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="169"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="297" mass="32560" checksum="1DE41DA73F50DF03" modified="2016-11-02" version="1">MPTHRPRNPPLPSRTRTIFDPFNSSSTGHQRAENRLSGSTSWRDSRTHKLTHQLRDATGRGGQQHLSDLVGAGSEHFNKDGRKEQGDWEVGAPGLREEGWQDIRGLMHGSRKRLVEDNANAEPTPREKRSKLIDRRHEDTASDRENLPPESGKQANVDVASTSPSALQPPPQIFRNLRMYLNGSTAPLISDHQLKHLFAQHGGNTSIALGRRTVTHVILGSEHAVGGGLANGKIDKEVKLVRGLGKGVKYVTAQWVVDSVEKGVRQPESRYVPKGVEGRLGGSGQASIRGMFTPGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1X6</accession>
    <name>A0A1C1D1X6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_03161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1X6"/>
    <dbReference type="STRING" id="86049.A0A1C1D1X6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03161"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04829"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="3">
        <location>
            <begin position="73"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT54731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="158" mass="17343" checksum="6A62F5D2DA53117A" modified="2016-11-02" version="1">MSGQPESSSAGARKALHANANGPAPDYELPWLFTPPQRRVEKYRPVYLDDVVGNSETIERLKIIAKDGNMPHVIISGMPGIGKTTSILCLARTLLGDAYKEAVLELNASDERGIDVVRNRIKGFAQKKVTLPPGRHKLVILDEADRYAGRRPLRACAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D275</accession>
    <name>A0A1C1D275_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial protein Fmp25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D275"/>
    <dbReference type="STRING" id="86049.A0A1C1D275"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02825"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04908"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000027">
        <property type="entry name" value="Protein FMP25, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651210" evidence="3">
        <location>
            <begin position="26"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="313"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="377"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="459"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT54814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="623" mass="67935" checksum="D4F01BA7B4ABCA18" modified="2016-11-02" version="1">MTFSISEYVPRLALITWLLSPAIIAEQDAEEDVRGDDGLEQTEAIKQANNHVEEPSDFDAAHASQKATDPPSSPPRRGARRPGTQLLVAAAALALIYISTRSPAPAQAEAPAQDAPELLIEKSKKKKGVSKEENRDLISSQHLQVKKSWENPGVYVWGSNTGRVAAPESNETYIKTPRRLSWFDDVLLRDLKLDRTFGAAVLENGDLVQWGNAFSEDIRQPTVTLKGKDLTSIAISKDRIIGLSKNGTVYSVPVSKAEQESGHKQAEGSWVPFWSSTSAISYRKLEPKGLGAREKITAISGGLEHVLLLTSSGRVFSAASGTEDFPSRGQLGVPGVTWLTRPEGRYDMCHELTTLKGFDITKLATGDHHSLVLDKEGRVFAFGDNSSGQLGFDYNPEAPFVDTPSLLPTTRLYQGTNQTPRVTSIAAGGQNSFFTVEATRVVGPDEDQSSIPNLGKVTADTWTCGTGIKGTLGNGKWTHIQGTPTKIPALSSMFEYDEKARKVVPIRMAQISVGSTHASAVLDNVTYLNASEKSSEDDTNWGSDVLWWGGNEFYQLGTGKRNNNATPVYIKPLDMASEVEAGRKEEHRLHLTPMKNVNVKGRKVRMEQRVECGRNVTAVYSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D323</accession>
    <name>A0A1C1D323_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ypel3</name>
        <name evidence="6" type="ORF">CLCR_00028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000001">
        <property type="protein sequence ID" value="OCT55136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D323"/>
    <dbReference type="STRING" id="86049.A0A1C1D323"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00028"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00021"/>
    <dbReference type="eggNOG" id="KOG3399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT55136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="110" mass="12618" checksum="43C1399BCEB83816" modified="2016-11-02" version="1">MGLAYNVYLNSAKIFGCKNCKTHLADFDDIISRNFRGQHGKAFLFSTVVNIKQGEAMERNMTTGRHIVRDIKCKQCEETVGWKYDKAYEPAEKYKEGKMILESELLCVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6J4</accession>
    <name>A0A1C1C6J4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Emopamil binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_00700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6J4"/>
    <dbReference type="STRING" id="86049.A0A1C1C6J4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00700"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01088"/>
    <dbReference type="eggNOG" id="KOG4826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5415655at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF1">
        <property type="entry name" value="EMOPAMIL-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="8">
        <location>
            <begin position="48"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="262" mass="29228" checksum="E0739E5AC60A136E" modified="2016-11-02" version="1">MASAVVMAASPPFKLDAGTAFSLAVAFSLMPSAQVLAAYALPKSTPRKLYFLFLWHAYDFLTHFIIEGSYLYHCFFSYQQLPARTPDISHPAAWGGEPQAYLYNRPDRRYGAVYSQAPMARLWQEYAKADRRWGGADLTVISLEILTVGLAGPAAVYICYLIAKVTNSAEQALKARYLPALWFTAIALATGELYGGFMTFAPEWLSGNTALAGDDPVYLWLYLVFFNMLWVFIPLWVLYTAFVEISSAFKVATSMNAPKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6V6</accession>
    <name>A0A1C1C6V6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6V6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00588"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01125"/>
    <dbReference type="eggNOG" id="ENOG502T5F8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4154834at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="655" mass="73388" checksum="A5CA198A7F1F13C2" modified="2016-11-02" version="1">MATSKPVLFMDAKTPVNFQGKRQRQEVRALALRAASFSRPNRKKKKKDATGSEDSASTSSREASSSRRQRCPLPVTPPKDVTQPSDQRVRHCCFCGRPLEPSPKDVCPVSGNVQPSAPWHQICREHSPAAAATSAVARLHIRGPRPDTACDPFDSTPLAITADDHDVLNYIKSFTFAINWPDELEACREGHSLYNAHLLMYRRYFTHPAPMSGLLSYAYNLMALAQPERAAHHRQISMKYSLQCFKFLRDLIDTLDNSDEQLMVIVQTIFPLAIAEYSESIRKGGDRSLQHRGALLRLIQLLGGPQRLPLVYRELFVNFFAKSAIVRDTATEIDPAAWDPGPWQGQLGDAVPSLSSELSPPSKPITDTPDSLSEILAGLRELAIVGNIKRRGRWSDDDHLGPVFRWTYLRSMALKMRLWNFLHPTRCRSLSESLGSDTKPYHQISHYQSVEDYTRVSREFCLCLAAQLFIYLSLETCPVRHPTYSAPTQYADMLERSKILNTLLFGYADGCGTIRSLGVCGLDTTTMGEEQAHAQARDLLWIVAIGACFEEDASRQMPHNLIPGLAPTAKAAGFWDEKEWRVPLCADDGDDSGSGSGSTHQTARRWFSLHFGGLARRLGYLQFTRVKELFSSSYVYDEMIMEETLNRLFAVGLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6Y6</accession>
    <name>A0A1C1C6Y6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase iota</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6Y6"/>
    <dbReference type="STRING" id="86049.A0A1C1C6Y6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00641"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01154"/>
    <dbReference type="eggNOG" id="KOG2095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447129at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404:SF1">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="2">
        <location>
            <begin position="69"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="459" mass="51232" checksum="A48657EA6E414CEB" modified="2016-11-02" version="1">MVDYNMGLLNRHDLAHSFFCLSKDDPTIGFEYDASSFFGPTYPSKGTLQVSEQDEGLRLRLVLGSHLARHLRHELESQKGYTATVGIATNKLLSKLVGNVNKPKSQTTIVPPYHPVGDLEATVTQFLDGHDIGKIPGIGSKLAHKIRGYVLGRDAAFSEGLVYGATKESVTVLDVRTYPGMGPELLEEILGTTGSPRGIGGKVWELIHGIDDTEVGKAKRVPSQISQEDSYMKYLHTLDEVKKQLQLLGERLIRRMQMDLLEDEDDGPDPRRRWMAHPRTLRLSTRPRPLPGPDGVRARTFNRISRSAPMPNYVFNLNEPATALATRLVDEALIPMFRKLHHEKAGWNLSLINIAATNMAETAAESKDSAGRDIGRMFRRQDEVLKDFRITDEPNCATAVVPQKPPEQISSEAEDEAPVADGWDTDDSDHEAWERCESCQSIMPAYAFTAHRRFHELGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C771</accession>
    <name>A0A1C1C771_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C771"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06378"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07025"/>
    <dbReference type="OrthoDB" id="10436681at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="164" mass="19103" checksum="0C7C8F9CE14D918B" modified="2016-11-02" version="1">MITVLGVPIRAANATTIDQPTPTDLELLIALSNTVIWLLMGLLLYIQILDNRRVEARLVQQLEVERRTFAELNRERRELMQSWKQRLERIAEEDEPIEQKDGFDVVPEQTIIQDTGLHVEDDLLKAMEDELTEPREEEHEIGSEDDDGDDDRDDLEMVRMPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7A2</accession>
    <name>A0A1C1C7A2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-mRNA-splicing factor isy1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">isy1</name>
        <name evidence="8" type="ORF">CLCR_06206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Noorani M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7A2"/>
    <dbReference type="STRING" id="86049.A0A1C1C7A2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06206"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07053"/>
    <dbReference type="eggNOG" id="KOG3068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="272" mass="30521" checksum="9E550747DF8CC5BC" modified="2016-11-02" version="1">MARNSEKAQSMLFRFRAAQAAESGLLPSSSLRRPKAPSTINTVPLCEKWRGQILKEVSRKVTKIQDESLSDFQIRDLNDEINKLMKEKWGWERRIRELGGPNYMRGGGTVFDDQGREVPGGGKGYRYFGRARELPGVKEMFERAAKRRVRGGGGGDDDEDPAAKGPRQEINRRNLDARYFGFGADEEDAALLKYERRKEKEAVERLGKLAAAAATGTTAVEGGEGAVDDDDPDWEPLPGDAGDGVRWRLPTLEEVQQELMDRRRRQLLDKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7E6</accession>
    <name>A0A1C1C7E6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cpsf5</name>
        <name evidence="1" type="ORF">CLCR_06080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7E6"/>
    <dbReference type="STRING" id="86049.A0A1C1C7E6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06080"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07135"/>
    <dbReference type="eggNOG" id="KOG1689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT44453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="269" mass="30504" checksum="D4D6DEDF2BF5EC17" modified="2016-11-02" version="1">MSTLTTTTLNSSFPPILPAPFTANQPPTIRLYPLSNYTFGTKETQPEEDPSVVARLKRLEEHYDNYGMRRTCEGILVCHEHNHPHVLMLQIANAFFKLPGDYLPHDADEIEGFKQRLNERLAPTNPKEGDTEWEVGDCLAQWWRPNHETFLYPFLPAHVSRPKELKKLYLIHLPPNKVLSVPKNMKLLAVPLFELYDNTARYGPQLSAIPHYLSRYRFEYVDEEGKVASVMPGAGQLPGPDAKDAKVGVKVLADGDKEVTMEDTNTNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C864</accession>
    <name>A0A1C1C864_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C864"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05407"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07338"/>
    <dbReference type="eggNOG" id="ENOG502SV8I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2129362at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="957"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1063" mass="119347" checksum="8530457BE53624B4" modified="2016-11-02" version="1">MSFPYVGPSTMDNVTGMQGPSRLSPGSYRTAHASDRAGAVAHDRSHWTNAQEHWERIYSNRAMSFDPDAYGNPTAKKRDNSTNKGQSQLDRHPGWGIAQHPPASQWSSGIHGHSARGEGWTQGQGEEQMVEEEQGEEVTSLDVQPTEPQKVSTDGKVKRSEPTWFLSQDTAATVDSSVREFDKMAYGDPSRKKMTKTTTHPPTQRQSKLNSATPMAGRRNGWPEGEIASTAEPQSSPPLAHRPLPMSHVTLDASRNPPEPTDYNTPQPKMNGGQESRLRTTSSRNDPTKKSVTPRPETFETLKQGNETPEQLIARLQAEGTRDVFQRVKRKDQGEIPTTTGLALLDLLRKPLPPASDKPQPAASTTETQSKPLSNIDPGPSWNQSSQGPIRPTNHLLTEMKQANKDQRHWEQDMKNPALWEQAAIPHGNDTSSIQLQEPGPSRNTTDLQKTTGIWNESAVPSVSDGATWNEGGARPGNEVAVRLLHQSGQGNEHSWALRQNSDKAARRNSRWASAADMKAPKAKTDSNAEGSEEPESDGDSTRPMARGLGRLIRSRKPPVPEERLVGWDGQFLPPPTDWEYRPRFYNNTPDYISGFENWLGEVTVRTMSEKSVAELSFGVLPTEQVENLDNHPDGIGFAPRETVLGPSNSERYGHRLIKPIMPDPQNPTDFDGDAKLDLSDPDNARYKDETAQLYIARRMAQIKHVQMQAEEKARLQQEAGRQEQFDLGMDARAQEDDAAVVGESSKPRPPITTKNIYLRPAVQGDAPGMMEIINWYITHGFRPPELAPISEDDMLERMRMSQHARLPFIVAVERTRKTSRPKDRKYPRVNPNHPIQNIDPDYVGVTREEPIVGWASATDWSAPDYCECIAADLELYVAASSRKSGVGRCLMDAILDATDRGYMKKGGYEFRVAPEIKHMYSGGGGRDLHKLVFQVRSYNRPFTPEQMERIRRSAMGTPDMPLDRNASRWNRKPHSRAPTPGLCAEEREPPEKDFSKSARIDDREDDYEIWLKDWLESYGFEEEARLKMMGTKHGRFMDVRYLSRETCWQPSEGRIPDYTHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8R5</accession>
    <name>A0A1C1C8R5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_06039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8R5"/>
    <dbReference type="STRING" id="86049.A0A1C1C8R5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06039"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07549"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF28">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="360" mass="38566" checksum="5B3EE48CE3A71E33" modified="2016-11-02" version="1">MYHPDWVAKDWQLLLIFYAICLMTLVICAFANRFLPVVDTICAGWTALSIIIILIALSVKADVGRHSASYALGHYDKSFSGWGGFTFFIGLLPAAYTFSAIGMISAMAEECANPTVKVPTAISLCVPVGGTAGLFFILPICFTLPPLEDVIAAPYGQALPYIFRTVMGTPGGGLGLMFLVLTITMFCSISITVAASRCTWAFARDDAMPLANVWSRVDGRLGVPLYALILTTVVQMLLGLIYLGSSSAFLAFVSVGVIALAVSYAIPIAISVVHRRKEVSTARWNCGPIIGPIVNGVALCWISFEVVLFSMPSALPVTVVTMNYASVVFVGFMCISAVWYAVHARKVYKGPPESDGIAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C900</accession>
    <name>A0A1C1C900_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative WD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_06015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C900"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06015"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07687"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT45014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="363" mass="40355" checksum="F9667FC6AE501001" modified="2016-11-02" version="1">MAVPAQQKVHDVVRHYRPARIPTRADFYEQFPCSTRSDGHESRVTSLDFDDMGEFLVAASDDETMHVYDIKEGKRTKTIPSKKYGIHLARFTHHSRNVLFASTKQENSLRLLELHNESFVRYFTAHTGQVTCIALSPASDQFLSCGNDDMVCLWDLNSRSPQGKLKLVTPYLAAYDPSAQIMAIASQSTSSILLYDVRNFDKAPFATFDMLDAEDRYTPTTKGRAWTKLEFSNDGKHMLLGTDYHGHFVLDAFDGTVKSFLVGKTAGSGRAAPVSTSGKPLGQGDVCFTQDGRYVVGGTGESDLLVWDTQSTADIRLEPAARLNSRGIKTPVVQCNPRYNQLVTADTKVCMWLPGDQIKHADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9G4</accession>
    <name>A0A1C1C9G4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA ligase</fullName>
            <ecNumber evidence="16">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LIG4</name>
        <name evidence="21" type="ORF">CLCR_05402</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="16"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9G4"/>
    <dbReference type="STRING" id="86049.A0A1C1C9G4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05402"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07767"/>
    <dbReference type="eggNOG" id="KOG0966">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="151490at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17722">
        <property type="entry name" value="BRCT_DNA_ligase_IV_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000013">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000008">
        <property type="entry name" value="DNA ligase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021536">
        <property type="entry name" value="DNA_ligase_IV_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11411">
        <property type="entry name" value="DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 16 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="19">
        <location>
            <begin position="427"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="796"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="1033"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="559"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="748"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OCT45099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1116" mass="126916" checksum="9B5D495D0270B461" modified="2016-11-02" version="1">MSEDDSQYGFSQRSNAPRSREDIERQLDEEYPNRPRNHGKSRPFHSLFQELFNPLLDLRNKPKVAVVNRRKVGPDGQSNKSPSERRRDLIERYISRWRREVGPDFFPALRLIIPDKDRERGVYGLKEKIIAKLLIKIMKIDKNSEDGYNLLNWKNPGQTNTSHTAGNFAARCHDALSKRPMRTKVGDMTIDEVNEMLDELSAAPKEEDQLPILAEFYKRMNAEELKWLIQIILKEMKVGATERTFFALWHPDAESLFNVSSNLRRVCWELYDPNVRLDGDEAGVALMQCFQPMLALSKQEPLKKVVEALRPTPEDPKFWIEEKLDGERMQMHMVTDDSHPGGKRFQFWSRKAKDYTYLYGNGFQDPNGALTQSIKNCFRDGVDNIILDGEMITWDPNEKAPVPFGTLKTAALAEQRNPFAQGHRPVFRIFDILLLNGQPLTRYELRDRRKALAASINSAPERFEIHDYVVATKVEEVEDLLRQVVAEASEGLVLKNPRSMYLLDDRSGDWQKVKPEYMEGFGEDLDCVILGGYYGSGKRGGFLSSFLCGLRASRQDLEVASQQQSQSQSQSQSQHQRRKGSTHNLGGKAPPSQRQRHSQAENQSQSQSQSQALVPDSQPAQFEEDGPVENFTTFFKVGGGMTANDYAAIRHATDGKWHRWDSRRPAAADYIDQGDLSKLAEKPDMWIKPSDSVVVQVKAAQVTASTDYGFGYTLRFPRFVRIRRDRDWTTALSVNEFADLRAKAQDREEEKKLEVDQKRKDKRKARAGGYASRKRPLTVAGYNARDVNAAKLPEGPQGNVFEGLTFYIMTECSLPGDRKKSKLELEGLVKANGGRIVQQATPTSDDQDPVICVAARRTVKVASLEKHGQKEIIKPIWIFDCLDQANRDFALGFADQMVVPFEPERHLFFVPEEMKDRFEGNVDEYGDSYARDTSEDELREIMNKMGTVDIEEDEEKRIPDLFGDDFLNTKGFLFHGMVFYFDLDEDGPGKIAREARAAAAAQSMKSNATSMSGEDDEAFAESNSSSRLTTTSLKAIAKFAGAEVLSSEHGMLASVPPKLKSRITHIIAHRASEWSSLRKEVSRWNARKIPRIVTTEWMEVCWEDGTRVDEEAYVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9Q3</accession>
    <name>A0A1C1C9Q3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative microfibrillar-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9Q3"/>
    <dbReference type="STRING" id="86049.A0A1C1C9Q3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05785"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07830"/>
    <dbReference type="eggNOG" id="KOG1425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="145"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="524" mass="60509" checksum="DBCF4F890EB38804" modified="2016-11-02" version="1">MPPPMPNPAKRFTANPARPVGRYRPGKPVAEQESSDEEESEEEQPSQKPPQRRPQPSRPQPAKPQAQRQEESEDEDEEGFVTDDEDGTTATAPKVGTPQNKAPAIGSRSDTARQTDIKQESEDEEDESEDESEDESSEEDEEEESSEDDAPRRKFQRPTFIKKSDRNLSATPQASNATPDAITNGTPAPDSEMDTQARRLAQAELLIKDKLERDAIARAQGKKAWDDDDDVLPESMVDDTDGLDPEGEYQAWKLRELKRLKRDREALIAREKEIEEIERRRNLTAEEREKEDKEYLEKQKAEREENRHEASYLARYHHKGAFFQGNEAAEILKKRDVMGARFEDQVSDKSALPEYMRIRDMTKLGKKGRTRYTDMKNEDTGRFGEDVKRWRGSGGGSGVGRNGDSVMRGVDERFLPDDHRSGGTPGPTGANASVVASRRERGPDYERDREGDRDEYRDSYRSRDRSRDRREEGRRRDPDKDRRKRSYSRSRSRSRSPRRRKRDHSYERDPRERDDYRHRDGVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA26</accession>
    <name>A0A1C1CA26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA26"/>
    <dbReference type="STRING" id="86049.A0A1C1CA26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05757"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08014"/>
    <dbReference type="eggNOG" id="ENOG502SSYB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4154465at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="537" mass="61542" checksum="61498E6124CF8275" modified="2016-11-02" version="1">MFCFREGSDKHHAGRKLRGNRGKDPDRVARFPPHFHRGRHEHSTGKNDAPRQDADETPPGGRTSIASRKSRLDTRSVADELKDVEDRLFEWVTDHNLPIDQSQNAATFLLNKVFASHGFLQETNQRQVEKLRQRDIRLQRYETAITTRDEKILSLEQHIYAERAAAQHEKSQLYQEYQDQLQWERGNTERLKASHAEVVADLKRRQSECEKQHKAFVDSLVSDHQSRIHLLIQEHETENKRRGDEYSANIAREEEKVREAERAMCLSVDNFRGLQDAELEKRFYKLTTEIEGLSRLASAPDFAKQAEAMGLKIRPACTIPPQDHKFLFQSILWKIVMEGTFLTPFRVFGAYGDPIYQTWKALFGVRDQALPEWPEPDPLAEKWRYTTVDRLRIAQNALTGSHSQRQEIQASYQARISTLASALSGFFAFPSTTTNNNSPSLATRLHELLDQASEFAILIAIQRYRVRFFLPSTLGPRSQLDPKYVKGVYPGSELEVAYANAEFVVSPGLVKEGNSRGGKLEERVPLIKAVVYFNPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAU7</accession>
    <name>A0A1C1CAU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_01508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAU7"/>
    <dbReference type="STRING" id="86049.A0A1C1CAU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01508"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03578"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000061">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="103"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="566" mass="62123" checksum="53E2EE5DE3395013" modified="2016-11-02" version="1">MHPGQIPQANDAASDQNVMIPLAEDGAVEVAAQNVEEAEVPISKGVPGSPEPDDIEYRYLTFETDIPLTPVLPPDNKAELPPCPNLKDYDNPLAWSLTRKKLMTYLSCSVNIAAAYSAGSYASPTLQLTRKWGISAVAYKTGITIFTVGFGIAPMILAPFSEINGRRPVFVVTGLLFVICQICCAVTDSFAGMLLARLFLGVGGSTFSTMVGGILADIWLTADRNWAMVLFTGATLFGTGLGPLVSGFVAQRLLWRWVFWIQVMTSGTLVAMVTFFFRETRGSIILSRKAKMLNKWYEKLEEAGALGMAVDSTDPEKRMNRTCRIRWKVKADEERASLGKMIVVSLYRPITMLFTEPVVFWFSLWIAFSWAVLYLQFGSIPLVFEVSYGFSLEHTGLVFISMCVGAIISTILSIWQERWAAKHYPAKVNGSPEGRLMFTCIESALMPIGLFWFGWTCYPSIHWIVPTIAVGVATMGIFSIFLATFNYTADCYHIYASSALAASGLCRNLLGGSFPLVTNQLFTNLGFQAASSLLGGIGLALTLVPWVLVLYGPKIRARSKIASSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBI2</accession>
    <name>A0A1C1CBI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Mitochondrial chaperone BCS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_01416</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBI2"/>
    <dbReference type="STRING" id="86049.A0A1C1CBI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01416"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03714"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="63"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="302"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="369"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="624"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="747"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="747"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="790"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT45822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="847" mass="93170" checksum="D4885872F76677B5" modified="2016-11-02" version="1">MSSLPDFAQSHMAFYNQSLFNATSGPLRLPLTVLETVLPGTSLLAGFLLGFGVDASLLVSWIAVITAAWATMRFGLVAFIDSLLKAFTSCVVVEEYDPIYSHVLSWASAQKSLQNIRSLRTQTAGQYYDAFADGFDEDDNHQLQLRETMSEDLIFNFNSWAARAPPQYRPHSSSGWFLHDYRLFRVCRTRDRVASEIGFVYEKERLDILVLWLSPKPIKKLIEDAREFVLARRTSTTTIKRPTPKSQRNSRHQAWTTMASRPSRSMATVVLDNYQKAHILKDFNEFLHPRTARWYSNRGIPYRRGYLFHGPPGTGKTSLSFALAGVFGLDIYSFALSEATLTEEDLVLLFNSLPKRCILLLEDVDTAGLGRAPGTKRESKHASMNSSATTKDEQNKRGSLLHQDEEEEEIQSSAAPTGPTPNLPGAVAKEPTFKNTVTLSGLLNAIDGVASQEGRVLVMTTNHPERLDPALVRPGRVDLSIKFDLANRQQVKDLFMRMYCADTLEMTRQPTKISHILPNKVVHGDQDGQASSIGTDGGNEHRVHYDKESGSAPPLISQLAEEFANALPDRTFSPAEIQGFLLVRKGDPSQALSDVTAWRHDQLQKKLRQTTGAIDDCKVQPHGLKVKAESRSSASTWETSIGPGKVAESPAGAHVNGASPASGDASLRPLTRRTEVTKLRESSKLGNGTCTLPSATQSAKATINASANDASGLRTPPLTECRSDATTICETSRDLHAKTIANTGAHRLETHEPTSSPKHDLQDCPGSEVEAGEIDDEHTLNDGSTPSNDIDYDDQGINDGDGDGDGDDDDNYDYNNSDRRQITRAWFTPHGARGGSARTVFCPSHRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBK2</accession>
    <name>A0A1C1CBK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01436"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03735"/>
    <dbReference type="OrthoDB" id="4157699at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="730" mass="80599" checksum="E7F0C4F8C42F5D21" modified="2016-11-02" version="1">MTQRVKSTIPPPPMRVAEINRSNWTTPQDGLSNVNLKTKMGDNSVNGPNHSEEEGTKNAFEPYSSQSLRELRSAVSCAPVFDLGSEGIAMSKGKADASTETYPSRKQSISDLIQAIKTDPEIKRLLNDALAENKSPATNVTPGSLLGPPADFAQQVSTTETSAPEGFLSCETGTCQHAACALDNCDTCKFANGTSRQNEHAGDWQDVAESAATSAETWTPFQPIAPAFDSWTSCPTNRVVVKDVKYTIHDTIFDTMFPAYTRATKLDRLDDGSFLVSGIENKNFASALEFMYSQDMKHLRRIPVEGQHQIFAFAAECDNNCLLSMMMIILELDFSTPGFSHRAAEIYRSCGPMEEFRHYFRQTLKIELQSRLDDGTCEDFLSSVHFQFSGAENALLDVALALNSLWTTAELKAEHADRAEDWIDSGDGQKDADDHDNEDHTSSTCGENMIGPDYNDNWGVFPPKPYHWSSGWEMSSQSDGHPQPPCAATKSNLHTTKVPAPSIITPPANIVPKAPQQRNPSPGFTNWEEPIAQPLRAETSDWPMDTTQADWKATALQSTSALARCVHHHLKHRDIGTVTTVAEDLGCTKDEADRALQELMLVGVVNSVFRSGEPMGFHVKREMPQKPVTTASPANNVAETEEHERTRAAPLPLETVTDETRSVYHWLKGEQQGWLKEQWFSAEHVSDGTGCSFTKAILDLLELQSTGRAAVRRGPWGIPEFRLYSSELGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBT3</accession>
    <name>A0A1C1CBT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBT3"/>
    <dbReference type="STRING" id="86049.A0A1C1CBT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00391"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10009"/>
    <dbReference type="eggNOG" id="ENOG502SNSS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="227"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="695" mass="78123" checksum="407666DB19768EEA" modified="2016-11-02" version="1">MTELTPSTLCSACQLIFQESHASRSDSTGEIPHHGLEELASRASQCHLCLTVFMSIDPDAYRTFRSKGSAVDSVGFAWISPIARDQARLKFRYVKPARAPASVEENKENRGPTPSSNGSKASLALNWEETTGLVVELILMNPKYAVEPGVRTIDARSVSTASQETIELAKQWIQDCTFNHMKCSVSANPDASTWKPTHLLDVSVKGPRGVPGLKLVDGMFADPLSEYVTLSHCWGKTKTIRLHKGTLSALRQGVSLSSLPKTLAEAASVADRLGFRYLWIDALCIRQDSEADVLAAMGQMHRVYSEAALNIAATSSRDDAAGLINTRNVAALQPCIVSVNASLGVDEGMYKILRSTLWHDLVDASPLSKRAWAFQERCLAKRTLHFTRNEVFWECQQMCCSEVFPKGLPATMRPPSSQEHEEFFSKRIHHQRHGNWHQLVQMYSPKRLTYASDKLLALTGLAKQYMARNRLHADDYLVGMWKPQLPHALLWRVEQGRRPTRYRAPTWTWASIDGAVRYPEPATSQRETCIEIIDLDMAYHPAGDHFGIVESAKMKVRGFMARGLLRRTHDYWGRTPCVVQCTKAQVELENASFDDRLPKLSDAGSGMLCEMLEIYLLPVIDVVDRVEGLLLCATMKKGEFRRIGCFDVSTYDQVNWDRFRSVMKGDAEMNNYLERLDHANGYWFASDYTYTINVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCH7</accession>
    <name>A0A1C1CCH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylesterase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCH7"/>
    <dbReference type="STRING" id="86049.A0A1C1CCH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01136"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09348"/>
    <dbReference type="eggNOG" id="ENOG502SPY3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3946796at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="64368" checksum="46B30B81ABED9EA9" modified="2016-11-02" version="1">MRVTRAALRAQVQEEPQAQLIHEDADADSFHTSADSNANAEDLSRQPLKDITTETNPPGHEDPCTDESTLSLKKAKGKKKSRQPKKETVEANDTTPEELLPDVVDTPTEAHVALDSNSTPHHVAVEAPKTPKFNPAIHKPVEGIAASADDAVEDSFVEKITSRTPGRMLSSEGESKSPDSLVERITSRTSRIEDSVEAIDALEDAIEKIAETLPALEDLKMESPVKSRKNTPARINLPSEGPALRSAKKAGASPARTQRESLAKPRIAPKASDRPKPLVSRQSSVKSTVKSAVATKPVKKPILDGCKPRPTPARPAPPSLSFSTSPAKSLPNTTKKRVPSENLSTSKPPFVPTKSSKPPTKPTFQLPGEAISAKLKAHREERLKREEEAEKEKKVFKARPVPAKVARPSVVPRENKASQARMSIYANGINKENVAPKPATVSQPKPRPVSLDAKPKAADTTATKANSSVRRTTTTPSAAAQKPRVSSLILTTGQKSAITKDDVVHQKAKGKEVFGRTKAELERAEKERREKEEATRKARAAAAERGRQASREWAEKQKKKIAQQAQAKLLAAKASEGIEQQVGAGHDGTGTGTVAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCT7</accession>
    <name>A0A1C1CCT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCT7"/>
    <dbReference type="STRING" id="86049.A0A1C1CCT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01275"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09194"/>
    <dbReference type="eggNOG" id="ENOG502SV1F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="19"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="295" mass="32863" checksum="4A40CE3B9B3FFE56" modified="2016-11-02" version="1">MEQPEVDDEDEYEYEYDENETETFFVDIDLSSLNPGARPNDGAISMPRTVTPAKRKIDGSSTNTVNPDEPSPDTAGDPTGEARVTPMQEPQDTPAHVAASDQDRLQPFQSRVQILDLDSVNPIVSYQGEVYSCNWSDMVGTNMFFTYPETIDAAEALRSTDDYSLIGISRIKLVGHRAKIINRPTEGTEAVGDMKNGQPRDGNNALNSQSTDDGIREKQASFLEKLREITQRQREADVAQPPTNQEKHWANQGKSHEPDDVQVLERDADALVRVQESYSQSDADGPQSRETLQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCU4</accession>
    <name>A0A1C1CCU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCU4"/>
    <dbReference type="STRING" id="86049.A0A1C1CCU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01099"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09183"/>
    <dbReference type="eggNOG" id="ENOG502SBD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5360255at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004354">
        <property type="entry name" value="Meiotic_Rec114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03525">
        <property type="entry name" value="Meiotic_rec114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="678" mass="72914" checksum="47D04C10A959CBBF" modified="2016-11-02" version="1">MPSQGSQPLSQSSPLCLPLVKFSYATVSNDNIVPIPWIHLSSKNALFAVFETSPVQLEDGRTEDRQKFKVLKDPEVMEQLDLNALSAGAHRVLAQAPAVSSANIPIVAVIVKVPMIAIKYPLDNGQIRRFQIRFSKNEDYYEAMKMLARANIPTVEAGTFPSVKHQPAPKPPSVSLIAPEESASQVDGDNGGPRTYGINDGASSISGSRLASAGPSAMAPPQMFSAFTNRGEHRVMGQPPAISTMQTGLAPEPQPGYRIPHISLSTATTLVPGKQDSRSYPVEPRIRNPEGDLHQRESIPVAERQHGDFVAARLSHIPIPSREVIHALAPSRQETPIRPIGQGVSDHPHSLHATRSTTSRSQHCQEDVQLHEAGLAKPGSPTKTTGKAKRKRGAASNTKKAPAAKKPRAAAVPTRKGKTAPKKSPVPTVEELLQRPGYSLLPYESTAQARTLPRAQQSGRQQDGFSQMERPSAEIPESEHGAHNRVGVSSELGQVVSGCITRSASRALAAPRPNVLTKQGPTDVAAFEGAPPPCTPADQIMWYAATPASPTAQAHSTPLEARESRRGPTPSQDLPPVAVPAALSDLSLPVARQCMVHDENFDLLNADSRLEAWNNLAPATRLTALRSYFCGLILKEEFVDLVKSISSLWEGAILEGRVTRDLMTTARENAMDDGAGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDD0</accession>
    <name>A0A1C1CDD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDD0"/>
    <dbReference type="STRING" id="86049.A0A1C1CDD0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02184"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01191"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10397" checksum="A7784145749D8EF0" modified="2016-11-02" version="1">MAEATFRISLLPDDVRARVSSTCDITTPESVIEELVRNALDAEARSIVVEADFARGYIAVCDDGNGIKEVEFSQQGQLAKLHCTKAVQTHSEDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDG0</accession>
    <name>A0A1C1CDG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 4-coumarate--CoA ligase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">4cl1</name>
        <name evidence="5" type="ORF">CLCR_01890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDG0"/>
    <dbReference type="STRING" id="86049.A0A1C1CDG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01890"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01252"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="443"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="541" mass="59774" checksum="01DF7CBBFE08134F" modified="2016-11-02" version="1">MPIESAHPPITVPPVDVWDFLFEPSDREFPEDHVVFVDVAAQQQQSVRDVRDAATRFGRGMRQQWHWHKGDVLAMFSPNSTDIAAVTFGTLWAGGVVCPFNNLYTVGELASQLKSSQAKALVTHVACLEVAREAALLVGLSLDRVILVGSRDPKERFKHFSDVQASIADVQRVHVDPKEDLAYLVYSSGTTGLPKGVMLTHENIVANMLQAAVMDAQQMHWTKDSTVGFLPMYHIYGIAVLLLQPVFRGVRVYIMQRFELEPFCRLIQHHRITFACVVPPVVLALAKHPLVDKYNLSSLRMMHSSAAPLTADLVQMVYRRLKVPIKQGYGLSEASPGVASQSWSEWNKTVGSAGTLLPSISLKCVADGIEVPFGESGEIWIKGPNVFKGYYKNPQATAESISPDGWYRTGDVGHVDNDHNLHITDRVKELIKYNGFQVAPAQLEGLLLAHPAVNDVAVIGVYSREKATELPRAYVVAAKGYTAGPELEGALSAWLNNKVAPYKRLRGGIRFVDAIPKSNAGKVLRRVLSEQAKKKEESVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDJ0</accession>
    <name>A0A1C1CDJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">homoisocitrate dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LYS12</name>
        <name evidence="15" type="ORF">CLCR_01983</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:11900"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.87" evidence="12"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDJ0"/>
    <dbReference type="STRING" id="86049.A0A1C1CDJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01983"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01257"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047046">
        <property type="term" value="F:homoisocitrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000012">
        <property type="entry name" value="Homoisocitrate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF48">
        <property type="entry name" value="HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="14">
        <location>
            <begin position="8"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT46528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="369" mass="39386" checksum="576B42F1F8BE006C" modified="2016-11-02" version="1">MAAGRTLRIGLIPGDGIGREVIPAGKRILESLPSSLGLNFSFVDLDAGFECFKRTGTALPDKTVETLQKECDGALFGAVSSPTTKVAGYTSPIVALRKKLSLYANVRPCKTTASPAFKSPTPHPIDLVIVRENTEDLYVKEEKTYSDGEGGEIAEAIKRISSKASWRIANIAGEIALRRQKMRAQSQSQSQSSPTRNEGMVTITHKSNVLSQTDGLFRSTARQALSQEKFSSLRVEEQIVDSMVYKLFLQPEYYDVIVAPNLYGDLLSDGAAALVGSLGLVPSANVGEGIVIGEPCHGSAPDIEGKGIANPIATIRSVGVMLEFLDLPDAAQAVYKAVDGSLGEGKFVSPDLGGKASTQEVLEDVVKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE96</accession>
    <name>A0A1C1CE96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">8-amino-7-oxononanoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bioF</name>
        <name evidence="6" type="ORF">CLCR_01952</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE96"/>
    <dbReference type="STRING" id="86049.A0A1C1CE96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01952"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01508"/>
    <dbReference type="eggNOG" id="KOG1359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="34"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="436" mass="47638" checksum="277FF39580CD8FEA" modified="2016-11-02" version="1">MSPSPLERRLSGLLEKRRAQSKLRNLKSSPPGSVDFSSNDFLSLSSNKEFQDDYLALLSKGRTPLGSTGSRLLDGNSELAESLEREIAAFHGAEAGLLTNSGFDANVSIFAFLPQQGDVIIYDELIHASVHDGMRQCRAKQQIPFKHNDVEDLSRILQQFSSSSPNQTIFVALETVYSMEGDLAPLTEIVDLVEAILPHNNAHLVVDEAHATGIYGPNGSGRVCELGLEKRVSIRLHTFGKALASNGAIILSSPIIRLYLINYARPLIYTTFMSHPNLLAIKNAYDWLRVGKANFLAANLYHLIDHLYARLQSLTALASSIADPTGKPVVTLPTTCPESPIFAILSPQPRSLASHCQSAGFIVRPVVAPTVPAGTERVRVCLHAGNTVAQIDKFVECLKRWITNQGAINQAGMDYPAEQYGRAGEETSERRLLAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEJ2</accession>
    <name>A0A1C1CEJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_01933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEJ2"/>
    <dbReference type="STRING" id="86049.A0A1C1CEJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01933"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01585"/>
    <dbReference type="eggNOG" id="ENOG502QPP7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT46876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="525" mass="57815" checksum="EF94117B5DC4DC0C" modified="2016-11-02" version="1">MEINGSSGASAGGPWTPSSWKTRPIVQSVTYNDTHSFDSSLQKLNKLPPLVTPREIVKLKNELREVARGNAFLLQGGDCAELFDYCTQDMIEAKVKLLLQMSLVLIYGAKKKVVRVARMAGQYAKPRSSPMEVVNGVSMPSFRGDILNSYEADPALREPDPRRLVDAYFHSAATQNYLRAALTSGLADLHAPLDWSLGHVRDPSVRDNYQVIVERITDTLEMMRTIGLDTGGGLETVDLFTSHEGLLLEYEQALTRQFKHPTNYHQQQQQQQRDVPRPVSPVAQQPPKSRKTSLPTQLPPPLPPTRGYYDTSAHMVWVGDRTRQLTHAHVEFFRGIANPIGVKVGPSMPPSDLVPLLDILNPGCEVGKIVLITRYGCDKIAAHLPGHIRAVQNSRHQGTVVWQCDPMHGNGRNATVTMPPDSTINGSTAGGSGSTTIKTRRFSDILSELHQALQIHRSHGSYLGGMHLELTGEAVTECVGGAEELTEQDLSLNYATFCDPRLNEKQALELAFLVAGFYRDVSGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CES3</accession>
    <name>A0A1C1CES3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mannosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CES3"/>
    <dbReference type="STRING" id="86049.A0A1C1CES3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02422"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02471"/>
    <dbReference type="eggNOG" id="KOG2515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="56507" checksum="542BAD0A022F1E4F" modified="2016-11-02" version="1">MDSETIKRRVSDLIARSQPYVDQAREHIRPYTDQAKEHVRPFLDEATAQFQRTKHHCSSALSSAQTDFYRLSQQPHFKEIASGLILLLFLTVTITRYISYRHPRTPSRPSTPSTPRLEKANHTSPPQSTRKPGTWPPSTFVRPKPPPYENWSIERTKPLPYRPFRYGPKYFQTMGLRNIKWDDWIELDNHFPRYHGDKTRRIKERGHKCCRTHPDAYPAALELLEELRSYLPDRYPSLYARTDKGIKNLWSGEELDTTSDPLPEDPMQTAARLVQDDLAIMIERPDGQYYLLAGAILLAGFWRLEDKYGMPLSEIHTSGDVPQYREKLEKGMMNFFRRLKPEELVARNNYFLQVDEDLAWSYSIGSEDRPHISWNTAEKNRAIEHHYFRSERQSLRRLPKSGGVVFTIRTYFHPITEVAQEDYVPGRLASAVRSWGDDVSRYKGKEKYEAVLLEYLDKKHQEQLDRGLKLEEEDEKRSYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFE0</accession>
    <name>A0A1C1CFE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02693"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02243"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="90" mass="10233" checksum="A79D7F5213679BE1" modified="2016-11-02" version="1">MLPQGQQQQMTTVPTPDTVPSFPTRQQAICVFTSPETGISYTKQELDEWSRGKLNDQGDKVYFKPGFVDADPWSRLRGVGETKDNNERQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFF3</accession>
    <name>A0A1C1CFF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serum paraoxonase arylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02438"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02185"/>
    <dbReference type="eggNOG" id="ENOG502RYG9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF20">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="428" mass="46431" checksum="D1326D702CE64B37" modified="2016-11-02" version="1">MANKPALLAILFGFGAIFWQLVLRDAIYNGAGLGRKVQPISDFPYRCHRISGDPNIQACEDMWLDQKSRTLYLACSDSLARKQWMPNIHRLNVSGRALNDHVVAMDIDHPNGQGGYTYSVLKTPGFPGVHGDGRMHVVGMTGTTSADGSKTQVWLVNAKPSVNTQTGELLDNAVAGANSTIEVFEIRPGSDSMVHLRTYADSQIATPNNVAVVEDGGFFFTNDHGPHKAGWQHHLSSFIGTGDVSYCSSAGACKKVAHGFKFPNGLHFSSDGLLYVPSAAIGGITVFRPKPDGSVLRVHFIDLDYPIDNLSEDSIGDIYAAALPKGMQALAAFEDPLNPKSAPAAVWRIRRLNRDVADTYKYELTKVIEDAEGVLLPGTTTCVHDAKTGRLFLSGELSRRDEILVLSYVTQLTPAGVVSPFITVCERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG78</accession>
    <name>A0A1C1CG78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vanillin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vdh</name>
        <name evidence="5" type="ORF">CLCR_03468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG78"/>
    <dbReference type="STRING" id="86049.A0A1C1CG78"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03468"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01875"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07105">
        <property type="entry name" value="ALDH_SaliADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000010">
        <property type="entry name" value="Gamma-aminobutyraldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT47508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="489" mass="52622" checksum="CF1108B30FEC5A89" modified="2016-11-02" version="1">MSANGANGTHSSAPAFDVSATIPLWLDGKEVKLSSTFDVVSPLDQKTLYKCSSADEEDVQKAIAAAEKAFKSWSKTKPNYRRDIFLRAADEFKRRRDELQHYSYSETGAAASMFAFEHNLAYEACKSVAGLIQVATTSSAPVVSEEGANALLIKEPHGVVLGIAPWNAPYVLGLRACLQPLAMGNTVILKGPEAAPATYWAISSILHNAGLPAGCLNTIYHRPADAAKVTSALISSPSIRKVNFTGSTAVGAIIASQAGKFLKPVVMELGGKAPSIVCEDANIQTAALQCALGAFLHAGQICMATERILVNRKIADEFREALKKTVEQVFADTPQLVTSAPVVKNKKLLEDAISKGANVVFGDPKHNDESPTKMKPVIIENVNEKMDIYHTESFGPTVSIYIVEDDEEAIRIANDTEYGLASAVFTEDLKRGLSLARQIESGAVHINSMSIHDEPALPHGGVKKSGFGRFNGLPGLEEWVRTKVVTWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG94</accession>
    <name>A0A1C1CG94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative chitin synthase activator (Chs3)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG94"/>
    <dbReference type="STRING" id="86049.A0A1C1CG94"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03306"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01842"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4095816at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF2">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="833" mass="89900" checksum="0DE4F0BE26FFE41A" modified="2016-11-02" version="1">MDYRTGATFVPGGDDSYYLPELIQPTPNRVHELPDNMQYNVAQMEQAASDPYSASSAYSSSVYSPQSAVHQSGVNSWTAPQPPHTQHQGYGQNVPTNNHNPAPPTQANNFPPRSASIAQVPEQPNFSPFPVLHNPPPNVPPTDEQKEATLEAARAAVLSCNDPDTQLTWAQDALAYVEVAQQNEARIALAQTPRSRTPRIEHVLKEDALKIVSFLADQHHPRAEFMRGMWLEFGKFGHRVDKKEAFYCYTRASEKGYIRADYRIGMQFESSNDALKAIKYYQKGAEAGDSAACYRLGMMTLLGQHGQVQDYERGLNLIYMAAQTADENAPQGAYIFGMLQAQQMPQIQVPDQYLPRDIPGAKINIEKAAYLGFAKAQIKMGSAYELAELGCPFDPALSLHYNVLAARQGEPEAELAISKWMLCGHEGLFEKNEELAFTYAQRAALAGFPTAQFAMGYYYEVGIYVPVNFEQAKEWYRKASQNGNTDATGRVDAISRSKTLSRKDHESIALKKIRQQRGSIIGESEVPPVPTMPTLSEENESLEMPDPSRMSLNNLRPPSARPASAAPYPTGPANMPALNQGPDFRPTSAFGINPNLRPQSAANTGGPRPDHYGSLPNTVHQQHPYSNPPPGQAYGAPGYGRGGRVPSGPPPQGQGVPSNRPPARPGTASPYLGSGPRPGGPGTSPPAKLDIGYSAPPEPERRRPVQQPNGPSPSNPNNPPRGSPRPQQGPPSHNRPGPQDSRPGAGPNTGGYGGMPNANVRPPVQVQVPPNVRPVNMAPSRPDSSAPIGGAPPSKPAPVPANAAPVRPPGKGPKTFDEMGVPAGKDKSECAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGI8</accession>
    <name>A0A1C1CGI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_11273</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGI8"/>
    <dbReference type="STRING" id="86049.A0A1C1CGI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11273"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01794"/>
    <dbReference type="eggNOG" id="KOG4245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF30">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="78"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT47592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="390" mass="43913" checksum="C1AC77C084725FA9" modified="2016-11-02" version="1">MASKVPLITLEEHFISQAVVDYYKSRGIETSLPDTMSHIMTSLREVGPKRLQAMDNGRVSLQVISHRPNTIPVPPDVCTAANNELYQAINSSPSPDRFAAFAMLPMLHPEEAVKELDRCVSELKFVGSLVDNTANGRFYDDQFFWPIFAAHEKLDVPVYLHAIPQPITESTPSPEFHGNYSANVSNFLANHGFHWHSEVALHVMRLFASKLFDRHRHLKLLLGHMGETLPFLIDRIHKLVQKTWPPESKPRRHLLQVWHENIYITTAGMFSLAPMACLIHMCCADKVLYSVDYPFCAHEDGVKFMHALHGSGMINDQDFEAIAYKNAERLLDVRVPDGNEIGLEVDGDESGGEGDRRRMPWLTAVDSSNSVNGDGSAFPHSPLDTVHEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGR8</accession>
    <name>A0A1C1CGR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidoreductase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGR8"/>
    <dbReference type="STRING" id="86049.A0A1C1CGR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03434"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10387"/>
    <dbReference type="eggNOG" id="ENOG502SD1F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10003116at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="59845" checksum="27B2F6F8F72D73AC" modified="2016-11-02" version="1">MNAPVEAQSISSLSYLLANPPRYPRNPTHQVHDPLVLYIVRVPGSKDVFLTTLKPPTKATISIEAVQSSLYFLHVERPQDEALRDSLEAARAAERSSNGVSPIRRKPLPSTPFANYPASQRPPTPPKSYPHYQPPLPGSGTATQAQRYAARGANLRLDMGDPNPGSATSRRPVGARPFPARPALDLPLQTISDEDSASPDPIEQGRRQFRLARKPVQGPHLLHAGAPENVEPEQELPTRSPIPLPSQPSPTNLAGNVVSRPQADFPRVTLIRRDPASGSQWNVGSIIPHSAGGPLHEVEIELTSPGYTHFAELDAASGRGFRRKVGYLSTSNQDTPLVTRRRSNSDESVATSPFSNNRKARRAYAFMSPWHGICAFSNGLDGKSLRCRQTLLGANPSIAGVTADVAELRFNLPWATNRLREPHKRQGSELSELSSNVPVARPESSSSREQWRRSFQALTHKARKQLSISDNNDDWKSPREESPQLDRLENGSRMSLDLGREKAGGGFTGQSAKLGKLIIHDEGLKMCDLVVAACMGVWWQHYAGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHM8</accession>
    <name>A0A1C1CHM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04345"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08184"/>
    <dbReference type="eggNOG" id="KOG4781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="106"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="236" mass="25250" checksum="945EAA9B8A3A8F2C" modified="2016-11-02" version="1">MPTTDPAYFRAVPWCAALLSDPEYIVVPSRFGRPMKDGRGEFFTKTLATDTTITACICQTRRADRNNNGHQNSAAETTATASVPQATVSEVRAFLSTGPGVNGHPGIAHGGFVAAIIDEIMGFLINSNSATTETAGIPPDGSAQPVHPHQQPVPMTVPSAISIMTAELTTKYRRPVPTGVPLLVRTWIEKTEGRKIFVRATVEAEDRQILTEGVGLFVALKPGTRASAARRTNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHN2</accession>
    <name>A0A1C1CHN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04471"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08109"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="83" mass="8981" checksum="A94FBC696B9E0427" modified="2016-11-02" version="1">MPSTNEKSTIAAETASIRSTSTTSSLKALLPRKASKGSKAAKDTKDTKDVSKGKPLTVSVRETPEERATRREAVAGYMSMMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHR8</accession>
    <name>A0A1C1CHR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit ASK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CLCR_04104</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex ASK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHR8"/>
    <dbReference type="STRING" id="86049.A0A1C1CHR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04104"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08233"/>
    <dbReference type="eggNOG" id="ENOG502RZQN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5573898at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013964">
        <property type="entry name" value="DASH_Ask1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08655">
        <property type="entry name" value="DASH_Ask1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="83"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="271"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="124"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT48074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="435" mass="48124" checksum="565391BF15F055AE" modified="2016-11-02" version="1">MSRASSTAPSRALTLTEELEKLEQSITLTLQEIDHNFSRAHRIVTSSILPIVEQYAAHSKDVWEASRFWKQFFESSANVSLSGYEEQASRLDTTDDADITVTEDSNTTTHTTLETSESYETPSAQHISTDSIQDLDLSNMTISPSKSSTPRPYRTQNAQQPQASFAHYPSPYEALREEVNNTMADSTLHTRATEPETPGGQPVFHVDTMAATPQSSPFLPPRPTSIPRPSTTRKKTDPLLHRVLDRNYRVQATPLTSQRYSNLQLGTVATPSQTSRAGKAGFNDSTFDSSPEVAPPELNQEIFSSPERKRPIPGVSVLTPARARSKAQTLGEATRTLGPWDSDDDDLDDDIPFGQSPPKTMQFHIPQNRLLKTPAKEASKRIVEDILTNAGIDYGEEELDFSQTLETDGSDIDLGVEPTSPSVVRRAMNVEDETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHR9</accession>
    <name>A0A1C1CHR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_04088</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04088"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08167"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2587356at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="62"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT48002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="406" mass="43522" checksum="324FF74502A7ED70" modified="2016-11-02" version="1">MDETQANRDHEQVVPAHTMEKPTGEHHETTVEHVKEVNAAIARTDSHLDVAHAPLGWRSWLVVLVTMFGNLTLVFVVVAAGSVIAFIIRDIGEPGLAGWIIQIQGPLLVQSVLCPIVGRLSDVIDRKYIASFQLTVAFVGSIVSARAESMNTLIGGGILIGVGLSSLGIIVAIPAEVLPLKYRAIANGANFLGGAFGGLVGQLGAGAVTNADKGGWRNIFWMQAAFHGATVLMLLAFYHPPRRSDYPKMKVAEYLWSLDPVGAMLFIGGATLIILALDWTGGTYPWRDAHVIAPLVVGIVLLIFFGFYEWKGRSDGIVAHVMFKKGYNFPLAVFAFAVEGFVLFHMSGASANVDQMDFLQRGQFCNSTGHTQPRVGVDVVADRHSPTGLPASGDLLLNPHGVGGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI18</accession>
    <name>A0A1C1CI18_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI18"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04408"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="151" mass="16482" checksum="92BDA930611D5675" modified="2016-11-02" version="1">MSAGNHQTPPVHPPDSRYCMLPSQAPGLNELRAHQDLLSPNLAVSSGLTTADTRLMGKSPLVVMLCEQGVRSARLVTTSTSQLPETQITRVGVYVSKNMSALVPFCLSPESDCCSRERSLGRPRDGPVLRRTDWSTVMQSSHTIKFAFQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI83</accession>
    <name>A0A1C1CI83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI83"/>
    <dbReference type="STRING" id="86049.A0A1C1CI83"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11299"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="94" mass="9794" checksum="0F5504D1C6A5B785" modified="2016-11-02" version="1">MAHKGNTDKGNTDKGNTDKGNTDKGNTDKGNTDKGNTDKGNTDKGNTDKGNTDKGNTDKGNTDKGNTDKGNTDKGTTDNDNSTRTLAYLALLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CID9</accession>
    <name>A0A1C1CID9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CID9"/>
    <dbReference type="STRING" id="86049.A0A1C1CID9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04395"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08382"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="75" mass="8504" checksum="7AF368D7BE159938" modified="2016-11-02" version="1">MYTTLSPCDMCTGACILYKVARVVIGENKTFVGGEKYLQERGVDVVVLESKECMELMAKFIQEKPHVWNEDIGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIN5</accession>
    <name>A0A1C1CIN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04461"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="91" mass="10084" checksum="62C050D842FAAA77" modified="2016-11-02" version="1">MAFSKRPNLVHHLTPSKDIQFPAYATFHRGISKARRNEASSIAKGMCNELIAIIRASCREDDCVEVVIPGLKALDKGKIFTFVRRAGIVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIN6</accession>
    <name>A0A1C1CIN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_04243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04243"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08471"/>
    <dbReference type="eggNOG" id="ENOG502RZ7A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412109at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="333" mass="39749" checksum="EBACC8F1CB7218D9" modified="2016-11-02" version="1">MPSEAATDEPVVEPGPADERSKRFRFKSKSEDDHRSEASSRSHKRRKHHHSSHGDRKRQRSSRHSHDANHAQDYDSSHLPPDQAFRESLFDAMGDDEGAAFWENVYGQPIHSYPNTYRDEETGELERMTDEEYAQFVRRKMWEKSWEGIEAAKEEKRKECEREKRRIREEETRRERARQARHGDCIFDIEIENSLRRGEKRKDRRRWQRLWEDYLRRWEDLQSLAQNQQKSGEDAEQVFLRDKIAWPVETGKRKDVVREEIESFVKKGTSGYEAVDGTDPFAHAIKTERVRWHPDKIQQRYGFMDIDENTLQGVTAAFQVFDDIWNEIRNRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ21</accession>
    <name>A0A1C1CJ21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ21"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04343"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08568"/>
    <dbReference type="eggNOG" id="ENOG502TK1D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4153234at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650844" description="Secreted protein" evidence="1">
        <location>
            <begin position="37"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24708" checksum="0F8065B6344E3C7C" modified="2016-11-02" version="1">MCLSDSKRPVLQSILRLHSVVLVCFMLAFCFNVVSAESDQTILNGRDVLNFDDLETPDGFGHIAAGYHGLTFNYFYAFQPTHQDLEGIISVDDLNCAVSKPNSLYGSKIAAESPSIQAHDPSHRFTVHSLKIKPLDFPVGFVTINLRGFLPERLSSPLEWSVDFPAGFHDTLHVRLEEFSKVRWQGLARLEVEADFHFNDVEMDDWEFCIDDLEVEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ36</accession>
    <name>A0A1C1CJ36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein NO VEIN C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ36"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ36"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03794"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10310"/>
    <dbReference type="eggNOG" id="ENOG502QQIR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052957">
        <property type="entry name" value="Auxin_embryo_med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387:SF0">
        <property type="entry name" value="PROTEIN NO VEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387">
        <property type="entry name" value="WU:FJ29H11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1342"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1355"/>
            <end position="1371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1651" mass="187504" checksum="5962BF0407247DEB" modified="2016-11-02" version="1">MPKPGFNGNGRPLNVAAARDEINRIRRDRGIIDDYDESQIRKTDSSFQEDYRRRAAEHRAFVAEQLYSSRFRLIYELLQNGDDSSYANDVEPSITFRIKPSELIIESNELGFTLENVESICDTGKSSKASNADTTGEKGLGFKSVFGIADYVHIQSGLWSFRFEHSQGEEGVGMITPVWTDVASLLPSNVGTRLTLRYHDRRDIFATRLVSEFEKLPRTIMFALRQLKKLVVVVDGVAGRSDRMTFEKGGDLRSDEIRIIATVTGNFGAHTSATTWLRLFQYTVRDLPSDTHRTSSESDVTVAFEVDSDGLPVIPTNGQHVFAYLPVQRIIQLPFLINANFILTANRESVPDTDWNNALRVGVSRAFVGLVDKIVTSGDPLEFTWMRYLPQKPTQGFWEWLWADIQAELSYRALPILRSRRDELHSIEHMTTLPDWFIHENEPIVADTDEDVYLSDDYESSDVRILEDLGVRQISVTQILERIHLGLSQSAERPIHHIPLDDPWHTAFAALIQRLLGRKSIKKDVERLRIIPLDDNRWVSPLSLRVDAVYLPYLVDEDSVSIKVPDGLGFNKLHETAAADGERASFYTSLGITSCHPDAVTASILEMHQSWTRTGTMFTFKTDLEILFWFGKRPSLSTQSQMRLLLVSDENKLLQGPFVFFPSEDNYHAEKLLAATPKEDVHKCRYGILDKEYLNSQVSNHIRHGLDWRSYFQRWGVKYFPDLVREVSAGWKLHSLMELIARDNPDSFVANLKAHWSDYRVDASRIKNDLKNVRVPCLNDSTQRLCDTILPTHELMDRSRDPNLTNLLPFLKLPRDYVTQQSEAWYFLKEFGVICEVNASFYLRAMYLLADLGEGHLLPTCEKIYSGIAQTTAIGDAKAVQQEFTTRPMIRSKTTEEAWYRSTDCIWEGPSFLQAKQVLSPLYGANQSASSFFKTILNIRDVSYNDLIDELKMLSTKAAAGSPLIESKAPKVYAALDAMASSEPVIEAIRQELNGHGLIYVGQKWLKPSECLWNCTVAISGRLPLDHVYPRLKKFFVDKMKVRTMNINVLLQELGRTAKKTSPDIDEVKRIILTIGELLGSDREVQVNEEQLRALEKTAFLPVRGANGLKLFSVDQAFTINDHPRYGQLFENQAKILDFGHEEMTSLYPLFELLGLQNRFLSGLVESKTTVDKATAHQALEHYIRDRAYALSCCATYYNSSEYYNRKTTMHELLLAAEVFVCEEMWTELVLPEVYDSVTVQSDRAVVDIRFPDGKLTIYVPSDYDSLYSCFHTELPQALANALSIDNERAVKVVYRILNDNKKDLATIMKDEDLPEYPWFAKPVPSLQTGSFPALGDIEPNSSSMPTPASPADASSDHDRDHDVVVTRVDQRSTAPYARAESSIPSPVHVRSTGSHHTIWEEVARDQQYKRLLREVIRQARRGARSPQRRGGSLSLDGIDEALDELAHPPVDYAAFKLTFGDTGNGRFEENARVGAAGELYVFEFLKACGITNFGIDQWQSSIRHYVNVLPEYADEPSWQGREISDVMYEGNCPRLMELLRENTTFPYPAWLGVESGAPSMSTPVVNYHIEVKTTPGPCNTPFFMSSNQYRLMRDKACPNDSTTAPRDLYLIMRVFNLFSSRIGLQVYVNPWHLRETALEFVADPWKVVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJX9</accession>
    <name>A0A1C1CJX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="7">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">clpP</name>
        <name evidence="9" type="ORF">CLCR_05227</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJX9"/>
    <dbReference type="STRING" id="86049.A0A1C1CJX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05227"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03079"/>
    <dbReference type="eggNOG" id="KOG0840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT48833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="153" mass="16808" checksum="34F8F9DCD406335C" modified="2016-11-02" version="1">MYINSPGGSVTAGLSIYDCMQYIVPEVSTLVLGQAASMGSLLLAGGAPGKRYCLPHSSVMLHQPSGGHYGTAADIAIHAKEILRVRTQLNRIYERHLTPKNKDKKMTVEDIEKMMERDYFLSAEEALELGVVDEILASRKKKPEDGEKDKEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKD8</accession>
    <name>A0A1C1CKD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_04682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKD8"/>
    <dbReference type="STRING" id="86049.A0A1C1CKD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04682"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02958"/>
    <dbReference type="eggNOG" id="ENOG502SM93">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT48949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="613" mass="69591" checksum="493F82474208F9F6" modified="2016-11-02" version="1">MAKPRVKRHHHKVKTGCTTCRLRRVKCDEGKPSCRRCTTAGRICDGYDQQSKAAISLSWENHPWTHSWTPFVRPAASVEASPESYALPRLLLPPRLLVFDSAEEQQSYDFFRSRSVGELTEVFHIDETFWNLCVLQMSMTQPAVRYAVAALGAMHRIYATGDTTAIPADASDSQTRFALEQCNRSIKSLLERRGSEARAEKLSTLVACILYTCLASIQGHQRQSIMHLRNGMKLLDNLVQQKDVNNSGPWTSYHTQIQSFLTTLSSLEIQARSLMCEEDLPAWPTRTRIRGSSFPPTDIRFSSLSEARDFFESVLNDFQCFVLERDAENEWLLSPGASPRRSVMDDYELLVKKHFFGVEALESFIAKHDDDLDKRDQKTILMLRLHINIVEMYLRVYPLSLKHGELAWDHLEPFYLRIIRLGRQILGCTEEQLASLLCSPSEVEKNSTTTTTTTTTHDHSGKTHKYPKIPPAASILKKEQYTQRQHGPVFAFSQGVVGPLSTVAVMSRSPNVRREAIALLLLYPRREGLWDSHTAGRVAWVGMCLEEEMALKRRCHHNGEERGIKVASDIPAECRVRVVDMKYTGARTGEIHYNTGKQGEAGEKGKVVKILEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKM0</accession>
    <name>A0A1C1CKM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sensor histidine kinase/response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_04508</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKM0"/>
    <dbReference type="STRING" id="86049.A0A1C1CKM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04508"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02900"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000083">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative (AFU_orthologue AFUA_4G00660)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF11">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="597"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1154"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="718"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1056"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1070"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1107"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT49011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1279" mass="140466" checksum="6D23430294A5B09B" modified="2016-11-02" version="1">MAKEGAREREMHRYYQPWLETFMSTDFEPATLLPPPAGQADGHHPRSSRDKALTAFAQLGCLRLNVKRCVVTLLGTTKQYIIAEATKTLSLLDDAQHGEGDELWFGNSFIEREGGISADAMDPDPYTARDPDGSTFTAPALVVSDIAVHESYKTRGYAGRGVNFYCGVPITTNHGQVIGVYTATDDKPRGSISATELRFLVDMSAIVMQHLETVRNDRTRKRGERLIHGIGRFIEGDVGEESESPTPDASSNETKKNASLDRPKLSRNNKSPEFLGMVIKDANEPSEESKRTSSRPPNRQGEPLRQKSSDPGQGSDLGQQSKSSSNPQKAAERKEKVIRDSQHVFDRAANILRHCLGSDGVIFFNASSANLSSGSRMDNSGSVARVHHSKSKENRLSAKHDGSEAQDLEADKPTNDQSLSSDDSASTRGQSDSSSSQKKGRQKGEILGLAVLDSTKTVSIPEQALRRLVRRHPKGKCFTFDQFGKPASSDESSESMSANDAAKDAHDRTNANRHVFTTSTLLRALPGARTIIFLPLWDIAKQRWHSGLVVWSNDGGSLTNVEDNMICLKAFSNAIMNEVNRIDLALSDTAKSTFLANISHELRSPLHGILGSIEFLHDTAMDDFQSSMVISVETCGKTLLDTVNHVLDYAKIHNLSRAHRHAKGATQGSEYPGRPETSLTEDFDLAIVVEEAVEAVYAGQVFRTANADALEGKSPIQTAASRAMQQRQDRRDNISKGSAQRKSPVRLTLNIDDNVNWRVRSQPGAVRRIVMNILGNALKYTSKGCINVSLEVDRSRSKASSNLHLVLQVSDTGHGMSEDFIKNHAFTAFSQEDSLASGTGLGLSIVRQIVDSLGGKIDLSSEKDLGTDVRIWLSFPKSRNEAGADSDSHILPEMRERTTGLEICMLLPYDEKSTDNSMRSLIPMPTIESSLRNLIDQWFRMKVTTTKTMEGLSPDFFIYPEPPPIDYLMDFHGKPNSDFEIPVIILCTNAFEAASLRSNGVHYLTDIGRVIEVIAQPCGPQKLAKVLHRCMQRLRILKEEKGKKKFSQNVSLTFKKNQSKKDCSPTQDHTSSDQSRDSGDAEDHSHPAPGPTPDSPGRDAKRADLSGSPSENQSRSRRPSSANTGTTDEPVSVDAAAAAEGEAIPPTLESDRPRVLVVDDNQINLHLLVTFVRRSGHPHDSATNGLEAVQTYKKSVQEDGGKRAFKYILMDISMPVMDGMSATKEIRKFEKDQGIKTPAKVIALTGMGSDIAQNEARHAGFDQFLSKPVKFKDLVKLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKW9</accession>
    <name>A0A1C1CKW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carbamoyl phosphate synthase arginine-specific large chain, mitochondrial</fullName>
            <ecNumber evidence="5">6.3.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CLCR_04843</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKW9"/>
    <dbReference type="STRING" id="86049.A0A1C1CKW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04843"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02761"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="54"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="14">
        <location>
            <begin position="318"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT49168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="464" mass="50795" checksum="DCA95B3709E80E2D" modified="2016-11-02" version="1">MFRSELENASGVVVSVGGQLPQNIALRLQEEGKAHVLGTDPVDIDKAEDRHKFSQILDSIGVDQPAWKELTSVADAEAFADSVGYPVLVRPSYVLSGAAMSVIYTQDELKDKLESASAVSPDHPVVITKFIEGAQEIDVDAVASKGELILHAVSEHVESAGVHSGDATLVLPPANLDDKVMARVKQIAEKVAKAWSITGPFNMQIIKADRPGEEPALKVIECNLRASRSFPFVSKVLGTNFIDTATKALVGQNVPEPRDLMAQKRDYLATKVPQFSWTRLAGADPFLGVEMSSTGEIACFGKDLIEAYWASLQSTMNFRMPEPGEGILLGGSTELPELPKIVEYLQPLGYKFYAASNEVKDHLAKSGASIEVIEIPTTDKNKLRQVFQKYDIRGVFNIAKTRGKTLVDEDYVMRRNAVDFGVPLFMEPKTALLFAQCMNAKLPRAEGIPPEVRTWSEFAGDRMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLM7</accession>
    <name>A0A1C1CLM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11326"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="107" mass="11928" checksum="56FF29A0992A4236" modified="2016-11-02" version="1">MSAFSKFGESGLEFIARAKEDDPSAKKVFENKELGTPKSHVALTAVEEVPRLKLMLTAAGVSTCMLMALERRQFIDCILITLILVAYPPFVRKFRWLLLVALLSAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CME7</accession>
    <name>A0A1C1CME7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF1740-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_06610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CME7"/>
    <dbReference type="STRING" id="86049.A0A1C1CME7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06610"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09861"/>
    <dbReference type="eggNOG" id="KOG1972">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT49612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1013" mass="114513" checksum="170A70010CBD2CAA" modified="2016-11-02" version="1">MSRSQYDIPSAHQKHSHHAYRRSSSAITATNVPTARGEPRTNSQSSIFVEDRKGDMQILAYGSLHRNSVPRYRPAGRGRVLGLDPKYRITSRSETALWVEDAESDSTRKSRKETLLTKIADNDAATTIVHYKPSTWTNLERDFLALEHGQRPTRRRLGIDYLRIAAEAEESEESEPDVAEATVAEDPFEAYKKNPIHQRHLELSKATKEQPDAASPWLALIEFQKDLLYDDLGNWPSPRDLSERKISLYEQALSHVKAQDDRLALIVGLMREARAVWDVDKQASRWKAFLGDGASFDLWKLYVDFVQTNSVRFSVEDCLQTHLNWLKTFRVPRPGTTDRQRDSNCVYILLRLTLLLWQTGFTERAVGIWQALLEWNCFQPQHQHLQSNDFMSHFRDFWDREVARIGEEGSKGWDSDSAFESVPINDRSFQTENMDIQQWAAAETELEQTASLPARSLDEVGEDDSYRIVLFADIEELLFRPSSDSALGLLVDGFLLFAGLPPITLFDDGRAWKGDPFICNQYPSGSNLVDLVEQGDERIGIYMHYGEVSLAVKQRACRLPENLGPRSGRLLDSNPEFLRRVIAQLAGLPNDGEILAGIMEYAVAFDAGIDLKGARKQARSFLKDKGDRLRLYDAYALLEAQLGNFESAEKVWSTALSMRTSFDGDGRMHVFYMWRNWAYSHMCRGHFTKARTLLGMLADQVEDLARFRAENLNIQASSAAAQIKVEQHIKRQIDVTGLKGDSVSLRAMVDVLAYHRYLNSGLRLEVALDTYQDCLKPYTGVSQSKSALIEAIHEQQARFIYAHAVIFKKDFKPRVLNAILAQSVRTFSDNLILLILKSYFSRKAGAIDRLRQVDSVARLEQDTNSTGSVVPCIFDVLVELNRPAYSGSTDHSIRSAFKRATRVGSPGHDSVELWEAFVLWEASLVVRQAGSNRSSTGGIRPPSTEDLSTSASQAREALYASLHACPWSKNLCMLAFTDSTLRSALGDEALKRAYQNMVDRGMRLHIDISDVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMH9</accession>
    <name>A0A1C1CMH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMH9"/>
    <dbReference type="STRING" id="86049.A0A1C1CMH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07063"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09939"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="240"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="519" mass="57182" checksum="07C22696DEB2C688" modified="2016-11-02" version="1">MPSRGKASHGRDADFALDELLALVQDYHEFNPDTTVPVYPYPTSLHFSQQISRGRPCVYQLDRGVLENTLGDEQVPNGASHNHETDHAAKPHHAGVPVNDRKRAHLEEEQRSILGAPCFRWTKRTLRSLVQGEVEVAVTPDGRADSLYVLPKRRARQQDTSVMGTGVSSSTEGPRGGEHGPHTTLEDVAGPDNSDGDDALEHVFLQPATTRMTISKLIDELCPPIPSSLAADCTSTKPIYYLQSQDSNLSRPELAPLRAHLPATPPPFALPVLGEPDATNIWIGSAQSVTSTHRDPYENLYLVVKGRKKFVLYPPIEEICLHATMVRTGRWAFDEETKEFKIIMDTDTTTDTDTDGDAPNDGGANGEDGSISASKTDPSDDDSPSPSPSPLSSASSSVDANSAKIPWIPIDPFNPPPPSSTTYPYYRHARPLTVAVEEGQILYLPAGWFHHVTQECGQWEDRAEDGTGNGNLRLVPAPCIALNYWFDMDYSGEKHVMREMVGRLVEKVRRKEKKWEGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMM4</accession>
    <name>A0A1C1CMM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMM4"/>
    <dbReference type="STRING" id="86049.A0A1C1CMM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07105"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08691"/>
    <dbReference type="OrthoDB" id="2405944at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="46592" checksum="EAA7A5B36B446DD2" modified="2016-11-02" version="1">MAKPIFCATHPRACSTAFERVFMTREDLTSVHEPFGDAFYYGPERMSVRYENDEETRKASGYRDATYKIIFDTLEDEQAKGKRVFIKDILHYLVPPNQQAPKLAPSLYPHRRGIGTEATSNGANRSHGSDHANGINGVNGDHHVATNGVNGDYHGNGTNGVNGDHVNGTNGINGNHGTNGTNGVNGTGQKAPFPFPTEGEPGNPTIVPRALLEKFHFTFLIRDPHSSIPSYYRCTIPPLEEMTGFHEFYPDEAGYDELRRFFDYARETGLVRDRDAALKHESRNGEMQNGHADIPEVCLIDADDLLDDPEGILRAYCASVGLEFKPEMLNWDDEELQSRAKVVFEKWKGFHEDAINSTDLKPRKHKKAPKSEEQWDAEWKEKYGEQAAKVIRKTVDQNMADFLYLKQFALKPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMT9</accession>
    <name>A0A1C1CMT9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMT9"/>
    <dbReference type="STRING" id="86049.A0A1C1CMT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07679"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08726"/>
    <dbReference type="eggNOG" id="ENOG502T0DY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5376498at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="172" mass="18575" checksum="A3A4BD129313461B" modified="2016-11-02" version="1">MASHDELATLPTPDMITLLFKCHKSTVALSVLPTTPFAEIKPLLLGALQSRNIKTLPGSDTPLPEDPEDLEFGVLADKKDASKGWVPMVIREQEVTGPRGPKKKVGGKDSVLNQSPRGAGLSDGAWIAYRVKPEQKEPNGEDDDEADGTPNIDVEEDVGFDVVIPSFEDEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMV9</accession>
    <name>A0A1C1CMV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMV9"/>
    <dbReference type="STRING" id="86049.A0A1C1CMV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07638"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08745"/>
    <dbReference type="OrthoDB" id="4115400at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="175" mass="20106" checksum="0D1FB437A5BDCCE7" modified="2016-11-02" version="1">MSVSPVLSNADLASNNDRKPSMDWEPIENGTDHELASPTAPKTQAAQSTEATSSPAEPPWRHLPPYQKYCYPWTEEELLEAVREDHSWLNPDPAKAEWCKRNLMESTHPAVTFALLKQWTVERLEAARPKSRQVTVQLGPPRNEDKEEYVVVERKKKTIRPKQSSHCDEDDYVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN36</accession>
    <name>A0A1C1CN36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN36"/>
    <dbReference type="STRING" id="86049.A0A1C1CN36"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06558"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08810"/>
    <dbReference type="eggNOG" id="ENOG502SF1H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3365616at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055781">
        <property type="entry name" value="DUF7357"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056398">
        <property type="entry name" value="Tudor_Coilin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24054">
        <property type="entry name" value="DUF7357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23086">
        <property type="entry name" value="Tudor_Coilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7357" evidence="3">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Coilin tudor" evidence="2">
        <location>
            <begin position="785"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1042"/>
        </location>
    </feature>
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        <location>
            <begin position="1044"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1135"/>
        </location>
    </feature>
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        <location>
            <begin position="1159"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1240"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1387"/>
            <end position="1396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1396" mass="153985" checksum="923CD99F1D7B5B3F" modified="2016-11-02" version="1">MRLRLLIQRHALPPVPIIFTTGIGPASRTKSRSATVADLLLDVNEIVPLESADGEWGLEDYAVEIAAKAGQELAYECLHFQTIESVLRENDEVIVRALSNEDIRVRRLGKRHQITADGRHLIDGVPFGKQWLREIQRPDILIPSRKRRRLLVGEDSTLDAEVDLRRILPAGREDEDHPGALVRFMDNDEDEDEEDDDDYVDSEEAGAQEPRRRITLREEFDDADVDSEDEPELDGEAEAADLSSEVAQLLEDAAEVERASHLAIANQVLENQLKRKRPIEDDGEHEHELEKETFDGFSTGGARSSRMVNGTADVDTNGVSDEESDQDDGSDSILDEIAAEQEGRRMKNIREDEQDDSDDSDVTSATDTSSSDSDVDSLMDEIAMQQAKRRALNLITSSETGVDEDETSSSSSDTDGDDEVSDTPSNSGSDSDSDDTSESGSVSSSESQSESEEESLETNRKEVKVPELPATTATSGGIPFEGTRRTHMNNNRAKRRNRLKALKQQGLLPPHADFKALAEYDSKLAREELEGQQQEQQRAIVTNEKDVVVNEDASLVNRDDEMSTDEAVAEHNKENVNPRISDGAAPRDDTPAERVSAVPELPETSQIDSPSIMEQNPKRSRLDVASSRRLILGSLGVRAPRTAEERQKAVEKLSQDIRQPRHPEEEDIRTVSQTLQSTTSAEHDDSWMEKLIISAVECEEPGGVLPPPPFPFQQGWARSNKNKRKMRDQSQFYQGRNGHRQQEDERVAAPDVATLNYDDDPVEKEGTEASAMVNRDADELPTEKELDSLPALEQEQVLPGATIAYQELHVDASTNYQPAVSPYRIGRVSHVDGDGVVHLQLEKGSFGSQNPQIDKVTGERVYGKFELVEEDAEEDDGIRDISYSSMIRPKLLKPSSKASLVQVQDSSNMVGLRGGEAAIPSLDDDEVVVPESAEQEQEIETQIRLEMQASIETGANEQPVMAAETIDTPRKREINGIIKDAGFESALDEQLLQPIMNPAADDSENAQGQDDTGGQAQGKYAHRFRTRSPRVIITSSDQQPSSAVDDELNFEDDPTDAGVSSIPATSSPYTPTQTTVEYPHISQMDIDSSAPVRTTNSSSHQDAQKLSPAVEVDLSFTDAGREKAREEQVADRDDGLDGDEDVSEVTRRKYSSLPLESENPISAQTDSSGPGEHEIEQSPLPQVVSDLISSQTMNPDNEGSSVPQDSFLDGLGYDGNDSSYHDSGLNEDSDLPSLSDFRSSRRSSRRTSTRSTKKNSVSPLPPRPARKSLRSSNASGRKIRDPTPPSGLELPPSSQPEFKQSQSQREPRLSQIPTNSQVVVDLTFSSDPLSPIESSVKDQDDGESDFTLRRRKNRKSDDSGASRKTGLRGAKQVPQDSGIGKRTLLTRKRDSDPKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNK8</accession>
    <name>A0A1C1CNK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ubiquitin-like protein DskB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNK8"/>
    <dbReference type="STRING" id="86049.A0A1C1CNK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07167"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09008"/>
    <dbReference type="eggNOG" id="KOG0010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14324">
        <property type="entry name" value="UBA_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000024">
        <property type="entry name" value="Ubiquitin domain-containing protein DSK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="12"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="402"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="449" mass="47630" checksum="6B01BA9C786EF985" modified="2016-11-02" version="1">MADTAGAEDASVTFSVKSSGGQKYTLTVPLSMTTIDLKNKLASEEYANVPASAQRLIYSGKVLKDHETLASHNVKDGNTMHLVKSAASNQRQNPAVQSSAPSTPASATTSQGVAGVPQNLASGTGNDPLAGLTGARYAGFAQLPSAAALQENLSPDDFLRQLDNPHFQQMMREAMGNPQVQDMIINQNPHLRALGPQARQMLNSDYFRNMMTNPQMLRNMMQMQQQMGMGPFGGAGGQEAFPAPGVTNTTEGTTGNTQNTSNNQPGQPRQQQPQPDPFALLQTLGNPFGNFTGGQTGEATSQAQAGGQQQNQQPFNPFMALFPQAGGQAGAQAGGNTGTTSPPPSYNPFNPQNNPLLQNPEAMQQMLQAMTGGQQGGTGNDMGGLFDLFGGGQPAAPADNRPPEERFSQQLQQLNEMGFYDFDRNVQALRRTGGNVNGAIEYLLSHPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNR6</accession>
    <name>A0A1C1CNR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Double-strand break repair protein MRE11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNR6"/>
    <dbReference type="STRING" id="86049.A0A1C1CNR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06556"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09030"/>
    <dbReference type="eggNOG" id="KOG0269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="274"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="690"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="755"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="851"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="991"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1289"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="873"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1002"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1289"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1354"/>
            <end position="1370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1386" mass="152930" checksum="7FF58890C0B0DE59" modified="2016-11-02" version="1">MSDPSTSQSQNLAPPPAPPLPPGRLGQLQRIIAPWGKHIGSKAHGSSAQGERDGGLGRIGGIHTYSPHSSRTVTHRTGIPIAALDINKSKTHAILAGKEILKTVRIHDGKITEDFNLRASISSYASAHISPHSDSAEKRREYLPARDVKWSIGNWEHIIATAATNGRIALYDLNAPSAKTEWAWLHEHTGQINKLDIDPHAGYLLLSASQDKSVRLWDLRAPKPDKSRTRFEVRSAVRDVRWSPVEPFDFAVCADGGFVQKWDARAPMLPKLSINAHEKACYSLDYHPDGRHVISGGFDKYIRVWDFESDKKRQKPVRQLKAPHAIKNIRWRPACSILESEETNLWQSTQVAVSYHHDDPRVHIWDLRRPLLPFRELDKYTSPANDLLWADKDLLWTVGDDGIFTQWDVRHNTPFYNQLAPCTAQFVPDGRYYSFSEDREVRHAASHGDSAVGFLSVPRDKLSSGDDGLASRSLTDDEGGLESTLGTSSRRRETTTVPSRSNKSQTNSPQSMDQKPPILSLDEAVLTRPDLFNNDQVGAGGYVPGVAVEAEVVEYLASHYATPATVELNRSCPDTILHRLQEAFDQNAAACDVVGMHRTAQTWRILGAVVVPELRDWADANRARRRADAARRKETLESFRSGARRPALSPLAGLPDRGHNSHYDSKGYKLISSLFRGVAEGDRVRAGLDVDSTSNMTTPLAKPLPNSPLTDDKKWAQANIDDRLDNLPPLPPSVLSSHSTAAAAARALMDSSDQAIKSDISSPKQHKSTETSKKPATVTGPPVSPVKRPKSNSLVEQKHAAGPRRSQEDRRAALRDYRAQARPILSLGDPVHHGAPASIHDSAESFPMFSVSTDSSHKVPSVGRSLESARNAGRTSMQRQPSDLSSANDDDFDGTYSYRSLDRAIEDERVNDTFDEPSPSVSAIEPSLQMRFGLDGQTPSSEGQGTWRAPREVKDSWDASREHEPILPSQLGTAVSSSPDIFHFEAGTSVPKPRIHTSNPLRSDHLRHSNSENIRPNESELSKTLSLDELDCPTYLAQDFRPIDLSRYEPKRPFAWSSIPLICQCICFDLESGIAYAQFSAHLLMHVHQYFFHPSFCSMEATPGKAVDNLADRLMTPQFGHRIIGSIFEGHLSFLTQMGLFESAALLRKVCVELEYLQSYQSSTDGKPAASGLPDRDHSTLSVVCGSCQAPMPAGRNTCERCRQARAVCPICESLEDGYKRGPDTNPAGHTALWGQKNSMWMSCHACGHSGHVRCLREWFSQHFSQGRCPAPGCGCDCGPGLTREHRIERQIKREDEVKLIRGTSPGHNASGSTKRDPLKATPSPAVDKARAALRNSFAAERTTQSGDERNLPGRRGSNRGRTSGFSSSRKSVRLVTPGEEEDGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPG5</accession>
    <name>A0A1C1CPG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPG5"/>
    <dbReference type="STRING" id="86049.A0A1C1CPG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06768"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05613"/>
    <dbReference type="eggNOG" id="ENOG502QPR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="15"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="570" mass="65219" checksum="1EC83123025E77F3" modified="2016-11-02" version="1">MAVPEPSQNRQKNIFVLCFDGTGNKFSGKETDSNILKLYRMLDRTDVNMYTFYQPGIGTYITTHSIQTTSTLGRIRSWYLKTKDEAVGTSFADHVMGGYKFLMRYYSCEDDLYFFGFSRGAYTARFLAEMLDHIGLLAAGNEELIRFAWKTYAKWAARSNDGSKEAHKAEKEQYEFMRGFRETFSRPVRRIRFLGLFDTVNSVPRFESAWMQRSKFPYTARSSAKVIRHAVSIDERRAKFRQDLIGGSPQQDADHIEPEMHRYESDLAQMNEKVENQKSHEQNSTQQGPRIAFSNSIGGHLSVPDQVAPKSSSDSLAGPMHSASTEHLRERPKSPRRHARRTWSGARRPQDIQEVWFAGGHGDIGGGWDKSDREHWMLSHTPLVWMLHEAERAGLKFDPGKMARLGCSPHAVDEFGERIEDTTTRQAFIERLESSFTDSVAHDCLQFGSGLPRGTVSFWKMMEYLPFRRMDLQDGKWKAIRWPLPMGETRDIPDDAQIHISVIRRMQANPHYRPGNLIVGGGGRGVRKAPEKYGIGEWLPHRDEGDIIRHTVVRKKRSKSDSPNAMPNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPJ4</accession>
    <name>A0A1C1CPJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPJ4"/>
    <dbReference type="STRING" id="86049.A0A1C1CPJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06991"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05581"/>
    <dbReference type="eggNOG" id="ENOG502SDF2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5424234at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="54332" checksum="CC229CD842CB1850" modified="2016-11-02" version="1">MTAVLPQGLINANLDVQQYALDDSNAAFTNSDALRKFWRVYAIQSNATQDDAAVRSRNLFWRIWSSRTLTQSITPPLLTQLWQRCSQEFDLTPIGGIPALPEPPALQDPFAPRQSRNRLASPSPSSEVHLIHDSTPRGGQNTVMTLQGFRWSAADQPTQDDAPRLSFRPAGEARGQRLDGSSGSTSQTTSESSSRPTLSRTASGGRQRLPVLASGGKARARPLIPRRKSSTQKSGGGSNQPKSARGPTENSTAEAPDTSARLERLSAGGPPPGLPLPLLAAASGPAFALPSASSWQSVESTSPNPPLASTAPIQSNTSGDLVHPDFRGKFVENQKKLASFTNLPGLARMRRPGSIVRFADELPQVEPDKSKDREQPTSPLREENLGRSRLRTSMASAAISDDGDSDSSSSPMELPRTKSQLSLLINSKRSETGSSDIGPPAQAHESKGKDNEARQKARSKEQELLSMGRRDGVTKAGGVQVPRQQRVSELEDPAYQSQSSPEPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPP8</accession>
    <name>A0A1C1CPP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">mts2</name>
        <name evidence="13" type="ORF">CLCR_07280</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPP8"/>
    <dbReference type="STRING" id="86049.A0A1C1CPP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07280"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05560"/>
    <dbReference type="eggNOG" id="KOG0726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="171"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT50443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="393" mass="43430" checksum="844DAFD19928B4F2" modified="2016-11-02" version="1">MQRVHDHLLLEEEYVENQERLRKTKAAQTQAPAAATEGAEPLDRNSDERSKVDDMRGSPMGVGNLEELIDDDHAIVSSATGPEYYVSIMSFVDKDLLEPGASILLHHKSVSVVGVLTDDADPLVSVMKLDKAPTESYADIGGLEQQIQEVREAVELPLLHPELYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGDGPRLVRQLFQVAAENAPAIVFIDEIDAIGTKRYESTSGGEREIQRTMLELLNQLDGFDDRGDVKVIMATNKIETLDPALIRPGRIDRKILFENPDTATKKKIFTLHTSKMSLAEDVDLDEFISQKDDLSGADIKAICSEAGLRALRERRMRVNMADFRSARDSVMKTKNEGEPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPR0</accession>
    <name>A0A1C1CPR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06878"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05528"/>
    <dbReference type="OrthoDB" id="4127946at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="557" mass="62427" checksum="19FB504E412C69D4" modified="2016-11-02" version="1">MSQQIHFVETKPGTALDSSQVRALRSHVRKVNLERSTQKSTRRLENFRSLTITDFSESGKAKGAKKKQSIQLNVTHLETEIRDLPWGEDPLQKCRLAPDSPEIPTRAFQCLSTSCNLFLPKRCSRSRSSSQGPQSQSPSQHSSPVDSPQSDETHPHAARIANATDVDEARINQLLRGCAFRIATEPLLSSDFTHGDLPVVPLFLECPSHSAFLYAFLYSILHIHNSCIATNESLALKTKAIECLRGDLRKDDPNIRALTIGTILLLSCVAGPSIIAETLLNPQHIPKACTSSWSTAIRTASAYELRYFVQSSDFQVLLNRPQDFPTIIALPPVPLGFELHEEVISPDVLLSVRIILYLQDHTSPSTSNPIMIEDLQARVEARLVFDEKASREFGPIAECCRVAVYIVSYISSSSTWKGAFVPLRLAEKLLASLEKTNEQDLWRYRRDLFLWLLLVGSSVGRGQNCFAAELATRYQQFIQNVKRDVRSWTDLKNGPGAIHSVMETFIYADDWVAKRYLLPSWSDLEPTVFSCGSKQGDTDMDTEALLQELVQNTNHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPX6</accession>
    <name>A0A1C1CPX6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein transport protein SEC61 subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_07034</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPX6"/>
    <dbReference type="STRING" id="86049.A0A1C1CPX6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07034"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05487"/>
    <dbReference type="eggNOG" id="KOG1373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005048">
        <property type="term" value="F:signal sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070843">
        <property type="term" value="P:misfolded protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="12">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT50521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="487" mass="53243" checksum="1CF1768D511323A8" modified="2016-11-02" version="1">MSGLRFLDLIKPFTPLLPEVAAPESKIPFNQKLMWTGQESRTNEGNAQCTLLIFLVMSQMPLYGIVSSDTSDPIYWLRMMLASNRGTLMELGTTPIISSGMVFQLLAGTHLIDVNLDLKSDRELYQTAQKLFAIILSFGQACVFVLTGLYGQPSDLGAGICLLLIVQLVLAGLVVILLDELLQKGYGLGSGISLFIATNICESIVWKAFSPTTIDTGRGKEFEGAVIALFHLLVTWPDKTRALREAFYRQHLPNVMNLLATLTVFAAVIYLQGFRVEIPVKSSRQRGMRGSYPIRLFYTSNMPIMLQSALASNIFMISQMLYTRFSDNLLVKLIGTWEPKEGSSQLYASSGIAYYMSPPLNFTDALLDPIHTVIYVTFIIVTCAVFSKTWIEVSGSAPRDVAKTLKEQGLVMAGHREQSMYKELKRVIPTAAAFGGACIGALSVASDMLGALGSGTGILLAVTIIYGYFEIAAKEGDFGQGLKGLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ65</accession>
    <name>A0A1C1CQ65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL17m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mrpl8</name>
        <name evidence="10" type="ORF">CLCR_07580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ65"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ65"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07580"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05402"/>
    <dbReference type="eggNOG" id="KOG3280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1030.10:FF:000005">
        <property type="entry name" value="Probable 50S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047859">
        <property type="entry name" value="Ribosomal_bL17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="195"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT50613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="231" mass="26773" checksum="E165A0CEF6244813" modified="2016-11-02" version="1">MSTLKYRHLGRDSAHRRALLRNLVTSLIANESISTTWPKAKEAQRLAEKLITLGKKNTGAARERAKTIFFEPEREGHMDKLFGELRERYADRPGGYTRVLRQEAIRDDAGPSAILSLVDGPRDMRFSMTAKAIVRQRKENLDLNEMMLANMRKVTRFRINGEQALDEEVQRLERDLKEREEKEMIDFEEDGTMYEWARGEKSRPSGIKSKEKKGPGRLRRQRVGEDKEVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQP6</accession>
    <name>A0A1C1CQP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate-semialdehyde dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="9">1.2.1.16</ecNumber>
            <ecNumber evidence="3">1.2.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NAD(+)-dependent succinic semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_06928</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="9"/>
    <dbReference type="EC" id="1.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQP6"/>
    <dbReference type="STRING" id="86049.A0A1C1CQP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06928"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05224"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="29"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="319"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT50808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="535" mass="58544" checksum="CB5BAD46DEE12F7B" modified="2016-11-02" version="1">MADILLKKIPYTFKDPSLLDTRSFIGGKWVDAGNGDKFAVLDPSDNEQICHVADLGRDETRQAIEAAQSAFTTYRKTTARDRRWLMRRWADLIKAAKDDLAAICTLELGKPYTESLVTVKYGTDFLDWFEGAIERQHGETIPAAKGENRIFTIRQPQGVVAAITPWNSPVAMVTRKVGAAIAAGNTVVCKPAPETPLCAIAVAKLFERAGGPPGVLNIVTSSTEKSKLVGEEMTQNPLVKHLSFTGSTAVGRYLHAECAKTFKKTSMELGGNAPFIIFEDAKLDKAAEGEYCPYVHGEARRHQKVMNTIPSTTRSTFYAIRCLISSKFRSSGQTCVCANRIFVHRSVMDAFATVLATKLSSTFRYGSVWDKNVNFGPLYSARAFEKIHAQLDDALAHGAKLHADETGQTQQAGHDLGPNFYAPRIITHATKDMRFMREETFGPLAFLVPFDTDDEAIALANGTSAGLASYFFTENISRVWRISEELESGMVGVRVGLISACEQPFGGIKDSGVGREGGKDALNEYTEIKSITVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQR9</accession>
    <name>A0A1C1CQR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative RING finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_08498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQR9"/>
    <dbReference type="STRING" id="86049.A0A1C1CQR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08498"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09492"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF416">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE GODZILLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="335"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT50846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="491" mass="52655" checksum="4EB4C2B85CC6EE09" modified="2016-11-02" version="1">MLSLFGSRAAAQTIAPSNSTQDLFPSSTSPRFIMNGTEFSNIPVVRLAPLGRYAEMSHDNFLRVEVEGHLVNVDASNANDIAGTGQFSYISCDPEDYPGNLDASQVFRIVVNSPRANIVILYSETSDHCIVTGLDTLPNIGGILTTTDTMLASSLAALSLTEESPGTATILPDLNSYTNSSSPGWGGNGGLGNSPTTAVAMIILYSITGIITALFVVIIVTGAVRAHRHPERYGPRNIVGRGRQSRARGIARAMLETLPIVKFGDHQDLPPKPAEGSDIEMNAGSTHPPSTDNTESANKAVAGEVVTSETQSDRAQAMIATANPDGTDAEGHLGCSICTEDFKKGEEVRVLPCNHKFHPDCVDPWLLNVSGTCPLCRIDLRPLGQEIEGEERRGSTATTDHDGQLPPPLPAGAADSGGTPYRGGRRETIANLRHLAHGSRAERIAALRQMRIERLGSNSDQPANDEERSGLARRFRERFRIRTERRGATAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQS9</accession>
    <name>A0A1C1CQS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5">5.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phosphohexomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Phosphomannose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MAN1</name>
        <name evidence="16" type="ORF">CLCR_08662</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQS9"/>
    <dbReference type="STRING" id="86049.A0A1C1CQS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08662"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09501"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF4">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="15">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="AraC-type arabinose-binding/dimerisation" evidence="14">
        <location>
            <begin position="360"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT50856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="407" mass="45059" checksum="6EA8D8B3DA43730F" modified="2016-11-02" version="1">MAESVIPLKCTCNNYPWGKKGKESLAARLCSRTNPDFQIDDSKEYSEMWFGTYPELPSYSLKTGQDLQQILNEHKDALIGKKVCDKFGADLPFLPKILSIAKALPLQIHPDKGLSEKLHKEDPDKFSDPNHKPEIAVALSKFEAFVGFKPHAEVQELMQLEALTRFLPTRADGVDVSDDELLRQITTNMLKADEKTVESTMKELQATSKGELGRHAYILDLAPRLQDQYGVTDNGNLVALVCMNYLVLDAGAAIYIPADGIHAYLSGDIVECMARSNNVINTGFCPRADRDSVDLFARSLTFKQHDPNEPILDRRRSEKSGNGKTIEFNPPMSEFNMLVTELSGGEREKNKPIDGPSTLIVTSGSGKLNAGGQEYDLQEGSIFFVGQGVEVEYSAGDKLAVYRAYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-01-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQX4</accession>
    <name>A0A1C1CQX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQX4"/>
    <dbReference type="STRING" id="86049.A0A1C1CQX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09265"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="129" mass="15126" checksum="7E563B5BD6936893" modified="2016-11-02" version="1">MGMSTVHSQPYKNVWVPTHYVKVRINVKVRINVKVRINVKVRINVKVRINVKVRINVKVRINVKVRINVKVRINVKVRINVKVRINVKVRINVKVRINVKVRNQIQGLDQRSPEKLCCINSHRSVCPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQZ8</accession>
    <name>A0A1C1CQZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_09355</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQZ8"/>
    <dbReference type="STRING" id="86049.A0A1C1CQZ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09355"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09577"/>
    <dbReference type="OrthoDB" id="14603at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT50934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="82" mass="9526" checksum="B6F91D54BB3A33B8" modified="2016-11-02" version="1">MLTTANFAVAGFVLSASGMYYWCDHRRREEARGMALAVQGMKMLHEKKAREKLAAEEAARAATAAKAEEEERRRKQQWYKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR93</accession>
    <name>A0A1C1CR93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SAM50-like protein SP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR93"/>
    <dbReference type="STRING" id="86049.A0A1C1CR93"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08418"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09657"/>
    <dbReference type="eggNOG" id="KOG2602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.50:FF:000008">
        <property type="entry name" value="Mitochondrial outer membrane beta-barrel protein Tob55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="6">
        <location>
            <begin position="170"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="513" mass="55710" checksum="514678E571EE2724" modified="2016-11-02" version="1">MAETGGENNIFELLKRADPAELEKRQAAISRRLESTFQLSQQRLADLIDQNSTLPSTVSSVTILGSPNTRHGFLQRVVDPLLSSNRDRPYTQSELIREVAKTAEKLRKFGIYHEPVSVYLDKPSQTDPTTTPTDVAVYYSVKEKSRIFAKTGTDLGNAEGSAYANVQWRNLLGGAETLDVNASIGTRTRSSYQASFDTPVLSNPDLRFQLGGLQSATQKGFASHEEVLRGGWSKFRWLSSAGSFHELGYNGVWRQITGLAQNASQTVKSEAGDSFKSSISHAWTKERRDSPMLPTRGYYAKTATELAGWGPLQGDVAFLKTEVESQSATTIPIPGIKGDSGVTFTTGLRAGLLYPLTLGSKQTPEMSRINDRFQLGGPTDVRGFRLSGLGPHDGPDAVGGDLYAAGSANLLVPLPKVGKDRPFRLQAFVNGGRLLAINNPEREGGMTSQEIRQSVSDAISEMGNGLPTMSAGIGLVYAHPVARFELNFSLPLVVRKHEEARKGVSFGIGINFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRJ4</accession>
    <name>A0A1C1CRJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative kinase mug58</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_08889</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GLYK kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRJ4"/>
    <dbReference type="STRING" id="86049.A0A1C1CRJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08889"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09741"/>
    <dbReference type="eggNOG" id="KOG2878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001691">
        <property type="entry name" value="Probable ATP-dependent kinase TDA10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT51112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="314" mass="35078" checksum="50DCFC993DD17EA1" modified="2016-11-02" version="1">MPEIVDDKAQHVVPFILSLLAEHQKVHAASSNAPPFFIGLNGVQGAGKTVLVDILQKTLTSPPHNLPTVVFSLDDLYLTHEDQVSLAQAHPDNPLLQHRGQPSTHDIPLAKAVFDGLKHNKRTKIPQYNKAAFSGQGDRVPETEWAEVNTDASHPVRVVLFEGWCVGFRPLSPDALRQKHAAAVEALKAATAETPYRGRLGHNTLSSVTTINEALRQYDELTAQLDAFVHIDALDPLYVYKWRLEQEAGLRASRGSGMTDDQVRHFVDGYYPAYELYTDTLRDGVFRGVKEDWRGRQLRLVVGEDRKVREVVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRN6</accession>
    <name>A0A1C1CRN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tyrosine decarboxylase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ELI5</name>
        <name evidence="8" type="ORF">CLCR_08365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRN6"/>
    <dbReference type="STRING" id="86049.A0A1C1CRN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08365"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06919"/>
    <dbReference type="eggNOG" id="KOG0628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="535" mass="59037" checksum="11A2113DF70DD9CB" modified="2016-11-02" version="1">MDADQFRKAAHAVIEEIISYNQNLPDYPVLPSIKPGFLAPQLPTSAPEKPQPWAEIQPDIASKIIPGITHWQSPNFMAFFPAGVTYPSMLGEMYSAAFTAPAFNWLCSPACTELETVVMDWLAQAFDLPKDFLSTGPSGGGGTIQGSASEAIVTCMVAARERYLHSKCDAEGLKPGSQEREDRIDQLRSRLVALATDQTHSSTQKGALIAGTKYRSIPTKLENELSLQAEDLEAALEQCKAEGLEPYYITLTLGTTSTCAVDDFAGLAPILKAHPNIWVHVDAAYAGAALVCPEYSSKYSPLMAMADSFNMNMHKWLLVNFDASCLFVQNRNHLTRTLSISAAYYTNKHSDSGIVTDYRDWQIPLGRRFRALKIWFVVRSYGLEGMRAHIRNSITRGEIFADLVRERSDLFELVTQPRFALTCFRVKPSALPAQTSTAKTDTDFVPQQAAMQQQEQDANDVTKRIGDLINERGEIFITCSSSAGKSFMRVVSGNPLGEEKYIRSAFDIIVRTTEEVLASSSNGQDKAKLSNGYAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS27</accession>
    <name>A0A1C1CS27_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carbonic anhydrase</fullName>
            <ecNumber evidence="2">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_08878</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS27"/>
    <dbReference type="STRING" id="86049.A0A1C1CS27"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08878"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06776"/>
    <dbReference type="eggNOG" id="KOG0382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03124">
        <property type="entry name" value="alpha_CA_prokaryotic_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041891">
        <property type="entry name" value="Alpha_CA_prokaryot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651006" description="carbonic anhydrase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="8">
        <location>
            <begin position="36"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT51309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="299" mass="32354" checksum="881B807F0FF1FA24" modified="2016-11-02" version="1">MFASLFLTSLIAVAKVAANCAHGTSAFPRLPNVTVSTFGYDALKGPLNWYGLNKTANVACEKGTTQSPIVIDASISTVPGSTLKWTVPDYPDGAEFENLGTNVEVIVNGSLVDSDSGVSYSLAQFHFHTPAEHRLEDEFYPMEMHWVFESEGTLGDLLRLNEPGADMSRTAKQFAVVAFLVELCESPGCTDPVLDAVFSAVEDIAVPGEAVMTGPLAFGELVDKLEHSQVYRYGGSLTTPPCTENVDWLISAELLYIDVPTWLAVKKVIKYNARYTQDTLGAVNLLQNVADELCNSTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS34</accession>
    <name>A0A1C1CS34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_08443</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS34"/>
    <dbReference type="STRING" id="86049.A0A1C1CS34"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08443"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06773"/>
    <dbReference type="eggNOG" id="KOG2267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.80:FF:000003">
        <property type="entry name" value="DNA primase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140914">
        <property type="entry name" value="PriB N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="298"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT51312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="502" mass="58355" checksum="B8F02A4960923258" modified="2016-11-02" version="1">MTAETRFDPKRKLIHHKKTQFATASYKENEYPNRLSLYDVPPTQEISLEEFETWAIDRLRILAEIEACSFRNKSPEETSAHLEPLLKKYLPLSSNTAAAGGVVDQKLKNQRRKDHYSHYILRLAFSGTEDLRRRFARVETMLFRLRFQQDDTRERQAFIESLNMNWERVQEEEKRELAEQLLAATPGLRRIDGENWFKVDWTCVPELVEHRTVLVRKGKAYVPMREQTSMVLTEFTARLDKALELTARALPRLDEDDRLTPILNHLSKNFATPDAGFSDSDSSVPGAPVTAANVDNLSQHFPLCMKHLHNSLRKNNHLKHFGRLQYTLFLKGIGLTLEDCLLFWRQSFKLLTDDQFNKEYRYNIRHAYGDVGGDANRRGRGYAPYSCQKILTEHPPGTGEAHGCPYRHFSVDNLTSMLQATGVHDRDVLRGVKEDVEKKRFHIACNRVFDWAHKQEIRKVKDEGIWGPAELETIVHPNTYFKRSYLLKNLGNMPKQDVKMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS36</accession>
    <name>A0A1C1CS36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pisatin demethylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_08494</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS36"/>
    <dbReference type="STRING" id="86049.A0A1C1CS36"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08494"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06802"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="55440" checksum="2EFE834FAABA80F4" modified="2016-11-02" version="1">MFFSPSFWLWSLAIGVLATVYLRYRRLSSVPGPFLAALTDLWRFSLTRSGHFSDTLKDLHTRYGAFVRIGPNAVSISDPAAVPTVHSMHGEFRKADSYSTLRALFNGKIIGSVVDLQDENEVSALKRAVGSAFATKHLLDYEPDVDHTLDRLVQAMRKRRTFSLLDAMQQFQVDFLMKAAFSRVTDYLETNRSTDAISGDARLKHWYIWQSLPGLEWLLFKSPLSPAWYRKPIKPPAWTAMASEEYQERVKSHSDKPVSMASEKPDLLSKYLSGWEQHKETVSETNIVRMISSTIAAGFDTSACTITMILYNLLKHPAAVKKLRSELDDALNSGRLSSPPRFNEVDKLDYLGAVFKETMRLQPFLKALLEREVPPGGADIAGRFLPGGTTVAISVRSVHRDIAVFGKYADEFRPERWLEADQQHRPLMERSMLAFGGGKRVCMGRHIAELEMKKAVPRLLMEFDVSLTCSTNGVTANRASQTDLVERPKLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSP6</accession>
    <name>A0A1C1CSP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSP6"/>
    <dbReference type="STRING" id="86049.A0A1C1CSP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09086"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06559"/>
    <dbReference type="OrthoDB" id="3344043at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="225" mass="24208" checksum="4C8C75A9153BF6C9" modified="2016-11-02" version="1">MAPPEPLASPTKIPLLQEKALDTPATEFSGESPPPTPGQQHASKNNMEGALTSLLWGAFGPCVPVAVVCSVLLTAVLYNRIPESYVFDPAKQTKMSDDALSALHGIQEIENNGGSKAYYLYEKGITNPAVLHMISSWTAKILPFVTGASMALVAFLAGQRIIKATSTKSEKLPSPHQVSILINLLNGGGAQPLLDTLKYRWQNHEDLVQPVPLAFCCLLFIVVMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTA8</accession>
    <name>A0A1C1CTA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_08517</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTA8"/>
    <dbReference type="STRING" id="86049.A0A1C1CTA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08517"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06369"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="12"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="434" mass="47979" checksum="E4C5EE6C02C9E3DF" modified="2016-11-02" version="1">MSPHAVDNQVLDVIVVGAGIAGLAAALAIHDAGHRVIVVEGASVLREIGAGVLISSNATRELIRWGLEDDLRDVIVQSRVSRVLRWDNGEVLSEVKMDPSFALKKYNAPVWMLHRADLHTAMLKKVQSLGIEIRLGSRVVDADVATASVTLASGEVLYSDFIVGADGVRSKMRDIISQRPVPALPTGDYAFQFALEIEKYKDDPVIAPLVEGHAATAWWGPGRHVIGTLLRGEKLFNCVAVFPDDGSLGDEHKQMGADVDELRRNFSDWCPAVRTILFHADPSSIVKWKLQDLDPLESWHRGHAVLVGDACHPMLPYLAQGASQAIEDGAVLAQCLANLPLDRVGPAFQELRFARATQIQQNARKQKTENHYPDGPEQRARDERLKDPTQVRAWQWEPVAGKPTKNWSDGLFGYDSKAECEEYFREHDAGRDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTD2</accession>
    <name>A0A1C1CTD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTD2"/>
    <dbReference type="STRING" id="86049.A0A1C1CTD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08685"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06345"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="283"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="400" mass="44112" checksum="1F1DE7B3EC666573" modified="2016-11-02" version="1">MTYYQDPFLLDQVRRTDPEPTSKLANPEQQYHDEAYFAGFPANGDDQQTSAPTKCINPWGVPSQVSIRRQHSKPEAYPMRSARSDDSYISPYLDELESPFGDTVDTVGPLELQRQQSDGSQFPALNLDLDLDLAMDMDLNRQEYNTPRDDQWPLFGSTNPNLEAVGLSASPGSGSAEADTPITPITPTSTSTSPSAPMSAPASTTTFVCGYPRPRPRCQTRPQPQPQPPRTRTTTRRTSSSTPHQRKPNPTTTTRSSGARTKKRNPAPSSPSSEDDSASAIQKAKHAHSIIERRYRDNLNGKMMQLHRVLLAAETAESSPMNDANPDDAAAVAGAFPQSVSLDETKAQAQTVGRVRKSDIMTRAINYIHRSEAQMRHMSGEVARLQDQIRVYQKLVEGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTH8</accession>
    <name>A0A1C1CTH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_08856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08856"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06314"/>
    <dbReference type="eggNOG" id="ENOG502R9NB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4108861at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="328" mass="36274" checksum="82E2F85DAA0BDD2D" modified="2016-11-02" version="1">MLILDLPNEVLAQIVRYANFNGDLSGLRLTHPRLLGALVYQDRLLLEDTLLRYGISPRALSLYRSQHVRRPFPHSDLDPAMLDVLTLDRFLRETGSLAVDADQAPRSLHNVLVEHRPSSREPLMLFAAFTRVLNSSTTVSHSTTSDLLVPSPNGGQTYSRKCSDSFLRFLKQELTLVELEAIIGAISVCAMKLWSTVFVFRPKDSTVTGFGSLSGASFNTDQAILTEHIIWKGPLWAARVLEVYGPAETGATSTTQVDADVGNNLIEEAVWRGTREEGARLAANGVARLLWKERQERIEAKASSAAEKISITDMRVNPSVWRGSSGDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUP9</accession>
    <name>A0A1C1CUP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA excision repair protein ERCC-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ERCC1</name>
        <name evidence="9" type="ORF">CLCR_08733</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUP9"/>
    <dbReference type="STRING" id="86049.A0A1C1CUP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08733"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05939"/>
    <dbReference type="eggNOG" id="KOG2841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="54"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="260"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT52218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="379" mass="41624" checksum="D800CA1FAF1BF6DB" modified="2016-11-02" version="1">MAEEFDSLDFHSGEASAERSSAPQRTTSPATNTASKVVQPKPQALPSRQGPSAILVSTRQKGNPILKHVTQLPWEYSDIPCDYVLGATTCALFLSLKYHRLHPEYVYSRIRQLGKLYNLRILLAMVDIENHEEALKELSKTSMINNLTLILCWSSQEAGRYLELFKSYEHASSASIRAHRAETYQESLTEFVTTPRSINKTDAASLIMNFGSLRAAVNAQPEELALVPGFGEKKVKDWYNTLREPFRVRRAAKSTAALLRQETTVDTTTSLDTDSGPETAREPIPISTVPSSHSQASKAVVTSSDTQMGPSHKRSRPEALEDDFGDDDDEAAWLALAEAEAAKASAEKEQDNSSFPAAQKEPELSSGVAAALAKLRQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUT8</accession>
    <name>A0A1C1CUT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09120"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="210" mass="22559" checksum="D1DEB8A9A2D2F83B" modified="2016-11-02" version="1">MSAGESFTDALPISGQPAIALAHAALIVVDSRRILSATMNHTSRSHPPSKGRVSEYITWCLRTCTLEQAKDLPNQNGWQEETTSSYLLPALSKTAPEVRQSNGSVPQCCCVSDEEALTPPLQVHPICGRCRAGGTDCVYDESALGRSSTRQSTSTSQQPSSAPMSYGRTEEAGLGGLHVARKYRLSGLVGIGRINDPDPSHRSCYETKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUV0</accession>
    <name>A0A1C1CUV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_08280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUV0"/>
    <dbReference type="STRING" id="86049.A0A1C1CUV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08280"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05899"/>
    <dbReference type="eggNOG" id="ENOG502QVPF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3989227at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="140"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="499"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT52265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="569" mass="63267" checksum="7B0F310EA2791E6B" modified="2016-11-02" version="1">MALLPNQKTCEKLCRFFFATVFPLVPIFHIKSFADDFWSFWDGVNPDDLHNSEPSMFIRRKPAFLSLLSAILFATLSAASPARLEQMFENPADINAGDIYFIAMVSATLTGFPRRPSILSLAAYIIAQSQFVREEEFSDAPDFIATSFRVALGMGLHRQLSESSFGAAELETRRRLWWYILHLDVMSSSSSGLSPLFINQKMASTEAISQYDPSDNDVGTRQEVDIRYLVASHRYAITKEMREILVLHFEDSFQTLEAVEECADRLRRTATQTTAAVETLLTVMTNTDSAASTVPQTSGPMHPDIGQTWTLRPSPNDKDIVNFAAWAALLLHLMVHKAYCVLYHPLFRDPAMVAHDSVRTNAVKHAQAFIQLFVRVCNDPISEPYHWMYPGTYQPLQAVSLLLADLLQHPHSDDATLSRGLIDAIFELYQVDEGIVSQHDPPRRQLSPSGRDAWTMLVRTRQRALQQVGMDHHVLFPSSIVASKRCICGERVSVDGHDMGSGTYQHGPTSGAGPSGQASVGGGEIESEPPGEMDQGDALQTPGEMLYDQADFDWHAWDSALGPSVGLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVA3</accession>
    <name>A0A1C1CVA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVA3"/>
    <dbReference type="STRING" id="86049.A0A1C1CVA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10980"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03828"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802:SF1">
        <property type="entry name" value="IP11341P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="141" mass="15472" checksum="829A35EF3EAC2137" modified="2016-11-02" version="1">MTSYPSTSNTTIPPPSSNPSVLLSYPTPAILLVTINRVKQMNSIPFPVHWHLHRVFDWFDREPTLRVAIITGAGPKAFCAGQDLIELGKRDPKELEEKPYLALHPPTSGFAGISRRLGKKPIIAAVNGFALGGGFEIVLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVS2</accession>
    <name>A0A1C1CVS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVS2"/>
    <dbReference type="STRING" id="86049.A0A1C1CVS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09440"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04031"/>
    <dbReference type="eggNOG" id="ENOG502QVDP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3548913at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064:SF1">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="831"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1456" mass="162664" checksum="9051CE28893F81C2" modified="2016-11-02" version="1">MSRPEIPEPRSTGSPPLRSSAREASAHYASRASHFEDQHTTLPMLKETVRGIRTSRQEESGDPDEEERTLGASSRELPFAHMRIHFADFARELRLHRHHEHRKRMLCHQRDRLRNAIALSARLQRVGSWVHDGLVQISQQSDPSGFTRVHQHMQDLVSLCQAQWHHEVHALDANFTSKTPSKEPFLAKLSTSSREDCLELLHTLRCNPRFLVDRFKAMNPDQVKGLSTSPKFKNLSESVLVSLSENRSREAQRRRPRSFLREYEDDAQLTRSKAYSKELEDYASSFERSNPLSFLIHNIYASSDDIESHESQLRLSTWSTICASLFTESMPAFEAIIGDVLSAFAHLHGWQIKERLQMFLMGSLQRGAFLYNSVEPSISKGRTDVSIFDSFYSTPQAQAFFDTEVRELFQILGSGDGGIPVGALRLGRAIVGKLPTLQSQSDFRGHFFFRWFLQDFLRIAMSFPEDENMLLQFHISPRARFHLLHKLWEHANARATDSVSSMPTQRVEEDVRNSVNWNIGQLDADQCINPYQAGHTPVTILGDFQPPYISICAADIAHLLEKLRPQTIHTSSPFDQFLSSSQATFNSQYSRAIPKFDRLCRRILDFIEPGHSSKNVHPCQESWALLLISPGGDLSIATPALAGDITTAGEGLGDLDPVQTAVLRLAASSLSLHAPTTVHQISDGKAKGRGLSEMFAEESRTSHIQTDSLTSMYWHNALNYLRTYYPLTVLTGDDTKVLGPILQRLNGRQILLANECLQLQQEVADLEASYACARTALATAADWLDKLRVKLWYAMAVTSSDAYDNARNITVALNNMAILARPGAISGQEYGGSPEPSRPGSSMTSASSIFDQPRIDTETIMKAPVEYGGPRKLSDAQIEKTKKWLERNHVENFCRGEERIHRFCMEVKLLIRKLVGDTIASSPVLWSSELFARERGLYDIHAGLYGGPSTRPPSVMSEPLSSTSFPLRPAFAGSRASIFGGSSRLGKDGLGSDISSYISSPGRATTSTTLESASIWSRTQSNSRSVTSVSQQSRPASTFEGSHLNRSVDRSPEKANFLETLRQDLSSLLLSDLACPVWSCGSESDAWMDAICQTPGIMERLHQRSALAHLLPPPNTTLACPASSSKGPRKHKQRSHSAAPHRSSSGKHDCDPGLDPVKKVPFSNGRQPRVDDFPYRSAFNDILCRVRDHTDPVLKLKAIRDFKLLSQDFQQNRGNGHETSPALPPEAADAQDGTRRRSLDPNILSANRRRNECSRSHVSAPTPTENEESLVVQSLKDLLHDLRPKTLFRDLQYIAAFASSDNLDDPELGQAFLHMGLAALAWKDEVCRSMVDVADRIVARDSIKRNISSAKKKREPSVLKAMEYWIVGAREGNAIAQRELASLYLTHPDVPPIVSLPLTLSSDIFKSDMMWEGEGEFRRNSQALCLALHWMQEAAKNGDVVAQMKLKEREAGRSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW36</accession>
    <name>A0A1C1CW36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_10238</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW36"/>
    <dbReference type="STRING" id="86049.A0A1C1CW36"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10238"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04067"/>
    <dbReference type="eggNOG" id="KOG3084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000042">
        <property type="entry name" value="Probable NADH pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="Zn_ribbon_NUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="255"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT52688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="422" mass="46944" checksum="1EC37EC1F23A71E9" modified="2016-11-02" version="1">MPAPPQPELPHPAHLDQDSALGRKFGKEVTNYFGGSPINRVSFLRDDNTFLAGAFSHPSARFLVFKTLSPLIKSPTEIHYATLDDLKSLLPTNPFDRTEKEIVDDFDSRIDYPQLVFLGLDEKVKDGFSFKNFTGAPHWAVDITPKKTFEKEAKELSDTFVASGLKFSEGMRAMSFPADVADHFDPNSQPAAEYAQGRHYLDWNFRNTFCGTCGHKTFSVHGGAKRVCPPKDKAETPQEREPCSTRTTLSNLTFPRTDPTIIVAVLSHDSKRLLLGRQKRWPPHWFSTLAGFIEPAESVEDAVRREVWEESGVKLSRVLVHSTQPWPYPANLMIGAIAQAASPEDEEIRLEFDPELEIAKWFTLEEIQEALTNGTSGLGDPAPEGYKEGNLRLPPPTAIANQLISAVVKGGFLEGVTPITKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXI5</accession>
    <name>A0A1C1CXI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PHB2</name>
        <name evidence="10" type="ORF">CLCR_10482</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy. Required for the switch to necrotrophic growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXI5"/>
    <dbReference type="STRING" id="86049.A0A1C1CXI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10482"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00214"/>
    <dbReference type="eggNOG" id="KOG3090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="9">
        <location>
            <begin position="54"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT53254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="309" mass="34026" checksum="D8B855779450B1FA" modified="2016-11-02" version="1">MSYDPREHFQQIQRTLQQRRGQGFGGLPGGGGAAGRGILALVGLGIAGVVLSNSLFNVDGGHRAIKYKRISGVGNEIYNEGTHIRLPWFETPIDYDVRAKPRNVASLTGTKDLQMVNITCRVLSRPRVEALPQIYRTLGTDYDERVLPSIVNEVLKSVVAQFNASQLITQRENVARLVRDNLTRRAARFNIMLDDVSLTHLSFSPEFTAAVEAKQVAQQEAQRAAFLVDRARQEKQATVVRAQGEARSAELIGDAIKKSRSYVELRQIENARNIAQLLQEAGGKNKLYLDAQGLGLNVGAGEFEGSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY03</accession>
    <name>A0A1C1CY03_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_09775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY03"/>
    <dbReference type="STRING" id="86049.A0A1C1CY03"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09775"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00274"/>
    <dbReference type="eggNOG" id="KOG1549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="3">
        <location>
            <begin position="62"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="580" mass="63875" checksum="ABB528C91C78B689" modified="2016-11-02" version="1">MGSFGEVTEFGHGFKSQFLFDPKYTNLNHGSFGSYSLPVRNALRGYQKLAEAAPDKFLRYQYVDLLDKSRERIAKLLNVPTDECVFVQNATSGVNTVLRNLQYKEKDCIIYFDTIYGAIEKTLASIVETNPQLQLRKVGHGQDFAYSLPCTHSEILNALSQTISRVLYDGLNPKVCVFETIVSLPGVRFPFERITKMCKEYGILSLIDGAHGVGQIPLNLSQLDADFFVSNCHKWLYTPRGCAVFHVPKRNQHLIRTTFPTSHGFVPKSSSSIRNPLPPTDKSDFVNLFQFVATADNAPYYCVPAALNFRQNLCGGEEAIYNYIRDIAQRGADLLAMLLGTEVMDDMDAGFGLRTMGSYEASDKRDGGRIGWAGGLRDCAMANILLPVTIVGAYSRGSISMGPGGAGSAGGLSPALRQSSYGFPSANTLSQMRSPSASSGGLLGEPRRSTSPLNSPSLHSAGPIIIQEADVPIHIAWMEKTLVDEFNTFVAIYEYDGKLWTRISGQIYLELKDFEWLGGVLKSLCERVRMGESLRGRAKTPEIDKVQFDALSLKSPVPSRQNTGDVLKKFDVTQGGWINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY39</accession>
    <name>A0A1C1CY39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_09527</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY39"/>
    <dbReference type="STRING" id="86049.A0A1C1CY39"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09527"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00298"/>
    <dbReference type="eggNOG" id="KOG0527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000041">
        <property type="entry name" value="HMG box family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF320">
        <property type="entry name" value="BOX TRANSCRIPTIONAL REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="151"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="151"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="577"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="869"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="577"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT53330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="912" mass="98401" checksum="E8C5AA139562D9BB" modified="2016-11-02" version="1">MHPVTDSARRDKEAEQVAGICDNRLPNLPAWYRLLPKPAAERYPALRRTSSLSQHHLFHDRSQDRAAAREDGLRRDTDHVPAHKGSMSTAATSQECIGELQIPANGHSGSASSPVRERSLEMAETGTEPPVGRSSSNPKENVCLCPASPKIPRPRNSFILFRQHQQASIIAQNPGIPNPEVSKIIGEQWRGLSAEAKEEWNLLAEEEKARHQQQYPGYRYHPRRNGRVSNQSSVSGPSSAEPQEPCAKCGGKPINHYNNPTPVYIPPASTAQQAMAVNVPTKRGYVVSAGPPGQRISPDHAGFQRVDPRLVYALPPAGQPLPTPPSADSQDAKRRRLGNGVYVSAREVYPEATYSYLHSPTTNGAYVRQEVLHPSHIQHVQVPKPQMVSPPRAYPRPPALQPIRPPHPHQRNRSSVALPPIETLVSQTPTKASMAQVQSSGVEAMIMSIPVLNKIKVLSQLAGPLPPPGITSPKPGVRGAIIAVEGLDATSVNSMTNSLTEQLEKEGKFAVKIFRGPDPYTLLHEARTGVQGQKRGTDAYLKLMTRWHEVNQKIVEYITSRPGVGSATILSDNHTDHRVSGVEEHHEPPETPDKVVRSEAPRQAESGSDREEDNLDSAVSPKTTFIRAADPSAMSPPSKSTLHKGRSLSTPGLWTSNEPPSSALDTRPPASSYTRPPNSKRIPPPPPTPPPASSLPSRVSTSKPPSRSPPPMATPATINTGNLPPPHPTTSNTINSPGSTPIPVAIVPHFQLTTVDASSISMPIHDSFSPPAHWQWFATMWRGSVGPDITIVVRGVDEEPAEGSDVSKPASLPGISGVANAATASARERIPSVASSQSHSGGTGVEIRLHDSRTVIVKTGIVGSAISTTGGVGSGAKSHSKEMTPAQQAKEVENWQKAKRRVGFEVEEFLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYI2</accession>
    <name>A0A1C1CYI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein bli-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYI2"/>
    <dbReference type="STRING" id="86049.A0A1C1CYI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10846"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00559"/>
    <dbReference type="eggNOG" id="ENOG502SK2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="2">
        <location>
            <begin position="31"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="203" mass="22864" checksum="F557607949711A21" modified="2016-11-02" version="1">MPEPLHANEVNTQTDPSVAKQYDRETPKEQQWKELYEMIDGKKISILSTYRAGVGPVGRSMGVAKRVGPDILYLANKHSRKFSDMDKNKEVQITFQDSKTQDWISITGTATTTSNDDPRIKELYSSAVSAWFGDLKDGVHDGTWKDPRMSLIEVQSKYIVYWKKETSALGFMKEVGTAALTGGVAQTGVQRELSEEDIRKERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYN3</accession>
    <name>A0A1C1CYN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HEXO2</name>
        <name evidence="12" type="ORF">CLCR_09823</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYN3"/>
    <dbReference type="STRING" id="86049.A0A1C1CYN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09823"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00475"/>
    <dbReference type="eggNOG" id="KOG2499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF58">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651134" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="226"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT53510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="631" mass="71344" checksum="8E539F7141877B48" modified="2016-11-02" version="1">MLPRTLLGILSILVSPCLAIWPQPAEIKTGTRVLWLDTALQATLRCDNGEDRGQDQDYILYNNHLTQLLGGMSRYAQGFMDKLPFTLPGKSRNWEVDFSESSIVEDAVRDTIKSIHRSKFVPWKLHKRNTTYEPDRSAPRQYISRLQIQQRHCPPPERFRPSSFFGGDESYEILLTNGTAFITSNSSIGTIRGLQSFQQLFFAHSALSGAYTPFVPVKIADRPEWRHRGLSIDIARNPFEPQDLLRTIDGMAMAKMSRLHVHATDSQSWPIEIPSLPELAQKGAYHPGLVWTARSLREVQMYGASKGVSVYLEIDMPGHTASIAHTYPELIAAYNELDWSTFAAEPLSGQLKLNLSAVDTFISTLLHDILPRTRQYTSLYHVGGDEVNLVAYTLDETVKSDNPEVLQPFLQRLIDHVVGTSIQFGLQPIVWEEMLLDWNLTLPSAGPEDPTTQTLVQVWRNSERIEEVLKRGHRAIFSDYHHWYLDCGYGVFLDPYASGKSPPGVPYNTSGGFSSRLKKPYLDYCAPFHNWRHMYTYDPVAGIARELHNSIEGGEVLMWSEQTDSQDLDSKLWPRVAAAAEVLWSGTRNESMLEAATSRLGEWRERVVVDLGIRSSPVTMTWCLMEGGCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYW3</accession>
    <name>A0A1C1CYW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">High-affinity fructose transporter ght6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ght6</name>
        <name evidence="11" type="ORF">CLCR_09710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYW3"/>
    <dbReference type="STRING" id="86049.A0A1C1CYW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09710"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00635"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="60"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="546"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT53692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="586" mass="66195" checksum="0EB00CE969A8685F" modified="2016-11-02" version="1">MGYLNKFHRPELTRQSLGLTNWVKYDKYNPHAEGATDARKSLANLDYSPLRRVTMASFLMGIAISMGGFIFGYDTGQISGFLAMPDFLERFGQRHSDTGEYFFSNVRSGLIVSLLSIGTLIGALVAGFVADVIGRRLSVTFWCVIFSVGTIVMISAEHRWYQIMMGRWVAGLGVGALSLLVPMYMAETSPRHIRGSLISTYQLFITFGIFFASCVNFGTYEHQRDNSGSWRIPLGLNFPWAFILGGGILFFSDTPRYLYRKGHKEEAKRIMEKVYGAPPNHYAIHVELEEIEAKLRAEANKEGPLAEWFHMFRAPKMAYRIALGMTLQMFQQLTGANYFFYYGTVIFRATGINNSFVTQMILNGINFGTTFYGLYIVEHYGRRKSLMVGSLWMFLMFLIFANVGHFSLDKQDPQRTESSGTAMIVMASFFIFGFATTWGPMIWTICGELYPSRYRAKGMALSTASNWLWNFLIAFFTPFIVGKIDFLYGYVFAGCNLVAIPLIYFFVVEGQGRTLEEIDTMYILGVKPWKSSTWVPPPPEEIAKIRREAGTAEGLDEAGEIAPAGDRTSDESNMEKEAEKEAEHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ96</accession>
    <name>A0A1C1CZ96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_10630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ96"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10630"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00788"/>
    <dbReference type="OrthoDB" id="4296327at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="241" mass="26820" checksum="731AA611BF27CFC5" modified="2016-11-02" version="1">MMPQTAKRQPLSCENCRKRKIKCSGERPFCQTCVRRGFSQTCFYLRQPIQTPSASNPDEVLQKLNRIESLLERQGHLLEQRYDLAPNAFSSNQDSQSQRQPSSLNSSPWNEVDAGHSDVADTKTVGAVLMYGSGYERFVPGIASADAEAVNELIQATSAPPMATGFPFADEAIPSPQALLDHLPPFRQRDQLKDIFFEVYSPECLKPWDTSVIGDAGPILGAEILKDEKMHVPLLPGSWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZF4</accession>
    <name>A0A1C1CZF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial translation optimization protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MTO1</name>
        <name evidence="8" type="ORF">CLCR_09727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the MSS1-MTO1 complex that catalyzes the 5-carboxymethylaminomethyluridine (cmnm(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZF4"/>
    <dbReference type="STRING" id="86049.A0A1C1CZF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09727"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00811"/>
    <dbReference type="eggNOG" id="KOG2311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3329at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000145">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="7">
        <location>
            <begin position="590"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="690" mass="75841" checksum="FCD01F47BBB1FFAE" modified="2016-11-02" version="1">MKLVLRPSGPLAWGHTPRTRSRILRQRRSFAAVAGDIRPYDVIVIGGGHAGTEASAAAARSGARTALVTPSFSNLGVCSCNPSFGGIGKGTMVREIDALDGVAGRIIDRAGIQFRMLNVKKGPAVWGPRAQIDRDLYKKYMREEMLSTPNLSVVEGKVADIIVSRDQIDSTDTITQGRITGIRLEDGRIIPASHVVITTGTFLGGEIHIGLEAYPSGRMGEAATFGLSKSLRSAGFTLGRLKTGTPPRLDRDSIDFRALQVQPGDSPPTPFSYLNDTVEIGDKGQLNCWTTYTNEASHQIIRDNLDKSIHIRETVRGPRYCPSLESKIIKFRHKERHMIWLEPEGLEPNKVIYPNGISMTVPADAQYAMLKTVQGLENVKMLQPGYGVEYDYIDPRNLLPTLETKLIKGLFMAGQINGTTGYEEAAAQGIIAGINAGLSAQGKEPFTLSRAEAFIGILIDDLITKGVSEPYRMFTARSEYRMSCRADNADLRLTEKGREAGVVSDKRWAHFSETRGQMAELQRKLEEVRYPSTEWVKMGFPSRIDSNRRSAFDMLRVSGVDISSLAEKVQTLPGIDNYEPKIKTRVSIESIYAPYISLQQKAAEAFARDESLALPADLDYDSVFGLSIGEREVLKLVRPASVGMARRVEGVTPHGALRLLRFAKKNSRKLPAEEMVLEDDAVLGQVDASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZV0</accession>
    <name>A0A1C1CZV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10817"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00816"/>
    <dbReference type="eggNOG" id="ENOG502SSHD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5396546at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058931">
        <property type="entry name" value="SnoaL_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26528">
        <property type="entry name" value="SnoaL_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="216" mass="24230" checksum="0EBA22BF7FFAA79C" modified="2016-11-02" version="1">MASASTPGSEAVHAQLKHLYHTYRHTQHIPSKASFFSPTCMQVCRTIPSYAAVKRDTIIQYLLEAAGFQDVESYERAQSSSTTTASRAAEAPDDEERRSAPVKVKALTGKSYYSIRPLNATEESEVLPEDVVAPLGMTPSQLNELRQTENWVGMRVDLWEDNDNGDSAGAGRLIKVKYWWRQEHVDGELKWLQCLHDIMSIGERDGSEDKEGEVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0A3</accession>
    <name>A0A1C1D0A3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urease accessory protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">UREG</name>
        <name evidence="8" type="ORF">CLCR_00319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0A3"/>
    <dbReference type="STRING" id="86049.A0A1C1D0A3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00319"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10176"/>
    <dbReference type="eggNOG" id="ENOG502QR6E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10063137at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000208">
        <property type="entry name" value="Urease accessory protein UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="54"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="274" mass="29527" checksum="ED3B046C1B08FB6C" modified="2016-11-02" version="1">MTTHSHDNEPSHSHDHANGEPHGHTHEIYNGPGSFLHREMPIVEGRDFRDRAFTVGIGGPVGSGKTALMLELCLALRKEYNIAAVTNDIFTREDAEFLTKHGALTPERIVAIETGGCPHAAVREDISANLLALQGLHAKFQTDILLIESGGDNLAANYSRELADFIIYVIDVAGGDKVPRKGGPGITGSDLLVINKCDLAEAVGADVDLMEREANKIREGGPVVRAVIKNGVGVRDTVEMILSAWRSTAGYAVSRTRWKAGHVRGSGEQPTVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0N1</accession>
    <name>A0A1C1D0N1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0N1"/>
    <dbReference type="STRING" id="86049.A0A1C1D0N1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00915"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01669"/>
    <dbReference type="eggNOG" id="KOG0185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="252" mass="28175" checksum="9842800E7083FB9E" modified="2016-11-02" version="1">MNHYPQAWGRPRDDVYGPYDSSYLQTSMPQTHTQSPAVTGTSVLGVKFNGGVVIAADNLDVKRLRTFPPNTVVGFGGDVSDMQYLDRLLQSLDIRENYLSSTGHSLNARNLHTYLSKVMYKRRSDFDPLWNMLLVAGLDEQEKPFLASVDLLGTTFSAPTLATGFGAHLAQPLLRKLMPKDEESVQDVTQEQAVDAIKECMKVLFYRDARSLDKYSIAVVTKDGVKLSEDEKLENQSWAFADQIRGYGTQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D114</accession>
    <name>A0A1C1D114_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Maleylacetate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tftE</name>
        <name evidence="5" type="ORF">CLCR_00891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D114"/>
    <dbReference type="STRING" id="86049.A0A1C1D114"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00891"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10113"/>
    <dbReference type="eggNOG" id="KOG3857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3360544at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018506">
        <property type="term" value="F:maleylacetate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08177">
        <property type="entry name" value="MAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034786">
        <property type="entry name" value="MAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF105">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="3">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="4">
        <location>
            <begin position="168"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT54543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="360" mass="38580" checksum="F1C8468C8CECCAEE" modified="2016-11-02" version="1">MDPFEYNANPGRVVFGKGSIQKLPDEIRRLGFSSPLILSTPQQVSQAEDLAKILTNASIEPAGIYTNATMHTPSHITEEAMAFIQDKSADCVVSIGGGSTTGLGKAISVRTGLHHICVPTTYAGSEMTPILGETQDGRKTTRTDPKILPGTVIYDVDYTMTLPTGLSATSGVNAIAHAVEALYAKNKNPIISLLALEGTKALAESLPEIIQDSKSQPAREKAQYGAWLCGVCLGSSAMALHHKLCHTLGGSFNLPHAETHTIVLPHALSYNAPAIPEAMEKLASVLPGSEGDATKGLNLLLEKLQVKRALKDYGMKEEDIDKAAEIAVSNQYPNPRKVEKEPIRELIRRAWAGEPARADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1C2</accession>
    <name>A0A1C1D1C2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein PhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1C2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00962"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01762"/>
    <dbReference type="eggNOG" id="ENOG502SWYI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5430620at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651195" description="Cell wall protein PhiA" evidence="1">
        <location>
            <begin position="21"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="20617" checksum="00780F8070278FF0" modified="2016-11-02" version="1">MVASSLFAGVISLFALGASAAPKALHARQTTTTTTGTENIGLYLDSDDFDINSLQTLRVSYANTSAYIGQIKYEAYAEPLVIGAFDDGDQNSVSFLSIHQSPTGYQQMYIIADETQPVGFSVPHGSAPQGVTTSGFSFGPEGALLNGGVNNFYACQNAQQAAMNTWQIWWFGAGQPNAVGCKGPIKLVAGDACARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1D1</accession>
    <name>A0A1C1D1D1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative serine-O-acetyltransferase cys2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cys2</name>
        <name evidence="4" type="ORF">CLCR_02793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1D1"/>
    <dbReference type="STRING" id="86049.A0A1C1D1D1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02793"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04780"/>
    <dbReference type="eggNOG" id="ENOG502QR3J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="146"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT54673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="637" mass="69544" checksum="3A6F2296C3326F44" modified="2016-11-02" version="1">MAVPRGAQIAARLLSRGSKPLKSNAAATLKSPVRGTRWQIRNAASLHTRAPRRAQAASAVRDEENYEPPVSSNPAMSFPCLDAQEQKTAALQTRSLASGPEPSYTTGSHMVFHSDEPILLDWGGILPEFDIAHETWGTLNADKSNAILLHTGLSASSHAHSTEANPKPGWWEKFIGPGAPLDTDKFFVICTNVVGGCYGSTGPSSTDPSDGQRYATRFPILTMDDMVRAQARLLDGLGITKLYASVGASMGGMQSLAFGVHFPDRVGKIVSISGCARSHPYSIAMRHTQRQVLMMDPNWNRGFYYDGIPPHSGMKLAREIATVTYRSGPEWENRFGRQRADPSKPPALCPDFLIETYLDHAGEKFSLEYDPNSLLYVSKAMDLFDLGWAHQEATRARRQENQAKLSRVRSGAPGPQSDPSCSLTLPSKNYEEQVSTAPMDEAVDAGHGGPPLDLVRGLAGLKDHPVLVMGVASDILFPAWQQREIAETLRATGNQKVTHFELGEDISLFGHDTFLLDLKHIGGNPQDFSENENKHHADEDPTLLHVAPHTHISDNADGVSGGQTCETNTEAGGEVHESREQAVILLWRRTHVSSNEDGDNQGVYGDDTGHDDGDQGLSRMHQHPRKAWMSPLADLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2B4</accession>
    <name>A0A1C1D2B4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2B4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03069"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04917"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="294" mass="33537" checksum="2ABB8F74F7D3E05F" modified="2016-11-02" version="1">MASVARCDHAKARRLGLLDLPPEVRHEIYRPLFCHKPSPITLGVQDFFSRWASFSPADELQEPTFYTALFRVNKAISRDALQYAYSANSFRFDRDIETFCNLGPVALASIKTLRVYKNAWLNSSYATSFWQTINQCCSSLELLVVEAASHVLLSAIPYLGHLTASIPARQAKPRLILDLTVLDRHFSFDFPDREYQSARQDLEENMRNKDSADYPPRPQYTYVMRLPRHVKEIRFVLDMGPGAFRALEGTLKEATDLFFVESDDIPPVAGDGIEGRGIRHCFVWQETGAQVNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2C3</accession>
    <name>A0A1C1D2C3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sarcosine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_02968</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2C3"/>
    <dbReference type="STRING" id="86049.A0A1C1D2C3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02968"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04963"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="431" mass="47614" checksum="2265A929D90C65CE" modified="2016-11-02" version="1">MDSTDSAQCDVLIVGGGIFGTSTAYHLSKSHADPSRITVLDRALVPSSQAASSDINKIVRADYTKAFYMDLAYEAMESWTEDPILKPYFHQTGWVMVDEKGSDLADRIRKNFRESGRLDPSADLSLEDVKTRWGGVLSGMDTTGYDKAYTNSSAGWADASGAVAALMHEAVKAGVKQEVGEVTELLSTGEGLVGVRTADGRVFSGQKIVLATGAWTPYLMASFEQKIHISPGDSIQRQIKATGVCVAAFQLTGAEAEHYSQMPVLIYGAKGEVMPPNRDRWYKFTNANTFLNTQPHPETGQNISVPSSDQKSVPESLKRQSIEIIRQRVPEILDSGRTPDDWRLCWDVISPDQNQLITQHPDPRLSNLYFATAGSFHSWKFLPNIGKYVVNVLNGKSNGKDKDEAWCWKRKWDGRGAHEKTLPKGELTDYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2G5</accession>
    <name>A0A1C1D2G5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2G5"/>
    <dbReference type="STRING" id="86049.A0A1C1D2G5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03090"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05094"/>
    <dbReference type="eggNOG" id="ENOG502RDU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651273" description="CREG-like beta-barrel domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="2">
        <location>
            <begin position="73"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="272" mass="30268" checksum="642171D837406E8B" modified="2016-11-02" version="1">MKLPSTSLALAAVQLLTLSHNLASCAPMIEEDTSAASLDLQRFQVQTQPHVDAFKDQGQDQDDLDASSIPSRYQSTLLARRLLHLSSHGDLITVFPTAGNLSSRIPPSVASTPIGLPEYIATCEEESHHAADPTILSLKISTATRNAEAGSNATLSLSWWDEYIHRTGRAPFALANLPRLSLTGYLEEIPAEDRAARALETCFLKKHKDSVMWLPGRKWAAHEGVWTRLVVQQAYWIGGFGDKNYIGWLDPEEWRAVRREEWEDARLPGEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2W5</accession>
    <name>A0A1C1D2W5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_02987</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2W5"/>
    <dbReference type="STRING" id="86049.A0A1C1D2W5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02987"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05084"/>
    <dbReference type="eggNOG" id="ENOG502QRM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5350673at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="398" mass="44227" checksum="A531B60C299E63E0" modified="2016-11-02" version="1">MPSRQFHHKSRHGCANCKQRKIRCGEERPSCANCNRLGGRCSFLESDASGGPLVHSSPGSSAGTPQASAAGTHSSHERTDDLEQYDDALIIRWSEATCFTMTDRWETFPVWEVSVPALASDQPFLRHGLLALASMHVRYTSPPLLQSRYLDLATQHQALALAGYIPELRTITPGNCHALFAFSALLLPIRYSFISAMDGEIDPENVLGEITSVFDYGIGATIIASQGAGWLQAGVLRPLMDRTTAPGDMLLYLVKEPQDALRSLMAYVEHVARESESNNSSEILANIPIYVRSIEMLTNAFPSEDAERRIFDDMIGWPHFVGGDLVRLLRERDQMALVILAHYGVALHAFSGFWWLDKVGARLIHAISRMLRPDFLALVQWPLNRIAVEQASQHMSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C652</accession>
    <name>A0A1C1C652_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">NADH-ubiquinone oxidoreductase chain 4L</fullName>
            <ecNumber evidence="4 16">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">nd4L</name>
        <name evidence="17" type="ORF">CLCR_11477</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="17"/>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Mitochondrion inner membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="4 16"/>
    <dbReference type="EMBL" id="LGRB01000023">
        <property type="protein sequence ID" value="OCT43962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C652"/>
    <dbReference type="STRING" id="86049.A0A1C1C652"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11477"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030964">
        <property type="term" value="C:NADH dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3510:FF:000004">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase chain 4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004320">
        <property type="entry name" value="PRK05715.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434:SF16">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 16 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 16" id="KW-0813">Transport</keyword>
    <keyword evidence="12 16 17" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT43962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="89" mass="9803" checksum="A1222C029011DC56" modified="2016-11-02" version="1">MSFSLILFLIGILGFVLNRKNIILMLISIEIMLLSITFLILISSLSFDDVLGQTFSIYIIAIAGAESAIGLGILVAYYRLRGSIAIEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6F2</accession>
    <name>A0A1C1C6F2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6F2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00148"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="98" mass="9279" checksum="331E1064D476FBA3" modified="2016-11-02" version="1">MLRPPQVPAQAQAPASFEGAARVKKPAGARGGMRGGRGAPRGRGAPGRGAPRGRGSFGGGSFGGGRGAPRGGGRGGFSGGRGGGPRGGGFGSRGRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6Y2</accession>
    <name>A0A1C1C6Y2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative transcription factor kapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_06218</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6Y2"/>
    <dbReference type="STRING" id="86049.A0A1C1C6Y2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06218"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06990"/>
    <dbReference type="eggNOG" id="ENOG502T0QK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="112"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT44295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="235" mass="26890" checksum="2F9C60E3C381AF36" modified="2016-11-02" version="1">MDFGFVSSPSQSPSQSLFTAGQYFDSTSEGSSPNSPHKQMSQMMFNSASMQYDMYQYGTSQASFYPTTQPTKIPAEYNAATVDQTDRRRRRSGSTSAATAKDKESIPNMHMRRRAQNRASQRAFRERKEKHVKGLERQLEDLHEKHQDLLQSYTRQADEVSKLNGRISELTVELNALRSCQDQSFSEMLMPDKFDKFDAFSTPDNMLYNGPECYFDKNAVDLNSEFALHSFEDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C750</accession>
    <name>A0A1C1C750_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-rhamnose-1-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DHG2</name>
        <name evidence="5" type="ORF">CLCR_06168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C750"/>
    <dbReference type="STRING" id="86049.A0A1C1C750"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06168"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07037"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="290" mass="30253" checksum="FAFB79C48FC15D99" modified="2016-11-02" version="1">MTLPPLLAGQVCAVTGGLTGIGRAITILFLSHGAKVAINYLASHNKDEDQLLTSLRTDAFDAIKARSSSSSSSSTAAAAGAGLHNLEDVPLLTVPGDISLPETGQSLVEQAVAKFGRLDTFVSNAGICKFEEFLDISPELYQSHVSTNLSGAFYAVQAAARQMTRQTPQGGSIIGISSISALVGGAQQCHYTPTKAGILSLMQSTATALGRYNIRCNALLPGTIRTQLNDDDLKDGSDKKQYMEGRIPLGRLGKPDDLAGPALFLAHGELSGYVTGAAILVDGGAFVNFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C768</accession>
    <name>A0A1C1C768_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative NAD dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C768"/>
    <dbReference type="STRING" id="86049.A0A1C1C768"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06064"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07068"/>
    <dbReference type="eggNOG" id="ENOG502SNJP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="308" mass="34867" checksum="88207AAEF22C6F23" modified="2016-11-02" version="1">MLILIVGVTGNIGQKLIEPLRQRGAQVRGLARHKSKMAPGKLQLLESFHDMEAWHDVPAIRKALQGVDAVICAYGPVPELVLEGQLLLVRLMEEQGISRFMPSAWNLDWTALDWGDIVYYDLFLATQRQLAMSSTIKPFYIFIGFFAETFFSLPGHGVFNPATHGVWDSNNGAPKAEYWGTGDEKWQITTEQEAAEFTAALICDEAREPGVYRYCSWEYSIKEIAAIYEKEKGSAVRLECQGTAEDLKKTAAASQQELGLSRFWLWMGYTYQIHQMSQKTMMSKLDNKLYPDVKSIGLGEFLRMHPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7W1</accession>
    <name>A0A1C1C7W1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Golgi apyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">YND1</name>
        <name evidence="8" type="ORF">CLCR_05537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7W1"/>
    <dbReference type="STRING" id="86049.A0A1C1C7W1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05537"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07296"/>
    <dbReference type="eggNOG" id="KOG1386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24039">
        <property type="entry name" value="ASKHA_NBD_YND1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="492"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="652"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="658"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="183"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="737" mass="80882" checksum="6124FBFFCCFEA436" modified="2016-11-02" version="1">MVHGDNERYGIVLDAGSSGTRVYIYRWLGNSVARLEASSPPTLPELETKDKWTKKVHPGVSTFGGTPELVGPDHLQPLLEHALKYIPQDAVPETPIFLLATAGMRLLPDHQQKALLRNICSYIRSETEFSLPDCDVHIQVITGETEGLYGWIAANYLLGGFDSPEDHQHGKGHHTYGFLDMGGASAQIAFAPNATEAEKHANDLTLLRLRTINGLPQEYKVFVTTWLGFGANEARRRYVQDLEESYAIDGVLEVPDPCLPTGLRLNFDGTIISDEGPSSSNHYLRGVGKFDECLRRTFPLLEKDIPCPDEPCLIHGVHVPAIDFKVNHFIGISEYWHTTHEIFEMAHKDKAYDFNTYQQRVKEFCEQGWSDIQQSVADHVYGKKVDDKTALEVCFKASWLINMLHDGIGIPRVGLEDTNVSDHNGTKEVLQSGKDKGFLDPFQAVNEIKSTEVSWTMGKMLLYASAEIPPASKDGLPVGFGSNVPGVPDDFQYPSGGRLQSIPDPGSGSGSSDSSGGVQSITDTIHDTLFKSDAPHRLPGFIFFLLILIIATFYLCGRDRRSRVYRSIYPSYTPSIPSSAPTSHAFSPSPSTTPKLRNPLTFLNRLINGRKGPLRHHWHDLEDQRLYNPADFELNDFSDDEGGLLDADKAFGHSRTASRPTSSHGRSSSSSPRDKRSPNGTGGGGGGGGNPGKLRPAAIDRAGLVVRTESRESLAPLAAANGRSKSKSRGASPTRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C856</accession>
    <name>A0A1C1C856_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C856"/>
    <dbReference type="STRING" id="86049.A0A1C1C856"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06066"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07381"/>
    <dbReference type="OrthoDB" id="6365728at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="345" mass="38111" checksum="4D29F60A82AB5F1D" modified="2016-11-02" version="1">MATAYFAGLPETASDVSVAVWLGANLPPKPFLSRSRNYQAADALSVQDPVATSNSLERIGFKRVPITNSPCSRYLRLAISQHVIFKAIHESVWQPLFSQHLWKCTKDSHATLKEIYSGLATEGPDFQHDWKVSTLKMLGRFDEKADVDHLITETVEGKVVNPLKSLLDRAHIESFRNDLKALLTDAIALGREAERDQSPLYVDTSPSLLKDSNGWKEYLSSSEEYDTSDGADPSVASPGSDFDPKALFVSPKIFREMMEIGSETKATASFKLELIQVGVALFPDTGIFHEGEMEWNRIRSTIKEAARSTGGWMRRSSTSTTATGLGISPISPSKNWPQQGPQGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8B1</accession>
    <name>A0A1C1C8B1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8B1"/>
    <dbReference type="STRING" id="86049.A0A1C1C8B1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05920"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07398"/>
    <dbReference type="eggNOG" id="ENOG502R8TZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4539697at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021889">
        <property type="entry name" value="DUF3500"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489:SF1">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12006">
        <property type="entry name" value="DUF3500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT44717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="426" mass="48160" checksum="AA01ABA0249E4307" modified="2016-11-02" version="1">MADSTPASAYREYLPDLSIPRFTTMAKQDAHVYADAFKESGIPPWIHALYKHWLELLKEPFKGVTSDGTVRHDLFKIQDEGIPMADIVSKTETLVSHLSAAPTARLQYHIDSPEWRTWSNPEFLLSDKGIRLDELDPSVRDDVLAVLSATLSPEGYEKAISAMRINGFLGELVNGTAVMNEYSYNFVLFGTPSTTAPWGFSFYGHHLCLNVFLYRAQIVVSPWFTGAEPNIIDQGPYKGTRILHEEEKLGLQLMQSLSATPDVQAKVQTYKAMRDPAMPEGRWNHDDQRHLCGAYRDNRVVPYEGVVVSTLGQHQQDLVTAILTQYLLYLPEKARAIRLAEYQAFYSDTYFSWIGGFDNDSPFYFRIQSPVVIVEFDHHSGVFLTNKEPAKFHIHTLLRTPNGGDYGMALRPLCAGTVNQNFVWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAA3</accession>
    <name>A0A1C1CAA3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvH</name>
        <name evidence="7" type="ORF">CLCR_06321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAA3"/>
    <dbReference type="STRING" id="86049.A0A1C1CAA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06321"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08073"/>
    <dbReference type="eggNOG" id="KOG3373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="68"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT45445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="172" mass="18855" checksum="00EF2A39FC15DFC0" modified="2016-11-02" version="1">MSSSALGRLVPTFSRYSVKQVASLRSSINSHSCQWQQPRRAFSARSALLVKKYTEDHEWIELDSDGKTGTIGITAYAAKALGDVVYVELPEIGMDVAKGDTIGAVESVKSASDIMTPVSGKISDHNKLLEEKPGTINKSPESEGWLAKIEVTDLNELDALMSKEDYDNFEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB58</accession>
    <name>A0A1C1CB58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB58"/>
    <dbReference type="STRING" id="86049.A0A1C1CB58"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11233"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03596"/>
    <dbReference type="OrthoDB" id="4161259at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="245" mass="28248" checksum="11F7BAFDFE4132A7" modified="2016-11-02" version="1">MARGLSQEMRREERRAKRERRKARRRERAQHSQSLQQQSSKLSKETKVKAEEIGHHLDLVAAAGKEFCHKLEAFSCDKHAQGHDLTDAAITRLAMACPNLQTVKLTSTTKLTDESVLAFLTLCPGLHTLSIVGNYPTKGNITGKLAFAELRQNKALGKHLHTLKVVDQRVDEDDAMRLSRARKNLVVWRRYVIFHAGEVVLDYKDLSESESEDESADEGEYEYGDWLTFWDIQDALPEWERWHHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBA7</accession>
    <name>A0A1C1CBA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">G2/M phase checkpoint control protein Sum2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_01470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBA7"/>
    <dbReference type="STRING" id="86049.A0A1C1CBA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01470"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03649"/>
    <dbReference type="eggNOG" id="KOG1073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="3">
        <location>
            <begin position="408"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="4">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="548"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT45757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="583" mass="60282" checksum="FED12D04829B9D18" modified="2016-11-02" version="1">MDMDHLIGQRFNLISKSEIRYVGTLHEINPEQSTIALENVFSFGTEDRKVEKFVPPSQQKYGFIVFRGSDVKDIKIAEDEPSQPSPPQSIPNDPAILNASRPGAPPLGPPRDGPFSPQEYPHPPPFGGYYPPGQFGRGYGPPPGGFGPGPGFPPYGPPPPGYFGPPGGPGFPQGPGHHPFPQHPQPPIGPPGLRNNLPQPPPPSRQTPASTTPADLPASGLTSELPGSNKASESTSPAPPKDAQAAASVPSRAPQAEIATKTAPTAAPGPAAAAAAPAPTKTAPTGPKSNRVTPAVPLTVNQKSFTPPVPAGDASAANGGAAKPQKPVTSQAAMDEAARQAKEAVAAAMAKLNPQAAAAQNKTSSATAAVDALTKKVAEISTATAVNGTSRGGRGGSRGGRGNFHRGSGQKKMEIPKSDFDFESANAKFSKEDLIKEAIASGSPLEEPPTKEDSAGDAGISSPPRKESLPTAGPAYNKSTSFFDNISSEAKDRTEGSDGRAIGRQIRSEEFKKNIETFGQGNVDGGYRGRGRGGGPGRGRQYGGTYRGGYNNRGFGGYNNYRGNRGRGGQSQSQAQGQAAEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBC0</accession>
    <name>A0A1C1CBC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CLCR_01513</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBC0"/>
    <dbReference type="STRING" id="86049.A0A1C1CBC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01513"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03669"/>
    <dbReference type="eggNOG" id="KOG1147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="14">
        <location>
            <begin position="34"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="15">
        <location>
            <begin position="344"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="464"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT45777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="558" mass="63388" checksum="FE7F86445539818E" modified="2016-11-02" version="1">MTDKSPKVKDASGSKGKKAPKVKQMELPNAAAGVVTRFPPEPSGYLHIGHSKAALLNDYFAHIQYPGGKLILRFDDTNTEKENAEFQDAIREDVALLGIQPDVISYTSDYFDHIDEYCVKIIQAGKAYADDTPGDVMSAQRLAREPSVHRDASIEDNLARFEEMKKGTEEGKRWCIRAKISHANDNASLRDPVIFRCPKTQTPHHRTGDKYKAYPTYQFACPVVDALEGVTHALRTTEYNDQDAQYKWILKALELRPVYIWTFSKIQFVRTLMSKRKLTKLVNAGVVSGWDDPRFPTVRGIRRRGMTVEGLRDFMVSQGPSKNVVNMDWHTIWTMNKKVIDLKAARYTAIDSNHVVCKITNLPQDGPYEETKPKHAKYDLGDKKVVYSQNILIEQDDARTFAKDEEITLMNWGNAYVRDIEYSNSTASSTTADGVADGVSNLGNVSSMTLELHLEGDFKATKKKITWLSKDQDLVPVELVDFDHLLAKDKLTEEDESHWEDFLTKQSEFKTEAVADMNVWDVKVDDFLQFDRKGYYRCDRAPTKEAKGVFFKIPTGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBH5</accession>
    <name>A0A1C1CBH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial import protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBH5"/>
    <dbReference type="STRING" id="86049.A0A1C1CBH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01742"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03718"/>
    <dbReference type="eggNOG" id="ENOG502SBHA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5529571at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013262">
        <property type="entry name" value="OMP_MIM1/TOM13_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08219">
        <property type="entry name" value="TOM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="141" mass="15416" checksum="DC3A0F558B10A05F" modified="2016-11-02" version="1">MSRSDQSPSPPQDLSGSQLTIPSDSEAYSSLSPPSSSPPQSSDNNGTRPVIIYQPPTIWSILRGAAINLILPFVNGMMLGFGELLAHEFAFRLGWNSTNIWPRHRSSRPVGPGVEMRDDPVERRRRNSTLNSGVEDAASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBT1</accession>
    <name>A0A1C1CBT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5'-hydroxyaverantin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adhA</name>
        <name evidence="4" type="ORF">CLCR_00461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBT1"/>
    <dbReference type="STRING" id="86049.A0A1C1CBT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00461"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10012"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF31">
        <property type="entry name" value="CHAIN DEHYDROGENASE_REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="322" mass="34798" checksum="28B72065A5268ECF" modified="2016-11-02" version="1">MQPYANNGPVNTDVDFDTSHVKGKTAVVTGGANGIGESYVRALTKAGAFVVIADLDTEEGTRLEKEFEGSAKFVKTNVTVWADQLAAFKTAISSSPSGRVDIVVANAGISGADSVFFNNVEAEEPEEPKLNIVNVNLIGVLYTIKLALHYFRRQNALNKEGPLDQVLVLQGSLAGYLDLAGAVQYIASKFGLRGIMRSLRQTEHVHNIRANYIGPWFVETKILSKPVVQHLTGRGISFATVDDAAQCLMRIVSDPSVNGRAFAIVTRDVAPRGYVDINFDDYEPDTLLGKLQGTVAGGSDHRTALKPEDQKTKTQWSESAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBW0</accession>
    <name>A0A1C1CBW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBW0"/>
    <dbReference type="STRING" id="86049.A0A1C1CBW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00413"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10026"/>
    <dbReference type="OrthoDB" id="3784821at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="511" mass="53632" checksum="46377EF421450912" modified="2016-11-02" version="1">MSLSAEGVVKKRGRPRKNAVVQELDGHVDAAVVLEDGSGGFVSSRLKTETETKTKTKMRGKGKIEAKKSAPASASASTSTSTAASSPPPPILTSTTPSSASKRKPKSLVGDAGLADVVDESHLTATRAVKIVAGSKSRGKTASKSSDVKKQDTVPVRDPTSPRRGTPKGQARVESAAFVSSSPSSSLQEEGTAPVPQPETSHLSQTSTQGISISKILQRAEAFSTHSRQLQQGILAFVDEREREREALVSPSLTQPFTNVEIQGLGSHLPPSIAIAGSLPPTVPAIDTAVEPSSAASKSTHLPPSPPQPQQPQPLPPQPLPLGTMPLPPPQFKSAAAAAAATGPAPQIRAYSSTSPLPMSTTVALAARRSQSQSRTNLPPPPPTPHPASEPRHPLPFTAPSAVPIGPRPPKLSEIPLEQRKKDPRYRKATIRYTAAIVALPFAIVTSYLLWEKYQEHQIYLQRVREARAAADADATVTTTTTANTTRAGPSLGGGSGLLERGAPPGREDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC68</accession>
    <name>A0A1C1CC68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative alpha-taxilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC68"/>
    <dbReference type="STRING" id="86049.A0A1C1CC68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00450"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10365"/>
    <dbReference type="eggNOG" id="KOG1850">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425555at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127:SF13">
        <property type="entry name" value="GH01188P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="450" mass="52003" checksum="C9F5DEF72615B009" modified="2016-11-02" version="1">MATTALSPSSQTTNGDTHDLPPPAPAAKKGKAKKDKQLSAEENAKLVQQRLSQLEQEKAGEKTQQAEIDREVKKAIRDINELVGGVEPLKGIDMIKQKYEELLAEMKKTEREHVKAKKSRDQYQKEAEKSKSENNKTATMKDKLEKLCRELTKENKKLKDDNKKLEETEKQARETINERLDQMLYDVQEAMEQKNTTHSENLHLELDELFKTRCKVLADQAEIREMHFKAILRHKDAEIAHLQAKHEIERRRADTEAARCRTLTNQVSTFSHTEAELRSQLNIYVEKFKQVEDTLNNSNELFLTFRKEMEEMSKKTKRLEKDNLNLTRKHDQTSRNILEMAEERTRDKEDLERLRKQEQQMRNIIKTMQEQGRGPPVQHDLVDEEGTESEYDEEYEDDDEDDEASYEAEEELAAEIAKPVFGPVPPPDMVATKANGQKAAANAIVNGIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC87</accession>
    <name>A0A1C1CC87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 14">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CLCR_01038</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 14">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 14"/>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC87"/>
    <dbReference type="STRING" id="86049.A0A1C1CC87"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01038"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09389"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="265"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="17">
        <location>
            <begin position="600"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="367"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="465"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="556"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="885"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="948"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1017"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1082"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1137"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="210"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="902"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="953"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1041"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1151"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1198"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1228"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1241"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1251"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1272"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT46125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1376" mass="149342" checksum="05A1B3FB0875CD57" modified="2016-11-02" version="1">MPPLVSEELDELSSVGTGTVTPSIEGPVTTASGDELGHPMNRETPKPSENGHYASEENQSNVVGSGQSRIHAAAPDDYDLGEQLQRSAQEELSEPDTDVRVAEENVAGGAESQADGEGDITMTDADAEAEPDDELPQNDPAAGDAQEPNQVAEDDEDAEGEEEAEPRKENGAVGGQETEDKESAANGEELEEEGNADSDAEDAGSDSEEGSGSAEPELESSASQSKSVSRSGSASRPVSESEAESASESGDVDEDDAPGEAEEAGSECIFCKQTHGPDGQDDELDLVCLECNNRAHLKCAQGRQAVKDDNTTHWQCPDCLKKVAQSESPKERAARSKNSAPRLVRDLLPVTRGVQRPNSHSIFAQPLISEGEDGGRALRKRKSPTQEPVPAEKRRRKATERASAVATTSAALSVDSSSTTMSTRRSSQMKISKPTARILQHRPFNKPPPHKFILAFRLDQPRIEAILSKPPRPGRRRDRKAQQKKKEPKIPAPIYQPPVPKFPALPTHNLIFPSAFTDREAELNAKPYGGILSEAEADTSRSLPQLKDRELFETARKEAEEERRRTSAAAEAEINGGVDASATPGATSATTKPNRSTVSGPPSKIKCIQFGKHVIDTFYAAPYPEEYSHESRLFICEFCLKYLPSEFVAYRHKLKCPAKHPPGDEIYRDGTVSVWEVDGRKKTEYCQCLCLMAKMFLGSKTLYYDVEPFLFYILTEYDELGYHFVGYFSKEKRPASQNNVSCILVMPIHQRKGYATFLIDFSYLLTRIERKEGSPEKPLSDMGLTAYRSYWDLTISRHLLDLQRSNTPFSTKTLMGRTGMTADDVIHSLERLYAFIKDPVTKTYAIRFDKKLYERIVDEYERKGHRKMKPELLVWTPYIMGRSDRETLEGQGPLNALAPRSDDEDEEEEQDDAETSEAVELDSQAVAPKAGKSVAGVTDLVGNDDTAVEELSPKSTAQSAMVTSRPESLVGHEESDAATVKDASLLNELGHVAPGPPPTNALDGVVSTQLAADHGEVKVSGLVNGTSSMSQEAPVDPQLQDTREPKSQNEPHEADGAEQPRQPPSPPLYGYALAFREHNIPPTRFQIDPPIPPSMLRRQNTKKRSAATAFGTPGKKTNGLGGTAADTGAVANNVAVRSSPRNTAKSGVLLGANTATASGTASSTNGTRSASPKVPGTPVRRSGRRSGLVNVVATVDGSVEDEEEEEEEEDAPAEDDDGVGAPSKADSEDGDAEDDQDDIEASSSTSSSSQGEEDDEDEEDEPQTSVAAVSDESGEDESGEEQGELDESEDDNDDDDGVDGEVDGEVDEEEDEDEEEEESADDDPNDPDAEPDEDDSEESEEDAEAEVDLPEEEDEEEDEEEEDVDDNDDDDDDGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC98</accession>
    <name>A0A1C1CC98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC98"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01261"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09381"/>
    <dbReference type="eggNOG" id="ENOG502S92C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5407781at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="336" mass="35879" checksum="2640C837A0C988CB" modified="2016-11-02" version="1">MQTANLPPNRNQTPSPRSSSISLAAAAVTNGANESRRSSLSNRGSPRLGRMPSDRRRSQVAMNISLNDPTIPSPGELSSSDSRTGFGHSYALASPPTIGGRSAIATGDPHHQRQPSLGEIHNELEQEQEAQVNRMLQMIREQQLQLEALRSSQGPNGTHSRHSSQPNSALPGNNTAVVDDDTPAAERSPSFPSIHPAVPTVPPLTRRISRGPSSASRSPALRPMLGQESSISTAVSSDWPPSPVESVSTARRNSFRDETAFYQAETANLTRENQMLRMRIRELERQISDLSASPRNTPATPSNLATSPPVQGSAVADAEASGAAGVARMTAEPEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCL3</accession>
    <name>A0A1C1CCL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCL3"/>
    <dbReference type="STRING" id="86049.A0A1C1CCL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01263"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09258"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="334" mass="36370" checksum="DF275B43A1F2FD29" modified="2016-11-02" version="1">MPGIVQFLRGQFSTPPMPQVDLTGRCILVTGANTGLGLDAARLLARLNGTTIVLACRSFAKGEKAKEAVLQSLPTGSKQPTIVALEIDLTSFSSVVAFAERCKDLPRLDAAVLNAGVDLQEFSLAEGYETTMTVNVISTFLLATLLLPTLRSSAKRYSITPHIAIVGSAVHFWANDKDITTPADGQILRTLSDPKKADMKGRYYLSKLPVMLLVKYLATVLTKSAEEDPHDKPLVIINNVAPGFCRTDLFRTHDDFVLKVMYKTIGRESEHGARTLVHGAVAGPESHGQYLSECQVKKYSAFVGSAEGDRSARRLWQELSSLYEGIKPGCTQAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCP4</accession>
    <name>A0A1C1CCP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MRM2</name>
        <name evidence="10" type="ORF">CLCR_01201</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCP4"/>
    <dbReference type="STRING" id="86049.A0A1C1CCP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01201"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09231"/>
    <dbReference type="eggNOG" id="KOG4589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="49"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT46293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="329" mass="36751" checksum="BC57C2D37791E7FB" modified="2016-11-02" version="1">MSPLAKLYLISCWSYIISFHLTLSILTLDMSASFPGDHFARAAKVQGLKSRAAFKLLQINERYRLFRPGMTVVDLGFAPGSWSQVAIDLTKPRGRVLGVDLLPVQPPKGVSTIQGDFLSPDIQAEIKAFLRDPDRGRLRRPFLLDTSSSSSSSSSSHHSESIDQATLEEEATGYLERESHVEKTLLVDEEPDADADAEHSHADKCADVVLSDMCEPWDPLDGLYKKSISNPYHRLMNTSGNAFRDHAGSMDLCRGALRFSYDTLKVGGHFVCKFYQGVEDKALERSLKAMFHKVHREKPESSRAQSKEAYFVGIKRLAKVDRDLVFAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCS6</accession>
    <name>A0A1C1CCS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch repeat-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">KEL3</name>
        <name evidence="3" type="ORF">CLCR_01102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCS6"/>
    <dbReference type="STRING" id="86049.A0A1C1CCS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01102"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09250"/>
    <dbReference type="eggNOG" id="KOG1230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4447at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="597"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="699" mass="78297" checksum="A1DCE6E0E1E054BA" modified="2016-11-02" version="1">MAPKDKKAKAAEKKAQKAAKQSKKTTKSEKKKSAKQAALNADSDDEEVDLDAVLAAYAEEQAKFLKVTEQPCRPPGPRSSSTMVASPSNRNELFIFGGEYHDGTVASFYNDLFVYLIDKGEWHQIVSGNSPLPRSGHAACRGGNTGGIYISAGEFSSPKQNQFYHYHDFWHLDIDSREWTKLEPRGKGRNPPARSGHRMTYFKNYIVLFGGFQDTSQQTKYLNDTWVYDVKENTWHEMKYTSTSQRPDPRSSFTFLPHESGAVLYGGYSRVKATTTSGGGKQGGKSSGGAVRNIVKPMVHQDTWFLRITPPPPEAASGTPPTLRWERRKQPANRPNPPRAGATMAYHKGRGVLVGGVHDVEASEEGIDSEFFNEMFVWNIDRNRFFPLALRRPKAGGPKKQAQQQSRGRDRAKADEEELLRNLAALETTGSIATEDSDITLVNEDDPEPEPDKPRKEYPVRYEMPHPRFNAQLTVQDDTLFIFGGTFEKKDVEITFSDLYAIDLGKLDGVKELFYVEPINWNVTVEESDEDMDSDEEGDDEDEDYDEDEDMGDEGDAVSIVTDTPSLAKPISTPSTERDHPPPSPVAEESDSSTLASQDNLPFPRPFESRATFFNRTSQDWQNIIIQKQSYGGAAQVAAITAEQTIKELRKKAFEMAEERWWDCREEVTRLEDELEEGGVGEIVSMAERGADAGVGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCW6</accession>
    <name>A0A1C1CCW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_01195</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCW6"/>
    <dbReference type="STRING" id="86049.A0A1C1CCW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01195"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09161"/>
    <dbReference type="eggNOG" id="KOG1324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="9">
        <location>
            <begin position="62"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="276"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT46370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="473" mass="50598" checksum="BB39F7BEE6626A90" modified="2016-11-02" version="1">MTISTPPSTTLSAPSSPTELPTSNLPPVDTSDEGLERLSPSQKRIIKTTTTVITPIFMRPKPIYIIVATSLNPPMGIGFKGKLPWPGIKADMAFFKQVTSHVPVEEEETPKSRPINAVVMGRKTWDSIPPRFRPLAGRLNVIITRGSPSDLSQRILAEIQAASEGSDAPPAWETHHLAAGSVKGRSRSRTSQQSTITVLTPPSFPPPSSKRVVFSPIMISQSLSSALSLLSSPTPISLSSATATSSPPAAPSTISIHKIFCIGGAEIYRQVLALSSHGPHTPTTPTAGGPGSETGTDTEGETQAPPAPAPAPTGSFDPFKESEHLHFDVRILQTQIRKLAAPAPVSATASSSSSSSSQPSSEHPRRNSKIPVDFECDTFFPDLLPSPGSGVKSAKWRPVLRGEGVKEWIGEAVTLPQHAGRRKESIQDEVVGETAADADADESERSDEKDGKELWFRDEKAGVECRTIGWERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD99</accession>
    <name>A0A1C1CD99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD99"/>
    <dbReference type="STRING" id="86049.A0A1C1CD99"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01041"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09101"/>
    <dbReference type="OrthoDB" id="5332281at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="695"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="758"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1262" mass="137661" checksum="B1CAC1E66C471D40" modified="2016-11-02" version="1">MISYNNEDGELPDGTTKIYKNISLQENYGCDTPAMWNSRWLSRLTLTGIGTVFVGVAVALLVLWVYNVRDDGFTLVTVNHYTWTYGPTAVLVIVVAFWRQVDFQCKAIAPWAVLYKDPGHASQTILLDYISPMQASSLWTSLKNRHFIVAAGITGFILLKVITLISTGLFILTPTRTRQSSLDLIQTSRFDGSSFNASSFVTLNDSSLVYTAYGILAAGLASPEGTSDILAYESFVPPHGSNKTGTQAVTASVKALVPAFNCESAPINMNLQPANTTDQHPADNIELLFPECQLLPDGDGIAVYALNPQRFKCPTRQLSPLMQRIDCFNQSDTATADNWQLLTLADIRYNQTLTGSDESSVVGDFVQASTWSTAVIGLTGIACRSSYSIETVKVTYDYSQSPAKVTVVRPATPSNERLDGFTDSDLGRLFTASLSAASDMFGNVLDNAYAEEYPNTIFKMMAQVASNMNGQTTGAGYEALLDEATMIAAAETVFRYVAVQIVKKNLMQESQLPLVGQAYYDQERLQMNDVSLWCMIAGFAFMTLLVAFLLLKRDRDVVPRDPGSIISAPLVLRNSKVFHTILKGSSASSMDQLLVNLRTTTFTTTTKPSQDNPAEKQFVLSANGSTNIVPRTGSDSELGWWKPLAAHRAFILATLGMPLVIVTALEILQHKSDSDSGIGAVSDVESLSSKILTRYLPALVMLLVASLFDSLDFTIAVLAPYVAMKIKTRSSKFPRLASVLGLMPFHALWTAFHHRYWGAFFAGSAALLGSVLTIVSSGLYTIDPVPSSSATQLMRTDSFTTAWGNSVLNDSGAAVLLSLSESLNLTYPRFTYEELALPRLQHAIDQAETATDDSNATISVHLPSFRASLNCTSLRASQFNLTTSYNPKVGPGATIRAAAPLPQSCHLGGSGGNLTTIEFEQSFQFPYTQNSSYVAKMLNLHVGPFDPVHELSEGELSPSTQKDNPPGCPSLGFLYGFVDVNDKSRSQATALMCYQQMEQLPVEVTLVQSDLSISLNTPPIPDESEVKVLASGPNGETAFQYRIQVHMDRELSLFNQTEYDSSGTGTSTVDRFFQGVLFGKTPIPQAWLADVSHAREVMSAIQAFYRRYMAQAISANLRVPSLASEAALLNGTLTNYNGILRVRQNAASKITLQILLGLMFACGTLAVGLSTLRKIVPHNPCTIAGVMMLWAGSKFCETDADGEDIPFLSNGAEFMSDKELMRRGVLEGWSFRIGWWQSDHGSRYGVDVVRHDTEKDPGEHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDF9</accession>
    <name>A0A1C1CDF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_02021</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BIG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDF9"/>
    <dbReference type="STRING" id="86049.A0A1C1CDF9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02021"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01258"/>
    <dbReference type="eggNOG" id="ENOG502S6TD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9985059at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037654">
        <property type="entry name" value="Big1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285:SF1">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650785" description="Protein BIG1" evidence="11">
        <location>
            <begin position="19"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="12">
        <location>
            <begin position="253"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT46529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="301" mass="32279" checksum="F17C57946EEDB293" modified="2016-11-02" version="1">MRLLGLCALALAARNAHGYLDTAPFFMFSTSELLTTTSHIQSAPLLTSDVALSLSSCPSDYYILVSQQGVSLQDYSNSKKSTPLLSKALSPSQAAESGIRSSLAVTDVLGPVDSSAWVDVLRSKCGVSTTTIISKHGGIPIDDLTTSPQLIHLNLPAPSSGKRTTDLSANDVFLASLIDLLPKQNYTVLYTTSRSADGMVVTQGREALDYDMESQLQESLHLDLKRDLGVHASANRSGNNQTIIDGPLFDKYQFFTPGIFMGFLVGFLLLSMLYVAISAVASLQVTYAAFDKEQGQLAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDH8</accession>
    <name>A0A1C1CDH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDH8"/>
    <dbReference type="STRING" id="86049.A0A1C1CDH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02069"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01310"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="282" mass="29756" checksum="C2E7C27D35C9DF64" modified="2016-11-02" version="1">MAPSGLAILLGAGPTTGAGIARVLARPSQGNLAVALLSRSGDAALADRLSQEAGGGVLKAFQSDTTETSLNDAFREVRTWAASLVDGGGLKLQLAIWSIKHSHKTAFEDETSSRFGDSLQVYVTGAMVFSQLALKWFLDQYPDDNTSVSGAGDPGSGEEHEMVKKGTLIFTGTLGALRTNPGYAAYGAGRAGVRMLAQSLAREYSARGVHVVHAIANGGIVDADASSAADGDDAATKEKRAKVLLGEKIRAESVGRLYLDCMRQSCDLWVHELDMRPAREKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDK8</accession>
    <name>A0A1C1CDK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDK8"/>
    <dbReference type="STRING" id="86049.A0A1C1CDK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02127"/>
    <dbReference type="eggNOG" id="ENOG502TFGU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650737" evidence="1">
        <location>
            <begin position="18"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="196" mass="18229" checksum="E93BEA05A75666AC" modified="2016-11-02" version="1">MHFSKSIVLAFAASVAAQDVSSIVSAATSLASSFASDATSAFGSATSGANSAISSAESLASSFGTSVPSDVNSLISSVESRVSSISASAASDVASLSSVAATATGSAQSSISSQISSILASASSAENSVVNSATSAASSYLTSASGAASSAASSASSAASGASASATSDAGNGANGYTVPATGVLGSLFLGMVAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDP2</accession>
    <name>A0A1C1CDP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione-dependent formaldehyde-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_02145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDP2"/>
    <dbReference type="STRING" id="86049.A0A1C1CDP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02145"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01311"/>
    <dbReference type="eggNOG" id="ENOG502SWXF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="156" mass="17835" checksum="1F62E28CB40FB483" modified="2016-11-02" version="1">MSSTEQEDIKRTFHGSCHCKFITYTVALPQSLLDNPRGGRCNCTICLKQGFTEIRLPRSDFHLISPSSLSECKDYRMNPEHNVHKYFCGTCGIHVAAEGSFEWKGETVEFFQINVVTLEQPQEGLDLSQWKMCYSDGRHNNFENIRDDVPWPGGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEU5</accession>
    <name>A0A1C1CEU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative actin-related protein RO7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEU5"/>
    <dbReference type="STRING" id="86049.A0A1C1CEU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02388"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02444"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="534" mass="58875" checksum="5A555E58DC0D8D47" modified="2016-11-02" version="1">MASTVASAIRPGLREGTSRQQSGSPHTPTGRFVSSAQSSPGSYSFRAEEDPIIIELDPRGLSAGFQGESGPQCYIPFSPQNSRRVGDYRVFLPGFRRRREDIAVKSREYELWRNDLIDVDLGLLEDKLERVVREAYNKHLLVDAGAARLVLVLPSLVPHPVLSTILTLLFERWKCASITLFPAPTMIVAGAGLRSGLVVDVGWEETVITAIYEYREVHVRRSIQAMKALTVKIGALLDAIRKDQDGTTRDTLVLDFDFVEEFISRAGLCHALLPVRGESLAAKTEAMNLEDRSSVGPAENATASLMIDWPTDTSSQSITIPLQPLHQACLNTLITITPRSEEYPDDHEQSISQLLYRSLLALSADVRSICMSRIIFTGRGANVAGLAQHILDTTDSIIQEHGWTPVRGEHFKSKRSGLAELAQARAVPADVKHDMTLPGTDDFVEERLFKQRSKNAFPPVPAVLRQVNSVGPWAGASLIASLKAKSFVEIERERFLSHGLAGAHRDFDPSSLLQQRNTATKGHERTSWTLAGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF30</accession>
    <name>A0A1C1CF30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02536"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02339"/>
    <dbReference type="OrthoDB" id="10496763at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="332" mass="36585" checksum="EAB917E18AFEB53B" modified="2016-11-02" version="1">MATIIGGAAISSCSRLEVLPEEILSHVLSFVPFSKKNWLSVSLTSPRLRDVATKSVTGIAKQQTPLLFSLFHQPYIDAETVGYMVEVHSALSHFAEYATVAVGPGSDHWGRYQSILLGAAIITRILYANRLLRTTKGNHAAEAFLDRAIASCLGESAMLLIRYTALCSFHCFMRARASAQETCNESKRAVAERFDQDTFLRFEASLLMTGLGFGEQVFKHVHEWSSRMISGGTAPVRAFAVGRQRHSWRKSALEEEVQTWWRVVRSSPEGRIAIEAASQRNTQAKPADVNDAICTLFHGSGQPPAALRIADLQEIGRKLSFESDEALGLGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF84</accession>
    <name>A0A1C1CF84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_02383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF84"/>
    <dbReference type="STRING" id="86049.A0A1C1CF84"/>
    <dbReference type="ESTHER" id="9euro-v9dfn4">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02383"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02239"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008448723" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="25"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT47195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="525" mass="56662" checksum="923092238F76281B" modified="2016-11-02" version="1">MKSLLPVALNLLVAFSEAACISSQSLSVTANTGVFTGLLNPTYASVREFRNVPFAQPPVGELRWLPPQKLPASSKRYDATQYPRSCPQFVSRVKSVWSDQIPEWLIFDGGESTSAGLYAYGTSEDCLSLAIWTPANATAASKLPVIMFMTGGGMVTGGVNIPVQIPAEWVSRSQSHIVVTINYRLNIMGFPNAAGLETQNLGLRDQRAALEWVRANIAAFGGDPTALTLWGQSAGSRSTDYYNFAYYDDPIARGFFMQSGTALSSRAGTDFQGTNFTFVARNLGCNFPNNKTAELQCMRQVPVSDIEKFVGQYQDNSTTTNPHQAPIAFTPIADEDVVFSNYTARYLAGQVAKVPAILSNTANEYSSLAPYPLNNLTDGPNPQAVMAGTLNTVCGISNSSLYRNALNIPTYRYVYGGNFSNINPLWWMGAYHAADLPMMFGTYGIRAGEPSQLETETSAAMQDYVLAFVKDPTNGPASVGWVPYDYRDGGGQMALFGADGLAVQQVNGTTVEGVCYGTGAYDSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFB1</accession>
    <name>A0A1C1CFB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_02474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02474"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02268"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT47162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="409" mass="45617" checksum="59F892C0DC428A45" modified="2016-11-02" version="1">MFDGATTKTAIVHRDEHGSAHAKLAEDSDDVHVQANELLAQQEPQLLISVSPSFGGAPNELRNLDYWLDQTGPTLANYGPNFGFWCGLIPMWAWRSDIIRNLLVATTLIDEQLGLYRTATLTDLSPTAIWHYHAAIRSMATANQPDKFCLTLASMLAWVFETLQKNYSAAKIHVRAASRLLSELGAPSNKLDKSTLDLITQLNSVLQLSASYTKAICEDNFDLPRNLTEEPIVARAADLAIPPVESLMHARDLLLDSMSRYLASDKTAHSARLQRLYIKSWHMAMRRYCSCSTRESHVYKKTVQLCFNLGMAFLPESVAGTFSYQATPNAVRHLLEAYERLVVEKQTRGSEPDNDSIDKTIVMALELILDQVHHVHLRARAALLLQKLTAHHEKVGIHQGRPGVSLISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGG2</accession>
    <name>A0A1C1CGG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Beta-galactosidase</fullName>
            <ecNumber evidence="4 13">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">lacA</name>
        <name evidence="17" type="ORF">CLCR_03279</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="4 13"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGG2"/>
    <dbReference type="STRING" id="86049.A0A1C1CGG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03279"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01772"/>
    <dbReference type="eggNOG" id="KOG0496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.20.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000065">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000088">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650789" description="Beta-galactosidase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="16">
        <location>
            <begin position="396"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT47613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1011" mass="110544" checksum="6411E7B669F7BA28" modified="2016-11-02" version="1">MRVSTLWTLILWAAQAAALAVPIQDVGRLRIIEHPNPEKRQLLQDIVTWDDTSLFIRGERVMIFSGEFHPFRLPVPALWVDIFQKVKALGFNCVSYYLDWALLEGKPGNFSAEGVLALEPFYDAATAAGVYLIARPGPYINAEASGGGFPGWLARLRGRLRTTDPDYIAATQNYIRNVASSIATAQITNGGPVILYQPENEYTGACCGVEFPNGQYMQDVIDQAHSAGVVVPMISNDASASGHNAPGTGVGQVDIYGHDNYPLGFDCSHPTVWPDAALPTTYWQTHLNNSPSTPYSINEFQGGSFDPWGGPGFAKCEILVNYEFVRVFYKNVLASAVKIFNLYMIFGGTNWGGLGHPGGYTSYDYAAAISENRQVDRQKYSEIKLLANFVKASPAYLTATPQELNTTSVFTDTSDLKVTSLTSDGSATTFYIVRHYNCSSLSSTSYRLLLPTSIGNLTIPQLGGSLTLGGRDSKVHAADYDLGGTNLLYSTAEIFTWKIFGDRTVLIVYGDEGEHHELAVTTLSAPSVIEGEPSTITTNQTGSTAIIAWDTSPIRRVVQVGQCEIYLLDKSSAYDYWVPEVSGSGASSPFTTTESINASIIVKAGYLVRQVYLQSSELHLTVDVNDTTVIEVIGVPESSKALYINGEPVQYHMNARGDWSTCITYQEPTITIPALESLEWKFADSLPEIQASYDDSSWTAANLAYSNNTVRNLTTPTSLYASDYGYHSGSLIYRGHFTAKDTTANLSINTQGGWAFGHSIWLDQSFVGSYAGVSTQNNTNATYTLSGLRLGANHNITVLIDHMGMEESGVVGTDKMKTPRGILDYALAGYDKSAVTWRLTGNLGGEDYLDRRRGPLNEGAMYAERQGWHLPSPPSQSWENRSPMDGIPEPGVGFFSTSFDLNIPTGWDFPMSFVFGNDTKPPVPYRAQLFVNGFQFGKYVNHIGPQTRYPVPQGILNYNGTNWLALTLWAHESGGAGLGDFELVYDRPIATALKNIAFVGSMAYAPRPEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGJ4</accession>
    <name>A0A1C1CGJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_03678</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGJ4"/>
    <dbReference type="STRING" id="86049.A0A1C1CGJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03678"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13934">
        <property type="entry name" value="RNase_H_Dikarya_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="53"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="221" mass="25568" checksum="38622E7FA9271B17" modified="2016-11-02" version="1">MEMERPRRNFNPRKTRRYGRQTFDPDYLVKYSPKWKYCRLYNFPFPGAHWQPRMRTIVISVDGGSRGNNRSDPKSRAAYAVYFGPNCHRNAHGLLPPNVPQTSSRAELEGVHKALELVQAMKRTGEIDGWREVIIKLDSDYVAKSLCDYIWTWERNGFMTRKGTPVEHGELIREMHATITQMEKEGAVRFWRVGREWNKEADALVNQALDDAADSGYGSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGT8</accession>
    <name>A0A1C1CGT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03710"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="115" mass="12835" checksum="D029687262EE7538" modified="2016-11-02" version="1">MATPLYQVCNGSKPSSQLGPRSYPQIPIWIPQANFVTTSPRRVSCRERHVLSSPSSKEAHERVEELKSSGIPLYPRYRHSPQKRSFESIRAEVDKGNTGDGLDTLSEVAEGKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGY5</accession>
    <name>A0A1C1CGY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L20-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPL20B</name>
        <name evidence="6" type="ORF">CLCR_03663</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGY5"/>
    <dbReference type="STRING" id="86049.A0A1C1CGY5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03663"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04613"/>
    <dbReference type="eggNOG" id="KOG0829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="40"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT47727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="208" mass="24141" checksum="4BAC04368DD42CFC" modified="2016-11-02" version="1">MGEGGDRSMAADVREQPTNGTLAAQKKKSSSILTSGFRRLQEYQVIGRSLPTDANPTPKLYRMRIFAPNTVVAKSRFWYFLSKLRKLKKSTGEVVSLNVIHEKRPLKVKNFGIWIRYDSRSGTHNMYKEYREMSRTDAVQALYQDMAARHRARFRSIHILKVVEIQNANDVKRPYIKQLITRNLKFPLPHRNSKSKKLFTPKRPSTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH67</accession>
    <name>A0A1C1CH67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_03243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH67"/>
    <dbReference type="STRING" id="86049.A0A1C1CH67"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03243"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04554"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04555"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4152109at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1412"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1460"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="724"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1494"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="732"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1494"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1522"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1545"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1567"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1578"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1592"/>
            <end position="1602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT47791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1649" mass="184343" checksum="58392FDCF11EF0CD" modified="2016-11-02" version="1">MTQQLMISYSSLSEGWRKEIRSCVNSVRKLQQMRHAQNYAAKGRRLSANLGQHRDEEEDTELHWAARLGNDTVLNLLLAARGDSDYLEAQNKAKETALYDGIRAQSLEVVQRLLQKGAKVMISNIASFSPLHLAAKRKSAAIARLVWDEITDKEDQQRSLTAFTDEGMTVLHHAARDGHKDTVELLLKAGAEPNVISHRGKRPLHSAASRGKTKIMDLLWRAGAATNTTTNNGYTVLHCAAEKGHYEAIYIMLNTWTLAQGHKALGSRKAGEEAPSTDAGDSLTAKNLDQVIPQSQQPRKSRGMPLTQEVLARTLADGSTALHLAVSSSKKKGESSKVVGLFLDKLDEGVVAAQTKQGETIFHLIARGRRDDLLEVLTKVPQIGKMLEVQSKDGSTALHRAIEDGSSKLQERLINWISDAATCSQNNDGETALHLAARKKRPYILKKLLLKMKPSAIATRNHHGETALHIAAAIGEADVTARLLAQMTPDDIALLNDKGENAFAKAALTPNPNPTIIELMVKYEADVSAQYETTWAPMDQQARNSVSSTLTEVLDKISWTEYSSHTSWQMIVRWASRNGDIKTVKRILDAVPVNFVEQIDRQEQGKADRRGSTTVKDEQMPSTPKEIALFWAALGGHEDIVKLLLNHPSLDAYYRRSTRANDRCLRATRAAARNGHFSIVKVLLQHMQSTDGMGRQDWTPLDWAIATGDPDIVRFMLIKGAESLPSAPHPTKSPEVDRLLRDPQPRPRWYSRENPLSVWSSRPKLKLTPFEDACKRFSVSLVDFYHHDGGIYPLEMNGRSVFDVIYDPDLGPNKIMECARESVGDHPAMQNHHRFRWIHLPANNWKWVRDLMKRICYHTKQENECWSLQKFVEANRREHLGRPQSRFMFTDVRIENTRAGKSRSETNGRSMALLNAGTGSDEFCHLLGRRMAIYMPFITVETVQEQQLLQHACQEAIANGLTSKNIHALENLQEIANAQGDAVPFLTEDSHGDLKALYEAIAASNWNLGSRTAKVLECLVKAFKRAPNSGDWTLEQTSGYEFSGLDLKNAIEEQKKISGPYHPNDSAQKVLLRHYLRAGEPNALHIRRTLDQYYYPALPEDRTKCRDGDQVVYRFQYRELRKAKKDLGSDTLRNLRICTVDQLWLWVIDEKTLITCFPQRWSQSNPQETDTKNGPPDVLEFVRDRIHNDVNLELNSVYHLATFITTLCTAFVDECTAEPSASSETFLQIFANAIGIESDDESNHFEEFKNSVKKLEKSPLGKDDAKVQEGSLDSSLKISKEVDCLNEVKDIRDELKIISNIFSHQKFVLEELRKEASRESSTASRDAECLHSNFVSELPEYSDLETRYDQVKKMEDDAKAVYVRLNHLLDLKQKHANFLEAGLARGQAEEMAKQTSKLNQQAIESGKEAKTILFLTFVTIVFAPMSFLTSLYALNVSAFSGGYVDGDSSTYSSKWLFRRVFGYSTAVAVPLILLALLVGGFLEKTVVGFKKRWSNTPIDPSSETGNATAQAPSTPNSPPPSSSQSKAATPPSRSWNLPKPKRSTQRNARGTPTAAESNRRPTGLGIFNSTLADQMQRQAREQPTHGDRSTAGMGSTKSSPTVIGTPKTAENACNDIEHGTARVKEGVFSRVFWRRKSRKSSTPPPPGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHP7</accession>
    <name>A0A1C1CHP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylethanolamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHP7"/>
    <dbReference type="STRING" id="86049.A0A1C1CHP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04285"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08201"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF148">
        <property type="entry name" value="CARBOXYPEPTIDASE Y INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650860" evidence="1">
        <location>
            <begin position="20"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="255" mass="28870" checksum="DFB00B6F93218607" modified="2016-11-02" version="1">MRLTTSISIALALLDRTAPLPVGEEQRPLALPDEALSRPVPYAHYSVQSTIRDVLVEHEIICDVLDDFEPSYYLDINYPKSHETVLLGNDLPVDAVSSRPVFTFHSIDNSYYPTRRRSKKADPCTTRTERKKSTFTLILTDPDAKSRDNPKMSEMCHWILTNLTTPIELPHDLQEPLKAKPGEIEEYLPPGPPPKTGAHRYVFVLLEGDATNLKPPADRKHWGYGKPRHGVRDWAKENGLTVVGANFFFAQNEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIK3</accession>
    <name>A0A1C1CIK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="3 9">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_04277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="9">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPK1 type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="3 9"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIK3"/>
    <dbReference type="STRING" id="86049.A0A1C1CIK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04277"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08408"/>
    <dbReference type="eggNOG" id="ENOG502S7VH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT48261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="300" mass="33881" checksum="517E37A8FB452081" modified="2016-11-02" version="1">MRLRKDLSFTKPAQEVMLDFNTAILPLFGDEYRALLMEQALYQLPEEMVQKTNDELREMDQVDESAVSAEGLRAVGRKVRHAHRRHVYLPSYHVEQYGILMQNLQGPGIDWLVEFKPKWLVQSPSAPSDARNCRTCALNALRRKDGKHKGRGDSGFCPFDLLVGPEEGDVLTRALKNIWPLDEGIGKFVAEFTIKVQPALRHLQRLEQEHGSVGLDDFQKPAGKDFGVAMALRDCSVFLALRRSTTEGVDVVDVKFADLDLKTTEGGKVQKWAAMEQELLDGGWYYKSEGSDCSLSRAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIZ3</accession>
    <name>A0A1C1CIZ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FDH1</name>
        <name evidence="15" type="ORF">CLCR_04098</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIZ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CIZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04098"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08602"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033833">
        <property type="term" value="F:hydroxymethylfurfural reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080007">
        <property type="term" value="F:S-nitrosoglutathione reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000947">
        <property type="term" value="P:amino acid catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033859">
        <property type="term" value="P:furaldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="207"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT48478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="382" mass="40619" checksum="7D3ED380B4AA7DC9" modified="2016-11-02" version="1">MPADTAGKTITCKAAVAWEAGKDLSIEDVEVAPPKAHEVRIQIYYTGVCHTDAYTLSGKDPEGAFPIILGHEGAGIVESVGEGVTNVKPGDNVVALYTPECKECKFCVSGKTNLCGKIRATQGRGVMPDGTSRFKCKGQDLLHFMGTSTFSQYTVVADISVVAITDKAPMDRTCLLGCGITTGYGAAVITADVEKGSNIAVFGAGCVGLSVIQGAVKNGAGKIIVVDVNDKKKEWAEKFGGTDFVNPTKLNGQTIQEKLVEMTDGGCDYTFDCTGNVQVMRSALEACHKGWGQSIIIGVAPAGAEISTRPFQLVTGRVWRGCAFGGVKGRTQLPGLVQDYLDGKLKVDEFITHRQPLDKINEAFHDMHAGDCIRCVVNMREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ25</accession>
    <name>A0A1C1CJ25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ25"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11298"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08567"/>
    <dbReference type="eggNOG" id="ENOG502SVIN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3913483at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="12934" checksum="D01DFF411390FFBE" modified="2016-11-02" version="1">MSDQTYHVTGEDVRKIESKESKFHGGQVPKDSDTAALKQLLSEQENKQDTIDRVKANLPLPDQPVGGASADLQSADGRTVNVGSGGVNVKMGTHSSEGLREPATADSSVRVDGEEFKKATAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ53</accession>
    <name>A0A1C1CJ53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_04148</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ53"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ53"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04148"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10284"/>
    <dbReference type="eggNOG" id="ENOG502RYN6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF149">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="32"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT48564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="383" mass="42895" checksum="B3D04A702A53A2B2" modified="2016-11-02" version="1">MSTNPNPGFVPESWSLYGVGALFVVLRLVGKVKRVGFRQLEVDDALIAFGFGWYTLLVVAFNEMLKGPGSNLMTPEEEAALTPEIIDGRIRGSKWVFVSEHAELLTIWSMKAAMLVLYAKIIDKARQRKLLWGVVIWVCCAFLGDEIALFTICRPLSQYWAVPPNNAQCSTYQYYQIVNAVFNISTDILIMLMGIPPVLSARLSIQQKLILGIIFGMGGFVIVAAILRAIYCLVPSLISYVYMNWYFREASVAVYVTTLPGIWVFLKEVFPIIQRLTSRTPTRPTNSQTADHQKQMASWRQPSRNNHSQFDSKNDLDFDLDTYPISKSMVTTADHELGNQPVTSSDNGQGDGDSANSVRYEAVVNGIRCDKSFTVESIPRTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJE3</accession>
    <name>A0A1C1CJE3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJE3"/>
    <dbReference type="STRING" id="86049.A0A1C1CJE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04025"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10264"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="496" mass="53908" checksum="0C40962D2E7D00AB" modified="2016-11-02" version="1">MNSQKTTSSPTKFAWIGQALLIPGLLLTSIVAFTLFGLKLNGWRGSEGFAESITNERTTVAIAIQIISHVLGLIQVQALCTVLKSSLTSIHLFAYILPQRSIYTQSVILIAMAPVRAADNATNLSSLWEGDTSTSTSGSGSLGQWLTADGLFSFDPSALRSVILNSASDASTTNSSGHLHQKLDMTGCLYLNRSYGVGAATGLVDIVATGSSSPPHWISYSEAGFHSEVSCIYNASSAYRIDKLDTPSGWTLNIYQAAGFYPTGPSTGGWVYVGYSPMDIFSWGATYSNKTRRSYLSRTTAATAHPKTRGRFSQFKNIQCQIDFQAKNISILVNHTNNIISVTPGAEVPWPSYADAVIDKSHKLAVGLLVRRQLLRLLVPRPHAPSQRQSAAERHGRRLQLLLLHHHHHYTTLRRVDDYVTSCVADYVTSCVDDVLVALCSARLVAANATRPVEARIALPARTAGRDKSTSAASLPWNMLVCLLYAAEGLRTRFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJH9</accession>
    <name>A0A1C1CJH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C6 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJH9"/>
    <dbReference type="STRING" id="86049.A0A1C1CJH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04787"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03225"/>
    <dbReference type="eggNOG" id="ENOG502RXEV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="59794" checksum="6634285F18C58FE9" modified="2016-11-02" version="1">MTLADYSFQCDRLGRVCVYQDGSSPTHSSSPGKSQPSIDHGLPSTESIAAPHDAMHVFDNFPVSPFGTYGSWGQPPLSVEPVGTLDGSPGFAPSNVDPLLLASSYVDPMLHTVASADSNTNQQPINIAASVPATAANVNKFPYFLEKLEPPFISHFDRYNWIRMRQYLADLGSRDSMVASAIIAVQALYEAEENGWDTTNAIALYYASKASHATLLEELDPGFEPTIMAAFLLLCFEIVAQQETVPVTMKPEGAFVDKLEQWAKLRPWPPVACRVETWLKLLHVKALHLGGRGLMCAKVSRLLSYDSGPTPSLIFLDQHPSPPSILYDSLSSQLFEFYMQTQKIGASLCGLNRHHRSRGSLMDETEVDHVAQNIRKQLQSLYQQRPSVLQLRSEELRSVIPAPFANSLATLIDLCNAAYHIEIVDLGRAHGQWLTPTPEAQEAMQHVRHIVDENFTQNSGAVSPGFMWPIFFYALEADEEGGKWAVRMLQQIRRPTCHSDFFALFLEAVLDQQRQKGERVDCRYLCIEKFGIPPPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJQ4</accession>
    <name>A0A1C1CJQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04954"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03147"/>
    <dbReference type="OrthoDB" id="4148063at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="352" mass="40500" checksum="0EA9CD32CF347E65" modified="2016-11-02" version="1">MDRGAAMPSGSMADTPQTPPLLTVPTEIRLRIWEFVFDRLHYFGGVSHDDCRNEIPPRGYIEEEPKEIVDQDLDDDVDLPPKPLPPCSCNDRQLLPLYLCRQTYGEMKEAFKRGRITAEYTANPVIELKPTFFGRIHTLILDETVFPILKFSPGVLDRVDYDDIEWVFPGLKRVVMPEGLGSGLGLRFPSSIPMHIYCCLRNREGPNGMPTADMTGIVRSDLSGHGFNERFHATELVVRNAGIEVSSTYRYMIWASQILSWPFNTAENDIYKGDFSGEITWDKTSMRISDLPDLRDEWWFDEWLIDDGHEPLHQKIDWTSELGGWDMMNLFDRTGDERTIWVETHELSNSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK08</accession>
    <name>A0A1C1CK08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alpha beta-hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK08"/>
    <dbReference type="STRING" id="86049.A0A1C1CK08"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05056"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03054"/>
    <dbReference type="eggNOG" id="ENOG502SQ3F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="45"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="307" mass="32643" checksum="92191484D99125A4" modified="2016-11-02" version="1">MSPSPLTAGKHTATLNGLRIHYTILADSPDLPPILVHPPPWGVGAELYINTFARLASKYTVIIPSPRGNDDSDRPASPTEMSSRHVVSDLEALREHLGLDAFPALIGHSSGGTVALGYAIAHPTRVRRLVLLNSDLLGFPRQDVSFFHEVLGHFAASPPTTDETFRAFMLRIMPLYFAHPERRGGGGGGGGGPVTLADLWTGNPSLWAYGAYYAADSASPPGEGAPGDGNAKWKQVDELGNVAAATLVLTGREDRVTGPEVSARIAAGVRQSRLVVVEACGHMSWVERPSEVWGVVDEFLAQEGVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKU5</accession>
    <name>A0A1C1CKU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_04552</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04552"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02869"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="603"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="652"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="42"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="216"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="394"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="822"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="931"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="933"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT49052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="959" mass="108368" checksum="3E35B610FCEADEF7" modified="2016-11-02" version="1">MSVAQALYPRQTSFAPDANLSPGEQVLQLIANPFQTSLQTGAFWASLATSLGISAGLALLFCLIRPRNNVVYAPRLKNADKDHAPPPIGKGLFSWVAPVRHASEPFLMEKIGVDAVIFLRVTRMLRNMFLVLGLIGIAVMIPINITQGNKAITHGLDAFAIMTPLFIFGGGLWAQVVMAWLMDLVVIYFLWFNYRRILKLRRAYLESPDYQKSLHARTLLLRDIPDQLRNNEGIAHVIDEVNPTGALPRTTVGRNVKVLPELIEEHEKAVRELESVLAKYLKNPDKLPPNRPMIKAPSKYRGQTSGGKVDAIEYLTDRIRALELEIYDVRDRVDNRDAMSYGFASWDHISQAHTVAFQARSKRPRGTKIQLAPRPNDLIWDNLALSRASRKTKRIMNGVWIAVLTIIWTPINAGIAVFLSNLSNLALVWPAFKPQLEAHHTGWSIVQGIAAPAITSLFYLLLPSIFRRLQVRAGDVTKTERERHVLRNLYSFFTLNNLVVFSIFSAVWQYVTIVIQYNENNNDLWTSLRQGQFFLVITTTLCQISPFWVTWLLQRNLGAATDLAQLWQLTYVWFARTFMSPTPRQNIEWTAPPAFDYASYYNYFLFYATVALCYATLQPIVLVVTALYFTIDTFLKKYLLMYVFVTKTESGGQFWVTIFNRMIFATMLSNVVIAIVVKARGEWTLVAAIAPLLVILVAFKWYCMKTFDLDLKYYARGGSQDSERMAAEAKVGKAEKISSRFGHPALYQPLMTPMVHAKARHVLAEIYHGRLNSEAGQSMTFSDIAMQPMNETSKPPQNVPFEFVPEAQQDFQFYKNREDFRSEAGDDMLSESSAQTPAPSIAKNEFGSAPSTRDSSPAPAIPRLAVHRKQFDQSNVPAQFRVAPVAPAAGTLAPRHGPYTDPYDDRANLLGSAGDIRTPNGEFMAMDQFRTPMESRDGSEYHDNTPRDELGYDYFRNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKY3</accession>
    <name>A0A1C1CKY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_04585</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKY3"/>
    <dbReference type="STRING" id="86049.A0A1C1CKY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04585"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02760"/>
    <dbReference type="eggNOG" id="KOG3655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11281">
        <property type="entry name" value="ADF_drebrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11961">
        <property type="entry name" value="SH3_Abp1_fungi_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000045">
        <property type="entry name" value="Actin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035718">
        <property type="entry name" value="Abp1_fungi_SH3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="ADF-H" evidence="12">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="674"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="761"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="161"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="318"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="734"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="458"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="740"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT49170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="819" mass="85192" checksum="96E6D3E2275AADD7" modified="2016-11-02" version="1">MASLNTSTNGPSISKSYQSVVNAPPPSGPAAASPTYGQWAVFSVSAPLANAFQDSSNKESVLKVQSTGEGELVDLIDEFSDGRIQFAFVKVKDSNTGLPKCALIAWCGEGVPERTKGYFTSHLTTVAKLLHGYHVQITARSDRDLTPDGIIQKVADASGSKYSSSTSAAAAPPPVAATKPTVASKPVFTPTQSSGISSGYNPVSRNLPQKSSNVDEDGWGVDAPPVTRTQLEKVAPAYQPTRVDMRELTSQKPTSSTFSSSEADDRPGVVKGAYQPVGKVDIAAIRRQAQESGTLKDDRPAIVKGAYEPIGKVDIAAIRAKAQKPDDSPGFSRPLPVSSPSTGPSEEPDTPSRSLAERSAAFSQGPERLTSLPKPKVANKFGGGSTFTGTKAPVPGGFEAKPLATAAPVGTASRTFADQGGKTPAQIWAEKKARERGLSASGEPPASPTAYDGRPPLASQTSGDAGWKSSYTGKSWAPVQTSHTGRSSIGQQSTGEGTGQAQEDETPSSPAGGISSIRDRFSGAPPMGAPATFDRAPPQAPEPDTSNKPNRGIPIPGLPVSQPREESAPALPPPPAQPRSPTPDEEEEPPSPIRVAVPVSASAHVADAHEEQLSPPPTMPTTSLARAIPPPARQEEDDEPARGPDPGRAAAVTAAATTLGAAAVESAPNPAAAGGGERARAEYDYEAAEDNEVSLREGELVTDVQRIDPDWWLVKNEAGQTGLVPSNYLTVLDDDETAAPAPPPAPAAAEPTPPAPAAAQAKGATATALYDYEAAEDNELSFPENAIISNVTFPDEDWWHGEYNGQSGLFPANYTKIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLB0</accession>
    <name>A0A1C1CLB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLB0"/>
    <dbReference type="STRING" id="86049.A0A1C1CLB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04595"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02671"/>
    <dbReference type="eggNOG" id="ENOG502RYFW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4114825at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF1">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="2">
        <location>
            <begin position="173"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="795" mass="89310" checksum="CC30BE642EB04341" modified="2016-11-02" version="1">MRRLQGRVTWDDIRSAGLRRWDGRGRVTTDWINIFHEPELCWPTGDCLVYLREPGQSSRGPAFRVHTDFLRVRGFESLVDRCIVRNSIHATVQCALPNCAGCDPHETIQELYIPAPHGASLEDVFHHHITTRNFFAWLYNRPLAGRTLGTALASLKARLDEYRPDDSSQNTLEVLSYAEHQRYLDFRECVDHALAALYLAEKLKVEDLWVDAFAHCVGMSHRGLRSSIEYAVLSAKAKTLVNRARLEMDVRLNNVNKSVVSFFENEVSCSFLGLPQPAREHLDKFRTFLKSVYSEQYGSWPPDNFEEEVVQQEIYSTLFSDFLNLYQHLVDTESSADMVENDISKTGGVCTLQNIQAFDKEHSYTPLAQPLPKLPEPFEPSSTRPKLQRRLSWNPKQRRKALRKTQQAHDKSALVAASNRDVLLMDCPLVRRYSDFEEMTVDDDLSCLSAIEGRKVRWILICAVLQTFHSIAQPPKEVRNISNLTYSLCCRPPAQKPWQEQQLPEVRTLDKRDSQLVPDNSYSHTNLSSPSLGESLTRGRSAKARRRTLPANLSASLLASLPTKTPPGSRSTSLRRLVSRRSKLGVDEVAPKRPSFCEIFVEGYGNGLNEIARDGAKNTPAELTAEPETMENTIKEDPKEPQELQGDIVHEMDANDTDNHPPPPSSDDSPTSPPSMSREASNSSISETSSSTREEGDIDPVTPAGNAVLSLVEILKSTGMSPAPSSPRAHTAGPVAKPRPVSLIVESTRPEINIVDMDRYDPDLESPYVHFNTQTWDMILEPRPMTAPSPRPIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLH7</accession>
    <name>A0A1C1CLH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ-related protein SCJ1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SCJ1</name>
        <name evidence="10" type="ORF">CLCR_04921</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLH7"/>
    <dbReference type="STRING" id="86049.A0A1C1CLH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04921"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03279"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650890" evidence="7">
        <location>
            <begin position="23"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="148"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="148"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT49360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="420" mass="47330" checksum="AE90E1803983D410" modified="2016-11-02" version="1">MLLLQLLAHLLPIFAFLTCCLAAEDLYKVLGLDKSASDRDLKTAYRKLSKKYHPDKATGDEKKFLEVTEAYEALSDTTTRKIYDQYGHEGLENHKRGGGGGGHAHDPFDLFSRFFGGSGHFGRANSGVRRGPDMEVRLQVPLRDFYTGRETEFTIEKQQICEECEGSGSADGQVETCHKCHGHGIIMQRFQLAPGIFQQQQSPCDQCGGHGKIIKHKCKVCGGNKVVRGPTTLTAVIDKGIPKNHRLVFESEADEHPDHVAGNLYAYVTELEPSMSENEQERTDGTFFRRKDDDLYWKEVLSLREAWMGDWTRNLTHLDGHVVQLSRMRGEVVQPGQTETVQGEGMPIYHGGHVHEHDHDGPEFGNLYVQYVVVLPDQMESGMEKDFHAVWEKWRKKKGVDLLADSGRPVKPDVPTKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM35</accession>
    <name>A0A1C1CM35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">RPB2</name>
        <name evidence="22" type="ORF">CLCR_06567</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM35"/>
    <dbReference type="STRING" id="86049.A0A1C1CM35"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06567"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09817"/>
    <dbReference type="eggNOG" id="KOG0214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14 22" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="47"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="295"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="510"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="609"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="713"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="789"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1163"/>
            <end position="1255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OCT49557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1265" mass="143239" checksum="DBDF5007298F0D59" modified="2016-11-02" version="1">MADYDEKYELNGYGENGAYDEVDVGQDDITSEDCWKVISSFFEIKKLASMQIDSFNHFMRAGLQDLINEKGGVTLDHAQNVDDDDPNPVVIKRHEVKFGKVSLSKPNVTEVEGTTADCMPHEARMRSLTYASPVFVRMSRRTWYAKEKPWQEDSRYEVVQSQRDDGSQLYWRQSDDPDDNEAEKDVFLGKVPIMVRSMTCHLVSEQFQGERDLFAWGECPYDQGGYFIINGSEKVLIAQERSAGNIVQVFQKAAPSPFTHLAEIRSVIDKGARMMSQCTVKLFRRVDGPDGTKIDNPIRVQLPYVKQDIPLVIVFRALDIVSDADILEKIVFDQSDKEMMDMLMGSLQEGQAIQGADLARDFIARRGTVPTLKSHERQKHAIDILTKEFLPHIGQTADATARKAFFLGYMINRLLKCALGRAEPDDRDHLGKKRLDLAGPLMTNLFRLQLDKATKDFYRYMTKRVEAGQQINMTAGFKNQMITTGLKYSLATGNWGDQKKLDKAKAGVSQVLSRYTFASTLSHLRRTNAPIGREGKIAKPRQLHNTHWGYVCPAETPEGQACGLVKNLSLMSMVTNAYETKPLTDYIMSLNVEALEDWEPRLNPQATKVFVDGVWFAVVLRDPKRLVDDLRKLRRKGTFDQQVSLVWDIREKEFRVSGDSGRIIRPLFIVETDRGSPNRGNLVLNKEHIQRLDNTAILKEDGYDWSEVKPYGWNELLEDGVVEYLDAEEEETALIIMSPEALSDANAKKAGLDIEPEDDPLRRNDPPLVRGGEGFTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNFDQRMETMANILYYPQKPLARTMAMDYLKFRELPAGQNAIVAIACYSGYNQEDSVVMNQSSIDRGLFRSLFYRTYQDQEKIVGHAVLEQFEKPTRSDTLRLKHGTYDKIDEDGIVAPGVRVSGEDIIMGKTAPMAPDAEELGQRQKQHIKRDVSTPLRSTESGIVDQVMLSTNSEGNRFAKVRVRTTKVPQIGDKFASRHGQKGTIGITYRHEDMPFTREGIVPDLIINPHAIPSRMTIAHLIECQLSKVATLRGDEGDATPFTKVTVTQISELLRRMGYHSRGFEVMYNGHTGRKLVAQVFLGPTYYQRLRHMVDDKIHSRARGPTQILTRQPVEGRARDGGLRFGEMERDCMIAHGASSFLKERLFDVSDPFRVHVCDICGLMTVIAKLKKSTYECKNCNNKNKISQIHIPYAAKLLFQELWSMNIAARLYTKRAKDDKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN43</accession>
    <name>A0A1C1CN43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN43"/>
    <dbReference type="STRING" id="86049.A0A1C1CN43"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07554"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08791"/>
    <dbReference type="eggNOG" id="ENOG502S40X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650919" description="Extracellular serine-rich protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="23288" checksum="2006F09FD801ED05" modified="2016-11-02" version="1">MHSILSSTTLVFGVLATSVLASPQYGDSGSATTSASASSSTAGVHAVKVGPGLSFTPDTVTAAEGDWVEFTFGSGHSVAQSTFDAPCMPMDGGAGVYSGFPNDGDIWRIQVNSTDPLWLYCSAVGHCEGGMVMVVNPPKETSRMLTMRNRSSGNTLDAYKSAAANAQASSPETVQGGVFGAASDDSSSSSSSASGTASATGDSASASSSGNAGTSNVISNGLMIMGAVAAGAAAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNY3</accession>
    <name>A0A1C1CNY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNY3"/>
    <dbReference type="STRING" id="86049.A0A1C1CNY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07056"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05799"/>
    <dbReference type="eggNOG" id="KOG1549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF21">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE (PLP)-DEPENDENT ASPARTATE AMINOTRANSFERASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="1">
        <location>
            <begin position="100"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="497" mass="55198" checksum="B28F30D7B5A2A2DB" modified="2016-11-02" version="1">MGVMKLLFDYRGSAEKIHLHVAELAVTFLLERSVTLDSPPYDGDNVARNGQSFRGKQNRNKFEARLLSPSPFQPSRIMGSTTFEVSAIRAQFPALNQKQVFMDNAGGSQVLQSVITSISDYLSRTNVQLGASYPVSQISTKKFDGGHIAGAKYINASPREVVFGPSTTQLFRNLSVALKIEPGSEIVLSNLDHEANLAPWVQLAEWKGLTVKWWIPSKNTNSNPKLEPEDLRQLLTDKTRLVCCTHTSNILGTVTDIAALAKVIHETNPNTLFCVDAVAYAPHAAIDVKALGVDFYSFSWYKVYGPHVSMLYASEKAQNELQSLGHYFKTRNTLEEMLGLAAGNYECVQSIPKVVEYIQQVGWDAIAAQEEKIQEILLSYLRSKPDIIKIYGESSSDRKLRVPVISFRIKGQSSLGVIDAIETRSDFGCRSGHFYSKRLVENVLGIPDGDDGVVRCSLLHYNTAEEVEGLVKVLDDVIKEEAGKDVKDPERKHVADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPM1</accession>
    <name>A0A1C1CPM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MIOX1</name>
        <name evidence="15" type="ORF">CLCR_07398</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPM1"/>
    <dbReference type="STRING" id="86049.A0A1C1CPM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07398"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05540"/>
    <dbReference type="eggNOG" id="KOG1573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="175"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="253"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT50464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="319" mass="37220" checksum="231BFAD4C742AB9A" modified="2016-11-02" version="1">MSVILQQPSHPPSFRTDRDGQAFEALCDEIEHADIAADQAFKIKQQTDKDEASKFDAGKDKARFRQYETACDRVKNFYLEQHTKQTVAYNLKARHAFRSKTRAEMSIWEAMERLNTLIDESDPDTELGQIEHLLQSAEAMRRDGRPRWMQLTGLIHDLGKLLFFFDAEGQWDVVGDTFVVGCAFDDRIIYGNKSFCANPDFNDPIYSTKSGIYTPGCGLDNIMLSWGHDEYLYHVVKTQSTLPDEALAMIRYHSFYPWHQQGAYKDFMNEKDHDMLKAVKKFNPYDLYSKSDERPDIERLKPYYLELIDEFFPTKVLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ96</accession>
    <name>A0A1C1CQ96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PGS1</name>
        <name evidence="14" type="ORF">CLCR_06893</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ96"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06893"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05335"/>
    <dbReference type="eggNOG" id="KOG3964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT50679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="579" mass="64433" checksum="78EA800D97BD263A" modified="2016-11-02" version="1">MFARSVGVGGRVLRSSTRTTRIFFPRPAAKRIVTRRFSSSSSSSSSSSSASASNGAAPTVHPLAGVASQLDHVAPRFEIDPDNIHILDGPAAFYETLKAKIRGAKRRIYLSTLYIGKTEHELIDTLREALEANPDLELSILTDALRGTREDPEPSCGTLLAPLVTQFGDRVKISMFHTPNLNGWKKKYMPKRINEGWGLQHMKLYGFDDEIMLSGANLSDDYFTNRLDRYHLFASKELTDFYAAIHDAVCDLSYQLIPSDDRPGGFELLSPHERGYPDPLWHTRRFKSYAKETLEPLIHKRARQKMFPVEFTNQKTFIYPLAQFDILLGQPRNIALLDYEFAQYTSTEKPAITKLLTNLAEDERLHKSTWAFTAGYFNIDPDICNMLIAAAPEAPDVLTPGKKAYYDKSCTVITASPWANGFYGSRGVSGMLPAAYTLLSRRFLRTVSSAGKQDVIQLKEWRRGTVGEPGGMTYHAKGLWVTLPPQPNAEGNLVEDCGPSVTVVGSSNYTKRSYSLDLEIGAMILTGDEGLKKRLKREVENLEADATVATQDTLARVDRRVGLKVRLALWLVEALGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQA6</accession>
    <name>A0A1C1CQA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQA6"/>
    <dbReference type="STRING" id="86049.A0A1C1CQA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07581"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05360"/>
    <dbReference type="eggNOG" id="KOG1672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="231" mass="25874" checksum="750D5E7195F5B8C9" modified="2016-11-02" version="1">MGLENGKSEHGNAEPRSNAEDQDADAILASLEEEDDTSYRAQRMQEYNSAATTTVFNTAKQAYVTLKSDDEALSFTTEHERAVVHFFHPDFARCSTMDSHCEIIALKHAEYADGDVAFARINVNHAPFVVEKLGVRVLPCVIGFVKGVVKGRITGFEGLCWDGKEGSVEVTRALEEAIVDWTVVRKRLLLRHDDDDDESGEDDNAPDRRKTGRRGIRDRKQTVGDEDDDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQC7</accession>
    <name>A0A1C1CQC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQC7"/>
    <dbReference type="STRING" id="86049.A0A1C1CQC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06756"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05331"/>
    <dbReference type="eggNOG" id="ENOG502RM8C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="175"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="611" mass="67283" checksum="D6AAA3B3ADD27AFE" modified="2016-11-02" version="1">MTLEMGSPQTGLTSADRKEDIKAEAAIAVPARSREERQLHLINEIKKLVADCEDFIGLVPGPRGVPEIVVSPNLKKDKWTIIRDAQETFTHFLSMRNPSGKGNSCGSSRHCGKVFKAETDAEARGPGGSISLSVQRPLKRHRSRKSAVRDPAYAKSRHGGGGIRVVEASASQIRVDDDKALAEWYREAFLGLQQVSCRLVAKIWIKKIHPKKQSTHPYNGQMPRNTTPDSDRTRPPYWPIDVRHREPDHIGKDERTQLLVHLLMNTPQPVVTNPPPDPVHQQFVYAQDLLECLEPKKGERELTNERWDTIEQIIRTRQMQEQYAAGEIGLTLADGDTLIFLADFSNTAPSKLGAINSDDDELEFEGNAPGISSDGSDAAAENREPTPDTSTQTSPADQATFEGSVPISRLRGSADTMSFPGRRMATRRSRPSFIGGQVPPSIPIRTDASFCPELAMSMESSMPHGDAAMLSLVGMTPRLPSLTFGRMDNHTGTSELMHITGHSGHPVANLHLSNWPEIPPDMGPDPPAETFGIPPTMTPSSMRHPYFGAERLDAARDLQGGMHPAMLGPVQYNDYGDGTRRALPFRAVDPQHPTMMPTQDVNMGMMGGHFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQD4</accession>
    <name>A0A1C1CQD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQD4"/>
    <dbReference type="STRING" id="86049.A0A1C1CQD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06734"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05323"/>
    <dbReference type="eggNOG" id="ENOG502SIM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="734" mass="81196" checksum="0F7018E0782F2E5B" modified="2016-11-02" version="1">MCTLPSARRFLLPAAVILILLVVLRVLSDTGSLRSSHDALLQAALQRELSNSAKITLLYNASAHPHLTAGRKATYRPPSHALPLPLAHPVIKQFTHCPIPANEHTSHIRLPEILYNISLSPMSASSGPDKRAEDQNGGQLESPPRAKTSTTRFFNPAIIPLPYWAHTARYILVSRVVTSGFHQESQICLADICLPQQQQPSSSSSSASTSQGQTHLPPDTRPCTPSDHFHLGSGGGLRCVTEPLKINIPPTPAEKCEDAWLAFPDIPGFHDPRVFWSGKGEPLILVNSASRYGCVGLWIVDLRVVYPILETILSREDSDPGLVRRDSGGEEGREVAGNGVSLGFKPSMSYPHLTEITRNPRGSRASVEKNWVLWFPSGEEAYVQYDLLGDPLLSQDEAGLEAGQDLEGLARLGLGGNQSQDYRDSNVTKIKGHADNSTTKPRTKGKRTWTEKERRRGRTFSKLIGNGFTTPNLTHPHEQPCFSAEEGDFEDSFGSIGHWHQGSNSLRLILCTRAQARTDPACRDDDHTDDDNPGGEAMGAVAGGRSVHFAIIHRKFSNELDLPLRYERYVVVWESREPFQILGVNRLPLLMRDEWAKPWTKEENWPVSGEAELKRKSNATMKMAYREGGSKLMRRGVHEREVGEDDGFDKNPAYFTYTPSLAWTWRPHSAAANQEDENDDVDYMSQLGTGYLGDDVLVGIGLDDVNQAFARVKVDSLLNCLRLCPGVRFAEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRH7</accession>
    <name>A0A1C1CRH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="3">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_08512</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.13" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRH7"/>
    <dbReference type="STRING" id="86049.A0A1C1CRH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08512"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09731"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2545919at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT51099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="465" mass="49907" checksum="875DFB3DA5012EEE" modified="2016-11-02" version="1">MSESGSSSTPPLKNPKLSAMSKAFAHVDLDGHDLPPSPVPSSPRSGRQYALATQLVYSEGNDQYNASSVPIYQSATFKQTSATGGVSNDYDYTRSGNPTRTHLEKHLAKVMRAKRALVVSSGMGALDVISRQLRPGDEVVTGDDLYGGTNRLLKYLGTHGGIIVHHVDTTTPEKVQEVLSEKTAMVLLETPTNPLIKIVDIPTIASMAHAANPACLVSVDNTMLSPLLQNPLELGADIVYESGTKYLSGHHDLMAGVIAVNDEALGERFYFTINASGCGLAPFDCWLLMRGIKTLKVRMDAQQANAMMIAQFLESAGFKVRYPGLKSHPQYDLFHSMARGPGAVLSFETGDIQLSERIVESAKLWAISVSFGCVNSLISMPCRMSHASIDAKTRAERGVPEDLIRLCVGIEDGEDLLDDLQSALVQSGAMNVTLDGIYAKNATVGDEHPAEGEHLAAKAAAINEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRQ4</accession>
    <name>A0A1C1CRQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_08599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08599"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06877"/>
    <dbReference type="OrthoDB" id="5537330at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="286" mass="31639" checksum="B8ED3A2356DF69D0" modified="2016-11-02" version="1">MAAQPTDSTPTPPSTEQWDELSRDVKAQLLQEMGDESWYLIIATVLTVSDRPHLVAGFWSYLTAHDASFSTSEAQARLSDRFRDLLLKQLTLIGAPQMLSALIPLANAQTDGKGVEGRGELDLEQWSNTTFPALHARGVETITSVYGNLWQNIFRSFGPHRPQVGLHELTIVYGLYLADFTYLTPLETELVAFTSIICQGLRGPALWHVRGLGRLLGARGANDGTDKMRRIKDVVRGVKVAVSTVVEFCGPEMVKRSGLDATDGRLGWPARMAECRRCGERAWRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRS4</accession>
    <name>A0A1C1CRS4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRS4"/>
    <dbReference type="STRING" id="86049.A0A1C1CRS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09310"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06862"/>
    <dbReference type="OrthoDB" id="4367626at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="109" mass="11854" checksum="B332C166BADB2B66" modified="2016-11-02" version="1">MTTTNEANGLNGVHEAQKSALVGVDEFLTHQTYDYLICGGGTAGLAIAARLTENPDVTVGVIEAGKNRLGDPLVDVPALFTQMLGNKEYDWAWDTIPQVRSDHMLRLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRU0</accession>
    <name>A0A1C1CRU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">DBP2</name>
        <name evidence="19" type="ORF">CLCR_08080</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Associates with polysomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRU0"/>
    <dbReference type="STRING" id="86049.A0A1C1CRU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08080"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06842"/>
    <dbReference type="eggNOG" id="KOG0331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002151">
        <property type="term" value="F:G-quadruplex RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071042">
        <property type="term" value="P:nuclear polyadenylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="149"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="352"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCT51236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="538" mass="58688" checksum="EBB304535EFEEE72" modified="2016-11-02" version="1">MSYGGGYGSSRDGGYSNGYGGGSHGHSSGYSNGYSNGYSGGYGGSNGYGGGGGGGDKMSNLGAGLKEQSWDLAALPKFEKSFYHEDPAVTARSQRDVDEFRRKNEISIQGRNVPRPVETFDEAGFPSYVMSEVKAQGFAKPTAIQSQGWPMALSGRDVVGIAETGSGKTLTYCLPAIVHINAQPLLAPGDGPIVLVLAPTRELAVQIQQEITKFGKSSRIRNTCVYGGVPKGGQIRDLSRGVEVCIATPGRLIDMLESGKTNLRRVTYLVLDEADRMLDMGFEPQIRKIIGQIRPDRQTCMWSATWPKEVRQLASDYLNDFIQVNIGSMDLSANHRITQIVEVVSEFEKRDRMIKHLEQVMEDRNNKILIFTGTKRVADDITRFLRQDGWPALSIHGDKQQNERDWVLNEFKTGKSPIMVATDVASRGIDVRDITHVFNYDYPNNSEDYVHRIGRTARAGKKGTAITLFTTENAKQARDLISILQDSKQNIDPRLAEMARYGGGGGGGRGYGGRGGHRGGGRGGFTASNAAPLGRSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS24</accession>
    <name>A0A1C1CS24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative WD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_07973</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS24"/>
    <dbReference type="STRING" id="86049.A0A1C1CS24"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07973"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06778"/>
    <dbReference type="eggNOG" id="KOG0306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000178">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="419"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="500"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="599"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="688"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="827"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="948"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT51307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="969" mass="107226" checksum="77E070FEE1E34239" modified="2016-11-02" version="1">MVKSYLKFEHSKTFGQICTTAANVVWDPTSDHEDLTTGRGGAGCAYVGANEDVLVWDLKKSEKIREWHVEDNSALVTVIHRSLVDLDIFAVGYDDGKIRIWDARTATVIITFNGHRTAISQLTFDQSGVRLASGSKDTDIIVWDLVAEVGLYRLRGHKDQITSLNFLSPEDAQDGTDDTSTSQGFLLSTSKDALIKVWDLSTQHCVETHVTQTNGECWALGLAKDRTGCITAGNDGELKVWSINQSVLQEKLGTSIQEGHSILRERGALYRHGRDRPIAVTFHPRRDLIAVHGAEKAVELLRIRSETEVRKSLARKRKRRKEKEGPADTDSGVDVADDTEEAADISKATGADVFVPYVIVRTGGKVRSIDWAGGKSGKSVQILVATSNNQLELFDVSASEKRKKSSETPEYNRTLSVDMPGHRTDVRCVAISSDDRMLATASQGSLKIWNTKTQTCLRTLDCGHALSLTFLPGDKIVVVGTREGTLEVFDIAASILLDTIDAHERDIWSLQVSPDGKSLVTGSADKSAKFWQFKVIQEEVLGTTRKTSKLSLVHTRTLKVADDILSVCFSPDERLLAVSTLDSTVKVFFVDTLKLFLTLYGHKLPVLSMDVSYDSKLIVTSSADKNVRVWGLDFGDCHKAFFAHNDSILAVKFVPTNNEGNGHHFFSASKDRVIKYYDADKFEQIQKLDGHKGEIWAMAVAHSGEFLVTASHDKSIRLWNQTDEQIFLEEEREKELEDLYESTLLTSLENEANELADPNGNAAEAGPAGKQTAQTLMAGEKIAEALELGLEDLRTMQAYDAARKGGQKAAVPQRNPVLLAHNNVSASSYVLSVFQKIPAASLQDALLVLSFSQIPALFTFLALWAQEERATPLTCRILLFMLKTHQRQIVSSRQMKGMLEDVRAKLRRTLTRQKSEMGFNLAGLRVLGRRVREAAGESEFVDEETWGDAQNAAGQKGQKGRKREFVNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT11</accession>
    <name>A0A1C1CT11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM6</name>
        <name evidence="2" type="ORF">CLCR_09057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT11"/>
    <dbReference type="STRING" id="86049.A0A1C1CT11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09057"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06459"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="240" mass="26775" checksum="E3D0AB4F803F212E" modified="2016-11-02" version="1">MPASRLPSPENDVFAIDTTLVPERDNKKPSTTVITFDNLLPTDKPLLLHEDLQEGCGGQLWPAGMVLSKYMLTYHSSGSLRGRSLVEIGAGGGLVGLAVALGCELDDVQRIYITDQIPMLALMKKNITLNKLEDRVAAEVYDWGTAPPVSILPSGSRHPDVVLAADCVYFEPAFPLLLQTLRDLIGPSTTCYFCFKKRRKADMRFIRDMMKTFHVDYVDYDGKEGDQRQGIFLYSVTRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT51</accession>
    <name>A0A1C1CT51_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative F1F0 ATP synthase assembly protein Atp10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT51"/>
    <dbReference type="STRING" id="86049.A0A1C1CT51"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08715"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06409"/>
    <dbReference type="eggNOG" id="KOG4614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17089at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="387" mass="43723" checksum="1EBB969DB345E3A1" modified="2016-11-02" version="1">MGREDVLALFVTLALRPHRCCVHKVSRLSPRLTRYASTSSQNKTTLPPKQGAEAITRPKIPLHVGLDRNPESVSAISRIPIPRGVRGEKFTPSVLARPLGVEHPPRPGQNSPLDTRTLRERHEEFTSYDKALERRRVYLRTFFRPYFQEWRGMDHHKGKSFVSSPRLFKREKALYFPNIWGQTLAKEGDGPDGGRDTTPLLLGRVSLIGIHSNSWAEEMVNSFIGEKSNPELSRLLDQNRARLQRVDINVSGDWMRALIVRTFSGRIRQNIPEEQWSRYFKIKLPRDIRRGLSDEVRDAMGFLNTQVGYVYLVDSSCKIRWAGSAYAWDGEVDGLNAAVQRLLQEEESLGQASSKPLPSSASTVQRPRVPPKTSTGKPNAIPNAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT61</accession>
    <name>A0A1C1CT61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD-dependent protein deacetylase hst4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT61"/>
    <dbReference type="STRING" id="86049.A0A1C1CT61"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08275"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06413"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01407">
        <property type="entry name" value="SIR2-fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="78"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="543"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="610" mass="66914" checksum="CBC2D9A871B75CDC" modified="2016-11-02" version="1">MEFDQISELSSPLSSIPSSPLSSPPASPTLPPGFQVVTPPPSQHAGDEMPRPRKRRKIEPKIRTTQYLDLTSDTAQSEYDRREALDTLLKAVRNRRKIVVVAGAGISVSAGIPDFRSSHGLFKSLRGEHKLKSSGKMLFDASVYKDDHSTAEFHKMVRKLSKMADNAKPTLFHRFLARLAVEGRLLRLYTQNVDGLESSLPPLATQVPLSHKAPWPKTIQLHGGLEKMMCQKCRHISDFQAHLFEGASPPLCPQCVAADALRTTHAGKRSHGVGKLRPRIVLYNEHNPDDEAIGAVTTADFRTRPDCVIVVGTSMKIPAVRRIVREMCQIVKDRREGTTVWINHEPVPPGKDLEDCWDLIVSGDSDEVARLARLREWDDPSTDMAENYTEADLDRVRSRQGEIEVVIPPTPKKSETTASRLLSSVEINTMTPPRSQNGDEASKTGKKPTSTTPSPIRIKLNVTARSKEASAKQATVKNAASRGKSLLDLLNGQENKTKTARSKTSLNKKAKVTKIRASGKLAKQAVITGRVTKPVVEVNKAGVKPSLPEPLSPRRDANEAPPAPISEFSSVEASPAPETPPSTSAGEEWRNNDTVSPTGRIPSDMVRLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT63</accession>
    <name>A0A1C1CT63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT63"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09254"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06436"/>
    <dbReference type="OrthoDB" id="5278621at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="116" mass="11498" checksum="67E6C4784A42F4E8" modified="2016-11-02" version="1">MDGDHTGKNLDAGANAATKAQDLTEGIHEGAAQGAAAGAKTTGQGTSMFSKDGAVGHQFTGAGQFGRSADSAMVNRRAGMRELTNDPTYTGAIGGAGNKVGGPLAEDGMIGKNFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTL8</accession>
    <name>A0A1C1CTL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTL8"/>
    <dbReference type="STRING" id="86049.A0A1C1CTL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09078"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06269"/>
    <dbReference type="eggNOG" id="ENOG502S7E3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2550114at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="178" mass="19652" checksum="4D8B62347F2AD059" modified="2016-11-02" version="1">MDVFYSYTYGTAIWLGLQAVPLVAFPKLVIMTLSEEGHQTSDVEIYLSRSLGCALMTVGSIILFFTGTIPLTSSISEPVSLGDNDPKAPYARPILLVSSFFHSLSFIYCYTSYVNYHQTGFVLGALGYGIMASVGLWTIIFGDTTARLSKRTGADKRTSGWPFKNTQAYDKRKDRKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTP5</accession>
    <name>A0A1C1CTP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative 2-hydroxyacid dehydrogenase UNK4.10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTP5"/>
    <dbReference type="STRING" id="86049.A0A1C1CTP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08790"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06278"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000282">
        <property type="entry name" value="Glyoxylate reductase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF269">
        <property type="entry name" value="HYPOTHETICAL D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="38"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="124"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="336" mass="36558" checksum="631A11E1640B92DD" modified="2016-11-02" version="1">MSARPKILLLGQIDHAQEAWKSLSSLGDLVTPSATNRADFIQECQSGQLDGVVAAYRTFQSVSITGFFDEEIVKALPKSWRFLAHCGAGYDQIDADACSARDPPLLVSNVPTAVDDATADTAIFLMLGALRNFNTSMVALRRGDWRGNPPPALGHDPQGKVLGILGMGGIGRNMKKKAEAFGMTAIYHNRRKLDSSQADGAAYVSFEELLRQSDVLSLNLPLNPKTRHIISTEQLKLMKPSAIIVNTARGAVIDEAALVDALDNGVIAGAGLDVYEEEPKIHPGLVGNERVILLPHMGTWTTETIKKMEEWAIENVRLALETGKLKSPIFEQKDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU64</accession>
    <name>A0A1C1CU64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_08894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU64"/>
    <dbReference type="STRING" id="86049.A0A1C1CU64"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08894"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06089"/>
    <dbReference type="eggNOG" id="KOG0715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="67"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT52042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="312" mass="34229" checksum="390FF94B34E782CC" modified="2016-11-02" version="1">MILRPASISLSIAHPLRRSSHTTLPLATSAACTTATTTSSTCVARARGHRPFSHTRRLEQTGNAPQNHYEVLKLPMHATKSELKRQFYILSKETHPDVNRQDPQAADRFAQISESYSVLADPEKRKRYDRDVMRAQQQHDRHGRHHGGGGGGSRSGTYAGHRPPSGLSKRRSVFKGPPPSFYAHGGGSARTQQDAQARAHQAAGQEYTGGTFDAGAFSDDPNATFDSRPTFKTQTHEDYRRMNRRQAELAAARVAVEEDNFWARFTIVSGIIALSVGVGTLILKMASTPRGGGLTRADGSRRDSAKNEWTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUJ7</accession>
    <name>A0A1C1CUJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08115"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05988"/>
    <dbReference type="eggNOG" id="ENOG502RR9A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4117985at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="732" mass="77673" checksum="C612C2B8D0BAE0E6" modified="2016-11-02" version="1">MVSHTHTRSRSKGSFSIFSLDTIRSFSRAGSRQGKETSSAYPTRTDPCSASRIPSKDELRAGAESSLSHRCDPNNQPPPTPEPRSVNHGGEASVESSSPERVKIQPTPTAPREPQRFNSIRRRAHRLRPKSWLPFARPVEQPPCPRSISTQLPKTASTSTVARSVISAPILTSTTNVSVARAEGVHCGEISDAAFSQSTWNSQVGWVATDGQDSGDGHQDPPPGTPALSPLVEDKVHQLADGTALKRGRILRLRNVIRNKIVTGPQRTQAATSNPQQTEKQGGQTRVADQPALMRGSSSRRAETINLYKGKIKGLTGNAHIRRRSLNTTKSIAESRVAEDPPLLGDIIDVPTTDCAAEHSDNDSPFGSLTKSFASAVDKLDFYSTLPRNMSFLRSRSSLFNLKKADKAASSPKEAGQLFPPISPSKPAPPVSQLIAASSRAKGSTFSTPGSNARRRPPVPQRGVPSVANTSSGNPKHNALAAGRSVLSPIVFSNEKNGYVASAPELGDSKGINPLRMHPPGTMAVPLAVANRTVPIMPADSTTPQAGARSQAATPAAEIDTDSDSMSLEDAPIYSPSLGDLSQYARDTPRSAKVALSETGKAQGAAPTPTRSPIKNRSSAKGHSGLLKKSRSGVSLFSRAKPDNNSTVTGGPLHQRDANQKLTNIAGNVVKKSRSLHFGGLFRKDEHADLQPAAVPASPFQPATPSPLRKVMRYGSQSTGGGSSPTALSARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUM8</accession>
    <name>A0A1C1CUM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07928"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05950"/>
    <dbReference type="eggNOG" id="ENOG502RJV2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4150782at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1187" mass="129231" checksum="2F07953945FF5233" modified="2016-11-02" version="1">MPFLDRVWSPFLCCFPVQPREEHPTSDLQTLPSALHLPASQVPHAAGQCRSNQADTDALHELFRTSSSIRGYRTASIPSGSHVQREPSFDADFKFGLQDHPRKQPSRLEQLGNHIKQKLSESGLSKSGSGSHIASEDNAHNPIEQDNTKLRISNPEISLSQRSTGLLDLLQSRTASEGGYDSDAKSIQTAMLKSREGTMKLSPTRAQTLLSPMAALRHIATDGASASPEARESDDDDLRPQPDLRVLSSHSSTTACTKDLSEVEQESPSTDLGQLNTRASVGAIELLPSSVSATMSGSPAVLAKEADPFTTAPSSNEFSLPAQHDTHFAEMLRSQGDKISAANRESLITNGTNPRASLMSSLDPNLLEFISRSGESLAADAAGCPSKDHGADAMVDPTSAVLDKSATVRPATPARENTSRRDVTSLTESERSSVHLYSMRISQRLASPSFVATQSRPNTSYTTSQVARQDSTERRPSLGRTSTSANIVGRITAEHNRRPSDLQTRRLFEGDRTCSRHSSKRKNGSLPESLIASRNPAPLRGTDDGSSSYWSDGEVEQNGLQRTRTTKRNPNSIAIGGRSESISLPIGSSVGSLSVAEESAWFKRKSSQHKRGSEPDSPLQASAKRNRSVSLPDGPTHQPRTWLAHPSHRVQHPTEANETMSVIDAYQLQDARKYNTTESNLHAGGDTGTERLTDISAQTIRDAHDEDMSEIGPLDPSHGGEARPELTSFWSDAGPSMLGTGLLVPGKRSKSEDQEPLESSLNGRPNLPESATNLWQRTFKRVLEESENDPLGGFLTAPRFDRDGRRKSTRSSISTVQLPNEHRVSEADVDPLETRVKNNSQHPMEKSLLEVCMRKPDPLPSVNPRRSIVIMEGRKGVYNTVGPSKTSRKKSLLDIGRRFSVIGSCSEAERTSGASTPLKDLLGLWGRFPSHTRDDRCGSAGAKDGVAVRDFGLECQDENSRSCSAGHLKLNPMFDVPTPESRKMLSFSRGRIGKGQTRSAGSLRAMQTSRVPGVRLQKSKKGLAARWKRLYRTSSMEFQAYTHNYGHRSSIGVGASVEYPELEVVPGSVGWRSDLDGTVETDDGHQRERAGCVQDGLQQPLDTAPWTQAYRDCVGSLSALKSDPHLRRASVDDGPGPAQYGHVALGAMQSAELRDSTVDFESQLGKEKEAAKEGLMRKVESMQPLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUR6</accession>
    <name>A0A1C1CUR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUR6"/>
    <dbReference type="STRING" id="86049.A0A1C1CUR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08573"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05928"/>
    <dbReference type="eggNOG" id="ENOG502S997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2152896at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="417" mass="44950" checksum="DDC2F8F6AE360857" modified="2016-11-02" version="1">MASSKELPTSRPLSGSFSSRHPSTGGRQHSHSVSLSATNPSHRVNRRKSVNAGASSTAQAAIAAALRDQGELVGMPIHHHRRSMGSRKTAESQSMSGRPSMHSYFDATARATPGHDNDALDDNSNDEDNQSSSKNLKSRNRRASEGSHLIKGEGKKSAAELRCDTCGKGYKHSSCLTKHLWEHDPAWAITSKLLISKHQQVQLLEAASVLCNMTVENPTANQFDLEAAAVDPSEDSSASPGFSSSEMQDELSSVETTPPPMSEAAYPVPNSKRFSSSSNGFSRSYRSVASSSYAESFHSPGLPPHRLSGVDFRPSTSGTDDGTLAAATAGLSFGSGTPRTKPSYLGADVPPVPPLPQQYQSFNSKSSDSTLTTVYNPLLQMHPPTLTQNLSDERNYRGHSDDRDIPMDDDEMFRMDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUU6</accession>
    <name>A0A1C1CUU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09006"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05900"/>
    <dbReference type="OrthoDB" id="9981319at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="230" mass="25454" checksum="23BBCC521942A020" modified="2016-11-02" version="1">MPIYQVIHGISLTPYQKSLLAERITVLHSTEYLTPSLFVNVIFHPAEPVGDFFLAGKPYNNGATSPNRIFGTVRTGPKRTKERFDNFAKKLEAAWYEVVNGPKQAGQTNGASGHGGELSKEDRRARKLHIVGFEGVITGIENGVVLPSVSVCIPPLTAGSASSMHDAPLAYVARVWATADDQPTQADNEGTWLKDNMAFFKEQAEVYSDQPFQDLLKELRERPDLRKLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUX8</accession>
    <name>A0A1C1CUX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUX8"/>
    <dbReference type="STRING" id="86049.A0A1C1CUX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08464"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05873"/>
    <dbReference type="eggNOG" id="ENOG502S8TM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="50932" checksum="A410243305FFA83F" modified="2016-11-02" version="1">MAEVFGNALYNISALSGRDDGLFCHRDPETISSSSVFLHGDDYHLSHSYLINDLDLWRGELVHMPLTTRGWVLQEEVLANRTLYFGARQVLWDCRSSRACETYPLIACDERQSMQQKKVSLETRSAFEEKRQILRDTELESITSIVSFAKGGTGTTLAPLPTVQTDFPAVWARFISHYSTRALTFPTDKLLAIAGVARVLSRAVCDRFVAGLWESHLVKGLLWYIRASTVTERPAEYRAPSWSWASCQGYVIHAEPFQHSWTVAQALNVVCETASGDECGVVNSARMTLQAYCLCLQLDEHGDWTAFYGRHKVPRLLVHLDTSEDITKLGRIFGAVIRTTAYRLTKSDVQPEEKGKILLAAQGIILATTSTKLPSPPLHVIPADNSQAPTMGGDSQYRRVGYFALEDRKGGTLTPKWVVPGGRIFHAPSQLASDQSPGQPTNFDSTGQQEFMSTLDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV93</accession>
    <name>A0A1C1CV93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_11420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV93"/>
    <dbReference type="STRING" id="86049.A0A1C1CV93"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11420"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03816"/>
    <dbReference type="eggNOG" id="ENOG502TBQN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4121134at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01082">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone" evidence="8">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT52414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="114" mass="12715" checksum="D89F2F6C0484D116" modified="2016-11-02" version="1">MSANGETVPQGTNEVTDVGKGKGKATEPAEITMEEEDDDEESAEEEEQAEPEEDDEMDEIDLDNIVEGRTRRKQINWAEAAEKSKDAGDDLDDDEDDEDDDFEAPDDEDEEMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVC5</accession>
    <name>A0A1C1CVC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OBAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVC5"/>
    <dbReference type="STRING" id="86049.A0A1C1CVC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11076"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03849"/>
    <dbReference type="eggNOG" id="ENOG502QR3B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1901244at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360:SF0">
        <property type="entry name" value="OIL BODY-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="94" mass="10649" checksum="3A40498CB5046BF3" modified="2016-11-02" version="1">MANRNGSYGKLYHFWQVDRGDELPLGPPNLMGSLTEFQQLDVDKEMAARNNELGIDQAEKRKVREPINLPGVPENSDSWWKEAKSAKRGIYSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVI2</accession>
    <name>A0A1C1CVI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">lcc1</name>
        <name evidence="15" type="ORF">CLCR_09582</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVI2"/>
    <dbReference type="STRING" id="86049.A0A1C1CVI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09582"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03930"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF87">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651067" description="laccase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="299"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="450"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="671"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="56"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="189"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT52534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="864" mass="90324" checksum="1D3C307E6066171C" modified="2016-11-02" version="1">MKSLLYTAALLPLASLAVAGKPHEVDEVVVVTTTRTVTVCPITDYWTCAPDGPTGTGAWDDWGSTSPTGVVTTTTKTGGPATTTPGSGNGGDDDGHGGHGGHGSGSSTTPVGPGTTSSSNDDGHGGHGGGPGSRTSSTTPAGPVTTSSSTDDGHGGHGGGDSTSSTTTSYNHDHPGGSDSTTSSPVAPTLPTYTTSAGTTSSHGSDGPGKDSSTSSSPAGTQSTSGVTTSASLTTSSSTTKTTTTSTSCVPSQTVSALPETGCSDNTANDRSKWCGKSVGDDTHVHYESGDTKYFQLTITSGQADFDGTSRPSFLINGGTPGPLIEVNYGDWVEVTVTNLMTDNATTIHWHGVRQIDTNDQDGVPGVTECAIPPLAVRTYKWHASTYGTGWYHSHALSQYGGGIRGPVIIHGPSTANYDYDMGTVMVDEIFSQTIFQMAWNIARLRGPLPAAVNYMLNGKNKAVDGTKGKSAEWTVHPGKKHLFRFINSSAQASYVIHFDNHKMTVISADYTPIVPYTTDTLYINPGQRYNVIVEMNQTPGAYFLRAITQTGCGTQNLNNGLGSLANGIFTYKGSCGTPVTDTLTPTIGSTLQTDCKDEPLASLVPFVQKNGGSQDKFASDAQLLPGGNAAQQAFDGYGPITRWYFGPMGSVSSNTAGTLGSSAVTVDYDNPTLKNMATLPSVGFNSSIYSNAVVLDGTPGDWVYFVIQNNFQTSHPIHLHGHDFSVLGQGKGTFSSAQASTLNFANPIRRDTALVFGIPGQGGAPQGGWTVIGFQTDNPGAWVMHCHIIWHADGGMALQYIEQPSAIPATDYYTSESFQSECAAYDAYVAAGGDRPASYESGLKRDLQRHRYGEKRFGRHGMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVS0</accession>
    <name>A0A1C1CVS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CUTC</name>
        <name evidence="3" type="ORF">CLCR_10800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVS0"/>
    <dbReference type="STRING" id="86049.A0A1C1CVS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10800"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03932"/>
    <dbReference type="eggNOG" id="KOG4013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="223" mass="24050" checksum="83A810A2A99E729D" modified="2016-11-02" version="1">MTLLEVACFNVQSAIVANEAGADRIELCDNADLGGTTPPLRWLDEIHGIVKIPINVMIRPRGGDFVYTDPEFQIMKDAINVFKSTGMVSGFVFGVLKHDRTVDVERTAELVRLADPLPCTFHRAFDETTDLDQALEDVLGCGIHSILTSGGASKAIHARETLARLVKKADGRVVVMPGGGVRSTNIGALKESTNASAYHSSALLGSNMVANAQEIEQMEIESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVV8</accession>
    <name>A0A1C1CVV8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVV8"/>
    <dbReference type="STRING" id="86049.A0A1C1CVV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09788"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04066"/>
    <dbReference type="eggNOG" id="KOG2651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258156at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="148"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="667" mass="74277" checksum="B05E177F20AA0CED" modified="2016-11-02" version="1">MTHFSRHRPGGLRLPLDPAWKSEDEYVQSVLSFATTSDLFRNLCGGVHILDFLTREPDLYTTVLPQEWRDWFERVDIDRVLDLLMRDDLARYADRKSENADTTTPHPPASLVDYVCTVRKHSLKRTFTPHSEDISELPLHVAVGMKTKKVHEVTNVAAYVSQLCDELSSQHPDPEPLTVVDFGSGQNYLGRTLASPPYNRQVVAIEKRHHNITGAKSMDVHAKLAKKEKVMRNKKEWKRQLGLRNGNPNGTKDVTLEPLQPPPPLPVEDTPSKSPSEEVSTATALDPSTTEAKMVGVEFEQGKGSMTYIEHDIQDGYLEDVIYPASPKSARQPQASQDQAQGQPDCCSAPTRREIDGDEHESSSDGRTEIIPPSLPKQPPSIVISLHSCGNLTHHALRSLVLTPSIRACAVIGCCYNLLTERLGPVTYKLPQLRPNHPRLAATGAAYDPHGFPMSKTLEDFVPPTDPEALAGVRLNITARMMAVQAPYNWGPLDSEMFFRRHFYRTLLQKILLDVGVVKQCADPGMPSQVAGGSITGRDDRGTPLIVGSLRKACFATFRAYVRGALAKLRADPVDGDMVAQLTRHLLADDTTIDAYEARYAYAKKNLAVIWSLMAFSAGVVESIIVTDRWLFLREQECVRDAWVDVVFDYAWSPRNFVVVGVKEGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVW7</accession>
    <name>A0A1C1CVW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09994"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03980"/>
    <dbReference type="OrthoDB" id="4165735at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="502" mass="57032" checksum="9F99F5424C9A062F" modified="2016-11-02" version="1">MTKRAIVWTPKKLEKLYEALDEIAETGSGVTPWLEALELMHEKTGLSKVQVSDKLRGLAQKHNLKLNREELVRRWAEVSVYFKEADPNTKIVRHSQSPRRSPTRSNRATSRASQRHTQSPKSVNNPNPPKHTQDQLYGTASNEVQGNGEQHNASSREDDAPTNSGCDNRAGNNENNNDAEEPVMMLEIEPYEWDMIHAWRDCMHGKRFLTPMSQDAMRLALSDIWSLLNEGVKSFCKAQPVAHLTTGKMSRPTFELARTFTSGCWRPDVDECLNTLFGDPALNVPLILRAFAAAAITSSLLIDPRQQVPHSITVWRCSPDAARDTKEAMEVEYFENVVAPTLPQLAKQYRHDLFDVFSSLRAPLERHFYPQENQNAEDAPDFAFRKQQHSDWATNVEKAFLDALKLRLRLAKSKSLYEFKLIRQGQKFEAESMVPMVPKAERATSQNLVLQCLSPAISYYQRAEHGRSGPRWPQVHAKVILEGLEVDENAILGVDDPNDNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWE4</accession>
    <name>A0A1C1CWE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative phosphoketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_09616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWE4"/>
    <dbReference type="STRING" id="86049.A0A1C1CWE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09616"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04200"/>
    <dbReference type="eggNOG" id="ENOG502QUUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2532903at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02011">
        <property type="entry name" value="TPP_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003617">
        <property type="entry name" value="PRK05261.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003619">
        <property type="entry name" value="PRK05261.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF0">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="29"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="608"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT52859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="811" mass="91286" checksum="E8B690E4B6D7EFB6" modified="2016-11-02" version="1">MGSVVEGDVSVESISPFGKARSTIKEAPLSEEELKLTDDYMRASLYLCLGMLYLRQNPLLKEPLKVEHLKARLLGHWGSDAGQIFTYVAMNRLIKKYDLDVIFISGPGHGAPAVISQAYLEGVYSEVYPDKSEDVEGLRKFFKQFSFPGGIGSHATPETPGSLHEGGELGYSISHAFGTVFDHPNLIALTMVGDGESETGPLATSWHSTKFLNPITDGAVLPVLHLNGYKINNPTLLARISHRELEALFIGYGWTPYFVEGSDPMSMHQAMAATLEKAVQDIRGYQKKARESGKAFRPLWPMIILRSPKGWTGPRTVDGHYLEGYWRAHQIPLPNVASSPEHLKLLEKWMKSYNPEKYFTEDGKLIPELKKVAPEGNRRMSANPVANGGLIKKPLLMPDFREYSLPVEKGGITDAASMSNFANFLRDIIQKNPHNFRLFGPDETESNKLGGVYAAGKKVWLGEYFDEDADGGNLAFEGRVMEMLSEHTVEGWLEGYLLSGRHGMLNSYEPFIHIIDSMVNQHCKWIEKCLEVEWRAKIASLNILLTATVWRQDHNGFTHQDPGFLDVVCNKSPEVVRIYLPPDGNCLLSVMDHCFRSSNYVNVIVADKQNHLQYLDMEAAIEHCTKGAGIWDWASNDQGEEPDVVMASCGDVPTMEALAATALLREYIPELKIRFVNVVDLFKLIPHGDHPHGMTQRDFEALFTANRPVIFNFHSYPWLIHRLTAQRPSQQNLHVRGYNEKGNIDTPLELAIRNRTDRFSLAMEALDRMPELGNKGSSAREKLLSSQIKYRTIAFNEGIDPEEIRNWKWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWE5</accession>
    <name>A0A1C1CWE5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_09577</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWE5"/>
    <dbReference type="STRING" id="86049.A0A1C1CWE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09577"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04213"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="618"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="11">
        <location>
            <begin position="687"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="825"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="8">
        <location>
            <begin position="691"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="8">
        <location>
            <begin position="725"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT52873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="853" mass="95516" checksum="70E9FED6C8201068" modified="2016-11-02" version="1">MSTQHFFVQDVMRSEDEPRRLQKLHEENARTRWFNIRHHNSQPYLHVYDRFRPLCDLPAGDGADASSTFPTIVSFIGKSGVGKSTLVRAMLLLGSIDAQQVDTEDVSVLASNQSRMAAFKNISSAQGPLPVTRSGHVDHLADPTTFGVHLYKDEKGLCGPPSSPAGYTLFADCEGFFTGAAQTNAERLTSGRGITPAEDDAMEANLLYKAPVTANMSTQDGQGRAESYYARFLYSISDVVVFVTNEDQNITSLLTSALEWAATAVLHSVNYPSRKTLIIVRNGAMGQRQQIIDTESLERLYLDRQTENLWKRSGILETFVNDYNSRQDKYSKHVYDNRDLYDVLFDRTLCFCIPRADDVEEYRDERVFTQYLGLRTLIDEASRRAVSMRSQVWMRYDVASFSQMLFAAFEHFRTSDKPFNFNQVVRINKPHPRSLLSHIANFLRLALKTTYVRGIRAMIPDIVALNLVVWAMRTLHQVADPEHIFDCVSAEDENDVSLAEQCHSAIREFEAKYQQCGYQFANSDPCINGPVIAHQQLHLSPNNKQAYGPFVLRQVLDPNLVGLIRGKFLEHYNTVVTEDRTGRRSMGKPPPDKIKRVREAVMQKYWSHWLDMTSNTTCLACLQVVPENVLHCGHGYCVRCVRELGKPSESFESAWTFEVCSLCGRRTGDNYSHLIRGTPRCSGVRILTLDGGGIRGIIELALIQEIENKLGLGIPFRDYFDLVVGTSTGGIVGLALSMGDKDANTQTSLLTKAFKSFASTTFLHPRAGRLLNRSGLGHFVTSVVMSVGLYQALFDSNPLQAGLERFFGAHTSLFSSAHSASSMLDESCGGDDERIRPKSPSHHQLQQGHAGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX06</accession>
    <name>A0A1C1CX06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">YbgI/family dinuclear metal center protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX06"/>
    <dbReference type="STRING" id="86049.A0A1C1CX06"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10270"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04336"/>
    <dbReference type="eggNOG" id="KOG4131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="46712" checksum="2A6E9EB99F42602B" modified="2016-11-02" version="1">MSSYHVSPFTTAVVSSMRRLYPEALADKSFDNTGLLLEAPFIPSRPRNRNSVLLTVDLTRAVAEEAIENKHSVVVAYHPIIFRPLKYITSGDTQQLSMTLLLAHGISVYCPHTAVDTVPDGMADWLCDIVTGKLEDPEPEAYAAASLPSETEVTTSESGSEAPSKASTRPTSPSAAEHDNDAMTDPFTTPKAKMRLERPNHVHRTYSKPSLPLPTDEFHANVISHTRRVITPSPRAAIDAANLFTGSENYNTSNTGAGRLIEFSTPQPLTVLITRIAHAIGLPKGFAVAIPQGRNLGEINISSVATCPGSGGGVVRGTQADLIFTGELSHHEALAVIERGGCVITLFHSNSERGYLWGVMRDKIEREVESEWAKVRSEESGRKGSSEELQQMLKDESVEVVVSERDRDPYGIVVLDDTVVEGQKINESGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXB8</accession>
    <name>A0A1C1CXB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein SUR7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SUR7</name>
        <name evidence="3" type="ORF">CLCR_10640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXB8"/>
    <dbReference type="STRING" id="86049.A0A1C1CXB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10640"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00074"/>
    <dbReference type="eggNOG" id="ENOG502RKFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5419460at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414:SF1">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="263" mass="29616" checksum="700FA3FE2DC121A1" modified="2016-11-02" version="1">MASHLRDSDHDRTGNGLFGLVSLILLAAGLLFMFFILLAGAIDHGPVNRFYILQADTARIPGAPPVSRWSYWNVCGVRNGRTFCGDQDYSNIHPAFPLDPSSHRTFDTRVGVPRNFVEHHGYYYFMTRFMFAFMLMALFFAVLGLFTGLLALCTRLGSYLSSLMTMIAMIFQAINASLMTAAYIKGRNNFRNNGQRSDIGKYAFGFEWAAFACFLICTILFCVGGSSRREPRTSKRKGFRFGGRRSRSTRSRGSFVQDKEYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY17</accession>
    <name>A0A1C1CY17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative metaphase-anaphase transition protein (Mlo2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_09962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY17"/>
    <dbReference type="STRING" id="86049.A0A1C1CY17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09962"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00346"/>
    <dbReference type="eggNOG" id="KOG2752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262564at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="6">
        <location>
            <begin position="44"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="44"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT53376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="557" mass="60804" checksum="6F40AB761ECE3261" modified="2016-11-02" version="1">MEAIPENEEVKMSAPQDSQTASEFIDQQLALEADAREVLPYKFDKCTNILGPLRQNVFACLTCSPPPASAAQVYTPAGVCYACSISCHGEHTLVELFSRRDFVCDCGTSRLPSTSPCTLRSDPATGSRGVHSQEPHKGNHYNHNFQNRFCACGEEYDANTEKGTMYQCLGLGTIETGGCGEDWYHPECLMGLPRHWYKEQEPEEGNDIVEKKLEDGESEKKDNASHPVPPGFPHEDDFEALICYKCVESNPWIKKYAGTAGFLPSVSNHGGSLALWAEEWKAIGCRTYAQYRDTMLAGCKTYAEYLAKTKPATAEPAPADLIATSSLKRKASDDDIDIRPSSPAKRVKDDNATTSHDANISSGLAQPSPSANGASVADLPAATAQPGEPDSKPQHKHDLLPSSPPAGRFSLFLKADFRDHLCHCPSCYPNLIPHPQLLEDEETYEPSISSDGSSQHHPNGTNGGSSRASLLERGEAALSNIDRVRAIEGVMVYNHLRDKVKEFLKPYAEEGRVVSADDIKAYFEKLRGDSQAIKEARADAGGGDEGEGDNRREQSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYH9</accession>
    <name>A0A1C1CYH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10073"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00426"/>
    <dbReference type="eggNOG" id="ENOG502RQVH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5418627at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="515" mass="54961" checksum="1453319B6B736E4D" modified="2016-11-02" version="1">MYRNTAQNFGHVKCIPPNALPSPDNTSDSDLEILDALDEKRRQLDEEIARFQAAKEREFREFERELRVKRKGTRIGGHPLSEPPSTKPFTPGPSATTSVLNLLASAQNGAANGRAGPKARRDGYMADKVKKPAPLSGPTLSLEKLNITGETTPPLHSLGTPPTPNLLMRSRSRSPTDPNARPTTPPFSQSEKESTPTSTPTPSKDRSDPFAGVFTPAYLPLLESRDRTALVRSPPIPNSAEEETKRLQLDASRKLHAERQKLESSQSLPPQQVSPTIVTSKRTKSTPVLPSASLPSALRTTSGGGRRRKHVMFQLADLKVVDPSSSYEEGPSPEMEEKNDVMEYRDPGTQSDHGSDAGKQNNGSPGLLGEKEKRRGRGRNGRFVSPIPSPLASPSPSPSPSPALQGSSPRLSPAGSPSPTPSSADETGFSGGLAGADDGGSGVGFFELDEELASPGLRDGNPVETFDLDMEDEVLVNEKASAAQQGLGIIPSVQVGSVPIDIVRPSSSFVGSYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYZ3</accession>
    <name>A0A1C1CYZ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MYB DNA-binding domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_09943</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYZ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CYZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09943"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00617"/>
    <dbReference type="eggNOG" id="ENOG502S225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="608866at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052450">
        <property type="entry name" value="TRBD-Containing_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734:SF1">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1 TERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="278"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="278"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="384"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="384"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="64268" checksum="CF61647DB03CB605" modified="2016-11-02" version="1">MNGITEPLPGLLDDPQFQITDLPALTDFHIAPLRNPAPSRHANIPLPLEPVAGKIHNNSRATKSTVRREDESEKRRAPKITPSDVLLAREAKKPHLAISELLEANDGPDMVPTQLPSFISLSVVEKSPIQAPSPLEHGHAQKRLRLDTDGEAVALEMIRHLPRPAQKEDRPNRPAPLLPAMVTGLHEPPPSAALLPSIDVASRPAAPRSTTTSKIHVKDMLTESDPESAHWQAPPAVVVEKQVPCAQETVATQPTPVHANVPATTPSTSCAVPWKDNKPRRARRKWSESETRDLLAGVKKYGMGKWKQILDDPSFNFSERSSVDLKDRYRVCANNDSVPKSETNASTNNPVPEQTAPTEGEGPSLSPMKGTEADSPLEQGHAPKQRRKRRAWTVAEDESLLKGVARHGFQWTAIHDDPELDLAHRRATDLRDRIRNKFPDGYKHAETAPLRSEVKKAEKLAVSSAGTPDIPNPGSAVPAAKNSASVIHNSTPAATPIKTSTPTPTRAASGKVKSSTSASSLTMLLRSDDIDMEPTKEKGDKEKDRERERDQQVGVTLPSFTLEVDDDMDWEDNRLPPLHEWDEIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ17</accession>
    <name>A0A1C1CZ17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related protein Rab-5B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RAB5B</name>
        <name evidence="3" type="ORF">CLCR_10696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ17"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10696"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00713"/>
    <dbReference type="eggNOG" id="KOG0092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="218" mass="23252" checksum="D969ADDEC887DF3E" modified="2016-11-02" version="1">MTFRRTRNPLLAISLPNRIIKFEIWDTAGQERFASLAPMYYRNAQAALVVYDLTKPTSLTKAKHWVAELQRQASPGIVIALVGNKLDLCAESSSGTADSEEDSAAPAEGEDAEGPGSEEAEAEHTDNSDARKISTREAKSYAEEESLLFFETSAKTGTNVAEVFSAIANAIPETSLKGARGAAGGGTQAALSGAANRAEEARVNLNERAKQQKDNCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0B9</accession>
    <name>A0A1C1D0B9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0B9"/>
    <dbReference type="STRING" id="86049.A0A1C1D0B9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00285"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09432"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09433"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT54188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="410" mass="45259" checksum="C915F8CB83EB87F0" modified="2016-11-02" version="1">MSYASDVRLLLTDRDLTALFCQHAGQQENLKDQDWVLLLSWGFEYQVPGLVKYIVQHNPVSLGRLPAEVIYDFLLQYVARRDFDTLQLVVAGANANTTFRTHVLRLLTCYEDPSPSIGAISRVLVDNGFELNGAEISGDPLLLWASKRRQDDLVQLILERCSVDVNARDSEGQTALSLAVISGSLTTMKMLLDAGADANRQGKEGGAPLSYAASMDREEQASLLLKVKDINVNVQDNDGATYLLRAVRLAPGPVVGLLLKHQDVDVNLRNKDGDTPLLRAVMLNAVSVASLLLKHKGVDVNAPDEDGVTSLLRAVKLTRLSMVKLLLEHSFVDVNVRDRSGRSSLWWAVHQGPDAIVELLLERPDIDLGGGAPEPCDALEETSPLEMARKRGYSRMATMLEQRMRQKQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0U0</accession>
    <name>A0A1C1D0U0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0U0"/>
    <dbReference type="STRING" id="86049.A0A1C1D0U0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00992"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01660"/>
    <dbReference type="eggNOG" id="ENOG502S3UC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="124" mass="13854" checksum="58E90B19A2ED5549" modified="2016-11-02" version="1">MLAYHALIRTHHITSRKKVARLKAAAKQLQCYALLRSGGIPGVMYVRGSDQAQVQKWVDNVHGLRYKDYQLVAPVATIAGAGSQSGFAKEGILQEVETMKEMAAHMERQGIQRWWRAAMGFANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0U7</accession>
    <name>A0A1C1D0U7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA recognition motif containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0U7"/>
    <dbReference type="STRING" id="86049.A0A1C1D0U7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00946"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01628"/>
    <dbReference type="eggNOG" id="KOG4206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT54354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="214" mass="23629" checksum="ED84F16C6E8008ED" modified="2016-11-02" version="1">MMTAKSAKESQNTGTPNQTLFVKNLPEKINKNELKRALYMLFSTYGPVLDIVTSRVGAKGQHMRGQAHVVFRDIQTSTQATRALQGFDFFGKEMVRVYTAYWVKSYVKLMLQAIAYGKGQSNIIPKLRGTFEPPTAAATGAPEQTALQKSIFNAPPGAATSTPVENGTKPTETPADTGPHGIKRPREEVEEEDDNEVEMEEDESDAPMEEDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D111</accession>
    <name>A0A1C1D111_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Six-hairpin glycosidase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D111"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00796"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01723"/>
    <dbReference type="eggNOG" id="ENOG502SK90">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2580243at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="72495" checksum="99F9FA41965CDCA2" modified="2016-11-02" version="1">MTVPRKDAYENRLKTLDIGFNGVSVSTDLQGTILQISAFHPKHGIVLAEPYEQFDGTKFRDTPYVREYRSRMLRSMKNGVPGFGLRFEGEVQELQVDLDGLGRATVSYRTNGGLAITVFLRVGEDGEVVQSAEIRSLADSACRVSFTMDCGISVNRASYGQLTEGGPIPIPRSENKFNTIRYRQGFVITNTPLGAHLRGWLEGDGKLVDTQHTSQEETFVNSPVVKKYTGFLEIPPRGTRVISARFILQPGVVPHAHRDTECPQRVGLPKLWKTREEAGRFIVRRNLEYILGNCAIPVPQSRQAVRFLIDTYLNLKNLTYPSNAEEYAQVIKATVKGHLIWIFRYAQRPHKFWHRSYLTTGRPKDGPVFQLDQQCYPLLELCDVCETFPEERELVEEILRSDAVSQVLDLIETKRDARTGLFPTDETPGDDAVEHPFHFSSHVLLWHSLSRLAKVAAQFMAESAFEARLATLAMAVRTSTLDHFLCPEPASGKPTFSYLVDGAGQQTFYHDANDLPTLFAPSWGFTKTDSENQAWHNTMHFAFSTANEDGYYAGGAFEGLGSVHTRNPWTLGYFQQWRYSQMSGDRQAEAIAWDKICGVMLWDGMFSEAVDGHSGEVTSKAWFSWPGSMIGSGLLEKGNRERYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1T9</accession>
    <name>A0A1C1D1T9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1T9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03179"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="118" mass="12547" checksum="6BCFE54B1112C39F" modified="2016-11-02" version="1">MAQRPHGNNGWVARPGSSTASKAFLAGSKSLLKWTAPQEGRDAHLAGGVRRRQRVHGKVVSLFSGVKASCAQFPVGRPVVVGAPDGYEEGAKGACWVGERRTKLSLRRTDTPSKVHGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1Z6</accession>
    <name>A0A1C1D1Z6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ALG5</name>
        <name evidence="16" type="ORF">CLCR_02930</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1Z6"/>
    <dbReference type="STRING" id="86049.A0A1C1D1Z6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02930"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04811"/>
    <dbReference type="eggNOG" id="KOG2977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="15">
        <location>
            <begin position="204"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT54710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="447" mass="49995" checksum="C1724474C3D8F5EA" modified="2016-11-02" version="1">MVNEVVPPMASSGLDRPIGMGGHFMNIFRDDEWLNWRMVPFILIWAAFAVVLVVWLFMYFFVPEPRKPRPSEKTYTTVDKTGDVTDPEPLPCWYDDLLRRYYRARRDRPDRTMDMEKDFEPEPAEVFLTLVIPAFNEEDRLSGMLEEAVNFLQTEYGGGRDSSSSTAMQDIPEHSPARADIDAAGARHRKQANGVTSTSNSGHLSGWEILLIDDGSTDHTLLTAQTFARAHILPPHPRRDSGPWTHRSPQGVKIPPGSIRMVSLEENRGKGGAVTHGMRHARGQYVLFADADGASKFSDLTKLLAACRGIEDANGRGIAVGSRAHLVGSEAVVKRSRLRNFLMHAFHLLLWLLTPPATARIKDTQCGFKLFSRPTLPFIIPHMHMEGWIFDVEMLMLAEGAGIPVAEVPVGWREVVGSKLNVVKDSIGMAWGLAILRICWGTGIYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D239</accession>
    <name>A0A1C1D239_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hsp70 nucleotide exchange factor FES1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Hsp70 nucleotide exchange factor fes1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fes1</name>
        <name evidence="10" type="ORF">CLCR_03131</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FES1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D239"/>
    <dbReference type="STRING" id="86049.A0A1C1D239"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03131"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04858"/>
    <dbReference type="eggNOG" id="KOG2160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000434">
        <property type="entry name" value="Hsp70 nucleotide exchange factor fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="9">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT54764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="207" mass="22621" checksum="1BD1C4B61D481D0F" modified="2016-11-02" version="1">MDKGLNSLLSWGIENSDASRNPDQPIQEPKGLSEEVLRSLMGGPSDADLMKEAMAIITSSDPDITHDSKMTAFDNFEQLVEQIDNANNMEPLGLWTPLLDQLSSASADLRRMAAWCVGTAVQNNAKAQERLLALNGIEKLVQVSLDDADKATRKKAVYALSSAIRNYQPAMNEAVKRLPKDIVGPDHVSATDMDVIDAIMGKLRDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2B7</accession>
    <name>A0A1C1D2B7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2B7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11445"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04993"/>
    <dbReference type="OrthoDB" id="4148141at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="262" mass="29808" checksum="E4770AC95C14EDE3" modified="2016-11-02" version="1">MVERKLFILESYYQRGSNEQKWRIVNSEGLSWREDIDQYTFVKPSICRIGVVVEVTRVQSLLQSSGDTWDFLGVLSKGPKLDILKNDGERYRKAILEKVSSQQHLCSHCGMPCTHNSPPQRVRFADESSVHINTVQKARLWGRVFAVSAKKGHELWLLSGQVRQHGYSWLLMKDVILSLCRSTEDFTLSKIMYTATDDVCLMWKVPAAGMKFVSTDTRSPRIVTLTSGVLEETNPDIGSYFTLHILGNAVRNGIPKLRSNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2D9</accession>
    <name>A0A1C1D2D9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2D9"/>
    <dbReference type="STRING" id="86049.A0A1C1D2D9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02966"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05061"/>
    <dbReference type="eggNOG" id="ENOG502S0PE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="449382at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="242"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="438" mass="47430" checksum="A8B584315BBF37FF" modified="2016-11-02" version="1">MAQSPNNPTTIDPADNDAAQPDHPYQPYMDTKPPPNAGLSDANGMPLTEREIESLEKQARAERETTPEPKDFNIAFPDNLPTPPFLHVDGVPNFRDLGGYQCLAPTTVATGGGDASSNTAAAGGKTYVLKRNLLYRCAHPTHLTPQGLTYLTETLNVHDMYDLRSAPEISRLAATVSSSGKAVYPLADPHTGCLLDSLPGLTRHFVPVYQTEDYGPVALARKLQWYTAEQSFDPAHDFAYSEGFVRAYRDIATHGAGAYRVMFRHLLRQPQPPSPLVFHCTAGKDRTGVFGALVMKLVGVDEETICWEYALTEPGLGAWRKEFIERISQTGLGGGGGKAQTQTQNGDAAAAAASSRPAISRDEAARICGSRAGNMRAFLRTVLDGEFGGIHAYLTDRCGLTAEEVQRLRDALIEEVPTQEVLGRVEIEGWTAEGGCVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2G4</accession>
    <name>A0A1C1D2G4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2G4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03036"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05016"/>
    <dbReference type="OrthoDB" id="4140498at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="323" mass="34582" checksum="A75B6CE1E7362DDA" modified="2016-11-02" version="1">MAKEFASKSFSGGVDSRKSSRASRARPWMANSILRRQSAATGVKGCEGAPSLPKATTVTLGSDPAPPVTVERVAVKQSASKIPILVRRCGSASLGKGGMQEKAKSTAMPSTVTGMATSASRIPVRTKVPSVGPRLVPQQVRTNNALGAAAGLPVAKEVGNKRGTGGSAAAISRPKPEPEEMSIQKCINPAPIRSHRSDIAVRSILKHRAKPSEENDPHCPLDSRGNGVKFNPAEKKGVTWPEVYAIPTPPRPWHKEAVPAWECRLCRGCGHRDWCPSLIGVTLGPQAIDVWLREQRARGYDYLEHSGGFLSSRDHDPTEPVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2R3</accession>
    <name>A0A1C1D2R3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Brl1/Brr6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2R3"/>
    <dbReference type="STRING" id="86049.A0A1C1D2R3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02942"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05155"/>
    <dbReference type="eggNOG" id="KOG4503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="3">
        <location>
            <begin position="232"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT55062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="444" mass="49960" checksum="34BA18A33B5C5147" modified="2016-11-02" version="1">MAFRGTESPMDFEWQGHGPVDPTSPFHRRMIDMQAKKRTHTDFMSPQKTSFPALREPNNQPFFFSDAPASSPQPAAFRTPSFTTPRKPFDIDFSSPPDNSSPLGQTDNDETPDAKPLPPLPIEFTSSPAKPEKKRSSLSGLFGKFAASPGRGEIRKPNSDAIARRVHKKRRRAQKFDRSLILSRHGSLDESDDESTPSPTEPTPRRKAVEEVGWITGLFTFIHTYPDAPSIIAKYLQVFFNAAILSGCLYMFWSFYATIQADVDRASEDTMAEVLAEMAQCSKNYIENRCGADTRLPALEVVCSNWELCMNRDPSAVKRARLSAHTFAEIFNSFVEPISLKTMIFTITFVVVGLVVNNATFSLYRRQQESHYAAMYRPPSASYMHPQHPGPFPLPPSTPLTQPRYVGWQGDGGFGGQQQLEYSRSPSKEHRSRSRSPEKKRIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2X8</accession>
    <name>A0A1C1D2X8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000001">
        <property type="protein sequence ID" value="OCT55132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2X8"/>
    <dbReference type="STRING" id="86049.A0A1C1D2X8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00008"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00017"/>
    <dbReference type="eggNOG" id="KOG4341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="174"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT55132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="740" mass="83149" checksum="1AA74B10A57B739B" modified="2016-11-02" version="1">MDQAVPPNMASTNSFAAPRPSSRPVTPASPMMEAQTPFDPPVKLKGRHRLLQGLQRMSSSPSLAKLGRTRSSDKVYQSKQKASISCVSLNSPPSTYSLSPLNSYALSNGFSTAPTTPGSPGSQQSYFEANARFRPLGPNEITSVSVPNDIRTSKPLSTPLPEISEKPFPRRPNFNFWQDMPHELRIYILSFLSPKDVIRASSVSKEFHDMCFDGQLWTSLDCQTYYQQITSEALIKIMLKAGAFVKNLNLRGCVQLRDQWLSLGTRMTNQECRNLEHFSIEGCKIERSSIHFFLLRNPRLLHINMPSMQNINNATVKIIACHCPQLELLNIDWCSQIDTKGLKKVIQSCPNLTDLRASEVRGLDDNDFMLELFQRNTLERLILQSCDSLTDEALEIMIHGIDPERDVLTDRPLVPPRRLRHLDISRCRSLTDRGVKALAYNVPYLEGFRTCQNTALTDDALEALLQSVPRLTHLEVEEVEQLTNATPITLSKSKAAKTLEHLSISYCEQVGDIGVLPLLKACPELKSLCLDNTRISDLVLMEASEQVRKRGSTTKKSQRPKKGLELVAFDCANVTWAGVREILQGNGRVMQGRKKSVVQTYGIEDEYGETKELRKVVEIQTLLYPTEIIHLKAFYGWQQTVEEHYKRCATGRWGAAARLEQKWAEWMVASEEVGVVGHGWSSRRRRRRAREAEYRVRDDEDGAAQEAATGDEGLSEGEFVAGRAPRGGRRRARSGGCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C662</accession>
    <name>A0A1C1C662_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid:diacylglycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">plh1</name>
        <name evidence="3" type="ORF">CLCR_00092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C662"/>
    <dbReference type="STRING" id="86049.A0A1C1C662"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00092"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02044"/>
    <dbReference type="eggNOG" id="KOG2369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046027">
        <property type="term" value="F:phospholipid:diacylglycerol acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="639" mass="71994" checksum="D42F48D4D9C72EAA" modified="2016-11-02" version="1">MSTLRHRIVNILRDSPTPSPNPSRDATPDPNEEVSVVSTKKLEKLTKRRHSKRRSGLTFGLGGLLGLMLALLLAQSQDIVKLEGLLEVNLDSLMDAIPVGIINDVKDLSKAERDVVNYDSFSVGLHLQAQGIQAHHPVIMVPGVISTGLESWSTAEKSRPYFRKRLWGSWSMIRALIMDQTLWKKHIMLDKETGLDPPDIKLRAAQGFDATDFFITGYWIWNKILENLATIGYDSTLMSTAAYDWRLSYGNLEVRDQYFTRLKNYIELAHLTSGEKVVLISHSMGSQVLFYFMKWVEHKDHGKGGPHWVNTHIDSWINISGCMLGTAKDIPAVLSGEMKDTAQLNSFAVYGLEKFLSKEDRAEIFRAMPGISSMLPKGGEAVWGNSTWAPDDLPPPLQNKTHGSFISFRPRGNSTQAMRPNLTMTEAFDHLMNVSEPWYVETVKHSYSHGVAHTKQEVEQNEHRPTTWLNPLEARLPYAPDMKIYCFYGIGKPTERSYFYREKEFSLTGYINISIDTSVTTPNGRFQDPGSIDHGVALGEGDGTVNLISTGYMCAKGWRQIKRYNPSNIKITTFEMPHEPDRFSPRGGPNTGDHVDILGRSSLNDLILRVAGGKGAQIEDNYESRIWEISDKVQIYNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6N6</accession>
    <name>A0A1C1C6N6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GND2</name>
        <name evidence="16" type="ORF">CLCR_00605</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6N6"/>
    <dbReference type="STRING" id="86049.A0A1C1C6N6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00605"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01065"/>
    <dbReference type="eggNOG" id="KOG2653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 14" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="197"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="28"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="51"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="93"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="147"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="204"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT44129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="506" mass="55568" checksum="998A5F5BF31E7DAE" modified="2016-11-02" version="1">MSGPVARLAGLKVGPAQSEPSGDFGLIGLAVMGQNLILNAADHGFTVVAFNRTVSKVDRFLENEAKGKSIVGAHSIEEFVSKLKKPRRMMLLVMAGPAVDDFIEKLLPFCEKGDIIIDGGNSHYPDSNRRTRYLADKGIRFVGTGVSGGEEGARYGPSLMPGGNEEAWPYIKDIFQSIAAKSDGEPCCDWVGDEGAGHYVKMVHNGIEYGDMQLICEAYDIMKRGLGMSYAEMGEEFAKWNNGVLDSFLIEITRDVLRFNDDDGKPLVEKILDSAGQKGTGKWTAINALDLGMPVTLIGEAVFARCLSSIKEERTRAEKVLSGPKPTFTGDRAAFLKNLEQGLYASKIISYAQGFMLMQTAAKQYGWKLNKPSIALMWRGGCIIRSVFLKDITAAYRAEPDLENLLFNDFFNKAIHQAQEGWRDVVAYAVKAGIPMPAFSTALAFFDGYRTKDLPANLLQAQRDYFGAHTFVIKPEYANEKYKTGDHIHVNWTGRGGNVSASTYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7F9</accession>
    <name>A0A1C1C7F9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ethionine resistance-conferring protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ERC1</name>
        <name evidence="8" type="ORF">CLCR_05601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7F9"/>
    <dbReference type="STRING" id="86049.A0A1C1C7F9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05601"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07126"/>
    <dbReference type="eggNOG" id="KOG1347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="660" mass="71191" checksum="69E666A07A78FF53" modified="2016-11-02" version="1">MTTPPKNLSTLERVTSVTSRAFSRSLPDFSPIAQASLARDIEEDPEDAVESESEPDSETSTLRPSTSAPGRGQSSAGLYRRPSFVGAGNRATVLPHLLSTEHERLSKQERKQALEEERSLLRDNNIIPPKHPQAAGGDASRKRSIFHIPGGDRKVSRDEEATPALDGGLGVASEATPLLGDPTLPYGGQDDPETINQKWEEAVAAGMIHTTWQREAKVIARYAAPLMVTFILQYSLTVASIFTVGHIGTVELGAVSLASMSANITGYAIYQGLATSLDTLCAQAYGSGRRKLVGLQMQRMIYFLWTITLPIAIIWIFAENILVAIVPEPEVAKLAGLYLKVVLAGAPGYAAFEAGKRYVQAQGLFSASLYVLLFCAPFNAFMNWLFVWRFKMGFVGAPIAVAITDNLLPIGLFIYVRFFSKTGMSCWNGFTKKALQNWGPMVKLALPGVVMIEAEVLAFEILTFAASYFGTTTLAAQSVLATLTSLTFQIPFPLSIAGSTRVANLIGATLADAAKVSTKVTFSAAVIVGILNVTLLSALKDYIPRLFTSDAEVIRIVSDILPLCAAFQLFDALAAACNGILRGLGRQEFGGYVQLFCYYVFAMPISFGTAFGAGWGLWGLWTGVALALGLVAAVEFVYLARTDWNRSVEEATARNMEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9G2</accession>
    <name>A0A1C1C9G2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9G2"/>
    <dbReference type="STRING" id="86049.A0A1C1C9G2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05668"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07766"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10045710at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="513"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="614" mass="66240" checksum="7929448382C9C161" modified="2016-11-02" version="1">MSEKQARRPPVAPKPSFIRQQHNVAAAGVSPLPSPALQGASLAFRPAPLKPSVPNPSASHNPSASAGALLAATAASTRKQQQQQQQQQQKPQQPQQHAALPLPLPQEASLSARGRALTTERLPVAVEGPSSLSPPKPESRPHAPRSTSAVAAVAASAKTSPVRRPELKKDQGSYLARRDPSQSRGRGMSTSSNSEPLQSLPQSAAALAGAKASMTTAPPQVQTATGDKQRKDRSYLSHLALPPAQSSSAPSPSASASGTTAAVTATRNAASLEARKRALSTSQESSPGAPGARYLSTSPQTHSGSSAPRVKVTPPLTDSESDNGRSVPDWPRKALPAPVPVHVQRAAITAREAAHATGHNTPTQDPRPTMTASALADAMVAGSLAVSHTGSRGASPAPKKVPPPVPRRRSQSVGAFQSGKHLMHMPGMRSDAGSRTPKLKPLPAKPMRQTLRSSPERDEPYDEKKRGRKHWRRHPNMHHEGDRRRWRDKITERERKRYEGVWAANRGLLLDYDLDNVEHEHRRDGTPASDLVVNVVVRDIWERSRLPKDVLEEIWDLVAQPDVKTLNREEFVVGLWLIDQRLKGRKLPVKVSQSVWSSVRHTQGVKISSKALQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9G5</accession>
    <name>A0A1C1C9G5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp70 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9G5"/>
    <dbReference type="STRING" id="86049.A0A1C1C9G5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05448"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09517"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749:SF8">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G13740)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="660"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="845" mass="94112" checksum="4EC8B271DE1A3B79" modified="2016-11-02" version="1">MPAAISNTLEPIFRQISHVPQIVPLANTHAMNNTATETRESPPGARAEVDGEQRGLTPQWHPESVDSRFIVGIDFGTTYSTVAYARVAAGTDVSGLGPNDIRCVDNYEDAAGSRDARMNARYDNVPTELLYFSPSYSDSETSESESTPRGNGFEQDFESPPGSPRIRSGRPGRERKRRVRQQIWTRQGSIEWGYRVHHIQKHRHEIRSKNDVEIVRLIKLILGNEGADESSGAGCVQSNRLRDAQQELLNQILRRNEGLTANSHIDYVLCVPVSWSPAASQTMHNAMASAVRKSGFGTLFGDAIIADLFIVSEPEAAAQFVLASLGEKGRLRQNQICTLLDAGGGTVDITTYKVTSDGNSPLRLQGEMIPADGALCGSSLINEAYKKKLLAKLCSTDFNGGADELNNVVAGLVADFEVSLKPYIDFTKKKTLPRRLYIPGLRANPEKKFSKHCLKFSEQEIFELFEDCLDGVSRLLESQLDRAAKKGLTVIDVVVVGGFGESPALRERMEQVVACRTNIMGGKIGLIWPDKFPTSTVARGAVLRSLNKETGPSRISRASYGFLRTEPYKDCPEHVQAGVMPSVDKVDGFEYVKNTILWVIQKDDELDARFESKPIISSHTFGTKEPKLVCVECLYTSPKRHRLHFQRDHAENKGPSNLPFFFFFFFFFFSFFFFFFFFSFFSFFSFFSFFSFFSFSFFSFSFSFFSFFSFSFSFSFSSSFALASIPLNTASRSTPPSSILLVFTKAVPHVADQPAGAILLGKIEIDMTEFRNQLPTKENAYADTAAKMAKRRSIDVTFDLVIIVEGVQLMYQARWPSVSQPHLGDVRKTKTGYISLAPGFAPGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9I0</accession>
    <name>A0A1C1C9I0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-1,3-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_11216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9I0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11216"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07770"/>
    <dbReference type="eggNOG" id="ENOG502SVG3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5410040at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40020">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40020:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25089" checksum="37FB13AB34718799" modified="2016-11-02" version="1">MPPHLHPRSTATSTLFAGTLLASFIVVGIPHVFPCPRPRTGYAADAGRIEFDEDGKPIRRKATSTVTCASGAADGDLEARKATRQQRPRAPQRALSQTKDLDEEAALFRELAAEAEMLEKQAKSARECPVPKPRGWVGRILGFEDQRAAGKDSVWNKARQSPYAEPLTVDATTNIAQKSCKKPRSTVREKAGQGWMAPDEPVAGLQRALSDAVNLRKSRGDYTRGEQNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA09</accession>
    <name>A0A1C1CA09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_05722</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA09"/>
    <dbReference type="STRING" id="86049.A0A1C1CA09"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05722"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07950"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT45309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="508" mass="57966" checksum="25CA6EC24504740E" modified="2016-11-02" version="1">MSSLVVALGCICAFYVYHAINVARKRRDDMQMHVAHGCQAPPRLLNQRPLGLDRLEQIFRADSESRLMELFLFHFRLWGTTLEQVFLGSQAFGTIEPANLEAILSTQFEDWGMGPRRKVMFPFFGDGIFTQEGADWKHSREMLRPQFVYKQYEDLEVFREPVDNLLEALPANGVVNLQPFFFRLTLDVTTAFLFGESVRSLEKLESAGESDFASAFNTAQDFIAKRMRLQDLYWLVGGSKFRQACHDVHRFADQIIDRNLSRDLGCDKGQKKYVFLDFLARNTPDRKALRSQIINILVAGRDTTACLISWTFFLLVRHPRVMDKLRSEIASTLDGKAEVTRSDLRRMNYLQNVLKETLRLYPSVPVNSRTALRTTVLPVGGGPDLRSPVLVPKGTSVAYSVYSMHRRPDFYGMDAELFRPERWEEQMALDDDPTNSKWGYLPFNGGPRTCLGMDFGLAEAAYAVVRLIQRYPTIRLPPGEKVELVGVEKQTMTLVVSITEGCKVEVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA13</accession>
    <name>A0A1C1CA13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA13"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06252"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08011"/>
    <dbReference type="OrthoDB" id="4146226at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="246" mass="27273" checksum="D953FBF1BD7ECD6E" modified="2016-11-02" version="1">MVLFDPADTALAAVVRSINATTPAWRLGPLNASWVFVTDSIPPGSDVNGHNYSDSHSDIGGAIVVQRKVANSVGSLSLNSFVYLMVSAFVIIVLIPLPNRKYIAGLLLGEDTRFHTDCPRSATGISEFTFERMIRGFYPPEPRHAPLPSYLEALDYVPGREVRSGDVRECQSMIRRVYLLRVKVYNAGNVHPANLGIVDGWRAQAEAGLSDIRTLADNWAQRHDWSPEERMKVAQIRQRIMAIQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB47</accession>
    <name>A0A1C1CB47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_01483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB47"/>
    <dbReference type="STRING" id="86049.A0A1C1CB47"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01483"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03586"/>
    <dbReference type="eggNOG" id="ENOG502RXSB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4132249at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="591"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="620" mass="68479" checksum="B4AE6F34FF779B68" modified="2016-11-02" version="1">MAAAPVKKACDACHRRKVKCSGDQPCNNCAQTNLQCTYLAIPQKKGPKGSRGKVISGIRSTQQDTNPPTTSASAVPSFEKEPSFDFSSPPKSPPNAQNISLLSRQTIENCIDFYFSNMSTTAWILHCGALKHAIASRLMTDPELYCLTGSICAFVMVQPGMNLAVAPGSYYEGEPPENRYGYANMILNDIIRTRKSINYVESPTLASVQTAFFLFSCYFTLEEQNVCWFYLREAATLAHLMGLHEESSYLLNDPVDSRYRRRMYWLLLVTERAYAMERHRPLTLHPTIELPTTHDQQEEEMISGFSYLISLFSCIDDEFMALWNKVKTDCSATWLSRLQQQLKDALPNELETTESQIADVRVTMNWLRIMVWQLSITNGYLSSSSNDSSMTFKYPIEVARDLVRELQDLSLDAMEVHGIGLIEKLFDIACTLTDVIACVPFDVSTNETPFDTLNKLLNLISRLRGGASRYLPLLLTKVSETLPSIAQPAPVNLNPSQLSITQGYAGATDNLPTPAPAQYSSLGSFGPEGFTFGSQYALNQNQEQAPQHDRSPAGLMFDGYSPSVVGTKATSNLTPGTLGTPPAGYLGFVGQINPPQSLHPTPRSVPVATEPSTQHDGYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBP3</accession>
    <name>A0A1C1CBP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000018">
        <property type="protein sequence ID" value="OCT45896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00067"/>
    <dbReference type="OrthoDB" id="4147332at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650712" evidence="1">
        <location>
            <begin position="20"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="116" mass="12293" checksum="1C724057BA521250" modified="2016-11-02" version="1">MKASVAITAALASASVAMAGLVPKSELTPNIPMKIGCYPTGNNPAPNAMSIKLPTCNGDLNGDNCLRFCKCNEKSEVVCDSDDMKGCSDKEMSKVCGQTGEDADWHGYFYCSCWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBP8</accession>
    <name>A0A1C1CBP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBP8"/>
    <dbReference type="STRING" id="86049.A0A1C1CBP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00372"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10061"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="673" mass="74986" checksum="395A834FB78E4733" modified="2016-11-02" version="1">MYHFVFETPQPSAAPSSAEDRRRAELQDSDARSHAAKMAYLKKLARQHVTQQQQQQQRRKQFRCVHSTGRDGNEDEDDNDEEGADNVAAVIRRNTINKRPDGSPPSPSPSPSPSSSAEHQDEQDDSSGSSNAELRPGGGRFSAPTIKSTRRQSCSCSYSYLSPGATKPKKGNRIYSRAKFRVEQPRSLLAQTSKDPFDAFPQRRLPENVEKVVQYAFDRIWPEMLCAVRGETLAIAKSEWKGHGLHDELLFHVQVALACGLNLALQTVPGVSEALALTRLSHYSTAIRLLKRRIESLEDGDGGASEDLMMSMLILGVNADVEPAMPEAHPPSPLATSQYMHLYGRLTLMPSYATALHQLVEARGGIFKLRHLALADWLLLADLHHASRTGDRLRYPPIRAYYSIVASAKHVLDAKAELLSHKLGLGFRVLDDALFTADLRDAVAKGVEATVALDHYHRYENRPPRLVDVMLAANEAQRTFLNVFPNRGVGLQQLVHEACRLGMLIFSDMVLFPMPSCTRIKPRLAAELRRVFETLESQGNPEVMHEARCACSSPRIADLILWALTLGGIAASFTDDRSWFEGRLRRRLRLRERERVREGGGNSDVDSDAGAEPEIEAWPLPPPSSSWPAFKDCVSTFLWWDPVVDEPARDLWEAAMRVAGADVDVPEAKNQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBS6</accession>
    <name>A0A1C1CBS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Interferon-induced GTP-binding protein Mx</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_00380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBS6"/>
    <dbReference type="STRING" id="86049.A0A1C1CBS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00380"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10086"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF149">
        <property type="entry name" value="GTPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="45"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="616"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="734"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="742"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT45917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="819" mass="91953" checksum="68D1731A38DE7E04" modified="2016-11-02" version="1">MAPDNSRETNHSDKATTPLVQLQSKDHEEILNVIDQLRSEGISKYINLPQLIVCGDQSSGKSSVLEAISGLAFPTKDNVCTRFATELILRRAPETSVTASIHPDDERTSAEKERIQQFKSSTIDLHQFAAIIRDAEICIGEGRDGHIFSKDVLRVEVSGPTQPHLTLVDLPGLYHAPDESQTAEGVEFVESLVLSYIQNKRSVILAVISAKSDIALQKVTAFTRKVDPNGHRTMGIITKPDTLSKGSDMEQSFLNLAGNKRVEFRLGWHVLKNRKYEERHFSLTKRRDSEAEFLASGVWAALPRSQVGIESLRPRLSAILKDHIIAQLPGLITETQQSLEETDASLQRLGDARQTLADQRRYLLHSSERFSGLVGYAINGVYFDPFFGDAMDDEGYQRRLRAVVQNRLSDFSKNLEAKGMQKQIIDDEDEDMVLEEGQIFRSAYMDEVQQRMRRSRGRELPGTFDPHIVGDLFYLQSKPWESNVMECIDMLLKDVQKAIKPIIEDILDDKTITGLLEYILNPGLDKVEASLRDKTKELLKPQQSGHPITYNNSFIESVQRARQGHHQRSIREKLREFFGNSYPRFPSSETSFVFSMDNLINALGTQTEDDMERFACSEAIDCMQAYYEVLSPSCICCRSGREDADAVNFTNQVARTKFVDDFSNLAVEKCLLGPLAVIFCPKVVDTLADGVVENIAAEDESSKLERARLLHKRVKLQDSLLQLHRLDRHNVTGAKGRLHLDDEGDNDNDNDSDSPADGLESIDGPASPAESLMLATSGEAYEAGPDREPATELEPEFAEPPKSGKKKKHKNARFWESIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBT4</accession>
    <name>A0A1C1CBT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative mRNA-splicing protein ubp10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ubp10</name>
        <name evidence="14" type="ORF">CLCR_00421</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBT4"/>
    <dbReference type="STRING" id="86049.A0A1C1CBT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00421"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10080"/>
    <dbReference type="eggNOG" id="KOG2026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000068">
        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="13">
        <location>
            <begin position="87"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="209"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT45922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="576" mass="65368" checksum="D0D5ED92A7A9AAB1" modified="2016-11-02" version="1">MSKRKSEEPLEGAFAETSPASKRARIEDVPEEVPTANSDQDTRLRSNGAEEAEGVANGRQEDEVESDVEDYRIPAAPLRQSAPTEGYDDLYLDTINRSLLDFDFEKLCSVTLSNINVYACLVCGKYFQGRGPQSQAYQHALELDHHVFINMETKRVYVLPEGYEVKNKSLDDIKYVVDPKYTAEEVKMLDKDPKESTDLANKRYRPGFIGMNNIKANDYLNVVVQTLAHITPLRDFFLLHQFPLTAAQLPVRFSTLVRKLWNPRAFRSHVSPHELLQEIALRSSKRFTLTQQSDPVELLTWVLNNLHSMLGGSRKALSSPIHRCFQGRLRMESQEITAKADTTGDRLRFEESSNIKTDVHPYLILTLDLPPVPLFRDAVESKNIIPQVPLTTLLQKYNGLNAMERAAHRVRHRLLHPLPPYLLFHVKRFSKNKFVAERNPTIVTFPSPRGLDMSPYVEPNPSVHPPGEPILYDMVANIILDTTSVATTGGEDTNAADAANMAVGAEGLRVAWKVQLRDKAAAYSQRSDLPEWLEIQDLWVQRAESETLFTREGYLMVWERRRESKKGKQSNGVKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC94</accession>
    <name>A0A1C1CC94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">THO complex subunit Tho1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC94"/>
    <dbReference type="STRING" id="86049.A0A1C1CC94"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00393"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10341"/>
    <dbReference type="eggNOG" id="KOG2491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257415at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="79565" checksum="88C0D2399D94F8D3" modified="2016-11-02" version="1">MAVTDVPSVATYKDLIDSCLQQLSDGREDGDIDSAVFETECAQLLSQILAIRKDATSDTLQIHNAAVETVCREIVWDIVASVDISEPAFAQVWVLLDVINILSDNELCEPGLGFWLVEELLDSQTIEGCRKVFDYLESRREKMTAKHFKQKNLVILRCCNELLRRLSRAEDTVFCGRVFIFLFQSFPLGDKSSVNLRGEFHVENVTAFDPTPVKSEDAIKPMELDNATPQAATSGAHTPASQAQDAEKTARSTPIPRVAKTEPKDQQPPPDLDALYPRFWSLQSFFSAPTRLFEPSNMTAFKDGITQTLSCFKSVSSSSTASTTSPSDVKRGLKRKRSNVDTSSSTSTFNPKYLTNRDLFDLEIHDIAFRRHILVQALIMIDFLLSLSSTSKAKFEGLTNKSVLYPYTLSDDDAKWAQSTRSQIATYLQQGGNGNEGKFYYRMVDTVLSRDKNWVRWKAENCPPITREGVSPEMYLQARDTLTKQIEVARAPLVNPPGANDLAFLSKVEPLEALKNPSKRYKVPTAEEYYRGIETDELDMDFATTEEEKRDIEERKAGKVWRALRSSKNRFVMCEKVQYGGDCKPLIEEVKTEEHEEHGEKGAEGEGEDEVKDKLQGLGNGIRAEIKVEGEGEVEGHAQVAAPEKIEAPPLPPPPSTEVDEPREQPGKDLDTVTKVEDAEMTDIPPASMPADTVDVKDAPEATVDGDRDPGETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCB4</accession>
    <name>A0A1C1CCB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_01113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCB4"/>
    <dbReference type="STRING" id="86049.A0A1C1CCB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01113"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09396"/>
    <dbReference type="eggNOG" id="ENOG502RHAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT46118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="565" mass="63957" checksum="286F440452E2660B" modified="2016-11-02" version="1">MSGPLALSTEARPQKKRRAAIACTACHARKVRCNVVLVGQPCSNCQQDQALCLLHVTARGKHKRRRVNREEEEEGHGSPVLSAATAVAQHRVATSTDVQGCDESLSLDSDLSSQDEYESQANVEAYRKIVDGTDTKGARVPIYVGELQSLRFIFHVAREDKGISCKAHYLVPEPKRRNLSPEEFACLEAKGAFSAETDDLRDQLLNLFFDYVYPILPIIDPYDFYRRYDTGGAANISPLLLQSMFLAASNFVSRDAIKKSGWSSVMTMKRRFYERAKALYDVEYETDKLCLIQSVLLLGYWLGNSHDRMDSWHWVGVATSLSQSLGLHRDAGCSRIPQCHRSLWRRIWWCCFYRDRCIALGMGRAYRINTADCDVKDLTLEDLVCSGMGPTDLKDTSAAIVRRCSSYAPIFLEIIKASRLLGDVLASVYRPRRDDDSLDSSSWNTAQSVEEKLAAWQLGLDPRCRVDSPAFSVNEPRAMILHKYYIQILHHVTVITLYKPFVFQDDMLPTDPASDIRARLAWEGCQLSASAATDSFRRLTELDLIRFLPPERQVSDIRARFTPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCV7</accession>
    <name>A0A1C1CCV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_01223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCV7"/>
    <dbReference type="STRING" id="86049.A0A1C1CCV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01223"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650715" evidence="4">
        <location>
            <begin position="19"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="321" mass="34758" checksum="82B53A79271FE92B" modified="2016-11-02" version="1">MLYQCLLALCFLTASSLAAQTKKTCYSLDGQELDGRFQPCNPDAEFSSCCALDGTDGENDICMDSGLCMSTSGWFSTYLWANGCTDPTGKAKACPQQCNFMPSGYSFNVLQCDANNGSFCCRSGSDEDNCCTTESRVFQAATTIGQILLPGTDQVVNTTYSTILPNSSKDHSRVVGGVVGGVLGAALIASLIALFMLLRSRKALRNDYSSLQQDRDTLLQQGFNEKAALQQELEQQRLAYQQYHMAQAPTYTPAQQYPAAYYQASAALPMPMGTDSRGYPTEVSGLARPVEMDTMRGASELSDETASQKVERTEVSPNKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDC5</accession>
    <name>A0A1C1CDC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA mismatch repair protein MLH3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDC5"/>
    <dbReference type="STRING" id="86049.A0A1C1CDC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01850"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01191"/>
    <dbReference type="eggNOG" id="KOG1977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="2">
        <location>
            <begin position="496"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="751" mass="83952" checksum="E84277DD8EF156BD" modified="2016-11-02" version="1">MCKEEVGLIRQGTNAVVHNLFGDVPVRLKQLSLRYSSAPETERAFERVKKMLVGYLLASPRSVEMRFTLRGEKQRSLRCSSSQMGSTPFSLESTVSILFQSKFLGTLDTKQWRSASVRTSHFSIRAAISTHPAPSKAAQFISVGQVPIWRGQGANFLFETIDRLFEASNFGALDDERTVTGNRSGRPDRNQPTTEVSKLGKGVDRWPMFYLRIDSKLEHISWLMGQDELSAEAIPVTDHLTKALESLISHFLTSSGFAHHAKPGDVSRSRAGIKHKDDPVDHLQSKLPVSELSRNATEARYLSYWNRVKSAWPSEENFRYGLGLDGTVEGVRSPADILEADRSPVEARCQECEAGIGLHNTQVANAEGADSTTDLVWTNPRTGQMIHLNPRTGAIAPAAGPQGDGRLEERYGHSSRVRKFPNPRSGRTMPQPRPPAETLQKYSRTTGAQRPEAPITSIAREECPALRGEQLGPGPATIAIPSSQAVTRRALSAAKVIQQVDQKFVLAAVSAPTKHTEGFGSGLLVLIDQHAADERIKFEQLCQEFCKRTSTTLSRPLSFEVNETEVRLLEEQRAHLQKWCLSYNLNKVPRDSTDTCKRSVWIVEVTALPSLLAERCRVDPKLLIDLMRREIWSDRLRLDSSTAHAVDQTEQNWWSDLARCPPGMIQMLKSRSCRTAIMFNDVLEPDQSRELVRKLAHCSFPFQCAHGRPTLTVVADFQDIESLIPAISAHTRIRDFAVGYGDVWRRWVDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDI7</accession>
    <name>A0A1C1CDI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_02025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDI7"/>
    <dbReference type="STRING" id="86049.A0A1C1CDI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02025"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01319"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF81">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="9">
        <location>
            <begin position="9"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="183"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT46590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="329" mass="35156" checksum="65A2C63743704982" modified="2016-11-02" version="1">MDLSKISGLGFVGLGAMGLPMAGHLATKLPENVHIYVYDINQASMDQLHQDYPNRITKCSGAKEVADKSEVILTMLPEGKHVRLVYMEGGSETICSSDVSGKLLIDCSTIDTASSLAVKDYINEKFPTTSFYDAPVSGGVVGAQKGTIAFFLGCDGNDANLPQVTRLLQLMGKEVIPCGGPSKGLAAKLSNNYLSGIIAIAVSEAMDMGMRSGLDPRVLHKVYGAGTAQNTICDRFCPVPGVYPEAPSSRGYTNGFKVQLMRKDFGLALDMAKRVGAKNVLGEAGYATYDGASNDPRCKDLDSRVVFRYLGGNEDWQKDADEATASKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDK1</accession>
    <name>A0A1C1CDK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01986"/>
    <dbReference type="OrthoDB" id="10487876at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="417" mass="46104" checksum="BA57063E6A86A8BD" modified="2016-11-02" version="1">MSLLPYWLGLRPMTYTSYVKIRGGGNRKSPTPSTYLDESGESESSGSTMEVYCSQTIEGPGEASHSGCAQALEDLDTPPVDLFEEPNPHVVRRDLYIQAARQNRIRVEGLRDQAVLKAKEAIEQPMVTGSQAVPQRPSNVKKSRNKGRTKQRSQETHDPAFSPHPLDPPLPRGALDEQQQHARQARGLQVPPSLSKSCPLGGRRQARQHERRRVMTHARDRGHHRSFASPASTTPPATKPSTPDPIASVRAHDASSPSVTGGPLSLSFSRTPLTRGIYGTRHTDQSTSSFPTSPLRPPRPHLPPQGPSSSPPRNSHMDTAESEEHDVRGRRSQAPSPTPQHQQLPEAGRLPQQQKEKKAEQASAETKVMNDPDLEDICWEVNFLRTVVMRWLGIDSSHYRGWLEDEARHSNQGGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE11</accession>
    <name>A0A1C1CE11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01883"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01485"/>
    <dbReference type="OrthoDB" id="4154938at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="569" mass="63766" checksum="8526D63725FCE548" modified="2016-11-02" version="1">MTPLINYNQSTFKDHPKPNKRRLQELQHSAARAHAARVAYWRKRGVPIAESRSSEQSQDDGISDASTDSAIHVKQERDGGAQRLSHQTSCAPEDSKQGTPAPSARDVSQEHLYSPRSVSDSALATSNPTFTPTTYRWRLNSGTTLSGRGQTPGRWEGRLFIPGLTRLPVSNLFDPFDAIPIAQDAKVVAAMDHYINKWAPSQRPGLKYQTKDNPLIRDAFPAALQNVELFEAAVALCLSFQAASQNFEARMCNWSLYHKGQALSRIRNKLNSGWLDEAVILATVFLMIIDDGKSLQDRKYQRAVWGLSVVVHSMVRGQALERALLQKLIWIRIQRAESNALLLFGDRISLHGTVVKDACLGYPSHPFPSTLTTVIGTLTPGFKALASDGQLSVEVLSSLAKTVRWTRCIDPEPGQSPSGNDQAFLMTFDPRANSADLMRLCRISGEEYAVERAVCKAVYVYHANLLGWTCRCSGYRRVVEELGTALRSWDFHKTWDRDLWKWLALVTANAARRGKLQHLQAELMTRLFASGSSEQDWKSVQLATKKFLFHRTLGREWEMCWDMAHASIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE41</accession>
    <name>A0A1C1CE41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">arc1</name>
        <name evidence="9" type="ORF">CLCR_01987</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE41"/>
    <dbReference type="STRING" id="86049.A0A1C1CE41"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01987"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01516"/>
    <dbReference type="eggNOG" id="KOG1523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT46800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="395" mass="43450" checksum="8D6CC63D3C41ECCF" modified="2016-11-02" version="1">MSGPEVHHLFHHPIADHSFSADRQTLAVARENNVELYHRSGNKFNLQDELKGHDKTVTGVDIAPGSGMIVTCSQGKQSKRESTSRNICTPNPPPSEVPASYLSPNENRNAYVWHPTPQGWTPTLVLLRINRAATFVRWSPSEKKFAVGSGARVIAVCYFEEENDWWVSKHLKKPIRSTITTLAWHPNSVLLAAGSTDSHARVFSGFIKGVDERPEPSVWGERLPFNTVCGEYLNDSAGWIHAVSFSPSGDALAFAGHDSSITVVYPAGPEQAPRAMLNISTQILPFTSLIWNGEAEIIAAGYDCEAFRFRGSEQGWEMVGSVEAKARPGMGAMREESALNMFRQMDLKGKVKDDTQLSTTHQNTINTIRVYEGGAAGVRKFSTSGVDGRVVIWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE74</accession>
    <name>A0A1C1CE74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_01978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE74"/>
    <dbReference type="STRING" id="86049.A0A1C1CE74"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01978"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01461"/>
    <dbReference type="eggNOG" id="KOG0259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="66"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="410" mass="44664" checksum="BD9BB130ADCBAFC7" modified="2016-11-02" version="1">MTAAAELELLEWAEKYLPSTKHDLFSSGTTNISISDLLEISEDRRGSEKHLSLNTLKLEESVSSSRYTELRKNLAALYSARSGGVTADDILITNGGSAADYTVLSALLAQGDHVICQHPVDELLFKIPAYLGAEVTNWNAEPATKWRPDIDELKTLIRDNTKLIIIQSPCDPTGAIIPRPVLEALMEMAEEKGILIMANETYRPLFHSISPSDDDFPPSTINLGYRKVVVTGTVAKAYSLGGTRAGWIATKDRSIMASCRKTRRLKSTSASILDELIAAEALSDRCIHALLARNIKLCQTNLGLVQAFVDEHSWACSWVKPQAGTTAMLKFHKMGKPVDSEGFCLKLLEQAGILLCPVGRCFGDSQTVRGYVRVAFGASTKDVSAALAAWKAFIEEAFESVPTAPSKSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEF8</accession>
    <name>A0A1C1CEF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEF8"/>
    <dbReference type="STRING" id="86049.A0A1C1CEF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02659"/>
    <dbReference type="OrthoDB" id="3527108at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="159" mass="17977" checksum="9C6429F5F558D1D2" modified="2016-11-02" version="1">MSRRGARSAPGTRSSPTTQRIVTRIPRVVLNGLTKDDVRTGRIFDLPDAITDPEHKFSPPSPSPSPSASGNEQPGSQRYHALVAELETLERQKPETHRNSWQDATEGGMNEPWTYDPKGFQKMWWAMADKGRDMYKLKWGTQECSLDEHGVKLGDVWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEI9</accession>
    <name>A0A1C1CEI9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEI9"/>
    <dbReference type="STRING" id="86049.A0A1C1CEI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02565"/>
    <dbReference type="OrthoDB" id="3527108at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="230" mass="25785" checksum="77677D6E95C57E49" modified="2016-11-02" version="1">MQGPGPPRRWTTGTMGKKSMHHTPYGPPWGWPLPKRWLFVLLLGIFGILTILSGLSRDQTPRPTTRQDSTPLSETSPSTSPYLLGPDEDGTKLWFPPPWTETPFQPSAASDNLPPAISERPRTPLFIAFTRNIAMLQQTVLSYIAAGWPREDIIVVDNRHDGCELVGTPHLAKSVLPRLRTCAPGGMVSRSCRPPTLLSFAQLMNFYLRISMAHGWRYLLLVSYGCRHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGD5</accession>
    <name>A0A1C1CGD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGD5"/>
    <dbReference type="STRING" id="86049.A0A1C1CGD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03738"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01872"/>
    <dbReference type="eggNOG" id="ENOG502SQ0A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3923202at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="146" mass="15355" checksum="34C9B1C006464322" modified="2016-11-02" version="1">MVAAQVCPIVGTTNTVLPPKHPDFDLDKPGQVCPVTKATTDHHHNLSKHPGVFDSSSDLSNADNCPALTKIVSQPEQQAMDEAICPVVGTVSSVLPPNHPSTKEAKEGDVCPVTNARFEHHKGKIHEHPSLDAAAKGAVCPVVGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGY1</accession>
    <name>A0A1C1CGY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03780"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="73" mass="7943" checksum="53FB4D191C708336" modified="2016-11-02" version="1">MASSEGVMMVIPFSPTLKNLDGSTGFRELTAAAMVLESNENEEAKQKQEVDMIDHAADISARERPALVLTVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGY6</accession>
    <name>A0A1C1CGY6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit B</shortName>
            <ecNumber evidence="7">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_03406</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGY6"/>
    <dbReference type="STRING" id="86049.A0A1C1CGY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03406"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04575"/>
    <dbReference type="eggNOG" id="KOG2438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1722066at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Asn/Gln amidotransferase" evidence="8">
        <location>
            <begin position="422"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="577" mass="64577" checksum="357B74E20E0C8E33" modified="2016-11-02" version="1">MHGRCLAWTRQRFPVRPFTGLRPFHSCRPWLRTDRAPLRKQLKDAAKAARATPAALPRTTRHDTPDDWELTVGIEIHAQLNASRKLFSPAITAPSAVPNSQIAPFDIALPGSLPVLQPGVVLPALRAALALRCTVEPVSSFDRKHYFYHDQPAGYQITQYYHPFAKNGHVVLNAEDGLEEGRTLTVNIKQVQLEQDTARTQEDDANTALIDFNRCGQALVEIISLPDLHSPCDAALYVRKIQSILYAVDSVTTGMEQGGLRADVNVSVRRRDAAAGPYVYSGVTGLGQRTEIKNLSTFKGIEDAIKAERDRQIKILEQGGVVQGETRGWSMTTPNETRRLRGKEGEVDYRYMPDADIAPLYLSNDLISWVKKTLPPTESDLVHLLVNDYDLTFTDASTLVSLDDGERLIFFQEVVDELIASSKFETTTRDHGKLVGNWVLHELGALLSSDGRHWDDNVVTSRTMADLIYRLKANEITGVSAKLILKLIYNGDKRSVSGIIIQEDLRFSEMSSESYEEIAKDIIGKYPQHVNDIVEKGKIGKLQFLMGQMMRHPRKGDMRAPIAEETLRRLILKESEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH26</accession>
    <name>A0A1C1CH26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_03379</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH26"/>
    <dbReference type="STRING" id="86049.A0A1C1CH26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03379"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04539"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015565">
        <property type="term" value="F:threonine efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032973">
        <property type="term" value="P:amino acid export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010509">
        <property type="term" value="P:intracellular polyamine homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF5">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="108"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="567" mass="62682" checksum="7CA97A9A850B6AE3" modified="2016-11-02" version="1">MSFDNVEKLPASEDILCRTSSNEKVGKEDDAEGGSDTRSIHSQRSGQSTVADAHDVENADDVLARTVTPKKPIVKVSRAERRGLFARFSLTAEVTDPYDYKDSTKWVITFVVAIAAAAAPVGSAIILPTLDDVANSLHTDPTTTNLSVALYMLSMAIFPLWWSTFSETAGRRTVYLTSFTMFIVFSVLSAISHSISMLIAVRLFAGGAAASVQAVGAGTIADIWESRERGRAMGIFYLGPLCGPLLAPIVGGILGQAWNWRATQWALVIYGVLTWLLVFFGLPETLQATKDVVADTATDTAPSTTDSDRPPLSRTSTREVIQKRSRKYLTVARMLLVDPLSVILYLRFMPVLLTVYYSAVTFGSLYVLNISIQYTFERQPYDYATIIIGLLYLPNSFGYILASLIGGRWMDWIMKREAIKANRVDERGKLIFRPEDRMRENAWLGALMYPCALIWYGWTVQKGVFWLAPIIANFFYGFGSMIIFAMSTTMLTEFMPRRSSSGVALNNLCRNILSCVGAVVGAPLIAAIGNGWLFTILGVWALSSASVIWAMKRYGPGWREHMDRQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH49</accession>
    <name>A0A1C1CH49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter STL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">STL1</name>
        <name evidence="11" type="ORF">CLCR_03367</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH49"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03367"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04550"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="20"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="510"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT47796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="545" mass="60430" checksum="593BEFDC0C80549F" modified="2016-11-02" version="1">MKLFSKRYLGLSGTKLNIAIGIIAGIDFLLFGYDQGVMGGLLTLKQFTAVFPEIDTTAEGVRGLTPSQANHRSTIQGISIASYNLGCFCGAVACIWIGDLLGRRKTIFVGSATMIVGAVLQASAFSLPHFIVGRIITGMGNGLNTSTVPTWQSECSKSHRRGQLVMVEGALITGGICISQASWRFPIAFQIVFALIILAFILELPESPRWLILKGQEEEALQVLATLSDKSTDDKYIRSEFAAIKDTVLEQEKATFRDLFTMDENRHFHRVVLAYANQVMQQISGINLITYYAATIYQNEIGLSGFISRILAACNGTEYFLASWIAVFIIEKVGRRKLMIFGAIGQSASMIILAVMTKIGGTGPGWVAAVFLFIFNSFFAIGWLDPDYFAGMTWLYPAEIVPLKIRAPSNALSTSANWIFNFMVVMITPVSFSSIKWKTYLIFAVINAAMIPVVYFFYPETAMRSLEEMDGIFHKTKNIFTVVWTAKHEPHRYGKHGEVLIDYEETGEHERRMSHAERRGSVMSRGSATEYGSEKVVGAAKEDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH72</accession>
    <name>A0A1C1CH72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH72"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03713"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="114" mass="12433" checksum="9376E4C1F142E292" modified="2016-11-02" version="1">MVTLCLVGRIPLRGESAMSVDPQVDTHYGVQPRSIFLLGRPASCKLEITLLTHITPYPTHQDQAATPRPKTLGKGGSYPSRLSDTPALGNSSTWLVASWPRCLVEEYLAQDDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHF7</accession>
    <name>A0A1C1CHF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHF7"/>
    <dbReference type="STRING" id="86049.A0A1C1CHF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03818"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08132"/>
    <dbReference type="eggNOG" id="ENOG502SPHS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5423516at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="674"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="960"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1167" mass="126452" checksum="0E594E1FB7A6AA09" modified="2016-11-02" version="1">MPALKDLVCHVQWADTGSPYPEYGTVYGDGLVETYIAVPAHPQVFTIRLTSRKFIHEGLSMVVFIDGQYQCNRNRVNLQPEKKDVPENRSKVDFLLRQKEKPLGDGTYMGREWRFDDCNLVSQMPEEAEKSHFCYLGTIEVLVMRCRSRHYHERALSASSSGEHSALLDEEEGSDNTASAGEADDADKKAGLEKQSTKAETPAATVEEAIPGFFGLFDGPADEPPAWHSSGDAPADNHYDYWHRHNGLPARYGPQEGSRGQPVYRAHHTPYEEARPSRYPYHDSSPPDVYARHDSPASRSERHVHFDQGDERGPRYGGYSDRYGPHHHPVFERNDRREYTRTRPRSYHDPSRDGEHNLYPDYSTVHERGPFPYALGHPELQQAYSSYRHRAPPPSHPESHAYDHLPSHPAPHAYAHPPFTFPHLNVPPHQTLHHGQHIYGPPPFATSQAPNAAAATSSGPPVPLPKIPMQHARLPQAPHPPVPCVAPPSLAPNVFVPPIPGPFAVHPPPPGIQPLFHTQGPNVDGGHAETTSAPDGLSGQPNNAGNHGQGGDPSRESESKTSGSIRYDEVSDQHPPAKNDNNDSWGDSGADNNSGDNLGNWANTAGNNDSNGTDNPSSTKCPANNQTDTGASNDNNNQDTDWENKNNDDASNNNNDSSFGQNQGDGWGNKDDSGGNSDVNNNVGDSNNNQGWDNRDSENQQGSNDNNWANDIQNNQNSGGDTGWDNNQNSNPTKQDQANSWGNERNNNPPPGNQAVKPRDGQNNMSGSHAQPAPGNCHTASRVLYGPYGPYYGAKSRAQQGPPPDAEEEPRYDLPQAIAQTRGVTKQVQPGPGYLYVKKRCAPLYIDSLDEPYAKFVFKYRTREQLKNEIGVDIAGEPSGDEEVNALEILDKTELIQLLLRAKGALGGTIPEPPTLPTPSAMNGFERVTVPAPDVSFLHYSLPPARHGSNNVGLGIRHLSSNNRSNGGGPSQINNNNNSNGGVGRGQENNRQDANDWNNNNTNNAAANNSGWDGAQERKPCPTTPQPPIATRQSQEPVQQGDNLHPPQDASRRSSSGISPKNMHGVPPGPTLDDYNRLLSGAGAVSGAPPIMSGPRPPPPPPIINFGAEGTVGGGQTDWANAPNMGAGPRPPTPTVPPRPPTPINEGEGAAWGGGGDTTAVQPQSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHU5</accession>
    <name>A0A1C1CHU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase UcpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ucpA</name>
        <name evidence="5" type="ORF">CLCR_04253</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHU5"/>
    <dbReference type="STRING" id="86049.A0A1C1CHU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04253"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08247"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF37">
        <property type="entry name" value="CLAVALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT48095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="306" mass="34192" checksum="E10786D0FCCAD6EB" modified="2016-11-02" version="1">MGSLEQPQPHTPARPHTGERFTPTIHHDTYPAIDVSNSVGVIGKHVFLTGASRGIGKAMAIAYAKAGASIIGISARSEMEGVKREIEDEAVSAGHEMPTVVTVNMDVLDPDSVRQAIEQVTPEFQGRVDILISNAGYMEPWTKIVDNDVDEWWRSWDINIRGQYLLWKAMIPLMLANESSLKTIVNVSSIAAHVCSPGASAYQTTKFALLRLTDFLNVEYGDQGLIAYCMHPGSVPTELSWKMPDFVKVNLIDTPELMADSVVYLTQKRREWLRGRYVSCNWDMPELLAMQDEIVEKDKLKMRMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI42</accession>
    <name>A0A1C1CI42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI42"/>
    <dbReference type="STRING" id="86049.A0A1C1CI42"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03949"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08329"/>
    <dbReference type="eggNOG" id="ENOG502QXAC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF273">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN SAMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="74856" checksum="F35CE5085992E43E" modified="2016-11-02" version="1">MGGQVQGDCSALPAYLQTILDQLPDDHSVALSYLHGPSVAEIEKITDRRRRFAYLLLARHRLTERLAICPGPCPELILKRAEVYEALGYSELALADAYVSYTLSLVALDGPDISDLVPVDSDGEPWPSNGPEQEEHESTAVALRHKYWSLVIMCRSAIILGVQIQAKLWIDEILAVKRAIRGLKGDETTDKAKDIDEVTEDFCKYSTVYEDESKFRKCVGILRQENHKPTVFGWCQRQVYPWNEHEPERMSKEALKEINDKLHEAAPDLEVEISTLPTLTPSLELGVQRLSVGEKEPSVSTHANCSSQLGLFAKKQLAPGATILKERSVLTGIRPHGEALCDACAADLEGVDQADRRYCTGCHIPFCSEHCQSAATQRYHHPNVDDYETDEGYPPAEAPFCAGTNGNDDIHNIGRAESSTTPEWDLYFLLLSRTMQMSETQKLHPLDLFETKYLWGDFSPMPNVGDLSIKSGPKTLPYSVRHHVELPLQWFEILMHSRDRCRPYSAAWLKKYDWWIVQTLFAKFRGVADAQQSTWTGKPEVAAVHPLWCLANHSCNPNVTWKPSGVRNLTVVKERVWERPDKPSILPWEGIRAGEEIWNHYTDVQEKDHRERQGRLQAVLGGDCRCERCTYEARRHAATRLGESARHHANTSSRSIGGSRSSVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIT0</accession>
    <name>A0A1C1CIT0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIT0"/>
    <dbReference type="STRING" id="86049.A0A1C1CIT0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04438"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08500"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="119" mass="13078" checksum="C65933A4F4FBF589" modified="2016-11-02" version="1">MSGSGAYSEHPTIHARHLWSRQVGPGQVLITSRAAPSTNRGLPSLTPRSTILAGYLKFLDDPSLNGKIIEASRDQLFFQEKPPYADGDYSKRSSTVFDPLFEMVHGQPSGLEDIVRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIU4</accession>
    <name>A0A1C1CIU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Catabolite repression protein creC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">creC</name>
        <name evidence="8" type="ORF">CLCR_03888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with creB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat creC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIU4"/>
    <dbReference type="STRING" id="86049.A0A1C1CIU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03888"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08557"/>
    <dbReference type="eggNOG" id="KOG2394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="422"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="673" mass="74529" checksum="3A67D515FE2F4F27" modified="2016-11-02" version="1">MFAIPPPPRYPTSSGLVTTTLETANTLTTREGPEYTFQAGEGTYVLRDDLQLATPPPHPSEVPVINPNPLSTSVAPPTSGVKLSLVSLNPKQINTDLYRTTTATSSLLRWRSLGLNNSKESKEPKKVEEVKEVKEIEKEPRISVESGSDTSNPAASQNGSNKSSTARPFGEGNAALSPLMTRDGLKRRKPKNNIIKSNSSFVSRVIPHESLAKKLQERDQGGTFAFVNINRAFQWLDLSSSSKQDPMTKILFTKAHMLCHDINSLTKHSTHMDIVMGSSASDIIWYEPMSQKYARINKNGMINSSAVSTIKWIPGSENLFLAAHMDGTLIVYDKEKEDAPFVSEELIDEAISIEDEDQSTLVISKSVNSSNQKSNPVACWKISNQTITDFAFCPDSKHLAVVGDDGFLRIIDYPQERLTDLFSSYYGGFTCVCWSPDGKYVLTGGQDDLVTIWSLPERQIIARCHGHDSWVTAVAFDPWRCDERTYRFGSVGDDCKLLLWDFSVGMLHRPKGVTARTRGSISTQSMSLLRQRTESASVVNRLRSDSNRTGSFVQAEIVDESEFLNHPVEPRARTALLPPVMSKKIDDHPLSGLAFEQDCIITSCNEDRPVGKGKALNRDPSVATLLYQITMVACFEAMPGRRWEHTIRSSSALDGARTIKKPLSWESVYGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIU8</accession>
    <name>A0A1C1CIU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11294"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="247" mass="26304" checksum="1EBE4A6FD9939AAA" modified="2016-11-02" version="1">MKRFLGLGPQQPAKTQPRLQVHVRHEVSESVDPPGFAPNPAAAPVQPAPAQSQERPGDRGAQNSARLPTVLALRQGTPDVGPSTSSAPSGSTRKAPPPRAPIVAKAPGFEEPWNDSDAGPLSPPQGPPPNKSATAPRRDPASDRVLDIRALPGSNPLLPNRNKPLPEPDIDADLDDGPPAGPPRLPPDREKSLPPPPRASQEIPDDLFSGVLPRLPSTTESRARAAGRRPEPVYYKKPTDRLQSDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIW8</accession>
    <name>A0A1C1CIW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_03816</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIW8"/>
    <dbReference type="STRING" id="86049.A0A1C1CIW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03816"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08533"/>
    <dbReference type="eggNOG" id="KOG0941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="866"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="575"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1227" mass="138009" checksum="3787B81E24B3141A" modified="2016-11-02" version="1">MASLPSSASHHHHSSRPRPRNLQLTRSASHDQPPPAADLNRPLPPPPPPPPATAAADTYEIPTLRRKPVPNEPPDAGAAKLNHSRSFSHPFPSIFGSRKTEKKNKHGGDLDGTRDARHEEAGNKHTAAEGSSSRDDRQPVTGRCMTCDSTVRWPQGLKVFRCTTCLTINDLEFNPEKRPDARAPAPQRKILPVSVERTRSLLDRCLMQYLESRVGRDEPPTPARPIPAENDTPADDSFLMEGSPPEGILYNQLTDEQDSPPPSPRPRINLRSPSEESTLSTHHSSRNAAPAFVQGQSVDPFSSTTSPPIRHRDARAHQLSETGPTTSSNSGPRWDIFYLVEDYIASCFVGCAVLNHSFLTPRPPQEPNLKPRSSSGTRQRRQLSDNISAPSFDNDVFLSELDAKTLLLGDVAENGSWWLGAPSGRVATGKDVTHQRDKSPDKNRSSASARHHRINWLELAEWYRLIIYAGDLWEQRWHELLPKLSDARAQQYWRSTPVESLQRDIIESRIHLQRSLLKVSENLLKRPRQPLKHPEDCRFLLILLANPLLTPARLEAGMMFGTTMPHPPIPAARLQVEGRTRDSPSKRIPSSGRRPGSLGHHSGIIKRILGLMANLSNENHQCLVSWFSRYADGHFQRTVEMVGGFVTYRLSRQQKNPVHEPVNPTEGLVPSFSDSGMHHASQIHAALGGYRPASTATGKTQEKPKLTAYGEDWQIRVAARVMALLFQANVGHVARKRDASAAHEQRLHSPGLNAKYRAYLHGQIVPISNFYNTMLDYADLVADFETWENTKTKFTFCQYPFFLSIYAKIHILEHDARRQMEVKAREAFFDSILSRRAVSQYLILKVRRDCLVEDSLRGVSEVVGSGGSEIKKGLRIDFQGEEGVDAGGLRKEWFLLLTREIFDPYHGLFVYDDDSQYCYFNPFCFESSEQFFLVGVLLGLAIYNSTILDVAFPPFVFKKMLASAPSTGDKLTSTPKVAHGYALEDLAEFRPVLAKGFRQLLEFEGDVEATFCRDFVAEMDRYGEIVQVPLCPGGEKRAVTNSNRREFVDLYVHYLLDTAVARQYEPFKRGFFTVCGGNALSLFRPEEIELLVRGSDEPLDIASLRAVATYEGWPKAEGPPEQQPQVIWFWEFFARVSPADQRKILSFITASDRIPAMGATNLVIRIQLIREKEEFDLFGTPANKPSERFPIARTCFNTLSLYRYASRQKLEEKLWTAVQCSEGFGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJA8</accession>
    <name>A0A1C1CJA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJA8"/>
    <dbReference type="STRING" id="86049.A0A1C1CJA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04274"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10250"/>
    <dbReference type="eggNOG" id="ENOG502RZMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF4">
        <property type="entry name" value="7ALPHA-CEPHEM-METHOXYLASE P8 CHAIN RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34354" checksum="F0619D80E610B341" modified="2016-11-02" version="1">MTAATFKYIDPASYVKSDVPFVKPWGKVDGPGYSFKLTDRERSVEDIRGREREYNIDNAGFAVYKSPAQEKAFTDDAKVREGYYAEVEALLRQKLPGVKKVVFFDHTIRRREKASPRQPVQQVHVDQTPRAAEIRVRRHLPAEEAEDLLKGRYQIVNIWRPIAHPASDFPLAVVDYRSTKPEDLVKVDLLYPKRNASNGTTDDDDRGKEVLPDPSSATSTEGYEVKGETFAVQPSENHKFLYMKDMTPEEVMFIKCFDSFSEVNGGKKGIAAYTPHTAFVDPQTPADAPGRQSIEVRALIFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJD6</accession>
    <name>A0A1C1CJD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJD6"/>
    <dbReference type="STRING" id="86049.A0A1C1CJD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05055"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03259"/>
    <dbReference type="eggNOG" id="ENOG502SIN0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF11">
        <property type="entry name" value="ZINC-CONTAINING ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="307" mass="32070" checksum="A92618D66E077163" modified="2016-11-02" version="1">MRAITVSSWGAAPAFTSSHPDPSSSEDTITLRVLASGLHQLVRAQAAGTHYSTKTTTMPYIPGADGVGETADGKRVYFNSIAMGGGFAESIAVPKQSVTPIPEGADPVVIAGLTNPGMSSWMAFAGRVDPELPKGFTVVIMGVTAISAKVAVQFARAKGAGKIVGVARNAKEMAAIADLDERIVLATNPGETDFSSLADVDLILDYLYGPAVVALLNQLKSSVPTQFVQIGTVAGNDVALPGAVLRSKNITIRGAGPGAWAMSQFAKELPDLLDAVAKLPDMELTVRKLEEVDAAWGHKKERTVFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJG9</accession>
    <name>A0A1C1CJG9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="1">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_04569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJG9"/>
    <dbReference type="STRING" id="86049.A0A1C1CJG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04569"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03233"/>
    <dbReference type="eggNOG" id="KOG2161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14419at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="4">
        <location>
            <begin position="316"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="3">
        <location>
            <begin position="593"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="805"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="816"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT48660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="920" mass="106647" checksum="279017CEA39CF97E" modified="2016-11-02" version="1">MKYLYKLPQKKFPYEQLIQENAKRGKLEREFNIVDSDAFKDNRYFDIFIETAKETDDPEELLFRVTAYNRGPEPAPLHIIPHMWFRNTWSWGHEPEKLKPNIRMVGPMTAQSKHHKLGHRFFQLSPSPGCGPDADDVHPQLMFTENDTNLDKLYGVKNKQPYVKDAFHRWIVDEEKGAINPRCSGTKCAAWYDFGQGDGVPPGECAVVRFRLSRKFDGYLNEELVDDIIELRRQEADEFYYRISPLPMADDLRNIQRQAFAGMLWCKQHYYFIWDQWANGDPNMPPPPEGRKNIRNQHWKHMYLDDILSMPDSWEYPFFAAWDSAFHCIPLAMIDPDFAKKQLDLFTREWYMHPNGQLPAYEWNFGDVNPPVHAWSVFRTFKIERKMYGRQDLDFLERVFQKLLLNFTWWVNRKDNDGKNVFEGGFLGLDNIGLFNRSEPLPTGGVLEQADSTGWMAFYCLCMLNMALELAKHRRTYEDIASKFFEHFLLISDAMSFRAGGKEQSLWNEEDGFYYDAISWGGPWTQQMRVRSLVGLIPLYAVLTLEPELINKFPNFKRRMDWFIQNRHDVAERNIASMRKRGKDERLLLSLVSKERLEQILKRMLDETEFLSEHGIRSLSKYHEDHPVSMDVNGQQFKVSYVPGDSDSGLFGGNSNWRGPVWIAVNFLLVESLLRFYMFYGTSLQIECPTGSGEYMHLGHVAEEIQHRLQHLMARDNEGRRAINAGNDILDFDPHWKDYLWFFEFFDGDTGRGLGASHQCGWTGLMAKMIHDTGINCRLPQTPRTPSTGLAHYFDDTFSSGLTRKNTFVGTPGPMRRSSTSRSLGGRSSFVSNGTNGDHSARGQATPAVIHDVDAATYFDAAASAVTDGDEWGKEDKLEKERRKSIADSHYEKFVNEQLTKIKTDESVGVYEDEFEAQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKC5</accession>
    <name>A0A1C1CKC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Hydantoinase/oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_04539</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04539"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02943"/>
    <dbReference type="eggNOG" id="ENOG502QQBE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5404895at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1610.10:FF:000001">
        <property type="entry name" value="Hydantoinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="entry name" value="CV3147-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048350">
        <property type="entry name" value="S-Me-THD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="S-Me-THD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="S-Me-THD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="S-Me-THD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF10">
        <property type="entry name" value="HYDANTOINASE_OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20906">
        <property type="entry name" value="S-Me-THD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="S-Me-THD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160991">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="203"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD N-terminal" evidence="4">
        <location>
            <begin position="607"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD-like C-terminal" evidence="5">
        <location>
            <begin position="769"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT48965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1008" mass="106488" checksum="1F470355CEC7F7A7" modified="2016-11-02" version="1">MYRIGVDVGGTNTDAAILDTNALESDSRGVLATCKTATTAHVTLGIQSAIKEVLAKSNVDRSKVLNVAIGTTHFVNAVVENDARRLSRVAVVRLCGPYTRKIPPFSDFPYALRNIIEGPIFYLDGGLEIDGREISSLKPDQIKEAASAIVAAGIQYVAVVGVFSALDQKCLHEERCKALLQQLEPSLSVACSGQIGGTGLLTRENATILNAAILGFARKTIMGFRLAMSKLDLSCPLYLTQNDGTLADATLAAELPVKTFASGPTNSLMGAAFLQRLGHGDRRLADKQVVVVDIGGTTTDICSLLPSGFPRQAPNFVEVGGVRTAFSMPEVLSIGLGGGSRVRVVGGDDGVVSVGPDSVAHRLTTDALIFGGSVLTATDVIVASGDARIGDSEKVKSVPRKVMEGAKSDIKRQLERAIDRMKVSSAPVSVLLVGGGSVILTDELDGVDECLRPPHHDSANAVGAAIAKVAGEIDIIEILAGRDENAAIEAAKKTAIDAAIANGADEKDVKIVDIQKIPLQYVNNKATRFVIKAVGSLKVKDGLSPDRSPNGTPSDEVEVDEDSSPEAAKAEGHNVKNGNLAKPTLGVDVASYRPDVRDGVWYISPVDVELIASGAGVLGTGGGGSPYLMALYTLDTLRKGGAGRMRVVALESLKDNDICVFGSGYGAPSVSNERIGDGTDVFAAIDAVNTIMGIKDFQGIVADEIGGGNGLVTFPTSARYDRPVVDCDLMGRAYPTLEHGTPYVYGQPVLPFATADCKGNSSVVLSAESNKRVEALIRQTCVEMGNSTAAAGRPLPGNVIKQYAVPNTVSQAWYLGRAVHLARQMKLDFIEAISTITPVRQLYTGKIIDVTRDVSRGYTVGRCIIAPLSVDEEVDIGPPPSSTSNGSQARETRYLAIPFQNEYLSAGFISPQTYHANPASSEEEEIICTVPDLISILGSDGEALGSPELRYGLKVRVIGMPAHPLWSGSAEALRVGGPEFFELKTEWKRVGEYSKPRSVIEEFDVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKI5</accession>
    <name>A0A1C1CKI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 7alpha-cephem-methoxylase P8 chain related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKI5"/>
    <dbReference type="STRING" id="86049.A0A1C1CKI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05072"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02905"/>
    <dbReference type="eggNOG" id="ENOG502RZMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="289" mass="32972" checksum="FC785140F113CDAB" modified="2016-11-02" version="1">MSATTTQTSVSTTLSGSQDSSYVPRGPVKTKLNFFKDPEDGSKPHNYVEKPPAGQPQRNFGETVVEVQMNDIRDRENEFWLDKDAFQAIKGIPSEETEFVDDEHIKKVYYPEVEKLLLEQVPGAHKVTIFDHTIRRSNPDAPRAPVTRVHVDQTARSTEWRVKLHNPEEADELLKGRYRIINVWRPINGTVQAHPLGFASADTVDDHDLVPVEHRYPHRTGETAAVRYNPKQTFYYWSGMDNDERLFLKCYDSKEGVGQRVPHTAFIDPRTPEGAKGRESIEVRALVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKQ9</accession>
    <name>A0A1C1CKQ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GrpB domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKQ9"/>
    <dbReference type="STRING" id="86049.A0A1C1CKQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05195"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02870"/>
    <dbReference type="eggNOG" id="ENOG502SEGQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="GRPB DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G01530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822:SF1">
        <property type="entry name" value="GRPB FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20696" checksum="0E36A0C91FA2328D" modified="2016-11-02" version="1">MRVVVEPYNPAWATQFQELKSELEETLRGVTYISIEHVGSTSVPGLAAKPTIDLSVISERQDIPAAIEALTTQGGYNYMGEMGIPDRHAFRKPGVAPTRNLYVSVKGCQSIRNQLGVRDLCRSDPIVRDAYGRRKLELSRQEWKNVDEYCEAKNDIIAWMLEKAGLGEEEREEIRQLNKVTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL88</accession>
    <name>A0A1C1CL88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LYR motif-containing protein 5B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lyrm5b</name>
        <name evidence="2" type="ORF">CLCR_05327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL88"/>
    <dbReference type="STRING" id="86049.A0A1C1CL88"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05327"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02690"/>
    <dbReference type="eggNOG" id="ENOG502S4S4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="63" mass="7841" checksum="EBE1C647892826A8" modified="2016-11-02" version="1">MGKHYPLGYDYFRPRLHKAFMSKAHLRNEDEIRQGIQRAEYVKKEIEALYFLKKYRLMKQRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLC1</accession>
    <name>A0A1C1CLC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Carbon catabolite repression protein B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Deubiquitinating enzyme creB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin thioesterase creB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-hydrolyzing enzyme creB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-specific-processing protease creB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">creB</name>
        <name evidence="17" type="ORF">CLCR_04611</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19 20">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with creA, creC and qutD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLC1"/>
    <dbReference type="STRING" id="86049.A0A1C1CLC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04611"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02638"/>
    <dbReference type="eggNOG" id="KOG1864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000075">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase creB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="USP" evidence="16">
        <location>
            <begin position="43"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="78"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="531"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="561"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="694"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT49303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="709" mass="79548" checksum="2312D69F6628EC6B" modified="2016-11-02" version="1">MTSFFGKLKSQNASAPAVGPATARKDASGPAPTPLERMLANAGPIRNDGSDKFLGMENVCLYYSVPFRENVLSYPRRSSPGSIAFSQKHAPPRQPPSQQNGAAKKPNGPASSRNAGTPPQQQKPEDKDSPEYKKKQALQAGPILNMTYDNSKDYDMPETLFTSLKDMFEAIVTAQYRTGVVSGWRLLEVLRQENEMFRSAMHQDAHEFLNLLLNTVLENLEAHDRKLIAQKKAEEPPPKKEEPTDMVRSESATVQFPSILPVPTASSPTRWLHQLFEGTLTSETRCLTCENVSQRDEPFLDLSVDLEQHSSVTACLRRFSEEEMLCERNKFHCDNCGGLQEAEKRMKIKRLPRILALHLKRFKYTEDFGRLQKLFHKVVYPYHLRLFNTTDDAEDPDRLYELYAVVVHIGGGPYHGHYVSIIKTQDRGWLLFDDEMVEPVDKNFVRNFFGDKAGLATAYVLFYQETTLEEVHKEQRTEGKRRASQDLTAGIGVDAKRSAELHRVETVSPLSSPNSSAEAAQYAALDHAMTAPPDFKANGHVEPPRSPTISAARPASPVVQSKKEKAKEEKARKAAEKQAEKDRQEAERLRRKDLANKITEAHKKQEADLKAALEASKQTKAEEDQRNALERAHTYQSNGGGSSGFEKFKRSKSLRFGSLTKKDKPPSNPSEENIVPPMPAGGGDTPEKDLPKEKKNRFSIRKKSFGMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLD1</accession>
    <name>A0A1C1CLD1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_05137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLD1"/>
    <dbReference type="STRING" id="86049.A0A1C1CLD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05137"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02620"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT49320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="242" mass="25680" checksum="8147F60CD1A228B3" modified="2016-11-02" version="1">MSYESFFASRVYAITGGASGIGLATARLLVQYGASVSIADIHVRTPEELFATDGGSGDDDDITPTTTTTTALSQRVRVHKVDVRSRQDVDAWIADTVRAFGRLDGAANLAGTIPRDHNVGGVEDMDDEQWRFVMDVNVYGVMNCMRAELGALGRKVATVNVPTAGEGEGKGETMNAPHDPAEATTTTTRDHFSIVNAGSGLSVRGREYTSAYTASKHAVLGLTRCAAKEVGKRGVRVNCIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLN1</accession>
    <name>A0A1C1CLN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CHS1</name>
        <name evidence="12" type="ORF">CLCR_04673</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLN1"/>
    <dbReference type="STRING" id="86049.A0A1C1CLN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04673"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03307"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="592"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT49389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="634" mass="70395" checksum="490A03F6AA7CB094" modified="2016-11-02" version="1">MASQASNARLVQAGSGLYKTGYNGSQNTLDLNSRMSVGASRSSLLLSGHETRYSVVMDSLGEAGAPVGFIHENVVPQPPPEWQPFGYPLAHCICLVTAYSEDAAGIRTTLDSIATTDYPNSHKAILVICDGLIKGAGNDITTPEIVLSMMGDWVVMPEDVQAFSYVAVSSGSKRHNMAKVYAGFYDYGRDSKIDPSKQQRVPMMVVVKCGTPEEALASKPGNRGKRDSQIILMSFLQKVMFDERMTELEYEMFNGLWKVTGMSPDFYETVLMVDADTKVYPDSLTHMISAMVKDPEIMGLCGETKIANKSESWVSKIQVFEYFISHHLSKSFESVFGGVTCLPGCFCMYRIKAPKGGQNYWVPILANPDIVEHYSENVVDTLHKKNLLLLGEDRYLSTLMLKTFPKRKQVFVPQAVCKTTVPNKFKVLLSQRRRWINSTVHNLMELVLVRDLCGTFCFSMQFVVFIELIGTLVLPAAITFTFYLVIISIVAKPVPVIPLVLLGLILGLPAVLIVLTAHSWSYVAWMGIYLLSLPIWNFVLPAYAYWKFDDFSWGETRKTAGETKKSGGHGEAEGEFDSSKITMRRWGDFEKERRAQASGAGWAQHPLAPPSRGGGAMTSDYASSQSGFEPYHDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM76</accession>
    <name>A0A1C1CM76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM76"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07003"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09811"/>
    <dbReference type="OrthoDB" id="4159670at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="549" mass="60443" checksum="4AA26680613FC994" modified="2016-11-02" version="1">MPKLSEPEREGDGPKQHVLNFTAFMMELLNRVHQVADDGDTFWEDRKRLLESDLTRLRQHWSELPPLPRSGLPAATLSAVAQHHVDVQLVLMILYCQILRTISRKTTISRRLQILRKSAAQTYYRDLLGSLRSTIDIFDYAYKLDARGTASSWPRCFGLFCAVLMLGIAKLRQDGDVDTDKERLETGLKIFRDLADTAGISGLAQSAAELLSGVLQGIEQLGQKASGAIGAASAPSAPVEGADTDIANVSPPSAPRLSPPARGERSGAPSLKRSKKSSLAEVPRRRKRARTGAGPVAFDLPQQTPTWAVGQDHSYPPAMSFDGAKSTPPQEPSASQGFETQPFPPSAASSFTEQAGYFEAELLPSHPDNMEEYHPGHHWVHPPMVYAPPLYDDWWQYQFQSGGNAALDGNLQPMSYNIHPPLALPPSTWTLENPSNYNGQVFGRDQQAEGLARRQSMPQLRILSPASDQHQQNRSLPPSRRPSQVEIETMAAKAAHNPAETPSSQSHYYEGTMTNEGLIEYHQTHIQSANLVTTGPYTGDGHGQHWGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMI6</accession>
    <name>A0A1C1CMI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetolactate synthase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ilvG3</name>
        <name evidence="8" type="ORF">CLCR_06844</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMI6"/>
    <dbReference type="STRING" id="86049.A0A1C1CMI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06844"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09897"/>
    <dbReference type="eggNOG" id="KOG1185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="7">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="5">
        <location>
            <begin position="225"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="6">
        <location>
            <begin position="441"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="608" mass="66403" checksum="3319FDFAC77C5135" modified="2016-11-02" version="1">MSLPTRLSPNDAPNLQNGDASPKPGWGSDYIAQQLAKVHIPYFVLVPGSSYRGLHDSLVNLNGNAAPEMVVCLHEEHSIAIAHGYAKVTEKPLACGLHANVGLMHASMAIFNAFIDRVPMVIFGAAGPFDTTKRRPWIDSTHTAVDQAALVRNYTKWDDQPASVNSAIRSVIKATAVASVKPCAPTYVVLDVGLQEAPYDEKDVRYPDTERYLTQQSAGASQADIKKVAQALRESKKALIMFGRMNRTQKSWDERIRLAEMFDAKVITDIKQPVAFPTTHRLHPAAPALFLAPEAASMIREADLIISFDWVDLVGFFTAAHGELIEPKAKVIEVSVDTQLHNGWSKDHFETPPADISIFADPDKFITDLVAELESAKLTGFPNSAWPATEPSSSQKPQNLDGEDIFQADLASALYATISPDDMCIIRLPLSFRGIDLLATHPLAYLGMDGGAGIGSGPGQAVGSALALKGTKYVPVAILGDGDFLMGNSAIWTAARYRIPVLIIVSNNGSFYNDEVHQERVANTRSRPVENKWIGMRLDDPLPDIGKMSESFGLKTLGAQISKRSELKGKFEEAVRLVRDEKQSLVLDVRVRPDDYLKNWGAGNVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMJ6</accession>
    <name>A0A1C1CMJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase subunit 4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_07476</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 5B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMJ6"/>
    <dbReference type="STRING" id="86049.A0A1C1CMJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07476"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09908"/>
    <dbReference type="eggNOG" id="KOG3352">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.11.10:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT49662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="195" mass="21856" checksum="6449A4D34453C184" modified="2016-11-02" version="1">MSVARTAFSLVRRVPFQAARVAPRTFTTVTARRASKYDPKPGDPEGKLLPFEEIKTEADLIPPGAARGTVPTDLEQATGLERLEILGKMQGIDIFDMSPLPSDRLGTFDDPITVKSAGNEYQVGCTGSPADSHNVKWLVLSRKRPFERCLECGSVYRMDYVGPPDQHDDHHGDHHHGFEEPKTMADFVKPEYWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CML9</accession>
    <name>A0A1C1CML9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Sin3-associated polypeptide Sap18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CML9"/>
    <dbReference type="STRING" id="86049.A0A1C1CML9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07544"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09937"/>
    <dbReference type="eggNOG" id="KOG3391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="250" mass="26521" checksum="E66B770CED9C4ACA" modified="2016-11-02" version="1">MSRSPSPPPKTTIDRQTTTPFLLNFCYRASAFHSLTDFPVPTPSNPHPHLPSHLQIYTWMSCTLQELALLLTQALPSILPDPAIGTRLSFRLVYPDLHASRGGGGRLESEGRGRYLSKEMGSVVVAAPESSNGDGPGAIRLQGEEADKTLEEARFVIGDFIDCAVFPPLSDGTVVSSGSVSARSGARGNGYGRVRGGGYGLSSRGSYNGFGPRGGDFGGPGTIPSGEWRRGERLPDPGGFRGGRGARRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMW8</accession>
    <name>A0A1C1CMW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07629"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08772"/>
    <dbReference type="OrthoDB" id="4117656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="197" mass="21558" checksum="E0325B97C2D60102" modified="2016-11-02" version="1">MADISPMDPNHPWVARGYRPEFAYSVKKAPVEDPHGEVAYQRAFVEAAEAKHSRAEARLCRVPDPLLYYNSPSARDYIKRRDDAIFSAKPRTGNTRTSTQPNTPSSIGTPTYSPGPRASPSYSANAGSATRRTSIKSDIEPALSIANSSPNIRTADQVSPRPSRPPAEQYQSYTPHGLPLTLEPKLDAPAGPSRMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN15</accession>
    <name>A0A1C1CN15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COP9 signalosome complex subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">csnG</name>
        <name evidence="3" type="ORF">CLCR_07394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN15"/>
    <dbReference type="STRING" id="86049.A0A1C1CN15"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07394"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08821"/>
    <dbReference type="eggNOG" id="KOG3250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0736">Signalosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="338" mass="36731" checksum="2A25C43D877BA715" modified="2016-11-02" version="1">MDQVQTKSLAAIQPIIYQITSSKNASPRFVAELIKGAISDRGAYIFTELLQLPTVQALRGTEFEPWLTLLEIFSWGTYEEYKGMSQGPTSRDQHRTKRLSAANPSLPQLDVHQTLKLRQLTLLTLASPFSPPTPDNTANNLTYAALLSHLQLSNPDELEGLITASIDGNLLTARLYPTSSPPSVHIISVAPLRDLRPQSLPTLLQILQTWESRCVSVVSDLESQIATIRATAQQRALREKKRQDLVDSLVLSTDKPSNDNGVGAGRAPRGAGQKLGSKRDLDQHIEGEDDDYEEEYEGMDLDEGLSESVGFPGGGTGSGSRGGGGSRGAKRNRGRGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNH3</accession>
    <name>A0A1C1CNH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07736"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08961"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12790" checksum="12F9ACDDFF2FC81E" modified="2016-11-02" version="1">MADQKMEAQKVEHVPVPEQFFQAEPAWSKYIPSGYLRSRCLKVSGMPMVVCILVLAGTYPLFFGYDAAVMSLVNINPDYLERMDSAGGTSHDAARIGGIVSFWFLGCLVGRDPTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPE7</accession>
    <name>A0A1C1CPE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_07009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPE7"/>
    <dbReference type="STRING" id="86049.A0A1C1CPE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07009"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05632"/>
    <dbReference type="eggNOG" id="KOG2641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT50365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="522" mass="59032" checksum="0A5C15BF87334ACA" modified="2016-11-02" version="1">MGWPKCNTTEEDMMITEDPLWDGHTFHTIGLWVGAIFTLIALLISFFLILMHATRYLKPWEQKHIIRILFMIPIYAAVSLLSFYYYRHSVYFEVIRDCYEAFAIASFFSLMCAYLAPDLHQQKIYFRTIKPKKWVWPMGYLQKITGGAEKGWLRNPRSGLTWFNYCFIRVFFTIVSVITQALDLYCLESLSPAFSHIWVMVFETVSITVAMYCLIQFYVQIKDDIRQHKPLLKITAIKLVIFLSFWQTIAISFLTSAGAIKANNTVQTPDIKVGIPALLLCIEMAFFAVFHIWSFSWKPYTIGSKEQMSEVVAGEGIATGSYQGGFLGLKALADSFNGWDMLKATGRSARWLFKGRKSRHTDSSYTLNRKDTDGSDFSAQGQTLNTFSSQPTYSGGGTKLPPYNRFGDEEDANLLANSQSMPTSQPPAFQTPGQYDSNNASDIGLATSSYDDKYNGRYDPPDGRPPPPQSYPSYQSSIGGQESGTVSIPYPDSRPGTQAHSHLGGQDSDRIYMARREVRMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ75</accession>
    <name>A0A1C1CQ75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_07325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ75"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ75"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07325"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05391"/>
    <dbReference type="eggNOG" id="KOG2975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000019">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="30"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT50623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="346" mass="37712" checksum="39A40023092E0848" modified="2016-11-02" version="1">MAEQDGFLHLSRPLGATAVGAQPTTAPLRVVIQPQALFSILDHCLRRPPDQQRVIGTLLGTRSDADESQVVVHSSFAVPHTETTDQVEVDMEYQKAMLALHLRANPKEVLVGWYATSSELNTFSALIQNHYSSQGEGTFPYPAVHVTVSSQAGQDVEVRTYISSPVGVSPERAADSAAFTPIPYTVNYGEADRAGLQAVETAKESESRTATILTDIENLEKSLEDTLGMLDRVAKYVENVIEEEAEPSTALGQFLLNTLALAPKVDPAEIEKDFNNHIQDVLTVSYLANMIRTQMDLSNRLATAQLTMGGGEGGQQGDNKDGRGDRRQNRQGGQQRQNRAESFSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQB9</accession>
    <name>A0A1C1CQB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07747"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05340"/>
    <dbReference type="OrthoDB" id="10373967at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650972" evidence="1">
        <location>
            <begin position="24"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="135" mass="14238" checksum="A5429432D4F86E17" modified="2016-11-02" version="1">MKIPTLCAALCTAILTGIGIADAAIVARLGFIPGRPGANCAQKDVTLYIDVNTSMVNRTTDILGPSGPSVQFGTVALEYLVPGCELLLCSQASSCDSDSAVHVYKPVCSVTYSDRVYWARYAVLCDGTEPMELEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQG7</accession>
    <name>A0A1C1CQG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-ascorbate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_06718</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQG7"/>
    <dbReference type="STRING" id="86049.A0A1C1CQG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06718"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05259"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13873">
        <property type="entry name" value="CuRO_2_AAO_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017762">
        <property type="entry name" value="Multicopper_oxidase_fun"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03390">
        <property type="entry name" value="ascorbOXfungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650977" evidence="5">
        <location>
            <begin position="19"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="34"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="161"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="417"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="618" mass="68322" checksum="D5BEBAAE86BF0CD2" modified="2016-11-02" version="1">MFLTILPILLLWLPLTIAIAPGPQALPDYVLVATAQDISINCQTRYSVVFNGTSPGPPGELHNMGESLQQDREWESYCGMDKHWHGLSQRTSPFSDGTPAVSQWPIAPNEFFDYSITPQIGDAGSFFYHSHVGFQSNTAQGVVIVEEAQNKAPPYSYDEDLSLFIQDYFPRNDSSIEEGLVANPFRWSGEAEAICVNGFSGNSSFSNASEASCTPYVINLVPGRVYRLRFISATALSLVTIGIENHSNLTIIEADGSYTKPWSTDHIELGSGQRFSILLRAKTRSELAAAGNRTDFWVRYENRERPNNVSGYALLHYDIRNRSTNLPPSLPTVPPITLSRNVTGWAEYSLEALNPAEPFPKLSEVTRTIYITMQQVIRVGAFVNGTINGTLQWAQNNLVWQTVQRESNNSAPYLVQLYTTGQTPNYTAALQNGGWDPYSNAFPALPGEVLDIVWLSNSGPTGGWDFHPMHAHGKHYFDLGSGSGVLISHRNGTYNATANEVHFGNYTPAPRDTTILYRYATSGQKDYTSGWRAWRIRVTEDDVGAWMMHCHIVSACSRPAVVYVGGRSRLMADDDAAPTHDHGHADGLGLREQQLDFEQVPYATGELPPFTDGGYAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQM0</accession>
    <name>A0A1C1CQM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Catalase</fullName>
            <ecNumber evidence="13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">cta1</name>
        <name evidence="16" type="ORF">CLCR_07035</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="13"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQM0"/>
    <dbReference type="STRING" id="86049.A0A1C1CQM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07035"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05218"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF26">
        <property type="entry name" value="CATALASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="10"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT50814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="496" mass="56021" checksum="445EA9DCFD1EC95F" modified="2016-11-02" version="1">MAATAGPVYTTSNGRPVTFATASQTVGPHGPVLLQDFHLIDLLAHFDRERIPERVVHAKGAGAFGEFVVTHDITDLTSADLFSHIGKKTNVAVRISTVGGEKGSADSARDPRGFSIKFYTEEGNWDLVGNHTPIFFIRDGVKFPTFIHTQKRNPRNNLKDATMFWDFLSSNQESVHQVIQLFSDRGTPRTFRHCDTFSGHTFKFTKTDGTFKYVKFHVKSDQGHADMTNEEAVALTASNPDYATEDLFNAIERGEFPSWTLYVQMLDPKDAETFRWNVLDITKVWPHAEIPLRPVGKMTLNRNPENYFAEVEQLAFSPGHLVPGIEPSADPMLQARLFSYSDTHRHRLGVNYQQIPVNRPLHAYAPFQRDGAMSVAYQNYGAHPNYPSPLKPNTYLPVDRPIDAAHETWIGQAVHNLQPVTDEDFVQPNMLWEVLGRTEGQQEHLVHNISVHLFAAVKEVRERTYGMFDRVNKDLGARVRSETEKVRAEKGLSPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQY9</accession>
    <name>A0A1C1CQY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08714"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09559"/>
    <dbReference type="eggNOG" id="ENOG502SQ4J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3009728at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650998" evidence="2">
        <location>
            <begin position="22"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="387" mass="42840" checksum="215227C42799144B" modified="2016-11-02" version="1">MASPKRLSLLVLLSLISESKAAVHFKSWYGQFREVLQEIVQRDCQQEYQVYLTQEAPKDYLSMTITPVIDCILGHLNETRKSNIAAAAVLLGLLPTTLGGVGSTTVEVGLVALRRPFLAFLLAAGAPAVSPMRTFDYVDTKDLLAKKPGTAKILPMGPTANTLISSFEYIMAAGAVVNLAFVSYELCIQTVCSFAPEDAFLPALWAFLAIAVHFFGTWSVYLRTRIVLLEPNVTRSWTQHIWRRICAEFTPSAAREVARLEIKDETYLYIFLSWFTSMGTVLHIVYGTLVFSSILFISTSDAVTVVARYLTSTLVCRVIVMYELSGLRQVLSQARSGSHGGSEFIPLQPHAGTSLFDTGRSHSWQSKTSARTEELHLLRSAERRGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR82</accession>
    <name>A0A1C1CR82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_08649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR82"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08649"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09655"/>
    <dbReference type="eggNOG" id="ENOG502SVZ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3469225at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="412" mass="46185" checksum="B924972F036EBFAD" modified="2016-11-02" version="1">MGAGFDVMLPMTFSVEVKRTRDRIARQGLVLSSKISNPASFLGFLATTAAHRAVMYGRHKDLAPSNDNHDDLILDPDYARAKHEATVAVRQIFQQRAIVDEQMLEACFGLISTATVVGNFEEARLHLKILDRITSQIELSEQTLMWLPIANVKISVGLLERPVMPLPFKREPVPDATLRRISPGLPSQMARLGTSFVRLNQLSNSLRRLLSSQTLICHLCAAKAADPQSPSALETSILVKKSTEAEFDLLAYPYEADAFPRNARHEPELPALEGIVRLAALGMLSVAPHTIMPAAGNGRALTHHQKRAVEKWVLEQHLWHAEALHVMCWALLVFIQNSLKQTEEAFFKKLLAQVTHYLGLSDWKDVENVVYGYLYIPGLQSSTWKAVWSDVCRLRAQLYPRDEDRDVGEIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRL9</accession>
    <name>A0A1C1CRL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRL9"/>
    <dbReference type="STRING" id="86049.A0A1C1CRL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09115"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06936"/>
    <dbReference type="OrthoDB" id="4159080at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="195" mass="21305" checksum="C212E5D0DC0860D6" modified="2016-11-02" version="1">MGCDFWSLFTPPSPFRKSTRSHHQSITSIAEANGSAPQADSSLLSHAFRTAADEIEKLPNLPAIAGGDRILAEIQQMRNETREQLARLDERITASHQSLLTALRISDVNNAARVNNTYLSGPSDRLSPFLHPLTGAVIPTFPTTPAEIGRMPEHDLDAILQQLGLQDALAAPTLAMRKTQLRVHIGLRSQLEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRM8</accession>
    <name>A0A1C1CRM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_08535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08535"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06928"/>
    <dbReference type="eggNOG" id="ENOG502TCM4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="431" mass="48426" checksum="310E18C0D371DB8D" modified="2016-11-02" version="1">MDADNARPGESRPQCDETSPQCQRCVKRQIACSFLDTSSDGFPTPPGNAPSYDTSTPRSVDYQPSDPEKPRHGTLPTPKPSSPLATVQDGPNTEKRFDLLDLELIQHYSTRTYMTMSSRLASHAVWRDTIFAEALRHDYLLHALMATAALHKATLQPRSSDAYAEYSRIALAHQNVALAGFIPEVSKPNRDNGIAIFSVSLLLTIWAFASKRLPEGLNNVKLDFGRGESSPGVSLPLHSPTGDFIEVIMILRGIYAVIRETNTWLQGDIEELLRYPRSEDLPPHPPDVLDAFSILRSAVDDPPLTSLWEGEEPHATKSLLLEQMEELRDISRCRSVVEWDGHIFSWLIMAPPAFIHCLKRSNPLALAIFAHWAAMFRCMDHHWWVNGWGYSLVNDVSSMLDPVWARYLDWPRRQVGLVFQGSGGFDGRRMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRR4</accession>
    <name>A0A1C1CRR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRR4"/>
    <dbReference type="STRING" id="86049.A0A1C1CRR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08184"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06868"/>
    <dbReference type="eggNOG" id="ENOG502S0C8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="617" mass="68108" checksum="A100BF2906347435" modified="2016-11-02" version="1">MVYHGPSAGCKACRTRRVKCDQGKPSCNNCIRRRTVCPGYGDVFDGAHRSQNKVVIRKVKKQNVAEEADPASSTPGSDLTVEISPGSTSTASNDSATTKPQGPLQWIIYSATPEERGGSHGKALQLGKSRPARSAESEQTVPPLSIPESLKQSPEDASVNFFFRFYTGTIYDPHLHHSFALVWQPLYLRSSANSPLRLATAAVTVNITMMWSFQGCDARPARKLFTEAIAATREAINNPTEKNMDELLMTILIFDLYDSLVLHYVRNAPTTYGKHKDGALALVKHRGLSNYASIVGRALTNATRHNFLDYSLSHRIPMPAGSEEIFSHPAIGESRAAQLDVLTIETVNTQARLWALRRDASSTMTRAQRRKAYEDIIADAIRIDELFMTWKRAVTSPDWLPLFVSREEVPPSILTAGFYGTKCAVWKDLAAAEVYNLHASRRIFVLQMIRQSLADEPTLLAEANYRAYLAKANAAVQSLVDCICETVPFHLGDTVVPTNPMYSSGVAMPSKTVTDPSTGETRRIPDLEGSDFKMRAAASGGWMIFSHLVDIYRLAEPEDDAEPIVLRDGQLEWVKGQVKRLQTTFLYCDPLWFQRNPSPHMSAAAAAAPAATTGRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRZ7</accession>
    <name>A0A1C1CRZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative lactate 2-monooxygenase PB1A11.03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_08513</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRZ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CRZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08513"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06813"/>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03332">
        <property type="entry name" value="LMO_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037350">
        <property type="entry name" value="LMO_FMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF86">
        <property type="entry name" value="DEPENDENT DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="7">
        <location>
            <begin position="34"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="367"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="390"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="444" mass="49251" checksum="A4AA17F4B385DEBE" modified="2016-11-02" version="1">MANKEETAKLNQPYTEPDPNNYSAYQREIYSSLRAPIFSTKPSEWEALARATVPASNFGYVYGSASSGSTHAANIAAFDRYRIRPHMLVNATRRDMSIELFGKKYNSPLLLAPVGVQKIMHEDAEEATARACEKVGIPMILSSAATRTIEQVAEANGSGARWYQLYWPRPQWEDVTVSLLNRAKANGYAVLVVTLDTFNLAWRPTDLDTSYLPFIWGDGCQIGHSDPVFNARYEEIQRNDTRSYGEKLAELWATLRRPGSVYGAAKVLTNVSLLQKSRAWLDVLNSGTYREWKHLEILKKLWDGPIVLKGIQTVEDAHRAIDYGMDGIIVSNHGGRQCDGAIASLDALAEIAADEKVKRSNLTLIFDSGIRTGSDALKALALGAKAVCIGRPFMYGLAIRGQQGVEHVLRCLLADTDNMLGNMGKKSVKDLSRHDLQIRPESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS31</accession>
    <name>A0A1C1CS31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative metabolite transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_08326</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS31"/>
    <dbReference type="STRING" id="86049.A0A1C1CS31"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08326"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06770"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="46"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT51314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="500" mass="54736" checksum="B4031E19314AE088" modified="2016-11-02" version="1">MDYDKSVQESKLPASSDHDADHERDSAVYTGPLAEVRKGRWERSWPVIACGAGLFSDGYLNGVIGSVSTMLQIIYGEQYTASSYRSAVPSIAFAGTVVGHLFFGVLSDHWSRRNTLLISTIILILFSILCAGAYGAGGSTQGLFAALSAYRFLIGLGIGGEYPAGSVGAAESTGELKKGHRNRWFILATDFQIDLGFVVSAFVPMIVVLATGENHLRAAWRICLALGAIPPLSLIYLRFKLQEPEQYNRNKMHKFPVWLIVKFYWWRCTVISIIWFVYNFSAYSFGIFASSWLVFILPNDAPLWKSFGMATAINSFWLPGALIGAFLADWIGPKWCLIAGVSLQGIVGFAMTGAYGELNQPSRVAGFIILTGIFMALGEVGPGDNIGLFASKLSSTPIRGQFYGVAAAWGKVGAFVGTYVFPLLIDAAGDDPIKQGQYPFWVSSSLCLFSAVVAYFGLPKVGQDMIEEEDERFKRYLEQHGYDTSMLGTKKFREEAGPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS49</accession>
    <name>A0A1C1CS49_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS49"/>
    <dbReference type="STRING" id="86049.A0A1C1CS49"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08785"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06764"/>
    <dbReference type="eggNOG" id="ENOG502RUKM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="37082" checksum="95B50D5CEB22E20F" modified="2016-11-02" version="1">MATTTLAAIQTERQFLPVKADSLPPVPTFEVDANPEDVINALKISGGCKVKSAVDKGVLAQVERELRPHIEADVVWEGDFFPIQTRRVEGMIGKSPICAEHIINHPLYQAVCKEFLTTKNWYWSGSKKVFATSDPQLNNSICFSIGPGAWDQPLHRDSWCHQTNEQEVDVYPDNYDRDVGIGWFVAGKPATKENGATRFIPGSHLWSKDRPPQDELAVHAELEPGDAFMMLSSCYHGGSANKTSDQERLLFSCFMTKGWLRQEENQYLAIPREIVLKMPVHIQQLMGYKLSQPFCGWVESDDPRVVLDPSLKDDPSGHYDEEEKHEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS52</accession>
    <name>A0A1C1CS52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_08991</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SPC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS52"/>
    <dbReference type="STRING" id="86049.A0A1C1CS52"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08991"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06747"/>
    <dbReference type="eggNOG" id="KOG4657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4056921at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="11">
        <location>
            <begin position="206"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT51337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="267" mass="30603" checksum="8783A780CE12BE16" modified="2016-11-02" version="1">MSYSDTPLTQLPSVDFNFDDLRKRMADFTIKFDAFIEQGRKRVLEERNEFRARLGELSGELATSGYKQNHECRLTQLAEERRSTSTQITTLQSTLSTHNQVLVREQAEKNEMHSQINNLESHATQQSAKRDRLRSAIAQTQRQIDAKVHAQREYAAKQDGQSQLNRPELNFWETYLGCRIEGSGDENKVRIVFVFPPSKGSGSGHEDREAFFELLVPLTGHGKYEVTYMKPKLEPARVERVVDRLNATREIGTVLKGMRALFVEAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSC0</accession>
    <name>A0A1C1CSC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_08323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08323"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06689"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="21"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="541" mass="58918" checksum="B5F47984ACC66E3B" modified="2016-11-02" version="1">MRLTRSKNRSPSTDDSFPTGQFLIIAICRLAEPIAVTAIFPYAWIMTKQFGMPDPSFWAGILIASFSFSEALCSLLWGGLSDRIGRRPVLLLGCFGTMISLLIVGFSTSFTMALVGRVFGGVLNGNIGVIQTVVGELTTKPEWEPKAYAVVPFIWAIGTIIGPAIGGILVNPAVSYPDHFSKDGLFGRFPYLLPNLVCAFFMLISMVSAYVWLRETHPDLQNNGTQARRGSFYQSVTEQTPVISAGGATADNAVDLNSDSYGTFNGVDVQKNEQWRLNEDGTSREPSISDKGAGKWLTRKIVMLTLALSIYTYHSMCYDHLLPIFYQDKAAKDVTILAASPFDIRGGLGLSTKAVGVIMSVNGVIALFIQAVIFPFVAERLGTWRVFVLVTVLHPVAFFIVPYLAFLPSSLLYPGIYTCLTVRNFLSILDYPVLLILLKQASPSPAYLGRINGLAASAGAACRCVAPPIAGILYEWGSNIGFTGLAWWAAGFVAIIGVFQLYFVPRPANETTVYKSMVPCLEDPAENRISDVVDITVVDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSF2</accession>
    <name>A0A1C1CSF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSF2"/>
    <dbReference type="STRING" id="86049.A0A1C1CSF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09214"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06665"/>
    <dbReference type="eggNOG" id="ENOG502STPC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2565331at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="95" mass="9136" checksum="51B1CB5CC7651168" modified="2016-11-02" version="1">MPINTSSSDEGVTGAAKFVTSTVGNTLGGVARTVGGVTGALGRGLGDTITGATGSAGKPVGDGLSNALTGVENGTKKVARGVEDAGEWKGGAKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSL1</accession>
    <name>A0A1C1CSL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myosin class II heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07882</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSL1"/>
    <dbReference type="STRING" id="86049.A0A1C1CSL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07882"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06592"/>
    <dbReference type="eggNOG" id="ENOG502QRRG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1293114at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF0">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="417"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="842"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1167"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1228"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1355"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2086"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1501"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1765"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1859"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1942"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="844"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1026"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1228"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1365"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2086"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2111"/>
            <end position="2124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2155"/>
            <end position="2165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2199"/>
            <end position="2216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2223" mass="245253" checksum="36090518CE13B321" modified="2016-11-02" version="1">MNLDGLSQFENSPSAGHHTDFHPLRGYHDAFHSLKEHSLSSTPSENDWVSPFTLPPLPTLRRDRDQPDNFRSPEYLRQRDGSGAYYAAAWGSPYATPSPRRTPQPPSDPASHRLDFEDTPLPSSYTRSFLDPGDDIGGNRPRSRRRIHPHTAAVDPAKELRNLRSERPNWLSDSEDSGSETGQKEGENTPTRVAYLDSWGASPADSVSRVPVKHRSTESLATVTPDTFHASGNLLVGSKRLRTPLPPFGQSNMAEQESENFDTPEMQLPALPRRVSPAEDNMKPPESPTLAARPRPTSMHSYQRPKKKVVWKGKACIIALPLTDRETAGLPPLLTREEIQARIQEWIDAGYSVDGFKLTHLAHEGSEGSTGQSRPVYPDPVEVNAEQKLRQFHVHIPDQAEWESWVESLKEEKLRALGVSPSGSEAPPSTRSPFSATMSRVSSTAYPGLTASPPIAPSSSASNPLRATSNPFSPSLMSSAGISPQPASVASSQFNGPPKNMHGYKPSMAHPGFQGRISPYEPILPQPNAFGNGARPNIQPLSSRQNSFSPNHPLHLPNMGEVLSQPMHVRAPTMQFGGDQARSQLLQSRGHVHPQHAAQHTPSPVLPQRVDSLSHTPQFSESSRTPIEIAHPTPKSHRHNLSMALQREIDEAEAALHAKHDSLHAEDTENLDLSLRKDSVIDDTVNEELPILRRPETMTAADERSDIETNPSIAATPMLMDDKNPFVNWQALSDAAKAESKPVPEPTPTTTTKFNVEAKEFDPRAGFLSSNFSFGAPAFMPIRRAPSKPIPPVERGSAKNRFSISRLNADAPAFTPSFVPQAAPKETPFSFSSATFNVDAPVFNPSQSQGTRSNDNVASDADGVSNNTSSIFGNVVIGSGSKATRRATKPGALLATKSRGVQSDVSEPESTDDGRPMAPADRQKRARRHDSDGDRSPVFADSAPFHHRRILSEIVDDVDANGAESESPKKHFDGWAYIPANETRPDENEPVAAQEKAEDTNQAGEAESAFTFANASDAAMFNEARPPLDSDQKMEAEAESEPETREKVEREIETPEKPSDVSRGYSRKPKSSLSALAKPFEFNPGVSGSLASSSTAPPAKARGLEASKYATVPSPPTKHTTSLSSPPADLPHLVEKDHESLNDAEDTVEVFEDDDQSSVEEVVEVIEEKSTDGEADVPPEFSNPKKELGVQPQVEEDEFEMPGPSLRHQDQPVPSFEEIDAVMKHLEDHPELGVERNDTPIQSTPLVDMRLGGNFRSDAPSPSPRRIHDNKSAQSDTSYPPSYGLGIGIHKLNSGRDDVSDWGDALPAPEAAKLQLRSQFFDGHVNDLVDGILENRLGPLERALETIQHSLTLIATQPTRKKDRRSMSTEQKESDADDEDDYDAFEGFSSYRSRSPIARRGERKHDLIRAAVAEAMAAYQPPLPPQPTIDMTEVNGVLQEMRELAQQTGSQNTQNELKTIMEDVISHHPRLRGSRVREDHEAAELKLKPQIDGLESMLKISQEHAAEEARLRRKAEEEINELKLRLRVAEEEASQYRESSEEAQHTLAAFVEEKGSYKNLERDLEGLTLKNTALEHTLEEYRVSSDQWREDIRNERANNKDLKRTLRELHQQLQEQTQSREGLRAKIERLQSQMAQVIHDMHAEQEDWRNKEHGFQSRIAIAQEALEQERRHREKAELELDALDKEHKANLQLKNVLAQAQLDVSRLDELVASLREENRALDTKAFNLDRELTHTKNSKDAELATSVLKVQTELESALAQSQSVRADSDAQITRLQGRLDDAELRLEEQKAKHDSVLAETREAHQRALREADEKKESALGEQHRSHEKMLDELRDRHAREMHDSFDTRTRLEQQFNERLSLGDDKVKHLENKVADLEDRLAITKSAARAAVEAATAKGVNLPTPASSVVASPPQRAATASMSYAKGSEVPEKISPQALRESIMVLQDQLQNREQQIEQLEAELAAADKDAPAKLKERDTEISWLRELLSVRVDDLDEIATALSKADFDRDTVRDAAIRLRANLQMEQQLRERAPGGSLTSSFPSISSLSSYAQSPRALPLAAAAAWGNWRKARDTSIGALSDLATNLGNQTPSKSTVGSPTAFLSGMITPPATSQKTPTSSDTPLQAPPTMRPLAAAAAQARKGGGPEARPLRAYNSQPRALSSRQAEKRPEISPSQTKPEPPQTPTQVKNQPSFDLTADVDEDASPLDEDADPLETAEPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTB7</accession>
    <name>A0A1C1CTB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTB7"/>
    <dbReference type="STRING" id="86049.A0A1C1CTB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08367"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06347"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="503" mass="56110" checksum="E8FB8B848A535890" modified="2016-11-02" version="1">MAITDTLGLSLPIVVGSLVGLYAVYWTVTTYIQYRKLQHIKGPWLAAISPLWMFYYTCRGTLYLAVEDALKKYGSPVRIGPDYIASDDPVIQRTMNAPRSTFTRGRWFRGMKFDPRQDNILSMADEKAHAELRAKVMPGYSGKEVPNLEKDVDARVVELLDLIRRDYVQNNQALDFAKLAGYFTLDILTQIAFGQALGFLVKNEDLYDYHKSSSAFYPIMELGSNHPTVLAILNSRVMEGAAPKPTDKIGFGAIVGVAQKAVAERFGPQPKKVQDMLGSFVNHGLTQQECEVESLLQILAGADSTATALRTTFLHILTSPPTYSKLREEIEAAIEAGNVDYPVIKHSQAQALPYLQACIKEGLRMFMPLHGLAGRVSPYPNGATINGVFIPPGTEVGVASYAMGHRTDFYGPDADTFHPERWTENDEETIKSFEKYNELVFGTGRSSCLGKGIALMELGKAIFQLLRHYDFTVVNPFKAMKVRSNSVVVQEDFLVRAWPRKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTQ3</accession>
    <name>A0A1C1CTQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">tim54</name>
        <name evidence="13" type="ORF">CLCR_08475</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTQ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CTQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08475"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06267"/>
    <dbReference type="eggNOG" id="ENOG502QPMQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5598305at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF101">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="220"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="350"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT51850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="483" mass="54515" checksum="CC9D50CA35E10C53" modified="2016-11-02" version="1">MADSQTPPKPESLPEGVKYEAPKPPPKQNPVFRMMGMPNFRLRLPSRNWMIFLTIVGSWTAAVVYDKREKKKAQKKWCDLVAHVAQEPLPVNQMPRKLTVFISAPPGDGIRPSRQYFKEYVKPVLVAAAMDYDVIEGRKEGDVRYGTAEQIRRLRRKRGEKGADAIEPEMDAEAAIDMVREKMHILPESGVRGDLVLGRHTWKEYIRGLHEGWLGPITEPAPPLSEVEASPIHPPTKARTDDPSPTTETSDIAQPESEKTPEEETKAEEKKKPYPPPSYLPIDKYSSATLSVNTPSIFEPSQPIHQQHLLGFLKTPQRIYNFLTRRHLADRIGRETAAIVLAASRPYEQGSSFSSFSDTPSDIDPVATRAPESDASPTSSFPPPSGNSHGQVSWEQQFLLMDEESKWHKSVRKPRKEDDTSEPIWTADIVIDERIGFRMRKFDLQPEEEARANRLASGVEKPNVPDPIDLRKEKVLIGNLDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTS1</accession>
    <name>A0A1C1CTS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08941"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="254" mass="27733" checksum="C373F1BFC4A89E1B" modified="2016-11-02" version="1">MTVTKLRRKPAIRSDPNFQDTLSSRSRGMILASEGPATMVLGPSSVGSRCRESSSRSFGAVDTLGWEEGRAWMTVSVHVWSIGAPHLNVLLALGGRRGLSCAADQCRSPPGQIVKPSRIPDDGHGSGQEDQHGKIPQRIVKHARSGAQKHQPPRHLVGDGLLRQLHGRQGNHADRRRVEAREQGIRRGRERVSHVGDAEREGVHSDRTGESSTAWHGMPRSTIMIPSRRRSTVQYSTAQHSIAGAGDPRTEKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTZ5</accession>
    <name>A0A1C1CTZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="13">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">rgxC</name>
        <name evidence="17" type="ORF">CLCR_08511</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="13"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTZ5"/>
    <dbReference type="STRING" id="86049.A0A1C1CTZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08511"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06175"/>
    <dbReference type="eggNOG" id="ENOG502QVQ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651045" description="galacturonan 1,4-alpha-galacturonidase" evidence="16">
        <location>
            <begin position="20"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT51954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="433" mass="47163" checksum="1455595912C0704E" modified="2016-11-02" version="1">MRSSLFRIVACFLPTAARALGPRSPDASGQRVCTVTAKGQQHDDVPQTVQAFEDCGNGGTIVFPEDQTYWIATKLNPVVHNVTIEWRGIWQFSDDLDYWRNNSYPIAFQNHQAGFILTGDGIHIDGFGTGGIHGNGDIWYTAEAGHTLPGRPMPFVLWNVSDVTVSRFSIEQPQLWAFNIMNGTNIRVDQLYCNATATKAPWGSNWVQNTDGFDTMDVKNVYLSNLVYQGGDDCIAIKPRSYDVSVYNMTCRGGNGIAIGSLGQYLEDSSVENVVVDNVTIIRYNEDMKNGAYIKTWIGEQAPQSNYESAGLPNGGGWGHVRNILFSNFNIQGADLATAISQSNGNPKDGTFSGTSNMLVSNVAFVNFTGSSNITAAKSARVNSISCSQRHPCYNIDYQNFMVAPMANASALGLTTCEYIEEGGVHGEDCTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU36</accession>
    <name>A0A1C1CU36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1604 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU36"/>
    <dbReference type="STRING" id="86049.A0A1C1CU36"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08110"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06121"/>
    <dbReference type="eggNOG" id="KOG2138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20507at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="151"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="720" mass="78752" checksum="8BC8652C7C6E7A1D" modified="2016-11-02" version="1">MSYKRSRQAFEADLQKQASPFVLYGTPLPPLDDHTRDDGSFVPVWKQEVTDERGRKRLHGAFTGGFSAGYYNTVGSKEGWAPSTFVSSRQNRAKDARRAPQQRPEDFMDEEDMREADESRTLDTSKEFAGFGTEHDSVRKSAAIDMFRPSGETIGLRLLKRMGWREGTGIGPRVRRAAKLGDDEDREETGETHLFAPEDAQVVSFTRKTDYKGLGYEGELQEKEQSANGKSRSHKTAPKERSSDEDSVGPLLSARKKPASATKRTGFGVGVLNDDGSEDEDPYSMGPRISYNRSIGGDRKVRTKPKPAASSANPLVTTKPTFISKRLANLKGALRKCHDGRLPPDGFVLADELDSFGAMTLQDDKYKPPEVPAAWKSSLSPDVETDTNSTFVSTSEAAKASHLTAKARASLLGESQLPGKSVFDFLTPAARDRLAAASGRQNLPAAGNESAPAGHESSKSATAKLQDLVPKLEQEVARQALERGVGGWMPYAEDENKRSRYRTYLEIQAGLRPAEDITPRAEHMRQEDWVLEMQEFARAAEVFKPISGLMASRFTTSTSLPQGQNATSGEAHVGSLLSKSKAKPEDPAEAAAKLGMFGPMTRCTSNFYPTRLLCKRFGVSMPTQAAPGDAGTGDSRVYAPPEPDFATTQFRSFASAGYQHDATSEVNRTTAEAPVGQQQSLPTGKEELEVMDPERNEALEQQRPGQAIFKAIFGSDDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUI1</accession>
    <name>A0A1C1CUI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_11382</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUI1"/>
    <dbReference type="STRING" id="86049.A0A1C1CUI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11382"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT52148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="111" mass="12294" checksum="C304B2D566778AC6" modified="2016-11-02" version="1">MIGSDKVSTRLRTDRYERQLSGQFQKSDNMVLAIDLLNPTPQAEARKHKLKTLVPAPRSFFMDVKCPGCFTITTVFSHAQTVVICAGCSTVLCQPTGGKARLTEGCSFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUL1</accession>
    <name>A0A1C1CUL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUL1"/>
    <dbReference type="STRING" id="86049.A0A1C1CUL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08671"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05966"/>
    <dbReference type="eggNOG" id="ENOG502SQGV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21456">
        <property type="entry name" value="DLC-like_SpDlc1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="377" mass="41339" checksum="C5E91002935CEF93" modified="2016-11-02" version="1">MSTVRTLRSITNLFDSGKHSRHQQQNAHATTPDSGSHSPAAVEHRRLRKASHLHRSNSALLDASVSAQGTFTLQHHQSEHPLTEFRRRLARKASTFSLRTRRRQGERDQGEAAKEEEKLRELVLSGSDKGAVQSVQERSPNNCQADKSHQEGEKAVETQAGEAQERAATRNSSLTTVRVWDPTESPSVKQLPPLPTTADWADKTLPLQGVIHQTQETYTTEEVAGGRTSVKKMASEQPQPPVPYTRLKEITEHACETALSGVTSYIHTDTEKWNTTIINSILGALVQETTQSPPAGSSAPAQPQFKYVVNSTIIQHAASSSSSPGDDPKKTSGRRGMHAASGAYWNNEKDGMWSFKYPGADSKGLDVVVGIIWVWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVC2</accession>
    <name>A0A1C1CVC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OBAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVC2"/>
    <dbReference type="STRING" id="86049.A0A1C1CVC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10839"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03849"/>
    <dbReference type="OrthoDB" id="1901244at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360:SF0">
        <property type="entry name" value="OIL BODY-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="183" mass="21146" checksum="67E455C99948EE0E" modified="2016-11-02" version="1">MSQNQVVAPGLSGLAAWTLKFSPTAWFKSWLLYLGIQTHVGSTMQPEMKPLHNICEYLHALHIYTDEARRGEVRTRIISALTLRKVSRAGATCEEHHFDQVLDLRQCLIYDSCKPGARLIGVEYMIPKHRYLKLDPEEQKFWHSHEFEVKSGMLVLPYPASHARQKDKWDELETKAMEEVVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVN6</accession>
    <name>A0A1C1CVN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbamoylphosphate synthase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVN6"/>
    <dbReference type="STRING" id="86049.A0A1C1CVN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10026"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03986"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="546" mass="60766" checksum="731893D3C13F9A36" modified="2016-11-02" version="1">MLDGSSSLLAHRLQNAALLFLSVAFLPLDTFILFASFLSRAILPNEVEHHRREARHEHGFHPRTILVTGVGMTKGLALARLFYEAGHDVVGADFEPDGALACGRVSRSLKKFYRLETSALKQGIPPSGNSPDRYIQNLLDIVTREKVDLWVSCSGVASAVEDGMAKEVVEARTSCKAIQFDVHTTQILHEKHSFIKHTRDIMGLHVPETHEITSRAGVEAILRDTPPGRRYIMKTVGVDDSFRADMTLLPRDSGVETSKHLARLKISPQSPWILQQYIRGNEYCTHSLVVDGQVKAFVACPSAELLMHYDGLPFESPLSQAMLDFTRRYAAHGGKAFTGHLSFDFIVVVVVEERDEKAPLSPEDITLYPIECNPRAHTAVALFNGTTALVDAYLSALDLDSIDRSSNGTSNNDTNGAATLVIHPARNDKYFWLGHDLVTRIILPTLSLLSALFLTTTSGHSAASSAPSTSTSASASATISTTLQSYAEFIRHVASPTWKDGTFQYWDPLPWWWLYHVYWPLRFWDSLVRARKWSRINVSTTKMFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW21</accession>
    <name>A0A1C1CW21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW21"/>
    <dbReference type="STRING" id="86049.A0A1C1CW21"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10369"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04087"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF3">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="13"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="384" mass="41968" checksum="A31D609897B465AC" modified="2016-11-02" version="1">MATHPAVVTVGPGLPLEILQVPTPTPTGNEIRVRALWTASTPLDLHQADGGLLVQHPQLLGDGVAGRVVEVGPHATKYQPGDIVFGFTWRNQAEKAHQEYVVAPEFLFGKLPHNVTMQQAVTLPNNFVTAWHTLTKEFGFDLPWPKPDGYLPEAQERDAGILIWGGSSSVGQFALQILKHYGYTRVITTASRAHHEKLHHHYGAAKCFDYRDPDVERDIISFAEPHERATTADPVAKNGLAYILDCIGSLQGSVLPVSRIARLTATSRGTKVAVLLPIIITDPSPGGKPVYEMDVLAAAADWPVGVEAVGVRTHSYLDDAALKDKLQSEIMPSVLERGIVEPNEQLIVEGATMLERAEKALTLLRDKKVSGERLVWRVADSHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWM1</accession>
    <name>A0A1C1CWM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adaptor complexes medium subunit family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_09980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWM1"/>
    <dbReference type="STRING" id="86049.A0A1C1CWM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09980"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04281"/>
    <dbReference type="eggNOG" id="KOG2740">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="870at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="7">
        <location>
            <begin position="193"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="553" mass="58395" checksum="7E6345E614C1BFDB" modified="2016-11-02" version="1">MSVTLDALYIFDDHNKCVLEHIYSGRPPSAQTLIARLATRPVPRPSVTQLSDLAPPTTAYCISHSALQLIAVSSKDAQSLAILDFLGRVLDIFEDFLGSPLLTSKIEDSYEIVAQLLAEMCDGGIICNTEPNALRESVEVSSVLGKLFTQVGLPGASPALGPSSNFASSLRPSPTTSQGPAIPWRKSNVRHTSNELYVDIIENLSVVFAPSGRPISARSHGSIAFTAKISGIPDLLLVLTAPGGSSSAKTAGITRTMQLPVFHPCVRLARWKEHPGELSFVPPDGRFMLAGYETDLMPTSLDTDQPPSKTDKIFLPATVDLRGGLGAAACDFEAKLTLNNNFPGVVSSTKSNASRTSSGPISSLSFGGSNTGSSSAPTLETVMVTIPFPADVRSATELKASRGEATFNAFDKVVEWKVPTKDGASINGTATLTGTVSGPFNPADGLDEETQAAEAGKLNSMAGYYNEEVVANQGAGPDPSPNGSGKRMQASKALMPRSISVSFNVKGWIPSGIKVDSLVVDVKKSKGLGDGVRPYKGVKYLTVSRQGVERRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWZ2</accession>
    <name>A0A1C1CWZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWZ2"/>
    <dbReference type="STRING" id="86049.A0A1C1CWZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10413"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04240"/>
    <dbReference type="eggNOG" id="ENOG502QTPE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="54"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="370" mass="41527" checksum="A0455D9946A73EEC" modified="2016-11-02" version="1">MVNVVSCLPYLSWSQHPKEHPLPHIQSSRVATPCGNLELLCCQPQHRDPKTPPLIFVHGGFGFAAVWLDWMTHLYERGYAATMYAYSARSHGASYAVPYLQMAWGTSLDDFASDLGTVVKTITTHLEDEKEPILIAHSAGGALVQYALTNGMITATAFCLVGSVPHFGGLDAYWNWTKMDPWMHPRSWILGLHPMSGLAHPKLVRQMFFSDRFPMAKVVDFMHWMAPYESLGWAGGQNGSFWKWLMGKNEWLEPMRILKAVTGWDRRGDRVCVMVGSQDRMMDLNMARRQVSEFRAAVRAMALESPASQGSRGADADAKESIHTEDIPEVEAESLERVRLVVVQGAGHHTQNDVHRQAAAAAIWQWLEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX71</accession>
    <name>A0A1C1CX71_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cell surface mannoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MP65</name>
        <name evidence="6" type="ORF">CLCR_10216</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX71"/>
    <dbReference type="STRING" id="86049.A0A1C1CX71"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10216"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04320"/>
    <dbReference type="eggNOG" id="ENOG502QTKT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="941679at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF14">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651126" evidence="5">
        <location>
            <begin position="19"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT52980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="438" mass="44797" checksum="BA48829C5ED8A7EE" modified="2016-11-02" version="1">MKATLLSVAVVCAPVVLAVPHGDNHRHQHAARRVETEYSTVTDVVTVTANNAVVWVDQFNNVLSTEYHGHPTPTTLPSSSDTMSLAVTPTLAANAAFASDLEASTETPESSAAPTTSIPDSVFSVYFAPAEATNSPVPLTTDDPDTTTAAPTSAEPSVAPASDDRIANKGMHGGHGGASSDNSAAGGGFGIDFELIGSNGCKPQAQLNSEFGFLSTQGFSKIRFYDIGCDLSVATAAAAAAGFSVTLGLNGIGNVNGDLSILIGMIKGNWGPIDTVVIGNEVINQGGNPGQIADAINSGRAQLQAAGYTKNVVAVDTFMAHIAHPQICQASDYCAVNAHAFFDANTAAANAGTFVKNIIGNIQTNGKAIIVTESGWPYEGGANGLAIPSPENQQAAVASLKAAFAGNPGGLFLFQAYDASYKPAGAFGVEPHFGIYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXG5</accession>
    <name>A0A1C1CXG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative acyl-coenzyme A synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_09872</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXG5"/>
    <dbReference type="STRING" id="86049.A0A1C1CXG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09872"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00195"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="28"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="447"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="549" mass="60373" checksum="0717288BB1C18CC1" modified="2016-11-02" version="1">MTSSGGQLESIHDHNLLSLLFSNHERDDDSVVWRDGKNGDQIITKAQTRKLVRQLTHGYRQSGLIEGGKRDPDKVINLTENQVIGFPNVLALIASGAVVATCPWQATAHELLFRVRTLRPKAIVCSKTTLPLAMASRKSSGHWFSIVVQDSETMTVEDEEGRSFISDQETPWDTAWDEEIANRTAVMVFSSGTTGSPKGVCISQRNIISMILQLRHLFRSIRSGKQVLKMAGILDSAHVAGLFIHSFCPLGVGVEDILVPATDIDLLLQTYNRYPIELMFCVPTVLTRLLAHDNFRRTNFKNLKYITTGAAKTTTVVQQEITRALTPGVYCQEAWGMTELTFLATMHAPGVLGPWNSVGKPLRGNVIQIRDDQGKVVPVGQTGEIWVSGPTVTPGYYLAQVNDHDAKKDGWLRTGDLGSVDQAGYVYIEGRNKDLIKYNGAQISPHELEGVAREHGAVLDVGVVGLDLEDGNELPTAFVVLKPGSPPAAITGEILSFVNSRVSPYKRLRGGVYVLQELPKNAMGKLSYKDLRELAKKLHKTSQTARSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXL0</accession>
    <name>A0A1C1CXL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_10448</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXL0"/>
    <dbReference type="STRING" id="86049.A0A1C1CXL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10448"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00285"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT53317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="319" mass="34720" checksum="845781351D340FB9" modified="2016-11-02" version="1">MGASEGSTANAAVRIVDIGVGQSQGTRDHQEDRFKIVRPGEHFGRNIALFAVYDGHGGDSVSNFAEHHLHEILSHELQHQHGRDAFDKAITKSFQEVDRRLRKRGIGETTGSTVSLALVDVGKGTMVTADLGDSYAFLGVQRDERPLEVLKLSQSQKPGEKSERERIEKAGGQVHDDFGGARIGGINLSRALGDLDYKKPGPGEKVADLKDPSHPLSNILKTDLAKATGLADANDHDMLADWISNIPHTNYQSLTRARRYILLLASDGLGEEKDGASSLSWAANQWDKGVEATHIARQLAEKSSRRTSDNSTVLIAVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXV1</accession>
    <name>A0A1C1CXV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Psi-producing oxygenase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ppoA</name>
        <name evidence="8" type="ORF">CLCR_09542</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXV1"/>
    <dbReference type="STRING" id="86049.A0A1C1CXV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09542"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00293"/>
    <dbReference type="eggNOG" id="KOG2408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF37">
        <property type="entry name" value="PSI-PRODUCING OXYGENASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="970" mass="107674" checksum="1EBE4E5852ED8621" modified="2016-11-02" version="1">MPSLSSKLKGMLHSDHHAKTRSQRPGVDAEPDKRKGPEERSLSGSASSSASSTETDKSDYVLDVLKSTFQLKHLRTVKDVALQQIDGEPIDDKTYLMERIVQLAADLPVSSRTSATLTNAFLNQLWTDLQHPPQSYLGADYIYRKADGSNNNILWPGLGAAKQPYARTVRPRLMQAVARPDPALLFDVLLSRKKFKPHPNKISSVLFYVASIIIHDIFRTNHDDFSISDTSSYLDLAPLYGSSTEDQHAVRTMRHGKLKPDCFSDIRILGFPPGVGALLIMFNRFHNHVAENLARIDEGGRFSKILRPPGRPKPADAEELYDEALFQTARLVTSGLYVNIILKDYVRTILNLNRADTLWNLDPRSEEGSAFFGHKIPEATGNSVSAEFNLVYRWHSCVSERDEQWTKDAYTRLVGTDSSLSMDKFLRALNEWAVSLSPDPMKREFAGLQRLPDGSFRDEDLASIWTASVTDVAGSYGANHVPDILKNIEVLGIMQSRSWNLASLNEFRQYFKLEPHKTFEDINPDPVIAEQLRRLYAHPDNVEIYPGVVVEAAKEPKLPGSGLCTNFTTSRAILSDAVALVRGDRFYTVDYSPNNLTNWGFNAANYELNINYGCVFYKLVLTALPNNYAHNSIFAHYPLVVPEENKAILAKLKKASLYDFAMPTGTVQHGTDVHRAVTKVSASPVLGNAPGLHLGLVLVESDGLPEATGAFYSNVITKLLQSECYELAGRQYVDVVRDVFNIAHAKFVTDLFLLPQRSAPELIALLSTIHGHATARQPAQRFVLMNRDVEARHRFVNLVQEEASRAVKDHHGLHLGSTGPLRRHGLQAIQAVAKKGLSPEEIASAQIVPLAALILVSQARIFAEILDHVLTTGEGQSPLDGLKGHQPDPSVLSNTIGSHIDRETLEGKLAVTTVEVTLRAMGDLKKLDRAAGPTGRLRRVGEGEETSYLDVEESTFSMYPVSMMVHWEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY30</accession>
    <name>A0A1C1CY30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_09543</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY30"/>
    <dbReference type="STRING" id="86049.A0A1C1CY30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09543"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00396"/>
    <dbReference type="eggNOG" id="KOG0469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="17"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT53429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="843" mass="93398" checksum="A61FCF830D718222" modified="2016-11-02" version="1">MVNFTVDEIRALMDKPANIRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYAHLPNEEDLKDIPQKVDGNEFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVIINKVDRALLELQVSKEDLYQSFLRTIESVNVIISTYLDKALGDVQVWPEKGTVAFGSGLHGWAFTIRQFAVRYAKKFGVDKAKMMERLWGDSYFNPKTKKWTKVGEHEGQRLERAFNQFILDPIFKIFDAFTKGKVDQLVELCAKLDIKITSEEKELPGKGLLKAAMRKFLPAADALLEMMVIHLPSPVTAQKYRAETLYEGPADDPACIAIRDCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVRSGLKVRIQGPNYVPGKKEDLFVKAIQRTVLMMGRTVEPIDDMPAGNIIGLVGIDQFLLKSGTLTTSETAHNLKVMKFSVSPVVRRSVEVKNANDLPKLVEGLKRLSKSDPCVLTQISESGEHIVAGAGELHLEICLKDLEEDHAGVPLKISDPVVAYRETVGAASSMTALSKSPNKHNRLYVIAEPLGEEVSKEIEEGRINPRDDFKTRARILADDHGWDVTDARKIWAFGPDTTGPNLLVDQTKAVQYLNEIKDSFVSGFQWATREGPIAEEPMRSIRFNIMDVTLHADAIHRGGGQIIPTARRVLYASTLLAEPGLLEPVYLVEIQVPEQAMGGIYGVLTRRRGHVFSEEQRVGTPLFTVKAYLPVLESFGFNADLRAGTGGQAFPQSVFDHWQILPGGSPLDPSTMVGKIVTEMRKRKGLKENVPGYDNYYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYB0</accession>
    <name>A0A1C1CYB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NOP16</name>
        <name evidence="9" type="ORF">CLCR_10737</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYB0"/>
    <dbReference type="STRING" id="86049.A0A1C1CYB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10737"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00385"/>
    <dbReference type="eggNOG" id="KOG4771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT53418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="230" mass="25960" checksum="0C75A3E9BF6EA9F8" modified="2016-11-02" version="1">MGRERQKKKNRSSISKARPKDNRTKAGKKKINFLGNETIAKNWDRKLTMSQNYKRLGLSSKLNAPTGGTEKKANTGTSNAASKRDSLAIAGLTPANPLAQEVQVERDPETGRIVRIIRPEEEEEEDNPLNDPLNDILDYKTPNDSTSKPGNDIVAQLEAQAAKEEELLAKKRPRQQSQREEEWISRLVEKHGDDIKAMVRDRKLNPMQQTEGDIGRRLKKWKASHGEVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYD8</accession>
    <name>A0A1C1CYD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Terminal deoxynucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_09683</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYD8"/>
    <dbReference type="STRING" id="86049.A0A1C1CYD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09683"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00437"/>
    <dbReference type="eggNOG" id="KOG2534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF29">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY PROTEIN POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="580"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT53471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="754" mass="84648" checksum="E323E6776A5CFF97" modified="2016-11-02" version="1">MASSTSSHRIDLSSAPPIFVLQSHLQPDKLHETEDLIYQSGGHITYDAKEARLFIGRVARKTRAAFDLRAQGVWTEDSALPEESRDGGGNSNTPDEGPPKKKARLSSHHGAGPSTRHRRDSSSTVSASPELSPQGAARPSSEVFWPDLSDHILVVKLAWLDACSKDGRLVPYKPYVVYTAKIVPKPDGETTPKTSPTHTTYAKVDSPTASQASSLRRTSRPDPSSILERARAEAATLPARRRRWGDHAHHSPTPSSQHHKAPKLHRTTTSEMEYIAAHPLPPLPDWATGPYAHYSCCRSTFLTTPNSAFISQLTKIKDARQLRLDDIGVRAYSTSIASISAYPHRIEHAEEIVRLPGCEQKIASLWREWQDSAVTDTERYIQEVQELDAEPDLKVLRLFWNIWGVGAETARRFYYDHGWRELDDIVEFGWQQLTRVQQIGLKYWDDFQDKIPRAEVKAISDVILQHARLVLDIPEDKFGTKDDVECVIVGGYRRGKALCGDVDVVVTHRDEFKTKDLVGEVVCSLEDAGYITHTLTLHTTTSDRGQATLPYRAQPHRGHGFDSLDKALCVWQDPLFEEDGAGDDTGAGAQGENESHENAPPPQGKKKNPNIHRRVDIIISPWRTVGCAVLGWSGGTTFQRDIRRFVSKVHGLKFDSSGVRNRGNGRVLDLEGPRLRLRSNHGSGLDDIDKNNQKEIEREKEVIDLLLQGTAIEKDDERWKGMEWDDEDTWWDRERRLMEGLGIGYRPAEERCTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYJ6</accession>
    <name>A0A1C1CYJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11019"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="73" mass="8076" checksum="91ABDB6E5F0C929F" modified="2016-11-02" version="1">MTYTESERATPQKPHNLVSGSCRLEIAHGILAQAPIPATPLPFRVHRNIFEVVKEAVSRELAENVGQEERPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYU1</accession>
    <name>A0A1C1CYU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative magnesium-dependent phosphatase P8B7.31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYU1"/>
    <dbReference type="STRING" id="86049.A0A1C1CYU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10691"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00648"/>
    <dbReference type="eggNOG" id="KOG4549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="268" mass="30289" checksum="AA11B4497CFBF620" modified="2016-11-02" version="1">MPRSTRKQTHQHVVPTESPIIPSTFTDSLPLPSLIVFDLDYTLWPFWVDTHVSSPVKPAVPTTSQSKDNTSGAPQINTKMLDRWGESFTFYPQVPAILASAREKGIVMSLASRTHAPELAAEMLRGLQVPFPGTTTMTTTTGEDYDAKDRPRKALKAWSFFTHPQIYPGTKTTHFRKIQQQLGKPSRSDQNPLQGRTVPFEDMLFFDDEGRNRNVETDLGVTFWLVPDGVDCDEVDRGVWEWRRRRGITPKDLPGRDGEQHNVAELEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYX0</accession>
    <name>A0A1C1CYX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Annexin A11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_10258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYX0"/>
    <dbReference type="STRING" id="86049.A0A1C1CYX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10258"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00579"/>
    <dbReference type="eggNOG" id="KOG0819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009117">
        <property type="entry name" value="ANX14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01813">
        <property type="entry name" value="ANNEXINFUNGI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0041">Annexin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="436" mass="47653" checksum="25AF013FB687ACFB" modified="2016-11-02" version="1">MSYGPPQGPPPGQYGGHAPPPGPPPGQGYGQGYNYGYPQGPPPQQGHGGYQQFGSPAPPPPQQHGGWAPPPGPPPGQYGGPPPPGQGNWGPPPPQGPPPGQYNQYGGSPPFAPPAQPSPGYIPGAAAQGDASRDADALRAAMKGFGTDEAALIRILSKPDPLQMALLRNTYNQRHRRDLEKDIKSETSKYFRDTLVALVQGPLMHDVHSVHEAIKGLGTKESVLNDVLLGRSNADLRAIKAAYQQTFRHTLEADVKGDLSLKTERLFDMVMSATRNEESAPVIPHELEHDCSELHRAMDGRVGTDQIAVCSILAKRSDGQLRAIAHHWQQKYHSSLEKVIESEFSGHMRDALVLMVRRATDRAMSDAIQLEDAMAGVGTKDVLLVQRVVRVHWDRMHLDQVKRAYAHRYKRDLIKRVKGEIHFDKYYEGVLVACLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZS5</accession>
    <name>A0A1C1CZS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10304"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00888"/>
    <dbReference type="OrthoDB" id="4121065at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="416" mass="44995" checksum="5D775C82E517B37E" modified="2016-11-02" version="1">MVTTRLGSRIDASSPQSVNKRRRFSSVEADDHIVVEVPVHEPKAVKEREISGEVVPGHESDEDAAPEVLSSRDAARQARELPNRSLRHASNKRRRAAEEHLPVGKPGLTPSVPGESKPENAPMSGAASLQPDEVLPQNEASMTRILQPLAEEIRPLSTINSENGVSNVDAARIPVEVTENTAVLDDQKSETAQFLPNMAKNGGGDEAPTPAPELAAEGKTALVTNEPGDTLDSVPQMRSLGDVTPRAGDEVLEKTPMNEPQSAIEPDRSLPGDSTTQLRVEALLQNSKDKAVSQPAGHNPTLSMPEADMQTIGTTSTQEDQISGTPRSSTSSVITPVWRTRAYDETPLTAVQSPSLAPAVKATHARSNTLPRPQDLISRRPKTTSLQRYRDRLLNRHQRTTNWGPPGFRKTKFVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0C8</accession>
    <name>A0A1C1D0C8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_00284</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxin-14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0C8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00284"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09443"/>
    <dbReference type="eggNOG" id="ENOG502S3Q3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="9">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="245"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT54198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="419" mass="45631" checksum="239652CA6687821F" modified="2016-11-02" version="1">MSDQDSRKAPAIPAWQQSWQSSTKEQTTPSGDQSSTEQSTTQPSLPSEPPLLEQAQKSLEDESIRDASRESKVEFLQKKGLQPDEIEKLLGPEPAVSSTATDEASELKTIHDTSSSPGIREQEQAVSSPSSPPPASASAPRIEPAPTPSAKRDVPPIITYPEFLLKPQKPPPLVTFDRLANAAYVLAGVSALTWGASKYLIQPMLESLTEARHSLAETAEADLETLNTKLESTVSHVPYIPSVSALHSQQQKPKDDDQESTDSDPTELFHRDIATQTSPHPTHTTSLWSDDDDALPAQDPTTSQSSRLRSLHSTLSSLLSSQTTHFSQDRLKESMSDFQSTLDKLEASYNPFQVDYTSSFSSYSGPGAGDKSNGDKSAKKEASEATKFKNEIRALKGAFLSSRNFPTARPAQPFMLPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0W0</accession>
    <name>A0A1C1D0W0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_01018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0W0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01018"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="75" mass="8076" checksum="29E2D6B61785702F" modified="2016-11-02" version="1">MENRNSTRSVSSSLAKRANLEFTVCSPRMPITEPVVSRPVASILGDPDLTVDNTSGRSMMAGALSVLLSHMLLQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D149</accession>
    <name>A0A1C1D149_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-acetylated-alpha-linked acidic dipeptidase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NAALAD2</name>
        <name evidence="6" type="ORF">CLCR_00787</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D149"/>
    <dbReference type="STRING" id="86049.A0A1C1D149"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00787"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01707"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651201" evidence="2">
        <location>
            <begin position="20"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="171"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="348"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="4">
        <location>
            <begin position="602"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT54446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="713" mass="77602" checksum="DCFD62762E439A30" modified="2016-11-02" version="1">MKVNKALPLLVLQATSVLAHTGEHFHPRVFDPRQALSKRQEAPFPPILEPNEAILLNSFDNATIEGWSYYYTHGLHLAGTNKSQAQWTADRWSEFGFTSGLASYYVYLNYPVSHSLTATFANGSAYTPQLEEEVLAEDEVTSYPNRVPIFNGYSPSGNASAEYVYVGRGQKVDFERLRALGVPLEGKIALSRYGGPFRGLKVKNAQDYGMIGVILFTDTADDGNITEANGYAAYPHGPARNPTYVQRGSVEFVSTYSGDPDTPGYASKLDSPRADRSVVIPQIPSLPISWKTAQPLLQALDGHGVDGKTVNRTNWVGKLNATYSTGPAPGVTISFSNVARDEITWIWNSIGIINGTNQDEVVILGNHRDAWIVGGGSDPNSGSAVLIELAKAFGALLKTGWKPKRTIILASWDAEEYASVGSTEWVEEYIPWLKDSAIAYLNVDQAVAGPDPALSATPELHDVVAESLKKVVYPYHGYSNLTLYDVWYGLSDGEFEVLGAGSDYVAFLHNGIASLDTGAGQGPNDPIYHYHSSYDTFHWMKTFGDPYFTTHKAVGQHLAILVYHLANDDIIPFNVENYGIHLTSYLNDLRDLVESENATSAVDLSPLEDAIATFNASAAAITAFIQTSTTEADFKIINSKLRDFSRGFVSQGGLPTREFYKHVAFAPGLDTGYAPVTWPGVTEAVQDGNLTLASSWVLKSARAVEVAAAILAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D228</accession>
    <name>A0A1C1D228_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rna14</name>
        <name evidence="7" type="ORF">CLCR_02727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Nucleus and/or cytoplasm.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D228"/>
    <dbReference type="STRING" id="86049.A0A1C1D228"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02727"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04910"/>
    <dbReference type="eggNOG" id="KOG1914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="6">
        <location>
            <begin position="229"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="877"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="979"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="986"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1026" mass="113930" checksum="1292678746CDF8AC" modified="2016-11-02" version="1">MATPDREALSPENAPQSSYLNNGSAARSDQASASPSQTFGTSEQSPVNTQKDPILSPIQSDLHHPPAAPVGNFVGQTPMAQSVPAQPKPRIVGGFEVDDDPEDEEGAQDEKDDADVYDPSVGMDFDAPTPADDSANQISTSLDRSSQSPEKENGITPAPVQATGSPADADLSSSTPAPGASTELHAPRAATATPSHTVPDLPAQLSPPHPHVNGLVAPGLPKSRLAHDVVGILEDRIKDDPRGDIDAYLELIDEFKNRNKQEDARRVYEEYLKVFPFAADQWCAYVKFEEEHDRMRPMETLFNRSLLEVLDVPLWSLYINYIRRRNSMQTGDVARSYGIINDSFSFALKTIGMDKESGPLWQDYINFLKTGPGTVGGTGWQDAAKVDTLRAAYQKAIAVPTAATTALWKEYDAFETGLSKINGRKYLQEKSPVYMTARTAYTQLQNLTRDLKRTSKPRLPPAAGFEGHAEYMQQVGLWKQWIEWEKEDNLVLKDEDLSLYRSRILFTYKQALMALQFWPEMWYDAVDFCLTNGLETDGMKLLNHGITANPESPLLAFKLADRIEASTQNDESADPGAKERMKKIREPYDRLLDAIYELIKKVSAREKQDVQRVELAAASNGEGDGNGDDDINASNVAAKKAALDNQIAVIKKGAQAQTDVLSRMVSHAWLALMRSTRRVQGKGPPGEKGPQGFRLIFTEARKRGKLTSDFYVESARIEWQCYRDPAGTKILERGMKLFPEDDYLPLQYIQHLFDIQDVTNARAVFETTVKRLLGHEDPEQTAKAKPLFAFMHNYESKYGELAQVQALEERMRKHFPEDPTLKLFSSRYSTPLFDTMHVHPIISPQQVRPLQSHVLPSVETSTEMVNSPIQKVIDAITTHSPKRPFPDDLEDSGGPRKMARGESPLKGAAGRRMNQQQQQRQVNAPAPLPSFPPVPQPLPPGIAYILSILPKASTYVETRFDAVKMMELIRDIKLPAPSAISSQTLQPPPSQPQPGWPPYPPMPPQGFSPPPNVTQGQYGAAPFRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2N1</accession>
    <name>A0A1C1D2N1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_02759</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2N1"/>
    <dbReference type="STRING" id="86049.A0A1C1D2N1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02759"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05129"/>
    <dbReference type="eggNOG" id="KOG2039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10023235at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00175">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000010">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000001">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000019">
        <property type="entry name" value="Transcription factor (Snd1/p100), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000030">
        <property type="entry name" value="Transcription factor (Snd1/p100), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016685">
        <property type="entry name" value="Silence_cplx_Nase-comp_TudorSN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017179">
        <property type="entry name" value="RISC-Tudor-SN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="162"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="313"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="479"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="9">
        <location>
            <begin position="697"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="606"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT55037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="880" mass="97737" checksum="E3F5219711C7EBE6" modified="2016-11-02" version="1">MALLQARVKSILSGDTLIITNQKGAERTLSLAYISAPRLKREGDEPFAFQSREFIRELVLGKVIQFQILYAIPTTKREYGRVILPDGKELPNLIVQEGWAKVREDAGKKEDDEEALAYLDKLRSLESEAKSQGKGLWAKGGQIENSSEVSDPNAFVEQHKGQKIEAVIERVLTGDRLIARLLLTPTKHIQTMLVLAGVRTPATKRTTPEGKDVPAEPYGTEAHAFVDERLHQRKVNVELLGVTPQNQLIANVLHPKGNIAMFLLEAGLARSNDQHVTLLGNQMAQFRNAENAAKNARKGVFTGATASKAAGVQEADFTVVRIQNGETVFIRTRSGEERKVTLSSIRQPKPSDPKQAPFQAEAKEFLRKRLIGKHVKVSIDGKKPASEGFEEREVATVSVGGKNVALALVEAGYASVIRHRRDDDDRSPDYDALLLAEESAQKDTKGMWSEKPPAAKQYQDYSESLQKAKMEASVLQRQKKVPAIVDFVRSGSRFVVLVPRENAKLTFVLSGIRTPKPARQSGEAAEPFGQEAYDFANRRCMQRDVEIDVEDTDKVGGFIGTLYVGRENFARALLEEGLAEVHPHSAEKSGHSNELFAAEKKAKEARKGMWHDWDPSKDAEDDDSTPPTNGNAGTNGDAAEPASRKKDYRDVVVTHVDETGKLKIQQVGAGTTALTELMNAFKSFHLNKANDQPLAGPPKVGDIVAAKFTADDQWYRARVRRVDRDGKKADLTYIDYGNSETVPWTRLRSLTQPQFSTQKLKPQATDAVLSYLQLPTSEQYLRDTVDFLMEQTDGRELVASVDFVAPEGTLHLTLLDPKVSSKIEESINAEVLREGLAMVPTKLKPWERQAGDTLAKFKELQEEAKKERRGMWEYGDLTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2S6</accession>
    <name>A0A1C1D2S6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phospholipid methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2S6"/>
    <dbReference type="STRING" id="86049.A0A1C1D2S6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03128"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05198"/>
    <dbReference type="eggNOG" id="KOG4300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT55109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="212" mass="22766" checksum="3C25A1712DA2F596" modified="2016-11-02" version="1">MAANEVQVKHIGELLSRAHGKVLELGPGAGDQMFHYKAEQLQVLYAAEPNAFLHGKLGEAAEKYGLGSKMVTLEAGAQPGSLLPALKEAGLISSTTSSLPDEGVFDTVVAVKSLCSAPQKQLAATVAVVQALLKPGGEFLFFEHVDNSTDTITISYAWLVDWIWPVLMGGCRLNGKLDKVVLGMGGWDERKITTVGDFKGHEVRLFLVVVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6N7</accession>
    <name>A0A1C1C6N7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase-like hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6N7"/>
    <dbReference type="STRING" id="86049.A0A1C1C6N7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00689"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01106"/>
    <dbReference type="eggNOG" id="ENOG502SJ1V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF9">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="289" mass="32455" checksum="D475894723500CA5" modified="2016-11-02" version="1">MALPMPRPTNPPLALLQYRVLSFDVYGSLIEYKAHILDAFQPLLSRLPSSSPFLNPEPLSSTIPDSATVGSIEFLKLFQRQEDAIKLEKPVKRFDQILQEIWRRVAKELNVHTSEDEARRFGSEDVIASWPTFPGTLDALKTLAKYFRLVALSNIDRYAWDITASSAASRLGEVEWWKVFTAEDFGGGGDDDDSSRADEAKLETLIKYCVEQEGIKKDEILHVAQSLGHDQAPAKRLGVSSVWLIGDGPRWGKEAESRMALEKELVGYAWRFQDLRAFADEVVRVAEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6P0</accession>
    <name>A0A1C1C6P0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">hmgA</name>
        <name evidence="13" type="ORF">CLCR_00630</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6P0"/>
    <dbReference type="STRING" id="86049.A0A1C1C6P0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00630"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01074"/>
    <dbReference type="eggNOG" id="KOG1417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="12">
        <location>
            <begin position="14"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="11">
        <location>
            <begin position="296"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT44138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="452" mass="50430" checksum="CB2BF5E5FC55F5CD" modified="2016-11-02" version="1">MAPVTDFAIKDNYTYLQGFGNYHSSEAIPGANPLVNNTPQRPPYGLRTERISGSSFTAPRDYNLQTWMYRATSSLEHEDFVPYDQESTATTTPTPKTPSTLTPNSYMWPAIPLSGSSDWLAQHLLARNGDPATKTGLAIWLFSTTESMKPNTVFSSLDGDSLIIPQSGALDIQTELGNLLVRQNEICVIPRGIRYRVTLPSGPCRGYICELFQGHFRLPDLGAIGSTGLANVRDFQVPTAHFDGSLQDGVAVARNAEYTIISRQAGRLWHCTQDHTPFDVAAWNGTFYPYKYDLARFCVLGNVAFDEHDPSLYVVLTVPSHREPGTAVLDFAIIPPRWQVAEDTFWLPYYHRNTMSEFFAPIITEQDKTHPFNGGREFKPFVAGLHPPMTTHGATEEDFEKARTADLKPTKLMTEGMTVFLLETESPLYLSDWAVEAALTNPRAKPRKPSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7I7</accession>
    <name>A0A1C1C7I7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7I7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06059"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07131"/>
    <dbReference type="OrthoDB" id="10555111at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="348" mass="39577" checksum="E7AD508B076748E7" modified="2016-11-02" version="1">MASSTIIKREEDSESETALADVSLPTSRAPGSPAAASTTTRRRANDLVFGTNRLATGFTAEDTKNKLEETQARLSSAIEEDEELRGLQNETQEKANEIEASLKDIKKEMTRLQESELQKQRLLEHYNEEIEHRAKQIEESDALIADLKGAVTQLEARQAFWERRRDETLPLVYLESQTFFNVMTNVTDEEFQNWLERVTSARAANRPRPESDAVANTATSSTDDNLNPVDDTTTDVLPEEDLVHDEPRETTKEVSKKRANSAFEAAVVAGTECAADDAPRRKHKSDWTPPAPSSFSKKHKRSHFPEKYRHLPQLSDEMRRRFMNEGRCFRCHEAGHRKNDPVCPLFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7R9</accession>
    <name>A0A1C1C7R9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_11198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7R9"/>
    <dbReference type="STRING" id="86049.A0A1C1C7R9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11198"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07264"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000024">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF67">
        <property type="entry name" value="MFS MULTIDRUG EFFLUX TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="52"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="553"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="633" mass="67741" checksum="C9D94F1056827D51" modified="2016-11-02" version="1">MMAPGPYPGADVIEPASPHATETTTLLPKSDVGKPRDVPYRDVISGPRFHFLFWSIIFGCTIAFFDTTLMASSHPVITSYFNASNAASWLSTVFYLTSTVFQPVFGRVSDNIGRRPVLIFVIVMFFTSTAWCGAAGDIGGFIAARAASGIGAGGVVSLASILTSDMVKIEYRGIYQSYYNLAYGVGNGLGAALGGFLCDKLGWRAAFYVQLPFIAVYGVLAVLSCPDNLGPNLAKTQGKTIREGFKSFDVYGTVGMILTVSGLILGVNLGGNVFSWTHPFVISSLVVAVIAGIGLVLVERRAERPILPLRLFTTTPVANVIGSNFVASMTVNAVLFNVPLYLQAVRQTSPTTSGFYLFPPLVGASITAIAVGFYITLTRRLKPPMIVGSISALGGAVAVTCLSADTPARLVPWLIPFVSIGQGAFFPAATIAVLALNSQEDQAVATTTLGLVRSLGSILGVALSSWVLQNALPIYLNKYVTAADPTAKEHIIRTVRESIQSIRHLDPVHKKQVITAYASSLRATFIVAIVFATISALLILPAHLPRLQRQEDMDDPEDGVYLPGDESNNETTFSVEDSDEDDDEEQALRVTPSRTITRTITGGTGHSGTRTLSRHSTSFGEPIERRASFDTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7V7</accession>
    <name>A0A1C1C7V7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative HC-toxin efflux carrier TOXA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TOXA</name>
        <name evidence="9" type="ORF">CLCR_05700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7V7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05700"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07221"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="50"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="542" mass="58216" checksum="3CB1EF9C314B59B9" modified="2016-11-02" version="1">MLAGTGPHSTTGTPASSPESTRSVLEKPTIAQVPVSESDYYLTGSKLYLVLTGIGLAIFLFALDVSIISTAIPAITVRFHATTDIGWYAAAYPLCLCALQPLSGKIYANFSLKWAYFVFVGIFLLGSLLCAVATSSNMFICARAVTGVGAAGIFSGALSILAIVVPLDKRALYTAALSSLFGVATVTGPLIGGALTTKVSWRWCFYINLPIGAVTLVALALFFRPPVRDSEKGSLREKVLKIDVVGCVLFVPTVVMALLALQWGGHEYPWKSATVIGLFCGAAVLAVAFLAWEWHEGDDAMIPFSILLQRSVLLSCLFIAFMMGSYIVNVYYLPEWFQVIKDATPLHSGVMTLPAVIAQVLATIIAGLIINRTGYHNPWSFIGMAFMATASSLYTTLDTSTGHAKWITYLVFQGVGGVAMQSPLLAVQAALASRPQLIPIGISTVAFFQYFGASVFQSIALAIFQNQLVSSLKSHADGLTQDQVQLLLDAGSGHARRVTLDHFPSKLQPVLWAYNKAITNVFVSFQFSFCADLRGFTVRPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C827</accession>
    <name>A0A1C1C827_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C827"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06487"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07327"/>
    <dbReference type="OrthoDB" id="4145309at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT44656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="84" mass="9233" checksum="8B8981C2269BC2E3" modified="2016-11-02" version="1">MKYAGAKKAARHEICKKDARTLYEKNLAQCDVKAAISLRGGALGLNWLEVGMVTATAVAWYYATSMAQGWLAARIPFLKKGQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C893</accession>
    <name>A0A1C1C893_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase domain-containing protein 2 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fahd2</name>
        <name evidence="4" type="ORF">CLCR_06060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C893"/>
    <dbReference type="STRING" id="86049.A0A1C1C893"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06060"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07397"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="53"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="266" mass="28053" checksum="70ABEBE6DBC522D0" modified="2016-11-02" version="1">MEAIDVGLAVRKGQDVAVDIFSGTSVLSPGQETGTTAIIDRVLSPLAATEVGTIRCIGLNYKQHAAEVNMALPTVPTVFMKPDTSLGHPWPAPTVLPKITQLDDCGDYEAELAVVIGKTAKNVSEADAMSCVLGYTACNDISSRTPQFAQSQWSFSKGFDGACPVGPALVSPLMIPDPSKLRVRGLKNGAVLQDCGTDDLIFSIPKLISFLSQATTLPPGTLIITGTPAGVGIVRKPKVTIMQGDEFHVEILPHIGTLVNVFANEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8J1</accession>
    <name>A0A1C1C8J1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rex4</name>
        <name evidence="12" type="ORF">CLCR_06108</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8J1"/>
    <dbReference type="STRING" id="86049.A0A1C1C8J1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06108"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07525"/>
    <dbReference type="eggNOG" id="KOG2249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="114"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="276"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT44854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="310" mass="34725" checksum="6FB01F99A6BDFF34" modified="2016-11-02" version="1">MDLNTLSANWKKLQATLKTSTTGTSPRTTPSQHGIKRKRDHSRRTTRESLAEAPKPRKRLRIGKSMAQNGNTSVQKMSVKEAENNDNVPRPRPATLTASDKVNAGLSPEVEIGRYVALDCEMVGVGPNPDRESALARVSIVNYNGDQVYDSYVLPLEPVTDYRTHVSGISAKHMKVARPLKEVQADVVKILQDRVLIGHSIKHDLAALMLSHPQRDVRDTSRHPPYRKIAGGSYPKLKILASELLGTDIQEGEHSSVEDARACMMLFRKDKAVFEREHSKRWPTPAPIQTQQEPDGPPKPRKHKKKKKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8W9</accession>
    <name>A0A1C1C8W9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_11218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8W9"/>
    <dbReference type="STRING" id="86049.A0A1C1C8W9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11218"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07647"/>
    <dbReference type="eggNOG" id="KOG0878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="131" mass="14916" checksum="7ECD31FBC4E69F92" modified="2016-11-02" version="1">MVSSAKHVPIVKKHKKSWFRHQSDRFKCVPSAWRKPKGIDNRVRRRFKGQMVMPSIGFGSNKKTRHMMPSGHKAFLVHNTRDVELLLMHNRTYAAEIASAVSSRKRIEIVAKAKALGVKVTNPKAKITTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C902</accession>
    <name>A0A1C1C902_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI-anchored cell surface glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C902"/>
    <dbReference type="STRING" id="86049.A0A1C1C902"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05377"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07604"/>
    <dbReference type="eggNOG" id="ENOG502RYYT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74412at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="945"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="751"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="972"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1181" mass="127682" checksum="5B7607DCBA9943DD" modified="2016-11-02" version="1">MSLNGLDGAAVAEALQAAQADAGGWFLLKYVNRDTVELLSKGTGGVPEVRALIQNYGEKSPLYGLVQYRRKKVVLKYVPDGTSRLLQVRLTVQFQSVLETFTPHDTVFSFAAASELTESALGLSTMLLPSAVSLTSSSSSLRRRRLNEISEDAEDVTILAEEDNEEEDEKEKPQGQNRLALDFLTPQPDETPLQQTPITTTAFGRRELDELPASAVLAKALLAKRKEEAAAAASALTGTPSSNVDSSQEKNLHPPRKDSLLASPKLSASPLPSPLPSIITDKSLPATPEPTPPSTSEGAPPAAPDFDATSNILLGATASTAADSSSQTTPRPHTRHLSAAESDSISLWSSNVTSYATAKPKKKKLGPRPHVEPTGRPKTSGTTDSSTGIRPVANLPTSIRVNNKSLVSLGLRPGSQQSTRSVPGRFATSSHSTTGAPPLPSPSFLQAPYSPGDSRSAIIRPASVTGEAFTATPEKVRLMKALQLRKRNMLLAQRASALSSTPSDVHGQNASESSLSTNTSSSRLSSIPSQEQLSNLDEESKLTQSSYTTSPTIMTNISEEPSTKASSVSEHDDTPHTRRSLSSATSSSLTPKASAEDEKTSAESTESACIRPSSSSTTSIAPIETEDDPHADVKVALAYLEAVPDKEPDTCVVEIRPQPSLEAQRSPPVVTSSARRSSPRKSRRLEPPEPLKLLRNSNASTSDLSEDDSLIDEIHTATVHEAKPISVARSPVTPIMSKGSSDRLREVVSKPPTTSHSTTRRSAATTPERGRSASGSVRSVSTALPQWPPLPAEPISAPLTKKATLGTGISKRIKALEVLRTKDASPPRQTIRETSAGTSAFSAFMKRSSFLSNQQQTPNASTDNSPPKILPTTGPQYDPHSSAAGRELRRPSVDTHRSSQKGETISVTARIVRDQNSKHPPLAPSSNYHAPLNLYKSPLIVEHEKHDQTSDQNLAANQPRVKSPTKSDRGRFSFSSHRSNSHTNLPRSDSNQSKISKSSNYKRHGPMSTSDTASIGDDKTRTSMTSRLMKRMSNLTSSRNKNHSPAKAESHQSQPSQDYQELTRENSIADSLLHVVDIGDVNVQFPESFLWKRRFMRIDDQGYLIFSQPATESNMKSASRKYHLGDFKRPTLPDYEREEMAWSVILDLKDGRCIQCACESKQFQQQVLQSELSSLSRSDPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9D2</accession>
    <name>A0A1C1C9D2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_05752</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9D2"/>
    <dbReference type="STRING" id="86049.A0A1C1C9D2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05752"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07787"/>
    <dbReference type="eggNOG" id="ENOG502SPEG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="540" mass="61212" checksum="B7F96F640E80ADA7" modified="2016-11-02" version="1">MSSGAAAIRPRKGRLGSRIKSNGGCLTCKIRKVKCGEEQPACLRCSSTGRKCDGYVNAINSREQPPAASASPTLADVGCIASYAHATRLEVQAFEFFMNDVLPGFSRIVDQHFWHQVIPQLSQSDKIIWDAVNALSCLIRHPQISWRWLLPGPKTSTLADDNHRLAVKWYSKSLHGLQKRMSHGSVSPGVLMVTCLLYISIECLQDNLDGAMVLYYRALALNNMLAEKGAGNYSTTATRDVGSVEGTVQSLLRHMSISKELPASLRKVNSHINMTFDSLSEIREEGYLLLDEVHEFLEHIDGIRIRMPKAWRPTPDLIEWWEKVRNRIRFLETAIQEVIKRQTRAISECPDEDELYSTLMLSFNHFYAVVSSSVSMYQTTLDEFMAQFRSIIAYARRVVAIQRRRSRRPVFVFETRILPALYYVATKCRHPLIRREAISLLENEAPRMEYIAKAEGMAVVAKRIVGIEEACGSEEGVFRAECPPHKADLLPAEDHRVYWERLTELVDATSGEPVHFLEYGIWRREGDGGVWTPTEHIVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAY1</accession>
    <name>A0A1C1CAY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_01390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAY1"/>
    <dbReference type="STRING" id="86049.A0A1C1CAY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01390"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03600"/>
    <dbReference type="eggNOG" id="ENOG502S6DU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3647690at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070823">
        <property type="term" value="C:HDA1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038609">
        <property type="entry name" value="HDA1_su2/3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021006">
        <property type="entry name" value="Hda2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11496">
        <property type="entry name" value="HDA2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="7">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="426"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="796"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1093"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="870"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1006"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1100"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1156" mass="129265" checksum="F3EB02D149CB01A5" modified="2016-11-02" version="1">MTKPVPKQPGIAEYKHSRRKSAIYSPWRDVPWDEQQALGGEFKEAGEGCWPVEKILEERINRRSNNRTEYLVLWKRHPTTRELWAPQWVWEEIDNRVIDDWKAEKRKKRKRGRLSHGSAVERPAKTRARVTRVLPNSSSQSERQGEEEEEEEEEAASTSVSNAFAASEEQRTPDLPSSSLEIAETQQEPFQPAHLVVDIPRATVNLEDYESLHSSQLHNSTSSIKYESPPVQSRRRPPTHPQPATLGIPSSSLSTGPEYVPSTLYDSLNPAKEQSSPLASSPHLIGSQSSPAGSPSKSPAQNSVIVSAEDLQVGRPTHKKPRSQTARSSTRFNNSSYRSTDGTPARHTPLFCSPSSLRRPSASSNSSFGDEFVVNSIESDAVQVTYIMDIDSITSTAEPAIGRTIAPQATIYDTALGGSALPIQDSIEDEEPSSNGEPSSSNSKTSSSQQSIENERDVAQIAGLVQPSLPILGPNEYVFTLPCEGKIQSTYADIIKAKEKSIKKFLSRHESIGSAHGSPNRTHERNEMNDMIQRLHDTVTHMDLGLPGFSTQYSLNSQEHAAYANYAGTKFLFLGYLVDFLHLVGVSIVIVSREGQIQDLLEQYLKMKHVVVRRQDRLARSKSPATDRLNTDFSVELVSTWSTHEVDLRSRPCLMIAFDASFDAQDPQVARIRAQFHSPPRLMPVLHLLVANSSEHVDRCLPKSLPSPMRLKALVRYTYSALPNLGGKPFVIQLDSDVPEGRPMDFSDLQKGVRKSPERKIAEIARIVGKAAVSPDFGTLFTLETPLLELTELHETPSMKPSRTTTRPETPRYGAARSRTPVSRADTPSGRKRLLDVDGVLPALNKRQRITPLRDSVELSSGAHEPNSKLTQLEEQVRKLQADLAAEQQARRIAEQDRDRAKEQLTEWQRDHASLQRRYEKRMTKCHELDREKTKLQKTVENNKSRHERTLEENASLKQKNAELQKELTAIREEIKAGGGDAAALETAREEARTLLAKTTYLEKSLENTRKDFEFTRSQYQNASNRATELAGQVTDLEKETAILAKQASDEKRRLKQMNFEKATDQHLAKIEQSELEGRSRDILLKKLEEENRQLKRNRGVQTRGSSVQPPGSPGLDGHGHGGRGTRSRQGSPAPGLFPSTHARAIDRGSLLRNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAY4</accession>
    <name>A0A1C1CAY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAY4"/>
    <dbReference type="STRING" id="86049.A0A1C1CAY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01604"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03610"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF8">
        <property type="entry name" value="S-TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="312" mass="34946" checksum="0699006160D04471" modified="2016-11-02" version="1">MSSTSLPAITSAQVPGIGAIGQQARMTLYTNHGCGWSHRVHIVLKELGLEYEEVLIDMDVPRPAWFLKLNPEIFSHADAAMKSSDNTANAKMQRGLVPVFQYTPTGSNQQFTLTESPQIVSFLTDLYPSHILPVLPSGLESWRTCSPADTAYMRYRMSFFVDTYFTKITPLMFKLVGADPGEPQEKIVDDILSRLREEIEPLLSDVDVDGKGPYFAGSERLTFVETHSGKVMTTPFVLRMIDFCNAVIFPSRLATAMLDTNPSTSNSPRFAKWAKVCIQHPSVTCTWDKEYMVPRIVERLPAAKRKYAPAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAZ2</accession>
    <name>A0A1C1CAZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_01422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAZ2"/>
    <dbReference type="STRING" id="86049.A0A1C1CAZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01422"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03550"/>
    <dbReference type="eggNOG" id="ENOG502RZG9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248252at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF2">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G04300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="496"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="761"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT45647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="860" mass="96444" checksum="92D2BDEF701586BA" modified="2016-11-02" version="1">MADKRPTGASPDELFSDDQSRASSTMDYPSDSGSNVIEESAEQLFTRLIDEHESDFKQKLRTLTSFAKILADDHAKSIKQLRRACKTYMTPETQHGQSMQSPRSRRPTAALDKEAARRSKIRSSATPATAAPAGQARTMRVSEEVARPLHARPQSGETGQNPPEHLFQDRHLSKGDQPRQTSRHLSQAPDHKTPNHESSLGHMEYHDDNADDDEAETMADIHHEEGLLPDNDAATTANIPHQMHPAASQTPASTPEPNIGGPDVGQTPKSGRCMTPKVKWAAEEEQRMIDIIHELSQATEQEGKKGDMWKRAEAMHRAYGYNRTWEQMAAKWSMQTRHKCELLGYTWAENVMKRVPHMPRKRRALSPDDQQSAQNDSPLSSKDRRVRKKSKKRLDAEATDSKGNRTPKQPHGHHSDLKLRYTFEGASSDIVQVDWSPDGQYFAAATNSVVDETSNFSNNRPRNLLYGSLPTKTIRELPEHRIERPKGQPHYVYTTVSAVKFGPTGHRMYTGGYDNKLRVWDVEDETQLGCKAELLYKNKRIEVMDVTGDQTTIVATGTHSGTRSVRVFIGDADLTADCKEIRPLREMGIDVFPYAPTCLKFGKGQSQNRLIAGFGQDTDTLDGTFGPGCMFVWEFAEAQSKAMSFDRGATFVSDCTWSPNGDFFVVGAVADPSSKQEPWEHSVVKLYSTTEQRTTMTFRCTARDINDVTYDFDLVTASCTDGSTYVWDRRNPRVPMHILRHGKPVGGYAQGLDRELNDVGVRYVEWTRNPGQLYTGGSDGFLKLWDTRRSQADVLLQDVVDIGNEILCGKFSPDHSSLVIGDEDGRLHLFGTSKTPLPREDFKFMLAERWAGQPERGSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB43</accession>
    <name>A0A1C1CB43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB43"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01689"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03579"/>
    <dbReference type="OrthoDB" id="10412740at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="270" mass="32451" checksum="2E9CC7B20680A462" modified="2016-11-02" version="1">MPRSDSSSGYFGEPERHGHQGHRSRDWTYSSNDSFSRPPSPSRDRDRRSNLSRDYTDRGRDLDSHRHTNLYRSGSVFNPQRGRYAWSSSNESDGFYAPTRIPRDSFHNRRHRRRLATYDGHEQGFYERWERALPRGQYRDDTELDYSWRDRFPVRRTDADAELDFLLEGRRDDMRRRQGRRESRSHYRDSTAADADYEDNEAGLPDGYRNRRERERSASRSWQGLCTGTRNFAIEYGLDVLQREYMDRRRELGNPADEGPRARRRRRRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBW6</accession>
    <name>A0A1C1CBW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_00444</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBW6"/>
    <dbReference type="STRING" id="86049.A0A1C1CBW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00444"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09998"/>
    <dbReference type="eggNOG" id="KOG3928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT46014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="495" mass="54988" checksum="D5A3434C384C127E" modified="2016-11-02" version="1">MSLSICSECLSRLRISTTPRRTLPIAAATWMQTTSFHTTAAQYKSPLLKKKATQQGSSAPRARQSQSARLKKKSRERPKLPPVGERRAQRRRIVLSNTNAIPVSNMETWSKDNVAEEKHIGQMMALDGGLLDQLRDSRAFKTTQNWCLFRRPATLIRQETIKVAKDMQDIESADGANRFVKRLVVGERASGKSILMLQAMSMAYMKQWIVLNIPEAQEHVNNTSSYAPLRHAETDTEQMYTQPHLTQLLLQRAVASNESVLKTLKLNHSHAKPLSLKSNATLYDLAQQGAADFHVSSPAWQALYKELSVPGVNPRPPVLVAADGVDHWMGPTLYRNSEHKIIHAHQFTLVKRFTNFLFSSPGTASPFVNGGMVLFSTSGSNTPAHPTFELLLSQMRAVQYQHMAPTDPDFPLPKPYSKPDEHVLALSGAATAHNNVHLMELKGLGREESRGYLEYFARSGILHQKITDGFVGEMRGLSGGGVVGELARLGRRAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC56</accession>
    <name>A0A1C1CC56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative HC-toxin efflux carrier TOXA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TOXA</name>
        <name evidence="12" type="ORF">CLCR_00404</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00404"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09974"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000489">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="130"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT46042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="628" mass="67008" checksum="CCBC9B4ACD29B283" modified="2016-11-02" version="1">MGLFSRKKDAPVTETLDVPTSDAAAKSETTTAVPSQNVSDTESLHKAQEVETGALDEKEAKEMDKSISTSESNTTVPSDGARLNTAGTKVTAGEHVQIQRTKSYNSVISGPGVEDDDAILYPGGLKLALITLALCLSVFLVALDNTIIATAIPKITDHFKSLGDVGWYGSAYLLTTCALQLFFGKLYTFYPIKTVYLVSIVIFEVGSAVCGGAPTSEALIVGRAIAGIGSAGIFSGALIIIAYTVPLVKRPVYTGIIGAMYGIASIAGPLLGGAFTDGPGWRWCFYINLPLGAVTMVVIVFFFQSPPRKAEAKVPLRERVHQLDLGGTALFIVDIIVCLLALQWGGSTYAWSSWRIILCLTLFGVLTVAFVIWQYFMKEFGTIPFNIISQRSVAAASWFAFTLGGAFFVLIYWVPIWFQAIKGASAFKSGIMCLPMVLALVVANILTGVGTTAVGYYTPFYYGCVLLSTIGAGLLTTFETNTGHEKWIGYQVIYGFGVGLGMQQALITVQAVLPLKDVPTGTALVMFMQTFGGALFVSVAQNIFNNRLISEIPKQAPGLNPQIILHVGATSLKDQVPARLLAGVQTAYNTALTETWYIAVAMACLSVLGAVFVEWKSVKGMKPGAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCB7</accession>
    <name>A0A1C1CCB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Shugoshin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_01092</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shugoshin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01092"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09350"/>
    <dbReference type="eggNOG" id="ENOG502SFX7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5394106at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011516">
        <property type="entry name" value="Shugoshin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07558">
        <property type="entry name" value="Shugoshin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin N-terminal coiled-coil" evidence="12">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Shugoshin C-terminal" evidence="11">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="213"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="494"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="34"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="535"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="695"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT46174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="733" mass="80784" checksum="B2A9CA120960E6E9" modified="2016-11-02" version="1">MAKLNEQPPAPPAESFDALKRRFIRQNREIARVNSTQSQRIRNLETEISRLVADNISLREQAIAAQAEAERWRAASSINNEIFDLRDRLQKKMEEVGELVGEMGRIPERVARKGRRKSRLTNVGQRWSSATEEEWRNRLSMREATAAEGELNDGRLPAIREDKLYPRRTLENAELSVLREEAAMQLTSESPELGPPPEVHFDVNEPIGMDLARTSELETGGEDTVQLPSMLERRRKRRTSALLQTMPPEEPAHEASEEPPQPQDLPVPKLGQQPLKSGAKRKLDASELDGPVIQQPQSEDDDFIFQRRQEVCKSAATGTKKGSRFTRPPGRENATGVQTEAQSPQKATIATRRILAPKSTNSPTKRRIHVSEKSKDGREEEAMQDAIRPVRRTNPPPQINTESLAKSADDRDGGEKDLLPKTPAGGVEGILSPLSTEPSARNPPQPKETAVLSSVEDVLNGSVGRGSRRARAAVSYAEPNLRDKMRRPGKELVGAVEGLERNKESTAGSRGASVDRNKSEDLKVNEDQCTVINIKQEKDADAESRWKDLPVRNNEDLASPLRDKERKERTNSDSKENAEAHNVAEALVKATDRLGIFDPPVSSPMEAVEEADTNRSGHPGPSTARRKPSANSLTTRRHSVQPSSSARSAADTDSRHGPAPEGRPSTVRVAPARPGSAASTRSEQMASIARDIKRSNSVNLKPKASETSSGGDPGSALSSRAERTLNRRRSMMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCQ6</accession>
    <name>A0A1C1CCQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative agmatinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_01168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCQ6"/>
    <dbReference type="STRING" id="86049.A0A1C1CCQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01168"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09263"/>
    <dbReference type="eggNOG" id="KOG2964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000014">
        <property type="entry name" value="Arginase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650713" evidence="6">
        <location>
            <begin position="19"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT46258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="380" mass="41559" checksum="A0ECABC99A828108" modified="2016-11-02" version="1">MFLLSLSVLLPLLPLARCSFYDNPELEIPTESGTPLDELKAKWDFDWGFSGISTFAHLRHVKCLTTPYEPFDIGIIGAPFDTAVSYRPGARFGPRAIRAASARQTSFRGFNHRAHLNPYTSWPAILDCGDIPITPFDNALALHQMSSAYLELLSRRPLSYSNPEGHVHPKLITLGGDHSIALPALRALEKVYGQPIAVLHFDAHLDTWHPGAYPSAWAETPTQADFTHGTMFWVASQEGLINNGSSVHAGLRTRLLGSDFHDYEDDEKQGFLRIESDDIDAVGVQGIIDLIMERMGTKTPVYLSVDIDVLDPGLAPGTGTPEPGGWTTRELIQILRGVEDLNLVGADVVEVSPAYESGHGESTALAGAQVVFEMLTSMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCY7</accession>
    <name>A0A1C1CCY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Phytochrome-like histidine kinase PHY1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_11242</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCY7"/>
    <dbReference type="STRING" id="86049.A0A1C1CCY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11242"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09140"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000048">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.270:FF:000002">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="442"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="819"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1261"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1065"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1154"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1418"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1076"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1154"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1168"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1179"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1191"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1242"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1418"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1441"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT46390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1450" mass="159508" checksum="437C3208427E51C5" modified="2016-11-02" version="1">MSRPPSREAAKPVADPDTSTLTAPSSSPAPHPTGSESPIRRGQQRPPTWVPLPPIPSQVSMFTGRSTGDPIVATPLSPKSDDGKAILSPGSIDRVFPARSAISIDPVATPMPRMDSSSGYPGMSVAARQRASSHTVSGPRPVPTTRTASVSDASEIGSISDAAQRSVGSIPQATGNLDHKILANMVTDDAVSRKSEASSISGGVPIPAQQGTGLVTARFKHVVTDEGHAVITGRDGETLQRCEDEPIHIPGAIQSFGLLIAFREENEKLVVRIASENSAKIIGYTPQQLFKIESFLDIFSEEQADNLLDHIDFIREEGAGDVASTGPDVFMVSIKPPHSRTRRLWCAMHLSETDAGLIICEFELEDDTTNPLVPPEDRVTPEFPEDTLGSQPTHEELMDSTVNISKPLRVLRSARKKRTEAAAMEVFNIMSQVQEQLATAPTLQTFLKVLIGIVKELTGFHRVMIYQFDHSWNGRVVAELVDPRATKDLYKGLNFPASDIPKQARDLYKINKVRLLYDRDQETSRLVCRTLEDLERPLDMTHANLRAMSPIHIKYLANMGVRSSMSISISAFNELWGLISCHSYGARGMRVSFPIRKMCRLVGDTASRNVERLSYASRLQARKLINTSSTATNPSGYIVASSDDLLKLFEADLGALSIRDETKILGNPRGHLQEVLAMVEYLRMRRMSAVFCSQDFSSDFPDLRYDPGWKFLAGVLFVPLSTGGNDFIAFFRRGVLQEVKWAGNPYEKFVKEGTEGYLEPRTSFKQWTETIVGRCRDWTDEEIETASVLCLVYGKFIEVWRQKEAALQNSQLTRLLLANSAHEVRTPLNAIINYLEIAMEGALDQDTRENLARSHSASKSLVYVINDLLDLTKTEGGQTLVKDEPFNLLQTIKDATNPFIGDARRKNLEYEVEISPSLPRSVLGDHRRVRQVVSNLIANAVQHTKEGKVIVEAYPCPTAQPQPGKTEIEIVVEDSGAGMSQAKVDALFKELEEVSYEEDLPESKAVITNPVPDQPQSENATLGLGLALVARTIRNMNGQLRVKTEEGKGSRFVIVLGFDTDGSDPAQLAIQPMSPDLSTRPATSSGQQEGEVTLIYRNPQKGPESLGSRPAPPPRRASAESMNSLASLKSAMSLKSDASRKSDADRLIDAIQQPLQFADQKTSSPAPTHDEAFRRRSLESPSKSKSLPSPRDLKSALRTGGWEKVKDSGTPLRPVRVPDDQEDEASGSKIGPRILFREPRSECSQSDTTEISKANPADNFSVLVAEDDPINSKIMKKRLEKLGHAAHMTVNGEECSSAFGEQPASFDAILMDLQMPIVDGFSSTKMIRSYEKTQGKSCLSSRAGQNGRVPIFAVSASLVEKERNKYVETGFDGWILKPVDFKRVDLLLKGIVDEEARNECLYQPGKWERGGWFSSREKQHDSYDVDTHPSQEKPTSVPGPASTSDEVQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCZ0</accession>
    <name>A0A1C1CCZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11245"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="279" mass="30549" checksum="F884299E79C4FF34" modified="2016-11-02" version="1">MALDLTSFEEVILATPWERGVYQCLLDKAGKGGVASPLRVDLELQGFDAIQSSWIVSAFEQHRAEKDAWKGPQSSGNRAKSDVECSIIGTSRKAWSQEPGLLVSSKAEYKGSYQCAFPLNCIALQIAGEMQILAAMSGSISNVHRYSIVTGYQPERADEGRELAKDNGDLLRYLALFCRTGFIGLTTSSYGHQANETGIQFVGVAGQGGATMSNPPVLRKGGFPMTMVDTTPTIIPLKALQFVPPISEFHRISEHARDQDTEWTQRLGSKSRRTQNLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD52</accession>
    <name>A0A1C1CD52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-1,3-glucan-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_01196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD52"/>
    <dbReference type="STRING" id="86049.A0A1C1CD52"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01196"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09076"/>
    <dbReference type="eggNOG" id="ENOG502QRX5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000178">
        <property type="entry name" value="Glycoside hydrolase family 16 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF62">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="93"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="440" mass="49811" checksum="511C8D35D5915699" modified="2016-11-02" version="1">MSQAIQEKSAQEHEYSTPPTAPRFKFNDSRNASSVAIHQQSLANRYFRSRRIGKDKIEKPWLEKKDPRQRWLSIFPLIGLLIGLALSGYLVYDGLASVETPVYCSVYEDDFTNGFDDRIWTKEVEVGGYGNGQFEETTNTDENVFVKDGILTIKPTLQDAHLIETNNVINLTANGLCTSDSWSSCVTSTNTTNGTIVNPVKSARINTKKGASIQFGRIEVVAKLPEGDWLWPAIWMLPVNDTYGPWPSSGEIDLAESRGNNWTYGMGGNNIVSSTLHWGPDGANDAWWRTNNRQHALHTTYADGFHTYGLEWTPTHLYTYIDTRLMQVLYTNFKTPFWQRGKFPVSDTNGTAFVDPWSQTGNPATPFDKPFYLILNVAVGGKNGWFEDGKAGKPWVDASPTARKDFWDAKDQWYTTWQDNSEMQVKSVRMWQRKGYGSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD60</accession>
    <name>A0A1C1CD60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metal tolerance protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MTP9</name>
        <name evidence="9" type="ORF">CLCR_01942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD60"/>
    <dbReference type="STRING" id="86049.A0A1C1CD60"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01942"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01188"/>
    <dbReference type="eggNOG" id="KOG1485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000012">
        <property type="entry name" value="Cation diffusion facilitator 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF11">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="163"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT46453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="451" mass="50503" checksum="9FC4BF7279EFA978" modified="2016-11-02" version="1">MVGKRTLNTTKTRADDRWRNPDLESGHHEQRRFAGFKDAVEYALDRRTTAALKEQLRSGVDRREFEKYRKSEEEIKKIKNKKIRKFYEKQNAVLNDWAEVDTIVLAMADEVLESMNTDADHDGIREREGRLQHVEEHIDALLPEDVRSARAKADRNARWAVNINVIANVILLVAKGIAALKSSSLSLIASLLDSALDLLCTVIVWTTTRLVSWRLSALARKFPVGRRRLEPIGILVFSIIMVISFIQILQESVEKLLPSGDHSIATLPALAIASMAGTVGIKGLIGLGCLRIKTTQVQALVQDCKTDVYFNTLSLLFPLIGKQAGVWWLDPLGAALLSLYIIYDWADTCLENVTRLCGLAVDDSLQKKLIYLAYRFSSVVSGFKSVTAYHAGDGVWAEFDILLDEKTPLRRTHDIAETLQYCCEALTEVDRAFVTTDYSAQNPGGHSQDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDP9</accession>
    <name>A0A1C1CDP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cutinase transcription factor 1 beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_01821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDP9"/>
    <dbReference type="STRING" id="86049.A0A1C1CDP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01821"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01390"/>
    <dbReference type="eggNOG" id="ENOG502RHAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4451586at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="652"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="706"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="829"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT46665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="877" mass="96602" checksum="9E903B24BAC5DC48" modified="2016-11-02" version="1">MSSLENPYTSTSSGPNATERVVKKRASQACHHCRTRKVKCDLVKSGIPCHNCSSDGIECVILESKRSRKYRLQKRQLSSLVSLPPISQAQPRSTSDSVSSYRPNHGPTDIDTFDGTTAPANQDAGALATEGLRTDVRSVHTTPIIPSFIPNSFQSPTAITPNTGVGAQSQVGATSTGSNRQQPAFELPAYIRPSRPDIRQDDLEFLCRRGALSIPVGELRDQLLHCFVLYVYPFMPIVDLEDFMGALDGNDASPKISLIVFQAVLFSATAYVDLSLLQEAGYENRRAARADYYQKVKLLYDFDWDVDRIALIQSLLMKNYWYVSENDQKDPWHWLGICVSLATSIGLNQPFTYTQKDPKTAALWRRIWWCCLYRDRVIAISMRRPMRIKNEDIRLSLLGLDDFETKSVTSAIPCLGDCDFLTDAYTRTMLAEMCMEKIKLLVFVGQILRDFYHLRGFGGSTAESTMLYTPRRSEVNSKQYLDLQHALDQWYRNLPPSCWLVTGNSNVDPDTSTADALLVHRSVLRMLYLMATEALNRPQSLSKPSGGSGNSPTSKVKEAAEKIAEMVESMQEKDLIRFLPPLSVSFMLLALASFLVDIKAKGQTVGALPGQQFHVCVRAMLRLREIWPIADAACFLIGQMITKHQVGKISTPGIQPTPMDASDAPTNVWRNPETPRPNDPTHTPAPLPYGDLEGATAVAFTSSAHDQPPFQATRDPGMVRPGMTAPISSSSSSSSASAAAAALAQENFAIPYTWTEEDFEGDYGSMIEAHALNMDLAMPDADVFAYFENGTFGFNFEPSPNNDHHVSNSTGGGSGGGHVDAMLASYPSQTQARGQAQVHAPHAPGQQRPSVSSMVGQSWNPAVASQYMETFRSSQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDV3</accession>
    <name>A0A1C1CDV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDV3"/>
    <dbReference type="STRING" id="86049.A0A1C1CDV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02134"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01433"/>
    <dbReference type="eggNOG" id="ENOG502SFSH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5336357at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="177" mass="20082" checksum="50B5969FB30EF4B7" modified="2016-11-02" version="1">MGTKRKAFIFEEDTLFYQQQSRAATPSLASSSPLSTTSTLQSSNGGDASPCDFHRVKAIPYLNSRTRKRHRDDRPNEEAIHENTLRKLYDAQRFHLDEVMHMSGVLELDHPCEHKEGEDEDAEMTDDLPEVELPLKIERNQRSIEAFFGGKGVGQPREPAKGMPETHQAGFWEAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEN1</accession>
    <name>A0A1C1CEN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEN1"/>
    <dbReference type="STRING" id="86049.A0A1C1CEN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02651"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02503"/>
    <dbReference type="OrthoDB" id="10666672at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="178" mass="19352" checksum="845688AA28AFD5A6" modified="2016-11-02" version="1">MAGSLATGVIGAGIDIGAHAAENQIDQDYANASVNANLVQGDSQEEVHGQGQDQGLDGDTTETDQAIPPVQHAVLTHPTYSTGEQTSYDTTEHEHETDDYGEDWEVYDDYYPEEAADGEHDYDHPGYYPDDNMTGYHQDHHGDPEHDTLDPHAEYGDPNVHAVDGHVFGGDAMNQSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CER3</accession>
    <name>A0A1C1CER3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CER3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02378"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02461"/>
    <dbReference type="OrthoDB" id="5345571at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057082">
        <property type="entry name" value="PH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057081">
        <property type="entry name" value="PH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23076">
        <property type="entry name" value="PH_FT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23074">
        <property type="entry name" value="PH_FT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="323"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="364"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="402" mass="45951" checksum="BA811B9122D51A8A" modified="2016-11-02" version="1">MDLLLREEAGRAQDISEILNTIRNNDLEDEQDITLAITGLNGLSWALRELNKQIDAVNGRLSKTFANDLKLLQQSVAFTLQDVWTILGRLPRVAIAADYQDAWKELVRYCTNMGKQTLDMRLKTYELFTCSLCKVLQRQSYSRAQFDDLRHDIYELQLLQREDRRLLKATEDFGRLELVPVPQVLRKPKSHERPRPEPQRPMSPTASNDSYETFQHKSAPSPPSLSPIATPASPVTTFSTLSRSSSVDPETKHWATKIFHNLPCTALAEDPSLSCCFGDVDGKRHRPPDAEYERILQLKFPGGLRTKFYWRPHDYRSKIVCECLNFTSYEWLVIFHCTVLSLRAHDTTSSFGNLHHDLDGEALKFAGAIRDSGYKHALRLYRDKGTGAIRLEAAVLDKEMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF08</accession>
    <name>A0A1C1CF08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Positive regulator of purine utilization</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">uaY</name>
        <name evidence="10" type="ORF">CLCR_02245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF08"/>
    <dbReference type="STRING" id="86049.A0A1C1CF08"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02245"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02322"/>
    <dbReference type="eggNOG" id="ENOG502QR1M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5373550at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14723">
        <property type="entry name" value="ZIP_Ppr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000006">
        <property type="entry name" value="Positive regulator of purine utilization"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="768"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="782"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="852"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="889"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT47103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1043" mass="115049" checksum="C47DD976C76B75A6" modified="2016-11-02" version="1">MTSSATSPQSAGLKRAYAADEPALPSHPEPAGAVSSNSPPPSSVASATSAFRNVSACNRCRVRKNRCDQRLPACSTCEKANVRCVGYDPITKREIPRSYVYYLETRLAYFEQLLKANAISYNAGEVFSAESKELRDAVQSPGSAKSSWLGPQSPSNGSPRPIRAEDWDKRQEDAEKLNKLVSNIGMVSVQGASDARYLGSTSGISFARVVLAAVKSSVSSNNSERAGVRPSRPMPNLASSGGSSMRDSYFGLQTKPTIKEAPFPDRALGEKLVNLYFEHANPQIPILHRGEFMHLFDRTYSIEPSKRTSRELYLLSIVFAIGAGIIWGSSDPQPNSREAEYAPKRARLGMQQAQPEEYHASAIVNLGSFLASSSSADAAERPNGDLEELQAVLLLCGFALLRPVAPGLWYIVGVAMRLAVDLGLHYEDGTGIDDNMEMQGGPRNPADKPLKPVDAKEKGRREWLRDLRRRLWWCTYTFDRLVSTCVGRPFGITDQVITTEFPSLLDDKHISRAGFSRPAFPDEPTYKWVSHHYFRLRLLQSEILQVLQYQQAQQARLGGTNQRNQFMHTKLPSPFLSKFDSFRSWRRDIDQRLYEWKESAPDPSETGVGFSVQFLELNYWQAVIMLYRQSLSVPAPLANELSPTEDVASPSSVRMEEKEDEDLVFLKCAEAGQKTLKLYRQLHRLRLVNYTYLATHHLFMAGISFLYAVWHSPAVRARLTLDDFDFTVLAATSVLGDLMEKCPPAEACRDAFERMSKATVQMCMSTPGFGFSMEPRDERQPRQQQLSRQTSLQNQPQSQPVPMQIDPKPPATTRIAPRPIQKKRPPPKFDMDLRELFPEDLEPSTRPSYSFPQPLQWMRQQQQQQHSPQPNTNAAVGMGLGPPPHAASLQHSPTQGQMSPASSINSQINTGLGMGPSSTNPQLFSPQPTQAQANAQFYMQNTYNPDFMSSLPGMDFLNSMGGDSGAGGEGDFKIDAGGLGDLGFGMGLDLQHDWSDGQQYDLFDGFFFGNGNGTANGNGNGSGNGYEGAGGGGYNAGEGTGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFA5</accession>
    <name>A0A1C1CFA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFA5"/>
    <dbReference type="STRING" id="86049.A0A1C1CFA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02494"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02217"/>
    <dbReference type="eggNOG" id="KOG3117">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="385" mass="42784" checksum="363ACF85885F8D57" modified="2016-11-02" version="1">MTVEDQTSTLLATLTTALESAASAFPDTEQQFLPPSEGISLLDIKNDLLLSYLQNLVFLVVLRLRNGYSEDSGDITSDVVKKLVELRIYLERGVRPLESKLKYQIDKVVRAAEEADRRTAQKVTAKQKKSKEPTTKELAGDVSDEFDSDNAESDEDHDAPEKDVTNADFSAAPRPAALLQSAGAMKKEAATSKSRSTASGAYKPPRITPTAMPVPATQRDRDAPARKRKSQLLDEYIDEELSTAPRAQPSIGSNHTIVKHGRGAMSTRDRENERERAEYEERNFVRLPAESKAEKRKARLRGEADSRDLFGGEDWTGLGGLGDRINRTVAGRSREEKTSLLERRQKRGRDTQDGPRGDGVGLGESFEKRRKVMQQRLDKKSGRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFD2</accession>
    <name>A0A1C1CFD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02453"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02195"/>
    <dbReference type="OrthoDB" id="4153359at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="416" mass="45659" checksum="9105CF1B3A613D05" modified="2016-11-02" version="1">MAPQQTNDNPDNTALAISPALIVGIVIIAAFFCTLIFASLYRFCGRRSSNGLTSEAFAARDTDNVVGINAGGEFWNPNRQRSAAQIARMKEVRWINNMYAWERGRHARLEVGEIRPTTMIMGRKGENRSWDEYTVAEDSSGRDSSGHASGDHAGPYFYNTENPYGRFASQQRLSHLAPSTNGVRASYLSSGNGSGLLPRQPSALLPPPINEQPGTVLRRSPLRHEYQVEGTARELPTQPRTSHPTITVNDRTQNFPELYSPAYAEDTNFETISLRDESPSGGQGGRGSVDPAQPPANFSRPREGHNATPTQRRSVVVTDGSLPQLQLQFPLPQSHSQQTVSSIYDEDEGVDVNSQSETIPLSGCAEVQDLEESTPLKEVQSPEDDGQDVGGTVAKENVKDMIQEWERVNGRFGRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG95</accession>
    <name>A0A1C1CG95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter CDR4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CDR4</name>
        <name evidence="12" type="ORF">CLCR_03239</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG95"/>
    <dbReference type="STRING" id="86049.A0A1C1CG95"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03239"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01832"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="927"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="963"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1047"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1152"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1590"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1621"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1664"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1710"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1745"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1865"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="565"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1236"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1892"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1905"/>
            <end position="1919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT47553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1919" mass="213015" checksum="AFE7E5ADDD5AD669" modified="2016-11-02" version="1">MSGTVAPPLPNIEPVLYAVQPGNHFADGELSINSDAPVANGTTVVESSSSKLSVLEISVRESLVVEAAPSETSNKILEIIFDYALNKFSDTRQQLEAGRPKFLAVIEKFVSAGAQVETCLPAFPFNLDFAFGSGIAKGYQMRDESTSWSAINWWISRLTPPISRSANKVYKVLGTLPDKAEEIALKRLNDMCLRIGEIYAPGARCTIISDGLVYNDLLSISDRDTWAYGQALRAMAVQKGFDRIRFSRIRDFVNFPLPEKMDEITYVANATNFRRFILNNFGKDDIDIDHEIATKPDTKLTYLGYRRFLESDLKYIFPVGNGRSNHGYKRDVKYLAKEMLVRGHAFAGAVAHAFPNYLRLSIHQSTGEHKVSMSLLNTKTGFTTPWHCSVALMADGEWVSAPMGEFKKDPKMKLVYEDGRPSYFQETIGNGASHQHSAGHAVEASEDKSLVAARQKVEYIMTAPSSMTEIDVDKVNVLAKVASLGEAKDGKSEAVNPFSGSRNPQLDPSSAEFRVRAWLEAVMNIASRDPERYPKGVAGVAYKNLSAHGLGNPMDYQKTFGNYAIVLLKWAKRLLGTETKPRVQILRDFDGLVKSGEMLVVLGRPGRQTIAGETDGFYIGKDSYLNYQGIPKETMHKDFRGECTYQAEVDAHFPQLTVGQTLDFAARARASRYDPYVMYAAHLRDVVMAAFGLSHTVDTIAGSDFVRGVSGGERKRVSIAEVAIGGSTLQCWDNSTRGLDSSTALEFVRTLRTSTSLTGATALVTIYQASQSIYDASLAYGNKVFDKVAVLYEGRQIYFGKVHEAKRFFVSLGFECPPRQVTADFLTSLTNPLERRIRPGFEGKTPSTPDEFAACWKQSEDRARLLRDIEEFDRQYPLGGASLDEFKKSRRAVQAKSQRIKSPYTLSVPQQVTLCVRRGFQRLRGDMAIVLSGAFFNVIMALVIGSIFYNLRNETGSLYSRGALLFFAILLASFASALEVMTLYAQRPIVEKQARYAFYHPFAEAIASMICDLPNKVLTSLGFNLTLYFITNLRRTPGALSRSLPEALVPASLFSLALAIYTGFTIPIKDMHPWFRWLNYLNPVAYAFEALMINEFHDRTIECSRFIPEGPGFGGVSPNERICATTGAAAGADVVDGDTYLAVNFRYYVSHLWRNLGVMIALMIFGCAVYLIASEYISAKKSKGEILLFRRGRVPYIPSKADEEANTGNGISTDILRHERPVLHAPSGLQNQTAVFQWSDVNYDIKVKKTTRRLLHQINGWVKPGRLTALMDDQEAYAPIQGVTGAGKTTLLDVLASRATLGVVSGEFLVSGQPRDTGFQRKTGYVQQQDLHLATTTVREALTFSALLRQPRTTPHAEKMAYVTEVIKVLEMEPYADAIVGVPGEGLNIEQRKRLTIGVELAAKPALLLFLDEPTSGLDSQTAWSICTLLRKLADNGQAILCTIHQPSAHLFQAFDELLLLSIEGKTLYFGEIGKSSETVTGYFERHGARPCGGRENPAEWMLEVTGTGATTTGSGGAKDWSAIWSESDERRAIKTELARMKSDFAQQPVSVNDPSDPDALRPFAAPFGVQFWTVQKRVFQQYWRTPSYLYSKVALCLLSALFIGFSFWKMPNSLQGLQNQMFAIFMLLVIFTNVCSQIMPHYVAQRTLYEARESPSKTYSWKVFVLSMTIVEMPWNVLSAFLIFVSWYYPIGLRQNAVEADQGAERQALMFLFILAFLLFAGTFTNMVMAAVDSAEAGGNITNLLHSLSLIFCGVLATPDALPGFWIFMYRVSPFTYFFSGVLSVGLANSRISCATEEFLHFSPPPALNCSTYLAPYIEAAGGYLTPDSMGSTAECVFCSGHDTNVFLESVSAKYEDRWRNFGIFWSYIVFNTAAAVVLFWLRRVPKGKRVPQTVETEAEAQETDERAKAKAKAKADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGE9</accession>
    <name>A0A1C1CGE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor SLT11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor slt11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">slt11</name>
        <name evidence="14" type="ORF">CLCR_03558</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGE9"/>
    <dbReference type="STRING" id="86049.A0A1C1CGE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03558"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01791"/>
    <dbReference type="eggNOG" id="KOG0153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12265">
        <property type="entry name" value="RRM_SLT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000396">
        <property type="entry name" value="Putative Pre-mRNA-splicing factor slt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034356">
        <property type="entry name" value="Slt11_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="232"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="156"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="328"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT47595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="381" mass="41817" checksum="43FEC8875B58BC33" modified="2016-11-02" version="1">MAPPQIKQDLNRSGWETTDFPSSCENCLPDNPYVQMLKEEHGAECKICTRPFTVFRWKADRTARTKRTNICLTCARLKNCCQSCMLDLSFGLPITVRDAALKMVAPGPQSDVNRQFYAQEHEKEIEEGRGAVEAYEKTDEKARDLLRRLANSEPYYKKQRRLEAEGTQSEEQPKQQRQSGYGPGPGPIRTADSRKAAAQRGTKTGPGGARLVTAARPPQPEDWLPPADPNITSLFVTGVEDDLPEHAIRTFFTPFGQLRSIVCSHRAHCAFINFATREAAEAAAAHCQGKAVIQGCPLRIKWGKPKPLDNTDRDQRMAWAREGRDQAGAIKQQQQGGQRAVAAGDQQALIEGAGADGDTASFVVAPPPGQGEAKYASLAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGN4</accession>
    <name>A0A1C1CGN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WKF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGN4"/>
    <dbReference type="STRING" id="86049.A0A1C1CGN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03567"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10400"/>
    <dbReference type="OrthoDB" id="10261563at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="2">
        <location>
            <begin position="155"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="389" mass="42923" checksum="FF42CE604467EE71" modified="2016-11-02" version="1">MGQTIIPAWKRLGLKLKFAQEVPETPPVNAKVATETQATFIGSEDREHNTIEPPRKKRKTESKPKETGRHSPPASKPSQDPTTNNEVPSGVNLKKQVSFTADTKGESATTNGGPSPSESSNGEAQASTAGKKQPKKKAAKNSQQLPVQKANTALDYLTQYNVARPSWKFNKNRETWILKHIFSESDIPRDYDLALSRYIHGLKGVGARERLKKQCMEFVAKENDRQNDVNEAGQSSMSGRDEQYAQRFKSELGISTTSDSAHENNADQDPEYRSWIRAQPRPMLLLLAIALEGDSLHRDGLGPRSEPEQARGAENTPRTKVKKRKNRTAVVDYDSSSSSSSSDSSETESESEGESEQRDGQMTNDQTLEDETSSSGSDSESSSDDVYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHX9</accession>
    <name>A0A1C1CHX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_04141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHX9"/>
    <dbReference type="STRING" id="86049.A0A1C1CHX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04141"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08221"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="322" mass="35066" checksum="582988653EA6DA24" modified="2016-11-02" version="1">MSSSLTSIFAGLVSWGVSHTNNEHFASWRIFLLTIGLVTIVVGVIVFFYLPDSPVKARSFTDAEKVATLLRVKDNQSGTQNAHIKKSQILKTFQDPGVYLVAVSVVLLSVPTAIPNFSSILLTTFGYTSQEALILNIPGGVVGAISTIVIGYLSDKWNDRSLVMIISILPTIAAFAMMIGLDPGGVPKSKGALLFALYLCNSFTSAFMLLLVWNASNLGGHTKKVTVNALTLMLYCAGNIAGTESFRASEAPGYISGKAAIMATLSAQVLVCLVLRFRNDRLNKKNREKLAAMSEDEKERLRQQLAYADKTDRENPFFVYTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHY5</accession>
    <name>A0A1C1CHY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exportin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xpo1</name>
        <name evidence="9" type="ORF">CLCR_03823</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHY5"/>
    <dbReference type="STRING" id="86049.A0A1C1CHY5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03823"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08272"/>
    <dbReference type="eggNOG" id="KOG2020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000490">
        <property type="entry name" value="CRM1p Major karyopherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT48120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1072" mass="122496" checksum="142E868229468696" modified="2016-11-02" version="1">MSVTVTELDATVKAFQEGHGEIQKQAQQKLNEFKSNPDAWLMVDRILQEATYVPTKYLGLQVLDDVVNTRWKVLPRDQCLGIRNFVVNQILQASETDESLKANKLFLNKLDLTLVTILKQEWPHNWPSFINEIISACHTGLSVCENNMTILRLLSEEVFDFSQDQMTSTKAKNLKTTMCAEFSSIFQLCNEVLTTATSISLVKATLETLLRFLNWIPLGFIFETKLIDTLVGRFLEVDEFRNIALKCLTEIGGLQLGQQFQYDDKLVQMFTETLTVVARTLPLDTDFRDAYAKAKSREQEYILNLAIFLTNYFSAHLQTIERLPNPDYLLHGHFYLIKISLIDDREIFKICLEYWNKLVQELYEEMQQLPITELNPLVSMGVSGLANGGAPHPSSLANYPLRKHKYAQVLSSLRQVMVEKMVRPEEVLIVENDEGEIVREFVKESDTIQLYKTTRECLVYLTHLDVVDTENIMSDKLQRQVDGSEWSWNNCNTLCWAIGSISGAMSEETEKRFLVTVIKDLLGLTEMKRGKDNKAVVASNIMYIVGQYPRFLKAHWKFLKTVVNKLFEFMHETHEGVQDMACDTFIKIANKCKRHFVALQPGETEPFIDEIVRNMRKITCDLTPQQVHTFYEACGYMISAQGQKSVQDRLISDLMSYPNQAWDSVIQQANSNPAILHDPEIIKVVGNIMKTNVAACSSIGSYFYSQIGRIYHDMLNMYRASSQLISDAVASGGNVQTKTPKVRGLRTIKKEILKLVDIYVQKADDLPMVNESMVPPLLDAILLDYQRNVPDARDAEVLSVTTTIIHKLHNLMDDKVGPIMDAIFECTLEMINKDFHEYPEFRVEFFKLLQAINLFCFPALLKLDGRQFKFVIDSCMWASKHDNREVENTGLSMCLELINNMAETDPQTSGIFFQQFYISILQDVFFVLTDSDHKAGFKSQCMLLARMFQLVETNKISQPLYQPDQAAPGTSNKQYVSEFTSNLLQRAFPNLKEIQVQLFVSGLFTLNEDATKFKTHVRDFLISLKEFAGDNAELFAEEREQEKKALADAERERGLKVGGLIKPADLDGDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIQ1</accession>
    <name>A0A1C1CIQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04383"/>
    <dbReference type="OrthoDB" id="4155194at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="180" mass="20508" checksum="C4A1598A62108C63" modified="2016-11-02" version="1">MAQDHISLAQSCVAPDSEPMDWKVEDACNEKGESESSLARSRHGEDCACAWRGIMVNNSQNRISITTLSNQNHKLQRVQAQRKRTSDGSIKGEQDRRVDDATPALLQAYKDGQTNNIRLQVDMDILRRRITAMRVQDREGNLPVSQYEYAAASKQRLERASERASITGHRLREWNEDVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIY7</accession>
    <name>A0A1C1CIY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase reductase 3b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SDR3b</name>
        <name evidence="4" type="ORF">CLCR_04235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIY7"/>
    <dbReference type="STRING" id="86049.A0A1C1CIY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04235"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08563"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="307" mass="32879" checksum="580D1F732C5BF0E9" modified="2016-11-02" version="1">MANEAFTISRDKLTGPRDSTILVTGGSSGIGLQTVILLHELGNNVIVVDRARPSPAAPTSLTSSPRFLYQQCDITSWKQQRAAFEAGVQKFGSIDCVFVNAGIAEYKDQFFKDELDADGLLKEPDRRVVDIDMHAANDTAKLAIHYIRKKGPEKKRGGSIVMTASLAGYLASAGAPLYSAAKHGIVGLMRALKNDTATLGIAVSVVAPGITLTDIISGRKPGESLSDWAQRMRALGVPINDPQEIANAVVYLMSLGMEGNGKGLLIQAGRVADLEKGIATSRKIWMGTEMLDLFRGGRNAPLFPNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJC8</accession>
    <name>A0A1C1CJC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotransferase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJC8"/>
    <dbReference type="STRING" id="86049.A0A1C1CJC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04146"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10302"/>
    <dbReference type="eggNOG" id="ENOG502SN24">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="91"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="317" mass="36563" checksum="CA088E65BF1F0A90" modified="2016-11-02" version="1">MPSLSRDRPGSLTQKPPEQERKGKERMRDLDFPISTPYFAPTTVLPTKLPSTAEIESAREILTERTAAKVVALGPHFVAKYGRGIDLEEGQTMIFVKERAQVPVPTVYALYHDEGKNFIIMERIHGQTMEERWTTLTGAEKNLVATQLKECLRRMRSVKPMNGYSSLNQKPLRDSLFLTYTGEGSRKYHYEGPFKTESDLNDAIIRKCKASEAMRGKAMFYQNALHDVFCTHPPVLTHGDLQRKNIMVRTGPQGKGDVTITILDWEIAGWYPSYWEYAQAIVACGLFEDNWHHFVDRFLDPYRNEYAWLHMLQNELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJM6</accession>
    <name>A0A1C1CJM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosducin-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PLP2</name>
        <name evidence="4" type="ORF">CLCR_05108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJM6"/>
    <dbReference type="STRING" id="86049.A0A1C1CJM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05108"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03228"/>
    <dbReference type="eggNOG" id="KOG3170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903333">
        <property type="term" value="P:negative regulation of protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="67"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="241" mass="27590" checksum="0D5AC94A8AD13C93" modified="2016-11-02" version="1">MDMPVNVPIDNPDADTEWNDILRKHGIIPEKPPDPEPIIQEALLEAAKRAHENRLEDKDLDELHDLEDEEDEAFLETYRQKRLAELSSLQKKSVYGQVYPLQKPDYARDVTEESSKAFVLVNLTSSTGTNVESRVLSEIWREAARKFGDVKFCEIRADMCIEGYPDRNTPTILVYRDGDIKRQIVTLGQLSGARTKLKDIERLLVEVGALQDSDVRLKRKGEDDSSSSSRDNRDDDDDDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK85</accession>
    <name>A0A1C1CK85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative amino-acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_04708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK85"/>
    <dbReference type="STRING" id="86049.A0A1C1CK85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04708"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02998"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000046">
        <property type="entry name" value="Amino-acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF29">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="574" mass="61873" checksum="2B2A9996AB5F9104" modified="2016-11-02" version="1">MSAERNFSTASQTHRRSVAEEPVTSVLAGTEVPVFDRELTADEEVLAALGYKPEFKREFSLWTSFCVSFAVLGLLPSFASTLWYGMGYAGTPGMAWGWLIAMGFIQCVAMGMAELCSSMPTSGGLYYASAVLAPPGYGPIAAWITGWSNWLCQVTGAPSVNYALASMILAAGSINNPDYVPQNYQVFLLTTLIMIIHACISSMPTRWIATFNSYGSTFNIIALVITVITIPAATNRTSQGLPRFTKSSTVWGNFYEGTDYPNGVAVLMSFIAVIWTMSGYDAPFHLAEECSNANIASPRAIVLTSGVGGLMGWFLQLVVAYTVISIDDVLDSDLGQPWASYLLQILPKNTALAILSMTIICGFSMGQGCMVAASRVTFAYARDGCFPLSRYWAHVNPITKTPVNAVWFNAVIGILLTLLLFGGEACIGAIFSVGAIAAFVAFTIPITIRTFFVGSRFRRGPWHLGKWSYPIGVASTCFTLLMIPILCLPSVTGKDLDASLMNWTCLVWGGPMLGALVWWVVDAHKWFKGPKVNIQHMMLGRGDNVLEGKDQGSDSGSGISPAVLIGADKADTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKF1</accession>
    <name>A0A1C1CKF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_04797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04797"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02917"/>
    <dbReference type="eggNOG" id="ENOG502QWBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="499" mass="55164" checksum="E61960272A0A4A03" modified="2016-11-02" version="1">MMPEEAQLDRDEEDATESASLLHAAHHGDNRKDEPRSTSKLLLRIYLIVFCLSLGTQILQPAQIQVFESIYCSQWYQRHPIDELPSHGHIPESYCKIAQVQTQISTLKGWLEFFNAAPGLLLSIPMGILTDKIGRRHLIILNLSVLCLTQAWTTFVTWFGGRIPLRAIWLGASLNLLSGGGIVTELLYVCILTDISPRDQVAETFFRTTAFGQFSKVLGPFMAAALMRFDPWLAVYCGLAFLVISVILATAVPETLHWRTKRQDGQSQSHEHQGGQDSNSAARKPRLLALRHLLKVWSDWRLVFVALTYPFRLVCYALGDMLQRYISDRYGWTLADATLIYSVQAVAAGLVLFTVLPLISGHIDRRFSFSIVQKNVVLSRAALLVMSVAYALIGLAPTVLLTFVGLLIETLSTGFPATLRAIATALVGDADRGRVFSVLGIAETLSIMMAYPVTAALFNIGIEKGGGPWLGLPYDVISVAASVGFVAMCLVRFDRPVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLI6</accession>
    <name>A0A1C1CLI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_04715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04715"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03297"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2351791at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000786">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000018">
        <property type="entry name" value="Putative MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF59">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="583" mass="62334" checksum="6B0AEA2DCFC12720" modified="2016-11-02" version="1">MSVPTTDATPSVAAVTREPQSGSAAAQPSQTTSSSSSITSQEARVGEKDDSAGPATEFTISTRFIMAFAALAVLTLMVALDGTSISVALPIIARTLHGTAIEAFWAGTSFLLASTVFQPNFASFSHIFGRMPVIMVSIAFFFVGVMMAALANDFGLLLAGRSIQGIGGGGIIAMTEIVVTDLVPLRYRGQWAGIIAAMWSIGSVSGPVIGGAFAAVQWRWIFWLNLPFIGIGAVMVPLFLRLNVIPQSIAAKLRRVDWIGTVIFVGSMTSFLIPLTWGGVMYSWSSWRTLVPLLVGAVGLIAFCFYEAYVAPEPLLRFAVFGNRTVNLGYVTTTIHGMILWCLLYYQPLYFEAVKGYKPVISGVALFPATFTVAPMAVVTGLTITKFASYRWAIWSGWAISTLGLGLLVLLKVDTAIPAWIFIDLVSGIGLGILFPGLQFQVQAASQNKDMAFAVAMFVFFRSFGQALGVAIGGVIFQNEMVTNLKAYPAYAGQASELAKDAAALVEIIKNTESGLGKLQLRTAYTDSLRTVYIVMAALGGVCLAASLFIKGYDLNVGLETEQGLIVEGKKRKEKEGEVKADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLK9</accession>
    <name>A0A1C1CLK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ureidoglycolate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_05105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLK9"/>
    <dbReference type="STRING" id="86049.A0A1C1CLK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05105"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03328"/>
    <dbReference type="eggNOG" id="ENOG502S1JQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20298">
        <property type="entry name" value="cupin_UAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047233">
        <property type="entry name" value="UAH_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221">
        <property type="entry name" value="UREIDOGLYCOLATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221:SF1">
        <property type="entry name" value="UREIDOGLYCOLATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT49415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="264" mass="28010" checksum="695C42BF06F352EC" modified="2016-11-02" version="1">MTPPTLPPPSHSHVEHLSIEPLTPSAFAEFGTAISPPFPPTLTHPPGSVDTIPPPVHAPHQPAAVLANQNSALKTSPISQFVNNYARSSTPQRATPQMSMFSCFPRNLSGIGMDTSPSSRGEWAFKVDILERHPYTTQTFAPLGLSASSDAGTIFLVIVAPSLPGSIAAATLPDGSSKTVTNPPALSRLRAFLARGDQAVTYAAGTWHAPMVVLGQKRVDFLVTQFVNGVAEDDCQEVLLGRNSVRVRLSGLRPQNGKRGPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLX1</accession>
    <name>A0A1C1CLX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HMGR</name>
        <name evidence="12" type="ORF">CLCR_06581</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLX1"/>
    <dbReference type="STRING" id="86049.A0A1C1CLX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06581"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09768"/>
    <dbReference type="eggNOG" id="KOG2480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025583">
        <property type="entry name" value="HMG-CoA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13323">
        <property type="entry name" value="HPIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="239"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="638"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT49506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1149" mass="123479" checksum="C65936EA2EA2A4FE" modified="2016-11-02" version="1">MVRGSSLLPKQLRSLGKSDGWLNRTVTSNLLAVSSLACAHPIHTVVAIALFASTSYVGLLQESLFDSGLKSLQQNGRVDVEALLQGSRTLELSEKTAWKWQFPEDSSVPQVSLGPNHYAISTFVFPDSSSNQLAPDVTAVSTPANVTAINIPTTSNLLSPISHDTSLAFYTSFSELADFLRTAQELPAQQARSEEQRKPSWFMKAARLNGNGPRGAYTTWFREGWTSFVDLLKHAETLDIIIMSLGYLSMHLTFLSLFVSMKRLGSNAWLAVSVLFSSLFAFLFGLVTTTKLGVPINMVLLSEGLPFLVVTVGFEKSIILTKAVLSASYDKNRRSLENGSANGGANGPVVAPNSPSSIQDAIQIAVRETGFEIVRDYAIEIAILILGAASGIQGGLRQFCFLAAWILVFDCLLLFTFYATILCIKLEINRIKRHVALRKALEEDGINQRVAEDVATNNDWPTGQSGQAAGFNIFGQKIKANSVPKFKIWMVTGFVIINLVNLCTIPFRTAKAPGAAMPSVLTPAPIDPFKVAENGLDAIYVTAKSQKQETYVTVLPPIKYELDYPHLPRADAADDLGFFDTDYTDQLLNVVGGRVIEGVLSSLEDPVLSKWVLIALTLSLILNGYLFNAARWSLKEPQSTTSSPAAQKAPELELPLTPKPRRTTVTAPAQSQRSPAEREQMLKEKKAAYLTDEELIDLSLKGKIPGYAIEKTLENAEVMSRREAFVRAVKVRRAVVSRTPATKHVAAGLEISKAPYKDYNYELVHGACCENVIGYLPLPLGVAGPIIIDGLQYFLPMATTEGVLVASTSRGCKAINAGGGAVTVVTGDGMTRGPCVGFPTLVRAGEAKVWLDSDEGQQRMREAFNSTSRFARLQSMKTAMAGTYLYIRFKTTTGDAMGMNMISKGVEKALSVMATECGFEDMSTITISGNYCTDKKPAAVNWIDGRGKAVVAEAVIPADVVRNVLKSDVDALVELNVSKNLIGSAMAGSIGGFNAHASNIVTAIFLATGQDPAQNVESSNCITIMKNLNGNLQISVSMPSIEVGTIGGGTILEAQSSMLEMLGVRGSHPTNPGDNARKLARIVAAGVLAGELSLCSALAAGHLVKAHMAHNRSTVPTRATTPVSAAVEPFLRAQNGPSIPSSLKMTTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM07</accession>
    <name>A0A1C1CM07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM07"/>
    <dbReference type="STRING" id="86049.A0A1C1CM07"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07530"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09746"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="260" mass="28822" checksum="9D76DCA35A669B53" modified="2016-11-02" version="1">MTDMSYVECMKSLCSTGLHIVQERSISSDLHWEPSNMLKVQEEFANILRHAAPHLRDVTNCRSIRDQLEHWCFDLHISFFTSELFRPLLKHQKPNAEQLIQLRDICIESLAKTVHAFLGLQNVASSVKTSWAVLQKALSSALMLSILQEPLRDKRVKSLLDGFMAVMMDLNSGLGPSELPAPLSRSIAALQRLLALPANSNLSASRIIHHQLEPGHDIEELANKTKSPHSMSSSSQSGGSPYTLRDSILWGGPGHGMTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMT7</accession>
    <name>A0A1C1CMT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable 26S proteasome regulatory subunit p27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PSMD9</name>
        <name evidence="6" type="ORF">CLCR_07578</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMT7"/>
    <dbReference type="STRING" id="86049.A0A1C1CMT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07578"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08761"/>
    <dbReference type="eggNOG" id="KOG3129">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000107">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="5">
        <location>
            <begin position="28"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="143"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00068021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT49838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="232" mass="25487" checksum="33E8C693E9A02B09" modified="2016-11-02" version="1">MEPNIADIHVPSGPTSIHQAESFEGLTLRQLIARKDNLEAELKALGAVLDSHGVTMQTSLTTFDGFPRSDIDVAQVRVTRARIISLRNDWKALMDKIEKGLHEHHAKYQASDEYKNSLNQPQPQPQPTPASQQIPSVPETPFAQVNSVEPGSPANEAGLKAGDQIRRFGTAIWSNHERLRKVGEVVSQNLGRPIVVKVARGTGPQAQELELRLTPRQNWGGRGTLGCHIVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMX2</accession>
    <name>A0A1C1CMX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMX2"/>
    <dbReference type="STRING" id="86049.A0A1C1CMX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07125"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08769"/>
    <dbReference type="eggNOG" id="ENOG502RXAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4851849at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="469" mass="54166" checksum="5577A327860E2FA6" modified="2016-11-02" version="1">MDPRTADPVQSIWRDLPEDIFREHLVRLEERTNAVPMDVQQSDVSTNIKSHRSGHLLSVNDEQGLANAFAILVAVEEGAQSVAAVCLEEDVKLTTLTIRFAAVDAISEAVQGALRRVIDVLSMKSDHLVDSHLKLDELFRLVTKMHFRRILGRLRSSKWTKPKFLSRSHKKPLWRDFANLSHRVQFLYTKRELSIRQSLEEQLENLTRLYSSFEIVALDSAEEFAHLIRLVRTSYDFCTHEVVQEYARRLENAGPTSQVRSALKTIRQIEKIAAYYRISNTLVRISRLYPQYFQAEKLALNFLPPYASVPTSIGYEDWAKTCHVHAEIQLIVYCDMHSWDPVTSNSRSHDSHKANFLPPRVIGTSKYLCYLCYLFMKVHGRYPAANTHGRLYDQWTIPDCAEFGNEQRNFYRYIIQQMDKEVLARASEPPLWRPEPMTSRENLLDSIGDESSTVMWRRPPPDGGRNAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN67</accession>
    <name>A0A1C1CN67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_06997</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN67"/>
    <dbReference type="STRING" id="86049.A0A1C1CN67"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06997"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08855"/>
    <dbReference type="eggNOG" id="ENOG502T44Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT49940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="535" mass="60234" checksum="4402170ECEDCC201" modified="2016-11-02" version="1">MVGVPGKSQGCNTCRRRKVKCDLEKPHCRRCVSSARQCEGYERYAVFINRGQQGLQKRERLEEVRTPTTSDPSALGIQYANTPLNFSPSPRQANETQLVSSFWETYCASATRYPGPTEPAWLYRSISSATTPTAVIAATSMLLKQALLSLAHIRIGRLNDDQALIIRGQQIYGQSLRLMQHALHDPVLAHSDDILVAARCMVLYESFESTSGDMAAWENHILGIARIIHLRGVHRTRDSISRSVLESIRYNVMIVSLMRSTACFLGESEWLSVPWAGVSKSLDQRLFDYGFTLAYMMQRSEAVSMPTSLSVPSQYRHQQIHQSASKRQTILDILEQTLACYTGLANLRSELLATRRQMLRVVNPPSIQSQQLYNEDTTTDEQHMHLACTDNDPQAITIAILLALDLSFSIFATALMQHLADDHGRDLNHHPPSHSGRDLFAQLAEYMAPTRRLQLGQQLLRHLQLCCAVRSEHLRPRIIFPLNVLRWEMRHRPAEAAQVRALFEAVASRGKFRIAKGAQNAGTEIVPGIVLESER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNG2</accession>
    <name>A0A1C1CNG2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase AflX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">aflX</name>
        <name evidence="5" type="ORF">CLCR_07501</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNG2"/>
    <dbReference type="STRING" id="86049.A0A1C1CNG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07501"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08901"/>
    <dbReference type="eggNOG" id="ENOG502SM0C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF37">
        <property type="entry name" value="OXIDOREDUCTASE MDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="11"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT49992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="275" mass="30166" checksum="8027CF4256E08BFD" modified="2016-11-02" version="1">MVDSDAYAILGATGNCGTALIDNLLRRSDTVVRAYCRSRTKLLRSMPDLKEDGKVKIFEGSIQDVELVASCVYNCRAVFLVISTNDNIPGCRMAQDTATTVIDALKLLRKREMVHNDGDLKAGPMTMPKLILLSSSTIDSHFSRHMPYLLRSVLLCSASHVYRDVAEAEKLIRAEDKWLTGIYMKPGALSVDKQRGHAVSLTDQDGPVSYLDLAAAMIEAVDDEGGRYNGQNISVVNTNGSAKFPTGTPMCILMGLLRHFFPTLHDYLPGNLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNM7</accession>
    <name>A0A1C1CNM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNM7"/>
    <dbReference type="STRING" id="86049.A0A1C1CNM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07583"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09017"/>
    <dbReference type="eggNOG" id="ENOG502QWD2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF22">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="228" mass="24641" checksum="21D4C187DEA412AD" modified="2016-11-02" version="1">MSHRNICITAIDGNTGSSIAKYVLEHENFKKKVGTITGLALNQNAPLAKEVQKLGVKIVQHKPGRVKQMVELLKSTGADTICLIPPAAERKMDITRELVDATKKAGIPNVCFISSAGCDLADPQKQPRLREFIELEALVLAAKGDPSTETGHSPVVIRPGFYAENLLLYEPQMEQEKSIPLPIGDKHKFAPMGIKVSGSYNYSALVGGDGSGKLTGCGRTSRMLRLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNU3</accession>
    <name>A0A1C1CNU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase 4 core regulatory subunit R2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNU3"/>
    <dbReference type="STRING" id="86049.A0A1C1CNU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07217"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09066"/>
    <dbReference type="eggNOG" id="ENOG502SBSZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="44558" checksum="19D3BD95A8B5BB64" modified="2016-11-02" version="1">MPRPYPVVNRPAPSSPTQTQPPTLRDSNPVSQTPSTPARNLPPVPPFPNSSATTTSHVPDSLPPSQDPPIDTVNDLPALLLQILNSVTHNLRSSFSKRPPHTIQRLAELILYPTTHYKTLPAWLRAIDRVVSVSSPADIFPLSETPALVNGVNGDGGGGILWSNSDIRNGYDSASLGSDESLGGALLTPIPWLRNGGAGSEDSSEDSGLLDSNASASTDGLEDPLAMPVTRMNGDTLVPERPDGAVTQGELIRLEQEAGVVPVTRNPPDTHVSGTSEENSLPEDADMVPHARGPDLVGSVDMGRVDGQDVELRIGSPPGEDGKRETDANDAQTVLPGNVPTVGPAGDSKASSSGAASTADSEDFEIVLKDAVGDGDSEAMQLDNTDTKAQDIQRQQPSDDQDVDIVLVDADGKTEDENSGENKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP18</accession>
    <name>A0A1C1CP18_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein phosphatase 1 regulatory subunit SDS22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sds22</name>
        <name evidence="5" type="ORF">CLCR_07246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP18"/>
    <dbReference type="STRING" id="86049.A0A1C1CP18"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07246"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05746"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072357">
        <property type="term" value="C:PTW/PP1 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000446">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit SDS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="4">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT50244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="390" mass="44086" checksum="CB1EF70EE838DC83" modified="2016-11-02" version="1">MTDRGQDQTSAPPSQVNGDDEDKHAQIELPPADATKQNPSTAAPLTNSSGWDGKLRMPPRNAVLTNPEILSDPEYSDPDAPPVDEIEADEDLLDDYPVDTEDIDLVHCRISSLPALRLERFTNVQRLCLRQNAIASIDLPANVRVTLQELDFYDNLISHIKGLEDMPALKNLDLSFNKIKHIKNVNHLTTLTELYFVQNRISKIENLEGLSNLTMIELAANRIREIENLDTLKGLRELWLGKNKITEIKNLSPLTNLRLLDLKSNRLTTLSGLSDLTNLEELYVSHNAIPAIPTDALIHNNKLRVVDISNNQISHLENISHLTELEELWASSNKLSDFREVERELGDKENLETVYFEMNPLQFQGPAVYRNKVRLALPQVKQIDATYVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPS5</accession>
    <name>A0A1C1CPS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MACPF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07308"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05533"/>
    <dbReference type="OrthoDB" id="4457531at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39196" checksum="6E1E0367CA2457D1" modified="2016-11-02" version="1">MDSSDDSDIRLLSIRKHAAAKAPFNVPAPDLRAVQLPSKPFGPKAFETKVLEIGLFSGFDSKLATAPDLGPFRADSPFQLEDSYEVVVTPLGRNSFSDVTSTSSSSSYEHLSASVGIGVDCVVFGGSVSVSYDKYVTTNTDGLKHSQHAICYDSAIRYLKAPPLSEVAKHVLREQGEAAFQARFGDYFLGGFVTGAETGLLMSYAHLDREETEITRFTITVKVLFWSASHTEETVHTDTLETSSLTFTSFNTLDPASSRINTAPGPGSIGITSRNPTIQETQEQVKNITLTTQALSSLVAAKRQSIFGTALSPEDWDAGGTFNVAHAATRLTRMYPSGALLQIQLIPYTVLWEYQEVLGSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPX3</accession>
    <name>A0A1C1CPX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenol 2-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_06770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPX3"/>
    <dbReference type="STRING" id="86049.A0A1C1CPX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06770"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05472"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006144">
        <property type="entry name" value="PRK08294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF10">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="424"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT50538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="628" mass="70224" checksum="C3A215F472767C95" modified="2016-11-02" version="1">MSTMDPETIDVLIVGSGSAGLTAALWLSIYNHSHPATRTKPIRYRVLERRDAPMSIGQADGIQCRTVEIFESLDLSEDLLREAYHVLEVAFWSPSPNPASQADGSGRRGIVRSNRAADTAKGLSHMPHLILNQARVNGLLLEKMQKLGGRQIDYGWTVKRVVVDEEMAARDPEGYACTVVATKDGGDEKVFKAKYVLGCDGAHSVVRKSLGYNMIGDSTDAVWGVMDIYPQTNFPDIRRKVTVHSDAGSLLVIPREGGSLTRFYIEFPTGTNVKEVKLEHLHQKAQQIFYPYEMNFADTFWWSCYSIGQRLADNFTKANRVFLTGDAFHTHSPKAGQGMNVSLQDGFNIGWKLGHVLTGQAGPELLKTYNVERGKTAADLIDFDRYFMKLFASNKAGSEKKITPEEFREGFIKSGRYTAGLTSKYEDSSVTFSAASTQELAKEIVVGMRLPSAQVVRFCDVKAMQLVRALKADSRWRTIFFVGRIGEPETLMRLEKIAKYMDSPDGPAHKYTAPSADIDSFIEPIVVFTGERMKLEQEQIPDYFWPITGKWRMRDLHKVFVDDEHYNSGHGHAYEKLGIDPDKGATVIVRPDQYVSKVLPIDNMQGVGQFFDAFCLPKQGNGVQDSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQA9</accession>
    <name>A0A1C1CQA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_07504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQA9"/>
    <dbReference type="STRING" id="86049.A0A1C1CQA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07504"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05350"/>
    <dbReference type="eggNOG" id="KOG1722">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="157" mass="17674" checksum="98DC8A57FCBEA599" modified="2016-11-02" version="1">MRTYDDTFSGTKIYPGKGKLYVRGDSKIFRFQNGKTESLFLQRKNPRRIAWTVLYRRMHKKGISEEVAKKRTRRTVKHQRAIVGASLDVIKERRSQRPEARAAARQAAIKDAKEKKAASESKKKAEKAKSAANASRGQITSKQGAKGAPSKVKATTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRF6</accession>
    <name>A0A1C1CRF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Folic acid synthesis protein FOL1</fullName>
            <ecNumber evidence="10">2.5.1.15</ecNumber>
            <ecNumber evidence="12">2.7.6.3</ecNumber>
            <ecNumber evidence="11">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Folic acid synthesis protein fol1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">folP</name>
        <name evidence="22" type="ORF">CLCR_08924</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the central section; belongs to the HPPK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="10"/>
    <dbReference type="EC" id="2.7.6.3" evidence="12"/>
    <dbReference type="EC" id="4.1.2.25" evidence="11"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRF6"/>
    <dbReference type="STRING" id="86049.A0A1C1CRF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08924"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09695"/>
    <dbReference type="eggNOG" id="KOG2544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000006">
        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="21">
        <location>
            <begin position="23"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OCT51061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="298" mass="32513" checksum="31900F384454CC7C" modified="2016-11-02" version="1">MSPVTVLHRDLPLIRVRDATRKTLVMAILNLTPDSFSDGGIHSDLQTIRASVAKFITAGATIIDIGGQSTRPRADLLGPDEEMARILPVVRAIRDMPEAEKVAISIDTFHSDVARETILAGADIINDVSAGLLDERMLSTVAELGKTVVLMHMRGDPHTMTRLTDYPDGVVRGVARELSTRLQAALDAGIPPWRIILDPGLGFAKNQEQNLELLRSLRQLRESTDNSSVLQNYPWLMGPSRKGFVGNITEVAEASQRSYGTAAAVTASIEGGADIVRIHDVNEMMQVTKMADAIYRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRL8</accession>
    <name>A0A1C1CRL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit tim16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pam16</name>
        <name evidence="15" type="ORF">CLCR_08999</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRL8"/>
    <dbReference type="STRING" id="86049.A0A1C1CRL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08999"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06950"/>
    <dbReference type="eggNOG" id="KOG3442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT51118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="204" mass="22519" checksum="9481B90D88753070" modified="2016-11-02" version="1">MDMSRHCQWETHVRTAGGGQSHARRHADPTVPSVTNACKSSAQPRFHIALRVDNSPSTTLLPPAALIVLLWPTVINGGRVFGRAFAEAYKQAQASSQFARAAAKNDPGAVNTAAASGMTLDEACKILNVKPPQGGITNMESVMERFKKLYDLNEPKKGGGGSFYLQSKILRARERIEMEVRNAERKAQMEKEIKEGWRPKLYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRR3</accession>
    <name>A0A1C1CRR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S16-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPS16B</name>
        <name evidence="5" type="ORF">CLCR_09117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRR3"/>
    <dbReference type="STRING" id="86049.A0A1C1CRR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09117"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06883"/>
    <dbReference type="eggNOG" id="KOG1753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="143" mass="16175" checksum="7380F45ACCDED997" modified="2016-11-02" version="1">MSAPQSVQCFGKKKTATAVAHCKKGKGLVKVNGRPLNLVQPEILRFKVYEPLLILGPERFSEVDIRVRVTGGGHTSQIYAIRQAIAKSIVAYYQKYVDEYTKNQLKQALVQYDRTLLVADNRRCEPKKFGGPGARARYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRV7</accession>
    <name>A0A1C1CRV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09305"/>
    <dbReference type="OrthoDB" id="5410802at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="93" mass="10091" checksum="55ED3C7473ABA5BC" modified="2016-11-02" version="1">MPGQTLSRSSSTSTRSEGTIDLEPETSALPSWVNKVLLAAEEDQRNQPWKATFGESIGLRFDSEEDLVRIDRSFGGLDDPSCPFNTQGSSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS54</accession>
    <name>A0A1C1CS54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">HNM1</name>
        <name evidence="7" type="ORF">CLCR_08137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS54"/>
    <dbReference type="STRING" id="86049.A0A1C1CS54"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08137"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06765"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="491" mass="53731" checksum="7E32E49301EC0EA5" modified="2016-11-02" version="1">MAVTPATVASSADDREDVHIDIDDLELKAQGYDRAMPRRFNLLSLISMSYALLATWNGFGSAFGTGFTEASSAGSIWTLTIAALMTAVTGIGMAELASAYPVAGAQYYWSYVVATPEWGPFASYISAGISTLGWWLGLASVTNFIASMITGIAVLNHPDYVIERWHIWLIFVAITWSAIAMNVFGTRWLPLWNKFILFFSATTLIVTMITILACAAPKFQSAKFVFSDTTNSTGWPNDGLAFLLCLVNALYGFLGVDCGSHLCEEIPRPTVNVPKVIMYPVLMGFVTCFPYAISLSFVITDFEKVIATPTGLPLIEVYYQATGSKAGTSILMVAFAICFFGCATASVTSASRQMWSASRDNCFPFAKYWRQIHPRWQMPVNAACLEGTLVSGILAWRGRDKVLPPRALNLGKFGLPLNVLACVWVVFIDIIYCIPVFRPVTVGPNLNLELLQAARHDELLGHRTIDGVPVGDDNGVLEALRQRSISQDKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSG0</accession>
    <name>A0A1C1CSG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromatin remodeling complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSG0"/>
    <dbReference type="STRING" id="86049.A0A1C1CSG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08053"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06639"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74201at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="666"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="760" mass="81684" checksum="15007C5FE715D8A4" modified="2016-11-02" version="1">MPPFKDEHVLIIAPGSQMTAAQLGLPESFTPPRYRFPTRMFPGTNPGEWEPVKIRTKITTKPKVVEAIPTIEPVEGGSAEIDSKPDVTTDGEAQNVESIADQAKGEQPKVEQANAEEPPKGEQPNGEQPGPEQQDADQASGEKSNGAPVVGEDVEMNEAPPVEERPRPETQDTEMEPTAVEQPQTQPEPAQEDPSAMTIVEDETTETFEDDHWSTEGAVYPIVAGHIENWSCFFALLSHIYNMISPPFHMPVLFVAQPCWSARDHEMITQYVFENWKIPAFCLMDSALTACYAYGVPTALVVDVGHEKCDVSAVTEFQVNDIGRGTALAECGGRSMTRRLLEALEKQGFDEDMAEQLKKSPICEILPPGTPYPQATPNGKPPPTVNPAAAASTGALDSGAGAKDGEGLRPGQAPRGPGVGTTVGEEGANGEDEDNEGVLDVAAIVARDNAAEVLAKREREKAEKAAAKKGSAAEGPRPIRLRNSERERATFTYVDYIPLDEESATEQPLSRKRKREVEVGVERFMATNPPPGTCDGIIDVIAEAIHHAVLSVPDVPQRANLWDNLIVLGNGSRLLNDTLGFTPALLAALNSRYILSPSTATIFTSELPSNFTTPVATPGTNTPIPGQGNHPLYHPAGHGVNPLLVAATKNMMQPNPQHLTVPNTATGIGTPASLDPNHPLSSHHHRGHSQSPTSIKTVKPPEYFPEWKNPAVAGMEEASFLGAQVAAKVVFIVDQGNSKGFLSRSEYNELGPSGIHECAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSG7</accession>
    <name>A0A1C1CSG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative ca2+ h+-exchanging protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_08225</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSG7"/>
    <dbReference type="STRING" id="86049.A0A1C1CSG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08225"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06646"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF18">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="82"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="384"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT51436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="535" mass="58112" checksum="4F1362ECC914EF8B" modified="2016-11-02" version="1">MCHPLHVLGHRLTRRRAGVHRHERSSPEESSPISTAERKWYSRYLAEAFVTIRDILFYSKLNVLLVVVPLAITSYLVHTNRVLVFAANLIAVVPLSSLLTCATENIARESGDVVGALANVTFGNLVEIVILIALYHNRLEVVQASLIGSILVNLLLILGIAILAGSFHHHQLAQNKEDAQTLACLLSFSVLSLLIPIRKIPRNQPSIDVMSFDELSATAAPSQEARSSSALLLPRSIRFQDEEAGQSRTAKGRGRGDSLEMSALGGSGESQDESEELHDRFDLESSINGEELEPSPLSDKGGNSRSSIYQHPSSRQRSESLQPNNRYTSPAGQQRSRHHLSFSGSSTSLPRLLVGSSRPSAENLCDVYAPQESPPKIGRVASSLLLVISSLLVALCAEFMVDTLDDMVESGPFPQAFIGLIILPIAGNCAELFTATYVAAHGNFDLAIGVSVGSSVQISLLVTPLIVIAGWILRKDMTMYFDLFGTVALFATTFLVNVLIVYGKSNFLEGSLLFACYFIIAVGAYLFPAPENRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSK9</accession>
    <name>A0A1C1CSK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative 2-oxoglutarate/malate carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ucpC</name>
        <name evidence="11" type="ORF">CLCR_08800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSK9"/>
    <dbReference type="STRING" id="86049.A0A1C1CSK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08800"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06606"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="102"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT51478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="219" mass="24283" checksum="61330B3F4C4853D0" modified="2016-11-02" version="1">MPKSKKQGQPFWLGGAAASMAACFTHPLDQTKYRMQVMATRQNMLRTMMQFASRDGILSLWWGISASMLRQSTYSTARFGLYNHFANKARERSGATRLTSGWEVVCAGAAGGLAGLIGNPTEVALVRMCADGAKSPAQRFGYKHAFDAILRIGREEGIQTFTRGLGPNVVRSVIMNIPQRSAGFFQTRRSASKTAYLHTFSLPWLQARSRQLLAHQRMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT37</accession>
    <name>A0A1C1CT37_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT37"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08572"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06426"/>
    <dbReference type="eggNOG" id="ENOG502SERI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5420013at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="435" mass="49390" checksum="997044912DFAA5F6" modified="2016-11-02" version="1">MEDNVSLRDHTARLDIEQVGDPGIPARDSTIENDPAATVRPTAEIPDEPERSGFELSPQISKSSKSIRLESPPVVIRPPKVKPVGFSYAALSWLSWNRNEEKDVPDCARSMHRSYSYRTTFRFLGFSLSKDIKYRTSAGGIDTAMATIRLGWGSSEANWVLDKLPKIRQRLGLVSKEQRYPTDAERQSVSSREQSSTTAVENQKAPNEPGRAVRSIAHPWLDDYYYVVVGIMGDQTAPKESLRRVMRIDGLFQQIRKAHRQLRNPVRRGMSLKEVSGFGIYQCDPSKGHHREAELDPETERALADLWRSYNTQKLDYEGRWLMWIHQHFNNGSKNAELGTLTLELKLRWSVFKVVFWGVVPILLSMAIGFWYMYSDHGEVDDVAVAEAAWVIATYIITTSACEYPHRQLDRAKSINPEHSVIFALLAVITQLGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTJ1</accession>
    <name>A0A1C1CTJ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_08038</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTJ1"/>
    <dbReference type="STRING" id="86049.A0A1C1CTJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08038"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00084"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06326"/>
    <dbReference type="eggNOG" id="ENOG502S0TA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2579025at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="680"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT51789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="780" mass="85580" checksum="A7E6A679C8F6808D" modified="2016-11-02" version="1">MDTTPSVGHDGDLPSSPPKRRKLKHPRTARACLFCRRRKVRCSGTQPCDYCNGEGVRCEYDGVAKPPARDLDRVPLSTTHHVQAAQSPSVRQPGFFLGVNSRETHPTQPASTRDATNSKGQGPDPLATVPNAHTPRISRGPSLEPTFAEGHHIGATAGVSFLYHTLNRGEVAEAETNLPTAPLTCHGDIPPMKVRQDQPMPSREEADALLERYSRFATPTYRFLHRPTLEKWTSGLLTGARLSTAEAACTLLVFSQALLYMKDNDRYVDGGDQDLHRSQFYFEKAKSLLNQEPGPASLASVQSRLALCLYLLSTFRINECRYVFSLACTILTSLGLHRKSSAASSEVDLVALESRKRTFWCAYVLDDYLSVMLGRPRMLRDEDIDQPYPRNIDDQDLLSSESPDELPLHGNLEAFIAHADLAKLMGRNSDLLYPLHPLTDDQLFDRTNEMLESVTQWRDRLPDFLKPRDKTLAGQRTFERQNTVLKLAYAHLRILVTRRCLLADFSRLGHSTPSPAPSSLDDRALEPVQECVAAITTILNATHDLVQRNALYQAFWFTQYIALVAISTLYVYVIQSSRARLPAGIFPGLDAIFDKALLCQDYLAKLAPEGSQARRHCHLLSRLRLRAEKDAARARKMGTGAGAGVGAGAVVAATVAADSGSESSLPARANVPSAFEAATTRGPVVESAGHEREIDSQRDTGASDHQDGGTAGGTGGVGENFRGLEASNLDLDIPADKGMITAQFTPSEDDFMFQNLLGWGWETLDTVGFPGDGDVFKLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTW2</accession>
    <name>A0A1C1CTW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="10">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="9">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="primary">prnC</name>
        <name evidence="12" type="ORF">CLCR_08346</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="9"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTW2"/>
    <dbReference type="STRING" id="86049.A0A1C1CTW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08346"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06194"/>
    <dbReference type="eggNOG" id="KOG2455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="60"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT51935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="550" mass="59739" checksum="A8D83C171E0B0058" modified="2016-11-02" version="1">MSTLAAFRLPNITNEPNQHYEKGGRSREGLEAAVRALQEKAPLDIPIVVSGKPVKTSSVLTQSNPSSHATPIAKYSNASATDVKKAIDAALAAKPAWESLPFADRAAIFLKAADLISTKYRYEIMAATMLGQGKNAWQAEIDAAAELIDFLRFNVRYAEELYAQQPPYNFPGVWNRVEYRPLEGFVYAISPFNFTAIGGNLPGAPALMGNVVIWKPSPSAIASNYLVHQILTEAGLPAGVIQFVPGDAEEVTQAVLSHKHFAALHYTGSTAVFRKLYGQIGQGIAEGRYRGYPRIVGETGGKNFHLVHKSADITNAVVQTVRGAFEYQGQKCSATSRLYVPSSIWPEFKSKLVEATEKLKVGPPEEFDNFIGPVIHEASFKKLSGVIDAAKDDSALELVTGGKYDSSKGWYIHPTVYVAKDPSHRNFTTEFFGPILTVYVYDDSAPDSFEKACELVDSTSEYGLTGAVFAQDRAAVRYAEEALRNAAGNYYINCKSTGAVVGQQPFGGARASGTNDKAGSAAILSRFVSMRSMKEETLPTTKVEYPSNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTX4</accession>
    <name>A0A1C1CTX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vma5</name>
        <name evidence="7" type="ORF">CLCR_08491</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTX4"/>
    <dbReference type="STRING" id="86049.A0A1C1CTX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08491"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06184"/>
    <dbReference type="eggNOG" id="KOG2909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="405" mass="45674" checksum="62C23E5C003E3C26" modified="2016-11-02" version="1">MSSTKYLFVSVPSSITPSGHKDDALAALQKAANPSNGSVLPLAVPEFKIGTLDALLQQSDELAKLGGLCASVVSKVGDTLKNVLDGDEEKIAMHKTVNDKREDEDEDEEHRMLTLGYLRSFSWNKVKYRADRPLAELIDLLQKEANSIDNDVRSKYNQYNSLRTQLQTLTRRQQGNLSTKSLLSVVQPSILVQNQQSEHLETHLVAVPNGNVKEFMRSYETLAPMVVPRSAQFVAQDDEYSLYAVTTFKKHSAEFLHKVRERKWVPRDYKFKEGGKEEEERELKKTEAEEKRVWGEALRLGRTGWSEAVMCLVHVVVLRVFVETVLRYGLPLDFVAVLIKTDGKREKNVRKGLDNEYSYLAGNAFGRDKKGRVMKDEGMGQQDMVAGGGDQGEYSAYVCYDIEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU51</accession>
    <name>A0A1C1CU51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">sec26</name>
        <name evidence="15" type="ORF">CLCR_08009</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU51"/>
    <dbReference type="STRING" id="86049.A0A1C1CU51"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08009"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06105"/>
    <dbReference type="eggNOG" id="KOG1058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="13">
        <location>
            <begin position="583"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="14">
        <location>
            <begin position="724"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="14">
        <location>
            <begin position="819"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT52028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="877" mass="97386" checksum="1424D96C5208D448" modified="2016-11-02" version="1">MVPSNGIRNDLQHPNEFVRGNTLRFLSKLREPELIEPLLSAAQTCLDHRHAYVRKNAVWALASVYQHAQHLIPDAPEMLHTFLVGESDTTCKRNAFAALMSISHEKALEYLIGVLDGVPNADELLQLVELEFIRKDAIQNQANKARYLRLIFDLLEANTSTVVYEAATSLTTLTSNPVAVKAAAGKLIELSIKEADNNVKLIVLDRVDQLRRRNEGVLDDLTMEILRVLSSPDLDVRRKALSIAMEMVSSKNVQEVIMLLKKELSKTVVEQYEKNSEYRQLLIQSIHHCAIKFSEIAASVVDVLMDFIADFNNSSAVDVISFVKEVVERFPKLRSSIIERLVSTLGEVRAGKVYRGSLWVIGEYSLQENDIKEAWKRIRASLGEIPILASEQRLLDEQSNDDGEQKDQVNGHAAAKAASTGSRKVLADGTYATETALTSDSAAKARLEAVKAAQKPPLRQLILDGDYYLSTVLSATLTKLVMRHSEISSDQARTNALRAEAMLIMISIVRVGQSQFVKAPIDEDSVDRIMSCVRALAEFSERKELEVSFLDDTRKAFRAMVEVEEKKRADKDAVEKAKTATQVDDVLSIRQLSKKSAQDGMDEMEIDLEKATGGDASFEDLSSKLSRVVQLTGFSDPVYAEAYVKVHQFDIILDVLLVNQTQETLQNLSVEFATLGDLKVVERPTTHNLGPHDFLNVQSTIKVSSTDTGVIFGNIVYDSPSGTDTHVVILNDIHADIMDYIQPATCSESAFRTMWTEFEWENKVNINSKATSKSLREFLDQLMKSTNMTCLTPEAGLKGDCQFLSTNLYARSVFGEFQHCLTAKIATNVEIGEDALANLSIEKTADNSIVGFIRIRSRSQGLALSLGSLKGLKAGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU75</accession>
    <name>A0A1C1CU75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase 2</fullName>
            <shortName evidence="9">MAP 2</shortName>
            <shortName evidence="9">MetAP 2</shortName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_08587</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU75"/>
    <dbReference type="STRING" id="86049.A0A1C1CU75"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08587"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06088"/>
    <dbReference type="eggNOG" id="KOG2775">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="12">
        <location>
            <begin position="132"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT52043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="448" mass="48947" checksum="56E6717737B95696" modified="2016-11-02" version="1">MAAKTADELSKLALNGTATKQNPHINGTNGVNGHLSDQGDSDDDKDDDAPVNGGAADGAASGAAKKKKKKKPKKKKTAKVQSDPPRVPLKDLFPGGTYPVGEEVDYKDHNAYRTTSEEKRHLDRTRNDFLQEYRQGAEVHRQVRKWAQANIKPGMTLTEIAEGIEDGTRALTGHWGLEEGDNIKGGVGFPTGLSINHIAAHYTPNAGNKWILAEQDVMKVDFGVHINGRIVDSAFTVAFDPKYDNLLAAVKDATNTGIREAGIDVRVGDIGAAIQEAMESYEVELDGKTYPVKSIKNLNGHDIIQHSIHGGKSVPIVKSNDQTKMEEGEIFAIETFGSTGRGYVTDDLEVSHYALRPDAPNVPLRVQSARNLLNVIKKNFGTLPFARRYLDRLGQEKYLLGLNNLVSSGIVEAYPPLVDIKGSYTAQFEHTILLRPTVKEVISRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUH4</accession>
    <name>A0A1C1CUH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUH4"/>
    <dbReference type="STRING" id="86049.A0A1C1CUH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08718"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06000"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="386" mass="43414" checksum="1CBFAC8DCC0255A1" modified="2016-11-02" version="1">MPRHLAPHKSGPHRLACLGLFRSLLRESGHVGTATSSTGIAEHLRSLVRYRFHKDRTLLSRSQIIRGLEAGHGFLGLLRGCAAKSPTALDQLSKLLEQVAVQAESTATYRRTLAARWKPPPPSRYAHLENLRRVADKANHASTPASPRIFQHPRPLSEVKTGVRKVPNLILAQGIPLLKYPGPTPVLVNRVLKEKIRWGVRKWEQHKDIQRRIQIAEWEDQWDSILARIGNIVDHDDADDDDGGAGAGADLLAERDGVQRSAKSHNPRGTTRYYHRPVEGAGTSPKQHPSSGFKPRISWATHLREVDRGLELAVLERGKQYAVLGERYWHEVVVKERELREQERKERKHARRMARKQASGIFGTEGHVPTQHDQDLQPSSVSSGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUJ6</accession>
    <name>A0A1C1CUJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Granaticin polyketide synthase putative ketoacyl reductase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUJ6"/>
    <dbReference type="STRING" id="86049.A0A1C1CUJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08866"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05987"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF2">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="226" mass="24398" checksum="7459FFA3D6C535F0" modified="2016-11-02" version="1">MPYSLKGRNVGLGALLCEKFAAEGSNVVVNYMSSKDRAEEVANKCKELGAKTAVIQADVGVVEDTIRLVKESVEQLGGLDIIINNAGWTRFTTFGDLNDLTHDEWNKCWSTNVMSHLVLMQQAVPIFNANPDGGAFIISSSIAGVSQGGSSMGYSVTKAAGLHLMKCLATTQGPKIRVNAVLPGLLLTEWGLRYSEERINTIKNNAILKHEVCLPPDEDASRGLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV14</accession>
    <name>A0A1C1CV14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="5 20">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ku80</name>
        <name evidence="22" type="ORF">CLCR_08122</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of Ku70 and Ku80.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the ku80 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5 20"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV14"/>
    <dbReference type="STRING" id="86049.A0A1C1CV14"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08122"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05837"/>
    <dbReference type="eggNOG" id="KOG2326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000073">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016570">
        <property type="entry name" value="Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15 20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16 20" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 20 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="10 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Ku" evidence="21">
        <location>
            <begin position="300"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR016570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OCT52332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="722" mass="81554" checksum="3C9E142BC9654C31" modified="2016-11-02" version="1">MADKEATVYIIDVAQSMGKKHNGREQSDLEWCLQWVYDRVTGVVFTGRKTLQIGVLGLGTDETDNSMMDQDDSYKHISVLQPIAQLLLPDLQNLPKVLKPSHTDERDIVSAIILGVDMISRHCKHLKYKKRIFVVTNATGSHIDEDDLDQVAQQFKDNNIDLTLLGVDFDDPEYGFKEEDKPTDKAKNERILKRLVDLSGGQFGTMQEAIDDLSRPAIKSVRPTPTYKGQLRLGDPTQYDTALFIEVERYMKVSVRRAPTASAYISRPGGVAEDEEGDGLTSVHNLYKYRVHGDEYEGGTKVLERDELAKGYEYGRTAVSIAESEQNITKYETEAAYDILGFVPADNIERYMLMDNANIVVAQKGNDRAAMALSSLIHSLFELGSVAIGRLVKKDAADPVLTVLSPLVEGDFEGLVENVLPFAEDIRSYRFPPLDKVLTVSGKALTEHRNLPSKELLESMSDFVDNMMLVDDESGEEMMAIDDTFSPLLHTIEDAIKDRAINANDPKKSKELPKRKEVYELMQRPPAAVVERANSALQKLKDAADVKKVDKRKKGRVRARDREADKPFSGLDVEKLLRKERPIEQGKTHINPNNAIPEFKDVFNTTADMAIIREAVKQMQQIIEDLVRKDYGQKNYDMVLEGLATMRNETIGMEVPNYYNDVLREFKEKLFQGQLGENRGELWYKIRTGNIGFISKDEEELSDMTRGEADDLMKVKSSRPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV95</accession>
    <name>A0A1C1CV95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV95"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11003"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03830"/>
    <dbReference type="eggNOG" id="ENOG502RNT2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3439627at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="108" mass="11385" checksum="367BFC4126913FFC" modified="2016-11-02" version="1">MPRGAEFDNGKPQSDNAVDAGQDKIHGGGKTTDEVEISHAKKTAPLPDLSEVNDRTLSFGAAPGHQDGHGHEAPRTQGERTGMGSNKDLGKAGPHPLDNPQDESAIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVD5</accession>
    <name>A0A1C1CVD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10933"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03880"/>
    <dbReference type="OrthoDB" id="4154357at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036696">
        <property type="entry name" value="YdfO-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160419">
        <property type="entry name" value="YdfO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="161" mass="17343" checksum="23BB475EB9AB220A" modified="2016-11-02" version="1">MPNLTPVAKIFAQVHSPRGLRFPETVASLLALGVTRYHVDYTSSLITTYSASNATSQSKPVKTEQITFAGPTYNLDIDADADANANVAWDPTGVKTAIKRIQTGESSTYTDFSREIIAAGVVGYFAFLDGKRVVYYGPEGDVHVEWFPGAGPGPIVDKAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVS3</accession>
    <name>A0A1C1CVS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_09590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVS3"/>
    <dbReference type="STRING" id="86049.A0A1C1CVS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09590"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03978"/>
    <dbReference type="eggNOG" id="ENOG502SIWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="519"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="816" mass="89983" checksum="558CCDE860F3CDB1" modified="2016-11-02" version="1">MDLQQRDSTADSPGGDYADDLKMDTIADGRIEMAQEEIDAIIRNKRKVRDPKACYACHRRKVKCDRNLPCDSCVKRDHPELCSYERPTKKRRIALSGALNQPDGAGSESPNQQTGPNITVPREQWERLNRELQLLRDSAKAERLSPGAAHSEEDVNPTGTHSRGDEAEREGIHAPSTQMGTMHLGSRSVLAYMMGLGRTKTAQDTAKSLLEENILPKLGLDNESATYPFVDLWSTESSMQDVDGLCKAIPDDELCNEFFVAYRDIACTIYPVVPDVSGFEDTLHFMLSNRSRHIRDNLELDPNKPYGVSLPWLALVFAVFASGSQSSDRPAKERELTSQVYSNVLSYNMNPGVAYIYLGMTLRMAFSIGLQINSQQFTDAEKWTRRRIWWALAWQDSHFAVSYDRPTSSVLCIPDIPYGKFSSPGDRSYAETMFAIIRLTQEIVRERLLHPRSYMSWDRIQKYTEEITFHVSQGASYLRNRDLCYKMTQHLERLALKLHSCYITSELCRPALKEAPSSSSVENLTPVQSPPGSSRRKTSGTTGQSPSTSNPDPSTLSHFRTMCIQNLEGAVEAYVELHSLSKFASRSWIGIQRSISAAFLLGTLPETSRDPRRLALLRELEQVIAQRTHEDPTFDLPPDASPQAKRRFSNEAMEGQGPPLAESPHWARSMSKSLNALGKLNAALAGPRPTALSTYNAGTYPPPSANLFMAAGSASGLPTSSSPTTQSRYPPLGAGGVPSVNAIKQETYSPSLATSSTNGLLGGMSSGPGSLGPITPDSTGSSSGDWNFGNIADRAAEYVQAPLWGEGGVGTMWDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVT7</accession>
    <name>A0A1C1CVT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Structure-specific endonuclease subunit slx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">slx1</name>
        <name evidence="11" type="ORF">CLCR_10186</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVT7"/>
    <dbReference type="STRING" id="86049.A0A1C1CVT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10186"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04053"/>
    <dbReference type="eggNOG" id="KOG3005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1440.10:FF:000006">
        <property type="entry name" value="Structure-specific endonuclease subunit SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="10">
        <location>
            <begin position="55"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="411"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT52667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="466" mass="51521" checksum="2AF8DAA1E98724EB" modified="2016-11-02" version="1">MSRPTPTVEPITNRPPQCQHSSNKPSAIQPKHIISTIHQPSPPSQHQMELKPIPAFYCCYLLRSTVRHASTYIGSTPDPARRLGQHNGKVKGGAVRTSRISLRPWEMGCIVAGFPSNIAALQFEWAWTNAHLTRHISAEQRISFATTRTKTSKSGKITHRPGRPRSSLIDRLSNLHLLLRVPYFSKWPLEVRFFSEDMYRCWTTWCARVDRHIRPGIKVILDPAQPGEQEEDEFSSAQPQASQRRKRKAELIGRGGPDGVDPTYARLRGVFEKSQFLLDDGDDQKCSLCAASIDLDRSLFVICHMEHCQSISHVTCLADASLHRNQSASSIVPDTAVCPACTKETAWVELMQQVTLRNRGLKEVKELLGRKGKKSTAAVAAEIMETCSEASDSEGEEETLTAEHVVDKGLQLGSDEDDGLSVASADSFVSGPSDREAGHKPGSVVAAGGRSKPSLEMVIEDSEEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVY1</accession>
    <name>A0A1C1CVY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVY1"/>
    <dbReference type="STRING" id="86049.A0A1C1CVY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10649"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04073"/>
    <dbReference type="eggNOG" id="ENOG502S9N5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31120" checksum="40CFBAE7280B9CCA" modified="2016-11-02" version="1">MADEPGGSTVHSSATHFDQLSNVYDELVGLLTGDVGRYALDHLIPTPTSETVIHDNACGTGLVTAHLQQVASQTGTSARKIHATDHVPSVTQVMQQKASRHGWTNVEISVMDSQELSFPDGLFDLSITNFGIFFLPDPQKGADQIYRTLKAGGVAVVTTWKERRIMDTIVEAQKIIRPDLDTLHAPWAELWSREETLRNVLVNAGFPAESLKVVERRTDAIVEPFLRDPDMVARAYPAATKGWTEEERARLGKEMLRIAQERDPQGRGAGGLYSTAYIAVATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXC6</accession>
    <name>A0A1C1CXC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">pH-response transcription factor pacC/RIM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pacC</name>
        <name evidence="15" type="ORF">CLCR_09830</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid-expressed genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXC6"/>
    <dbReference type="STRING" id="86049.A0A1C1CXC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09830"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00085"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000458">
        <property type="entry name" value="pH-response transcription factor pacC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001875">
        <property type="entry name" value="pH-response transcription factor pacC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="380"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="458"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="550"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT53111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="604" mass="65427" checksum="FE2AB61D2EEE2AA8" modified="2016-11-02" version="1">MSENNSTTPNTAATQDATQQQGQLQAPLASNPAPNVNAAGENLQCQWQGCGERCPTAEALYEHVCERHVGRKSTNNLNLTCAWGQCRTTTVKRDHITSHIRVHVPLKPHKCEFCGKAFKRPQDLKKHVKTHADDSVIMRSPNLEPGGGQRSVQNGMGQGGHYNASYYGRSLTGQVPQNYYAPAMPGPHDYAAQQHPNQYYQPHPQVPTGGHPGYGPVTYYSTAPPTASYDFEARKRGFDALDHFFGQVRRREVDPINFHNVSRRLFELQGLQLPQIIPAAVPTPAYQPVTVGGAYGQEDPIQAYSLPPMGNAKTREDLTSIDQILEQMQATIYEQDAHLTAGVAPAGAGYVTYARASNSPPSTSHHGPAAAHANATSLLQHGHQESIASNTDASTPGLTPPSSAQSYTSGQSPLPGHAAPTSSAMYPTLPASASDMAYAAANAATLSGLYDEDRRRWEGGRLQRAAPGKGRDDMDMASDGSVTPPASGLSKESKGKKRDSPVSSVIDPALDTADTPRESKDSPPDQTEMWVQNMRLIEWMREFIKKKLESGDYDGATPEPVKDVAKTDVGEQDDTEMGGTDDHKEKTTDAEQLYPVLRHVEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXR8</accession>
    <name>A0A1C1CXR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Zds1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXR8"/>
    <dbReference type="STRING" id="86049.A0A1C1CXR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09550"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00165"/>
    <dbReference type="eggNOG" id="ENOG502RC08">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="742"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="824"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="910" mass="100236" checksum="FF6A033892DB8681" modified="2016-11-02" version="1">MQTSTRSRDTGASFAARQRGHLPQLSISDENHHVTETIGYLYDDDSDHDSRPSAHYSNSHHHASAQSPGKVNGNHTPQDLAPGRTPSMPRKQLHFRDMSGDNAAQQAIGVSRASPSQGHSWDHQNHNHTPSSPTAGSRERSPSDTATSSFPLNDIDYESSPAGLAQELSNLQALRRMSMHVGATDDPDLPQINAAGMPSAPSPTSSEDDSSRLFWVPARLHPELAPKEFKTFLESKAEQIRRRSGELSAFTSPTSSRSSSLSTEGGSSGLRRKKSMLSRQIDSSVGYQDGADRLERKRSLSRRTNPQDPNLQELENLVSNTASLSRTSLDPSSEDDSGDIILPSVPGNSLKRSTRTTYRRGGSVKVRGDRGTYAQRAARRAAAGSPSESRPESPEVSVPAIPPLPNLSMDVPNLAQTLKDPSHAPGVVKALPTNFSRPATSSSASPSSSVPTTLDSVFGYDDAKRTSTASMPDIRKSPPPARSPPSSITSFERKPAPVPQIVETPPPPESPQIAVQPPRSSSMAPPTVQQPMRHPERVSSREDTRSRAISPQRPPMPSKGSLPSITPRATSPNTMPPPNRPSLSLEQPSPLPGNDTNTSNLSFIPTLTVDKRADHKKKEETKKSSWSWLLGKEDGDKEKPEKPKAKILKPPQTHDNTRLDVLQTSIDGGGKGRESLVLDREHLKLDEERKKESQRKTSGSDKKEKEGLFSSIFGGKKAKGDKDSSKKHRDRGLSPEPPYRELKPDIDYNWTRFSILEERAIYRMAHIKLANPRRALYSQVLLSNFMYSYLAKVQQMHPQMNLPTSAKQQRKQQQKDQPHQPDEYVQYQRYQQAQQQQQPQVEQQHAAQQDMGNDASGHEFDAGISRPSSRGSKHSVESNGSHGSSVAGYNQQHYHTNAQAQQHEDDDDMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXT6</accession>
    <name>A0A1C1CXT6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">idh2</name>
        <name evidence="16" type="ORF">CLCR_10320</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXT6"/>
    <dbReference type="STRING" id="86049.A0A1C1CXT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10320"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00321"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045242">
        <property type="term" value="C:isocitrate dehydrogenase complex (NAD+)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="57"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT53354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="386" mass="41734" checksum="66941531E6F278E7" modified="2016-11-02" version="1">MIAPRAFAAPARQCLRKACAQPIRAPIFVQPRRYATTAEADKVAKFKGKKGSDGNYTVTLIEGDGIGPEIAQSVKDIYKAAKVPIVWEPVDVTPRLKDGRTVIPDEAIASVQKNYVALKGPLATPVGKGHVSLNLTLRRTFNLFANVRPCRSIEGYKTPYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRYAFQYARDVGKNKVRVVHKATIMKMSDGLFLSTARDVAKDFPDIEFDAELLDNACLKITTDPGPYSDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKSLANPTALLLSSIMMLRHMGLNEHAAKIENAIFATLKEGKTLTGDLGGKAKTHEYAAGIISHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY09</accession>
    <name>A0A1C1CY09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cut9-interacting protein scn1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">scn1</name>
        <name evidence="2" type="ORF">CLCR_10381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY09"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10381"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00394"/>
    <dbReference type="eggNOG" id="KOG3020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="380" mass="42927" checksum="EECBFCA346AD8EAE" modified="2016-11-02" version="1">MAGNEHSVDAIWQVGVFDAHCHPTDILASIKDIANMKARVLAVMSTRLQDQHLVRQAAERYLLKGPHADFTEDSSRYVIPAFGWHPWFSHQLYNDLDEADVEPDQVQHYENVLTPRPDDVQFMQALPRPRSLCQFLQETEERLQDFPYALVGEVGLDRSFRLPAGPSAMTGDMKSKTGGSEKEYTPGTREGRPLSPYRVNIEHQKAILKAQFELAAKLRRPVSVHSVQAHGLVFEVMEALWKGHEKPSKAQRKKARVVAKTHPADEKSQASPFPPRLCMHSYSGPPDALKRFLAPSIPADIYFSFSMAINFSNTSTAKVTSVIKAVPDDRILVESDLHCAGERMDKLLEEIVLKVCEIKQWTAEDGARRLKANWMRFIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY12</accession>
    <name>A0A1C1CY12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carboxypeptidase S1 A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SCPA</name>
        <name evidence="8" type="ORF">CLCR_09745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY12"/>
    <dbReference type="STRING" id="86049.A0A1C1CY12"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09745"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00390"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF64">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651145" evidence="7">
        <location>
            <begin position="20"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="614" mass="67936" checksum="4E050803D7DA6B14" modified="2016-11-02" version="1">MFWLSTAVLLAIVSPLTLAQFVTPPKNLTSKTGYADVTVRYKSVPAGICEQDPDVKSYAGYADVAPGQHIFWWFFESRNVDPTEAPLTIWINGGPGSSSMIGLFQELGPCRVNEDGEAVDNPYSWSNVSNMIFIDQPTQVGFSYSTPVPAYEDPNSGYLVELPTNNCPGYASDWACGTYSYWNESLTANNTPAVAPNMWKTLQGFMSAFPEYARQEINFATESYGGHYAPIVSEYFIQQNALNISGAQNINLQHVLIGNGWYDPLVQYQAYYNFSVSPGNTYNVSPFNQSVKNQWYNNLYGPGNCYDQTLDCNTRGIDEICSAADNFCFQQVENLYDIYLNRDEYDVRYLVPNPFPQSYYIDYLNTARVQAAIGAYVNYSESSSAVGNAFGSTGDDDREIGTVAAMQALLAHNVSVTMYFGDADYNCNWLGGAVVADHVSAPGYAAAGFTDIRTSDGVVHGQVRQAGNFAFIRIYESGHLVPFFQPLVALELVDRTIRGLDVATGRNPITPAYRTMGTDTSTFVEGNRTVQFKVTPEGSVYNTTTNLPQTGGGGDDGTGDPPKSSKRASYNLKEARRIKLERRTRRRTRSTMDQSEAKRSDDVNVNFSGWWVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY97</accession>
    <name>A0A1C1CY97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY97"/>
    <dbReference type="STRING" id="86049.A0A1C1CY97"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10843"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00480"/>
    <dbReference type="OrthoDB" id="5331396at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="155" mass="17740" checksum="0DF5942A2DF11976" modified="2016-11-02" version="1">MASRAFVPRLSSASRAFRAFPQFHSRSFQSTSRQFQEAATAAAVPVKRPVGAFRGGLFGFLLGSTLAGASVYYYILEEYKVSNELLTEDIYRARQPPLRQTLYMGHRRLLSTEYRPHLHHKRSTLIPRHQALQAAVQRIHSYVTELENKMGQMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYP6</accession>
    <name>A0A1C1CYP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative esterase C31F10.02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYP6"/>
    <dbReference type="STRING" id="86049.A0A1C1CYP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10948"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00610"/>
    <dbReference type="eggNOG" id="KOG3328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000033">
        <property type="entry name" value="acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF11">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04355)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="57"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="154" mass="16280" checksum="A56891A5371C4FD4" modified="2016-11-02" version="1">MGSVKTPFDYVQACWARVQENSPVYKFFFSDINIVSAESGSMIARLPVSANLLNSKGGLHGSVSATIVDWAGGMAIASTGMEKTGVSTDIHVSYVSSAKLGDVLTIEGKVSRVGKNLGFTTVTILKGEGENQSVVAHGTHTKYILRDQPPSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ87</accession>
    <name>A0A1C1CZ87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_10409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ87"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ87"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10409"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00778"/>
    <dbReference type="eggNOG" id="ENOG502RDNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF13">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT53854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="323" mass="35923" checksum="5D3870DEA8FAF665" modified="2016-11-02" version="1">MAVPSDISYWVYKPTKGISIAFAVLFFISGVLHGWQNNLKYKGSWRVGFLFPWAAALFVAGLITREYGAYHTDNLGVFVASTVLLFIAPPVYNGADYFIFGRLLYYVPYLSPIHPGRVWTTFVALDAIDGIIAGNGASYAANTENSLSKIKMGVILVKVSLFLLLGMANVFSHNVKVVVYSLYLSAFLILIRNTFRTAAFFYPPDSTANGKEWIFWVLEVVPMLLNSYLLNVYPPLKYLPRNDKIYLAMDGKTEIEGPGMVENRPFLLTLVDPFDLVGLATGQDNKNRFWEHDGIGGPGGSARRANEDEPESVHASKEIHSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZB9</accession>
    <name>A0A1C1CZB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Vps45</name>
        <name evidence="8" type="ORF">CLCR_09927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZB9"/>
    <dbReference type="STRING" id="86049.A0A1C1CZB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09927"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00805"/>
    <dbReference type="eggNOG" id="KOG1299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="593" mass="66778" checksum="FA72B07AA0FCDD0C" modified="2016-11-02" version="1">MDVSSAIAGYLSKIAGVGEGAAASQQTKMKLLLLDSETVSIVSTAITQSALLKHEVYLVDRLDNPARERMRHLRCLCFVRPSPDSIQFLIDELREPKYGEYNIYFSNIIKKSSLERLAEADDHEVVKAVQEYFADYIVVNPDLMSLNLGFPKQRLWSHSPDIWNTDALQRTTEGVIALLLSLKKNPLIRYQKNSLMAKKLATEVRYQITQEEQLFDFRKTDTPPLLLILDRRDDPITPLLTQWTYQAQVHELLGIHNGRVDLSAVPDVRPELKEIVLSQDQDPFFKKNMYQNFGDLGGNIKDYVDQYQTRTKSTAQIESIADMKRFVEDYPEFRKLSGNVSKHVTLVSELSRRVSAESLLDVSELEQSLVCNDNHANDLKTLQRHIQNPSIPADNKIRLVALYALRYERNPNNALPVLLDLLTSVADVPAHKISIIPKLLAYHHSLQPAPVGGASGFIDLFDSGSSPFSQFRRNLNLKGVENVYTQHSPRLETSLQHLIKGRLKELQFPFVDGHHTKDKPQDIVVFIIGGVTYEEAKMVAQVNASVPGVRVVLGGTSVVNSTMFLEEVDDAVSSWPDQGPATTRERLGRAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZG6</accession>
    <name>A0A1C1CZG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZG6"/>
    <dbReference type="STRING" id="86049.A0A1C1CZG6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10253"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00827"/>
    <dbReference type="eggNOG" id="KOG4044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="190"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="382" mass="41561" checksum="25EB43218E810026" modified="2016-11-02" version="1">MQSSVIARTRFCLRLPISCPKPTRRVSSVSAPGFARNQHTGKPVADHRSPTREIPLPGAVTEGQARKSTTKTQAALLFADFAPDTTPAPHTPQSPRPRPLSVVDGDLIRKTPSNVEAEFDPEAESQADFDGRSPIRRHVVRSKVHPFIRKTSGPRKEISALFREGSLNKRASRNGLDSMSVNSKRIANPVLFICDVQEKFRGAIWEFDKVIKTSQKMVKAAKILNFPIFVTTQNAARLGDTVEEVASLLPEGSASAIDKTAFSMLVPDLQSHLEKLAAGNEKLSVFLVGIETHICVTQTTLDLLSGGHKVYVLADGVSSCNAAERPVALNRLAREGAIVTTSESLLFELVGDAKDGNFRAVSGLVKETKEDTKVAVETFCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZX4</accession>
    <name>A0A1C1CZX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nahG</name>
        <name evidence="5" type="ORF">CLCR_10199</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZX4"/>
    <dbReference type="STRING" id="86049.A0A1C1CZX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10199"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00900"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF1">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06050)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="11"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="430" mass="47962" checksum="25B6BB04800E1513" modified="2016-11-02" version="1">MPSAIDRPPLTVAVIGGGIGGLCTALSLKHHCGDLVDIDVYEQAPQYKEIGAGVGIGVNAAKLLHKIGLGETVSHIAGKRSGIWIMFRKFDDGSEVVTVPSVDTEEVKQLPVHRAEFLDLLVDVVKQRRAARLHTNKRCRKLTEQGDEVLIEFEDGSIAKANLVIGCDGIHSAVRAQFTSDNPEYSGRIAYRGLVPISEIESWWGFPTYSVTWLGKNRHFLCFPISQNKTLNIVAFVAEDEENLGDLRESWTEIGKREDVFEAFKGFEERVQKVIQLMPEQPSKWLINDRKPLDQWVYLGGKAVLLGDAAHAMTPHQGAGAGQAIEDGYILGRALQDYFQSSSPKEGALEAWAKLYQDVRLPRAQKVQRGSRDAVEIYQAQADVMKDLPFDECVPEIHKRVINRMKWIWTDDIDAEYDQAVKAQREAGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D067</accession>
    <name>A0A1C1D067_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-methyltransferase FtmD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftmMT</name>
        <name evidence="7" type="ORF">CLCR_10170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D067"/>
    <dbReference type="STRING" id="86049.A0A1C1D067"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10170"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00919"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF5">
        <property type="entry name" value="O-METHYLTRANSFERASE ASQN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="6">
        <location>
            <begin position="184"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="436" mass="48368" checksum="AE2CF0FD3F264C95" modified="2016-11-02" version="1">MCQLETLAQTVSTQAQTLSRSWHEGKEHALSSCDSRRTTIPPLDPQGEEARNQLLAAIRTLEQLVLGPKDTMQSFYYKTAEAGVIQALCQLQVPRYVPLYGSISYADLSKKVGVSEDRLKHLIRIAAVCSNFLAETEDGQVKHSDNSLIWQLDPLAATGMEVMLDHLPSSSFKLGDVCTQDPMDEKQEVCGFSLARQQPLYLYLETHPAEGRSFAAHMRAQAAQYGDSAIQECYDWSGLTGKTIVDCGGSFGSVAAAIVRKEPTIRCIVQDLPKVVDSAIKATAQDPNFPHESISFQAHSFLETQPVVADVYLFRMVFHNWSDAGARRILQALRPALRPGARVICIEYVMPPIGTAPSYAELATRRLDNVMYTLMKGKVRELSEFKDLFESMEPDLVFASFRQGQLRATHDPRCHSVLEWVYKPAGALGDAQVHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0J5</accession>
    <name>A0A1C1D0J5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative prefoldin subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_00209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0J5"/>
    <dbReference type="STRING" id="86049.A0A1C1D0J5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00209"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02534"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT54160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="122" mass="14103" checksum="066F7AF765B98FE9" modified="2016-11-02" version="1">MASGQEAALRKQQGFNRAENMPDLQSQYSNYKDTLQSLAQKVGEIEQEIEEHKLVMETLEPLPQDRKCFRLINGVLVERTVKDVLPALKTNSDGLKQVLEELLKQYKAKQDEMDKWKVVQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D179</accession>
    <name>A0A1C1D179_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine carboxypeptidase S28 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_00823</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D179"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00823"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01690"/>
    <dbReference type="eggNOG" id="KOG2182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651193" evidence="6">
        <location>
            <begin position="21"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="537" mass="59570" checksum="44E9242109A92F20" modified="2016-11-02" version="1">MQSLRALLLALTASLGLAAAQVGPLGKNGRPTTYTAYTFDQLIDHFQTSPRYAPNTNATFKQRYWFDDTYYKPGGPIFLYIGGEVSGTSRFSNLETGIIQILMNATSGLGVILENRYYGDSYPFENSTTDNLRFLTTEQTIADNAYFAQHATFPNVTGGDNLTAAYHPWILYGGSLAGAQTAFSLVEYEGLLWGGIAASGVIHAVLGYPEWYNPIQENGPSDCISRINNIIDKIDHLIDTNNTAAIQQLKEIFGLGTLSDLRDFAMTIAFPLGGPMNYPTNTWQELNWSPPSDNPDFFWFCNNITDMNAPANITAVDTQLANYTNGSAWTGLGAYANYVKEVVVSSCESEDLINTPECFSTQNQTFYAITDNSGSRSYLYSTCTEQGAYQMPQPRGTPSLLSRVIGLDYTQQWCTWAFPPGPLSPQAVPSPDGPNSTWYNKYGDFNLTAPRLALIDGGSDVWRDLCYHGRNASTRYGENQLLITGGGHHWDSTGILNISAEPDFIREAHRWEIRRVKTWLKEWDATKGKHAVKRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1L7</accession>
    <name>A0A1C1D1L7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1L7"/>
    <dbReference type="STRING" id="86049.A0A1C1D1L7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02880"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04685"/>
    <dbReference type="eggNOG" id="ENOG502SM9E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5313079at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="563" mass="63860" checksum="7ED5387EB5809903" modified="2016-11-02" version="1">MGLNPNGRNWGSLVNWDDLGKFYAGFIVAWTVILYAGVAFLIINRNLAFIKIRNQPLAIAAVSFLHVYLVKIFLAYTTNGHFLCSAEFWIMSIYLPFGIALFQANLAQLRSISDQQRDLVYTKHGSFDGQSSLSAAQQVRYRWSSLSGIQKSYVYVGTGMTVQLIITAALYATTPTLQGDWSSYGDVSHAKGQALCRKSPEWIPSAFWQLAWSWLYGPYLLFRVRNIHDVHYWRLQVIYSVLSGLPGAPLWLAALYSTAFKPVNRWWVPPMWLAPGIVVMQFTTIFFPIYEIIKSRLQLRQTLAILELWEDRRGIRQSSDHADSSRASSDQPSITSSQQRDLYTMASLERALADNPNPLLKFAATRDFTAENILFLMQVQRWKETYASALRANNTLSESAKSQLFHSAVDIYISRVNDKTTDFPINIESRVRQDLDTIFGPAVPTGRFDPDEDMSYYEAESWIKSPKTTSTFHLDNSAHSGASVETLTAIQVLMSFPVENHESIFPPHPGVAPLGESRARMRAGFDEHVFDAAQRSIKYLVLTNTWQKFVKEQQPSIDIRIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1X5</accession>
    <name>A0A1C1D1X5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_02798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1X5"/>
    <dbReference type="STRING" id="86049.A0A1C1D1X5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02798"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04884"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000260">
        <property type="entry name" value="Forkhead transcription factor (Sep1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="208"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="208"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="720" mass="79256" checksum="B2CD12ED1556DBFD" modified="2016-11-02" version="1">MASTRPHPLVQIYQDPMPPPPTSVSPVEKPPPRLQPSAMPLQPMRNPPAASRHPAVILAAPMAPCHQLSPQKTTTLSPSRPYFGDLNYVPIPPPPVANHSHTGSPTKRTAMLHSQPPRPAQMVQPMFTTFNSNFDTYEQENFPAPTIHENFVDFPEPSYPRKQPMKRSYSDAQLSQDRPFKKTRQDEELTFHLPEPEDMMPVEDDGNKPPYSYAQMIGMAILRAPNRRLTLAQIYDWISTTFAYYARDTKQSWHNSIRHNLSLHKAFTKQERPKGDAGKGSYWVIVPGMEAQFIKDKKPRGNMLAPMYNLPSVVRPQPQIAQQLSEALAPNAYLGQSSEPPRPQTAPALPELSSDATLPASDAALHEHETADLEDSATAPAMKSPPPDAINSSPPVVVSNHHRAISSPSARMPRSAASHRQAQSLTKNDDSGYFSSIESSALKPNKNTVVLTSELDIEPMRKKRGRAEEEIVRIRSSSHDLTPSHARFRPCTAEPPQSSSPVRVSPAVTLNPMTPAVVFKKPIRPPPSVSPNTQLLLHRKAMREFANSPIKGSGLFMSDDTGYSPLKWPSLTASELPESAFEIFSDPAIGLTPATPPFASSPLKRPSVARAVTSTDVLSDVFSHGYKLNAKTPTRGSLLNPRVRATHNGSPVKGSTAHIQILDQVDDLFDFKSFENDNSDDNDEGVDILQGFEKIGVPNAAMKSEHGGRPSLGRSFTSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1Y7</accession>
    <name>A0A1C1D1Y7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Ribosomal RNA-processing protein 36</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">rRNA biogenesis protein rrp36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_02812</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1Y7"/>
    <dbReference type="STRING" id="86049.A0A1C1D1Y7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02812"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04838"/>
    <dbReference type="eggNOG" id="KOG3190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT54741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="658" mass="73988" checksum="0DED2DE9EFFDA105" modified="2016-11-02" version="1">MAPLRLADRPVRPRHEHEEDEELELSNEDVSDEAQSEREDSAESDSQSEEKDTALSSDADGDDEEDAQDEQPSLADISFGALAKAQETFNPKPRKRKFAETGEAPMAHDDGRDGDEPFDTRRRAKEARLDAPKRTSKHAPTVESARKPVSRKRTIFEPPPSAKSRDPRFDPTVMSTNRAPGAAEKANKNYSFLSQYQAEEILELKTQIKKAKDPDVVADLKRQVMSMESKVRNAQSRQREAEIRKKHKEKEKEALRSGQKSKPYFLKEADVKRLAKQERLESLGKKARDKAEKRRLKREKGKEARDMPRYRETCLLWFQLHINHQLPANPLVIVLHQTVQLLKRVRPNPRPDTVLGRKIHHSLQLAIPPGQDAHQLDVPKDEIAGLELPAVLGETHRDADAVVLQHGHAEVKRRLRLRQDDGRVAALFALEALRRGAEDAFLGVVHRLLERIHDVDPLAVLAELLDHLVQHPHRRRSVHGDDVPPQLRGELHAQMAKPTPGAQDGDVLALSIPFTFGRLHARGLERIPNRHARTHQRCDVHGSHPPSLRHPRNLPAINETPLLKPPISRHPEVSSACTPDPISGHIPVVVHALGTFSTRVERASRHADQISLPQAPFLRDFFGIGTERVDYAGEFMASNAGQTLLHGPGDEDGVRMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D208</accession>
    <name>A0A1C1D208_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D208"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03129"/>
    <dbReference type="OrthoDB" id="10380025at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="194" mass="21664" checksum="8EB549A82905FBE8" modified="2016-11-02" version="1">MAPLKRFESPIFGGSDDKVSHADSVPHYNSVVDLEFGMEELTRPLPEYSLARPFPPPRESQVDGAIGTPHVEMRDLSAHGHHTEDTIQRRKDVPQRKRWRALLLLVGWLLLVLASVACVARISILVRRRELVDTIEATFWFLVQFACLFFPLARLVVRGVAVAGPKASRGRRFYAQTVALLSLATAIGLPLGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2B0</accession>
    <name>A0A1C1D2B0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prolyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2B0"/>
    <dbReference type="STRING" id="86049.A0A1C1D2B0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03088"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05030"/>
    <dbReference type="eggNOG" id="KOG1454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="36"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="279" mass="31524" checksum="60EBD2DC9E500D89" modified="2016-11-02" version="1">MSTVSSLLTPGEHEVKLNDLSIHYTVQGSGPALLFVTPGWGINRSIYATTHQPLEEHFTVIYLSPRGCDGSERPASASLMLSRYTASDIDEFRKQLGMDQLNVIGHSDGGVLALAYAMYYPLHVRRLVPICTSLLGYQRKDTSFFTQFKAMFEAASPQDDDAFREFMLSAFYLYFYKPEPYVPKLKDVWTGKPSLWANRARYESEAEDGWIMEKDLGKIDAKTLVITGRQDTCCGPEVSETVARGVKGSTLVLFDECGHLPWLEAREEYFDVLVRFLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2F0</accession>
    <name>A0A1C1D2F0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2F0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03223"/>
    <dbReference type="OrthoDB" id="10011777at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="81" mass="9256" checksum="6D130EAFFE85B03E" modified="2016-11-02" version="1">MPYWPEHRKGERYHALLARTKDEDLLSGPPDVKILQPVGRVSGSDVREEDSKASWRLSIVVGHSQRIWPGDLLEAMTQKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2S1</accession>
    <name>A0A1C1D2S1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_02767</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2S1"/>
    <dbReference type="STRING" id="86049.A0A1C1D2S1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02767"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05123"/>
    <dbReference type="eggNOG" id="KOG2176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.30:FF:000004">
        <property type="entry name" value="Exocyst complex component SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="8">
        <location>
            <begin position="50"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="7">
        <location>
            <begin position="401"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="775"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="781"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="798"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT55031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="833" mass="93276" checksum="AE6A75648DAF7E93" modified="2016-11-02" version="1">MPSIAPYRNDMNNVLQQIVTSSSETDTLDQLIPYIKDYSFGNKTAHLLGQLSDLAGEREAEIERQCNTNHQEFVKSVNQLLRIREGTVTLTNEILELNQSIQASTERLVDQKKALVESRGVRQNIEDARHALQDCLEVLRLANQVQELRDQKKHYAALRALDELQTVHLQSVTQYQLSELIQKSVPATQKSIAEAVMADLNTWLFRVREMSQYLGELSFYHTDLRKQRLKERSEKNPYLANFKLNSAIELVADEHEEFDLLKSEDLEVDFTPLFEALHIYRSLGQMEKFKTDYAASRRAQRDLLLQNSISLVDEEMGDLHTLLEDIAGFAIMERATMKKVPDLRSTTDVEELWDSLCQTAISLMSRALSAVDNAEHLLKIKNLISLFIQTMNKFNFNTAAMSNFVLVLFDKYAELLKQRFSEDFIEIVSTDDYMPMPIQNAEEFEKVVNVSWYTPDRPAHEMTFPIVFPFSQMYPLCCIDIRNFLNQFYFFSAQDDNAPSPLSQKIDSQLLTSLDDLLTTKVCASLVSKLSSQYLGQIVQILINLSHFTTACHELESLLASARSSSSSSSSSQTSTRNGTSSSSAATTMGPSISLKATAQFSTHQKTAENRIFELVNSKVSDLIETAEYDWLSRDPPTEPSNYILTLTRYLANIINSVLLSLPSSLKDLMLFNAISHTASSILSLPLSDSVDRITTATIAQMDMDISHFRSYVETLPNNVVLLESLDELVQTIALMRTDQPDEFYDISLRNKKYRNVDPLKGPMLLEKVVHVDMGRSPTSAGGGGGGGGSGPHGSGQGAQSAGLGHSGSTGSRTGGTTTTFGALRDRYMHSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2S5</accession>
    <name>A0A1C1D2S5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2S5"/>
    <dbReference type="STRING" id="86049.A0A1C1D2S5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03175"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05072"/>
    <dbReference type="OrthoDB" id="5422510at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="138" mass="15061" checksum="91C89C354DF5812F" modified="2016-11-02" version="1">MASEKPSSITLPPPTTSGRQISPSPQGLRQRPLGRASTFAEGNPALNRRRSSFLSETFSETRKSLRTSTDDILLPRAKDEDGFHDHDDGSHWQSLPLGLALLPAVGGLFFKNGSAFITDVTLLGLAAIFMNWALRSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2Z2</accession>
    <name>A0A1C1D2Z2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_02903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2Z2"/>
    <dbReference type="STRING" id="86049.A0A1C1D2Z2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02903"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05109"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05110"/>
    <dbReference type="eggNOG" id="KOG3482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Sm" evidence="6">
        <location>
            <begin position="130"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT55018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="216" mass="24329" checksum="F223DE96C38447B9" modified="2016-11-02" version="1">MLALTLSAELEGVTDLVPSDTAESPYYYTFKVQCTSCREIHANWVGVSRHRESSATIKAAPAKYEQHSPAKAKNLIEMDCRGLEFTDFKPDGEWEATGVESGTKFHGIDLSEGEWFDYDEKAGEEFTPLNPRPLLQSLINEEVIIRLKWGQTEYKGRLISVDSYMNIQLSNTEEYIDRKHTGTLGQVLIRCNNVLWISAAKGVEMNGEGPDTKMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C691</accession>
    <name>A0A1C1C691_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Citrinin biosynthesis oxydoreductase CtnB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT43988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C691"/>
    <dbReference type="STRING" id="86049.A0A1C1C691"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00130"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02057"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF3">
        <property type="entry name" value="ESTERASE DBAE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT43988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="251" mass="28261" checksum="0AA32D45F2620EDE" modified="2016-11-02" version="1">MASADPTLHLPRVLCIHGGGVNAAIFKAQFRAFLNHDRLKTRYRFVFVDAPFFCDEGVGVHPVYSYWGPFRRWFRWTPEHPEIDAGACQYELEYTVERCMESDEGTGEWVATLGFSQGAKLAASMLYEQQVSGKDGPWKYAVILAGRAPLVSLSEEAEEFPWMQSAGGLPDAADTESILERPDMKLRIPTLHVHGLKDEGLHLHRKLVENYCAPGTTTLVEWDGPHRIPIKKSDVDKIVDAWIELADEYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6C7</accession>
    <name>A0A1C1C6C7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6C7"/>
    <dbReference type="STRING" id="86049.A0A1C1C6C7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00102"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02020"/>
    <dbReference type="eggNOG" id="ENOG502S5P0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5397087at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="472" mass="51105" checksum="AF6DC9BF5AD41C7B" modified="2016-11-02" version="1">MPPMKNTPPAKAVKTERTHEENQERAYIAASRRSDRSLEARVESARRASEIHKRRTGRSLRVTEQDVINEEMYEEEDDDLPLQYRRLTEHLQTGSADFNRRLAAYLTNQVAMRTAMEQMVQGPYGLHGGRGYQGSSGMFPSPMLPQQQGMVQSPSAYQRPAPYPSPHHPSFRQAHGRAFSMQAMPTAQGMRSPSASVQQLSTDNRRLSTPSSAHPDLSSGPQIQTDGLKADPEYQRQTQSATLPQGGLGSNGPMPFWRDMGPFTTSLPPESQQMLAQAPGFDVRDPDYAMLMHGSEQFINDPYYPWQNMHGGIKGMPVHPSAYPGMSATLAPAALEKNADYVVRQPGTNVSTSGSGPTSAPAAVTDALPSAGLDFKFSQESKEPAFSAIAGDMAISSGQVTPAGEGFWDHFVMDGSWEDSAKETHHPGADSKPGDDNKPGGDGIPGVDAMPGSNLRSVEIGSGGEVDRKHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C706</accession>
    <name>A0A1C1C706_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C706"/>
    <dbReference type="STRING" id="86049.A0A1C1C706"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00667"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01173"/>
    <dbReference type="eggNOG" id="ENOG502S26C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF9">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40493" checksum="B338D96A8C39C2BA" modified="2016-11-02" version="1">MPVKKGQVRAVPLAIPEPGADAAERKRVLNVLAQRRYRQKRKEHIRKLEAKASVADQPHEAPQLDSFSDPRAPPELDDQAASDIQQPQCPFAAAHLYPFDDGPVLPNDVDLAAQTLVSPGDPFSNILPEDQGLWDTSILLPSLPSTPLSTSKHSSSGESETWSLTPPAVAKSPPEWQATSQPADFAAGDMTFSFPDEAYLEMTELTLLRGFMAIARRLNVHDEVWSLTAQSPFANSAAAMAEFNHLPANLRPSLLQLTVPHHPIIDLLPWPSTRDRMIQVLMQPPEFRPPSAASPMALLDFVYDVEDSAEGVRVSGDDPYSANNWEVGEKVFTSWWWVFDKDIIMRSNELRASRGAPLLGGSILGEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C746</accession>
    <name>A0A1C1C746_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">linC</name>
        <name evidence="3" type="ORF">CLCR_05961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C746"/>
    <dbReference type="STRING" id="86049.A0A1C1C746"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05961"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06978"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42820">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42820:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="309" mass="33480" checksum="8F705E1B301FEF64" modified="2016-11-02" version="1">MVFRSGPVAPGVAFVTGGARGLGNAIGVSFAKEGARGVCLVDIQDDATFEEGKKAVEKYGAKVLCIRADVTKEEDVERAVNEAVKEFGRIDYAANFAGIFGSTLPTWEMPADAFRQVMEVNTTGVWLCNKYQLRQMMKQDSVEVEEGRPPQRGSIVNCASVSESPCSSKFETVASQGLQYLCFQRLWIEAKDSADSIQAGAGTTGYTAAKHAVAGLTKAAALEARGHDIRVNAVSPGFLLTKLLDPFMEKYGSEQGMKQWEVHEKRQGRKATFDEIGDVVVLLSTPRMSLVVGHNLVIDGGFTINERTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C788</accession>
    <name>A0A1C1C788_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C788"/>
    <dbReference type="STRING" id="86049.A0A1C1C788"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05944"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07087"/>
    <dbReference type="eggNOG" id="ENOG502QTKU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000911">
        <property type="entry name" value="Chromosome 8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF7">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="369" mass="41016" checksum="88FFC83A66079611" modified="2016-11-02" version="1">MTAATRIVKVGIIGCGEITQVAHIPTLCFLSDLFTITYLCDVSAETLKHNAQKVVNHIPQTTQDPAELCASPEVELVFIASSDEYHAVHVIEALRHEKHVFIEKPMALCMRDADAIIEAEQRSKGRVMVGYMRRYAAAFLDAVKEVGGMDKILYARVRDIIGPNSHFVAQSGTFPKVFTDFSPEVVKDKNDRASDVAHQALSVECGLAVTAESTKMWRLLGGLGSHDLSAMREALGMPQRAIGASLKLPFWSALLEYPTFSVTYESGLDNVPRFDAHIEVYSMTKTVRVNYDTPYIKGLPVTMTTSENIDGVYKESTIIRTYEDPYTLEMKKLYQMVANGKEVKTTAKDARKDVEIFQMIMKAGYGSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7G8</accession>
    <name>A0A1C1C7G8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7G8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05531"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07104"/>
    <dbReference type="OrthoDB" id="10500616at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="753" mass="82691" checksum="F00E7C7009CBEA03" modified="2016-11-02" version="1">MDQAAEPRQVESKAKFIQQDPTSSQYNGRITKDDEAMLAALLPTLHFQGVNREQMLVECNAVLGTPITFAQLDRQRAKFGLHKYRRQRPTLPSQTQRSHNIAPQSYDEEYVGGLGSGTESETIGACCANQPQHVGASNALQIENAPRLTDTAMLDDPYNDHGGAAPQPGSITDLILSNVGTSPTLETCRASLSLQGSDPAPFNAHVPKPLQSDMTDHRSAVRPPSRFKLICAHALRHQAFIYHIHSVSLIRIYREQLSSGNAATDIAQVAEIATLLHTVKAFDQAFDLFCMLFAYFHINTSIRFRHLHMTFATIACAQSAQSDLQFRAAYGMIKCVYGGFAPLTPVGSFSSRVKSALADLGHRLESVISGWTRRLQPGILEGVIFGAFAALGFSHSVTRHNPLSKEWDPQSGPGDLLHVAFSDEFLGDCFLDGMEIALSILEGQLDELDVLTKDAWKFLDTTATSIARRLACAVLKAYARQGPTRAARATKQFPGSQNRHVRWTIVTVALAPFVLLSKTGRVGNMVEFIEAARQYQHGILSNRARLDELGRSCRLQLLLLAVENPCDALSLSPDEVVEICASVARVRISSDDLAMGMSPPRLDKAIPSLEEESLLGIGPSQHQYSYVPMPPLDWIEARPMEQVPVPSPSLLSALSEVALSGEIREQSSVLSPTLARTYTPSNSSSLRSFLSTAERLRRRRTRFSDDGLWQDAVSESGTSHSSWRFSFMSNAPPSTFSTRRSVQTVLSDIEMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7T3</accession>
    <name>A0A1C1C7T3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative glycosidase C21B10.07</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06029</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7T3"/>
    <dbReference type="STRING" id="86049.A0A1C1C7T3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06029"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07235"/>
    <dbReference type="eggNOG" id="ENOG502QUM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF58">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE XGEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="364" mass="39208" checksum="8084725C9063C273" modified="2016-11-02" version="1">MRPSTLVSALLAGGARGLSNYQPVGNYSGVDFFRNFQFFSDPDPTAGFVKYVDQDVANSTGLAGIASGDQFKDLPYLGLDYSSVAQAGRPSTRIESQNSFNSSTLWVTDIRHHPGGVCGVWSAYWLVGPNWPWGGEIDLLENINLATTNKYVLHTGANLAVSNLSDPTTANSTGMNIRGHFSNLNCSAASEGNVGCVVEGQNNTFGTEFNANGGGVIALEYLPEAISVWQFARTEIPGDIFNGSPTPSTWRRPDAHFMATDGSSLEDYFYSLRTVFNTNICGSWIDKVWQTSECAALAPSCAAYAAQNPAAFKDAYWLIGGVQVYEAVASDVNATALPEVPAANLTSDLNNRGHVRRFSRGHVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7W3</accession>
    <name>A0A1C1C7W3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MTHFS</name>
        <name evidence="7" type="ORF">CLCR_06232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7W3"/>
    <dbReference type="STRING" id="86049.A0A1C1C7W3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06232"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07247"/>
    <dbReference type="eggNOG" id="KOG3093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="7"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="163"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="228" mass="25585" checksum="C46EF28FF89A044D" modified="2016-11-02" version="1">MALKEQKSALRKRIAEKLKELDSEEIERQSAIVTKKVIQMRAYQEAKSVAVFLSMPGREVSTREIVLHALAEGKSVFVPYLHPGQRPKSKIMDMLQLQDKEDFHSLKPDAWGIPSLSEDSVGRRRNALGGFGLSNESVDNQQATPRLDLVFMPAVAFDRAHRRLGHGKGFYDRYLSKYKNALDSGSTTRPMPALVGIALRQQILAPEESLPADENDWPVDQFVVADVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7Z0</accession>
    <name>A0A1C1C7Z0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-hydroxyacyl-CoA dehyrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_05945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7Z0"/>
    <dbReference type="STRING" id="86049.A0A1C1C7Z0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05945"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07302"/>
    <dbReference type="OrthoDB" id="2021159at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050104">
        <property type="term" value="F:L-gulonate 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF1">
        <property type="entry name" value="LAMBDA-CRYSTALLIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="5">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="5">
        <location>
            <begin position="181"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="239"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT44630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="412" mass="44567" checksum="929C7E76C3828B8B" modified="2016-11-02" version="1">MSPEEKTTPAAAAAALPHGDQHIALIGLGAIGISFLALHLTYTSATISVYDPRPDLQDHVASMLPLYMPRGGGGGGGTTRSDTDTDTDIISSLVTSRRLRFCTSLGDAVSRATIIQEQGPETLSFKQSTWSEVLRHTASITPAPHLWSSTSGIPASKQLEHLQQQQQQEGAVSISDAVSRSARSRLLVVHPFNPPHLMPLLELVPSPHTSAEAVTFAESYFRAVSSVHQPITIKRETAGFVANRLSFILFREACSLVARGVCTVEELDEVVRASLGPRWAVGGPFRMYNFGGGPRGMAGFLDNIGGAIRGVWEDVDRQGRQGGSVMMEGMGVHERGHEGGRESVHGGGRDDEEEAAVRDWKRIVTEQTIQAYGVPSPQDVRARDHALVEVVGLQVRLEAESKEKEKETRSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C806</accession>
    <name>A0A1C1C806_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_05341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C806"/>
    <dbReference type="STRING" id="86049.A0A1C1C806"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05341"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07336"/>
    <dbReference type="eggNOG" id="KOG0443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025118">
        <property type="entry name" value="DUF4045"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057226">
        <property type="entry name" value="DUF7904"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF133">
        <property type="entry name" value="DUF4045 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13254">
        <property type="entry name" value="DUF4045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25480">
        <property type="entry name" value="DUF7904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4045" evidence="2">
        <location>
            <begin position="9"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7904" evidence="3">
        <location>
            <begin position="1349"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="946"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1527"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="970"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1539"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1555"/>
            <end position="1573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1708" mass="181737" checksum="AC697D9B8E610CEF" modified="2016-11-02" version="1">MDASNDGAESVDQFLARIASLSSKQTAEEAERSKRTEEELLQARKERQARRLERARSLSPSKTGPAASLRPTREAASKPTQSIEPPIALTPPLQPRTLGRSGSTSPRHDRAPVTGLDFSRPLPAPPPLTDDEPTLPSPPAHATTLSRSGTLSWNQRPLSRGGAVRIRPMSVASIPDLGTPTPSAADQQAEEEMSRKDIAASLEARDPSWFRQTADRGIGSAAYRKHETDSDTMTASASRGMRLPGMSNATEDRSKEENGKATPPSSPPKSAHALSSSQRQPSSSDRPRPRPVSMVSSSPSKSPALDLPTFKPLDLNTSFAVDSPGLGRTSSILSSSGRPPSPTKGLGGFVESAMMKRSDSVSKRWSVQASAGLKRGDSVASTRPPHLATVSGYTPGHSRGSSRDVRGSRDGNSSPLSSSRPVSSHGEPVAITRGRSLPRPEDDSAAAPNITPKQEAPGETGKASDLPPQTRPVTPPPTDTLLSRSPSKTMDPRRWSPTKASWLESALNKPPESPRAAKSETPAWRLSMQRAKQEQSQSSEAGEEALTKPVVAPKALSTPSIKDSKTVERAIADGVAVDLSSREAGREKSNSTPLPSSDASDASKTDKSFTSTTGEKPSIPSKRNITPVQLGSSSTQKVMSTSVTPLQDEQETAKGPQNPTFREPKLGSKMPALKPKPTTPPKPDFRASLKSRQAAPTGNNNAEPEFKAVFGKLKRAQTQNYVAPDELKDNITMGKAALNVTGGPQKTKRVDEFKESILQKKEAMKTGGGAIGKRPEATSPTEKHNDPVPEALAKRMALQKTGTSSEKAESKRQSDMPAKPNVSAIEPRAVGEKPTLSGLGTKPSLGGSKPRVVHDKQVPAKGEVLAQSERTSAPPTVLASNLEKSHAAPVTVLPLRSASDVPTRPSQQNPEIKVAEPAPSSESGSRVKLPENSKLAARLNPALAGILSRSGSPKLPGDASSNGRGGIQVRDTHQNPRDSTKEDPAELTHMTKARSKGPKRRAPKTAASSTASGKPPPGQPATDSTSVSPKVIGSPESALGSTASLSPRSFAPKPSASKPTTGVQNAEVGVREVQRSLPTPPTAGIEKPILAEAKQSYPTLTKAELPKPSIANTAVVKQSINEPLPTSQPESESKPKPIVANKSAELRRVSNQGAPAETVDMPPPLKPKKSADLRKVSNPGTHAKPATPKKIEVLPDTSKLVTSPPDSDGEKKATALSPAFAPGLPLTPNKSKLNTPKTPKPDIISSTKPRPVTPPKANGLGLQLGTGSRKLVAAPVLTPPPEPQPLATRAAGSSRPFSSPTISSPSVRPQLESFFGVLPRAGERAEFDTHAFLSAQNKTPEKSKTLNKQIWEVSGDGKKTPMPPQQEHILFENCMYLCVHSMQSPSGSKLSEVYLWCGDEVPEAAVEDAQLFCRKVARENSAKLEVIKQGKESSEFFQALGGIVIVRRNKSSALYMVCGRRHLGHVAFDEVDLSADSLCTGLPFLISAKFGKLYLWKGRGSNPEDVGCARLIGMDLGLTGEIEEVSEGEEPASFWDSLPSGSSKRMLSQSSSGAGERDSQPPRLYRVEHDRPKSSGGLGGFWGLRASSPPKQSLKALVEEVAPFSQKDLDGHHIHILDVYRELYVLIGGFAKKPAEFATAVQVAQEIAVLSPSVQDRPLLPSCYVVMGEPPQHIKSIFRKWTPQKPSAPGEQLCVRVEEVVQELGIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C812</accession>
    <name>A0A1C1C812_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_05870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C812"/>
    <dbReference type="STRING" id="86049.A0A1C1C812"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05870"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07322"/>
    <dbReference type="eggNOG" id="ENOG502S4UR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="7"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="410" mass="44447" checksum="225224CFA66C1FF9" modified="2016-11-02" version="1">MSLDVKLAQAVQDGVIPGAVLLAASSSGHVNYANVVGRRSLRVGVEDPLRLDTVFTLASMTKLLTTLCVLQLFERGALGLDADVSQHVPVLARQPILTGFSQDDGSPLLEERRCPITMRHLLTHSSGAGYHFMDTRLKRYVEYTRRGNPAAIVDDLFDLPLLHQPGAGWTYGSGITWAGKVVEKLTGQSLGAYMDSNIFKPLGITRIAFFLRDGPCFPATHVSDMAIRDAATGALAPGPPGLPFLPPLEECFGGEGAYGSLTDYFKVLRSLLLDDEKLLRKETTRLMFEPQLPTQAARDGLRAAFEDPSWAVGDFSGPRELDSAYGGLLVVGDAHPFRMRGHLSWSGAANLYWFIDRGAGVCGLWGTQVLPPADTAVEQLIGAFEKHVYNMATEEDDAEGRSKSLADGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C833</accession>
    <name>A0A1C1C833_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">(R,R)-butanediol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bdhA</name>
        <name evidence="8" type="ORF">CLCR_05907</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C833"/>
    <dbReference type="STRING" id="86049.A0A1C1C833"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05907"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07356"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000721">
        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034079">
        <property type="term" value="P:butanediol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08233">
        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF23">
        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="12"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="360" mass="38250" checksum="CD9F33580BA819F6" modified="2016-11-02" version="1">MTDKMNAVRFHGNRDIRLDQIPIPAVKPGHVKLAPKFCGICGSDLHEYLGGPNIIPSKDPHPITGETIPLTLGHEFSGVVEEVGEGVTTVKAGDRVCVQPIIYDGSCRACKRGLVNCCDQNGFVGLSGWGGGLCEHIVVPESCVKPLPDNISLEVGALIEPLAVGWHAVDISPYKEGDSALVLGGGPIGLAVVQVLVGKKCKNIIVSEVSSRRREFATKFGAHHVIDPTQVDVVAEVEKLTGGEGADVGFDAAGVQPAVDTAFRAIKARGTLVNIAVWEKRATLAMNDIVFRERAYMGIATYSLGDFEAVIKAISTGAMKPEGMITKKIKLDKVAEEGFKALIEDKENQVKILVNVGAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8A2</accession>
    <name>A0A1C1C8A2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_06041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8A2"/>
    <dbReference type="STRING" id="86049.A0A1C1C8A2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06041"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07387"/>
    <dbReference type="eggNOG" id="ENOG502SKAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075:SF1">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="112"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="359" mass="39758" checksum="99573D174896C27B" modified="2016-11-02" version="1">MFKSFLVKPAVAVVRREGLGATRRALHLAPPFLLDSYIPRYHLLSAADAAKKRSAAYAHLRQCNLCPRLCNVNRYETTGHCLIGAETVKVSTIAPHFGEEPCLQGHNGSGSVFFSGCNLRCVFCQNHDIAHQKVGFDLTPEELAEWMVKLQDVGGVHNINFVTPEHVVPQVALSILHAREMGLNLPIVYNTSAFDSLESLKLMDGLVDIYLPDFKVWNNDTSKRLLKADAYADAARESITEMYRQVGDLCFTADGIAKKGVLVRHLVMPGKEDEGVQIMNWLAGALGKDVFVNIMEQYFPSAHVGKERRGAKGERGGEKRYSEINRPIKLDEVGVVQKAAKDAGLWRFAEAARHGGFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8B2</accession>
    <name>A0A1C1C8B2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8B2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06438"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT44701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="122" mass="13450" checksum="3A69810791ADCE63" modified="2016-11-02" version="1">MGKLESDDELFEENIHSQRADVELFGEDFESSFRLDASLRSVLELKGECRKTSTKQAGSESECEVEIGTTRPISVVMPCLPETVECSKLSPVQVSTRGLGCDHAPDQPHSCWCPAVENAKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8G4</accession>
    <name>A0A1C1C8G4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8G4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06291"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07505"/>
    <dbReference type="OrthoDB" id="10372313at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT44833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21311" checksum="4E4D5C279B13C91A" modified="2016-11-02" version="1">MSIVPSNLTFLSWGSTAGLVYSDPKTDVVAWLRYTGTELSPAPGGQPDTQQYAVQNAILVGKKTIVEAHPGKVAAFYHLDKIRLYYIQKTQPKDDAGEPNQIRQVCYTQSVADFKASKPSEWYRGPKGADTFDAKKFIAAPDSPLTVGFDQGFVRLYYKRPNENKLRVAFTTGSPSPNGNDVWKERVAAEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8S4</accession>
    <name>A0A1C1C8S4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8S4"/>
    <dbReference type="STRING" id="86049.A0A1C1C8S4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06025"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07593"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="348" mass="38214" checksum="EE0370023F745715" modified="2016-11-02" version="1">MAHPRVLLTGANGFIGSHILSLFLEKSIFVQAVVRSEAKAQKVRQDFPAFDKTQLDFSIVSDITAPGAFDQCIKDAQPLDAIIHAASPFDFSTAKTVADFIEPAVRGTTEILESAAKHAPGLKRLVITSSFAAIGNPSDLQGNGRVYSSDVWNPVTKEQAPTLNLRFGYWASKTFAEQAAWEFIKTHKPSFELVVLNPPLVYGPLRHSIDSMSDLNTSNAPVWKLMTSEKTAQVPEDTLHISVDVRDLAFAHYQAAFALGVGNRRYLVTPGSHRNQEICDILRGEFPELDQKIPLGQPGEHSLPEGFFKIDNRASQEILGVTYRPFAVTVADTARSLLEVEKKLSAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9L5</accession>
    <name>A0A1C1C9L5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">tif224</name>
        <name evidence="11" type="ORF">CLCR_05679</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9L5"/>
    <dbReference type="STRING" id="86049.A0A1C1C9L5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05679"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07840"/>
    <dbReference type="eggNOG" id="KOG1467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="512"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT45186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="603" mass="64243" checksum="5595369AAA7CC4BC" modified="2016-11-02" version="1">MADSNSNPAGGGTSLNPKAAAFSMPPAPGETGRSNGTPQAAESAVSNGNEEAKGSKKTKPRPDAAPRTTTEQNIAEAGAGVKLSGAALKRQKAAEKAARRAEKVAAKGEQAVEENQAQAQAQAQSQSATATSGSKGETQRRPSTSKRESETGSHHKRTPSGKGLPIRGGPQQQQQQQQQQQQQQQQQQPPQSAAVEREKRAEVKRVPIFAHLYPKEKKATLSGAGREIHPAVVSLGLQLRDHVICGGNARCVATLLAFKKVIQTYTTPPGVALSRHLLTHLNHQIAYLRNARPLSMSQGNSIRWLKNLISTQPVDTTDSDAKSTICQAVDLFIRERITLADEVIAREASGRIEDGDVILTYAKSSIVERTLLTAHHQGTQFKVIVVDSRPMFEGRNLARSLVRAGLKVQYTLLSGLADVLSYHAQGDAVTKCFLGASAMLGNGNLLSRAGSAMVAMMAKECSGKNNARVVPVVVLCETVKFTAKAALDSIIMNEVGDADALVEVEELNILSSTKPAPTPAEAGKGGKKQQGGQKDKDDEDAEDKNSSRGLEGWKDQPNLFLLNLMYDVTPAEFLDLVVCELGSLPPRAVPVVNGVHGDDQALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9V7</accession>
    <name>A0A1C1C9V7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9V7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05412"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07960"/>
    <dbReference type="eggNOG" id="ENOG502QQXP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5229017at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="987" mass="109228" checksum="A46C37B35ED0BF7A" modified="2016-11-02" version="1">MDITRRRNLTAAIPSPLLRNSNNFEDFGCFDEEECRFFLREVGERVVPVYPFSFGMEEVYSLILERYGYSGLPDATSVLQDLLESDGTAGGLGDDGDVWRSWRHSWRHRNDDALNPFIPKVGTFILQPPTLPHVRKIKALNFIRMSEESEREEQAREAVIAGKRKAFCEVTPERGRVMLAPTTTTVQQQHSEEGDLYRLPSTTYSHQRTRTLLSSSRGSPTSRQEQCQRPSTARESDKVHQSFGGSSQPELPEVDPLLFDANIDPSLLITFGMLSPSRPSGEAGLSPTLRGGHGEAVTFQPINSQGSPSSKIPGTVLSNSPLPRIQSSPFRVFTPETPRSHVRTDASIRSSRVVSEPLQVSVKEDKQGSVEHDKSFERLRKLSDGLRPFVRRPAGDNSERSKRIRATHRQVRILDGVILNPKVRKRLSSPPITAVEDEMPVEDKKKSGVRRSLTPVWQKRDSSRHSWMEIMRNFFRTEATACQTAKQSKRESSNLSQPAVRASTTPPSHHTNDNSQTTQRDQPSYLLGLDGTVDPRPFFFRTIAFRMSRMSRMDCNKPLPLSPPGIARSLSAHPGFPNAFQPRPSDPAILTRANTRADLKRNLQALTAHALKRKEIPDKHQFCPVYDELGDTFGDQTVDPAKPVQQPLSALTYSSVTNANPFVNQQNVPASPRQSQPPLSGITYSSIQNANPFFGAPDTPSSGFCPIPTSRQGNLDFSLPPPASKPHFSTISPQASTLNPAANVFTPFKNLMRKGSSSKGVNDNATTGGSPSKHHTRKISLGKLSNLLKNPFMSQVPTEEKIDQWMAGTNVPSIRPAAASPARPPVVSLDPAFQAYVLGQVEGILVKSTNGFLLHSGKMGRLDRGLVEQVAADWKEAGRAPVIDFFYDCQTQRQLVLRHAATVKFNNLDNDRFARALELWSALVAALSPRVLCLTDKVILGHVYALPEVLRMLRAPEATRVAARDLGRRVTAEVDSRKAAVANTAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA01</accession>
    <name>A0A1C1CA01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Homeoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_11197</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA01"/>
    <dbReference type="STRING" id="86049.A0A1C1CA01"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11197"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07996"/>
    <dbReference type="eggNOG" id="KOG0849">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="69"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="71"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT45363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="634" mass="69802" checksum="E24B91D41F052EC8" modified="2016-11-02" version="1">MDSPDIKHDPADTMSSDPNDFDIDDSVQSTPSPNASHPTQTTPATSSSSTQGPSSAPRRPPRKSTLTQQQRNQKRQRATQDQLVTLEMEFNKNPTPTAATRERIAQEINMTERSVQIWFQNSRRRAKIKMIAKKSLETGEDLDNIPESLRQLLAMQAMESGRPFPHQLLRPGGPVAQYGSGGMLMNGDPNAQGKVVIHHFTCRSLSIGSWRRVGQNAMDLVIFYSPDKACITYYINNDSAGYKIEFPFAFIKSIQLEPGDTNPTATGAPPRPGGLVIELTRPPNFFMDSSNSGGFYQCGDFTEDQQASQILVHHLGGHPKVLSGQLAKLVSLDSFQNRMNPFDIHAMPASAPVSPTMGIVRPASQPNAQFARPHPPHVGMFQEQFGVNHHLHPSRMHPGHKRQRSRSVPIAIDFSMLHGPMPTFHIQQPSPQLAPDHHNLYQPMPQHPVQNPLGPSLQIDTSAGYGMDFRQMPMSATATSPSEFASPGFFPANPAQPPMPASEFGTPQPFNGPFLSPSPMVDPNMIPTSMSPMPHMGHADPIIADQSPPLSALHRSASADMFSHHGMMDETLMLGEMYSKQNLNIPMPSPGIDENGMLMMHDMSEFHNAREHMDMPMTPFGTVDPHALQAGLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA95</accession>
    <name>A0A1C1CA95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA95"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05835"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08030"/>
    <dbReference type="eggNOG" id="ENOG502S7BG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5286775at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="488" mass="54371" checksum="2A6D8CBA02EB8B76" modified="2016-11-02" version="1">MAKSVLVSPFRYLANLVGSPKSSASTDSSHLDPSLRQDPSPSIKRKVDQDEQFARQPKRRAIRTGHDTPDPYEDDNDSHSASSPDLPFERTRIKAGLDRSLMPPPATPHGKMKDFPIQRISPSTRRDSQSWIRDDDSTSFVSTAVTRKKLDPVDNDLMEEARRHAAAITLPANSGIWSQTERELFFHLAYRGFEPLLPQNWMLDFDTLPISVFAHEDSLDPALIQNVRDNQFRAGHALRRLFEAGQDARDRSHVSPGVRRERVLEKSVKRYLYWALTDVGLRPRSKTQYIPVHVVAARRTGHSTLQTLEEVAAKLQKLSERHQRAQNVHPSVETRGMNSADADETRVADDDPSTPTLIGLVIISAVLVVVTLSPFAPLAPECTHGEIASPASSGPSTQGGTSFNPDRLRIIAELDFSQKDQDVWNALGVAIAAMEIRREALKVNRGFTNDDMSAMDWDGMSTPGSKFEDDMGEVSTLSRLQLDDDPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBM9</accession>
    <name>A0A1C1CBM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CYP-71</name>
        <name evidence="1" type="ORF">CLCR_00433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBM9"/>
    <dbReference type="STRING" id="86049.A0A1C1CBM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00433"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10088"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="459" mass="51745" checksum="13C55A308B6BBD79" modified="2016-11-02" version="1">MASFVTPALFPWLIAAFLVGYAVRTYYSYQKLSHFKGPPVAAVSSFWLAWQAVNARMPVAQKEALRRYGSPARIGPSLLVTDDPELLRHMSAPRSKWTRAAWYDGMKLDPRVNNIFSERDERRHAEMRSKMIGAYSGKEVETLESDIDENLQRLLTLIKQEYNGKPLDMALLASYFTLDVLSQIAFGDAFGFVQANEDLYDFNKLANEKFSIIELIVNHDFPRKLIQSQLMQKLMAPKGTDKFGQGRITGIAQKAVAERYRPNAKIKRDMLGHFIAKGLSQTQSEAESQLQIIAGSDSTAGALRITMMMLVGNPVAYGRLVADVDQAIVDGKISYPIVRYSEALEIEFLTACIWEGIRLYPPLFGLQSKLAPPEGETVNGVYYPPGTQVAFCCEGVGRRRDIFGEDADLYRPDRWLHPDPKLLRNFDWALADPVKGAISIAHGIWVQEKMMLVAWPRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBZ6</accession>
    <name>A0A1C1CBZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00499"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10022"/>
    <dbReference type="eggNOG" id="ENOG502RYGD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40257">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40257:SF1">
        <property type="entry name" value="DUF1330 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650699" evidence="1">
        <location>
            <begin position="17"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="277" mass="29646" checksum="9C8C632351C31FBC" modified="2016-11-02" version="1">MPLATIHLLALSPTTSLPSCLQALYNSVPRSKILITSKVIRWIITPTTIDAQRLLKPKSPWTLLLILLGTDPLPASLTSDVLDHWTSVAGIPSRLTADFARTNDGLLHPKPEAIPALTGSLDKPRVGTTSQTLELSPGLLDWMASFRKTRAGSSPLSMLNLLAFKEGKKPSYLKYGAAFAESIGKRRGGVAKLVGNIVVDASGKDGNGGNGAKWDEFALASYPSVLHFADMLAGEDYQGVNLTYRVPALEDTLILCTSEIEVEGILEAEGTGQKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCL6</accession>
    <name>A0A1C1CCL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ALG8</name>
        <name evidence="13" type="ORF">CLCR_01288</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the second glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(1)Man(9)GlcNAc(2)-PP-Dol to produce Glc(2)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCL6"/>
    <dbReference type="STRING" id="86049.A0A1C1CCL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01288"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09265"/>
    <dbReference type="eggNOG" id="KOG2576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1689333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT46255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="290" mass="32454" checksum="B73902142558D62A" modified="2016-11-02" version="1">MFQPQFINMLKLGTSIIGIFIAAFGPFAAWGQLDQLKSRLFPFARGLCHAYWAPNAWAIYSFLDRVLIVAAPYLGLSVDEKAVHSVTRGLVGDTSFAVLPDITAQQCFGLTLAFQMIALTKLWLSPSWESFVGALTLCGYASFLFGWHVHEKAILLVIIPFSLLSVKDRSYLASFRPLAVAGHVSLFPLLFTAAEFPIKVAYTISWLIIFLYTFDQLAPVPARRRVFLLDRFALLYIAIAVPLMAYCSLLHQAVFGHRYQFLPLMLISTYSAIGVLGSWLGFMVCYLSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCZ3</accession>
    <name>A0A1C1CCZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01154"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09200"/>
    <dbReference type="eggNOG" id="ENOG502T4SQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="524" mass="59217" checksum="88E0D4D4C0A2586B" modified="2016-11-02" version="1">MKVLFISCDGQGQARKTISDEGVTRCQHAAREYHKNAKLRRARNKAQPAHESRKRIKSVVTATGEPAVPELKFEQHSPTQILLGASRSDPFNTIGDAGVPLYVHEMLDHAISYHWSELCLSDGGGRNAARAEMMQSVMHSPTAWYTIIYAGATHNAYQYGGRGTTKQNEQLRLVYKTKAIRSLLECIQENGDSVSEEALLSMITLASHGTGESLKGYDSYKRQNLPFLSHLHDVEYYASMDIGMEHLTAVYAIVDQRGGLRTLRRKSLAIIIQILLAPTKCHINKRSHQPDVDAQDMLATRTTGFRTLISHGYTSLGDIIEVADNTSIFSADFDQLLRCYDLPKEQQPLHTPNIALVRYMRWCVLHDILTLPEHDIDDESLPEQVIYEICRHVLFAYAVFVVVPMPPRTTLHAKIAERLGCILTRAIKVGVHDQQPDLFHCAVAWGWMCAEKAVGYRKRDKLLGSFAMLLEFTRVPRKPESWPIVEEIMESFLWMEVYCEEPGRKFWASACAQVEEDYKGGESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDQ8</accession>
    <name>A0A1C1CDQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glucose-methanol-choline oxidoreductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDQ8"/>
    <dbReference type="STRING" id="86049.A0A1C1CDQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02064"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01365"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="136"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="291" mass="30576" checksum="2ABC4DB1E018DDA9" modified="2016-11-02" version="1">MAVVQQSASTSSIAINDSTLAAAEQQFLADGTGPWSAPSGITNAFQQLSNATLQAIGAQAVLDAGLVNQSHVEFLYESVFYPSNVALLPSSPGSGSGASCSWTAPPTTPNSPEAYYIPQSNLSYMSLTASPLVALSRGSVTLKSSSMSDAPNIDPNYYADATDRAVAINAFKDLRKLLAHPALAQYTVGAANGEVQPGWAHVPANASDDVIFQYIQANTIPNWHASGTCQMLPERDGGVVDARLRVYGVQGLRVADVSTVPRLPDVNLQGPVFMLAEKAALLIKEDYGLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDY4</accession>
    <name>A0A1C1CDY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDY4"/>
    <dbReference type="STRING" id="86049.A0A1C1CDY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02115"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01450"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650807" description="Carboxylesterase type B domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="30"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="192" mass="20309" checksum="E16D9CBD3F1F8333" modified="2016-11-02" version="1">MRFVHVSSAIVSLFASVLALPQASQSSNGAPTVTVESGVVQGVSTTISGAPRNVTKYLGVPFAAKPLRFAPPAAPQAWKTPFKATKYGPACIQEFAYPAHDITISWFNTPPPPAGESEDCLNVNIYAPATGKNKTVMVWFYGVAFGANSLAAYDGSYFAAFQDVVIVTVNYRTNVFGFPGSPELPARGNNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE17</accession>
    <name>A0A1C1CE17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_01837</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE17"/>
    <dbReference type="STRING" id="86049.A0A1C1CE17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01837"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01409"/>
    <dbReference type="eggNOG" id="ENOG502RZ22">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF66">
        <property type="entry name" value="OS04G0158400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="582"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="698"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="340"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="466"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="753" mass="82382" checksum="E370F167CC368D68" modified="2016-11-02" version="1">MFSVNANSSAHRSSSRESHTHIDITHIAPRSPSLGSQDDELHENGVHVSAGVSPQYSVIHPTQSQSQSGSSSHQGDFVHLQYPNELVEGDGSDSVSRVDHRERIQHYESRSNSGRREPARRQESLRAPARSRTRELQESSPTESGDSTEEFLRQDLESRRMPRPQSYYGHNGYTIHSGSSAHSYPYPPVPPHAGQVVALQPQAMAVPYPPPFPQGQPAPYPPHGAYHPGGFNPHHASSQVSAPYTSSPYGPPTIVNYGAPPPPPGSYFPGQYPTPFGPQQYPSQYMQYPQPMPSQLPYPYPFPPIASSPQPPASARTSAEKLEAKSDEDIVKRLQAMMKEEQAAKEADAAEKAAEKAAEKANLAASLAEQEARFREQALRQAEEKARQDALRAEEEKRIREQAMLQAAEKARAEAAAAAARAEEERRIREDAIRAAEEKARAAVAAEADRRAQEQRIREEARLEAIRAYEEQVRKAAEQAAREQQIRKEAAEAALRAAAEEAQAKAEKAAAEKKIADDAAAAAKTAAEQEAAAAAAALKEEAKAAKEAAEAKLKEAEEAAAKAKAEAEEAEKKAAAAAPPAKKAPVRFKDAIGRNYNFPWERCCKWRDMEGLINQAFAHIDNLAEHVMNGRYDLIGPDKEIIMPNYWESTVEPDMHITMMLWPIPEPKPVEEEPPPPPDVILDTDGILNLDGIDIMNPRKERKAAPKKKKPTGLAGWMLGGSRGSRSLKGDKKPDVAAKPQHGATDQGACVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEF6</accession>
    <name>A0A1C1CEF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEF6"/>
    <dbReference type="STRING" id="86049.A0A1C1CEF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01908"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01572"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650755" evidence="1">
        <location>
            <begin position="26"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="562" mass="59713" checksum="2A218760876C182D" modified="2016-11-02" version="1">MAAGFFRRIQGLLLVSLSLNTLVAAQACYNQSTAINGTAFPPLIEATTEDLVRGLESGLFTSVDLVEAYISRILEVNSTLHMVTQLNPDALSIAAQLDSQRARGNVLGPLHGIPILIKNNIATADAMDNTAGSYALAGAKVPRDSTIAAKLRKAGAIILGKTNLSQWANYRSYNTSNGWSAIAGQTVGAYFPGQDPSGSSSGSGVSSSLGLALAALGTETDGSILSPSDVNNLVGIKPTVGLTSRDLVVPISGHQDTIGPMARTVKDAAYVLAAIAGKSPYDNYTDAIPFDTIPDYVAACNFSALSGKRIGVPRNLIDLSYDSTAAPIVPAFGAALDVLRSAGAIIVDNTNFTGYDALNEGDYSTIVLEADFVSDLPKYLSQLSYNPNQVYDLEDVRNFTHMFALEDWPERDTLIWDSALELGYDNTSPEFWSNYTMNTYLAGPLGVTGALANYSLDALVLPTEFSPNFPALIGSPVITVPLGAFPADTEITPNGFNNLNATAPNLPFGISFMGPHFSEELLIGLAYAFEQRTLVRNTITPYIQPTVELVDVVTARSKRAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEM8</accession>
    <name>A0A1C1CEM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_02389</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEM8"/>
    <dbReference type="STRING" id="86049.A0A1C1CEM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02389"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02486"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03002">
        <property type="entry name" value="PDI_a_MPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057305">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650768" description="protein disulfide-isomerase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT46932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="514" mass="54631" checksum="209A246EE1C8C0F8" modified="2016-11-02" version="1">MKLPTSLFLTLGCVLHVDALYSKSSPVLQVNAKTYDSLIAQSNHTSIVEFYAPWCGHCKNLQPAYEKAAKSLAGLAKVAAVDCDDEANKAFCGQMGVQGFPTLKIVRPGSKPGRPAVEDYMGPRSAKGIVEAVKDKIPNHVKKLQGDALATWLEDKAIPAKAIVFTDKGTTSPLVKSLAIDFLGTIAFAQVRDKATAETHGVSKFPTVHLIPSAGATPIPYDGEINRESLVSFFSQVAPPNPDPAPKAKAAKSSSRKPKSKPASSASAAFSRASEAHKSSDFEEHLAGSSTIVLDDTPPTESPLPIVDTEEKPMVIPHVVAPIPTLSTAAEVEAACLLPKSGNCILILLPAGVTPSQATTSALSGFAEISDKYNKRKAVVIPMYAVPADNQAATLIRNDLGLGSDEKMEIIATNMKRGWWRHYQADSYDILDLESFIDAIKLGEGSKSTLPAGFVAEASEPDVVESTETVDSSEHIAEPEPEPEDTPTAETTSEISSEAEPEPAETPVAEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEP7</accession>
    <name>A0A1C1CEP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02384</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEP7"/>
    <dbReference type="STRING" id="86049.A0A1C1CEP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02384"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02466"/>
    <dbReference type="eggNOG" id="ENOG502RBAK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7295497at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF19">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="415"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="461"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="539" mass="60476" checksum="4A6F6863E2800B99" modified="2016-11-02" version="1">MSSPTPTPSTQPPMLAQAALVGGWNDGYNSPGGYLSALPKNFQDQRFHKRDSSGSSVTSVGPPSPLNHNTIYPHIVATSDSSFPPAYDFDYSQTPHTAKSETAMMYPTNFGPVDMRRIQSTGADERASYALSAPQSVSTMSHNSPATPHTAYEPEYDVKREYGETKSAVDDMIDYLQFESGYTNAYQQSLQDVFPDQHFANPMAYSQAPQQNMQRLTVNSHRQNMMAERLQAAQQDHLRTNSPTSNPRDKSPFRQNSPYSMPAPAQRPQPTLQKQRTSISPKELMLDEHDIDDHATPLFAQDQSQSMFANRRNPSNLSSFYTAANEQSMQMPQQYPFVSQPSRQSAQPGMQDVTPDFPAHMISMESTADEASEPSGSQQSMQKPRLQPQVQPAAPQHQQTPQQRPVDTSSDSGTYSCTYHGCHLRFDTPAKLQKHKREGHRQVSPSASPNLALRNSQAGPHRCDRINPSTGKPCNSIFSRPYDLTRHEDTIHNNRKQKVRCHLCTEEKTFSRNDALTRHMRVVHPDVDWVGKQKRKNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEX4</accession>
    <name>A0A1C1CEX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">KLP1</name>
        <name evidence="15" type="ORF">CLCR_02250</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Its motor activity is directed toward the microtubule's plus end.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEX4"/>
    <dbReference type="STRING" id="86049.A0A1C1CEX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02250"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02397"/>
    <dbReference type="eggNOG" id="KOG0240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000031">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF36">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="13"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="386"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="901"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="674"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="764"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="94"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT47021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="945" mass="105001" checksum="BA2E64E1451A909B" modified="2016-11-02" version="1">MATSSTREGGGNNIKVVARFRPQNKVENANGGQPIVQFTGDDTVQLQSSETNAPFTFDRVFDMSSQQADIFDFSIRSTVEDVMNGYNGTVFAYGQTGAGKSYTMMGDMDDPDKKGIIPRITEQIFDAILVHGSAQIEYTVGISYLEIYMERIRDLLNPAFDNLPINEGPKGPYVKGLREIYVNTVEEVYTAMHLGQRSRVTASTNMNLESSRSHSIFLVTINQKDVNTGSQKSGMLYLVDLAGSEKVGKTGASGQTLEEAKKINKSLSALGMVINALTDGKSTHVPYRDSKLTRILQESLGGNSRTTLIINCSPSSYNDAETVSTLRFGMRAKTIKNKAKINAELSPAELKRHLKIAQNQAMTFEKYIASLDAEVQMWRKGETVPKEKWVPPLSGAGQKTEARARPDTPSRAPSDLLRSDTPSRPDSRAGERSSTPSIILEKDEREEFLRRENELQDQLTEKETQAANAERSLQEAREELKSYKEGAMRTAKENEIMADKLNKTQLELQKLSYQGKEDAITMEGLKDANSELETELISVKQQLLELKMSARETTAVLDEKDRKKKEKMAKMMAGFDLGDNAFSENENRMREMLDQVDALHAASLNGESVPSHVLEDLRAKLLDSQTLVRQAEKSLSERAEDDREDRTIALEEKLAAVQQDYEDLLSGKLGADDVESVKGRLEQLYSDRRDTQNELVHDLRDQLTHKSQEIEKLQKTITDLQSRVGPNGAVANGISGKTLQQQISDFESMKKNLMRDLQNRCERVVELEISLDETREQYNNVLRSSNNRQQQKKMAFLERNLEQLTVVQRQLVDQNTSLKKEVAIAERKLIARNERILSLESLLADSQDKLTAANHRFEAQLAAVRERLEAAKVSSRNMATGGAGATGGFNSLMNAGARIAKPLRGGGGAPPHTESANGGPGLPIISNLSASDGGNKRGSWFFNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFA4</accession>
    <name>A0A1C1CFA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-coumarate--CoA ligase-like 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">4CLL9</name>
        <name evidence="5" type="ORF">CLCR_02371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFA4"/>
    <dbReference type="STRING" id="86049.A0A1C1CFA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02371"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02284"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="28"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="459"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT47146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="562" mass="61723" checksum="9AC6BE91799A0166" modified="2016-11-02" version="1">MPSRVYRSSYPPVELVDSDLLPYLFSNPNGTPEDKPIFVDAVTGNTRTYGEIKRRTRSLARGLRDLGLKPKDIVAFFSPNSIDYAIVCYGILGCGATVSPASAANTPMELQAQLETSGAKYLISHSTLLATAEEAIKFDPSIQIIQADGAWDKRGKPTAEKLADDCLPSPLVSVKPSEADDRLALMCFSSGTTGRAKGVMTTHKNLVSNIIQWMAQMPIETTGKLTTVTFLPFSHIYGLMCFICINTYVGNTAVVLARFDLDAFLSSCQKYRPEVVSVVPPVMLLLAKHPLVEKYDLSSLKRIMSAAAPLSVELREAVEARFKRLYGTDLLGLQAWGMTETSPLGAHCPPDRPDKRHTVGNITPSMEYRVVDPETLQDTGYEADGSAIPGELWCRGPNVTKGYYRNEEASKNSYATDEEGRLWFRTGDIGSIDADGFLTILDRIKEMFKYKGLQVIPTELEGKLLEHPDVEDSCVVPQWVEEQATHVPVGFVVLNQKAKAKGEKAVVEGIHSWLNPRVANHKKLRGGIYVIDAIPKSASGKILRRELAAKLKAMPVKSGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFE2</accession>
    <name>A0A1C1CFE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02624"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02186"/>
    <dbReference type="OrthoDB" id="4117504at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="214" mass="23751" checksum="8768608669D10421" modified="2016-11-02" version="1">MSTASSAPPPPTIVINTPGAPTSTVSAPRTGPPKEQPRQRAQKPALVKQCYLCDEQNPGDFSPTTKFLETCLLCSRHFCPIHKSVNWDQVCNINHADYYRECLEKARQELVSQGRGDDSNRRSLAEMLINEGIYPSLGEREKAIFMTSPVSESKYTPISRYVPKVERLTCCANPAKMQELANYRSLDAAMQGTSTKPKNQLIEEKDFVGADIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFF0</accession>
    <name>A0A1C1CFF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_02622</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFF0"/>
    <dbReference type="STRING" id="86049.A0A1C1CFF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02622"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02232"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="179" mass="20131" checksum="B2F59C47A37C988E" modified="2016-11-02" version="1">MPVAFYWDKNIEGGHCIDMMAFWFSFSGFNIVTDVAVWVLPMPVLWKLQLPRKQKISLVAVFALGGFNSTDLTYDNVGAATWSAAELNVGIMCACIPALRPMISMIFPRLLATTRRDHGSNPYPPRAPYMRDESAVELSQNVKAQSEISRDDSASYDNGHEPNSIRVKNEWSISERERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFH8</accession>
    <name>A0A1C1CFH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ammonium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_02617</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFH8"/>
    <dbReference type="STRING" id="86049.A0A1C1CFH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02617"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT47207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="192" mass="20817" checksum="AC80CDB94421CEF3" modified="2016-11-02" version="1">MMDLMFFTKSAVIGAIQRIITGLVDNTPAVGFVAGWGAIIIGLCWGIIPWISTNILGKQKCFLEPSGNIVGDSQTHLVGGIVGGFLTGLFATNEGVVAFAPTPVGGAIDENGRQLWVQIVGFRFIISWETVLDQRDLPVHPLFHGELAYAFFDDGRHDSDAHYGKSSRDSEKRAGVLRALMLQETSAANIQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFJ6</accession>
    <name>A0A1C1CFJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_02446</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFJ6"/>
    <dbReference type="STRING" id="86049.A0A1C1CFJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02446"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02140"/>
    <dbReference type="eggNOG" id="KOG1499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060567">
        <property type="term" value="P:negative regulation of termination of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="7">
        <location>
            <begin position="76"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="8">
        <location>
            <begin position="187"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="366" mass="41869" checksum="480384A4547B3E19" modified="2016-11-02" version="1">MTTANGAKPSVADMANMSTEERMAGMEHSEVRYFTSYEWPADRYSSHHGIHEEMLKDEVRTRSYRDAIYQNQHIFKDKVVLDVGCGTGILSMFAARAGAKHVIGVDMSSIINKAKLIVEANGLTKKITLLQGKMEEVELPAQHLNDGKVDIIISEWMGYFLLYESMLDTVLYARDKYLRPAGLIFPDKATIYMAGIEDGEYKEDKIGFWDNVYGFNYSPMKESALSEPLVDTVELKALVTDPCPVFTIDLNTVTTSQLAFSEPFQLRVQRNDFIHALIAWFDIDFTACHKPIRFSTGPHTKYTHWKQTVFYLREVLTVEEGETVRGFLSNKPNSKNRRDLDIKIDYELETEDRTRAARGTCEYRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFS9</accession>
    <name>A0A1C1CFS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_03687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFS9"/>
    <dbReference type="STRING" id="86049.A0A1C1CFS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03687"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01981"/>
    <dbReference type="eggNOG" id="KOG3313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT47395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="222" mass="25434" checksum="99DB13453763829E" modified="2016-11-02" version="1">MDTTTTNPRGIPTFPFMSNVTDYVKSIEDVEPTLQRFQEMVSKYTFMQQNLERRAIGLKEKLPEMKRTLQVVKFLKKKRKDLAEKKEKDGVEELSLDEDDDLLGEKKPGGDELETTFSLQDTLYAKAIIKPAHIDEVYLWLGANVMVAYPLDEAEELLQAKWDKAKESLTACDEDLEFLRVQITTLEVAIARVHNWDVGEKRKLRAQGRLPESVGGKGKEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHT8</accession>
    <name>A0A1C1CHT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_11288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Noorani M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11288"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00485"/>
    <dbReference type="OrthoDB" id="3540210at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="656" mass="71445" checksum="0BC6D2A7F856448D" modified="2016-11-02" version="1">MSHVYTGIWNENLPERTRHHLTVSDSTAFAILTVVALMIEFAVMSCWFEHYPLLRRLLPQRLQDLDKLKCADGVAPSVVLVSLVRFFWRERHVGDDRWRCILLGMWSGMFVVAAMGIPIAAAWGLTYATEETPPVKASGSTCNVVRGISRSQTTLRNINLTLAASEYFQSCYLQHTPVSCQSNLAQDSLTWVDSDTSCPFAAEICLETGNATIVRLETPLITMDELGINTPTKLRLKKALTCSVIRTESFRGPPASDVEGVSSTLVFGSNSAFEYDVRNLSMVAPGYRLTTLAENILEPDSLDARLRIADGFVTVVLLQAPDVYFAEPMHDLMFAAHQENNFPSGLRWSADNLINAAACVDQYLVCNNDTGVCGSWSSPEEEEAEEEAAFSLLPLGLLNSDADQQAWDMVRYVLTSTSVHYTIYGRGSSALLAQRSLFSQNQESLGSRPWRDEVNGWFGVSLAKLQLSIHAIARPTPFLPLDAFQAFPPDAGTLQLCKMVKSREANYTNIHWPGFIATVVVCGLIGLIRVSHNVFNTWKIDLRPSLQQNSAPLLVNSPPSSGHGSPPIMLIPVISQQQQQQQQQQQQQQGAPPIPITQAGSPPPPTPPIPALTSPPPSPSSPTPGSPMAPSPSPSPSPPVSPSPTPAAPSSPVGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI69</accession>
    <name>A0A1C1CI69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_04016</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI69"/>
    <dbReference type="STRING" id="86049.A0A1C1CI69"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04016"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08367"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="555" mass="62481" checksum="3E96915BB6C151BC" modified="2016-11-02" version="1">MALPSFPLLAFSSLAVLCLYRFIIHPLLFHPLKHIPSAHWSIPIFGDLWITYQRYMERNNAVTYAAHLKHGTVVRMGANELSVNCVENGIKTIYAGGWEKHAWYPQRFGSYGVVNMFSTIHHGPHSQKKRTMANVYSKTYIASSRQVAANSHALFSTRILPLLQDLSQSGEPTDVHDLHNAIAMDFMSAYQFGLSAGTNFTQDLAQRRHILHQYHCRRDYEFFSAEAPWLKKLTRTLGLQVVPYFVDQANVLLEDWNAGMCRAADKYLAGSDNNTLANPGDEPVVYKQFKTGITKLREKDPNAGKAVGEVTLPTTRHENLHTNGSDTTTAEIYSEMLDQIGAGHETSAIALTYLSWEMSKNPSLQDQLRQEVLGLTPPIKWPLPAGSDPAKDFKLPDPKQIDALPLLHAIVMETLRLHAPIPGIEPRISPNVPGGNTLGPYSNIPGGVRVSAMPYTLHRNPVVFPNPETFTPTRWLPSHTSEEQLKEMHRWFWAFGSGGRMCIGSHLATQEIKLLVASIYSNWRTEIVDDDGIEEVDAYTTKPRRNRLDLRFRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIC9</accession>
    <name>A0A1C1CIC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sucrase/ferredoxin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIC9"/>
    <dbReference type="STRING" id="86049.A0A1C1CIC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04130"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08373"/>
    <dbReference type="eggNOG" id="ENOG502QT0V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF14">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="434" mass="47816" checksum="2DB128A5937ACA37" modified="2016-11-02" version="1">MPSLKDKSFPTSRTPQRSKMSLLRRVTTFLTPTQSSANLHAGFSTATTEADLFPPTDPAIDGEQCLHDCSSCTVHYPAKFSIDEDDRLFGHVKDFNVHLLVGTGKTDWVRDVTDEKHSVMQAVGKVGLEMSGKRGKVMLSASNFPSGEECHGPGEEEGTADVMLLPSWKLIEKVPPSQAGALMKEVVERSSTNDTPVGGRRLELNGTPNGHTAAPTTTEQEQVQQDAEQRQEAGQEAEKEQEETPDLSSLHIGGGTAQPPPQGTSEQELQESQPESSLDPAPIPPSISTSFKIRPIPHSYLILMCSQKTRDARCGQSAPLLRKEFERILRPLGLYRDVHDDRPGGVGIYFISHVGGHKYSANVMIYRRQGQKRDGKDADGQKLEDEAVQLIWLARVRPEDCENIVRYTILQGKVVKPKSQLRGGFDREKGVASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIH0</accession>
    <name>A0A1C1CIH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heterogeneous nuclear ribonucleoprotein D0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_04111</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIH0"/>
    <dbReference type="STRING" id="86049.A0A1C1CIH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04111"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08467"/>
    <dbReference type="eggNOG" id="KOG4205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12330">
        <property type="entry name" value="RRM2_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="92"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT48323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="456" mass="49955" checksum="46A9A2DAC45FC266" modified="2016-11-02" version="1">MRDSATGRSRGFGFLTFKDPKTVNTVMVKEHFLDGKIVRATHFDESRERQDTLGSISRIHLHSLKRKHGDLLSGTQIDPKRAIPRDEQEKTAKIFVGGVSQDATEEDFEGFFAQFGRVIDATLMMDKDTGRPRGFGFVTFDSDAAVEKCLQFYPLEILGKPIEVKRAQPRGKMGEDEDFGRVRGRGKFGREDRFGSNDNNQPAQAAQNQTPNMMGGNSGMTPQMMAQYWQRMQQYFSMMQQQMAANMMGGMGGMGNMGMNPQQMQMMQMMQQQQKMQGGNSPNAQNAGMGNMQGMNPQMMQQMMNMQQGGMNGMNMGGGRPPMGPASMGGGQRQLSAQEQLAFEQQKYEQQHVRRQGGFPHGPRGGGFQGQHGQQQHGSGPQSWEGMYDDVPQPEGNAGGRGSAGPVRHNTPKPPKGPGGPAAPSAPANAPTGPKNPGNKPGGGFRGRGRYHPYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIS1</accession>
    <name>A0A1C1CIS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIS1"/>
    <dbReference type="STRING" id="86049.A0A1C1CIS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04434"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08552"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="115" mass="13174" checksum="DB5D7A1C4C42469B" modified="2016-11-02" version="1">MGEQAVNDDEPEEPAVPQGSITKVKSTHWETEGPVDAVDTAENEETARFAFLVRKLISYDSRKKYDIHSIIGQSPWLKKALGVILEGYPQYHHEPRPPRICRAFPSIRAWWNSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIT4</accession>
    <name>A0A1C1CIT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative electron transport oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIT4"/>
    <dbReference type="STRING" id="86049.A0A1C1CIT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04156"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08520"/>
    <dbReference type="eggNOG" id="ENOG502QQPX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="369" mass="41257" checksum="FE4A8781F4394BA0" modified="2016-11-02" version="1">MAGPVRQPIDLASLERYIDNNVPAIKTPLGLKQFGFGQSNPTYQITDAQGVKYVMRKKPPGSLLSRTAHRVDREYQIIHALGQTDVPVPKVYCLCEDNDVIGTPFYIMEFLDGRMVTENHFPGWSPEDRTEAWHDALRTLAKFHRVNIQAVGLSDFGRHGGFYDRQSKTFSTLQRAQAEAVDVDTKKAVGEIPHFDEMVQFFKQKSTQPKDRVTLIHGDYKIDNLVFHKTEPRVIGILDWEMATIGHPLSDLVNLTAPWSWVGRDIGGAKNDTEAFRDGVTPGLPTLKQAVQWYAEASGYNPELELAWGNAFGGFRGAVIMQGIAARYARRQASGVTAKNYASQMPLYADWAFGLVQKLIQTSDGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ10</accession>
    <name>A0A1C1CJ10_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_03924</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ10"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ10"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03924"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08629"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000319">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT48505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="545" mass="60168" checksum="0A214F3C820C001E" modified="2016-11-02" version="1">MAAYNLPVDSVPGTVHLVDIEHTMHTRHAGSGDKDIVLVPTPSNDPDDPLNWSPKRKLMNTVSVNIYTLVVGIANSVVYSVLVPLSEASGVSISTLNQGTGYLFLLAGWGLLFWQPFALRYGKRLTYILSICGTIGCTMWGPYARSNGEWIAKNILGGFFAAPIEALPEVSVTDIYFHHQRGTYMGLYAFFLAGSNYFAPVICGFIADRQGWKWVFYWPTIFLVVGLGWCFFFLEESNYKRATVGIVETTSGSQSPTSVTMAEKSGEKLPEVTNEPASVESGTITYGTSKTYLQRLSLWQPSKGENMLPRAIRSLKYLGWPVIFYAGFSYGSYLIWFNVLNATASIILGGSPYNFKASMVGLSYLSTCIGVCVGSYFTGRFSDWLTIRLARRNNGIMEPEQRLWPFAACIIVVPASLILWGVGAAHQVHWFGLVFAMGTLAGSTVFGITLSVNYLIDTYHEISGDAMTTIILVRNTMSFAIGYGITPWLDNLGLQDCFISAAFIGMAASSVFLIMIFYGKKFRERSRVKYWNLVAELMAKGDASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ62</accession>
    <name>A0A1C1CJ62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ62"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03834"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10296"/>
    <dbReference type="OrthoDB" id="4155655at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1031" mass="116355" checksum="0F36758F33B61DD3" modified="2016-11-02" version="1">MNFNAGAPSGTPAEEHANHTAPVEVTPAGEAQASEDTNDQDHDDHEHGDHDDNDDGRDSDNPSEFGNHSDLSNDSDIDYVYNFHEEPETEPFAQPDNDGAGSGDLFTQANDDHATIHCEIAVLARGSRIVTDHHPATVYVRQRTGEDHGSRANGDTAPVESEKRRPCPTTARSVTDGFAAIVDSYVLAGPSEDVPANWGRDSLFRGSFQVLERSNDDIPVSEYGPIPNYQLFQIDSEDGLRSGLFDDHLKTRFLGFPDRPFVLHACLANNDTGEIFAHYSPDWNDCAQVVRINSPCFNRLFLQQRVLTIGDRYVALTLPAKYSFIYDGRNIHLVIREETLEQRVRKHASDRFMAVNRNSIPLSTAFAVWGLRFGVLPLACRNEIETVWRSMAYLADELYRRSTLGVPTALLDRQGLEILAVRLHRRRIDYHGRIMYRSSGPSGVHLEGRLVSVELIDEPLRDMRIRTVIEVTSDVTRFHLICLRHSADEFRRFGWYFSNRGDDPSGTYYGDGIDPLREWVPGKIIYQQRTSQGPLTFVVADDNTVNVHVDEKRLHSLLWSHHSSYPWPVRRYWPLTSLVSLFRQSVTHPECDQQELSTLVHRIFQLEVDRLALLQARDDEQVQQVQFVHYQFAVEMFRRSIMHEKTTIKTRTAVPRPSHAECAGTLYNVVPRLNHGVFSLECYFLYWSQAHQTTFGLMIEALEWRHLDPFVDFEAVEISMEGEEVPPYWDPRCEHLFNDVWQRVPLPTPTAPCPPPSSSVPFHIPACRMGALLRPLARALEANCFPAKADNVASVVQAHYNSFCASTGYAASTPLILQILAQFTAWHQTQFIDSSRRRRLDLYNNACAAREAVAWDDIRRQREVLVESSFEPCDVLLLLLLEVVVGWIFVQHDKHHMLPSPANHITWTYTLSPTMDEQVLSNLVLVLQTFTTVFECEHVVEKVVPVIVELDIDPASGSHTDEWYLYWRRVREERVDRLPGSTSTASPAEVAATVTVSETAATASSASVEAFAVLAAPPSAAPSAAPPLLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJB5</accession>
    <name>A0A1C1CJB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04351"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="186" mass="20725" checksum="EC136575D6F67CC9" modified="2016-11-02" version="1">MNMKVVKCKLIDAGYYVCDDVTVIMSAGGSTDKDFKKMCSGRRTGQTTWHYCENNTTHDNPGMMTNDPMMRAQYGLDLVFSVHALFVEEGYEVHRPQNAPERAMVLLLVLVLVLDRAEDGDIEVYIASNSQQQGKNNGDLNEHYRCDGGGGDDGDKLRGCAECILFSLRLQHVCISPLPGWLVFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJE6</accession>
    <name>A0A1C1CJE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">YME1</name>
        <name evidence="16" type="ORF">CLCR_03858</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJE6"/>
    <dbReference type="STRING" id="86049.A0A1C1CJE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03858"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10263"/>
    <dbReference type="eggNOG" id="KOG0734">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048438">
        <property type="entry name" value="Yme1-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21232">
        <property type="entry name" value="Yme1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="380"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="785"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="832"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT48587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="844" mass="91955" checksum="7C4F61A3BAA7E2D6" modified="2016-11-02" version="1">MALQSPLAQLPTLRKYRLARLRPESDVRQIHSASQRISRPSVRDQTLRWSNGSNALQAASNVVLPDFVASLPTETRVPMISPSTSRCLSSTVASHLNPLSNMRSAFSTSAPRTALRATASGNTFTPSRTQPSVASLLFGPPRRGGHSALKQQFRQFSATSSRSNQNMLAHAERTANNNPTSATAQNAFYSALLRANMPKLVIERYQSGRYATNPAADASYLKALQMTGSLPAPGAASPNVSAGQGGNLSPDKLRAVGQAVAGQNYGGQVVMPSNKSGTGAKEAPLYVVVEESWGATILKWVKTILWVSLAGYFLLVVLTMVVEMTGSFRTRVGQNNEVQPQHQTVRFSDVHGCDEAKEELQELVEFLKNPEKFNQLGGKLPKGVLLVGPPGTGKTMLARAVAGEAGVPVFYMSGSEFDELYVGVGAKRVRDLFTQARNKAPAIIFIDELDAVGGKRNARDPAYAKQTLNQLLTELDGFSPSTGVILIAATNYPESLDKALVRPGRFDRTVNVPLPDVRGRVQILKHHMRNMPIAADVDATNLARATSGMSGADLENLCNQAAVNASRLKYKKVTAQNFEWAKDKIMMGAENKSRVIREKDKIQTAYHEAGHTLVNLFTPASNQLYKVTIIPRGRALGITHFLPEMDAVSMAYDQFIAQIDVSMGGRAAEELIYGPNKVTSGIAHDVQSATQTAFYLVTQCGYSSKLGNVDLASDYDKLSSETKMEIEREVREIVEGGRQRADRIVKEKRKELEALKDALLEFETLDREEIMKVLRGEKLQKLEVELREDEERDNNDGGNKTPPKKEKETGPKGSLGIKLPDVLLPPGTGGRGGEKEGVSRVSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJK7</accession>
    <name>A0A1C1CJK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_04556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJK7"/>
    <dbReference type="STRING" id="86049.A0A1C1CJK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04556"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03199"/>
    <dbReference type="eggNOG" id="ENOG502QRAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13311">
        <property type="entry name" value="PH_Slm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043453">
        <property type="entry name" value="Slm1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF16">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-BINDING PROTEIN SLM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="428"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="603"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="707"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="748"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="806"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="812"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="913" mass="99290" checksum="0D9CDEF0CCC16B70" modified="2016-11-02" version="1">MSSRPVTPVSPIQSARPDPSIHSARPTSARISSRPISYVGTQHTQPIDTGSQLNHSQAGLQDPSALAQAADLHDEVVNQNQESLELPRTNSHMSGSQTLLPSRGGTLKKKASLHKSASIKRTASKRSSYAGSVRSLQLGEKEKYEETPETNSVFYCPVPTTGNPTELLAIRFQAWRKVLKDLINYFRELHKTYETRAKALMSTSNVINNTTIPPNFLSQGGVGDAAYILRDFHKQGLNEANKARDLENEVIIQLTGLRSDLQQKIKEIKSLSGDFKNSVDKEKEATKRAVQSLQEALGSVDHDAASTSGKGDPFLVKLALDKQIERQIDEENYLHRAYLNLEASGRELESIVVGEIQKAYNVLAGILRREADENYDTAEKLKEGPLAMAKDHEWDEFTTNNSQMVDPRIPIRQVSHIVYPGKDHPAAIEVRSGMLERKSKYLKNYTPGWYVLSPTHLHEFKSADRIAFQAPVMSLYLPEQKLGSHSELDSSSHKFMLKGRQTGSMHRGHAWVFRAESHDTMLAWFNDIKELTEKRGEERNEFVRRTHARSFSGNSLKPASIISSEGGLEDDEADRVAFSGEQSVRGNSIAPPDQVAVAGLGGLGVGAASHDNEDNRSEAGWRPPQQRPAPGGRFPSDLNVQRGLQAPLSPSSGESSDRDRDVIAAAGGLPGSGVPFANTMEKHTDLQPEAHQPAAPAPQLNAANQYTQGHHPNIFPAHPTAPPHDGASEYGEWMAPIGAGGGAAAGAALAASTIHRHKQQQEQDQRDRDRTPTAAQRLDGETAIPQYGESSAPIPAVTAAPIDAPTEPRAMSESTTAPSSAVANTISSGTDAGTLSTVPTSTGYTAPNGSLFDANGVFVGPREAKTAPTEYTLRPAQRSHSHTTISHLHVPGEFPTTLPLNEDSRVYRDVVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK74</accession>
    <name>A0A1C1CK74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK74"/>
    <dbReference type="STRING" id="86049.A0A1C1CK74"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05251"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02984"/>
    <dbReference type="eggNOG" id="ENOG502RNR7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5357531at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="132" mass="14817" checksum="461F1D4D98647CEE" modified="2016-11-02" version="1">MLASRSAKPKLALSISTAQTTRPSLSLKSPLTPLRSPLKSPISPSPISPTARNTRLNQRGYSTMQQPTYAYVNSSSSRSILKKSSPTKPSTQRRQLSFSESPVVYSVTPIEEEDYYGSHVKMSRDERRWSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKB2</accession>
    <name>A0A1C1CKB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05269"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="114" mass="12311" checksum="CCD7CDA67AD6D0B1" modified="2016-11-02" version="1">MQFVVLGMSMSPSGSPLTLTDLSPSRLHYETGNPLKSWRLEAGGGATYSYITRMARPVLGNGLGDEGSCAIDDLLQEATILRPASTFPHNSSKMKLYQARAGRPRPGPALQYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKK3</accession>
    <name>A0A1C1CKK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKK3"/>
    <dbReference type="STRING" id="86049.A0A1C1CKK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05153"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="193" mass="22525" checksum="184F995629934CB3" modified="2016-11-02" version="1">MSLNIVKPWTFKRLYAAGKCEDVGFIEMEWMEGDTLENVWNELTNEEKLSYARQLREVILDLWIKAGYRSPSQSEPGRPISDRGSLQRILAEQHHIHHSDHLSESAGSLFTATDHKIVFTHGDLSPINIIVREGRVVGIVDWEYAGWYPEHWEFVQFFRAMYADYRNFADVIFDKIYSTELVTDHLLGLLTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL52</accession>
    <name>A0A1C1CL52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ubiquitination network signaling protein acrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">acrB</name>
        <name evidence="4" type="ORF">CLCR_04560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL52"/>
    <dbReference type="STRING" id="86049.A0A1C1CL52"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04560"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02702"/>
    <dbReference type="eggNOG" id="ENOG502QSPS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4158994at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="858"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="738"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="866"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="905"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="943" mass="101791" checksum="310C47F504336D13" modified="2016-11-02" version="1">MPRHPAAKKHQHNNRHENGLVGPGKRVTKQKSNGHLNGTAKGPVPSEPVPQPSPSENSVSAAGSERGSAAASDTQQDSSKPALNLQPVVGDPDSSAAKEKDIKLDANGSSMLHQRRGDMVVSKSKAQDISVLHLASTILRSRPATDTVSLLIVLLALPSVILTIVQALFASLTLMPGGGAGTPTSLLSLLDIFQGSAGVPNFSTIGIVDTIIFGLWICLWGWAQNFALDLAQIQIAITLGNGSSGKNSRVNTFCVAGVLLLHLARSRDVRRFLYSNLVPVDLLSQTGLSEYLKYLPTDHDFGDSPGPPSYIRSLFAIHIIAQGGMASFRRYISSYSTGPAKSKRIDTEASAGSISDASALDGSTPAGVSSSVDYQPPPTPGFKDGKDNKSISAKKRRRQANHVRSKQPFWAALASTKVHVLREVEHNKALPTVAKQEGSPFEATHHDLVSITNVEPSSIMFEATYTYESAQSQDSSRKTDCRPFYVRINGAKWHAVSLDPPVTPSKPDGTARWTGTISGLAPNCTYTCTFIGCTGDEDFASIMVKTPMISDKDLPPSMAPVSGRQPTAPSSPTTTLKNSIATGEAKLSEARNRLTKVKRQHRSTQAKVEKEVESFTARLKIASDDSKQRQKLWQAERTRQQTEDANLELGAALENLVSTPEHDHDDYAAAKATHDEQQKLLSESNEALAKARAAANDDTTCVNQELSTIVARKERLSGRNSKLTEQHDRITHANVEGLNEKERKAAESLARSAEQQKRESELNQEILNLEREVRGAKMRWESNARELDILEKQEMAHRQMMLSNSGPLTPEGELPGTRSLPQHARPYAFGSFQAFPNSPVIPEVQGSPFAAYAKTLPTVDQRRPRSNTNQSAGGISNFSADFEDADPIPPMPTTAEYDMAGRKGSGSSRGKNNGSPAGIIGGTLRSPQRGSYSPGHVPGSTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMC8</accession>
    <name>A0A1C1CMC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Splicing factor U2AF 23 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_07612</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMC8"/>
    <dbReference type="STRING" id="86049.A0A1C1CMC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07612"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09910"/>
    <dbReference type="eggNOG" id="KOG2202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000066">
        <property type="entry name" value="Splicing factor u2af 23 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="44"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT49664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="209" mass="24337" checksum="8EB2FC144033B498" modified="2016-11-02" version="1">MANYLASIFGTEQDKVNCSFYYKIGACRHGDRCSRKHVKPSYSQTILLPNLYQNPAYDPKNKMNASQLQNHFDAFYEDFWCEMCKYGELEEVVVCDNNNDHLIGNVYARFKYEDSAQAACDALNSRWYAARPIYCELSPVTDFREACCRLNSGEGCVRGGFCNFIHRKEPSPELERELELSTKKWLKERGRDERSMSRSPSPEPTRKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMG4</accession>
    <name>A0A1C1CMG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06793"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09915"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2587356at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06179">
        <property type="entry name" value="MFS_TRI12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053791">
        <property type="entry name" value="MFS_Tri12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="60"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="591" mass="63639" checksum="31BE4D1B409BDA09" modified="2016-11-02" version="1">MAEKDISQTTEVIENAAHAEERERERERERERQRAAEFEPPALHIQELNEAEHINLSWRSWLVVFVTCFAIMAQVFVVVAAGSVIAFIIRDLGDAPIAGWIIQGPLLMQSVLSPIVGRLSDVLDRKWLASVPPLIAFAGAVISAKATSMSMLIGGGILIGTTLSTIAIVQAIPSEVLPLKYRALANGFAFLGGAVGGLVGGLGAGGVTNARADGWRDIFWMQAAFHLATFFGLLFCYHPTRRSDYPKMSLKQYIWAIDPIGSSLFIVACTLLLLALDWAGGAYAWSDAHVAAPLGIGLGFLVLFCLYEWKGRDDGIVAHVFFKGSPNFALSVFSFAVEGWIFYSAVNSVTPQIVLNLGFQTDAWKISIRQLSYSLVSLFASIPIMLYATKYKDLKSPLIVTFTVFLVVCILYAVVKPSWNQAQYGINVLSGFGQSGPLTLIVALIQFTAPHAFLSTATGLGFSARAIGGAFGSAVLDAIINGRLKSYPNKVGGAAIEAGLPASSVPALLTALSSGAGLTDVPGINATIIDKTVDASHWEYAHAYRLAWASIIPFVVLALVGVWFLKGVKELMTEKVEATVEHVDKVDQEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMX0</accession>
    <name>A0A1C1CMX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07641"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08756"/>
    <dbReference type="eggNOG" id="ENOG502T8V3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4588567at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="192" mass="20917" checksum="A4C41445CAD1B623" modified="2016-11-02" version="1">MAVAQLVSLFETIHEESSIKTTSRSLRSHHHISSSKVRLHLQTIFSHNPLHRSNKSPSSDMASPTSSSTPSSRSSPSSSFSSFGSRSGSRVRAPVNDLDSAILSPVSALPSNQARSYRIRRQPSAIDLALQEEILYANEVETIGLGFLEPRPRANTASSIASSQQCSIMEFMNETAVTPVVLDSIFDVMERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMX4</accession>
    <name>A0A1C1CMX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07751"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08781"/>
    <dbReference type="OrthoDB" id="4155790at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="120" mass="13291" checksum="BEDAA75F7CC5A3E2" modified="2016-11-02" version="1">MQTRTILGAGALLGVGALAVTQLSFQSQDRQYKKTLAYMHDGREKIQERMNAMANTADTDGRGRRKEREFIREQREGVGNVEVFNNLPEIGSGSERATTGQPSVRAEDVLRKEKASITPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN08</accession>
    <name>A0A1C1CN08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF5872 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN08"/>
    <dbReference type="STRING" id="86049.A0A1C1CN08"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07510"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08789"/>
    <dbReference type="eggNOG" id="ENOG502SP6A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3360421at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28512" checksum="E12BA54B7D6481C7" modified="2016-11-02" version="1">MPSSKDKYTDPKLRDEVKEEVQQSDKGGAPGQWSARKAQFMAKEYKSRGGGYKTDKKDQDESQKHLSKWTEEEWQTKDGSGQAKQDDGTRKRYLPKKAWETMNEKEKNETEEKKQQGSKTGKQYVPNTSRARSARKKANDDEDEAFEKKKEQEKDEESGKQTRSKSRKVAPGERPNSKQDSPPKNASRKRVRDTETKGAVEGKPPSKKPKDSTESAKGKNKTTVSAKHDSSRPPAKQASKTRRQDKGRTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN41</accession>
    <name>A0A1C1CN41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN41"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11342"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08826"/>
    <dbReference type="OrthoDB" id="10387807at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="301" mass="33104" checksum="CCC3D7F1265D968B" modified="2016-11-02" version="1">MAPLARIVVGEVSIPVQYSIPDAQLFSQKWWAEATKTNLFWTQFKRYISRGTINKRIGLEIKTDVVEGTRGLQIHSNTAEPTRGKGRGRPKQRKKRMRPQSTSVASTPTATPGAEEQSEFESEADTMDERLESDELGIGGGEIPGSRRSARPRRKPALFHPVECTKCNKECAFSDISVRYDGTLLCEACNGTVPEVAAESIAVEVPTLSGNLFEPPKDTMAGPSTPAESPIVKLEDEKPGLQDMSATIVAATKTKRQRQHEDDGRILTINGQEWLVYADEKGDEHAVKLGSASKKIKIELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN52</accession>
    <name>A0A1C1CN52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN52"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07753"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650920" evidence="1">
        <location>
            <begin position="28"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="130" mass="14648" checksum="58489AE1FE3DD06C" modified="2016-11-02" version="1">MDSNHPHKGGALQVLVLSSFVVHCVQPFGNFTGFVVNWWHGRSAPEFDLEATWTVSGAPTDISESYFLTAFPKGDHVPMLYQLPATGVNTDQKDFDTLEERMNQPNTLVALVYVKQHVKRQQGIKWMTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNP2</accession>
    <name>A0A1C1CNP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNP2"/>
    <dbReference type="STRING" id="86049.A0A1C1CNP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07729"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09033"/>
    <dbReference type="OrthoDB" id="5322539at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="144" mass="15973" checksum="1B576DC9EBF3674D" modified="2016-11-02" version="1">MLISSDNLSFNYGGDLAASYRFDRVPSSAGEAEAQMMTCKLYNASYAAHFEAKSTDAQFITAAPAFKNWMPAVSTMGGTPADLLVSRWMNMQAGREVFAMMVTGPIKYSNKVNFPTTNSVYSLGMNQARRNETLFQKTRFKYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP06</accession>
    <name>A0A1C1CP06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Noorani M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP06"/>
    <dbReference type="STRING" id="86049.A0A1C1CP06"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06772"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05816"/>
    <dbReference type="OrthoDB" id="2578740at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="335"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="603" mass="68040" checksum="35AE0753B661ED57" modified="2016-11-02" version="1">MASESGAYFVAGIEVLEKPITPVDDAQAKYNGLRPSTTVLAKGYQKSPDFRPFEVDTIWERDIEVPTRDGKILRADVFRPAGMTDQKIPAMMAFSPYGKSGTGFFSLDIIPARVGIPKNRLSGFEDFEAPDPAEWCSYGYAVVNVDAQRIFGSEGNHKWHGAAEGRDGYDAVEHVSQLTWCNGRVALVGNSWLASCQWFIAAERPPHLACMLPLEGLSDVYRETLCRGGVPYLPFWDELSGRLFVDKTLGHNLQEDVISMIRKYPLMNGYWEDKRAKAHLIDTPAYVLASMSTALHTVGSIRCFEDIPHDRKWLRIHPTQEWHDLYQRDTIADLKKFLDFYTKGVENGWEQTPKVRVSVIKYNQPPIRNIPFTDWPIPETTHKTFWLSSNNTLQSGEAAVSGEVSYQSDAPHQQVDRDPEQVEFVYTFAETTTLVGPSRVVLYMSCADHDDMDVFVILRKADRHGKVLRNVNIPLEELGVVSEDEVEDLNTLKYIGPSGVLRASHRAIDPRLTKPHWPAHDHTREDKVPFNKVVKLEIGLWPAAIQFDPGEKMILRVAGHQMTLAEFPTLRGGFHTGNKGRHVVHFGGEKPSHLIVPTVRTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP26</accession>
    <name>A0A1C1CP26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor SPT20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP26"/>
    <dbReference type="STRING" id="86049.A0A1C1CP26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06611"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05736"/>
    <dbReference type="eggNOG" id="ENOG502RKFS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1932706at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021950">
        <property type="entry name" value="Spt20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt20-like SEP" evidence="2">
        <location>
            <begin position="113"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="946"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="706"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="989" mass="109446" checksum="0817A304FE8DEDB3" modified="2016-11-02" version="1">MAAVMAKPAGTATKMKKPPAPVLQTNINGHKPTAPSASPSSARKSLPGQLQTPTSATSNAAATNGAARPNRRLQRLTTRNTTADSGPQDKRAAKKYPEPYVPKETHILRKFKGCHPSLIVHLHPTHFRFDQQDGSFSYHSEMRVFIEHLAKGTIPHDMVEEFRNSDVKYYDGWLIVRVVDHKSAAKEALASGAAADDEKPFSIHNYNQYITPSPYAPFPTKEQSVAKSPPLKQEQTDQKGVPPPEQPVDVPPKSSRPQPKVYHVALRPTILSRHMDLVIDAMQPDPKSLTRKGSQANVSGRTAGTGAPQTPISGMPPTPSTERGPPFKKQKLKIDPKDMLEYEGRVVNATAPPLYLDPVENLEEAETLLDMLKDPLHDQRPPSPKSRKRTIAELAADDAQAKEQERFMLVMDERTAGTNGAGNAGAGDGQAAAALFQPRFEKFNALDNIKREIAERKQREKDRQLQEDETRRGQQERMQEEEKKRILMHRTQEARLMRQRQAEVAAAVAAQQQQPPQPAQRPPSSQVNGIPPNMRNQMMQGGSPVVRQGTPHMASSPVVTSAAQGGAPMAVSGSQQGHGSPPRPSSAVQHGHPSAPMTRGPSQQGPSRNGTPQIPHGTPAQRNATPIMRQNTPAQPVTHASPHGVTPQMMPAGMMPGMQAQMPNGVHRQQLNPQQMAELQRRHALQQQQQAAQQAAMQNGMVNGTPQISPAQMAQMQAQQAQAQANREAAIRQQQQQQAMQSQQGTPQTTHMSPNPNQNQKAYNQQVAEAMKAQMQSLQQGQTHGSPAPNHMTPQQQQAQMVHAQQQQQQRMMQAQGQMMGQGMPHPQQRVPMDSDAQRQQYQRFFQAYQQRFAAAAAVKYGGNPQMLQPQEVQQIKAQAQQMAAQQMHKQRQMGAQANQAQAMQQMQQLQARQQMAQQQGGGMPNGMMGMQNMQGGQVPPNMAQLLQQQQAQQMQQMQMQHAQQMMAQQQQHQQQQQQQQQNMQFQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP48</accession>
    <name>A0A1C1CP48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_07734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP48"/>
    <dbReference type="STRING" id="86049.A0A1C1CP48"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07734"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05720"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT50269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="142" mass="15649" checksum="EA0E4C6F2E21194F" modified="2016-11-02" version="1">MRRREVGVKAAMSAQNTAIATDKVLASGKQFGVSKARWPVKSAEFLIGLLKNAEANADTKGLDTSKLIVKHIQVNQAPKQRRRTYRAHGRINPYMSNPCHIELILTEAEEAVTKAAELGVDKSTRLSTRQRAARRQKAITAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPS6</accession>
    <name>A0A1C1CPS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative cytochrome c import factor (Cyc2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_07277</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPS6"/>
    <dbReference type="STRING" id="86049.A0A1C1CPS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07277"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05531"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF189">
        <property type="entry name" value="CYTOCHROME C MITOCHONDRIAL IMPORT FACTOR CYC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="80"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="250"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT50473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="395" mass="44649" checksum="F4F5A9DBB7CB2CB0" modified="2016-11-02" version="1">MFARCSRGTSKRLPKATCLPQSSLPRPRFNSSLPERTRKLPNARGSSAKLLTDWLLNRWFLLGIAFGVSLNEYFKRRGDDSFVTCTLTGKEPVSSTASIFHLQPKHRLENDELYKEAWRTGIWNVQFKQPQLQIVRAYTPLPPMDEKTGQEAGDLRFLIRHDPHGEVSSWLHRLPLTAEIEMRGPYLEYEITKHVRQVVFFAGGTGIAPALQVAHALFEGNKAVGQEDSARKDRKLHILWANRMRQDCLGGVSDDPPPESLPSKSTWSGFFSTPKPKPTPPQSAEKGPIVRELESLKQRYPGQVTVEYFVNVEDTWIDEDAVFRALSRFDDKDFSAGTPTSDEQRQILISGPPGFIAHLAGPKEWRNGREEQGAVSRIVAHALAKNPHHVKVWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQG8</accession>
    <name>A0A1C1CQG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CLCR_06631</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQG8"/>
    <dbReference type="STRING" id="86049.A0A1C1CQG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06631"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05298"/>
    <dbReference type="eggNOG" id="KOG0578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000535">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="85"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="592"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="268"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="359"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="359"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="447"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="506"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT50723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="882" mass="98168" checksum="92BEC8557CEECDE7" modified="2016-11-02" version="1">MASGQENGFYSGQFMNPGPAPRPPTDRPRHLELQRSNSSIPTATFESMSIAAPASPAVSTPSAPYFSNGSSLSLSTSGKPSGPVTIIKEGHVRCKEDKFLAQWNQRYLILREFRLDFMKSENGKLMQSIQLNTVTGVTRSEETRMAFEITRLANPKDVGGKVVTPRDLPTRTMTCEVRNDDEIYDWIDKIYERCPGMGGVSNPTNFSHRIHVGFDPQTGGFVGLPQEWEKLLNNSAITRDDYKKNPQAVIEVLQFVSDQKMREQHPEMYTPGMVTPPATQPNKQLGYSAGGNTVAPPRPAPPTDAQRYNANQFIKYQQDGPARTGTPPTKPQLQRAQTDKGSYDMEADAARIKAIAMEEQKNRQMEAEAKRARELERQQEREREEAERVRKEQDAYNASLPKSRPTMAQQEVGGYGGGPNRQDPRYNPARAAPSAPQQSSSLRQQPTAQRQAPSAPSSGSQKSIPQSASAGQTSLRSPDSRDRDRQPSPNARYPPKEPTRKDSAPKPQTNGVNGQSSTRSQGSVQQPKPLNVAKQPQTKAAADPRKEAEIALTAKKPVEERAKEVRMSSMSESEVMAKLKQVVSKDNPMESYSKQKKIGQGASGSVYVARVKESATSAVAREIYRTHGPKGQVAIKQMDLRNQPRKELIVNEIIVMKDSKHPNIVNFLDSFLQEQNNELWVVMEFMEGGALTDIIDNNPVITEDQIATICFETCKGLAHLHSQDIIHRDIKSDNVLLDRVGNVKITDFGFCAKLTESKSKRATMVGTPYWMAPEVVKQKEYGPKVDIWSLGIMAIEMIESEPPYLNEEPLKALFLIATNGTPRLKNPNKLSRELKAFLSVCLCVDVRSRASAEELLRNDFMRMGCSLASLSELLKWREKGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQQ7</accession>
    <name>A0A1C1CQQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07248"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05217"/>
    <dbReference type="eggNOG" id="ENOG502T54W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4157504at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="44652" checksum="646124D661BCDCC1" modified="2016-11-02" version="1">MSIPTIKVLGVSVAAASGSRDDKKVNSRSTLSLHGRVSVFNQDGSFDTVRVRLQGAIRTKIGSQVAVEKIPATSVTKTHLDFKPVYSATRQRTEEQYLDFTCAVPTPRDGAPEAFVPSMTLSGTTYLTKVTALTNRELLKGSCEVLYTLEAEFVRSETNQLVRRISCPVDIPSSLAPLDVEVTSSGPSDKVEEVAKPQLRSLNRFLGSQSQPGLSVEVSKMLGCIVSDASTVSTGCRRLTVAVFVNVSLPSNVRRRAQTLWENEHLKLSAKAQWLTRRTFTTGYSAVESTVHSDRVLTQNYAVSLPPLYESSAESSKYTTTVELDLLLPESILTPTISTDILNINHTLNLSMKIEASENGLLRSPLIANFSLPVALGASQANSMISRRTVDPLLGLVEEQSLFAPPPYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQS6</accession>
    <name>A0A1C1CQS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">OLE1</name>
        <name evidence="20" type="ORF">CLCR_08514</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQS6"/>
    <dbReference type="STRING" id="86049.A0A1C1CQS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08514"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09495"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="354"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCT50849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="480" mass="54364" checksum="EF99D8246A109037" modified="2016-11-02" version="1">MPSSQPTAGDLAVKPEFQSPQPPTMAKPSEPNRSTKYDPKKPHITETPMTKSNWYKHVNWLNVTLIVGIPVYGCVQAWWTPLQWKTALFSVLYYFATGLGITAGYHRLWAHTSYSATLPLRVFLAAVGGGAVEGSIRWWARDHRAHHRYTDTEKDPYSVRKGLLYSHLGWMIMKQNPKRIGRTDISDLNEDPVVIWQHKNYLKVVMFMGLVFPTLVAGLCWGDYLGGFIYAGILRIFFVQQATFCVNSLAHWLGDQPFDDRNSPRDHVITALVTLGEGYHNFHHEFPSDYRNAIEWHQYDPTKWFIWTCKQLGLAYDLKQFRSNEIEKGRLQQQQKKLDQKRSKLDWGVPLEQLPVMEWDDYVDQTKNGRGLVAIAGIVHDVTDFIKDHPGGKAMIGSGIGKDATAMFNGGVYMHSNAAHNLLSTMRVGVIRGGGEVDIWRRSQLEAKGEVSRDSSGERIIRAGWQPTKVIQNTPTAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQZ0</accession>
    <name>A0A1C1CQZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09164"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09563"/>
    <dbReference type="OrthoDB" id="2117996at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650986" evidence="1">
        <location>
            <begin position="20"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="189" mass="19344" checksum="DADBDE1D384DCC3F" modified="2016-11-02" version="1">MKSSVAATTLFALISASVAAPSNLRFAKRDLPSGDCVAPGPDATANAINAWDSDVRTVNAFLEAAPTLGSVDILLSIQTPLTAAEDEPNQLQVLACEPAVFEGTKAQAAANALFDGFDDNVIVPLGNIVASPADATNVAHQLATINQFRCCTVLPSLDILWPTTAANEGLVGSGPIVAPRPSTCAAITC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR21</accession>
    <name>A0A1C1CR21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DPPV</name>
        <name evidence="8" type="ORF">CLCR_08089</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR21"/>
    <dbReference type="STRING" id="86049.A0A1C1CR21"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08089"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09600"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF13">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="7">
        <location>
            <begin position="494"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="738" mass="81894" checksum="9CD3380C5D0B20EB" modified="2016-11-02" version="1">MTIRKQYTPEVLLSAPRRSAAIPSPDGKLALFTQSSYSFQTHARTSEIRALDLTQGTETTISKDAKASEPRWLGTAYEVVWLKETENGNTNLVVTDATLPGKSYTAGTVPGPVSSLKLHVIQPGKVAIAVAGQANPDGNLFNPKDAPKSHTSARVYDSLFVRHWDSWVTEQRNALFTALLQKAQPVVTSRQGRYSLHGFKNALQGTNLECPIPPFGGVDHFDIGPTGLVIVAKDPLLDPATHTKCDAWFVPKKDLMDVSPTSFHKLHLPGLDGAASCPVFSPNGQSMAFLQMAADGYESDKNRIVLVQGLNGVERGESASVFELMRTPDGQGGWDRSPTALKWSPDGNMLLLEAEDTGRGCLFALDLNAAPSPEWRPRQLTHSGYIIDFAPLSTMSNLLIVSSNNLVDNSVYTLVNPDPLLVEPQAPVVISSLSRNGSMFGLSPEQVSSIWWKGANDHPVHAWMMRPSFFRADQTYPLAYLIHGGPQGAWNDQWSTRWNPAVFAEQGYVVVCPNPTGSTGYGQAFTDAIRNQWGGLPYEDLVKGFEYIRAELPFVDTARSVALGASYGGYMMNWMQGHALGRQFKALVCHDGVFSMTGQLASEEQYFPVHDLGGPLWKRQEVYDRWDPSRFLTHWDTPMLVIHNELDFRLTISEGLSAFNVLQMRGVESRFLSFPDENHWVLKPENSLVWHLVVINWINRFVGLPKIVDRQGRDGSGFCRRESRRVWPKRQGSSKLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRL5</accession>
    <name>A0A1C1CRL5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dimethylaniline monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_11365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRL5"/>
    <dbReference type="STRING" id="86049.A0A1C1CRL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11365"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06924"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT51147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="71892" checksum="038F5568E3384E49" modified="2016-11-02" version="1">MPVTVAVVGMGPLGLMALKNFKEDGFEVHGFERRHWVGGLWKQSFDTSLSTTANTVFNSSRFRSAISDFPFPEEVDDFPTAKQMWRYFEDYCDAFELRPRIRFGADVQTFSRKRGKWAVEYIQNGTSHTEYFDKLAVSPGSFVLPRRPRLKDIETFQGTVLHSIDFPDPSTFQDQNVLLIGFHATAQDLVIELSPHAKKVYIAHKNGMVLVSTVIRPHVDPHLSYPILSYPILSYPILSYPILSYPILSYPILSYPILSYPILSYPILSYPILSYPILSYPILSYPILSYPILSYPILSYLKRDITYDQAQTLSVLFLQIFLSKWFPRVWDWLFDNVIGSMSRKAFPEQRREWNLTPAPSATTTPPLIADAIYPFLESGFAEPVAAVQQVQGPNAVLLTDGRLLHDIHTIIYTTGYESAIPCAPREYNPYPGADEAPVLYRNAFPLHGDADVRDSLAFLGQGGIAFPGFVQFELVVFAVSQVWRGKAHLPPLGEMQDWHRGHMAWRRDVTRRSIFDTKLLPVILRLPDQIEWLDKTAGTGVFAHFSWFSWLSWRAWRFWWQDRSFYRLCKAGVCSPAVWRLFDMGGRKPWKGAKEQIIRDNELVEKRREARQRAVKKTQQNQKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRY4</accession>
    <name>A0A1C1CRY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_08355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 11">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRY4"/>
    <dbReference type="STRING" id="86049.A0A1C1CRY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08355"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06846"/>
    <dbReference type="eggNOG" id="KOG2901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5595109at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT51233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="564" mass="61378" checksum="590F56A2E72C3AFF" modified="2016-11-02" version="1">MRYGGCRLSERKPTLTSCLYQSFSSRLCPTPPSFRNHDPPTPPPRRAFTQASSRPTQSSPSLPARTWSTPLAKTIAQAIEVTGPISIASYMRQCLTNPDGGYYTKRLPTSSDADQFGSAGDFITSPEISQIFGELVGIWFMTEWMAQGRPSAGVQFIEMGPGRGTLMSDVLRTIGQFKTFANAISAVWLVEAGDGLRKRQKDLLCGETAALNEVRDPSGKNVWFEATGKQGIPVRWVEDIALLPGRGEDEGKTAHATVPFIIAHEFFDALPIHAFESVAPKPEEAERDTKAQLLTEAELRRQRSSMASKLPQWRELLVASTTPNLTAMLSRDGEKSSGHKEPDPEFQLTLAKASTPSSLVIAERPRYRALKSQVSSRVEVSPESSRYVMDFARRIGGDSQPSTPSSVSKSIPAGAALIIDYGPLDTVPVNSLRAIRKHKVISPFVYAGDADISADVDFAALAEPALEASPGVEVHGPVEQGMWLTQLGIKERAERLMKELAAQKSSESADSQEIEKRKTDLETGWKRLVEGGPKGMGKAYKVMAIVPENGGKRRPVGFGGHVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRZ6</accession>
    <name>A0A1C1CRZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative C-4 methyl sterol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_09215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRZ6"/>
    <dbReference type="STRING" id="86049.A0A1C1CRZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09215"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06805"/>
    <dbReference type="eggNOG" id="KOG0873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000254">
        <property type="term" value="F:C-4 methylsterol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT51277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="164" mass="18891" checksum="6A074F98843749A5" modified="2016-11-02" version="1">MAWQIALFFVLEDAWHYWFHRALHTPKLYKMIHKLHHQYSAPFGLAAEYASPLETMILAFGSVGIPIAFCALTKNLHVITMYLWIVGRLFQAIDSHSGYEFPWSLHHFLPFWAGADHHDVHHEKFLGNYASSFRWWDATMGTDVGSASEGFKRKAKKAGEVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS56</accession>
    <name>A0A1C1CS56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS56"/>
    <dbReference type="STRING" id="86049.A0A1C1CS56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08897"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06751"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="289" mass="31075" checksum="A5DFBD3B8F6C0C4A" modified="2016-11-02" version="1">MELPTYTKQWHNDVYPDIDASRPELSVKGKRVVVTGGGGGIGSATAKAFIAAGAAEVVILGRTKQTLEATKSAIMSKHPNANVVSVVVDISQAGSVTEAFASIAGRGLIDIFVNNAAYLSIGTVGTSDPTEWFKVYETNIKGSLLVTQAVLKNINPKDGIIINVTSAAGHVPYVPGYSAYASSKLASAKAFEYLQHENPDLKVFNIQPGVIESTSLATKAYEQSGITFPQQDTVELPANFMVWLCSPEAAFLKGRFVWANWDVKELQQKKQLFENDPTLLTVGLLGWPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSL6</accession>
    <name>A0A1C1CSL6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_08252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08252"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06587"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF62">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="490" mass="54575" checksum="6761AEC188FD584C" modified="2016-11-02" version="1">MSSEKETPMPPKRFSLEEKAEIAKHVDLEQDVTLTPQWRAQERRVVKKLDMTLMPTVWILYLFNYLDRNNIAQARLNSFEEDLGLVGKNFNTAVSILNVGYMLAQLPSNMILTRVRPHLYLPLCAALWSCVSASTAATHSYGGLIAIRFFLGIVEAPFFPGAFYVMSCWYTRKELALRTAVLYSGLVLATAFSGLIAAGVFAGLDGVSGLPGWRWLFILEGAGSFVAAVIAIFIMPDYPESKTGSGRWLFSEEERKFAAERIARDRVSQPEADRSVWYGLRLAAKDYRTWVFVLMLCANHTAYGFNSFYPSIVKGFHLGSTTKTLLLTAPPYLVGAAVSFLVAYSSDHRKERGFHISVPMAVAMVGFIISVATLNVPARYFASFLYTSGCFSANAMVYTWAASTLNQTPEKRACATAMINLLSQFGNIWSPYFFPASDAPRYTMAMLLMLGFSALSICCCIVMKISLRKGNEKMREEAEESGREVVLFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTJ2</accession>
    <name>A0A1C1CTJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08996"/>
    <dbReference type="OrthoDB" id="4161385at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="266" mass="29269" checksum="433202A47A8C749E" modified="2016-11-02" version="1">MGTSYSTPTIRPKDLDRWNRQGRPVLIDECRRARSPGGGRRHVETRRRYTRGDPFGGFALNGGGRRPIHPTAGNGFGTTPPWPGVYPNPLGGPDVVVGGGFGASYTDGIPVFDRPIVVERMPVFFERPRLVVEEADLDLFPGGSRFGRQDEDIHLRQPPRFMFVSPDDDDGDDHDLPPRWAHRPPPGFRFAGNTFQPRRDGRFDGGGYGGHRSTGFGTSPSRFSSDIPDDTSLESWGPVRGGRSPSPGFIFAEDGVPLRGRTSRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTL9</accession>
    <name>A0A1C1CTL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_08813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTL9"/>
    <dbReference type="STRING" id="86049.A0A1C1CTL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08813"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06305"/>
    <dbReference type="eggNOG" id="ENOG502RR13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4155372at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39900" checksum="431859902171674E" modified="2016-11-02" version="1">MTAIVMDDPMQPPPSPITVKQALKDLQATLNQIRRKLRTLIDWYIIPHVVPDSIKAYDPRLQILQLRLRSLSTIDFQQLPYIIDGSDAVAAQYLGELVEQMQHSVRGIQTIFVEHYDPDLLDRRPFAMVWETLLYRQDQIRQLPALNPSNPGRRMPEDMHPAELGNFCPGALGISNRRDRGRISFVEKKELNEENRRKLKAFGGAYLNWQCPDCAYKVRYHVTNSTTSNIHTTDEVREHADLLIQYRSSFLAKCHLFLPQPEKVSISSNGSSTTRRESHAHIKYGCVFCFATGEELVRGCTAFTTARDFAEHIAHEHRNPLPPSLLIHRFSVAAEGKTVIGGRWDLNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU89</accession>
    <name>A0A1C1CU89_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_08480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU89"/>
    <dbReference type="STRING" id="86049.A0A1C1CU89"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08480"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06066"/>
    <dbReference type="eggNOG" id="ENOG502SKED">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5429770at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT52071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="498" mass="54975" checksum="7D9014EF4F817B89" modified="2016-11-02" version="1">MVYNGKPSKACVHCRRRKLRVLLHIPDAPDALSLTISQCDLRKEACGQCVRAGLTCTGYRDPGQLRIQDESESTRQRALGLKSRLSTSPIHVPLEEMARAAFFSHYVHGFSTTYDVLELMSRQSGLDKHLAASVDAVSLAFFTFQYDAVSALKPAREKYLSALPLVKAALGAPEFLASNSTLLAVLLLDLFEKITNRSPISSESWMSHVRGALALARLRDPAQLDTYIGLRLSVRLFTNMLISCVAANALIPPALIKLRTELQAHMHRDDPKWRVSGLVMKYANFRGALQGGLLAHAEILKSAKKLDGEFSSLARDLPPCWISQRVALHKPSSAVLEQYYDVYPDHFTAQTCNVIRMMRILLNDLIRHTYLKTVAASGYPDPQALNVGFASHIIDSMAKEICAAGPQFSGIAEAHNRASNASPSRRMHCYTLLFPFYVAALSASPKTGVRDWVIQRLRAMATDLGIKNAVSVAEMLERRDGTSPWSVYAILGSYAFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUL7</accession>
    <name>A0A1C1CUL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAP domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUL7"/>
    <dbReference type="STRING" id="86049.A0A1C1CUL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08936"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05995"/>
    <dbReference type="eggNOG" id="ENOG502SD2Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3993201at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="273" mass="29952" checksum="D24D2FB57994FF8D" modified="2016-11-02" version="1">MAAPRASSFKALRNLQRTSGSTSAKRSLHITGVHESPRPIDPNHKTTYMPWNLQDLRHECQKRTLSASGTKHELIDRLAGHDSLQARAFSIAMKRIAVEQTRKPVSGPSEAAPQRHFNTSRALKAVGDTSTIDFAYLPKLFEESWGPAPAAIRVPILPNIQSDHAEAVLEKYPELDSAAGGYQDTPGHETILKPQIFHNGDSEGSVASALSDVHDGHPTELSVEMLTALTETVGKSARQFLDQVKDKDEQTIRKIWSGFLDDVFGEKRKGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUT5</accession>
    <name>A0A1C1CUT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Voltage-gated hydrogen channel 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUT5"/>
    <dbReference type="STRING" id="86049.A0A1C1CUT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09257"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05895"/>
    <dbReference type="OrthoDB" id="427456at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="14965" checksum="93EA1C14F71AB9BE" modified="2016-11-02" version="1">MAAFAFAIDLVLRTGGGPLEEAGSLVVVLRLWRVFKIIEEFSSGAEEDQLAELQERIETLEKQKDDARKENEQLQMQMRMQLRVRSQEGNANGSANGFEGVDGYDDGHAAHRTRTGTATGTAIGTVPSRGEVDGEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW35</accession>
    <name>A0A1C1CW35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_09606</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW35"/>
    <dbReference type="STRING" id="86049.A0A1C1CW35"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09606"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04103"/>
    <dbReference type="eggNOG" id="ENOG502SJ8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="676"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="768"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="693"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="771"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="784"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="853" mass="93171" checksum="21FDC62B419D58D5" modified="2016-11-02" version="1">MSHAGSSSTSPYNPDTSGALFSHDQGPPRKKMRKGTKSCLECRRRKIKCTFEPGRPAVCNECYARGSTCIDQEHGDIQTYTQAASEQSSYSLRERVSQLEDLVKQVLHRLPEKGASTSVEAEGDGVPSGTESDKSHVDAQAAEVLKSLKSSLRQSDASIEGSILLPGGLRDDAPALTLFDNAVIERKESQPVVSRAQYNKTKTLLAALNKLLPSPADLEVILEQSHEWWTIWKKMFPEITDRRCETIKESVSHSLRSEKPAELAKIMLCIAISIHQLPNHFDWSRLHIKEGPADLMERYIATVDKLITSDDEIAATLDGIECMMLEAKYHVNMGRPRRAWLLFHRALAFAQLLGIHRLAAQADRTSLDYQRSVNIWCHLVIGDRYLSLLLGLPYSVSESFVTPYISAAGPPPNSVNDGEYYVGKMVPIITKMIDRNQSVVPMGYSATLRLDQELEELHNAQDPAWWSLELIPGARAEDHFDRLSAHFYHHQAKLLLHMPFMLRSSTDKRYQYSHNAALDAAREMIRVYEALRTNQAVGPFICKLIDFQAFTGAMLLLLNLCGYSQRHRGNNAQQTDLEQDQKDSDLIDKTIALLKDAAKEPGGVVAAQSAQAMEMLARVREGTDDGGGAAECRGETCQVSIPYFGTISIGTGKHFVPIKPGTYVQRTSGGVTVNTTTKAGGTMTNTGLPTPPSASSNSTQPSPLSTTLDQHSSHTQQYAQPHRASGYAVTSYVAPGLDQWPDATDSISDDPFVTFDSFMAFPPQPPTDVPSAGGVSISSSGSGFTPQPIQGSPYNPSGGTPNQHHDMNASVAAGGLAGLASSGFPFGGFPFGQSGVDLDQGWNWFGVDAPVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW68</accession>
    <name>A0A1C1CW68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 10">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_09604</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 10"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW68"/>
    <dbReference type="STRING" id="86049.A0A1C1CW68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09604"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04080"/>
    <dbReference type="eggNOG" id="KOG3754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="608"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="610"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="642"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT52701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="723" mass="81852" checksum="11BC8A28744E63C2" modified="2016-11-02" version="1">MEPKTNPRWDEVQSRSERIRDRAMQQLLDVFLVYKDIDNYPPFWGDEIEYQLLSFDKSNKTVRLLLEQDDVLNKLHGREESQEAGRRHLLHRRDESQDADVQPSPRVDKEPKPIFQPEFGSFMVEATPGAPYDNSLTSMLSVQGNMARRRRMIQERLGENEAVVTIPGFPRLGAPGTFTQPPLPSGGLLLRSQFLPDGLVSTYERYGAIHDNIYTRREGRAFKIKVPIFRDEKTPWPWRESNHFGQANGVQEHDAGIYGHHADNFIYGDSMSFGPTFCGLQVTLQARNLREARYLHDQLCPVGPILMALTAGTPFFRGFLTDTDVRWNHAAAAVDDRTSNELSSKTEEASIQPRWAPTAMYLADDARLRSEYNNSSTNPDPNGTIAEKLQNKGMDALLASHYAAILARDPIAMTEKDLEAYAHGDGDGDTDADIDVFEILHSAVWPHVDFKLPSKKEGRAGWRVELRPLEIQLTDFDNAAFVVFVALLARTILHLDLNFYIPIDKVAENMTRAHTRNAVMEEQFFFRRDVWSSSSAATVENAKDKGTHPPVETEFTSMTIDEIMNGSKRLCSDGSQCGNCSTSSSSSCSFEGLIPLVERYVREVYAGGSEDTHDRKQDHQQGHELGHKHEHGHQHGKQQKQGQEKGQEPPHRDDQEHGANQLLKYLAMIRNRASGKIPTPATWMRRFVQTHKDYRQDSVVSEGTCYDLMCCVRDLGDGDARIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW83</accession>
    <name>A0A1C1CW83_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_09792</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW83"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09792"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04088"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF27">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="44"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="578" mass="63063" checksum="C167B126CC549041" modified="2016-11-02" version="1">MAFTGAKNHAAAHEERVDEGVHAEPALDPVHHPTGFWNWRLIVNMIIIGLSLGLYGYDNNFVAPLLALPLFILKYQGHGPAFTVSVMLWILLPILSLTSILARNLDLIVTVPLVGDLEISDDFTAASGSFVAVPLMKRIGRKKTMMLAYFLLCTPGSILQVFAPNTGALVVGRFWNCKQLPEYQLLVSPKLILLDVGISVLTTTAPLYLTELVPAHIRARAVGFCVAGVCVVAIIATTIVWGTEKIDDSRQYKVPLAIQATCPVVFGVLMLFCHESPLWYVQNGKLDDARRALMALRNNATELVETELSLSQAAVVAERERREQSRFWDILDRTHLQRTLIAGTLLCSGQVGGQILMQTYSTVILVQSGVADPFQITIIITCLQFLGTMVGPVLVDKVGRRPVALAGFSILFVLDMAAGSLAAAGLTTKGQQLGLAAVFIVFAFFNAASIQSLAFLLPAEIPTPSLREPTMAWSTFWSYCTAVITTFAVPQITAPDAGNLGAQAAFIFGGCVFVTVIWSYFYIPETMARSAAEIDEMYAAKLPMRKWRGYKSQTVREVMVDVRRESVEKEAAHPGSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWW4</accession>
    <name>A0A1C1CWW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWW4"/>
    <dbReference type="STRING" id="86049.A0A1C1CWW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10296"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04279"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04280"/>
    <dbReference type="OrthoDB" id="3202396at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025444">
        <property type="entry name" value="Monooxy_af470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13826">
        <property type="entry name" value="Monooxy_af470-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35559" checksum="60EB7AB06DDDE170" modified="2016-11-02" version="1">MGVKTLFPPSAVKPRSQYAIGANIANGRTGAKKTGFGSLSGADVALLRDNFSVSTWLLLGGAIQVLLSFVFPRSYLAFPIVGLLGWRIVDAYLMHFGIKKNVWAEGVIEGKWSVGYPSEGETEIVHGKPGDNGPGAVMILGARSNSPLGMFGDGYKEVADRFHDMLVQLEDKAEESGFMGMSTWTSAGERPTSNELATISYWRSVEDIHNFALSPVHREAWNWWNDTVSKHKHVGIMHEVFALPERQGWEGIYINYQPTGLGMTTKAVESPEKGGQKLWINPIVDASRGVYRSSRGRMNRGDPEGKSNDSVIAKHPYTSAVLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX60</accession>
    <name>A0A1C1CX60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX60"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10926"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00088"/>
    <dbReference type="eggNOG" id="ENOG502T5DM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4153075at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="164" mass="18015" checksum="E05BE4EA06BC26F1" modified="2016-11-02" version="1">MAALHHPTSRSSPESPQSADSGSGRSSATERKGSSSSTHSTPPTTPGSSPRVQLVPYARTASFDISLSEAERELVDKMATQFDALDLSSKDFDFDEIFTYDKPQRKLIKGVVEVSSPTRTQRDWSSFSFSHYSAAMNARNKVNHKVKPSIGEMYVKKKPHGSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX67</accession>
    <name>A0A1C1CX67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX67"/>
    <dbReference type="STRING" id="86049.A0A1C1CX67"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09787"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04412"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06634"/>
    <dbReference type="OrthoDB" id="4156601at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="19"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="652" mass="73201" checksum="68385B3C803B88A8" modified="2016-11-02" version="1">MSDNGNLEQSRPSRKARTAREWEEARPKIKDLYIIQNLSLSETMAEMEKGGFLAREKLYKEKLKGWEIGKNATREDWLAWAKLYLEKRAVTNSSEIYIQIHNKIRRIQELRRYIKNHGVREEAFFDEAMRSEAPVPRYIRLCNQDGSSAADAEPSKPQWQAEVSPPRRQISLHRRTTRARNDTSDLSLQEATSCTCTGDDSDVVDRLQAMEFESALLESLQAQAHSRQNPQQNASQFAMDTVENSEPFDATGTDFLFARPEVPDDAVHFGHLSSLSSFQCVAVGDADALHQNIGNAPPSYFAHDTPPTNVTTDTFEQVQSSTPASNDADAQHAYAAACMIAAMLGAAGRKDKMARCLERAAGFFRQMCRFQSPGILTAASVVLTWLLVHAEGTLSERVIAASFVAATESLGRDNPVCLLLEWMTAAAARSKLRECRVASSQLWDIWHGFRQTLGEAHGHTIVALYCLSMQLILADKAFAEAEQYLQGLTPVAANVFGLSHALTINALATLSRAQLRQGKCLLALDTIDKSLTAAPLGLNHPHRLELLLRKALILRKLDQWDETEQLYWIVFKGRVATLGWQHNETSAAHDSLVWVMKERTGNWEAKKDEVHQCLVDPQVSVSDYESWWRRFVEANRATHIEDQDASGEEEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX76</accession>
    <name>A0A1C1CX76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX76"/>
    <dbReference type="STRING" id="86049.A0A1C1CX76"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10126"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04419"/>
    <dbReference type="eggNOG" id="ENOG502SSMF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="76224at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013240">
        <property type="entry name" value="DNA-dir_RNA_pol1_su_RPA34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053263">
        <property type="entry name" value="Euk_RPA34_RNAP_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155">
        <property type="entry name" value="ACR243WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34.5-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08208">
        <property type="entry name" value="RNA_polI_A34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="431" mass="46627" checksum="7E63404A4BC6B41A" modified="2016-11-02" version="1">MAQAARSDPLSAERVYDSSDEDEAQGVAGHDALPSNSKTSNGIKDDHEDDDSSEVEASESEDEETAEDEDESEDDQSESETGSAVTPASSQKTRSSPTPELEETAAKSVQSRAAIPAKPFKAPKGYEPIARSQSDSSSTVRQFDDLSEKEVWLIAAPGDVPIDSIKELAVDAVMRGQPIINHNGIAYGMQPLPSKNETVLLPQGVDASYQQAEKKIGRSFIMREVNDQTKVSSREGTLQAFTATRPGKPKEIRQQPEGLKKRYTPPGVPAGTAAQSGRDVEMDDAPGPTPAKSPSSSGSLDPRANDQNVPGKNPGKKIILYLGRDDTPDSSEEDFMQPTATPQNEPFMCHWRGCALRFDCCVELKDHVNADHVGARNSKGFTADCAWGNCQYSAPNGKRDFIHSHIASHTTSAIRAELRAREQKRTMGRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX81</accession>
    <name>A0A1C1CX81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_11005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX81"/>
    <dbReference type="STRING" id="86049.A0A1C1CX81"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11005"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04330"/>
    <dbReference type="eggNOG" id="KOG3006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT52990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="130" mass="14387" checksum="87B19D5CCA49D47A" modified="2016-11-02" version="1">MASPITCHVLNTLSGTPASSLKATLTLLSSNSSSKPQPAVAFTASTNEDGRVKEWEPSAGKSLQEVMEGYSAGERIAWSIKFDIGPWYEEKGVESFWPEVEVKFYVKKGERHYHVPVLVGPWTYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXM5</accession>
    <name>A0A1C1CXM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10963"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00121"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="147" mass="16113" checksum="AA9A9B7E590CCBB3" modified="2016-11-02" version="1">MPSPQQIPPSGVHQGTISFPIAVLPQLQAWVGGEWQRLADEQRVPQLNQTQYQELRDLIERATRLFGFTHEVRQRRTKKPAQSAQMIPTLGPENANTAPPSSGISGAVPNAENYAHGAGEDDLAGLFVGSVFDPQDPMLHLDDFATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYF5</accession>
    <name>A0A1C1CYF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_10300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYF5"/>
    <dbReference type="STRING" id="86049.A0A1C1CYF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10300"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00535"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="247"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="249"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT53574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="343" mass="38936" checksum="4C8A9BB2931A8771" modified="2016-11-02" version="1">MDPYGSYVCPSDFEAGRSQRSSAPLDDPKLLLTQQPHQQQQQLPPFREIEPPSPERLPTGSSFENFDNMSAQSADSAYAAHRHHRQNSSWTSPSHYTELVSPYGSQQRAPCTVQTQFAAPKPEPSLPSIHDLTYNQSFPTASPYSYGGSSGAFADHRSYPIKTESPYSIKTESHAYYEPAHRYGQSYQQMNRPQPPTMDYQRYPSALFDYPKGLAYSSPYGVEYIPSPTGSHHAVSPTVSNGESCGPGNRRRRGNLPKHITDYLKNWFLAHLDHPYPTEDEKQQFVHDTQLSLAQISNWFINARRRHLPTWRHQAQENSRRAAQASAAEYDSEQGRRSHKSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYN1</accession>
    <name>A0A1C1CYN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Diacylglycerol pyrophosphate phosphatase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DPP1</name>
        <name evidence="9" type="ORF">CLCR_10493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYN1"/>
    <dbReference type="STRING" id="86049.A0A1C1CYN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10493"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00509"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000017">
        <property type="entry name" value="Diacylglycerol pyrophosphate phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="104"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT53548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="322" mass="36137" checksum="8BCB47DDCFC44AA8" modified="2016-11-02" version="1">MRQASVDGPGIVAAFRRFWQRSYAAEYLGIILLLTANVWAEYFLEPVHQMFRLDDRARQYPHALVERVSSLENILFAGVGPLVLLIVWALVFRPGVHKAHVTILGLFISLLLTVLLTDIIKNAIGRPRPDLIARCKPERGTPEHDLITIDVCTETHHHTLHDGWRSFPSGHSSWAFSGLGYLSLFLAGQLHVFRPHADLARVLIFLAPLVGASLVAMSRLADYRHDIYDVTCGSLLGMAVAYTTYRRYYRPLRHLKCDTPYPSRAGYTSKKAPNIRSRDLEEAAEQFELSVSDMSEDEPHSYLLTGSGQADPRQHAGTAEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ99</accession>
    <name>A0A1C1CZ99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ99"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10820"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00761"/>
    <dbReference type="OrthoDB" id="4139647at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="215" mass="24209" checksum="52258A0E5466C768" modified="2016-11-02" version="1">MEGQSHVVASLDDLADLLERHSQLSTTCDVCTISSDKVEVKTCSGPTAQYTGCCARNVCLYCVMAAQRDVSRLKHQEHELHYCRPCSLAVQAQQRRQCCQCDSQTRGDVLDQSRAEWQCPPCRLLVSGMLEHLAHDILWHAEDEGRVYPRDQYDDGRAGLKRWLDPADANRNLCPGCGSDYFEIVESFDGAELDDSSKLPKDLVRQCILCLEQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZE5</accession>
    <name>A0A1C1CZE5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TYS1</name>
        <name evidence="14" type="ORF">CLCR_10309</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="12"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZE5"/>
    <dbReference type="STRING" id="86049.A0A1C1CZE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10309"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00832"/>
    <dbReference type="eggNOG" id="KOG2144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000004">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="346"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT53917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="413" mass="45569" checksum="41593AF1FBF0623F" modified="2016-11-02" version="1">MAGKELSPQEKLALVKDQLQEVLHEDILENVILKEQRPLVIYWGTATTGRPHCGYFVPMMKIAHFLRAGCRVKILLADIHGFLDNLKAPIELVKFRAEYYKYIIQSLLKAVGVSLEKLEFVLGSSYQLSADYTMDVFRLSSVVTEHDAKKAGAEVVKQVENATLSGLIYPLMQALDEQHLGVDAQFGGVDQRKIFALAQETLPKIGYKERAHLMNPMVPGLAGGKMSASDPDSKIDILDTADAVRKKLRKAYAAAKEVEGNGIISFVEYVLLPISALRHPEGQGTFECKRREGEGEPLVYHDIKTLKEDYLADKLTPQLLKAGATEALVDLLAPIQAEFQASPEWQDIEKKAYPPAEPAKKKKQPKDKGSRYPGANVTTNPDGSIEGRGKEQVEVGNTAEEAMSNLEINGQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZL5</accession>
    <name>A0A1C1CZL5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_10478</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EFG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZL5"/>
    <dbReference type="STRING" id="86049.A0A1C1CZL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10478"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00800"/>
    <dbReference type="eggNOG" id="KOG4484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47732at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="296"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT53881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="346" mass="40325" checksum="B542018A9EB668FF" modified="2016-11-02" version="1">MAKERGPPHRSSTRPALNSYRPKPTGTDTYRPKWAPRDHGSRPDHPRHYESYRPGDDGGRKRREESQQEDAHSLPPVRSAVTKTKHERATNPSTRIHSLKNQLQKQELPGTIRQEKERELAALLFEQEQNKLRQEARKNLQRYHFIRFVERQKSERNLRKLVKQRDSCNDENARKELEKLIHVTEVDLNYAKYAPLGDKYISLFPNDHTDNKHKKRREKFQMNRLDFAVLDEEQQKELRSQYDQAANVVRSASGDKPPMWYQIEELMEQGGAQLGLLREGKLTTGKQLKTSLATLGRKEDAQMRSTSGRDLTEAKPEWLDDNGVIDRADLDSDQDEDMSDGGFFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0F4</accession>
    <name>A0A1C1D0F4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0F4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00332"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10162"/>
    <dbReference type="eggNOG" id="ENOG502RVWS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4157208at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="191" mass="20900" checksum="3A04D224462BCC4E" modified="2016-11-02" version="1">MSSYPRRSARLSSQHLHQEHFQQRSGTLSAPAFANSFSQPSSASTSSHPSPVSDSMHPPPPPSTPQQPQNRLQIQPHYMQQPQQGQSHMNAPLPSPSGAEMGPFFGRPYSQPNPYASQQLPGQQPFGGQQPQMTQQGQPHHLHPHTDSMSQDHPAHAQAMNPGQLPPDFLAEAAKRAQMACLMRDIGDISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0R6</accession>
    <name>A0A1C1D0R6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0R6"/>
    <dbReference type="STRING" id="86049.A0A1C1D0R6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00974"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03714"/>
    <dbReference type="OrthoDB" id="4155662at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="31"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="157" mass="17089" checksum="934CF9FF5D192413" modified="2016-11-02" version="1">MSTVILDEETKSSLLQDLTDFFQPSTPRGFLWHGSPGTGKSSSSVSIAGEFGLDIYMVNLSSIDDKGLLNLFPELPQRCLVLLEDIDATSSKRAEVTDLNWDPKNIGSPPKREIREKVSLSPLLNVIDGIGAPEGRVLIMTTNHVELLDDALVRPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0S4</accession>
    <name>A0A1C1D0S4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine/threonine-protein kinase chk2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_00790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0S4"/>
    <dbReference type="STRING" id="86049.A0A1C1D0S4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00790"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01710"/>
    <dbReference type="eggNOG" id="KOG0615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22670">
        <property type="entry name" value="FHA_MEK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001380">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000841">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="190"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="281"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="626"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="641"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="693" mass="78346" checksum="C5494A9DF311349F" modified="2016-11-02" version="1">MSPKTERSSLKRNRRSTGDDQEIKKPRRSQRISSQSQKDSQQQTPLKNHYLPSPLTNHESTATEYKEHTATPPEGRPSQIRHVTPLASPALPQSSPPQDTQPLSQFIYPPRDIEPDLTDEDGTWGYLFPLTDNGHRLQMKRRAFCPAPARPLEVSRQTVKSKKRGKKDLLEAESEYEQGKNEKGFPAGGYLIGRHPECDMVLDIPTVSNRHCLIFNESRNGDMIAILEDLSSNGTFVNEALLGRNKRRELEDGDEITILDEARFVFRYPRNRDSSAFNSRYRILQQLGKGHFATVYLCVERSTGFKFAVKKFERRMGESQKSQTEGLEQEIAVLMSVSHPNVLCLKETFDELDGVYLVLELAAEGELFNLIVTKQKLTEAETRKVFIQLFQGTKYLHERNIVHRDIKPENILLTDKNLSVKLADFGLAKIIGEESFTTTLCGTPSYVAPEILENTRHRKYTRAVDVWSLGVVLYICLCGFPPFSDELYSRENPYTLAQQIKMGRFDYPSPYWDAIGDPALDLIDRMLTVDVEKRITIDQCLEHPWTRNAGYINPADSLDGLTGQMSAFDFSKRKIQRERTLLANINDIKVSKVVELNGGHPIQGQPSHIPGSPAHVKVWEKNPAGKNVMSSAGAKKTGKASKNEEGIAREEHPAANRQQAEFMGMGGKGDMQLFADDVTSRYLPEEVPKRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1G1</accession>
    <name>A0A1C1D1G1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GA4 desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1G1"/>
    <dbReference type="STRING" id="86049.A0A1C1D1G1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00854"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10136"/>
    <dbReference type="eggNOG" id="ENOG502SMV5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="338" mass="38462" checksum="6290EDFA9CB9164E" modified="2016-11-02" version="1">MAIKDSIFVDGTSAHVVSTTLRYWLDPSPGGYKAFYPGTVGVYRRKHDEQPAQITDVRGREKEFTLDKQGFAFVQHESKENDFADDEGVKDRLYPEVSELLKDVTGATHVRPFSHLIRSERWEDAQAAWEGKKDDDLVRTKVPARFAHVDHSYAGAVQIINDNLADEAERARLTANTRWAIINVWRPIHHPVTRDALTVCDARTVDESDLEGLTAQLPAPQNDKYGTVSLGRAFETWAVKANPAHRWYYKSGMTPDEALLLKIFDSKKDGRARRVPHTSFQCEEDHGPPRHSVEIRCLVFWEDQSLEIAKGEGVAQVIVNVERERTGEIQKMMTEMFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D207</accession>
    <name>A0A1C1D207_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_02713</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D207"/>
    <dbReference type="STRING" id="86049.A0A1C1D207"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02713"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04887"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04888"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="15">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1015"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1023"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT54792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1049" mass="116977" checksum="538F2C6B5B9534C8" modified="2016-11-02" version="1">MSPGRILEQDAYDFIVCGGGTAGCVVAGRLAEDNNARILVVEAGPHNKDLENVHMVGGWSKNFDSELDWNLVTPPMKGVDGRQVKLSRGRFLGGSSGVNGTLCVRGSKQDYDDWNLPGWSGEEFFEYMRKVCRIETSAETFHNKPWFKADEKAHGYNGPLHTEPHDLAPISDLLLKSMEDKGLPFVPDMFSNGETAHGSGHAIRTVHKGIRSTGADFVTNEYHRQNIDLVVETVVDKINFEERNGQLQAVSVVLVDKSGEKKTVQARKEIIVSGGAYCSPAILLRSGIGPKAELERLGIKCLVDAPGIVFAFYEVIKDGLTNDHLVYHGDAAMAAYMLYKEKKEGVLSTFPFGAFGFARLDERLKDDPLWQEAKREASRDPMGLTSKQPNVEFFTTELYGGPKQYDKYPIDKKHAFAMITELFSPRSKGTVTLKSADPLENPVVDCNYLSDPLDLLVLTEGCRLGNEIAMNVNKVAGEEVVKGSWPSDLTHHAYTKREDWIPYVKQEATTCYHAAGTCKMGRADDKMAVLDENLLVRGVKGLSVADTSIMPTLHGGHTQMPAYGIGEKAADLVRGRWTKARIQGPRIFKRLPLDFSKQSQSPARTRLASDGEGEADDDSIYTQWARVSPTSTIRRSFSGIQPTGVPHLGNYLGALRQWKQLHDQATNPKFSVDHHYEQYFSVVDLHALTSDVPGSERSRLRQESYASLLAIGLNNNTNTTLFFQSDVPQHASLMWILSTIASTGYLSRMTQWKSKLNLPENANLDSDEATAKLKLGLFSYPVLQAADILLYQPSIVPVGEDQLQHIEFTRTLARGFNAHVNQKIFRLPWPVISPAKRIMSLKRPEHKMSKSDPDPKSRVLITDSPEEIHAKIRGAVTDSEPGISFDPERRPGVSNLVEILKHVTQSREPSEFIAKDNADLSMRAFKELIADEIIAALRGVRERFLELMADKNEYRLRDEIENGGAKARRKARLTMGDVSQALGLTNLVLTPEEAARIRERRLEIERRELGAGLDLEFNPFENEGQDSEDEFGDEEADEERDKKSTRRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2K5</accession>
    <name>A0A1C1D2K5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ipi1</name>
        <name evidence="9" type="ORF">CLCR_03010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2K5"/>
    <dbReference type="STRING" id="86049.A0A1C1D2K5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03010"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05096"/>
    <dbReference type="eggNOG" id="KOG2149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="8">
        <location>
            <begin position="130"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT55002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="324" mass="35508" checksum="28E950AD02C8FE0A" modified="2016-11-02" version="1">MGSSAKKKREKKKDFQKQKLKVGKTRPKADNHTDTSFRAKAIVLNQQLDVAAPTQSAVFLHQVSLLNSRSDVQRKDALAHLTNYIAASSSEEALPITTSSLLGSIFPLILDGSSGVRNQLLKLLHALPQEDVRDHVSRALPYVRAGMTHLSRDVRATAIDFLSFLIRIAGTELVSCPGGWHQTLECFTTVLGWRSASSKASFAGDVRSTARILNVLSDFLQAGLLTDKLSSSEPNSLVTAFPLWRVETLLVPTKSSAYAHLNLFGPQAEDDSQILDEQEDRLQNFTRHFRDPVLAGIEAARKEGGELGRAAGLVVKTLERAQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D307</accession>
    <name>A0A1C1D307_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_03014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D307"/>
    <dbReference type="STRING" id="86049.A0A1C1D307"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03014"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05130"/>
    <dbReference type="eggNOG" id="ENOG502SMMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF9">
        <property type="entry name" value="FAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="230"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT55038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="331" mass="36478" checksum="A5A7717B3EA70FE2" modified="2016-11-02" version="1">MDNTDPSHRKAIIGHPSSTFWLYDSKTGFDLTHPPTPTSATPTPNYTIKTNTLPITIHPPKSALVIIDMQNFFLSPQLGRPRDSKGLLAQQQLLKYAIPAARKAGVRIIWLNWGLTQQEIDEMPPATLRAFGFETVLASEWESYEKVEKKQAAIDSHGVNEGCHKFPDPQIETSGKNPRIYRGLGQEIGPVTIDDGGSSVQGGRLLMRDTWNADLPPELKQSYEEEGKKANPPDVWIHKNRMSGLWGERTDCTDFLDREGIKTLFFAGVNTDQCVGGSLQDAFSRGYDSVLLSDGAGTTSPSSSQESIEFNSAKTWGFCVSCKDFAEGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6Z3</accession>
    <name>A0A1C1C6Z3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6Z3"/>
    <dbReference type="STRING" id="86049.A0A1C1C6Z3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06049"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07002"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012746155" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="114"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="280" mass="29081" checksum="0F6C1A8BBD13DD3F" modified="2016-11-02" version="1">MRAWNVFLVATGATAQSVSYIYTATFTETALAFVSFTTCPCPTSTPGLSSFLTTTTPAPVTTTSYAGPLLPSDTVAPSSPIPTFTTSPVAPPSGSVPPSSTASSSGIPVVTNDAYIATVLRHHNIHRTNHSADPMVWNTNMANIAREIAETCVYGHVTSVGGGGYGQNIGAGYPATPLGMGNFITEGLYNDEVNNYVYYGMEPNVTTLNQWGHFSQIVWKGSSSVGCYTADCSSGGLTNAGPPIPPYFTVCNYSPAGNVLGSFASNVGVSIGMATVHGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C798</accession>
    <name>A0A1C1C798_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_05964</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C798"/>
    <dbReference type="STRING" id="86049.A0A1C1C798"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05964"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07097"/>
    <dbReference type="eggNOG" id="KOG1620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF103">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT44403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="386" mass="42171" checksum="4F88AA4C307E4F28" modified="2016-11-02" version="1">MATPQASHASKKVAVTPNESELVPFDHSAAGHEGISSNASGSLIIKPCTQAEIDFYESAKDHPLFQAHMPTFIGSLSQHEDQDAVAPLLEASHHGVAAPAGVIADPTPGLIKRATWKPSGGKKLSTGTAIVLENVASGFKHPNVLDVKLGSRLWDDEAPLAKRRKLDEVAEGTTSGSLGFRVAGMKIWAGITTPEDHAKVAPAEKEYVEVKNGYKSYNKFYGQSFKAENVVDAFTAYFGGAEESDGDKKVKFRQKRAEFIVRRFIRELESIQYVLENEESRMYSASVLMVYEGDEEALEESIAREEKEDGKAAAAGHEDGVGDEDVNEDEDDDDDDDDEQDTKPHKIHEVRLIDFAHARWTPGEGPDENALKGIRSVLGVLRNLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7H3</accession>
    <name>A0A1C1C7H3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_05778</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7H3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05778"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07167"/>
    <dbReference type="eggNOG" id="ENOG502QQA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="65"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT44485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="498" mass="53287" checksum="E6987200A3D5E34E" modified="2016-11-02" version="1">MRINNSSSGGSSTVVLEMPSRSQQPNNSEKDVPVYEDVSAGALPSPTTATPQLQKWNSPRINLWRCLATFYSFIILGANDAAYGALIPYLETYYHVNYTIISLVFLSPIVGYTMSALLNNHIHTVYGQRGVAILMSVSHVCAYTAISVHPPYPVLVIVFILAGFGNGLGDSGWAELRDRNAWIGDMANANEVLGFLHGFYGLGAALSPLIATTLVTKADWHWYEFYYLMVGAAVLEVILLVGTFWKADAQAYHAEHPRTADTDSSGSSTPTGIEATSNGEGAAKKQGLLGKLSPFGKRGKGKSKTAEAVKNKVTILASVFLLIYVGIEVSIGGWIVTFMLRVRKGKPFASGLTSMGFWLGITVGRLVLGFVTARLFKSEKHAVATYLVCSVALQLLFWLIPNFVVSAVMVGFLGFFLAPLFPAAVVALTKLLPKRLHVAAVGFAAAFGASGACVLPFAVGAIANAAGVKVLQPIILAALVLCLGVWLLIPTLPKQRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7R5</accession>
    <name>A0A1C1C7R5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7R5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06298"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07198"/>
    <dbReference type="eggNOG" id="ENOG502S4D6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650660" evidence="2">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="199" mass="23444" checksum="A410FD76A277E608" modified="2016-11-02" version="1">MKSINAALLALIAVTSAHGVHPDERVNPADDWALYHMQEEHHISNFDPASFFSLHDFNNDGSWTPDEVRRIYGLDDESLKDTPADQKDKAVFDVFKIFDPYQSGVITRDQWTKKINEGKKLPDFGLGPGHHGDDEYEYEIHHFEKYHDENTREEDLIHPEDIEHFRKHDLLEDQADRIFREQQQTIVERNIPRKFLRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C872</accession>
    <name>A0A1C1C872_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C872"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06063"/>
    <dbReference type="OrthoDB" id="10672278at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT44743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="347" mass="39705" checksum="0824260D1ABF3DEC" modified="2016-11-02" version="1">MPTLLELPTEIQAMIVRLVFEQYTVVPVKKSTRQSTRLRLKREATDLGNPVQALEHTSHRTDLPAPVLAPFDPFSFFHVCQTLYKNKLLKAVALMRMTVMVAEDTFVEVVNAGRQLSHRKEARLIGSMRLAYTARYPIPSPSRMTQLFPSLMKFTIEGQRSMFFSARKAASELDAAFKSAQKARRNIIVYPVEFVIHDRNIHSDQKETMEKRFALDYFLRKGCLVRFEFAPCANLLSNCSRPWKCAPAGPLPLPSAENEAAPFSRRLWLNVHVWITFISRQHDDFEKWRGKISTSGVRLELNTCCIKAEAVSKPVAFPTYIPKPSRGSNGTRKPIQHQVIRKFQRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9T7</accession>
    <name>A0A1C1C9T7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9T7"/>
    <dbReference type="STRING" id="86049.A0A1C1C9T7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06490"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07890"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="79" mass="8902" checksum="6B23CCDA2D992002" modified="2016-11-02" version="1">MDDMLVLFTGTIDEEYLLGTKVEGSEQQTELGVKFTREGGFYKELTTPNMGHLFWNNVIPGITDHDTGGTKFLQSFPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAT0</accession>
    <name>A0A1C1CAT0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_01660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAT0"/>
    <dbReference type="STRING" id="86049.A0A1C1CAT0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01660"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03488"/>
    <dbReference type="eggNOG" id="ENOG502RYP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF51">
        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="310" mass="35296" checksum="5F01DF6BCEDFDCDB" modified="2016-11-02" version="1">MPVTEIYILRHGHRLAWSLNPATGKYSSSHPFPTRLPADPPLASHGVRQAQETGRHLSALFADLVKQDRLRIYSSLFYRCLETLRPTVEALLEQIPEQDVERRRNLRVRGERGLGEWFGRAWFVQPSPADAARLRRDFFPWLNDEYTSRVIPSEHGERIEELHDRVARALASVVRDVDEEFTRQGRGDEEVTILISGHAAPIIASGRALTGDVPDDWDEEDFRCYTCGLSKFVRRQLPPAEEGERQAHYDDRAQGVAGGWDCILNSDCSHLSQGEERGWHFHGDESFDSYQTVQVRGLKVSDGSVHESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBV8</accession>
    <name>A0A1C1CBV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_00416</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBV8"/>
    <dbReference type="STRING" id="86049.A0A1C1CBV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00416"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10008"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="560" mass="62891" checksum="139BE4F5DFBBFC0E" modified="2016-11-02" version="1">MALGILEAKVEHVPGTVYVYETEQRHTQLLENAQHLKKDKAGRFILVPQPSNDPNDPLNWPLWQRDVILGILCFVSCLATTASPLLAADSVTLAIVFRRTFQDAALLTAYHLCGVCVAGWLFVASARVWGKRHLFLFGALLMIASSAWGGSEHVRHNYASLLWSRVFQGVALAPFEALVNACVGDLYYVHERGIRMAITNTCLFGGAFLTPVFVGMISAHMGWQWSSEGLLTKHYQFFFLAIFMALGFLLLFFFVPETAFRRAHSLDLDLLADGDSASDAVGPAQISIAKDEEKSLHSQRAAENVPRMDSYLKRLLPFNGRKTDESFFKLLFRPFPLFLHPAVIWACLIQGVIIGWTVMVGVILSLIFLGPPLFFNEEKAGKMYTSAFIGSILGLFGAGTYSEVVTRFLTRLNKGKYEPEFRILLVLPTLVFSCIGLYGFGITANDVARYGWIVPEVFLAFIIISMVMGSIASAQYLLDAHRDIAVEAFTNLIIFKNIFSFILAYHAYNWVFAIRINHLFIIFGSIEIAVCLLSIPMYVFGKRNRELFHRHDLLKMARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC02</accession>
    <name>A0A1C1CC02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC02"/>
    <dbReference type="STRING" id="86049.A0A1C1CC02"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00443"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09981"/>
    <dbReference type="eggNOG" id="ENOG502QQGR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="22"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="406" mass="44049" checksum="E4A27C6E23D64DC0" modified="2016-11-02" version="1">MVLSSESVNNIKTTLNAACDDANKGLPGVVAVAIGKDGKELFAHAAGKRGFGSKEPMTLENIFWIASCTKMITGVACMQLVEQGRLSLDDAEQVASLCPEIKNLSVLQADGKLVPAKKGVTLRMLLAHTAGFGYTFFNEGLRDHSKPVGYDEFSGHIKDLVQPLVHQPGEGWEYGVNIDWAGICVERATNMPLNNYFQRHIFQPLGLKNISMFPNAQMKAKLAYMNARTPDGQLHPRDHLLHRPLVVESEQDIATCVNSGGAGAFALPREYCQILATLLNDGTSPITGAQILKKETVDLMFQNQIPEFPNFGRQGIPPAKADLTNAIPDLYPGKEQGWGLTFMLSDGPTGRSTGTAHWAGLPNLYWWCDRAKGVAGIICSQVLPFADPQVLGLWVNLESGVYGGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCB8</accession>
    <name>A0A1C1CCB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_01319</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCB8"/>
    <dbReference type="STRING" id="86049.A0A1C1CCB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01319"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09366"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT46155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="217" mass="23397" checksum="124EF606DBFF4721" modified="2016-11-02" version="1">MSVAISLAELASVYPTAGGQYNFASILTPKKIRRGVSYACGLLSIFSWVAIGAAVTIIPAQQIMALVSASNPTFETKQWHIFLLYEGVAAFILVNNLFLLEKAPWTHNIGCMCADITQLPHEPETNSYLVALTLSMFLFALITLLARASPKASSKFFWATLINYTGWPDGLCLIIGLPTSCFMYIGLDASMGCFVCSLSCMMLILGGEGTRAAASTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCF0</accession>
    <name>A0A1C1CCF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Nitrite reductase [NAD(P)H]</fullName>
            <ecNumber evidence="19">1.7.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">niiA</name>
        <name evidence="23" type="ORF">CLCR_01049</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>NH4(+) + 3 NAD(+) + 2 H2O = nitrite + 3 NADH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NH4(+) + 3 NADP(+) + 2 H2O = nitrite + 3 NADPH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.4" evidence="19"/>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCF0"/>
    <dbReference type="STRING" id="86049.A0A1C1CCF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01049"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09318"/>
    <dbReference type="eggNOG" id="KOG1336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432169at2759"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015980">
        <property type="term" value="P:energy derivation by oxidation of organic compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd19944">
        <property type="entry name" value="NirB_Fer2_BFD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000007">
        <property type="entry name" value="Nitrite reductase [NAD(P)H] large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1100:FF:000002">
        <property type="entry name" value="Nitrite reductase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="entry name" value="BFD-like [2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052034">
        <property type="entry name" value="NasD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809:SF1">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="22">
        <location>
            <begin position="935"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="891"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="895"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OCT46204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1133" mass="124300" checksum="D137A3CD2A7ACEDC" modified="2016-11-02" version="1">MSWATSSPGMAISRAPKDAEASGDQKPSEGQRKKVVVVGLGMVGIAFVEKLLKLDAKRREYDVVVIGEEPHLAYNRVGLTSFFQHRQVESLYLNPEEWYKGHPTDALNYHLNTLATEIKTSEKVVITANGDTIAYDILVLATGSDALLPRHTPGHDAKGVFVYRTIDDLQKLIEFSATVKGTTGCVVGGGLLGLEAAKAMMDLEEFGQVKLVERNRWVLSRQLDGDAGGMVVELVRNLGLDVMLSKRVGKILANEDNAVKGVVFEDGEEMECSCIMFAIGIKARDELARKAGLKCADRGGGVTIDNNLRTSDPNIYAIGECASWENQTFGLIAPGIEQADVLSFNLTQAKVHSARTFKRPDLSTKLKLLGVEVASFGDFFADRDGPKDLPARHVKRAERAQKGTDATQDKVKSLTDGPAPPAVKALTYRDPFAAVYKKYLFTVDGKYLLGGMMIGDTKDYVKLVPMVKNKKQLEVPPSEFIIGASKDGDENADDLSADTQICSCHNVTKGDVAGVVKDGSCKSLGDVKSCTKAGTGCGGCVPLVQSIFNKTMKEMGEEISNNICPHFKYSRADLYHIVYVKKLKDFGEVMRDSGTDPDSLGCEVCKPAVASILSGMFNKHVMDKPLHGLQDTNDKYLGNIQRNGTFSVIPRVAGGEISPEKLIVIGQVAKKYGLYTKITGGQRIDMFGAKKQDLLNIWSELVAGGLESGHAYAKSLRTVKSCVGTTWCRFGIGDSVGMAIRLEERYKSIRSPHKMKGGVSGCVRECAEAQNKDFGLIATEKGFNIFVGGNGGATPRHSEVLAKDVPPDDVIPILDRYLMFYIRTADRLQRTARWVENLPGGIKYLREVILEDKLGICAELEKQMQELVGTFFCEWTEVLNDPDKRRSFQQFANSEENREPAVEKVEERGQSRPAYWAKDPVHDDFKGTRWTSLTWQPIVEAKRFQDLDTGSSQTVLRGDTQLAVFKLKGKYYASQQMCPHRRTFGLADGLIGEIKGSDSSNNDCKESKFYVSCPYHKRNFQLNGDVDFEDKAAGAGSCSNDTSMSIATFAAEERDDGWVYLKLPPVQEMDNVLGTTKWAVKAGETPNPFASLDKKLGLKNGLRPQKTVGAMPGTGNVNAGREISVAAQRRIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCK8</accession>
    <name>A0A1C1CCK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_01046</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCK8"/>
    <dbReference type="STRING" id="86049.A0A1C1CCK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01046"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09326"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09327"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="265"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="4">
        <location>
            <begin position="596"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1093"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1119" mass="126242" checksum="3D5B18A5AFEC67E1" modified="2016-11-02" version="1">MDPVTALGVACNIVTLVEPGIEAAAVCKELYKRGSLDENNNIERYADGLTAANNELQAVLKPHATTRASRLQQIAQDASKIAADLKTELNKLKLSKSIGNRQTGSAFKTTLKTMFKRGTIDKLLKALEKQESALQSGLLKELYIKAGQDDLARRKEFKALDQAWRDTIVQILGRLQLASTDIETSIKATGASITGRLDNHHSAQTSYLRDQQLDGLRVRLLDALAFPEMNERRNMIEQRVSDFGSTYGWVLGQPDKRFFNPFRSDDHEFVEWLRNGKELFWVSGKPGSGKSSLMDFIYQNIHARGSAFDMLAEWARPMPVQVLTFWFFRPASSVLLKSLQGMWRSLCFQMLEQNEKLVETIRTDDDGLAPASLKSCLTMSGSRARTWTDTELRSWFEYLITHSEYKYCILVDGLDEVASDHEALLHDVRYIVSISKTVKICCSSRPEPVFKRTLCNYPSLRLQDFNHNDIRMHCQERLEQTRAAKFATRIADMADGVFLWAALVAGDLKNAAGKGDSEEDLELRLEGCPTGMNDLFTFLLEKQDTFYAKHPEPYLALIHAATKAHLDITSFELLLASSGREQLKEFFESGLNDSRLAALDTLVSNMEVNIVARCANLVETGRDTSENLSPKFPAEFSYESLDKARTTTIRFIHRSAQDFLVESEKGAALLQSCGIAEQDAVKLLMLSSAVISAIDLSDVSAEKMSVCGSNIQRDFWTPYETYVADSVFASVQVRIPRGIPWNSAEPADGQQRTHDYNPEHLGLFCPQISVQQNVALHYAVYYGMVAYLNSKLVSHGSSVSSELVSFCLIQWIYKGRDSRDDLIRVLKKRLSWKQSLTVCYKLADIPETVFSPPISLPLWQHMYIAVTRSYLETNPAERPPSLHSSLGHIPVSDPGNPYVESIIFFKEWDIYMCPTTSESMVSVEGSLCSYHVFKLRVKVDESTGAGLISLDFRQYSPAGLTRFFEIDPTINHALQGLFHTTAMWGAYNGCTKFLVSILNQNLDRLAAVEIAQILTLPSPSPWESLQVCRNVIFSEGEFRFVDQDSRKAWEDQLKLRRGGIHGDEIFEDDTEPDRGGWPDSVLSEIVKAFEPKRRRDELQKEKSCQDEEGMENERRHVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCQ0</accession>
    <name>A0A1C1CCQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative SWI-SNF complex subunit (Snf5)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_01090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCQ0"/>
    <dbReference type="STRING" id="86049.A0A1C1CCQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01090"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09272"/>
    <dbReference type="eggNOG" id="KOG1649">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT46248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="743" mass="83490" checksum="7F7BE473DE788C05" modified="2016-11-02" version="1">MSNTPDGATAAVTAPAEASAQPHSNDETIAQGKERAKEVLAASGIDVTRKDSTTETNGRDASPGATRKRKRETPIDRIQAAEYVDREYHYKALYAEQLAHPVISQQKKQELALYQSLRQRREHDPGSIFGYGYEGFGNPRTDDRTIRDPVLYPRQRRLGKRKTLPPRVSRKDQNIQAEQSEELVPIRLDIEWGKIKLRDTFTWNLHDRTTSIDYFAEKVVEDFGLEVQNCRPLTQSIANHIREQLNDYCPQIYADDEPWEPSLPYFAYKNDEMRILVKLNITIGQNTLIDQFEWEINNPFNSPEEFARQMTSDLSLAGEFTTAIAHSIREQCQLFSKSLHITGHPFDGRPIDDPDLRENFLPSPLPTTFRPYQAAKDYTPYLYELNEADLERTELSISREQRRQKRSTNRRGGPALPDLKDRQRTIRSLVVSSVIPGAALTTEESRIFRMPKATRKSVRGQRDGFEDSDESDSDDSAPDSPAIPAHLLQGGTARTRGIRNAALTATAGIRSNLSGFASVRSATPESIAPLHHEGRASARKRDYKEESDDESTPEKLIVVLKVGKTKMREWMRSQRLRDRAAHMSNLSNASSPRPGTHSRSVSAAPLNLVGMPPPPSPAMAPSSASTDIPGAVDATANPTTPAPPPPEWLVQDLQRLRKIYPNDRFEALMKHTAVDPATQKLVTPSEATRSFPHKYVPRIRCSDCLGKVYLPGEGLTATNFESHLKNRNHRSHVEARTAKKEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCQ3</accession>
    <name>A0A1C1CCQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01364"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="75" mass="8593" checksum="D751E24AB52B8E49" modified="2016-11-02" version="1">MEVGTIDEIRLRMQENKDNMDENHNTLLYPAVRKPLKQRQRERPLPAMSTASSPPPRDTDRHPQVQRGGLQSCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD96</accession>
    <name>A0A1C1CD96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD96"/>
    <dbReference type="STRING" id="86049.A0A1C1CD96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01204"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09100"/>
    <dbReference type="eggNOG" id="ENOG502RZH4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10050400at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="48833" checksum="4740355213289F6B" modified="2016-11-02" version="1">MATKSGVLTMQLLGSFKPARASSSRTFVNGFHSFPKNRPRIRGMPTLNTRFQTRNARRYPRPPNRLEQAVIDARLQHPILFPFMLFGSTASVVLLIIMAYDQWRRENKGTSAYPPAVEDQLRLALHYTHISPDPETASQYFLGAIKKAEEVGMDPYSKETLGIRVRFSQMLEEFGHVKAAIEILDGIANDLQQKLDELDQALSLRTDTAIQSGPESANLRANMIKGIVRLKVKISSLYESDYLQNSSMAKQVLSDAVGMVVKETKNPQQGLTDDNGAGLTAGEIAAMLSQMGDLYATSGEEENAVQLYMLTLQPLRASCNGTRSCKEAQVLSNIASTMDMALKKPKPLINGKPATKDSLAAARRAALRWADQAIATGDAVKPEDRDEICAAASLSAKMTRADLLVDNGEKAMAKEAFLNLLPVLREHNLLPLIETAEQGLKKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDD1</accession>
    <name>A0A1C1CDD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED5</name>
        <name evidence="10" type="ORF">CLCR_01804</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDD1"/>
    <dbReference type="STRING" id="86049.A0A1C1CDD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01804"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01192"/>
    <dbReference type="eggNOG" id="ENOG502R1HB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5322661at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT46458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="963" mass="104793" checksum="4A89862AE6D24B30" modified="2016-11-02" version="1">MDATVAGMSWRQSHGVAGFDEALKIAGKARSDGKVMIWRLNFGDLLQAHDGEIPMRRLFDALVDCRESFCPPGDPLISLYIDHLGSTGSISVSDALLVLTKRWNNAKGQLSQDVLACCNQTVQDLTMIMIAPKYKLEASEARVALSLSSRWLSALARQASREDGERTGLEYSATVESLAFLVVSLAATDAGLEALSPSVTSKKEGLDGPLKDLRASMRQALELCLPLYSVLSSQLVERINTVLKHISLLDGGPPQDSNTSTQASEIQALQFQVSIAESQLVASKAGTTLFLASLLLTGSTVDDGTAVNWLSSRHHNDYQAMFSDIFTTSFAILKCQNSTPRRSLCMQQCQIFIQNKLPALLSMISATSFNGFSTEQAISDAWQQVVPLLSEHDLLLIGAHFLHVCSLIRLLPGQMVSQLVGNEELLKGLSKGLYTKDGLVDRVNSNPARGPKLVEELIRGDGSAGFISQAIVEIMHNSCQSKETQYLKDLANAILRKPAAINCIALFIRPSFFLSPLCSLLDEWRWDEIHGEAQPVYDDFGAIFLLILVTKARLDLPNSELGIRKKGGFLSEYLRHENYEHSLVDLSEEKRAHLGNWINALYLAEGLSDELFTSCSPHDFYLLIPTLLRQSVTAYQQGKLTHDALKAGLDYLLEPFLLPSLISALGWAGEVFHQDSAVVGKVLDVLTKAPGTTESRDIHHTILAMCAPRLKLRLTASASKDSNIGSVLKTLDKCQDFTLSAEREVQNGGPGVVSLLQHSLVTLITSANTAHLEHQVGLHDIPALVSRTVEIRGAEAALRALIGVLLQLSDSHQFLFALDAVTTVVCMGGEGLHDALRLLYHNLGGTLRSGDTLSAEAVVRLYRQVEAYKNLLTVQDMGLDTIFGQQLINIDTANPNLDAATAVSGGVGDVQAEQGQPDGIDQVLDEVAAMGNLDTSDADMNFDTLYGLEGNEMDLNDLDLDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDJ6</accession>
    <name>A0A1C1CDJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5-Methylcytosine G/T mismatch-specific DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_01960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDJ6"/>
    <dbReference type="STRING" id="86049.A0A1C1CDJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01960"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01333"/>
    <dbReference type="eggNOG" id="KOG4161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265068at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF0">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="4">
        <location>
            <begin position="225"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="466" mass="52245" checksum="00B557B40D08C29B" modified="2016-11-02" version="1">MSSKHGGPSPPPSPFSRLELPVVPTDDLGMVADDDNSRETAEAQPALKVIRERKAAGTRRKITYISRHFPTEKPKNDQQEVLPQKEDQQGGSKLKSNDASSVHQDDPSKTSTLPVIPGRPRIYYGLNIDELSSDSSLTDVPEDIGPDPFPPDVTLARFTTLVQAIKVKTKKVRVPTKSPYFVAAHKHRPTFLSTLPFPPLSHANFGLMQERLAHDPFRLLIATIFLNKTPGERAMPVFYQLMSRYPTPTDLANAEVSDVTSIIYELGFQNQRARKCVAMSKVWLEKPPERGKRYKKQNYPLKGDGRDVGNGEVLDDNDGRVAWEISHLPGLGPYSHDSWRMFCRDKLRNLAKNWNGEGAENPASFEPEWKRVVPLDKELRAWLTWMWLKEGWVWNKETGARTKASEELMSMASGGGIVVEEKDSDHLTVKTVAGDDLRSLKAQKKVESTAGDFLPGVSDTGRREVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE00</accession>
    <name>A0A1C1CE00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE00"/>
    <dbReference type="STRING" id="86049.A0A1C1CE00"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01992"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01401"/>
    <dbReference type="eggNOG" id="ENOG502RHGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3883941at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="407" mass="44867" checksum="45A8F2B5ACA902AA" modified="2016-11-02" version="1">MLARTPRAALRSTRVVKPCQPSRALQPRNVRFQSTAPANSSTNASSGSSHALVGGLAGGAFAFLLGYTWYSFSGVKTAVNSVHSTKSYVENAFKKTTENAPEPSQAVQWLKETVQSYTRLIPGASKYVDSAFQDIEKIQENHGDEVNQIINDTYGKLKDATNKGFSMEAAAQAWDILQDAFKRIGKLAGSAGQEIIDNHPQLKEQFGGRFQQLQQMGEQYGPEAKKVVDDTWNQARDILAGGVSFSTAQKLQQLIQEKTQQVQQFGDQAWQKGMEQAKPLLDKQPELKKLFEENKGKLLRGDLGQLWQKVQEATQSGNSEDLQKFVREQAQKASDGAGGGIEQFLQMIPGGTEIGPKLQQLQELSEKHGQEAERLIKSAIEDVKKVLSQKVEEGQKLKEKAKSDAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE16</accession>
    <name>A0A1C1CE16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="3 14">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SET1</name>
        <name evidence="17" type="ORF">CLCR_01791</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the COMPASS (Set1C) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the Set1C/COMPASS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="3 14"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE16"/>
    <dbReference type="STRING" id="86049.A0A1C1CE16"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01791"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01429"/>
    <dbReference type="eggNOG" id="KOG1080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017111">
        <property type="entry name" value="Set1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024636">
        <property type="entry name" value="SET_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11767">
        <property type="entry name" value="SET_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037104">
        <property type="entry name" value="Histone_H3-K4_mtfrase_Set1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51572">
        <property type="entry name" value="SAM_MT43_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 14" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 14 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="1134"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="129"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="386"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="658"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="739"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="790"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="868"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="940"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1067"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="658"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="750"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="794"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="868"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="892"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1067"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT46708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1260" mass="139873" checksum="5204FAD58649A587" modified="2016-11-02" version="1">MSRPQGTSSHSKLADFFPTAPSVIQQRKSSKLPDLDKPRLRRPDERAEDVNARENHLRHALNSSSATPHPPSPAKQHQPAKIEDADHYPGDLLNGVGSASSSSTASSVFSAALANAAMPGANHLNLSTLTPLTSSDSPPNGKLISPTGDSGSHTAMDSSKPASCLHQGSMTPLHTPPTHRRTARDCNSDVKGTKCTYDPELDKTLNSKDKRKLKPQFLDFGAKPEDNFQPPDPRLSIPNYTKAVVGKGKAKFRPAPYNLKSWVPDAATAVAPPPATTVVVTGFDPMAPLSQINALFSSFGEIEDLDNKTDPVTGRFLGICSIAYRDCASFQGGGPISAVLAAKTAYLEGKRGQRIGLKTVQIVIDRDGSVTERMVEKAIALHRKESGFTNQSRIQPSPSPAPTPVTVPSPAGFAKSTGPPPTAPKGPSGKPSLRPQSTFSSAFPIPAKPERPSKLVAPSVVGTATATSAATLVETTPIAETLKVPYIFIAHCYVPVMTTTIPHLKKRLRMYDWREVRCDETGYFITFEQSRNGQMEAKKVFHGCHMQPLFTYVMNLELHLNGNHKAISATDPAPLPTSVTPTGPVDFVYSKQAYRLRKEHDLDLEEEKRQRARDLDPSRAVVQLVIQELRDKLLEDVKTRIAAPILYNYLDPGRHAERRKALGLDDPEGTRRPAYGTEGSQTPDSRVGIGRRPLGSKNLNILSLPKIGKRPGAGGLIGYRDERKKAPPRQNVRSLFHQLSQFHDEEDSEDERRTSVTRDTEDLESRPPSRMSMTSVSDDDDELLRKATKRRLHAREESEMGDSVIKDEVDTSRQTAEDLIIAKLERNIYEMSPSSRKRKRLVKELEARKRQKADDELFGVAQNEFEREQSEDVKVETPIEATPDAESDATKVKKPKPKKKTKKQIREEQEALRQAQAEAEAAEVVDNVLEFAEEEEALAEAAEWRPEVEWGVSAEEPLPTVDDDEDIVPDLRGWQASLFDAEDLEYLAAAMKLMKAMDIGDPMAWAWKQERIRNLRSGAQPGALRTDPAIDGYYVPNQSGSARTEPIKKILESEKSKYLPHRIKVQKAREKREAEAKKDPGKAPVVELPKASSRGKRADDRRTVKDLDRQREMLQSIGEDADVLRFNQLQKRKKPVKFARSAIHNWGLYSLERIQASEMIIEYVGEKIRQEIADLREIKYTESGIGSSYLFRIDEGTVVDATKKGGIARFINHSCSPNCTAKIIRVGGTKRIVIYALRDIEKGEVQHWARERKETNKSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE37</accession>
    <name>A0A1C1CE37_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE37"/>
    <dbReference type="STRING" id="86049.A0A1C1CE37"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02175"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01513"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="77" mass="8036" checksum="1B6E9CCF646C7D52" modified="2016-11-02" version="1">MLATSAVRSTPLRAAARTIVRKTTTRAASSTSNEAASPPFWLTAGASTATVAAIGSVAWYYHLFGQDVYAMTPAEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEC8</accession>
    <name>A0A1C1CEC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="7">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">osm1</name>
        <name evidence="11" type="ORF">CLCR_02311</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEC8"/>
    <dbReference type="STRING" id="86049.A0A1C1CEC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02311"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02523"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="10">
        <location>
            <begin position="553"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="497"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT46885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="637" mass="69288" checksum="6A196E2567EA4A1B" modified="2016-11-02" version="1">MAPPRVIVVGGGLSGLSAAHTVYLNGGNILVLDKNNFFGGNSTKATSGINGALTRTQVDLGIQDSVKQFYEDTLKSARDKARPDLIRVLTYQSAAAVEWLQDVFNLDLTLVSRLGGHSFPRTHRGHDAKFPGMAITYALMQRMEELCESDPDRVQVIKKAKVTKLNKEGNVVTGVTYEYGGEEHSVDGVVILATGGYAADFGETSLLKKHRPDTFDLSSTNGTHATGDGHKMLMAIGANDIDMDKVQVHPTGLVDPKDPTSKWKFLAAEALRGEGGILLNSDGQRFCDDLGHRDYVSGKMWEEKEKGKWPIRLVLNSKASNVLDFHTRHYSGRGLMKKMSGKELAKEIGCGEAALDKQFKEYNAIAKGEKKDAWGKKYFHNMPLDLNDTFHVALMEPVLHFTMGGMEINDKAQVLNKEQKPFDALFACGELAGGVHGANRLGGSSLLGCVVYGRVAGNSASKYLLEKLTTEGGASGASNRLGQISLHIDPNAPGKISVEWNSGSAASSGPSVGTKETTQQAQRSAAPVMDGNKSQDPGKKKDTNDISNFKVPEKEYSLEEVAKHNKKDDLWIAVKGVVMDVTNWLDEHPGGPQALFSHMGKDATEEFEMLHDDEVIPKYAADIVIGRVKGQEVRLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF56</accession>
    <name>A0A1C1CF56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative acyl-CoA synthetase YngI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yngI</name>
        <name evidence="4" type="ORF">CLCR_02353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF56"/>
    <dbReference type="STRING" id="86049.A0A1C1CF56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02353"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02317"/>
    <dbReference type="eggNOG" id="KOG1177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF6">
        <property type="entry name" value="ACYL COA SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="283"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="401"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="524" mass="57475" checksum="C60AD03EB6A05BED" modified="2016-11-02" version="1">MAGNCEQYVSVFFACMRLGCILVILNNTYTASEALYALEFTECRILFVTPRIGHHDNGQLLRQLREKPGTIEEIIILRGPPSHFTAYATLLKTGAVESDEGLEAISKAFSCHDVCNLQFTSGTTGNPKAAMLTHHSLVNNSRFIGDRMALTDQDVLCCPPPLFHCFGLVLGLLAIITHGGKVVYPAETFDAIACLAAISEERCTALHGVPAMFDSIFSLPRPEDFDCSALRTGIIAGAPVPRHLMELMVNELGMTEFTSSYGMGFACHSAKAPLKTNVQYDAGLTEASPTCFNAFHNDPTELKLSTVGQVMPHAHAKIVDRHGRIVPVGERGELCIAGYQLQRGYWRNVDKTNEVMIRDADGVLWLHTGDEAVFHRDRTCTITGRFKDIIIRGGENIYPLEIESRLVEHEAIDRAVVVGVKHARYGEVVAAFLQRSSSTHAADQRGGRVGVAEETGPTAHRPSDENIREWVRLKLGRHKAPAHIFWLGEDGIPATVPLTGSGKVRKFELARLAGQLVTQGRPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFD3</accession>
    <name>A0A1C1CFD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFD3"/>
    <dbReference type="STRING" id="86049.A0A1C1CFD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02688"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02255"/>
    <dbReference type="OrthoDB" id="3004402at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="97" mass="10808" checksum="83F8C3CDBFE5FB3E" modified="2016-11-02" version="1">MGSLSVEDQTQSHANTPFGLQPSILTAKCHPLVEQVTEEVDAYFSEHWPFKDEKTRKKFLSQGIPRVTCLYCANALDDRIAFACKLITITFLTDGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFE1</accession>
    <name>A0A1C1CFE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-Ig-H3/fasciclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFE1"/>
    <dbReference type="STRING" id="86049.A0A1C1CFE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02415"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02213"/>
    <dbReference type="eggNOG" id="KOG1437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650832" evidence="2">
        <location>
            <begin position="20"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="21"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="168"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="432" mass="46028" checksum="E51CC9F80CF85F19" modified="2016-11-02" version="1">MKLYSTIFATLSVIACCLAADQDILTILKQQNDISTFIALLEQFDDLVDILNQGTFSVLIPNDQALAAFGNENPDLSNDTDALRALLEYHIANGTHPSATFGLQPLFVPTLLTNPDYTNVTGGQVVEITSLDNRSAVVSGVKAVSHVVEADIFYLGGLIHIIDSVLTIPISSPATITKAGLTDLVALLNKGGFLTPSSPAATIVNSLADLTIFGPNSSQFSASFTGWEGLSSTDLLSILQYSISQGPVRYSSTFQSNTQVPTLDGISATMTEQDGQFYVDASLITTKDYLTSNGVLQILDRPTTSINSHIEPRGASGGLSTAAAAGIGIAIGAIILGGALVVALYMRTKRRRRFAEFTGGQTGDPPPRYELDAKGFHESATDASEVPRSQVIEIHHPTPPRSPLEIDGHERSRISVTIQGAPPRHLGFQARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFF9</accession>
    <name>A0A1C1CFF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFF9"/>
    <dbReference type="STRING" id="86049.A0A1C1CFF9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02657"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02190"/>
    <dbReference type="eggNOG" id="ENOG502RIPH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3001700at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="124" mass="13741" checksum="26FD5D4422679FC1" modified="2016-11-02" version="1">MSNANSNPSQEPQSQSQQDQSPGYYASTKQWYNKQYESWMPWVEDKVLGWFGQNKTSYVAKGELDKTKITGDKNVDAIQDGINEGVTGQFKKGGLLEGVGDLTSKEVINRGERKGKNDKGGYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFQ2</accession>
    <name>A0A1C1CFQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_02366</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFQ2"/>
    <dbReference type="STRING" id="86049.A0A1C1CFQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02366"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02071"/>
    <dbReference type="eggNOG" id="KOG1304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF332">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="181"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="570" mass="62149" checksum="D703475A8FE5CAC2" modified="2016-11-02" version="1">MSDTPNSATDDSRAARVVADHLPDGYTADIDGVHAGDGGPRGPGESEPESSLKLQGGDIHRDLFKIPHRARLHQRAATFSHPNEISSDLENETTVAEQLAPGGFRRQFVRQKYGRFNPAAIPVTRNFVEFLSLYGSFAGEDLEDTDDDTSTLDDEEGRAAGERRPLLGRRRTTMAAKMGEAGTTKTFFTLLKAFIGTGIMFLPKAFNNGGILFSSMTLLTVSVVTTWAFHLLLQCRQVYQKSGYGELGQAIGGPRMRSIILASVTISQLGFVCAGTVFVAQNLHSFEVAISRGTAPLSTNILIALQLLALIPLAFIRNISKLGPAALLADVFILLGLAYIYWYDISSLVEDGLNPTVQLFNPQHYTLTIGSAIFTFEGIGLILPIQSSMQHPEKFEPLLWVIMLINTIIFTSIGALCYATFGEATKIEVISNFPQSSRLVNAVQFLYAIAVMAGTPVQLFPALRILEGKVFGRRSGKRDAFTKWKKNGFRTVLVVLCALIAILGSSNLDTFVALIGSICCVPLVYIYPPLLHYKGIAKTTREKTADVLLMILGIACMIYTATITIVSSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGR1</accession>
    <name>A0A1C1CGR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGR1"/>
    <dbReference type="STRING" id="86049.A0A1C1CGR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03680"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04653"/>
    <dbReference type="eggNOG" id="ENOG502SWUY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="235" mass="25736" checksum="76AD0AAD742AE27C" modified="2016-11-02" version="1">MGVQDCVRFDPDDYRSKVQGYDDQQLQKKEVVLIRTLYSSTAGVISGVVMAPGTGGASLIGSVAGGRVMQLVEHKLAVVRTELMRRGMPLHQKTTRDQAIPAATGSVAGAMGLFSGVEGHLVGTAAGAAANLVGVETQPLDRVQTAPNRPVDQESSSFQKLRRSLTETASSKARSLQYPFSSEDKVLFRQYDNILERKKTLEGRYQQLRVSTLGAAGEKWYWYVIDHHPCVRQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHJ3</accession>
    <name>A0A1C1CHJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein hob1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hob1</name>
        <name evidence="6" type="ORF">CLCR_04167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHJ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CHJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04167"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08103"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000189">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="314"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT47936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="373" mass="41679" checksum="8CD71576D668D035" modified="2016-11-02" version="1">MLNHQIEFSKAIQEIYKPISGRVSDPNSLIPEGNPEGIRACEEYEAIVRELQATLQPELEMIEQRVIAPADQLLEVIKIIRKINVKRDHKQLDYDRHRTTLKKLQDKKEKTLKDEKALFKAENDVEQATQDYEYFNNLLKDELPKLFALEAEFIRPLFQSFYYMQLNVFYTLHEKMQAINIGYFNLNLDIEEAFEMKRGDVQERAEALSIVHFKTAGGAKPRGVSKYASFGSKGKEAEANSSLKSPYGSRRTVNPEDGVANPPPPYSPSGSASAPHSPAIGSPAIGSPALGAAIAAKGKPPPPKPKPSRLSGVPAAETCTALYDYEAQAEGDLSFLTGEVIEIVHRTSNENEWWTGRVNGRQGQFPGNYVRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHQ5</accession>
    <name>A0A1C1CHQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_04292</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHQ5"/>
    <dbReference type="STRING" id="86049.A0A1C1CHQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04292"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08158"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT47992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="289" mass="32071" checksum="FDC02501FF80C55D" modified="2016-11-02" version="1">MHLFLIRHGETEHNVAGLLAGVSDSRLTNHGVLQTQRLGRYLTSHRNLRFTQIYASDLQRAFMTANELQRHQALRYPVVQVPVVVQLELLREQDFGSLELVPWSSRRAQNTSNSSVAGPTDPSFRPQETAEAMSDRAEAFLADFILPLFAAANDTSSPAQECVAVVSHGLFLSVLWQSLLRKFDAGRVVLGPNIEVPSYSRPLEYLPSWANTGFLEVTIDSRIDDITAAISRPAMKDQVLSPLSGFSMTVHSVNSKDHLLDLKRARGGLGSVAYDAKQQSLDGFFQRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIP8</accession>
    <name>A0A1C1CIP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03992"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08514"/>
    <dbReference type="eggNOG" id="ENOG502T6NH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4160615at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="506" mass="56334" checksum="CE81714AE41D8EA1" modified="2016-11-02" version="1">MATTEPPDGLYAEESNAEAEVDTDETPTSPHIPDLSTVPGNGLRKLSEVNIVATERYGDLYAPIFRQLQIRPDKYYDFHNGVIRVVRRKQQAEIRRATGASIKTTTDYLLRAFGYIVWTPNSEWLLDEKDLDEGEARLVYGKNKAVDPRYHPVCESLWRQMRNVQFTRRATPHRGQSSSDATPVMADGDESYLGDIDSGHPSPHSRARATAMKKIEDLSAEVARRLPAPSRMNADQTEEAIIELITRLATIRANSDPKIFEELWQAHIMRVEELEEEVAHRGEPIANLAAENLHSAVTGNQQDATSPSNEPFNTSGLPLAHSYPSTLAIAPALPSIMSVYISMAQVASPIRNPAPSTAAAPMTPAYHWPSAPVENHHFVNFFTGINYRVDVPSARILGRVQGEMAGNTADVRAHEGNENAGRVHQEVERAKDMIDVNTPASATTTPTFAPNPAKSKEPEDFTIPEWQTMALGWRDFQNDLRYAAQSGVRVWRMKVCVITMHARDMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIS3</accession>
    <name>A0A1C1CIS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIS3"/>
    <dbReference type="STRING" id="86049.A0A1C1CIS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04135"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08512"/>
    <dbReference type="eggNOG" id="KOG1430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="414" mass="46075" checksum="123449818CCB1643" modified="2016-11-02" version="1">MATPDGAVEVNGTHKPSVLIVGGLGYIGRFLAKYIHTQNLASSIRLVDKVLPQLAHLAPEFNEACSQDKFIQADASRDTSMARVFDHPDGPDASWDYVFNCAGETALSQPSEIYKLRSWQVSVTLAKEAAKRHVKCFVEVSTGMVYAPNRTPRTEQDKLKPWLKLAKAKLEAEQELSRVPGLNLVILRLAHVYGEYDSKFIAKALCLARVYQEQQKELKWLWTEDLRINTVHVEDVARALWAAAEWRAKNAVIPPSLLSSSSSSSSSPTLPRRPTLSKGEDGPSGNVPVFNIVDHGQTSQGQLADIISKVFDIRTGFQGTIISQFAKMNLEHVVDDLNEDLLQPWADMLEKNGITKPGPLTPFLEKELLKDTDLSLDGSLFERVVGFQYDRPDGLTVQGIKDMIASYEKMGWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ03</accession>
    <name>A0A1C1CJ03_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl22</name>
        <name evidence="5" type="ORF">CLCR_04256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ03"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ03"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04256"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08612"/>
    <dbReference type="eggNOG" id="KOG3434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT48488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="138" mass="15411" checksum="00E5F540B1C5C062" modified="2016-11-02" version="1">MSAVKARGTAQKAAAPSKGGKAVKGAKVTNKYTINCSQPVSDKIFDLSAFEKFLHDRIKVEGRTGNLGDNIDIKQVGDGKIEVVTHIPFSGRYLKYLTKKFLKKQQLRDWLRVVSTSKGVYELRFFNVVNDEGDEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJN5</accession>
    <name>A0A1C1CJN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05237"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03170"/>
    <dbReference type="OrthoDB" id="4160889at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="120" mass="12707" checksum="F90458486AB491D2" modified="2016-11-02" version="1">MANSSTDDKIAYILTVLKHTTLPKPDYTAVAVESGINTAQNAQRRLKAIVKAAGFDLVNDQIVGPDCSTGDGTGIAASPPKKRKPRAKKAAGEESNKKPKVKKEEDVEAEMNQGGEESVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJR2</accession>
    <name>A0A1C1CJR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="7">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_04557</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 7">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJR2"/>
    <dbReference type="STRING" id="86049.A0A1C1CJR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04557"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03183"/>
    <dbReference type="eggNOG" id="KOG2303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT48717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="700" mass="78137" checksum="38152273E6803780" modified="2016-11-02" version="1">MPFITVASATLPSVPLDFRGNLQRILESIRVAKSEGAKLRTGPELEIPGYGCLDHHLESDTFFHSWEVVAEILNDPICKDMLVDVGMGVRHRNVRYNCRILLTYKKIFLIRPKMSLANDGLYREARHFTAWVKERTTETYYLEKVISDITGQATVPIGDAVLSTLDTSVGCETCEELFTPSNPSTNMGLNGVEVIVNSLIQNCTRKLGGIYVYANATGVDGEARMMFDGSSMILCNGRVLKQSTQFSLKPVEVITATIDLEEVRSYRSSISRNVQAAAQPEYPRIECNLSLSRPADEIFFSQTLKLSRGVPLKILDPMEEIYMAEAVFLWQYLTRANAGGYFLALSGGLDSATVALFVFAMANVVLQSINAGEDNTLADLRRITGEKDLTVSTPQEIVQRLLHTSFMGTQHSGDETRSRSKRLASSIGAYHSDINIDETVTAHENIVQKALDFKPRFQVEGGTAAENLAKQNIQARNRMVIAYEMAQLSTLARKKPRAGASLLVLSSANVDEALRGYLTKYDCSSGDIAPLGSISKSDARAFLAWAREKWNMPLISEFIDARPSAELTPLSAGVQDDESENEMGLTYDELSTFGVLRKVEKLGPWSCYLRLLVEWQDLGYGPLQVATKVQRFFRFYAMNRHKSTVLTPAVHMSAYNPDDNRHDLRPFLYVIDWPWQFNKIREHADALAKTLRNRSGGESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKI6</accession>
    <name>A0A1C1CKI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="1">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ubp16</name>
        <name evidence="5" type="ORF">CLCR_04743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKI6"/>
    <dbReference type="STRING" id="86049.A0A1C1CKI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04743"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02884"/>
    <dbReference type="eggNOG" id="ENOG502QSIQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF904">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="49"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT49028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="577" mass="64013" checksum="12027274064E2B2C" modified="2016-11-02" version="1">MPDKPTTVVAYAAGASLAAIAAFYVFGPTFFIDGENSYNTNDGRKRTIIGLSNPANDCFINSVLQALAGLGDLRLYLIKELHKKQLDGPEVYDSVPPVLRKGERADKIVGLQKGPVTKALKDMLDALNERPIYKKTISARPMIEALERAFNTRISRNQQDAQEFLQIVLERLCDEYHAAQRARLRSENPDHTEETDITDSKPSGSTRALTEVTVGTSEGFPFEGRIESQIQCQRCGFRTKPTATTFVSLTLNVPQKSSTSLDNCFDILLKSEEIDDFKCDKCRLQHALDWKNKKLASAKTEKDRKELENEIALVEQAIRDDPEKAPEGITLPDSSLAPKSKIKKSTRITVFPKVIAIHLSRSVFDPGNYSTKNMAKVSYTQRLRLGGLLNEHWYKLLGVVCHKGSHHSGHYESFRRNHVYAPYATPDPFSAYAAASRYPSSVPSVTPSPTIEAARNRGLNGSSAPADGQSSTSLSSASLSTGNSRPTSNGVDAAGPATEDALVMSPVQRIDTQLSKQIRTTDPVPGKFRRRKKSNDRWWRISDDKIKEARLSDVLSMQREVYLLFYELERPGDDTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL04</accession>
    <name>A0A1C1CL04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-(3-hydroxy-phenyl)propionate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_04627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL04"/>
    <dbReference type="STRING" id="86049.A0A1C1CL04"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04627"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02784"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="37"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT49141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="557" mass="61912" checksum="7E534F62CAFCBB9D" modified="2016-11-02" version="1">MGISVLSPPNEADLSRPLAVSMETLQESLNVPVVIIVRCLVVERFPERLGAPKAHALSPRSLELLRQFHLDVKKIRQLGTRRRDAFWVNFLTNLSGQQVGVLPYERMDVDVLEDTPEMKMILNIPQPVFEEFVTDVVVKDPGAENLLLTSQDLDGVTTTVEERATGLRFQVRSKYLIACDGARSKVRTSLGIESDGEDSYETMMTIHFNADLRAIVGERVGMLHWIMDPLASGFIIAYELLGNAVLISNFDANLNPVESWNQELCRKVVVSALGIDVPFDILSYRPWLLSRKVARSYRKGNVFLAGDAAHSFPPTGGLGLNSYKIAFVLKGLAGDRLLDTYETERRPVAIVNSMQSVKNGKQIFALLKTLGIGEDVVTARRNLYANIKDPEKMKAIALGIEGQREHFDNLELHIGYVYGSDTIPPHASRYTPKFQVGARLPHAWIRLPCSPLKPVDVSYVEEFSPEDVELRQYSTLDLCDLDKFTLIGELEVAGVKTCVPGKDFDVVGEAGQQWLKGAGLQDGGGLLVRPDQHILMLLDADTKVEEVESCLKQHLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL14</accession>
    <name>A0A1C1CL14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_04849</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL14"/>
    <dbReference type="STRING" id="86049.A0A1C1CL14"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04849"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02775"/>
    <dbReference type="eggNOG" id="ENOG502SEU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="128308at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="335"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT49151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="471" mass="52164" checksum="9F55230229D64BC5" modified="2016-11-02" version="1">MPIKRKAGLAESGIDRNNDNHFVYAPPEDSSEEDTALSEEPASSSPGVSKGRTGRTANSPAKRSATTAAASRSKRQKVTNAPSLERLKAPEADPPDDLFGFPSSSSQKRRHNKVYGKKFVKIDPVEDELDPSDRKDQFSAPETVEMHVKSITKTEFQLVDHVAGPSPMRIRTKTDQKLAGLDSPEPTAKSTKSQFQKFDLPDFPSSNGTETTNSFDVFESPAKESRKRSGSTSSLSSVDELAILAHEHDFKAEQEPDTTGILCPVCEKPVHDSVTLFVPDNLRTLPFQLQQNFCSRHQVADAKEEWEKRGYPKKIYWEELEDFRIREKLPSLKMVISRQAPCFYLAELDAEIKAAKGNRRKIRNYLNEGLINVAKAGYYGPKGARIMTNAVTASLTETLNTALQSDSALKAAGVGAYVSAVLVPELTLRLVMDDMNLKTAKEGRRVLDESTDIGVLLNPDDDQVRLNHEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL80</accession>
    <name>A0A1C1CL80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Golgi mannosyltransferase complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_05135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL80"/>
    <dbReference type="STRING" id="86049.A0A1C1CL80"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05135"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02724"/>
    <dbReference type="eggNOG" id="KOG4748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF5">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="244" mass="28962" checksum="8B1C574E07BB73FC" modified="2016-11-02" version="1">MTDLRDRFWWLDLNTFIMEPSISLQKHIFNSLDKEVYRDINVYNPLNVTHPPETEFLDIVARSPTGDNLTSSIDIIVPQDCDGFNLGSFFVRRSPFTDRLLDLWWDPVLYEQKHMEWEHKEQDALEHLYASQPYIRTHFAFVPQRKINSFPPGACAAQPASDQKADDGEPILDPRFHYNEAERDFMVNMAGCEWGRDCWAEMYMYRELSNKLNRSWREKVKADLIRRWTSFRKTPDKESTTKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLD4</accession>
    <name>A0A1C1CLD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CLCR_04562</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLD4"/>
    <dbReference type="STRING" id="86049.A0A1C1CLD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04562"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02676"/>
    <dbReference type="eggNOG" id="KOG0802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="373"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="236"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="580"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="679"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="787"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="694"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="792"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="865"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="893"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCT49262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="919" mass="100933" checksum="A7EFDA0D012C6BCF" modified="2016-11-02" version="1">MPARMRMRWTAYAGVSTALAAGVVLKALAQRPNFYSAAVYLSQSSANLMILTNLLFVIACSFLLGLQKLLYGNLRRIEIEQLYEKAWFAVTETCLAMTVFRGEIGLTFLAMFFSLLTGKVWGWIGEGRVEVLEQQPPRNPRLFHTRLALSLGLSVAFDLTMLDYVVRQVMRMARPDMMVMFGFEFAVLAVTSISTAMRYAIDLVEIGIVREQKRHRIDEIKRERVQAAVTQFQESLNGQAAGPPSSDAGEATATTAPAPTPTQHTLEQVSQEALNQPVDENEVEVEGWEDKGRYMFYLNLATDFFKLVIYLAFFFILLVFYGLPIHILRDVFLTMRSFLKRISDFMKYRTATRDMNARYPDATAEDIGREDVCIICREEMHPYQPVVAEPGQPQPRPNPVAERMRPKKLPCGHVLHFSCLRSWLERQQICPTCRANVVRTDGAQTANAAGGAGEAGQANGGQHPPGARPGPRVFQFGPLRIGVGAARGNNMFEELQQQLGDAAAPVARGQPQNPGPNAPRQFGVGLRWSRRRPTENLTTQQQLDALETRITQELQDLSHSLREVNVLRLMQAELQRLRNQRAVEGSRQANPATQPPAPAAAPLPPPPPPPPRTVQRTTTLVSDNHTILHAGSERLPPGLTLPEGWTIMPLQPQATHQQYHDGQVRTYPPQPLVPFGGMPMVPPRFQQHPFNVMPQPPQPPPQPPPVQSRPESNTAINGPTGGPAINGAQPEPAGTQSQQLPAPAGGPHVDGVRFTWPQWGTLNHEQLHQQIHQQHHAQGLASLRNQNDQRAADSAGAGDIDATGAAPEPSPAGPTDEERGLLAEPRGRADERRQAEAAEFNSTQASSTPVPALPAWGSAVPRPTNGESSSNDTGAGTSEPQTNRNHDHEAVGTSQAASTSSSQPKNRHPTVEDLVEDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLE6</accession>
    <name>A0A1C1CLE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLE6"/>
    <dbReference type="STRING" id="86049.A0A1C1CLE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05047"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03269"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="42"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="312" mass="35771" checksum="CBCDF2AA258F3AFC" modified="2016-11-02" version="1">MSDSSETVQIFNRVARVESEGESPRIFYVEALARQPKEKKGTILLIHGFPETSYQFRHVMKPFAEAGYHVIAPDKRGHGYSSKPVGDIHQQDPFTKKSLAQDLHTLVRMHIGIRDKIHVVGHDIGAMVAHAYVSQFPEHVETVTWGECPLPGSTAYDKNKHSRLLWHFDFQSHHPDLAVSLVQGKERIYLMHFFDRLAQNVQGAFPPDVVDFYVDRFSMPDALRCAFLTYRAFEKDADHNRKWRQEKGKVKVRNMILIGENSIMGIGEADQMASEFYEDPTMGVVKDSGHYVSEENPQGFVKQILRFIEGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM18</accession>
    <name>A0A1C1CM18_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM18"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07851"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="71" mass="7942" checksum="3312676B93D2E201" modified="2016-11-02" version="1">MISPTNLGYLEVRRIPRAITVYEYNDAPRPTRDPLGVALRESDRPLIDVQRKRSVPQAGEALTAPLPPCET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM64</accession>
    <name>A0A1C1CM64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM64"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07792"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="103" mass="10936" checksum="832A8F6A011FB5D7" modified="2016-11-02" version="1">MLRTGNLEASGALIPGPEDLSIRNAEDQPEKWFGHLVKHCGLLGGDLLTGMEILRATDDVFAVIAAAALPRKRNPRTAMLLGLHPPADVFVEVAREAGGKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM98</accession>
    <name>A0A1C1CM98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homoserine acetyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM98"/>
    <dbReference type="STRING" id="86049.A0A1C1CM98"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07492"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09874"/>
    <dbReference type="eggNOG" id="ENOG502QVPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9972683at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF15">
        <property type="entry name" value="HOMOSERINE ACETYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="58"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="264" mass="29199" checksum="17AADBBD2249AD23" modified="2016-11-02" version="1">MSTDYQIYQLGDFGLQSGKTIPNAFIAYKTFGSPSNPAVLYPSWYSGLISDNEWLIGSDKTLNPDKYFIIITALFGNGQSTSPSNSPDMVPFPDVTFYDNVKAQHRLLTEKLGVKHLRAVLGWSMGAAQTFQWATQYPDFLDIAVPFCGSARTSIHNQVFLEGVKSALLAAKRVSSRGSTFGRVEPDESDAAATKKSRTWTDEERTVGLKAFGRGYAGWGFSQAFYREKLHEKAYGCSPIQLKCMPRDAHDGNQDAPVTSRHVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMC7</accession>
    <name>A0A1C1CMC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11356"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09875"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="69" mass="7408" checksum="18292207BE75AECC" modified="2016-11-02" version="1">MGLPSHQASNAVIYTTYAAFLAFGLVIAWTLRHQTKGEYLATLRTQKGIPLALNFIASGECALRRAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMJ0</accession>
    <name>A0A1C1CMJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07667</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMJ0"/>
    <dbReference type="STRING" id="86049.A0A1C1CMJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07667"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09917"/>
    <dbReference type="eggNOG" id="KOG3328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="81"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="179" mass="19638" checksum="7A37AE6C6C535040" modified="2016-11-02" version="1">MSKKQEPMNPHKAIFKNYGNFLELPLKERVTALERSITDDPNFFGFDTYALKHCSPELLEATPNRTKWSLTIGRELCNKAGNLHGGAAATLLDNLTSTALVTIAKEGFMDEGHVSRTITTSYLRPVPMGAKVIVDCEVHGAGRNTANILGKVYNEEGKLCVTCVHDKAVFSSKGRDAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMQ8</accession>
    <name>A0A1C1CMQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">kap95</name>
        <name evidence="11" type="ORF">CLCR_06580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMQ8"/>
    <dbReference type="STRING" id="86049.A0A1C1CMQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06580"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08737"/>
    <dbReference type="eggNOG" id="KOG1241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042564">
        <property type="term" value="C:NLS-dependent protein nuclear import complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061676">
        <property type="term" value="F:importin-alpha family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051292">
        <property type="term" value="P:nuclear pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046822">
        <property type="term" value="P:regulation of nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060188">
        <property type="term" value="P:regulation of protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1038"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT49815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1059" mass="115967" checksum="53BDB23CBF9664BC" modified="2016-11-02" version="1">MDVRAVLENTFSPDASIRGGAEEQLRQAREGNFSEYLSILSQELANDQASPAVRQAAGLALKNAFTYRDVTRLREVQARWLQGVDPQIKAQVKELAVKTLTSTPQAANSAAQLIATIAAIELPRNEWSDLLPSLVHNVGSGDDKLKQSSLTTIGFICESDDVELRESLVGYSNAILTAVVQGARKEEANQDVRLSALSALSDATEFIRSNFENEGERNYIMQVVCEATQSQDTRVQAAAFGCLNRIMGIYYDKMRFYMEKALFGLTIAGMKNEEEDVAKLAIEFWCTVCEEEISIEDDNQQAQQEGSTELRPYFNFARVAAREVVPVLLQLMTKVSEDDADEEYNVARAAYQCLQLYAQTIGGDVVQTVLSFVEANLRSEDWTHRDAAVSSFGAIMDGPDIKTLDPLVKQALSVLIGMMQDPVVQVQDSAAYALSRICDYCSECIDPSVHLQPLMLALFAGLMGNPKIAASCCLALLNLTERFVGEEGASSNQLTPHFQASVTSLLAVTEKQDANNQLRTAAYEVLSGFVTNSAHDSLQIVAELSNVIIQRLESTIPMQKQIVSIDDKITLEELQVSLSSVLLAIVQRLEQNIGPQADRIMQINLELLNVTGNTSVPEVIFQIVSGLANALSADFLKYMDSFAPYLYNALGNQEAPEMCSLAIGLVSDIVRALEDKARPYCDTFMNYLLNDLRSDKLSNALKPPILETFGDIATSIGVHFETYVTVVAGVLQQANNVSVANDVSFDMLDYIVSLRSGIADAWSGLILAFKGTDKVNILQSYVQPIFEFLQTVSQDMNHNEGLLRACMGIIADLSEAFPGGSLADYYRQDWVLKLIKETRTSRDFTPRTINAARWAREQVKRQTQHQAPAPAPAQHLQPTPVRALITICEGNGHFPSEADTLIGIPEDDEDPGRSQNGENGHVDTLYPLESHLHGIGDIHAPRLDTDRAVNLPPHPLIGSPSSSQWLDLNAPNVSPATGAIVQSPTVPPLDLQSRLQQQQQYLGFGSPDNVSIRDFATSGGPVQPAANRNVSYSSTILSYDGDVDSPDADTSSALPPDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-03-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMT4</accession>
    <name>A0A1C1CMT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07740"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08746"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="139" mass="16188" checksum="D20C43991983B381" modified="2016-11-02" version="1">MQAIVQGEIYALVHELLALRRRDPDPDLHDLLFRDITDELDAIIVVDDVERSLLQDVESEKRLIARIKVLERQRHIRTLREAKEKVELAMEQYVAAVEAQAWEQKAQASGLEVQTRVDEANEALKKRTSEFEELKKMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNN6</accession>
    <name>A0A1C1CNN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate binding family 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNN6"/>
    <dbReference type="STRING" id="86049.A0A1C1CNN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07115"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09005"/>
    <dbReference type="eggNOG" id="ENOG502R3TN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5290283at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09220">
        <property type="entry name" value="GH64-GluB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.50">
        <property type="entry name" value="Beta-1,3-glucanase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032477">
        <property type="entry name" value="Glyco_hydro_64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037398">
        <property type="entry name" value="Glyco_hydro_64_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042517">
        <property type="entry name" value="Glyco_hydro_64_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165:SF1">
        <property type="entry name" value="GLUCANASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16483">
        <property type="entry name" value="Glyco_hydro_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52006">
        <property type="entry name" value="GH64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH64" evidence="2">
        <location>
            <begin position="65"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="477" mass="49719" checksum="EC543E2674D3A207" modified="2016-11-02" version="1">MRRFKKVLQRVRSKGSPPPPPPPPAAQAAISEQRDPPPSQTPAPGPAPGPAAAAATATAATAAPTSQATGSMLNIALQNQTTSQTVYAYVTGRALDRGNAWFLLSADGHTPYYPSSPSSVGSPMAQNCAIPLGRPGNTVTVTIPHIAGGRIWFSIDAPLTFLLNPGPALVEPSVTNASDPNIHTNWGFAEFTFNADQLYANISYVDFVGPPIALTLTSATLPPQHVAGMPSDGLDQVCAGLRAQHARDNQGWDQLIVTTAAQGAGQQQQRNLRALSPNQAMVTNPALFATYYDDYVARAWRKFAAQPMSVDTQAAFGTVSAQVDHGSGTLNFRVADGAATGNAGGSATTPLSFTKPSTRDIFSCSTGPFATGSNPAVNAIIPRLAAAFNRSTLLETDVFPAPQALYYKDATTNHYSRIVHAVNLDGKGYAFPYDDVQPSGGADQSGEVHAGDPILFTVTVGGGNAAGAAGTLPRREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNX1</accession>
    <name>A0A1C1CNX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06988"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05782"/>
    <dbReference type="OrthoDB" id="4155902at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="479" mass="52429" checksum="6B71B1A0A7F0A07B" modified="2016-11-02" version="1">MSPIKGRPVLSATASITSRTSSLPATPLDEIPETLWPRVLRTATTPEASTPELSIDEITSTRLSLDDQAILTTLPKNGDRKEGQTRRAMSRSTFGSMWGENNSRFKKMTQKLKNIPSGLFTRKDRRSREALTPTTTRTISSPEPSLPQLELTTELYIPATRTSSTSGNSGHSKPVTLMDYECKPKESESESRREEMAKPLPPHFLRAPTYNSRASASAGNLAQVAEDRLLHGPRSLRATSRQAIGRATSVGSVEEMRTHAFGNRRNKRPSLSGLSFHHSSAPSISRTSYSTCRPATHAGSVSSVSATLVPQKPLLFMDGPKAGSESLWRIPDPQNHPSASSTARPVSNGVAAGNNQDGAPAPNTNCTPVADLGVGFGDLPDYTKVPICVPRRVEPPRRSRRAAEEDLAEENQGLARHSETNISTPTFSDRSFGSSLQAQWSIRSHLERQALEWEQEKEHEVRESRAMALYATLFRGGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP71</accession>
    <name>A0A1C1CP71_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP71"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07773"/>
    <dbReference type="OrthoDB" id="3453214at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="96" mass="11200" checksum="2DE52049F46E4CE0" modified="2016-11-02" version="1">MTHQCRSKQDMALLWIRDQPLAWFRDAPIDMRDIDLIRAERVAWLDYSKRSYLRKVYHMKAGDAFEAVRACLRDNTPVPSSTELLPVTLTTTPAYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP97</accession>
    <name>A0A1C1CP97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fabG</name>
        <name evidence="4" type="ORF">CLCR_07340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP97"/>
    <dbReference type="STRING" id="86049.A0A1C1CP97"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07340"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05699"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF127">
        <property type="entry name" value="3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="335" mass="36161" checksum="13C02B8EB7DA4A63" modified="2016-11-02" version="1">MSAIEIELAEADVGKHLNFPAPPRLISSLCSSWCIGAVTAAVQLGICLAEIYSCTQAGTFRHYVRRQRDQRPTGPNHGGIRRVEFPEEFSERAGTDCGRIGAGCARDLYKNGCHLALTYSKNKANVDSLISELQSSSSQSDLKISSHQVDMASTEDMERLYKEIESQHGHGPDILIANAGYGKRVPQIVDITYDEFDYTILINLRAPFILAKLAVPHMAQQKWGRIIMMSSIAGYGGGINGCHYAASKAGLTGMMRNLANKLAKDGITVNDVAPAMIGETGMIPDAKFLEGTPGDVRNIPVGRLGTPQECANVVTMICRTGYLTGQSILLTGGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP99</accession>
    <name>A0A1C1CP99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP99"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07615"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05672"/>
    <dbReference type="eggNOG" id="ENOG502SPFI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3928002at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049:SF2">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650946" evidence="1">
        <location>
            <begin position="17"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="207" mass="23402" checksum="EC965FAD543B1B6B" modified="2016-11-02" version="1">MVLSLITLAATVPLLATSTIQLQEQSQTKQEEAELKLKTEKCHLDGRATKRMTAKRQEQFRPMRVVLQDGYLLLEPRAASRKHPFTGYLLPFPEKSYDGLVSTIDADNMLNWIFINKDSYRLQYGVRAEAQAQWTGPMKLVGDQNEWRVAFDGWEGFVAVQEGEDCWALYFDKDDNGLADKVKGQAVVEIELIRSVLDGNSKGTDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPH9</accession>
    <name>A0A1C1CPH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_07186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPH9"/>
    <dbReference type="STRING" id="86049.A0A1C1CPH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07186"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05594"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="71"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="185"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="417" mass="46144" checksum="845BB0597CC0DDAA" modified="2016-11-02" version="1">MSAPEHDEATQLQGLIQQLSDAAKACDYSPGAKGYVARTNVAGIAKDIVRLMMAPSDMSMHHSVNMLEIVSIRTLMGLGVFEKIPVDGSISLAELSKATGVQDSLLERQLRILVGTKFIDQTPSYEYVHTKFSRAYIQVPGPGNFFQFMNDECLSTLVHLHSYVKDRAREDHKPVREPDDPLHNPYTRRHGMDGHPVWEIMAQFPDRLRAFQLGFMSQEDSVPIIGFYDFSALFNPDTDGDRPTVVDVGGGQGQSILQILKSFPSLQADRMVLQDLPEPIAQSKEPKLLPEGVKAMVHDFWTPQPVQGAKAYFLRRIIHDYSDENCVKILSHLRAAMAPDSKVLIADMVMPKRVSEADLPAAAMDNCVMVMGGKERTADGMKKILDEAGLKMLKIWQSREGGATGNIVEAVLPSPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPV3</accession>
    <name>A0A1C1CPV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPV3"/>
    <dbReference type="STRING" id="86049.A0A1C1CPV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07632"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05484"/>
    <dbReference type="eggNOG" id="KOG2972">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2017544at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="2">
        <location>
            <begin position="40"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="196" mass="21285" checksum="5B83BE0B3551E664" modified="2016-11-02" version="1">MNSRLAHAIAVAKKGQLSKTSIEHAIAKGQGKSPTGQALENVTIEAMLPHGVAAMIECQTDNKARTLTDIRYIITKAGGTATPTAFMFEKKGRVCFEEQEKISVEDALEEAIEAGALDISSEDNRLVVETEPADVMAVAQKLQKKLALQVEKAEVVYVPNEDSVVTLSEEEEDEVQSILKSLEEDPSVQNLYINAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQN7</accession>
    <name>A0A1C1CQN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinamide N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07144"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05212"/>
    <dbReference type="OrthoDB" id="2106152at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF104">
        <property type="entry name" value="N-METHYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="44875" checksum="3BB2DFC859998D21" modified="2016-11-02" version="1">MGASPNLAQSTKGRSPRNRGLQGARMNGGDLSHARDQVVSPAARQQGSSRMFASRITTPPSAIPRVEDTFASTPSCRSTDDVQNSHGTPGSHVIYHSRRFGDLQLRIPRHPDAEEGRKLFAHHLWNAGVICADALEEASQDDETRPFHASNSNPGLGHPASAWDKRYWDVRARTVLEVGAGTALPSIVAALSGAASTTITDHPASPALTTNAIQQNVKINVLERDRRRRGTDDHTSSSSSSSSSSLLPSPDVTISGYTWGTPTFYSPSSYGKRSPRQPRAFDRMIVADCLWMPSQHVNLVKTIVRYLDESRPGSCALVVAGFHTGREIVGHFFEVATGQSAPPSSLEDGNGFEETKSGATKDPDLEEVRCPLRLAEIFEIDVNGLRRPWEPVRLGEAQDAAKRWCVVAVLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQU5</accession>
    <name>A0A1C1CQU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQU5"/>
    <dbReference type="STRING" id="86049.A0A1C1CQU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09194"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09503"/>
    <dbReference type="eggNOG" id="ENOG502S3ZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="174" mass="19009" checksum="EBF532CF8A4CB852" modified="2016-11-02" version="1">MSAATRNTAVKVCTERAMEAAAKRFFSLPYFAVTGASQDKSKFGYRLLAWYHQHTLPVTPINPTRPSISLPSKTYDTVPSVSALPHPDQTALSFVTPPAITRRTLREAKAAGVKAVWFQPGSFEDEDWKYAKENFESAIGGFEDGTVGGEGWCVLVDGENALRGAGKKIVKQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQV4</accession>
    <name>A0A1C1CQV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1479-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_08521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQV4"/>
    <dbReference type="STRING" id="86049.A0A1C1CQV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08521"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09513"/>
    <dbReference type="eggNOG" id="ENOG502QW87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="438" mass="49065" checksum="C9E3AEA855F2BE75" modified="2016-11-02" version="1">MPGRLLSWPDWPEFTAAKAEHGDDLVGYKRTIAEKYGKDNIIKSWLKVCQELESVTDRIAEQGTSAIPEVTFEEVFDLTPEKKQALKDVGCFVVRGVFNQEQADEWFKDLKEYVAANRASIGGWPAETPFILNLYYSPTQMAARSHPNQLKLSRELNSWWHDKSGSSYSPEPLSYADGVRIRPPGVAFRGLGPHVDAGSLCRWADPTYQSVYATVFSGNPESLDNYDLSARQHANQAMFPGSAHSRVFRAFQGWTALTSAGLGEGSLMLYPNVKWTIAYLLLRPFFRAPEAEADVMDASKWTFDVEDPWFPGTFRDDSQLLSPTSHPHLRLQECMVGIPSMNPGDTVWWHADISQMCHAVEVEHNGDHEASVAYIAATPRTEENKSYIKRQLEDFLNGRPPEDFRTGPAENTFKLHTGEAGILGGEAGRRAMGFDLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRS0</accession>
    <name>A0A1C1CRS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular GDSL-like lipase/acylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRS0"/>
    <dbReference type="STRING" id="86049.A0A1C1CRS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08285"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06888"/>
    <dbReference type="eggNOG" id="ENOG502QVFK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10071171at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01830">
        <property type="entry name" value="XynE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053140">
        <property type="entry name" value="GDSL_Rv0518-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784:SF3">
        <property type="entry name" value="GDSL FAMILY LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650996" evidence="1">
        <location>
            <begin position="25"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="233"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="453" mass="48879" checksum="D19FAFBF51E7B729" modified="2016-11-02" version="1">MGVQGFSVSTLLLLFTYLTAISNALPRPQARQALVTTPSIPDGHWIDTWAAMPQLTEYTNLPPPPYNTTTTQFYNSTIRQTLHMSTGAEQIRIRISNAFGLTDLPITAMTVALPFNGSSGVSAIQPSTLQTVTFSGGNPGITIPNGALAVSDPLNFPVQPLSTITVTLYLATGQNGTAITSHPGSRATSWFTMGNQVGATNLTGPLLNSTAHWYFLSAVEAWSPPDYRTWAIIGDSITDGRGSDTDQNNRWPDLVYARMAASNSSTLTSISFINQAAGGNRILHDGLGPSVLSRLERDVLSHPAIRWVMIFEGVNDIGTADPTPSNQTILYDALISAYIQIARRVHAMGIPLFGATITPFSAPDYNTTVQSYSDPLREQTRQKVNDFIRHSGTFDAVLDFDAVLRNQSFPSQLADALQGGDYLHPNGAGYARVAETFDLGLFERFEGGVGGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRS2</accession>
    <name>A0A1C1CRS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08532"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06901"/>
    <dbReference type="eggNOG" id="ENOG502T55R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4160560at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="473" mass="51110" checksum="D235716C21F05E60" modified="2016-11-02" version="1">MPEPVVIATSIFSGFNSFVKAISLAAHYKEVPNEVRQLHTNIERAESAINIARRLLRSKAHYLDPRLIQETEESIEKSNSALLLVRDSIEACRKDLEIRQTVTPKNRVAWLLWKNQEFLSQLQTLGNCLGALDRDIGRLEMAHPPIVFVNGNLGPPAYADNDRKPGKGTTFRVEADDEEEKKPPFPRSPTKRIRSHSRSNNGSQVNLNLDKRIGTRRGGLRNRSPQFTDGDEGYESDELPLRPRSRDDQTTPDATEDLALFANATIGVGLDDGSGLGLGLSISQGQLSVRQMDFLQQAGPAMAAAATSRSRPGNSELPEPSELHVEAEQQPKPDPGAIQTPTSIPVPTPTPTPNLYGLSSKNPWRRLAVQQSTSTLNSSVGTFHRVVPPNAVDPDPDAASVISTTTTAVEDVDESDITRNLLGLSVTAPAVPSGGGSGPGPGSGSGSGSSVVGLLSPELEPKKVKWRRKSVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRW0</accession>
    <name>A0A1C1CRW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nip1</name>
        <name evidence="4" type="synonym">NIP1</name>
        <name evidence="7" type="ORF">CLCR_08004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRW0"/>
    <dbReference type="STRING" id="86049.A0A1C1CRW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08004"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06854"/>
    <dbReference type="eggNOG" id="KOG1076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000300">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="607"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="819"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="843"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="843"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="856"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="869" mass="98438" checksum="BA65922B607767B6" modified="2016-11-02" version="1">MSSRFFHGGDSDSESSSSEEEELYSEKEEESEEESEEEDEDEDESSEESSEDEGRGLGASRFLKPSGPGGDDSDESEDEDRERVVKSAKDKRFAELEGTIKAIENAQKIGDWAVIAAEFDKMNRQVVKVTQQGATPKLYIKMIADLEDLITETNDKQKAAGAKKMNPIAAKGFNAMKQKIKKNNKDYVTEIDKYRENKDDFMESDEEEPLEVERQTRKNRAQRIDAIEAAIDEEGFATVGKGGKALVYTPESILKHLRSIIESRGRKNTDRSEQIRIMERLLDVANTPYQRIRVLLTLISTRFDVTTTSVQAYMSQDSWRSAQREFSTLLQTLEDEPRYVVTEGAEEWEDDDKQPNPTADEVFKVPGSIVSLVERLDDELTRSLQQTDPHTAEYIDRLSDEQLLYTDIVRTMIYIETINKRVEKLEGKQDNVNRTVIRRLEHIYFKPTQVVKILEEKTWAALPSSLNSDLTPRGQFVEVASLVKTLCNHLFEQSEGIIRARAMLCEIYFLALQDDYYRARDLALMSHLTENISSFDVSTQILFNRTLVQIGLCAFRAGLCYEAQGVLQEICGSGRQKELLAQGVIMQRYSQVTPEQERLERQRQLPFHMHINLELLECVYLTCSMLLEIPLLAQTGSSPDVRKRVISKTFRRMLEYTERQVFQGPPENTRDHVMQAAKALAQGDWKKCQELISKIGIWDLLGADNKEKVKKMLAEQIQEEGLRTYLFTYAPYYDTLSITSLSGMFELDSKKISAVISKMISHEELAAALDQVNDAVVFRKGVELSRLQSQVITLSERAMGILESNEKVLETRTAGMVGGYTRPEQQRGRGGRAGGRTGLQNLARQGQQGQRRPGGQQFGGGALGGAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRY5</accession>
    <name>A0A1C1CRY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptide hydrolase</fullName>
            <ecNumber evidence="11">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LAP1</name>
        <name evidence="13" type="ORF">CLCR_08658</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="11"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRY5"/>
    <dbReference type="STRING" id="86049.A0A1C1CRY5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08658"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06830"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008448729" description="Peptide hydrolase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="12">
        <location>
            <begin position="173"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT51248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="389" mass="43231" checksum="F04FCA9051F3755F" modified="2016-11-02" version="1">MRSLCFLATSLATAACARSLHNPVQQAIRADEQVPFGQDSCLIELSPGETRWVSEDDKWELMRNGIKFMDITENGHTYPYVVSDLASSTVTYPKKPQHNQTVRSLAKTLDKDNMRKHLETFTSFHTRYFRSQTGIDAALWLHDQIKDVMEASGAFNHSASLSLFPHSWGQSSIIARFPGKTNHTVVIGAHLDSINMFLPFLRAPGADDDGSGTVTILEALTALVQSPKIVNGSAENTVEFHWYSAEEGGLLGSQAIFKSYHEEGRDVKAMIQQDMTGYVEQTIAHGKPESVGVITDFVDPALTKFVESIITTYCDIPYTLTKCGYACSDHASASKYGYPSAFVIESDFEYSDKKIHTSDDTIKYLSFDHMLQHAKMTLGFAYEAAMAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS42</accession>
    <name>A0A1C1CS42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS42"/>
    <dbReference type="STRING" id="86049.A0A1C1CS42"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08607"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06758"/>
    <dbReference type="eggNOG" id="ENOG502S1RX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025040">
        <property type="entry name" value="DUF3984"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13136">
        <property type="entry name" value="DUF3984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="437" mass="47596" checksum="934A995BF5142A4B" modified="2016-11-02" version="1">MSVPSPTTLSRSSSFAPGSHRRSHPNLQHLSLAPLTPKYPIDPADYSAYFDPSTSELHTSASISHVASLPSPGGILSRSGNGSAANSRVQSRANSRTRLNNNKKKNNNNKSFVTIQAPPLPLPLTEGTGGNLTAAATATAAPYGALTSEGLGHKSISVEEKEKEKRLSSLSLHQTQSASTYTGHHPLHKSDSSWLIQTGLTLTEGSRESKGQSWISKRDSSTSLATPLEERPSMAMTGMRSGRNTPGNLSRRGSFQEKRRSRRSLAMTPVPSTTPMLEMDAPPDWADEQSRAEIAAQYHEDFGDEFSDDDDDDDPYGVLDFEGQFDSEDEDELRRSITGYRLGAWMDGLVDVFLRLEDDFPGSQLEATKAVREKGEGKDQNDGLAASASSRPPKDADLQAGHSVRFDDSVEPPPERPKTVWDDVAWFGRMVARTVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS73</accession>
    <name>A0A1C1CS73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS73"/>
    <dbReference type="STRING" id="86049.A0A1C1CS73"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08465"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06736"/>
    <dbReference type="eggNOG" id="ENOG502SH7B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1937642at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="492" mass="53064" checksum="9F2F69CC6CC91004" modified="2016-11-02" version="1">MPRRGHTTSPSQAEQTYLAFSLRWGALTALVLSILLFKSPLSAMPPVLFDIVRRSFDPGEPSREFWAQWKNPGDVFSVLLILGGDVVARALAQLAGSRLTPVAFSFGKFGWVAFAVAAVVSAVGENKLMPLPDCACKVINGESGYVRENTSWIIGRIVRDFDHWKDAAVTSKVKELVEKKFEFDKDKALQETGSSASVEKSTQAGLCVSVYEAEPAGRGYPGYDALYWIGFLTTFVQLGIAAIPAGIFGDWGIFLITIAGISLSVVTGALPQWAKEKWACRSKSKKNVILTRGNGSQHAVVILGNGNGLDLEDLAAGQTNVDVSASWFTRVTLIALALLWILLLITAAGIQQNTWFLLAIGGVGILQNIFVAGWRRDPKAFGVPLKFVKVIGENKVMEALYKVEEEYDHVGASLIDTFFPGKLRSSEKTRWEDYARIAKQKDDAAKAAAQAGKQQNGGTQSTAANKAQGAGAATQTQPATNNAQTTFSGTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS96</accession>
    <name>A0A1C1CS96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08984"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06711"/>
    <dbReference type="OrthoDB" id="10319107at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="270" mass="30664" checksum="20151BCE62F22A87" modified="2016-11-02" version="1">MPRVRAYLRSTHYPPEDFNLEAETEAFQATVTVMAATMPKLVETLDNLQGELTKEVCNSFKSSEPHVFFKNKYHTFLEDMMLDIFHDKPPQLSAFNLFLWTLQYEAKQTAGLLSGRDDHGPLPPSWRSWVVVMLSNTLVFQHHKLTTEKENVKQWTLDIFTSVNDARIANEVPGTLLHQTWKNVYDRVQDFNRILTFMSIGHSNLMAEIDRQEGGEVGKSGPRKPIHAVLGQEITKADPKIMIPDLAIPEDLGAPPVDTENEESGLRGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSW9</accession>
    <name>A0A1C1CSW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7908 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSW9"/>
    <dbReference type="STRING" id="86049.A0A1C1CSW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07892"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06505"/>
    <dbReference type="OrthoDB" id="4154893at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057230">
        <property type="entry name" value="DUF7908"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25485">
        <property type="entry name" value="DUF7908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7908" evidence="2">
        <location>
            <begin position="220"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1499" mass="157891" checksum="C3EA335C15442D3E" modified="2016-11-02" version="1">MRSGGVVYVSFGTSACVGTPVSLVATVEGCPVSSSSTAFSTTTAAQSPIAEPSTTATATLPTSRTTTAHATSSLSTLDVTTAQTTTSTLTTTTTSTVPDTTTSSECSMEIITTTLKKRDVLEVRTITVPAADCSIPSSTTSEHESTLTTTAADREGVPSTTEPTTSTTLDSTSSVDTTPATSADDASPTSTTSMTTATMTVTTVGSSSTTSSADTSSPTFGQPFSIQLNSAGANKHKRDISVVGYVNGTLTRVTSTADAVSFVLTSDGVLMIFGTGLVVGFSGNPGTSPLMIYPSVSALPTTIIWSFTGGALVMPGAGFCVGANNVMSVSVGSSTDSGCAPVTPVPNTDPDSYNTEVASSITPSPQTTTSTTLGSTSSTLDASTTASSSLLTTTTSTTLGLSSTTASSSLTTTTAIPSFTSLTTTVFVSITSTTSLDSTTSGGAATTSTTTVTKTEETSGPNCSILPLEDQTAPDGTQYTQFFYSCHAAIPATLGSSYSIATSGDEDYSSDPTAFLSQCVANAERLGAGVWTYYQSSLDFKWHCGFWNGLTADDGLFVDDSTVFTMNAMKVVGDDDSPSITTTSSSSTTLASTTTTIGVMTTVPASAPICTPDSSYFDHVHCPDVYIYDSVQECQCFNRVQGGQNMCAYTFYYDRPCMWDSECAGYGEWSYCLTASFTGTGPQGYCSDNDSSRTCLTGGYQANTTTPSAIFSTPTVTSSTMTATSSSALATETCAGLCSTKTVSSGSHVWSQVEAGCVEYNFNWVWAVATPFPAGVSDCDAIQYCADYVVQQGMTAFRTFWVPAENQWHCDAGLENDETGDYEYSPPQANFYMYNLLTASTPSTTAATTTTSSVTSTTSPANCVQTSASVGDILMTTNGNSWVNFFSSGCGLSLDWQSLNFNNLYVYLRTEYTYEEALLECASIADTDGSPVFEFETDTRNNNRWVCWTLNDITNDPAQFQPYGGIADAYGWYLPSRMVSATPTTTTTPPTPTPTCANGAIVTDTNGDAWETLCGQGSSYGWTFFSSYSDVATLSDCITKCNEDASCNAVSIEYRDAPNNNLCGFIYTSIDFQPYDFEADTAIKVSGTNARPPINVPNSSSSTTSSSTSRTTTASATSTTTPPPACTASAIGHVTALYDTTQTFRNFYTGCGESMEGGTTGGLANFPNQFATMWRASANWEDYTFDQAVSRCVQFAVDNGATAVEFYVDVNQNWLCVGVNDVTVDDSSFYADSNVVNVWGFVWENSCQNAPLNDITAADGTIFAEFYTGCSTSFQGNTPGGLVNLNRVVSVNWQAPDYSGYTFDAAVQKCADTTISQGGNLFEFYIGTDDWWYCIAVNELPATTASFYPDAAIGKVWGFAITESPDVCEPSQLAGSVQLANGTTYEEFYDACHVSLQGDTAGGVGWMTTVFGFNNLPGDDGNYGGWTLQTALELCIRDAAAAGATVIEYYENTDEVPTRYCFGVNNVPAQEDSFHGDGTVGRLWAFKLDESTLPILLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT10</accession>
    <name>A0A1C1CT10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT10"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09111"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06472"/>
    <dbReference type="eggNOG" id="ENOG502R8C9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23353" checksum="E9FB597656F9AE7C" modified="2016-11-02" version="1">MSRKVHLVRHAEGLHNLRDDPTIPDAPLSERGLDLAEELGRLFIHDHSDSVGAVLASPLRRAIQTSLAALARVLGAAHYPANSGRGARTGGVTLVLDPDLQEISTAACNVGSPPHELLVEFPELAGQIGRLPSRWFEKTGLWSPARAAVAQRKIRILQRLWDVSEQLQGNPGGREDIVVVTHEGVMLELVPGTHVPMGTYRTFTLVNTGTEIVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTC5</accession>
    <name>A0A1C1CTC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Ptp2</name>
        <name evidence="7" type="ORF">CLCR_08013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTC5"/>
    <dbReference type="STRING" id="86049.A0A1C1CTC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08013"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06349"/>
    <dbReference type="eggNOG" id="KOG0789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="266"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="521"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="711"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="624"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="856" mass="94491" checksum="B8188CA9986623FD" modified="2016-11-02" version="1">MSATTTASLKSSSHPHSHAHSHSKSHSHSHSHSHSRSSRPSTTPRVQPAVASVGQPVPPLLSPTSVRSPSNAKDVKSPSPSYFGFVVGDDSIPADSNPGKHVRQNWNFTGSNAQKDVATPRHVPVESNPDFEAFRRQSEHNHRFALNTAFRPSQSRTNSDLSSTASPLAKRPAIERSAQSTANGNTRMEDVSFFDIPRQQSPDSINRNSVADHQHARLSLPNHEFRGPPSGISKISSRSETLPSSAEKDVPPIVSPTQIAEILRSQPSNVLVLDLRVYQQYASARIRGALNLCIPTTLLKRPAYNVQRLAETFSSARDQESFARWQTCSYIVVYDANSSLAKEAVTPLNVLKKFTSEGWKGTGLVVKGGFLKFQKLVPELVDDGPVQQGNGATSQPLSISAPGKDTLAVAGGCAMPTTKSAANPFFGNIRQNMDLIGGVGQMPIKKPHELTAETEKHMPSWLKRAASKSNEGKLVSDKFLNIEKSEQKRMQDALSAKVSYGTPRAERPERIQVAGIEKGSKNRYNNIFPYDHTRVRLQNVPNGSCDYINASHVKAEFSNRRYIATQAPIPATFNDFWRVVWEQDVRVIVMLTAEAEGGQVKSHVYWKPGEYGQLKLKQLSERQVSLEPKKPANKPAPTTRPSMAPRRSTTANIPGERSREEVKSPSTKAAPTAVVRHFSLSHAAYPFEPMREITQVHYADWPDFGAPASPTELLGLVEQVNKYVRGSASPSSIVGPDEAAPKGQRPILVHCSAGCGRTGTFCTIDSVIDMLKRQKLSHDGDKDRMDVDADEWVTRDDVDLVAKTVDEFRHQRLSMVQNLRQFVLCYESILQWIVALESEQRQKRPGLPDPRRSYHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTK1</accession>
    <name>A0A1C1CTK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08580"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06298"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="451" mass="53218" checksum="CB87A017A6183EF2" modified="2016-11-02" version="1">MPLEAAMDAVTHHQDPETAAYDYELSMRMTEQMNMHGTQGMNMHEIQGMNMHETQGMYGEPLQQSAAACGVPTHQHQVDHADPAQGHQTWDCDAPPEHEREADPNYEHNQGYHDKYDPVHDHVHGQDYNHPYTHEHENEHDRGLANDDDYGYKYEESYDEKYNVNHDPEDGQCGEHNQNREHHDYPDHQHDHSHGYDHDHGHEPQHEHGSDHGHEHYQDHESNHDHEHNHHFSHHAHGHEHEHEHRHEHDPEHGDDNHGKHEHDDPNHKHEHEHEYHNDDDHHSDHKHKDKHHDDDHDDPDHKHEHEHEYHNDDHDRPEHEHKNKQHENDDDHPEHGHEHEHKNKHHDDDPDHPDHEHKNKHHDDDHDHPDHEHKNKHHNDDHDHPEHEHKHKHHDDDDDSSDSKPQGCDGKCCGGKCDGSCCGGHCVGNCKSDNPDVVRTTEISLDVSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTP4</accession>
    <name>A0A1C1CTP4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Only prolin and serin are matching in the corresponding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTP4"/>
    <dbReference type="STRING" id="86049.A0A1C1CTP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08448"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06243"/>
    <dbReference type="eggNOG" id="ENOG502SJFJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3882058at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="515" mass="56278" checksum="D3D1193488C84DA2" modified="2016-11-02" version="1">MEHTAVYPSDAPARSTHSAASSVSQSSPTQSLFSKGHSSRGSGSSIASSPVPRDSLDMFGAAKRLEDVTEEPHEKDEFDGYTLVNDGICDWSDYDKALSHDYGHPSPTTTPVDLVWSLGETDNWLLSPGRRQPKRRRSMEQPLTSHGNRLGGRFSSLSRRWKNRSAAGPQLSIVTHHSSPASRSGSLASSQVRSPALSAISKHEGGLPSSPTLPYVHDGPFSAEAAPIDIVRRPNEDDEAEPGQATTPLLPPLLSELGKKDEPIHSPLQSPAIAPTTALVNSRASLDTPLSCLPSPPLSTKPSMVSMHSRSRTNTLTNSPFGDIPSMQLLEDPSDPWDARLGHANFTIHPEPYVPDVFDLDSYTEYRKNWDQARTSYAKHIARTVEHYGSTSKVYKLTEEKWASIDNVWQRQHDLMRTAMAPVLARLSDGDSEMQDSTASSAVLEKPLSKLVVPLIDDKSGKFPELGDGEIVGPMSVARPRILTADHDKNLGAKSPPLSPHKRNLIRFLSDIFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTR5</accession>
    <name>A0A1C1CTR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09102"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06221"/>
    <dbReference type="eggNOG" id="ENOG502S2V4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17821" checksum="BF81DA584F9EAF2C" modified="2016-11-02" version="1">MPENYINPARPKIRFSLIECIAIGIGAGAVGVAAMTLGEKTEQALTHRPNSYVPGKTLARLFNLDFHAQPERINHAMHWGQGMLAAGVRGAMSYYGIVGPFGSYIFMGVRLLVDQTLENWTGVGALPWTWPVSEQIIDLLHKAVFAAVTGYVADRIILGEALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTW1</accession>
    <name>A0A1C1CTW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">37S ribosomal protein Rsm22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_07967</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTW1"/>
    <dbReference type="STRING" id="86049.A0A1C1CTW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07967"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06207"/>
    <dbReference type="eggNOG" id="KOG2539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="873"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="834"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="873"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="922"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="954"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="999"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT51922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1010" mass="113515" checksum="E0ABC96774EC4892" modified="2016-11-02" version="1">MLSRARSSRLCHGCRQDLQAFFDKGFCGPPVALKNGTARLPLQWRRSVGPQHRQLRHLGGNAASFQQHTSSSHRSGQPQPDDEQIGANLDAEQLQVLQELETALGRPVEEAIEADRAASTSIQDLFPDSQLYQDEEVDDVLRGTNDPLATLRASGASHEDLVREARQVYGDGLPQNALDEEELKIYKRLYGEPRSLSFEEFLDEEEASAVEEAAPHQLMDQDGELVEYDASPAAIRENEAVEEEDISQKGTPRAAVGGVGLEPGVDENFSPFAPPDVRTQEIARMLNGQVIEEGDREEEDEADEEYDEEVDPSMREHPFTRLGKFATTPRSIFLSQDNFVEPVQRIMSNFSNKHLKEMCEKTFGGPGFPDSPLTPRSGRSRRQVPIPLGASQHLMGEMEANAYITTIMPPTYAAIMSVLVETRKRLGTTWLNKLLAKEGGPRILDAGAGGAGILAWREIVQAHWDSLHSSDKDPVPPPPPTKSVVLTGSDTLRHRAAKLLENTTFIPRLPDYVHTRDAPTLEDDRPAQQRKQFDVIIAPHTLFPLHEEYMRKNHVQNLWSMLSSEGGVLILIEKGIPRGFEAIGAARELLLERHIAIPEGATTEYSSLHNDPEDVHSRSTGMIVAPCTNHERCPMYKTPGLSKGRKDFCSFQQRYIRPSYLQRALGAKDRNHDDVDFSYISVMKGEDLRQRQVQSWSSLEDSLSAPVHPSPQVATEEYESWTELSAKGFEEVHPESNLTNIHALFADGDKPPSTLPSAHTLPRLVYAPMKRRGHVILDVCTPHGTIERWTVPRSFGRQAYRDARKSRWGDLWALGAKTRIPRNLRLGGLNTKEANKARGRNERLKQQAQDLLERMQEEKLDEMDEMQEMEREFREGRFLDEGERAKKSRPSKIKREQSNEGVEAFTMDDFDMNELNPPLISTKKQPQNQNQVPSHLGRQATRRTEPSMPSAEPAGKDDLTPEEMQTLREWDDILAGGSGLPVKGARSMRQYSKFAPKGRKSETRKSGKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUD2</accession>
    <name>A0A1C1CUD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_08019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUD2"/>
    <dbReference type="STRING" id="86049.A0A1C1CUD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08019"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06054"/>
    <dbReference type="eggNOG" id="ENOG502S5RK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="750" mass="83309" checksum="9F264C6D249BF107" modified="2016-11-02" version="1">MVSSVPGTGTGSDASPPQTNGHGEKRKAEAESSLDKLPHTRSKRNRYISIACNECKRRKIKCNGNTPCQRCGNLNLECVYAPNCCTNSLKDSAEFNQMREHISALQEQVNDLYASLNELRSRSEIAYTASIDPQFSHDGSNRSMSISRTLPPLISPKRAPPKALPQFHGPTSTVYGLDVAKSSLQTMGITHNVADDGLMSRERSRAASPVMMLPAHPSKDPLWLIDHSEVVRLCRVYEEEIGIMYPVIDIDKVLKQANSLYKFIGASLRTGLGQPSLPGADTFDDEETTVLKMVMAITLTVEGHGRSELGQRFFDASKPATDLKLVTAIDIKSVVLTVLTATFYFQKDEEAQAWRFIGIAARMCIEMGLHRKDSLLKSFTNEAEYQQAIRIFWTVYALDRRWSFGTGMPFALQDADLDPALPEPDEGHPYLKHITKYNQIATKVWYHNLAYEAGQNTKKDEIGFLDYQILQWYSQLPESLQFNNRDLARENEIPGRGVRRLRLLMYLRKNQARISIYRPILHSATSIMDNRHYAQNVIDVAKDTINTLTAVNQMSDIYKTQQVLYNYFLVQALAVLFLSVAHAPAVFCGQTRQEFYAAIEIVKGFSTKSHVSKRLWRTIRGLKDIGDKIGLLARGGSTMNDAEQDAHSDAAVAMAGLAGHKVDYNQSYGNPPTSQGNGDQGQELGVSPDDALQITNELSSLFELAGGYGASTPGADAFNYVGPSGDVGMPEGFNAFGNEPEFARIMNELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUD3</accession>
    <name>A0A1C1CUD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUD3"/>
    <dbReference type="STRING" id="86049.A0A1C1CUD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08789"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06047"/>
    <dbReference type="eggNOG" id="ENOG502QRUI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="360689at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="359" mass="38774" checksum="430DA25B2B31D409" modified="2016-11-02" version="1">MPPRLRLRSLAQLAELQLDRTSLTLPYTCGRCSRSYATAAAATTTIATTPAPTDAQIQSGFPPLSRYPPSQPPSHRNPAYRKSQLLRSYVSLLQTTPLIIFFQHSNLKAAEWVSIRRELASALRKLDAQLAAQGKPPEDLIGEYVKLQVIKTNMFEPALRIAEYFKPGLLDAQGQTHQEAGAGAGAVVVSPVSVPSEKEDPSLTHALSVAAYHASQAHRNEHVLTPLLTGSVAILTFPAVSPLYVKTAFSILAPQPGGVFAAPTRRANPLYHEPAVQDGVKKLMLLGARIDGQVFDMEGARWVGGIDGGIDGLRAQLVGMLQGFGAGVVQVLESGSRAVWWTMEGRRKMLEDEEAGPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUI4</accession>
    <name>A0A1C1CUI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Putative aspartic-type endopeptidase CTSD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CTSD</name>
        <name evidence="17" type="ORF">CLCR_08396</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUI4"/>
    <dbReference type="STRING" id="86049.A0A1C1CUI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08396"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05994"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000085">
        <property type="entry name" value="Aspartic-type endopeptidase (CtsD), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000060">
        <property type="entry name" value="Aspartic-type endopeptidase ctsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651054" evidence="15">
        <location>
            <begin position="18"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="16">
        <location>
            <begin position="89"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="399"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="399"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="445"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT52161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="528" mass="54332" checksum="9EA671E2F83356BC" modified="2016-11-02" version="1">MHRRWLSVPLLSSCVSAFYPYQSGDGGNDNSKRFIPLDLEPQTKDDSGVVTLDIKKVARRNNIFPVVTSTAANMPNAMAINQDGNDYTYFSTMKFGSKGQEMYMLIDSGSANTWVMSSDCDSYACQTHNTFGSEDSSTLKTTTQTWSMTYGTGEVDGVVAKDTVQLANYTVSMNFGLASTASDDFNNYPMDGILGIGRATSDALDSPTIMQVLSDQGRLAENILGIHLQRSSDGAKDGQITFGGVDSSKFAGKLSYAKTINSDSWQISADDAGVDGKAVGFQGKTAIIDTGTSYILMPPNDADALHQLIPGSSHNGERYVVPCSASANVYFTISGIKYSVSPKDYVGKQSGTGCQSNIIGHQPFGPNDWILGDVFLKNVYTVLDFDHASVGFGTKAGTTAANGSSATSSSASSSGTGAPSSSGSNSTVSSKPSATSGPASGGSAGPTTFATSTTRAGGSTANGSASGAAATSSASTGDSNGGSDSDPFSQAGDTGSSSGSSSSSSAVRSRSSSLIPIMALAFVVGFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUJ3</accession>
    <name>A0A1C1CUJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_11373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11373"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05998"/>
    <dbReference type="eggNOG" id="ENOG502QQA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="69"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT52157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="446" mass="47920" checksum="ECE1B9D97C2F6872" modified="2016-11-02" version="1">MAPGQVAAASTGRRQLLDEERQPLLQSSDWEPISSHDSHTQGGGNTPIPGDELSEGKPVRSWQHEDTFKLLSVILDFFIMGVCQTAVGALIPDIERFYHLSDGPTASLFVAHMGGYLCATVVIQHLHLRLGRRGIALLAPLFRLSAAALLSSGPSFNVALATYSLFGFGTGLADAGWCAWASSLPYANICQGMMHGAFSAGCVVGPIAALAVLNKGFEWYGFYCLAAALLSLELMAEGVAFRRDTAAKYRSTASESHDVRVSNPFRITATWMCGLFFFVHVGIESSFSDWIVLFMRRIRHADPLTASLSSSFWAGMAVGRLLLGFVTQFFGLRLSISRYILCSTILQILFRQITNAAFSLVFLGLNGFFCGPLFPSGILLLATKLPTKGHVGAVAAAAAMGHVGGALAPLAIGLLADRFGISHLLDVVPALSALMLVIWWAFSTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUL9</accession>
    <name>A0A1C1CUL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09144"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="184" mass="20884" checksum="62077C537781CB3C" modified="2016-11-02" version="1">MVFGHDVESALKDGTIHPSHVFEQPETDFDKDEDNQYGVKLRMENNSKKTRNVKNNAKKSQDELASLGVRYFARSNSHDRRPRMTIAAIDARRHRQLRYTNRSLVDVEQSNLDASRSLLNPATESYFVVVVVVVVCRNNASYDVWRSEQLVPSSRTSEVVEVWSMSRTGWVGTRVVSVGIVVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVS4</accession>
    <name>A0A1C1CVS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_09511</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVS4"/>
    <dbReference type="STRING" id="86049.A0A1C1CVS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09511"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04011"/>
    <dbReference type="eggNOG" id="KOG0600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000440">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000270">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="565"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="180"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="872"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="486"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="872"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="594"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT52623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="975" mass="109816" checksum="414E2435EEC7CC4F" modified="2016-11-02" version="1">MRDIHHTVRGIETETGTAKANVRIHRIEGIEGPRGLHPIEKEIIAKPVHRTGSGNFRGNDLLGKHTVEIRPFRLPVIYTQSAITHHPEKHSKTAPADVLTIHQVDRQNGGVRRVRLPPAAPDLVQKVGDGVAVENPLISTKGAHSLIGLVPRFENLIRVHFALLRQLLGLTSQTASRVLLGRGQPPDKKDNHSSKPPSVADDADDRSMDGQYPPHRGNYGTHRGQRPYIDARHQGYGGSPPYSSNSSYHGSPQANSPYHNQRGGWGGHGTMHNSSPPYRQNSFSGPGGMNNPNPYYQNQPGHYRGNQHSYQQSYRGRGHGPRGGHFQQDQRFNGPGGPRGRGRGGHFNNLQWTPPDAKEVVPQTETPQGNHTSHPQTSPAHSHTASHDGRENAAMEEENPYRPSKELQVEDQGTNRVNKTAQKTQGNDQPPSGPAASKFSFAFKSKAPPQAPAKPAADFNKPKGPFQPSENRPSVQPPSGPKNQSKHFERRDAERQANRPPQDRKFLPPQDRRHPNEASRQPQNDRRPDRSRSPPHKRAKKEVQTPRPTLSPEFAQSESIYYRKPGNESVVGAGTYGKVFKAIHIYTKDKVALKKIRMEGERDGFPITAVREIRLLQHLRHKHVVALQEVMVEKNECFMVFEYLSHDLTGLINHPTFKLNPAHRKDLGKQMFEGLDYLHRRGVLHRDIKAANILVSNTGQLKYADFGLARFYTKSRALDYTNRVITIWYRPPELLLGETQYGPEVDIWSAACVFVEMFTKKAIFPGEGGELSQLDKTYNVLGTPTRSEWPGIVDLPWFELMQPTDRRKRVFEAMYKDIFTPACLDVVQKMFKYDPKKRPTAEEVLNHEYFTTEQPAPEQPVELAQVEGDWHEFESKAHRRENDKREKEKRREEYQREREKRKARESGLPESEIKKARLDEPAGKETMPPPPACGDNSSTTALRGNEPPNDRSRDEDNDEGDSEGEGGAPMSMSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVT8</accession>
    <name>A0A1C1CVT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hsp70 family chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVT8"/>
    <dbReference type="STRING" id="86049.A0A1C1CVT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09847"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08664"/>
    <dbReference type="OrthoDB" id="4155882at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="68461" checksum="50034C92E0B44A40" modified="2016-11-02" version="1">MAKPDLPLSVILKQSDGHGGTLATVQAAIKRLDNTLIFGDDVELALQNREITAVDRMFYLTPMSHDKEMEAERNTNMNRPDDEELMHLFGKLKMEDQLSACGESLSATDIPALGLYSGLLAWVWRAAAKYVSGRYCDLNWHNFTKFTQEENFPPHGQDVKVALLIPSKSFSIVRHRQFMVAAANTAGIPNLRLVSEAAAALAHHITICLETIHPADLIGKTLMMLDCGPGSVDLEVWTILNVNPLRTGQYSRKESGYGRIADLDALLAHLRLVRGQQATKVSFGNEVDAEFEEQKRGPNGVEERYLSLPDLPNDRPSRLHGDAGIFLSESDMTAIYDNFLRPIINFVCQTIEKVAEAKRGDKDNGNIVDGIIATGEGMLNLYVQESFQRQMDILTEPSMRSKISMHFPTATQMNPHPLYNALTRPALGGVLLLADDALVAERVVDRSYFAAEFAPDRTTRTIWIRPQYFARKGHVLPTNARTPKEPYEVELLNDGREIFDLKVHILCSDTIAKDIVELDERESRKLLSDALPWVCTVTKEDLAGVPLTQAGAPNDTMTCWHVEYTVELTFDGRNLCFIATVPRSGRLGPNLETGDNPIEKFCEIDFEGGLRPVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVU0</accession>
    <name>A0A1C1CVU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytanoyl-CoA dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVU0"/>
    <dbReference type="STRING" id="86049.A0A1C1CVU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10308"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03921"/>
    <dbReference type="eggNOG" id="ENOG502RUKM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="349" mass="38472" checksum="E1195501ECECA860" modified="2016-11-02" version="1">MAPSAVEMPVIIPKSFSTPTRTNGSTHAGDLKGPSSPVPEVKSFDGASCSVEELVAAIRVAGGVVIRGLLNADEIASLEKDTRPWLEQDNAWGEGGGEGEFFPKETRRAFGMVTKSRTFAERIVGHPLWKGVTDALLSSNLHWNWIGEKNEPSVSRPQLNNTIVFSIGPGARDQALHRDDAIHHVYHPAAATHEIGRDAGIGFFVAGKKTTRRNGATRFIPGSHLWDYAAGPPREEQTFYAELEPGDGFMVLSGCFHGGSANKTNQPGEDGVIREEERLVYSTFMTRGYLRQEENQYLVNPVEKVRELPENLQELVGYGLSKPFLGWVDLKDPMLWLHPERPKKSGDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW26</accession>
    <name>A0A1C1CW26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_10513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW26"/>
    <dbReference type="STRING" id="86049.A0A1C1CW26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10513"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="66"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT52719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="276" mass="30869" checksum="C300E7106C11B52D" modified="2016-11-02" version="1">MSGLDKRRTFWPGKERRENINQHVLKRSWTELNEKIETPRKIDIAHSTSRISLPVHIAKLDKSPWQDYVRLLNICRGGQITVAYSSSRSQKLVAISEIPNCSREQLRALRPALHENIVGFTAAYFLDPSIYLVYELMPVSLIGILNTPLGPLQVEEIATVCQSVFRGIHFVHEQLGVMIGDLTAETVLVARNGVVKLANIGKVALAGSEKTLRRDVDAAGLILVRMLEPDTGMLFPKLLQLQRPSSCDANARDLIAGLNLLSTEDILKLRFSKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW57</accession>
    <name>A0A1C1CW57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW57"/>
    <dbReference type="STRING" id="86049.A0A1C1CW57"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10205"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04124"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26419" checksum="2E1B797BC6263FD1" modified="2016-11-02" version="1">MSEAAEIQRVPPDPEAQPVDPGPADDDIDSALGDVGASQPPGIVHMTNRTPALQGDDLLSTSSLASSVFDYIQEHGRRYNGYGERTYVLPNDEMELDRLDLQHHLLKMTFGDRLTTYEPEQSKDIHNVLDIGTGTGIWAIEYGGALEVQDISFRLRCDDGSLPEDSAFRRWAGCMLEASINLGCPLDSVDSVRELMIEIGFVDVEKRAYCWPMNQWPRDSRLKKIGETLLEIPCGAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWQ7</accession>
    <name>A0A1C1CWQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminodeoxychorismate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWQ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CWQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10623"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04236"/>
    <dbReference type="OrthoDB" id="5288718at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32180" checksum="A7DB88E0CA890FD8" modified="2016-11-02" version="1">MASSSISSSPNKDNQIHILTTLQHHFFNEEDAHAADDPSNLINTWKSLNATLLGLHARRILDAASALGWTAVLDSNLNLGPLIEQAARAQLFRPHGTTPPPERSSMVSARVRVLVSEAGLITIELVPLGPGSRLGPKLRSCIENYTTNPFGSTTTSKADIDVPVPPSRVVVDGKPTLPSVFTRHKTTRRTVYDEARGRADPPLRPTTLPTEAEVLLFNPAGEIMEASMSSVYFLRDGQWVTPRLGAGGMQSVTKMYALEKGWCVEGVVVKDSMREGEVIWLSNAVRGFFRGRICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXA3</accession>
    <name>A0A1C1CXA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuole-associated enzyme activator complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_09504</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXA3"/>
    <dbReference type="STRING" id="86049.A0A1C1CXA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09504"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04428"/>
    <dbReference type="eggNOG" id="KOG0212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="7">
        <location>
            <begin position="615"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="7">
        <location>
            <begin position="780"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="440"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="835"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="895"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="968"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="895"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="968"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1017"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1026" mass="112263" checksum="C525E3726EF6C6CB" modified="2016-11-02" version="1">MDSAVQRLLTDKLYDKRKQGALELERFIREASAAKEHDKIRKTIEQLCHDYAYAVHLPHARNGGLIGLAAAAIALGSDEVARYLAEIVPPVLACFTDQDARVRYYACEAMYNIAKVAKGEILVFFNDIFDALCKLAADSELSVKNGAELLDRLIKDIVSESAASYVSVLNFNEEGEPVEPDKDSTDLPTTFSLARFIPLLEERIHVLNPFTRTFLVSWLTLLDTIPDLELVHYLPAFLGGLFKFLGDPNRDVYVATQGLLERFLGEIKKIAKIKKGIAESRRSRAGKQRPASVADSTTAGGSQSNENAIEDSESGTALEEPNEPGESDGDWIPGQDAQVDHAQILDILLKFVDVSNSKESAPNLRLEGLSRQKEEEIGIVALRWIDSFFEISPEEILQFVPRLLSRVLPALSAQSEQVRTTASKVNRSLMDYIVTFQDQDDVPRDDQSALAPSDLTRATTREGEGSDKRQSGGTTKSPPSQAESKSEISLESSAEQDPSPPEVTPRSTAAPSPQPMADLDYAAAVNALTLQFLNEHEETREAALTWLIMLHRKAPKKVLAFNDGTFPALLKTLSDPAEAVVTRDLQLLSQISKHSEDGYFTSFMVALLQLFSTDRKLLEIRGNLIIRQLCINLQPERIYRTLADCIEKDEDIEFASIMVQNLNNNLITAPELAELRKRLRNPDSREGQMFFVALFRAWCHNAVATFSLCLLAQAYEQAYNLLQIFADLEMTVNMLIQIDKLVQLLESPVFTCKFHSAHENLGLASARQDLRHKAGADKMIDLRLQLLEPDRYPYLYKCLYGLLMLLPQSSAFGALKNRLNSVSAIGLLHTPPSAPTPRPSVVGGMSASSLPATTTGALNSTVTSRLRTRDAASATANDLKWPELLEKFKQTQERARRRNERLLRGDVDPETPASAAVDNGGRTSRASLRSAGAGEGEVLRAGNRLQSGLGRSLAPGAGSSLVKAGSGMTVGGSSGTGGAGPLAKTVAGTEDRSGPHKRGHSLAGFGKFASGIARAGGSRDRDNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY56</accession>
    <name>A0A1C1CY56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_10558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY56"/>
    <dbReference type="STRING" id="86049.A0A1C1CY56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10558"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00317"/>
    <dbReference type="OrthoDB" id="5578174at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT53350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="320" mass="36505" checksum="A04E2CCC4F9D195C" modified="2016-11-02" version="1">MNSQSRNRLLQALRAVPNRHTFTTTPVPPFRGTSVSLSQPFSSKACVSSLLPAAEDIHISKKRRYSSRAAPRFRHDDTRWVERDGRYNNASGRHAPRRDDTSPVRRDDGNDRADGGIIVTSDRQNFRDRQGRPWTKDSASTDQAVGTGAGTRAIGVGVGVGIGTSSPAKNKKSRTELRDLSVKPKKKKLEPWQAQKGALERKFGDEGWKPRKKLSPDAMDGIRALYEEDSERWSTPVLAEHFKVSPEAIRRILKSKWKPKNDEEAQKRKQRWARRHDRIWDHQAELGLRPKREKDRDVEDPDAFDEELRATEMLNMARKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY80</accession>
    <name>A0A1C1CY80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit tim-17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_10870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY80"/>
    <dbReference type="STRING" id="86049.A0A1C1CY80"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10870"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00422"/>
    <dbReference type="eggNOG" id="KOG1652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT53455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="156" mass="16486" checksum="678A1E04B433492A" modified="2016-11-02" version="1">MDHSRDPCPWVALSDFGGAFCMGALGGTLWHGIKGFRNSPYGERRIGMITAIKARAPVTGGNFGVWGGMFSTYDCAVKGIRKKEDPYNSIIAGFLTGGSLAIRGGYKAARNGAIMCAIFLAVIEGVGIGIQRLMAENTRLDLPPPQPPSEAGRVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYH8</accession>
    <name>A0A1C1CYH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative C2H2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_09558</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYH8"/>
    <dbReference type="STRING" id="86049.A0A1C1CYH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09558"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00554"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="810"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT53597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="934" mass="104129" checksum="97813B5C3FCD6F6F" modified="2016-11-02" version="1">MKDHQCSLCNKTFGRQEHLRRHEQSHQDPRFRCDKCSKAFHRKDGLDKHEQTHRSNGASLLQRGERACSTCALMKSRCTGTLPCARCGAKNLQCVYPTNNSRSVPSNPLGLQEQHGYDGRDSSSPLALQRRMEGEPHDFSGFAPVSAQAQYDRLANPPPHAPSAPHYLDAGTLGLQPSYGIQDAALYGSVGENATTPVANWTTKALSTINWLQADMTSFSDDDLNNLFGFLSSDFSFSPSIDLVSPAQQHDVETPANGLLSNIVAQQNPPQVVDRVNFQQTSPNPDSSDVVDKPTVESGEYYVDGDAGRLPRSKRRKIGSRPRFLEHVEDLEFSLEYHFPITPCPDSRLTLSDGVHDMLCTLHRQLCLETTLFKPFLPSEFPTRPALEGLLYNYFSQFDPTMPFLHFPTFKVESSPCVLLLAMMALGSCFVDSDETEIFTLSMHELVRRYLIVRNERKDWSPDNPQTLAQVHLLHAVGAGYTQVEGLHASALSSLYQATKFCRDSWAPQERANDSGRRHDNALPEWIAWVRNEEVIRTGFCIWMLDCMWAFHFQQPPHLSLDHVTAVQLPCPESAWSAKDVASWNQLAASGITGTPTLLEALRNLYIDKRHLPNLGEFSRILLIHGLIHRTREVEATVTQSLSKLEPSAQKQASHDIEPRSPVWPPSVPLFNRWRNSACDCLDILHWRANETIGAACGMEHPTVLHLHLARVILLAPMRDIILFSHHLIRSSKDAIRLFPCVSSAEAEEHCRLIQRWALQDQYKARLAAIHAGVLFWHVRLYSVNGFYEPTAVAFAALLLWALGAFSTKKPVQSRKPGPRARSGGTSLLSEPSSPSPDVCDIILIDRPTDDELVQQFVRQGDNMHANLTGVGDLFGPKGPRKVLAEGQKLLGTLRGWRGLTGYWIGVLSRLEKATAKFGVDSNPAGAEVTAPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYU0</accession>
    <name>A0A1C1CYU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10815"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00653"/>
    <dbReference type="OrthoDB" id="10435554at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="35"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="201" mass="23319" checksum="1D09B094A10A88BA" modified="2016-11-02" version="1">MADQVGFRIPESMAQILAGVMLSKELSISDGSFLASLFLRLPAELWFTLLAFTDYRTLVLLALSCKRMAVVVINTQAFRFAAATEEAEHAKLGHYEYLVQKAYLNLRIVRSKLHCSHHLCPFYMKPIWAWSKNVRRTAERLMEEQKKKNMEAKMLEDGQDAQALQQEEEKCEMSRVRIRTQTDNQIHNQLQRLFQPGSLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ46</accession>
    <name>A0A1C1CZ46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ46"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ46"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10017"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00739"/>
    <dbReference type="eggNOG" id="ENOG502S7KB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3539644at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="524" mass="56839" checksum="2517AAEA9C2541DF" modified="2016-11-02" version="1">MTIHKQYPPRNYETFADGAEALNQSPTSYRQGGDADKSRSAAVEARRLASQGSWADNFTGGTPATNRTPLASTVDGDEERDVEYPGIPQDGDPSDPPPVYTPSASTQTASQSPLAPASPVAARSVPAPVPGPVSTPNTQSPTRTRPAQSPFRPNDEEEGRSTLPEAVRQSQQGSPNRHYHDHDEEAEADSDSDTLPVFLQQQQQQQQPRRKWCRGPRKARSCGNRRHGFGHGNHDKHRARRFKKTCFFLLALLACLWLLIPGLCKSFKNDGRYDLPNFGEQPSQTPWPPEKREHREHETFRSITGTYQLYDLLDLSTTSGSITVTIEVQPGDKPAVLRLASQAGSVNVKMTSGGGLFRKRFVSEVAKSRVLQTEISSSAGSVSGNIVHGNGGSASISTNAGSINLDVYTVGVSELDAHSRLSTVTNQGSQHVKVYSDISNTEPIRALEASHTVRGSGSMTIEYPTEWEGMVHMTSYGSGSMAASGRGLVVRKESSHELYGYKGSKEGTKVEIAELGSGSVRFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZF6</accession>
    <name>A0A1C1CZF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_09968</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZF6"/>
    <dbReference type="STRING" id="86049.A0A1C1CZF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09968"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00837"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="41"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="87"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT53924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="574" mass="64771" checksum="D5FB19119637A8BF" modified="2016-11-02" version="1">MDRPCENATQDERGAGQKEDNGLLDITKLCCLVGVGKKLPETIELRRDPVKGEGLFARRDISVHEPICALPYSIFMALETEKLTTTCYSCLAVTSSHIPYIKGSAQEELSLKTCTGCSQVKFCGKACQTKAWKAYHKLECRIFALYHHKFPPMMVRAAMRVVLLKDKGLLSAQYWNALMKDLVSHEHIWMAAPENNITAMVRDIKFVTSSKLSLDTLTRLFWVMRTNSIELPVSVHGGIGTMLDPIFAKFNHNCDANVMLYRPWHTAKSGWNLESNPNSEQRSIFATVIPLRDIKKGEELTIFYSNPTLSVKERNAKHMMNYYFECSCSRCIDDTKAAAEVEDRLPDLSAQYVAWSQDVLGQLEQLQVDGEGGRLAYHKASQAWEDGIAQYLDFPELYTAGDFDQISLHLAVSGLQLGMFDKALISLLRSYFLIYPSRIPGRHNYSIIHIMFVMLETFDILLGIDCKDKTVEVVKPADVKGSLRRLSKRGLGIQTLLYWRLRISAHLRKCLEASAANDLLPLVARMQDRVLLHEGSSSGSDAACEGDRFAEDAMKKYLKLSEARWKVVLRETGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZU9</accession>
    <name>A0A1C1CZU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinone oxidoreductase-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZU9"/>
    <dbReference type="STRING" id="86049.A0A1C1CZU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10375"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00987"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="11"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="364" mass="39177" checksum="F06080CDF7CA13AB" modified="2016-11-02" version="1">MKAIQVTKYVSGPQDLFVTTLPTPAPHPTKYLIKIRACGTNFFDLLQIQGKYQHQPPLPWIAGMEFAGVVVATPTTREGSKSAVASSLDGTVSTQTNHQFKVGDRVFGATHGAYASHILADEGVLFPVPQGWSFADAAGLYVTTPTAYGALVTRAKTQPGEWVLVHAGAGGVGLSAVQVAKALGATVIATAGSERKRQVCLDYGADYVVDYRDKNWPQRVIGLCEQHRTGNGKQGVDVVYDPVGMIDPSMKCIAWNGRLLVIGFAGGTIEKVALNRVLLKNISLVGLHWGMYATKEKETVPQVWKGIFDLINSGKLKGITYTDKHYKGLEEVPSALIALGARDTWGKVVVELGENEGEEGRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZY1</accession>
    <name>A0A1C1CZY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_09712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZY1"/>
    <dbReference type="STRING" id="86049.A0A1C1CZY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09712"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00967"/>
    <dbReference type="eggNOG" id="ENOG502QQ71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="239"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="432"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT54067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="719" mass="74383" checksum="510A32E6A03BE2B5" modified="2016-11-02" version="1">MDFTQQTTTPSDWILADYAKVDYASSNGANFTISKRHEAPYIWSRFYVHFGRIEVVMKVASGGGIITGAVMMSDDLDEIDWEFSGNNFGQGRGSVLTNYFGKGQIGWSERGAYPAVDAPQDKFHTYALDWQPDRLIWSIDGVPVRTLNNNGATTGSYQYPQTPSRLHLGMWCAGDPDSAPGTVQWAGGYTDFSTAPFSAYVKSVKITTSNTCSSYKYPYPFDGTYKSVQCSNQTVTLPCTYAVVAGDDGDKIAKKLTVNFDILKAANAGVDWDKLLIGQVLVVPGGTCAASSTTTSMSSTSSTPFSATTVSTTSSPILTTTTSTFTAPTSPSTTTTSSNTAASTSTSAALSTSSTTTMTSSVMTTSITVSSPGTMAITNPTALSSSTISVVVPASTATTTASTSPTSTSSSTTAVLSSSSTSSVTPSTAPIQSYMVVAGDFGWAIADKNGCSFDALNAANPDVDWDNLQIGQVLNLPGQIVISSTVTTTPSVSTSGVVSISTTTTQPSSSSTVSTPSASLESSSSSMSALTSTFPYDSASSTVNTSSGTASSTASTTTSLANTGTPTPTSSGPTSTSASGPVVTTTSPTANSSSRTNAVNPVTPSPLPTPKMFCNQDNCLRNMIDPRYSSSMRNFCSKYTTTNSNTTPLPTFLGGCSADAKRVSSACSCLITSFGSGTTTASSSALTASASRSGSPASGRQVPSWLLKRSPLRWNRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D007</accession>
    <name>A0A1C1D007_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_00155</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D007"/>
    <dbReference type="STRING" id="86049.A0A1C1D007"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00155"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02602"/>
    <dbReference type="eggNOG" id="KOG0205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="742"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="769"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="803"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="843"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="871"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="917"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="75"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT54097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1001" mass="110483" checksum="6FE0F4842DB53119" modified="2016-11-02" version="1">MAEKENKDLENGDPKRERISFADGWDPDKDEGEYANLIRYISTYRDRRFSKAPSQVSGDDVADASQKKKIPFYKRWFSRSSGPGELFEVPEEWLNTDIKTGLTSAEVEARRRKTGWNELATEKENMFLKFIGYFRGPILYVMELAVLLAAGLRDWIDFGVIIGILMLNAVVGWYQEKQAADVVASLKGDIAMKAEVVRDGQQVEIKARELVPGDILILEEGSVVAGECRLICDYDNTAGFEEYKEMVNDPEGYHSKNHTDSDDDEEHHIGHSIVATDQSAITGESLAVDKYMGDICYYTTGCKRGKAYAVVTESARGSFVGKTASLVQGATDQGHFKAVMDSIGTALLVLVVFWILAAWIGGFFHNIKIATPEDSSVNLLHYALILLIIGVPVGLPVVTTTTLAVGAAYLAKQKAIVQKLTAIESLAGVDVLCSDKTGTLTANQLTIREPYVAEGEDVNWMMACAALASSHNLKALDPIDKITILTLKRYPKAREILQQGWKTEKFMPFDPVSKRITTICTLKGEKWSFCKGAPKAVLSIAECDEATAKHYRDTAADFARRGFRSLGVASKRGDEPWKVIGMLPMFDPPREDTAHTILEAQNLGLSVKMLTGDAIAIAKETCKLLALGTKVYNSQRLIAGGVAGSAQYDLVEKADGFAEVFPEHKYQVVEMLQQRGHLTAMTGDGVNDAPSLKKSDCGIAVEGATEAAQAAADIVFLAPGLSTIVDAIKVARQIFQRMKAYVQYRIALCLHLEIYLTTSMIIINETIRTDLIVFIALFADLATIAVAYDNAHYEQRPVEWQLPKIWVISVFLGLLLAISTWIMRGSFYRSDGGLVQNFGNVQLMLFLQVSLVENWLIFVTRGGQTWPSWKLVGAIFAVDAISTLFCVFGWLAGSKDELFTTPYDAFTEEHYSRETSIVTVVVIWGYSLGVTIVVAIVYYILTSLKWIDNLGRATRSHADTTMENILGHLSRVALEHETDVHGKSKWVLGSKATGEEEGTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0F0</accession>
    <name>A0A1C1D0F0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0F0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00338"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09457"/>
    <dbReference type="OrthoDB" id="202195at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="136" mass="15727" checksum="31DA1EC12C501A57" modified="2016-11-02" version="1">MNTARLLRLQPLRSLAFRQAAFRQSAQKQTGRPFHNSRTLFRSKASTNTRFQSCCEDDQSAHTITQRIRQLKKVPPELLPLGVVIAYVTPVSEYVRSIYSYTRPARFALFAAVFAMGRKLWTDKTLRLQRSAQKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D120</accession>
    <name>A0A1C1D120_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Palmitoyl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_00863</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D120"/>
    <dbReference type="STRING" id="86049.A0A1C1D120"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00863"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10104"/>
    <dbReference type="eggNOG" id="KOG3016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="41"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="4">
        <location>
            <begin position="199"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT54553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="314" mass="34700" checksum="26C0E0509F5E5FE6" modified="2016-11-02" version="1">MGSSEPPKPSAARLDFETHLQLKETAPDVFTAIHTPWLFNITNTMPGPLMMAQAASAAWKTVPDGFMLDSLQTHFMLAPNPAIPLVYKVQRIGNGRRFAVRQVAVEQADRVFVAVTTSFVNNAPWSGRAMTHAVPMQIARHGERSGWKITLDDFEDMRTERGPFMKFERLPLVHQDPKNPATTIAPVVAQIDPPIAAPRGAAAHVLAVVHASDYHVMDCPLSIHGVPHGLWPIGDVTKTALPASMKIMTSLNHSIHFHTQDGFRADELLYVEVTSPWAKDGRAMINSRIFSRQGLLIATVVQEAFYVFKESAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D129</accession>
    <name>A0A1C1D129_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_00838</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D129"/>
    <dbReference type="STRING" id="86049.A0A1C1D129"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00838"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01687"/>
    <dbReference type="eggNOG" id="ENOG502QRES">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15153at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1500">
        <property type="entry name" value="Glycosyl hydrolase domain, family 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049166">
        <property type="entry name" value="GH39_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000514">
        <property type="entry name" value="Glyco_hydro_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051923">
        <property type="entry name" value="Glycosyl_Hydrolase_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12631">
        <property type="entry name" value="ALPHA-L-IDURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12631:SF8">
        <property type="entry name" value="ALPHA-L-IDURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00745">
        <property type="entry name" value="GLHYDRLASE39"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 39 N-terminal catalytic" evidence="5">
        <location>
            <begin position="73"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT54424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="537" mass="60509" checksum="CC6764A9F1A9C6C9" modified="2016-11-02" version="1">MSIPVAINVFGNKPVEPWRQIYRFYGTDEINYVYMKDGRKLLEKLGSLGPHQAWFRAHSQFVTGEGVHALKWGSTNAYTEDKDGNPVYDWTIIDRVYDTYLEKKLKPYVQFGFMPQALSVQPEPYQHKWTPTAPYGEIFTGWAYPPKDYAKWGELIYQWTKHCVERYGISECESWYWETWNEPDIGYWQGTPEEYNKLYDYAVEGVRRALPSAKVGGPETTGRGPEYLRGFLQHCLDGENPATQGKGAPLDFVSFHAKGAPQYQEETKSVRMGIAHHLREIDTSFGVIASFPKFKPLPIVLGESDPEGAAAAQGPQLAYRNSTLYSSYTAASFARKHLLSEKHGVNLEGVVTWAFEFEDQPYFAGFRVLASNDVDLPVLNIFRMFARMEGERLASTSSQQVPLQDLLQNSVREDADVGAIAARDGQTVSVMVWHYHDDDLKGPSAAVDLTLEGVGWKENSTLRHYRVDETHSNSYTVWKSMGSPQQPTAEQYAKLQAAGSLAEYTGPTKLEAQSGVPKLSFDLPRQGVSLLVFENVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1B0</accession>
    <name>A0A1C1D1B0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 25 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1B0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03007"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04757"/>
    <dbReference type="eggNOG" id="ENOG502S3CD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="38785" checksum="62F01D45CF28B779" modified="2016-11-02" version="1">MLRQLGTFRVHANPRLHILPAAIILLLVFILLPSRYSSNVRLGQLFGVSAVLPRQAAANATLGFHKLIALSSKPSWRTRGLQAAANLTGLDFIIPPQPHNPEEFVVAFEDIGLGQTTTPKHGSASAWVAHLDLLKFVIASGFETTFIVEDDVDWDVRIKDQIKLISDNVRNYTSVPESDPNPYGTDWDVLWLGHCGSAIDDWIPPGVIYADDTRIPIDLYASWSTGFLRERLPEGHRIIHASTMTVCSFGYGVTRASAQKILTLLGRGADEAFDVALSHQCRERALRCLVVNPQIMHHYEPSRDLGYVSPVDSGDGEGEPADETEFEFIKGKTLNIVKSARCQALFNDTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1Z2</accession>
    <name>A0A1C1D1Z2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1Z2"/>
    <dbReference type="STRING" id="86049.A0A1C1D1Z2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03046"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04775"/>
    <dbReference type="eggNOG" id="ENOG502QVP1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5556956at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027973">
        <property type="entry name" value="FSAF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053030">
        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="289" mass="32217" checksum="17FFAC4D7500B99A" modified="2016-11-02" version="1">MLGKRKRQTATAPRRIARLDDEKPDVEPASASDHEVFRRHFESVFEPIPEFQTATSPSPSLDHADDVGEPSDEDSEWEGLSESESGLEPDNATIQIVEHRAEISAAEDFGLQRQQYKAFMSSRPPKEVGRVARTQSAQEVDEEDASEALNLKHDLDLQRLLKESHLLEQAKAASTLGSHRHKALDMRMQTLGSKGSVFHQEKMPMAHRRGILAKAAARENGRRKEASENGIILEKAVAKSRTKELRRERAVDVPAVGKFRGGTLRLSKRDVLDIQGPGRSGPRGKSRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D214</accession>
    <name>A0A1C1D214_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPL19B</name>
        <name evidence="7" type="ORF">CLCR_02871</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D214"/>
    <dbReference type="STRING" id="86049.A0A1C1D214"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02871"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04897"/>
    <dbReference type="eggNOG" id="KOG1696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="6">
        <location>
            <begin position="63"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="255" mass="29981" checksum="6CE4AB1DC2A9EC22" modified="2016-11-02" version="1">MTCTFRWLTLRHNGRLTIHFQKRLRDYDGLRAKKIKDLTNGTSVPTLIHRRRPSHHPRIKMVNLRTQKRLAASVVGCGKRKIWLDPNEVNEISNANSRQTIRKLVSDGLIIRKPVAMHSRARARELNAARRIGRHRGFGKRKGTKDARMPSQVLWMRRLRVLRRLLVKYRAAGKIDKHLYHELYQLSKGNTFKHKRALVEHIHKAKAEKQRERVLKEEMDAKRAKTKAARERRQERIQTKRNALAGEAEEETKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D276</accession>
    <name>A0A1C1D276_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HBR1</name>
        <name evidence="11" type="ORF">CLCR_03144</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D276"/>
    <dbReference type="STRING" id="86049.A0A1C1D276"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03144"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04880"/>
    <dbReference type="eggNOG" id="KOG3347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT54785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="191" mass="21366" checksum="D94D85E4B378E1EF" modified="2016-11-02" version="1">MRSLPNIIITGTPGVGKTSTATQLLSLASSSSPAINLRHLSINDLVKSRECHTGFDEDLQSLVVDEDKLMDEVEKEIEDGEGQGGWVIDWHSTAGFAVRWVDLVVVLRCEETDVLFDRLTARGYKDNKVQENMDAEIFGVVSEEAKEGWEEEGQVVELKSVHAEDIEENAERILQWVKDWVKDHASLGKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2X7</accession>
    <name>A0A1C1D2X7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2X7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03229"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT55084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="72" mass="7525" checksum="3FA01405F7B3B32C" modified="2016-11-02" version="1">MSRRNGDGGGMGVLEDEVCEDEKGEGRGIAECAGRKALLRWFGQNLHGPGKLTQPPIVDHGTQAAAQPSPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6C1</accession>
    <name>A0A1C1C6C1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TEF1</name>
        <name evidence="13" type="ORF">CLCR_00608</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6C1"/>
    <dbReference type="STRING" id="86049.A0A1C1C6C1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00608"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01023"/>
    <dbReference type="eggNOG" id="KOG0052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT44085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="459" mass="49796" checksum="D4103A72F10623FC" modified="2016-11-02" version="1">MGKEKTHINVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYFVTVIDAPGHRDFIKNMITGTSQADCAILIIAAGTGEFEAGISKDGQTREHALLAYTLGVKQLIVAINKMDTTKWSEDRFNEIIKETSNFIKKVGYNPKSVPFVPISGFNGDNMIDVSTNAPWYKGWEKESKAGKATGKTLLEAIDSIDPPARPTDKPLRLPLQDVYKISGIGTVPVGRVETGTIKAGMVVTFAPANVTTEVKSVEMHHEQLAEGVPGDNVGFNVKNVSVKEVRRGNVAGDSKNDPPKGADSFNAQVIVLNHPGQVGAGYAPVLDCHTAHIACKFSELLEKIDRRTGKSMENNPKFIKSGDAAIVKMVPSKPMCVEAFTDYPPLGRFAVRDMRQTVAVGVIKSVVKSEKSGGKVTKAAVKAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6C6</accession>
    <name>A0A1C1C6C6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GAE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_00112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6C6"/>
    <dbReference type="STRING" id="86049.A0A1C1C6C6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00112"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02019"/>
    <dbReference type="eggNOG" id="KOG1087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAT" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="6">
        <location>
            <begin position="254"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="39230" checksum="12DAE163701FF0FA" modified="2016-11-02" version="1">MCEEESDDAEAVAKLLEINDSIHRTIERYKLMKVGDIEAANRIAKGTLGTTTGVGKNAANELSLIDFDPEPQAAPPAGVSSSSGTNGSLLDTGTEASTTQPRPKTVEDDLLGLSLDDASAGSLGAISLGPSTGFSAPSGSIFSNAPSSLLSNQPSVPHTSPQPSPKPNYDAFASLTSPPPTSKSATPVPMAQQQQPARPSTQVLADPFAALVSASSRSSTPSMPTNISQPASQPSAAVNQGSLVPAEDDWTFESALPEPQAIKVLSGSLEIDFEARRPAGQAVIQITARFSNTTQQRITGLHFQVAVEKSYTLQLRPQSSRELAPTTRHAVQQEVLLNGVPVGKGNQVKMRFKVSYALDGQPQEQQGNVPPLGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7M1</accession>
    <name>A0A1C1C7M1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell morphogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_05335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7M1"/>
    <dbReference type="STRING" id="86049.A0A1C1C7M1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05335"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07159"/>
    <dbReference type="eggNOG" id="KOG1825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="371"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="992"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1463"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1762"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="1975"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2410"/>
            <end position="2456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2529"/>
            <end position="2641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2418"/>
            <end position="2440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2533"/>
            <end position="2542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2549"/>
            <end position="2559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2582"/>
            <end position="2595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2626"/>
            <end position="2641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="2641" mass="292758" checksum="4F06A0933F34FBA7" modified="2016-11-02" version="1">MLPDAQSASNEPSVYTLDGPGPEQVSQPLSNSRPQLHTRNTSVTRGRPQQSAPQAYGPNDTTSSRAGSAQPQPIGSDAGVNARGGPAVDTTGLQRRTSNSYGHHRQTSVIHGLQHSRTPSFNSPSSASPLTPESLLSAAGYARYPTSSRRGQYSNASAETSAYTSPVSPYQSHGQGHSIDSLIDARASGPEPASSSSQNRRRKDHSRTRRGHAYNSSSFHQQPEPRTPGEYALHHLFHAFVLRADQRINHCLTLLDTSPAPVEQACAPGVDAAFDQLIVSLGHISRLGPKPLVDSLMLWRKGKGDAAANLKKQVYQQRIQAGTPTASLPPSLGRRHTEPLQVPSEAGLSHVGAEGASAAEDPLTQEYLFADRRATISVYILCRVLIAIFEQSTLAAITQDLANKLEDIVFTQIREVEPAQILTSTIRLANWRIYGEVLGHMSRLDFVNVTFRFTQQLDQWQQDVAKSSGTAAARDLESRIELLLLGMRHLHIPPTREAAFAVADFLRTLAALFSDAHGPRVKQAYCQLFERLLTAVASNPDCFQNVPKWKDFIETINSRLGNMLVKVRHWSIGFPVSILLICISPTESFSVQWLPMISSLAPKLKDRSTRALALQAICQLVWTYLVRVGDTLQVKLRRLEEIIKITIPQGRKTHVVSDPATANPLVQFIRILGFTSQELCFRAVIFPLLHYDLFQSSRTLRIEQIEPERMVIGIRAFLVLISDLEKGDTRRPPFPAFNTHTPTVDGLPPSPMSMRAILGIDSPVQSICEAESPSSLPVNVSALDENAQQYYLQFCQILGKITILCDNTFGGQATLNEKFSSVANVTPKTPLADAFTLARNQEPIAPDQRQLYYELLHVAIQALPRCFTDHIPLNPLINLLCTGSAHVQANIAASATQSLKAIAKQGHAQAVAIAFPRFIFHYDSQYSTMSDEGRLGPAHIETTLTLYLELLQIWMEQLKQKAVASSVEARDRSAGGPNRALQMELTNAIPHVDEIEAYGLFFLCSQSRRVRAFAVKVLRLVVQFDSVLGQADSSRIIKLLEDQSSTILDLHDDALNVAERSRLQKDKRVGPGQSTLIEICSSEVSYDSTLWFKAFPNLIRVVFDACPNAIALCRGTVTDRLVMMQNDIEAFSDAAGATAAMYEYRMQGRSSATSAEVLFDQWKLYLIMACVTLSSPGAQSQSQLADAAHARKTSKSTVPAQDKLSSARALFSAIIPMLGAAPDAIRDAVVSALGSINRKLYRTLLESLQYAVIKCNEEAKARITHHRTPSSPQRSQQTERLRTEVTHVYKLTASFLRHEDIYNDDWILNNLVIYTRDLRIFLSDTDVQNDWRFQKLRYHFCGLVEEVFEGVNRSQTPSRWMPFESRKSAFALMEDWCGYSAEQTSIDPNHNNARTVQDRINASAATEKEKNNLRVAALSAMATLCAGTISIRTDSNAILSFNLPRMLSWIDTIFATNNHKMHTIGRRALKLLLMHNPEHLGIVEHAVEQCYRTESPMALESYFGVVCDVLIQHEDYPVPFWKIVSIIVFTLGNENREIRMKSAHLIRTLDERQHKRTNLQEFDISISDKTRAVYKLAQFEYSRRLAKANSDIAFMVFSEFSLHYKSARNDHQRNMVVAILPWLQTLELQVDSATGSPTAVSYMLLANMFEITICSSSAMHNEVQALWQALATGPHAGNVQMILDFIIYLSLDRRDQNFVEYAKQIVVYLSSTPAGSRVLEFFMLQLCPKNMVNDRKHAEVVMPDTRSLPYVADLTSLLPMGTKQVSLIFLVDLMVAPVTLVRDEAAKLIHAVLILWDHYTASVQEQAREMLVHLIHELVTTKIEAQTLSSAKSKIESLVDAIRTNSPRISWSYESNTRKDEDDGGSRVPPAMTALTTEIVSIFNLAFDNFSDSWAKEALHWASICPVRHLACRSFQVFRCISVSLDARMLADMLARLSNTIADEHTDYQTFSMEILTTLKVIIGALEPKNLLRYPQLFWTTCACLNTIHEREFYETLGMLEKFLEKLDLSDPDVTEAMMKGLPGKWDGGFEGLQPLLYKGLKSADSLDKTLLVLQQLAELPDCQLVGSDNRLLYCVLANLPRWLHTFDQDATNAAALTSAQTLARIASAEGHEPLSICLARYANNDITSQEMLTATVKSLKAAYFPLCDASSLIFMIGLLTNKTPWFRVKLMDILCELIPIVNMKSPSITTHGPDLISPLLRLLQTEHCTQALEVMDYIMEVAATPMEKHHMRMSMASGSAKAIRKEYERTQSLYGIPHSSGWSIPMPAVYSGMTRHNVHAVFYTCGDSEFLKDQETSTPDVEFQGDDGYTDSYFPPQSRAETIRTLEAADTNVSDLVNTLDSLDDFFDDVEADDVLTPMGTSQLMGSAISIPTLTEQNTDLYDEQTAPILRQSLSRTMPSTNVQDGFTEAGPLPGITHQTQPSLSSQNYSTSAQTSFSSIDELGGPGPSMPNSTKKAALQTSISPVSHQRPGLHARSITSPANQFPFSQPAASGLATMPENFLFRSQDDFAEQYDEAVLSDGENSPFPLLSMTMSNQSKSLSGPGPSEYQTTPTSATETGGAFSLQGMRRGMRRLTGGKSESQKEKEKSKDYARIRGQSGGPNLVPPAMQSPRVPRVPSEYLTGGASNINSVSPTASPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7P3</accession>
    <name>A0A1C1C7P3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA mismatch repair protein Mlh1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Mlh1</name>
        <name evidence="8" type="ORF">CLCR_05497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7P3"/>
    <dbReference type="STRING" id="86049.A0A1C1C7P3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05497"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07161"/>
    <dbReference type="eggNOG" id="KOG1979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03483">
        <property type="entry name" value="MutL_Trans_MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000033">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="253"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="668"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="764" mass="85291" checksum="55F221372E06DB0A" modified="2016-11-02" version="1">MADTMDVDSEPPRGVKRTAEEAGLPPEAPRRIKAPGEIIVAPMHALKELLENSIDAGSTSIEILVKDGGLKLLQITDNGHGIEVCTLPSHYHVASDTDQRDDLPILCERFTTSKLKNFEDLMSIGTYGFRGEALASISHIAHLRVTTKTANSSCAWQAHYQDGKLIPAKPGQSAEPKAAAGRPGTQITVEDLFYNIPNRRRAFRSPSEEYAKVLDVITRYAVHREGLAFSIKKHGETGAGFSVAAAATKVDRIKQAYGGTVAKEIMTFSTEDSRWGFKASGYATNANYSNKRTTLLLFINNRSVESSTVKKAIEQTYQLFLPKGGHPFVYLSLEVEPNRVDVNVHPTKREVHFLNEDEIVELVCANIRENLAKVDTSRSFKTQTLLPGVPPMTPMNQRLVPGDATPPTDDSAARKPSTTKKPYENNLVRTDSKMRKITSMLPPALMTSTSQDDPPAADEIQYTTTDREQIQIRLTSVKNLRAEVRESMHNGLTEVFASLTYVGVVDSTRRLAAIQSGVRLYLVDYGMASNEFFYQVGLTDFGNFGLIQLQPAPHLRELLDIAAEYQFEIDPSCVGLNKDQIVDKVYKQLMQSKEMLAEYFSLSITDDGQLETIPLLLKGYMPCMAKLPTFLLRLGPFVDWTEEEACFRTFLRELASFYVPEMLPPFQEKADKGKGKARDEDMEDSDPAQDVQPHAETQTQDDTENSQPDPDNEATERRSKEIEYTLEHVLFPAFRSRIVATQDMLKGVVEVANLKGLYRVFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8Q0</accession>
    <name>A0A1C1C8Q0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8Q0"/>
    <dbReference type="STRING" id="86049.A0A1C1C8Q0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05784"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07574"/>
    <dbReference type="eggNOG" id="ENOG502QQEZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="53024" checksum="0055BDC97DA090BD" modified="2016-11-02" version="1">MLFPTSTSSLRHIPGSRRKDKVIDLEVARSTPSPTVDPSVHVILVGHSMGGIVAAETYLLLASEQPIPAASSAQNPERPNFPSNTTLGSTTSTSHPTPSRSDPASHRHAFMFPHIQGILAFDTPFLGLAPGMVAHSLEGGHKVVANAYNTYNEVTSMFSWGTKSEPNVASAGAAKSRNMQALPAPVSASTGDAAATPKWQSWGKYAMFAGAAGAVVAGGAAALYSQREKLSAGWKWASDHLLFVGELFKPENLRKRVESIENECQERGGGCANLYTNLGQGARGGYGITESVAGKERTFCNLPVHVSRDRKEIKQGADESKPSRFKWIKAVNEKAPDETSAHVAMFLPRDNPGFYALGERAKECITSWVDQSWYGTSNGPTFLKPNHTIGLGESPSSGWVKPDADEIRAQERAKDRYGKSYQHPEPDVDGTLGKDWDPVDVRRGKDGIDDFLDDEDVRMRDEELDDSVIIENKAAEGEIPLPKPRSNTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8V2</accession>
    <name>A0A1C1C8V2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell pattern formation-associated protein stuA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Stunted protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_05857</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8V2"/>
    <dbReference type="STRING" id="86049.A0A1C1C8V2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05857"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07645"/>
    <dbReference type="eggNOG" id="ENOG502S0ET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5346159at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990862">
        <property type="term" value="C:nuclear membrane complex Bqt3-Bqt4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044820">
        <property type="term" value="P:mitotic telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000002">
        <property type="entry name" value="APSES transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037548">
        <property type="entry name" value="Bqt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044:SF1">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0183">Conidiation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="6">
        <location>
            <begin position="64"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="351"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="419" mass="45023" checksum="78EFC6E659DA0D96" modified="2016-11-02" version="1">MARSLPVKRNPLVAPGSAPAHEELLARRRLGKTKLSVKPGQIGTSNATKAENLGHFEYAHLRAPLPEDLTGSEIFASQSNQAHPETYFLMRRSKDGFVSATGMFKIAFPWATHAEEKEERDYLKGLDATSEDEVAGNVWISPDFALELAEEYGLSDWIRALLDPTEITQTPSSTKKPIAAPPKFDLPDLPPSKTKGPASTKGARSRRTRSVSPSKAGTPARAKASPRKRQTKAQKEANIAHAEAASASLQSALDDAASVAQSVLDDAASVSVEGTDSKLASPETTVLPSPPTTSAESETVKVEVDQTVELEGNTQITHTNVTVEMPAGSPELPLPEDTEKMLETARKMVEEAKTLESSPKVSKKRKAAEAEPSDIDAELPAQPAKKARVLEEKLKREKVRTRAVLGVTATLAIAYVLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C925</accession>
    <name>A0A1C1C925_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C925"/>
    <dbReference type="STRING" id="86049.A0A1C1C925"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05510"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07619"/>
    <dbReference type="eggNOG" id="ENOG502RYID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3034003at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650650" evidence="2">
        <location>
            <begin position="21"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="629"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="779" mass="84860" checksum="371EB048DDD6BAEA" modified="2016-11-02" version="1">MTWMRPLALGLVAIAAVVTPLGLYDDIVPSKTPQSVAFAYVQDPGPMGYGTPGRSDLGFTRTCGNLLPLQCPGTTVEITYFENATYAEANITNDDYDTRIPRVLADLYQSGLQQQPQSVSSFFDIQARYYTYTFQTGVAHGAKYIAGAFRYLSNMVLNNAVEPVEGLVVDTVTGGIAFRNHSVPQGISLGAEWTEDLLWVEPETACADTNISVEFRIPLGNGFTVLTDLANISLVDNGGFANLVQEYPYVNVTDAQNDPNLEGRAYKAAWLVNVYTMLVMNLTRPNPDAFGYMKSKVGDRHPVNKYQTPGAKLNGIYATNLWQSLLDPEAYISNYTLDDAPNTNYSNPFGLSFMNYSDIATLCSGAGGRDLANLTNVHVECGMIYGAAQRRDGSKSLVLEPETWWTQKVYTCATAMKATVKEVRFRWNTTSLTGNTLKSLTVVNVREKAYADKESMPLWGVETPGYELQDVSQLWGLIAPDLAHSVNLSTIRAPHLYIPGYGGSGILSAAVATKDNLPAHEGLSSVMGGIFQTYSNGDYADYSGGTNMAMYKRWRDYSTSAAAMGTIPNLIWTDLAANMLVGTRSWDSGTGLPPNLQKRDAASASSGETGQPLVPVTIYERQIRYHWPFAVPALLALLLFVVVLLAALLSVLAGKGVPARVRHYLFHLSSGRLLGEIHYPGECDKLAPTNQWLARVGKRPSDLHTYVQHTSGVGAAPSPFLGGQHDHMAGGVPGNEKDNGMNVDTHELRRVATPLSESDAMLGQTRLYAEDGRQRSQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C946</accession>
    <name>A0A1C1C946_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD domain, G-beta repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_05383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C946"/>
    <dbReference type="STRING" id="86049.A0A1C1C946"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05383"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07679"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07680"/>
    <dbReference type="eggNOG" id="KOG0283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000697">
        <property type="entry name" value="WD repeat protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="397"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="466"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="506"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="742"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="828"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1038"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="755"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="833"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="923"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="968"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1038"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1072"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT45007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1121" mass="122035" checksum="B9EFC039762834E4" modified="2016-11-02" version="1">MQSDLILLGIRPVSSTPTGPLEPQFSFSSSFIEILDAWRFTSFACRNMAMVAAGGKSDGKGMFLAAIQEAAESSSPAPTLSPGSSPSVTLRKVVVLNHGTGQQQQPSTVAADSGMSLVILNQPLSVVFEAAHAPCSKPTGSGAGRSCADCAFPTSDANVGNGLAHDYNRGLRTQTGDFSGNMSPVVAGSSSELLPAAEGVLDPISRVLYTYPPMCRSPAHPNVQQILERTQSQSKVPGASQGGVSARSPYADSGYSDDQYSAILKPEPNSLRRVDSGTSGKEKKKGVSFLSRIMGNRKRDSFELHDDNASEIGSEVRPAGVEAEVFSQPVGFIPKFPAPPRYIKVKSQYRKQKDFDRLFLAQIILNAPSSKGRKAEIDSKIHDIGETPAAAAPAPPRNSANYAIWAMEFSRDGRYLAAAGQDKKLRVWEVISSAEDRDNEEKLSETNNENVKLNAPVFKSKLCREYDGHTSSILDLSWSKNNFLLSSSMDKTVRLYHVSRAECLCAFKHNDFVTSIQFHPRDDRFFLAGSLDSKIRLWSIPDKNVAYWAQVPDMVTAVAFTPDGKTAIAGCLNGLCILYDTEGLKAHSQIHVRSARGKNAKGSKITGIDTIALPRESAQPDVKLLITSNDSRVRMYNLKDRTLEVKFRGNENSCSQIHASFSDDGKYVICGSEDRKVYIWPTSVNERPDNDKRPMEVFEAHSAIVTTAIMAPEKTRRLLAQSGDPLYDLCNPPPVTLVSRADSVISSRAPTNNSSDEKQIKEEARLSESPRRAPETPAYLGRHSHPGGQIIVTADYTGQIKLFRQDCAFQKRKAETWDTSSTFSRKMLGRSGSVATRNSVATSPSHRNSFAMNPKTQSTDRILSWRNSVSPTDSGHNNSSTSMLEMRGSLRENERSRSASPRKLLGHRLSLHRSSPSRKDSLASPSSPEYHSPLQQTQNGPAITVQSPLAQSPQSFHSAPRSPDQEMLSPQNSLQPLPSNPSPSDLPHDANDPLFLMGQQSYMAWDMKHTLMPMAAHVPRTPGLLGPDGNPLSRAASYVSQLSSDLTGSERDPSPGGSMGDDEQRASAVGAKNRKSSRSQRRSSAGSENDLKCKKCGGTTFRATRTEKGQSFRCKKCGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9C2</accession>
    <name>A0A1C1C9C2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rki1</name>
        <name evidence="9" type="ORF">CLCR_06117</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9C2"/>
    <dbReference type="STRING" id="86049.A0A1C1C9C2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06117"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07732"/>
    <dbReference type="eggNOG" id="KOG3075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT45059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="306" mass="32837" checksum="274D23646AB24024" modified="2016-11-02" version="1">MAAEIEAAKQAAAIEAVKNHFPLNPRFVGIGSGTTIVYVVEAIKTCGVDVSRVGFVPTGYQSKQLIINAGLVPIEFDALPDDVLIDIAFDGADEVDEELNCIKGGGACLYQEKLVAMRAKQFVCVADYRKLQKRLVTKWPTIPIEVEPKAARQVMKRLRMLGSISTTGAGPMIREGHMAKAGPVKTDQDFFIVDAPFPHPLLIAEDLTPDRRGDGEDGYWEVEQLARGIKDINGVLAVGLFCGPTGPEAMAAGVIGGQRPIACYFGMADGTVSVQKARHKRNSVIAKYPPLIPVHSSELQGAVASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9K4</accession>
    <name>A0A1C1C9K4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_06115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9K4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06115"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07834"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT45176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34195" checksum="E877BCD4F0C0B646" modified="2016-11-02" version="1">MAFNVFLTVRTKRNATELRKIDFVAVLLAFILPFIQAFTYLFWRPNGKTVYGPATLWCWIAKESAIIRLVAFFVPIWCFVSIAICFLALSGKQILRVRKSVKSAKAKSALHREEPALGPDGFPLPRERRFSSFARAFVGPTVSLESGGSVATATNGEQSSQLLSPQFKGLEPLSPLAPIQSRELLDLERQLQGGPYAQESLYQTSTSSSPFGTWHPTSPAGTLGRSPSDQPILPNSEQVSSRRSSSRFDRIHWKYAKFALLCTLVLFVTWVRHVYPRSAFALIPMLPKISVLEPEDASRHELSCEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9L3</accession>
    <name>A0A1C1C9L3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfite oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SOX</name>
        <name evidence="7" type="ORF">CLCR_05665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9L3"/>
    <dbReference type="STRING" id="86049.A0A1C1C9L3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05665"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07814"/>
    <dbReference type="eggNOG" id="KOG0535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02110">
        <property type="entry name" value="SO_family_Moco_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF6">
        <property type="entry name" value="SULFITE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="5">
        <location>
            <begin position="205"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="412"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT45151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="587" mass="67642" checksum="8379AA33DDEBCFC5" modified="2016-11-02" version="1">MHTDVRMRELRSHYQVVLCHHRVLRGEPQDEWKLEQGLAAAELPIRDQTLPEGQFVEDVPPDPELEKELAEVKEFVEKDEIDRDVVFAEERPGWRGYIEWEQYPEKKAIAHKIMMGQTFPPPPEFQLGAIPDTNPVLEGVRWKLWHKAIGGPLASVPEESWLRVIQEKHPDMLHLLQFPYNGEPPKRLVTAKPITPTSLHFIRNHGGIPDIDADAWELTLDGLVKHPRKFTLKDLQNEELFPRMEKLVTIQCSGTRRVEQIQMYAGEGDEMINAPWAEGAIGTSRYVGVSLKKVIKQCGGMAEGGKHLEFHGADTYFKQNELMNYLVSVPWSKVKANEVMLAWEMNGEPLPKIHGYPVRLVVMGYIGARSVKWVYRIRGLAQPTRAPVQSKEYLYFNQQVGKHNQLPVNGIQIQEMPVSSAIMSPWTKQVVVHDGKIQCQGWAYSGGGRWPERVELSADGGFSWYEVPPEKLSAKHKFAWRTWEYELPCDVEGWIEIVVRCWDNSLNTQPLDVRNSWNWGLHVTSSCHRVKIYSVNKTRERTRQRIADFATRGESLVPITRPTEFPTMAPEEYDRYWATHEPRDVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9M9</accession>
    <name>A0A1C1C9M9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">she9</name>
        <name evidence="15" type="ORF">CLCR_05780</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SHE9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9M9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05780"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07887"/>
    <dbReference type="eggNOG" id="ENOG502QQ1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5595506at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT45234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="527" mass="58559" checksum="2A10E3666B8E7A8A" modified="2016-11-02" version="1">MHQAPLRLSQTLWSAFRAAKPVHKPLRQPRQYSPLARSSRQAWNCQRPSIAVQARFYSDKKSEVDRNVEDAKNRIEDSLDSRADAAAQTEQTLKNPADETIVHTIPEASSIVHTSRHEDPKPLKPEAHSQPEAPPADEPLPDSIAARYANLQKRFGHFMDNFQTHIFTASRRLNDLTGYSGIEALKNDIEHQESVVQQCRQEVKASREKYSEAIAQRSSTQREVNDLLHRKHTWTSGDLERFTSLYRSDHANEQAEAAAQKNVSDAEQRYEEASTKLAKAILARYHEEQIWSDKIRQMSTWGTWGLMGINVLLFVIFQVVLEPWRRRRLVKGFEEKVELAIKESEEARAATAMQPIQSAALPPDDDVPVPVPVAAKVDAVADNIAGQIVDAITGTAPDDAPTAATIPTEPEPTPLPSQENIEAAAESLTADELAGEEDNLLPGSPDIPFPATAQSTIPASGPDENISSLRWTSPSSALAKYEEYLRSLFSEDHKILVSQWDLTKVAMEGVAGGVAVMGLLFVLLRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9N0</accession>
    <name>A0A1C1C9N0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9N0"/>
    <dbReference type="STRING" id="86049.A0A1C1C9N0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06199"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07888"/>
    <dbReference type="eggNOG" id="ENOG502QRU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="276" mass="31615" checksum="8E55A5645B40B121" modified="2016-11-02" version="1">MPFPQTLEANPRVIFFTDFDGTITLQDTNDFITDNYGMGLEQRRKLFHAVIDETDTFRNTFQQMLDSWNMPFPKVLEILKENITLDPGFKDFMVWAREKKVPVIVLSSGMVPVLETLLNHLLGEDLMKDIEIVANETQIRPPGNSLDKPDGWTILFHDESGFGHDKSLTIRPYAEAIAKMPHDQRPTLLYAGDGVSDLSAARETDLLFAREGKDLVVYCEREGIPFTLFNSWHDILEETQDIYEGRNTVRKLAEEGLKRHRTNSMEANGHVKPTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAD7</accession>
    <name>A0A1C1CAD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PDAT9</name>
        <name evidence="10" type="ORF">CLCR_01519</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAD7"/>
    <dbReference type="STRING" id="86049.A0A1C1CAD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01519"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03395"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT45484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="509" mass="57766" checksum="9D3ED52ED97A64D4" modified="2016-11-02" version="1">MAPSIHLGHILPLAIVLLVAIPVAVLLRNRYRRGLCDIPGPFLASILPFDRMLSTYSGHQFQRHLDYHAKYGKLVRVGPNHVSLGDSEQISHVYSITSKFDKSNFYTLFHAKSPVGPIPTVFSIVDPVGHKNLKRPVGAAFALSSLLDFEPLADDCTRILERKLDALQGQDIDFGTWLHWYAFDVISSITFSNRLGFMENEEDVNGIIAAIEGRLFYNSIIGQVPWMHQWLLGNNFVSRLADKIPSIKRLNSAAYIVQFAARQLQLRQNVKAEHGRSDMLDKFKRTRDGEEVMSEKELLGHASSNVFAGSDTTAISLRALFYHLCKNPQAYQKCVDEILDFDARGELSEYVTYYEAQRMPYFQTCMREALRMHPAVGQLLERIVPEGGATIDGVHLPAGTIVGMNPWVAARDTAVYGHDADIFRPERWIEADERTLKLMDRNWLAFGAGARTCLGKNISLMEMSKLVPQLLRRYHVKLADPNAEWELFDYWFVKQEGLRCILSRRGKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAS0</accession>
    <name>A0A1C1CAS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_01509</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAS0"/>
    <dbReference type="STRING" id="86049.A0A1C1CAS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01509"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03523"/>
    <dbReference type="eggNOG" id="KOG2547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT45614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="529" mass="59272" checksum="927D6E15D6B2010F" modified="2016-11-02" version="1">MFTDIVAAVCIAWFLYYRHTPRRAAVLSFKSPGDIPNVTVIRPCKGLEPYLYECLASTFHQDYPRDKIAVYFCVSSRSDPAYDTLEAVVRDHHGYNARVFVEEDDDGLANGDKKESQYRQLLGPNPKIRNMSKAYRESGQNHLIWIIDCNVWVGRGVCARMVDRLCGFTRHGETSATPYKLVHHLPISVDVDTYSVINGRVDRQLTAPSSYDTGISATSAPGSTPATLAQYGGGRLEEVFLSSSHAKMYVAINTVAVAPCIVGKSTMFRRSHLDHLTLQAALKDRKYKEAAPLEARTGIDFFSHNICEDHLIGDLLWKSRLPVTPDLPGNMRNHGLVFGDLAVQPISSMSVTNYISRRVRWLRVRKFTVPVATLVEPGTESFLCSAMGSYGLTTSETTRNWAGTTWTAFWAWWGLSILCWMAVDWTVFLLLHSGRTVEANGGDGKVPGFARPLSTGSKARRKFTTWMVAWLGREALALPVWSWAIWGGTTVAWRDGKYWVGLDMKVHEIKDRQRGMKGTNGHANKQRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB98</accession>
    <name>A0A1C1CB98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_01439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB98"/>
    <dbReference type="STRING" id="86049.A0A1C1CB98"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01439"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03677"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000421">
        <property type="entry name" value="Serine/threonine-protein kinase PAK 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF27">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="38"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="373"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="638"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="646"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="687"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT45785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="764" mass="84721" checksum="350F2142E6010190" modified="2016-11-02" version="1">MAMISPYSETPHGVRTAPQSYFEIQEDSSNGDTLADRYQMLEELGSGSFGIVYKAIEKATGEIVAIKHVRLVDQMAVRENEGLIRGQVDLESSEEDLSDILSELSVLSSCSSPHVTKYRLAFLRRQTLWIVMEYLGGGSCADLLKPPPHRLSESHIAIICRELLLGLAYLHSEGKLHRDIKAANVLLGMDGRVKLADFGVAAQLVGLKSVRNTFVGTPFWMAPEVIQQEGHDAKADVWSLGITAMELAHGEPPHANVHPMKVLFLIPKQPAPRLEGTQWSKDFKDFVACCLTKDVDRRKSAKELLGHRFIRAAGKIEGLQELILRKQDWEASKGGDRNLKYYAETLKNLSQCDNDDGWVFETIKAVPTMNLRDAQTQKKRKVSRTTVDVMAESKESATQMMRQLSLERRPEPDQSPTKLTMRKISESKQQQYQPDRRDSVDSLSGKRTGRKRLSNAQPRHPLGVNMSFGNSPSTVRQFRRVSTNNSVTPDENEDPNSSVIRTPSKAKPGIGVLVDLETSLLSKPDKESRFSTATTLAMESKEANLGKKLYSHAIGLSCQDILNDTADEVKREAVARLAEAFSDLESVDPDGMYHIMSSIISKMKEDDTLKAMLPQPAPATTSSPQKVGHAQPELVVSPEKPAIANESRQVTPSTPTKSGQAAKLVLAQNNPHLKSHRRRQSAQAVISSRSPSRVNSTSVSQVNSPLRNSSAEERKEGRKVTGVDETEEKEMIKGLVGGLEHTRQLGESLFDRWCEGLRVRWPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBF1</accession>
    <name>A0A1C1CBF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_01377</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBF1"/>
    <dbReference type="STRING" id="86049.A0A1C1CBF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01377"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03697"/>
    <dbReference type="eggNOG" id="KOG0059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001345">
        <property type="entry name" value="Related to ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="840"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1014"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1055"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1090"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1118"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1156"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1203"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="477"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1263"/>
            <end position="1490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT45806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1619" mass="177152" checksum="9A3989A0F2217CEA" modified="2016-11-02" version="1">MALFVRQVLTLTLKNLLVAFIRRWFSTTLRAFFLPVVFVGFLSYARFLFIPPSVYGIGEATPIRGLSEALSLVSGGRDKLVFVNNGFSDGSIQSVIDRVANNTGSFGSQVEILSQEEELLTVCRNSIRGTSTCIAGAVFFSSPSEGEAGRWNYTIRADGGLQTKIMTDSSENDAEIYLLPLQHAIDRAISEVEASSDSGRVLPQTAEEYPYTSMTKEERLRQIRTRYMGGIIDILAVAFFIEIVGVTYQLTGVIASERENGMAQLLDCMMPNRKRWQPQMARIIANHLAFDVLYGPGWVIMAIILSVGVFSKTSAAIVIIFNILSGLSMSSLSIFGGAFFKKAQLSGITSVIASLLLAIIAQVASKAGTASVAILSLLFPPMNYVYFTIFMARWERQDLATNLVKRAPENTSALPGIAFWIFSIIQIVVFPVLGAYVERTLYGTASSNRTTTYSDAHTAVSLHGFTKEYPPSRLAPLRAIFTRKRLTTVLAVDDLSLNATTGQIMVLLGANGSGKSTTLDSIAGLTSITSGDITVNYPEPDTGLGFCPQKNVLWDDLTVEEHVRIFNRVKSLRPSSKDENLQLLASCDIDRKASARSKTLSGGQRRKLQLAMMFTGGSRVCCVDEVSSGLDPLSRRKIWDILLAERGSRSIILTTHFLDEAELLADYIAILSKGTLKASGTSVELKHKLGSGYRVHVYKTHGSQHLPTFKDTSYVQRDDQTIYSLTDSAKAADFLGRIESEGFAEYQVNGPTIEDVFLKVAEEVKSDSDPTEKTATGHVLQEVGSHGRGDFDGDEVAKVVVENNSPAQPPQLLDGRRISMPRQALVLFSKRWVVLRRNTLPYLAALLIPIIASGLVTLFLKNFQKAGCSPASSALVSDIISLSTQIDYQLVAGPRNRLGADAIQLLASTLAGSTGVAGVAANTTKLLESVNLVDSLAEFDNYINNHYANVTPGGFYLGDESSPPTFAWRGNGDIAFPVIIQNAMDTLLSNVSISNQYQAFDVPWGADVGKALQLITYFGLAMAVYPSFFALYPTIERLRNVRGLHYSNGVRSAPLWLAYTTFDFTIVLLASAVAIIIFRAVSDVWYHIEYLFVVFFLYGLSSTLLSYVISLFSRSQLAAFAFAAGGQAVMFLLYFIAYMSVLTYSPIDKIDTNVNICHFTIAAISPVANLTRALFVTLNVFSITCRGRQFASYAGSMTTFGGPILYLILQTFFLFLLLLWWDSGPLFRHLRGKKQQEQVEENDTVEAEVSNELTRVNSSQDGLRVLNLTITFGKTLAVNNVTFGVPRSEVFALLGPNGAGKSTTISLIRGDIQPSRRGGDILVDGISVISHRAQARSRLGVCPQFDAMDTMTVAEHLHFYAKVRGVSDPRHNVEAVMRAVGLKQYADRMAAKLSGGNKRKLSLGIALMGNPSVLLLDEPSSGMDAASKRVMWKTLESVVPGRSLVLTTHSMEEADALATRAGIMAGRMLALGTTDYLRRKHGDAYYVHVVHRQAPHASEEDMQRIRDWVLDNFPDASIESKVYAGQIRFSVPTKGFLPSKDGGEITGGSGISSLFTALEKNKSGLQIEYYSVSRATLDQVFLNIVTKHNVEEEGGETVTAPRTSLLKELSRVSSRFANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBG5</accession>
    <name>A0A1C1CBG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative RING finger protein P8B7.23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_01459</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBG5"/>
    <dbReference type="STRING" id="86049.A0A1C1CBG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01459"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03709"/>
    <dbReference type="eggNOG" id="KOG2164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000512">
        <property type="entry name" value="RING finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="183"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="670"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="578"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT45818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="695" mass="77369" checksum="3568F15B968E5F8D" modified="2016-11-02" version="1">MSSSATSLQPASKLPPASSASNYSQAAPDNSFSKRSLSSGSAGPSALTRQTSQARGNQPLRKQHKQQKKPRLIDEDETHAMRSVNSRKGQTSITHLMNFTLPPRPQHHLQHYNHRHNQTRHRTWGLGSGYHAVDKARYVHANYRFIVRPDREYHAQTVDADIYVSWDAVLQVLASAETQDTSCPICLSTPVAPRMAKCGHIYCLSCLIRYMHSTDESNPVPEKRARWKKCAICEDSIYMSDTRPVRWIYGNDVSLLREGGDILLKLLKREPGSTLALPRDTAESYGRSDDIPWFHVAGMMDYARFMKGGEDYMVAQYDQEIADLDTQGKEDELMFGDDNTWTRKAVLAIEDLKQKLSGLGNPPAAGPTTSACTKQAEVPESWDAADQQQDSILTTALQEMSLSPIAIPAKSAPIPPRPGHGPPRPLAHSFYFYHALPNFFLSPLDIRILKAAFGDFSAFPSTILPRMEHISTGHVIDDDLRKRAKYMAHLPYGFEVSFLECDWTDVISPAILEQFKEEISRRRKRNSEKEAREERDRIRAEKEEEDKRWAAARRPRRPSVGTKSFTDTDFQPLVDPSTHASSSPGLESNPATTPPWGNNRAQSAFATLATPGTSPDAPRTVWGTTAVAPTTPPVMAAPAPTVQVDDGWLQDWEKDLLDEGEAVAMVEASLSGGGRQKKGKKKKITLMSTGNRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC38</accession>
    <name>A0A1C1CC38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_00392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC38"/>
    <dbReference type="STRING" id="86049.A0A1C1CC38"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00392"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09990"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="138"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="659" mass="71592" checksum="5D9AD6EC9F4FDB49" modified="2016-11-02" version="1">MDLELGHDLPGYPGPHGRAFPDLEARVHLGSLSPFNHLHYVTELMLLRPEPVARYIWRLLPRQCTLAAVFSQQEANGPVRCGQDAIFLFVVVSGAFAAPFACPCTELPAAGGFRLRNPQGHQFQRKCPWPRAKKYFFGANNAKQRTGQTYNFSNIRYGQAPVGDLRFAAPLAPAGRNEVIQNGSVGRICPQAGPAWSPVAAEFLQYLVAGNASAFNLTEVEQQLQAASQNMSAARIDPRMTEDCLFLDVIVPEKVFDGARSRIKRRQSNGAPVVVWIYGGGYTGGSKGGSGNPSGLIASSQAGGGNGIIFVALNYRLGAFGWLAGPSLQAAGGVSNAGLYDQRLALQWVRDHIHLFGGDPKRVTVMGESAGAYGGQRGVPFQQAISQSPGYLPISSYYVQENTTQAFLSMLNVSTIEEARNLSSTSLMVANAQQVAASRYGGYTYGPVVDGIFVPALPSVLLNAGQFAKNVKVMVSHMLSEGPYFTPPNVQTDDELEAFIQLNTPGFPTELVNYVVKTLYPARYDGSQPYTSPIERTILFITETSFVCNNYFLNKAYGNQTYAYQFAVPPGFHGFDIPYIFYNGQPTNQTAGMIAPVGVALQTYLTNFIMTGNPNGRGMPPFPMQGINASMNSIGTTIQRVKDDTSNERCAWWQKALFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCW3</accession>
    <name>A0A1C1CCW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">abd1</name>
        <name evidence="16" type="ORF">CLCR_01111</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for methylating the 5'-cap structure of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCW3"/>
    <dbReference type="STRING" id="86049.A0A1C1CCW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01111"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09164"/>
    <dbReference type="eggNOG" id="KOG1975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000231">
        <property type="entry name" value="mRNA cap guanine-N7 methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="15">
        <location>
            <begin position="313"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT46365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="661" mass="74962" checksum="F5E264BA32759DB1" modified="2016-11-02" version="1">MSDSTRNPAPPKRRRSSLAYDPARDTFKELPDALAEDAIAEDPEEEHKAEAAVTASPTTAKGTKEQPRKRGRSESVDGEVKDSFPEEKHTRSKRSPPDSGQIMSEQPRKRKRSQSLDGEANDSGTRKDELSEESRAPTSPSRGTSKPATNADQGEKTKPRTPADLPRIPRKTREDEPSTSRPASDAYSRRPEAGERRRQDRRDAPSHRRSRSPPSRRSPAETYRRRSPPRERRRSPSPIRVSPPPEVIRPGGARGRGRNVLAEQQRLAAEREQKQAALLAQTNRGVQEVSNQWYNQRPEWVKEKGRDWRKNESQIKGLRSFNNWIKSCLIHKFSPEEKEEEEEAGWGEEAKEPAEQKPLLVLDIGCGKGGDLGKWQLAPQKVGLYVGLDPAEMSIKQARDRYDQMRRGRRPIFDGRFFAQDCFGAWIGDVGIVREVGIDPNAGNGQPSRWGGGGFDIVACMFAMHYSFESEEKVRIMLRNVAGSLKKGGRFIGVVPNSDVCTENIQKWFKNKTANKLEANGGVEGASEEKEDGEADEEGPSWGNSIYKVRFPIDPVRPLQPDGSFRPPFSWKYTYWMAEAVDVPEFVVPWEAFRAIAEQYNLEQRYRKPFLDIWNQEQGNREMMQLAVRMGVVRYEGGDIQLTQEEREAVAFYHAFCFVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD97</accession>
    <name>A0A1C1CD97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_02039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD97"/>
    <dbReference type="STRING" id="86049.A0A1C1CD97"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02039"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01201"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="220"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35672" checksum="C47F0452DCD976C1" modified="2016-11-02" version="1">MGLMAISDFADDDLAATIPLFLGPWTGMEHIIMASYDIEALANTIQRTKATAAQMTPNGALTIATTDLAERYDVSSIRHMICGAFPLKQDDYDRFLRKGNWKTVTLYGMTEAAPYVSWQKIGEAMPLGKSGTILPDILCSLRLENGDDAPEGGPGELWLKGPNMAAGYVDNPEANRAAYDEAGWYNTGDVCTISPEGHLQVVGRTKELIKYNGFQVSPTELEAHLISHPAILDAAVGGTWDSAKMTELPTAYVVLKAHLKDRGQKVQALQDIERTISSQVSGYKKLRGGVFEVTALPRTPTLKFVRKQLGIHKTGLSSLDGGERSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDM4</accession>
    <name>A0A1C1CDM4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02141"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01273"/>
    <dbReference type="eggNOG" id="ENOG502T0ZY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3649348at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="133" mass="13861" checksum="510F6987D000CF55" modified="2016-11-02" version="1">MAPIAAILCGREPKMAQAMIKNLAPKIEAVSEIPALLRGETTAPSSGLGANAEGSARSDVSLIIIGGGYPKDDVQAIKEAADAVKPLPLFCADVSKTAGSGPPPPDMIKKRIIDSIEKEEKGEGEWAPGVYMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDS0</accession>
    <name>A0A1C1CDS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_01844</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01844"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01326"/>
    <dbReference type="eggNOG" id="KOG4629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF14">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="715"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT46597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="775" mass="86589" checksum="D7036E61123CF5D8" modified="2016-11-02" version="1">MAGKGPIVTVQDDISDYQEKQSTHYPNGSVELSRKSSSPINRPRAARQLSDSDNDDEGLTQLGIKWQRIRRNVLVRYIIYIVPVAILLAIPIVLCATVYKDKKIISKFKTESQTPIFSSNITSVEPTSTNGTTTYNNTASTVYQQTTTTTNEDGIHLLGLFIWIEVVWVLLWIAKLLAQAVPIIFQTVGGAIHTGIRKYWLVLKAVEIPISLFFWAILSIASWSLIYVFDKPFHAKHAGNIKWLHTLRNVLKATVGVTALYLVERMLIQMVSVSYHGKQFYDNIKELKTLSRAIETMYDVSRQRFCDNHQRFLEDDLDIHDTKGYRKDRYGRLRSKDQSTAEFMSNLSSTADKLTAVVGYLVSDIAGKQVLMPTASGPIVEAALERPVSAEALARRIWNSFTNFGETRLDQAAITTMLGPGREAQAVYIHSKVDADENGDLTLEEMVELVKKVASDRQTIWEGANNVKDAIKVLDRVLGVFVLIFIFLIYAAFFSDYLANHYTQIWSAFTGCSFLFASTAGELFAACITVFIKHPYDVGDRINVNDTEMDVVKISLLYSVFREVNSKQMVQIPNSVINGVWIKNLTRSKELREQVTLNVNVGTSFDDIETLRGEMHNFLAENKRDFMPELEIQLFSIADLSKLELRIEFQHKAKFASDHVRAQHRSKFICALLTAVRKVPIDGPGGSGPGSGSMESPTYSVTITDDIAKAARAKFDEEKDKKRMHPKNQPAESEIGVAVGGPVGSTGLQVMPSTARSRVGGGLGSDDFTDISSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDV5</accession>
    <name>A0A1C1CDV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_02009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDV5"/>
    <dbReference type="STRING" id="86049.A0A1C1CDV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02009"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01373"/>
    <dbReference type="OrthoDB" id="4158815at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT46648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="36240" checksum="50607ADF2480D88C" modified="2016-11-02" version="1">MANEFNIDPNVWYQISNDLFDPKVNSLRVGDSHTAIYMFATNLTSPQQRWQIFPVSGGGGGWNFRAQITGSGAYMSQCVHLTSTTAPTDANPDDTDVCMALGAAADIQRQWILSSNGDGTFDIKLSNSNPLYSDYHLFVNESNTVAFSNDTTEEGVKWGFQSITPIDDPAFSTGIVPVASTSSTTRSATSTSTSTSTDTNTSVPTSPGSQTPTQTQISSPTTSSAPTQQSSGLSSGAAAGVGVAVAIAVLALAAILFWFFRRRRRHSREQIQRQVQELATPYSGHDGASFPHETKNRQIYHAEPAELHHQSLAELDHTPERKPPVAELGADPRASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE09</accession>
    <name>A0A1C1CE09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_02103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE09"/>
    <dbReference type="STRING" id="86049.A0A1C1CE09"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02103"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01422"/>
    <dbReference type="eggNOG" id="KOG3243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.960:FF:000005">
        <property type="entry name" value="6,7-dimethyl-8-ribityllumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT46701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="228" mass="23430" checksum="47C7AEF4421180B7" modified="2016-11-02" version="1">MASLKGPGAAQKHDGSGLRIAIVHARWNTTMIDALVSGAKKAMLAQGVKEENIVVESVPGSYELPLAVRGIYQASQIQSTASTVAGGVGNLASGIGDLLGGSNSTTDLHGSLQPGPPEPEKKEAKGLKHTFDAIIAIGVLIKGETMHFEYIADAVSHGLMRVQLDTGAPVIFGLLTVLNEGQGLARAGLEGGTGKEAKGHNHGEDWGNAAVELGVKRKGWGEGKIAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEQ2</accession>
    <name>A0A1C1CEQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02616"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02427"/>
    <dbReference type="OrthoDB" id="5418774at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="192" mass="18909" checksum="13E77CCD705910D9" modified="2016-11-02" version="1">MVKVAENRVIDLDLLPGDKRGDKLAEQTKAAIAGKVPQGEAQGVSSNTQNAVTALGGTVGGGVKGVVDAVGNTVGALGEGVVGTVQGVGDGLGSTVQFAGGAVGAGAGQIGSMFSGSQKQGGEDPKELQKQRLEEATDKTKEISGDLEDSVQEHSKSAIGSTQESTEGGKEATGGVAENTKEKVAGVASSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF10</accession>
    <name>A0A1C1CF10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RPT5</name>
        <name evidence="15" type="ORF">CLCR_02407</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF10"/>
    <dbReference type="STRING" id="86049.A0A1C1CF10"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02407"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02363"/>
    <dbReference type="eggNOG" id="KOG0652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="245"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="63"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT47058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="466" mass="52177" checksum="4DE058EC3337990C" modified="2016-11-02" version="1">MSTLEDIDDLERDEKEQKKDGDDKDKKPSPNGDAKDAEMKDAGPDKKDEEEQYIDDEILQSSTRDIINRRRLLENEMKILKSEFQRLKHEETTMKDKIKDNLDKIENNRQLPYLVGNVVELLDLDVEAEAAEEGANIDLDATRVGKSAVIKTSTRQTIFLPLIGLVDHNKLKPADLIGVNKDSYLVLDTLPAEYDSRVKAMEVDEKPTEKYTDVGGLDKQIEELVEAVVWPMKEAERFKKLGIKAPKGALMYGPPGTGKTLLARACAAQTNATFLKLAGPQLVQMFIGDGAKLVRDCFALAKEKAPSIIFIDELDAVGTKRFDSEKSGDREVQRTMLELLNQLDGFASDERIKVLAATNRVDVLDPALLRSGRLDRKIEFPLPNEESRAQILRIHSRKMTIDEANINFDELARSTDEFGGAQLKAVCVEAGMIALRKGQSKVNHESYVEAIAEVQAKKKDTVNFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF25</accession>
    <name>A0A1C1CF25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,4-dichlorophenol 6-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tfdB</name>
        <name evidence="5" type="ORF">CLCR_02309</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF25"/>
    <dbReference type="STRING" id="86049.A0A1C1CF25"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02309"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02353"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF8">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="23"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT47066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="614" mass="69209" checksum="D39311BF78C165EF" modified="2016-11-02" version="1">MSADTTDIPFTSPDGDSQCRVIDTDALVVGTGPAGASLACFLGSQGIQGIVIGNASTTADTPRAHITNMAAMVAMECLRDIDLERDCNQVASHNESMQHVRWAYSFAGEEFGRMYSWGNDPEQKGDYEKASPCVPADLPQTLLEPILVRYATLHGFKCRFDTEYVSSTEDKDSGRILVSLKDKLNGVGFQVRCRYLFGADGARSRVAKQIDLPLIQKPDKGIAYNVLVRVDMAHLMDARMGNLHWIMQPDKEHPDWAWICVVRMVKPWYEWIFVVFPDRKAAWVDHKPTNEQWLARIKEFIGDDSIPAEIIGVSKWRINDTVAEQYSKGNVFCLGDAVHRHPPMNGLGSNTCIQDAFNLGWKVAYVLKGLAGPELLESYSAERQPVGKGVVARANQGFSDYGPLWDNLGILEDDVEKRRQIWHELSEHSPVGRKRRQTFQKTLHATKSEIQGLGIEMNQRYTAAQAAVYRDDEESRSPPDFTRDAIRYYEPSTYPGCRVPHVWLTTLVPGKKISTIDLSGKGRFTLFTGIGGREAWQSAAARVKQELKTPIEVFSIGHRQDHEDIYMDWARLREVDEDGVVLVRPDRFVAWRSQSVPEDCDDKLVKVMRRILCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF68</accession>
    <name>A0A1C1CF68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase,short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF68"/>
    <dbReference type="STRING" id="86049.A0A1C1CF68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02575"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02260"/>
    <dbReference type="eggNOG" id="KOG1210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF7">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE (AFU_ORTHOLOGUE AFUA_2G00830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="300" mass="32204" checksum="7F399DB1479FB705" modified="2016-11-02" version="1">MASVFRPGALALISGGASGVGFAFAQHCRRQGMHVALLDINRATLTAASSALQAMDNKLLTLTYEIDVSDLDAWAAVRADVEGKFQTIDFLMLNAGMAIRTTTPWKDASYFHKTLATNYFGVVHGLVTFLPLVTKSSGPAAVVMTGSKQGITNPPGNPAYNASKSAVKTTAEQLAHDLRTSGSTIYAPHVSAHLLVPGWTFTGLSGNVGPVPDEAALKNKPRGAWLPSQVAEYGVQKIERGQFYIICPDADVDEALDNARMTWAVGDITEGRSALSRWDEKVKDEAAGWIQKEAERRRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFB5</accession>
    <name>A0A1C1CFB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Multisite-specific tRNA:(Cytosine-C(5))-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NCL1</name>
        <name evidence="13" type="ORF">CLCR_02259</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFB5"/>
    <dbReference type="STRING" id="86049.A0A1C1CFB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02259"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02219"/>
    <dbReference type="eggNOG" id="KOG2198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002127">
        <property type="term" value="P:tRNA wobble base cytosine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="60"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="492"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="791"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="863"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="793"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="178"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT47213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="886" mass="98811" checksum="59A7AF3BD1D6EB4B" modified="2016-11-02" version="1">MGKRGGGRKGGGRGGRGGPARPRDNRDFRFSKQDIPRQNERFEKYYNQLGILPDDEKDAFWEAMRRDLPNSFRFTGSREHALAVQQRLKDYYIPEITSITYEGQYVDAPRPVEWYPEQLAWFMTTPKNVIRRFKPFASFQKFLVAETDVGNITRQEVVSMIPPLVMDLRPGMSVLDLCAAPGSKSAQLIEMIHAGEEERCRRVASNPDLDSPSGEDFADDGRSTGLLIANDVDYRRAHMLVHQMKRLSSPNIIVTNHDATVYPSIKIASPPTTEGKPVPNRYLKFDRILADVPCSGDGTVRKNMEIWKNWSPSNGLGLHATQVRILVRALQMLKVGGRVVYSTCSMNPVEDEAVLAEAINRCGGAQWVQILETKDMLPGLKRSPGLQEWSVMDKAGRIWKDYASVLQQREEQGGDDALNRLSEGMFPPKDELPLDRAMRVYPHQQDTGAFFIAILEKKSEIKAKPEEKHSVAPKVEIPGAPTVELEANSGAAVESGNGIANGDGTANNTTRVDSETLTKRKREDDSDLEGITSPLKRVKSEENLANTPSITDSLPQQSTKATQPPSNPNKKNRNQPFEEPFKYLSSTLPEIRRIRDFYNLSPRFPLTRFMVRNPDGTATKNIYYTSELSKEILQENEGKGLKFVHAGVKMFVKQDAPSPEVCPWRIQTDGLRLLETWVGPERIVRLRKKETLRKLLIEMFPKFNGEEGEQLGEVGEQVRKLSMGCCVLIVEPTETDENAADGEGLKERMVFPLWKSIQSLNLMLPKEDRKAMLLRLFNEETPLVNMSKGWTDAQKEKGKMGNGKDEDGASGNKATVTNADAAGASLIDILEESVDARLRRNSSSPEVEPVDDAGPVVEVDADDLMADVGSDGDDNQAGGVALPDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFE6</accession>
    <name>A0A1C1CFE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_02365</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFE6"/>
    <dbReference type="STRING" id="86049.A0A1C1CFE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02365"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02236"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT47198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="558" mass="63570" checksum="BC5361F36A3BC8DC" modified="2016-11-02" version="1">MYFVPGLFILVALLSYKIAAVVIRRQRNARTAARLGCVPPPTAPRKGFLGIGTLRESIRATREDRGPIWMHENLNAIGKTVHTVRAAIFDYELIITRDTQNVKAMFAAQSQDFDIGLHREKCFKSLLGPGVMTNRQEKWKHSRRLIQSQFARDNVADLDLFQRHLNALLRRMPVSEDGWTAKVDLSPLFYSFTLDTSTEFLFGQSVHTLSPEERPGMLSWDHNAPDLRAFGYHLDEAKHIIDRRGALAKYGWLLRDNSFPDHCKAVQDCVDYFIQKRLDGSWDERKVDEKTNGRPKFILLDELISKTKDHYELRCELLNVLHAARDTTASLLGWSFYFLARHGDVFARLRKEVLDTLSADPSAQITFAQLWSCKYMQWFLNEIIRTVGVVPMNERVAVRDTTLPCGGGPDGQSPVFVPKGTQVLIPTYSMQHREDIWGASVDEFKPERWQDRRFGWDFIPFGGGARQCLGQQFARTEAMYTISRMLQVFDKIENMEGPGPIKMHQTIENRSGTGTQVRLHLASSSFKSHCQRGECEGGLSLSEPYDLGLGAERGEKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFN1</accession>
    <name>A0A1C1CFN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-formylbenzenesulfonate dehydrogenase TsaC1/TsaC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFN1"/>
    <dbReference type="STRING" id="86049.A0A1C1CFN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02284"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02151"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02152"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="61211" checksum="1FD0B2AC0D166D68" modified="2016-11-02" version="1">MASASRGRLLQLTKLQCSIFSTTFNPMQQRLGNKVLRQRLRGPALAAYYPRRSATVEDVLKEFKRFDLAGFNEEEDDRFENVAFAKLRGKGAPKKKRTAAGTIYLCVEVDRSTDHVYRKSGEQEKEVMRTRSGFELRPTSPQIPMSSFGRNLSPPFRFHIAGTQTQASRSPGSQALVACAKAVLAEVLFAHKPLPLPQFLSRIPSDSVSPIAPATESASAGVEQQVIAGLVRTLGTIADGLGGLHEVQTGTGRLANKVAIVTGKDSGPLRVRWEKRECQKMLQSYPEQHRNRGHMRKMWFFVATLPPGSNSCYGDSFANGLSSPCTGAASGFGLATVRKFIEEGAKVVAADLNEQGLQKAYTDAADTHVALVTANVTSSSDWQKMVDLAVTKFGGLDILVNNAGTSYKNKPTLEVTEDEYDRVFAVNVKSIYLSVSAAIPALKNRGGGAIINIASIGAMRPRPGLVWYNASKGAVANATKGLAAEFGKDQIRINALCPLLSGTGLFENFVGVPYNEENMKKFLFNVPLGRLTDPKDVANVAAFLASDEGKFVTGVNLEVDGGRAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFR0</accession>
    <name>A0A1C1CFR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cct3</name>
        <name evidence="12" type="ORF">CLCR_02343</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFR0"/>
    <dbReference type="STRING" id="86049.A0A1C1CFR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02343"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02073"/>
    <dbReference type="eggNOG" id="KOG0364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000037">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT47363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="560" mass="60480" checksum="068F3E005767E401" modified="2016-11-02" version="1">MQAPVVVMNTAQGERQVGRKAQISNITAAKTVADIIRSCLGPKAMLKMLLDPMGGIVLTNDGHAILREIEVAHPAAKSMIELSRTQDEEVGDGTTTVIILAGEILAQALPQLERNIHPVVIIQAFKKALADALAIVEEISIPVDTSSDKAMISLIESSIGTKTISRHSELYCALALKAVRTVSQDQSAVSNAPQTNGAKAPAPAPPKPVEIDIKRYARVEKIPGGEIEDSRVLDGVMLNKDITHASMRRRIENPRIVLLDCTLEYKKGESQTNVEITDEDSWNKILQIEEEQVKKMCDAILAVKPDLVITEKGVSDLAQHYLQKANVTALRRVRKTDNNRIARAVGATIVNRVDDLVESDVGTGCGLFEIEKIGDEYFTFLTKCKNPKACTILLRGPSKDILNEIERNLQDAMSVARNVMFHPRLSPGGGATEMAVSVRLAQKSKSVEGVMQWPYRAVAEAMEVIPRTLIQNAGASPIRILTQLRAKQAEGKSSFGVDGDTGAVVDMKDYGVWEPQAVKMQSIKTAVESACLLLRVDDICGAKSAKQVGGSGLAGGGGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG24</accession>
    <name>A0A1C1CG24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_03575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG24"/>
    <dbReference type="STRING" id="86049.A0A1C1CG24"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03575"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01898"/>
    <dbReference type="eggNOG" id="ENOG502RZ4H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2163387at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468:SF1">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468">
        <property type="entry name" value="YALI0A15257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="156"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="320"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT47485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="355" mass="39017" checksum="9F051BA00D54486B" modified="2016-11-02" version="1">MNSQQHPYAAAQVAEKVMRRVEIAKVARNLQDCLAFASFKAQNGWQDRTLSSIEPEFTEKLKRKRPFLEEDLAVDTSSDEEFVPTSSIANNRFSKPSNPTFKVPEPPFGARKRVRSNSTTGLDRQSSASTWKHDHGLPQSSPALNRTQSFHEHTLLHPESARMHNTTDDSPMFDAHSDDDDHDMPAFGHEPSSSILSSSPPRTPPPTKRLLNPNTKSAGADLLLYLANSPSRSPAAHFHRPSDHSKEPPSTPPSQHSHLPSSVMTTPGTNLGLFNGALQTPGQNFNLADFCNVTPSPAPAQWRTPNMTQTPSRFSKRGLNFDSLQPPSGSPTLQRKTPSSKGLALQLGDELVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG84</accession>
    <name>A0A1C1CG84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_03451</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG84"/>
    <dbReference type="STRING" id="86049.A0A1C1CG84"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03451"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01854"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05131"/>
    <dbReference type="eggNOG" id="ENOG502RJRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="535" mass="60195" checksum="9EEC36B72783E388" modified="2016-11-02" version="1">MADAQVLKRRIGSGKACTSCRRRKNRCDGNRPSCGSCQSRGIRCAYPSVSVDELSLEELKSLIDLKSQGNVDAVREGQAQVQPQQHRRSSTVTTEPEEGQAGLGALLRASAEILRRDNEGSPATNFDVPCFNDDTIDVSIQNNAADNQTSPATTPPESQDSPAFFGESSTFAFVSKVQSNSVPRQAPVSRNKRRRLSGSKSPRTHSLDSGLTPRDVDDSWTMPPRDLADSLVDSYFNHVHRLYPFVHEPTFRSQYERMWMHDGDHPETKATWFALLNLIFAHGYEFHNPIQGRSPSHSATQFLVKARNIVFAHIFKEGNLELVQALLLMCHYLQGTLELNECWSLSGLMIRTSISMGLHLNPSPSTTAVEREVRKRVWWGCFVIDRTLSMKFGRPPSIPTVSAADVELPLPVDDQYIMNDSIIPRQPASCPSLTSFFIQTIKLAHIIDSVLLKLYPSTGKPWNATISQVRNNHDRFPEIFGHSVLLDGELLSWWNGIPHHLRDEPNNPDGSDFQRQRNVMYIRWAYIRAIMKTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGF3</accession>
    <name>A0A1C1CGF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_03320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03320"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01796"/>
    <dbReference type="eggNOG" id="KOG2466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT47590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="607" mass="66212" checksum="2A31654C40931AFA" modified="2016-11-02" version="1">MASGEKDYYNEKNLAPAVVEPAQVGHVSNFRRRFPHFSLEVRQEESSFAVTKSASNADFDPIPPSKRTWNWGAYIAYWMADAWAVSNWEVASSMIAVGLSWKMAIGACVLGNSIMGLVITVNGRMGAILHTPFPVLSRMPFGYYFSYFVVLSRCVLAIVWLGVQTTTGGQCMTVLLTAIWPSFANIPNHIPADEGITTGGMIGFLLYFLLQLPFLCIPYTKVQYFFAFKSVIAPIIFFAIFGDTLRRAGGTISNSTVITEGNKIGGSTLAWAFFANLNGVLGNYATLGLNIADFSRYANKPSAQNVQAIVIPFIFTIVGLLGIFTAAAAQSAYGDIIWNPIEIIGLWMESGSHGGRAAAAFGAIGLIIVTLGINISANSISAANDLMSFCPKYINIRRGQLLAAVIGSWAFVPWKILASAAKFLAFLGGYTIFLGPMTSILMTEFVPPNPTQAPGITSMSTNSFVSCRSYFIVRRGNVSVPDMYNFHGIYRYSPKFATNWRAVVAFFIGCIPPLPGFVNNIVAAGNGKTSVSLGGQHLFSIGYVYSFVAAGVFYWIFNRFFPHTESMMDHPETGEEIIAANDAKNVAERRASLVERRPSAVTRFFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGJ1</accession>
    <name>A0A1C1CGJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03726"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="166" mass="18388" checksum="BF15EF926210818D" modified="2016-11-02" version="1">MVNNKHSSTEDIRLGNGSLQPSTPPKTSCDNPQSTLQIRHQPRQVLRSGFQTPAFLSSFEVATMCYAIKIVHFGCLGGDQHAEYAVVRCKPGLEYIMLMPIKETCKGTKSVEDWRMDPCRFCKKYMQSRRGSGPSSGRFRAMSLPTNAPTGAEENDVSTDTEGHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGP8</accession>
    <name>A0A1C1CGP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_03565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGP8"/>
    <dbReference type="STRING" id="86049.A0A1C1CGP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03565"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04662"/>
    <dbReference type="eggNOG" id="ENOG502RYJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000609">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF40">
        <property type="entry name" value="REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14497)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="7">
        <location>
            <begin position="191"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="321" mass="36056" checksum="C1C8822210C602C4" modified="2016-11-02" version="1">MAQDINVMLYGLGAIGSFYAFILERTKRVRLTVVARSNYEAVREDRKVWLVLLFIWSRADRQPTVVRTPAEAGETYDYVVCAHKAINQESTAKQLAPAVDENNTCIVIIQNGVGNEDAFRELFPKCTILSCVTWVGASQDSPGIVNHWKSENTEIGLFPNPSLDAASEQTRLNEFTSLLREGKTPFSVEDNVQIQRWSKVIWNCAWNSLTTLTMLDTHSWLKSSPDSTPMTRRLMQEVIDVARACDVPIKDGLIDELLEKILAMQPIGSSMQTDCKMGRPMEVEIILGTPVRKGRELHVATPILEVLYTLLSAINTRMKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH64</accession>
    <name>A0A1C1CH64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_03318</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH64"/>
    <dbReference type="STRING" id="86049.A0A1C1CH64"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03318"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04505"/>
    <dbReference type="eggNOG" id="ENOG502SJHM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="629"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="727" mass="81501" checksum="E9F8CB13A42B098E" modified="2016-11-02" version="1">MMPGMAEEEAHPQLLEPRRACQECNRKKTKCDMRRPVCGLCLRTGNSCTFPSKRKKPTQRKPHLKAQSRKISDSISRLVQVLEAASRGGESSHGQDGRREIPQTLLRDSLKGLLAEIKETDQQSADNRDQATDQQNQSAASDADDAEDESHEANEQEHQQVPPRSSTEPSTKLPTPTMTSASEGTITCSVAIDLLNLFFDKVQAWVPILHRPHFQAKYESQLLVDGDVMQGLPVDESLLFYSVFAMSARFSTHPRFAGVPPNKRGYEFAHRAREFYSQARSLRNPSLTYLQGCILLANYFYTSGPTHQGWILIGVCVRLAYDLGLSEVDDEDWSPPAPIGHVEKEEMRRAWWAVWELDTFASTVSRNPYSIDRKRMAVALPISDEAWFAGVDVPSAQLNMLPGQSWRSLQDCSNQDERAWFLVANHFMATVHDRLQQKQDISPDEKLTLENEICCFKLALPASLRLDAETLAFTPATFARCNWVIGTHLMLMAASFMVSGISTAEPDDRSVSSVGAGLSSPLRQRAIDLSRIISLWDSRYIAVAHPFFTCMMLPPYYVDGDILKTQPLIASSHDLGKLVLAHFSERWKLGSVVSELARMVERGGTLNAEERQLAKRYAVFFRMPRLSGNTPPDLNKRDRNGSIVSDRASYSGPPDVPQQQPPPLQEDYSASVNVSTHPDVTEYDASMFDPQNFPQLPQEFYDGSNEIDFGFSDFFGGYKGDLGYMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH76</accession>
    <name>A0A1C1CH76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-ornithine N(5)-oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_03381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH76"/>
    <dbReference type="STRING" id="86049.A0A1C1CH76"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03381"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04478"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="66423" checksum="EF15F9D98FDD6C5B" modified="2016-11-02" version="1">MESFDLVIVGAGWHGLAMAKTYHEVCPDHTMLVVDAAQSIGGTWAEERLYPGLKTNNIIGSYEFGDFPMTPERFAVQAGQHIPGAVVHEYLCRFAKEFDLTSRIRLRTKVESAEMQEGGDWLLRVCTIGVGSRQISTLLARRLVVATGLTSEPHLPDYKGRASFTGNLLHSRQLRDRADDIRQSKEVVVVGANKSAWDTCYTAAMAGAHVSMVIRPGGGGPSWVWPVKLPFGLSLQKMATTRFFTMFDPCIWGENSGGFGWARRVLHRTWLGRQFVKWFWKMLAIPVLSANGYSTHPELAKLKPWSSMFWMANSLGVHNYETNWFELVKQGKINIHIGDVTSLSGNEVFLSNGIVLVADTFVSCTGWKVAPPIEFLPEGITTELGIPGLRASEDTSLLKHAVEEISRAVPELQAGPVKTLPKGSGPITSTRDSKTPTPYRLYRFMVPPAPKFLELRNIAFIGAHLALNAITVAQAQALWITAFFEDGIPHLKHSKLDVNDIQYRTILQSEYCRLRHPPAGGGAGERCPDLVFDGLLYTDLLLRDVEVDNFRKRGTWQELFHRYLPKDYAGMTFELATHLQRAQRAQNAGGASAQEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHA1</accession>
    <name>A0A1C1CHA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Superkiller protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ski3</name>
        <name evidence="4" type="ORF">CLCR_03258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHA1"/>
    <dbReference type="STRING" id="86049.A0A1C1CHA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03258"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04463"/>
    <dbReference type="eggNOG" id="KOG1127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="440"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="638"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="711"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="968"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1398" mass="154875" checksum="7C1287D1FBCC8072" modified="2016-11-02" version="1">MASTKAALKAVKSSLDGGQFAKAAEQAEDLLKQDGQNHTACLFLGFAREKLGDLDGAEKALLRGAAVKPEDVQAYKGLVTLYEKQGSAKLDQYHDAAFKLAEIYAHSEDKAQCQNVIDKYELFAKKHGSRAQYRRALELILPTSSLYSILEGRVLQPSLTYLRILESAEAEEREWINTQIGERRTRLGAKIDQVTRQVKCEAISKFQIEEKYAALIDWTRDDDARHDLEQKLLQRTYDNLLVLPQDVKASQRDKILNMANGMVIIKHPFPLAWKIALEWVDAEDLQEWDVNIFREYISYFPDDGLSKVLRAFLDSNASPFPHPEFEEKEGEERPQRLSEADQLILMTEGLEDCPDSLLGQRIMAHVYLHLKEWQGTVDAARKAQKLHLDAQQRYAVNLDNSLDGVNLILANALITFQSPRYHPEAKDLFLAILDRKPKLTPALLGIGLIYEEDEDYAQAVKFFNQAAERDPANIRIKLELAWCRAHNGQLQQGLDELKAILSVLEAEKPQNQDYLMKSVTLYRIAYSHWQLHPSASARKDKSGAYQYLIASIKANPSYAPAYTLLGVYFKDYGKSKARARVALQKAFELSTSELDAAHRLARAFAESSEWDLVELVAQRVVNSGKARPAPGSKKKAHSWPYAALGVVQTNKQHYSQAIVSFQHALRISPDDYYSWVGLGESYHNAGRHIAATRAFSKAESIQHGLPAEETWFAKYMLANVQREMGSFDEAVTAYNDVLSLKPGEFGVLIALLQTISESAWAKVALGMFGEAANLASNAIEVAAQISKQRTDVFNLWKSVGDACSVLGHVKLYARTTNMSTVLKLLQTPPHGEVSNLSETDKVNMDSLASVGAESASDKADQYLLASILANKRAIHASTTDQHAQAVAWYNLGWAEHQAYISGGQFLNIGGKKPRRFLKAAMKCFKRTIELEAGNPEFWNALGVVTMTLSPKVSQHSFVRSLHLNDHSARTWTNLGVLYLVNNDHQLANEAFTRAQSEDPEYSDAWIGQGLLATLFGSLGEARGLFTHAFEIADSSALPAKRHYALSAFDHVSSHPSRSQEVSALLKPLFAMRQFHAQEPADTIATHLMALFAERVGDHDTSADALQEVCDAAEAEYEKTESNEYLVRFAQAKADLARAQLACGKYADVVSNAETAIDLSGEADDLGPAYADIRRKWRLSAHITAGLAHSHLRQIESSVEMFKVAMHEASREPDVVCMLAQVLWAKGGEAEKDAARTQLFGVIEDHPKHVHAAALLAVIGLMDNDKDVLEAVEEDLKGLRRDDEVSVLDKIRVSKVLAGLVGCRPRQAGADEIDQVAMAADALNGIMLAPGQPQGWLELAQAVGRDDATYAAEMAVLNAERQIPPGGDLTAEDLARAYEGTGEAENILKATMLAPWRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHD7</accession>
    <name>A0A1C1CHD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHD7"/>
    <dbReference type="STRING" id="86049.A0A1C1CHD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03938"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08102"/>
    <dbReference type="eggNOG" id="ENOG502RYII">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5359231at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="681" mass="76686" checksum="86FE1560DBBA4D6E" modified="2016-11-02" version="1">MLCYTAGGYLRILNFNAQRTTEKVFEGRVLVNHIAVTQLQTGLLDLDSLHGMQVLGYAHDITVLHCDFGSFGQYVFAIDVSDATPSSGSSTHGLHPRVRLCSRIRSNNKLFVRHTDKYLVVGSHSATGSHGHHEWLLQAFHLDTAEPVHAEPLQLQGFYGSEIGSTACFTLHQDEFYAVTNQTSLESEEVDWTSYYHVVRFRVDNPQPELVIKVFWRRQHLEGPINDAWTDLGFQIDQRTGELLLVECRKEWANGGSKSIRTYYTQSLHRVRLKDLKEGMRHPPTNDRLISTLDETSNSRYEEPGVRIDRYVHTEFPATNEETVKEYIRAKTKWNRYSFNTQCFVDLVTDEFIPEGEWRPRQRVRLRVVSRQELSPLVRDQRSLHPTALMVRPRIRDRDEMELEDSERMFSPSSVYLWPPDDAPQELYDVLCPDGRAGDVSAILGDEGIIYMAGPSREPGSPERALVFISFDPTFGFIGMRRLDGTFAMPKRERKRKTSGGPEQASRTVKDDVSLVAKEEYRHLAGSSLAERPKRLKVEGEAAVEAYNLGPSPDPSTDPAHTRFHAAPNLSTAAEDKPEPDVAVPPQGDATAQALGLDPPSSWPAFGSKTQRSDHFTGPIDSATASGDQQDEGRGKGKARARTPSPPTPAPTTSTHNCTRTRTTWRENAAYLAINQGFWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ12</accession>
    <name>A0A1C1CJ12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_03793</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ12"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ12"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03793"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08636"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="535"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="686"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1494"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="595"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1160"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1665"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1814"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="595"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1673"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1697"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1821"/>
            <end position="1830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT48513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1837" mass="206365" checksum="CC07C96FD136887C" modified="2016-11-02" version="1">MATMELPPLPVPISDFVSYVDKHPKVPAGVAEAVKPFKAFENKLREVYAQQPEHPAASANHLLPVFDNDILAVRARDLANESPAEQDKYLLALPEDVRRKNGTPATVQSLKDFKTNFNLFSESALVDLDWSNVVCAGSAVVTSLLPVDAPHNESKRALRTYYHEDLAPASDVDLFLYGLNEEQAMEKVKQIECKIRDSILAETTTVRTKNAITIVSQYPIRHVQIVLRLYKSVSEILTGFDVDCSCVAYDGKQVWASPRALAAFMTQMNTIDLSRRSPSYENRLSKYSRRGFEVYWPLLDRSRVDPTIFERSFSRVLGLARLLVLEKLPHPNDRDTYLAKRRAERGRPPLPWNARFRHELPGNVKDAQPEDVAEWVEEDEVSNYHTVTIPYGPRYHAKKIEKLLFVKDLLLNAEWNKSKDRETQLHRHPAFFGSANDVLHDCCGFCPKPVTDEDLAAFEEESKIYISGSVTFLRDDPGRQAIGSFNPITDDDWTEMAYVGNTTRLCQAIVDLDLDAVRDWFSSPEVVDVNRRDHTGRTPLQLAVMCSTPEIVQCLIEHGARLVARLYNGMTALHLAAYRGQVQMVKDILDKSEANEEAENAKEDARRDARRSAAVADASSSEDVSHEQDSSADDSFDSAEDFEHETEPDDVTEGSFVKVNDNVSPDEDGGEDEPDVYDVDVLAWDSPLSPLHLAILAGHLDVIELLVDKYGADVLLPVKIADEYNRKQAKAAILSITLALELPLQQANETVAALLGHGATFVQADMKHISALNYAVNSAKTLILETMRSSGPSHFSSACNFIAISGWFDTAKVNTPLLTAIRTGKPEVVDSLVRWGAKTHIDFESYAQAYRRSFERPSNDPERVKKTFQKTVEQPIIVALQHDMVEFVAQLVAAGEDVNTLPTKAYKYLEYRYTSWNSAGQSLLDLVEDRIASLRQYLQAGDAQTLAKPAALDEDSVYLDGYEAGSYSYWTAFEDLRAAKSLHQYQTKQYEKELSAKKQSSDEARKKAAINNTIENLVNLKSKLCEKGAKSFWDLHPEVRKEEVPHRLPYRRGFNHHSTEPYKTKISFKVPDLTPEKEANYIKLFEAAWHGNVETVKSLCLHGDRPLHIAVYDLRGFSPFAIAAIRGHYELARVIVEIAKAQYQPDDKSDRYHYRVCTDGDDHSCSDESSDDERSEGSDHVRLHAEIVDEAFTVKDVAALEATTVKSRVSPSTMVAWNCEVARALRGDVDPRQVKDVFGGSFGDHHVYIGDQSKQSWAWFNAVFGATGQAMQRSLVRYAIFTDDMTLLKFLIKIGNELATQIPDGKNDSLKVMHISQDDFGLAVRLGRVEMVGEIIKSTGFGLPLQKVFQKSGIKLEEKPKYYQGLSVRGRKRQDWAEAGRGGRRSRRVESDVGVPLLAAAIEGNPDSTEFFLTDAPLRRYLEFAESLKDEKRIQALAQAKGGIKGTLSSWLSTRNQLVLHVGVLSPPQKDGGQPTFDLLLEKMPDALEVRAVDGKTPLQLAFEVQRYYAAKKLIAAGANQATKDRVGRNIMHTILDTIPVDKPAFLGSVINMLDKTVLVPLLLERCSTIESTGNTPLAVFLGRITSRTGWEESLKLLLSLSEGKDLEKMDGAGDYPLHTVVRKSHRELVRFIVEFRPGLLHWENATGMTVSDMVTTSYLRHQIDHPPTLSESETRHIEDRPASEFKDTAGSSNTEVENEDEDDDDASGRSNEWKMRRFINALVAKYPAKRKLVGLHDANEVAKRLALQQQKQNEENRRRERLGLKAVGLRHQYRYDNDVADPTEDPQDEVADYISRGKGFIKWDEMVWRKTEAGETTGLDGKEIEREYDADLQDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ26</accession>
    <name>A0A1C1CJ26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRM7</name>
        <name evidence="10" type="ORF">CLCR_04144</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ26"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04144"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08641"/>
    <dbReference type="eggNOG" id="KOG1099">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106339">
        <property type="term" value="F:tRNA (cytidine(32)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002130">
        <property type="term" value="P:wobble position ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="126"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="279"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="378"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT48519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="422" mass="46657" checksum="EEF7B7D810BE8EE2" modified="2016-11-02" version="1">MGKSSKDKRDAYYRLAKEQNWRARSAFKLIQIDEQFDLFSYAEPEKCTRVVDLCAAPGSWSQVLSRILIKGESFGRRAWCERMERFNRPQMAHLGQQPETDLVGDLNSLHLDGKPSERELKPRANVKIVAIDLQPMAPLEGIIQLQADITHPSTVPRLLHAIDPAFSPTDSTHLVDLVISDGAPDVTGLHSLDIYVQSQLLYSALTLATKVLRPGGKFVAKIFRGRNVDLIYAQLRILFERVSVAKPRASRASSIEAFVVCEGYRPVLVRSRAGEEVLWTPEIGDAPEPANGDISEQGGQDDTAAGEESRNEPTASGNSPEPVGARTQGQSRHRRPDGVVELHFPDEELDPARYIAPFLACGDLSAWDSDATYKLPAGHVSLDPVQPPTAPPYKMAIERRRIEGGMYGKTKKRDKLQSSDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ63</accession>
    <name>A0A1C1CJ63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW-domain-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ63"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ63"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04294"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10273"/>
    <dbReference type="eggNOG" id="KOG3294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27370" checksum="D278B1853D7C9168" modified="2016-11-02" version="1">MSINWVMLDGKGSFVLLPAERIIHKTTPRVGLAITTPTTYPGNSPLAIHCSSGTVYLTNQRIVYLPEKPTTELKSFSAPLLNLHDTHMTVPWFGPNAWQAVLQPVPGGNIPATQAAIELKFTFKEGGAPDFHSTLERIKERLQQVVSTARENNLSGQTQDRFLGNVNLDNVHLDQLPSYQESGRDRVAPENADETGGAVASPVARTQEPRRGGSPVQDAQPPSDAPPGYEETQQQSIQAELDRRLSQTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ68</accession>
    <name>A0A1C1CJ68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ68"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03890"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08617"/>
    <dbReference type="eggNOG" id="ENOG502R9P3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4120877at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650836" evidence="2">
        <location>
            <begin position="21"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="668" mass="68687" checksum="067CB4116D3A5930" modified="2016-11-02" version="1">MAPLHSFLAFASVLFSSTYAYVDFGSLTLPVEPLYEPTPRPNQLPQDYDLRHEILPSMITAVAPQVTLVANGTHETMYSLHYHHYFSKTRQGRGVFDKRGVFAGDPPIATCTPCGGDAATSAPVSTSTSTVPCTTRTYHGVFDYPPDSVISACYNTNYTGVFQPTTLTSTALPCCFTIPASCRLNSTLFANTTTSFTASTGVFRPTSTSTSTTRRLTTTSSSSRFSLTTPTSTGGSSSQTRSQGPVLNSGTSSSSATSARTTVTVISGTTTILTISMSSTATTGSGSSFFSSNPYTSPSGSAATTSYSIIVISSTTITLTPSMTTTSNSGRGGVSDLPTLTVITGTASTTSSVSASVSLSTSTKSNTIIGCGEASGSGIIEGTGTVYLADTSVSASGTASGYATSVSGCGTIVATTGSFSGIASITGCGFGYGTGTLTGMGTVWPWYGGGLLSFVSSGTVAGAGSFVGCGTITGSGYFSATAGSPVLVTPSSTARPTRTISVYLSYCPAPTAGTSADSMFRLASSYNTTQGISPAIANLNGTSPYTNSTANSTFALNSTVNANPLCQVCPNSVGVCCPPTVSCSADDGKCPLFALENSGNMINGYLIQQVVNSSAPVAGRRKVRALDKRNVHDLGIGTDLVRLEMEVEQGLKKHKNKDKHRRTHHKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJR0</accession>
    <name>A0A1C1CJR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_04542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJR0"/>
    <dbReference type="STRING" id="86049.A0A1C1CJR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04542"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03216"/>
    <dbReference type="OrthoDB" id="4132787at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="386"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="737"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="771"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="737"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="831" mass="92063" checksum="B2BE0DD24221AAE2" modified="2016-11-02" version="1">MTPQHRGDQPKARKRGVLACLCFDGDEITPILIEKIRQIELLERRLVELEGRKTPLYALPPPPPPPPPTASITAGPSLPTTKPDWELFEPSLPGAGFQGQADEEEHGSRQPTRLSSLQRAPGGTQAQHSELDTRLDHRIDENEVSQKTLSPIANSDAISDRVDGMGAVPGDITELTDLDAEQIGYFGKSSTLSFVAHVQKLLVSSRPIPSAGQSATTPIQPARRALPTVVPSEEYSVPPRKEADALLHRFWQKVYPLYPFLDRDQFHRQYSEVWSSSPPEALTSSTVIESSLFTKHAGHRRLLQDKVPDSRRFHILLNAIFAVSCSCDTPNTGLSQAHRGEIYWQRSKSLLELDFDIFNRPNLQFIQAMLYASIYLQSSTELTGACWNLVGVSIRMAQGLGLHNRGSHKIEGTTCGDVDRQPRSHDTLSCLRCRIWAGCVIMDRTLSTTYGRPAMVADALAEQLQLLPSSPVEPAEALTPTRPSDDNGLASFVYSVRLQRTLSMITSTLYETPSSDDVHLPDSTSFGIEVFRAPHLMQKIANGDFRSLVQLEGDLCRWETSLPWCLRVPASAQLLSPDETFTPTFDVQAVALRARPILLHHAQPGVGFRGRKGHDAGSDDENISSALGRALVNHGVHMCIKNAQELVLLLEWVHRAYLEAIPEPWYVIFWLYTCGMVFLLDRHCNISGNDCMSFWNPCLDTLRLYQSTHRTAVRSLKLLELSERSLFPASRAQARAQTSTSVAPQSQQPVHGPAQGHARYQMDAAGGGGVRVGLNPETLSPVAEQPHSISTWSGPEGELPSLCLDDQIDFAWLGTLPFDLYSDENLDELWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJS2</accession>
    <name>A0A1C1CJS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04639"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03132"/>
    <dbReference type="OrthoDB" id="4154172at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="657" mass="73661" checksum="B912DFA42A4ED0E4" modified="2016-11-02" version="1">MAPATEVDPQRRKVADRIRAFQDVQQLETRIPSFQLPPRVLTQDQDSIAHPGSDWPASRVSRDESEDVRGDGVTPVAEILYQDVRDLEKLVDQGDPQHHLPFRPFTSMDGPGDERGLSRRGTERHASLQLGRQNRLMEDVTEDPALEIAMARSRLRSIAAPKQQPVQEGLGTSRSRPLTMDELNTMLDDAIKSNSPKPDVSSDEQSANLAPKPGFVLRRASTRQDRRRSQSRARVSRRTTESVEPRTSDESTRVRYDGDEVAPPQQDAARRDTLQATSPAAPRLTPVATPVTELSPVKQRAAIFESLAKKAEPSGHDSICRHFGHDHDPTHDHTHHHAGPIRKEPKKVHRIKFGDRIEERPATPLIPLNLPAMVTKEKTTRPLPPPNREGEFHPLVDPPAEEPNHDDVFKEEAQDRKPSLTWPFKWGLFSKGASAPPQESEPSTPAVVEPEDQHYPTTRPSVVRSKVQQILQAVEQKDDAEQRRREAERERITRRNSRAAPPSRRQTVVKRVEPKQEMTTEPAPMEIPQREQLQGLKAAAGPDTKTKTPLQNAMSEKQVLAPPVRAEQDSDSGASPQKSLPQTPVRGRPSLAYQTPEQKHSVERQFNLSPTRSASKHRQGVKVEVEIRDSPERDARERGEKIVIIRAGVGSDMDEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK56</accession>
    <name>A0A1C1CK56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF605-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_04753</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK56"/>
    <dbReference type="STRING" id="86049.A0A1C1CK56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04753"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03045"/>
    <dbReference type="eggNOG" id="KOG0917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="13"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="496"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="219"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT48866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="56962" checksum="C1B40A8AAF1AA321" modified="2016-11-02" version="1">MAAQVPAALKTADITRFAHRAAQLEKAKPIIAYWCEYWIVNQILSRGLHNADQESLAYTTALMDKLEQFKAEHAQEPAVTDDVVGKAYVEQFGLETFERADNAVRANKASRQTADTFQASATFLDLLQIWGPLEPEIAAKIKFAKYHALRIAKALKAGEDPNLSNPKPQTPVDEALPALDPSDADVQALEGHSATKSRQPSVVEVPDEADKIQKTLAQKSVLDESLHPSRDPSLPPPLARQPTVTEVPDEADRMQSTLATQSSIDQSLHPSRAPSVPPTNDVSPLPDQDATNFYTNTADEPAEISPLGPSAERKPSVGGNYFPVVPPGPGSEPNLPSAPTTIGPAAPLELPSTPTTLGKVRTDLPSASSEPSVTSASARSDLGAALNAPPSRQSPPLPPHRHGTLLPQVSPGQPSTFAPNFQPQPPQQPIIPPQARQARGPVPPVPQFQQPPQVPQVPGPPPPVFAPSPVHPPPRQAPVATIAPHPQPSNVVIDEEAVMKAQKHARWAISALNFEDVPTAIRELRGALASLGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK80</accession>
    <name>A0A1C1CK80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Allophanate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">atzF</name>
        <name evidence="3" type="ORF">CLCR_04779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK80"/>
    <dbReference type="STRING" id="86049.A0A1C1CK80"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04779"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02996"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF169">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="83"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="546" mass="59176" checksum="794DFE051B086E7F" modified="2016-11-02" version="1">MGSILNPTRTAPSSRDILSLNVEDLHASYAARKLSPVDVVRHVYAKISSYPDPAVWIYLVPLAEALTRAEELVATYYQHDSHDDRSTDPLSLPPLFGMPFSVKDSIDIAGLPTTLACPSFAYTATETAPVITRILAAGGILIGKTNLDQFATGLAGVRSPHGAPRCVFDREYISGGSSSGSAVSVAASLVSFTVCTDTGGSTRVPAALNGLVGLKPTLGTVSAVGLVPACKNIDCVCVMGRTVRDVHTVWDVIRAFDERDVFARRHVPEWPAWCDPVRFAIPPVHELRDHLSPAYAALFEKVVAALRSQSQSQSQSQSQSQSQSQSQSQSQSQSQSQSQSQRHSQSQAEILQTLGDSPSWCIEATTPFDYTPFAAANQMLYDSSIVAQRLLAFDAYISSHGLDADDLHPAIRATFRQALDNGFSAVRAYDDIFALAELRRHAEVQFRDCVDVLIVPSTVDHFTVAQLEEEPMVRNKVMGRFTNFVNLLDLAAVSVPVGWWVGANGKKLPFGVTVIGQAGKDGEIMAFGERIMRMMMAGEEAVWKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKH2</accession>
    <name>A0A1C1CKH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKH2"/>
    <dbReference type="STRING" id="86049.A0A1C1CKH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05099"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02985"/>
    <dbReference type="eggNOG" id="ENOG502SPDA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4151352at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="63"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="246" mass="27539" checksum="D93BFDC49B48A695" modified="2016-11-02" version="1">MVTSMPPAMAPWNAPQMHSMAYSDHGLQYHQQHMMPTYLPVPNAMPAVPQMPREPLPKPGQSGPWSNDEDSILMEAKLKGMSWEEIHRQHFPGKSANACRKRHERVLAKVRNTNWDEARIQRVTDAYHKHRSSIWAPLCNELGESLSDVEKVMFQQGLRNLRNPSRSSHTRNRSRASSGHAGVSEYERGSSLDEPFDHADDSGISLGNPLHSRRPSEMGPAMSSSVESLPSVGHLLSEAGGYHYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKT4</accession>
    <name>A0A1C1CKT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Asp/Glu racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKT4"/>
    <dbReference type="STRING" id="86049.A0A1C1CKT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05131"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02801"/>
    <dbReference type="eggNOG" id="ENOG502SN3M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414270at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="BLR3294 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267:SF1">
        <property type="entry name" value="BLR3294 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015736">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="246" mass="26729" checksum="38B8E23B5898B462" modified="2016-11-02" version="1">MRVIRLGVLVPSSNTAVEPLTHAIVSSIQSKDVDLSVHFSRFRVTTIDVSPVANAQFELSPILNAARLLADAKVDVIGWSGTSAGWLGFEHDEKLCAAIEAETGIRATTSVLALNSILRSLGVISFGLVTPYRKELNSLIRQNYAAIGVDINATWDRHLGMTDNNEIGRVDDATLDGMVMDVASNGANVLSTFCTNLRAAQRVEHWEESASVIVLDTVASVVWGMLKIVKVDTRLVTGWGYMFEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL07</accession>
    <name>A0A1C1CL07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL07"/>
    <dbReference type="STRING" id="86049.A0A1C1CL07"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05142"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02746"/>
    <dbReference type="eggNOG" id="ENOG502S165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="240" mass="27227" checksum="E9340D90C5BC7B80" modified="2016-11-02" version="1">MSYEPVPTEDGDAKSQTRQDNKPDSGGVGLARVQQFFSFTRYFIAATALLAIILTVFYLARDARTQANDDSQLERPPESCGSSAAEAVSRGCVFDVMEFAWVPSRCFDGELLENFLALRDWEWYLDAAGTEAADKDAVAQGRHDEVFVTQQYHIYHCTYMWRKMHRAFLARDVLDGYIADTHHTAHCELQLANCWRSGINDTGTSIYVKYSDCPASRQAQDLGRFGWYRMIGGQRVHRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL45</accession>
    <name>A0A1C1CL45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL45"/>
    <dbReference type="STRING" id="86049.A0A1C1CL45"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05231"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02724"/>
    <dbReference type="OrthoDB" id="5414372at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="150" mass="16751" checksum="141D75A065A4A4C4" modified="2016-11-02" version="1">MSRSVSPLPPSGRWNSPGLTDRSSTPNGLYAGARNYHNDNDDQWAAAKARSAQVRGRPSIQTKNEGFFLRSKRKISTLPVFSPYTPLSANWKDPEKLGRSRWYPRGGGNLSRIKTFAGNVLRRFKFLLIILSVVTLTTVLLSETSVFPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLA0</accession>
    <name>A0A1C1CLA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc/cadmium resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_04723</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLA0"/>
    <dbReference type="STRING" id="86049.A0A1C1CLA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04723"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02659"/>
    <dbReference type="eggNOG" id="KOG1483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000021">
        <property type="entry name" value="Solute carrier family 30 (Zinc transporter), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000026">
        <property type="entry name" value="Zinc/cadmium resistance protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="12"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="344"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="424"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="501"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="530"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT49280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="576" mass="61799" checksum="625F6506778DD54E" modified="2016-11-02" version="1">MGLTKTQRICILLGIDAVFFLIELICGYAVHSLALVADSFHMLNDVLSLCVGLWAVRVANTGSSKMYTYGWQRAETLGALVNGVFLVALCLSIFLEAIQRFVEPQKVSNPKLVLIVGCLGLASNVLGLFLFHEHGHSHGGEEHSHDDNPARAAEEGHGHVHADGETHKMTDEHGNIEDILPQVRIAGYRASDSRKFTKSDEENTTISARSTNTTHRKPTNGEVHGRHRRRTSGSFGRGFGSVDNIHIHPASFRQDIIQAARLEERSESESGEEDALLIDVDSPVDRSNTFAEDHHASPSRSNRVSGYGSINNRKKSLDYNHAAHNHNHQKDASGSAHGHGGHGGHGHSHGDLNMRGVFLHVMGDALGNIGVIVTALIIWLTTFPGRYYFDPAISLVITLIILASAIPLCRAAGRILLQAVPVGMSIDEITADIESLPRVMEAHHLHVWQLSDTKLVASLHVKVDCEVEGAGSASYMHLAREIRSCLHGYGIHSSTIQPEFEAPHLHSPNGAGDDDGAVGAAGSGGSGSATPKNNANGSKTASLRSEGQPVCLLDCSDACAGSKMCCPSDGSKNGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLR0</accession>
    <name>A0A1C1CLR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_04731</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLR0"/>
    <dbReference type="STRING" id="86049.A0A1C1CLR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04731"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03309"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF132">
        <property type="entry name" value="POLYAMINE TRANSPORTER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="140"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT49392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="589" mass="64691" checksum="267735967D03B270" modified="2016-11-02" version="1">MASPRPQSPRDTRSPDRDLAQHPTLNLQLHRTETRATLQELGVSETSPRLDPNYPVLNRPESPIFPEEYTLETATGLVPQATLEQIRTRASTVATRRRTSSIVGPDVEKQGVEEPVEFVTFTIGDTENPHNWNRWFRWYITLVASGLVVCIAFGSSVVTGGLGLVEEKYNVSLEVAILTCSIMVLGFAVGPLLWSPLSEIIGRQPVYIISLALYTIFNIPCALSPNIGGLLTSRFLCGVFSSSGLSLAGGTIADIWNIEERGMAIAYFAAAPYAGPVIGPIVGGWINVGTHRLSLIFWVNLAFAGLVLVLMALIPETYAPVILKRRAARLRKETGDLNIITEQEKTKLTFSEIVKTSLIRPITMILTEPVLDLMCMYVVLIYAMLYAFFFAYPVIFGELYGYNDGLIGLMFIPIIIGAGFALVATPQFEKQFRRTCAQRAPTAEDRLVGAMVGAPFIPISLFILGATSFKHIIWVGPASSGLAFGFGMVLCYYSVNNYIIDSYQKYAASALAAKVFLRSGGGAAFPLFTTQMYHTLGLQWASWLLAFIGVGMFFIPFGFYFFGAAIRARLNKEEVEEYEKNGPVAPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM85</accession>
    <name>A0A1C1CM85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07817"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="85" mass="9558" checksum="B7A118655DD8DC0B" modified="2016-11-02" version="1">MAVDLSRLDNVGIRLEEGTDRPIDWARQPPSGPRPYSFGNSGRRHAEFTEHDDRELVQWMVAAKMAGLRAGDILDELSALVRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CML5</accession>
    <name>A0A1C1CML5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CML5"/>
    <dbReference type="STRING" id="86049.A0A1C1CML5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07585"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09960"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="227" mass="25012" checksum="A2CB62C556E67CA7" modified="2016-11-02" version="1">MTFQKAMVWSSHTVRRMLYTLFLPLTAIGYALSSRDPPFPIAVPCIFAGLVGFGANLAIAECFALLMGTFDTSDLQPGMTGRPARKSITGRIREQRTNFSCYPRVSAGVAVTQFLMFVFGAVATGIGGRVERRYGAEQSAGIVAGVLMALTLALAVVLYKWKSVQMIPVGRDRTREEDAEGWEPVILGLPSGFTRKINTLEAGTYSRWSEIRRRNHLTTELREVEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMR5</accession>
    <name>A0A1C1CMR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMR5"/>
    <dbReference type="STRING" id="86049.A0A1C1CMR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07250"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08721"/>
    <dbReference type="eggNOG" id="ENOG502SK4S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.520">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.90">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10910">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650910" evidence="1">
        <location>
            <begin position="18"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="91"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="408" mass="43916" checksum="1B547E21196819BD" modified="2016-11-02" version="1">MRILCFYTLALVSVASTCSPGPLIPDQHEVQGYIQRRAGLASATPTSKTGLRNVHIFNGHTFRPGWLAMQGGKITFDLHNVDSWIDGQDGYLIPGLIDSHCHPASISDLATLSSYGVTTAISMGCPSYPLCASLRDQPGLPSFFTASAGIVGPNSTHALVMHADPDTLIRSASQAPQFVSWAFGNNSDFIKIITETNGPDQATQDAIVSETHRLGRQAMTHAADIRSYLRAIASGTDGIQHTPGDGNITPAMIEDMRRNGQFIVPITMVVKAFLNSAVLPLSSYNKRSWQTVIGNLKSMHRARLPLLVGTDAVSLNDPFAALVKNPLGSTMHDELEVFVNEVGFEPAEALRAATSLPARLFRLADRGLIMEGKRADLLLLASNPLKNISATRGIMKVWNGGIEYNSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN53</accession>
    <name>A0A1C1CN53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN53"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07721"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="123" mass="13240" checksum="F6F8508B5BAD513A" modified="2016-11-02" version="1">MPSLAVGWVWKRPEDEGPEGDCFPNGFSYASKPLCTRHRVDCNVPLLMVPSPVAAAAAPLARLASLGCILLQDKVAMDIRGDAGGGYSDGGEFSPWKDIARKEYVAYLSKGRSAMLAIRPPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNR4</accession>
    <name>A0A1C1CNR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_07208</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNR4"/>
    <dbReference type="STRING" id="86049.A0A1C1CNR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07208"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09037"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF5">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="185"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="185"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="294"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="416" mass="46388" checksum="0C11156FB0E33C46" modified="2016-11-02" version="1">MGDMAGIDTELPSHHYASYDNLVDLELSNIMTRASFSHQTLDILPPSVSQLQAYHAQQHQPDMHPLLKLETQGDVSFELLHHSRSHIMPCDTQLQLSDFDLGSNWAPSVCAYPQLINDGVQHTPDTSGLPLFSYSTYPPSLPQPAGQYFVEGNIQSPWSSSPEYIHCAPSASVAHDEDASDDKPYARLIYEALMQAPGHRMMLREIYEWFRHNTTKPQESGSNGWQNSIRHNLSMNKAFENDRDSARGSSRKATSVWILTKDAIDNGVQSTTRYRKTGAGKRPLGGRMPAIQRQRAGARGGRAARNSAKKRHQDLSALTDPASTASPSTTSYSDYGDYPSFDYHELQPAVRSWPMTPVEDNLAADENNLFNSLSPLSKLDPKSQNLAYGEENMHMQNALLQSMRAQHVGDLIRFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNZ8</accession>
    <name>A0A1C1CNZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glyoxylate/hydroxypyruvate reductase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ghrB</name>
        <name evidence="7" type="ORF">CLCR_07342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNZ8"/>
    <dbReference type="STRING" id="86049.A0A1C1CNZ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07342"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05756"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="37"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="157"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT50227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="363" mass="39274" checksum="C0CC434134D982C4" modified="2016-11-02" version="1">MSSSSDVKLAVLDDYAAISSPHFQLLTSQIQIDSFPQTLQARVPSDHDALVARLKPYTIISTMRERTQFPRSVLAELPNLKLLLTTAMKNAAIDTAACKDLGITVVGTSPKRNATKGYDATNEMTWALILGLAKDVARGDAVVKGPSPTASNDPNAHVGGWQTTLTFGLAGKTLGLLGLGKLGTQCAVTGHLGFGMKVIAWSSSLTQDKADEAAQGRGLPKGTFRVVGSKKELFEQADVLSVHYVLSDRSRGIVGKDELSSMKKNSLLVNTSRGPLIDEAALVEALEAGKIRGVGLDVYDVEPLPKETPWRRSGYWGEEGRSTVLVSPHMGYVEEETMHDWYEQQAEAIKAWLNKEEIKGIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPI0</accession>
    <name>A0A1C1CPI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPI0"/>
    <dbReference type="STRING" id="86049.A0A1C1CPI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06964"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05601"/>
    <dbReference type="eggNOG" id="ENOG502RY60">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052567">
        <property type="entry name" value="OP_Dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40202">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40202:SF1">
        <property type="entry name" value="HD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="308"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="489" mass="54513" checksum="74B4E44437BF76CD" modified="2016-11-02" version="1">MLSEEQIRFFHLSGYLILRDVLSAVETQDVQKWAQEVHDWPTDEHSPWMPYEEINARGETVLCRTENYANSHEGLNGLLRGRKLLRLLEQLSGEQMLLFKEKINYKLAGSGGFAPHVDSTAYTHIKKIKHLAILLAVDPSNMTNGGLEVVKGSHEMDVPIGQDNCIKPEWARQQTWTPVELAAGEVLIFGSSLAHRSGANHSSLDRKALYATYNCAREGDLHDQYYAHRKAVWPPAQLRKKGETYQEGALRYGYGSPMLSVDAGKQLVFDEERSPSRLAASKATSQIFEILNTYGQSDYIGEPISQVEHSLQCAYLATRNSADPQTIAAALLHDIGQIIPEANAEKLLGAKVQNMHQEAGTGLDSKPSDSVGRVAHERLGAQYLLALGFPAKVAELVEAHVPAKRYLCATEEGYYDTLSDASKESLRFQGGPMSPEEVRAWQEGRWPAEKAHLRRWDDGAKVVGRDVPGLENYRHILEEVLSQQLYSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPM7</accession>
    <name>A0A1C1CPM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07724"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05555"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="149" mass="15345" checksum="60E99980C07D874A" modified="2016-11-02" version="1">MIVEAQDEKRREDAGQGLETRLTGDGSVADQENGNTVTVTAIETGPERGIGIGTGTGIGIEAGDTEMRTGRAGARGVGAATGTEIPRVCTTYLQGVDALAHTIQITEANAPFDIHAQGLPRETVAAHRSGHGPLSAEAIMTGTEHETGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ51</accession>
    <name>A0A1C1CQ51_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">V-type proton ATPase subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ51"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ51"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07517"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05400"/>
    <dbReference type="eggNOG" id="KOG1664">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="249" mass="28418" checksum="93B0CDC20847A650" modified="2016-11-02" version="1">MSSQALSDDQVVSELKKMTAFIRQEALEKAREIQLKADEEFAIEKSKLVREEIAAIDSQYEKKFKQASMSQQITRSTMANKTRIKVLSARQELLDKLFEEARKKLADTGSKSKNYEEVLKGLMLEAMYLLAEKKVSVRCRKVDKDKVQSAAKKASEEYKKHMGSESEVVVDEKDWLPEDSYVPRPYTTQETTVTLTSVDRAGGVFVLGSNGKIELNNTFDERLRMLESDALPSIRLTLFGDNQNRKFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ83</accession>
    <name>A0A1C1CQ83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc-regulated transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_06981</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ83"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ83"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06981"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05363"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF24">
        <property type="entry name" value="FE(2+) TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="390" mass="42149" checksum="4DC41C92451D94C4" modified="2016-11-02" version="1">MSERPQCGGGGLSEDDYDLPLHIAAVCVLVATAFVHLVPTAFSSLTDPCLPALLTEQYPAMPGVIMMAALFALFTIEMYLKAKVGGHSHGGPMGHGTVALAHQGARPGTVDQQALPSYGTAARSGEHVEYADYEKPHAYTHTYEVTPASREEMEQYNNLADMPPWFQVFYAQYVRQREELKAMIVAITPRAAALPAETSSFDDRSSITLSDTESLAGEATLRRMNLNITLLEGGILFHSIFVGMTISITSDGFVVLLIAILLHQFFEGLGLGSRIAAVPYPNKAVRPWILVIAFGLTCPIGQAIGLLTRNSYDPSSAFALILVGAFNAFSSGLLIYAATVDLLAEDFLSDEAQLTLTKKDKIMAFIYVLLGGRVEASRPSDSVMYVCRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS79</accession>
    <name>A0A1C1CS79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_08742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS79"/>
    <dbReference type="STRING" id="86049.A0A1C1CS79"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08742"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06732"/>
    <dbReference type="eggNOG" id="KOG3847">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF14">
        <property type="entry name" value="PAF ACETYLHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651009" description="1-alkyl-2-acetylglycerophosphocholine esterase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT51354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="375" mass="40501" checksum="468AA0A3A1D7C27A" modified="2016-11-02" version="1">MARFLLMFSMPLAAWCQLITLPSPPGSKVYVSEFPLTDHSRVDPLAPCCNESRRLMLSLFQPANCSQTHQIPYMPPATAASHDAMFGFLGIPNGTFESFRLETCPAPPKNTDFPVLLFSTGAGTSRLVYSVLCQWVASMGFNVISIDHTYDAPIVEFPDGTIVPAANLTPLEDLQKVLTVRTADVLSVLKAISNSTMTKELGIPLFRTKRVGVFGHSLGGATAADAMLLDTRLVGGLNMDGSVYGQAVNKTQKAPFMIFAAQHHNQSSDATWAAFWQQLKGTKLQLEVNGSMHGTFVDYPVLANSLGINSTSVPAVAEFIGSISGARMFNILRSYIGGFFQEVLGSTQVKLLDGPSTQFPEVSFMNRSLSTAATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSB9</accession>
    <name>A0A1C1CSB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08917"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06690"/>
    <dbReference type="eggNOG" id="ENOG502S05V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3254104at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="286" mass="31864" checksum="D3F410E2447118C0" modified="2016-11-02" version="1">MSTVFGKRGESAQTARPSLSTVHSDDGRRHGEPEAVKRAETAPIHGGKPSNSLKRTDSAKPSVLSRSDTHVSKRPLVRVPSVQTRYMEMLLHLDEIPRFYNILASLFTWIILAGFLVVPGTFTTFKESEAFQDADNNDDDEVTHAIVHSIANIGLLWLAGAFCIVGALGCLALWFRWRENYVWLINRVFLPVAMNSVAGLITTLVNIYTAQHGVWSITARITAIVIGACMIVAGLLFALYNFWALRRVRKTHERQMGLEAQHHDETLVEKVKRKAHEPPLQSGSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSF1</accession>
    <name>A0A1C1CSF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gamma-butyrobetaine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_08483</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSF1"/>
    <dbReference type="STRING" id="86049.A0A1C1CSF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08483"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06659"/>
    <dbReference type="eggNOG" id="KOG3889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF25">
        <property type="entry name" value="OXIDOREDUCTASE AIM17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="204"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT51423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="497" mass="56130" checksum="BE52CEE80777C717" modified="2016-11-02" version="1">MPTTHIRLKDIAKLSGKHKGFGQRVRRPTERFQKIEAGNRLSAAAKNPRQEDLVNNANEASGSDAGTTSRPSLDARQSPFPIQPSKSQMLSEGMLLDARGKPIISPILARDACKCADCIDPSDRQRNFSYANIPTDISFSSVSRNPKTGESLVRWRNDIPPHSPGKASIFDPDTVASLEKTFRNPLWSLYNVPQRLWDSESFTRETNRIDFNEYQNDDDALADTMYLLWRDGLVFVDGVPESDASVSQIVTRIGPLMNTFYGTTWDVKSVPDAKNVAYTAKYLGFHMDLLYMREPPAFQFLHCIHNESVGGESRFADTFKAVDLLYARDPAKVVALMDQHIRYEYDNDGYFYSDSKPTILRLSELNVPKRPTHNAQSPAFMSDVGRVHWSPPFVGDLQQTQHDELVRLVSASKAFSDILERPDMVVQEKMDSGTCVIFDNLRVVHARNAFDLNSGRRWLKGAYLGRQDFVSRASGLLSRFPVEIAFKETQPGDWPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSX8</accession>
    <name>A0A1C1CSX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR02452 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSX8"/>
    <dbReference type="STRING" id="86049.A0A1C1CSX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08861"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06488"/>
    <dbReference type="eggNOG" id="ENOG502RY8X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9985428at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="2">
        <location>
            <begin position="98"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="324" mass="35628" checksum="64B9B90C395606E4" modified="2016-11-02" version="1">MTVQSPNGAAANTDDKALASSALRQSKLSWSSDGRLSAQPPVSPKSEDRDELVKVAKQTISVLPGLLLTRPDAKPDGYLYDKDRVAPLDQGFCPRLPKTKVRVISSDTIDAALQLRRAPSDKPICILNMANAIHAGGGFRTGALAQEEALCYRTSLHFTLKLRFYPLPDKAAIYSPNVLVIRDSLANGHRLLDCRDPSKLPVISVVSAAAIYQPSVGCKLCQPKELSHNFYARGEDRNLMREKIRVIVRTAIRNKHRKIVLGAFGCGAFRNPPKEVAGLFAEVLQEPEFSGGWWEDVVFAVLNQGSAGKMNFDWFERELSGLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTJ8</accession>
    <name>A0A1C1CTJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C6 zinc finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTJ8"/>
    <dbReference type="STRING" id="86049.A0A1C1CTJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08340"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06286"/>
    <dbReference type="eggNOG" id="ENOG502T49K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="57358" checksum="02DBA037FE1EBE10" modified="2016-11-02" version="1">MININDEFREPEAGPSPGPELKEQSTGPRYPQPRPIIIAARKAGSEYPAKVKTEDDASETALQKIAPTQRSISPPLRYDIPHQSMCFFLNLFCFQAGRLYSFPVLDFLPDMLRTAEDGSCVKKAAMAVSRMTLADRYSGKDVRLQTGREYGQALRLTNATIRDTKASIQDETVLAVWLLGLYEMISVVLTHGRTNADSPTLEEEWQAHLLHVRGAMNLLRLRGMSQFTTARGEKIFRILKAAIQMRLFILTSVFSKDFDNLEIDMYQDEHEFVPSPTANRASAYFHRVARLLEKVKQFLAQIPLQPEKTRAMAEVFLKSGETLDEDMAGWSKDEPGWDMMRVRAPTAGTMWALYPSHALYHFYSFWVFLYWLRFLAARYKLYEGLIELLKLDVAQSSAKPRTAPSRVDIRMSKYRTIIQMTASELIGLTAYALGDVTPTGDFNSSISGQHPRQGFQEINVVAAMQLVLPLKMLQRSEYLTATQKGAVDLAISHIGDGFRRQPLMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTJ9</accession>
    <name>A0A1C1CTJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxal reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">plr1</name>
        <name evidence="3" type="ORF">CLCR_08829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTJ9"/>
    <dbReference type="STRING" id="86049.A0A1C1CTJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08829"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06301"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="343" mass="37521" checksum="0C64CDB389A6D8EA" modified="2016-11-02" version="1">MSATVKLVGKPIGPVGYGLMGLTWRPNPQPAEDSFKAMETALAQGANFWNGGELYGPPERHSCHLLNEYFKLHPGDADKVVLSIKGGTLPGQLKPDGSAKNVRRSVEDCLKILDGTKTIDIFECARLDHDVPLEETIGTLAELKKEGKIGAIGLSEVKASTIERAHKIHPIAAVEVEVSLWTTDILRNGVAATCAKLDIPIVAYSPLSRGALAGESIRRNADIPEGDFRKMLPRFQDDVLEYNNQIVDEVEKLAKRKGVTKAQIAIAWVRALSGRTITTEDGQQLMLGVIIPIPGATKPERVIENTKHVELSEEEMKEIADILKKNPIKGDRYPKMGMAHVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTL5</accession>
    <name>A0A1C1CTL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase, N-terminal domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTL5"/>
    <dbReference type="STRING" id="86049.A0A1C1CTL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08007"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06270"/>
    <dbReference type="eggNOG" id="KOG0406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="550"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="852" mass="93272" checksum="F993EFDF74C48A0F" modified="2016-11-02" version="1">MDAANTHSLQQFAAAVQQYGFANEHDGPSASDDAPNAGYAPAETVNANHNRSYPMNTANGSPNVQTRRQSNMLRNTSNPNPPPTMRSPQQSRPVQTRSSQTPSRNGSMAAANSTPQMQVAQAQANQQQTDNVQDEINSTPSGQQNAFIFRNSSSAFPNGTPTLTRSQSSQSQVYTTSQGIVQTDPWASRYRPNPAEDGVNGTDAGNNDHAETDPAVAANPFSDTFPLIPNPPDLEQWREKLFNVNETLVLSEEEFLTYFPHVDNVYSHRSTQKYKRKAFVSHYWDCRLKGRPSGTPKSDDPNKKKRKRTARERDLCDVKIKITEYFSAEEARKMGLDGNANGADIDLNTNGAMPHDMAGGGYGAADNSALNIVMEDGNQGLGGNLSALGGGLVGTVAPSNNNSTDPNFGLLELPRPLPQGHPGADGKRWYTIQRVRGNPGGGAVKDNHKRDSNANGDADDDIDQSVLDPSLGYDLSHKHSLEESDRIKKNSVQRWMLKEEKEKKRLSKIPIANASPADQVTAAKESVSPSFRASGMAYFTVRSHAAPAPTKITLFANSFCPFAQRIWMALEVKGIPYQMVEIMPANVDSYRPPEMLEVNPEGNIPSIRHGNWGVWESGVVLEYLEDLAMGHPLLPLGNPQLRAHCRLWTDHINRKILPSFYSLLLTPPPSPSGEQPMGMDGMQLDGGADAQMAAAATSAQHSMLIATLQKNITALVNASHATGPFFLGNEIGYVDVIFAPWILRLSRVLSYYRHFPRPEVGTRWRQWVDAIEADDRVRRTVSDENSYHGVYRGVGEDGWCAKDAVKPMVEIHYARKVVAQEGFGLGGDVWGRLPEEEAVHNPGGVQMGQGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTM2</accession>
    <name>A0A1C1CTM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTM2"/>
    <dbReference type="STRING" id="86049.A0A1C1CTM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09084"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06260"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19174at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="227" mass="24894" checksum="5D1E944C89E378C3" modified="2016-11-02" version="1">MSAEATLNPFLLAANTPDPDPRLLPLLRSRPELASAQDAHGYSLLHAAASYNHVGLLRSLVNEFKVDINLKDEDGETCVFVAETVEAVRCLVEELHVDLQVRNEDGMDALEKFESEQEFPEVAEFLRTHAAEASTAQTTRVGAGLAPNGVQHPSTLPPNVSISIGTESDTTGTGDQEPDPGFRQRIEELASREDFHTEEGQRDLRELISDAVRDVGGENRDVRRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTZ2</accession>
    <name>A0A1C1CTZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative iron-sulfur cluster-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTZ2"/>
    <dbReference type="STRING" id="86049.A0A1C1CTZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08677"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06154"/>
    <dbReference type="eggNOG" id="ENOG502QQJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="20"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="350" mass="39474" checksum="F17E54414495F81C" modified="2016-11-02" version="1">MSDEDVFQLEKRAFFSKTWLFVCHQSRFSKAGDYHAFDVAGISFFVVLGKDMKLRAFHNVCRHRAYTVVRKPCGTSTRFSCKYHGWQYDDKGALVKAPKFDESPGFVPEENGLFEVKLIATREGLVFVNFDASTMNLPFNNVKSHVDLGNCSWVDGMDVTCGTNWKTVANEFSNQAQWSQSPFGWFAALRKSKIVRLLGPLSIIKELDDDLWCTMVLLPRSSAEVMVRCDLYAKEGHVAPAKTLEKRKWMLEQELMAVTRSGTQEKISTGPRYFAYQCGGRTIDLFAILAQHQRSEKMAKRKLQPAIRVTGTADIDTEAEALCDALDGAADGPSLETCSRMSSFPHTVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV22</accession>
    <name>A0A1C1CV22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short-chain dehydrogenases/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV22"/>
    <dbReference type="STRING" id="86049.A0A1C1CV22"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08738"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05828"/>
    <dbReference type="eggNOG" id="ENOG502S0SX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="369" mass="40456" checksum="9781647B44789EBB" modified="2016-11-02" version="1">MVQLDVIRAANTALFQGRPFVAVFAGATSGIGEATLRAFATASGVHGKGLRAYVVGRRKEATEEILADCSRLCPDGNFIFVHAKDLALLEEVDKVCSEITRAERETAGKDSAEIDLLFMSQGDFNFSPRRAGYPLIISPDTKEGLEFRVALLYYSRMRFISNLLPLLLASDLPAHVISVFAAGMEGEFHLNDMSIRDPRHWGTLTVRSHVCVMHTFFFERLAEQHRGKLSLVHLFPGMVMTKAFQNPGVPLWGKLMFKIFRPILSVFATPVSESGERTLFLASPQRFPVCRGSGDQPTKAASAGSPNLVVATGTDGKIGSGAYAVDIDGETCHKAKTIEKYRAEGVGEKIWEHTMKVFDIIASGNVWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVN4</accession>
    <name>A0A1C1CVN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5'-hydroxyaverantin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adhA</name>
        <name evidence="4" type="ORF">CLCR_10595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVN4"/>
    <dbReference type="STRING" id="86049.A0A1C1CVN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10595"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10012"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF31">
        <property type="entry name" value="CHAIN DEHYDROGENASE_REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="306" mass="33336" checksum="9EB04436AD5DD7DC" modified="2016-11-02" version="1">MPEYKHTGPVECDVAIDTRKIKDKTAIVTGGANGIGEAYARALVAAGVNVVIGDLDSANGQKLESELPGLKFMTCDTTNWDDQARLFKAAAMFSPTGKISYVVANAGIIRLDEVFTQDVASDEPKEPDLKTIDVNIKGTLFTAKLAAHYFVKQNGTTPSPDQEDTCLVLIGSGAALLDCLRIPQYCATKWAMRGIMHALRRTAFYYGSRVNVIMPWYVKTNILSQKDWDAVSAVGVEFAEAVDAGKCLLRILSDPEVNGHSFFLAARKWAACGFMDLDLDDYKDPLLQEIQEDQIKATPVSAGLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW07</accession>
    <name>A0A1C1CW07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW07"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11037"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="112" mass="11920" checksum="8F44A2DDD05656A1" modified="2016-11-02" version="1">MSSIPGPAMAGPCRSRNVQRHMLFKVTLCRKAAAVHRAGSIGKSKAAQDLDHLKQQGSERASELDLDHLDLEAARCQAQPTGVTCCLEACSQPGGLNSARIAPSKLEIRVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW63</accession>
    <name>A0A1C1CW63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LCCL domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_09748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW63"/>
    <dbReference type="STRING" id="86049.A0A1C1CW63"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09748"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04119"/>
    <dbReference type="eggNOG" id="ENOG502QUEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF8">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="209"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="689" mass="75728" checksum="D45C107229F0BF6E" modified="2016-11-02" version="1">MVRYRDDEEDPAAGILRAEDDPDNVPGSPELHIRSTPDSPTTGTLPIPIWLRESASSFRYKWVPLPVRKAGRAIVTWVKGPQPPRVLRIEPIFPKIQQAPIRLLDKYAPKKKQRVILLMALYVCWFLTWSLMVKQHSTSGFIKGYGRPTNLWCGASFWNEGNGCGLNGNMCRPFSAAHLTFRCPANCEGTHLLEEHMVGNKSLRYQGLVVGGPDPQDPESMAVYRADSFICQAAIHAGITTDANGGCGVATLVGSHTNFASTKANGIESTSFPGTFPRSFTFQHLSSTQAQCPKDSRWPLFVVTAVALVILSLFTTSPAVFFFSTFVIMFLHVGLVSDPPNTANVYEAISKLVERILPASFIAIILYRVAAVPLLTGVTAQIEKTILYLGFCFIGALNNYTFAPLIPIERLTPHDLAQPGAPFALAIIVTVILAIVISQVHFIRISGNMPKYLAIYGAMVVTLGILLALPNLRLRIHHYILAMLFMPGTFTQIRPCLGYQGLLLGLFINGVARWGFASIIQTPAALGEANGGGSNGSPGSWWGAKSPNVTAVVAPDISNITFNWGPLPRDSGVDGVSILINDVERWRGYTDEELYWDSEGVTLKRRHERGDSADGLEPEFFRFAWMSGSQTGLYSKVGLWDEHGRWRSPEEGTTLGSSEQSEVKNWNGEFDDITEEEEGTDPDGRVIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWB3</accession>
    <name>A0A1C1CWB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="3">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_10108</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWB3"/>
    <dbReference type="STRING" id="86049.A0A1C1CWB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10108"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04101"/>
    <dbReference type="eggNOG" id="ENOG502QUM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651101" description="endo-1,3(4)-beta-glucanase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="8">
        <location>
            <begin position="12"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="448"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT52751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="486" mass="50716" checksum="41DFDE2D0B8D3670" modified="2016-11-02" version="1">MRTSLINLSILAASASASYLLEDDYSSDVFADMFDFFTDDDPTHGYVNYISYDQATSAGLYKADNGSVYMGVDSTNVATGRGRDSVRLSTKKVYNHGLIILDLAHMPAGACGSWPAFWMLGPNWPVNGEIDIIEGVNSQSANTMTLHTNAGCSITSTGAFSGSLQTDNCDVNAPDQATNAGCAIDSDDNLTFGSGFNANGGGVYATEWTSEAISMWFFPRNSIPADISNGQPDPSNWGLPKGQFTGGCDIDEHVKDQQLVFDVTFCGDWAGSVWSTDSTCSALGSTCQAYVQNNPSAFQETYWLINGLKVYTDNGAAPTQTTAATGVTASHTATHTSLAGFPTVITATTFVTLNSPPSSSSESIATLAAISSTATETAIGAATFTNPTSTTISTPIQTPSATRFVTVTAINNTPSVAADPTVVTVAAAATSTWSAYSDPWTSTASFDNGSWENWRDGDSNGSPRGGNNGNNGGRWGGRGGAGGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWD9</accession>
    <name>A0A1C1CWD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_09458</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWD9"/>
    <dbReference type="STRING" id="86049.A0A1C1CWD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09458"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04120"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07199">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="614"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="11">
        <location>
            <begin position="683"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="8">
        <location>
            <begin position="687"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="8">
        <location>
            <begin position="719"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="8">
        <location>
            <begin position="880"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="721"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT52770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1191" mass="134323" checksum="B8C13316A30BFCC5" modified="2016-11-02" version="1">MAEPTEEEEHRHHQKDEETTWFALDRDASGEPVLAEYRRYAAVMMQTSELGSKTRYPSLVSFVGQTGAGKSTLINLLIDLKSDPRMANDDPAKMAPVIGRSSCTLPTSADVHLYISPETRFTKRPILYADCEGFEGGERSPIAITALSPETKDPSSSGNGSRRPDVLRKMSQGTQRLLKWASHNSQSYEQTSKRAYAVSEMYPRIFYAFSDIIVFVLDNPNTLEVVVERLLEWADANYSRSINQPTKPHAIVALNKSNPKTPEDQWNTVNATAHLLTTASAKIDENKTFVRYAKMRKKASLSRIDNMHDLLRCYYSTVHVVRIPEKSRYQKLDQQRRQLLQVIEDCCTIAFKDKQEREMLTDVDDFGLYLSLAFDHFSETLDKPFDFVEASLKRNPLSASFADNVLAFARRMAVHKNCEGQIVELFAYLTPFVASCILLESARKKRIGRPEDWFGDLEDDEPVNGDKRRPRRSASLPKNPVHDTYRDMCRKAISKYFHNDVQCNYAIYDPFALKKRPCELRYLRHGHSHRAKTKLRTIDTPGNFELSFEIDQITAWEEDILERLVDMHKDSRRTLTFETRQAALQAHSKLLQSIYRGGYTTSDKAAEFQLNSICVACLCNPPQHQLGCGHILCTDCVKDFGQQDGRSVKILTCPLHDNSQKNIPTGITTHVELAPAFSGLRVLTLDGGGIRGIVELAVLKAIEACLGVPLQKFFDLVVGTSTGGIIALGFGHEMWSVDYCTQQFQKLVQPAFSKRKGQDVHVIREVQLFVKHSKYETTPLESQLKEAFGDRTLFPKHRSEDRLKTAVIAVSSSGSKAWVLSNYNTHPGRGRGPPYQRYRPNRPRDEILTWEAARSTSAAPGFFKPFSPHRPGSKLEEWIDGAVLHNNPVQIAIEEARRLAEMEQLNGEPDVVLSIGTGLSKRVRHLGDIPSEEIHLGAPKARTTGWIRSLFTMVSYQIKLNTDADRRWASVLDTERHISGQLYRINPDLQMDPPELDAVDKVEELAKLLPRLLVEDGSLQGRIQEVACALVASSFFFEKDGPAVSTSSSSTEIHGWICCRLGHAKKRAGSDSVRGWMATPTQPITSLRGNKDDVRQLGKFVARSDRPEFIIYNEPKNENDVFLSIPVDEMMQQGEFSKQGAHLTVPGDDTVTTMALRLPGICGERAEFPITGFPRRLMKMDFNPSYRHDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWG9</accession>
    <name>A0A1C1CWG9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">O-acetylhomoserine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="12">2.5.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">cysD</name>
        <name evidence="16" type="ORF">CLCR_10095</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-acetyl-L-homoserine + hydrogen sulfide = L-homocysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:27822"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-acetyl-L-homoserine + methanethiol = L-methionine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10048"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-acetyl-L-homoserine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="12"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWG9"/>
    <dbReference type="STRING" id="86049.A0A1C1CWG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10095"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04143"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000083">
        <property type="entry name" value="O-acetylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="428"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT52795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="461" mass="49964" checksum="35F9F79728A0C9BE" modified="2016-11-02" version="1">MSSDDWVQKFETLQVHAGQAPDPNTKSRAVPIYQSTSFTFNDSAHGARLFGLKEFGNIYSRIMNPTVDVLEKRVAALEGGMAAVAASSGQSAQFMTIAALAHAGDNIVSTSNLYGGTYNQFKVMFPRLGIHTKFLTSEKPEDFEAAIDDKTKAVYVETIGNPRYNVPDFEAIAKVCEAKGVPLVVDNTFGAGGYYAQPIKHGAHILVHSTTKWIGGHGTSIGGIIVDSGKFDWAKHAKRFPQFNEPAPGYHGLKFHDTFGPLAFIIRVRVEILRDLGSCMSPFNAQQFILGLETLSLRCERIAENALKLAKWLEGHKNVAWVSYPGLESHPHHQLAKRYLPRGFGGVLSFGIKGGADAGSQVVDGFKLISNLANVGDAKTLAIHPWTTTHEQLTEQERIDSGVTPDMIRISVGIEHIDDIIHDFEQSFAASEAAQPDAEGNKDNATAGKEPSTEGSLSGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWJ2</accession>
    <name>A0A1C1CWJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Prostaglandin F synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_10662</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWJ2"/>
    <dbReference type="STRING" id="86049.A0A1C1CWJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10662"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04145"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="280" mass="31259" checksum="0C7D0024071C2548" modified="2016-11-02" version="1">MADLSLTSTFQLNNGNAMPILAFGTASKNDSKQEVLTALRHSYTHIDTAHIYGTEKDVGEAIRASGIPRSKLFIASKLWDPDFTRDGALQGVKQSLDAMQLDYLDLFLLHNPRGGAGRRRDAWLGLQDAVQAGLVRSIGVSNWSIKHLEQLAQGEGVKIVPACNQIEFHPWNQQAEIVKYCKGKGIQITAFSALAQGKRMDDKLINSLAAKYGKSPSQVILRWMVQRQIVPITKSSKEERVKQTTEIFGWELDPKDCEDIDKLDEGMKARIGDWDPDEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX11</accession>
    <name>A0A1C1CX11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative caib baif family enzyme protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX11"/>
    <dbReference type="STRING" id="86049.A0A1C1CX11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09806"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04384"/>
    <dbReference type="eggNOG" id="ENOG502QUIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025496">
        <property type="entry name" value="DUF4387"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14330">
        <property type="entry name" value="DUF4387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="36"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="246"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4387" evidence="2">
        <location>
            <begin position="511"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="614" mass="67179" checksum="C5F0E8F2C7402255" modified="2016-11-02" version="1">MSPGKTKDELRILTPVGQFGQGWNSGVFWDAVESGVDAIIADAGSTDSGPGRLALGKTAASMQGYRRDYGELVKACHTHGVRCLIGSAGGSGSNAFVDMSTQIIKEIIAEKGYRPMKVISIYAEIPKDIVRQKFKDNLISPCGRSVPELVEDDIDSATRIVAQMGLEPYVKAMDENPDFDIIIGGRSYDPAPYAAFCLHHGFQDTALNYAMGKIMECGAQCAIPKSRECLAIIRHDSFDLVPLQPGAWCTPVSVAAHLLYEKSRPDVLQGPGGELHLRDMNYEQVGDRIVRVRGAKFIHQPEGEYTVKMEAARVNGYQSSFVGAFRDPILISQLDTWIPAVKETVKSRMSSDYPYDTKVITYGINGVMGALEPDKSLPKEVCIVVQCRAPTQEQANEVANRTKMGFTHSPYPGQLATAGNFAWPITPCETAIGPVPEFCIYHLMHKADPVGLFPFKVEEFQGPNTFVHTRGEKVAVKADVAVANSIALLAKTGQPKKYYLRPEPATGTCYLGDVASVVRSKIAGPYEVTFDIMFPTEEIYKKVKGADVLSPATVAKLYNIPESDVVAALWWDPAQAFKATIPRYRASAGFEETDTHGSQQHAPLLYLSLPWGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX94</accession>
    <name>A0A1C1CX94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gap1</name>
        <name evidence="3" type="ORF">CLCR_09638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX94"/>
    <dbReference type="STRING" id="86049.A0A1C1CX94"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09638"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04409"/>
    <dbReference type="eggNOG" id="KOG2128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="182"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="775" mass="88795" checksum="402845CE8E7C251B" modified="2016-11-02" version="1">MLQPASRGSTSTNSSFEPVSRTNTFSSHDGARSLRQSKRVSMTALYASMSAKDKDLEISDDLARAQRALRDLKAKISNQSKKNFVLEKDVRYLDSRIALLIQNRMALEEQNEVASHLDEAAELQEGSFPNDDKTQKYGNLCFMLQSEPRHIAHLCRLVTMAEIDSLLQTVMFTIYGNQYESREEHLLLTMFQSVLTHQFETTPEYSSLLRQNTPVSRMMTTYTRRGPGQSFLKEVLADKINSLTELSDVDLEINPLKVYEAMVKQIEEDTGVLPDDLPRSVTAEFAAENAQVQAIIAPRLKMLTEIAEGFLSAIIESLEDTPYGIRWICKQIRNLSRRKYPDAQDQAICTLIGGFFFLRFINPAIVTPKSYMLIERVPDEKPKRTLTYIAKMLQNLANKPSYAKEPYMAKLQPFIQRNKDRCNKFMLDLCEVQDFYESLEMDNYVALSKRDLELQISLNEVYATHALLEKHSAELAKDPSSHLAILLQELGPAPPQLPRRENRAINLPLYSKWETSFDDLTHALDITQEEIFFMEAKSTFVQIMRSLPQNAVVMRRPLHLDRVAEAAGTLKNDAVMVRKGIRCMELLTQLSELGAVDRADDYAILRDEVEQELAHLGSLKEKVLEETAKLEDVYKTIRDHNAYLLSQLDTYKNYLHNVRSQSEGTRRGKTEKVRELGPYKFTHAQLEKDGVITRSNVPENRRGNIFFMFRSPLAGTFVISLHYKGRARGLLELDLKLDDLLEMQKDGQDDLDLEYVQFDVSKVLTLLNKRFARKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXI0</accession>
    <name>A0A1C1CXI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">CAT2</name>
        <name evidence="21" type="ORF">CLCR_09818</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXI0"/>
    <dbReference type="STRING" id="86049.A0A1C1CXI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09818"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00253"/>
    <dbReference type="eggNOG" id="KOG3717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="20">
        <location>
            <begin position="40"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OCT53287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="615" mass="70004" checksum="E65553B7801F028C" modified="2016-11-02" version="1">MAPTNKRKASNRPQFWVTEEYREDNSKGAMLRFEDSLPRLPVPSLEETSARYLKSLHPLLSKEEFAASEKAVAAFNQPGSIGQKLQERLIRKAQDPSVKNWIIDWWNEAAYLGYKDPVVPYVSYFYSFRDDRRRRNPAKRAAAITTAALEFKRQVDDKSLEPEYMRKKPMAMSSYQYMFNTSRVAAEPVDYPIQYPAEGHEHIIVMRNNQFWKLQTHVAGKQLNTSELELQFKKIYQNAQLADPIGALTSLPRDQGAKARGNLLAASDLNAQVLEEIESSSFFVCLDSTMPVTLEERARVYWHGDGSNRWYDKPIQFIVNDNGTAGFMGEHSMMDGTPTHRLCDTVNAYIVHNKLDFDNPSVRSDLPDPVALKFETNAAVLDDLASAQAQFRQVIASHDLRVQAYQGYGKGMIKKFKCSPDAYVQMVIQLAYHKMYGKNRPTYESAATRKYQQGRTETTRTVSDESVAFCNAMADPSVSREECERLFRAAVQAHVKYTADASDGYGVDRHLFGLKKLLQEGEETPEIFTDPAYTYSSTWYISSSQLSSEYFNGYGWSQVIDQGWGIAYMINENSIQFNIVSKKLGCERMSFYLNEAASDVRDMLLPSLEPPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY40</accession>
    <name>A0A1C1CY40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat domain 5B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_09957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY40"/>
    <dbReference type="STRING" id="86049.A0A1C1CY40"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09957"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00420"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000510">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="182"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="5">
        <location>
            <begin position="184"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="232"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="364"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="463"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT53453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="578" mass="63714" checksum="62C9961A900BF08E" modified="2016-11-02" version="1">MDSDRYPPPKRRRTSSEDSSSSRNSAAHPRTHPPSSSRHQESTRPARDMNRGRGYSTSRSRSPENSRNDTPGRDRSRSRSRSRSPRRRRLSRSPTGSSTYDSAPEHQQRSRRSRSRSQSQSHSRSRSRSRSRSRLRSDTYSPRQSRSPSPSHSHSRRPSASLLPPPSLKPKALKFTPLVTLPRAHARGITCLKFSPDMVLLATSSADNTINIYSVPANPTPESSHFKHIRTLRAHLAGVNAIAWSPVGPPYTLASASDDKSILLWSPLGSDFPIAPSPLTGHSNYVYSLCFSPKGNMLVTGSFDEAVFLWDVRSGRVMRSLPAHSDPVGGVDFLRDGTMVASCAGDGLIRIWDASTGQCLRTLVDEDRKAVTTVKFSPNGKFLVAWTLDNCVRLWNYVEGRCVKTYQGHVNAQYSLGGTVGSYTHVYGGGGDRRLEAFVASGSEDGDIVAWDVTSKDILWREKAAHRDVVLGIDFGRTKEGKGLLVSGGKDRDVKIWLLEGDEAEREFFSSENQGQHQGGGVGVDVDVDVDMDMDMDMDMDCVVEGPTVYGNATGPLKREADENAMLIDRPTPEVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYA4</accession>
    <name>A0A1C1CYA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-apo-4'-carotenal oxygenase</fullName>
            <ecNumber evidence="4">1.2.1.82</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Beta-apo-4'-carotenal dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Aldh3b1</name>
        <name evidence="8" type="ORF">CLCR_09686</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.82" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYA4"/>
    <dbReference type="STRING" id="86049.A0A1C1CYA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09686"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00450"/>
    <dbReference type="eggNOG" id="KOG2456">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07135">
        <property type="entry name" value="ALDH_F14-YMR110C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="106"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00082640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="635" mass="69680" checksum="D02CEFB4DA6A2B49" modified="2016-11-02" version="1">MASNDGIFACRLSNVSMSTLLHAGDPESHKAQPIFYRPSTSTDAFVSRHTILPEAESCIHQLGIVDDDIRLIARGLSRGDQASDPSQTPPRALLLAGDTNCLLRAAVMASIEYTSPEEFESAYKTLQSTFASNRTKSIKWRKWQLKQLWWLLEQNLDKIVDALHTELNRHAFETLTMEVRGIKGDIVDMLEHIDEWSQGEKPDAGFVFGTLGKAWLRKEPLGVTLIIAAWNFPLYTLLSPMVAAIAAGNCIFLKPSELAPATQALLVDLVPKYLDQSAIRLVTGGPAEVGRMLESKFNHIFYTGGGKVGRVIATAAAKHLTPVVLELGGQAPVIVTKSADIELAAKRIAHAKLTNSGQVCLNGNHIFADAAVHDRLLERLQFWFDKFLETGSEQFATIINERHFDRIAGLLKSSAGVVVYGGDLDRERKYIKPTIVRDIMTDDSLMSEELFAPIAPVIVADVDRAIRIIRSMPPPLGLYIFSKDQAEIDHILDHTSSGGVTINDLMIHAGVPHAPFGGVGESGYGSYHGKYGFDAFSHTRTVVAPPTWLEAVMSFRYAPFDMKKAKFADIKSSLVGKPGETMEEQKVGKKMAVSTILRNAVLAVAVLAAADSATGGKLLFVHTMRDVVDKVWRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYT7</accession>
    <name>A0A1C1CYT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Coiled-coil domain-containing protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_10610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYT7"/>
    <dbReference type="STRING" id="86049.A0A1C1CYT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10610"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00522"/>
    <dbReference type="eggNOG" id="ENOG502S9DW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="77607at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="301" mass="33124" checksum="CA2845CBFDD0246D" modified="2016-11-02" version="1">MTDVRALLAAERQSRRITHPHLSYTKSGVLLCNICNLNVKSEALWEGHLKSANHRKNVAAQASRQASIDSTSAKGVKRKIEDVDEVLLERDELESEARKKPKSRPESTLVEDEDGEQAGPVLPEEEAPGQQVEPAPAPAPMPVTDKAAQTNGPSTPTPAVNEDEWAAFEREVAPLAADKPKPDYSSATITAAPLTADQIKAQQDEDRRRRLETEAEDEKEDELGKLAEEFDVMEEMEDRVRKLRAKRDALRSAAKPGDDTGQVTDGASVATLVVSAATNGVEEDEEDEEDEEDEDEDDWYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ83</accession>
    <name>A0A1C1CZ83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative RNA binding protein Jsn1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_09494</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ83"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ83"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09494"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00616"/>
    <dbReference type="eggNOG" id="KOG4574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000167">
        <property type="entry name" value="RNA binding protein Jsn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="423"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="9">
        <location>
            <begin position="575"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="6">
        <location>
            <begin position="633"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="6">
        <location>
            <begin position="669"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="6">
        <location>
            <begin position="706"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="504"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="947"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT53670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1127" mass="122255" checksum="2C51C88A55BABB58" modified="2016-11-02" version="1">MADPPTVPTSKSPFGSSKSSSGLAGLSSARVGAGSPLHDQASRLFPKRTRELQSQAGLAPNIWGPPTSGTSTPLFEIPESPNQDGFPDLVPLTETGINSPARRGRAGTLPSRISPVGTVNGVNVLTSKTSRPTPSTSPFRPGSTSAAETAFYSTSSNQANPATSALLSRLRAGSMPQRASLLGNSSAFTSNTFSTGWGTRTRAATLTSISSAEDPTSPQPSGYFKDGMSDSGVRTLDYLGLAEPPHQSRSDALRQGANESGRSHDTNLPDVLGFGMRNSSRFRSFSVNTQSKYQTESQEGNTSFPLFQSGTLTPSAAAALEAEYEMVQEKVRLHNQAVQAFAVNASAARPRARTAGLVETPQRTSLRNFVQQPADSVDMGFDMQASDMLEPSSLTDSLQHLTIGENMPLAFEGLDDPDVQISRSLWIGSIPNSTTMSSLDAIFSRYGAIESTRVLTHKNCGFVNFESVEHAVRARQLLNGKEIFPGAGPVRIGFAKAPNASVSITPVQNATPPPGSNGNAEAGPSQPHDTSGSPTGSLHAQGTLNLPAADRLTELQPDILQIVLDFGGPQSDLAGISANIESAISFNRFEKEIPPIPEPSATRMYDAPRLRDIRKRIDNGACGLQEIEQIAIDMLPEIAELSSDYLGNTVVQKLFEYCSEQTKEQMLTRIAPHLAEIGVHKNGTWAAQKIIEVSKTETQIQLIVDTLRPYTVPLFLDQYGNYVLQCCLRFGPPYNDFIFETMLSQLWEIAQGRFGARAMRACLEAHHATKSQQRLMAAAIALHSVQLAQNANGALLLTWLLDTCTFPHRRSVLAPRLIPHLVQLCTHKVAYLTVLKVINQRNEPEARDMVLKALFFSPNDTVLEQILCDQTSGVTLIFKILTTPFLDENMRPDVVQNVSRVLSKIKAQPNQGYKRIMDEVGLSSRPTQPAMQQFPAHGHPANDRARSMAQTQQPQMPAHGLPQQTFPQRQYSGTFVPSVNGNTFDNGIGPIRTGSADSFGFPPYNMNGFQAQQQYSQLPYQQMTPQSQYQGFPSTAPQRNNSGYMPNGYNGYATPPSAVDPFRPMANPSSSPLSFSAQMSPVIGSSGFPPQNFLQNMPSNMYNYPQQQYFVSSPMQTVYSGGRGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZN3</accession>
    <name>A0A1C1CZN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_10329</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZN3"/>
    <dbReference type="STRING" id="86049.A0A1C1CZN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10329"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00756"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF29">
        <property type="entry name" value="BETA-GLUCOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="10">
        <location>
            <begin position="149"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT53830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="324" mass="34751" checksum="FDAC826D2F52FE5A" modified="2016-11-02" version="1">MWLPEAAVAALAVLPYLPRTHASTSRPYKSLSKDAKMLGLAPALLLGVNATVQVSEYSQAVLKPVESIDAIYKRQAAQPFNNDYTGPYYESPPKYPSPWGSGAGDWATAYEKARSFVSGLTLMEKVNLTTGTGWESDKCVGNTGAIPRIGFPSLCMQDGPLGIRFADYVTAFPAGINVAATWSRELARARGEAMGAENRDKGVDTLLGPVCGPLGRHPEGGRNWEGFSPDPYLTGALIAPTIQGIQSQGVMACTKHFIANEQEHFRQVGESIGYGYNITATLSSNIDDKTMHELYLWPFADAVRAGTASGQCSLDIGLRILTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZT8</accession>
    <name>A0A1C1CZT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10290"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00962"/>
    <dbReference type="eggNOG" id="ENOG502S1B0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4121291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="421" mass="46254" checksum="5602B296A77323E4" modified="2016-11-02" version="1">MARLPAFPIYEDDILIATKTIIPPQGNAPPSPPTSGLPDFTGDPDVMYSTSGHYFQSATTVSPEREFDLGDEFGADCASQRLDSKPYPRELAVKEEPTHVSDIENRRPSKYDTKPPPSTPSQVPMMATPTSSSPITVRRNPKPDRSEATPARGKFTASKSGQLAAKSQPASSSRRRNLQTAPNLGPEVEEDPATDHSDTEDYESADEKGDHMPTERNLRKRTLQQTNPFKFDKHKHIAQKTGQQTSTKKIENKVQQEIEGSQKEPAKKKARVSSGNSTKNKTKASASHSQSASKARRSSSILSTAVSPEANSEHGFDPAKTILRVRLDGFAGAAAPITLVQCDGLDKLMDFIIDSWGWRFNGDQFSYAVAAFPWLSDQSNILLRPGMEASFQLMMTEIERAPVWTDGHCTSCEVDVTVYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D165</accession>
    <name>A0A1C1D165_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D165"/>
    <dbReference type="STRING" id="86049.A0A1C1D165"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00897"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01676"/>
    <dbReference type="eggNOG" id="ENOG502SRIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="64"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="348" mass="39677" checksum="DF501F6465D4CE85" modified="2016-11-02" version="1">MWLPNPTRDRTLPNRSRRNDLRPAFQPRSPPNLSAQVSIASQGACSVAKVAKPHLSRPARPFRFFDLPGEIRNRIYDLVVPEARVIVSGTHPQKELQQLKKREPKRKHQTPRYHLRGTFAGGSTEASLLFSCRQMNREAVQYVYARTTFCFTSFVVLRKFLSAVPEAARSSIVSLEITHIGYGEPPLLADREWKLRHDAKWSAVLHQVKQQTALRRLVIDITNFDWPIQLEAREPWAKPLLELGADGLDHVDVTLEHDGFPQDRCTAAAKELENRMMTREGRKQKRQEEKRKAADEKKRLEETTRKATKVLTIKLPSSAAQISGPVKKVVRSKGLEQYAIAQPPIAFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1K2</accession>
    <name>A0A1C1D1K2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin associated protein Wsp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_02820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1K2"/>
    <dbReference type="STRING" id="86049.A0A1C1D1K2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02820"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04724"/>
    <dbReference type="eggNOG" id="KOG3671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8963340at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01205">
        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000281">
        <property type="entry name" value="Actin associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033927">
        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="3">
        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="4">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT54616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="640" mass="66193" checksum="C736D86E6216ECF2" modified="2016-11-02" version="1">MPSVLTDADKETVKRTVPKASNKIQAVAVARLYVAYPDRSRWTYSGLQGAAVLSNDLVGNTFWIKLVDVSPANRGVIWDQEIYDTFQYNQDRTFFHSFELEQCLAGLSFVDEKEARQFKKKMDEREKNASKNTKAQPFASAAGGGQVFVPGSTHKHHSRVGNFFGRHRQSSASLQPQPIAPQPIYSPGPAPASRPQSAGGIDLADPSWRPILDELLQMGITEDQIAQNADFIKAYVQQKQAEEMANGIASALPNVAETRSRAPPPPPPSAPPARISPENTGSTTSGRRGPPPAPPPSRRPVGGREASPPPPPRSVSPPARTPSPPATPQPRFRAPPPIADAGKFAVKEGPALHPSGRSRASSGSLANPGPPPPPRPPKTPIEEEQPQGGLFRVPPPFTGDRKSSAPPPPPSRGPVPPPPPSRGTPTISAGPPPPLPPKAGQTPSHSALFVPPPPPPPPPARNNAPPLPPPNTRAVPPPPSGAGPPPPPPPPMPSLGGPPPPPPMPSFGGPPPPPPPMPSSGGAPPPPPPPPPPNSSGPAPPPLPSGGGDGRDSLLAAIRGSGGKAGGGLRKVKDSEKRDRSSALVPGTENSAPAPPGGTGSPATPAGDQGGLAGALAAALSQRKKKVSGSDDEKDDDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1V6</accession>
    <name>A0A1C1D1V6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxisomal biogenesis factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PEX3</name>
        <name evidence="2" type="ORF">CLCR_02885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1V6"/>
    <dbReference type="STRING" id="86049.A0A1C1D1V6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02885"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04812"/>
    <dbReference type="eggNOG" id="KOG4444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="536" mass="58564" checksum="625975023B13417A" modified="2016-11-02" version="1">MLSATRRWLRRHRTGIAIGAGIAGAGYLAAQYVIGKVNEARERMQMDRIAKENIRRRFEQNQTDCTITVLALLPTLTDNVVEDLPVEQLTHELQQKKAERLARAAGEGKSEASSMHDGDTASMSSFQTGSFMHTSQFPLNGSQSTGPRRTKAQLWNELKVTSLTRAFTLIYSLSLLTILTRIQLNLLGRLNYLSSVISLAQPPPPGRANSISLEDHDDGSAGAGFGNDFETNRRYLTFSWFLLHKGYAQILAKVRQAVEEVFGGISPSEGITAARLSDLVLEVRKKVEGSSEQERYATRWLPYVLPPKEEEEAVLVESGVITPPATSPGSESLHQEHDESRHGSIHIDTSTGPLRQLLDETADLIDSPTFTRIHTLLLGSMFSHLIDARVIEQSYPQQRPHSPSSSISSAPHPRIQELDSAVTVVPGEPRVKLANILAVITRQAHAIGNGNNPPNEYVSTAEAEVKELEAFAAVIYASNIDHSLDVGQPNHDEGGLKASDGIGVSDVGAEPVNELIESKLESAWTKVTGSTSFSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1W8</accession>
    <name>A0A1C1D1W8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mannosyl phosphorylinositol ceramide synthase CSH1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CSH1</name>
        <name evidence="8" type="ORF">CLCR_03021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1W8"/>
    <dbReference type="STRING" id="86049.A0A1C1D1W8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03021"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04851"/>
    <dbReference type="eggNOG" id="ENOG502QS3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000001">
        <property type="entry name" value="MIPC synthase subunit (SurA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="349" mass="40394" checksum="3E30C4FFDE6EF4B5" modified="2016-11-02" version="1">MRRSLLIFLLFAVVVLTFLLHSVSTLLALLIEDASRDAIHRSELPAPNSTLLETRPQLIPKIIHQTYINESIPAHWVPAQQSCIDLHPDYEYKLWTDEKSHDFIAQEYPWFLSTFVGYRHNIQRADAIRYFVLAHYGGVYLDLDDGCKRRLDPLLSYNAFVRRTVPTGISNDVMGAIPQHPFFLRVMESLPGANRSWILPYITIMASTGPLFLSVIWKKWMGEHAHLNPDTWVGRVRVLMPDEYNQHAWSFFETYKGSSWHGKDARLIFWMGKNWLLLTVLGFVLVLTVGFLVWFVYSRLLMWSARRRGSPRMAALRFTGGAKMPLWRMWAGGLGINKQTYEMVAQHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D244</accession>
    <name>A0A1C1D244_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pantothenate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_02815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D244"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02815"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04874"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="520" mass="57768" checksum="78E505A3B19F8F00" modified="2016-11-02" version="1">MAEKPLSVSHVEKSDEALSHSSDRNDEETSTPTGQDWTPEEERALVYVCPAPHATHAPKTDKTASKKLDWRVFPMLCVVFGLSLLDRTNISAAYIAGMAVDLELTVGARYSIALLVFFIGQYLSPRFEKRECAVHADVRHQGYAIFELPSNLVIRRLGAQIWLGFLITAWGLCVLGMGFVHSWEALTMLKVFPGGVFIIGSWYRQFETARRVSLFYMASLLSSGFGPIFAYALSLIRVGDGMYRSGWRWIFIIEGIATVVAGLISPIFLVEFPERVKWLNPRQKYIAQARLQADQAAKAYVHPTLKESMKMLLDWKLIVYSIQYFVAASSVYSIAYFQPIILREGMGFSYALAQILGSPPYMFAIIASLAMAWVSDHYRVRWPVLVFQSGIGIVGLLVILYPKPPGVRYFGLFLAVFGCQANVPGTLAYGQSQTADVRKKGVVAAVMISVGAAGGITGSTIFRSQDAPQYLPGMWSTIAMQVLYSAVTFGMSMYLKRQNRLADEGKRPALEGVEGFRYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D254</accession>
    <name>A0A1C1D254_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_03130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D254"/>
    <dbReference type="STRING" id="86049.A0A1C1D254"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03130"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04961"/>
    <dbReference type="eggNOG" id="ENOG502S287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF120">
        <property type="entry name" value="HIGH-AFFINITY COPPER TRANSPORTER CTRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT54869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="185" mass="20315" checksum="0E88260D195EEA4D" modified="2016-11-02" version="1">MDMSSHDSDSMDMGSMSMPMVFTTSHHTPLYGTGWTPSTGGAYAGTCIFLVFLAILLRLLFAGKSVLEQRWAIAARNRRYVRVQGRTTEAGRIDQDPDVKTGSLITVNGVEEHVKVVQARTQSTPFRLSVDVPRAVLTTLIAALSYLLMLAVMSYNVGYFLSVLLGVFLGELAVGRYAQNDDHVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2L4</accession>
    <name>A0A1C1D2L4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD dependent oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2L4"/>
    <dbReference type="STRING" id="86049.A0A1C1D2L4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02917"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05142"/>
    <dbReference type="eggNOG" id="ENOG502S0HA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF284">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT55049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="473" mass="51480" checksum="49ACBD78EE2396D5" modified="2016-11-02" version="1">MDQRRSIPPGLPRDNPIQSYWQDPPDEIADCRTSPDLPDEADIVIVGAGVSGASIAYNLLSSNPRLNIVLLEARQAASGASGRNGGHTKTATYRSFHENVKSVGTSDAIKITNLEYNTMVNVHAFAREHSIPCDSVRCQTIDVFYDSAQFQAAKASVALMEKSMGVDKAPKHILHGVEETAEKYLAPGSVGSLEYESGSLSAYRFTIGMLKLALEKGLNLQCNTPANSLSRDENGHWTVSTPRGSITSKKLVLATNGYTAHLYPRLQGVIVPLRGVVTAQRPGQSMPQHGLETTYSFVYKEGFEYMISRPPGSQFEGDIVIGGGMHVAKDDGMNEYGNTDDTTFDESSAGYLLECTRRYFGPKNWGRDHPDGHNRRTWSGVMGFSADGYPFIGPVPGEEGLYLSASFQGHGMVLCFLCAKAATTMIEGKDGDALSSWFPDCYRVTRERMGKKFEGRIKASGAPEPQAVENGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2R4</accession>
    <name>A0A1C1D2R4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pfs, NB-ARC and Ankyrin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_02740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2R4"/>
    <dbReference type="STRING" id="86049.A0A1C1D2R4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02740"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05168"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF13">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="4">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="315"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="863"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT55076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="963" mass="108850" checksum="AF1B9CAAE2B39DEB" modified="2016-11-02" version="1">MHLLEIDSQGEIRLTEDLHDGIPPYAILSHLWGDDKDEVKFDDLKHESWKRKAGYTKILFCARQVKKDNLKYFWVDTCCINQANFTAYSEAINSMFRWYRDAAKCYVYLPDVSVREGDENHIKRIWKLAFRRSRWFTRGWTLQELLAPASVEFFSQEEERLGNKETLEQQIHEVTGIPIAALRGASLSKYSVEERLRWAANRNTTKKEDKAYCLLGIFDVFMPLIYGEGGKNALNRLRMEIDQSRSKPFTHTPAATSSPVQCDSLPSSTEGNVVHGPRRGSTTAHEQGKYQRLLRSLTFERMDSRLLNITNALPQTCRWIFDEEKFKTWITRNEVEDNHGFLWIKGKPGSGKSTIMKEALKMVKREQPRDIIISYFFNARAPGILEKSSVGMYRTLVHQILQARPQSRGLFSQMFAMKDREGSVDDWTPTELQGFLTDVVESLGDRTLDVFIDALDEGDENDVRQLVAFLEELSHRAVACSTSLRICLSSRHYPHISIRKGLHLVMERQDGQRDDIDRYVRLRLNGDESHGTNRLREQVCQKSSRVFLWVVLVIPMLNELYDRGLVAAMEARLKELPDTLDALFAEILARNAEGIDSSVLLLQWVLFSMRPLSPVELYHGIQSGLASSPIEGATSMTKETMDRYLLNCSRGLIEVTRTEPPVVQFVHEAVRDFLIGANGLKKVDTRLAGNVKGISHEQLHTACLRYFDQCLPLNPDYRGEFIPKWAQPLDLQQKFPFSKYASTCMFPHADVAESRGIPHRAFLRRFQSKDSHELLKWIRFRNSFQRLEVYEYTLDVHLLYILAEKNLANLANVLIDDGVDVNARGGSYGNALQAACAKYREQMAKLLVESGANINAQGGPYGNALQAAAARGHERLAQLLIEKGADVNAQGGPYGNALQAAAVCGHELLAQLLIESGAEVNAQGGDYGSALQAAAARGHKQLAQLLIEKGAVLRPTGNGRQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C665</accession>
    <name>A0A1C1C665_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT43990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C665"/>
    <dbReference type="STRING" id="86049.A0A1C1C665"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00098"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02055"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="63"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="147"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT43990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="63361" checksum="6DDF216BC04752FB" modified="2016-11-02" version="1">MARLGSPPLRDQILRETRGSQFNCNAPGAHLTGNSSCACSLSSALPYFPLRALLSCLGEKQDKMLEVYCDPCTVNSHKVLAGLDILGYPYHFNKVDYFTSEHKSPEFLKINPHGTVPAAVDGDLKITESNAILQYAADDSGLMYPRDAKQRCTINRWLLWETSVWFPSCYVYLVEFVVKPLLQAEPDQSVIDGEAPKWHKHAAILDEQLSKTKWLTGDNLTIADIAVAAPMHLHAAQRLPLDKYPNLNRWLTEQIEKIPEWQKTQEAVNKALQPGKAASTNGTAGTVRANFVYTKDVEKRTELYFYDTDAAQDIHEPGDDPHEMEVTDGWYRAGSFSVDKEGFSLHHFKTEFADWENEDVVREQFYPEIVEFLKSSTGAKRVLVFDHTIRTKKNEAKKLTQETNTSQRAPVMLVHCDYTAESGPLRVRQLLKDEAEDLLSRRVAFFNVWKPLNTVEERPLAMCDVTSCDENDFFKLYLRYRDRVGENYLMRYSPNHKWWYFPRMTPEQVITLKTYESESDGRARFVGHSAFEDPTSSPDAPPRESIEIRTMAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6T4</accession>
    <name>A0A1C1C6T4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein transport protein BOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BOS1</name>
        <name evidence="15" type="ORF">CLCR_00657</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the BOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6T4"/>
    <dbReference type="STRING" id="86049.A0A1C1C6T4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00657"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01103"/>
    <dbReference type="eggNOG" id="KOG3251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000054">
        <property type="entry name" value="Protein transport protein BOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="136"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT44177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="272" mass="30757" checksum="2F5A88A266C11F50" modified="2016-11-02" version="1">MPRSKAQLRLYLALGSRRQQQNHHLSSPSNVVFNQALKQSTAIRKDLEAFAQAPATASPALQGQLSTTLTSLSRTLEDYQNLSRNELNEEKKEKAAERLKNFRADLASYRTQFDQLKKERDGAVAANNRNELLGRRPHHAATPENPYAHASSTQSAFAPAHRNTQDGLSFGAGSSNYTREEHALREQNFFDSANSQLDEFLDRGRAVLGDLAHQRDILKGTQRKLYSVANTLGVSGDTIRMVERRAKQDKWIFWAGVIIFFSFCFLVIYFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C719</accession>
    <name>A0A1C1C719_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular serine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C719"/>
    <dbReference type="STRING" id="86049.A0A1C1C719"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00634"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01174"/>
    <dbReference type="eggNOG" id="ENOG502S0EC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF8">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_6G00670)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650615" evidence="3">
        <location>
            <begin position="18"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="450" mass="46518" checksum="4756EF93856FE3EB" modified="2016-11-02" version="1">MRRTLVLFLGLAAVGFAQDPTAPPTDSATPTATDSVTPAPSPTDASSSADGTDLSNSTSTTSTSQEPITHTVGVALGGHTFVPDVTLARVGDTILFQFYPTNHSVIRAEYGFPCIPYEDTGVDKLGFFSGFYPVDAILSEPPEWSFVVNDTNPIFFYCGAPGSCINYQMVGVINPNATTSLQHQKDLASQAQFMLLPGEPWPEESEDPFTTTTSTPSPTATGSGSESAASDSVASSSDHGHSSLSSGAIAGIAIGAAAVALAAAVALYLCGRQSRGRGAKHVDDRPSTGHATQVSFNPAASHMSYMTDPAKHMSVHSSVVGLGPSPALPGYVPPHDPAMSPGFHPAYMPVSDSLGPAHTGPGSDIASPHSPSPSQMYSVPAYPGGMPPSMHSTPHQSVMYTAVPPPHVHEMAASEPLPGQPQSQTPQGAGIMGFIRRSSVSKTGGVERYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7F1</accession>
    <name>A0A1C1C7F1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_05917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7F1"/>
    <dbReference type="STRING" id="86049.A0A1C1C7F1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05917"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07093"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9993796at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF215">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="430" mass="46488" checksum="561F898C78B54574" modified="2016-11-02" version="1">MPPRQLEVGIVGAGIAGLGAAIALAHAGHSVSVYEKSQFRNETGAAIVIGPNGSRILSKWGFDYDGAGALDFSEMRRLRGDTLALDSEEFFTDIKTKYGDRWLLFHRADLHAGLKALATTGAAGEDSSPGRPEIHLGVEVTDVDVERGIITFATGETVTRDLVVIADGAHSELVAKVLGRPCPVNRSPMSMYRFLQPMARILAHPDAGPFYKDRAPGFTTFYKTEVGRPGLLINTYPCRGGDLLYVALVHPTKPAEKGLVGWDSPADVDNFLADAKDFHPAVQAVCDDATDIKVYTQMWRDPIERFAKGRAVLVGDAAHLMLPTHGQGASMALEDAMALQVLFTGVDSAAADPVASKLQVFDRLRVPRVSAVQTMSNKMMGPPDKMIAEIKRYYGGDIPGPKAKTFSNEYNDFFFLYDVENEAEKAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C840</accession>
    <name>A0A1C1C840_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vegetative cell wall protein gp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C840"/>
    <dbReference type="STRING" id="86049.A0A1C1C840"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06014"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07294"/>
    <dbReference type="eggNOG" id="ENOG502SK85">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5398854at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="42560" checksum="7834A53D87209C0D" modified="2016-11-02" version="1">MSFHYGVPPSHYTKYYGSNTSPYSSGEYVHYAPQYDTPKKHARKTSYTPSPRVGGWYSPAGSPPPYYDANVQYVPREEIYVSEARVKTRKQESYSTFPSSRYHTRSSSRKQNQPVYIYDEDAEYAGAQPTYVYREPKTKPNHARKPSTDTYFYYGQEQIVEEQPKRSRARRASTTSKPSPKPKSRPAAQATEQDAIRAGIPAGYSIKHWDPTELPIILLGSVFDANSLGKWIYDWTVFHHGASTPIADIAGELWLLLIKLAGKMKRAEECVGRIRNVEKQETVEDFIVSGKRLWEKFKALLKECEHYMLKAAKRDGTKTMGKKAGTEFVDSIFGRDRHLEHTEKIMNQIRLWNMRFDVNCEETLRRPSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C843</accession>
    <name>A0A1C1C843_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">betB</name>
        <name evidence="10" type="ORF">CLCR_05823</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Aromatic compound metabolism; naphthalene degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C843"/>
    <dbReference type="STRING" id="86049.A0A1C1C843"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05823"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07365"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07114">
        <property type="entry name" value="ALDH_DhaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000010">
        <property type="entry name" value="Gamma-aminobutyraldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT44695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="496" mass="53344" checksum="076FFD54262B9FA7" modified="2016-11-02" version="1">MTTIPHVSNWINGAHAAPAQQRIQVINPATETALATIDATPRETVDAILAQSVHTFRHGPWSQCDASTRFAVLSRAATLLRSRIPEFVDLETQQTGRPVREMRAQLARIPEWLEYFASLARTHEGRVPPFKGPVVNTLTRLPLGVVAQITPWNHPLLIATKKIAAALAAGNVVVVKPSEMAPLSVLRLGLLFQEAGLPDGALQVVCGHGCETGKFLCESPLLAKIDLTGGMATYRAIAPRAAEHMIPVTAELGGKAPVCVFPSLDVAQAVKAALFASFIASGQTCVTGSRLLVHADVYERFVDLLVSRVEALRVGDPTDGRTQIGAVISQAAVERCAAFVDRAAKEGGKVLCGGRPTKVDGKGFFFEPTVIETHAASDLSCNEVFGPVIALIRCESEEHIIEIANESSFALGASVWTNDFAQAHRVAEKIDAGIVWVNGHHLNDPSSPWGGFKESGMGKENGVEAYESYTKVKSTVFNYGVPPTWFDDEIENARYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8H3</accession>
    <name>A0A1C1C8H3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Dpm3</name>
        <name evidence="9" type="ORF">CLCR_06441</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8H3"/>
    <dbReference type="STRING" id="86049.A0A1C1C8H3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06441"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07496"/>
    <dbReference type="eggNOG" id="KOG4841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2014333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650666" description="Dolichol-phosphate mannosyltransferase subunit 3" evidence="8">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="100" mass="11060" checksum="96F38D63A7453DE9" modified="2016-11-02" version="1">MTRARQTISFALLVSSAYLLLALPLLTNDSPIPSILPTKLQVEIIPVLPLWAIVSLGAYLLGRLGLGVIRFNDTEEAYKELTAQLGAARKSLDNRKVRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8H4</accession>
    <name>A0A1C1C8H4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PEX12</name>
        <name evidence="18" type="ORF">CLCR_05850</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8H4"/>
    <dbReference type="STRING" id="86049.A0A1C1C8H4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05850"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07513"/>
    <dbReference type="eggNOG" id="KOG0826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="17">
        <location>
            <begin position="25"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="418"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT44843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="476" mass="53619" checksum="55A1A2AEA49C422E" modified="2016-11-02" version="1">MEYLNALQSPVDDHKPSLFELLSEQQLAALLPPTLRYLLAVATHRWPRYLLRILNNYDEVYGLLSLVVEKYYLQTFGGSFTENFYGLKREKVLSVRGGEVKRTQLAVPAEVRERLKLRGADIWKNLAVLVGIPYIKRKLDESYDIHIAPSAGLMMGGGGLGGVEGRRYLDRDALPPNATIKQRIMWYYKWFLRNVYPSLNAAYYFSILAFSLAYLFDGTKFSSPFLWMVGTRMRRMGAADYQAIDAARDAADKAATYVAGRPGQGLSGLMNPRTMYPRLLSSLRILLPTSIFALKFLEWWHASDFSRQLSRKAAEGLELPPPVVSGMELAKKLNVYQRAAQGKSANTGTKRTPPTSSITYLPIFTVPPPSSSDLCPICLHPISTAAACQTGYVFDYKCIFQWIEGTHERQEAFMRGEKMSEWEDDEDEADEEGKSHDESKTERKSREGSWESGKGRCAVTGRRVLGGTSGLRRVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9E9</accession>
    <name>A0A1C1C9E9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9E9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06398"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="151" mass="17163" checksum="AFA8633271A2B56E" modified="2016-11-02" version="1">MGGASWLRRLRGDMFDGEERMNVQKCKATVIAWENNENEARATSSCETKKRRLGQSTIERERIPVGQSIGRDWGSINQSKPSSILRSGLYLPENFASHSCIHCVVIHSSRRLHLSLDWRLEAVHRSCRHDACCASEPRTDLMKTAQKPLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9F8</accession>
    <name>A0A1C1C9F8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lipocalin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9F8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06345"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07831"/>
    <dbReference type="eggNOG" id="ENOG502T46B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3904217at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024311">
        <property type="entry name" value="Lipocalin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13924">
        <property type="entry name" value="Lipocalin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin-like" evidence="2">
        <location>
            <begin position="26"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="188" mass="21179" checksum="3F99C265771E937B" modified="2016-11-02" version="1">MSASTPVPQDLTSTPAAMTSFRSRIIGTWDLVYYIAINPEDPDDIVYPMGNDAKGQIMYSSDGYMAALLQEGNLKPFEHHWKHGNTEELATAAKKTMAYGGPFYLDEDPGKPQTIVHHAQISMHPNLINTLQVRRAELIQEDGREGLILGPESPSEWEGTQRLLRLKWRKRSQNNATKPPHDARELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9H0</accession>
    <name>A0A1C1C9H0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9H0"/>
    <dbReference type="STRING" id="86049.A0A1C1C9H0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06003"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07838"/>
    <dbReference type="eggNOG" id="ENOG502SNAB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF110">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="299" mass="33607" checksum="3197A7356DDAC0F7" modified="2016-11-02" version="1">MGSNPAATAESGDNYILSRNFLSSARLTAQHCLFVLKNGFLLHPKIAKYIQHTSTRTESLEIADIAAGNGIVGLTLAHEHPQAKVVALDISAEQYPPVWTRPENIDFGIWNFFDPLPEEFVGRFDVVHVRAICVPLMAGGIEAVIKKLVQMLKPGGYIQWYETVSKCFAELDQSLDPLPLSADYFRLFDKYVGLFSSIRQFDRLATELESEGLVEVERTDSPIMPYLLKQETDFVLWSCDEVLDTLRRRGGILDMKELEVARDQLTAEVARGKCLTYTMATFIGRKPWTVVNKECEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA21</accession>
    <name>A0A1C1CA21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_06243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA21"/>
    <dbReference type="STRING" id="86049.A0A1C1CA21"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06243"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07952"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877:SF2">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650700" evidence="3">
        <location>
            <begin position="22"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="89"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT45311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="257" mass="28331" checksum="F1EBD35E7E8CF6A0" modified="2016-11-02" version="1">MASSPTLTLAPGIHLVSTAAAAATTTAAAVDASSDSGVSFLIDGIVNLHAACILHDHTLATFLPPLSHSQLYQWWEKRLGEVTACERHIIVYVSNVADRTANHDLKAPWAAEGRDWPAVLRVPTDGDGDGDAQAAALEISGVVSLGTPFSQTGPFRAEVQKLFVHPMHRRRGIARKMMARLETVALDHGRWNLMLDTEVGSAAEEVYPKLGYERLGVVREYGYSLRDGRLVDEMWYWKDLRKMARLKEEEGKEKESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA42</accession>
    <name>A0A1C1CA42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA42"/>
    <dbReference type="STRING" id="86049.A0A1C1CA42"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06068"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08034"/>
    <dbReference type="eggNOG" id="KOG0372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901525">
        <property type="term" value="P:negative regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="327" mass="37193" checksum="1C249938BF85B5B6" modified="2016-11-02" version="1">MPGLPASIDLDQCIAQLYKKNLLAESLIEAICAKAKEMLMKESNVVHISAPVTVVGDIHGQFFDMLEIFKIGGFCPDTNYLFLGDYVDRGLFSVETISLLVCLKLRYPHRVHLIRGNHESRGVTQSYGFYTECARKYGNANVWHYFTDMFDFLTLSVVINNQIFCVHGGLSPSIHSIDQIKIIDRYREIPHEGPMADLVWSDPDPERDEFSLSPRGAGYTFGGDVVKKFLQVNSMSHILRAHQLCQEGYQVLYDDRLSTVWSAPNYCYRCGNLASVLEVSDAGDRYFNIFDAAPENDVHRNEQQQQQQQQQQTQGKDSQGSHIEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA69</accession>
    <name>A0A1C1CA69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_05856</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA69"/>
    <dbReference type="STRING" id="86049.A0A1C1CA69"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05856"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08019"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="7"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="472" mass="52237" checksum="E22E0D04737B63EC" modified="2016-11-02" version="1">MAPVPIQVGIIGAGMGGLAAAIALRRGGANVTILESTTELGEIGAGIQIFSNISKYLIRWGVDEIIGDNLVQVDEVRTWGVDGEVVTRVDPKRVHKITGFPHLIARRDHLHAGLTESARRHGVDIVVGARVKEVEYSESSATVTTARGASYTFDLVVGCDGIKSTIRQHLFPDVKPQAPSKVAAYRGVLTYDEIRAKAPEAASVLTNTMDMWTGPNGYIMTYPLSGGKELNVVTSFCKDYYVEKMEEVDMDEFRGYYKDYSPAIQSIIRLVNYTQRWPLLIMPFMARWSNEFRNVVLLGDAAHCMQNHVGQGAATAIEDGVFLGRAVSEVVRGTITIPEAVSIYEQKRIPRAWTKQQVSFVSGELNMCSDPDDLRRRNSSSLPEVQGLEEDEARPSFPPLPSEYRSWQMFDSPDSVPGIFYYDAEGDADNAVCEFLQTRDRENGAVDGLTMVSRALRRKWWASLDFNGVVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAC6</accession>
    <name>A0A1C1CAC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAC6"/>
    <dbReference type="STRING" id="86049.A0A1C1CAC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06439"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08064"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="121" mass="13887" checksum="BE7FBA837F39CDF2" modified="2016-11-02" version="1">MITDTESVIPCLFAQYGCQQIFLGDSQLRNLDECRRKILAAHPSVQVLVKEFDRSDEADVDAFFTAVVQSFTRIDFAVNLVCQDQNPRATVDISAEDYTRSYTVYQRGVRFNYPLDQFEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAJ6</accession>
    <name>A0A1C1CAJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Fn3krp</name>
        <name evidence="4" type="ORF">CLCR_01618</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fructosamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAJ6"/>
    <dbReference type="STRING" id="86049.A0A1C1CAJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01618"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03481"/>
    <dbReference type="eggNOG" id="KOG3021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1200.10:FF:000018">
        <property type="entry name" value="Fructosamine-3-kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="340" mass="36404" checksum="8C64E90D788937D9" modified="2016-11-02" version="1">MSPSIDPAILRALNLNASSAKISTHGGSGFASTFRITTPTTSIFVKQSQSSGAKVMFQGEHASLNAIHEAVPSLCPQSFAWGSLENNGGGGYFLATEFLDLGGGSSRTKAGARTGSGMSLAEKLAKLHTTPAPIPEGFDAPQFGFPVTTCCGDTPQDNTFTTSWAEFFAKRRLLAILERGEKTNGRGDAELRTLVERTVNEVVPRLLGDGHLGGKEGIKPAIVHGDLWSGNKSKGFFVGRGGDTSPDEPGPSEDVVFDPSSCYAHHEFEFGIMNMFGGFGSSFWKEYHAIVPKTEPAVEYEDRVALYESYHHLNHFAIFGGGYASGAKRILKGLLKKYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAM2</accession>
    <name>A0A1C1CAM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_11232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAM2"/>
    <dbReference type="STRING" id="86049.A0A1C1CAM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11232"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03485"/>
    <dbReference type="eggNOG" id="KOG3437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="7">
        <location>
            <begin position="108"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="363" mass="40110" checksum="2FF76373D3E4CFE5" modified="2016-11-02" version="1">MPRAPRRAAHQARQNEVTATPTRNALTAEIPPFMLETPPHAPFLTTPLPPSNNPAATTVPEANAPQRQQTRNQQAPAGNGNGNTPNDAPEQSQLSQPLVPTSENGNEDDQSFLESVHHDIEDARQLRGLRDISSLATWTLSSAKPGCALPQLRNPSPSFFWQSDGPQPHTLTLHFFKLVAIVKMRIYLDFELDESYTPTKMKFYAGMSEGGLVEFGTWEVTETADPESGEMHSSIEGVRGWIDVPLKGVGGRESRYHGSPDLLDDQEEPTLYPLRSNLDDSVGGDVLKAMVVQVQICENHQNGKDTHVRGFQVFARDYTNHGEVRTTKKIKQGKVQPSEADDDVVTKIHGLQPADWMGDPEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAR4</accession>
    <name>A0A1C1CAR4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transporter MCH2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MCH2</name>
        <name evidence="6" type="ORF">CLCR_01536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01536"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03487"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="245"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT45576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="438" mass="47894" checksum="55A7AD04D72DD82D" modified="2016-11-02" version="1">MSENDLEKDGDELPVPLAPGQPPAAYDPSEEPRYGWVVCIAMHLINGFTWGIIASYGVYLSYYIDHDIFSGASDLDYTFIGGVNFACAMLSGPIVNVCIRKAGVHVPMYCGCIMFAGGFVAASFATEFWHLILTQGILVGLGTGFTWLPATPILPQWFNKNRSLAQGIAAAGSGTGGIIFSAATTPMIQSISLAWSLRITGILAFVVLATATTLIRSRNDMIRPHFKAVDTDLLKRYRVWLLIAYSFFSILGYIVAIYSLGQPDGSEIVTCAFATSIGLTQDQGGIVITVLQVGTAIGRPFIGVLSDHFGRMTVACLLTASNVLFTYAIWIPTQSYGVLIFFALVVGATSGVYWGTIAPLSAEVVELKELPSALNLMWITVAFPALFSEAIALEIRRPHSSRPYLWPQIYTGLVFLIASLFMLELRRQKWGFKRERHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAS5</accession>
    <name>A0A1C1CAS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lin1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAS5"/>
    <dbReference type="STRING" id="86049.A0A1C1CAS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01566"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03479"/>
    <dbReference type="eggNOG" id="KOG2950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="331341at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="406"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="462" mass="51936" checksum="A75DC90EEE362E6E" modified="2016-11-02" version="1">MAYNAPRNKRAAEDYVRTHDPDEYSQPSKKPRFDVRNPSALAPDALEDDAVLQADVIGARGQQVKRGAVNIDGYDSDSDNDNFNARADRKAKAKEKAEKEKSRDEEENDMFADLDDDFKDGDDSEGDAGRRDGKKRAVRFIDADEIEGQIQSSKSGGHVSADFSLNGRGKGKGREQDNDVESSSESEVDDEIRADTGDLDPELGAGSKKDHAPKLDAFNMRAEQEEGRFDDQGNYIRKAVDPDTIYDIWLEGTSKKDMKKAKEAAEKREEERRKRDFADELKSTGDVLAELIPLLNRGETVIEALARLGKSKEKKAKWLNKNKHKKQNGASEDQPLLEDDAAEQLRKQKIETITGAADFLLTKGQAEVYDDEREMLIRQYRRETGNDWIDPPQPNDDDAHDGAAMVQMWEYRWTDARDGGAINGPYDAHTMRQWNDAGYFGEGVEFRKKDSGGGWTRVAEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAU2</accession>
    <name>A0A1C1CAU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAU2"/>
    <dbReference type="STRING" id="86049.A0A1C1CAU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01412"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03473"/>
    <dbReference type="OrthoDB" id="4151433at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="771"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="797"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="276"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="437"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="677"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="772"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="797"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="847"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="873"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="920" mass="103795" checksum="2525CF0DF52ED020" modified="2016-11-02" version="1">MPGSPLQNLPPTANDQRSPARDPRIRNRTGSAHVVDQNADTGRGPLSDFRESFRKGDDTPSTTTPQSPSVRLDNPFPVPNDQPELLYSFSRHIHNSQSVDFLSRKLAYLRSERSAARADYEKVRKERDRFPVVVDQARDRVSKIEGVYKAVRQDEANARAAEEASGGKLITVLLERVKDMVEERDVLVKEKDDAHKLLTEQVGRMQQQLQTVFSQQAAAAAQPPPVSNELRIQLQKLEEFRAQQESENKKFSAIHDKLRGLEEMRSELRAISKAASHDAMQAIEALKSEIESLQRRVETLEQKLPPVESQLVDTQTLRAMERQLEEQFQQIKDTSRSHQQVVDNVERLRKTMHLKVENMHGELRDDLSTIKTDLRTLSSLVSGQGEDQSKLTARVVALEEFVSPGSQGSGGLQTEIDTLKRADQDKSEKVAALDTSLEELAGRFDSLETQLAHFNANPHTNSAVEELTSYRSQLAERIMEWKSSEEKLSNELSGLQQQVKDAITRPSAYKAEVDKDLQTLKSQIADHASKRTKWEDTLENEVKTLTTNFVEQAGVQARDVKKLETEFAAYTETWKRSETERNRTLVEAVDKLRDEQAAMRRVLAQRSTQGLSEDERHQVQHAASLASNVQELGTQVTNVQKDLEKQCHLTVSLTQRFNNLTTDELARRMTGVVSKALPKYEKQVQKLDDQVQKLDSELQALCQEVGVRAKAEGATLEVEKRLQELKAGVEDVAAKFQSSHDALAKNFAEARDKIQSQIEELQENHRELEVSLEQNEASQSTYRESTAKTLTAFETRLERIGGRSERPAKPAARELFPNSGHKKPSGVNPLPRSTSDKISLPRKMTVDDSDDEEEDLDSADILAKFTKPPPQQPRSSSQRQSSRKSTQSGELSKRKRSLSQEETTEAEYSIKGRASKKSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAW3</accession>
    <name>A0A1C1CAW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_01598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01598"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03532"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="320" mass="35921" checksum="DC882916C37B9088" modified="2016-11-02" version="1">MTAHDETRRRSVSCYILQNDMAFFGTLSVASAVRDVLLFGGFPLTRERATCERIVVRLLREALQRDDVPAELLIWAIYTQTALHSKSDAVSPSVVAARICRSGTPRQSDPDDRRFQVAFPPRGVINISVRIPFRFLIVRQRNFNFNALDRSFLRDGRYQEYDYARLAVLDMERADPSIWGPMRYPRHPFAAETCAKLVTLPPGLTALYRTGSISYPVINALVMISRNIGSADLVSTNATVTDHARTLNMQNRISAAICIRLLQTFSLSLIKQVLLLAVSAYCFFRGGEPATWQNADGFVQVGCLRLMSQPLPDTDAKVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAW9</accession>
    <name>A0A1C1CAW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DPM1</name>
        <name evidence="16" type="ORF">CLCR_01639</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAW9"/>
    <dbReference type="STRING" id="86049.A0A1C1CAW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01639"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03526"/>
    <dbReference type="eggNOG" id="KOG2978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="15">
        <location>
            <begin position="56"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT45617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="292" mass="32827" checksum="3592996C3E0163B1" modified="2016-11-02" version="1">MTPLLGVSHDYPRADPQPARPPANNFVFLETLNNRQIANLAGDLLAKMSAKRDKYSVILPTYNERENLPVLVQMLSDTFTKERLSWEVIVVDDASPDGTLERAKELQNSFGKEHIILKPRAGKLGLGTAYVHGLQFVTGNFVIIMDADFSHHPKFIPEFIKIQKDTGADIVTGTRYRSKNGLVGGVYGWDLKRKLTSQGANILADFLLNPGVSDLTGSFRLYKKEALVKVIEKTQSKGYTFQMEMMVRAKAMGLKVEECPITFVDRLYGESKLGGEEIVEYLKGLLWLWWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-11-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBA6</accession>
    <name>A0A1C1CBA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_01746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01746"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="145" mass="16162" checksum="9A15707640FD80BA" modified="2016-11-02" version="1">MALEMAKIRAEMILARRPESVLFTVLSASAHVGAVSISYASKSPDAISVIVATIGLKLCPWHDRHARELGDIWWGWVMAGDQGHKERALVTFRTAMEDNLDTVEITQGRDKRFGRGGEQEDFACLFAVVVDVAAQKTEKQHVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBC3</accession>
    <name>A0A1C1CBC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S ribosomal protein L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplA</name>
        <name evidence="4" type="ORF">CLCR_01699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Noorani M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBC3"/>
    <dbReference type="STRING" id="86049.A0A1C1CBC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01699"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03668"/>
    <dbReference type="eggNOG" id="KOG1569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1747252at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000001">
        <property type="entry name" value="50S ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="231" mass="25307" checksum="C6FE940DDC48C2F4" modified="2016-11-02" version="1">MQQFTLCEAMRYIKAFELGQNPDTPKYDIHVKLRTKKDGPIVRNNVRLPYPVKTDIKIVVVCPPDSNAAKGARAAGAYLVGEEEVFERIKAGKIDFDRVIAVPESLQKMNKEGIPRILGPRGLMPNVKMGSVVTNPGPAVRNMMGGSTYRERQGVVRMAVGRLSFTPEMLRDNVKAYVTAVKKDAAALSDQIAKEVYEVVLSSTNSPGFSLNGDFYRPGPGNATPQQLAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC63</accession>
    <name>A0A1C1CC63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Raffinose synthase or seed imbibition protein Sip1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_00368</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-galactosyl-(1-&gt;3)-1D-myo-inositol + sucrose = raffinose + myo-inositol</text>
            <dbReference type="Rhea" id="RHEA:20161"/>
            <dbReference type="ChEBI" id="CHEBI:16634"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:17505"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
            <dbReference type="EC" id="2.4.1.82"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolases 36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC63"/>
    <dbReference type="STRING" id="86049.A0A1C1CC63"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00368"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10354"/>
    <dbReference type="eggNOG" id="ENOG502QPVE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047274">
        <property type="term" value="F:galactinol-sucrose galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008811">
        <property type="entry name" value="Glycosyl_hydrolases_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268:SF32">
        <property type="entry name" value="GALACTINOL--SUCROSE GALACTOSYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05691">
        <property type="entry name" value="Raffinose_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="988" mass="110478" checksum="EF710E58DFCB6374" modified="2016-11-02" version="1">MSLSNSLSPSPLPPVDDTPSKPTQIKFYRPAQMALFAKLATYPPLAQVTVVSPTRDKRVAAPDRSTDFLHENDVWTDPPLFITLTRPQFNFTVVLESSRSLPERPWEVSIWYDHGSYAGTKSPWQALDLKLEHTTPAVLYDDTQADNYRYTFSGDLESPFVSFGRTYKGRRVPFTVRFRVDPNAEWSWVYHNFGIKDGELILQPPIDPNFLGASPVEVEEGWTLRKTPSDAPEARLYTIESAHPIPTPAAGNATAESFVLGRVTQVCRWLALVRIWEPWFAPRHGENRLHLSEPAILLSFLRSDGLHVVLLAVNGIDEALTEFTSTHDGAIVVRARNDTGRDRKYKILAASAWKFEIANAAVMYEMRKLVRQSKAYHQALEQLERLPRSIRSESLDSDTVLVNHEKHPTNDPALTPQWLGSWYDSLAYCTWNSLGQDLNAQKIMAGLDSLAQHKIYISTLIIDDNWQSLDGTQGETNQFQRGWTDFEANPLGFPEGLKAAVDKIRETHPKIRDIAVWHALMGYWGCVSADGKIAQTYKTQEVTFREGTPMAGRKLVVHPDDIHRMYDDFYRFLSNAGVTGVKTDVQFALDLLNDTPDRRSFTNTYQSAWTQAHLRHLSGKAISCMSMLPQILFHSFLPTTTPRILLRNSDDFFPNVPTSHAWHIFVNAHNALFTQHLNILPDWDMFQSSHPYSGFHAAARCVSGGPIYITDTPGEHDVGLIQQMTALSPRGQTVILRPSCVGKTMGVYDKYDEKGVLKIGAYDGKSDVGSSFLGVFNIAESETSFILPITKFPGVNAPASSTGNTEVSKDNWIVRSHISKRITPPIHPADPIKPDNLLQCTLPIRGYDVWTALPVHTFRLPASDSDLGVAVLGLLGQFTGAAAIVEANFNLEEVASEGVSPRLKIHVQLKAFGLLGIWLSDVQSRQRKVEDMMVIIQGRAVPQHVVGFETEHCPAESGVLVIDVGKAWEEMELEPGWSNEVGVDVFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC99</accession>
    <name>A0A1C1CC99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC99"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01363"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="79" mass="8698" checksum="412E83600E844EBC" modified="2016-11-02" version="1">MPGSVGGAMFGPSHEGFGSFHYSRPSTLGDGPNGPSSFNAEARSAGSYSYQDRMHDLPEQKKEMRRDEAGLRWVLKKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCV5</accession>
    <name>A0A1C1CCV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_01210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCV5"/>
    <dbReference type="STRING" id="86049.A0A1C1CCV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01210"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09221"/>
    <dbReference type="OrthoDB" id="4142959at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="337"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="410" mass="45923" checksum="99FCE1A9933253C2" modified="2016-11-02" version="1">MADSHESTVLPSGQADAILSPVPERPNTHNSSDDPQASESARFSAWRVPYLTTEVPLGHTNIDGILRFVDAFVSEYLPSLPENQRGDSIEEFAYNLPTDLTIEDQATVGLPRAIELLSSDEDDPMPMEGLDDDAARRAGNFPWFAPSTIITRDPPSSIVPFYDPDIEGAAALNEIRIWVRELFSLSSLFFDIQAQMSSMVRDMGASDDPLRLNAQRLLNEAVDDLLQVSLPSLFELSLDNVQPRAESLADAERHIVTAKEKLFLAEAYLVSQEALLLANGDEFKAHASRYERTRYRDHLRWLVSNFQTARLRGIFVCSSGMGLEPVTRSYDTSEDSCPVCREDLPEEGEIAHPPAVSFACCNKGFHVDCLLEWLFEHFSEDMDCPMCRKELDLDFLGALMEQKVQELQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE68</accession>
    <name>A0A1C1CE68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11253"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01473"/>
    <dbReference type="OrthoDB" id="10590070at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="162" mass="17302" checksum="EFA99F147211C144" modified="2016-11-02" version="1">MEVFDIYHSIDHAQGPSPLTQVDFFHTKHRAIKKAHAEVAARGLQPPKSVASSITDGAPFIHTPRKGKHAAIAGDSDASKMGAVSPAGNSSSNSRKENFRDMSAASSSSDTRKQRVVVHRDDEDKTPSSKRSHIKSGRANDGESLPAESNSTMLLGNTSSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CET6</accession>
    <name>A0A1C1CET6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CET6"/>
    <dbReference type="STRING" id="86049.A0A1C1CET6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02490"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02453"/>
    <dbReference type="OrthoDB" id="10447006at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="39541" checksum="DB9B6CEE8F1D800F" modified="2016-11-02" version="1">MSSSSSTSHRLKRKADAMEDESLKQPRCIDVHSEGKVLVRIGKGDAARTIRVSGPLISHAAPSFGPLSSAPVEGGDRVITVENGSPEVYLDFFNIIHYKHANVGKLTGQRLGQLAELASNSWLFPVIHEITNASNDPTGMKSVIYTLKQHQVTFEELLDIAVLCEMDELFWRTSKVAVAEAPKPLNPRSSSVYYVQRSKLYGEINMARERAIVKFLFDVFEWIGERHPITPNGEYATEALTNYGKLHYLLRAEGIIAHKISNYEGSLGQAIGVLSRIIDPAKAKANSQDALSAGNGTIVDRQKGSGECLGRDIKGDLLRLIESHSQRLRGLALSVVGSEDFLSLDVGWWRDEAEISDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF46</accession>
    <name>A0A1C1CF46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF46"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02681"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="106" mass="11643" checksum="2A65A195292658DA" modified="2016-11-02" version="1">MAGLAMETHFSQSQWPNQATVTRVRKRNSQAKSLTSAPGCPQQAELGSSSDCARAQSRTCRQTRLTAPERKNVRAQTGVWEMMFSRPVRSGTLGDSGRSQEGTGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFE7</accession>
    <name>A0A1C1CFE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 16">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CLCR_02220</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="16">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the LTN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 16"/>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFE7"/>
    <dbReference type="STRING" id="86049.A0A1C1CFE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02220"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02174"/>
    <dbReference type="eggNOG" id="KOG0803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6108at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="1548"/>
            <end position="1594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT47255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1600" mass="175214" checksum="A0FD71D2E52A735C" modified="2016-11-02" version="1">MSKKFKSQASAASARAASATFGSFSPGPSFGAPGLAGFRTAPSPLSYIAEQPELSTITDANLVVTLRNLGKKDSTTKAKALEDLQDYVGSLGSGEAIETGLLDAWISLYPRTSIDNSRRVRQLAHTLQGSLTTLAGKRIAPQLPKVIGAWLSGLYDSDRLVARAAQDSVSTAFNSEDKRRALWKVYRGALVDYANDAILVQTPQTLSDERSTTPDNAESKFVRVVGNAVQLLSQIVKVNYPAGRADKLAGLDSIKMILEEKKLWEYSSHQDPTLRRALCSLAKTCADTIAHELDWKTLSGCFIGKALHSNQLGSSRQLSEALLSLTSVRPEIWTIDYTSKTAASKRLFQFLRKGSQRGPVEFWSDVKALIKGIPLEAWSTIAEDGKVRLEDGAVLLESLRAGVTSSEEPRQNLEAAWSSYVEISFWLLERLGDEQSRVKLLEDNALPLVTEYAASEPSTSLWVLPSTCNAEIAASILVSILHRGMHSCFETTWTRLCQSLGDHMKLSLPESSKDFVKSQDKVISQVQRLFRLKRIILDAQHLPSSEKPQVADVIRRSDESLVVAAIELLKARNGKPYGAAGVLETVVAPTETLSKSLELFLGSDALRLLASPSAEYLVALLLRARASLAQVFTALVSAGDGPSASAALGRLAGDLSEEECLQIPDFEPFIVERISSQLETSTTQQVVKSILQNPKLTSSALHKRICQRLVDQLSPDNGDNSQQVVLRFVLSLLSDRTVNPSPFSGDVARLLLAKLLLLTESGDEETAELASALLGKLKSTPTGTSSTAVSSAALVADQLSGKGDPLPVFVLVDLGKDTLKALSSPHGNMLDSLLPTTAQWENSLKDHITRPPPPSISITSPLRGLISVITPVHASTPTLSRDSEGHSYLFRLFLYVTKMMHATNLSTVQSEEQLLTLYTYYPLALEIVNENLTMESQDGLWHNTSNEVVEEAAEALSQGTSLVQKWLQDDKFIKLWVDAIRSTDSLDPGAYYHGLAFTNIASGFVDEHGSALLTSAFEAEIKDLHHADEVVRSASLVSACRHYFISSQQGRKLLNELIGAVTGVNVPSTSNMALRPLILLDILLSGSPEPVEGIPSQRQNFLMQTLVRILSDPSAESNLQALTIRLLEPIVAAVKDLYGEHWERMLHGLAAILQNRTSLNEDLPVLHASLRLCGRLRTLAKSDGANEDLVEAWEATESSIEEGLLDCLRGFSDSLNGTNQPTRITAELLRRQLSQIPARHDVSLYPFLSSAVDSVQGAAYDLLHRSIPAEQEQVSLDVALEQKAAHLPTELLELLLDMPQTSARTDVLLQRGYLLCWSLVFDHFPKASYKLQELYTADLKEKGVVGDLLELICDVCRITSSHPLDASKTQLKDFEIGTSETEKQEEQRLTLHLYYCCLLFLPGLTRSWFIEQKNRVKSPLESWTQKYFSPALISAAAATVTNWVQSQSQDEGDSPMTIKTSLSGSETVASIAVDPESPPISLAISLPKSYPLDSPSVFSRTRVGVSEKNWQSWLRTIQIIIFSTGSIIEGLVAFRRNVQGVLKGQSECAICYSIIGTDMQIPNKRCGTCRNTFHGACLFRWFKSSNSSSCPLCRNNFNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGE1</accession>
    <name>A0A1C1CGE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ketosteroid isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGE1"/>
    <dbReference type="STRING" id="86049.A0A1C1CGE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03740"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01806"/>
    <dbReference type="eggNOG" id="ENOG502SUCE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264449at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41252">
        <property type="entry name" value="BLR2505 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41252:SF1">
        <property type="entry name" value="BLR2505 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="142" mass="16163" checksum="39331FBA028D2A4A" modified="2016-11-02" version="1">MAKSSDIRALFEPLSIQGRQHETLDLLADNVDWTIMGHSPMSRKYTGKQDFVDNTLKVLRERVLTEPLRLEVKGVVGTLEGEGDDIHGEVAVELAAIEAVCKNGLTYDMRYVWICRFQRGRIVRVRAYLDTDLLSRAMEQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGP7</accession>
    <name>A0A1C1CGP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoporin pom152</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pom152</name>
        <name evidence="8" type="ORF">CLCR_03262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGP7"/>
    <dbReference type="STRING" id="86049.A0A1C1CGP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03262"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04647"/>
    <dbReference type="eggNOG" id="ENOG502QQ5B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5529162at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056541">
        <property type="entry name" value="Ig-like_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056542">
        <property type="entry name" value="Ig-like_POM152_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056543">
        <property type="entry name" value="Ig-like_POM152_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056544">
        <property type="entry name" value="Ig_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037701">
        <property type="entry name" value="Pom152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056540">
        <property type="entry name" value="TMD_POM152"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206:SF1">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24312">
        <property type="entry name" value="Ig-like_POM152"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24519">
        <property type="entry name" value="Ig-like_Pom152_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24527">
        <property type="entry name" value="Ig-like_Pom152_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23664">
        <property type="entry name" value="Ig_Pom152"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24097">
        <property type="entry name" value="TMD_POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 N-terminal transmembrane" evidence="4">
        <location>
            <begin position="70"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 first Ig-like" evidence="6">
        <location>
            <begin position="205"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="453"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="3">
        <location>
            <begin position="557"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="758"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="3">
        <location>
            <begin position="876"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 ninth Ig-like" evidence="7">
        <location>
            <begin position="1081"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="1180"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1280" mass="141884" checksum="193CF3CD8079C17F" modified="2016-11-02" version="1">MNETPRLRSAFPTTPRTDPRARNLNLNGRPGPGSSPLFPQKPSPVVKQPVKISPEAVATSAPLIPIDIIDVPQQRFYVFAFYIALTAWRLYNSFSVESDLDSTWLFLKWVGIDAAFFVALPAFKIPWLEFSFLTTFTLWLLHAIANAFLMYKIPIPMLTWLGALVKVAYDRELSLSEHRVKPADILQNSSIILGKQIIHILPEGSAILNPEKKSFCLDPSNPAADLPIQINQTTPISIELQRYDLDTDEVETITIGSKQAKQLLKKANAGHHKSDTNTPRILHYPVSKKGLYQLHRVIDATKLEVRRRSFDVAVVQCPEASISAELEDRCTGELSNVSLKVSGVPPFKVRYSKTVNHKQFSSIVQNVQPHVDPDLVADDESAGVVLDPRRPHIGWTKSTTESFEINESLHQNGSHSYTVEEVEDGLGNKVNYDASNPKHAHAPRVQSLTVHNRPRITLGGLHVDRVLRAPEGRAINLPIHIPQPDSLHSSDWPLKVSYSFISEEGQEDSQPEHHTYDMANSHSTPLITVPGRYSLDSIGSQYCHGEVAEPSSLLLSNPPKPGLSLEKEDIFDKCAGNPIGMYLNFDFTGSPPFKVRYVVTHQGRAHGKVEEFPGMRGRIELRERAAGSYTYRFRDIEDQVYGVVPLKDQNLVLQQDIRPPASASFHGDGRAIKACLGSPVSVPVRLSGHGPWNLDYEVVHAGKRKKYSISSEEELYNIELSPFTNGGSYSIVLMGVQDQSKCRTTLQEERKIEVRPEQPRAAFGDIEGKRSILALDGKSVKLPLRLQGIAPWAVRLQNLDQESDSFEQIFKDANGELSVNRPGTYEIVSVHDSCPGVVDTKANKFEVSWIARPTLAIKDSAVDKGSVRSFRKPAVCQGDEATLALALSGSAPFHVKYQQKFEPIKGPSAISNKPATFAGVNAQINLDTSRAGEYTYVFSELSDARYSHDNKAFTPTIVKQQVYAPPSAAFGQAGKTYGYCKDDPSFTASVEAETEQIPIKFTGTPPFSVEIAITHHGVSTRPEIIRQKDIQTNTYSWPLSRATLDLGTHAISIRSVKDGRGCESILDSDPSSVRVHVSSPPTIIPLESQEHYCVGEHVSFSLSGQAPFDIFYSFNARERKARVSGTEFRRLAESPGEFIITGVSDSAMGHSKCRARKDIRKQIHAFPSVEIAQGRTVVSDIHEGGEVDIEFRFTGTPPFEFTYTRSENPVRGKKGSKPRILETRHDTSDEFRKMIRASDEGIYEVVSIKDRFCSYTKPSHKLSSGGGGLLGGAGQKRLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH24</accession>
    <name>A0A1C1CH24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_03357</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH24"/>
    <dbReference type="STRING" id="86049.A0A1C1CH24"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03357"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04591"/>
    <dbReference type="eggNOG" id="KOG2150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex, subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="13">
        <location>
            <begin position="500"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="251"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="496"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT47751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="632" mass="71147" checksum="0083228619C32260" modified="2016-11-02" version="1">MASRKTQQEIDKTFKKVDEGIQAFEAIYEKIYSSQNAAQKDKLEDNLKKEIKKLQRSRDQIKTWAAGNEIKDKSALLEQRKRIEKCMEIFKAVEKEMKTKAFSKEGLSQNVKQDPKEREREELCDFLSDQLDEINRILTEELEPEAGNLQAALKKKQKDNSKADRLAEIETMTDTYKWHESRLQLLLRSLQNGNVENDMVAAIKSDIEEVVREGREPDFDPDAYEGIYDDCNLDSEEAQFGLNNDVDRISSQDTQSIQEDVEPEANPLKKTKSEPHTAVRRPSTQLKSPLPALATLNTMPPPPSIPKDTTMKPAPIPNRPPGETLKYASAAAAAAASDKSGVGIAPLPPPVATSSAPPSHPLPAPVKTSAATSPASVPAQPVEKTASPAPAAVSMDGSASQEQSNHSKSPTLSSTSAPAPSVPSSIPPTPAMENSEAVQEPVIADEIPTTNGNVHEDPSAVESIYHLPPGLQDLLDSFETTKTRAAQPPSQLARLLQASQETCPEPADSDRPQYYRPTFKYNTPAHYPQDPLPIFDDPALYENQRLETDTLFYIFYYRQNTYQQWLAARALKNQSWRFHKQYQTWFQRHEEPKQITEEFEQGTYRFFDYESTWMNRRKADFKFVYKFLEDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHK4</accession>
    <name>A0A1C1CHK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_03843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHK4"/>
    <dbReference type="STRING" id="86049.A0A1C1CHK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03843"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08165"/>
    <dbReference type="eggNOG" id="KOG4532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2415" evidence="3">
        <location>
            <begin position="292"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="752"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="566"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="717"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="752"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="955" mass="105872" checksum="AA218AEEE62835D5" modified="2016-11-02" version="1">MTKANRELWLTPTEKLATHHKFYPTKIQVAHHQLRHLISSAERDLIYYVSFRDVYVLDLASHQNSLIATVPFDTRCLTAGLGWVCVGGEQNGDCAFIKVEKDEHDRPICFGHDFNHDLLGGEIVNSMSIHTILNDGKTPDEPVVLISNNDKTVKMYSLAQRQVLTTLPHTVPMNFAAMSPDSSIIAAVGDSDRVYFYARRLYQEPDLIDGSSGRYAKYEWDMLADPQVPTGDPVYDDYSFAVTFSPSGHLCAASSQGGSISIFDLQHLRNNEDPGESSVICTFRSSRAALYGCVRAMTFSPAPWDLLVWAEDHGRIGVADVRRACVRRQMLELDPRKAEEIKLEDGTPMSYRNISHKEKIKQQHLTRLRAMRGLSSTRELDGELTIDDLPTESARRYSRQDLISYRGLDLDARERSVTEALETTMDDVEQPPPRPYSINYTSSPRWFASRIPATASPLSPDVGRSTSSQVHPPRRRSSVVLSESTGNAGRYLDVSDGRRARISASPGRMGDDDDLPVTSTDDLTPFAPGSTSQPMPSDIPPNDPSDAIHTTLEAARDTNNGPRVDLARIEAALEAERELGDRLERQLADERQLSLLLRRQLDTQQRLLVENSNQLERLRAAARETNARVEASLERVLQRQLAHEQHFLNQRAEELRSELRTGTDYSRRLETERDRILTGDPASSTNNPTSAWTTTLPTTSVRPSGNTNVLTDYIETRRERVAHIENLQRQVRRAESRVALAAIDMQALENAIRREMDTEETTRPRTRNATEAHPPQPATVANDSARLTTAPPRTASREPELINRPSVSNPSAPQRRDSPNIVDPSPRGLAVARQADFVRVSGLTGRVPDADMRLARMMFLSGMSGNRSLDANGNWMPPGAGAALHRILGAGASGSRGAAAAAGGVDVDVANPELGTTGIGFSPDGQFLYAGTEEGIFEIKVNLRDRMVFPAVEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI01</accession>
    <name>A0A1C1CI01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Caffeine resistance protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">caf5</name>
        <name evidence="7" type="ORF">CLCR_03955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI01"/>
    <dbReference type="STRING" id="86049.A0A1C1CI01"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03955"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08248"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="83"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="526" mass="58173" checksum="01A8C04693F5F4B4" modified="2016-11-02" version="1">MWHQLVHDSFTGRFLRYVSRGKLFPYEGDESPAVLKRFSVKEESPVEDAESAEEGKDPLLVDWYGPDDPENPLNWSSLTKAAVTFQLCFLTFAVYVGSSIYTAGIPSLIEDFQVSQVVATLGLTVFVLGYGLGPMTFAPLSEVPAIGRNPVYILSLALFVVLQVPTALSVDIGMLLVFRFITGVLGSPALATGGASIAELYSPQKRALGIGIWGLACVCGPALGPLLGGFAAHAKGWRWTMWVLMWIAGLNLLMLLVFLPETSSKNILYRRARRLRRLTGNDKLKTKAEMAFQQVTVVKIAQMTIVRPWVLTFTEPLIFLLHMWVALIFGILFVWFESFPLVFVGIYGFSLGQTGLAFIGLLIGGLASVPPFVWYCRSVQEKQFTESGQITKPEFRLPPSMVGAICLPVCLFWFGWSARPDIHWILCICGTAFFAIGTLLVVNSVLNYLPDAYPAEIPSVMAGNAFIRFSSGAAFPLFAPAMFHRLGIGWASTLLAFLTIVFVPIPFAFYLYGEKLRKRSKRARKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI60</accession>
    <name>A0A1C1CI60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ppk23</name>
        <name evidence="12" type="ORF">CLCR_04062</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI60"/>
    <dbReference type="STRING" id="86049.A0A1C1CI60"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04062"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08348"/>
    <dbReference type="eggNOG" id="KOG0663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="108"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="411"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT48200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="473" mass="52422" checksum="ABE3191A9B58E0F0" modified="2016-11-02" version="1">MASRSSKWTSADDDQESAAALAQRKKEKEERRRLKEERVRNATKQLDPPTDAAGSDERPTKRQRTSPETGEAVPTMTATNAQSNTEEGANILQFPDRQFGPCGHVDQFELLNDIEEGSYGVVSRARRKTAGTVVALKKLKMEHTSDGFPVTGLREIQTLRACRHANIVELQEVVMGDGGGLKDDNVYLVMEFVEHDLATLLGEMAEPFLPSEIKTLTLQIVAGVEYLHRNWILHRDLKTSNLLLNNRGEVKLADFGMARYTSRPPPPKLTQLVVTLWYRAPELLLGADEYDFAIDIWSVGCVLAELLTRAPLFQGHNEVGQLSRIFSLLGPPTKHTWPGYQSLPNAKALHPLLSNPKATAKTTANTLPASKFPYLSTSGLGLLSSLLSINPASRPSATEILNHAYFKEDPRPKAKEMFPTFPSKANQEKRRRRETPQAPVRGDAPRLDEQDLQGLFAGQAEEEQGAGFALRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIG3</accession>
    <name>A0A1C1CIG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_03810</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIG3"/>
    <dbReference type="STRING" id="86049.A0A1C1CIG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03810"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08388"/>
    <dbReference type="eggNOG" id="KOG2277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="12">
        <location>
            <begin position="110"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="11">
        <location>
            <begin position="456"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="600"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="763"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="843"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1014"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1101"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1242"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="641"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="763"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="802"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1014"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1032"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1107"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT48242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1279" mass="144463" checksum="C4F3C32CCFBFD8AD" modified="2016-11-02" version="1">MESRRQPGPQPPTFDYARHGTPREYQERARGNRRGGHYFGPHQHRAQQNPQQWSQPASPAQFNPNVRAPPRHGQLYNPNAGMHYGTVQQQRAMRHLIMKQSDYLTGIGRQVYGEFRFTQEERDVKENFRLALEQVARNAIGAKYPDLQLDQVKLKCYGSLANGFALKDCDMDLLLSLPDYEGTEVKEPEPTVPLDGDQTTASNHGEEQNGFKADVQRILEKAFLDHEYGARLLAHTRVPILRICQSPTPELLENLRKERAEWEKAIDHTGVTQEDVPETEVTPAELDAVEQAVTAISLDTKTAPAKRGNRGNRHNRGNAGLEFTDDCGIQCDINFSNFVALHNSTLLRVYHSFDPRVKEIGIFVKIWAKLRDINTPYRGTLSSYGWILMVLHYLMNIASPPVIPNLQHLAKIEDSWNPGRQIELFEGFDVRFVQDHQGLQDIQREMAANKNRESAGQLLRGFFQYYGTQQGFHWTRDVISIRTKGGIVTKQAKGWTEARWQQSQNKSVRNRYLLAIEDPFEVDHNIARTVGHHGVVAIRDEFRRACRIIEMIGTDEELPAENFLSPVTDRVDTLRKDLDYLKQRQMQMRQEVEAKETAMLERRTTENAELPATDGTWGKSKQGKAHNDSPSKSGGAFPESKLTSTPPVQEQKQLKTFRTWRRRKVSADTDDDEDDPTSQTSETNPGSADNLRSQAQDEPKMRNQGLTSRAEVLLANGLDRDGNPIPWDIETQDGRWLHWRDRKVKNGTIGPFFKESYRELNEQCPYDSRRPSPDFSRRSWNKDRQTAYERPPWPANNANKDNSMRPDSSHPHSGESKIAVSCANGACSQAKVPHLSEIEAAPAAVARRGSSNDERSNTMAAREQGKLPQPQLDARTVGAMIPWDHSTRGGRWLLSRDRRIREGTFKSRDQRGFYRKLDAEFPYKPEMTWAELDVLNELLRRYYKQSLRATRLPPGLSQPPAEPWSERAPFSQMVQNVEVTENHQSLSQAATAVKDCRSAEYGSSLACAVSIPTGPSSQAVPMSESHASQDTVSDRDPTTPPDNERVPDMDFLRMQRLAFFTKHMTPCSSAVDTNDLFFSRAQATVSVAPTHEIFQTPSAPQLPIEIPRPHEMTPPEPVSRKADAGADEDVDQPSHLSKTDFSELSVAFSDSPIIEDPVLRVPTTLYPDVADELRPRDENPDIMPIPRKIGFQFDPRQLQDLRVISKGGNGCARDGAQFILEEQEYEWGGGGMMGHKTSTGPQIATTTGGHAPYEAGKGDEEGLLDELPRLWDENSATNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJF8</accession>
    <name>A0A1C1CJF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ilp is an apoptosis inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJF8"/>
    <dbReference type="STRING" id="86049.A0A1C1CJF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05144"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03231"/>
    <dbReference type="eggNOG" id="ENOG502S2F8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5335812at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053267">
        <property type="entry name" value="Verrucosidin_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087:SF1">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25823" checksum="A0CB6807CC59E94C" modified="2016-11-02" version="1">MAFSSSSSESNFGSSSRSLKDAAFTGINSPSEAGSQGKPPSGPQFDIIAWFPRYQSCQRYFIDHAQHEPLVQAFASFINILLPFQRQPHPVYSTSGSRSGKSRLDKGDPVRASSSEAAAAASAVSLIPYLRRLVVTGMDVPQVLHGFFGDDWRAGIGPQREQERRNYLFAAKSGGWASVKKDYDMLPLETVPFMRPLYNPTDGELEAAERSWSEWLALEDWMVGSRAPGHSGDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJG1</accession>
    <name>A0A1C1CJG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PSP1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04580"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03245"/>
    <dbReference type="eggNOG" id="KOG4679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="627"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="879" mass="97916" checksum="1E0B06C36030D9D1" modified="2016-11-02" version="1">MSNAPSKTVLTTRAPMPAFGTFGGHQGSASLLLERSNPDLRRSTPDSEALASSDDEPDHTKAVATSNARPGKPGRRTSWLTDVSASNVNRKPSITGPYSPSTSHPGTPGAENSPWSNTNTSGSAAWPNPATSYPWNTIWNQDGRKDPPTRLQEVVSANGDTGIPFSIPLEPSFKTHRSLSYSVGQIDTTNAPPSNPISTSVEATRSRLGSQYPGVQRRTSRPGGLGGIESSGLGRVREVEDDEEYQRADAMRNALSIGQTHMMQRLVLENHQLREEIKNRDRALPSIAPTVPAQPPGFQNTRLRNAVPEESETAIDDRDDIAALGGFPGRDNNPRRMSEQTLSIADRQSLSPTENRAFDSMKKAHWQTSLGFGPIPEAPQSRRHSFADVPTRHGSFSSTGERLQGVHLRLLETDQLGRDEEVTAYESGSQALSQGDDRKLALALTLMHPNEDEMRIMYLRLRRYAAEYFNTNESTRRRADDRVHQQHREPQLYGQHFGVGPYLEPAAQPLFIVNFKCCRSEVFYIQEGTGLHVNVGDLVIVEADRGTDLGTVQHTNVTWEDARRYKDHYAEEHYKWLMMFSLQSRNGGPNVVNPNGAPGSRGSAVGGMGPQGHHGGHDSSGPDLKPKMIKRLAQNHEIQALKDKEGNEAKAKRVCQQKVLEHRLNMEILDAEFQMYVQCNNPRLPELTLRRDSKKLTFYYFADNYINFNHLVTDLFKIYKTRIWMSAINPASFQTPTASLGIQPLYAAAPGDERHQRRQPQRHQTHLSPQAVTTPFGDTFDADRKYNNSQNTGMRNAFYNQFQDVGAGSQQLQPPVPTFAPNMPTQMDPFMSYYAQPYPTLNPNAPNFASNRSDYRGRAPNQVHDPNWMGRFQGLSLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJJ1</accession>
    <name>A0A1C1CJJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flotillin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FLOT1</name>
        <name evidence="9" type="ORF">CLCR_04803</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJJ1"/>
    <dbReference type="STRING" id="86049.A0A1C1CJJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04803"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03261"/>
    <dbReference type="eggNOG" id="KOG2668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6080404at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF31">
        <property type="entry name" value="FLOTILLIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="8">
        <location>
            <begin position="10"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT48627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="491" mass="54654" checksum="5F0383557CD5684E" modified="2016-11-02" version="1">MPGMWYHISDANEYLVVTGAGVDDVRIVKKAFVYPWQRVARISVSPFDFSLNLQAMTIEKLQFALPAVFTIGPDNKPEALKKYALLLSGNPDGTAINANRPGRAIVPTQRHHVQDIVKGIIEGETRVIVSSMTMEEIFKERQVFKQKVIENVQNELDQFGLRIYNANVKELQDTPGSEYFAFLSRKAHEGASNQARIDVAEARMRGEVGEAGRKGQTKQEISKIEAETAVLETKRKAEKAQADAELTNRQTELNMGIQMAQIQARRAAESRDAELQKDVETKKAATELERLRAKDLVRAQIARETAQQEADAEQYRQLKAADAKAYAEKQDAEAQLFKQQKQIQGNVERQMKEADAMYHAKMREAEATQAQAQAFKALAEAFGGPQGLLQYMMLKENTYEKLATANAKAIQGLQPKITVWNTGAEGDASGGMGQGIAPIKNIMQSLPPLLSTVQDQTGITLPNWMMQMPPKDAPQMNGHSDVPDKKKMLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJX1</accession>
    <name>A0A1C1CJX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine/threonine-protein kinase ppk34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ppk34</name>
        <name evidence="7" type="ORF">CLCR_04828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJX1"/>
    <dbReference type="STRING" id="86049.A0A1C1CJX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04828"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03108"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000447">
        <property type="entry name" value="Calcium/calmodulin dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="147"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="449" mass="50365" checksum="A3CEDE265D9D885F" modified="2016-11-02" version="1">MRDPRPFTGPASIGAAVAARARVPPARYISVLSQRQRLELNVECLMDIVASPTSTSAEEGVRFPTSNTQPRDLVQSHGNPSDESTNAATPTKPPVVKHLSSPEYSTPSRHHRRTPSSAKQVKESLNARSEYVTSKDDGVAEHRINQYIIKQEIGRGSFGAVHLAIDQYGTEYAVKEFSKARLRKRAQSHILRKPLSQRRRGALQGFNSPLHRGFGNDGDSTSSPIDLIKEEIAIMKKLNHPNLVSLIEVLDDPSEDSLYMVLEMCKKGVVMKVGLEERADPYPDHVCRYWFRDLILGIEYLHAQGVVHRDIKPDNCLVTEDDVLKVVDFGVSEMFAKDSEMLTAKSAGSPAFLPPELCVARHGDVSGRAADIWSMGVTLYCLKYGRIPFEKTQIFELYEAIKTEDPDLSEEADEDFRDLMNRILEKDPQKRIKMRELRVALVPWDSGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK34</accession>
    <name>A0A1C1CK34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK34"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05292"/>
    <dbReference type="OrthoDB" id="4146015at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="71" mass="8320" checksum="D8D3C9B3FF4A4FF4" modified="2016-11-02" version="1">MSLNYGYLFSTKLVADDFGKYDNFVQDKKVFESIPNVNVSRSMVFEMAHVDVPEILLIYKRDPRLPKTWTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKE4</accession>
    <name>A0A1C1CKE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative RING and UBP finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_04593</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKE4"/>
    <dbReference type="STRING" id="86049.A0A1C1CKE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04593"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02923"/>
    <dbReference type="eggNOG" id="KOG0804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12717">
        <property type="entry name" value="RRM_ETP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034931">
        <property type="entry name" value="ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="330"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="366"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="685"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="771"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="537"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="612"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="773"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="806"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT48988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="820" mass="91644" checksum="15F4088E2A84B4B9" modified="2016-11-02" version="1">MPDYFFHVAIELFTESSFNPTQTEDLTPPSVLPFFKALRPFRNTPGRRRSRDHSFDQRRDSPLNCGRSQISAKPEQPHLEIPHSDSKDHRLDNIVLEGADMSTQPEGVVEVGKEENIIEKGIGSAISGHHMKGRFEAVNGNDGAEGWGIVHLYRDSEETAGLYKDSAYRSSDLWSDGVRNAPSARPHPPPRDEECTTLCILAVPSYMTPSDFLSWVGESTRNEVSHFRMVRTSRANRYMVLMKFKNGKRAREWQYEWNGKVFNSMEPETCHVVFLKSVELIQTSSLEQNSGLSSPTTSYPRMSNDPFIPASATTKPLAPRTPSLVELPTCPVCLERMDETTGLLTIPCQHVFHCTCLEKWSGGGCPVCRYTHDDFSSRLALSKSKSKTSAGEYEAYDGPLECEVCHTDTSLWQCLICGKIGCGRYEGKHAYAHFEETGHTFSMELESKRVWDYIGDAYVHRIIQDAAQPGEKLVELPGRRREPTALQGEEDIEMAKLDNIALEYTHLLTSQLESQRTYFEEVVQRAVDKASVATKQAERAVEESRLATERLRALESEHDLVAKGLVPDLEREKARLEKRSTKFEEMARTMSQKFQEEQAISRSLMERMEHHQTFQTKEIQRLKETIQRLEEENATKDLLMEGLREEHRDAMMQISAQRKLQEMVANGELAPEDLEGAVIEAGPAAAKKTLPVRGRRRAANTPGHGPGSSSQPQTSTSTAPQPPSSDELDKANASLLNTIFGCTTHGKDWNDDKVEEILSGCRAKLIGEGLLVPSTTTPPATQIDTEGSSDAELDGEPTGGGSKSKTTTKKKRGGKRAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKQ0</accession>
    <name>A0A1C1CKQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05242"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02825"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="138" mass="15838" checksum="2C8E6DB9ED99C264" modified="2016-11-02" version="1">MENEPPTCVSDAELDTLADLCLCVNHKNNRELIKKELEDRLTEACSLYESFQNLKTQFVEFRGSLCNKLSIEDNCSDHQISREVQKSIDNASRKDQQIRKLETDLASERSKTLLVNSAMEDLRNESRKSDIGEPYPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLF6</accession>
    <name>A0A1C1CLF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_04574</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLF6"/>
    <dbReference type="STRING" id="86049.A0A1C1CLF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04574"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03275"/>
    <dbReference type="eggNOG" id="KOG1967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="6">
        <location>
            <begin position="395"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="898" mass="99153" checksum="9675C064E6A057D6" modified="2016-11-02" version="1">MKDESLTGITDLVAGEKDPRNLMLVFSMLRVLMVEWDIQGHEQTMFDSVYAYFPITFRPPPNDPYGITAQDLKDRLRECLASTGALAPYTFPNMLDRLDSTSTTVKRDCLQVLSACADNYDPETLSQFSIPLWDAVKFEVLQAQEPELAEEALRVLKAIAACLSKSAKSIPNAPSSPLLQYLKPVNKECLEHLQEPAGRQAKASGDILKAVSSASIQAFEIVIGAIGPSLLTIYQASQGLVQQRAILEIANQLFEASIEVYGSWSSPSQKNPEGRENLVGQFKDSFVALYSQALMGTVKEEVSFRLTAATGLLLVSKMNSVLSDDEIGLLVQYFDDIVLKEESYGRDELKKKAMTALAEISRFKPVLISDITFPAFMARLPDSEDEARSGDYGSVLEGLAEISLERQLLETLMRRLLNKLELLFGASQPAPFPYTCAILGAVLYVLNRTVSKQSVSLEAYFDRMVVRISQRISQTTTGPLVNESVLDLLGRIMNLVVRHSSAESIQKTAENFYSLFAGASGAIEHERLAKVIEQPQRTILTTWLLAALPRTTQSSILAKDQVPRNINDLISVATTSQNPAVTQTLLAQVALYVNKHIQTPDLGFVEDILSQKLSALTDEPMDEAESRDLDIRLVFVLFKALILRLSPKTNEYLSRLVELLSPKRYPLSVSQKAALGFATILSPDDILSKENGAQIRLLVPQRVFQTLTPLIAEKFRTSESPLEKENYLIGLSGILASVPSEIVMPELPTLLPLLLQSLDIADQTVKIATLETLAVVISNNPSVLMHSGHIPSLVKRLIAVATATKSKAIKARSEKGGLPTVQENHPRSRRLATRCLTLMPKYISTSGSRANPLLPLKREVLHGLRNILDDTKRDVRKEAVDARAAWLRGVDDLDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM75</accession>
    <name>A0A1C1CM75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM75"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07569"/>
    <dbReference type="OrthoDB" id="4161720at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="237" mass="26737" checksum="E9F4559322922133" modified="2016-11-02" version="1">MGNTASRETPVPPQDGEESTHQNEEDNIVDVVATSIENSMESPPLDICTPAETPPPATRDRSTTEATLRDLLTAYQLSPPLEVSRFVGLCPYLCALLRWGWHASTADMDAFSILYPTFTAHLHAFETAQMERDLIAIPSYHQWFLEQPRDAYQQNILREQNLREIWRENRYESRRAQLCLTAIMNGNAPWSTAPWDPSPSSRVDDDGGAAEDETPPPDAQRSVQQSGSRKRKRPESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMP1</accession>
    <name>A0A1C1CMP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair and recombination protein RAD54B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RAD54B</name>
        <name evidence="7" type="ORF">CLCR_11332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMP1"/>
    <dbReference type="STRING" id="86049.A0A1C1CMP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11332"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08673"/>
    <dbReference type="eggNOG" id="KOG0390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000020">
        <property type="entry name" value="DNA repair and recombination protein RAD54B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="296"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="620"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="769"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="822"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="853"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT49749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="961" mass="106328" checksum="98FBBD960E29118B" modified="2016-11-02" version="1">MLSKPFKPLKIRQPNLNDDAATTESPPSKRRKLSPSDGQEDGSDLFRRPKCASKRPTSDISRQSLKQITNPSSPTQHDEETDTGGIDSYYSILWRLPTNKKNKTWTDDGVLAVRGGYATLYNNTGKSIGRIAFSSPLLPGSNLAIGGKEVEVDSCINKTEYLKYVSTSTEPAKEKPEMESGSSSANQQSKPSMQAQMKAQIQKQKAQTPKQAAPHPLRVSAFKPPIKETRVLAQTSGGTPTPRHDPAAPGALVFKRPPSPPDGRQTVDVVLDPCIAKKLRPHQREGVKFLYECAMGLKDFEGQGCILADEMGLGKTLTTISLLWTLLRQNPVFRDPPVVRKALVVCPVSLIRNWKREFKKWLGRDQLGVLEFDEKRTRLSDFDGRVFQVMIIGYERLRMVADDLAKSHSIDIVICDEGHRLKTMKNKAAQAIESLKTKRRIILSGTPIQNDLGEFFSMVNFVNDGVLGSQKGFIRDYEKPIMRSRQPDATADEIERGQEASEDMSRITSPFILRRTADILSDFLPPKTEYVLFCRPTPAQAKIYRNVIRSPMFHSALRSPDTAFQLITILKKLCNSPALMDPMSGNDDATPSSSLVALNDMLPDGFSRLYQNSVSSKIRLLDQLLQQIHRTTDEKVVVISNYTSTLNLIEQLARNSNYESLRLDGSVPAKKRQALVDQFNQSPPAKSFLFLLSARAGGVGLNLIGASRLVLFDVDWNPATDDQAVARIHRQGQKRHCKIYRFLIKGGLEERIWQRQVVKRALADSIMQGGARATSDSFDPSGRGKGSTSTFSQDELKDLFRLDESEGLRTHDLIECRCEGAGREAGDDSDIGPLPAGGDGNEDCDDESLVPVTRSSTSSPTITPGSSRRPSVTGKEAHSISPAQSESGHVAEKHELMQYRHINTSLLRQAEDANDDDDLKANILSAVEDACLEHVLKLDRDMVGGGGVSYVFKKVRGSQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN56</accession>
    <name>A0A1C1CN56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphatidate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_07184</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN56"/>
    <dbReference type="STRING" id="86049.A0A1C1CN56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07184"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08837"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000035">
        <property type="entry name" value="Putative Lipid phosphate phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF84">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="139"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT49919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="422" mass="46147" checksum="73053F84D94651F0" modified="2016-11-02" version="1">MGLFSRRTHDTAATGNTTNGHALRNEKRSRQPFDVDSGNFNRRPSFGQWLKFTWLDLLTMAAMGAIGLGVYEAKPAPSRSFPVTFSDGEIVYPDFAYPLRHEIVPIWLAALLASLIPIFVFLVMQFRIRSFWDVNNAVIGLLYALIGAAVFQVFIKWLIGGLRPHFLAVCDPDPALMGAHPGSGFESIMFQRNICRGDVDEIDDSLESMPSGHTTAAFAGFLFLYFYLNAKLKVFSNHHPAFWKLIATYAPVLGACLIGGALTIDEYHNWYDVLAGAVIGSVFAISSYRMVYASVWDFRFNHIPLTRHTPFSYGAGAAGAGGFETAVFTRQAGWGYEEHYGGAPFDAAHGLRGQAAGFNTGPMQHERYMHKPEGDVEANAGLHGAHGFTNGASSARNSDATMTGGTHYNSSSIGRKPVPTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNL3</accession>
    <name>A0A1C1CNL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07814"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="87" mass="9367" checksum="24AF8F61A5C6C6FC" modified="2016-11-02" version="1">MAMADFPLSVGTFLDPCAGLGIGSSVRRARLMCDRSFLRVADAAADFPPPFVDDDHGHDHDNGTYTAVRSPVVHTPSPYTLPLPEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNL9</accession>
    <name>A0A1C1CNL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase Rpc34 subunit family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_07096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNL9"/>
    <dbReference type="STRING" id="86049.A0A1C1CNL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07096"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08968"/>
    <dbReference type="eggNOG" id="KOG3233">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000116">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT50051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="468" mass="52164" checksum="1D7BABA997ED2E34" modified="2016-11-02" version="1">MAPSKKATATASPTPGPSSAPGGRNFVGDALYAWATENYDPGYVFSQQELLSAPVIPNADVTLLLPTVDYLVRKSLFRLHDRAGGGIGWELIDLEVAKNYAGLSRNEQIVLQVIEGAKNSGIWTKQIQTKTNIHQNTVEKVYKALESRNLIKQMKSVAHPQRKMYISASLIPSEDATGGSWFSEGVLDQGLIDTISDVIEAYVSTSSWQEVTLDEHEETSLGQKRRRPSDGFEEYGNDKVKLTKTIDGQNKVKPVKQHGPSKAYKPFEPGYLRYPTLRDITQYLLEVKVTASALPQNAIAQLLQVMIYDDRLFTLSRVAQATEVADDFTNNTVTMYRCFKTPLDLIEQRSIAKRKMSSDEKIRVAAYRHEELEALGPGGASEVPCMRCPVFDICGEGGPVNAVTCKYFTEWYDSLEQADKEKEPKEKKIKERDKTLVDKGKGKAQELPMANHDRGPSIEVELEEVEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPY8</accession>
    <name>A0A1C1CPY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ETFB</name>
        <name evidence="9" type="ORF">CLCR_07482</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="7">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPY8"/>
    <dbReference type="STRING" id="86049.A0A1C1CPY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07482"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05443"/>
    <dbReference type="eggNOG" id="KOG3180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="255" mass="27694" checksum="524CF4A067B88FC8" modified="2016-11-02" version="1">MSSKLRILVPVKRVIDYAVKPRVKSDRTGVETSGVKHSLNPFDELSIEEAVRLRERKSPVEEILAVSAGPAKCADTLRTAMAMGADRSIHVDVPEDKPLEPLGVAKLLKAIAEKEKSNLIILGKQAIDDDSGQTGQMLAGLLNWPQATQASKVAIDNDTVTVEREVDGGVETLKAKLPMIITTDLRLNEPRYASLPNIMKAKKKKLDKKSLGDYGVDATPRLKTVKVEEPPVRQGGGKVEDVDGMIAKLKEMGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ80</accession>
    <name>A0A1C1CQ80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ80"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ80"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06942"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05393"/>
    <dbReference type="eggNOG" id="ENOG502T3P2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4161771at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="589" mass="64469" checksum="6DE24979D9BB190F" modified="2016-11-02" version="1">MDADKAPNDGVRDPSYVVTEPLCTTLDDTSGSPLPGPSLGDVQSIDQASVTPGVSRQERASANLRKRSTKEDVMFVTNKRQKNSSKVREAAIANLRQGCRKSAGGLSADMPDTGSPKEGRYPLRNLTNPGPQEEAGSERVSTDDATTPSAVNQDGFTEVERAMSLGNSATPNPETASKANPVQPISRKHTLAPNTHRRTRSLAKDKQPSRSVVVNQVDEKDDSADPMECEASAHDPAPQAPYLATPYEQRAASEAAGETMRENDANGGGDQASAMRLYDIENTASELPDSEDEFLPEDSPSKEHDEDHVQPRQTTHSRPSNSRRGSRISRSAESTTIAASNMSASDAQSPSTLGTRGRLSPSASPITTPPESRGVSRPRIVSKKTADVQEDDARAIEKLKAMGVMFESDSEDEDEEVECEDDFQPLPPPRVDPLWQRPERSRNLFDIDPSLDVTDPANRLAAAGILPSSTRPSKKKLMGNLLLYQCAERKKRFGNPHQEVRRYPKQALVTTDVQLGIDFEAPGDPQVKTEKATMTFREFLGAPKNPVIEARKDQVVFREKEQMQQVAGRNRRTRRKMESDVFPFVEGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ99</accession>
    <name>A0A1C1CQ99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SMG7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ99"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ99"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06642"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05348"/>
    <dbReference type="eggNOG" id="KOG2162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF36">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="3">
        <location>
            <begin position="59"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="2">
        <location>
            <begin position="189"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="804" mass="89865" checksum="DAB7C857D273FDB3" modified="2016-11-02" version="1">MEDIALRASKNVDRAENDITLALSRSDTKHENLEPLLAKLRAACQDYIFLDFAAAAKKQVEARLWAAHSKVNSRFRPLMARFREGDGQKLKVERRKAEKLYLLFIKSSQAFYRGYIQRLASNFKGIPEILALAHGMELDTLSADTPQPVDAGLKAKLVDSCYSALVQCGDLSRYRETELKAHLRNWGPAVGYYNKASVLKPADGRAYNQLAVIALSDQDHLRAVYHLYQAICVEMPFPQARGNLELEFKKLRVKANQGKPIAGNSDVFKGNPYLYERFLLFHARCWEENPPEQEEQQMEILRLIADQIRQQPEATILRKFSLINIAAEKSAAEKVDGDPSAFRSFEILQSFNVKTFTLLLKLVLDELQQLAGNVDLPATNPLAEVPPVTRRTLSHLRLYSGWLLTTVQYLLANLGLASQMQQLWRLYVGALNLLLQLFPPSDAEFEYLLKEDAETLGFSAFSQFVRDKRFRRSSQFKPIYTEASFGPAIPNNEMLFRIKEFIRDAMFLFKSRFVYLGDEDKPAQAEKAPVASAAEAFTGRQASVLSANTEYAIMNGGIVRQVPSQHEIVPDAEGSMASRMENMVDDLTRPGVPSRESNRSSIAHDSSAAPMKTPLAQTFADWGNPPSQPATFTARDLVQRMQHSSSSASQPSPRAQANNIAPLPSIWNTPFAPRPGETPESSPRPSSAHRFTHPPSVPQNLNSSAEFHTNLVHLQEEIQTRTSPPSSFQPTMSSHYDTPTNLTSWIRAHDQTQPPSSPWKSPFISAVPVHQTPVPTKHTNASPYGAIGESRPRSSRTPNTGQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR10</accession>
    <name>A0A1C1CR10_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose/galactose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gluP</name>
        <name evidence="4" type="ORF">CLCR_08481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR10"/>
    <dbReference type="STRING" id="86049.A0A1C1CR10"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08481"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09561"/>
    <dbReference type="eggNOG" id="ENOG502QPVD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF5">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="458" mass="49744" checksum="7C2AE306BC7FBE6E" modified="2016-11-02" version="1">MADTVERTPSNADAMASQRRKSVANKGLTGASALTVRQSIFPITLVTVLFFLWGFAYGLLDVLNAKFQNSLNITAAKAGGLQGSYFGAYFIGPLTYSGALMFWPSAVYKSFAGFCGSLFIVGSGLSTLETSANPFIATCGPPRLSEFRLELSQSFQAIGSVVAPLLASRVFFKDTNSTDLSHVQWTYVGIAAFVFLLAVVFFFSPLPEVTDADMALQAEQCSDLTGYQEKPLSKQYKLFFGVAAQFTYVGAQVAVASQFIKYTEESAKVSSAVASDRYAIGQALFAIGRFAAAGMFMFIKPRLVLLAFMTMIMVFIALSMGVWGEGGVACLSLVLFFESCIFPTIFTLSIRGLGRHTKRGSSWIVASVCGGALFPALTGLAADKMTYHKAMCVPLVGFFVSFVFPIYLNTVCKKELDGFRETKIGYVDERRGTIIGDIKDIETFEAMQKKHSVNVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR59</accession>
    <name>A0A1C1CR59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADPH-dependent 1-acyldihydroxyacetone phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ayr1</name>
        <name evidence="6" type="ORF">CLCR_08862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR59"/>
    <dbReference type="STRING" id="86049.A0A1C1CR59"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08862"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09633"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000261">
        <property type="entry name" value="NADPH-dependent 1-acyldihydroxyacetone phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF15">
        <property type="entry name" value="CHAIN DEHYDROGENASE_REDUCTASE (AYR1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="298" mass="33140" checksum="2F1E6E6DDF27B786" modified="2016-11-02" version="1">MAAEHHRKTVLITGCSPGGIGHALALAFHARGLRVFATARTTTQISDLSLQGIETLPLVVDDDESILSCFRDVEQLTEGRGLDYLVNNAGVSYIMPALDVDLDEARRIFNVNVFAVMRLCQVFAPLLMTAHGTIVMIGSLAGVIPYVFGSVYNSSKAALHAYANTLRVELAPFGVKVITVLAGGVKSNINSHVKRVLPRDSVYSTLEDSFVRRQVHSQESAMPNVAFAESVVNQVLPPSGPWRPWSWLWRDARRRWIWEGSKSWLVYSLAGGYTWTAFFDWWMTRAFQLSRLKKGKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS76</accession>
    <name>A0A1C1CS76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS76"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08039"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06733"/>
    <dbReference type="OrthoDB" id="4149219at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="763"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="820" mass="90314" checksum="BB8BDBF6995F0910" modified="2016-11-02" version="1">MAAFSTPAYRTLSDGQGFPPGKVDLFEFVLPSKQMPFDVLLLLALLPLKLHVVGIDLSFLSRSFYLWQIHQDPVQQQQTSHGAFKSTRGQVLHRGYFGFSCWSLIVCWRLRIQTQVSRLCQALGKHEDRGLLAVQWFSNPHLPISPPLRMHTKQTTHRPLPVALSESSDFHRQGRSENIDAKLGDGQESAQLDHIPNAEGKHQNKGSDRHAETFVGAIPGPKTYPSRPLAYRTRGPTPLKPPASVLTPTQNRALRAEAPQASTQHAFPLPCQKSKSTRERGNQLKTSFSSSKRQREAAPENLTNARATGDERRGQHVRIQPDYKAMGAHTASVAPKQFEPTESKPSFNTKPAENGRPTGEAAKRKRGEERPPSHSVAAAPKRNTHHGKREPVEHSGDEGGSGSEQQPPNRNSHNGSKSNKSATGLSFRCPMAAANHNGEAGRNCKEWHNASIAAVTRHAQKDAGAHSAKWEQIRDLSSTKLAPKERWRQYFLIFNDGQEDAEMDRPYWGGTNTDDTIDLLFRCAKASLEPDGGSPTAPVRLLLEHQSLLRRREQRDSHIRARADAMRARATQMEQAELLQSQRQFDEDLARLLAQVGDVSLVPGADQPDIPPTAALPTDSQDLQGLAWPTTPMQRTTSGQSAMNAAYGTPFNELATNPGALTLPAQSPFPSSGQNPAIGRPNSLATEPQSLTAFIENVSVVVDPNTDPTTRQQVQSWQNSHYRQSQTLRPPQLDRTRPSYLVPGHLRRNAIGLPVSSNSTQRLTPTSSSTTNSLPAPRYVAPTFASDDNADIYMGYSGADAPAYDYGGEDPSYSHLPRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT40</accession>
    <name>A0A1C1CT40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_08064</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT40"/>
    <dbReference type="STRING" id="86049.A0A1C1CT40"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08064"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06445"/>
    <dbReference type="eggNOG" id="ENOG502QQCV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5344325at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="187"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="609"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="611"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT51656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="747" mass="84191" checksum="74411E2FD4977583" modified="2016-11-02" version="1">MESRPYSAAASGEQMRKKRMRITFSCTNCRHSKQKVSSPLSLIAYIGSDANKCNRESPCMTCVLRGKQDSCTYGDAISGVKRSHLSAKGPNTNGFSKQPEVEAHEYSPTNGGESRSPDLAAYGYSSVNVHNSLGILQKLENLEVGGTRKSPPRKQRKITLCRPALDIYRAVLKQLPCPSCVRHLVAVFFNEVNWQYTILDRNYFIPKLEEYYQHYPLQPPSPPADTTVSSEKLIFSALIFQVLAYALQFIPARYSENLHPPCLKDIDEDGDGVSEDATMRLLSLLPKDVINLDYIAAQILRTAWLKNRGLIAEAWLVVAQAAINAQEMGLHRDDGKLYASDAESAIEELWEVVLRRRLMLNLYLWDSQMGMVLGKPLNFKPNDYTIIVPTDCEIPRNRTSMAPFQRAESDKPNTFTVRLLEYHIHKYLPQVRELEAQGPYPRDYGKVERLHQIALDYIASIPPIYRFENADRSYDVECPHLASQREFLCATVWLFVLMLHRTYIFSIAKSRTEILKAGIEMLNAQQRFFLTLEPHHYRMFTLAYLTVEPCVSMLAVLIAFPCENADLVAEAFRCIKESLSRVNTIRRTNRVAGQGADVIHNLLLRAEKNRPSPSLGSKPSTSPSEGRSSEVLMTPSSHGAGPFYPMAEQPLMFANNTTFAEMADWNMQFQQTSSMAPAPVSSGYTFNDTPFRPVADLTYNDVALAMSEEGFSAESGSERMSTEMPQQFRGEFGEGSFWSFVNRGSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTD8</accession>
    <name>A0A1C1CTD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD binding domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_11372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTD8"/>
    <dbReference type="STRING" id="86049.A0A1C1CTD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11372"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05223"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF7">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="5">
        <location>
            <begin position="8"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="5">
        <location>
            <begin position="223"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT51763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="461" mass="49308" checksum="CE0F11CDAB7B09BF" modified="2016-11-02" version="1">MSLPDYCDVLVVGSGNAGFSAALAAKESGAQSVLVIDKCPESWAGGNSYFTAGAYRTVHAGTSDLLPLVNNVDAALAQKIDIEPYTISHFQSDMHRVCAGRSDPALATTLVENSNAAIKWLAKNGIRFQLSFNRQAYEVDGRFKFWGGLALKTEDGGKGLISDFKKAARRVGVTVFYSTALKQLIAPGGVVTGVAGNWSGCHSVAWDADAPFHAGDQATSNEFTKSGYPLGLMLNTKGERFVDEGVDLRNYTYAKFGRAILGQPSQAAYQVWDAKAIPWLREEEYRPERVKRIIASSIEELARKLAADEGLEDASTFVTTLADYNEAVYAHRKENPGCKWDPAIRDGLSTQSRTHQLALAKSNWALPLDQAPFMAVKVTCGITFTFGGLSVVPETAQVVSATTDKGIPRLYCVGEMLGGLFFENYPGGSGLTSGAVFGRKAGAAAAADAAQQAGRFARASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTF6</accession>
    <name>A0A1C1CTF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ALDH1</name>
        <name evidence="8" type="ORF">CLCR_08175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTF6"/>
    <dbReference type="STRING" id="86049.A0A1C1CTF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08175"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06351"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="470"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="564" mass="60578" checksum="F177687D40055006" modified="2016-11-02" version="1">MKPSTIETRLFINNEFVESKTGKTFKISNPATDQEICDVHEASKEDVDLAVNAAEAAFPHWSSLAAHERAMCMFKFAQLVQRDAQQLAELDSVCMGKPVELLKKMDIPALVGVFNYFAGSGYHIVGESSLSSPNFLNVSVRQPYGVVGLIIPWNVPMIMFAFKVAPALICGNTVVLKSSEKAPLSSLKLAGLIKEAGFPPGVVNVVSGFGDPTGTAIGMHMKIRKISFTGSVATGRKILRMAADSNLKNVSLELGGKSPAIIFGDADLDAAARYTHYSINHNSGQHCQANSRVLVQEGVADAYIDRLKTLMAKVTIGDPADPATFQGPQSDHAQLAHIQRLVDEGAKDGGTLVYGGKRHGTTGAFIEPTILKNVPTQSAAYREEIFGPVVIVNTFKDEADVLAEANCTDFGLFCKCPPRPVAVAPLRGHAFALWPSLHPTTSVAGNSKKRDEGGLVFTSHLSPTYKLTKTNLPLPASVYTSNFDRAVRVAKALEAGAVGINCSVPVRAVDMPIGGWKQSGMGKELSLHGLNTYTELKTIFMKYNADPTSMAVNTWHSGQMQNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTT3</accession>
    <name>A0A1C1CTT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Guanine nucleotide-binding protein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CGA1</name>
        <name evidence="12" type="ORF">CLCR_08639</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTT3"/>
    <dbReference type="STRING" id="86049.A0A1C1CTT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08639"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06216"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003800">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000002">
        <property type="entry name" value="guanine nucleotide-binding protein G(Q) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="176"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="276"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT51911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="346" mass="39218" checksum="2AFE99CCB7B4F1B4" modified="2016-11-02" version="1">MGCTFTKEDDDGRAEHDQIEKELKLDHRSRTREIKILMLGTGDSGKSTVLKQLKLINGGGYSDEDRVFFKGVIFTNVVQSMQAVLEAMDAFGIPFASPATANPHASLIFSQRQQITAPELSPAVYSAVKTLWDDAGVRACFSRCSEFQVCDSAQYYFDEIDRIAADSFVPNDQDILRSRQKTTGVAEFSFTSTSTSSSEDTVYRIIDVGGQRSERKKWMHHFEDVDLVLFLVALSEYDQALYEDGSVNRLQEALDLFHSICQSQWFRRTAVQLVFNKTDLFREKLKHSPLEAYFPDFQGGADYAAAREYIANRFISMGKTRYPDNYLCATDTAQVRLLMGRIIDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU95</accession>
    <name>A0A1C1CU95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_08178</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU95"/>
    <dbReference type="STRING" id="86049.A0A1C1CU95"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08178"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06072"/>
    <dbReference type="eggNOG" id="ENOG502RSRA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5319458at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G12570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="645"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT52063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="677" mass="75518" checksum="0FB8E1496C53EF39" modified="2016-11-02" version="1">MTKPESVEALLNPSLRVSRPVAACARCRSAKIKCDGKLPACSACERSGKATSCTSANDEFARGKERSYVAALEAAAQRLQKKIDMARVEAAGHQAASGASSAGRPQQRRKISGARRREASDVDELVSDFGFLTVNATSRDFHGFTSTMSFAKLLLSAAARDELPPLEMRGLPPRYAITPMINQYLENIFVLFPFFSETDLMASLSRIYNDSAAASSTVTPLDVWYVRLILATVHAANSQRKGDENDSTALQHMSAARGLAGYVLHPGSIAGVQALLLLVQYSLVDPAHYDSWYLVGMAARLVVDLGLHCEPAPETRISKSTLDLRRRIFHCTYAFDRLVSMSLDRAFSFTDDSASEVPLPESVADPSPSQVFQRLLKPSLYLFDIRRVQSAFYQTTRWSSRSQWPLATAATYASTVSNDIHAWYSTIPPTLSQRHLMLFNLERLYSHILVVSPNQRVPASSMTDLNKELVFEYSAQYADLLQPIAQDISWHAYLTYADICRAKYVGQKFVEVMWSDFDRLIKTTHAVREGSPLANNVPLDNGQRATICLRKIIEILDFARHRWAMPEMRERFEQESAVLFSRLKSRQMEFGASQYSTNPGLVGPNTGYGSGSNQYAYDGPVLTQLPSPPINQDPVRPDVQQQRMLTPPEEYHMQPGPYPMPQGTLPRRSYEFHGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUA8</accession>
    <name>A0A1C1CUA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pre-mRNA-processing ATP-dependent RNA helicase PRP5</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Pre-mRNA-processing ATP-dependent RNA helicase prp5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PRP5</name>
        <name evidence="20" type="ORF">CLCR_07916</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUA8"/>
    <dbReference type="STRING" id="86049.A0A1C1CUA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07916"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06049"/>
    <dbReference type="eggNOG" id="KOG0334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990446">
        <property type="term" value="F:U1 snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990447">
        <property type="term" value="F:U2 snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903241">
        <property type="term" value="P:U2-type prespliceosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17953">
        <property type="entry name" value="DEADc_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22474">
        <property type="entry name" value="KH-I_PRP5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="565"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="596"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="801"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="299"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="965"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1023"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="15">
        <location>
            <begin position="565"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="52"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="129"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="974"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCT52091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1206" mass="133268" checksum="877D0F32941D254D" modified="2016-11-02" version="1">MARHGDTRSPSPAGSSYSSRTRDRYEKSRREDDRDRDRDRDRTQRRRHSRSRSPEAYRLPEQRRHRDRDRERDRDRDRDSYRRRDRSLDRRPPSRKEDDYYASSRRDRDRDRSRDRRRSRDRDHRRRSRDRDGRSRRDDSRPRDGRLRNESTESGKRKRDDDRDGTSRRDSGNGSREVSKPSTPTAQTAEEQKAARLAKLEAWKKKQAEEQAKKQRELEAAGGARSILQEIDRKAGILPIATSPQSPVSAAAGPESTPPAPAPYAGKFDPKAIVKKAQHATTTNKVLGADIAAPALTNGALKASQSSPKSPTNGVPTTKALKAKGNLGKFGLGSKAVVDSDAPKKGLDFADDEDTKKKLERLPNLALEEGGAADNGEMDEVDDEGDNDVDMQGEDGDEDVEAMAAARAAAEQRSKAERGEDTAMSDAPTAVAVNGDAEEEEVDPLEAFMQGLQPVEAKKSFNQKSKSKLRQQEPEAMFGDDEVDMTAVDDENPDNILSLASANAKKKKKDIPMVNHEKVQYQPFRRNFYSEPVEMADWTEEDVATLRMELDNIKVRGVDVPKPVQKWAQCGLGVQVLDVIQKLGYEAPTSIQAQAIPAIMSGRDVIGVAKTGSGKTIAFLLPMFRHIKDQRPLEALDGPIGLILSPTRELATQIHKECKPFIKALGLRAVCAYGGAPIKDQIADLKRGAEIVVCTPGRMIDLLAANSGRVTNLKRVTYVVLDEADRMFDMGFEPQVMKILSNIRPDRQTVLFSATFPRQMEALARKTLTKPVEIVVGGRSVVAPEITQIVEVREENTKFVRLLELLGKLYEDDKNEDDRVLVFVDRQESADGLLRDLMKKGYPCMSIHGGKDQIDRDSTIDDFKAGVVPILIATSVAARGLDVKQLKLVVNYDAPNHLEDYVHRAGRTGRAGNTGTAVTFLTEEQDRYAVDIAKALRQSGQPVPEAVQKLVDGFMEKVKAGKEKAGASGFGGKGLERLDQERDAAKARERKTFKTGDEGEEQEEKEEAKDIKVGDDIFAKAASGVKAHDARPSTPGVPKGIDLDGKIVVHKTERPEPAAGAKVSTDPQNRLDKVAAAVNAINQKLSKAGVMRSGVPIDNKGPDAGAFHATLEINDFPQKARWAVTNRTNVAKILESTGTSITTKGSFYPAGKEPGPNENPKLYILVEGDTEVVVHDAMRELMRLLKEGTMSASETVERPSGRYSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUL5</accession>
    <name>A0A1C1CUL5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">swc4</name>
        <name evidence="10" type="ORF">CLCR_08042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUL5"/>
    <dbReference type="STRING" id="86049.A0A1C1CUL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08042"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05972"/>
    <dbReference type="eggNOG" id="KOG2656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DAMP1 SANT/Myb-like" evidence="9">
        <location>
            <begin position="139"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="357"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="527"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="570"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="608"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="687"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="714"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="739"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="763"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="793"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT52183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="814" mass="90402" checksum="F9EF04E8CAD64F25" modified="2016-11-02" version="1">MASTSDIRDIMNLGQAGPRQPAPKKKKTSEPQPRVTGVRREVQALMGDSVPPIAIVEQRSYKSRPSISQKLFKPRHWDERPFQHGGRTDGLVLRHWKRSIPGSNGRAPAVTTESADVEMADDAKTAPVAQELAFEEEYPSHKWNVKVEVPSYTDEQYDRMLKSDDWTRQETDYLMELCRDYDLRWIIIADRYTPEEIPSSTPAPTSVEPNGTEVAMKQHYPPRTVESLKQRYYSIAAKMMEQVTPASTMTAAEFQLWEKMRSFDAKTETMRKAMAEKLFERTKDEADEERILLEELHRITKNEDDFIKMRRDLYARLEPVAPLRRSGNGEEQSTAMYQTSGGLSMLLQSLLAKEKRLKRPTMPDGGQGSTSATPTDARAEKGRQSSHYSRRDTLDTQATNDEPQKKSSTSQASNVRILAPADAARFGVSHPQERLTSGVQFRHEKINRLTMAKSQTQTTKIQAALTELGIPPRLLMPTERVCREFERLVGEINILLDCRKVAEKVASEVKILEEQRRIRLGLPKEGEENVPAAGVGNAGPPEVKSFPNTTDAMEVDDSQVGDESKVDESLAVDEDDQDAEAEDDEPARAGAERNEDDAQDESAIQVDAQEDGDADAEANDDASAEPVDDEDEEDQDERDEEITGLDNDEDQDEDAEDDDDDAAGGRLNADSDEDEEEEAGASPPQDTDAEEDNADDSEAEDDAEPQAETGSHNDEDEAADIDDGDSEAEAEAEAAHEVEDSEDEDQDQDDDEDPAPIPAAAAEESDLEGEDQPDGEDEPEAVPAVRAHKRSASVISEASRAGSNRSGMGRKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV56</accession>
    <name>A0A1C1CV56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV56"/>
    <dbReference type="STRING" id="86049.A0A1C1CV56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11047"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03795"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="107" mass="12263" checksum="4837F3518DBA4855" modified="2016-11-02" version="1">MDVDRDSPPRWSQTPPALKAPVRVRPPRISQPLKVNKDQRKLDEFYTKFLGRDGDKMLSEETKWLAVTNKSFDAGRRGFNDRLAFFGRSNRSLSNGRVLIEIDQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVC0</accession>
    <name>A0A1C1CVC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVC0"/>
    <dbReference type="STRING" id="86049.A0A1C1CVC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10138"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03842"/>
    <dbReference type="eggNOG" id="ENOG502SMT3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="77"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="487" mass="56141" checksum="30EDAB600AE1895F" modified="2016-11-02" version="1">MEQAVPLLHETYLDNVPETYPHPLPDDLSIPTRRQLRPEQWKWIQFKHMLKSCLSGLLPTYMHRRETAGRKELHPTAYLDALRGYAALIVFFYHSFPLPSIWVFQNLFFFRVLFRGGPGMVAIFFVISGYVLSNRMLVMTHNRDPAKLLDCLASSTFRRWLRLYGSTGVATFVAMAFTQLGWFKPHATERKETLHGQLWDWFNDWLYSSDPFAPLQGWIHGGAFGSRYLYQMWTIPVEYRGSMVVFAFCAASCKLSTRSRWIALWTVVLLAYYWRAVYVAEFLAGTFIADLALLRHPERVIGKVLPQAETSEKQPTPLPGWWQAHGVASKLGCIIMCTAGLFLLSQPDDPDTNPEIPSPWPSLLRLVPSWYGDAMYTFWVSIGAMLLVLALDNYPALQVPFNWSFSQYLGDLSFGIYCMHIIVLESLFKPILNPWREKTLGQGYLACFAIEAVATIGVLWMADQFTRADKMVVRSGRWLQRRTFQKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVK7</accession>
    <name>A0A1C1CVK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII28-like protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_10457</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVK7"/>
    <dbReference type="STRING" id="86049.A0A1C1CVK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10457"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03957"/>
    <dbReference type="eggNOG" id="KOG3219">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="174"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="355" mass="39532" checksum="AEC673005381B594" modified="2016-11-02" version="1">MASSPPASFPASLPNPKKRASMSSQTSAQGTSKRPKLHPLRQTSFPAQDASGRYGSAVTSARSETGSVANSLLSGLSGKVKGRGRGRPRKSAQLDLDEVRSTYQIPGETTSQVDGSERAAHRGTKSVVSARSGAAEQEEDDEGDIDELVENMDEQERRQAEEEEIRQEQRRERLADTLDPDQYARYNQWRALSLNNSTVKRLVNSIVSQSVTTAPLQAIRIYGKWFVGEIVERAREVQIEWAKAYEDTRMEERERREQELQVLEEKQKEANDADPQSRLIARDIERLKREVKDYIPNPHKGGLLPDHLREALRRYKNDGEGGGVGFQGLSHGLLGVTGPAAWRVGDGASGRRLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW05</accession>
    <name>A0A1C1CW05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW05"/>
    <dbReference type="STRING" id="86049.A0A1C1CW05"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10103"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04003"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="262"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="494" mass="54489" checksum="1933C1BF77FD919B" modified="2016-11-02" version="1">MENLPLPLSSPSSVLTPGSDIKPIIDRYSTKVRLHNPVGFIELTSQQDIVPIDPTLTSLTRVLRNGGTLDQAGWSARSLWLTSISLPELGAFDGHKAYLLAGGEYQGPLKEDLEEEPNDAKSEAIFAVSHGLLYAGCYAEAYLMISLKTNFLEAHGDREKEKLIDLKLAAGAAFEQAIKQHSEQYAQATKQGIQQHSALSDELPNFMLVPAIRDGRVRVTKYPLIPEELYGLQAAAFGRLNFELKILCKVPGSCVIQKKAPLSNEGSSTEEPGSRTGYGIQVTRDIPRGALLFSERTELYSHTHSDDLRPCKNCVLDVPENRQADGTYEYTTSFCSNSCARKFARFVHVPEELFRNVLQDTVQWVNQNPGQHPLSAPSIATLNADYGGAMYVSYDRHIAAAIDELQRQDIDVYSGATWDGCVVMDILARVQNNSRAFNVDEEASFVALTRLFSLINDGPANVTFTWRTYGAAATVEVTANRDLRKGEELFIGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW24</accession>
    <name>A0A1C1CW24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW24"/>
    <dbReference type="STRING" id="86049.A0A1C1CW24"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09632"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04094"/>
    <dbReference type="eggNOG" id="ENOG502SPGI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="812" mass="91531" checksum="A1F5D8279B164F77" modified="2016-11-02" version="1">MSDNPPPKKKSRFFSNGMSVVDNILRPLKQQARKDGEGNGSAEAEANDPPRDGTPSAEEGSSLLSNIRPVAPSTMPAQTRTPNETPATGSAPGPPSAFLPKEHQDHRQSHPPPRHAPDSEAETEVESIADRREDEEDCDASDEENTKPSLHIQGQRHQRRQAIYGAEALLPQGSKTGGQQTSQPPSFIYNPRSVPAQGPILTGPSALAPPGNSYTFSGVPTNPNASTTGGQFAFNFRLTKDLPIPSTIQQPAYNQYQHPIGSGLARIAHQAVHADTGPLNQHGQQDLTTPKQPFQTSVLKAPYVDMDRDEHGRRLRDYVPRPTAHHGICHSSNTVAPHLRATDLDSLIPEHMYTSPNRVERAQQFARINLKRKRADAILPPASYVYQHTGSPDFNIFHGLLLYPELCFALAAHLPVKDLISLYAISKDFHVILDTRFTTVMLRQAVSKAPDSARTFMFRSYAHLCRSDPAARIAHPNAQLAEQGTPRKIPSFRWLKMVLHREKVIHELMTVFAEDGIPLPARCALALKRLWFMLDIPDNARRIGFVHNKTLMTDLDLYFCACFITKLDMRLNDPISGEKRDGMRKLLLAQRSFTRILRVLKREVWTNRFDVLREWVRVKHVVVEEDEAGLDMFGVPASEIGRGRLEYWGLKTEEDVGRKLHGLLRPDQLIVREAIKRGMRFEKHYLRFLLYGYVRPDTLEDYAPRTYGRRIREIQDDEYEVDDLVGGVAALGMGDEGFDPLLDLGQPRETSPYTIVKEETSKAEVAMRQREEEFLDKCISWWEEERRAMQPLKQHAARGIVRDGANYCLQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW56</accession>
    <name>A0A1C1CW56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_10182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW56"/>
    <dbReference type="STRING" id="86049.A0A1C1CW56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10182"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04058"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF242">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="65"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT52675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="432" mass="47915" checksum="17304ABA5BA884A2" modified="2016-11-02" version="1">MGEIGAGLQTLANSSRVLISWGMGEQLSKCATTPRLCNMIGWRGETISTWDIHKSTREEWGSPYWDLHRVSLHQCLWDRAVELGAEVRADSRVTDVRVAADGSSATVILRQGEKRKRVSMNADLVVGADGIRSHCRDLLVGRDDPPAKSGDMAYRVLLNTDDMLKDPELRDFVLDPQVNYWIGPECHVVSYVLRGGKQFNMVLLVPDDLPEDVVTQEGNVESMQALFKDWDPSLGSVKKWRLCTRTPTPSSPSWYHPSGTFVLLGDSVHATLPYLASGAGMAIEDASVLGLCLSRISSGATAQEKLRALKVYEMCRKPRTRRVVEKAYESQYLYHLPDGPEQRERDGKMKAFEDAYRIQGNGAVPSGLKQGDDPFAWRSGGVGKWLFEYDCELDVERCWTLLQAEEGAAAARSASRADPKKLGLGLVVTARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWG8</accession>
    <name>A0A1C1CWG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10761"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04233"/>
    <dbReference type="eggNOG" id="ENOG502TFCC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="209" mass="23508" checksum="A78DDCF1F4162532" modified="2016-11-02" version="1">MSHPSTPLPPHTGPSLFKAAEPATRVSRYLAIARGFYMYLCPGKSLDEAAQFQSQSTQLYDAAPLIPNLPNEAAFHELPARLYDFDYAQLRNTTLECMGTIGTDNKTAIVTLFEIATFEALPYESVLPPDNADEDGRWAHSVSRKRDWDIYRVKTSGGTPPICDGTRFMAEKEYTAEYWFYYAGGEDLWTPTDVKREESTIAQDMPAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWM0</accession>
    <name>A0A1C1CWM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Group II pyridoxal-5-phosphate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_09930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWM0"/>
    <dbReference type="STRING" id="86049.A0A1C1CWM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09930"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04196"/>
    <dbReference type="eggNOG" id="KOG0629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF8">
        <property type="entry name" value="CYSTEINE SULFINIC ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT52855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="591" mass="63484" checksum="4962B0D81B417C15" modified="2016-11-02" version="1">MADQPFEDSTDGPESNGHDVGALNGTKASSHSSDFFFSRADELQNLLVSVVARLVPFVQQADVERRAHRDHQQVPASCLVDSHTPSDLLAILGSSGALSLPDLGTGQAGLVETLSAILKYSVNPSAPGFLDKLYAAPLPPGIVAELILAVLNTNLHVYQVSPVLSLVETHVTRTLAHMFGFTGPRAGGINVQGGSASNMTSIVVARNTLFPETKRRGNHATGRQLVMFTSEHGHYSIEKAAQQCGFGSDSVVSVPVDPLTGEMDPLALEALIVREKSHGKTPFYVNATAGTTVLGSFDPFGPIADVARRHGLWMHIDGAWGGSFVFSDTLRSRTLRGCELADSIAINPHKMMGVPVTCSFLLLKDLKNAHMANTLRAGYLFHDKAGDDADSAENTVSVTNGEHPDNDDDWTPPDDLADLTLQCGRRGDSLKLFLSWQYYGTAGYATKVENAYSVACYMADLVDKHPNLLLVSTNPPPCLQICFYFAPGKKMVHAPSDIIPRTNGGSSHNEDTKSQAAARFGKRNSAVTSRIAHALISRGFMVDYAPALSHQVDKGAFFRVVVNISTTRETVERLVQEIDLAGRPATIPNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX62</accession>
    <name>A0A1C1CX62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ctr4</name>
        <name evidence="7" type="ORF">CLCR_10764</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX62"/>
    <dbReference type="STRING" id="86049.A0A1C1CX62"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10764"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00133"/>
    <dbReference type="eggNOG" id="KOG3386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF73">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0187">Copper transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT53163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="215" mass="23492" checksum="168474222EFB41E1" modified="2016-11-02" version="1">MSSMMMMSTATPTSQTSMMTSVSSSVSASDNMSMAGMEGTTCKISMTWNWYTVGACFISQSWQVTTRDMFAGCCIGVILLVMSLELLRRLQREYDGWCGRMDRKAFVAISAGSEDANSSSSELGAGPAGKAHSVAVAVTTSTPMSERAPLPRRRIAQWILVQRHVIRSLGHMVQFGLAYFIMLLAMYYNGYIIISILIGAFLGALVFNWDQVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXB5</accession>
    <name>A0A1C1CXB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10834"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="104" mass="11703" checksum="61933E120FDD581B" modified="2016-11-02" version="1">MDWLQPPGQRQVRTNAGVPGQDKVQQQKFQQSTRVCLLQFPSYSILFSKRRTPQGDTSVKDRENPQIKSPSAQRTPSPPAEIAEAESGKGESIFCARRCLHHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXV3</accession>
    <name>A0A1C1CXV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXV3"/>
    <dbReference type="STRING" id="86049.A0A1C1CXV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10833"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00201"/>
    <dbReference type="eggNOG" id="ENOG502RZ3K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9998495at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="44"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="191" mass="21287" checksum="A30F993C30425E57" modified="2016-11-02" version="1">MRLDYVPNPPTNLSAEDQEVLERVKARRGAMGLIPLDLTLLHAPKIADGWNALLGAVRTKNSLPDDIREIAICRPALINKAWFEWNAHAPILLKSAGFTEEKLAVVKQLRPTEKGALDDRQWAVLRYADAMTRDVSVPQSLFDEVKAQGFNEQEIVELTATVASYNLVSRFLVALDVGEQNDKAPDWASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXY0</accession>
    <name>A0A1C1CXY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone deacetylation protein Rxt3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXY0"/>
    <dbReference type="STRING" id="86049.A0A1C1CXY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09539"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00304"/>
    <dbReference type="eggNOG" id="ENOG502QX51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="922" mass="100577" checksum="36158A0EF928987D" modified="2016-11-02" version="1">MAMPGHSPPFNGPSSPPRAFTGYPEHQQPPLMFGPARTMLPPSPQHFPPPRFSQPPGQQNSGATVATNGPAAPHKRPGSSMSISSMLGAEPERPLHDPFHIHSQPARPQSGPFSHHGPSMSLGAVMSPPHYSGKTTTTEYSYKPRSKTPDRAAGQSLGVRAQRSSSGSMTQRPGPFYDPAPRSQPTQPNTFHESKYTPPFGPVTGHRDEFEDRARRTSIGGILQRPESQPQPARMSPSFPTSHPLSRPESIPPSLAPVDRPAQQIMHGQDPPRSNGGTSHYDTRPPGFSTLSRVPPSAPPPMSAPQDRPLTQSLSPELRRPHLNGGEGRLAGILNQQGDPIFGSQNMMRQDSIQSQSDRSVLGDRLRNNRAYSPFAGSVASGPLDDPVRKGSEELSQHRTILGLANESKRGRYSPVPQAVQGAQAQTPAPDAGIKSEHGRVFAGIGSGLGSASAGPTPTPQPLSASPFKRDEGGARLSEENLLKMSRSTSGISKRNRKAMEENNRAESDAGDAKKGPGRGKRSKYAHSYKLDLDDTAPGPRKNVAFPLSNFGRRAATPTSNPSQSVQNSHSQLPASAAARQLNKSKKTIKISTVVTQAARNRRRHLGIFKYDPVVSQPNTILPHQEKFDVSIRPNLLPSFSDPEQINCTYTVKVSRMWLRERERHLIGREQYLWGSGIYTDDSDPLAAAMHSGFIESARPSDAVLERLIEEQNPKIEGLAAPVKPAAVSEGKDLHITLVVLPQLESYTDSVRYGIKSRSWPEREKEGANPAPHDGVSFMVLKTEFLDDGIMNRRVGRTGKEKRKRLREELADRKRSFEIRDKMVEIQARNREKKGKEQRQQKSAQTTGARASLKPDEEGLKSYAGFSRLVNPSDERENHVPSNDTGDRSSATLEGVGHSPEEWFKQLNDSATPAELAATASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY89</accession>
    <name>A0A1C1CY89_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY89"/>
    <dbReference type="STRING" id="86049.A0A1C1CY89"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10200"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00431"/>
    <dbReference type="eggNOG" id="ENOG502S7RC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5402307at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="460" mass="51931" checksum="D418A2CCCC88F1AD" modified="2016-11-02" version="1">MAAITQTIAIIDRSNKVVSTSKQLKNVFKEAKMAYLERKAEIVNARRAKEEKELRKAIKAVTIAEDARSDTTRRSRRHRSHRTEREEDYEHPSTPEHPYSSESPRRYHAHVESEADGSRHLEEHYPRHVGLAAFNEELYGHHHSAPVTPYAPPPGHELVRRTTDLPLQTQPPHRPQPVRSHSVSDIDMDLAYGDFHPESLMLDPKTEQKLQKQEMSSLVLKCKMLIDEANCAQHSVRAIIAHLQGNPDAMAAVALTLAEISNLASKMAPGALAAFKAGAPSVFAMLAAPEFLIAVGVGVGITVVMFGGYKIIKKIKAHVSDKEENELVDEMLDVRELDRIEHWRRGIPDAETASVATSVEGEFITPMAARSMGHLPIPRDRSEERQKEQRKEEKRKKKHHRRIEDDPDRTVVGSENSSKSRRSKSSRSEHKEKAVVKIKKTSTLRKMFSSRDTEVVSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYA8</accession>
    <name>A0A1C1CYA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09689"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00485"/>
    <dbReference type="eggNOG" id="ENOG502SHTF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3540210at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="718" mass="79489" checksum="D325BA6F6E7A5FE6" modified="2016-11-02" version="1">MSTMSEASIYTGPWVDWSRGMIVGSTITLSARSASILTAFLALFVTIVGSCLWRILSFLSHQCSASPDAQDGIYHQHQLVFRNTGSPFEATKSFTEIAWYWRKSGRRPWTRSLPLALFALVFLLAFGAASILTSLVTRAAGAQRLIVSDNCGYWSFDPSATLEQRTLAMQYKDLNDTLVAAEYTRQCYDQNTSLNNRLRCGMYTTQSIPWSSGDTDCPFDASICAVPQAHKMGTGLIDSHYDLGINAPHSGRVGFRKVTTCSPLSVKGDFVSVITSTGDDGLGVEGDRIRKYHYGAYLGAAVDTNTTYLYNQHAFIDGFGYEVNALQVPLDDATFMAIPELNPQDADLTIIFLAANAIKYNHPTSDPFFRANFYVDLGSYNGINLSYFSADEYVSAMACADQYQYCNVEDKTLCTPLTGYQQAWAALDTTKLNLNEVQYTVASRIALSSRSLSTFHSISGRGASALRAQETIYDRVQQVPLPDHQWQIELANWFEISLAKLQHAVVEYAAPSVKTKDMPVGAYLQSPIDIVSKAMCSSQKVAFTGSTVSFSVLGVVVILAVGGAIVLLHLVLEPLVGWMQRRFRWGEFRRARWIMDDKFQVQRMAFEEAQMGGEWTNPDGGIPVTKQGDVLFGGLDGVDLTAPRLEKDWAEKKDVASEGATPPEFEDLSSDRPTVDMVHTAEACPDQSTPRSQYQYQYQAYRKPTYQALPGQESPLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYR0</accession>
    <name>A0A1C1CYR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYR0"/>
    <dbReference type="STRING" id="86049.A0A1C1CYR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10617"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00627"/>
    <dbReference type="eggNOG" id="ENOG502S6XI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18959at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161270">
        <property type="entry name" value="PspA lactotransferrin-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="3">
        <location>
            <begin position="77"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="300" mass="33499" checksum="58B934C5C0E5F678" modified="2016-11-02" version="1">MPPVDYSSTLATLRAQQAAQPLSILALAEPITTSQQRQPQPQAVSRPSDTLSASEADSSSLALTPATLAADLTHYKDLFSKLRFSYLEQVTKEKYLRSIVGDPPLLVSHGDNLALEQTLATMKHDLKAKKEEVDALVAAMEERARDVAQRYDAVQGGMELLDRVPLEIEELKREVERLGAEIAARRGDRHDGPPSDPRMRMSLAETEEALAAQRARNAEVDRMIADLQDRMPARVRDVESMDRELAELERRRNEAARLAVEGRRRREEQGGRDEMEELGRWYRASEGVMKGLMAVEGTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYU6</accession>
    <name>A0A1C1CYU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ssb1</name>
        <name evidence="15" type="ORF">CLCR_09826</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYU6"/>
    <dbReference type="STRING" id="86049.A0A1C1CYU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09826"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00595"/>
    <dbReference type="eggNOG" id="KOG0851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000117">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="12">
        <location>
            <begin position="27"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="11">
        <location>
            <begin position="183"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="14">
        <location>
            <begin position="292"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="13">
        <location>
            <begin position="451"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT53646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="608" mass="68366" checksum="7BF17997790171D4" modified="2016-11-02" version="1">MNNPADALRRIDAGCLADIFADRPGRVSNPVVQAVQIKPIAAQGGAQERHRVIFNDTKNYVQTMLAVQENNLIEEKILRKGVLVQLLGYSANKVKAKRILIVTRIKVLEEYGEHEKLGNPVPLELKEEEEDKPFNTAITSNGFYGKQESPKQSRPMPSHAKPSSSAHANIYPIEAISPYSNKWTIKARCTNKSDIKTWHNRSGEGKLFSVNLLDESGEIRATGFNEQCDQLYDVFQEGSVYYISSPCRVAFAKKQFSNLANDYELHFERETVVEKAEEQDGVPQVRYNFTPISDLQFVEKDTTIDIIGVLKEVGETAQITSKTTNRHYDKRELTLVDNTGYSVRLTIWGKTAAAFDVPPESIVAFKGVKVSDFGGRSLSLLSSGSVSANPDMPEAHKLKGWFEDQGRSGNFATHANVQGTVGAGAGSRSDPFKTISQVKDEQLGMSENADFFSVKASIQYIKQEPFFCYPACRSEGCNKKVFESDPGQWRCERCDKTHDKPEYRYIMSVNIGDHTGQLWVSCFDETGRMIIGKTADEMMEIMEVDAKKVAEIFSEAICKTWNWKCKAKLDSFQEQQRVRYQVTSAAPLNFVVESQKLIELIKQYNIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYZ9</accession>
    <name>A0A1C1CYZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ERG5</name>
        <name evidence="8" type="ORF">CLCR_09982</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYZ9"/>
    <dbReference type="STRING" id="86049.A0A1C1CYZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09982"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00645"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000249">
        <property type="term" value="F:C-22 sterol desaturase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11082">
        <property type="entry name" value="CYP61_CYP710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="529" mass="60385" checksum="D0A250478053EE3B" modified="2016-11-02" version="1">MEAMSNATSFTSPLANAELKSHQALLASGVGVLGRLWAQLNIWTVLLTLLLVLATYDQCSYQWRKHGIVGPAWKMPFIGPFLESMRPDFRKYKEKWESGELSCVSVFHKFVVIAGTPAMTRKIFNSPMFLKPTVVDVAPKLLRPDNWVFLDGKAHVEYRKGLNGLFTRQALEMYLPGQEEVYSKYFKSFLDMTRENNMTAKPWMPVFRELMCAVSCRTFVGHYMSEKVVKKIAHDYYLITAALELVNFPIIIPYTKTWYGKKAADMVLEEFAKCAAKSKVRMAAGGSITCIMDAWVKQIQDSATYRERIAKGEKVDDSEKPAQLLRDFTDVEISMTLFTFLFASQDATSSACTWLFQIMADRPEILDKVREENLRLRGGDRNKPFDMDMLESMVWTRAVVKETLRYRPPVILVPYVAKKDFPVTKTYTLKKGSMIIPSIWPATHDPEAYPNPDSFEPERWITGDADKQVKNWLVFGTGPHYCLGQTYAQLNLMAMIGKASILLDWVHEPTPISEEIEVFATIFPQVSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ07</accession>
    <name>A0A1C1CZ07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor Iwr1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ07"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10255"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00614"/>
    <dbReference type="eggNOG" id="ENOG502SE90">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040150">
        <property type="entry name" value="Iwr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063:SF1">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="3">
        <location>
            <begin position="313"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="411" mass="46280" checksum="BCBCC8C6E2B5E4ED" modified="2016-11-02" version="1">MSLPPERISVKRRRQEEPVETLCTTPSRLSNLERGDGTEKKRRVTDYYFQRVRNDTIAPISQRDTATSQAVWSKPPAPGVPPIRLTTLEGQKEDASTPKAAVKAKADSADEENHKIPGTPSAQASSKSAPTTPAGSQPARQARRFHLARHLSSVLSPHTSGGIRKSKHFIRPPLATFIERHGAVFDHEQNPLYRGQPVDKMLEAPKEENSPRTIPGEGEEPTLDTLNAFTRSPTNTFVQARPKTIRNGTSIRDHPSTWDLESDQLADELAALAMEFDPELKDKVEVEPSKERPVSPPRAPRDVAMTTHNQEDGYIYETYIRVPYEGDAGDTTNLQSDYGILVIDEEDEDLWQKYVDSEDETDWDEEDSNAEDNPANDYPEDEVSSDDEFSYNAYKYRAYGSDQEEFDDKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ67</accession>
    <name>A0A1C1CZ67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ67"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10227"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00760"/>
    <dbReference type="eggNOG" id="ENOG502RZT9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5394254at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="422" mass="44509" checksum="1C59E778391E94EA" modified="2016-11-02" version="1">MLGDLVELATTLVHPSHEPSISNITGPTMAPRSRHNKSSSIASSTGAADAVNGILAGTPGSKPSSPAGTTTRRRRQSRSTTSPPGSPVVVVTKPVARGAQPVVIEEREFEPLKFVASVVLSAVLEAALQTAAATVGVGDLAAVSRRPGTWAEVLGLLGWKVVKLGIYWVSNFDAYDVASLSLLLHTPQAILLGLFYQISPITLASIAVSAIVANSLPYYFVRPLSLSHIPSYAPKSSLRNRPILTDPYTTLATSLLATAIFAVLLEASFATYLPTWLILHFVGLRTLEPAHLGPAGLPTLLLALLPAGYAMMEFLFAPSTAATSSTVVISPESAPVLAFDPSTATFWDHIHYNSWGWYSARQKELIRRTVVLAGLLLSETVLTTWGTVEGVEVQGALGYAGVWVIGALVTGAALDWVGGPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ75</accession>
    <name>A0A1C1CZ75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative forkhead transcription factor Fkh1/2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_09626</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ75"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ75"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09626"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00771"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22701">
        <property type="entry name" value="FHA_FKH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000030">
        <property type="entry name" value="Forkhead box protein K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="140"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="349"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="349"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="622"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="678"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT53847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="798" mass="86344" checksum="EC904976D95438E3" modified="2016-11-02" version="1">MPPSKRKARRKPADLPASSDVELPDSSPSRPSAKKRKIDAEHMQVNGTRAAPSAKKKSVVPEPELEQTPAPDSGDEETEEVSQSELIDSVVSYLQVSKDVVVARAEYSNDNVQSNSPHKVSAYAKIAGRDWTYFVREQSVNFGRPPDDKPVANGASSPVADLKEVFPVHIDLGPSKIVSRHHASVYYDADYPEGEGGWHVRVNGRNGVRVNNVLIKKGLRKQLKSGDILEIAGTQMMFVTPDDKVQIDPYFIERAKALAAGEDVAPTHSQPELARYDPGSEAGVNFPSLAPAPPNFKRETTPPAQLADGKGQRGVFDSKMAMSPMYGRGMMMESTQEIDYSRDSAKDLKPPFSYAIMIAQAIFSSEDEKMTLANIYSFIADKYAFYRHSNSGWQNSIRHNLSLNKAFQKVPRRTDEPGKGMKWQIAPEYRQEYWKKQARRGGSAPSSPASGKEVNPNFRGPNGQNLGYDTSMVGQFSARDMSERSGGPPGSKMNLQFPSFNPGPPYPPGPNLAPPGPQPHEAVTPLRRRTDTINTIPDMDLEDSPLRHGQPGPTPRVGNGLPVYTLPSSVPPAHHSPTNPTLSSSYLDTPFHPSQHSIITPAPLRQNPRLAPPSTLIAPSKFMPESSPAGPQGLFWKGIMGATPGQPLPDISPIKDDDPRTNGIERHVMSSSPPPMDPNMGSPSKPARSSQAPFSSSSAVKKESTAPLAQRENGTALEEDGRFGRSFSSNGPAINRPPSSSRFPPQPPASNSDAKPSHEDDDDDGDGGFDLAKGFAPIAGGSFHSQRSSSLGVARAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ92</accession>
    <name>A0A1C1CZ92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein YAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein yae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_10592</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">May form a complex with LTO1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the YAE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ92"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10592"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00767"/>
    <dbReference type="eggNOG" id="KOG4774">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20086at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038881">
        <property type="entry name" value="Yae1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="11">
        <location>
            <begin position="106"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT53842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="307" mass="32079" checksum="C433632F7C275BFF" modified="2016-11-02" version="1">MENSPPLGRATTTESLRSQKSSPSPDAPSSPDTTITEPEQSPGADDDIWDTSSDHFPLTTAQPADHDLDATSAPYPHDDDESHPRFGRGAILSDLPALRRQHMTDGYREGLSVGKARVMQSGFDAGYPLGVEVGLRAGNVLGVLEGVIAALTSSKSGAGSVRTARASQASIEGERSSRATGITTVSASGKTGGIEMPAGSTREVGNRTAPNEEELKFVRALYARAQEELKISELLKGLGDDKIAAIPDAAAPTTEGNLTVGGKAKTEPSLPKEIEDALAKWERLVFGALRQRPGSAALVTPAGKQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZI5</accession>
    <name>A0A1C1CZI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ribosome biogenesis protein bms1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">bms1</name>
        <name evidence="13" type="ORF">CLCR_09484</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZI5"/>
    <dbReference type="STRING" id="86049.A0A1C1CZI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09484"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00867"/>
    <dbReference type="eggNOG" id="KOG1951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000232">
        <property type="term" value="P:regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="12">
        <location>
            <begin position="63"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="397"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="632"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1002"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1114"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="428"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="641"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1115"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT53959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1177" mass="133123" checksum="524667F81266ADA6" modified="2016-11-02" version="1">METQVHRPHRPSKEKKKPKKGEKNVKAFAVANPGRLAKQAVRSSDIREKRLHVPQVDRLPEEAPPIVVAVVGPPGVGKTTLIKSLIKRYAKQTLSHPSGPLTVVTSKRRRLTFLECPADSLAAMIDVAKIADIVLLMIDGNYGFEMETMEFLNALSVSGMPGNVFGILTHLDLFKKQSTLRATKKRLKHRFWSELYHGAKLFYLSGVINGRYPDREIHNLSRFLSVMKNPRPLIWRNSHPYCLADRFLDVTPPTEIEENEKCDRQVALYGYLRGTNFPAEGARVHVPGVGDLTVKEIEALPDPCPTPFLDQAMAKATGKAHRRKLGEKQKVLFAPMSDVGGVLVDKDAVYIDVKTNTFDRAADDTEDRGLGEQLMMSLQAERRLLGEADGGVRLFQGSHQLTANSEAENDTGRKSKRGVRSFAQASDTTEDTNDNEDEGSVSGDDDEDDLEDGEQSDEFPEHSGRPGFAAKQDLDDEGSEGHVAFAESDSDMGSVSEGDEMGADLSAEELEDEDYEDGGDDGGLRWKEHLAEDARKMHSSKVAFRAADLSRLMYDLTISPAEVISRWAGEKNGDIKLLGGDDDDNFFNKVKSDQDTNLEDRQTPKFDYDQLAEKWEDEEKIQTLMPRFTRGSIATGANAESDTDVEEVEEDGDDEFDEGDGDFEDLETTTEDNPVPEAELTLDEERARNARRKEELKLRFEEEDREGFANANKNEVRAAEQEFGEDEWYEAQKAMLQKQLDINKAEFESLDPVGRARAEGFRAGTYARIVLEKVPYEFVRSFNPKLPIIIGGLAPTEDRFGFVQVRIKRHRWHKKILKTNDPLIFSLGWRRFQTVPLYSISDSRTRNRMLKYTPEHMHCFGTFWGPLVAPNTGFCCVQSFSNENPGFRIAATGVVLNVDETTEIVKKLKLTGHPYKIFRNTAFIRDMFNSSIEIAKFEGASIRTVSGIRGQIKRALSKPEGHFRATFEDKILMSDIVFLRTWYPVKPHRFYNPVTNLLDAPPTSDAAAGDSDDRQRVDDGSSGWQAMRLTGAVRAAMGIPTPLVKDSAYRKIERPTRHFNPLRVPRTLAADLPFKSQIVQQKARKAPTYLQKRAVVLGGEEKRARDLMQKLQTLRNEKAEKRAKKQEERRSVYRKKVAENLEKKEEREKRERDEFWRKEGRKRQTNDEGGGGKRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZS2</accession>
    <name>A0A1C1CZS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arylsulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_09784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZS2"/>
    <dbReference type="STRING" id="86049.A0A1C1CZS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09784"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00860"/>
    <dbReference type="eggNOG" id="ENOG502QPU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651168" evidence="3">
        <location>
            <begin position="26"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="629" mass="70506" checksum="A6358ACC235C7116" modified="2016-11-02" version="1">MKSLSSALLVAALAIPGSWLGGGNGVTGFEFNAYDLGLQGIYPRHRFHSVDFEAPKPKITRWDSRCNDGNLLLTPRGPSVQGKARGPTMLDARGNLIWAGNDEFEQVINLNVQKYKGEDYLTFWTKVKKNKHRHKNKDKGKGKKKDKDHNKEDHGGDEINAYAKHPRISYVMLNSSYEVAHRIYPHGKGYKGDSHEFQITPQGTALITIYHKHKVDCTQLGLGKSCWIQDGLFQEIDIETGDLVFEWRATDHVSMLDVFSSPNRKDGYGTSKKDAFDFFHLNSVDKLESGDYIISARYMHAVVCISGKTGEILWQLGGKHNDFRDLNGATDFAWQHHVRWQGNNTISLFDNHANNVFHKPSSQSKGMIIKLDLENMTASVVQTFVHPDEILNVSQGSVQVIAESGNVLVGFGNSPTYIEYAPDGQVLCSAHFAPHIAFEILDFGLVKSYRVFKRPWVGRPNTVPDVKVKSGRMYVSWNGATEVSSWRLERAGARDAHDDEFVTIQELERDGFETSFGLDKVGGFVRIAALDSARTAMAYSAVVKAPPSSLGFLWSTLIFLFGVAVFASGFAGFILCYRRIPWLPRLPRLARVPKLLNLSGLKSRLSQGKIPRWEHEPETEPLLLDERVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZT2</accession>
    <name>A0A1C1CZT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MDH1</name>
        <name evidence="15" type="ORF">CLCR_10278</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZT2"/>
    <dbReference type="STRING" id="86049.A0A1C1CZT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10278"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00869"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="25"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="170"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="30"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT53961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="335" mass="35471" checksum="6B226BE9DCC9D43C" modified="2016-11-02" version="1">MSFTRQIFGQVQRRAFSASARQSSKVTVLGAAGGIGQPLSLLMKLNPRVSQLALYDIRMGPGVAADISHINTRSTVKGYDPTPSGLREALEGAEVVLIPAGVPRKPGMTRDDLFNTNASIVRDLAKAAADAAPNANLLVISNPVNSTVPICAEVYKSKGVYNPKRLFGVTTLDVVRASRFVSEVKGTDPANENITVVGGHSGVTIVPLISQSGHTDITGEKLDALVNRIQFGGDEVVKAKDGAGSATLSMAMAGARFAESLLKAAQGEKGVVECTFVDSPLYKDQGVDFFASRVELGPDGVQKIHEVGKVTKYEESLLEACLGDRRPEEEHPEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D078</accession>
    <name>A0A1C1D078_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Selenoprotein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D078"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00204"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02559"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="183" mass="19697" checksum="390A278C1A3C937B" modified="2016-11-02" version="1">MASEASSRVKVPRVAIEFCTQCKWNLRAAYVSATSSPEISAIAASLGTEGFAQELLQTFSTSIGEIALIPVTGGIFTVKMTHVISSTTQSIAETAPSSDATVRVTETVIWDRKIDGGFPETKELKNRVRNIIEPGRDLGHIDRSLKKGSTQPATPEESSKPESRPDAEVQDGQKNGDACEDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0F5</accession>
    <name>A0A1C1D0F5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0F5"/>
    <dbReference type="STRING" id="86049.A0A1C1D0F5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00859"/>
    <dbReference type="OrthoDB" id="5068804at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT54303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="439" mass="48523" checksum="D04D112D127C3CD0" modified="2016-11-02" version="1">MAETIGIASGLLAFAVFAFESSTTLYNTIHSFQSHPKRVRDLLEELQALNGVLGHLTDTISANAGSSLSALDLPLQRCGKCCKEFEQEIIKCSTRSKGGRTSFREWAKLRYMGDDIDGFRRLLAGYKSTITIALTDATLRKSSLHADSLEQYKDLLKTTTDDLEAHLENINEKLEVIFEQTVTDSNSEAATQQLIKEEQMSTQRCLQICAQLSQHIDQLQLTPKTSDESPDSVNPKAFPETLTNIGLQECKNSLALTAAKLEKHMRDLMDRLVEKTKTNLRSPDDVADLSRLQEEWNATRQCMGIFSKADQYLEQTTSTIDNYGLGDAVQFMVSTDGKTIRGTNRGLGWRTRQVGGHMSNDTVQQLSRDMTALLVRNVRTETSPAQAEKAAALHDGAECQPNSNFERFGKGFKLASKPVSKAPTSFTELGESLGPKPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0Q5</accession>
    <name>A0A1C1D0Q5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_00283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0Q5"/>
    <dbReference type="STRING" id="86049.A0A1C1D0Q5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00283"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10185"/>
    <dbReference type="eggNOG" id="ENOG502QS4K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000005">
        <property type="entry name" value="TfdA family taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="40"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="363" mass="41036" checksum="A888562C69743F5B" modified="2016-11-02" version="1">MAPSAVDVDAPRDIGIVQKTLFGREPLKSSKSLDQFKSIDITPVIGTEFPEGDLVQWINSPNADELLRDLAIKISERGVVFFRKQNNLTNDIQKQLIQRLGELTGKPETSKLHIHPILNSERELGGSDPEISTISSVQHDKLYKKTPYDQSQRIQSSAQWHADISFEPVPADYTSLRLTELPRTGGDTLWASGYELYDRISEPYQKFLESLTATFAQPAFNHVAEKGGFELYTKERGAPENVGSELKAIHPVVRTNPVTGWKSIFPVGGHVRHINGLTEDESKKLLDWFLELVHKNHDLQVRFKWQNENDIAIWDNRSVFHTATYDYQGEGARFGNRAVGLGEKPYFDPNSKSRREALGKLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1A9</accession>
    <name>A0A1C1D1A9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfonate biosynthesis enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphosulfolactate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1A9"/>
    <dbReference type="STRING" id="86049.A0A1C1D1A9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00906"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10109"/>
    <dbReference type="eggNOG" id="ENOG502RBUH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003830">
        <property type="entry name" value="ComA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036112">
        <property type="entry name" value="ComA_synth_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413:SF1">
        <property type="entry name" value="PROTEIN HEAT-STRESS-ASSOCIATED 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02679">
        <property type="entry name" value="ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102110">
        <property type="entry name" value="(2r)-phospho-3-sulfolactate synthase ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="318" mass="35665" checksum="36740B8E63008284" modified="2016-11-02" version="1">MATKAAVSLLGKAARPRIGSQVPRLHRFLSTTPVKNQVQTLLQDKENGFGFIRHNPRTPKPRTKGVTEIRGPYYSSYGKRHLQDVLETMGYHVDGLKFAGGSFSLMPEQSVRELIDLAHEHQVYVSTGGWMEHVLTQPDSNTMVEKYLSKCKDLGFDVIEISSGFLSFPPDDWLRLVDKVHSMGMKAKPELGIQFGAGGDTSAEDLESTGTSDPAKVINLGKKFIEAGVERMMIESEGITENVKSWRTDVIQAILRDLPQEKVMFEAADPPVFNWYVREFGIDVNLFVDHSQIVQLTCLRQGIWGMADTFGRIVSYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1C0</accession>
    <name>A0A1C1D1C0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_00848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1C0"/>
    <dbReference type="STRING" id="86049.A0A1C1D1C0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00848"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01722"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF21">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="361" mass="40035" checksum="042B2E9224611405" modified="2016-11-02" version="1">MTAGLPYALVPCLVLGVFYLSTFYTRFDLAVRIGLFYGQYAVAGAFSGCIAYGVFHIQSGDLKNWQYLFIIEGGATCVIALVAWFWMPLGPGSAWFLSKKDRAYATERMRLDNAMYAQHTYGDSGLENERLNKRDVVETAKDWKLWYVLFFNILASVPGQAFSVFLPLVVAGMGYSSIEANLMSVPPYVCGAVGLYLFAVSSDRRKERGYHIFFGLLITLIGLIITVTAQTHGAKYAGLCILLFGSYVSAPLTVAWLSGNTPEPGKRALVLGVNGFGNLSGVIGSQLFRKSYAPDYLIPFYVTLAFIAIALAGYLAYRFTLAAVNKRRKAKLARMTLEEIEDEKTNPKRYADKKYTFIYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1D0</accession>
    <name>A0A1C1D1D0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_00990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1D0"/>
    <dbReference type="STRING" id="86049.A0A1C1D1D0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00990"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10091"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="49"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT54567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="131" mass="13945" checksum="61D826CD0B1E1A10" modified="2016-11-02" version="1">MAKSGIAEVAQSGFAPAAAYDAYRPTYPDEAVEQLLQVLEVTGVKGAKVADLAAGTGKFTEILARRPEGYDIVAIEPHDGMRNQLEQKSLPRVRVVKGTADNMSGVQDESLAAVIAAQVSLDKELTGWQIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1D6</accession>
    <name>A0A1C1D1D6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1D6"/>
    <dbReference type="STRING" id="86049.A0A1C1D1D6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03071"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04684"/>
    <dbReference type="eggNOG" id="ENOG502SSVD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5396104at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="293" mass="33257" checksum="A23860854FFF839C" modified="2016-11-02" version="1">MTSSTFKICASGSRLDTSYVSFESEKGLRSPRTPTYIPDAPSVQSARPFDHTRFFAEPTHETKSRSSLPPPPTTRPMEWIWICHLCHSRYALGVTRRCLVDGHYYCSGESDKPSMRKKKKQKACSSEFDYGAWKMWGEWRRKVLRTIQNDRVFKGCESCDFPSQCRYPIDTHPLGDLGTASVTPKITVTESTPVVRRKMEQDRAKIRSTANENVDFDQILKSMVDTGVHQPNSDTLKDTTKTKVGGKKKISGSKDKVPSLELELPHCDTTLHDLVAMDWANFEEIELGKTKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1L3</accession>
    <name>A0A1C1D1L3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1L3"/>
    <dbReference type="STRING" id="86049.A0A1C1D1L3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02983"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04732"/>
    <dbReference type="eggNOG" id="ENOG502S1KN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="2">
        <location>
            <begin position="118"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="407" mass="46343" checksum="64E399E2C6DB2196" modified="2016-11-02" version="1">MTAPVPPTFSLVQFAPHGLPSLSPWFIAVVLLSYLALVRVLRFRALRKVEHQYASLVHDPYAMDYKAAHKIMHLSMLYDCPFIYAFSGQFSLLKTFTIASGTGLLVKTRQLGSSANVGRRINDTGLITTEFVVGSLDSERGSRALAKMNWMHRQYGDKITQPEMLHTLAVNILEAIRWVDTYEWRGLTYLEKVALFVYWREIGNRMGIRDIPPTLEKLAEWTEEYQKTAMAYTDDNRVCADVSLEFFLKHVSSPLRGVFRKVMMALLEQRTREALGYAAPSAAVQTLVYRFFRLRAFVVRHLFLPRLRPLDPLAKEDRKSGRLHPSQQTIEPWYVKDTAWNKFLSYLTGGSQYLPGPKFKSEGYLPEELGPAKFEKIAKDAVLKEAEAQRAYAAEGGAAVLGCPFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D284</accession>
    <name>A0A1C1D284_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CLCR_02867</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D284"/>
    <dbReference type="STRING" id="86049.A0A1C1D284"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02867"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04891"/>
    <dbReference type="eggNOG" id="KOG2509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110004">
        <property type="term" value="P:positive regulation of tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="147"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="442"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="276"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="363"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT54795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="493" mass="56352" checksum="70012CD382969EDE" modified="2016-11-02" version="1">MIEVQDLIAERGGDPQKVKDSLQKRYTSTDLVDQVIALWQDAYQSLSPHARYKASQVGAKINAVQKEIGQLKKAKQDADHLLKQKVELEKEKKQTEDEATEKEKLRDRKCKLIGNYVHESVPVNDNEDFNEVVKKWAPEGFTEEKRDCLSHHEVMTRAEIYDSERGVKLVGHRGYFLKKWGVLLNQALINYGLHFLVAHGYDPLQPPYFMKAEYMAKTAQLEQFDEELYKVIEDKDAEDKFLIATSEQPISAMFAEEWLTAQDLPMKFAGYSSCFRKEAGAHGRDAWGLYRIHQFEKIEQFLFTKPEDSWQALEDMKSTAEEFYQSLKLPYRVVAIVSGALNNAAAKKYDLEAWFPYQGEYKELVSCSNCTDYQTRELEIRYGQKKGAIDSRKSYVHALNGTLCATERTLCCLLENYQKEDGFEVPEVLRRYMPPGTPDIIPYTKELPKDTVTAKAKQPAKPKPDGGAPTGGPKREMPAADNVADKMKDSLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2K4</accession>
    <name>A0A1C1D2K4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal specific transcription factor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_02748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2K4"/>
    <dbReference type="STRING" id="86049.A0A1C1D2K4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02748"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05131"/>
    <dbReference type="eggNOG" id="ENOG502QZJZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="647"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="749"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT55039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="889" mass="98938" checksum="194662ED08E6B11B" modified="2016-11-02" version="1">MDPRGSIDGLSYDMSSFVPQQPPQIFGAYNPDGTPIPPTLPPGAYFGDYDGGLDENDPKRRRIARACDMCRKKKIKCDGKMPKCGHCINYKTECVFTQVEKKRNPPKGAKYIEGLENRLGRMESLLRMSGLLSEEEAGKTDLGTLEKRLAEKASSKESATQKSDSSAPSKSSSASLAPENSPQLGSARASTETPRDTVNSPSTDGDKSSREEVENLSEAMCSLVTNNVGETRYIGSSSAFSIFSSKGIEWVNEKTGDTSFQETIQNAVNEDDTKWQYWKPEIFGDIFVRRVFKPLPPKEEALSLFKDYFENFNCMFPLFHEPTFMHLVEKQYSKDPYEGSGWWASINVALAIAYRIRVMSNVVPQEDDQKAWLYLKNAMGVITELTLRNTDLLSVQALLGMALFLQGTPNPQPSFFLIAAAIRCSHTIGLHKRGSAFNLNPIEVEQRKRVFWIAYLLDKDACLRAGRPPAQDDDDMNVELPSEDPPDNIGNVPLADGKSKLNLFRLMCEFAVISSKVYRQLYSVRASKQSDGELLNTIGELDRELEAWKDGIPLDFRPEHEIKTSHTPLILHIVVLHFSYYNCLTTIHRMSVHHGYWTSRLSEYAIQGLNARPLNPRVFSSAALCVSAARASIHLIKYIPQGDFACVWLILYFPVSALVTLFANILQNPQDTRARADIKLMDLVVNFLSNVAHDEGSGSINRMLTVCAEFARIAKVVIEKAEKEGSKRKRRLVPEEVMRVNQSAMAQVQSQLNGWRAGSRRSSGAGGSPHPGLGHLPSTAGMAATNIAAHSPSTTTPNNTNNQIFNMSAFDNDYVDMLSAPGLSPDLGSQQIPSSTVSPLNASSFQHPFVPQDLWQMPMTFEWDWAETFGQPSYNDFILSDNMNGMPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2R9</accession>
    <name>A0A1C1D2R9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2R9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03165"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05019"/>
    <dbReference type="OrthoDB" id="4160402at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651277" evidence="1">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="159" mass="17808" checksum="87E13D166EC64A82" modified="2016-11-02" version="1">MLTFLYFALTAMIAPLVVGLPAALPNNPEAVQRADVSYTCDCIDHWFKHGLFWIRASSVTGCMSLETIPQTIYALNAIPKPDYFSNDYPNLICSLGHNECQWTYSPLDFLANTTSFPESITGGIHPRERDIPMLEKVDDPPLLLPLFVPVPKNQAPQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D356</accession>
    <name>A0A1C1D356_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CMP/dCMP deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000001">
        <property type="protein sequence ID" value="OCT55120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D356"/>
    <dbReference type="STRING" id="86049.A0A1C1D356"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00024"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00005"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047974">
        <property type="term" value="F:guanosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF161">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="94"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT55120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="310" mass="33798" checksum="3C0EBF662DA0D0BB" modified="2016-11-02" version="1">MSYQSYLKSTATFTNKNPSPGSIHRKPPPSITPSGSSIRSSVTRNDTPTSTVPVPFTPASSTSSPARPAAFTPLPSMVSSAAHQDSTRTPLTKEQIDAAVRICLDLQKTATSLHDKRPFAALLLGSDNSTILLSHYSISHVQHAETELARLAAIHFSQKYLASCTLVSTWEPCAMCTGTIYWSNIGRLVYAASEEKLKDLTGGNNEENMTMSLPCREVLKHGQKDVEVIGPISGWEETVVEESGKWWKEQQARENAGRLRGGSVNGTDKPGSLSSMRHGTPTTWTGEETVLSSIDDEGEYKAELDIDWMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6I2</accession>
    <name>A0A1C1C6I2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Levodione reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lvr</name>
        <name evidence="5" type="ORF">CLCR_00693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6I2"/>
    <dbReference type="STRING" id="86049.A0A1C1C6I2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00693"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01010"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF12">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="279" mass="29614" checksum="5B852F5166B60478" modified="2016-11-02" version="1">MATKTDVPGIAIITGAASGMGRAIALAFAVAGATGFALLDLNEAGLAETKTLVSKASPSAKIETYKCDVTQESSVISAYTSAKEAFSRLDYAVHCAGIVTFQGPSADCTLESFDNQNNVNYRGLWLCAREALRNMRGQSLDNEAYPDAHIPPHRAQKGSIVNISSGLAVYSQSGIPAYCGAKAGVTAITRSDALDYATQRIRVNSVLPGVVDSPMTNPNPEIRQWMYDNPVKKATPMRRFGLPEEIADVCVFLSGNKASFVTGACWSVDGGFCAGYSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6Q1</accession>
    <name>A0A1C1C6Q1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glutathione s-transferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6Q1"/>
    <dbReference type="STRING" id="86049.A0A1C1C6Q1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00673"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01117"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="110"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="239" mass="27430" checksum="23B8A38DDAC511F3" modified="2016-11-02" version="1">MSDEIILYDLPSKQGFAWSLNPWKTRLALNIKGVPYKTVWVEYPDLKPTFQKLGIPPNDSGPYEYTSPTVRLPNGDYVMDSRKIVDRLEALYPTPSLHLDSPYQGRIEQFLPKFVGTVRPIFMPLVPVTFLNPPSKAYFEQDRERAVGMPLQEYHAKNAEQAYRDVEPLWKELAGWYAEHDGGVWLSGGEISYADVMVLGLLRMLDRLGVAERLWPLEGGDVLKKVYDAAAKWFERDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7K4</accession>
    <name>A0A1C1C7K4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7K4"/>
    <dbReference type="STRING" id="86049.A0A1C1C7K4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06381"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07128"/>
    <dbReference type="eggNOG" id="ENOG502SB51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="163" mass="18458" checksum="ADC70E391D687345" modified="2016-11-02" version="1">MSSESQPISAERFAFAIQDLPAENLYSKAQELENSIAHLEHSNKTLQEYIDSIRLDTTLPESTRQEGDKDCSDAIQENHVVIERQRERIELLKREVERRGAKWHEVNTNGKVNGSSDDSGTNGSTADTERNAGGRLTDEELRRQMMDRLGNDEDGDEEDGMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8Y6</accession>
    <name>A0A1C1C8Y6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carnitinyl-CoA dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">caiD</name>
        <name evidence="4" type="ORF">CLCR_06185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8Y6"/>
    <dbReference type="STRING" id="86049.A0A1C1C8Y6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06185"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07639"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006108">
        <property type="entry name" value="PRK08259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802:SF1">
        <property type="entry name" value="IP11341P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="282" mass="29531" checksum="D303B6986A1CE324" modified="2016-11-02" version="1">MDSQLINVTTTPRGITTITITRPHRRNAVNPATARALYAAFLAFEADSTQKVAILTGAGGTFCAGADLIDLTAAQQPRAPKDGDNDNNASHANHLEPVQGRNIGPMGPSRLRVTKPVIAAVAGHAVAGGLELSLVADMRVVEEDAVFGVYCRRWGVPLIDGGTVRLQAIVGLGRALDMILTGRGVSAAEAHAMGLANRVVARGKALEEATRIAEQLVDFPNGCMLADRASCYYAAFDASGFEDAMRREYDEGVGVVEREGMAGAARFAGGQGRGGVFGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8Z8</accession>
    <name>A0A1C1C8Z8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8Z8"/>
    <dbReference type="STRING" id="86049.A0A1C1C8Z8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06034"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07648"/>
    <dbReference type="eggNOG" id="KOG2742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="170"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35656" checksum="F1D8A1D21A114E40" modified="2016-11-02" version="1">MTIGVAILGGGIFAREEHKPAVEASKHLTLKAVYSRSLKSAKTLEVDESQVDLYSDDSGAGKSLDDLLARTDIQAVIIALPIKNQPEYIRKVLSVGKHVLSEKPVAENVKQAAELIKWYHSEIEPKGVTWGVAENFRYTNSFVHAAEAVKGKGRQLTFRLRMQTLVDGGKYFETDWRKVPTHQGGFLLDGGVHFTAGIRMMLGKDNPLVSLSAHSAQLQKHLPPVDTVEGTAKSKQGTVGTISISFGTTHKGSEWAVGCEDGFVSISGNKVTIDDKTEEIQDERSGVPPEVRAWGEALAAGKVNEQQSPEEALADLELIEAMLRSGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C915</accession>
    <name>A0A1C1C915_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative zinc-type alcohol dehydrogenase-like protein YycR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_05771</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C915"/>
    <dbReference type="STRING" id="86049.A0A1C1C915"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05771"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07620"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08282">
        <property type="entry name" value="PFDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF3">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="9">
        <location>
            <begin position="37"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="8">
        <location>
            <begin position="197"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT44949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="392" mass="41730" checksum="CB4600AC8DC486C2" modified="2016-11-02" version="1">MSTTEVRTSGATMKAVNYQGAFKVKVEDVPKPTLEHPDDVIVKVTTAAICGSDLHMYEGRTGAEAGITFGHENMGIVEELGSGVTLLKKGDRVVMPFNVADGRCRNCEEGKTAFCTGVNPGFAGGAYGYVAMGPYRGGQAQYIRIPYADFNALKLPPGTENEQDFILLADIFPTGWHGVSLSGFKPGESIGVWGAGPVGLMAAYSATLRGASRVYVVDRVPERLQAAEKIGCIPIDFSKGDAVEQIIEKNGGMLDRAVDAVGYQAVTTGGDKEQPNIVLENMIQATRPCGGLGIPGLYVPTDPGAPDEASGKGKISLSFGKLFEKGLSLATGQCNVKQYNRYLRDLIIAGKAKPSFVVSHEIGIDDAEVAYDKFDKRIDGYTKVLIHPNGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C973</accession>
    <name>A0A1C1C973_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C973"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06392"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07694"/>
    <dbReference type="OrthoDB" id="10011777at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13339" checksum="4E9B15B9CF80A09C" modified="2016-11-02" version="1">MSSSTGTGSPPGPNVMVHVFPKPGKESRVEELIVQASDQVRVHEPWISLYRYYRVKRDVSDAEYIIVFHIEDTSRLTSRAEMPHHQAIAQANREEDLLREPLKYSVLEEMGFWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA76</accession>
    <name>A0A1C1CA76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA76"/>
    <dbReference type="STRING" id="86049.A0A1C1CA76"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05653"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08052"/>
    <dbReference type="eggNOG" id="ENOG502T1XE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5311681at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="70288" checksum="3E63ECF1083E0654" modified="2016-11-02" version="1">MTFRASHLYRNGPEVEGAFGVNSVPLTVVAHIISFLDDDVASLARLCRTSRVLWYMTLPHLWKNVTLKSYSAIRYREDVPEGLGSASPFAMGLNALVTRNVSSLVRSLSLEGEFSSADVSEHARVGRVSESTMILNIAVRAVLDQCTHLENFRWDLNVRTQPNVYAGLAKLERLESLWIRFPSNRSPQPSYELPPLPKLRSLTITHYDPLCYPDDVSTLLFHGTKLENLVMHFSPRMREQGEPSVILTHFFRKNIAAKRRLRLKSMGVYNLLNSVDPTECLHAVETAGIEHVTSVNTFGPDEDAPVVDDRSGPVNATHFIDRTWHMVVKAEEHAPRPKSLRIDQLHRRHAQDLGNFGGLEKLYLINARYKHHQPNGAPVNNPDESSSNSADSSPYYKAATDDVRSSRNTPVRAISAAAAASISLRDLYLDNICNVCGPTLRHLILPARWPLPTAITARLIRTCPNLTQLAAALDCVEDSKFEALRLLTPFLRELWALRVLAPLGQEACGEEGRRTVEAYENFVSLPDDVHEEKISSSLIERGGGPSSQSTDFAKLKYVGVGWKVWEIGPVMEEHMGRTGQTDDGYIEDGTESQNKADTVYRRRLKRIEEEDVQHVEIWRMDSLDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAA2</accession>
    <name>A0A1C1CAA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06366"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="172" mass="19281" checksum="577A13F1127CC588" modified="2016-11-02" version="1">MPLLVETHDLWDPRAVMTSGPLSKSVQAPYSWVGKDRFVLHFIPWHLAIHLFNRAVHTAQFVANLDHAESYHSWIEAQEAPNVLLRLHRSVELHHEVVALAVLGLMFRRRARKIELSPVLHATDDAVGGEDLLASDTRDPAQTGLAGILGETEQRGVLFDIVEIARSDLYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB20</accession>
    <name>A0A1C1CB20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB20"/>
    <dbReference type="STRING" id="86049.A0A1C1CB20"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01763"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03558"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="91" mass="10432" checksum="327F623B5E6B14B2" modified="2016-11-02" version="1">MDGPPLASFSLTHVRYNPADPVSYASAWLALVPQGLVVVYVTLMWASREAEIILMFAGQMACEMLNFGLKRMIREERPERRRHWLDLKAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB66</accession>
    <name>A0A1C1CB66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_01382</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB66"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01382"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03605"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03606"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF265">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="69"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT45709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1087" mass="120641" checksum="DBFE581FF087A09F" modified="2016-11-02" version="1">MADSMKMEAIQAEDATKNQVEATTELQKTQTVDTIHNDEAMKVLANYTGDETWTEKEEQNVKRKIDRRLLPILCATYGLQYYDKAMLSQAALFGLRTDLDLQVGNRYSFSASIFYLGFIVGAYPAIVLAQRFPIERVASAIVCVWGICLMCTAACHNWQSLYAQRFFLGFLESGISPMFMLVVGQFYKKDEQALRMGAWYCCTGYVSIVSPLINYGLGHIHGALSPWRYMYLVAGALTILWSVVILFFMPPDPIRAKGFDERERFIAVARLRTNNAGVRNKHFKKEQLFELLLDVKFWIVFSMAFLIMIANGPVSTFTPIIIASFGFNTLNSLLLVMPAGAIIGTIEWVAPYVAYKVPHMRAYLVSICEIGTIVASLLLWLLPRDSTGGLLFGAYVLATFGGGYAVLMGMQIANTAGYTKRSLASSGIFVGYCLGNFVGPLLFKPEDAPRYAPGFLAVVITSVISALLSIVYRMICVWENKKRDKAGTLEAFEHAYEDDLTDKTNPQFRLQRAKVCVCVYGPAEPEDSLAHHGGSQLDRVQRNMPFLAGRSVPIPGKDILSWMFDEPKFDQDKAVYIDAIDPARCITANQARVLIRQLIAGFHAAGVRPGDTVCIHGFNSIYYPILFLGIIGVGAVFAGTNPAYTQFELSHHFKTSCTKFVIVEPGLLPAVLAGAKESNIQQSNIWIFDNQNEAIPKGFDSWRMLLNHGERDWIRFDDEQVSKRTTAARLFSSGTTGLPKAAALSHFNLVAQHILVNEVHPVPYETRRLLYLPLFHAAMVPAAHVAPLRSGHTSYILRRFELEPLLSSIDQYKLTEMILVPPVAVAVLKHPSLHKYSLKSIKVVLCGAGPLSKEHQGAFQTILGPDTSFTQVWGMTETSCVASKFYYPERDDTGSVGRMMPNLDVKLIDDNGRDITAFDVPGELCIRGPTIISGYFNSPHATKDAVDGEGYFKTGDVMYCDSKSKKWYIIDRKKELIKVRAFQVAPAEIEGVLLAHPQILDAAVIGIKKHDEPDVELPKAFVVRKLGASALTEEQVKAYCGERLAKYKQLTGGVAFVDAIPRNATGKPLKRILRDMEKADAAKGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC16</accession>
    <name>A0A1C1CC16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative metabolite transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_00417</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC16"/>
    <dbReference type="STRING" id="86049.A0A1C1CC16"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00417"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09991"/>
    <dbReference type="eggNOG" id="KOG0569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="107"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT46021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="567" mass="60574" checksum="137E4DC30C97F759" modified="2016-11-02" version="1">MDSFLFAHRKAPPTRASTMEIADNSSACLQADCAVTLGSTPRRALSLPLLSCLSPYYKMGRAILTRTSSGYRAIKQAALADLSPNPPQRSPMAPPQLSGLTPCLLYSIGIVTLGPLLFGYHLGELNAPQKVITCKADEIPGYVALGLPQCLPMNAFEWGMIQAMFTVGGFFGAIFSGALATSFGRLFAMKWAAFFLASGPIAEALAGKMWLLALGRALSGVGAGAATVVCPLYISEVSPQNQRGFFGAFTQVQINFGIVVAQLLGYFLSTSGKWRWILASGSYIAGLMFFGLTITPETPKWLAANNRPRMARGVLQRLRGKNADIREEMEAWDMSGEAEEESLLGPPQGPRPQKQANMSIIDVIKIPKYRRAVIAVTGTMMAQQLCGINSVVMYSVAILGKIMPKQAGLITVIVSAANVLITLLASPLPDKIGRKTCLLISISGMGSASALLFAGLGQDIPWLTVVAITLFVASFGVGLGPVPFILTSELVGAEAVGAVSSWALASNWLSTFLVSMFFPILNNMLGNKVWWIFAGVACFWAAFVGVFVPESRGKASAEEVWGRVRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCZ1</accession>
    <name>A0A1C1CCZ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF985 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01293"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09125"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387:SF3">
        <property type="entry name" value="DUF985 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="RMLC-LIKE JELLY ROLL FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF985" evidence="2">
        <location>
            <begin position="32"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="276" mass="30560" checksum="E137CC6B993F58CB" modified="2016-11-02" version="1">MRAIIPRTDTEYVSSLLSSPRRDHTPAITATMTTLNLQDHIEGGHFVETDRDPLRVPNPFKSQSQSQSHAHGPNATAQDPASEDTRNASTTIYYLVTPRSPVGYFHRNRARTVHTLHWGRGRYVVLHHVDRASDSSSSSSSSSSSSSSALSGETAVPLKVKVEVETFVVGKDLARGEKLQWIVEGDKFKASFLLPDDENENENENGDGTAGESESEKGCLISETVVPGFEYADHDFLTAEQFVKSLDADARDELKWLVRRDERERLDEVVKAMGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDC2</accession>
    <name>A0A1C1CDC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDC2"/>
    <dbReference type="STRING" id="86049.A0A1C1CDC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02080"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01253"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="262" mass="28811" checksum="D7A9389B0A09D409" modified="2016-11-02" version="1">MSLNKQHKPVIALVGAGPGIGEAVARRFVAESFYVALLARTEDKLDKMARGIEADHGAGSAKYYITDLRQESSVLSSFQQLRDDLGPVSVLVYNAGARRVNGRPLLDTSSEEFENFTKINLFGAFWATKCVLPDMLAAGKGTILFTGATGALRGNPGLSSFSPGKFGLRSLCQIITREYQAKGIHAAHIIVDSPVDGKLIGEWSRREWKRRGQEGKLDDVDAHLVAPADLAHTYWFLHTQPRSSWTHELDIRPQGESMFSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDH0</accession>
    <name>A0A1C1CDH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBX domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ubx2</name>
        <name evidence="3" type="ORF">CLCR_01919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDH0"/>
    <dbReference type="STRING" id="86049.A0A1C1CDH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01919"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01315"/>
    <dbReference type="eggNOG" id="KOG1364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270602at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="450"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="529" mass="58370" checksum="745FAE4D38FD1648" modified="2016-11-02" version="1">MDEAIATVVAVCGTTPELAAQYVQLADGDPNQAVQLFFENGGVDLAGPPSGPSSRPPPPSASHHTGEASDPIDVDAEDTISDDNDPEITGFRKTTQRSGAAYEDDEAMARRLQNEMYGAGATEEDVRAPIARQAETLVGGYGGGLAAMGGPTYSSAVEERMQAIERRRHQARTGIFNQHQPTSIWDQGAYASPDALSESTGGASEASARSTRLARLFQPPWDLMYKGEWENARAEGKEQKRWLLVDIQDPSIFDCQALNRDLWKNEGIGETVRENFLFLQYNKDDPRASQYVQYYFPNYEIAREYPHVAIVDPRTGEQIKLWARKVPAAPEFLMQLHEFLDRYSLDTHARNPVAKRRSEAKKEKPVDQLTEEEMLERALQASLAAQNEEQKAAPAEDPDDLTRSVGDLRGAQTAANNDSMDVDKNGTEETAEAADFAQIPSDRPHTEPAAGPGVTRVQIRHPGGRIVRRFAEHDPVQRIYEYLKADPLEGKAGSVFELVSMGKNLMDARHETIESAGLKNGTVMVEFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDM0</accession>
    <name>A0A1C1CDM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Organic hydroperoxide resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ohr</name>
        <name evidence="2" type="ORF">CLCR_02121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02121"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01274"/>
    <dbReference type="eggNOG" id="ENOG502S77G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60422at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797:SF2">
        <property type="entry name" value="ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="183" mass="19698" checksum="9EA9275EA9CA3560" modified="2016-11-02" version="1">MAAIRALYASASRAPLRATPRTVQIHPIRTSLRHLNTDTAPVLYSAHAKVVGARTGHVEGDDLNVDLTMAKALGGPGDKGKTNPEELFAAGYGACFQSAMNASAISLKVQMPEKKEDSIVETTVHLVGDMKKLDMGIRVDMKVSVKGLNKTDLEKVIEKAKEVCPYSRATRGNVTTNIEVVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDW7</accession>
    <name>A0A1C1CDW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02171"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="109" mass="11417" checksum="B81463E9AF6B8CBD" modified="2016-11-02" version="1">MASDSNQGAGDDSSHHNSMVVSSTGIDDRNPAVAGVAGKLDPASKPLTLREADLSPEAVAPSRALQRYASSAARSEAWHPHRAARQHFTHLIAEVDTILSAIEGAQVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDX0</accession>
    <name>A0A1C1CDX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDX0"/>
    <dbReference type="STRING" id="86049.A0A1C1CDX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01865"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01371"/>
    <dbReference type="eggNOG" id="ENOG502SDCC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2555519at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701:SF1">
        <property type="entry name" value="UP-REGULATED DURING SEPTATION PROTEIN 1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="670" mass="71480" checksum="093E39276732E608" modified="2016-11-02" version="1">MPADKPTKSNTSKPLTPALSSNFRNVKSPLTPRVAGSPTPSPSQPFVRAKSPAKPDQTTTPLGGNITPRSAARKSRADTESPLAPAQPRVPPNGRRSRASSGNEAQKSPAQGLGITSPRLVASTPTLAKVGPPSSTPVVTVHRRVSAAKSAVEGTKDVSSKFFHASDVKSTIGSPGLEESHRFTPKPGHFFVGSPPLPATSDNVKGRSEPDENFFRANDIPQNTRSKRTVLPHIATDRLNSPAGRGTPPQSPKKSHGMIPAEPSSPRKFHPGPTPSPAAPRTTADRPKSTSSSGSPFEAGTQGHRKSLSADSKTSQPTRKLSGPRAQVPQPLDLRLTPTLSPRTAASHLSPTTLSPRSISLASTNTIPTSVTSDTDVSEIAIPATLALATPSEQKTEPPATPVQPNVDLASNARRERKVLDLEISNSSLLAINKTLERELRKQSTELRRYRRLSRSGRLSIAPSARTVSGQTNLSLDTVTEIDGEGQHLSDFEDESDLSDHDDEDSSLLSNDSGSVTSPSARSRQRARDEKRLMQDLSRHQQLLIDSQKLSQSIKRCLTCTDDLIREGNKALEYRVGIGDIKLGGRVLNDDELDERGLASGVEEVEARQGLLSPSVAKANLDHAQLWAVEQLPPPPSPGAPEPAKDAMALASLDELTDLLESVNAELQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDX1</accession>
    <name>A0A1C1CDX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mug40</name>
        <name evidence="6" type="ORF">CLCR_01859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDX1"/>
    <dbReference type="STRING" id="86049.A0A1C1CDX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01859"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01372"/>
    <dbReference type="eggNOG" id="KOG2094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000001">
        <property type="entry name" value="DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000003">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000014">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000010">
        <property type="entry name" value="DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000039">
        <property type="entry name" value="Polymerase (DNA directed) kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000012">
        <property type="entry name" value="Putative DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002677">
        <property type="entry name" value="PRK02406.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="5">
        <location>
            <begin position="133"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="633"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="635"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="692" mass="77798" checksum="4E481CE940AF74A0" modified="2016-11-02" version="1">MTSTDTQNASSPDVNRAGDNGHDNTNQTEPAQAAVPEASQHHSLRHHLLGPSLTKAGQDGVDQKKVSEIIYEASKGSKYFNNEEVKDKTLTLKIDRILKQKAQLEKLDLRSDQRRADDYIASLELSRDLSQYVVHIDCDAFYAAVEEIDRPELKTVPMAVGQGVLTTCNYEARKYGCRSAMAGFVAKKLCPQLICLPLNFDKYTAKAKEVRAILGEYDPRFESASIDEAYLNITDYCDAHHIDPEAAIEQLRNEVHEKCKITISAGIAPNAKLAKICSNKNKPNGQFRIPNDRAAVMSFMSTLPVRKVNGVGRVFERELEAIGIKTCGEIYAQRSYLARLFGEKAFQFLIQTYLGLGRTVVQPADEYERKSVGTESTFRDISSKEELREKLRHTAEELEKDMARVEVKGRTLVLKVKLHTYEVFTRQFAPPKAVHLAEDLYNYSVPMLAKLEREIPDFRLRLMGLRCTHLVSTKKNTGDFFRRKVNTTQANEKPNDGGEWEVWPDAEFEDAARQERQEEMDELERLSQEQERRQQHADEAGFDADLGEEHTSTADWHEPFGRYKYGSEPNSPASVAKAGHLRNQGAAPSARKQNATQLWECPICQLPQPANDRDFNHHIDLCLSRQTIKEAVAETDGPSRGTSSRSSPEVVVPGRSRLTNTTNGKAKRKAAGSRSVPGEVAPGRKQKKLFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDZ4</accession>
    <name>A0A1C1CDZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PRE10</name>
        <name evidence="6" type="ORF">CLCR_02038</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDZ4"/>
    <dbReference type="STRING" id="86049.A0A1C1CDZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02038"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01423"/>
    <dbReference type="eggNOG" id="KOG0184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000044">
        <property type="entry name" value="Probable proteasome subunit alpha type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="300" mass="32529" checksum="CFCD63927194BC74" modified="2016-11-02" version="1">MVCIAMLFWPRTGYDLSNSVFSPDGRNFQVEYAVKAVENGGTCIGIRTKHGVVLACEKIITSKLLKPGANRRISTVDRNAGIVTSGLLPDGRHLINRARDEASSWRQTYKAPIPTSALASRIGSYVQAYTLYSSVRPFGVTAILGGWDSEAELGVDGQVGEGPKSGSGGKSDDETTKRGGPGLYMVEPSGLYWGYYGAATGKGRQAAKAELEKLDLGSPTCALTLKDAVMEAARIIYVAHEDSKDKEFELEMTWISSLDGPTKGRHEQVPQELLEEAEKTAKKNLEGDDDDDEEEDAMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE47</accession>
    <name>A0A1C1CE47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-binding alcohol dehydrogenase domain-containing protein cipB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cipB</name>
        <name evidence="4" type="ORF">CLCR_01984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE47"/>
    <dbReference type="STRING" id="86049.A0A1C1CE47"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01984"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01444"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="14"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="344" mass="36185" checksum="8B1F86C686C846E0" modified="2016-11-02" version="1">MAQTNQAAWLNEVKQNFVIGSADIGKPAKDEVLVRNHAIAINPVDHAQQSGSYPPGRLPRILGNDVAGEIIDVGEGVGQFRKGDRVLGHCTALNTDEAKHGGFQEYTVVPTVGCAAIPKDMKYEDACVLPLAISTAALGLFHREHLGLRLPRAEQRESPQGDAEAVLIWGGSSSVGSAAIQLAVAAGYTVITTSSPRNYLLCKSLGASEVFDRASLSIVGDLTSAMQRYKFAGAFDAISTRDTQLNVAQVLAQLGGGRIALTLPATPDMPATVNARMIFAAFILSQDKALGREIYGDFLPAALNDGRIKPAPSADVVGHGVEHIQAAVDKLRAGVSGSKVVVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEG0</accession>
    <name>A0A1C1CEG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphoglucomutase</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Glucose phosphomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">pgmA</name>
        <name evidence="20" type="ORF">CLCR_02354</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate. The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate. Key enzyme in hexose metabolism. The reverse reaction is an essential step for biosynthesis because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEG0"/>
    <dbReference type="STRING" id="86049.A0A1C1CEG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02354"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02505"/>
    <dbReference type="eggNOG" id="KOG0625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000006">
        <property type="entry name" value="Phosphoglucomutase PgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="15"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="18">
        <location>
            <begin position="186"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="301"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCT46914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="555" mass="60704" checksum="934F938D859A90FB" modified="2016-11-02" version="1">MVNVKEVEFKSFADQKPGTSGLRKKVTVFKQPHYSESFITSILLSIPEGAEGAFLVIGGDGRYWNPEVVQLIAKIGAAYGVKKLLIGQNGILSTPAASHVIRIRKATGGILLTASHNPGGPNADFGMKYNLSNGAPAPESVTNKIFEKSKTLTSYKIADIPDVNINEIGTQKYGDLEVEVVDSVADYLNMLKDIFDFDLIRSFFKSQPDFKVLFDGLSGVTGPYGVAIFQGELGLGPESTQNCQPSPDFNGGHPDPNLTYAHSLVERVDKEGIHFGAASDGDGDRNMIYGKNAFVSPGDSLAIIAHYAKKYIPYFQKQGVYGLARSFPTSAALDLVAKKQNLSLYVVPTGWKFFCSLFDTNKMSICGEESFGTGSNHIREKDGLWAITAWLNIIAGVGKETGKFPSIAEIQKQFWDEYGRVYFTRYDYENVSGDGANDMVKYLKEKISKSDTVGSAIQGHKIVEADDFSYTDLDGSVSKNQGIYFIFDDGTRIVVRLSGTGSSGATIRLYVEKLEEDKSKLGEDTQAYLKEPVGLAIELLQLQKFIGRTDPDVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF87</accession>
    <name>A0A1C1CF87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LEUA</name>
        <name evidence="21" type="ORF">CLCR_02294</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF87"/>
    <dbReference type="STRING" id="86049.A0A1C1CF87"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02294"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02299"/>
    <dbReference type="eggNOG" id="KOG0454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="7"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="537"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="499"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OCT47131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="758" mass="83340" checksum="E6108F13670D244F" modified="2016-11-02" version="1">MPLTLYDKIYQEHLVNPDDKEAPLLYIDSHLIFEVPTAQAFDGLRKNNRPVRRTDLTLATVDHNVPTDDRSKYQDAVSFVKEPQARTQITLLEKNIKEHDIRYFGMSDRRQGIVHVVGPEQGLTLPGSTLFCGDSHTPTHGAVGALAVSGGTSDIEHVLATQTVLQKKYKNFRVRVEGELRLGVYSKDIILHLLGKIGTAGATGCVIEFCGSTIRNLSMEARMVLCNMSIEGGARTGLVAPDEVTFEYLKGRPLVPSGAEWDKAMAYWKTLYSDEYARWDFSVDIDAADIAPSITWGTSPDDVIPITGHLPDPTDFDKEEPLKAAAIRRALKYMDLKPKMPATDIKIDRVFIGSCTNSRIEDLRAAARVARGRKVADSVYAMVVPGSGLVKQQAESEGLDVILKAAGFDWREAGCSMCLAMNPDVLTPGERCASTTNRNFEGRQGPGGRTHLVSPAMAAAAAIKGHLTDVREFLTTGNGSIAVTQLTLEGDRVSSYGKVASSASAPDSESPNGTVAKRPAEQAKRSVEGIPKFDILHSVPAPFNMRNINTDLVIPGDFLKTTKRTGLGPHLFQELRYDSTTHEEIPDFVLNQEPYRQSKILVCTGENFGCGSSREHAVWALVDFGIRCVIAPSFASIFFNNSGKNGLLAIPLDDTAAVQKIHAEGLAKREVKVDLPNQEIRDADGNLIASFKVDAYTKHCLLNGLDDISNTLMSEEKIYEFETKQQTKFPWLFGRIRKLQSPRRLGLHLPGAQDVFDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFM4</accession>
    <name>A0A1C1CFM4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02627"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02116"/>
    <dbReference type="eggNOG" id="ENOG502QTS6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="192" mass="20618" checksum="C24788724D0044FE" modified="2016-11-02" version="1">MAQWVSFEDMFNANKGVMRVSCVNLGSDNGPDDSEEEIDLVLNAVQYVSYLTNVDHRFILAILLQESKGCVRVRTTNNGVPNPGLMQAHDGAFSCNMRGNLQTPCPASQIFGMIFDGVGGTSTGDGLAKILNQLASSSNDAQAYYRAARQYNTGSIAQDGDLDVGGRSTNCYASDVANRLTGWVWAESACSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFQ0</accession>
    <name>A0A1C1CFQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_02493</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFQ0"/>
    <dbReference type="STRING" id="86049.A0A1C1CFQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02493"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02132"/>
    <dbReference type="eggNOG" id="KOG2629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="255"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="347"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="188"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT47302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="387" mass="40878" checksum="7BECC7FD7D3185C9" modified="2016-11-02" version="1">MAPREDLVASAVVFLQDPSVASAPVEKRIEFLKSKNLTQEEIDLSLARVAGDAGQQLPPPQNAPYYPAPARGPPGPRYPYPYNPYGEWQQPPPPEPPRRDWRDWFIMATVVGGASYGLYTLAQRYIKPLIAPPTPPQLEQDKAAIDEQFNKAFALLDTLSSDTAALKDAEEARTQRLDTAITDIETIVAELKAANMRREDDARRMETEIRTMKDSLPRSIDSVRDASERQLKELSTELASLKALMGNRLGSASFSPAGQGIARTQPGTFPGPGASASTGAAATSTTETAAGNNAVNPPRPTPSYTASASAVPTSSSVSTARPASTTSFGSSGNKAAIPAWQMAAANKAKDINGPSPAAASHNSNVPVTNVPSQQADGAEAVAALNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFR4</accession>
    <name>A0A1C1CFR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ndc80</name>
        <name evidence="16" type="ORF">CLCR_02297</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFR4"/>
    <dbReference type="STRING" id="86049.A0A1C1CFR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02297"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02133"/>
    <dbReference type="eggNOG" id="KOG0995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.30:FF:000001">
        <property type="entry name" value="Probable kinetochore protein ndc80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057091">
        <property type="entry name" value="NDC80_loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24487">
        <property type="entry name" value="NDC80_loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="14">
        <location>
            <begin position="118"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Kinetochore protein NDC80 loop region" evidence="15">
        <location>
            <begin position="460"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="99"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="519"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="324"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT47301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="744" mass="84749" checksum="187201263D1EEE63" modified="2016-11-02" version="1">MSQPPGLFSVRRPRETLGNITNLSAIPQPASTVKRASSSAEFHTAQHVRSTSINHSIQRPAQPVFHRSSSGGNLADMGMSTARRSTSVNIFANQHTGRQSLAPNQLFGSQTPASQSLQRRSSIFSRPAGHAPAVHQSFFSQPPPAAGAPKDPRPLRDGSYRARLSQELLEYLTQNNFELEMKHSLTQNSVKSPTQKDFTFMFQWLYRRIDPGYKFQKSIDVEVPPIMKQLRYPYERDITKSHLVAVGGQNWPRFLGLLHWMMQLAQMLDNFTRGAYDDACAEAGVDVASDRIVFRFLFGAYQDWLQMGPEDDEESEDAALQPHIQALNEEFERANAKHAEELKLFEAEHEALKAQVDEFERNAPDIAKLDKHFKILEDDKKKFEEYNANVQAKIEKYDSRIKILDAEIQKVEADLAVVEQERQALQHSVDRQGLNIQDIDRMNTERERLAKSHEDALVTLDEVNKRVLEKEAETARKLEELEATIKRYNSLGYQMSVIPSTAVNAKGQDYELSLNLSSDNFSSSTSQPRRSRASPVESDRLLADTNTGYSPSHLLNLDLRGTVRNAFISLRKEINERRKALSESDLNARDFLDNISEALHEKNTEIDNLNYRVNEAGRLYSVLKENGTTQHTQQTSAIEKLEKELSRMREGLARGVVELEQREMEVHIAYEYMREESARVREELHGGIERLLEDVIRFKVHVQKGLEEFEGWVGEEVEVELLGDELDNMTLEAQEGPAKKEDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFR6</accession>
    <name>A0A1C1CFR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lactose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LAC12</name>
        <name evidence="10" type="ORF">CLCR_02375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02375"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02076"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="30"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT47360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="532" mass="59858" checksum="071711CA6DFAED28" modified="2016-11-02" version="1">MSKGYFELAGRQFPRKTWYRDPALRRTYICLMFVVLTSATNGYDGSMMNGLQSLQPWQEHFGHPKGGKIGILNAIMSIGSLSAIPFVPYAADYLGRRMAILTGCIIMMVGVVLQSISAGFGMFLGARFLLGFGIAIAHGASPLLITELVHPQHRAIFTTIYNTTWYAGSIVAAWLTYGTDHINNNWSWRIPTIVQAAPSIIQVFFIWFVPESPRWFIAHGKEEKGLNVLYNVHANGDRNDEMVQLEFVEIRDTLKLEKEIEGNQWLELIKTKGNRRRLIILLSAGLFSQWSGNGLVSYYITKILTNIGYTDTLTQNLINGVLQIFNLFIAVGACFFVDKVGRRKLFLISTTGMLVTFIVWTICSARYAISGSRGAANAVVGMIYIYYFWYNIAWSGMLVGYCAEILPYNIRAKGLTVMFLMVDVALFFNQYINPIALDHIGWKYYIFYCVWLAVELAVVYFFYVETRNTPLEEIAKHFDGDQALVAGANASHKGLTLAAEMGLDGTITQRHELDEKRNSVQVENAAPTKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG82</accession>
    <name>A0A1C1CG82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oxysterol binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_03287</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG82"/>
    <dbReference type="STRING" id="86049.A0A1C1CG82"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03287"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01917"/>
    <dbReference type="eggNOG" id="KOG1737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13289">
        <property type="entry name" value="PH_Osh3p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000369">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000013">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="222"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT47466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="977" mass="107776" checksum="E95B379D8A32BD6C" modified="2016-11-02" version="1">MAGLEQIEVHSRNYLVRWVNVKHEHTISWTVQPHKKSLNLGLFKHPGPLSTLHGSSTSLNPPSPTHPPDDDEKEKAEAQSTAVEKLTGIGLKQVKWIGKCEADKVTQGKHDVRLGEAGNYALVFDNTFSKSISKTATIFLLTYPTACQAQIQFGAQLQHPQSMASAMAIANNASTLFKRSPKLKAKDKESVDSLRQASISQQSAGGSIVPVPEGPSLAGDPSSIHTGVLHKLRRKKHQGYARRFFCLDFTSSTLSYYRDRNSSALRGAIPLSLAAISANSKTREISIDSGVELWHLKANNDADFAAWKEALETATKLMLETKIPTDNLHLGPGGNLEGAASSSFDEQEWARLETLLSRISGTRDAVRRLCLDTLAQPGAMPSPRLGSASPSTTPTEGPSGEDYFRQDDKRPFWKRKASTTATQSNIFKRSVSAQLAVPFPSVEPSLRNGTPPPTAGSIAARPRSHHEESMYDHCRALLHDLDSVVGEFSSVMAEGKIRRTTPPKSAVSRLSIQSVDSQEYFDAEDKMHVLDIHGDTDHEGFEDIPEGDEDSATSSDIGEDSIDVFKRRSGSVSSYLPPRAKSLAPLPLQPITRRQNVAAPTVMPPSLIGFLRKNVGKDLSTISMPVSANEPLSLLQRAAEQLEYSQLLDSAGKCHDTFERLMYVAAFAVSSLSNNRVKERSIRKPFNPMLGETFELVREDRGFRLISEKVSHRPVQLALHAESENWTFTQSPLPSQKFWGKSSEIINEGKARLVLHSTGETYSWAAATCFLRNIIAGEKYVEPTGTMTIYNDSAGHKAVVSFKAKGMFSGRSEEVEVQTIDSQGQELSIGLHGTWTDSLQLKEPGKLGQRNTIWSAGALVPNAPKHYGMTLFAAQLNEITEVEEGKIAPTDSRLRPDQIALEKGDHEAAEHLKNQLEEAQRARRREMEASDKAWQPRWFTKVELGDEVVWKLRTGKEGYWEERARGEWTGVVPVLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGE6</accession>
    <name>A0A1C1CGE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03589"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01807"/>
    <dbReference type="OrthoDB" id="4118218at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40724" checksum="05DD38808FF557F2" modified="2016-11-02" version="1">MSRHQTGSAAPLPTTSTGSASPRATLLTDLPPEILLRVCEYLVPEQREPMPLTDDEFHRHRVERRVAGVSGRDTVEPFHLRGFRADVAKADRPNHLANFAATCQSFRDQARWITGERSFALTIGYAGITFEGVRDVRPLQGCKSSESNAEPEHSVPGNIAFNVLIHTLSNIKKLELHITIKMSRLGLGRTELFVKQLAGQLSALRDRGSRISHVDLKVVVGFTRDQEPRGENREIRLVNAVVDLKRFMKEKGNETFADVAARAVPEVLHPLALSLRGHPAIDLQPQGHDPPPDSESREHQPAAGFKVTVKWGDHMIRWGWQFDPTNLGPTQVFRSSDPIRRGSFQLLCDEVQERFCRTAGMPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGG8</accession>
    <name>A0A1C1CGG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_03404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGG8"/>
    <dbReference type="STRING" id="86049.A0A1C1CGG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03404"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01787"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF150">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="88"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="582" mass="63984" checksum="045D0FD7B950327F" modified="2016-11-02" version="1">MASTMDFKQSSGTNSEHDTARSADHKNARDTITISTQEAPGSQDKGSALNDIEAQNSDALEESSDHGQSQSQSQKAYTAFSPRAKWFIVVMTAMASFFSPLSGQIYFPVLPILTDAYHLSPSLINVSITTYMIFQGLAPSFMGTFSDASGRRLGYILTFTIYTAANIGLALQDSYAALLVLRCLQSAGSSGTISFGYAVIADIATTGERGKYLGPMAAGVLTAPAVGPAIGGLLTQFLGWRSVFWFLTIISGSYLVVYIIFMPETHRKIVDDGSIVPQQWWRQSVVQYLDSRRRLKKMSPQQRNEYERTRQDLLAKERGTKLRFPNPLESFFILMNPDALCLISYAGLMMFSNLVLMTSTPTVFPRLYGLNVLQVGLCFLLRRPLGVAAAVGAFCNGYLLDRNYSRIARKLGRTVDRKRGDDLRDFPIERARLQAVFFAQALQVAALLPYGWALEREAPIAVPLVLQYVLGFSVVVASNSISTLLSDIYPGSVATASAASNLLRCLLGAVGAATVDSMLSSMGLGWSFFFVGLLMASATGLLWAEMTWGMGWRQKRWQKVEMKRQAEEEKKVQAEQIKDSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGV3</accession>
    <name>A0A1C1CGV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="14">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">mcr1</name>
        <name evidence="17" type="ORF">CLCR_03555</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May mediate the reduction of outer membrane cytochrome b5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="14"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGV3"/>
    <dbReference type="STRING" id="86049.A0A1C1CGV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03555"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04601"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8 14" id="KW-0520">NAD</keyword>
    <keyword evidence="7 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="91"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT47740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="376" mass="41514" checksum="157E47AABDD6C080" modified="2016-11-02" version="1">MLARSVLRACGPVRQSIRGYASEAQAPKSSSTPYIVGAAAIGTGILGYSFLGSSSKTSKTDGAPSQSTEDQKNINQQKEEAPGKTFTGGEQGFVDLKLKEIIPYNHNTKRFKFALPDEEHVSGLNVACGRVIDRGRLKAAIITKFKPEDAEKPVIRPYTPINDEGKVPSHPLDFVPLQSLQPTYTLADARGYLELLVKVYPKGPMSEHIHGLKEGDTLSFKGPIPKYPWSPNKHSHITLISGGTGITPMYQLIRAIAKNPEDKTKVSLIFGNIKEEDILLKKELSDLEKEFPQRFRVFYTLDNPPESWPYGKGFITKELLKEVIPDPKTENIKIFVCGPPGLYKAVSGPKVSPQDQGELSGILKELGYTKEQVFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHE7</accession>
    <name>A0A1C1CHE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_03315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHE7"/>
    <dbReference type="STRING" id="86049.A0A1C1CHE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03315"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04465"/>
    <dbReference type="eggNOG" id="ENOG502QPU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000131">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000174">
        <property type="entry name" value="YIR007W-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="69"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="662"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="573"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="579"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT47887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="783" mass="87903" checksum="807D1842F858D073" modified="2016-11-02" version="1">MATAGLTIDGVRFRDSDGREVTFRGINVAGDCKLPRHPPQPSHETQGFYDAENVSFVGRPFTEEEAHVHFGRIKRWGYNVIRYIFTWEALEHAGPGKYDEDFIDHTIKILRIAKSYGLYIFMDPHQDVWSRFTGGSGAPLWTLYACGLNPEAFNATQAAVVHNTWPDPAQFPKMLWPTNYTRLAAETTFTLFYAGRDFAPNAIIDGKNIQDYLTDHFIAACARLAQRIHDAGGLEDECVIGWETMNEPHRGLIGWEDLNALPDELRMRKGTMPSPWQSILTGSGRAAEVDVYDFNTFGPYKSGTELVDPKGVSAWLSPSFDDTRYGWNRDPGWKLGECLWAQNGVWDPSQDQLLKPNYFASIPKSREKLDYIKYTNLYYMQHYRKYRDAIRSIHKNCMILVQSAVLEIPPSIKGTPDDDDRLIFASHYYDGITLLQKHWNKYYNVDVFGILRHKYSSPVFAVRLGEAAIRRCLRDQLSAIREEGMEYLGDHPTLFTEIGIPFDMDDKYAYKTGDYSSQISALDANHFALEGSGAQGYTLWTYVVQNDHEWGDQWNGEDLSIVSVDDPLLPSASDLSGLPSANPSTTSLGQRSAGTGTTLSDSTTIDPSNLKDALKTPTIQQRPARPIPTSQLPPSEPNTNTNTNTNTNTNATGYRAAEAWVRPSPIATVGSVQSYGFDLKSVTFTFSLTSDAPTKETVPTEIFLPDFHFPPGKTTVEVTGGRWRIDSVDVDGEGMQVMKWWHGAGDQSMTVKGMKRKAGALMEEDEEADSGYLETMRENCRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHP0</accession>
    <name>A0A1C1CHP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pkp1</name>
        <name evidence="12" type="ORF">CLCR_04134</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHP0"/>
    <dbReference type="STRING" id="86049.A0A1C1CHP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04134"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08153"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="11">
        <location>
            <begin position="24"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="10">
        <location>
            <begin position="287"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT47986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="415" mass="46991" checksum="63D6C92849C46C3D" modified="2016-11-02" version="1">MAWKPSEKLVQTIAHYASFPPTGVSLRQMVQFGDKPSAGTLFRASQFLSEELPVRLAHRVEELRKLPDGLNDMPSIKKVRDWYAQSFEEITTLPRPNLDSTTRDRLLNPPKKQSTKLSATTRNPSLKDDGNGKSSMNSRRYFAALDDGKEWPPVLSEYNRKFARTLEMIKRRHDPVVTTVAQGINEWKRKQQRMQIDSSIQSFLDRFYMSRIGIRMLIGQHIALTDQTTNKHPNYVGIICTKTNVRELAEEAIENARFVCEDHYGLFDAPKVQLFCPPHLNFMYVPGHLSHMLFETLKNSLRAVVETHGAEKDEFPVTKVIVAEGKEDITIKISDEGGGIPRSAIPLVWTYMYTTVDTTPELDPGFNASDFKAPMAGFGYGLPLSRLYARYFGGDLKLISMEGFVPCLPPGRSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHW5</accession>
    <name>A0A1C1CHW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="6">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_04008</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHW5"/>
    <dbReference type="STRING" id="86049.A0A1C1CHW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04008"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08267"/>
    <dbReference type="eggNOG" id="KOG1351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="8">
        <location>
            <begin position="143"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="10">
        <location>
            <begin position="376"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT48115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="507" mass="56184" checksum="DAB65D0E9505D9E2" modified="2016-11-02" version="1">MATQDPRMASVKPRLKYNTIGGVNGPLVILDNVKFPRYNEIVSLTLPDGSSRSGQVLEARGNRAVVQVFEGTTGIDVKKTKVEFTGHSLKIGVSEDMLGRIFDGSGRAIDKGPKVLAEDYLDINGSPINPYSRVYPEEMISTGISAIDCMNSVARGQKIPIFSAAGLPHNEIAAQICRQAGLVNQPTKGVHDGHEENFSIVFAAMGVNMETSRFFTRDFEENGSMERVTLFLNLANDPTIERIITPRLALTTAEYYAYQLEKHVLVILTDLSAYCDALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIFVDRGLHNKGVYPPINVLPSLSRLMKSAIGEGLTRKDHGDVSNQLYAKYAIGRDAAAMKAVVGEEALSSEDKLSLEFLDKFERQFISQSPYDKRSIFDSLDLGWNLLRIFPKELLNRINPKLLDEFYARKGHGKKANKDARDNEDGNKQVNGDTNLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI85</accession>
    <name>A0A1C1CI85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_04239</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI85"/>
    <dbReference type="STRING" id="86049.A0A1C1CI85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04239"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08368"/>
    <dbReference type="eggNOG" id="KOG2827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024974">
        <property type="entry name" value="Sde2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13019">
        <property type="entry name" value="Sde2_N_Ubi_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650877" evidence="10">
        <location>
            <begin position="23"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Sde2 ubiquitin" evidence="11">
        <location>
            <begin position="5"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2-like" evidence="12">
        <location>
            <begin position="98"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="180"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="294"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT48220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="336" mass="36268" checksum="5A77BC2A11ACF6FC" modified="2016-11-02" version="1">MAPVVNVLLGAFPGLSLPSTLCLPLPASSTTEELLASITELLPPRLRESTRLILTSTSNRPICSSSTITLEELSASSACQQDGSSWLLPVRLSAALVGGKGGFGSQLRAAGGRMSSRKKRQNAELATGSARNLDGRRLRTITEAKNLATYLATKPEMERKEKEERRKRWEQVIELAEQREADMRAGKGQDGRRKGLSDEWVETKEEVGENVRNAVKMAMMAEEEKGRAKPSSEQEGESSGSGGSAAASEDDDSGDEPLMELEKDAMSLLKAEAEAGDADAIWVLENRLKIPAHLLPQPKPPVRRFVGFDDEEDFSSSGDEEPASGVGNGKQKDTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIB2</accession>
    <name>A0A1C1CIB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA repair protein Rad4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_03830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIB2"/>
    <dbReference type="STRING" id="86049.A0A1C1CIB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03830"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08397"/>
    <dbReference type="eggNOG" id="KOG2179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.290">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="512"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="572"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="639"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="778"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="834"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="889"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="950"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1022"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT48250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1069" mass="117665" checksum="E012C0A7ED5CCF06" modified="2016-11-02" version="1">MPPRKRAAKQPARTARQPASQRGKAKNDVPDVYDELLTEAAEQEYAAASTPKPVKQRPTQIAGRPEHRRGRAEHEIGGVYSDMLAEALAEEHAAASNPRPSKRRKTSEEPSSKIELDVNLFSAPTDGGIPAPVESEPARLQQVTLTEFDTATESDPEFEDVNLEPVVGEAEYDDEPDEKPLELNLSKISTPTRATPKRKPVSAAEKRLRLDVHKAHLVMLLANLKCRNQWCNSETVQAILKPLAQRKTTSLLHVDERKTQYERNQSFMKGIEEVFSTWKNLWIMDGRGMTRAYWTDDVDAVKESDDAEDLDFDDFKAAAISKRGSRDLAAQLFCALLRSLALDARLVCSLQVLPFSRVAKGQTPQKPKAEYIRAPPQDYGSTSGTSPQRRKVFSESMFPIFWVEVFSPAIQTWIPLDPTVRQTINKPKTGFEPYANDNYNKMTYVIAFEDDGSAKDVTRRYTQFYNSKIRKQRVESTPGGEKWWDKTMRFFEKPFREARDDIEDAFLQTRAESEPMPNNIEDFRGHSVYVLERHLRKNEVIHPRRESGKVKIGYGKDAKLVSVFRRRDVHVCRTADAWYRRGRDVNQGEQPLKRAVPRRKQTPATDDFDDDEDAASGTALYAEFQTSLYEPPPVVDGKVPRNAYGNLDVYVASMIPAGAVHIRHPLAAKAARILGIDYADAVTGFQFKGRQGTAVIDGVVVAMSMTNAMITVIEALESQASEEAEEARSKILLATWKRWLTALRVREHVQHQYGDREEGTKGKGLLVDDGDENDITYRPEDDGGGFMLEGAEPDESDEGATTALTPSRMPNLRPLELPLEVVHQEVIVVRSPHKLPQPPAQEQPMQQSNYQGNRSDVAEGGGFMLDNNHPTILAAEKLNSGAAANAESGGFVREDKVDDDNEGGGFLPDDTDEAGGGFVAETEASKAHAQASRTGEEQAGGFLLRPGTGAASANEAAAAAADHATASATPGGPGSNNMRHEYGDAGDGENPEAATGYSTGVGPSTAQPPPRPSPVRADEGTLNLNLNQNEASHGGSPASAPTPGSLLSHDPEEDDAEPEWLLNSLGEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIC0</accession>
    <name>A0A1C1CIC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Capsule polysaccharide biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04147"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08419"/>
    <dbReference type="eggNOG" id="ENOG502RHHQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008441">
        <property type="entry name" value="AfumC-like_glycosyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05704">
        <property type="entry name" value="Caps_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="45722" checksum="608B9FDDCBD9DBFF" modified="2016-11-02" version="1">MASTPKFNIPQEFQAQLLHIEPDDKRTNQEILVSLEQYTPITSEKNIWAYWDKGVRNMPAWCQRNVVDWVRICGPSWTVRILDTVPGSPTNALEYISADLLPEAFVKGTMTGVYTGPHSSDFLRGACLYSHGGVYMDTGNILIRDLDRVCWNQLADPSSPYEVCVPIMYATVMANHFVASRKGDPFIKCWHDLFIHLWKDRQNHEGLIYHPLLAFALTLTFEESQQANFKWDFKVAPQTVMEYISQVLSWQRLCMLEDAGDGFNATKYWLNKVLVYDSLQENWAAEATIGFGGPVLFNALATRLDTPKDSDEYKTAYKLVWRLLTKSTLQKITHGKNLTQTPAAGVLWEEPGNEDKDHEPGTFAELFRYGTVHFRQTRETIRYVKAEKPATTLKKGLLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIG9</accession>
    <name>A0A1C1CIG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trappc2</name>
        <name evidence="2" type="ORF">CLCR_04390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIG9"/>
    <dbReference type="STRING" id="86049.A0A1C1CIG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04390"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08404"/>
    <dbReference type="eggNOG" id="KOG3487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="171" mass="19294" checksum="E4B08346D073F449" modified="2016-11-02" version="1">MSYYFVIISPTDTPVFELTFGTSKAGGDGVARFRNAETSRYMNQFIVHAALDVVEEVQWLQPNMWLKVIDNYAPTNSHISCFITGTNVRFMLLHQPSTTTASAGSRTSTISSTSIPQNPTSPQTEEAIRQFMNEVFELWVKTLMNPFYTVGNQIKSPIFRQRVTAAGKKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ99</accession>
    <name>A0A1C1CJ99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipase 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ99"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ99"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04140"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10247"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF24">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="109"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="424" mass="47764" checksum="1B862FCC4A9991AE" modified="2016-11-02" version="1">MKHKYTDDHHPARAMFTQPFGVSWRKALVSLPRLVPDFVLNFTSAEGPQPIVFDIPSRGKHLIPLYVWVPPLRKHHRHGDKNAAGSHLNESLRPMGIDDNHAGKLPVLIDFHGGSFILGSCQEQAPFCSRMCRELNCVVISVDYRLGPYAQYPAANLDAEDVVLAVTDRTNKAYTPLREGIMWAMLKEGRNPVELDDAKIALSGFSSGGNLALNLVLSVKNDPTLETDWLSPLQWDWPTDIPVLLFYPSLDARLLPDERPRPEGLDPPTGFVERWRIERELMPTYLPLEKRTHPRASPGLADITAPQEGGKSGLHPRTKALLVLPQFDSLNSQSLLWVQKVHDQGRGADLSVEEVKGVVHGWTQFPDSWISEEHRKLKLEAFARARAFLFEWWQLDREKGDKVEVEVAGDKKDDVQVDVAGDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJB1</accession>
    <name>A0A1C1CJB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell pattern formation-associated protein stuA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Stunted protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_03926</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJB1"/>
    <dbReference type="STRING" id="86049.A0A1C1CJB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03926"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10251"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF15">
        <property type="entry name" value="TRANSCRIPTION FACTOR MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0183">Conidiation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="10">
        <location>
            <begin position="6"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="262"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="104"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="431"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="485"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT48599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="669" mass="74721" checksum="273F31BCB5496631" modified="2016-11-02" version="1">MADRDIYSATYSNVPVYELKIGNDHVMRRRSDDWVNATHILKIAGFDKPARTRILEREVQKGVHEKIQGGYGKYQGTWVPLNEGRLLAEKHDILDSISRIFDFVPGDRSPPPAPKHTTAASNRPKPPKQPAPPRKVHQQQQQQPPPQLQNSLPIQHHYPAVDSYETASIPYNGTDSRDPTPETASFIAEDDFLPMSQTSAASRKRKRDFEELPQTVSELEHTMYGDELLDYFVTAGDDPIGSNILPPEPPLNFHVDRPIDNLGNNALHWACAMGDVVVARDLLARGANPAAPNSSSAETPLIRAVLFTNNYDKKTFPKIVGMLAHTVVERDTYGATVFHHIAESARTRSKWNCARYYCEVLINRMQEMGSNYVQALLTSVDHNHDTAALCAIRYGCVKVATFLLNHCPEAGDISNLKGETANDYLRALREKKSLKQPGSSPPRTGEPVSSKQSRRQRQKESVSRAASMVLDKIGPLMDEGSGKLADLYNKQMAEKDTEIAEAKQALTELENQRHKVRQETFSVMARAEDASKIPALRQEYDMCLNEMESLLENKEHITLQTEIFLQDQLTSPEAFRFPNIHPLSPDEIHAAAPWAVELNTQQQIRRLWVKEVAKLMGDAGTGGRVGKHRRLVALATGLKEEDLDAMSEELLESLQGNQPTGGAPHTPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJD2</accession>
    <name>A0A1C1CJD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJD2"/>
    <dbReference type="STRING" id="86049.A0A1C1CJD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04400"/>
    <dbReference type="OrthoDB" id="4120486at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15245" checksum="32E6219CD82DCEFC" modified="2016-11-02" version="1">MISQNLNTLSNRLDQHSNNITQRLNAIDTKVDRLSQRVDTLAQRFDSVDVRMDSDRHNNWARLQNAKITSLHANLVPLHDRNNQLIGGFPGDMTAIEALRLHELGRILQALGSDIEGRSSQEKTTALRIAVGLDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJJ0</accession>
    <name>A0A1C1CJJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_04650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJJ0"/>
    <dbReference type="STRING" id="86049.A0A1C1CJJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04650"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03204"/>
    <dbReference type="OrthoDB" id="4121255at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT48694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="74764" checksum="EC70FA9438BA550E" modified="2016-11-02" version="1">MPAKGTSYQLDASTSSTRSVNTKKRLHEDEVIPQGDIQESGKSSKQQRVENLSDGPCNLLDTAATSPCSSTKSSIPKPSPTAQAEVNSRNGPEPFPIETRPYRLALQDLEKVLKSRSLPSTHGAAHVDKKKPVGWCNCKTGGDELDAVICDNPDCETIWYHVRCLSKEVQSFSERFNLWLCSSCFIKSKNQHEKKMRELAAKDRKRGPHSLDDPNRQDSVRDRDSSVVPSIEVDDSTTARKNPSEQQPETTTPPSSSVETASANSPHFPRETESAATPAPLTLLKEDEHDDEPPNASAQITQADNLSPVPTQSLQAQRSELCRQNGGREATGLDVVERVSEEQSQNIDEHQRTSTPQSERTLEDDHTSSSETESCHSRDSQDVQTQGSSMQARARRRYTNFIHRDPEVFGLAYRVTNHEKISASAKSWTSSESHCIDKTMTEEKCIVIRYLHGEEVPVPVAPPGGSEAFLHIRCCRENDFKSRHVVEVPVRLLMMFSPALNGFDIFSNASQLFDAAPGTFVGTIDVGRIDKGVVESAVTFLKGGVLEVRLPALGQHISYAEKKALLQTADLAHKLDIICLQKAAMHAICVSVLREQTDWDNEETRLLLQTATWERNPARDLDKIIDSGLIENPHVLPMLACEREDRRELCAMSAVCFGLGDRIQLDPEIYEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJX6</accession>
    <name>A0A1C1CJX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bactericidal permeability-increasing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_04630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJX6"/>
    <dbReference type="STRING" id="86049.A0A1C1CJX6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04630"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03129"/>
    <dbReference type="eggNOG" id="ENOG502SIPH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5407957at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027842">
        <property type="entry name" value="HAM1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF4">
        <property type="entry name" value="DUF5923 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14613">
        <property type="entry name" value="HAM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="4">
        <location>
            <begin position="28"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like N-terminal" evidence="4">
        <location>
            <begin position="199"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like C-terminal" evidence="3">
        <location>
            <begin position="597"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT48777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="84337" checksum="165C5CD756500961" modified="2016-11-02" version="1">MSFIARCCGYGRKRGGDDTEPLLPRYEDDTARERALHQKLHTYQMLRALSQGYMPSNEQTIVNLRTLLASDVLNPNNKDLSDSGRALIRNCRSWIKLFIELLKNKNSQDEIQDFIWYTTKSRISVDVDDIAYSASKVKARADAKAAYESFRTVGSLLLTNADFRLFVNDIATIGREVLADAAFSLSSAAEKTGKQLELSEQEQQTVAKPGADENSLPSKQELQENAEDTTKMIGSEVAKVGQDAIESAKEHFSGSQKDTLLYRIKQVILRLRSRTDYNDSVSTISKLIQRYAIAYSRVADTAVSTAQEDVNTNPALDRAVRNFWGFVSSFGDPKAWEQLEQDFNKVMAHAKSDPQFEKFMIEIGNAVQRMLTDPDFFDNADEKLEELKEKSSKLGNESEFRTDFDKMLRQAQVTINSVIEDKDVNGLLLATKRIYNILTPPNKITNPDLITDSIHIFLPLLIRSVQYIPIPRVEVSVPEMDLLLENLVLEPGRNVNSTSFLPYRLLVSTKNDIEIRKTHSRKTVSTTKSLVTISINGLSVAAQDLGFWIRGHAGLIHFADEGIASFYLDERGIDVSLDLEIGREKLEQILTLRGVRVHIHKLDYDLRKSKLSWLGWLFKPLLKHLVRRSLEKALAENIVNALRAANRELVFARERLRATRIADPQDVVTFLKAVMARLTPAEDPDLYTRVGVDAPKQGVFKNRYTPGSIVKLWHEEALRAEEAVQDGEERGGGWRNDIFDTPVQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK20</accession>
    <name>A0A1C1CK20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK20"/>
    <dbReference type="STRING" id="86049.A0A1C1CK20"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05309"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03031"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="77" mass="8781" checksum="06FFDCAC542727A5" modified="2016-11-02" version="1">MPFFSKVFKSREGQVKKNAAPVANGDSHKKPQWSDAWVRTRVDPEEVAELLHLCTAELKSRGRPPPCRECRLNAHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK31</accession>
    <name>A0A1C1CK31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK31"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04933"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03029"/>
    <dbReference type="eggNOG" id="ENOG502RPN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5409186at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650850" evidence="2">
        <location>
            <begin position="21"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="320" mass="31726" checksum="31D63FBA9AEF8C5F" modified="2016-11-02" version="1">MFLPKAAALVFSSLVLLATAKPSESDASAKGLSPNPGHGRTLNPSSAKLMFKRDLTKRCTGTCEECFGDGYTLCPGSAIYCYLPGDSSYGLDSCSSDSSSSSSSDSDTSSSDSTGIDDLCYQVGATCQSCFGSSYLECPDGYHCYDPTDPQYDTCPDDSSSSSGGSSSSGGSGGSSTSSGGTTTTTSSCAATWGEGNIPCGSDGCYNPDIGESCCAGGYYCDAGYTCSSTRGKCSPDDDDSSGSGSGGSLLTATTSSPTSTSGLLNAEATTATTTGSFGSSTTGVSQISNSDTDSSDANGLVVGRGLLVVAAAGLGVLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKQ2</accession>
    <name>A0A1C1CKQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_04619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKQ2"/>
    <dbReference type="STRING" id="86049.A0A1C1CKQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04619"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02854"/>
    <dbReference type="eggNOG" id="ENOG502SHVI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="284"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="669" mass="74381" checksum="88C55118F1138FF1" modified="2016-11-02" version="1">MQSLQKAKVNVTALYAPPNVRDRVRQLESQVDFLMGALKQANPATTLDYAMSGSQTAGPSFENEEEGVSDEELALDPDSAGYIQFSHSQTTYVAGGHWMSILRKIPELADVFGSDFCLDKDAGMPAEGEDDGLALTGFHERVDRQHILNALPSKDFADSLVAVCFTNTNNEAMIVHPPTFRKEYERFWADPTSTPIIWVGLLFALMCLAVQYQQYSPDEARRLQVIESDPENLLRLYRTRTIQCLILGRYSNAPPYAVETILLYLLMETLGRQSMQNLDGPLIQWGNLVRIAFKAGYHRDGSNFPGISCFQAETRRRVWAILMGWDLYLSMQFALPSAINLSLCDTKEPRNLGDEDLYEHMVELPPPRADSAHTLPQFHVAKNKLLEIFGRINDLTTSVKSSPSYTEILKLDATLTNTYESIISVWQPQHQPQDSMSTSSRAAPFISVAYTFLAFIYYRARIALHRKYIAPGRRHKQFTYSRKVGIEAALTILQHQWVLYLETQVGGQLCRHGWKFLVLLIQDFLYATAILCVELAEEVSLTDLGWASNGAPASEDVGNAGTHMRDRVFHALSSAYIVWLQSKESESSREVKLVVASLKHLLSKAQEAGVGQTTMIAPTAPAVLPKPGADAYMVESGSTLAGQAPSPSASTAATPQSDGIYWGIGHFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL37</accession>
    <name>A0A1C1CL37_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL37"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05162"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02715"/>
    <dbReference type="eggNOG" id="ENOG502S7FQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2253354at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035213">
        <property type="entry name" value="DUF5321"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17254">
        <property type="entry name" value="DUF5321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="212" mass="24757" checksum="4BF470BFA56E8319" modified="2016-11-02" version="1">MRPLASCNARTSRLIRLPSVKVFPPRPRWVQRHQHTASESRLPRLAQPGFWDLIIPKSLRGHFTRPGSAAPEKPTNPATFFIWIYILIGSQAIRIMSLKNEFMAYSRKADVKIQQLREVVEKLQRGEEVDVEKILGTGDETQEREWEEALEELQREDRVWQENRERSREDKERLARKEQDANPVNDAQDKPDRTNPLLSPDVPLVARRPGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL41</accession>
    <name>A0A1C1CL41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pheromone-regulated membrane protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">AFR075C</name>
        <name evidence="10" type="ORF">CLCR_04603</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL41"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04603"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02751"/>
    <dbReference type="eggNOG" id="ENOG502QPMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="626"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="711"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="356"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="635"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT49181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="798" mass="87086" checksum="2B5E4BEB267CEC85" modified="2016-11-02" version="1">MAIGDSNSDQDQYGNIDPSRLEAGLNDSHNTNRRANDSHISSGTDVRQTIGVGDHGGEGGRYPTSGPSSENNVADEASPPQRPRPAWSKVINWVKQKEHDRPFRLANLRPSTSFYTKFDEGSSADQEKPSGDDHVHEYPQEGGEDGEAKSQVYTQAAAETVHTFLRQNSAYQRGANLDYEERSVDQHVYDVDYVPAPEQYKPGLFGALLAYKLNHLQQDWSNNQKQPQSRPGGQAKHDPKGHQYSQSLTTSLPTSGTATPSKKVKWYEKPEQSNPTAAALMQAALSSTGPSVAGMGAIPRPRPVRPKSADMISTAVDIITHGKHHHNRHSGAYSTSTLENHVGLITEVADIIARRDYLIKLCGAFMEYGAPTHRMEEYLGASARALLIDADFLHIPGAMICTFADRTIHANNVDIVRKRSGLDFARLKDVFNVYKCVIHDKLTAEDGIREIDNIRRRPDNYSELFRILMFGVASVVVGPFSFQTRPIDFGPIFLLGCAIGFMQVKIVPRSEHFGNVFEVFACVFAAFISRALGSIQYSDGQYIFCFSGMAQSSIAMILPGFMMLNSALELQSRNLISGSVRMVYVIVYVLFLAFGLLIGTTVFGLIKRGAVSSTTCDIPPWFAAEMNWKLIHTRFIWAPLFACCVGLIYQARWRQLPVMALIAVCGHQANFWISTQLSSNAQVANAIGAFVIGCISNLYSRLFHGLAATAMLPAIYCQVPGGLASSGSLVAGVVSANQISGNSTASAQNDSGNGFSDGTIFTVGYSMVQVAIGISVGLYLSALVVYPYGKRKSALGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL78</accession>
    <name>A0A1C1CL78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">30 kDa heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_05168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL78"/>
    <dbReference type="STRING" id="86049.A0A1C1CL78"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05168"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02731"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="38"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT49202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="168" mass="19234" checksum="C04CA5C1AF053798" modified="2016-11-02" version="1">MAYAYYYDYPPPLVDNPHERHHQHQSLVQYLARRHPRPEDHPNQPDVDFRDAIKEYLIEVEVPGIKKPDEITVTWTGHRALVLTGKVERPDYGAPENAKVEEEQAEHSAGGVHLLVGERRVGPFRRYINFPTEVENVSVTLEAGLLKIRAPKKGFSEVAKAKVDVKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLI3</accession>
    <name>A0A1C1CLI3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sexual development protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLI3"/>
    <dbReference type="STRING" id="86049.A0A1C1CLI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05001"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03282"/>
    <dbReference type="eggNOG" id="ENOG502TDQ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650895" description="Sexual development protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="35819" checksum="BA2559F824B5BE09" modified="2016-11-02" version="1">MSSLLLPVALSFLARSVLASPVGIVTGTALPPNIAHQAGGGLPNQPGTPKISLNAINSFHLANFLENLESHFFQEGLMNYTRWGTGDQVNGVSNMAVVSRIAAQEEVHVASIVGLLEGNGAPAVAPCQYDFPITDETSFLALASIITNVGIGALQDLADGLSTTDPGLEATVASIIPVESRHDAFFRLFAQEVPNPTTFETRISGIWAFNLALDFIIPGSCQDLPSFITSLPIFPDLGIIGYGGPSFATPNSPGKLIFQVGQPDMLPQGWNSGPLYMAWVNQDNVPAYTPVTVQGNELHADVQPGMFGVAFAALTNQNTATNINDLTKATLAGPLPVPLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLJ2</accession>
    <name>A0A1C1CLJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05307"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03276"/>
    <dbReference type="OrthoDB" id="4141480at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="80" mass="8978" checksum="2065F96AD763D6D6" modified="2016-11-02" version="1">MQAIYKDLYPSPESDPAEEDVLVQKRMEVAKSAPRLEREKKCFTAVNEQAAKEREEAGVKARDFAHALPVGCRSKCQKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMG6</accession>
    <name>A0A1C1CMG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_06911</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMG6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06911"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09944"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="62"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT49698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="507" mass="56995" checksum="C439EF0A64351BD4" modified="2016-11-02" version="1">MSSLPHDVEIQDGDRFSHEKDQEVRIERSESLDGLPDPDAGKSDEERKKIDRALMWKIDRWLIPWLCLLYLLSFLDRTNIGNARLAGMEDDLGMAGHDYNNTLTIFFISYALAEPITNILLKRLTPRIFFTGIIFLWGLIMTLMGLVQNYAGLLACRWFLGLAEAGLFPGVNYYLSCWYKRTELGIRAATFFSAAALAGSFGGLLAAAIAQMDGLGGKPGWAWIFIIEGLATMFVGGFCWWMVFDWPDTARFLTPDERIRVRRRLAMDKQASSAEEYDRRHILAALRDWKTWGYAFIYMGCLCPLYAFSLFLPTILRGMGYQGTRAQLLSVPPYAVAAAMTIFIGWFADRTRWRGYCNMAVVSCGIVGFVMLISTEDPHVQYAGTFLGAVGIYPTIANTLSWAANNIEGVYKRGVVIGIVVGWGNLNGVVSSNIYITGEAPRFWTGHGVVLAYQVICLLGGTIFMHVMLRMENAKRKSGKRDRMHEGKTPEQIWVAGDNRPDFIYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN46</accession>
    <name>A0A1C1CN46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA-specific permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UGA4</name>
        <name evidence="7" type="ORF">CLCR_07221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN46"/>
    <dbReference type="STRING" id="86049.A0A1C1CN46"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07221"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08843"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT49926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="406" mass="43818" checksum="621EFDA27D25F268" modified="2016-11-02" version="1">MFLSVIVIARDGNWTPSNGTIYGVFVATVACHGLIASTMARVMGKMQTVFVVMNFVLIFATVIALPIGAKHRLNSASYIFTRVENLTTWPSGWTFMLSWLSPIWTIGGFDSAVHISEEATNATKAAPFGILFSIGSCWVFGWICCIVIAATMVHDVESLLGSPFGQPMAQIYYDSLGKNGALGFMALLMIVQFLMGISILVAASRQAWAFSRDGALPFSSFFRHISKKFGYIPVRTTLGCAFLAAILGLLCLIAPAAASALFSLAVAGNNLAWGTPILCRLVWGKHKFSPGPIYTGRASIPLAWMAIVFLVFGILLSMFPVGGPNPTAETMNYTCVINSAVWGGALLYYFIDARKWFRGPQITIDLSQLTEEQEAALREEGLKVATDGTAVVGRNSTDVTEAAKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNN3</accession>
    <name>A0A1C1CNN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mxr1</name>
        <name evidence="8" type="ORF">CLCR_07614</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNN3"/>
    <dbReference type="STRING" id="86049.A0A1C1CNN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07614"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08988"/>
    <dbReference type="eggNOG" id="KOG1635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000006">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="7">
        <location>
            <begin position="40"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="207" mass="23479" checksum="3CFF8DE6CB679F55" modified="2016-11-02" version="1">MAFSMPSFLTRFLRPFSSTQLSLQPDALSAMQFPPTSQRAIFAGGCFWGLEELYRHHWGGGKGLLDCRVGYTGGTTKAPTYEDVCSGRTGHAESLLVVFDPDVVTYRQLVEFFFRMHDPTTLNRQGADTGTQYRSAVFAENDDQLKIAEEIKQKVGEQWYKGKTITTEIKRATQWYDAEGLHQNYLLKNPSGYQCPAHFVRPHPELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNR2</accession>
    <name>A0A1C1CNR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_07785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07785"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09050"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT50140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11736" checksum="3A7E4638918C3DC9" modified="2016-11-02" version="1">MFQQLGEKTLYIFAACNAITIPMIWALYPETSQRTLEEINLLFASDSIWNWEAEKTLALLREQGEVPERRQSVLSAKRLGSSSAGTPRAGLHQSDKSPNVGVEGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNX5</accession>
    <name>A0A1C1CNX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pru domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_07158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNX5"/>
    <dbReference type="STRING" id="86049.A0A1C1CNX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07158"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05776"/>
    <dbReference type="eggNOG" id="KOG3037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="7">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="410" mass="44005" checksum="912C227CA2AAE8EB" modified="2016-11-02" version="1">MSISPILTFKAGLCDFDTSSSPAKVKPLPTPGYLYLYAEDELLHLCWRPRDAPSDEPQLDLLMLPTDGSFTPYHPTSAANPSNTKKATNGRIYVLKFTSSSQRYLFWLQSRSQHPQGDPSWFSARDLKLGQIVNNLLQGEEVDVEAQMASIPRDQNNPDDDDEPMEDVEGTNHDRNRRPSHGGGGAGPDATGGDIREEGEPSREGGADGGRAAAASGDASSLVQNFLRAMQERNQGGSGGGGGGGQPHEQLFTTLADLLTPASTIPLLNVADDGLIDRLCECLPPQLVATAQNSVDTSALQNPNSSAEEKQAAQRALTVARRDMLRRVLHSPQFSQSLASLTVALREGGLPIIAETINIPVRNGGYLRHGGVPMGGGEAVEAFMEGVRKDVEDKLAEGEDDGRGDRMEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPI4</accession>
    <name>A0A1C1CPI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ubiquitin homeostasis protein lub1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lub1</name>
        <name evidence="9" type="ORF">CLCR_06676</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPI4"/>
    <dbReference type="STRING" id="86049.A0A1C1CPI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06676"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05606"/>
    <dbReference type="eggNOG" id="KOG0301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="235"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="7">
        <location>
            <begin position="373"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="8">
        <location>
            <begin position="500"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="462"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="805" mass="86795" checksum="94687C01B17E2E27" modified="2016-11-02" version="1">MSGGTSDYKLSAVLSGHKSDVRAVLLPDPSFAVTASRDGSTRIWKRTSIPLPTYDGTESSHGAQFKTCLAYVPPSKEFAEGLVLSSGQDALIEARQPSTTTDMNADAFMVGHSNQVCSIDVCAQANYFVSGSWDSTAKIWEIGRWEVAVDLAGHTATVWSVLAFDGETAVTGCADRQIRVFDVRGKLRHSWDAQDIVRALAKLPEGHHTGAAIAAATNDGIIRLWTLRGDLVTSLIGHESFIYSLAVLPSGQLVSSGEDRSVRIWEGQNCIQVITLPAISVWSVSASPNGDIIVGTSDKLARIFTRDSERVADAETLAAFEESLQASSIPQQTIGQINMTDLPGPDFLKRKVGTKEGQSQIIKEDDGSACLYQWSTSQQQWIKIGQVVDSAASSGKTAYNGKEYDYVFDIDIEDGKPPLKLPYNINQNPYDAATKFLQDHELPMSYLEETANFIIKNTQGATLGQQAPTSADPWGTENRYRPGDAPTSSYQPPPPTQTKQTLPQKDYLSVVIGKPGAAMAQINKKNADYSGSEIALSPDEIKILSDVAQQLEKYNFSGKASLPGSPTISTAVSILAKVVTRWQPPANRLAALDLLRFIAAAAQEFPSSGADSFNTVVGILNSGIFDERFLRDNNKLAMISMRFFSNLLYGSSTGRRLVKGNLEGIVESLKPVAQFASSDVSVAIALTTLYLNIAVLITTSAGESEANASHALELLADLTNLLASFPAVNHSAASSNPASQSTEPAYRSLVALGTILVFFKGDSELKSAAKDIFDVPSTLGKLRQGRYLDEPRFRTVAGEIEQTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ36</accession>
    <name>A0A1C1CQ36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ36"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06869"/>
    <dbReference type="OrthoDB" id="4161771at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="61842" checksum="A84D51FA372C5515" modified="2016-11-02" version="1">MFLSMAAAYMAHGSHTPQDGVAVSDCWERMISASPLRLARALPASCSESAALFGKATLSTQSEDPDKLKRPEAMDFYNWFSLTSTLVLHQANMPGDGGYTNSTGVDYSPPSPAYNSSGPSRPLTPVAHDNSSPASALKPATSVKEACPEDTTSQSKIFDKPPPTAPRSMRQNTSPPPQPLRRVGSYRDATPHRSERSESYRPCQSRYGSDLRRPERAPVANSYQALSPHRPRMSWADYKIGAPSTDVRYLRYLEDALERCNSPRTDHVNQSSRGMDGASLANSAQQVAATNPATGPSPVEDAVSKEHETVTVVGAKARQDVHTSSPVKAGVGETGQDTTTPPDKHGSREDNFSNRDYTDRQQLESRAQEDMQKGLGLPQPKTRLNESSRHDTYPSQDCRPSVHPGVRDDVAVRERGKHPLPTKPPQSQPNLGQQMDGMAHSSTSHAAHLHNSTPYMKSHLSGPSKAQLSRTDPGMKPFKSAQMVNKADKYKQITCPSWNHSGCRLIEAHCIFAHKTTGRVAPRGNETEAKDFTCPRWREDSCTRQTWEYCPARVASTPMQRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ44</accession>
    <name>A0A1C1CQ44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_07560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ44"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ44"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07560"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05413"/>
    <dbReference type="eggNOG" id="KOG0015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="51"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="207" mass="22444" checksum="BF38FEEB2D80FEA3" modified="2016-11-02" version="1">MADITDPSGGLEHPSPGDDLAGNGVDSRGTKRPRASMAGDDDDDDDEKGGRERRKIEIKFIQDKSRRHITFSKRKAGIMKKAYELSVLTGTQVLLLVVSETGLVYTFTTPKLQPLVTKAEGKNLIQACLNAPEPSGNENGVDATDDVPSPEDVPPMPPAAGVPRAAPHTGYAMTPEQQQAMYYQQMQQQNQGGQYGGMPQMPQHQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ45</accession>
    <name>A0A1C1CQ45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_07774</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ45"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ45"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07774"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05421"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="113" mass="12085" checksum="CF773C272128134B" modified="2016-11-02" version="1">MLPPGIPVDVDADTSIGEKARISAAGGFVDFGRVNGNLALSRAIGDFEFKKSADLSPEQQIVTAFPDVITHEISPDDEFLVIACDGLSSLFDFDGGRRADSDQESGIASRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ64</accession>
    <name>A0A1C1CQ64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Metal tolerance protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MTP4</name>
        <name evidence="10" type="ORF">CLCR_07080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ64"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ64"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07080"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05364"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05365"/>
    <dbReference type="eggNOG" id="KOG1485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000001">
        <property type="entry name" value="Metal tolerance protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF13">
        <property type="entry name" value="CATION EFFLUX PROTEIN CYTOPLASMIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="138"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT50647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="458" mass="50536" checksum="8E4F2A07F2DAB6D5" modified="2016-11-02" version="1">MSSSIESKSQDHIVQEEAHAGSTALAGGPVQQPEDGPAEEVISASAGSGHLPKRLEPSNEEQSTSSRDPYSLQGYKVDSVGLGESNSKLPCRRQTRVKKYYNRQNALIDAYLGSNDEEALEAEDNIKNGGKVRFAVNASFACNFCLFVIQLYAAISTGSPALFATAADAFMDLVSSVVMLITSRMGARPKLAKFPVGRKRVETVGIILFCALMTTVAVQLIIESARALGRGAPDTESLAIIPIAFVSTAIFSKACLFVYCFLLRRYPAARIFMIDHRNDIAVNLFGLTMSIVGSRFNKVWYLDPVGAICIALLILWSWASTAFEHMWYLVGKSAPQDVLNKLVYVSVTHDARIQKIDTVRAYHAGEKFYAEVDIVMAETEPLKVTHDVSQSLQRKLEGLADVERAFVHVDYEAEHDVHEEHRALYKRPGKAAEQRVEDATGRLEDEAKKGVFARLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQA5</accession>
    <name>A0A1C1CQA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_07797</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQA5"/>
    <dbReference type="STRING" id="86049.A0A1C1CQA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07797"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05338"/>
    <dbReference type="OrthoDB" id="4133109at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="10733" checksum="32A19EB37D3EC2E8" modified="2016-11-02" version="1">MPIIGTCFFAVGALVIVNAVLSYLPDAFPTEIPSVMAGSAFMRFSFGAGFPLFAPAMYHNLGIHWASSLLGFLGLAYVPIPFLFYFVSIHPPVSKAWSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQI2</accession>
    <name>A0A1C1CQI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQI2"/>
    <dbReference type="STRING" id="86049.A0A1C1CQI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06712"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05290"/>
    <dbReference type="eggNOG" id="ENOG502QRU3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000202">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding" evidence="2">
        <location>
            <begin position="365"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="746" mass="83432" checksum="5BE605503F101B10" modified="2016-11-02" version="1">MASRYLSDSKRQHSPINRPQSSSPGTAARAGAGAGAGSARAKQAADCVQHQRVHRFPQRSASYSQRQPGDGDSPPRHPSPHIKQEPGSPYNTAATRPSKRPALDDEFRPSKIGPGSASPEYSSGPYENPLVLPLDIKRPGSPVSPRLSLQQFFSSSRQSTQSPYGQEVDRKFFDPAPGSPLQPDHDVQYEDTGMLLQPDTRPISQEQLVNEVKGIYAGLVMVEKKCVEICQQQSQSTVKLSNEQWQALIALHRTLLHEHHDFFLASQHPTASPALRRLPTKYAMPARMWRHGIHSFLELLRHRLPYSLEHMLSFVYLAYQMMALLMESVPAFHETWIECLGDLARYRMAIEEADMRDRETWANVARMWYNRASDRSPDTGRIMHHLAVLARPNIVCQLFYYSKALVSVNPFPNARDSIMLLFNPLLEAYGLPSENPKKEAIMSKYSKFDYSLVTAAGTLFTKGLIHDYCVHVYLFASELDNHIARSGSNWKVQGTEVASASISWILDFGSDENFLWAAFRAHHDKLRGSQPELLPANAASKIDHIAKEDSHRKFWINNEISAADFRQATPSAGDQPGVKFTSSDQVTSYAIPVWAHIVAIVASKVGDRNILPFLHVTLAFLWSLSYVPGGLIYLENDIPWAKLVLSLNTLSRSGVVDARVESSEFPQQQSGTGRQLPEDFLIRGLVWAPFYFPSDFFEGQVVDEDERTLELPSHAAPRAERCIWLGARLASVCLAVCAHTSPLTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQU2</accession>
    <name>A0A1C1CQU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase CHIP</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RING-type E3 ubiquitin transferase CHIP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">STUB1</name>
        <name evidence="14" type="ORF">CLCR_08857</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQU2"/>
    <dbReference type="STRING" id="86049.A0A1C1CQU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08857"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09499"/>
    <dbReference type="eggNOG" id="KOG4642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16654">
        <property type="entry name" value="RING-Ubox_CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045202">
        <property type="entry name" value="CHIP_RING-Ubox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7 11" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="213"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="140"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT50853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="289" mass="32720" checksum="3159BE83E72EAD17" modified="2016-11-02" version="1">MSQPASFKDLGNEHFKAGKFKEAEQLYTQAIAEHSRSDPKVFGNRALTRIKLSDWPGAESDARKAIELYGPGNKTNLVMKAHFYLAQALLPQRHVGEALDEAKIAYTMCIEIQDPSADLIGTFILKAKQAKWQAKETARLRELNETLALVEDLLDAQLQRDIDTVEERFKNGDIGETGRREEVEELRNEAEVRRANIRRGFEDSKRPETVERVVPDWLIDPITFEVMHDPIVTPTGVSYERASLLKHIKANGCDPLTRQPLRADQLIPNVALKNACSEFLDKNGWAADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR61</accession>
    <name>A0A1C1CR61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR61"/>
    <dbReference type="STRING" id="86049.A0A1C1CR61"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08815"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09636"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="329" mass="37252" checksum="1F67A75204794542" modified="2016-11-02" version="1">MDKLEKKTLDVSRGFTYTYYTSPAKDKKPTLLLIHGFPDAPDTFEEAIRDYLLPNGYGIIAIDCLGYNGTSKPTDTESYNFQLMAQDIKEIVDKEGLDKVVPVGHDWGAGVAQRFYNFHADRCSGLVLMNVSYLIPTPDQPFSLDGVLQFTEGIFGYGIYWYWQLFTAEDGAEIMGSHLDSMWDVAHGAPETWLDTLCKKDGVRDFILADKRQPTMAYATEERKQKWIASFKEAPGFDAPLNYYRAMVSGVQDEANKHIPKENIPINVPFLFFGGQRDYVCRPEMLQLSLDAGLIPDCTKVVIDSGHWAHLEKPKEFGEAIVGWLKEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS13</accession>
    <name>A0A1C1CS13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS13"/>
    <dbReference type="STRING" id="86049.A0A1C1CS13"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07946"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06790"/>
    <dbReference type="eggNOG" id="ENOG502QVCT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="895"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1092" mass="117177" checksum="A5C7073F6DBB3AEA" modified="2016-11-02" version="1">MPASNKAVCTADSKHPDIGDPKAVAEQDTIPSRAGKKKTKNAAARQLSSVDNADNSTESASMGQSQLPSSSSNPPPSILGQIPQTFSQTRRSNAFDALNDTNASQKVSDEHTPPVDLWARNAVHGRTPPVEPIPGLNSSSSPPYEPGFSTRVAFNARSPPISPPMRNARPVSYGGGIPALPSHHRMSTSPYGYGMTAYGSPPVLPHLPQQHFYGAHDVDLGVGPPHTPLPEPAPLKFVRLPGSGSELRDAILLTVDGELHLVSYNGEKLEHIGALLGVQGTIVDATLLPWNTGEDPFSTLRPLVALVVHGSGAPHPGTPPTEDRPFNGTPYNVPETRVVVFSLSKSCEVAELLRVPTATGGFPGVATSSGRPSTLKIHASGNFVVVSSGESGEIYVFALRRGKDSGVFECLGKYWTTLQPHLQRRDSSSYGPASDADISPADLARGIDAENPPILSLNGRWLAFCPAGTSSRRSIGAILGEYVVFGKNSNVNAGTAPARPLSNCEVDSPDVDTFLSKVAKGFAQEAVRGAKWISEKGMQTWQNYWKKDTGSPSQPALQSSSPPAYSPHLALAQFPPTHAIEQQGVSRDPELVSILDLKMLQESQGRKGAELSSVTTFQPPGGCSFLSFTPTGLGLLTANHNGDVQYIWDLMQMKYTHGSPTSTSTESNRVRQIARYERLSPSTIVDIAWDGPTGYRFALLTKNRTIHIFDLPKTSFRWPPPAVKKSRPTSAPIDPAQGKMGHDPAPAGGFLASAMSLAGRTQPMLASLRGRAPSINGGLAGATPVGIGFASTTSIKSGGRAVAAGLSKSLGAASETVTSIRHANQSRLHLRILARSGMFCWLRRDGRSILSILDDNNVKNYYVRMTKPRENRQLETVSVFDARKAVATKLPKAVDLTSGRPPTAFPAESEDKSNERPPLLGFWKPRPGRDVGSRTPHPLASAEIETNAPYQPFHSDRRVTISFNSGQATSVIEVRPSTHQGRRSSPESSDRWIFGEDISFSTQSIIKPNPKDADDSTTIQRQTTIVSAHTNLDTAPIQAFDDDIPQVFSSTKKKKGKKINRAQGRLLEEPEDNTVTDVSFDPGEDLLGEDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSW3</accession>
    <name>A0A1C1CSW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Embryonic polyadenylate-binding protein 2-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_09259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSW3"/>
    <dbReference type="STRING" id="86049.A0A1C1CSW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09259"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06514"/>
    <dbReference type="eggNOG" id="KOG4209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="67"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="112" mass="12641" checksum="7D4EABE7E9FC91CE" modified="2016-11-02" version="1">MSDTQDVRDEPKDTHEDGGEEEEEIAAMKRRVAEMESEAAKLREMQSHLEQSSESVPREDREDVDARSIFVGNVDYQATPEEIQAHFATGPGTINRVTILLDKFTGHPKGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSX3</accession>
    <name>A0A1C1CSX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09110"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06489"/>
    <dbReference type="OrthoDB" id="5596743at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058645">
        <property type="entry name" value="NTF2-like_dom_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26534">
        <property type="entry name" value="NTF2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651024" description="NTF2-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="NTF2-like" evidence="2">
        <location>
            <begin position="39"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="198" mass="21216" checksum="56EA5F62415C37FA" modified="2016-11-02" version="1">MKTLSIISSLAMACVAAAAPSSSWGGGYGNGGHGGNGGKCVTQDQATKIVHDYAFFLAHADPNQIQQANATAQRILAPDFTEQSDSINGFRGLKPGDLTFPSKAGYIDMVLVQPPIFGITDLQLVPFNCNQILWYWKFDNPGNFNAPQPPQAVQGMNIFDINDKGLIEFVAVEFSVFYYVDLGFNVSGFNGPISGVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT09</accession>
    <name>A0A1C1CT09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptide alpha-N-acetyltransferase Nat2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08916</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT09"/>
    <dbReference type="STRING" id="86049.A0A1C1CT09"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08916"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06467"/>
    <dbReference type="eggNOG" id="KOG4526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1279" evidence="3">
        <location>
            <begin position="102"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="274" mass="30553" checksum="DC2F2EC4C7F2B258" modified="2016-11-02" version="1">MKSMRLVQRNASVRHLLAARPAAHQSRAPLQQSFRTRPMLRQTVQTTSPSRMVHTQRLTTTSPSQVLRSSRLQQPSSRRPAGRRYKSSTSSPDAEPTSLKDRLKKMSREYGWTAVGVYLALSALDFPFCFLAVRLIGTDTIGHYEHVVVEGVKNLVKWPIREAAGDVVGEAEVADDKRVLDEKSEDEVLNDHGYREAERANRGDNASLWTQLALAYAVHKSFIFIRVPLTAAILPKVVKTLRSWGYNIGKMPTRKAVTPVPGVNTKGSKVKPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT83</accession>
    <name>A0A1C1CT83_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED16</name>
        <name evidence="11" type="ORF">CLCR_07991</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT83"/>
    <dbReference type="STRING" id="86049.A0A1C1CT83"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07991"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06412"/>
    <dbReference type="eggNOG" id="ENOG502QQU3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4139168at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048338">
        <property type="entry name" value="Mediator_Med16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021665">
        <property type="entry name" value="Mediator_Med16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224">
        <property type="entry name" value="THYROID HORMONE RECEPTOR-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11635">
        <property type="entry name" value="Med16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med16 N-terminal" evidence="10">
        <location>
            <begin position="160"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT51685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="933" mass="103298" checksum="644705124DB999E4" modified="2016-11-02" version="1">MDQDAPDDFASDSFFDQNSLQQQIQQIDAGADLNDPDLNGTVPSVALPPNPAVVEQLARKWYSGCVERIAWSRHGHLASISEDGSTVYLECLRYDHGSNSWDLHERHSLTTVFEEAISLAWSATGGELAVVDIKGRVWIYHVALTAINRLNLARQGALDEGDDYSQPIGLTWLNQDRQERPRNVVTHASKGETRWEHANTRAKPLGTYWPRAALIVHRNGLTTLCFQRRDGQYLKVTKQLTPQDRVLYTHASFAPTIDGKMLIAVHSYEKVISAFFLAIDWTEVNQGLEGLPVMTIDPVSSKVSSHPSGSAAVPDTFDPGSWSLSHLKVVQTSDVEKAVQTPPTILAVLTGVNRTVSIPDAGFLVSSLIKRWAVNSVETKLHPLFDALPSTGAAAAVTKPLYILQEQPDKEEQVITTVHHIDGVQTLAITTQENRTDFLNLEDLSPMSYAASVQETSCMSQSGFTFPYTQTILDPSLSPGACVRADLAANGKTQLVVMEYHLEQRQTQQPLDPHVDAAIAALNLTFARACWSNATIDDILMCASRTIPPALIPTVISSVYRTLFRDGEFVHEKTPGSELERMFHKQVMAKVFSYHASLASTCSQLVSVASTEARTGGWTLSAQWAWIVNNVRQTTTLLFMNLRDIQNVTIVVGQDFTDMLCANLRWGLSLIRFIFNAILEVGDRESNPDMFDDKARGRLGDTHGDGSQGLVALLLNCHASRVFLIAFVRAVRTYAKITEPKSQHQLQVLQCIQQQTNGKGLSFGAIEALLEYRWSAAGDVEGNIAATAVRQLDMMATGIVHEAYQPTIKTLLSKLVNSPSGLRAKMLVDRLKLFVDHVDLEYIFLNQGILGHRRDGRSTEVIYDVLRKRPITKGTAEPHGASQPMVRKCTRCGSFSEDVVVPPKEWPRQIALSLARCVCDGNWVLEPWEQVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTX3</accession>
    <name>A0A1C1CTX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">tubA</name>
        <name evidence="17" type="ORF">CLCR_08316</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTX3"/>
    <dbReference type="STRING" id="86049.A0A1C1CTX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08316"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06195"/>
    <dbReference type="eggNOG" id="KOG1375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT51934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="448" mass="49894" checksum="E9D27761E236BFF8" modified="2016-11-02" version="1">MREIVHLQTGQCGNQIGAAFWQIISGEHGLDGSGVYNGTSDLQLERMNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVVRREAESCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICMRTLKLSNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAVTVPELTQQMFDPKNMMAASDFRNGRYLTCSAIFRGKVSMKEVEDQMRNVQNKNNSYFVEWIPNNVQTALCSIPPRGLKMSSTFVGNSTSIQELFKRVGDQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDASISEGEEEYGEEEAPLEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU06</accession>
    <name>A0A1C1CU06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF821 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU06"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08586"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06139"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="1">
        <location>
            <begin position="162"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="431" mass="50114" checksum="30EAA87938D5F1D9" modified="2016-11-02" version="1">MPSSRRGLYERTVEPVLATLNRRTSILVVSVFFTLTLVAWYRSAYGSTAPLLHSDYGAYGRKRGFDGTWDYQRDAENLMLDSQQCDHAFPGLFEEVDRPVNERMHTPITFDEIDAIPKQNGYVRAMIYNQQLYIIDKAGGIYSREIATLHALHRAILTSPEPLPNIEFAFNTDDRIPSVPLWGYARRAEDTHIWLIPDFGYWSWPETKVGSMREVQMKAALTEAYDGWTWAKKVRKILWRGATMGLPLREKFIQVTADQPWADVKALDWHNKESMANDLKSMAQHCQYKYLAHTEGNSYSGRLKYLQACRSVVVAHTMDWIQHHHPLMRASGPQQNYLAVDRSFDDLEQKIAWLEAHDQDAERIAANSVKTFREQYLTPAAEVCYWRKVIHGWARVSFEPEFFKVVNGSRVWRGLPVESYLLERRLEWNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU28</accession>
    <name>A0A1C1CU28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_11367</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU28"/>
    <dbReference type="STRING" id="86049.A0A1C1CU28"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11367"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06125"/>
    <dbReference type="eggNOG" id="KOG3991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="496" mass="55994" checksum="417785FF7D7742A2" modified="2016-11-02" version="1">MATPDVDEMEQFQQLSDHYQPSLPGPLIGSRKPLSELVTEYSQADPTYVAKTKVLSFPLITYVAHRWQALEATHSAYRRIKGDGQCGWRGAVFGYFEILLQSRDFSLVAQEEVRLRSHEQTMRAAGIDYDIITDMFDYTWELFGAIKSATERGDVNETVLLQSLNDENISNSIVYHFKMMTSAFMELNPDRYKAFLEMSVQQYRLTRIDPSNQEIDHVGLQALTDAVIAPAYIAVEVSYLDRSTGDEVTAYQFVDNAKGWPTIRLIYRPGHYDIIYKDDHRPVHHPQPLQVYLQTDVPQYIPAPEEGVFRSGNTDVLGELSFLFPNAAQTGSATSMSYPNNHAFSSGYQPQPPLVYSQRTTPQNSYFPELPQTVFHATIPQHPPPPVRTRSLPQQGYSSTTTHLTPQISPSPQSPQPPSPVTPTSVTTNRSIILPKSAEPQIRYNENCFQYSIEKNKSIPLDPATFGSAALSPAHFSNSNFQPVIWSPEEEYSKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUG7</accession>
    <name>A0A1C1CUG7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_09104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUG7"/>
    <dbReference type="STRING" id="86049.A0A1C1CUG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09104"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06010"/>
    <dbReference type="OrthoDB" id="10027823at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20359" checksum="56E159CD93622D38" modified="2016-11-02" version="1">MAADDRRSWVTYFFKRKFNLSEGQLGSIFSITGVISALSIFVASSISKRIGNVKTMVFTHLPSAICLALIPIPSSLGGALAFLIGRACTQVMDVAPRSAFLAAIVRPHERTAVMGTINVVKTCSQSLGPVITGVLGTKNHFWVAFVAAGALKATYDLGLLAVFAEKEARKNRTERVDEEEQRGASRGVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV89</accession>
    <name>A0A1C1CV89_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AP-1 complex subunit mu-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apm1</name>
        <name evidence="10" type="ORF">CLCR_10098</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV89"/>
    <dbReference type="STRING" id="86049.A0A1C1CV89"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10098"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03794"/>
    <dbReference type="eggNOG" id="KOG0937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="9">
        <location>
            <begin position="167"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT52390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="448" mass="50729" checksum="B0A571018A5341DB" modified="2016-11-02" version="1">MASAIFFLDLKGKTLLARNYRGDIPMSAVEKFPVLLSEAEEESSAVPPCFSDEGINYLYIRHNNLYLLALTKRNTNAAEILLFLHKIVEVFTEYFKELEEESIRDNFVIIYELLDEMMDFGYPQTTESKILQEYITQESHKLEVQARPPIAVTNAVSWRSEGIRYRKNEVFLDVIESLNLLVSATGNVLRSEILGAIKMKCYLSGMPELRLGLNDKVMFETTGRATRGKAVEMEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTAVKPLIWVECVVESHSGSRIEYMLKARAQFKRRSTANNVEIIIPVPDDADSPRFRTNVGSVHYAPEKSAIVWKIKQFGGSKEFLMRAELGLPSVKGDDERGGGMTGGFGGSMGGIGEGKSKRPINVKFEIPYFTTSGIQVRYLKIIEPKLQYPSLPWVRYITQSGDIAVRLPDVQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVA1</accession>
    <name>A0A1C1CVA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">B-(1-6) glucan synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10359"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03840"/>
    <dbReference type="eggNOG" id="ENOG502RF47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651136" evidence="1">
        <location>
            <begin position="19"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="360" mass="40807" checksum="68B7CA509D02F95F" modified="2016-11-02" version="1">MHASAIPIFALVTSSVWGLPTTSPTRGQGASCFPFGSATFNGSVQAPSVTRQQWWCPQSMTYGFLGFSYPMEGECYDDSFERIDADLRRQKRDFGASLIRVYLPYCYTTYIWESLIEAAVANDMGVVAQVAWPLNGDPLEYWRDIAASIIQILSNSTYSDIAPYVFHSIEFGTEPIGDQDDGDNFINELKAFRAAVKPYGIPVGISEDWDRPGILCSNYTAGEKPGLGPVGKQILPQSDFVHSHIMPYYHGHNISDSWEYIADQVQWYKNYTPVPLVISELTAGDKQTQWAWELNVLHQGSKDIGTQQYTTFWHNYDANCQFFKKNNVGWFLHAWKWEGTFNIVMPNDSYAIPDWKPQKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVB6</accession>
    <name>A0A1C1CVB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVB6"/>
    <dbReference type="STRING" id="86049.A0A1C1CVB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11407"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03843"/>
    <dbReference type="eggNOG" id="ENOG502QVN2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7772923at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005085">
        <property type="entry name" value="PRK06520.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF1">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="381" mass="42865" checksum="A868850151517563" modified="2016-11-02" version="1">MPLPTGVYRADQVGSLLRPKEILALREKIAHGEASIEDLRPLEDKYIANVVRKQLDAGLRAITDGEFRRAFFHLDFLQHLDGIEVRGQLMSTNTSKGGFQPPTLVVTGKLAHTKAIQVDDFKFLERQIREAGGAGQATTKVAIPSPTMVHFRGGRQTIDLDAYPSMDDFFDDLARVYQEEVRDLYAAGCRFLQLDDTNLAYLCDPKMRTEAEARHGSDAREIARQYASLINRAIEKRPADMTVGIHLCRGNHRSQWFAQGGYEPVAEVLFRDLNVDVYFLEYDDARSGDFSPLRHLPENKVVVLGVMTSKKGELDDKDAIIQRLNEAAKYCKKGLDQLCVSHQCGFSSTMEGNELSEEQQWGKLRLEVDIAKSVWGDDLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVC1</accession>
    <name>A0A1C1CVC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor SUI1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVC1"/>
    <dbReference type="STRING" id="86049.A0A1C1CVC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09790"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03850"/>
    <dbReference type="eggNOG" id="KOG2522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000008">
        <property type="entry name" value="eukaryotic translation initiation factor 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="575"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="666" mass="72077" checksum="BC67D7992599E0A9" modified="2016-11-02" version="1">MFKKKPQIKNLSPLRSSDRRKLADQIIAEYKVHVPTLEEIDGTAAEGQPPSTQPTPALSSIRTSLVPETCLSARFTTHAGANLTLVSGTVYVGAHPGQEERILWIQYGKESRLYPTVYTLWHNPGLTPLLHTPDFVVEKLRTGADLMTPGLVGGPPWPEGAKVGSVVAVAGLERPSVPVWVGTCKIDVSSLGRVQGAKGAAVEGIHWEGDEIWGWSQFGSGGRAGPESIEGWDTLSADIKAGVEGLDLEDNDEDDDDDDDGPNGGVALEAGAAAGRLTSDEANAKANGPADAPEAGAEPEREPTTAEVDDAFMQAFLYALYDARKNAEPPHHGLDYPIQPSFLISNMIQPHLRFQNQQYTIKKTSWKNTKKFIKHLEKQVLVKSKDRNGGETVILDMDLDDERVRTFTPYRLPKPKVQTSTGGAAEGNPTPASGGTDTSLGQKLTLQTVYRASSKLVPDLIPSKTTYYTSAQISAFVKKYIENNPSLTEASSSSPRFIKLDPFIANNILGSSNPSAADTRVLAAGEISRDALVKRILEDSHLAIPHWLLHRPDQTYDPDSPDPSLKPKSGPAPQVGVVLEKRSGTKVVTKISGLEVFGINPQVLAPELQKKCAGSASVGQHVGGKPGMMEILVQGDQRDVVEKELSRRGVDKRWITVDDKTKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVG9</accession>
    <name>A0A1C1CVG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVG9"/>
    <dbReference type="STRING" id="86049.A0A1C1CVG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10680"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03864"/>
    <dbReference type="eggNOG" id="ENOG502SPZ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2378324at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="234" mass="26380" checksum="144FEE685E45FC5A" modified="2016-11-02" version="1">MASTSLPTKVLAGVTVPDTPLISKALDYTRQYSTPDTYNHIVRSFLLGFIIADKVLPDRDREAHALAAIMHDLGFPLGHPPNSDIITTDKRFEVDGANAARRFLQREAPAEEWDKHRLQLVWDSIALHTIGSIVFEKEAEVQACSYGIWADFQGPDRVPGGLLTWDEYNAVVKEYPRLDLMKGLKANMCHLCELKPQTTYDNTVGEWGDRYVEGYSRKGKLTQDLLETCNLDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVP2</accession>
    <name>A0A1C1CVP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_10177</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVP2"/>
    <dbReference type="STRING" id="86049.A0A1C1CVP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10177"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03945"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651074" evidence="6">
        <location>
            <begin position="21"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="118"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="398" mass="44315" checksum="522D2DD854C8DDE3" modified="2016-11-02" version="1">MAQPLKVIVVGAGLSGLALAHGLKKNGIDYVVVEKESSPRDRNWGVTIAWSHPLLAKLLPEELYKRLPECQPDPGLDTKAAGFESVIIRDGQTGATIVEPPFPGVRRLNIQKTRTIWAEGLNVKFGKTVTDIELTSDGVEAHFHDGTSESGSVLIGSDGGGSWVRRWMLGDLASPRVLPYTFLNFPFRYTPEQAIKMDKMMHPIVDVAPHPKSMYVGIFLLDKPDLQKPETWVFYILATWAKQDSDYVEGKNMVDELRRRMDDWADPYKSAVEWIPADTRAKAVPLRIWGPPETGWDNRDGRITLSGDAAHSMTFHRGQGANNAICDSEKFVSAMIKVQSGEKSLLEAVNEYDVDVISRGRTEVEVSRVQTDAFHDHAKFLDSPVVKHGIKPMSDVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW52</accession>
    <name>A0A1C1CW52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW52"/>
    <dbReference type="STRING" id="86049.A0A1C1CW52"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10312"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04112"/>
    <dbReference type="eggNOG" id="ENOG502QW00">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="187894at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048244">
        <property type="term" value="F:phytanoyl-CoA dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047128">
        <property type="entry name" value="PhyH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308">
        <property type="entry name" value="PHYTANOYL-COA ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308:SF8">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G09620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45616" checksum="824C4F0B95222A43" modified="2016-11-02" version="1">MASNGDTLSNDVDKSLHPRVPKRLYSLSQPPSIAAFDKLCSQSTAAESYPKASTIISNIPVYDLRQDKSATEDIIDELQDEWHYILHSGPGVFVLRGFMPDTSLINEVNAVFDDIISLEVAASTTKGDHFASAGTNARIWNSFQKHAERHPTSFVRYYSNPYLAAVCEAWLGPAYQITAQVNIVRPGGKPQVSHRDYHLGFQTAALCARYPRATQTATQFLTLQGAVAHSDMPLASGPTRFLPFSQRFEEGFMAYRLPEFQAYFDRKWVSCELSMGDAVFFNPALFHAAGENCTDNVHRSANLLQISSPFGKTMETIDTLTIIERCWDETRRLYEQEGRGTRMSKEISAILNAMGNGYPFPTNLDRRPPAPGGMAPESEVDVLRRGLSAGWDTQEVVAAITAMRRQSASTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW86</accession>
    <name>A0A1C1CW86_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional cytochrome P450/NADPH--P450 reductase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Cytochrome P450</fullName>
                <ecNumber evidence="16">1.14.14.1</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NADPH--cytochrome P450 reductase</fullName>
                <ecNumber evidence="16">1.6.2.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CLCR_09500</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <cofactor evidence="16">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="16"/>
    <dbReference type="EC" id="1.6.2.4" evidence="16"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW86"/>
    <dbReference type="STRING" id="86049.A0A1C1CW86"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09500"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04152"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070330">
        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06206">
        <property type="entry name" value="bifunctional_CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11068">
        <property type="entry name" value="CYP120A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023206">
        <property type="entry name" value="Bifunctional_P450_P450_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF127">
        <property type="entry name" value="BIFUNCTIONAL CYTOCHROME P450_NADPH--P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000209">
        <property type="entry name" value="Bifunctional_P450_P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 16" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 16" id="KW-0288">FMN</keyword>
    <keyword evidence="4 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 16" id="KW-0521">NADP</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="18">
        <location>
            <begin position="498"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="670"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000209-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCT52807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1048" mass="115896" checksum="C2A3A9536553CB66" modified="2016-11-02" version="1">MSTPIPAPPGIPLIGNVLDVNPNNANESLTHLANKYGPIFKINVFGQERYIVSSVELLNEVCDEKRFCKVVAGALDQVRNGAGNGLFTAHHGEHDWEVAHRILVPAFGPIGIHDMYDEMYDIATQLIAKWARTGPEQKIAVADDFTRLTLDSIALCVMDKRFNSFYSEKMHPFVDAMVGFLLESGRRGTRTRIGALFNRTAEREYFENIATMRNVAQEMVDHRRANPTEKKDLLNAMLFGKDPKTGEKMSDQSIINNIITFLIAGHETTSGLLSFTFYQLSKNPEAMRKAQQEVDTVVGKGPVTVQHMSKLPYIEAVMRETLRLNPTAPGFSVTALPTVPGPVVLAGKYTIPHGVPVVVLLSKAGRDPLVFGADADEFKPERMYGENFTRLPPNAWKPFGNGARGCIGRPFAWQEAILAIALILQNFNVRMDDPSYQLQIRQTLTVKPDNFFIRATLREGINPVTLERKMYAGLEVEDAHKKDRSALASNVGDAGKPMLILYGSNSGTCEGLAQNLANTAGNRGFKATVRSLDAAVDQIPGNQPVIIITASYEGNAPDNAARFVDWIKTVDAGKVKETQYAVFGCGHHDWVSTFQRIPKLIDREFDARGAKAIADRGQSDVAEGKVFDDFDSWVDEKLWPALSVDPEGNEVAEGLDMVISTSARASHLRHNVQEALVLKNELLTEPDIPEKRQTEFNLPTSMTYEAGDYLALLPLNSVQTISRILRRFGLPWDAFMTLAKGAHTTIPTETAIAVSAVLGAYVELNNPATRKNIATLSRYTKDESIEKELLPNVEGLSILDILEKYPRIELPFAVYLSMLTPMRIRQYSISSSPLDDPTKASITYSVVGSDPKHLGVATNYLKGLQPGSRVQLTIKKSHKSFHLPLNTKTPIIMVCAGTGLAPFLGFVQERAARLGASGDRDAFGEALLFVGCRYHDKDRLHGEKLDQWARDGVVKVFYAFSREPERSEGCKYVQDRLWKERGPVSELFDNGARAYICGSGALGKGVADVAARLAVENSKKKGKDITHEQGLKWWDGLRGERYAVDVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWE8</accession>
    <name>A0A1C1CWE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">High-affinity ammonium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_09928</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWE8"/>
    <dbReference type="STRING" id="86049.A0A1C1CWE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09928"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04212"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="25"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="292"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT52872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="504" mass="54204" checksum="5B5795BA1BCFD31F" modified="2016-11-02" version="1">MATDEVFTFGPVPAAPQKNGADVGWMMVSSALVLLMIAGLCLHFSGISRPQTTLTLVRLPLITTAVVGCIWYTWGYSLAFSPATFSNDTFAGISWYGGDMKANAYLDITARPVGIQGPDSSSMTGPKIPEMVYVFYQGMFACFTASLVAGGAAGKMRVGRFLLFITLWVTLVYCPVARWTWHPQGWSKLRGAMDFAGGTAVHVCSGSSVAAFAVFAQIEARNWTASVTFGNRMVKLDVKTWRIWRWISSSPLPRGTEVELTATPPETVSGVHGIVPTPQQQPSTPSPESDLEIQQAQLPYSINHMVLGTALLWIGWFGFNGGSALGANLRAVSACLATQTAACAGGTVGLLLQWGLSRLDRMAVDPAQLFHTPSMQEFCDGVIAGLVAITPAAGYVPVKYASIFGVVGAVVCKILRMIFNTFLLREDRLSVFAVHAGGGATGMLLTAFFAKYALIESSLERDEKLTTVVLAMQPLASTGTVDLWTERWVLAFGKDIHCAQTIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWK8</accession>
    <name>A0A1C1CWK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_10854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM234 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10854"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04161"/>
    <dbReference type="eggNOG" id="KOG4831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43458at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT52816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="16876" checksum="24D17138F5B2DF44" modified="2016-11-02" version="1">MSASDTDPGSSAPSTPSPFNYILSFLLVGVCWGFTTPFIRKAAVNYTAPSHQSMTDPNRSWISRQIAKAFFTVLGLLRSPGYAIPLVMNLTGSIWFFLLVGQAELSLTVPITNSLAFLFTVLGEWYAEGKLISRDTWLGMVLVCGGIGLCVWSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWR8</accession>
    <name>A0A1C1CWR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial matrix protein family glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWR8"/>
    <dbReference type="STRING" id="86049.A0A1C1CWR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10442"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04217"/>
    <dbReference type="eggNOG" id="KOG2536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="310" mass="34649" checksum="D69A5B85A96AF7A5" modified="2016-11-02" version="1">MLSLRVLGRALPKALSRQPAVRSISSISKFAPRRPQWQTASKWSYPAFSTSVARREPAGQSDEALIAKLNNERQLELQSQTDDKQAIIDEFLENSPFKLHDKPGSHEIVLTRDFGNEKIKIKLSVSDISEYPAEDDFDAIDEDGALSDEDFGAGRKTANQSGARGGKVDVLPEDSIAPVDRAEGEEAEDEQPSPAYPAQLTITITKPGNKAIEIRAVAQDGTIEIENLSFFPKESLLDAQSTKDASEARSLYAGPPVDELDPELQQMLQQYLEERGIDEELASFLPEYMDYKEQKEYVKWLEDLENFVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWT2</accession>
    <name>A0A1C1CWT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulatory factor Sgt1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWT2"/>
    <dbReference type="STRING" id="86049.A0A1C1CWT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09764"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04353"/>
    <dbReference type="eggNOG" id="KOG2406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="680" mass="76468" checksum="2A288515A984DDD6" modified="2016-11-02" version="1">MPPIEEDIAWFRSTFHPIPRPTLPDDCIEYSLYIISPSQDTQGDSDVRGRLREVQKYAGDLQRQYLREYIWQRQKFMLELQKEDGEVCTGMTRTVANRLTPGIGLSFLRGQTEYGDSVEDEWVIVWLLRELTTKFHDLWVKVTDSDGEFLLIEASGTLPSWLEPDVAENRVWINHGQLKIIKPAAAARTSKRTEEKLTLEQARSIIVSEPRRLMHSISIEEEAFFRIRNYPAQIAENMHHAMITIPRKVAYLLHQKPAYIAPAVEAFYLRDPIALKPLQSKENKDKMAFPPQDFVTVSVKFPRVAYAQVKSQDFPPPAVFADTLPSKTDIKAYVAAETGMKITCGLEMLVTDSHHQDRPEVREMKLILDDLASGDEVLPSDNEIETWEKREDDEKWLDINFADLENELGGRKGQSDTMGKKHSFGDKAAQENLQRIVKQFEDFLNDDKAGMEGAGLGDSDLDDDDDDLDDDDLDEDDEGEDKEASFGEDEFTKMMQEMMGIPPEVMQEIMKGKLGPGAQDPAVRSGLRPLPDETETDVVKADEGEEDDEDIQTFMKQMEAELRGHAALNLSSAETGAGKQKAIAKSNSHRGDRVADDDEEYELSSDDDIDNEIDIDLARNLLESLKAQAGKAGPGGNLMGMMGLKMPRDEADSDEEDDGQPGPSGVRTIPEGLPKVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWT8</accession>
    <name>A0A1C1CWT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10719"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04219"/>
    <dbReference type="OrthoDB" id="4157269at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="150" mass="15303" checksum="F73EDF879A74C990" modified="2016-11-02" version="1">MASSASSAASSVFSSGTSLARESPAHAAATAYAATESARSFSYASVFFIAVTGIVTAVAIVAASVYFSGYADDVAAWWAKRYYKAKAIAEVKVLENVGAEKVQGAVKDSLKKNPIMGEDELEQVSGGLGKEAVQQGIGGVSDKLGGLGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX43</accession>
    <name>A0A1C1CX43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_09725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX43"/>
    <dbReference type="STRING" id="86049.A0A1C1CX43"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09725"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00116"/>
    <dbReference type="eggNOG" id="ENOG502SM8G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF9">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="240"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="560"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="698" mass="76611" checksum="CF829D8B800EF9EA" modified="2016-11-02" version="1">MDASHRIPSPVNGDAGVEETRPTKRPRLNPSIEVGFMRDGSGRDSASFVGSASGIHFIRSVYGALNARASARNLPGETPESNIVPGEDDRLNSGPDSGPSKPLWQSHEVEWHAASPTTSVTFDDLLDWTSSYFDVWHPPFPFLHAPSMLERFETLAHNGIAAVGPFDVTIIKAVVSIALADRRQTNTVSRPVPKALVFTSFEEALNSVHAVMSKPATIQALQAAVCVQLFLVSMLRLNAASRLGGLIIRVLFQLGLHRCPARFASFKAEEQQLRRRLFWSIYCIDRHICQALGLPLTIRDDDVDVCYPDNEIHTLQRSNGSTSRPDTPSPDASSQQDGRLRLLTLIAKHAEIRGLIMELRNKRVEYRAEGWDKAVLINAKLTQWWNQVEDSIEQAELHDTPLSDLHQTVLKVLKHESVISLNRPLLAASKTSANYAAALQSCISASKSIIKALNMVAHTVMPAYNPPDRSRNTHFPMFWPSFTWSIWMSAFIILYAALESEIDYNVAVRQPAESGRSPLTWGNRNTDRALHVLTTLAARGNVWPTACAVAIRDLRSTLDETRKEQSMGQTSAHQSGQRLALPASDRDDSVPAMHPSTAQPVSSASMSPPDVATKGHSQQASSIHDVPASCETPSLEANGAQTALYAEAMPGNSWLGLGIGMDLGTELPMFPNDGLDPLQGFDIPFWVGQDNYATWMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXB9</accession>
    <name>A0A1C1CXB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11412"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="226" mass="24835" checksum="3D42AE2A4BD2F974" modified="2016-11-02" version="1">MIFTLKMKTLELVGPAGAGKKNPCWATALSSISPLTSHYARFILSLLLGLAYAPRVHAYTQIKLNGVSLESLEALETKGKARYDQILPTLRDRQKTTSFYTPSFEVTIVDPQPDSKPTDSIALVLSPDTINDDFSVPVGKLTNRPVVDSIQWSDEAFLDFKQTALKKLESLGIKMDQFGFTPVSGLTGENVVVTPEKWLGTILDGEIPTLVTCLDRTLRSESKDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0J1</accession>
    <name>A0A1C1D0J1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_00274</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0J1"/>
    <dbReference type="STRING" id="86049.A0A1C1D0J1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00274"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10193"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="85"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT54265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="363" mass="41477" checksum="5CD2F865425642BB" modified="2016-11-02" version="1">MHSDMRSLRVWILPPILTAVRPRNRRPPLRGTRTRLHLASSPRGYATGAENALHPSQSVEEETLPHYDPDEFYPVHISEVFNGKYQVVGKLGYGANSTVWLGRDITTDRMSNYVTLKICTKTPTESIDREILAYRHLGSLRSSHPGLPHVRGLIDSFEVVRSDGSHHHCFVHQPLHLTMWDMQRFGGTSTTFPQGMVKSALRYLLQALDFLHTEANITHCDIKLSNIMLTIEDEGVLTDFEDAERQHPCPRKICLCDFGEARIGGSYSYEEIQPEVYKAPEIIMQTDWSHRADIWNVACVAWDLMEKKHLFDARDDEGFHNNRYHVAEMVAYMGIPPMEFQRRSPNTALVFDEEGELTNSTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D119</accession>
    <name>A0A1C1D119_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SNF2 family helicase/ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_00759</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D119"/>
    <dbReference type="STRING" id="86049.A0A1C1D119"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00759"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01700"/>
    <dbReference type="eggNOG" id="KOG0298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18070">
        <property type="entry name" value="DEXQc_SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1081"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1141"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1328"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1143"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1353"/>
            <end position="1369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT54437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1460" mass="163989" checksum="59AA35982A957662" modified="2016-11-02" version="1">MSLPTDTTHDLAIDSRAADSEMDEVEERAPKRRRISNYADSTPPAPFSDYIVLAHARYTDIATCPWLPTGSDGTFLAVSVRDVTRCERGYEVGLAGGKWAREKRFLTEDLPPDDMRILEDARKLDSVARYKHPAALPLACTHAFLRQNGQNVTLEISILWQDTVALRDKVDPALLEILAKYMPPTRPISPDFVQWEPRQFYDNVHVPEKSEANSAELKIPALESTLFPFQRRAVRWLLAREGVAEQADGSFQARQGTPSDQSLHGFEKHITCSGETCFVSHALGVASTDLAAVRQHFVAPKGGVLADEMGLGKTLEVIALMCLHPRPTQLVKPSGLLPSSATLIITPPSILEQWKSEIQEHAPSLRVYHYQGLSSFKKSGESYLESLVDQDVVLTTYNVIAKEVHYVSEKPDRNLRNKKTREKPPKSPLTQISWWRVCLDEAQMVESGVSAAATVARLIPRDHAWAVTGTPLRKGHRDLFGLLLFLRYAPWCRSPRLWDRLVTYHRPLLRDMLGEVVMRHSKDFVREDLRLPPQNRHTITIPFTPIEEQHYTQLFQDLCEDLDLDRTGAPLTDEWDPESPAVVEKMRTWLTRLRQTCLHPEVGGRNRRALGRKTDGPLRTVEEVLDVMIDQHEGQLRTAQRARLMAKLRRGQLKENAKAGKEALQIFQEAYNESLVVVRECHTQYDQARLSLGVNKEQGAVSKEKEVDEEANLRLSTLNARVRSALETHHIACFFMANAFFQLKSVHPPESDEFQQIEEKETAAYEKAKSIRGELLKGVTRHVNKLVTTVRANLAGGCTQIPIMEAPTGLGGIESKKIFEKLHLFCEAMNVQAEQFHALQKKMADFLGQALIDEDEGVELQGDEYESSTKHQDEMYAYMEALRALLADRNEAISGQENMLIKQEMKQFLSVAKEGEGPAPDVMLRLLAEREQKRVKASEFGSLRGIVAQLRQMVSSLQWQEGNNQNRASHELAILERLLKHMQQLGAAQVKALTALEQDVNHFRDTMNSRLEYYRALQKLSDQVAPYREDSIGQLLDDRLYQSFLADEMRLQQKIDSISAKLRYLVHMKADDSKSTAPRVCLICTDQFEVGAMTSCGHSFCKECVMLWYSQHHNCPVCKTRIPPNGFYDITYKPAEIAVQAESPSTSTTSSPGARSERQHNQSIYSDISTTMLNQIKNVDIRGPSYGSKIDFLCRHLMWLREHDPGSKSIIFSQYREFIDVIALAFQAVKISCTRIDVKNGTEKFKSDPSVECFLLHAKAHSTGLNLVIANHVFLCEPLINTAIELQAIARVHRIGQHRSTNVWMYLVADTVEESIYDISVTRRLAHMRSNSSSGGGGEDDNDTKGKGKRKSTTALASAGQSGTNTPRSDNALRENAIDAANSMELQAADLSRLLTAGKSGGEMVDKEDLWGCLFGRINRRDGASGLSALAESQPANTEVGRFLRAEAATGRATQSRELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1K5</accession>
    <name>A0A1C1D1K5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Efflux pump antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_11442</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1K5"/>
    <dbReference type="STRING" id="86049.A0A1C1D1K5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11442"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04849"/>
    <dbReference type="OrthoDB" id="2351791at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF59">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT54753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="332" mass="35792" checksum="6A9B74D7A0485504" modified="2016-11-02" version="1">MVLAVIVLADIFLLGERAKYVGVMNAVWAVGSVCGPVLGGALAQRWIFWINIPLVVLSITSIAAFLPRRAAEIPLWTKLGHIDYVGIVMFLTFGVLFFLPLVFAGIIRPWSSWEVLVPLLVGSAGMVLFRGYEKKVAKEPMLRLAVFANRTANVGQFGIFVHGVLLWSLSFRKLFTVAPAAVVTGLYISSTGQYRWAVWAGWFLTTLGYALLCLLKPGTTVPSWIVLDLVAGLGVGMLVPAVSITVQAATQGTNVFHSISMYALVRASGQACGVAIGTAIFQTQCKSVLAGMSGINLTAEALIREIHQSSGTPDQLDELQEAVVRSVRIVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D217</accession>
    <name>A0A1C1D217_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GRAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_02722</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D217"/>
    <dbReference type="STRING" id="86049.A0A1C1D217"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02722"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04796"/>
    <dbReference type="eggNOG" id="KOG1032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="883"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="567"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="772"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1053"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1202"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1231"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="802"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1067"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1078"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1203"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1260" mass="135638" checksum="7A4757F47F1E51C4" modified="2016-11-02" version="1">MPEPSPQLKGLKKVLTSRRRSSEPAIDETIRDLRTESLDSITIEKSPTRQSARSISQDGSNKSGSSGVRKLLPGHSKRQRRRQREAELKAAVEDLARGRTGTGLSAMTSPQPALSRRASSHGGEADAGLLTDDSEIETPPLVTRDSHTGFASMSSPLISTTTTRSDGDSLQSPVKGLSIDKIPTLIEPAAEVSGSPSPKSTPVPESGPASPFAAGLVDRADTLQPESRRNSVSTRGKSPVRRFRDVFGKQGKSPKVSPERRETMPAMGATGNESSMVRSNTEVQANNEPKPIDAPPPVPPVPAIPQTSSMPNLETSLRPLTPPARVIDTPVTTVTPPTPTDTRFEGTTGSPKPEKPASRTGPDGSNIVVSSSGNMISHRRIRSTSSTTHQPSKLSTSVTAPLTPTDDKRTPSGGIFSSWVSAAQNAATTITNLTGQNRNRSGTNASDPAVKPKTVEEPIKEEEEVSEPETLRRQLAVETLGSGDLNFEHLGLTIDDAGASAPKSELSELRKDSTLEKDVAAAKVEDTLAKRAVSAAYERMSATSTPVAEIPDPLGSSMRHAQNIAAANTGERTPPNGSVFESEVGSIKRTGSVRSKMKRRSRGSSTATGQSAIGAMIGASTATLANPATGPRLTGFTMAPKQRNRNFHQQFRSVPEDDYLIEDYSCALQKEILLAGRIYISEGHICFFSNILGWVTTVVISFEEVVSIERESTAVVFPNAIAIQTLHARHTFRSLLYREQTYELLIGIWRVSHPASFQKSINGKQLAAEEASVAPVVEDGASGQPSEGSTTEESGSEDDDSAPSLLDSSASAAGSDVADAKVVSRKPSGMNASAVAQTASILAGTAGDVPQPLAAQAGLPEAAKDFPGPAAHVPTECSDGGTHYDKIIKDEVIPAPLGKIYSLLYGPESGFFVRKFLADECKCTEVVFEDDKKGLNNDIKSRQYSYIKPLGGSIGPKQTKCITTENLDAFDLEKSVSVTCSTQTPDVPSGSAFSTKTRYCLSWAPGNQTRLQMNCTVEWTAKSWLKGPIEKGAADGQQQYGDQLMKVLKSAVSGRPRGTTNASKGSKLIKKKRKGEKKAKEEIQEEEKAQAPNWGVFEPLRGPLTPVTDMLRPVLKMEAVVAILCVMVVLLWIRGPSTSTQLGPHSSHSSRMAAYDSMWVREENEFWDWLESRASVDTVVLRQQSGANQRRNRNEASVLAKQTLKQQRQGRPKSASSLDVEDQIKAEKISQRELEDAIRITKERLEVLENVVDKKKRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D262</accession>
    <name>A0A1C1D262_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL/TRIO domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D262"/>
    <dbReference type="STRING" id="86049.A0A1C1D262"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02830"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04869"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="30289at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF3">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="124"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="583" mass="64480" checksum="78B7CE0DC6C075C8" modified="2016-11-02" version="1">MSALYRTLTGQSQKSHHSDHTVGSQAHPTLTRTTTTDPLTGTLNHLTAPQEQKLEEFKEKLQQGGWWSPDGVNGKPSHDDGTLLRYLRARKFDVQGAIGQFTDTEQWLKEQMVDELYDNFDVEIYERSRQVYPQWTGHRDRRGIPIYVYVIKQLDSKHVNKYQKESQTYKDSLPNHKKLQTPAKLLPLFALYQNLLNFVLPFVSTLERPNPEVPVTNSTNIVDISGVGLTQFWNLKNHMQDASVLATAHYPETLDRIFIIGAPSFFPTVWGWIKRWFDPVTVSKIFILGKNEVKPTLSKFMDPKDFPKRYGGELGWDWGDQPHLDEETRAALERDGNKGWVRGPCLWLDGKRVAVGSESGKPRRPATDIEKMKPVVYAADYTETPVHPDKKLSIVSKTRVSNGTAPAHHAAEEHAAEAKDGATAASILATKSNSEPPAQVGSNPEQPAQVIPQPQSTEPQPEPSTGSTSEAQASQLISSATYAHPPSQPQPGPIPEHTVALTSAIENKLADESVSIIPPTANGHANGHATAPGEGHAEVVVASDLSKGLAIETEKLNMTDDPHQKEGGAQRPGMERFVTAQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D298</accession>
    <name>A0A1C1D298_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_02924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D298"/>
    <dbReference type="STRING" id="86049.A0A1C1D298"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02924"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04998"/>
    <dbReference type="eggNOG" id="ENOG502S6QC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5401558at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="451" mass="48895" checksum="AB7CC77A1394647B" modified="2016-11-02" version="1">MAQMADAREPPRPQYPPPDDPAHGGYYSQQSPQGRPAAARDDRSPYPPPDPARQGQYPDPRAAHPYPPPGWPAQHSAYPPHYPDPAHPGYAYPPRPDLGQPPQPMQPDAYRLPPVYPHPHPGYYAPPYPQVPAAAPRQRTAIACKYCRKRKIRCSGYDSSPDGRCQNCVRFNQQCLFHPVSSQAAFVPANAVYGPNAARAPLAGQPDGRLGQNGQHYPRDGEAPPMLYGAHGQPLGPAGPHGQPQYNYPPAPPHGYSPAPYPYAPYPPAGQPYDAPGQGPPAHHDERVSLKRPPPDDDPHNENSHASQSPHPNSRPRNSTYESRQNSSGSYNEYQDPNSGAPTSPATSTMSYQSFPPQPRYANGTQSQKGNNSPPSGLTPQSAQSFNSPHHGPNHDDGRTPPPNQPGSAGSSANGRSGMKVHEMLGDPTRVPPEQRGRNDNDMLNKLDGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2F5</accession>
    <name>A0A1C1D2F5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dynein light intermediate chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_02845</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2F5"/>
    <dbReference type="STRING" id="86049.A0A1C1D2F5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02845"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05059"/>
    <dbReference type="eggNOG" id="KOG3905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="437"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="511"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT54967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="613" mass="67410" checksum="38AB3ABE37E390C1" modified="2016-11-02" version="1">MLTASQPSPAFPRPSPSTTPVPSLRRPGSKDGDKQAIWVPMLNRASKGKDLSEKQLIVLGGTPDQQREFLDHLNPPNLRPRYANNDRRRQPRTAPISNRYALGYTYHDVLDADQEDVLARLNVYMLAHPSASFAPLLKPLLTAMTVKHTLITILLDWSDPLKWARQLRQWIRLLRAVILTLDEQTKIEMEEVITAWKEKRVGPDAPSAQLGGGGKDTAEQKSVVPPGPGEWDEGLGIPLSVVCIQAEKIQNLERDYGWGEDQFDFLMQWLRCVLLKHGSSLVYTATFDSNNVRTLIHSSLSIHSLLKREVAKHNIVDRDKILVPPNWDSWGKIRILKDGFDPEAVGNAWSVEIQSPPDEKFDLLFRPTVGSEQDRPTENGEDAESAVHLFESTLRHPTSAPQSFQPRSQDETVSVPTVQEFLQAQYEVLEKLKAEDEKAERKSRKGAPAPTGSGVAGSVDGGSEDVGPKGVSNPRMAEHIGPYQINVNGIDFDPEEATRRLRERESERQNAKNLPSTSGPAGTSTPMRRMGSDHGGGGSEGTHTPTANAAGKQSNEAMSQFFANLINKKDKRAAGGANSSASASPTRAPHGTSGSLVRGNSSRDIGGERRRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2S2</accession>
    <name>A0A1C1D2S2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_02910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2S2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02910"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05165"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT55072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="481" mass="52383" checksum="1D1617974FFADDD2" modified="2016-11-02" version="1">MAMADETQAAMPIDPRQSDIEQGGRSPLSRVKSLYAHPWTQIILISLICFCCPGMYNALGGLGGSGQVDPTVAANATVALLSATAGTALFVVGPLFSYTGPRICFLLGGWTYALYSGSLLNFNHHDNGAFVIASGAILGVGASMLWVVQGAIMTTYVAESQKGRAIAVFWIIFNLGGGVGSLASFGLNFHSKSGTVSDSTYIALMVIMLVGWGLGLFICSPKRIHLAQLHAAVESEKHSWQATIDIAVKTMASWRVFCMLPLFFCANVFYSYQQNQVNGMTFNIRTRSLNGSLYWIAQMLGGLLIGVILDLPFLTRPMRARVGWVVLFVTGMSIWGGGYAFQKWQDRRLAAGLKQDIDYTQGSLSTGPIFLYIFYGAYDALWQGFCYWLIGTESNSTSRAAILVGAYKTFQATGGAMAWRINALHKSPMTQLGMNWGLSIGALVIVVPTVWTVTTMTIEKPIRDQELEMKIREVESHTGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2V9</accession>
    <name>A0A1C1D2V9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutathione synthetase</fullName>
            <shortName evidence="9">GSH-S</shortName>
            <ecNumber evidence="9">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">gsa1</name>
        <name evidence="14" type="ORF">CLCR_02869</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9 11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="9"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2V9"/>
    <dbReference type="STRING" id="86049.A0A1C1D2V9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02869"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05071"/>
    <dbReference type="eggNOG" id="KOG0021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="13">
        <location>
            <begin position="243"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="161"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="253"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="319"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="461"/>
            <end position="464"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="531"/>
            <end position="532"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT54978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="547" mass="60154" checksum="2B79D6F5C3C9EDBB" modified="2016-11-02" version="1">MAHHAGAEIYTDYPPPLTPEQEGYLVQTVKDWVVEHALTVRPSTAIVPEETNPVTVLATSAPVTLFPSPFPQACFEQARSLQQIYNELYASIASDEQWLEDIMKELIEVDDFLANLWKIHLSVKEEGYVQDLSLGMFRSDYMLHTAEDAPVSLRQVEFNTISSSFGGLACKVAEMHTHLATFPSAKHPLAYPPHPLFANSTDKSPINTIGHPPPNEAVSTLVAGLAAAHTAYGPSRSDPPLPTCILFLVQDTERNVFDQLALSTHLYNHHHIPSFRLPTSKILAYTSIPSKDTNPARPLIYTPPSSPSTPYEVTVVYFRALYAPTEYNTPTSWAARHHLERSAAIKCPSILLHLSGSKKIQQVLTSRPPDADHMKAFLPNHPETALENLRSTFAPQYSLSASQYSASSEPEGIRLALDETTAANHVLKPQREGGGNNIYRTKIPPFLNSIPRDQWKQYILMELIHPPAVAKNTVLRSDGQVVSGNVISELGIFGTCLWKNTPGSTVPEILHNTEGGYLLRTKGKDSDEGGVAAGFSSLDSLILFAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D317</accession>
    <name>A0A1C1D317_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TBC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000001">
        <property type="protein sequence ID" value="OCT55134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D317"/>
    <dbReference type="STRING" id="86049.A0A1C1D317"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00007"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00019"/>
    <dbReference type="eggNOG" id="KOG1091">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000038">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000031">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="35"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT55134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="688" mass="77476" checksum="08BCDEEE5F581412" modified="2016-11-02" version="1">MRTFTDIQRRWATLFSSSIGVDLRQALRSGEGFDPCEDGLRSVCWKAFLLYGPLSQGSWPKKLAESRSAYVSLRDHFLRYIEHPAELHSSGDPLADDDENSPWSTLRQDEMSREEIFKDVSRCMQDNFFFREPATQKQLLDILFIYAKLNPDIGYRQGMHELLAPILWVVHQDAVDVIGVPAVDRKAEGTDFMIEVLNERFVEHDAFNLFCAVMQTAKAFYELGENRDSSPIVARSMRIHDEILSAVDPELAVHLTVVGILPQIYSIRWIRLLFGREFEFKDVLKVWDVLFAEHLRSDIVDFTCVAMLLRNRWDLIEADYTTGITALTHYSLPDPTGDPRSLVRDAVFLDTNRDSEAGALLIQRYSGRRPKGSEALPNRSTPAATRAAIAPRHRPSPSASPGRFSSQQRQLEGLFREVTGNLQKRTEGWDVSKAVRSAVGEVRRNVNNYQSAHSRQPSSDGPQLVVPERRRLEQKAQEDATRDSQQKLQRLQERNIVLAKMLDDALQSLRAIKLANPTAAGDAQDNMNICLAKIQFVSVYLSDSEIPIPNEETAQAPQPPGENPDSSEKQSAAPVQTKPGTKDEKHSETGIQTQEAEQRGRETHVTSQRPSLMESSFSFMLGENRHRSSFVSSVSDLPENSRESESRSRPRKKVAEIIPHPERKGSDSDKEGVSLNKIQGEQGSKGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D3F7</accession>
    <name>A0A1C1D3F7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D3F7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03182"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT55075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="110" mass="12164" checksum="84C80661CD149F1B" modified="2016-11-02" version="1">MREPKCRMLDGHEPSKPDVRQDLAGFHIRNWVGDGNIGNELRPVLFLSSDAHGRGVELKCPEKVPLLALEGWWIGRGGAFIHAGELPQKFPIIDACMVQAKQDLSLPKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6G0</accession>
    <name>A0A1C1C6G0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6G0"/>
    <dbReference type="STRING" id="86049.A0A1C1C6G0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00594"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00996"/>
    <dbReference type="eggNOG" id="ENOG502QS15">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5312133at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055:SF1">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="633" mass="71233" checksum="0DB9F1FDBA27D465" modified="2016-11-02" version="1">MAPRHFTRYIIIAAVFLIGILIFTSTSDRSPAGVIDALQYPDGIRDLVPKINVPNSLRWSFQSSAHKPPEQKNSTHEGSSWYSDWKWLNPFSSSVTLDEDRVVLPPLADRPPVYTFYDASAKKDEETKKIDQEFLLTWRQTWWAHGFRPVILTDAEAMSHPLYQTLHSKGMPATLEQDFREWLAWAHMGTGLFASWHCLPMAAYDDDLLSHLRRGQYPQLTKYQGLGSGLFAGEKSQLEDAIKATLDDVKLSSYKAITDAIDSSRFKVEQPTSIACYDSKTVPSKYPVLAELMKKDPNKGRRSLLELMRAHLHVTWQNTFSTGIVVLQPLAAHTFTLVKPSLDLARLLAECPNSLLQSSCPPNRPKCSPCTGSKLGVKTAPSFSNTSSLFTIAVVPHPYTMITLTNQTDDISVAHIRRNTDRDPWITAVTRDLLGDARGGPSRVVSLKDAVASEYGRSRSLWFTTEHFPASFNPPPPPPKSPTNDRPVEEKIAPFPEDWLEHLDWHFGFPVPRTTVSHGESLPPVPGPERWAKVPAGLPVERKKAHEPDPPTEEQAAIEVELLRKARETINSQDEAVLKIRNVAEAWNLADTEAWKFVKSFRARQVVERLKFEEEESVFETGGVRGNSRWWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7J8</accession>
    <name>A0A1C1C7J8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Uchl3</name>
        <name evidence="10" type="ORF">CLCR_06207</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7J8"/>
    <dbReference type="STRING" id="86049.A0A1C1C7J8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06207"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07139"/>
    <dbReference type="eggNOG" id="KOG1415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000008">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="9"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT44457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="246" mass="26773" checksum="88EC359B82473BCF" modified="2016-11-02" version="1">MAEAAKRKMFVPLENNPEVMTNLSRELGLSSSLQFHEIYSLDEPSLLEFLPRPAIALLLVFPVTSTYEKFRAEEDSSAEAYSASGDQEPVIWFKQTIGNACGLIGLLHAISNGAARSNIIEASDLDKLLKQALPLKPMERAELLYNSPTLEAAHAGAASKGDTEAPEADAAIDLHFVAFVKDKDGYLWEMDGSRKGPLKRGFLGPEDDVLSEKGQELGVKSFLKREEAAGGGELRFSVVMLGPSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7M0</accession>
    <name>A0A1C1C7M0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7M0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06497"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="74" mass="7873" checksum="B1CA4B99A6CCF49E" modified="2016-11-02" version="1">MSHFTIGAFVATTATALAPFLAVYYLPRQQTTLQTPAAALATLPKPRPLAALRETREQAAVGTQANSATEFNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C874</accession>
    <name>A0A1C1C874_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C874"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05657"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07320"/>
    <dbReference type="eggNOG" id="ENOG502T2J9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="622" mass="68606" checksum="287FAB9590604E77" modified="2016-11-02" version="1">MADTLDLLGVIGTCLGVVIGLVAIVGVITPFLVLRAAHSERSQALGKVDGAGTGYIKNRWKITRQTRFRSVHAPILSLLPGEGEVRLLRTVTLGQGKRAEDVVSSSSTGWVNLAKLAEFYSSGSKKGDPLLIRHGEAWFPVHRFFILGIGLRGRYGHRPDRGESRSVRTTARLFTEEGNLDDEDAYLNSGTANKLYGTTGVAWWRQSLDSTETRFDEIYFAQHPDRPRLEHLVDPTPLSELFWLSIGCLPMGDGRRVYDLDMSNRAPVVSTRPTDREDRPRKDKDVRPRKDTVAFTRRESLLERHTEWATSMGAKERDIYYLEFPPGVRTNTSRVAVKEADRQHLALGILKLTLSAGGFLLPAGRNLSSFFRGSKFSEALKDPNNVDHLGDPLESLALTLTTLGAHGDVRGFSRQRAQLCAEANTLLENELSRARAPDDLKRIQLVVSILTITDRNVFGQISDLLRGPSPGDMISIETQADNVTIGGKIYQFDYTGIFPTQNTYPNVDLSKLCVFLCFLKACVRVVAVNNYVDSTPLLDSVNKMTTTVHVASNTHPPLLFLPGSQASGQPEQHTQATTGSAQGRESGRQTRRRARIVQEGESSETASGDAVVYDDSSDDEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8C7</accession>
    <name>A0A1C1C8C7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">alg3</name>
        <name evidence="15" type="ORF">CLCR_05931</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8C7"/>
    <dbReference type="STRING" id="86049.A0A1C1C8C7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05931"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07402"/>
    <dbReference type="eggNOG" id="KOG2762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20028at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT44721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="422" mass="47706" checksum="89BF2C80B26F2B58" modified="2016-11-02" version="1">MDLSTNTIRDFLTNPVHTRWVAPLLLAGEALLCALIIWRVPYTEIDWETYMVQVRLFLDGERSYLKISGPTGPLVYPALHVYIYSILYTLTDAGTNILRAQIIFAALYLVTLALVLACYRRVGAPPWLLIPLVLSKRMHSLFLLRLFNDCWATFFLWAAIYLLQRRKFEGGAFVWGLGLGVKMTLLLAAPAVGAVLLQAVGRGDAVFTGLYIAAVHILMALPFFGQDQDTGLSYFSRSFDLGRQFLYKWTVNWRFVDEETFLSRPFAIRLLVIHVSLLLLFFQTKWVRPSASSLVEFVRKYVGGMREVEERSIAKKITPTFVTDVVLSGMVIGLLCARSLHYQFFAYLGWATPYLSWRSGGHPALVLMMWALQEYAWLVYPSTTVSSTLVVSQLAIQAMFALIAPPVDHISVPPTKAEELRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8J9</accession>
    <name>A0A1C1C8J9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uridine kinase</fullName>
            <ecNumber evidence="7">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">urk1</name>
        <name evidence="10" type="ORF">CLCR_05867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the uridine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8J9"/>
    <dbReference type="STRING" id="86049.A0A1C1C8J9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05867"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07526"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="738517at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002070">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="8">
        <location>
            <begin position="40"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="272"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT44855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="467" mass="52407" checksum="C03FE24109B182AC" modified="2016-11-02" version="1">MSDGTDLKKTSILASARQAAEAADLPQKARYTPPWADMSIIGIAGSSGSGKTSLAIEIVQSLNLPWVIILSIDSFYKSLTPEQNALAHLNEWDLDSPDSIDFDLLVEKLLSLKQGKRTDIPVYSFQQHQRLEKTVSLYSPHIVVLEGILALHDPRVLELLDMQIFVEADADVCLSRRIVRDVRERGRTIEGTIKQWFRYVKPVFQKYVEPQREIADLIVPRGMQNKMAIQMIVNQTRQILKEKSVKHNAELERLGQQVDIYTLPENVIVLGETPQITAVSTILRNPITDQVDFVFYFDRLTALLIEKALDCHNYVAHEISTPQKLVYSGLRSAGTISAVVILRGGSCMETGLKRTLPDCLTGRLLIQSNIRTGEPELHYLKLFPDIADHETVMLLDPQMSSGGAALMAVKVLVDHGVAEARIVFVTCLAGRRGLKRLMTVFPKIKAVVANIIEDHEKRWVEEKYFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9D1</accession>
    <name>A0A1C1C9D1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_05840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9D1"/>
    <dbReference type="STRING" id="86049.A0A1C1C9D1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05840"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07808"/>
    <dbReference type="eggNOG" id="ENOG502SC5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140082">
        <property type="term" value="F:SUMO-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049627">
        <property type="entry name" value="SLX8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094">
        <property type="entry name" value="ELFLESS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="345"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="429"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="253"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT45144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="486" mass="54148" checksum="CDF9BE553D5B19EC" modified="2016-11-02" version="1">MNSSSPDSAAVVIPSRSAGVETFALGSPHEDSRPRASRPPPLRRSSPRLFRDVFNAMPDTASRRQATLPYPVSSPQDPLQSVSRALQSVNQALQDAQQAFHQPRRPRSESEGRSLRTEGETAEQLVDLTTTSSPSAGSAESHYISYTTHPHDSSQAHRTRRFNALNEPIYPNPTQASSPRRSHTFDHELPHPRANVRFWPPYRFGSVRLPRIRPLGEGQLPSAVEEEAINRQRENHSNWERTQARTRERQRIQEQSQEQDSSQHSSQSTMSPPSSSHSRPTTQSSRQRASPPQLEDDPLVDEVDLTAVDDRASLSAALSKQREDAILAQNPGTDAGRTPLTAYKCPVCMDTPTDATSTVCGHVFCHRCIVDTLNWSIDQRREDAPASRKVKGVCPVCRKPLDLKDTPGTGRSLVPLELRLLVKKRKRDADADTGKAKVTSVVKAERSSDDEEMRRGTGKAGKARKRERESTEDAIWRVFTNDNDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9I4</accession>
    <name>A0A1C1C9I4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9I4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06478"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="78" mass="8388" checksum="907F319F093E70D0" modified="2016-11-02" version="1">MDAQGKHAAKGRMPKSSRLRLSSLLTDLGRVSLALLGVLFLLQVLPQVVVPLPDETKPSNDQDQLADCDCANNDACNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9V3</accession>
    <name>A0A1C1C9V3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9V3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11224"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07954"/>
    <dbReference type="OrthoDB" id="4148767at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="133" mass="16126" checksum="4ED532B5E2E44505" modified="2016-11-02" version="1">MRTANTTSPLMLGNLRQELEEERALLRYRYLEGDQYHVFPSLRRRTRKQKEVSKLLQSTVDRVWQEFRNLECPFLIRNSVRAEEVHRGASDLDEKDRGRPERMKHKLEDVEAGLSSDPQRRYYWTHLAHRFIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA18</accession>
    <name>A0A1C1CA18_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA18"/>
    <dbReference type="STRING" id="86049.A0A1C1CA18"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06051"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07957"/>
    <dbReference type="eggNOG" id="KOG2644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448496at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="2">
        <location>
            <begin position="22"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="302" mass="33471" checksum="85857D467B4FE871" modified="2016-11-02" version="1">MTSSSNVETVSGPEKGLIQTAGCLIIGDEVLGGKTVDTNSAYFAKFCFSLGVQLRRIEVIADDEDEIIEAARRMSKNYDFVVTSGGIGPTHDDITYQSIAKAFGLELRLHEPTWAKMRKFSRPHKSQPNFDWDVPSPALTAKMRMAQLPTDPNIPDEQQVIHVKEDLWVPLAVVNGNIHILPGVPRLFEAMLEGYKPRLLPRLKDPEGKGLYRMLFSTPIAESQIADYLTQLAAKVEPKGVKVGSYPRWGKNRNAVTLVGNDREYMDSLEAEVAAGVQGKRVLVEGEDDTDDETDVKKDKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA60</accession>
    <name>A0A1C1CA60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Vacuolar protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">vac8</name>
        <name evidence="11" type="ORF">CLCR_05660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the beta-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA60"/>
    <dbReference type="STRING" id="86049.A0A1C1CA60"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05660"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07993"/>
    <dbReference type="eggNOG" id="KOG4224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071563">
        <property type="term" value="C:Myo2p-Vac17p-Vac8p transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051656">
        <property type="term" value="P:establishment of organelle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061724">
        <property type="term" value="P:lipophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071562">
        <property type="term" value="P:nucleus-vacuole junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903044">
        <property type="term" value="P:protein localization to membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000243">
        <property type="entry name" value="Putative Vacuolar protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000095">
        <property type="entry name" value="Vacuolar protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045156">
        <property type="entry name" value="Vac8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0926">Vacuole</keyword>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="98"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="139"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="180"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="221"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="264"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="305"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="346"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT45359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="570" mass="62248" checksum="A65B4A416DF76460" modified="2016-11-02" version="1">MLLGRSKDNLYEPALADSEREAVADLLQYLENRGETDFFSGEPLRALSTLVYSDNVDLQRSASLTFAEITERGMQERSHVGILKRLTRPIDVREVDRDTLEPILFLLQNPDIEVQRAASAALGNLAVNAENKVAIVQLGGLPPLIRQMMSPNVEVQCNAVGCITNLATHEDNKAKIARSGALGPLTRLAKSKDMRVQRNATGALLNMTHSDDNRQQLVNAGAIPVLVQLLQSPDMDVQYYCTTALSNIAVDASNRKKLAQTESRLVQSLVQLMDSGTPKVQCQAALALRNLASDEKYQLEIVRARGLQPLLRLLQSSYLPLILSAVACIRNISIHPLNESPIIDAGFLKPLVDLLGSTENEEIQCHAISTLRNLAASSDRNKQLVLEAGAVQKCKELVLHVPLSVQSEMTACIAVLALSDELKTHLLNLGVFDVLIPLTDSESIEVQGNSAAALGNLSSKVGDYSIFVRDWTEPNGGIHGYLKRFLQSGDPTFQHIAIWTLLQLLESDDKKLVSLVAKSEDIIQMVKTIADKHVESDDEDGEDGEGEVIALAQRSLELLGKGPKQTLVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAB4</accession>
    <name>A0A1C1CAB4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_05727</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAB4"/>
    <dbReference type="STRING" id="86049.A0A1C1CAB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05727"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08082"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT45454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="542" mass="61271" checksum="8FFD39DF0E714142" modified="2016-11-02" version="1">MFLDQIKDVLQKLPLSFLLILIGVYLVARLGLNRYGGGLNHIPGPALAPFTNLWRFFIVWGRRPELAHIRLHERYGPLVRLGPRVVSVSDPAAISVIYALNAGFVKSGFYPVQQTIAKGRRLYTMFSTTDEKFHAKLRRAVSNAYAMSTLVQFEPLVDSTTLAFLDQLEKNFADRLGPDGICDFSTWLQFYAFDVIGELTYSKRLGFVDRGEDVDGIIKNLEWLLNYAAIVGQMPFLDRLFLKNPLRLFASQVGLVSSNTPVATFARNRIAARQDVEKGQEKPTTPSDGKPGRRDFLSRFTEAHHKDPEFISRERVLALTVANMFAGSDTTAISLRAIFYYLLRNPDDMENLMRELYEAKEKHDATSPDGSFKWNSVKDLPYLSAVVKEGLRCHPATGLTLERIVPAQGITICGKFIPGGTIVGCNAWTVHRDGLFGARPDQFRPKRWLEATPDRKRLMENSLFTFGAGSHTCIGKNISLLEMYKLVPALLMRFEVGGWCATPMVLADVSQIEFADPTKPWKLHNAWFVKQSDFKVRLRRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAM0</accession>
    <name>A0A1C1CAM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAM0"/>
    <dbReference type="STRING" id="86049.A0A1C1CAM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01723"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03509"/>
    <dbReference type="eggNOG" id="ENOG502SGGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4160433at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="15484" checksum="03307E42A1450525" modified="2016-11-02" version="1">MPFKWDAQSERNLLLSAIKVMGNPPATIWDQVAETIGNGHEVNGNACSQKFYKLKKESENLLAEGGRVAGSNDAATPTKTPRTPGSKGTGGRKRKNADIDGVGEVPTPSKRGKAKKGAAPEVEVKTEVENEGTPAVKVERADGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBE5</accession>
    <name>A0A1C1CBE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD dependent oxidoreductase domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_01574</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBE5"/>
    <dbReference type="STRING" id="86049.A0A1C1CBE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01574"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03737"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="12"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="446" mass="49012" checksum="AA7F756DFF90B33D" modified="2016-11-02" version="1">MGSVGVPKRPYTALIAGAGIGGLSAAIGLSRKGVDVTILEGKSELNEFGASIGISPHAVRVIKSYGLEEQFRPNVTENRYIDMRAGADNRILGAVFTNERNTSRILYGEPAWTIHRADYQQLLARGALGYGARILFNAQVTKVDVDTNTVYLADGRTLTADLVVGADGVRSVVRASIPATASAELIPLNEKAYRCSVDKASMVNHPNLAWLLKNHTSQLWLMSGKYVLSWPMPPHKPYDVVVCVGDGCNVPYGYWGIKADPKQVADEFGDACPTIRDLLANIGPCIQWRFAELPPLKTCRSDKGGVVLLGDAWHAMLPHAGVGGSTAIEDGAVLAECIRWAWENDRPISEATKAYEAIRRPRVERIQAASREGVRFLNGENAEMRDAMLAEQLEMERSLLARPEEERRKDPKPPADMSAPFLSPSFFQWLFTYDAVRETQAYLLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBH2</accession>
    <name>A0A1C1CBH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBH2"/>
    <dbReference type="STRING" id="86049.A0A1C1CBH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01754"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03702"/>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650706" evidence="1">
        <location>
            <begin position="20"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="127" mass="14004" checksum="3D01EE020F6C3118" modified="2016-11-02" version="1">MTLGLWVAASWALPHLTTAAAKAGSHPSFLFTNSGLWDRPLADFASLSLQKAAQYNLLLSLRQMAEPKGVHVGGVNIGGLVIEEDAVMNPRNIAQALFELYQQDKPRWQWESKVGDWDEFLGKIGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBP1</accession>
    <name>A0A1C1CBP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_00062</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000018">
        <property type="protein sequence ID" value="OCT45887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBP1"/>
    <dbReference type="STRING" id="86049.A0A1C1CBP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00062"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00042"/>
    <dbReference type="eggNOG" id="KOG4835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1421013at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT45887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="275" mass="30307" checksum="E48D90180B6BC7D2" modified="2016-11-02" version="1">MDTKATIELVDELQENIEDLEDNLGSLLNDSLAATSRKLPLLDRAKLNVLLVYSIESLLFSYLRLHGVPVKEHPVFKELTRVKQYFEKIKTAEAGPESARPAVTLNKEAAARVIRHGLAGNEKYDLERAEREAREKVLANRKLRGLESKMKEQAAQSNEQDMSATDALTQAAQLAAAPLDESPKSGPNLDSDADTDSDEEGEVLEEQPAQSQSQQGQKRKKKPSAATRRAKRRREAALPGASNEEQMNKALGRQAARKAKKEAKKAAKRAETAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBR2</accession>
    <name>A0A1C1CBR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00505"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10028"/>
    <dbReference type="eggNOG" id="ENOG502RYBC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="41238at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000047">
        <property type="entry name" value="Acetyltransferase, GNAT family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF2">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="264" mass="30015" checksum="6CCB96E90D5E9EAD" modified="2016-11-02" version="1">MTETRSSQQEERNLMGCKEQRQQPIGPSVSLSQPGPGPRPSKVTLAGHAVTIVPLAADHAGDLYDVVKGGDHEHLFTYLFDDPYPSLASFEEAVVTKSQSQDPLFFALVDNTTSKPVGWASLMRVDTTHRVVEVGNILFSPRLQRTKAATEAMYLLAKYVFEELGYRRYEWKCDNLNGPSKRAAIRYGFTFEGVFRKHMVYKGRSRDTCWFSMVEEDWWERGVKQGFEAWLNDANFDGQGRQKRRLEDVRGEMQGQKGPVVLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBR5</accession>
    <name>A0A1C1CBR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBR5"/>
    <dbReference type="STRING" id="86049.A0A1C1CBR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00425"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09524"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10060"/>
    <dbReference type="OrthoDB" id="5308957at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="26"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="470"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="528" mass="59542" checksum="1809165474C3D619" modified="2016-11-02" version="1">MLLMATRLTPSSRPGSKPVHLRPSKPSEWEPFRETLERLYVQQQMPLRSIIEYMKDNHGFDATVKQYKNRLKLWGLQKNLTRRDAAFILRLLNQARSEGREEVVFFAGTARRRADIVKYVRRHEKLDGEYGLLSCIAGDESTPAYIQLPPANVEFGQPNTPQPSPTLPLMVSGTPIQSEATPSHPFAGPSDLNGHQSNIDTTRSTLPSLSTSSNCFTRAAFHHEARGFEFNASPADVDNIQAPGYNSNLPVWHQYGDVTGLLPLDSFAFPSSLRLKCPQAPAPTRTCSPDSARSSILRYAFLPAVLISEHLRGTSPGLWLVAQPTLQECRTLPDAYVLSKCVDILAWTQISNQIVSLAVIYLLRALLHTSGTFHSVWTIWIACVRFAQIHLEDESSEIHVWQQVLRGMGESIRELTQAEILLLTCSGLSFVVGPDEWDVSTQRLERVCGSCIQRLDTLLSNVTPSLDTISRWEQHKVEIGQLYQHHSLEEVVRLMKERHHFAPRQRIAEWGFKKRQATSLTRGPECHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBW7</accession>
    <name>A0A1C1CBW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uridylate kinase</fullName>
            <shortName evidence="9">UK</shortName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:UMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate kinase</fullName>
            <shortName evidence="9">UMP kinase</shortName>
            <shortName evidence="9">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">URA6</name>
        <name evidence="11" type="ORF">CLCR_00515</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Predominantly cytoplasmic.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBW7"/>
    <dbReference type="STRING" id="86049.A0A1C1CBW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00515"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10035"/>
    <dbReference type="eggNOG" id="KOG3079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="47"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT45976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="231" mass="25121" checksum="738B7FC7198785F5" modified="2016-11-02" version="1">MAAPPAIDPTSGASPLVQPDVPLASTNISPAFDPQKVTVVYVLGGPGAGKGTQSANLVRDYGFVHLSAGDLLREEQDTEGSEYGQLIKDYIKDGKIVPMEITVKLLENAMRSNMGRDESGKFLIDGFPRKLDQAVFFEQSVCPSRCTLFLDCPEEVMRERLLNRGKTSGRSDDNEESIIKRFKTFVETSMPVVDMFEKDGKVVKVSAVGDVGEVYEHVVEGLASMGISPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCB3</accession>
    <name>A0A1C1CCB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCB3"/>
    <dbReference type="STRING" id="86049.A0A1C1CCB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00427"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10321"/>
    <dbReference type="eggNOG" id="ENOG502QU74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414774at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="562" mass="63069" checksum="53BBAEC65A2198C4" modified="2016-11-02" version="1">MSLPSTLVNASSEPKEYFDLGSFHRPVSTASREAQVWFNRGLAWSYGFNHEESAECFKKAIAIDLGCAMAYWGLAYALGPNYNKPWEFFDGGELQSVVERTHAAVEKAKAEAANATAVERALIDALEFRYPQAQPAVDCSIWNRPYADAMQAVYASFPEDLDVAALYADSLMNLTPWKLWDLSTGKPAPGARTVEVRTVLERALSHSSGLEHPGLLHLYVHLMEMSAAPEVAMPIADRLRGLVPDSGHLQHMPTHLDILCGDYRRAISSNMDAIRADEKFLARAGPLNFYTLYRCHNYHFRLYAALFAGQSRVALETADWIEATVPEELLHVESPPMADWLEAFHGMRAHVLIRFGLWQDILDLPPPKNQELYCVTTALFQYAKGVAFAATGRLEEAGKQRTLFDEAMKRVKSTRTLFNNVCLDILAIARSMLQGEMEYRRGNFDAAFKHLRQAVSLDDSLPYDEPWGWMQPPRHAYGALLLEQGRVEEAAAVYSADLGFDDTLPRALRHPNNVWALHGYHECLKRLGRAAESRLVKPQLDFAVAMADIPIKASCFCRTDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCC3</accession>
    <name>A0A1C1CCC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative prolyl aminopeptidase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCC3"/>
    <dbReference type="STRING" id="86049.A0A1C1CCC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01299"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09403"/>
    <dbReference type="eggNOG" id="ENOG502TDBC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="18"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="265" mass="28415" checksum="8F198BFB46E288A4" modified="2016-11-02" version="1">MAESNATATQSLTSKPTIIIVHGAWHRPIHFHELSTALTSHGYKVIVPALPSVDKAPGEITPDGEADIATIRHAILAELDDAASPNDVILVPHSYGGIPSSGAVRGLDSASRAAAGKRTSVRAIAAITAAILPEGMNITGPDGEPAVREGLPALMNPPPATMFWQDVPAESETYRQAETNLNAMSTAALFDPCRFSAFEVVDVHYLLARDDQALKFHVQEAMVRRIRERGHVVRTEVLEACGHSPFLSRVPETVAFVRRSAGEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCW0</accession>
    <name>A0A1C1CCW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_01334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01334"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="177" mass="19579" checksum="BAA899F27D888D3C" modified="2016-11-02" version="1">MAEQSPPSPAIVAEDSLSVPAPEAREVLRKCLFCGLWNPSRVTICDRCACITLPSRDAQQRRIKWTFHAFGPSAPFSKSITRSDFEAMLQRTESSENNAVYIGDEKRKVLLAHYPGGRRRFSTRTIDALGNVHTHTLELDSDNGSNRAIFNRAVNEIMDATGMTPGHKSLSPGLSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD17</accession>
    <name>A0A1C1CD17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_01345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD17"/>
    <dbReference type="STRING" id="86049.A0A1C1CD17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01345"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09182"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="121" mass="13039" checksum="A686B60ACCC71F0A" modified="2016-11-02" version="1">MIEASSPLAAMQPPVFMGHCGGFRADAPPSYASFAAAKSFGTNSFNFRDLSMKKSQPDYFSLKPVRGSSPTASLAADLSQNFHIDQSPQLPTPRRSLFPNGLFAQEGHSEWLLIGKTGFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD59</accession>
    <name>A0A1C1CD59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tafazzin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD59"/>
    <dbReference type="STRING" id="86049.A0A1C1CD59"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01163"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09098"/>
    <dbReference type="eggNOG" id="ENOG502S698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="60018" checksum="2BDF627340948D93" modified="2016-11-02" version="1">MPKKHQQRALQIKPQSSSPHTLSLSKSPRPQHEGSSQRSVNDLIRESRRLQLRSEARTPPVLDNAHSLHPSLRAVLDLPPPPSPVPRYAPGSRSSGSSPGPSRLRRIPGPPPPRSWLTDSIHAPPSVRSLHDPAHGENRRIQVRTSNLPDGAFPLPGSLQHLVLKKIASEWEWHADNDLEYFNYLPVRLRETLLSYIAVFGDHVRSDPLRILLLHETEIEEKDEVGRLDLSNAIGHWTTFRQLERDLVAKNAGPVTGSVAFVQAPPIGYAPESWDAESDGDEVSNATMIPPVPKTAPNFVNLKHLSLAIPSGSAKAASWSSLLSLATDLRTLTSLSLAYWPQPTFTPNAASTRVVLQTPGPGPVVYGGSDIYTSHDNNWREAAGILRTLSRSLYCLKWLDLTGCGDWFAALQWVPSPSSSPSSSPTSGSLSVPHREYLAPEWNGGWRGLEKLILEVGWRPVAPPAIEDYRLFTSETSSWNVENERRLYRYRKDRERFADIRRTARSVARHLRAVRKNAGGKWIDVELGEDLEPLVDSKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDK4</accession>
    <name>A0A1C1CDK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="16" type="primary">psd3</name>
        <name evidence="12" type="synonym">PSD2</name>
        <name evidence="16" type="ORF">CLCR_01792</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDK4"/>
    <dbReference type="STRING" id="86049.A0A1C1CDK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01792"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01332"/>
    <dbReference type="eggNOG" id="KOG2419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04024">
        <property type="entry name" value="C2A_Synaptotagmin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000445">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000198">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023264317" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023264316" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="12">
        <location>
            <begin position="1092"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="131"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="363"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="615"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="108"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="302"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="481"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="710"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1150"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1150"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1180"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1190"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="947"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1005"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1092"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="1092"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="1091"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT46603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1199" mass="133394" checksum="EADC3B4B76C75161" modified="2016-11-02" version="1">MSVPTSPQTDTLQRSHTRYLSSNLFQVSSPRESYPVCLHHDNDPRRSFSVSLAIAPGSLSGAVHFSSSLTIQPPPLLVRNPAIVSVNNRDIAQDVEMVHISLPKGLSSLAKHKDKERSGNGASSNGDGGGRPSPPRLGSNNNSTAALVDQKPLILKVYVIKARNLAAKDRSGTSDPYLVVTLGNARQSTPSISKTLNPEWKICFDMPLTGVPLLECICWDKDRFKKDYMGEFDIPIEDIFPNGQIQTQPHWYKLHSRRPASKKGSNVSGEVYMQFSLVDSANPSASPEEIRKKFQAYLGAEEEDDELSRVSSNLDDPGMDDDLDPEDLDDDQESVTENESPHKSALVDKKAKKKRLARLRRRSIAARAYNFLGDDNDVNGVLFMEVIKITDLPPERNMTRTSFDMDPFVVVALGRKVLRTKVVRHNLNPIYNEKMVFQIMRHETGYSLTFSVIDRDSLSGNDFVASTSFPIQKMIANAPQEDPETGLYDLPEPPEYSPAVQQKGRFRIPLSRTSSASSLSKSSRPGLKKEDSNVSLSNLSTHEALRPPPPTSMPSENNSIGSKGPGLDPPAAQPADDPTMTSYVIPLELKNKERWEAKHSPELHLRGKYLSYKALRQQFWRAMLKQYDVDESRRISKIEFTTMLDTLGSTLKESTIDGFFRRFAAENEDIGEVDLTFDQAVICLEEQLQRSSQKKSQLEKIKSAEVSHDVIPENPPVNADVPNIPQESTGTPGEEGRLLGNDLAEEEADEEHVIEIRECPICHQPKLNKRTEADIITHIATCASSDWRQVNNLVMGGFVTQSQAQRKWYSKVITKISYGGYKLGANSANILVQDRITGQINEERMSVYVRIGIRLLYKGLGAGEMEKKRIKKMLRSLSVKQGKKFDDPASAAQIPGFIAFHQLDMSEVLLPTSEFRNFNEFFYRALKPNARPCSAPDRPEIITSPADCRSVVFNTIDDARRIWVKGRDYSLEKLFGDAYPLDAKRYKGGSMGIFRLAPQDYHRFHIPVDGVLGTPKAIEGEYYTVNPMAIRSALDVYGDNVRVLVPIDSVAHGRVMYVCIGAMMVGSTVITRKPGERVKRAEELGYFKFGGSTILLFFEPGKMVFDEDLVANSSGALETLIRVGMSIGHSPNVEPHKPDMKKDEANITMKDRQEARRRIEGSLAPEMDNMGLLPDDTDVGDAAGDATGGMSSLNPANLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDS5</accession>
    <name>A0A1C1CDS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">oca3</name>
        <name evidence="6" type="ORF">CLCR_02051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EMC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDS5"/>
    <dbReference type="STRING" id="86049.A0A1C1CDS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02051"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01408"/>
    <dbReference type="eggNOG" id="KOG3060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="112"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="313" mass="34307" checksum="33CFBCDD2FA88D21" modified="2016-11-02" version="1">MAVVMPKGPASDPASALQIAQGAPAILAKSSSVSTTFPASMFNTADSAELWDDLEQLLYACLRTGDDKSAFLCVERLSQRFGATNERVMALRGLYQEATAPDEAAGRKILEDYAKILMENPMNVPIHKRRIALMRSLGKPQDAISDLVQFVDSFPTDMEAWCELSDLYHSQACIPQAIFCLEEALIIAPNAWNLHARLGELEYLASLCVTESAEIQKHLTQAIQRFSRSIELCDDYLRGFYGLKLAADKLLRTTTTSKGNTGSTIPPEKLQKLSQLATSKLDAIVKDHTARRSSGAESPEVIAAQELLNRSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE71</accession>
    <name>A0A1C1CE71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_01818</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for assembly of the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE71"/>
    <dbReference type="STRING" id="86049.A0A1C1CE71"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01818"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01545"/>
    <dbReference type="eggNOG" id="KOG0242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000073">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 12 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="222"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="833"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="619"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="837"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="849"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="882"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="902"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="926"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="303"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT46830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="981" mass="105421" checksum="9B11CA1ED55F3D30" modified="2016-11-02" version="1">MSLPVLSRPLADPPTGALPPIPTSKTPRKSLGQTPSRLKQPSRPSALPTSQPVQSTPDLSPEKASGTSGGKGVRKTVSIGSFPQPPNANSRPPTSASMASNTSIKKRTSDGGNSVQAHSGKSKKSPRNSTAPSFRASQTPSLLNSAGDGMTVSARYNKRTSDAQSSVHSPPQSRSSSANGSYSTSATTFEEGDEDSRGRTKELEDSSADPKTLSKGKEVKGNVIVSVRVRPDAGAQNNTQTEGEWMVDGRRALVAYGGKEGGDYHLDNVFTTHDDNAKVYDSAAKRLVRRVMEGYHGTVFAYGMTGTGKTFSMQGTMSSPGVIPLAITDIFSYIRETPHREFLLRVSYLEIYNEKIHDLLAVPTGGAVGQQQEEIKLREDSKRGVYASPLKEEIVQSPTQLLRVIHRGDQARRTGSTQFNSRSSRSHAVVQIVVESRERIPGSGSLQENGKRVAMLPGGVRVSTLSLIDLAGSERAAEDKERRAEGAHINKSLLTLGTVIAKLSGTRDKNGNLVDKDGKHLPYRDSKLTRLLQPALSGNSLVSILCTIQIGAGLASAGSNHIGETLNTLKFAARAKNNIVSHAKKAVEELGSVNSGLLERYRSEIASLRAQLEGQQKSAAEKEERQLEREAEQRHEEQMLEMQLARTALKERIEHLNRLILCSKSTGVNSGTVSALGMHSRLSNGTEFGGSRSVRSSASQSTLGVAPSLGRHPSVASLGGVASASAHLSFPSIPDEDEEAGGDFGDGRASLQAQVRALQADLQDKTRYISTLEKRLLQARRSSHSRVSMAFNKPTGDETEMQRRLDEKDAMISDLQKTVSALRSAVRKREIAELTPEMSSSEFKQNRAQGHQSNSSNSSSQTGSQLSGPTHPILPGGPRSPLTASPLTILSPQKAMDKKRKTVDEMSRMLDEMIQDKVESGKLNNRRSSSVRVASRGSSAPRRHSRRMSVAANSPTTGPGLGTMVASLREHDPVLEPSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEJ4</accession>
    <name>A0A1C1CEJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_02332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02332"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02485"/>
    <dbReference type="eggNOG" id="ENOG502RV2I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT46933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="567" mass="63719" checksum="F50766788C8B3190" modified="2016-11-02" version="1">MAQGRAKRPHQKVKTGCMTCRKRRIKCDEAKPACRQCTDSLRKCEGYQPPQTWLFKPRKAVDNKDDSLGNGMTTTIVQFVSPLGPVGNSSDRRSFQFWHEQAAPIFSSYFGHSFWTDLLPKIGLAQPAVKHLLLATSSLVESAALEGVPIDKNTVYQTHYTKALQATCASPQIESVLMACLLFACCEFMKGSIQSGLRHIQAGLNIIDEWVKSTQQTDLQISSAAKLILQTIGPIFLAYIDKAPTYGMGDVPVKECACTTIITGEAELPCVGQFTEIHLALHALDGIGHHIARLTDYRRPAWTPSPRHKVQTLLESWRMHFETFEANLMDTRRQRFALALQVLRVHYTMLSVMLRASSSKHESVYEQFSEEFKWIVDKYDDFAEAWKRDESTKILGGTGNLDYHMGYIPPLFFTATKCRDPATRLAALKHLGSLRVVENNWTSCTAYLIARKVIKIENTRALNNKRAGLRDERDLIRPVEAFISDKHNKQAGLDYVVFPYDSTPMMQDTIDLQACPWSASTQWPLSRIIRIGGYQGGAVKPALTGCVCGLQYPRETLLLRAKPKVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CES0</accession>
    <name>A0A1C1CES0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_02312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CES0"/>
    <dbReference type="STRING" id="86049.A0A1C1CES0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02312"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02439"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF4">
        <property type="entry name" value="CYTOCHROME P450 98A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT46982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="555" mass="62951" checksum="A16386303494F879" modified="2016-11-02" version="1">MGVMVHLQSTAPSASQIAICLVLVGIIAVAIDYARMLLLRQKMPPGPFPWPIVGNTFQLPDVKPWILFETLARQYNTPVITYWIGRSPTVWICEAQAASEMLDKRAAIYSSRPRMVVFGELSFGQSNIVSMFYGDRWRLHRKLTHMGVGLQHVRSYSGFQNNESKVVALDLVRDPADYVMHFERYAASVVSIIGFNRRIKDKEDPIITDVIAIMQRAAELNVPGKKFPMLMETFPVLSKFPNWMAPWKHGLGRGRGRGKNFYYALAEEAANKENHGNCYAKKLFEEAPKYGLSDMEIASLNGNLFGAGSDTSSSTLITFVLACCAFPEVLPKAWEELDRVVGSYRSPGLDDDLPYIRAFVKEVFRWRSVAIIGGQPHANIQDDWYNGWYIPKNTWVQGNVWAIHRNPKDFPEPDRFAPERFIEGHPLHRPFPNEKGYMTFGWGRRVCSGQGLAEQGTFLTVARLLWGFNIQKALDKNGKEIPVDIFAYTNGLNMRPEEFECRITPRSPEIKETIEREGKQALAELAQYDGESKYRASTFYLQDNTKFSSSTATSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF17</accession>
    <name>A0A1C1CF17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinate--hydroxymethylglutarate CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF17"/>
    <dbReference type="STRING" id="86049.A0A1C1CF17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02317"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02324"/>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="463" mass="50179" checksum="194EA2A61A05ADE7" modified="2016-11-02" version="1">MAPSRAARHTLALCRVRVFNSSRQRPLDRASSRPWISRRHFASTAESSATATATTKATKVSPLQGIRVLDMTRVLAGILGDLGAEVIKIEHPTRGDDTRAWGPPFAKYKPDAAVKGDRPGESAYFIGVNRNKKSVGLSFQHPDGIKILHDLAKTADVLVENYIPGSLKKYQLDYESVRTLNPSLIYASITGYGQYGPYASRAGYDVMVEAEMGLMHITGERDGSPVKVGVAVTDLTTGLYTCNAIMAALLARQQTATGQHLDVSLSDCQVATLANIASSVLVSGERDGGRWGTAHPSIVPYKGFKTRDGDVMLGGGNDRLFGIICDRLGKPEWKSDPRFASNDARVRNRAVLERMIEDVTLTRTTADWLAVLEGSGLPYAAINDVKDTLEHEHVQARGMVTELEHPACGPVKVVSHPVKYSESLAGVRSPPPTLGEHTDQVLREVLGMEAAEVERLRTDGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF54</accession>
    <name>A0A1C1CF54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF54"/>
    <dbReference type="STRING" id="86049.A0A1C1CF54"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02518"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02265"/>
    <dbReference type="eggNOG" id="ENOG502SY1T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4154548at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="336" mass="35216" checksum="0162AAD9846E08E3" modified="2016-11-02" version="1">MFQASFRQHGKRAPQRHQRPEFDSDAAAQTPTPPSTTADMTTPTTSAATTAGPDAATDMPHALLVYPTVRMTLNNIDEVQVGYRSIWRSVNLTVFCEMGEASNEFSLARMNKLQSNGTYAIAPIQAGMQIPHFPTYCNFMLCDAENSTDYTTGAGFTMISTQGIATTYALAITQAATASPSGTHSPISTVSHTESTLTGAAAVTSSTAVQTAVPSSSHSAVLSSGAKAGIAIGVILGAALIVAAFFFIRIKRRIDKLETMVTLRSAASSVDRTPSEKGTTAGAVATPAAVAASPSPPPDGCGPRIEVFKIGDSHRNSEDWRRFFGNGKGPKPVAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG13</accession>
    <name>A0A1C1CG13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Integral membrane protein SYS1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SYS1</name>
        <name evidence="11" type="ORF">CLCR_03683</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG13"/>
    <dbReference type="STRING" id="86049.A0A1C1CG13"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03683"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01975"/>
    <dbReference type="eggNOG" id="KOG4697">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT47401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="195" mass="21728" checksum="8D665CCE48FE7B9F" modified="2016-11-02" version="1">MPRPRRKPPRSGALTELPPLKILRSILVLQLWYYTTFFIFAVFVSLVLGQEFSPDWVLDWRSVRGDNTLGWTVGFLCVVNGFVTVIPILVFISRSKLVPDFALTLHFINLLVTSFYSGAIPTNLLWWGLEAASAALMIVTGVWACRYREMQPISFGTLATKKTVNPTGDPANGSAEPLMGNNSYEMGNIRGDDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG71</accession>
    <name>A0A1C1CG71_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">40S ribosomal protein S18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RPS18</name>
        <name evidence="8" type="ORF">CLCR_03709</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG71"/>
    <dbReference type="STRING" id="86049.A0A1C1CG71"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03709"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01937"/>
    <dbReference type="eggNOG" id="KOG3311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="155" mass="17851" checksum="A08925A5C92416EF" modified="2016-11-02" version="1">MSLVSGEKSNFQFILRLLNTNVDGKQKIMYALTRIKGVGRRYSNLVCKKADVDLNKRAGEITSEELERIVTIIQNPTQYKIPSWFLNRQRDIVDGKDSQVLANGMESKLREDLERLKKIRAHRGLRHYWGLRVRGQHSKTTGRRGRTVGVSKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGC7</accession>
    <name>A0A1C1CGC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03472"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01826"/>
    <dbReference type="eggNOG" id="ENOG502S6BE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4156714at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="510" mass="57930" checksum="CE4876BF913B6E2B" modified="2016-11-02" version="1">MYSEIARWALIEDKGTVSGGRHDQDGRHDQHTRLEDTARPLSGPPQVPPKDHGDQQLAKGRGSSQVATQSVEYGPGSVHQVTFVPAARRGENEQSHNNVLQKHANASDYQTKTIRDQEDEIRKLKEQLSETKAKPRSNDLRRYEDRAATAEAKLKFANEDIHYWKARFEQCSHDATASLRDMDQEKQRLQRDLDQSEANVRALVEAATRNMSSGRWNPPPDDDIRNELNRLHGMVRDWAKDWAVDGLPEHRTQDPEYISFKQNYLAEFVWANDRGSLPPAIDSPAGKLKQRLPDLLLTAALSHTIHDAFFTNAFFCAPPEFAGALRKVYEELILANQREAHGWRCTFWRIMNPPKSGKSAANDESATFKRVRLYCDETARSFRHGPAEKLLQRCSSEESKTQAKQLREILMNAAEIATSLWTQPSYIECLGLHEMRQRQTVFDVTSPVMEAHRLSKVDPENPKHNGRRIMAVIQPALLAFDENDPLGLDGDGYRVLSRANVLLDELSSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGJ6</accession>
    <name>A0A1C1CGJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">(R,R)-butanediol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BDH1</name>
        <name evidence="7" type="ORF">CLCR_03549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGJ6"/>
    <dbReference type="STRING" id="86049.A0A1C1CGJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03549"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01800"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000721">
        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034079">
        <property type="term" value="P:butanediol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08233">
        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF23">
        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="11"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT47586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="356" mass="38671" checksum="0223E0860192D8B1" modified="2016-11-02" version="1">MSTMRAARFYGNRDIRVEDVPVPEAGPGECVVEVEWCGICGSDLHEYAAGPILMPTVDPKTGDPKPITFGHEFCGRLKSVPEGSKLKVGQAVMVDPHCICRQCLCCTSGNDQMCQKLAFLGGSNKLGGGLSEFVAVEEAHCLPLPDTVSLEYAAVIEPLVVCHHAAKVAAVNLKGLAVLILGGGPVGSALISILRAHEVGRIFLSEPTAKRKEQNKDAVDRVIDPRSEKVGDVCRELTGGKGVDVVFDCAGVQPGLEAGFDALKHSGTFVNVAVWEKPVSLIQIQFLIFFFKEINIRSSCCYNEEDFKEVMELMSKGYERMVTSRISLEDTQSKGFEELITNKDDQIKILISPKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGS2</accession>
    <name>A0A1C1CGS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">atg4</name>
        <name evidence="14" type="ORF">CLCR_03467</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGS2"/>
    <dbReference type="STRING" id="86049.A0A1C1CGS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03467"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10378"/>
    <dbReference type="eggNOG" id="KOG2674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 11 14" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="124"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="36"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="453"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT47666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="533" mass="58525" checksum="8789F0DD62CFAF9B" modified="2016-11-02" version="1">MNGVEIKRFVRYFYDPPPKYDDMSGTSIWLLGKEYKATPPKPVTTTDHDDVVEVESSSDSHEPSDAASAPSTAPETQQQQQQSQQNASESQNTSSFDDAQLVTGGEDTPSLSNDPSDRGWPIPFLDDFESRVWMTYRSNFTPIPRSHDVDSSTGLSWSVRLRNLTEREGFSSDTGWGCMIRSGQSLLANALIMLRLGRDWRRPGTHTSRTASPPPPSSEPPTYTSSSTQTEASILSLFADSPSAPFSIHRFVHHGATSCGKHPGQWFGPSATASCIQALSAECASAAGLRVYVTPSASEVYEDKFRSIARASATDATITPTLILLGIRLGLDRITPVYHEALKSSLTYPQSIGIAGGRPSSSHYFIGCQGDLFFYLDPHETRAFLPYHASSAEYTDEEISTCHTRRLRGLRISEMDPSMLIGFLIKDEDDWEDWKRRLKETKGKAIVHVLDKEPPVPGESRERKEAVDEVVSFDDEEEDDETVTVTGKEDEEGVQVEASVAASGIARSEAETEAGDDAVKVSVPQRDTAVEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGS3</accession>
    <name>A0A1C1CGS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hpc2-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGS3"/>
    <dbReference type="STRING" id="86049.A0A1C1CGS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03377"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10393"/>
    <dbReference type="eggNOG" id="ENOG502RG9A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="486"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="613" mass="64931" checksum="0A9F4F9227F784FD" modified="2016-11-02" version="1">MEVDGRSSSLDSLSSAPPSDAEGTPGPPYYLPTHRNTSAATALGGANNHDARQPHADPGVALAATTEGARQDPQPVKRPRKPRAPKDLNAPPAEKKPRVSRKPRTAINNTTSRKRTKVEPIEDDSTIVIPGPPTSGLQSSTLVQPVSFAHQPPVESRRNEAAKTSEPGFSIQDRSMHPYTSPQNTYEQKPNVLAPPPPQSSTPRSKAMYDPIRESTQRPLDTNPPPLMAQPVMTPPRPTYNPSTSPAISGIIDYPPKAEYSSSATLVTHPPRVEPPSTHTNGRTIDSPRAADPSAMDIDLAEKEQAQPKKATASRKIPSEASTRATSPKPARAKEPPPPPPMGSGLLSASLFGGDSSNGIAQKDSEKGSNIVLHVDLKDPNNRVINFARMAEEKYGFAALYPRQAAQKERLAKIAAAGAALERSASGSKLGGTSAESGDEDLSVDIDRDSENDGDVAMSGVNGRLEAGNSGTDGPGPKPQRRRKVEEYDVDDDFVDDSELLWEAHAAASKDGFFVYCGPLVPEGEKPAVERADGTIKRGRGRGRGGGPGSRGGRGGAAASEGGTRRGGGPGSRGGGTTRKPRITKDERAQMEKEKLQREKMASLVPKPSAYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGY0</accession>
    <name>A0A1C1CGY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGY0"/>
    <dbReference type="STRING" id="86049.A0A1C1CGY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03492"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04569"/>
    <dbReference type="eggNOG" id="ENOG502S9P3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5590473at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18724">
        <property type="entry name" value="PIN_LabA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF5">
        <property type="entry name" value="NYN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="56402" checksum="F42AFEFC0E1F34A4" modified="2016-11-02" version="1">MTEVESLSWDLNDAITLLNNLSFQRHDPAPNHRTAPHSNDTLAEQNNAEGSLGDFSALWDFLGRPHVPDEAQTAELVKYEINDEAVAEVDLNQLNKGVRWRDEVDGADLEDNVEPTSDKATAAYIRNQKRAARRAKAKEKAAQLATLQKTASDTTDHESGEELESLRRSPDRRAVIDRILGRSRPGLHDNSSPPTSPSPPTAELRTPKRDLPVSNPFVWNGPAISTPSKNTIIAPRDKLSPRERKHALITELIHQYPGEKKYLKNAGLLEPAFTPLNVSNIGIHVFVDMSNISIGFHDCLKIARGMSRETRLKRVPLSFHNFSLVLERGRPAAKRVLVGSDKYAAIQKAKSIGYETNILERVHKAKELTPRQKKYQSRSGGETSGSETNTGLPSLTFGAEKWVEQAVDEILHLKILESLIDAKKPSTIVLATGDAAEAEYSGGFLRMVERALEKGWCVELVSFKLNTSSLYKRREFRSRWGQMFKWIELDPFVEYLIDEEEDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHD8</accession>
    <name>A0A1C1CHD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03246"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04475"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04476"/>
    <dbReference type="eggNOG" id="ENOG502RZBP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4149590at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650822" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1526"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1579" mass="152370" checksum="89A8F3540F614EBF" modified="2016-11-02" version="1">MWPSSSLLLPYLAAHIASVGAQALSTVTYGPSGPCPVPSVTSVVVVQAGYYSSFFQSASSIVNLWGNGNTVVINNAPTTYITNTYISTTIISTITTTVVNPSTTGASSSGADVGPILTGGSSSTTPATSASMTPMPPSSSTSLGPSSTSSPIFTPIPPPQTTPAPAPVLTSTSVDANGNTVLVQVTQTPLALGEGFPSGTITDLPASLAESGIIVGVAVNGLGAKVKRQAPAGPTAGAVLSGDEGGAALACDVAVRYFLERGELTDGTDVVGRNTTDNSALMTPDPDFNNVTTVLSFVDGILNWNSADRGAATFYQCGDAKVYAGFPNPPKDDCYVVTLGGIAATACPVPLRDEADTSTSTDIPSSTPAPSEVSSTTAIDVTTTTDSGGTGQTTTPETVSSTDQTSPSASLSSSEALPVSSTVEQTTPSVVATPTSAGTSVASATGGSVVASSSSSSSVVVPPSSSSPAIPQSSSAAATIGQSTSSPGPVAQSSSSSVVPAQSSSSAIVPVPSSSSSASSLRSSSTAVVPALSSTTAVTSTASSAGGAAGSSSVPAGGSSTTPVINPSTNPATSALPPSSTAPSSPASSTSAGIVSSSPSPSTSAPIASTTSPSPSSSSVVPPTSFSATAAGSSSTTIAGLSTTAAATSQIASPVASSSTSPIVAVSSSTIAVSPTTTAMATTNQGTTQSSAQSSAPPFSSSTPSIASSSGTSPAVVSTSTSSVVVYASTLSSALGSSTTTTGISTLSSAPIVSPPTLSSTPVATAPTSTSALASSSSAAMSSSTTSSVVIAASTSGVLPITSTSSSGALVSTTVALSSMAITTAPFVSSAANPTSSTAPPSTISSAASSATTSSSSALSPTSTVVSSSIASSAGSSTTASVIQSTSAMSSAYSSLSTMSQGVSTSGAGLTSTTSTGLTTTGGVTSLSTVITSSVVQTSSPGSVVTTTAAASTTISSVASSTVQTSSGAASSSSAASSNAPGSSSTAATSAASSTIIPTSATTTSTAAPSSTVSSIAVTTSSLASTLSTASTAPTSSNAALPSSTISTAAGAATTSSTLSTVETTSSAAAAISTLSTVTSAATTSATTSTASSVAGAGTTSTISSASTAAPSSTTSPINTTTPSSSTLVTSVATTTSSESGSSTTLLTSSSLVSSSTTVVTSASTVAPTTISTTVAPTTVSTTTTAIATTTMTTSAAAAVTSSTTTTLSPSPASSSTTTSVASYSPPAGPNASSLASTVLVAQVTPAAASSGVLCAGVNFQTSPTVQPLPVQTGAYNYQKVALSNAPNAVYEIECFMSSASGTAPPATPNVNSLEACMDLCNQAGASCAVAYWASSLAQCSLFPTQSGSGLLTPNSFVGNYVRTARLLTPTSPNVIDATYLLAPGYDLNLCGGPNANYYDRTFVGVYGRGASGTGGPFIQGGSRNDVFLITCAGYSYYTSGIAGSQVVTSTAATTYGFGGVITTADDCARLCEILNAAANYGGGCRLFEWYGSNTCNLYSSRPGFSNAPAVRAGVLAAGISRASASSEFTAGNGGPQSYRKRSLPPGVGSYRQHPRDALAETDYLTPDVILQYSNSSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHL4</accession>
    <name>A0A1C1CHL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_03934</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHL4"/>
    <dbReference type="STRING" id="86049.A0A1C1CHL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03934"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08164"/>
    <dbReference type="eggNOG" id="KOG0102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="632"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT47998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="663" mass="71845" checksum="CAB1439A5481FA9A" modified="2016-11-02" version="1">MIASKFSRAIRAPRSSIISRYASTDAPETTEKVKGQVIGIDLGTTNSAVAIMEGKTPKIIENAEGTRTTPSVVAFTEGGERLVGVAAKRQAVVNPENTLFATKRLIGRKFSDPEVQRDIKEVPYKIVQHTNGDAWLEARGDKYSPSQIGGMVLSKMKETAEAYLGKPVKNAVVTVPAYFNDMQRQATKDAGQIAGLNVLRVVNEPTAAALAYGLEKEDDRVIAVYDLGGGTFDISVLEIQKGVFEVKSTNGDTHLGGEDFDITLVRHIVQQFKKESGLDLSNDRMAIQRIREAAEKAKIELSSSIQTDINLPFITADASGPKHINIKMTRAQLEQMVDPLISKTIEPVRKALKDANLQAKDIQEIILVGGMTRMPKVTESVKSIFNRDPAKSVNPDEAVAIGAAIQGAVLAGEVMDVLLLDVTPLSLGIETLGGVFTRLINRNTTIPTKKSQIFSTAADFQTAVEIKVYQGERELVRDNKLLGNFQLVGIPPAHRGVPQIEVTFDIDADSIVHVHAKDKSTNKDQSITIASGSGLSDAEIENMVNDAEKYGAQDKERKAAIEAANRADSVLNDTEKALKEFEDKLDKTEADTIKEKIASLREYVAKNQAGEGTATAEEMKAKIDELQTSALTLFDKMHKAREESSQTPPPGGEGGAQGGEQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHM3</accession>
    <name>A0A1C1CHM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHM3"/>
    <dbReference type="STRING" id="86049.A0A1C1CHM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04037"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08134"/>
    <dbReference type="eggNOG" id="ENOG502S0Z5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4092340at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="544" mass="58092" checksum="68F191546DDAFC55" modified="2016-11-02" version="1">MSIDAGGLAQMTYQSPFNGSIGVSGPGFASRGKGSHIKRLSVAPPSKISTIDETQQANTVSTPRTSRGHLLAGLRTAPKSATVPPVTNGPGLESSRYASVQYGNQAPQTATGMYFPQGRNSFHGNYQQQQQQRQQHHYSLPEHVLAPPSLEFVGEAENMDQTLYDELVATNNYLAQQQRALQQQLLSVTAAAHQFSGLNLNTAFVNNAGQQQFQSPISSPMGLYNQQLQQGLQPMVQPVPGSPGVFAVYNPMTGQSSYVVDNSYQQQQPQEASSTRQKTSASPPPAVPGYQRQVPEPNFPQTETRSKTPPKSTPSPPQDVEPLPPPSANAFRRGHRKNMSSANIKTNTEWTKGAGARAGFPQTPLTATFGPGHGRAGEHPVRQPKGPPLLQELEEKPTSKHEGSKNFATRQRRRAVHDLVRAGRERRSDSGRQLGSGAGTPGSENDFNFSVSSDDSALAGSSTLSSKPSLGSLRAAASGAIGSEIKEKSRERSSVDSVGALSAKSLSSDEGNSVGGPIVEIESARRNTPLLVLSSAEKRKSVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHR4</accession>
    <name>A0A1C1CHR4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03902"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08219"/>
    <dbReference type="OrthoDB" id="4147308at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="748" mass="82101" checksum="0D4B8F4F3CCEB392" modified="2016-11-02" version="1">MLNVPATISFSSIAALIVGSVAIMAWRTHRMSKMHARAKAKDKADDGDDHHHHHDDIAEYEDNGGEGGRMTFNHQGRRWRWKRILHRVGWIRMSFDFDGDGDGDGDGDDRDHDHDHEREMRDMGRRGAVVGEDVPGEDIVYARSIGMEVQSRTRSRPGTETVAAAGVGGVGGVAGGTNKLSRPTDVPCFENLGGYRYGDFAYGPDNMSALPVPVPLPLPLPLPLPLPLPLPLPGPHPFPVPLLEPVSVPVSVSTNISQHQHYRQHSSSQAIAEVEAISVASGTSVSASKRKDPVQARHASSLTSYNGFPSSSQDDIMAALPIPKDHPLSQHHPIGHQCASVLPLRRPRTLFSGDEEEVHRKEQKLEDEDRVLQPKELVVREKGNGSNVQESNVQESNSQESNSQESNSQESNLHEEGRKAPPFQYERESLVPAPLNPRRGRHSPAARRRSSAKASRTWTAQGAQTKVVGRTSPVPASSRPQSCCVSGFGSLAPARSGIRYSHFENPLRQHPVGGDDDLRPMSEIQARSGPHERAALDLPTDEAEEEREAVDPKWPFVSSRRRKRYTFAFDAAQSQDEDAHTSAPPGKGQVEDVDACTSRIDGQDEGDRPCSVQDGGPATKRSNATTIEHSCRSRDELKIAFHTPKDDASLPISFQFGARHATVPPEFLGLEECNSPGLTRQRAAYPPALQIGRSPGALTQQNRHFSVCGRTWTTVRSSSIGRSPEKPMRQTWRAEEIKVGRLKRGHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIT6</accession>
    <name>A0A1C1CIT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04474"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="81" mass="8732" checksum="8139789111A19AB1" modified="2016-11-02" version="1">MATIGTLGPMRSDRVAVALPDTRYRLGARGRLGSTLVADLTATAETWRVRSRMPNTRRQTNHDADSVLGSKMAGDANACDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIT8</accession>
    <name>A0A1C1CIT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RhoGAP domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_03861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIT8"/>
    <dbReference type="STRING" id="86049.A0A1C1CIT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03861"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08508"/>
    <dbReference type="eggNOG" id="KOG2710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04396">
        <property type="entry name" value="RhoGAP_fSAC7_BAG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="80"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="693"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="829" mass="88239" checksum="540A9DE98E79F1B2" modified="2016-11-02" version="1">MATGSAGAATSPQPIVQPLHRAAPGPPPLSTVSPPSRRELASWWKKFRKTTEKNEEKADGGPGIFGVPLADSIRYANVAISLQNDNGESFIYGYVPIVVAKCGVFLKEKATDIEGIFRLSGSAKRIKELQTIFDSPDRYGKGLDWTGYTVHDAANILRRYLNQLPEPIVPLEFYERFRAPLRSATLTPGNNGGTQTRDMSYDDHNIAVAAYQKLITELPPLNRQLLLYLLDLLAVFASKSDLNRMTANNLAAIFQPGILSHPSHDMSPQEYRLSQDVLIFLIENQDNFLIGMSGTAVDEKTQKDVESGAPSVRSPKAIGRSASNASAGAESLRKYGVRRNVSVSSRGSRERGSPGVSSPGTPSGVTSFSGSGGIARSNTVPSKRSPAIAPNRFQRVNDSGDSTTPPAGPVAQENTAPPTTQEPTESKSSRSGSIQPDDADSRAVPAPAPAPAAPVQAPGQPPQPQAQPLAAAPPGPNQTGQAPVTTAAPPPITTRERKISNLFPKSPIFGPSDAQGRQPRKLQKKQKIPGSSNDSAQSSMNSLHGDETATFHTPLVSPDINSVARHDPLAAPQGPAFTNTAATPVNEAPTLKQFPTPTSGADAQNHALKPPSSPPGSTRSRSSFTDHSDGDVVDDALPQPEREKRRHRWRFSSSAKKGENSPLAPPPPIGQNAGARGSNSSLGSSSRPRKSFTGDSQLTQSSIIDPNVSGQQNLVSHSHQESGDPNKDLNGEMEKKGLFGKWKAKISQTREERQAEKDRAKSPPRSEQGASRSSLAAFAQEHFSPRGRSFDASRDQAALSTLTERPAAVEGPAQAAKVSMDPGHRPTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ24</accession>
    <name>A0A1C1CJ24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ24"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04353"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10313"/>
    <dbReference type="eggNOG" id="ENOG502RU97">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4146338at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24378" checksum="6038080815F3C8B4" modified="2016-11-02" version="1">MAAPHLALRVLTAPELWSDAVLVPTCALINESYKGRESEGLLDRYPSAEDFARDLGVDGLCAVIQDSRHENRPVAVAVAKRWTGRRKDDDDDRATALDAGTRDWEIGPAASRSLPEYRGRGLVERCLQGLSARLIAQVNEGPVRLWVKVVEELYAAYWARKGFVQCGASYVIPVGEWHRDRAYTLVDMVKEISRSADGAGDAGSRLEKTGSGIVEPGASELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKB8</accession>
    <name>A0A1C1CKB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11328"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02952"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9676" checksum="32E40DF93A629327" modified="2016-11-02" version="1">MAPSTGSTGYKVLTPDQVSHFMQHGYVVIEQCFSKEASDEWTKDVWTRLGIRPCGHDDVPDFAPKAWDAICDLVGGEDRVTEMSKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKE1</accession>
    <name>A0A1C1CKE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKE1"/>
    <dbReference type="STRING" id="86049.A0A1C1CKE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05038"/>
    <dbReference type="OrthoDB" id="4158189at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="225" mass="23480" checksum="144FFC1B5F80DA2B" modified="2016-11-02" version="1">MCTDSHLPAAPDSAIRVAIIHPLSDPSFHARLSLSNGPGDGTTTTTTLQSADDAAGVSLNVRIQYVFSRLHAAYDMTFFGDGFELELSGQSAVPSPILLALYELSVRKYGAPLSLSPSLSSRSSRSSRTSTGTSFTSGSEPDSDTFDSDSDNDTDADADSSNPIVHSFPVTVSTTTSTTTKNAPRACSGIRLDLGVGGEGVVGRTVSIMDRRSGKILGEGIIGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKG7</accession>
    <name>A0A1C1CKG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">UBI4</name>
        <name evidence="9" type="ORF">CLCR_05059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKG7"/>
    <dbReference type="STRING" id="86049.A0A1C1CKG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05059"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02924"/>
    <dbReference type="eggNOG" id="KOG0001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000004">
        <property type="entry name" value="Polyubiquitin Ubiquitin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT48987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="305" mass="34315" checksum="F42BBF749CA5376D" modified="2016-11-02" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKJ5</accession>
    <name>A0A1C1CKJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04631"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08769"/>
    <dbReference type="OrthoDB" id="4851849at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="727" mass="80783" checksum="1E8F370B45156363" modified="2016-11-02" version="1">MHELGEEIVLLRLLTAEPTMPARNVLVEDSDLRLPTDAGRMLSLANERDIVDNLAFLSATSNEPEKVTAMCLEEGPGSDSCTIRIAMNSNKLSGLVADFDKIARILETADRKAHGDCLNELLDLAVAMNRNRILTRLRSKHAKSSRRIDRCGILTRLGDMVEAVDFVTPLDQATAAKVLDLKFATQRLAEIFSSLETLPVISLTADRIDSLLLRLLESLEDLPASGDLRENLARLPPVSNFQGQEAVVMTIIKLRKYRAASDHIARTARRLSIFRRITVSAVTLSPCKLRPLLHTRPEQRFLDCLERVGLSWNTDTELRLGVSLPHACAQFTKEMTNLQPKVHAEIQLLFHYEINPTTKRPRVICSSKNACFLCELFIRLHGKFFVERTHGVLYPKWTLPDVEKILRPEMRRAIDEVITVFCRHVRAEIREKLANIGRKRMHPSESATSLTQLQPWMQSDESFGRASALSAGGCSRGFSAVATDTGKPDQVQQGCEITKAVGHPGHGDGNEPPIILSGAVTPPRTADNATIEARNRECLGDDDRALCQREGSMSSVTYRSQHCPSLDEEAFLERSELGTASQVRSSIGPECVQRQQTASTMRGHGSRTSNTPAKNDTPDLGNGDDHVVSHLAGVSQKFDFHDLELFLEFPWLSAVIEVARLDSTPPKPYVGSVVDVGSLVPGDELVVDLGEGLKQERILFLTRRDRSGMQSWWKVRWEYVGGRDGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL33</accession>
    <name>A0A1C1CL33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL33"/>
    <dbReference type="STRING" id="86049.A0A1C1CL33"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05253"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02707"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14673" checksum="84A1409768A9D15E" modified="2016-11-02" version="1">MEIIGAAASIATLVEVVKVAVELQQRLQEAPSEIDRTLRHVQFVALQLRTLMEVERSMIEPDDELERSCAAMLRQCHHGMAALRASLGSTVGAKHGKRLRWALLGRARSKELTMELACLDSSLSVVLNILQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL92</accession>
    <name>A0A1C1CL92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular matrix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_05083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL92"/>
    <dbReference type="STRING" id="86049.A0A1C1CL92"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05083"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02662"/>
    <dbReference type="OrthoDB" id="5589325at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650891" evidence="3">
        <location>
            <begin position="20"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="31"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT49276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="238" mass="23691" checksum="3135CE1323DC2376" modified="2016-11-02" version="1">MLSTKFLLLGASLFTYAVAQTKIAFTSVPAVADAGESYNITWGGGDGSPVTITLREGNSNDLKTVATLADGVDGDFFVWTVSKSLPTASDYALQITQGQGSINYSGQFSIVGGSGTSTISATDTSTTTTAANATAPLTTPATIISSGTSTLIASNVTFSSATLSRTTSTSLAPAVTEHMTSSASATSSSFNFGDQPSSTSAAETAAATTSVPDSAGAAQLGSSAALVMGVLAAVMFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLT2</accession>
    <name>A0A1C1CLT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLT2"/>
    <dbReference type="STRING" id="86049.A0A1C1CLT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04941"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03365"/>
    <dbReference type="eggNOG" id="ENOG502SIH3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5413188at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="374" mass="40310" checksum="4459A0B0DFBA7ADD" modified="2016-11-02" version="1">MRPSQPEPFGSHRSERTEARTLRTADSSSLPANASVRGVRSEDSWIEISAGASSASLSSTNNDIITTGLQVRSRDERLSRQLRTSSQLVRPQQRSTSAAGSSQDEYEESESESDRVMSSSNEDIDQNDAAEDDDTSTALGVGSLGRVFTPQPNAFSHPPTSTSHGRPAPDSYFPAVPSEPHADHTVTQRSYQRQMQSRHRPTSSSYQPDHDAALRASLTTLLSCAAAVRPKGPETRPSPPRASTQPTALRLIPGSELQNPARQRRSSSPKQTKRKSRESSKDRLAKKARATSKTATTNEESISPTLASWMISAGVVLVFSAISFSAGYAWGREVGRIEGEMGLPGGNCGQEAMKSSAGGLRRLRWSTAASSIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLV2</accession>
    <name>A0A1C1CLV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Seven transmembrane receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_04947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLV2"/>
    <dbReference type="STRING" id="86049.A0A1C1CLV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04947"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03372"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT49477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="359" mass="40524" checksum="BB2E9C60BD249583" modified="2016-11-02" version="1">MESDSHSNACPAKPAGAGEKGAPLAGSLTFQNLVSIIGWACFAVSTILWLVLVVPHLRQYRVPNEQRQIFKIVSTPLIFAIVAVISTHTYHAADYLEPLANLYEGFALASLFLLYVQYVTPDVTTRDAFFQSLEKKGKKGSVTPGGSLRWFWNTWRTVFFYVVIYTVLVIIQEITKATGAYCSTSSRPRFANIWRWQIQALELGTTIWAILAVIRFQRRLREFMNGKRAVAKLVMFKLFVVITTIQRVSLSLRPVNRNHLTAVQFIFGILRSKVTGGSKVTYDDITIGLPALLNCVEALMFMVGNYFIFNIREYRTGQEKDGPRSRIRKSLPDALNPMDLIRAIGLAFGSLRSRRSSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMD0</accession>
    <name>A0A1C1CMD0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative lactate 2-monooxygenase PB1A11.03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_07170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMD0"/>
    <dbReference type="STRING" id="86049.A0A1C1CMD0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07170"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09901"/>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03332">
        <property type="entry name" value="LMO_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000132">
        <property type="entry name" value="FMN dependent dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037350">
        <property type="entry name" value="LMO_FMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF143">
        <property type="entry name" value="FMN-DEPENDENT ALPHA-HYDROXY ACID DEHYDROGENASE PB1A11.03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="9">
        <location>
            <begin position="47"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="353"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="376"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT49656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="430" mass="46460" checksum="2742B0B054091270" modified="2016-11-02" version="1">MSSHNAVHRPDMAKHTGPGPGPGPNPDSDPDPIAYETEVYQKGLHYEKPPFTFQPLKWEEMAMARMSAESAGYVVGSAGIGETALKNRKAFEKWSIVPRRLVGTERFPDLSVKVLGGQRIPFPVAAAPVGVLRIFNPDGEVAVARACEKCRIPYIMSTASSTSIEEAAKANGDGVRWFQLYWPSRESDSTTISMLNRAKAAGFTALFVTLDTYVLGWRPSDMDNGYNPFLRSDQIGVAVGFSDPGFREQFKDKHGVEVEEDQGKAAAEWTRTIFPGMSHSWDDVKFLQKHWDGPIVLKGIQTAQDALMAAEIGVQGIVVSNHGGRQVDGGVGSLSVLPGIVDAVGDKLEVIFDSGIRTGADIAKAVALGAKMVLVGRPYTYGLVLGGEEGVTHTLRALCGDLDLTLHLAGIKSVSKEHLNRSVLVREDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMK8</accession>
    <name>A0A1C1CMK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMK8"/>
    <dbReference type="STRING" id="86049.A0A1C1CMK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07234"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09962"/>
    <dbReference type="eggNOG" id="ENOG502QS59">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037847">
        <property type="entry name" value="GRAMDC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402:SF1">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="360" mass="41823" checksum="D39D3A2F0E879DE3" modified="2016-11-02" version="1">MPMPDRKLLASSVERLIVDSTPLQTIVMKLRNISHWEDPRESFGYMTLYFFLLFYSYITRALILYILLKVLYRRWHPPTLTKMREATVHSEDQDAIAQNLGELITQYGTRGWVDRVIQEAGPAVFDWLERLADILERTQNFYEWRNPRYTGVTLGFLFTGFVIITLTPTWLLVQMSFLGCGIMFFILTPVGVRYPRYRLLASPITWLLWKSPTHAEWAVSRLQSEAHQYLTSDKTLRTIDRDTHLIGTYTCKDNNDVQGRLVVLVTSVSFAPKRSEHHLNLTSSSRSANKEKDAGEWNLLFDDIKEIHKITEQNSHGGEEAGLEFVPYQGEKRMVMHLARRDEVFSQIVGFSGLHWKRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMZ0</accession>
    <name>A0A1C1CMZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMZ0"/>
    <dbReference type="STRING" id="86049.A0A1C1CMZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06680"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08743"/>
    <dbReference type="eggNOG" id="ENOG502T1M3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3786931at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="817" mass="91223" checksum="483758B8A43138DC" modified="2016-11-02" version="1">MHIQDISQKFVPPLAKLLQFRPNEDPEALSLRMAQGTKSLPSSLRSSRLENFLLPARGHLCSLHKCLHYDVVRSVLRHVQLEVGIRLNNVISHSEMLAPELYSRIKRLRELHALWLDPREYRKTFMASSRDLKWKYQTDGCEACMLSKITSDLQILLDLRWAFRSRATRAFVAKYGNPRLQQWVHVWIATLAGFVEETTGTTIDLDAVILHNDEEAILMKKTRAEIAALRQYTHQYQKSGPANGAYMTQVPYDWSYPIHSAPHQPSPQELPAAQDATGVQAEEFIGDTIESHLEGMDPYEALTSTPYLPRTTYSPPTKQPTESVLTMSTVSADRSSKGRSPYQQRVSERESEVSIRVYLDERLQVVTGDEVDAAHEVAQALQQEYVHPRSTWEKSTPQEPALTSSTLLPRPNATQGPTRPSSVVSTDTWERSTNSSGDSWESEQFVMADCGSSVYSSPPKTPGRNDDKSPSQSWRNPSSVAGERSTSRQRRLVKAQNLDPAQTYTKLLHSSPFSESNATLRQPTQRQQQQQRSRPVQVRCPTKESRSRPASASELFLSLYSEVSRHPASSTLTATNLHNSSVTPSRLVDPGADAHRVPFESRRGQSERSRPAPVAASTPSKPDTPTTPRAPPATQRPKSDSTEQFLKLYDEVVSSYMPSSGQVVGQQPSSTLPQSTSTSVSTVTKNRLTPERLSPRTRPTENFETVDRIVRSTAASGTISNAHDGSRARSITARTTALTPSLVSASTLPSDCSSSPIPPQRGPSCTHSRSSRNREERVKDDSGSDESRQTTWSSAYASQVQDREDLGWYYRERQGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPL1</accession>
    <name>A0A1C1CPL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CLCR_06696</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPL1"/>
    <dbReference type="STRING" id="86049.A0A1C1CPL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06696"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05574"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="386"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT50429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="790" mass="89068" checksum="982B36ED9034F6BB" modified="2016-11-02" version="1">MPSVSSEAVALLTRRATEQTMEDLVKRVNIPINSTTPPALLDAIQQDPFNNAAKYGLIFVYVGIILVVTTTIKRLYYYWGDKIRTALYKEEVINSASTLSPVGFSPHAGFGTYELPSAFSAQTDGSTRHFFPDKGPLVAEKPKQQAAVSAIAPLNNGIAFFRWIFYRPVPSIRIGKYRFTFPSMGVLAVTLVCLVSSILYCFLPTPLFYASMSYGSPPLAIRAGMMSVSLLPWTVVLANKANPIAFLTGIGAERLVVMHRWTAYLCVIFAIIHAVPYWYQSVNDPEGYATFRLYFSQQYWVYTTGITAIVPLLFLALHSVPILRHKAYELFVFLHIPVAWAFIGLMFWHCHNYLTSWAYLYSTVALMLVSLVTRLFFLNWMNPFRSSWLIGEESAVTILPENAVKVTIPTQKRWRPGQYAYLRMPGISPLENHPFTIASLCSEDFPSEYGEQYRDMTLVFRPFSGFTRKVLDTSVKKGPYKTYRAFIEGPYGGMQRQMASFDQVIFFAGGSGITAIASQLLDLIKRMRDGKATTTKVHVIWAMKRPDIMEWFKEELRICRECAPPGSVQCHFFITAARRYDPPGDTKEHRLSGIRDKITDVIDKATSGSKRNSALVMMEQEPDLKREFEDSITALPHAYLAPPRHLAPPSTTAPAHGQLYYPPPPTDKRTSTISQAQIDATRTFDFGFPQTPTKFQKNLMRFAFLPTSVGGSAGLGGHKRDGWRTEYGRPDIPYMLKGLSREFGRRTCVYVCGPPEMRTDVSNCVARLQWDVMTSSGMDEVFLHAENYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPN0</accession>
    <name>A0A1C1CPN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPN0"/>
    <dbReference type="STRING" id="86049.A0A1C1CPN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07524"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05537"/>
    <dbReference type="eggNOG" id="ENOG502REF4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2107174at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051600">
        <property type="entry name" value="Beta-PGM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46193">
        <property type="entry name" value="6-PHOSPHOGLUCONATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46193:SF10">
        <property type="entry name" value="6-PHOSPHOGLUCONATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="262" mass="28991" checksum="46CED3E37177F83F" modified="2016-11-02" version="1">MLTLLQIKYLLFDCDNTLVQSEDVASEICCELINEVLEKRDVAIRFSPEDLITEFVGLNFRRILVTLQRQLGFELSENELKAYNRTQEDRVVANIEAKIQPCPGVTEALARLHESNDFVLAVASSSSLRRIRTCLRVTGLIKYFDDDKIFSAADSLSAPSSKPDPAVYLHALEKLGAQAGQCLTVEDSMSGVGAAVGANLKCLGYVGSTHTLGQRTEMARQLLDAGCVDIMWHWCNYGNHLSTLESQESDELDREKAAQGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQP5</accession>
    <name>A0A1C1CQP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOSC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQP5"/>
    <dbReference type="STRING" id="86049.A0A1C1CQP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08653"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09479"/>
    <dbReference type="eggNOG" id="KOG2362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF23">
        <property type="entry name" value="MOSC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G05900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="239"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="409" mass="46601" checksum="B147182FCD55D6DE" modified="2016-11-02" version="1">MDEAAVIIPPILLAVTLICLQEAWRMRISLEGYNQVTLGGPSNMKDEMDQKYAKPPGSRENADGSRWRVKALYIHPIKSCAAVELGVAELDAAGFTWDRKFAFAELLNPQTRSNATDTGKMPKWTFRTLRQPGWERLALVRPEIWLPDPSRKKLSNDQGWMVVRYPHVPVGPLAPLFRLLIWLGFVSDERSFRVPLVPPPNHKYPSEDVTVWKDSPNWLNYGVHLPKDLGPFLGVSNPITLFRVDPNSYRKVYRCAPRKEQLGYQPVVGFADAYPVHLLNIASVRDIAKRVEKDIPRFSARRFRSNILVDGPGSYDEDDWKRVRIGNHIFYCACRTVRCRLPNVDPDTAERHPVEPDKTLKSFRCIDEGDPLNACLGLQLVPADPDPFQLHAGDEVVVLERGHHKYIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQU1</accession>
    <name>A0A1C1CQU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_08026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQU1"/>
    <dbReference type="STRING" id="86049.A0A1C1CQU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08026"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09501"/>
    <dbReference type="eggNOG" id="KOG2757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="260"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="611"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="615"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="661"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT50855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="753" mass="84753" checksum="4734D4E2ECE6F27B" modified="2016-11-02" version="1">MQHLSHPSAASTAEKEKHYEILLREQGIDPASPTHAPSKTETTSTPEDGDQCDTAVSKPREPVNWAPGSAEGKLIVDQGRSRFIENKLWVTVSEELHHSKDAIPDSETEDELETPAEDGADFVLGMTSSPNQTVNLHPSTDHILRLWQLFLTNVNPLVKIIHQPSMQRVIEDATADLGHIPRGLEALMFSIYAAAIHSMRDGECLATFGEARSILQSRYRLGVRRSLTRAHFMGSSDILVLQALVIYLLAVRQELDARTLWTLAGVASRMAQGMGVHRDGAVLGLPPFETEMRRRLWWQINLLDFKAAELSGFGGFNSMRWWNAKTPSNVNDADMWPGMQEPPVEHVRPTEMVICLLHYEMGGFWRKKLTQAGIAEEDLSRAMTHWVTTKTVAEKDVFVDEFQANLEERILRYCDPSVPLEMMALIIGRMMCKSVRFMAHHPRRYASEKDIPETERHFLWTTSMAILEADNLAHSHRSLQRFQWHIDHGFQWHAFIYVLGELAARPVGEGKDESWAQIEDVHKNHPNFISDRRKPLHLAIGNLCLKAWRAREKAQAESPSGGTLARLDPPQFIIQLRKQWEARAMKSTKLSQPGPSQFNLVPQAKDMKLNEVPNQSHSRSQSQSQPQSESQSQSPVQSHTAAPQQQQQQQSLATSHQQQPHLTNAGSAAFPGTSTGSAFPTTTYSPNDFSVMDDLAMDMDWQRWDTLLNDFEMPVPAAGQPSAAEAMNPAQLEFLGQYGQQGYSWPLPAYRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRG9</accession>
    <name>A0A1C1CRG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deoxyribodipyrimidine photo-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08399</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRG9"/>
    <dbReference type="STRING" id="86049.A0A1C1CRG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08399"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09701"/>
    <dbReference type="eggNOG" id="KOG0133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="48"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="306"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="352"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="450"/>
            <end position="452"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="542" mass="62424" checksum="EE09F3ED1A3B2CB4" modified="2016-11-02" version="1">MSKRDAADHPEQQHPTTKRAKEVDSPETPYQELRSLLGDQQSPKDTKRTLHWFRSKDLRIHDNRALHAASQFAKAANAPLLCAYVNCPAEFRWHGTSPARTDFIMENLGLMKAELQKLDIPLVFLEASERGKIVPTIVDFVHENGISHVFANYEYEIDELRRDIQVLKVASDGNVKSKGFHLSMHHDQTVMEPGTMLTDAGKAMKVFTPYHKAWLAEVKADPSLIDTVAAPVRNIPKAKKALEAFFDSPVPKPPEEKQFSSKEERDRIRQLWPAGHKAATARLTHFLDDKIADYAATRSQPAKDSTSRMSAYLSAGVISVREILTAVCKRNNGTTDFSQSGCDKGMAGWVRELVFRELYRQTTVQTPHTSMNMPQNLKFDFVNWEDDEEGYQRWEDGTLGVPFVDAGMRQIKHEAYMHNRLRMNVSSYLYCNLLIDYRRGERYFAETLIDWDLSNNTQGWEPSYTVFNPVSQAEKNDPEGEYIRKWIPELRDVKGKAIYDPYHRLDKDEFEKLGYPPPYVDWKETKQRCIERFKSDMRDAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRV8</accession>
    <name>A0A1C1CRV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09349"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="90" mass="9916" checksum="61EFD3959C0A5F06" modified="2016-11-02" version="1">METVTVRVVVEVIVVVWLVIVSVDVALGEDELERELVVASVVMVEEELDAEEVEVESVVDTDVLELDVVDELDDPVLLLALLLLIRCLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSH4</accession>
    <name>A0A1C1CSH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSH4"/>
    <dbReference type="STRING" id="86049.A0A1C1CSH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08720"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06643"/>
    <dbReference type="eggNOG" id="ENOG502QUAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF3">
        <property type="entry name" value="(3R)-3-[(CARBOXYMETHYL)AMINO]FATTY ACID OXYGENASE_DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="14"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="340" mass="38850" checksum="EEC43B56BD91FBB3" modified="2016-11-02" version="1">MPHATNTEYHHIQLKKLAPTFAAEVTGVDFSKPVEKEVFDEVHRAIVDYGVLVFRNAGLDDAHHVAFAALFGELDDVKPYLAMGRKNRFPFDELFDVSNQEDDGSLVKLGSKRHHMGLGNSIFHVDSSFNPRRAGYSLLRAHQLPPRGHGGNTDFADTRTAFDELPEDLRNDLLENEYIGAHSLMHSRRKAAPKDSEWLRDIDPEKFPFGRHDVVQTHRPSGRPNLYIANHMHHLEYKKARSPSFTPTKEQPFERVPEPKGTELIERLLAHASQPRYVVSVEWENEGDLIVWDNTCVMHKAGEGTFMEKYARDMRRCTVHDGSIDAWGHNERTTKRMGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT06</accession>
    <name>A0A1C1CT06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT06"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09300"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="115" mass="12462" checksum="C040A978F20AD812" modified="2016-11-02" version="1">MTTVLNAGITPEVGNDRDAQVAADVALRHRTPSGVAADRGDDWPPWTILRSTPQSEGLEVGNLPDMLPFLLCDRQNAMKRMRNPPTELARPVLFTTKSDVAGHMGKGTSSTSHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT93</accession>
    <name>A0A1C1CT93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT93"/>
    <dbReference type="STRING" id="86049.A0A1C1CT93"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09038"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06388"/>
    <dbReference type="eggNOG" id="ENOG502TBQK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651033" evidence="2">
        <location>
            <begin position="23"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="246" mass="26630" checksum="721B6EE10265D551" modified="2016-11-02" version="1">MAGRKCLLTLLVLYACTVLAAAADAAASKLPNSVTLSYEVIGSSSLKPLATVFYDPRTSKHTLSSWTPPDLDSLQSTTPEPTSSKLLRILLPNGSSTITTLDTFSDSVYKKIDLWISPDDGSVYSASVSSLSPPPLTPEEEHYQKKVARAKAKGRPIPPPPPIPKTKKAREEAAARAAMHEPIRVNLLTSSPGPSPVLATRAPPQVDAEGREVPQEEQQEKSFFQKYWWVFLIATMLMITSGGGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTF8</accession>
    <name>A0A1C1CTF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_09090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTF8"/>
    <dbReference type="STRING" id="86049.A0A1C1CTF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09090"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19877" checksum="4793AD4200A31447" modified="2016-11-02" version="1">MLTCHEADQRVDVFNKEMAYFGEPSEATDAAWAHLIPGGRGIISQRWPDGTRKYKVISAFHQMHCLYVLRTLYFTQRSGQTTNHEHFSHCVEYLRQSLICFADRTFETLDLSDPDSAAWGEGHLCQDWNQLFNWAFKHREFDEGGIENDTVLGLPERVWQELKGREHRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTH3</accession>
    <name>A0A1C1CTH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTH3"/>
    <dbReference type="STRING" id="86049.A0A1C1CTH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08390"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06313"/>
    <dbReference type="OrthoDB" id="4135186at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="261"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="522" mass="58897" checksum="D4506AC49F443DF2" modified="2016-11-02" version="1">MSMRSVRFDMNQLARVAADALAADRCVSIEKCPDGMYNKSYLFTMSDGRQVIGKVPNPNAGIPHFTTASEVATMDFVRAIKLHSIFGFADGLGGGPHRLRNSSTSADNPVGAEYIIMEKMPGVQLLQVWDQMALTDKLQVITQLFKFQRMWLSARFGKIGSLYYADDVEASAPDESHLFTDTNGTEVRNERFAIGPTTGRDWIDEGRSLLKCDRGPWTSISDYYQAVLQREIDATKTARRLPKQMVMLCAPTLYLPTREKKLAVLESYAHVVRCLLPSDPLVCASHLWHSDLHDENIFVDPVNPTRIIGIIDWQSTQAGPLFENTIDPGILDYDGPDIESLEKPTLPQKYKELIEADKAAEIKLYYSKSLLVAYRRLIQKNPSLKRTSEFQASTAFAILKLSRRIFEVGKAHVQALMSGLRLEWSDLTAVQQAGEPGFPLSLSVSELQRIESDAEAADAGIQAMDEIRRRLGRYWPEKGAVQAQHYDETKRLLKQIKEELLHEFAVDPEGMKVFEQFWPFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTT8</accession>
    <name>A0A1C1CTT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09374"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="75" mass="8374" checksum="00A62D264F4488FD" modified="2016-11-02" version="1">MYNNFTTASFPAERSKQRTSTISIPQPTNQERLYIHRTAPREGIGRGGEGQEAEKRSSAKEEGASRSRNSHLLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTX2</accession>
    <name>A0A1C1CTX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_09036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTX2"/>
    <dbReference type="STRING" id="86049.A0A1C1CTX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09036"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06172"/>
    <dbReference type="eggNOG" id="ENOG502STK7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="45"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="205" mass="22399" checksum="975CE47C707F9AAE" modified="2016-11-02" version="1">MPRFGRFGGRRGSPSATGAPTSDYGSPARRSNPALRPAILANHWLHWISSIIVLGISAYFIAHYNHNTHLVYWVTIAAIDALIYLPALFLPALGSYKGYLAPAAWIFSYLWLTAFIFSAQDYNFNAFGCPRSPSGVNKCGLKKTLEAFAFLAFFTNIVGQILEGWLWAKQPFKNRRRNAGVEKHGVGSTSTGATTVPPTTGTTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTX5</accession>
    <name>A0A1C1CTX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endo-1,5-alpha-L-arabinanase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_08484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTX5"/>
    <dbReference type="STRING" id="86049.A0A1C1CTX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08484"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06170"/>
    <dbReference type="eggNOG" id="ENOG502RK68">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3879658at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08999">
        <property type="entry name" value="GH43_ABN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="6">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT51958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="447" mass="48977" checksum="C445B0A7A5AB4887" modified="2016-11-02" version="1">MVVMLWRHLSTLIANQPRAALVKGSALILLFLIIVSTVTVVKYSASNVLTTTSTIPTAEYAVINSNFADPCLLSVDGMFYAFATRPDPSLHVQVASAKDISDWTLHEGYDALPILPRWALQEGDAAVWAPQVVQRPDGSFVLYFSASWNADSRFHCVGAATSPNVTGPYTPAEEPLTCPFSQGGAIDPTFIHDPRKNMSFVVYKNDGNAIGAGGACGNGNWPNTPTSFQFNIVDNEDYTTRIGNDTWTPVGNASWVLFSDRSDGPNIESPQIFYRGDAMGRFAAAGDDSAYHLIYNAGCYADESYRIEHIVCRATQLNAVSTHWTTHDPTYVPFFRDCNFGAMKPETYTSWGQSFLGLKDSIDNHYDLLLKSGTFRQPDGSAVELYAPGGPAVTQDGAYMAFHADISRDWYEGKVCSGCRIRAMFIAELEYGNKGTGLKVKRLIKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU55</accession>
    <name>A0A1C1CU55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative actin-interacting protein (Bud6/Aip3)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_07918</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU55"/>
    <dbReference type="STRING" id="86049.A0A1C1CU55"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07918"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06116"/>
    <dbReference type="eggNOG" id="ENOG502QS95">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="4">
        <location>
            <begin position="551"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="498"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="887"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="975"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="704"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="975"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1011"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1026"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1089"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1110"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1137"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT52014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1149" mass="125485" checksum="A36D8A897DE8054A" modified="2016-11-02" version="1">MQASSAEGGAQRPSHSQRRQQDLSGSAYPQDQMMAAAMNPSTSSASHQARSSSGSGRSQRSANPDKQISQIEKSVTHLLVATKQLLETLTQWSRGQAQEEEVSDVYVRLGYEFNLACRAFNSIGVETADLGPVPDLLRNILEDTLSQPASPQALDNYLPRIRDIIINLLHGLKRKQSRLRGRATKDGSSTPQPRPAAGGGRQGSVSTTGSNETGLTHMLDDVPSSTSSMRAQSPPGASTASDQLYAPANASAVTPANRPTLNRHSMRRDVPLPLPQSDSSSTISSSATPQNVPAPSFPPGHDADGSPSVTQINFPHPPPPPPKETDALTRLQRGGDLERRASRRFSAYQIQKHLGASPNGVPVIPTAQNSPIPNRGKEVRESLSAVRSRSSYQQSRSKSVRQGDISPSRSGTVRAPQRISEEREETPVLSLQDVPPMQRPEEPTNLDSPTVKTPDEYFKAPRIDTRGGDALVGATVNGPLSPPPEELQETVSLDSVLAPAPPAEHTTPVETDPVKTPDTAQRRPRDDVTPHQSQVLASDSSPQQGKELTLFLQYRSKIKKFVLADGYEELTIARLQLAFIEKFAWNTQHDGAELPEIYVQDPVSGVRHELEDLSDVKDRCVLVLNVEALDEVKKHIDEGIGGLQKTLDGVRSLLEGQGTLMQRFSDRQLETSKEMARMSAIPAQHPTRTPTLAQGKFTPSAAASASTLQEIQSLRQEIAVLRQTYSTMTSDFSAAMSDIKAKAANVKAVAAEAANASYKGDAGRAHINEGKKTLSDDSEALVNRVDDLSDIVEELRKDVVSRGVRPLPRALEDISKEISAAAKQLAKVKDFVKREKPIWTKIWEQELQIVMTERDDLTQQDELLNDLDGDLDDITNVFKLVEEATKQQNIQTGGGGRQPSRSLAFDTDVDPHEAKSGMLDEVRALQPNHESRLEAIERAEKIRQKELESRKVGEFQREVETFVEEGKLRKTGGMDEVERRRKLKDEQARRDNYERQQARAAELERKRAEEAAAAAAAAAAAASAETNGASPQEGISEQDPQTAFEDGKDERVQPCDGETFAAPSVPPKDGTREAAEAAAKVDLPEIEIEAGHEGERGLDTAVPSSTRNTEPGDHHEGEKERPDRNDDAEKKKEDNRASGNWWQPAIFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUE4</accession>
    <name>A0A1C1CUE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ARF</name>
        <name evidence="17" type="ORF">CLCR_09010</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="16">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUE4"/>
    <dbReference type="STRING" id="86049.A0A1C1CUE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09010"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06028"/>
    <dbReference type="eggNOG" id="KOG0070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT52115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="180" mass="20562" checksum="AA9E797F05E395A5" modified="2016-11-02" version="1">MGLTFSKLFDRLWGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNIQFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRDRIVEAREELQRMLNEDELRDALLLVFANKQDLPNAMNAAEITDKLGLHSLRQRAWSTCATSGDGLYEGLEWLSNSLRKAGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUF5</accession>
    <name>A0A1C1CUF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08937"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06011"/>
    <dbReference type="OrthoDB" id="10688042at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651121" evidence="2">
        <location>
            <begin position="21"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="290" mass="32264" checksum="3EB73931512B88AB" modified="2016-11-02" version="1">MQLLNAIIALVAAFSAHVQQQTTDLVVAFRERALQPVFHNFLAIEPSIVTSTVTSTITAAPTASFTTTVYHGGSIAVVATSPPPTPPSTAVPHVQYCLAPLAWANWEEPSFCVSERAFELLSAFLTTLSEAPTLHIPQSILARLSSLFSLHWERIRIATSLIQQQTLETMSVVVNHATSIVWKFRVTASAVSCSMGDFLASLTLPQWLIYCFQFVTTGFLLIGASITIVRAELRRQDVLQRKQREEMKSTRARHRKVIAEALDYYEQGKITTASTKEEARELLVRYWLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUT6</accession>
    <name>A0A1C1CUT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Obg-like ATPase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">OLA1</name>
        <name evidence="5" type="ORF">CLCR_08479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUT6"/>
    <dbReference type="STRING" id="86049.A0A1C1CUT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08479"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05910"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="21"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="363"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT52253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="451" mass="50123" checksum="7497B722276D0CAF" modified="2016-11-02" version="1">MPPKKAAEEKKILLGRPGNNLKSGIVGLANVGKSTLFQAITKCSLGNPANFPYATIDPEEARVIVPDARYDWLCEHYKPKSQVPANLTVYDIAGLTRGSSTGAGLGNAFLSHIRAVDAIFQVVRCFDDAEIIHVEGDVNPTRDLDIISEELRLKDIEFVEKAKENLSKQTRRGGQSLEMKKLKEEEATVDKILQLLKDGKDVRKADWGPKEVSSPAISYLPLHDEQELYARHNPSSSTAASPNFTFEAVMRGSPTLNRPRRPIPCTLFLIEVINPLFLLTAKPVVYLINLSEKDYIRQKNKYLPKVMEWIKTNSPGDPVIPISISFEERIAVMSDEEAAEECKKLNTKSALPKVIVTMRQALNLASFFTTGTDEVRQWTIRKGTKAPQAAGVIHTDFEKTFIQCIVYNYETLREYGDENATRAAGKVMTKGKDYVVEDGDIILIKAGAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV29</accession>
    <name>A0A1C1CV29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV29"/>
    <dbReference type="STRING" id="86049.A0A1C1CV29"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08300"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05839"/>
    <dbReference type="eggNOG" id="ENOG502RY95">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3248508at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="49"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="445"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="592" mass="66117" checksum="15B343F199647733" modified="2016-11-02" version="1">MNHLSPTLSPNLNPSTYPYSGGLHDSRASSTQSLRPVESPGDNRRTLLIIYIHGFLGTETSFQSFPTHVHARLTAALAETHVVYTKIYPRYKSRKNISFARDDFSNWLRPHESSRTDIILVGHSLGGILAAEVALIPSSSPVGSNELFQHRILGLVAFDTPFLGMHPGVVGTGIASLFRTPLQPSVSPPADPDMFSDAAPQGPTYNPRYANDIRLADRTGKLRRFWYFWNKHCGELAKATGDYVSSHLEFGGCLADYPGLKRRFNAVRALEDVDETAKPRTPDGKLMKRVRFVNYYSASTGPVKERSPSPSTRSGLLEPPTNELQETSTRRSSAGSLQPSTASSPRLSLEEHRDGELITKDITELNIDPDPPELTPATTVNEQVESSSATDASVSLLEPGSAELGLLPPIPPLPAPPPEFDAGLFKEEDIVKLLRNEHDRKVRAYERAVKDREESLKERQKLVERRQRNMVKREEMAKKQAQVQQARAQKEQKKRAATLNPEHYDKQLQAETARKQKDRKFCALPPKDPASGKRDDRWIRIYFEGIDEVTAHTSMFNVSDTYAKMVADVVERIETWVAEDASTRMILAEMGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW16</accession>
    <name>A0A1C1CW16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW16"/>
    <dbReference type="STRING" id="86049.A0A1C1CW16"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09605"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04068"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05168"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07951"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF11">
        <property type="entry name" value="HET-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="25"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="817" mass="93226" checksum="38D5933C016B8166" modified="2016-11-02" version="1">MRLLKIDRLGNLSLTEDLQDNLPAYAILSHTWGDDKDEVKFDDLRSESWKNKAAAAKIRFCSEQAKKDNLTHFWVDTCCINKANSTEYSEAINSMFRWYRNADKCYVYLVDVSSHGEDGHYRQTWQQDFRESRWFRRGWTLQELLAPTSVEFFSREEQRLGDKKALEHLIHEITDIPTAALRGAALSQFGVDDRLRWAENRDTKKQEDKAYCLLGIFGVFIPLIYGEGEYAFTRLKEEINKSLGGSGPASGNVHWVVPRSPNTLFTGRRDMLDMLERTVRAAVQHGWDSNQCRVVIAGLGGQGKSEISLQLAQRVRPLLWGVFWVDVSTPSLAETGFLDIARRLRVPVSTWEDGRQALANITRPWMLVLDNADDPNVNFQAYFRPGSFGVVVLTSRNAECEQYATAAYVALEGLPPDDAKELLLRAAGVASSQRVLEDDARGVAILLQSHALALIQAGAYIRRGHCTVADYPREYERQRKRLLGFRLSQGQPRYPDVYATFEAAVEILQASQTQSARDALEVLPLLAVCGPNQLPLLVFEAAWNGAQSIRTDETADEGNFPLTMWHVSRLPSLMHVSCDVWDSFRLVEAVNALREFALVSTNVEHGRMSVSMHPLVHAWARDRQDEQQQHESWICMGCVVAVSAIEAVMRRVNTRQLQPHLQAITSWEMGCAFQSEPPVMVTTILMKCGWLLERMRDDKTLFMLLDRLCSYLKLDKFRVDEDWLRLYFLIGRNLLEYGRVRDAANLLEEVARLLTKRFPEDHIVRLMSQHELARAYKANGQTEKALKLLEEVVRIQQTLPEDHTWRLASEHELALSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW94</accession>
    <name>A0A1C1CW94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW94"/>
    <dbReference type="STRING" id="86049.A0A1C1CW94"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09503"/>
    <dbReference type="OrthoDB" id="4227485at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022198">
        <property type="entry name" value="DUF3723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12520">
        <property type="entry name" value="DUF3723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1049" mass="118809" checksum="EC9AAFF27A2D6028" modified="2016-11-02" version="1">MEDQNPWRKAYIGSARVRCASLVHAESPEASLDSAKLKRLINIFALSGCQRLDENHRIRVLLTEDEHRKLTHIISPQSLSEPALPLIDLGDGRLTYLHGRHRLAACQSVMPPWDQWWGVDFYLRSKISNRLQIEHLVHFDNTQPYNDGVIFREICAWSRDNSERRKLWLSRLAPNPSKLRDLQQLLRQPRQSSLLEAFVSLFPLDGLWQDFRIGTFHRILTMHCTEELTHYLRHLRQTWIHLLGGASTDAYVDAATVRSLQGRSPRYSLSDRAHIKQSIDDRKAFCWITDEDQRRGVLERCCKLEHTIPSIRTFLEDTKWLEPGSKIVRRLFPLKSSNSIRRTLNACYAGPEAQHGQGFAESYRALWLYALKYFPELDSLRPRQESRKSSTLQLRSSGEAWGEFIRLAGSLHFQAPVTNLADLQQTTERAAANRAPPLTVPIQLHPKLAIPFHQDFDIKHRCGRVFELAYKANQVNLSLENIYRTFTDADAGSHITPFAISRDTFRAFFGFQRHCTLEVLVDPEDYILPSLQNNEVYHGTQIPTEPSQSQSNNEPGEDQEMADQEQHLQSREAPPPPTTQTTQFQYLGAFQNTSMHQGPAETDNQFREDPSRGQEMANQVQQLQPCEAPLPPVTETTQFQEFGAFQSTSTSDPPAETDTLSRDDPGDHQEMVNQVEQLQSYEAPPPLASGISQRPPTEVETPHGVISQVASGMSQPARQDDSSIIGRTEASEDVLPESLSYVDSDEQRIGLAGSYYHQNDTDNLFEGENSDDESQELSAHTKKGRLIITDQTKTMQQTVIAEKVRSVEQMTAVATSAQSTITEQPAVAARPAAAGLRTQTRIGTKRSSILIDKSSHPKAPRRDVRSETPLQMLIVGLHAVYVQSKKDLGIENILIENLGRTRMDEDYRVYFYGRCDIAFDSVKHHVASLIRQGRQIYQVTVKVLGAGEWLTLSPLLQIDSARLFTVYYAHAPGLPLTVTGLLPSKQSTRGALDFEVFPWDEELGEWKLDPEVGREWARKVRARERKRSSTQTTAAPSPPIPSDTEESEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWD4</accession>
    <name>A0A1C1CWD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWD4"/>
    <dbReference type="STRING" id="86049.A0A1C1CWD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10545"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04099"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="281" mass="30102" checksum="DA5AB3E49CE61E04" modified="2016-11-02" version="1">MGLVTTYFKKNRGLAVAIVSSGNSVGGAVYPVIVRQLLPKIGFAWTIRVVGFVNVVLLGLCLAFLRPRLPPRKSGPLVEWKAFTEAPYVCVLLGMSFVFGGLFFSYYYLASFGRDILHMSYSDSLTLLIIFNGAGVPVRLATGYIADRFLGPLNAMVPLLFINALFAFCWIAVRSQAGMYVFATFYGFSAGAFQCLMPTVVTSLNNDLQRNGIRMGMAFSLFSFAGLAGPPIGGALLTTNGGGRGGYLVAQLCLGVLTAVGASLMCAARVYKAGWSLKVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX13</accession>
    <name>A0A1C1CX13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX13"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09663"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04402"/>
    <dbReference type="OrthoDB" id="4152703at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="777" mass="86759" checksum="8A05BD72B5488809" modified="2016-11-02" version="1">MQALQTSVQRGLGLVSSTLTAPRGHDQRSCLSENVSLSEESVRSANTQRLRPTTWDSVSQISTVAGNTSSSDSPAFLYLRSASYPTPATEPSPTDPSKLKKLGPLHEHLETIRKYTPGQVARDIWTASALKFGDGGVVTNDNVDAGEHNNSWTFWEKMVNTADALGTARYLNNAFDLHYLCFVEIFTDTGRRLSHWETTPEDAGQLDQDQKASKVMASTPLLLQLLTRAVIGAARSCTTSADSKLARVMLDAAHCVFRQLKYATRVRALLILFDVYRNTLIDLWHGQNTPDTPKPLDRDSALPVSPKSTRLDQEYSLDDLVWSIHPAILNREYFVVSTHLLNLSRYHQSWLSLPARSTAWEKPLAEFVRNLAIPSKSSQAWVRLLQEHEPPEPPDFLDAYIKEAKAFLQWCTNAVFEGQTILNGAFTDQPPSSHVVSRDSLNDARLTLYWFFVSRRKALEIQPSRPSPSVATSLPMFPHSDNAHTTLDAFWVLSSFIFGFCSPEALPTSLRSLSDYTLTKLNHMVKWPYGFVWRYLQQTICHASKLHVDGDFVQQEDIRQKYIDLAILSAEQRSKADDDPVVQVAVELHPQPLPEFIDAADLHSHNRSSRKVLFTTSPDSYHFPLKLPVKLPVRLPKRRWLQRLSLTGISVSSIQSPSLSRPSMSRSRTEPTAFSTPTNAKAHRRSVDSWNLMAAAAAASNTYKVEEFSGDYSAIVPDLLYTTSGIEESSRREIHATAATDGGAIPAWRSGADKVGSVVQSTEIVLPEARRPFVVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX32</accession>
    <name>A0A1C1CX32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isopenicillin N epimerase component 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cefD2</name>
        <name evidence="2" type="ORF">CLCR_10399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX32"/>
    <dbReference type="STRING" id="86049.A0A1C1CX32"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10399"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00106"/>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="374" mass="41421" checksum="33E13D8CF7927211" modified="2016-11-02" version="1">MSSAPPLAGLKVLELGGLAPSPFAGLILADYGADVVRVDRTFEVFGPPRDTLCRRKRSVVIDFKDAPSRQVFLELVQIADVLIDPYRPGVMTRLGLGPETLCQLNPRLIYAHLHGFRPEGVYGRRAGHDINYLAAAGILSILGRKDENPAPPANILGDFAGGGLVCVTGILFALLHRQATGRGQVVTANMVDGSAYLATFMRQQQGHPNNDRPRGENLLDGAAPFYEVYKTRDGRFVAVGAQEPQFYRSLLQGMGLDEKEMPEQWDRVHWPRTKELFTKVFKQKTMDEWRAVFDHTDGCVTPVWNMDETERPFKPLVDLSASPSLDVSVQESYPELKKGAGAEDVLQEWIPKSKSSVDIDPSSKLLRMKHAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX61</accession>
    <name>A0A1C1CX61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase G7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_11098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX61"/>
    <dbReference type="STRING" id="86049.A0A1C1CX61"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11098"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF11">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="82" mass="8858" checksum="BDE1AB66B4CB12FA" modified="2016-11-02" version="1">MPVMDGMTATRLIRQYESQNSLPRVPIFALTGLASAAARNEALESGIDRLLTKPVPFDALAEILLLSQAPSTTHDKGHGRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXX4</accession>
    <name>A0A1C1CXX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase CipA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXX4"/>
    <dbReference type="STRING" id="86049.A0A1C1CXX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10605"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00363"/>
    <dbReference type="eggNOG" id="ENOG502S12R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="303" mass="32163" checksum="A6D773B8F008F428" modified="2016-11-02" version="1">MASTTKVALAGATGNIGVPTLKALLAANHDVVVLTRKGSNSASKLPQASNLTVKEVDYKSVDELTSALQGVKVVVSTLATASIGEQNPLIDAAVAAGVERFLPSEFGSDTVNPVTSKLPVFKYKVETQEYLKEKAAQNPSFSYTLVITGPFFDWGLEHGFILNPKGHSGTLWNGGDVNFSTTTLASIGQAVVGVVAHLDETKNRAVYVHDAVTTQNKLIAYAKEKDGKEWDTSVKSTKDVYDESLKELQSGGDIGKAMVGFILSGIFGGKETGGTFEGRDDNKLLGLKGYSENEVKALVQSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYA5</accession>
    <name>A0A1C1CYA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">swf1</name>
        <name evidence="13" type="ORF">CLCR_10157</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYA5"/>
    <dbReference type="STRING" id="86049.A0A1C1CYA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10157"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00423"/>
    <dbReference type="eggNOG" id="KOG1312">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF480">
        <property type="entry name" value="PALMITOYLTRANSFERASE SWF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="153"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="365"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT53456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="433" mass="50035" checksum="16A95FF2850923CC" modified="2016-11-02" version="1">MGLVRSIAIVVLSISLIVFVALFGRLPAFRRTPIAFLHRLLWVYIPHALGQVDERLTGRRITRSLARTGDYLMNEKHPLVLIFFVGLQLIGEILFIPAAWDRLSFAQIAALPPLIIAPLWFLYLCNTTDSNITAQNHRSAMLAYPYDYALFHPGYFCSTCRFAKPPRSKHCSICKACVQKQDHHCIWINNCVGRANYLWFNALLVSIAALLVYGSHLGYGLLDARLQDRLVPPALTRGSLTSKRWSTRLSWNEYAHAWAWAIAVEWRIGAVVMLSLMCVPLAFGFLAYHLYLIWAGMTTNESSKWSDWKEDIRDGVVFRAEMQALRETFPPLPEDVQPRDEDVKWPRGVRARWWLVRTRDGERPKRRKLKRDGSREGRRHIPGKNMDERDDLEQEQEEVPDDRWEKVTSIAQVENIYDLGFWDNLLDGLFNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYF1</accession>
    <name>A0A1C1CYF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11099"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="82" mass="8767" checksum="729C28E4A82A7E7C" modified="2016-11-02" version="1">MPLQSAPLDATSRNPTMAGSTDDGYGHAAEAEAFENDTDSRCRQIRDGKEISATRNTRAFCRYESDSCKITATAASSDSLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ15</accession>
    <name>A0A1C1CZ15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn2/Cys6 DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_09902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ15"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ15"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09902"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00704"/>
    <dbReference type="eggNOG" id="ENOG502SJFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="190"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="604" mass="65646" checksum="8B32C9BA7DE20595" modified="2016-11-02" version="1">MLPSSHSLADGHHLSQIEGFASFSHTWEDFASEPFDGDIFESLELAEDESPTSQNPIEHVQTRSDGRPVSNSPQHSRLQSLHPFPGKPLSLDTGSLRRAQVPPDTSHLNRHVMLSLMNRRDHLEVSHIRLERARPANEAHAPDEVVPVLMVREHAPFLPNGAAASTSQPATPWQDVEELLSEKQRHELVQLFFHFVQPAFPVLSGAAGAKADSDSHGHDECDLSTASLSLSACIYATALPFSIHNDYLNATLTDANGKREQLYSMAVAAVLAEANAPTLETLQACLLLLQKGPTVQHQGLTPTYSAFASMTVTIAKSLGLQHDCTNWSIPLAEKQLRQRLWWATFIMDVWVSIDTPGGRSIGSDDYDVPLLAGGDVANIDHRPDMPEYTHFNCLVDTSHLLSQICRTYYTVRAAKETASDLFKSLEFAKPLRSALNECKQKLKVIMPLDGSGEPGASGSVHLAACVTSIILFRALLRPIQAGISTAPLLGDGHMSAAAAVVTGSINCAREAVELLETMVSMVGPWSEFWHSWSQGNFAIVSTFLVQLMVMLMSSSEESTKAEVADLISRWKKAIRVGAGSGGWGSSLMSMALSRLDSLLSHAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZH9</accession>
    <name>A0A1C1CZH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZH9"/>
    <dbReference type="STRING" id="86049.A0A1C1CZH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10208"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00690"/>
    <dbReference type="eggNOG" id="ENOG502QVCU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="457" mass="50545" checksum="4A44B19B5A9F7D27" modified="2016-11-02" version="1">MPLPHPKPMPSYWLSYDSNLQNHRTTEALPPEADVVVIGAGYTGAATAYHILEKSSSKRPSVVILEARCICSGATARNGGHIKPDVYFNAVLSEKMFGPQMAQQLTRFEMQQVFDVKRLVEKEQIDCDFELTRAIDVFVDPRVAKQTIAAFEEMKASGYRFADDLHFIQDPKKAEQVSGVKGALAAFTFTAGTVWPYKLVCHLLRRCLEWGANLQANTPVTKIAETADDRGRWTVTTPRGAVRAKKVVFATNAYLSTILPEFQDKITPARGVACRIAVAANSKKPAPHLNNSYSIRYGPQEYDYLISRTDGSVVVGGAKQAVLLDETYWHNNINDSELIPGAEKYFTGYMQRMFHGWEDSGAEITDIWTGVMGYSSDLVPWVGDVPGRPGIFVNAGFTGHGMPRILGCSEALAAVVRGDVHSLKDTSLPAPYWITEDRLRAKESVTREYMAGSRPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZN4</accession>
    <name>A0A1C1CZN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10949"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="154" mass="16875" checksum="8CBA98131136EB66" modified="2016-11-02" version="1">MGSESGGEIVVVQTVITIAIDRIGKGRNSDEYSVPLTVSLYDVRVGTSYPCYEDAPVDRHAMPHPGIRETCEMRGADLLRGSQRFGTNKLGVAGDTVHCHLHPNPGTHSRHITSVSTFQFACRTNPPSFSGSQTGGYNVDFARYRELKVTKQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZR8</accession>
    <name>A0A1C1CZR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10893"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00956"/>
    <dbReference type="OrthoDB" id="2772415at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="127" mass="14546" checksum="6497E07B25BB8B06" modified="2016-11-02" version="1">MSHPKPYKVITVSTTPDRASRMVRRLAEDVKDRYMIIHCVNVSKIEDVESRVTLYRPDILTRRQFCASTWSPDQSAEIKRIARGIVPGLRCYVIPPRMQVEKDSVATIEHIKAQLPMIIEGNLGLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZU0</accession>
    <name>A0A1C1CZU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Camp independent regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIT1/WOR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10239"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00807"/>
    <dbReference type="eggNOG" id="KOG4476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5319641at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="447" mass="49903" checksum="9A2E6973B1E09396" modified="2016-11-02" version="1">MSSGGAALQPTFQGHVSTTQDALILFEACLQGHLSHVPRRPHDRERSSLIRSGCVFIYEENASGIKRWTDGVTWSPSRILGNFLVYRELDRPFPPGEKKRAMKKQQRRPSRPGEPYARSSETGSYADGQSTGYSQDRTTSAEVERQLIGSLVDSYGFKQDGLVKKTMSVTVQGVTHHLVSYYHVNDVLNTQLRRPSETESLTYVRPRLELTQKQSFRAPLEEQNEVDATQSAYGYRVNGAAYPQTSFYMPPSYPSVAQQPSQSPYPMGVPAISTAYMHSSITAPHLQGPRNDYGPYDQAGYNRSYESLNGAMTPTSKSIPPTPTTMAPMIADRAQPQPPMYPPMSMQRPVNSLSPVSVDTHNTVPYRPSPYPVHHSAPAQLDQSRQSQHSPVHVKYEDRRDQAPPQSQMYQSTRTGFYGETAGQVMHQPQYSQQPPIPQWVGQGHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D073</accession>
    <name>A0A1C1D073_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_00168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D073"/>
    <dbReference type="STRING" id="86049.A0A1C1D073"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00168"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02537"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427213at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="414"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="554" mass="59698" checksum="298D97642E78B6D6" modified="2016-11-02" version="1">MSFLRGQRWSGGPTTHLPRYFPFLRWIREYRWEWFTGDLIGSLTVASLYVPLSVSFALLGHAHPISGLYSFVINPLLYALLGTCSLMVVGPEAPGSLLVGTVVTASSSGSSDDENNLISAQIAGTVTACTGALLFVTGLSRFGYVDSVLSRPLMRGVIGALGLNVLIEQTVTGLGLGTLAREDSHAAGGSPAQKLLFIVTNHVEISSLVITSFLVALVGLFESSLTAKSLRKASEGKGGINLPANADQELIALGVSNIIGGSFLALPAFGGYGRSKLNFSTGGRTPMSNVLLSIMTLFCILFLLPAFYYLPRGVLAAMIAVVGVSMVEECPHEILFFAKIRAWPELALMAVVSAATVFHSVSLGMALGLGWSILSLFIIGGWRTTIRILDSVSSEVPADPEFAQMATLCPMRTIFVTVSGPLTFVNTNNLKERIDARRHADPPESRVHRSDSWPAATGETALIFDMRHCTRFDGCAIQALAEIAEEYTVEESDRIIIWEPLQLHGMDPIQHKLAQSGTLNLCGENISFVTSLGDILMILRAERRPESLFESMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0D6</accession>
    <name>A0A1C1D0D6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_00261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0D6"/>
    <dbReference type="STRING" id="86049.A0A1C1D0D6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00261"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10203"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="PxpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="5-OXOPROLINASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698:SF2">
        <property type="entry name" value="5-OXOPROLINASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160467">
        <property type="entry name" value="PH0987 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="497"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="577" mass="63668" checksum="5664B3E723D8DD41" modified="2016-11-02" version="1">MTREDREMMYTTKWRVGHNSNRTGIRLEGPKPRWARSNGGEGGSHPSNILDYGYPSPGGLNWTGDDPVAFTMDSPNLGGLICSTTVVAGDLWRLGQLKPGDHTSMRPISYTQARELSGRVESYIEDLAKLISGATDDKPTLDLSLADGEAGPAILKQVPAEAGRPAATYRQGGDCFILLELGEQQIDILITVRIRLITSKLMEMKIPGVTVVPNVTALLVQFDPKLISQDKLLDILSGIYSSVELTKSTKIRTREFHLPAVLDHPVLQEGIAQYMATTRPTAAYLPDNVEYLRRNNGLATRREAFTRCIDTPFLIVAVGFLCGAPELLPLNPMNQLRAQKYNPSRTYTPGGTIGMGGSLFSMYPVEQPGGYMLVGRTVEGWDTYGTKQGFSPDKPWMYEPFDLVYFHEVSLEEYDTIHRDYFAGKFQYDIREGLFDVDAVVASIEASKQDPAYIAFKDGQRKGVEEQLALETRLYAEWKAQKEAEAAEEAIRLKELVREELDPSMQVTSPMDANVWKVLVGEGDTLKKGQVLVILEAMKMEINVCAPDALDGAVVKVVATKPGHTVAPGSMLVVGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0Y6</accession>
    <name>A0A1C1D0Y6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">msh6</name>
        <name evidence="15" type="ORF">CLCR_00763</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0Y6"/>
    <dbReference type="STRING" id="86049.A0A1C1D0Y6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00763"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01650"/>
    <dbReference type="eggNOG" id="KOG0217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032137">
        <property type="term" value="F:guanine/thymine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032138">
        <property type="term" value="F:single base insertion or deletion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043570">
        <property type="term" value="P:maintenance of DNA repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000019">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000771">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 11 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="14">
        <location>
            <begin position="1045"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT54375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1214" mass="135357" checksum="263D917341DF743D" modified="2016-11-02" version="1">MPKKGASTPTATPALKKSSSTGGQKTLLGFFQKTPSSSSPAAPSARPAAAASTPAPSKSRSKTVNTTSGSSLTPVPSSDALEPEHEDIPNTKASLPPSRSLPSPVSADGEQTNGTGDLTSRGTPSRRAKTKKINYLESDSEGTDGDDVFKPKAAPKSRPTKRRRLFDSDTEDVYEQENEVEQEDDIDDFIAPDDSEDDVRPIKRKRSSKSTSRTASSHFVPTADEGRDLEVDDVDIPEGSSTAQQWTYDPEKPQPLQQRPTNIPPKQPSGKKQKAHMTEPEQRHAWLEDVRDIDRNPPGHPDYDPRTLYIPPMAWRNFSPFEKQYWEIKQKFWDTIVFFKKGKFYELYENDATIGHQLFDLKLTDRVNMRMVGVPESSLELWANQFVAKGFKIARVDQQETALGKDMRERDEKSNGKKSKEDKVIKRELACVLTAGTLVDGAMLQDDMSTYCVAIKESEKDDLPAFGVAFVDTATGQFNVSEFIDDADLTRFETFIAQTRPQELLLEKSGITTKTLRILKNNTGPTTIWNYLKPGKEFWEGHITAKEIEAEDYFPTGWPTVLEEAREKDLLMSALGALIQYLRTLKIERDLITMGNFTWYDPIRKATSLVLDGQTLINLEVFANSFDGGIDGTLFQLLNRCVTPFGKRMFKQWVCHPLMDTKKINARLDAVDSLNADAKVRDRFTSQMTKMPDLERLISRVHAGTCKVQDFVKVLEGFEQIDHTMSLLRDGTGRPSDSEGVIGQLISAMPDLGPRLKYWHDAFDRRKAKETGILVPEPGVEEDFDNSQATIDSINKKFDTLISKWRGELGSNKICYRDNGKEIMQLEVPLKVKVPASWDQMSATSTVKRYYFPELRALVRKLQEAQETHSQVVKDVARKLYAKFDENYEIWLAAVKIIAQLDCLISLAKASTSLGHPSCRPEFVDEDPETGKATLELVDLRHPCLLTKVDDFIPNDIVLGGASPNLTLLTGANAAGKSTVLRMTCIAVIMAQIGCYLPCASARLTPFDRIMSRLGAQDHIFAAQSTFFVELAETKKILAEATPRSLVILDELGRGTSSHDGVAVAQAVLHHLATHVGCLGFFATHYHSLSQEFAHHPEVCAKRMKILVDDADRRVTFLYKLEEGTAEGSFGMHCASMCGIREGVIERAEEAAKQWEISHVMHAKLNRGTDKREEGTLEEPPLGILSDVAWILKAKGDDIGDRALEVLMKCIEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1J7</accession>
    <name>A0A1C1D1J7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-directed RNA polymerases I and III subunit RPAC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpc19</name>
        <name evidence="5" type="ORF">CLCR_03137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1J7"/>
    <dbReference type="STRING" id="86049.A0A1C1D1J7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03137"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04841"/>
    <dbReference type="OrthoDB" id="510325at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="4">
        <location>
            <begin position="41"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT54743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="140" mass="15865" checksum="A59B898B9F637911" modified="2016-11-02" version="1">MSDEDPNSQEAPERRWEEAEELWLGGAKKLVVLPGASSHAVSFQIEQEDHTLGNALRYFVNKKSAGFADRYCNSPDVEFCGYTIPHPSETKMNIRIQTWEDTKTTATDALRKGLEDMIEACDVISEKFHDARDEFDPQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1L8</accession>
    <name>A0A1C1D1L8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1L8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02776"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04730"/>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="90502" checksum="ECE430D053651373" modified="2016-11-02" version="1">MPNRCFEIPFLSSSDSSDGPYDNQDFSTYIDRKAGWTVDDIVGPKQSSHSQTALADTIQTWLFFGLVHEAFGHHARQREFIDVGSSGQPLVTTAPLWRLCYDTFVSPVHPEQSSRSHELEKSIALAAEFVGRIHLDLQDDVDEQLEKVLYSIMILCDALQLSVNPSTTVLPSRQWPLSDVLLENHMRSVGWCPSDIQKVTKMLDLHSLTLASRLPPRDPGSHDRCDDVRCCANDVVAGEYQRKHHSCDGCDEFVADPAEICDILEDGHLPLIDPRQGNGSKLRLKSTGEVPNYIAISHVWSDGLGNPHRNAIYRCQLRRLQELACCVPQPALPLWLDTISRPRDYEHMRERARKAYDQAIAFMRRTYRDAETVLVLDHSLLGVDSKNLTHLGILLRFITCGWTRRLWTYQEGVLARKLLVQFADRVVDIDEVYSRWQDSSKAIFHPGVRGAYKELRILLDSGDDDYTEKILHRVSRPLQFRKTSVSSDEALCLSTLANMSPARVKRVSESEKDKRMETFYTNLPTISKQIIFWHGDRLQQMGFRWAPASFLNNSNLYFRDWDHGTSAEYNKATLSRSGLSFDCPGILLGKLNAGLQSFLVTTGSDVWYHVSCRQFDGQEGRPFRMVPDQSMPDVSLALLNPTPFREDFTTPGFETRISLIVAIVAEEDGTFIAQTLCPAFVFRKVGIETELPLVMKTYRFFRTILQEQHTSDGNGDSDSQIDVENAWVLEDKSLMGQYQARGRAAVVEHVQSPGSDHGENLLWAGTTMLNGRLCLVREGMHNIFEGSEIPSRQRWCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1Y4</accession>
    <name>A0A1C1D1Y4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1Y4"/>
    <dbReference type="STRING" id="86049.A0A1C1D1Y4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03220"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04870"/>
    <dbReference type="eggNOG" id="ENOG502SBBE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="531564at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044980">
        <property type="entry name" value="NDUFB2_plant/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="62" mass="6875" checksum="2737C6FD7F8B30E9" modified="2016-11-02" version="1">MAGAPSGKPVWKGNHPVGQINAAPRLYRVAATGLGAAMWFFLFYRMKQDGPALLGWKHPWDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D241</accession>
    <name>A0A1C1D241_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D241"/>
    <dbReference type="STRING" id="86049.A0A1C1D241"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02823"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04864"/>
    <dbReference type="eggNOG" id="ENOG502RWAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5348779at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="637" mass="71772" checksum="6CE75A0AA605BD5A" modified="2016-11-02" version="1">MSPIKVPLGRDADTDTDAGAPRLEIDEEGVARAVFPKHTTKRHCVTDNETARLATHEHGVAQTEDPDSNKKKFHLGPMHPAMTGLHLRVGRHRESYARTKLVEPPSSAEPGKGPTVLDNDEMVEEETEENIVPRVAPIAARQIVDVEAEDTEEEMVVAGRAVVASGIESAQELAVGAAILDGPDLPPVFTPWEFTASPRPPDDEIADEELARRYPALRGSEILHLLARGAANRDPDLPQILDHGPAEVSVMTVHENAEEAFVGWVSMPQGPGAVPLIIPWRPIALPFYPADPGYVQPQLGQWEQSHHEQFLEEQYRREAQAQDRENIPLLPPVVFMQVADARTRVRASSTILTIEGEKLVRVDDTHFLYAVNAEYLLGGTNTTIRRYQCGHWPPHVPSVANERAVRPAVLFELYPTGEYAYTAENGRRKQAPQEFRPQCDIFGRILLNAYDRPLKFSKLIPYKVSTEIEGWEMEALCRLDADLCNQDFLDRMLPDTAVGGSGRGRGRPSRGTLNNRRRRDRMRLRILPWPVPHDLSYADQRLIKELDDWGTQENTTVHLRDLMKDEIDMHEAIMYGGHFERSGTRHALQDQARLEQLRVNLRLVRTKFAEDSDEVQLVKDRVVRLLQKMGREDDAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D242</accession>
    <name>A0A1C1D242_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D242"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03141"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="159" mass="20511" checksum="10E71E18321C7823" modified="2016-11-02" version="1">MAESFVGEMVLTCYRIESEIGESYRLACLGRLKFSSSKWHGIACKYKYKYKYRYKDKYKYKYKDKDKYKYKDKYKYKYKDKYKYKYKYKYKYKYKYKYKYKYKYKYKDKYKYKDKYKYKYKDKYKYEDKYKDKYTYTQNILNNIYPAILLFGEASWPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2A8</accession>
    <name>A0A1C1D2A8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase-activating protein GYP7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GAP for YPT7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GYP7</name>
        <name evidence="6" type="ORF">CLCR_02756</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2A8"/>
    <dbReference type="STRING" id="86049.A0A1C1D2A8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02756"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05115"/>
    <dbReference type="eggNOG" id="KOG2197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021935">
        <property type="entry name" value="SGSM1/2_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12068">
        <property type="entry name" value="PH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="448"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="766"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="818"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="792"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="818"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00072091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT55023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="887" mass="100042" checksum="4FFEFD09B33CBF36" modified="2016-11-02" version="1">MTSAPSGRRDAPSPSASFYDLSDDEEGGYNTIAHASTSKGVKLLFSKSKVYVHPTPSAKDNIPGFIALVQQKPAPLSSDDQRPTSSASSASKKQTNASSYLLAWVPEASLAQDDLSTYVKVDMKDSQSPPKQSYLVPPLPLATTFDESPVGPYAFSLPLSSIYSIHVRPPSLGWWYGSIVINTRAGSSLPALFFHDSECESTILQKKKRAKESFDPFGESGELFWGGDEVLKWLKRYVAVERSTAEPSIYLIDPSEEDRLGFGQGRKSLEQAKRKDDAAAKKPVGQQKKPPGPGMDPLTKALKETRWKILEQLSKVTTFTRRTAEDLANNKNLPPQVRRLIQNPEVQTLQDEFDSAKLYLARWAMSIAEQSERERKQRIWTARDVLESEETSVGDFEILDMEAARMTLTDSKRRPVNMTEWKSFFDVKGKLSVTVDEVKERIFHGGLDPEDGVRKEAWPFLLGVYEWDSTEEQRRALMNKKRDEYIQLKGAWWDRMIDGNATPEQEEWWKEQKVRIEKDVHRTDRHIPLFAGEDIPHPDPTSPFYSPVGPGTNVHMEQLKDMLLTYLEYDTPPSAGASSSKYQTTNPSPQNLGYVQGMSDLLSPLYAVFQDDALAFTAFCHFMARMSRNFARSQLGMRAQLNTLDQLVQLLDPKLYMHLQSADSTNFFFFFRMLLVWYKREFEWSDTLRLWESLWTDFYSSQFHLFIAVAILEKHRDVIIDHLKHFDEVLKYINELSGTMDLQEMLIRAEALFKRFEKTVEAIDRKETFPMPSGGGGELRQRKAGVGDAQDTNAGGTQNTGVVVTGSAATGASVLRTQNQNQSQNQKHNAASSSRGQIPGQTQAKGKEAEKIKEKVITPELRLLLSRKVITLDGEDVPATRASGLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2U9</accession>
    <name>A0A1C1D2U9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anucleate primary sterigmata protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2U9"/>
    <dbReference type="STRING" id="86049.A0A1C1D2U9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02710"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05191"/>
    <dbReference type="eggNOG" id="ENOG502QWE7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13365">
        <property type="entry name" value="PH_PLC_plant-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF1">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1192"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="621"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="687"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="772"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="914"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1338"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1506"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="960"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1009"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1077"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1124"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1343"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1382"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1394"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1424"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1537"/>
            <end position="1560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT55102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1569" mass="170288" checksum="211C6E73F9C4E7A4" modified="2016-11-02" version="1">MAAAAVAGSDDSLNNGLHASVDGMTDPFVDDGQSRHSSHAHRYSSLVDPESIALGASMSPSHVKRSLVAHLAETERRLQDTQKLGESLLMQQSELNDKLREVEEQQGEAEITPELRQRLAELEKEHNDVGKEIARALLGPKSRAVSGEEKPGLEPSVYASQATASPSKVMAPSRRQRNQPSNRGDDLQLAADISTSFLAQVRQLQVAVAERDELLKEAKSERDRLEREAAIHTQRLRALDESEQKYKDENWNLETQTHELLAAAREAADREKRLTATLATTTAEKTRLQSEMDEIRVAYEKLSTDHAAAKKAHDSELHTLKRTIDLGDSDRSSLQHKIEELTAQNQELARAVAARIRTAQPEMAPLTDEQEESLEDVDPLEQSPPPSPTKATPRPGALESETLRSSLHHAHRMIQNLKNNIHREKTEKIELRRMLQDARDELEQRRGDSSFGSGNKRQKTKSDTFKKQIRPDMLGGNRRARTDVELEDEDWEDHTVDTPTHGFAPRHLAVPGRGEGTTDASDAYQTANETEGNFETADERQTTESEDFQTGAESLAGDSTDDLTETEDTASHRAGPRHGPRPTLTFRAAGDRQSYISTASDDDELKTPVVTQTHKFRLRNGRQSLARSRVPTDGTPTNLDPETPLQDSPATVTSERSLPAGQSLFAELGELDETTSFGTPGRVASLASATSTPGIPTYTPSRRVTQQEAPKSAVKVAMVDAGTMTEVPEPEPTLAAPMASANVTEVPVADSTRAQSPLPSDFPLPPTVPTSPVKNTDHSTQYTPQTSPIRNTAFITPPKTVWDEAQSPEADRGEDVAAPQTPMRFDYSGLVMHDTTPASPDTPQHLVPPEQKTLTFSTIQAQATEPTPPILSFTGVSAATQSDDLPGSPGKAVNGTGAGLLASAAAALGFAKSKDNSGAVVAEDETSEPERVMNQTSPENDLPLQDISGNSVASKAATPRLDKQDQERRLPVTVRHDQSSQTLLTASQIEEALRPKTAVPIPLPEPAQPAQNATRPISPTHTTGGPQTYDQDSLATMKQTVDLGPAVAAPMPSPVKRPSSVSSRRTSFTATHPPLPSDHKEAIAKASERPLSPAKELSRATVMGPPLLPASAMRRPRTPGESVRSPTRDSNAPRTSNVSRTQRGTVTSQLSHRSSVSSFASEIDERFNMHRGGQMSAHGFGTDPRIIQAITQTMIGEFLWKYTRKAGRSGMSETRHRRYFWVHPYTKTLYWSDQDPQTAGRTELKAKSVLIESIQVVPDDNPMPPGLHRKSLEVVTPGRRVRFTASTGQRHETWFNALNYLLLRGEDQQYSAGGNDITRDDLDEFNVNGAGYGATLVPGGSRMSLSSYNSRTTRGSAAQRQQLPAGLVASSSTPSMPRGSLASRTAPNSTVRRSRAEQSQDADRDRTVRASSVNRFSRMLGSVTGRTSRMSEPQPVATTPTIGQTRSEGGSIYDASVVSDGHKDSAEELRQEMLRQEEAIWSGGLENVRACCDVNLGKHDVSTLSHSHRHASTGGQGHRNIGASFSLRGSTRRREQSSTPGPAAPSAASAASAMPATTPTRQSAAVTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2Z3</accession>
    <name>A0A1C1D2Z3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_02985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2Z3"/>
    <dbReference type="STRING" id="86049.A0A1C1D2Z3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02985"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05193"/>
    <dbReference type="OrthoDB" id="4150019at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT55104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="369" mass="40925" checksum="5B8048A68F5B4ED3" modified="2016-11-02" version="1">MHNIATEGPALSPADKKRNRLGYQRTAVACGHCRRRKIRCVPAFNDTSGRCQNCSRLKKECQFFPVDLPGSAPPKRVRKPTNTSEAFNNEGDASVASSSPGGILRSTSVEHLNDVDDPLDTHLSRESPGLHGFDPSLPMSLQGPNFPNSYDAGHQHHQRQQMLIQSSYSPRPYAQDPMNPQFYQQQQQQQYGHSLPSQYSSAFNPGHLPSAMGTIAHEPTYEYQTPVSNPPYDWGQPTRSLSSDTGEELSSGFATPYRTNTFPFFEKRMTNQTLQFAPSSSSLAHPGMEGQPNATLGDFREDNPYQPMQMRVQQEWGGGGPDPARQNSAPGVGMYPQAWYPPHPNMEGMRQDEGQPQILPSQNHNARGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6L6</accession>
    <name>A0A1C1C6L6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6L6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00734"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01045"/>
    <dbReference type="eggNOG" id="ENOG502S8TD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5417811at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="119" mass="13361" checksum="81B43E8D6941E9CD" modified="2016-11-02" version="1">MASDTGFGPDVEAQPVVQQPPPVYGNFRTSMRINPDLVHWKEIQTKTPSPLTPTYDEAVNQIHRTMGYRPPSYISESGVTEVIETQRRDVDAALVNIHPLERERMRNLAAEALEGHGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C760</accession>
    <name>A0A1C1C760_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">snu13</name>
        <name evidence="12" type="ORF">CLCR_06431</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C760"/>
    <dbReference type="STRING" id="86049.A0A1C1C760"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06431"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07046"/>
    <dbReference type="eggNOG" id="KOG3387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT44350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="126" mass="13653" checksum="E2F62D01D52BAE4C" modified="2016-11-02" version="1">MADNPSAAWPVADEALSQKILDTVQQASHYRQLKKGANEATKTLNRGTAELVVLAADTSPLAILLHLPLLAEDKNVPYVYVNSKTALGRACGVSRAVIAASITTNESSDLMPQIRELKNRVERLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C783</accession>
    <name>A0A1C1C783_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase bli-4, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C783"/>
    <dbReference type="STRING" id="86049.A0A1C1C783"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06026"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07065"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF281">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="330" mass="36507" checksum="4F048A0E2671204F" modified="2016-11-02" version="1">MQSALHSVIGPRKELHDLSGRTAVVTGGANGIGFQISRQFAQAKAKVIMVNRKEEQGDEAIKQIKEETPNADVDWVGCDLGNLKEVKQVFTDLRNKLDRVDLLILSAGINTNTYGLDADGIDRHFGVNFLGQFYAVNLLYPLIRKAAKVSDVPPRIVFEASEVHRASPPDIHFGSLEEINDENFGATHLYARTKLALILLAKFILPEKVIKPNGDNVYSLSVHPGTVNTNMQQQWKDAYPGVFGNFLSWAMTTVGRDIEQGSYSALWAATAPEVEEKNYQGYYFVDPGQPGKESSQASDPKLAEALYTLSTKLIWEKVGEDALVPWDQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C813</accession>
    <name>A0A1C1C813_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C813"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06467"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="101" mass="11505" checksum="76D734BEE2A610A9" modified="2016-11-02" version="1">MRSGFKQRGKVSQELAGRKVGEHEDEDELQDEGTYSYYAYLAGNLLSPKTTNSIPTSWARPHGEIDLQLGLDAAPTKRDCLRPSKYRRPRLRREEALIKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C892</accession>
    <name>A0A1C1C892_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">adh</name>
        <name evidence="8" type="ORF">CLCR_05947</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C892"/>
    <dbReference type="STRING" id="86049.A0A1C1C892"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05947"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07437"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08286">
        <property type="entry name" value="FDH_like_ADH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF4">
        <property type="entry name" value="NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="13"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="345" mass="36471" checksum="7472DE37C0F9D2F6" modified="2016-11-02" version="1">MKALVYQGNGKCGLEDRPVPKIKDPSDAIVKVVFTTICGTDTHILHGDVPTCKPGTILGHEGVGVVEEPGSGVARFKKGDHVLINCISSCATCSYCRRGMPSHCVNGGWILGHTIDGTQAEYVRIPFADSGLHHVPKGVDEKALVMLSDIFPTGLECGVQNGKVQPGSTAAIVGSGPVGLAALMTSKLYSPSLVIMIDRDPSRLKVAKRLGANHTVNSAETDPLEVVMKLTDNVGCDTVMEAVGVAETLEMAQDLVAPGGTVANVGVHGKSCVLKIEKLWAQNMSLTTRLVDTVTTPMLLKLFASGGIQPGQLITHEFSFTDMAQAYTTFKAAAQHDALKMLIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8Y4</accession>
    <name>A0A1C1C8Y4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_05615</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL67 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8Y4"/>
    <dbReference type="STRING" id="86049.A0A1C1C8Y4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05615"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07581"/>
    <dbReference type="eggNOG" id="ENOG502S5F1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5333655at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024629">
        <property type="entry name" value="Ribosomal_mL67"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184">
        <property type="entry name" value="MITOCHONDRIAL HOMOLOGOUS RECOMBINATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12829">
        <property type="entry name" value="Mhr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT44912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="633" mass="70733" checksum="D04099C7889874B4" modified="2016-11-02" version="1">MAATATSAMAHQLPPMSIPAMPRIRPPRLLKGEPHPNNATIPPISPDSPSAKWVQGKWRTGNSKAVKNKKATQDIQVTKALRHQTHGLDIYAYRHIRTNQVVYSLTRTLQENKVLAQLLYHGKKTVPATVRNDMWTPYFSIHFPPTPAGALEGLFAFQKLRELSTQRQLSPPENLIRASQEDIDIVKSKLGSPTTLQEMAARDELQGKIPKLNEILPKKLRAQKLMDQKATSVADAAFVLDWILSGPSPWERVTTVAKNRAIKATELSRNSVARLRKIRKEIEQKAAEIRRRASLAVESLADGDRASLRLTFDAIRQLSMEHRSIISEKGDKLDDPDNQPSIDLDNLQQYEPSGTKVKVNRKEPLAVQRQQRRAILEAENNAFKERIQTAKSAEHEAIKEWFRHNETPGTEMGSLWDSVSLARENALDSYDTQHKMSKIAAAGEAETGSNQDNTGTATTKPDTVQSSLSALKPDWATEPRSVKMYWADVNDGLFASSWPRNVIHGSLAPFGVAKAWTWAPHLDEAGNLITDSPRVKVAKVVGKSVHVMGSSLDDGWVTEEMLQGGKRPPVWAEPPPPPPPVPQEGIEDVQVEYQRLDEGMASSRDPAVFHDEDIVVEERRQGLWARVRRMFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9A5</accession>
    <name>A0A1C1C9A5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation machinery-associated protein 46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TMA46</name>
        <name evidence="7" type="ORF">CLCR_05953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9A5"/>
    <dbReference type="STRING" id="86049.A0A1C1C9A5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05953"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07756"/>
    <dbReference type="eggNOG" id="KOG1763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="167"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="167"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT45086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="389" mass="43696" checksum="9E951EEAC30F99F6" modified="2016-11-02" version="1">MAPKGKQQEPKKAKATVDDKTFGMKNKKGGSAKKQIAQLQAQAKSNKSPEEKRKEAEKEQRLKEKAAAEKAKAEAAELFKPIQVQKVPFGVDPKTVLCQFFKQGHCDKGKKCKFSHDLEVGKKVAKKDLYQDTREQEKEEKEKDNMDDWDEEKLRKVVLSKHGNPRTTTDKVCKYFISAVEDGKYGWFWTCPNGGDKCMYRHSLPPGFVLKTKEQRKAEKALMDKSPLNTLTLEDFLESERHKLTGTLTPVNPETFAKWKKERLDKKAAEAEALKAREATGRAMFESGNWKDSEDEDSEDDDDDNDDGEDQGAWNLEAMRKETERIRQLKEEERLAKANGEPVSDRNDDTDSNDAESQEGGDDADGSDDDNGEGSSGTNGESSGTKDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9K5</accession>
    <name>A0A1C1C9K5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9K5"/>
    <dbReference type="STRING" id="86049.A0A1C1C9K5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06067"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07813"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="345" mass="37822" checksum="9063E21CE0473E28" modified="2016-11-02" version="1">MSTKPLVLLTGPNGYVGAHVLHTLLSHNYRVRGTLRSLSKATYLTKQYPEASASKDLTFVEVPDIQAPGALDQAVDGVDFICHVASPYFTVSADPINELVNPAVNGTRNVVSSALKSKSLKRLTILSSFASVVDLSKSPRPGYMYTSEDWDPLTLDEAKQDGIKGYHASKTFAERAAWEMWRDAKSKGEISWDLITFCPPMIYGPPIQELDVSKGVDGLNTSIKRLVVSIQGKDPNFAPKVATPGLPAWVDVRDVAEAHLKGLSLDSGINERFLLCGGVDYFEDGLAGLRAKGEKGLGEEGAKVDRTQHFTLDRSKAEQVLGLKFTNFQKTVEDTWEQLKKLGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAK5</accession>
    <name>A0A1C1CAK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_01579</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAK5"/>
    <dbReference type="STRING" id="86049.A0A1C1CAK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01579"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03409"/>
    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF115">
        <property type="entry name" value="DIHYDRODIOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="15"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="149"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="419" mass="46265" checksum="F61B9AAF12FDA436" modified="2016-11-02" version="1">MSSPREIRWGIMGWIAQTFVKDILLDPATRGVTDIRHVVTAVASSSSVSSAEKFVANFVTPSQSAKSAVYGSYEELVKDSSVDIIYIGSPHSHHYQNAMLCLSHNKPVLCEKALTVNAAQAKILYKTAKEKNLFFMEAVWTRYFPLSKAIRKHISDNDIGEVIRVTSDLSIGAVPEKDFDLGHRMVNLDLAGGALLDLGIYALTWVFQTVYHTLSAELQQQSRPRMVGAAMTPEPRTGADESTLMLLEFPKSTPTGKTKTHAVATTAMRVSDDPARNHAGNGEIETPAVRIQGEKGEIQVYGPIYRPTRYRLVPKDKGSDILDRHFEFEGGAHGMTVRMRPHTLVRNLSLSQPLMFVQYEADEAAHCLVAGKLESEGLPWAESTLIMEIMDEARKQGGLVYPDAIESTDYPVKLTAKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAR1</accession>
    <name>A0A1C1CAR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01731"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="175" mass="19783" checksum="01588D886E5ECC6C" modified="2016-11-02" version="1">MSPLFTKWTTKADRSLLLPASLCHDHAEDGATAISCAPHARPNQKPKTAICRRRSPFLLDIIAPRFSGPNARHKSETEQRLYSLLVVPYGPKRSFVIVTTAKDFSVSLTLRLKSQFNLTNTADHPNLVRKEALRKVGAHEGKKVRNRQDLQPCRSSRGSKEKRSHVFISYARRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAY9</accession>
    <name>A0A1C1CAY9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable beta-glucosidase btgE</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Beta-D-glucoside glucohydrolase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Cellobiase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Gentiobiase btgE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CLCR_01454</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAY9"/>
    <dbReference type="STRING" id="86049.A0A1C1CAY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01454"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03535"/>
    <dbReference type="eggNOG" id="ENOG502QS0R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4082933at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF24">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650672" description="Probable beta-glucosidase btgE" evidence="16">
        <location>
            <begin position="20"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="151"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="393"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="412"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT45629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="707" mass="72736" checksum="576DB5BA1169E0F0" modified="2016-11-02" version="1">MRAVTIAAAGAAVLTTVSATSHVKHMHAKLHEHAARDTWVDWNTTTLAASNTPVDGKTTKAATTTKDTPVKPATTSPAASTTSSSFLWEDWSSSSSAPVDPASTSSVTTSSFDWADWEASKTSTTTSSKPVKAATTSSSSSFDWADWEASKSSTASTPVDPATTSKETSSTFDWADWEASKTASATTPVDPATTATETWGDWDSSVAVDPTTTVTDKSAETETEHESWADWSTSVPVDPATTSSETTTWGDWTAAEETTTITLASTLTTTKYVEPVSTESVTWADWESSSSTSVAAASTSSDVPAWSADPHGCVVSIITSYGAPTWYPTPVVATNTTTTSTSSVVWGDWTSTSSTPVVAITTSSSTSTYESWADWTASASDSATVTASSEGWTWTATDGWGSGSTPSASAPGGWGPSPSGGSGGGSQSGNGGSGSGSSGGSGIHANGDSWGLTYSPYTAQGGCKDAGTVAADLAVIAQKGFSTVRVYSTDCGTLENIGKSARDNGLKLILGVWISSTGISGAQGQVWDIINWGQWDLVQLIVVGNEAVFNGYASAGELAGFIGSSAQAFKNAGYSGAVTTTEPLSIWEDSSSASAFCSVVDVVGANLYAFFNAAVTADKAGGFIQAQINILNNVCSGKPVFVLESGWPHAGNCNGAACPSPENQATALKGIQSTVGAQVVFLSYEDEPWKEPGQFGVEQYWGCSGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB87</accession>
    <name>A0A1C1CB87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB87"/>
    <dbReference type="STRING" id="86049.A0A1C1CB87"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01451"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03632"/>
    <dbReference type="eggNOG" id="ENOG502RQQT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3365211at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="679" mass="76016" checksum="EDB0C89FA460EABA" modified="2016-11-02" version="1">MAASQPGSRRISAVSNSNTEPFPSMPESPAGPSSNNDNTTTTTTTTTVHGPTITTTIHRGRPYTITSTQPTNQTPASIVSAPDNSVTTTSAGPATTRTTLLTPSQANRTRPISIRRLPSTNLRAGCEENGSSLPPSRSASGRGRSTSAPQPPHLTVPGSNNLTRQSTRQSMLPTVAENPQAAGDAIVDRETMNENVTGGVSRRRSVSNTARSIMSRFSDTSRERQGPEYESEVVDLLDVLDPEVSTLTTLNNVQNSLFVPDLGRWVNRRPTYNLSRRTTQTRRPEPVKEETGMAPIQRQATGTEEPAPEPLEEDVAPPETMQRTWSWQRRPQIERSHSITSVVTDSHYAVLPHGVSLEGWSEEDKEALDDHVRHMLHSKRSKFKQRMIAFGKYIQKPLGFFVFLYATLITLFGLAWVLFLIGWIYVGDRKDYITNVIDNVLVALFAIMGDGLAPFRMVDTYHMIFIAHYHHKSWRLRRERALPKLHDHNDLPAQREKEADPESGKPEDSEFSVLNPKQQQKLIHHQAKFSKSHSFYKPHETGTHYAFPLHLLVAIVVLLDCHSLFQIALGTCTWAIDYHTRPQALTATILSCSITCNITAGILITVGDRKTRKKDVALRMQRQELTQTAIEKVEKHKREREQQAEEQAHLTDAPRNFEVIDEETTTDSNFPSQVNSRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBF7</accession>
    <name>A0A1C1CBF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_01726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01726"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="97" mass="10802" checksum="737B96B39C962286" modified="2016-11-02" version="1">MAVENELVSPSDILVIVLDFTEPEVIQYLHHSLIRAGPIPKVLDEACKDVESVSLLYCGSWKQTYQSAVELKGSPQPPALTFLESKAKYQSEQLEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBI0</accession>
    <name>A0A1C1CBI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">srpA</name>
        <name evidence="17" type="ORF">CLCR_01522</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBI0"/>
    <dbReference type="STRING" id="86049.A0A1C1CBI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01522"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03755"/>
    <dbReference type="eggNOG" id="KOG0780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP54 helical bundle" evidence="16">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="103"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="15">
        <location>
            <begin position="104"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT45865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="521" mass="56266" checksum="A35391142C350BB1" modified="2016-11-02" version="1">MVLSDLGRRINAAVTNLNREANLDEKAFDAMIKEICAALLSADVNVKLVKSLRRSIQSAVNFKDIPPNTTANHKKRLIQQAVFEHLVHLVDPHVEPYKLKKGRPNVIMMVGLQGAGKTTTCTKLARYYSARGYKACLVCADTFRAGAYDQLKQNATKAKIPYYGSLTQTDPAVVAAEGVSRFKKEKFEVIIVDTSGRHRQEEALFEEMVLVQDAIKPDQTIMVLDGTIGQAAESQSAAFKKTANFGALIITKTDGGAAGGGAIAAAAATHTSIIFLGTGEHLSDLERFDARSFISKLLGYGDMSGLIDHIQTISRESAGIKETQKHLAEGIFTIRDMKEQITSIMKMGPLSKIGSMIPGMSGLMQGMSDEDGSEKLKRMVYIFDSMTAKELDSDGKILLSQPSRMVRIACGSGTSVREIEELLTQHKVMSSVAKNMGQQKKNMAKANSMLQGGNKQQQFAAMQKRMQSMGQGRGLPGGDMGKMMEMMQSMGLGAPGQGGMEALMNSMGGMFGGGAGRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBQ5</accession>
    <name>A0A1C1CBQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein MGR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MGR2</name>
        <name evidence="7" type="ORF">CLCR_11238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000018">
        <property type="protein sequence ID" value="OCT45892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBQ5"/>
    <dbReference type="STRING" id="86049.A0A1C1CBQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11238"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00046"/>
    <dbReference type="eggNOG" id="KOG4096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5409308at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT45892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="108" mass="11628" checksum="598F282DF9BCAB54" modified="2016-11-02" version="1">MPPIPPSAQRHGPTWFDKLKMGMLMGGTVGGIMGFIYGTVTIFQYGAGQAGVMRTLGKYMLGSGSMFGLFMGIGSIIRTDSPAMASSIWARSQYPPLVHQRQLSAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBX2</accession>
    <name>A0A1C1CBX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">sterol 14alpha-demethylase</fullName>
            <ecNumber evidence="10">1.14.14.154</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">CYP51</name>
        <name evidence="26" type="ORF">CLCR_00430</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>32-hydroxyeburicol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxoeburicol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75431"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:194328"/>
            <dbReference type="ChEBI" id="CHEBI:194329"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:75432"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>32-hydroxylanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxolanosterol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75107"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:75108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>32-oxoeburicol + reduced [NADPH--hemoprotein reductase] + O2 = 14-demethyleburicol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75435"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:194329"/>
            <dbReference type="ChEBI" id="CHEBI:194330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:75436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>32-oxolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75111"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:75112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 14alpha-formyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a Delta(14) steroid + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:68068"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:68069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 14alpha-hydroxymethyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-formyl steroid + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68064"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:68065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 14alpha-methyl steroid + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = a Delta(14) steroid + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54028"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:54029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 14alpha-methyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-hydroxymethyl steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:68061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>eburicol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 14-demethyleburicol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75439"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:70315"/>
            <dbReference type="ChEBI" id="CHEBI:194330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:75440"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>eburicol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxyeburicol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75427"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:70315"/>
            <dbReference type="ChEBI" id="CHEBI:194328"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:75428"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:25286"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:25287"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>lanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxylanosterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75103"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:75104"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 23">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 24">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.154" evidence="10"/>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBX2"/>
    <dbReference type="STRING" id="86049.A0A1C1CBX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00430"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09973"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008398">
        <property type="term" value="F:sterol 14-demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 23 24" id="KW-0349">Heme</keyword>
    <keyword evidence="7 23 24" id="KW-0408">Iron</keyword>
    <keyword evidence="9 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 23 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 24" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 24" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="26" id="KW-0808">Transferase</keyword>
    <keyword evidence="25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="23">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00052067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00052625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="OCT46043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="537" mass="60611" checksum="D2D66C8098A4FF8B" modified="2016-11-02" version="1">MGLLTTLTEPLEYLRATLPTYQLVLLGLFAFVAVSVAWNVTRQLVFRDKTAPPEVWSWFPVLGNTIWYGMDPFDFFFACKEKYGDVFTFILLGRRVTVCLGTKGNEFILNGKLKDVNAEEIYTGLTTPVFGEGVVYDCPNAKLMEQKKFVKFGLTMEAFQSYVDLISSETQSFVAKGKPFHGASGSIDVVPAMAELTIYTASRSLQGPEVRAKFDSTFADLYHDLDMGFSPINFMLSWFPLPHNRKRDIAQKKMADTYMEIIKARRAAGGKRDKGDEDMIWNLMACVYKDGTPVPDQEVAHMMIALLMAGQHSSSSTSSWILLRLATRPDIQEELLEEQKRVLGEDLPPLTYDNLQKLNLNAKVVKETLRLHAPIHSILRKVKSPLTIVANTPEATKTYQIPTTHTLMSAPGVTSREPEFFPEPMNWEPHRWDEGHPLAYTRLGNDQEEFEDYGYGMISKGASSPYLPFGAGRHRCIGEQFAYVQLGTVLATMVRLVKFRQIEGKQLVPTDYSSLFSRPMAPAVVEFEKRVGMKEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBZ4</accession>
    <name>A0A1C1CBZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00518"/>
    <dbReference type="OrthoDB" id="4120608at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="167" mass="19033" checksum="C04D393CBDDD734F" modified="2016-11-02" version="1">MADAPAPPFLIGWYNLGVSLSELREWLAKFFSRRHSDENKEIISRYNYNDATHSPGLEFLTANNRTVSFGTKIGHHPDANLHQECVELSAWYDRSGSMVCAERERDRRPVVIDPSLVQGDTGDKDSDRNTSSWYSNTEIDRMVACDYCTELGMRSDPEQLSKRVTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC10</accession>
    <name>A0A1C1CC10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">mcm7</name>
        <name evidence="12" type="synonym">MCM7</name>
        <name evidence="14" type="ORF">CLCR_00375</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC10"/>
    <dbReference type="STRING" id="86049.A0A1C1CC10"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00375"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09996"/>
    <dbReference type="eggNOG" id="KOG0482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033679">
        <property type="term" value="F:3'-5' DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904931">
        <property type="term" value="F:MCM complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="393"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT46016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="818" mass="91328" checksum="80391392C77DAA94" modified="2016-11-02" version="1">MALLQYKAIADYEKQLAAFQSFLEKFETSKTSSDAAAEAIDGLHLDGDHTSDEYDFMDDIADEDRTGPRRRRKRKYMDMLQEVADRERQNILIELDDLNEFEESLGDEVHLRLVESVTNNTKHYVDLFSEAVDRIMPKPSREISFKDDVLDIIMAQRAKRNETVASAAETDAEAAAPVSTFPAELTRRYNLNFKPLTPSGTDAGKKTLAVRQVRGEHLGHLITVRGITTRVSDVKPSIRIQAYTCDRCGSEIFQPVSAKQFTPLQMCPSEECKQNDSKGQLFPSTRASKFMPFQEVKIQEMADQAPVGHIPRTLTVHCNGSLARQMNPGDVVDIDGIFLPTPYTGFRAIRAGLLTDTYLEAQNITQHKKAYQDLKTDPRIIRKIESFKASGHMYEYLARSIAPEIYGHLDVKKALLLLLIGGVTKEMGDGMRIRGDINVCLMGDPGVAKSQLLKYITKVAPRGVYTTGRGSSGVGLTAAVMRDPVTDEMVLEGGALVLADNGICCIDEFDKMDDGDRTAIHEVMEQQTISISKAGITTTLNARTSILAAANPLYGRYNPRISPVDNINLPAALLSRFDILFLILDTPSREADEELAQHVCHVHMHNRHPEREGEGVVFSPHEVRQYIAQARTFRPNVPKAVSEYMVGAYVRMRQQQKREEGSKKQFTHISPRTLLGVLRLSQALARLRFSSEVVNEDVDEALRLIEVSKASLYTDQRSHGDQTVSSRIYDLIRGMRESGAASVGSGARGELSLPRVTELVTARGFTSEQFHRTIEEYELLDVWQVANNGTRLVWIEAGDSDADHDELMGEGEGEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCF5</accession>
    <name>A0A1C1CCF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rhomboid-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_01291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCF5"/>
    <dbReference type="STRING" id="86049.A0A1C1CCF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01291"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09363"/>
    <dbReference type="eggNOG" id="KOG4463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="283" mass="30984" checksum="0C43A14E972E1B25" modified="2016-11-02" version="1">MVTTSGFTHTPVTRALILSSIVLSILSSTLSAQHLLPIKPTPHLWPYLQFTRLLTYQAAYTSSTELLFSTVLIYQFRVLERLWGSRKFLSFCAVVFWVNLLVTPAVVVFLKLGTLGWYNYLPAGCTGVVFALLAAWADEVPRIYRYKIVTGGAGTAAVAGQEAPGVTLSDKSTTYLLAAQLALSQFPYSLLPAAVGWAVGTAWMGELLPGRLGRWRVPAWMVGESSARKERGQYEGLRRRLEEEGSSADGMRNVTERVAGGREADATRGRGFGSRFVGYFTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCY9</accession>
    <name>A0A1C1CCY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_01213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCY9"/>
    <dbReference type="STRING" id="86049.A0A1C1CCY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01213"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09216"/>
    <dbReference type="eggNOG" id="KOG4765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2592092at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013909">
        <property type="entry name" value="NuBaID_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08600">
        <property type="entry name" value="NuBaID_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3HC-type" evidence="7">
        <location>
            <begin position="83"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="NuBaID C-terminal" evidence="8">
        <location>
            <begin position="270"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT46316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="428" mass="48138" checksum="D1F5FEE6066C7006" modified="2016-11-02" version="1">MPYAIETKKRKFDRILEALTDNAASPAGSPSRSSVNSRNNTSTTSLTQDTASDSSKRRRIAPIATAANPTTPPSNDLTGHYLPSSRPAFLQRLETFRYVTKWHVPSTDPINAAAWAKRGWTCVDTDTVACGVCKERLYVNLSVDSEMLKAKKQEGEAIGDEEAAEDEEEDFAISSEVYDNMVRRYQDMIVTAHAESCLWRKRGCDPSIQRIEGLLNTHSTLSGLRSRYDSLMSHPEEIPLVESLPSTTFVDPDELDQFQSNTGETPDIHALRLAICGWERKTEDVIECRHCFRSLGLWLYRGDAPAIGKLDAVENHLEYCPWRLAEAQDTEVQLPRSSGSIEEVVSQKERVPGWVLVYLAIAKNNRQRRPRPPASVAASEPASSRVSDESMTSQQREKKMKDLLKRIKEIKKPFNVKGLLKRKEKTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD64</accession>
    <name>A0A1C1CD64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MAL2</name>
        <name evidence="6" type="ORF">CLCR_01139</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD64"/>
    <dbReference type="STRING" id="86049.A0A1C1CD64"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01139"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09132"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="16"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="588" mass="68061" checksum="47632CF894A93C50" modified="2016-11-02" version="1">MSASKPNWWKASTCYQIWPASYKDSNGDGIGDIPGIISTLPYLKDLGVETIWLSPMYDSPQKDMGYDISNYEDVYPPYGTLADMDDLIRSCHDLDMKLILDLVINHTSDQHAWFRESRKDKTNPHADWYVWRDPKIVDGKRQPPSNWRSIFGGSAWEYCKERDQYYLHLFVKEQPDLNWELEEVRRGIYKSAIEFWLDRGIDGFRVDTCNLYSKDVTFPDAVTRLHGEEYQPAFEHFTNGPRMHEWLREQRQQVLDKYGDVLMVGELPGTEAAQVLQYVSAEAGELSCVFDFDVVMLGTATHGGGKKHHTVRHTLPQFKDAIRKAQDLIRGTDAWTTVFLENHDQGRSLTRFATDQPEWREKAAKMLATLMCTLTGTLFIYQGQEIGMYNHPEHWGIEELRDVDSLNAYNDVATRHKGDPLWLKKAMKGLQLVGRDNARLPVQWDGTANAGFTTGKPWIRVHDDYEAVNVAAQQQDRGSVLNFYKKMIKLRKEYAELMVFGQDFSVWDFHDQDVFTFTKSHPDRHGEQLLVFLSFSDEEQPMHYPQGLENVKKHLLVTNLREGEEVGKYLTPWEARVYVIKESVLNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE67</accession>
    <name>A0A1C1CE67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_01967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE67"/>
    <dbReference type="STRING" id="86049.A0A1C1CE67"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01967"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01515"/>
    <dbReference type="eggNOG" id="KOG0220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002054">
        <property type="entry name" value="DNA mismatch repair protein MSH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT46799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="448" mass="49817" checksum="F892A0A48FB350DA" modified="2016-11-02" version="1">MADLDSPATLPATFINAYKKNKYMECQTLDLVKMNQKLKDTHGEVITLADSTIQELIQQVRSRIHQLFKISESIATLDMLAAFAHLTTTCISGEYTRPELSTHSLMIKSGRHPIRAKLMSTTREIFVPNDVYATPQNRFHIITGANMSGKSTYIRSIALMSIMAQIGCFVPAEYASFPLSHELFARVSTDDNIEANVSTFAGEMREIAFIIRNISHRSLVIIDELGRGTSTTDGLAIAIAIAETLINSNAYVWFVTHFRDLPRILADRAGVSNLHLSVDISEDFAKMTMRYKILEGYEEEKFYGLALARLIGLPPDVLDTATHVSKVLHERNEAKKRNSRATAAARRTKLILNLREQLVQARESLSLGGNRDDGTQGSRSEEGVSAEALRDWLKNLQVEFLVRLRAIEADADAAAEDNETGAKMSDSPEEEDGEGSLTARDCFEVDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE99</accession>
    <name>A0A1C1CE99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE99"/>
    <dbReference type="STRING" id="86049.A0A1C1CE99"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02190"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="85" mass="9529" checksum="17AF57320E995E52" modified="2016-11-02" version="1">MGVQKQEAQGHAGAHLLGHARHCFDYLRQSIMCAGDVSYESAIVLPDGRLIDGVDGWGDWHMCRSWDTIWDYAVQHRGQNFSGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEE1</accession>
    <name>A0A1C1CEE1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bacterial alpha-L-rhamnosidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEE1"/>
    <dbReference type="STRING" id="86049.A0A1C1CEE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02533"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF11">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25788">
        <property type="entry name" value="Ig_Rha78A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial alpha-L-rhamnosidase N-terminal" evidence="1">
        <location>
            <begin position="178"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="317" mass="36400" checksum="000502FB41123E5A" modified="2016-11-02" version="1">MSRLEITRCGIHGFHETIGIDTDEIRVYWALRSDAESASQVAYRVIISTQRDHLEQRSSSQDGLIFDSGRVASSAQRNIICRPEHGFESTAMHFWQVMVWDNDGTMTVSSIHEFYTSYPRCSRRLPPYSPNQVYMPHTSLIFRTWFEDAPNRWKAIWIGDGGDKPIYLRKSIVHGAQKPSRVIVFASGLGHFNLTINGKPASNHVLDPGWTDYHRTVQFVGYDVTSSWDAGENVVGAHVGNGFYAGDQGDRFFWPKYKNNTYIRFGNELCFFAEIHVHYDDGRHEVIISDHDACQCLRFRRPRPTALSRRLGLPRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CER0</accession>
    <name>A0A1C1CER0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HRQ family protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CER0"/>
    <dbReference type="STRING" id="86049.A0A1C1CER0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02451"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02458"/>
    <dbReference type="eggNOG" id="ENOG502RZ1N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="47923" checksum="9289E800F5F7F593" modified="2016-11-02" version="1">MSRFDSLGKPSFTWHWRSLDDFKKTSWFTLGNYSNVILLIVFLLLAFNQIRRKQNEAKKAGYEKRYLKAPEFPEVEEQPDFDWKTTEPLQLRPFKPKYHLTMALENLPPSELLLMDKNYADRVAYRRKIMSEEGEHVVAVNDDYRVRPAVVELYQYLMGTYLPLRFPTMFKLHEAYYEAGQTFMLENLVTKALLPAKASPTIPTAMLLETLGRTVDEDFLFLLPEEDEDPSPDNKDKDYVPDTKYILEAYVCCCPSGFDPREKLGKRLASIHEPVPGYSAKLEASMDRFFARLEVGKYVRRVNWAITTNGNLYSAGKGTNHAHEGDALSQLEEVDSENTFLRCERQTLHRLPKTKALVFAFKTYMYPIKDLKNEGRGEEVAEAIDGLKEGSTPQMHFYKRGAVWGEAVKRYLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEY6</accession>
    <name>A0A1C1CEY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_02281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02281"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02337"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4525599at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="532"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="569"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="129"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="678" mass="75206" checksum="A638EAB8FF4287C8" modified="2016-11-02" version="1">MRNPSQTQVTQQAGLLIRLGKIIWYQSLTTVTSQAAIVEDENLTDNPLRGLTDIAVKADASTFHRNHDLHEIVDVETFVRGALAAKDPDEEAYDSIEGLTPIERQALIRENARDVLRQLRRLSKDFHVVLATCCLAAITQGWDQSSINGANLGWPREFGLNANLADPLAHSHDVWIFGIVNASTYISAAFIGCWLSDPLNEHIYGRRGALFVAGLFSFSTVIGAAYAQSWQALLACRVLLGFGMGAKASVVPILLAESAPRSIRGTLVICWQLFDAFGIFLGNAANLAVFDKWRRMVAAPFIPALLMLLLIPVCTESPRWLLKKGRYQAALLAWMRLHGYPTPILACRDLYFTNVQIQHETIYISRGLHNRAMPLQPANDAVAAHDTYQNEVSLTSYWTRFLQLFKVARIRRAGMAAFVVMIAQQACGVNILAFLSSTIFNDAILGGRRDPSTGSGDTNPSDDPGANEGVQRKALWMSFGFGLANFLFTVFALISIDSKGRRFLLNLSFPNMAWTLLAAGLCFLIPDGDTRVGLIVFFVLLFTLAYSAGEGPVAFIISSEVFPLVNREVGMSFAVFWNLLGAGILALTAPILAYALTHTGLLALFAGLNLVCWAAVFFLVPETTRIGLEDLNKIFEIRTLLHIKYRIEILKWAFRRRENEPRPFHIWAEEQEQQQLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF64</accession>
    <name>A0A1C1CF64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Ari1</name>
        <name evidence="5" type="ORF">CLCR_02609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF64"/>
    <dbReference type="STRING" id="86049.A0A1C1CF64"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02609"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02255"/>
    <dbReference type="eggNOG" id="KOG0777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3004402at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT47175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="224" mass="25774" checksum="21BE17277D134A3E" modified="2016-11-02" version="1">MSLDDGIIYNEKLMRLARGDEQPDRSIPVEYMMYDIWESMRAHDKDLADEVLEPAFVFMRAQVDKQRLKPMDLQTYFEYREQDVGKAFLSAIMRFSMGLHMTSEELELARPVEENCSKSISVVNDICSYEKEVRIAARGHEGGALCSSVPIMQLIANVDVPGAKRILWQMCREWEVRHRQLVDDVTRKNQSPALAAYLEGLEYQMAGNEAWSLITPRYNDVTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFY3</accession>
    <name>A0A1C1CFY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFY3"/>
    <dbReference type="STRING" id="86049.A0A1C1CFY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02517"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02069"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058329">
        <property type="entry name" value="Arp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26053">
        <property type="entry name" value="DUF8016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650842" evidence="1">
        <location>
            <begin position="17"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Scytalone dehydratase-like protein Arp1 N-terminal" evidence="3">
        <location>
            <begin position="50"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="228"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="356" mass="38106" checksum="D2A8B560101058B2" modified="2016-11-02" version="1">MEFLLLLAFHAAFAFSAPFRRNPYNYIQPLANGDALFELGNKSYIANVVNPKAVATVTFSSAAGTDEGSLPLTVIKTEASLITQDVLQGVVSSYLQADDVFSEDFLEAVLISSSAPNAILDASAIAFLQSYNIGQVFVSGSFHASGMASMSTFQSAAPPAGPYLATIKSGQLELASVYLLYADSYRDFLYGTYNSDDGTDTYIAVPAYLARYWNPMIPVPSRIYSWEDSRPLAGERVAVKDLYDIKGLQTSGGSQAWAYVTPLADGTAPSVQKLIDLGAVIVGKYKLAQFASGADPWQWQDEHYPFNPRGDGWLTCSASSSGGGCSIAAYDWLDYAIGSDTGSSMRRPAAVSGVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG12</accession>
    <name>A0A1C1CG12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG12"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03444"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01979"/>
    <dbReference type="eggNOG" id="ENOG502SRUH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5385013at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055795">
        <property type="entry name" value="DUF7371"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24086">
        <property type="entry name" value="DUF7371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7371" evidence="1">
        <location>
            <begin position="317"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="521" mass="55286" checksum="C053854EC7F4E798" modified="2016-11-02" version="1">MWNYVTVYKTVTNVPPTVTILLEDPNAVASSWASIDTAQVSQEVVEAPVSAKPIGTVTFVDSVRVSGFEATEPSNTPGASVFYMSKSVTSSMEPTIVAKVTTVTVSPLPFATSHQQNIQVNTTAAADSNVHGAFTSPYGGWNGSASAGSSLFGLATANNGSGPIGTGAYPGTLPPVSGTDVQATFTQLPSTSTVTEIATVYATVPFESVYGYDTTAYDHGTVTPDVDDLQKRQTCVWISATIGGQEVGWCNNWAGGSTYTFTSWETTTTPGFIPGIGTITHASTSTGTAATGSVTIQTSVPSSSNPPPAPTAAGCGEVGPFQIGFDDLIPNTSNASFLGTPMIQNPYNFLAWGDGWGYVPPPSDPFPPQSGDRLAQWDPSLNNTVMGSPNAGSIPPGSIGAWARNSKHYWFSADSAFVGCDNGSRNLSQVCDFVATAYHWDNNTQSEVVVATQHFHIPPCPDLVNCQLTMVNFNYLFYKLSTLQFYANVQGQLSKFWVDSINMNWYDNSCEAGLARIDRQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGI6</accession>
    <name>A0A1C1CGI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparagine--tRNA ligase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SLM5</name>
        <name evidence="8" type="ORF">CLCR_03347</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGI6"/>
    <dbReference type="STRING" id="86049.A0A1C1CGI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03347"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10407"/>
    <dbReference type="eggNOG" id="KOG0554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="344"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="562"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="651" mass="72204" checksum="A6A28C1CDDDE1F95" modified="2016-11-02" version="1">MSVYGVAGVHSSSHGYRSKEKRGSEESFAGPRPDRVALLRSRATFSTSPVNILAGLLLLTRVCVMLWRTLKSPLRLTDECLPRPPHLRLSFHRTRISVRSVGVRGLHDQKTADTTPTPPTVPHERLIAGPTNGVGSQLDKSIRVTGLVRSIRKQKKVAFARIGDGSTLANIQAVFPDPQLAKDITNGAYVALIGKWIPSQGAGQSHELRVEDIETIGDGNTSDNPIQKQSMSTDFLRTVPHLRMRTAFHSLLNRTRSHLISSISSFFSHDRNPVYQVLPPLITSSDCEGAGEAFTISPQSHGLTPGASEAASKEQQRMYFREPKYLTVSSQLHLEAHAAEQGAVFAFSPTFRAEESDTPRHLSEFYMLEAEYRHVSFEGLIARVENLVKRLVHSLQSHQTGKELLEYYADQKHRSTDAEFVDLAVRWKKLLGHWHVLDYTSVMSTLEKAYESSNGELFVHRPRWGQGLQLEHERWVVANLADDQPVFVTHYPKAVKPFYMLPSSAITHAENTAGDPSRETVACFDLLLPFGYCETVGGSLREHRLEQLIQSMREKGLLKHVETTPDSNGNGNGNGNGNGNGNGNGNGNGYPFLQPGESLGNLKWYADLRRFGSSPHGGYGLGFDRLVAYLTGVSNLREVVPFPRTWGRADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGX6</accession>
    <name>A0A1C1CGX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hsk1</name>
        <name evidence="9" type="ORF">CLCR_03433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGX6"/>
    <dbReference type="STRING" id="86049.A0A1C1CGX6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03433"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04625"/>
    <dbReference type="eggNOG" id="KOG1167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903468">
        <property type="term" value="P:positive regulation of DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060903">
        <property type="term" value="P:positive regulation of meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905263">
        <property type="term" value="P:positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905342">
        <property type="term" value="P:positive regulation of protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904968">
        <property type="term" value="P:positive regulation of spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="153"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="517"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="545" mass="63187" checksum="64282C7BCEEC11D3" modified="2016-11-02" version="1">MKLRQGARGVLKSLRAKQPNSMRAKVPRTSDTRYNVVLTDPRGGDTTDEEDETRHPEKPGRPAAGKDRQRHNNSNMAQTAIAIHEDPQYDLSTDQAETDMAQPDYSEEGESQGEGVGDGDSLSESSDESEDEVDESVVEDMRRLEESFKGISQKYRLINRIGTFSTVYKAEQLIPLDELDQENDEPMEESEAEMPAAKRRRTRRKPQIVALKKIYVTSSPHRIMNELELLHELRHSPYICPLLTAFRHLDQVVAVLPYFRHLDFRLYYRDFLINDMRHYFRCLLHGLRHVHQAGILHRDIKPTNFLYDHSRRSGVLVDFGLAERQGTDWQPCLCQESSHRRRERFMNSYAVQLLQSTQDLQSQSYPKNDSRPSRRANRAGTRGFRAPEVLFKCTSQTTKIDIWSAGVILLTLLARRFPFFNSADDVDAMIEMASIFGRKKMQGVAGMHGQVFETNIETIGERGFSFEKIILWASCRERTSDTLRMGEEQAVEFLHGLLELDPHKRWSAKEALHHPFFTEPIEDEDEREEREAHEALEEEERRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHF3</accession>
    <name>A0A1C1CHF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin NUP37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHF3"/>
    <dbReference type="STRING" id="86049.A0A1C1CHF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03332"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04452"/>
    <dbReference type="eggNOG" id="ENOG502SJ54">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5323870at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="77237" checksum="644D5C48D023B5FB" modified="2016-11-02" version="1">MHRSVLKLRERYQLSYELPHEAYASHVYPRQSSNGSTVVVHGHEQGLRLVWYAGKGFKPKKDTLAPKVNGTSKSDPMVIDLDDDDEPTAAEDTAAPAEFEEDEEEIDPYVPYRDVVRYIDIPLGTPATRIAVPQIAKDIDQASPGAWPTIYSDRIIVAAACSDLALRIISAPLDPPAPEVQDPSKMDIQIVKLEGANSHQQFVSDIAITHTGTPSGEQEGADGQTQYRPQTRSQSQARQEPEDAHAVQWSLLIASISCTGSGLLLVHRLPIRRDQILAGPEYSVPFRRTYLATSSVSAELSFNTSPYPAERHSSLLVTLPSNSTVKVYQVFQQAHPRDRRGSNATDASISSTRSVRTGGTDRGRFLITLLPPFCQQDNEVTHRRKRILGAKWVAAGRAVIALLEDGEWGIWDLEAVGPTSTTSGANLIRGQGNISGIHGGSLTRFSATSHILPFAEIKQKSSHSQPQPSSGSLAPMTPSTRKVRSEGLFHGSKASTGANQPNAQVRGSIVVEEKSSTRPSHDECIIISYADEIIYVPSILAFWKGEAKPVRLPSIRLGGQAPRSINILTISASHDNPFSASSDFDTMPSTPDTLVQTSHRLILSLNPLSSSSSLANASTLNPAPPSDQTLLASGDLDVEGMDRMLEDMSGAGATKRPMNVFTKSVGFRIDEDGDGDGDIDMAASPTPAKAGPRITNGRNVFGGETPVPKRRIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHH7</accession>
    <name>A0A1C1CHH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHH7"/>
    <dbReference type="STRING" id="86049.A0A1C1CHH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03829"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08136"/>
    <dbReference type="eggNOG" id="ENOG502RDBT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="768"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1070" mass="117316" checksum="155C624D760F1CAC" modified="2016-11-02" version="1">MSILPSTTYQSPPRLGRGRHLNTILEEKEDASHGMKSDSEGDGSDSTIIGRPAAWDPKLFTATARKTSLMKTAYPSSPVSSCEQSPASSAGEGYQRNSVRSSFGGSDAGTVFSDDCPSLASDPTSFASQSSRSSFASEKSSRNRYPALYIPRDSWGSMDGSPIKEITLGMSPATKIRLSPTALSALPRDVPAINAPPSLGDSNSSVSDSPCTTRNSAPVTPDMRQLGETWGNPPPTSQHLEIALDDDHSVILSPAEAHSDNAGASLTSPVAFTDMIINFPTVPGATPQDLSPLMPTIDEIKKFDDEVPAHGSELGVRLPPDALQLLQRLSGQKSADDLSTTSGSSRPSMKSGRRQEMRERTAPEPVSRPRSADGETPVSDYSFSQLSIPSPGGFFSSLQNASRHTWCLNKSKAPSMPNTATAESFYNRPWESGSRDNVVETVLTVDDTNLTEGPPTAKQDTFNLGHPAGRRSDHSEDDDLYGPGSDGPKASASPPVSFEYDEKYYDDLQQSAGQNLDRTGSWLAAQTDFLSAILDSDPNTQLSDDDTSEETRSKPARRTVMFAEQPKADTALGGTRQERDSPDSEPESREPIFLSAFQHLVKVRKQRDAFIHASSRLEATQNNRIALQEKHITSLLGQHTLVDPKRPKYSGPFSQNPRQTGVFERTPEQVAYEAVEREQLAVASVEQSNWQVDAMKALYHGRLLASPAACQRLKNRSTLPLDDPTCVGNKRLRILDLGGAASASWAWNAALEWPNVKVYTVISKDQARTQRPAGQAKPEAPQNHRTISVPHLWQLPFRSGHFDVISARSLHVLLKNNPVPSAPSIDEWDLTLRECMRVLKPGGYLDYMIMESSIAHAGSRAEAMSVEFGFELHRRGYEREAGRSWLKRLKREGFVGVKRAWMFLPMGKRPPEEAEEQIHGYTGGWQSWRQGAKPFVPAPRPISEVSTISKIVRQYMDVEAVQGPIGSTQDVADLTGLLGARMWEEWLVKVRAESGREESRWLEGVDEMIEEGKEQGSGWKVLIGWARKPKPTRSPKGERAEITVAVEDIEELTSGDDSIETGMIPMLIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHI2</accession>
    <name>A0A1C1CHI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BNA2</name>
        <name evidence="7" type="ORF">CLCR_04050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHI2"/>
    <dbReference type="STRING" id="86049.A0A1C1CHI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04050"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08126"/>
    <dbReference type="eggNOG" id="ENOG502QV6W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000004">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT47958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="507" mass="56892" checksum="81D18A8C45AF5F84" modified="2016-11-02" version="1">MLPPVPLPEDYGISPERGFLPSDLPLQCLSHPVYDRWERIMNNFQSLLLSKRLRAVIDKLPVIPAVHLETEAEWRRAYTVLTFLAHGYIWGGDKPSEGVQRLPPAITYPLLQVCEYLELPPVATYAGLVLWNWKPLFMSDSLALENLSVLTTFTGSLDEQWFYLISVAMEAKGGPTIPLMLDAIQAARDNDVEKVTRCLQSFAQTLDELGTLLVRMYDSCDPHVFYHRIRPFLAGSKNMKDAGLPHGVFYDDGNRQTSRWRQYGGGSNAQSSMIQFFDVVLGVEHRPTGSKKDETSESEAEPGAAPKPRHNFIHEMRQYMPGPHRRFLQAVEAVANIRDFVDFNRSNRQLTVAYDACLAMLRALRDKHIQMVSRYIIVKSRESRSMSRTRRESSPEPIPRGGTGIAGIRYGRPDEIGAAQKKKKMRGTGGTALIPFLKQARDETGEPAIDAWARKLLMGGRRTEADAEIALEDRVTRAENLDSEEPQTVGMAGAWDLEDAGGGLCAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHL3</accession>
    <name>A0A1C1CHL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endosomal sorting complex protein TSG101</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_03960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHL3"/>
    <dbReference type="STRING" id="86049.A0A1C1CHL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03960"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08124"/>
    <dbReference type="eggNOG" id="KOG2391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="7"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="521"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="374"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT47956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="594" mass="65525" checksum="5ADE2A6B144E3E0D" modified="2016-11-02" version="1">MAGLPQKTLAWLYDVLKREYHDPNRTYSDLAHVLARSPGFAPRTDVYTFETGAPALLVVFTGTIPVNFRGNTYRFPVTLWVPHAYPYEPPMCYVTPTDDMVIRPGQHVGGDGRIYHPYLAHWREHWERSNVLDLLSILSDIFAKEPPVMSRTAQLQQRAVQPTPPPVPPLPREMQPTQQVLHAASPPPAGQQLGPPAPPPPPPKQPPQSALSSPPQRSPGPDAAPSRLGRYDAPPPLPGQGQPHKFQPAHGNGEVQRPPSGISYMPQRSSSLRHSMPPPLPSQQPQPGYESHQYRTQPPRPGQPQQHAQTQPSQQPPYGSPPPTLGQVQAYNQDQYRQVSAQERPERPRSQHYPSTQQTYQPPHSVYHQQYAQAQFQAPKPAPPPQPNLLDSPFDLPLPPPTSSTSNLSSNIPAPPTPVNPEKEALLSHLSHLLTSSLHQQISQNSSALQPLSSQHAALQQTMQTLNSELANLKTLHTTLSSNISLLQSSLKSADGTISSAHSRASRNEIPAVDEMLTAPTVVARQLYDAACEERGIEAAILALQEGFVRGRVGSEIWARRTRELAREGFKRRWMVKKIGHGMGLDLDAGSYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHN7</accession>
    <name>A0A1C1CHN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04237"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08144"/>
    <dbReference type="OrthoDB" id="10628006at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="311" mass="34184" checksum="5A65E9CF83B576B6" modified="2016-11-02" version="1">MVAIRPLPDEESAVMTKDATPSSSSSSSPVDHHGRLQQQQGSTCRDAVFMLHRHRMRSHSETTTTTPPPPSPCPHSPPALRPPHHVDSGEVTAPSTSRHSRPQSAEHRRRQYGPSTMYRAYPRPPTPMPPRCWEDGSSTMGESAPFEADDDDDDDDEGDGVQGEEGADDERWALQGVASSDDEFSPAAASSSSSSSSSSSSSLSLDEAEEDDDDDDDDQPEPTWQDLRQGFDRIHSKIDVLLAEVRRRNAEHELWMKWYTGEVERMEVHRAFLRAECARRAPSSGNKKGGSGGCVDCLWHLLLLLLGATVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHV0</accession>
    <name>A0A1C1CHV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">exo70</name>
        <name evidence="6" type="ORF">CLCR_03973</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHV0"/>
    <dbReference type="STRING" id="86049.A0A1C1CHV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03973"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08251"/>
    <dbReference type="eggNOG" id="KOG2344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="249"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT48099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="633" mass="69586" checksum="01A5E7AB5B1E3D08" modified="2016-11-02" version="1">MAGPKNAAFAEESAEVEVLLASLGKTKDLTKRIAASLSRLDVSGKIVKDAIGPIYANTQQLQITSRNIEKVNEAIEKLKQPLDSRGREEGIIRAGPKSAGLPQYLGALKRVDKALSDMSSTNMRSNQQAISEFHSLLTTGVNQLNDMYRQMLQEDSQTLEPLHYITKQIPFPTFSNDKAQSLSQIAMAIASAGAQSARMGQRDDDVAARMYSEIRGDYLQGSLQNLATASIMTSKRRGDDTGVYREGSSGVGAYVKAIEGMFLAEAENTSRIFRNDAGRVLTSTCGKAMATFSRTMSDLNNVIKPRILSDCFLAYEILELVTPLSYRLEQRTGQLRPQFAEALRPLRDTARSSLSELLTQTKRQAESTSTLPPDGNTIPLVSQTATRLQNLATFDRPILALLSSIGDGNWRSAPGMASPSTLNLELTPSTENPTLLSHYLVDLVDGLLTTLNTRSQSLHPKKPLQGIFQLNNIAIVTRAVQSSPDLARYLGISPHNAKLESYRKAGSSLYLTAWRDPANHLFDQIQTSGSRPLSSGQGPAIDSTSIIKSLNSKDKDKIKEKFRLFNASFDELVSRHKSLHMESEVRAGLAREIQSLIEPLYARFWDRYHEVDKGKGKVVRYDKGALSAMLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIA8</accession>
    <name>A0A1C1CIA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04387"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08411"/>
    <dbReference type="OrthoDB" id="4588380at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="173" mass="19887" checksum="176F7586A7F9BEB9" modified="2016-11-02" version="1">MLKQVLPLSILYFTLVFLAGLVLDSVRLPYLQPLLGARYAELLETPLMIFIIWHAAQITVWNFDLDLGSTLKQSARWWSPMPLTVGLLSLMWLLTAEVGIMTILYDNWLWDALKLYFLQRDLVAGSVSGFVLLAYALMPWIVWLVRGQNGEDEAKLVLDFDSVRTEDEDYCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CID2</accession>
    <name>A0A1C1CID2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI inositol-deacylase</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">bst1</name>
        <name evidence="15" type="ORF">CLCR_03836</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CID2"/>
    <dbReference type="STRING" id="86049.A0A1C1CID2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03836"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08360"/>
    <dbReference type="eggNOG" id="KOG3724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000056">
        <property type="entry name" value="GPI inositol-deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25141">
        <property type="entry name" value="PGAP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="798"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="866"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="911"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="957"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="981"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1005"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="13">
        <location>
            <begin position="112"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="14">
        <location>
            <begin position="707"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT48212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1030" mass="114884" checksum="047074F1F5C6B5C3" modified="2016-11-02" version="1">MLLKPKEEVGDSHADNDVRGFRKIRAQASSPWTWQPLTLITTAVALLSLLVIVRSSFQLQQDPQGCVMSMMAPTYIKLSGFDTEHSRFATKYSLYLYREEGVDEYTKDNIGLRGAPVLFIPGNAGSYKQVRSLSSESSRYYHNVLRHDAQAVKAGVRSFDFFTINFNEDLSAFHGQTLLDQAEYVNEAIAYILSLYVDGNRLHHDPQLPDPSSVILIGHSMGGIVARTVLVTPKYQANSVNTIITMSTPHARPPVSFDADVVSLYGQVNDYWRDSYLQRWASNSPLWHTTLISIAGGGRDTTVPSDYTNIASLVPESHGFTVFSSTIPNVWTSMDHLAITWADQMRKVIIRSLYDVVDVRRAAQTKPRAERIEIFRRWFLTGLEDNAPKNIREAPHEVLLTLGDGSRSAVTKENNITLRQLGAQDDMSAVLLPIPSVDNTTSKLFSLLTDQLMDKQGSFDKMEVLFCSAFPLAGGLTSTPLPIQFDLSPGDPSATRLACKKPTGDAIHLPASTRLSQNAFDQVPPFTYLKYDLRDLQDHQFVAIIDKSTEINNGWVQAEIISAADSVIASDVSLPMLLLRGLNLELPPIRPMVTEIRVPSIRSSLLAYTLQIRQHGCTADTELFTPLVRQHIDSPYESKYFVNFKQGDVNLHGVAPFLPPSIDGRDMKAGVAFQIWSDPTCDSSLEIRLRADLTGSLGKLVIRYRTVFAVFPLLVVAMVLRKQFRVYDNSGIFISFSESLDQSLRLPLPVLMLSMTFFATAFTTAGSAHLVPAHYSQKNGTAIDFAQNDLLLGSQDTFFWFLVPLAGLLSVGACVVLHYAVLGFLHSVVIASSLVSHRHIKVDDGEKAIASAFVASTPRRRVINTAVLLFLVATIIPYPFAYVVACIVQLFTCARALRHAKDSRSGSAYNFFNYTYSILILMLWVLPINLPVLVVWVHNLAVHWLTPFSSHHNVLSIMPFILLVETLSSGMMVPSVRSFRWATNLLFFVLAVYAALYGMTYAYRLHYIANIIALWLVLLHFSAYQKRIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ08</accession>
    <name>A0A1C1CJ08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lactase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LAC4</name>
        <name evidence="7" type="ORF">CLCR_03817</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ08"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ08"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03817"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08580"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000018">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF1">
        <property type="entry name" value="LACTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="LacZ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta galactosidase small chain/" evidence="6">
        <location>
            <begin position="811"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="945"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1037"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="948"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1055"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1080"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1203" mass="134547" checksum="8995C62CBB4294E8" modified="2016-11-02" version="1">MQLTNTGTEGLAMERTNELLSQPTQSSPEWCNQKIFQKNRLASRSYFIPDTSICLNGQWMFVYSSSPQEAPDGHVISTQPATGSGNGNDNWAVIDVPGHWQLQGYGRPHYTNVVFPFAVCPPHVPTENPTGTYHRSFTVPSAWDESSQIRLRFDGVDSAFYLWLNGTHVGYSQGSRNPAEFDVTKFVLRDKPNYVAVQVLQWCSGSYIEDQDQWWLSGIFRDVHLIAFPGRARIDDFFVRTLLDDTYKNAELGIDLDLALIDGALISFELKESGGNVLHRDEGIEVAAKTTRYAHSIKVHNPHKWTAEAPYLYHLEISLHDRESVLLQSIRHHVGFRTVELKDGNICVNGKRILFRGSNRHDNHPHLGRAVSVDWVRRDLQQMKAHNINAVRCSHYPSHPSLPALCDELGLWVIDEADLECHGFDAAAAANLNLEGLSYDERVARTSQDAASYTSDNPDWESAYLDRMHQLVERDKNHASVIIWSLGNEAFYGRNHVAMSKWAKQRDPGRLVHYEPDGQAHTTDMISHMYTSPAELKKEAEAEGDKFTKPIILCEYAHAMGNGPGLLQTYQDLFRTHRRLQGGFIWEWANHGLWKEDPDGKKYYAYGGDFGDVPNDGTFVMDGLCHSDHTPTRGLIELKKVFEPITARLDGDQLVLQNHYDFVGLEHVKAEFTVHSLGQEYVSFRAVSDSNPAPLTRFATRSRILSAGELILPSIGPGQEGRVQLPEEEVLKFKNPDNDVDSDNHECWLLVTFRQKEDKPWATAGHTIAWHQTQLSTLRTSKRPAQHQSPDRAANSASLSLTLATSRLAYTITSPSTKITFDRTRGYISSFTHDNHPLLVDTRVASHNPASPSPLFALDFWRPPTDNDAAWQTGQWKHYGLHLMTSRLKSIAIAHAADSNSTSTSANNMPTEARTITIRAEHVLAPPSLAWHFDTTTTYTIHLAAPRSPSSSNSNSNSNNNKKNVSNPKVVMKIHTHVRPHGTFPPNLPRIGYNIQLSPAYTQVKWFGRGPLESYNDKYLSQRVDIWSSSIADTQQRYDVPQENGNRKDVRWCSVSASQQPSSPNADVDPTGAGAGGADGAEHRGDADPRGHHPVASHVDVDVDVISRTPVLPVLRASHTPGPDATDRRPYMQFSTQLYDAYTVETAAHPCDLLEGGKRRQGALWRVDADVAGVGTAACGPGTEEKDQVLTREREWTLTLEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJT4</accession>
    <name>A0A1C1CJT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial phosphate carrier protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PIC2</name>
        <name evidence="13" type="ORF">CLCR_04904</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJT4"/>
    <dbReference type="STRING" id="86049.A0A1C1CJT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04904"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03121"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035434">
        <property type="term" value="P:copper ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="82"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="179"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="280"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT48785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="382" mass="41346" checksum="745A784C389734EC" modified="2016-11-02" version="1">MVGLFPNTTALCQAFTPTSPYYKPAPKPVEKPERRRYFSSWSAADTAKGKAIELTEAAQKEYEKASAKAQAKAGGIELYSAKYYAACTVGGILACGTTHAAVTPLDLVKCRRQVDSKLYKGNFQAWGTIARTEGFRGIFTGFGPTFVGYSVQGAGKYGFYEYFKHLYTELAGEENAKQYKTILFLTASASAEFIADVGLCPFEAVKVRMQTTMPPAFSGTFQGISSITAKEGWGGLYKGLYPLWGRQIPYTMMKFASFENIVAAIYNYLPGAKADYSKGAQTGVAFVGGYLAGILCAIVSHPADVMVSKLNAERAPGESFGGAMSRIYSKIGFSGLWNGLPVRIVMIGTLTGLQWMIYDSFKIFMGLPTTGGAEEKKETAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJZ1</accession>
    <name>A0A1C1CJZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3 11">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">gsdA</name>
        <name evidence="14" type="ORF">CLCR_04707</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3 11"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJZ1"/>
    <dbReference type="STRING" id="86049.A0A1C1CJZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04707"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03091"/>
    <dbReference type="eggNOG" id="KOG0563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000015">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="26"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="205"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT48819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="510" mass="58633" checksum="EF0D0F5A8B4665DB" modified="2016-11-02" version="1">MADTIIHAEDPENAGTVELKENTVIVVLGASGDLAKKKTFPALFGLFRNKFLPKDIKIIGYARTKMDHTEYLRRVKSYIKTPTKEVEEQLEQFCSVCTYLSGQYDQDAPFQELDKHITEIEKTRKEGNRVFYMALPPSVFITVSEHLKRNCYPKKGIARIIIEKPFGKDLASSRQLQRALEPDWREEEIFRIDHYLGKEMVKNLLILRFGNEFLGATWNRNHIDSVQITFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQVLTLLAMERPISFSSEDIRDEKVRVLRAMPAIEPKNVIIGQYGKSLDGTKPAYKEDDTVPKDSRCPTFCALATFIKNERWDGVPFILKAGKALNEQKTEIRVQFKDVTSGIFKDIPRNELVIRIQPNESVYLKMNSKLPGLSMQTVVTELDLTYRRRFSDLKIPEAYESLILDAMKGDHSNFVRDDELDASWRIFSPLLHYLDDKKDIVPMEYPYGSRGPAVLDDFTASYGYKFSDAAGYQWNTQSTPNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJZ7</accession>
    <name>A0A1C1CJZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2C-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJZ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CJZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04815"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03134"/>
    <dbReference type="eggNOG" id="KOG4784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="46294" checksum="61B3D3DE4F150A33" modified="2016-11-02" version="1">MSNPKIVLYAEALTHIRQLTLHASLQTEKNEHTKILLSSDKKIITALHDGESSSIYLPTQISGTAHFTFPIEKRTEISTRLQIDDVSQLDSAKEDADGVEVPWSAGSLQENSSLYCNQCDACILTAAKAISWKDLPSENWAELMDFWFCHKPHENREPSGEHAAEVKGFSARSKLATSPGVGLVDIISFLLCGEDCTNVEEIKNSSRAGVTTLQCSSCQSRLGSRAEGEDSYRLYKSRLTLVREPGQPPERYAAAVFITTQLLSLIESSVSRKVVVHADSPAEAESEHAGLLLWIFNPDIYYSSSKRGPTAHRAMKVFYQAISDPEKYLDTNGTHHDELVVPQEDFAGFKQTLEESTEILPYSARTFQDWKVGLLDRWEKTATGSARMDENPLNKKVEEGFELFKLPAGMQELYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK60</accession>
    <name>A0A1C1CK60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Lsm2</name>
        <name evidence="12" type="ORF">CLCR_05262</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK60"/>
    <dbReference type="STRING" id="86049.A0A1C1CK60"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05262"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03000"/>
    <dbReference type="eggNOG" id="KOG3448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT48908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="98" mass="11193" checksum="734DECAFCAF415A1" modified="2016-11-02" version="1">MLFFSFFKTLTQQTVTVELKNDISIRGTLKSVDQYLNIKLDDIVVLDELKYPHLSSVRNIFIRGSVVRYVHLPPDKVDRGLLEDACRREALQGKAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKG2</accession>
    <name>A0A1C1CKG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_04602</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKG2"/>
    <dbReference type="STRING" id="86049.A0A1C1CKG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04602"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02933"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF11">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69304">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650865" description="Dipeptidyl-peptidase V" evidence="10">
        <location>
            <begin position="20"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="11">
        <location>
            <begin position="492"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT48977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="707" mass="77278" checksum="9E4E65E7D694EB48" modified="2016-11-02" version="1">MYARTIVAAALAVLPFAVAITPEQMLAAPRRSELSPNPSGELGIFSATTYSWDTHESETVWNLVNLTSGRISLLYNGSEISEIAWVGPNDTSILYVNGTNEEDNGGISLYAGDVTAIDEAYPVASLPAPYSGLKAVVTPSGNVNFLLNCLAWPNGTAYNEAFAAEPLSSAKIYDSIYVRHWDTWLTERKYAVFAGSLAGGNRYSLRGGLRNLVTNITNVTRAESPVQPFGGSGDYDISPDGSSVIFLTKNIDLPLSNYTSSQIWLVPHNGSRAAVPVNAFSGSSTPPNARGASAAPSFSPDGTKIAYLQMDGISYESDKNKIYVANADPGNFNITVLAENWDTTPDQLKWAPDGSSLFVAGPDLGNGRLFQVPLTASASFQPANITNAGVVAAFYVLPNGNLLVSDSKIWSSRDFYIIGPRGRLITSILRANEVDPELAGLGPRDVSEFYTAGSNTQVQSWIIYPTGFNASRTYPLAFIVHGGPQGGHYNSWSTRWNFKVWADQGYVVVAPNPTGSTGWGMAFQDAIQDNWGSYPYEDLVAVWEYVNSTFDYIDTENGIEAGASYGGYMTNFIQGHDLGRRFKALVTHDGMTNTQGSYSTEELWFTQHDVSLTCHGRMKLTAAQFNGTLWANRVNYDEFNPLNYITEWATPHFVVHNELDYRLPISEGLMLFNILQLRGVPSKFLSFPDENHWEIFAWINHYSGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLG6</accession>
    <name>A0A1C1CLG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA ligase/cyclic nucleotide phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLG6"/>
    <dbReference type="STRING" id="86049.A0A1C1CLG6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04974"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03268"/>
    <dbReference type="eggNOG" id="ENOG502S7CF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36935" checksum="F0501B22CB6BC818" modified="2016-11-02" version="1">MAKVAFEDLSGTTTPTTPNPYDGLILACNGDPQLIQERYAIHRLTRNAQQKEKILGDDFKGWILDEHLVKLDGPQKDASYIDPRHCLVFWGRPPQKVKTLIDVIQSKLKDAAPDLWLMPLDNLHITVMEVAHSKSEEEIDGQINKLKDHCKAIADHTCSHRARLIKPLLSYDQAALALSWVPAAGEAPSNGRTAEDDKYTYHHLRRDTYATISDAGIEVGSRYVIPSAHLTIARFNSPNVFGGDPLDGSAALDIKKRKHWVKELEMINQWLEAEYWPQEGQPIKPGGQWVVGEEKGLDFRNGTLWYGGGSTIYLGEGFVYGEENDPNGIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLN3</accession>
    <name>A0A1C1CLN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytoplasmic dynein 1 intermediate chain 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Dync1i2</name>
        <name evidence="8" type="ORF">CLCR_04645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLN3"/>
    <dbReference type="STRING" id="86049.A0A1C1CLN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04645"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03329"/>
    <dbReference type="eggNOG" id="KOG1587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="512"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="696" mass="77120" checksum="A34D8273A6A73F11" modified="2016-11-02" version="1">MSSLKEELAAKRARLAELKRQRELRQEQYTTKRQSIGEAPSPGKNTEERRQEIDNLVNTLIQNQRDRDRDSILPSPSRKGSRPSSIQDTGTGHISPQHDAEPSPRREVREIATQTESTDTSYPNYVDASAREPAPPKKEYITYTKGVQTEPYLEEPLKPQDLSDDEDLSLRHRKRLSRRDLEQEEQIRQALRKEIEEELRATLNRDSTASTISQSQQQLRFPLRTLTNNELNAVVASTEFVTFVERSSKVIERALDIDDEYDLLADYTRTSTLDDDDDDDATPYSRTSRKSHPLREAFQLFSDRYTRRRIVSDIQFSPHFNELLLSSYTKNPSAPHEPAGLVLLWNSHAPSRPEYTFTASSDVLSARFSPFHPNLVIGGCYSGQICLWDTRTSGRTGQPVQKTPQSGSHLGHTHPVYSISVVGTPNAHNILTASMDGVVCSWSVDMLTQAQEYLVLNTPPPARTDDLAPTSMSFPAADPTFFIVGTEEGTIYPCHRYDRAGAQAGVDTRIAYKGHTAPVMSSQFHPARGPVDLGDLLLSSSSDWSVKLWRVKPAAISSATASSMVAGGAAPTVVKPVLNLGREDLIYDAKWAPHKPSVFACATGSGELEVFDLSYDLEVPIAKASPTRGKNGIVPFKGLNKVAWEERRGSHLAVGGLDGVVTVFDVGKGLQCGNGEASMDEWVGMKRLVSKLEGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLN5</accession>
    <name>A0A1C1CLN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nahG</name>
        <name evidence="6" type="ORF">CLCR_04834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLN5"/>
    <dbReference type="STRING" id="86049.A0A1C1CLN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04834"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03348"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="32"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT49435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="457" mass="50522" checksum="9923F6F6952942A5" modified="2016-11-02" version="1">MSGESMGERLAAAQDRTAASSQHPATHEARNFEVAIIGGGIAGLTLAIALYHRGIALKVYEQAPQFGEIGAGVSFSPNAVQAMKVCHQGVYEAFEKVCTRNVWPEKQKVWFDYLDGYAGPKPGQERQDIAFTIRNSLGQNGVHRAAYLDEIVKLLPREVARFGKKLVDIEEDKDSGRLLMRFEDGTTAEADAVIGCDGIKSKVRQIIVGKDHPSARPSYTHKYAYRGLAPMDEAIKAVGEELAVNSCMHMGPDGHVLTFPVNHGKTLNIVAFRTSPEDWPDFNRLTRPAKREDALRDFAGYGSNVMKLLNLTKPDLDVWAIFDTGDNPVPTFYKGRICICGDAAHATSPHHGAGAGFCIEDSAVLASLLASEQVQSPSDLEAVFATFNDRRKERGQWLVQSSRWIGDCYEWRAEGIGRDFAKIEQEINERNGKIAEVDIKQWCREATEDLASRLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLT6</accession>
    <name>A0A1C1CLT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_04976</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLT6"/>
    <dbReference type="STRING" id="86049.A0A1C1CLT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04976"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02500"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT49457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="308" mass="34663" checksum="9CF77DAEC419E79A" modified="2016-11-02" version="1">MVTVAVAGGLGHIGHSIVAALKESPKHRVIVLAREVEPDPDAEAPVFKAHYESIEELTKVLVDNDVHTVISAIKVLNEDAGRAEMNLVKAASNAGCTQRFIASDWGFPIPEGAVLPQQTLRDANCAVLRGSGLEWTRFYNGFLLDYYGIPHIKTHMDPCPFVVDMEHKVVALPGTGNDRMTWTYSVDLARFVVASLDLPKWEEVTYCYGDKMTWKEFLSLAEEARGTKFTVTYDDVQMLEQGRVTELPSQKILYQYAPRSLLEPMFAQFELFITRGCFDLPEHKRLNQVFPEIKVTGVKEMLSVWRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLV5</accession>
    <name>A0A1C1CLV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lignostilbene-alpha,beta-dioxygenase isozyme III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lsdB</name>
        <name evidence="7" type="ORF">CLCR_04710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLV5"/>
    <dbReference type="STRING" id="86049.A0A1C1CLV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04710"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03965"/>
    <dbReference type="OrthoDB" id="1069523at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT49459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="516" mass="58823" checksum="45966D841475127E" modified="2016-11-02" version="1">MEGVSVLRSQQNGHTRPPAPTSFDPQAVGPTLTGFQRPIRVEGEIFNLEVEGTIPDSIAGTFYRIMPDPAFPPFIENDIWMNGDGVVSSFRIKDGHVDFKQRYVNTEKLKEERKARRALLGKYRNKFTDAVDFRVRTVANTSIVPFRGKIFALKEDGPPYAMDPATLETYGVWDFDGQWNSETFTAHPKYDTITREMVCFGYEAKGVATKDILYGSFDRHGRLTEKVWFKAPVCGFQHEMAMTENWVIFPIIPAHCDLERLKAGGNHWQWEADQPYYIGVLPRRGAKSSDIKWFYGDTAYVGHVANAWEEDGRIHLLMAHAEGNIFGFFPDKEGKAPPPGTHPNLLGKWVIDPKATELHLKKPEHVVKWDNEFLRVDDRFMGYKTRYVFGAVTDNSKGGTDWSLVGRRIGGGFPPFNAIYKKDLQTGKLETYYNGPYRLFQEPVFIPRHVKSPEGDGYLVALTMNYEDMISELVILDTQDLSKHVAMCRLPLRLRMGIHGNWVDDTDVDMHPEYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN13</accession>
    <name>A0A1C1CN13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cAMP-specific phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN13"/>
    <dbReference type="STRING" id="86049.A0A1C1CN13"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06873"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08836"/>
    <dbReference type="eggNOG" id="ENOG502RFKK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07735">
        <property type="entry name" value="class_II_PDE_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283:SF1">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00388">
        <property type="entry name" value="PDIESTERASE2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="607" mass="65691" checksum="8AAB3E7EB24DF8AB" modified="2016-11-02" version="1">MRGNNDASLDTGPEPRELGAKDGASFQVIVLGSTGGPREDNITGLLVRAPQTEWRKSSMIAVDAGAHLASMIRILQRDMPLRSDKVPPSGYSKILEEGPFAGLRFPHISAKANALHIFREILHGFLITHPHLDHLSGMAINTPALEYGREAKAIVALPSTIEAIKNHIFNDWLWPNLSDEGHGVGFVTYRRLIEGGNPRLGLGESRGYVNVCDGLATKCWSVSHGKCHRRSHSISHHHSDSFGYMPDYNFPSRRLSRISDDHGYFAAVAQQSSQNASAYVPAPNQIPMSAGPVTPGIGGGPLASSHLDSSHMFEPVPSSAFFIRNDATGNELLIFGDVEPDSVSLSPRNHIVWDDAAGKVVDEKLKAIFIECSYDDSTRNEDLYGHLCPRHLIAELVFLANCVISRRKQRTSNGSNTADGPIAGKAVDVSTKGPDMTMRQPPTSLELKRKRKRALNGDLTITPELEPTNFDTAPPSPIASSYVGTRSASSTRRKQSHEPRESGGVAPPHMPARGRNVSFQTGSVAPSVPAPATHQRSSSLPGSATYAKERLPQPLQGVTVHIIHVKDTMMDGPAPGDIIVSELRALSEEIGLGCEFNVTNCGDSIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNQ5</accession>
    <name>A0A1C1CNQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNQ5"/>
    <dbReference type="STRING" id="86049.A0A1C1CNQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06743"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09045"/>
    <dbReference type="eggNOG" id="ENOG502SG4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5339076at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018822">
        <property type="entry name" value="UPF0646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10336">
        <property type="entry name" value="DUF2420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="725" mass="78698" checksum="08D281124B800F45" modified="2016-11-02" version="1">MDASHLDDKMDVASSPFRHVDDIDIELDSVREPSVIGSVQDEMIDDAAVAADAVSDVMQDEFDEALADDDMFDDTRQAPPEQQDPDYNMDGSIEEVQRDEDEDILYEDEDDITSGPLQNDAIVEYDSNQTSQGYLEAAAEVILEDLDHQTEPTERHDFPTNESESLPISGSTITGDQLADNLDQDQSLNVSEEYLGETREEQAHQQHDALPQSPEDPNQVETAEEQTERRGSPEEPHGPRATTQPDESLVPADAGEPGQQQHEESTKSNTDTEVPKTMHPITLYYLEEEMSLFPPMLGDASSVYFLSDSSLAFEPLDKLLAACREILVGTLDHHDELVLDVPGLGLHICEDSKYAAQITLAQVIDVYLRLCHNDEGQQAQPLYCHLSSRVSLASQYAYLAAASGEGKTYAEIAADHSHSPELEDEETAVADQKQAMDSSQPSTGAEALATGDQTDNLLSTDIAENSDKPDFFELEDHAQNDAAAQITATAVDAPPPDAENSETLAGTDTSEQVGLHGDDYPRDGEQEYGYDEVPIPESAGDEPGPGKSDHSYEDRDDETTSSHTVDGDPAEASLRADGADISGAEVSGSGHGPEQGDDIFPPEDGILEPDSGYAPYDDEELFPAPQEDVGVREPDVTADIPAGDQKATLQDLAAQDPSQDVVSSTHFDDLHGQEKAQPASTASIPTLDNPSPPITPKQAKRKAEDADELLFLDLDTPDPKRRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPV9</accession>
    <name>A0A1C1CPV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI ethanolamine phosphate transferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">las21</name>
        <name evidence="15" type="ORF">CLCR_06664</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPV9"/>
    <dbReference type="STRING" id="86049.A0A1C1CPV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06664"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05471"/>
    <dbReference type="eggNOG" id="KOG2125">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000045">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="604"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="642"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="687"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="725"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="758"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="801"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="837"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="14">
        <location>
            <begin position="434"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT50539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="866" mass="95219" checksum="FB1F2D0EF0B22D4A" modified="2016-11-02" version="1">MNASVRIASLGLANILLIAALLIFARGFFPHKAFLPGLATWPSDSVAAARTAPFDRVIFMVVDALRSDFVYDSASSFHFTQSLIRSGGAVPFTGHASPPTITMPRVKAITTGSVPSFVDLILNFAESDTTSTLKDQDTWLAQLRAKDGDLVMYGDDTWLRLFPDFFRRADGTTSFFVSDFTEVDNNVTRHIPTELAKDDWSAMTLHFLGLDHIGHKTGPKGPNMPAKQAEMDTVVRDIYTAMEQEDHLNACLLVLLGDHGMNEGGNHGASSPGEVSTALTFISPKFKSAFEGRTSPVDDAIDYQYYDVVEQSDIVPTLAALLGFPVPLNNLGVIIPYLLELWTRPEDQYALMYENAQQIHRIAEATFPNSFEGQSPPEDCSLTSGDEPDILACLWQRVCADHNIATVPTPGFASASNNLKSFLYKAQNLLSGTASNYDLVNMQIGIGLSTVAFTLCLPHFLKGVVQAGFDGAFLVLVMLSYAVTMFASSYVEEEHQFWYWTLAGYLVILYCKDSRFEVAGNTSGPRALLGSATGTALAIILFGVARRWRQTGQKYAGEADIISEVVAPNGWMLWSLVMLTYAVLSRNLSRRTGVWMGSPQMGVLPALVSISAFLFKIAFTAADAPELLDSFPILNPLVRFVSAYPLVSLARVVFVGLIHLLGCAIYYETPWKGAEHLGKFLTAFQDVLSLFLITQTRTVYVPLFLFFNAQLWLLRRRRCHSITEAATLALLFQYASFFAFGGTNSISTIDLSNAYNGVSGYNVGAVGILTFVSNWAGPIWWAFGTCQLFSTAQLGTDNYSFLSTALATFACIHTLSVMVACMVLREHLFIWTVFSTKYLYTAAWVMGQHIFVNVLAIGTLLWRGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPY7</accession>
    <name>A0A1C1CPY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome-interacting GTPase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RBG2</name>
        <name evidence="6" type="ORF">CLCR_06862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPY7"/>
    <dbReference type="STRING" id="86049.A0A1C1CPY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06862"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05477"/>
    <dbReference type="eggNOG" id="KOG1486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="181"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="408"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="487" mass="53935" checksum="E6137E3C988FF505" modified="2016-11-02" version="1">MWLDAAPSIAHQTVGPSGRENATRDLSLHPTSSPYIYFGGGCWTTCPDPDLQDGEHYREDQGVRRSIIPKPSLRGLTLCLRIEAEMARTQRVARIAATLPDTLGLQNRSTHWKKTEHMLCPSIWLQPSRDDRPLGLALLGISQLTRLSSKLARLRAQLLEPGPGAGSGGGAGFDVSKSGDARIALVGFPSVGKSTFLSKITKTKSEVAAYSFTTLTAIPGVLEYGGAEIQILDLPGIIEGASEGKGRGRQVISAAKTSDLILMVLDATKRAEQRALLEAELEAVGIRLNREPPNIYLKAKKAGGMKITFQSPPKHLDEKMVYNILRDYKMLNCEVLVRDENATVDDFIDVIMKDHRKYIRCLYVYNKIDSVSVDYLDELAREPHTVVMSCELDLGVQDVVERCWQELRLMRIYTKRQGVDPDFSEALIVRSNSSIEDVCDQIHRTLKETFKYALVWGASAKHIPQRTGLGHVVADEDVVQIVSAWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPZ8</accession>
    <name>A0A1C1CPZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pre-mRNA-splicing factor cwc2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cwc2</name>
        <name evidence="20" type="ORF">CLCR_07199</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPZ8"/>
    <dbReference type="STRING" id="86049.A0A1C1CPZ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07199"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05467"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000249">
        <property type="entry name" value="Pre-mRNA-splicing factor CWC2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="194"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="373"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCT50543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="435" mass="47690" checksum="229136379B2D596F" modified="2016-11-02" version="1">MAEVVQARTTLGAAPASPSRKRSASPMGEEAASNALTTSNNENTITAPTPENGEPPTKKTKLIRRKRRPARPQVDPSTIKSEPPPQTGTVFNIWYNKWSGGDREDAALSKHAAPNRCNIRNDSGWTQADKTPGSYFCLFFARGICPKGHECQYLHRLPTIYDVFNPNMDCFGRDKHSDYRDDMGGVGSFMRQNRTLYVGRIHVTDDIEEVVARHFQEWGEIDRIRVLTGRGVAFVTYVNEANSQFAKEAMAHQALDNNEILNVRWATVDPNPLSQKREAARIEEQAAEAVRRALGERAVREIEGRETREEREQRKIESSYGLEGYEAPEVIRFNHQKELGGQRAGERGLLEAPPTEENAGDGTAVDESAIVGSSVQAQDTSEGCATTNGNGDSIFGSSTLAALRGYASSASPAPRPKPAPTAGPLVAYGSDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ91</accession>
    <name>A0A1C1CQ91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RING-box protein 1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Roc1a</name>
        <name evidence="5" type="ORF">CLCR_11348</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ91"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ91"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11348"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05369"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT50643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="155" mass="17137" checksum="779FA786B857B34D" modified="2016-11-02" version="1">MADVEMKDASLTEAKAKVPVKASKGGAAEGGDTKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQGAATNEECTVAWACLPFPLHLTLAEDPTSLPTRQQRLGVPEVRKIVVLWGREQDVKYSKEHGLCMEQPPKLQVIPPTELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQJ3</accession>
    <name>A0A1C1CQJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic mitochondrial regulator protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQJ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CQJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07102"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05267"/>
    <dbReference type="eggNOG" id="ENOG502QVMS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10052321at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021036">
        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47665" checksum="ADF0158306B494EB" modified="2016-11-02" version="1">MPPRIPSSAASFTLPSTPTIQTHCKSCFQQSFSSSPSLSQTKLREQFWAWLNGPGENFRYPLPASTNYLSAYDRRGNLLRGKDQEQNVQGESSKEKSPDDPMTADEEALEAAATETDRQGQGYTLPKESLDDLRPFPLNKNFVSQSILSEELRNEIWERVQQHGKSVRQVSMEMGVDMRRVAAVVRLTEVERRMKAEGKPLAIPYSRAVHGMVPLTTLNPHTRLPSEPHESINDLEQHPLTFPQLFYPTSESRAFNRTDAGRVFSGAPRLPDDQETAIAEGTHEAWRDNRAEIIGRLGSTRPVLKPADSRIPHPHLIAFEKDKLDRSLTPLERRARHRERLQRDEEKRQALKARQREEEEAKKTRVDLGRWQLVVTEVQSTRQGVGIDGRGSGKGAVGQRYGVPSQERKKGRVKIPTKVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQL1</accession>
    <name>A0A1C1CQL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07812"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="88" mass="9606" checksum="6A16E030A53730A8" modified="2016-11-02" version="1">MDPSTPANAQTLGPGPKYDGKLRWCGWAPGKDRGANREFPVLLLATESASTPKDAHFHLGCRVDSDGWDHLDEKFGAALVERRLVLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR40</accession>
    <name>A0A1C1CR40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_09012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR40"/>
    <dbReference type="STRING" id="86049.A0A1C1CR40"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09012"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09590"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="235" mass="26136" checksum="5E100FC154003659" modified="2016-11-02" version="1">MASIKANCRKVICIGRNYADHITELNSARPAQPFFFLKPPSSILLPDKGPIVRPRGVTLHHEVELGLVIGKTPQPLKNLRADDSKFLDHIQSYFLSIDVTARNVQDEAKKKGLPWSISKGFDTFLPISHEIPFDRIPDPHNVLLWLSVNGEIRQKDNSNLMLFNIPRMLSDISKVMALEEGDIILTGTPKGVGPMKGGDIVKCGLEVDNKEVVEARIEVAVVDDESVDGYVFKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR45</accession>
    <name>A0A1C1CR45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">cut14</name>
        <name evidence="15" type="ORF">CLCR_07919</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR45"/>
    <dbReference type="STRING" id="86049.A0A1C1CR45"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07919"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09616"/>
    <dbReference type="eggNOG" id="KOG0933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000005">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="521"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="347"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="246"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="403"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="680"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT50976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1183" mass="132417" checksum="E7C329AFDC144D1D" modified="2016-11-02" version="1">MKIVELVIDGFKSYSQRTVISGWDKTFNAVTGLNGSGKSNILDSICFVLGITNMSTVRAQNLQDLIYKRGQAGVTKASVTIVFDNSDKSTSPIGFEEYAQISVTRQIVMGGTSKYLINGHRAQQTTVQNLFQSVGLNINNPNFIIMQGRITKVLNMKAAEILAMIEEAAGTRMFEDRKEKAVKTMAKKEMKVVEIEGLLREEIEPKLDKLRGEKRAWLDYQKTQGELERLTRVVVAADYVRAGEKMKNASQEHEAKRAKVTHLEENAIKLKREIENLDEDSQRVRAVREKEMRKGGRFQAIEAQVKELSHELVRLATVLDLKQSSVAEEEQKKKDVTKNVKSLEKQVSDKKAGLEKLQSQWNSAKAEHDSQNSEVEKKEELLSTLQTGVASREGQESGYQGQLQEARARLTAATTEQEQAKLKISHLEKRIKEDEPRAKKAREQNADLLKDLEVLRKDAQKLENNLQRLGFEPGREEKMREQEVTLQKSIRELSRQADEMKRKVANVDFHFSDPSPNFDRTRVKGLVAQLFTLDKDKSMAGTALEICAGGRLYNVVVDTAETGTQLLQNGKLKKRVTIIPLNKISAFRASAEKVGAAQRIAPGKVDLALSLIGYEDEVSAAMDYVFGTTLICQDAETAKKVTFDPSVRLKSVTLEGDVYDPSGTLSGGSSPNSSGVLVILQKLNEVTKELQKHQSELQQLQETMRQERAKLADIKSVKQELDLKAHEIKLAEEQISGNSSSSIIQAIEEMKGTIVQLKQDMANAKTREVEASKDVKRIEKDMEDFSKNKDSKLKELEKSIAELKKSLTKTSTAIKSLQKELQDAKIDCEQAESDLNAAVEQLAEVNATIETQKAELETLRQEEASVKSNHDMAQGELVDEQAKLTGFDDELRELEQAKSKKSKQIAEEALEAQKLGHAVDKAQKDAQAAAQLVAALEKEHDWIEDNKDQFGRAGTPYDFHGKNLAESRATLKNVTERFQGMKKKINPKVMPMIDSVEKKEASLKNMLRTVIRDKKKIEETISTLDEYKKEALIKTWRKVTEDFGNIFSDLLPGNNTAKLVPLDDNLERIQEGLEVKVCLGKVWKQSLAELSGGQRSLIALSLILALLQFKPAPMYILDEVDAALDLSHTQNIGRIIKTRFQGSQFIVVSLKDGMFQNANRVFRTRFSEGTSVVSVMTPGELKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRH9</accession>
    <name>A0A1C1CRH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRH9"/>
    <dbReference type="STRING" id="86049.A0A1C1CRH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09287"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09724"/>
    <dbReference type="OrthoDB" id="2138648at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hypervirulence associated protein TUDOR" evidence="2">
        <location>
            <begin position="39"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="94" mass="10041" checksum="D92E2D0A075958FC" modified="2016-11-02" version="1">MSELKSKGGATIEKGDTVSTPVSIPSSLRKVGRCLLEQYRGGKHEGEIITSEKQAKQLENAKGAGHAPAVVFTDQNNKKVAHKPNTVTNLDKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRI8</accession>
    <name>A0A1C1CRI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRI8"/>
    <dbReference type="STRING" id="86049.A0A1C1CRI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09224"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06942"/>
    <dbReference type="OrthoDB" id="5586401at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039870">
        <property type="entry name" value="Coa4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="134" mass="15237" checksum="7BB4C8AFC4F2B36D" modified="2016-11-02" version="1">MSAQGNSNRPDAAEEELDDWDQRIFSTGCAGKLEITVRSRLRDVTLTNGTEEQLRMNDCYYDKKDWRACKAEVGVESPTPNALSKASPRLIGWSSAEQNSGHTDFSRQMEAFRQCWKRKGNEERTQSRDASSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSM7</accession>
    <name>A0A1C1CSM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSM7"/>
    <dbReference type="STRING" id="86049.A0A1C1CSM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08957"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06590"/>
    <dbReference type="OrthoDB" id="3182339at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="281" mass="31557" checksum="16983897CEE5345A" modified="2016-11-02" version="1">MTTETAILVSPEEAEELIPLCREAPKQVVHLLSYATPVTQKMLQFNNLNYYAVPPLPLDWSAPIWLRIQIGIFAGRLYFPFEELAHIRGFLGLGTDEASNLQTDLAIEIEGERTEGLSSSDERQTSTHNGAQVAWEEQTITKEARAAKLKATRMLTFLHAWLGTRGRGQDFTHTPMGYICARKTLTEDHAFFREIDDDESRRSRVQHAMAGDTSAPAQMDVERDEDDHSDIDEEELDARHRLTEEELRLSTESAANDEGSGDEDGEEDDEQCKSVSSDSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CST6</accession>
    <name>A0A1C1CST6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CST6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09378"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651020" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8448" checksum="079DDCB959DA537A" modified="2016-11-02" version="1">MLNFVGVVALLTWKSTFLWRGVQQQDAGYLEVYLWVQGLTGSDKHDCYDRKDPVVEMPMVPSDRMRQQTAIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTD1</accession>
    <name>A0A1C1CTD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate-semialdehyde dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="3">1.2.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NAD(+)-dependent succinic semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_08298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTD1"/>
    <dbReference type="STRING" id="86049.A0A1C1CTD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08298"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05224"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT51761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="504" mass="54821" checksum="7237D6C1D851EF10" modified="2016-11-02" version="1">MLNKKPPYAFKDESLLDHRSFIGGEWVAAASGAKFLLYNPEDNTTICEIADLGRADAARALEAAQKAFTQYKTWSHRERRWLIRRWADLIKANKEDLAAICTLELGKPYTESLVTVKYGTDFLDWFETAIERQYGDTIPAAKGENRIFTIRQPQGVVAAITPWNSPIAILRANSKGAKVVTRKVGAAIAAGNTVVCKPAPETPLCAIAVAKLFERAGGPPGVFNIITSGPSNAQEIGAEFTQSKIVKHLSFTGSTAVGRYLHAECAKTFKKTSMELGGNAPFIVFEDAELDKAAEASKFRSSGQTCVCANRIFVHSSVLDEFAKILAQKVKATFRYGSVWDAKVNFGPLYSPKALEKIEAQKEDAIAQGGEIHVAVADDVDTGALGPNFHPPTIVTKAKTTMRFMKEETFGPLAFLVPFDTDEEVIQMANDVDAGLAAYFYTRDITRLWKVSEALETGMVGVRVGLISACEQPFGGIKTSGVGREGGKEALDEYTEIKSITVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTH6</accession>
    <name>A0A1C1CTH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_08506</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the fork protection complex (FPC) consisting of TOF1 and CSM3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CSM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTH6"/>
    <dbReference type="STRING" id="86049.A0A1C1CTH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08506"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06308"/>
    <dbReference type="eggNOG" id="KOG3004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="11">
        <location>
            <begin position="76"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="173"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT51807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="486" mass="53330" checksum="CAD68C82E0BAA01C" modified="2016-11-02" version="1">MAADPLTSATVDDLLNFDSTDDEDPFNDKPSRQTKRGDESALSPRGPGKRKASDLEDTLGLDSEIKIKKQRKPIAKLDEARLLSAPGIPKLRADARMPNFLTKKLRIKGKGHEFSDVAKLLNYYQLWLDDLYPRAKFADALQLVEKAGHSRRMQVMRREWIDEGKPWYLREKEAKKKAEKEERDREKETEEKYGGEEALMSGANNEPRTAGTVEEDDSLFVPESRANGAAEHGDVSLPEDDELDALLAQQESRTTPPLLTAPKRLVEDDSEGEDDLDALLAEQETRQKAPAAVAPLPKPQSLPFGEDDDGEMDDLDALLAEQESRSKSTALQEEPDNIPSTTQRKVSPTPDENEFPIDEDDDLAALLAHPDTDTGAVRSEQAPILSSAAAELPAPDLHAMNEEAAEAQAETEADGADMFSSSPVRGTASSHMLTSAGPELDGSEEEALNSQDIDDEDIQSTKAGQEEESQGLNADDMFPSSPVENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUB3</accession>
    <name>A0A1C1CUB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">YOL057W</name>
        <name evidence="19" type="ORF">CLCR_08140</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUB3"/>
    <dbReference type="STRING" id="86049.A0A1C1CUB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08140"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06064"/>
    <dbReference type="eggNOG" id="KOG3675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCT52074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="711" mass="79496" checksum="D9CB0230E2C5F7C3" modified="2016-11-02" version="1">MDPSLRSHYLADNPPTVVRLEIAPHFAALSSKEKRYAHHLSRASFHGTRVTLAQVSPESPVIYDLILALHRACGGDYSKLSADTSVSSSDIALWLEYAAQFLGNTGNYKGFGDSKFIPRISPEQLKKLSGVNEETRKLHEQATKTGGGIYETKDVALMHLGYPEAGHMTNYYPGSPTITKEEISIVGDVLEEKKLLIENTRLRKLDSGDFELLIASGISNPPASERDLGDVTSIDLTGPLAGKKLHLVYGDYQEEMAKIALEFKKARKEAANEIEEKMMDEYAKTFSTGSIQAFVESQRYWIKDKKPMVETDIGFVETYRDPHGVRGEWEGFVAMVNQERTRAFGKLVDAAPSMIPKLPWSKDFEKDKFLSPDFTSLEVLSFAGSGIPAGINIPNYDFIRQNEGFKNVSLGNVLSAKAPNEPIPFIRQQDDELYRKYRDPAFEVQVGIHELLGHGCGKLLQETAPGEFNFDIKNPPISPMTKKPITSYYKPGQTWSSVFGPIASSYEECRAECVAMALACDFEILQIFGFGNGKEDIDNEAGDVLYVSYLQMARAGVAALEYWDPKSRKWGQAHMQARFSILRTFLDAGGGFCEIKALNGDASNPEDLEIYLDRSKIISHGRPAVEAYLQKLHVYKATADFEAGKKMYDDITGVDQWWAEKARPIVLKKKTPRKVFVQANTVLNEQSGDVKLVEYEPTIEGMVRSYFERDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUH1</accession>
    <name>A0A1C1CUH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09119"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06050"/>
    <dbReference type="eggNOG" id="ENOG502S6HE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3223416at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="210" mass="22562" checksum="EB39851A320D758C" modified="2016-11-02" version="1">MPPPSPPLSIVTPLSEPVQPSFSSTYSNATTLYITALTNHPSPPYNARLECWSLANTFTTYPTVGRALSLGNVDNATYVVLPPRSAEGWHRPPHLMFFVLLSGLAQVFAPRTNSLMPSVDMQFYAQGLAPMRGAPTTYERQWDVITIAPGSPQQVLIAGDTDMRSPGHLTYYPGDGETVALQIPISGGVVPEHSVVHEGGCTGDEGEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV04</accession>
    <name>A0A1C1CV04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV04"/>
    <dbReference type="STRING" id="86049.A0A1C1CV04"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08029"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05851"/>
    <dbReference type="eggNOG" id="ENOG502SPJ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5342924at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="694"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="811" mass="88447" checksum="FD58C6480801379F" modified="2016-11-02" version="1">MDRHGAGRRASRSLYGKIFNVAPEQALNDSQHSLDTIFPAGPSRTYTVQGLTNSPDGFFEDEKVELSDATTPNHAQTFGQSLEGPKEAIRVGFWPNSYKLLPHFAAGAISVASHRMDLVDPNVEILPGITQGGAMNALQLAAKLHELILVASLGTIIMHVAQVHLVGNHGLPLGMLANSFAIGSGDYIRTKAYWSSIMTGKAHYWRFWLLSLLATILATLAGPSSAIAVIPSLNWFHVDRPFVDDVPPFYIYNQSTVLWPNEVTKASLNAPDSGVDCVNVTFSTAVQDSCPAGGFRDTYQWAGNLLFTNSTAGTNISFPDARGDTRRVLSTQSCASDFDGRASGMSLNTFITGALTAYWAFARNNWQGLALATTRPRLSLADPVFAPRVEVMCNGNDYYNTSEVEDRSHVNFPSFTPDKQLPNKDYILPYHSTLNDTTFDWVRMPEGAENPAIGAAVRVPWEYTTADDPTDVRQATEIHACSIYAQWVPVDVFYEPRISDQVAFTIKGKLPNTCLTLPHEAAVDQPVRNITISQDYANAINQGISFSNVSIPAIIAMLQQAVFEDARVTDQVMNAFMSPFVGSARTGVSANATIDDARRSRATMISTLLAGAITDGLARIAGNGLYPYSPSMFLLNQTDGDKLIGRFLVTTAQGGEDETLNTTAADLGSLLRIDPVFDRYGYGYSWEGSNTVQFGIIVLLIHVVVAAAHSVFIFYKLVIRKEGLVSSWSTVAELIALALNSHPSPRLQDTCAGVEAAKTWRQTVTVRETYPGHLEMVVGSDEKTQFPKPQAGRLYGHLDEGVDEFFDAKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVF0</accession>
    <name>A0A1C1CVF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10724"/>
    <dbReference type="OrthoDB" id="4147198at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="231" mass="25364" checksum="DDCD08910E5E659F" modified="2016-11-02" version="1">MATPAGNTGYGPDQQNRSGALHMSLPDNCLGVCLCGRCPTFYNLVDLSPATSACSSMQGDMSPGTIWSTKMHTQTSEPFQPALDATYFELPQTLLGMASLSNGQPSLGQAGPAFYSPGISFVDESTDPTPCSSSHSDDPFATLDPISTIASRNERRKAQNRAAQRAFRVRQQQALAQANLRMHALHEELDEAISSRNHFERLFRSLSQEHERLLEKFDELLKTVESRPSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVF5</accession>
    <name>A0A1C1CVF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ceramidase</fullName>
            <ecNumber evidence="1">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVF5"/>
    <dbReference type="STRING" id="86049.A0A1C1CVF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10330"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03852"/>
    <dbReference type="eggNOG" id="ENOG502QVBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5273684at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029130">
        <property type="entry name" value="Acid_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583">
        <property type="entry name" value="ACID AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583:SF1">
        <property type="entry name" value="ACID CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15508">
        <property type="entry name" value="NAAA-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acid ceramidase N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="405" mass="45675" checksum="023FDC1099CFCE4A" modified="2016-11-02" version="1">MDTGKDVALIAPVHTIDLSLQPEDRYKALALAYANELRGLTTLFNTLLGDLGLSQRSHGPINLFARMFLRGLNSPVETAELRGIAQITGVPMYLLVSFNVILDCLMGCTSGAVKTLEKGEPWSKTRMLHFRTLDWSMDPLRKILVQLEFVRSRSATPGQILARSVTYVGFIGVLTGVREDLSVSLNFRPLHNATKRRDNMRFYLHHLLVLLGYRQSIASILRGYIIPEDPENEHAKRLEDIVEEVVPRPTTAAYLTFCDGVSTVILEKDYGTAVMRYSDTFIGVTNNDQDDDDPRLRKDNAILEQISVKDSGLKVGMEALVEESRDRLDAIAIRWRGHVRKAKRQAKKDRKDASTVERNLTVTTDEVIEWLSAYPTTNEQTHFATIMDPMSGQVVWTRVYPSPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW12</accession>
    <name>A0A1C1CW12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_10703</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW12"/>
    <dbReference type="STRING" id="86049.A0A1C1CW12"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10703"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04013"/>
    <dbReference type="eggNOG" id="KOG3372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT52625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="262" mass="28919" checksum="5216B2909C4ED3C1" modified="2016-11-02" version="1">MHSALNRLQTTFGYFTSCAFTLACIIALLSIIPVPAPTGSPRASISVRNVQVVKGRPHYYSPKREEYAQIRFDLDADLSDLFTWNTKQLFVYVTANYPSGNDGDGGLSEAVIWDTIIPATSTPYSWQNLKQKYFPDKKSSRAKTKSRRDSNPKSKTTDIVKPGVFSLNNQKPKYQITDPSGIISERGNATLHVSWNVQPWVGALIWDKGYLGSRLGTWEAGSGGRSEIFEFPPLKGSRTDAVKDKEGPKTPKAGSATPVVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW32</accession>
    <name>A0A1C1CW32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW32"/>
    <dbReference type="STRING" id="86049.A0A1C1CW32"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10580"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04093"/>
    <dbReference type="eggNOG" id="ENOG502SQDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4157427at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651151" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="30841" checksum="75E4E5D1F11D343F" modified="2016-11-02" version="1">MKLLSLAGAVAWFALNLHRAAALSNITFYSDNACQTFKGWKTGPDDGTCTPFPTNVQGYLSFMVTSLDQTCAVTVYGSDVAFCSSTTLFLAPFSDCMTATNVSQFSVDCQDLSVATSAVPSVVPTGAPDPAGSTANGTSTGTSSDDTGLSGGAKAGIAVAAAVVGLGLIALLVFLVVRSNRRKRADMEARRAHEIDSQPAAPPYSELPQNEKKTATEMHAAIPQEIASSVMTPVEAPGDERWGPRQELPGDWVPTPVEGSHASHQPGDSNTMVSSEDTTVVGGEGKRNSKIGGVSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWK2</accession>
    <name>A0A1C1CWK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6603 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWK2"/>
    <dbReference type="STRING" id="86049.A0A1C1CWK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09415"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04192"/>
    <dbReference type="eggNOG" id="ENOG502R9QD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5352492at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046538">
        <property type="entry name" value="DUF6603"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20248">
        <property type="entry name" value="DUF6603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6603" evidence="2">
        <location>
            <begin position="1626"/>
            <end position="2143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1605"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="2482" mass="274007" checksum="2B211981A41FACAD" modified="2016-11-02" version="1">MSYYQFDSFHVNVGSGDGAIHILSSPLQNGGRKVERAFFIDGGRTTAKAYINLTIARIQENFFCPNPYDDGSFLMFDAFVITHWDGDHYDGVIAFLKDELVHVDNRQDPEAYYIRRAWYGWPTNPNDPKQPHTVIYTPWKWLGGNGFSVVGNNLARENLFGTGYIGTNLLVVRTNFENLLGRNFLAQDQQGGTSLDLNNMKTLPALLQMNPVENPVQGVGENFESWPAMYCIAAEGMPLTRKKLPLGHHTAKNMSSIVFILIWRIRPNPERYIISHYFAGDAPGNLELELKNFMDGWAPISMKLSHHGSASSNPASNFLAWNPTNIVVSAGVQYGHPRWEILFAMDAWFRHEQANNGGKARPFYPCQWPSYLVQNAADAYMHQGFSIAELKNNDPSGFVRFVMKNHEQMRDERIMSGQGLYLDNPVTMVDVRRTLFKDRYGYEAPDAEVKQWVSESIEIMMTNLSPLPRDGQIADEVCVGYKGYMSFFGLYYEEPVYETVPWSDVVAVQVTAIPETEKLGQIAIIGINGLGMLTDRRFGAVDTVAENSEVLLPATCSSALGLANLTGPGTAVAVSPYSFKGDDRPKAIDTSTGNPKWPAKSELGHLDEPRSRHMGQDARRTTTGLQDGKDDYSLEPWIEVRGAEDWSFLSSDSEGETDGDDESELFNRLSLNGRTQKLGVLAEPQLRAPVIYREVPMHITKAAVYLACEKVKFPEGSQGYILLKDQPIYGFTDTLHYRGFGLAEVPDKVHNTPLDPDDEVYHWLGTFCGWDTNQPVPNGFALSMCKVADWPIDPSKKEKQDFAMTVPYIDGQQLQFSTGTGAEYTFSKVEEGDKTDKSVTATSLRNMHISRRSLIFGLEDSAALLKTTLADIAKFIRLDLDRYPLLKFLGSQMKLTLDTKKDFHNALWFRPGLEYETILRLQFRMDMTTLNEWLHTFNANLSVDDVLLVARKRAAWMWKTKQDGASFNSSIACLCRMTISSSLQLTGVFELSQTAVMLTLTLDSSSGTAENKALRGRNGAVSSIIQWLTDKFNITKASELDELLKQAADSNSGALDNDSILPRRVQVVLDVDANGKISGVSAATIDIEVCLTVGRPEAAVLAQMPIVFLFSFGWNKTSGFYLKGKLWTVIPDTPFTPYDRALPGFEEYQLIKPVSPVDPQNQQRTLDLARLLSAKESDVQNFPAGIPNRINRCEIEISQKSIGFKGAVRCSPPEDGGQTTPPLISLDELELEASYTWGTKSPSDDGFNLRLAIAVNLYLGGKLDEKKDLDEQYNAATKLLGEVRYDKGAWSIEASVINLSFSHLINFWDTADRGPILDFLSQINIDFVTVKYEFGNKGKTAGLPSSLQILGQFTIADVAELTLDYSNPGGDRWTLTAGLGPSAKTKDAATVGKLLAGFMGDDVIALFPDAIKSAKIEGADGQKALRVICAKTKGVTIFACLVNVGKVSVWFLQLRQGDAAPKRLLKATVSKVSVEVPALHATLNSPWEDLFFVWVQDTTKREVGDHALPGITQQEYDSLAEVLKTQASIADQELLLFKPREKKQTNSSTFGLCTFDDPLIDKTTVIPAGYHLVVVAKDTTGKAGVVLDYLFKQVVKRTTRVDRLGLAELPPPDPSGSEKGTKAPYQAKLGPLSVSNIGLWFKDGMIGINLDATLLMGPIGLSLLGFSIGVPFSGKHSLDNPPSMSEVQWGLKGLIVALDRPPLTVAGGFMRDTSDPKVPIMYTGGLVVTFKPWSLEAMGAYATVKKTPTPSSQWITTIDMKPFNQRCLSSGHDTDELVEFGDAKEFTFAFIFIKLNGPLFSVGFADVAGLVGGFGMNSDILLPTVEQVVNFPFVKERDNTKQQSVVERMQNLMDGPWFTPAEGRYWAAAGLRVTAFQMIAANLVLVIQFGNGSFLVGLFGVATCDVPSLESPVKFAHVELGIVCTFDSNSGIFKLEAQLSPRSFILAPQCHLTGGMALFAWSKGDYSDPDPNQRVEAGDWVFTIGGYHRAFHPPRAYPRPPRLGISWSLDSSLSITGEAYFALTPKVLMGGGRIHAALSLGALYAYFDAFLDFLMNFEPFFFQLQARIAVGVRFTLDLWLVTIRINAEISASLDFRGPPFGGVVHVDFWVFGFDIKFGSPPSPPPPISLERFWAVVIKSGASGKSLLAAAPIPEVDGHGDINTTASADTAAILLTCETGLLPPLEQEQAKAEHLRSQDEDSGTWYVKGGKFSMLATFQFAVNSARLTEKRTILDQSGKEITEERASDAPIDNKYKAVYAKPMQLASTPLTSAVTISVKAPTPKGLATVHIMETWKDQRWKLGTRISPMPSSIWGKYDRNLDPSVVGGAIDSLLNGKDATVALVTGVTMGPPEPARAGDMINKFNVTRDHVSTVYEPQKPDWPLFIGVLEEQDKAWTPRGRSLKWDEVRDKWRSVGDETTTKAVDLWAKRLRFDRDSVEADQKDERLKGQFKPLRGVAPKRLLCKFDLLIPALPMIAVGGYHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWX2</accession>
    <name>A0A1C1CWX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dhdh</name>
        <name evidence="8" type="ORF">CLCR_10390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWX2"/>
    <dbReference type="STRING" id="86049.A0A1C1CWX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10390"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04297"/>
    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="47"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="162"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="377" mass="41737" checksum="570A34C859B4CAC6" modified="2016-11-02" version="1">MGNSLCVTFTELKVDRCTDQTDARPATGLISSWFVEDLVLDRPDAKANHVIQCIGSSSLEKGKTFAEKYCPKASPTVYGTYEEVYNDPNVDCVYVGTPHSFHKKNCLDAIAAGKNVLCEKAFTINAAEAREVFAAAEKKNVYVHEAMWLRHRPLVAELRKLLFEDNVIGDVFRMASDFSLLIDTPNLPDTSRYKDLKLGAGTLLDLGIYPLTWSFLALDPNTPEDSERPKILATQTHLHGVEVTSSVLVQYPSTGRQGVVTSTTMSGLRDPVVCRIQGTEGHVDVEGAAPALPLSFTVYRRKAGTKNDTKDDLESKKYDYPQIGRGFIYEADNTALDIAAGRKESAIMPWKETLRVMEIMDEIRKQGGTIYPQDSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX00</accession>
    <name>A0A1C1CX00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX00"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10326"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04250"/>
    <dbReference type="eggNOG" id="ENOG502SS12">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4926491at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="338" mass="38374" checksum="B8E63E2331854270" modified="2016-11-02" version="1">MSHQLPLQVRKDIRDVFEKDTSAVQGSLQQLARVIGYPVSCEPEWHMLWPELEPAYPDTAIFVPSVAKVIEAWSDSLVKRLEDDSFEAWTEVLLEKLSPVKRVKLSIQVADEARVKTIWVEDRCTFIVTLPKKASSHAWNSASSAFAEDLETLFEPSKSPDAVQSTQSHDDDDWAELTSNGDSKSLNIRTRPDDQPPQMLKDLPSLQTLPRPEILFQTTLPYLIHVVSHNTSKVTVSGTHEPSLRLLAEYLQRWIKTDPQDIRKIPYWRITMHESKLGLGMFHDSLTIEPFDHHQRNTVVNVSLILAFIQGILGYHPVPGPSSAAYWEFQRSVSFGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX05</accession>
    <name>A0A1C1CX05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-phosphogluconolactonase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX05"/>
    <dbReference type="STRING" id="86049.A0A1C1CX05"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10282"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04387"/>
    <dbReference type="eggNOG" id="ENOG502RVAR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="45335" checksum="42BF55923FFFB84C" modified="2016-11-02" version="1">MATSQQNGTSGAANGLYVALQSTGVVELAFDAQKGVKESLSVVSITTKAGFMPGWLTVSGDKVYTINRMGYPGSESDSGSVTAFQRATAGSSSATGETGLTLLDQTSSNGKGGVHCDVSPDGKVLAAANITASTLSIYPLSATGSIGKPTHVFDYNKSDPGPKEAHPHQALFDPSGKLLVVPLRTMDRVDIYSVNGPEQVTKVHSIPLPGSTGPRHAAFHPVSPSKAYLYLLSEKDNTVRVYAIGYPSPASPALTVEFKQVLSTMGKDVGRTPDEHKDLAGEIVVSNDGKFVYASNRNLTRSDFDTVAIYSVDSDPAHDDQHLTYLGAQELGGKHPRMIALSKDSANSWLAISHQLTQNIAVFERDPVTGFLKDLKGTISVRANQAHQPDIEKVTFAEDLSVRGNWTKEDLKQGKTEGPMCVQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXD5</accession>
    <name>A0A1C1CXD5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chalcone isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXD5"/>
    <dbReference type="STRING" id="86049.A0A1C1CXD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10317"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00109"/>
    <dbReference type="eggNOG" id="ENOG502RGD3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284:SF3">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16035">
        <property type="entry name" value="Chalcone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone isomerase" evidence="3">
        <location>
            <begin position="178"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="409" mass="44723" checksum="63B0CCC774BD4AF4" modified="2016-11-02" version="1">MKTSPLRMLVSRRVCTCNLSQLQAGHAPSSPHLIRLLSSSTKHNAQASFTSPVPGYGSSEMLRRKYQKSEPSELEKEKAERASTVKRMRYSGYGIAACTVAIFATIALYPSASAEQIIKQDAPPPPTPSTVLDETSAKEVEQVPTGTSTIPFFPRIIHLTSDAPPSTPGAANEGKTDEEYQLVGLGIRTVSMFSIQVYVVGLYIAVSDIAALQQRLINAVVPPSQSVATTLVPGEKDQLRQLLLDPTRGEDIWNEILKDGHLRMAFRIVPTRNTDFMHLRDGFVRGITARSAHFASDRNDSSFQDETFGAALNDFKSAFGGSARRKLPKGEILLLVRDGQGKMSVWEETSKTGDRVKMGDISDERVGRLLWLGYLAGKNVSSEPARQNVVEGCMEFVERPVGTVATQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY02</accession>
    <name>A0A1C1CY02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY02"/>
    <dbReference type="STRING" id="86049.A0A1C1CY02"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10524"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00323"/>
    <dbReference type="eggNOG" id="KOG4051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5595141at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="208" mass="22196" checksum="28E259EEEAEB8FEE" modified="2016-11-02" version="1">MPLSPVVSSSTRGGPSTAKSSSEPDDYWREFELPRDDFEELMWQKRFAPEGASAVGSSRPQSPAIATGPGTARRESTIADTDEPRSSPVSVSGGGPGRGRGRGRGGAGAGGRLSRLQNEVEAEGRRGSRRTSKAPSAAEQPEDEVMEDVDDEAEADEDESGAGEGEESEEPEAEPEQEDEEEAEIKRGGATKRGRGGRRGRGRRGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY72</accession>
    <name>A0A1C1CY72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY72"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11045"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="108" mass="12100" checksum="1314E827A9D1149B" modified="2016-11-02" version="1">MNHVEELQDVTQEKANANRSREVSQDDASPRHCLCSNRQNNRIGHAVIWPAGINEAVRVRGLRYSNCIVAPNEDDGIELEGKESRRAQGQNFDEIHAVHNLAKSGMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYR3</accession>
    <name>A0A1C1CYR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative cytomegalovirus gH-receptor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_09541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYR3"/>
    <dbReference type="STRING" id="86049.A0A1C1CYR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09541"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00569"/>
    <dbReference type="eggNOG" id="KOG2490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="864"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="434"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="933"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="974" mass="107669" checksum="441668D64B426BDF" modified="2016-11-02" version="1">MEGPTTTVPVLNGDHHNFRREPLAIHDPHDISASHTARTPKEADGVQVQDSNNGSSIVVEKVIPKGARVTDGAERLNGVEKDRNDVITEYVESHGAMALSDGMPETQQLGALGTSRTPIATRNGLRTTEIHTSQIVNEATTRSTDEGYKLSDEKLQRPVGSLGSLPPGAVGLQDKSPVSNEESSPQTAMPTGPGGLPASSNGDIFTSTPNIESLSLGASADPDVRRPRNLTIETGHKVVPSVLSHSARPGLSQRALSTPGSVRSPLSPQKGDRSGSRPTLRIPETAAKSEGTGGRRHSSSGRPLPSPMPTSIPLPPLSIPTYLQLELSSQRPSQLYIHRSANSDFPYESSRVKTERLLNFLVLPFYLERVLWFGTLACVDSWLYTFTILPLRLLKSIYILAKSWCTNFTGEVHFVSRFVYSGAGRMWRRRRSSVVPTTTRKPSAPDAAEHKLNQPVASHSRRPGRQHQRMKSIPSALLPDDKADMLKGLLIICTSLVLLRLDASRMYHWIRGQAAIKLYVIYNLLEVCDRLFSAIGQDVLECLFSKEALERKPDGHSKVLRPFWLFVLALIYTVIHSTALFYQVITLNVAVNSYSNALITLLMSNQFVEIKSTVFKKFEKENLFQLTCADVVERFQLWHMLVIIASRNIVETGGLSAGLTAFTKTTTSSPSAPLITNSSIPITTALPPRSVSSILPKSFTLVPAVVQTITTYAPAVSQVLGPFLAVLGSEMLVDWLKHAYINKFNNTRPAIYERFLDVLAKDYYTNAFGDQNLTKRLGLPVIPLSCLLIRASVQTYKMFMAAWIPSSPTSSTSLASIHEHYSSSARGATPMTTSTAISHTLDEIIAFIPTSLKTSSAVTHITTVLLFLLFFLVLLALKLVLGMLLLSFARSRYRSMKLRERNPIYHVDGGRRVGGWGVVEVDDDKRRWIYDDDPAGHKNLKEREEKDKKSKERGNGVESFEKVKRYEMVAKRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYY0</accession>
    <name>A0A1C1CYY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Quinate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">qutD</name>
        <name evidence="10" type="ORF">CLCR_09998</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09998"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00680"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF37">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="12"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT53747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="508" mass="56430" checksum="200E6DB289973AB6" modified="2016-11-02" version="1">MPLPPKWYQFLVGVFASLGSYLFGYDLGVIAEVVASNTFIEKFSPTDTESGLVVSMFTTGAFFGALLAGPCGDYLGRRWTITVGAVIFCLGGGLQTGAENISYLWSGRFLAGLGVGFLVMIVPLYQAELAHPSIRGRITALQQFMLGVGALVASWISWATYVHIKDNSAQWRVPLGLQIVPAIFLGLLIFLFPESPRWLMDHGKPDEALKTLAKLHAHGNEQDPWVMAEFEQVQASIAYEHEHEAKSYFELFRSKSAFRRLFLCCALQASIQMTGVSAIQYYSVTIYGQIGISGQDTLKYQGINSIIALVAQFCTILFIDRTGRRWPLIYGNLGNMVTFIIATILLAKFPPGVSTNTGAQWGFIVMTWLYNFSFSCTCGPLSWIIPAEVFDTTTRSKGVSIATMTSFAFNTMIGQVTPIAMSNIGYKFYFVFIICNFTNAIFFWLLLPETARRPLEEMNYLFNSAPWIVVGTTKDSYASHDLENRVNEIAHEVELKRSGSVLHEEKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ18</accession>
    <name>A0A1C1CZ18_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exo-beta--glucanase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ18"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10525"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00721"/>
    <dbReference type="eggNOG" id="ENOG502QTS6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651160" evidence="1">
        <location>
            <begin position="20"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="262" mass="28424" checksum="E6D55BCB43BC8648" modified="2016-11-02" version="1">MALSRLVLLALLPIASTLASPLIKRENDVVQGKLGTDGFWNDYDGGRNNYIQYTGDGSSKAGWPSDLSWISFNDMWVANQNIISRSCNRLYDVPNMTFLEIQDLYDSIKLVSQQTRVDHRFILAAVLQETKGCVRAKTSVSPDGTVRNPGILQSFRGNHTCNDDGKVQNPCPKAQILGMLQDGVAGTADGGHGYALDINAQATVDGVEYAQAYYRAARLYNSGAIDPSGDLEKGSATHCYASDIANRLTGWTDAPSACTFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ37</accession>
    <name>A0A1C1CZ37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="8">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">fdxr</name>
        <name evidence="13" type="ORF">CLCR_10059</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="8"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ37"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ37"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10059"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00647"/>
    <dbReference type="eggNOG" id="KOG1800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008860">
        <property type="term" value="F:ferredoxin-NAD+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="12">
        <location>
            <begin position="43"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="189"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="415"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT53708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="510" mass="55840" checksum="7647D6E7F7A3649E" modified="2016-11-02" version="1">MLIYLCLRLTSRARSPPPHITRLLSRSIRHAAAEVSSKGAGPAVAVIGSGPAGFYTAQKVMRKIAGARIDMYEQLPVPFGLVRFGVAPDHPEVKNVQDTFQDVAASPNFTFIGNVNLGHDLPLPLLGKHYDAIVFAYGASKDRKIGLDGEDKPHIYSARAFVGWYNGLPEYRNLDPDLQAGETAVVVGQGNVALDVARTLLSKIDVLRKTDITEYALEALAASKIRHVHVVGRRGPMQAAFTIKEVRELLHLEDVNFTPIPEALFPPDLSKLPRPKRRLMELLQKGSPAKENAAKSWSLEFLLAPKALQWSPTDPSKLEGVTFARTRLENVADPESKVSSTDETQLIPASTLFRSIGYKAEAIPGIADLGTDFDERTGTIRHDGCGRIVPLQETDTQGLKASLYCSGWVKRGPTGVIASTMTDAFQTADAIVEDWRKKTAQNESSSGPSLSQAGWKGVQADAEILKLPLRPVHWDDWENIDQLEKKIGTEKGKPREKFGSVKEMLEASGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZF1</accession>
    <name>A0A1C1CZF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_10101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZF1"/>
    <dbReference type="STRING" id="86049.A0A1C1CZF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10101"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00788"/>
    <dbReference type="eggNOG" id="ENOG502RY77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2406834at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651164" evidence="3">
        <location>
            <begin position="32"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="98"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="505" mass="56284" checksum="3A4A5A463C635F59" modified="2016-11-02" version="1">MEYANFCRCPGEVSLSFLALVFVILSISVNALDSDHPLLTDLGHAADPSANIKSLATKYRSAAMRCLSADQFLWRHNLHTVQALVLLIYAISHAHGPSWALLGTTFHICVSLGCHIDPSQLNLDPVRSEQRRRCWAGLMLLYTIQNTTLGNLAPMKLTESASVRLPADIDDEDISLGGILQRYAEGTDTRPPTKMSYILLKFKLYSLASDICQFARDGRDIGSLHELERRITAEENLHDARFADGQQLPIYHVAHQYILNNYIHYLRLILHRPYLHAFGSVPGRGVTQLPEQVLQSRAHCTTAAMVLLSNHEDLCCDVRFKPYRWFVYSLGSFQAFLAASTLRVLLASDDSLTDAHRAQFLGAIQKCQLRFENMAGRSDVCLKAARILRRLLQHLPTRPPPLVHQTSSASDESEMCSIKDGYTSINHSTPMTGFSQPGLPYNGPAVKADSSWFNCPPQMYELMSLPAEQWLGGASALAWDWSGWVEVDPYMNVPETLGVGPGVMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZK2</accession>
    <name>A0A1C1CZK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZK2"/>
    <dbReference type="STRING" id="86049.A0A1C1CZK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10836"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00806"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="160" mass="17939" checksum="4C14BE56A6FE2B3F" modified="2016-11-02" version="1">MSYVALPKIEAAVFSPTNSIPSSIIHLRTFSAGKRDDASRDRYPYFSPVLDVGVSRDRADRTASIPVAVRGGGRVSGRAQTAWLKRLPDNKPHYKSIFSVIICLFYLVGLFDLWTGVGTLLIDAIGTYVIIYVVDGSLMPWLVFMQVKLRDRNYRPRTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZR6</accession>
    <name>A0A1C1CZR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11117"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="73" mass="7878" checksum="7C107727A4B029E4" modified="2016-11-02" version="1">MYDNNGQTVGVLRNKSSTPTREVMPKPNFKSTQWACNDLGFKCITVACLEVTLVPSFAVSRLDVGSSPKAVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZX2</accession>
    <name>A0A1C1CZX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_09483</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZX2"/>
    <dbReference type="STRING" id="86049.A0A1C1CZX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09483"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00834"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000072">
        <property type="entry name" value="Cysteine proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="9">
        <location>
            <begin position="149"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="619"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="698"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="774"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1042"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="619"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="698"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="774"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="848"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="883"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="964"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="986"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1121"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT53920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1161" mass="130030" checksum="B9A1DA9124CF655F" modified="2016-11-02" version="1">MDDRRDNVGGGGRYYGPIPELNIPPPQPKMRRKIRRQPPQETVSQFWDRMAPRFPGKVFTVLPDNPYARKKAAKTPHGTVSGQRAAKSYEEARAECEKDVNRIIKECRRLNQKYRDLHFDIEWDLKSGQRNCLDGLSTPGDSMKPKGVKRITDIFEKPQFFINGPTAGDVRQGRDGDCYLMAALCGLGNMEGLIDKVCVKHDEDCQAVGVYGFVFFRGRTLPLICARDSIIKLKLLADGEWQHTIVDDKLYTRAPDYDEAQDERVVWDDINRVDSAEEYRKAHLTGSRALYFAQCSDENETWLPLLEKAYAKAHGDFASIDGGFTGEAIEDLTGGVTTEIYSTDILDRDAFWRDELMQVGQEFLFGCATGFYANWLDTSGAPREREGISEGHAYSIMDAKEINGQRLLKLRNPWGKKEWTGKWSDGSSEWTPEWMQLLDHKFGNDGIFWISYEDLLKKYQHFDRTRIFGPEWTVTQRWTSVSVSWSAEYHSTKFSLTLEEKTRVVIVLAQLDDTYFGGLEGGYGFDLQFRLESDNKEDENDYIVRSNGNYAMARSVSTDIELEAGTYSVLMKITATRHSDREHVEEVLPLYTATRREKLIQMGLSYDLAHAKGVHVETEAERKERKLREKNQRAKVQEKMKQHAKARAEKDWRRQKKEHELDKKRRARKNHWRQRKNRINGGFEEEIIVERRVERRHERRGTSDSLISEKPDTGIGAIDNPDGIVNRGAKERAGPTAEPNGAFQPEAKRTEDISNEKIVEPLEDVIKIADAETQAKTADSCSDAQAIQATKPATEAPDEESRPTPNAEANGSAVVTDVKPLSSAPPLSRPEHLANGVSVDGGDAGKLGQEERSTQEPHYERPRRSDTLDTTAAMMGIGSGADLTREPEDGDSDGGRIETPHRSGSPSNPAEDAKPDGDEEPASDADSFPPFDWDTELDYYSGPASSDSDDDDSLLSSALVERRTRPRYRPHYIRRVGRGRRSRSPPIGPIPPPGPRDFIEIGDKGGNAHDADDDGPEETWNAVCVVGLRVYSTLKGEGVKLKVVRPSGCSAEDEEGPRKAKENQGSSSRNGIGHVDGHGHGTAAGKDAILDPDDISKGAVAAEPESTGTVVEGEGQVNVIDKGDDLKLGSTKEIRWTGTREDNPGRTKGTRSRRERQLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZX9</accession>
    <name>A0A1C1CZX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00201"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02586"/>
    <dbReference type="eggNOG" id="ENOG502RED7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4468869at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="227" mass="25907" checksum="0AF66AE76863DB32" modified="2016-11-02" version="1">MADLGKRRRYQAVWASLICFLVFTHTNSGMLVDVGLLLAKHTEYEVTDILRAIATRIQSELDAAVRVLCVKMITNHAPTASKNPLLWWLTVLVRSAIDPLQEMDYISRGRFLMNILSMDLDLCGRLEAVQHYAKVLVLDKALELWRPCSDDWALQVNRDLVAANLDWLDDETDQRRSDDGDPRNCDSPAWPSMLENLNRWAMAFLSTRRDIDTSLGEVEKLLSAEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0G3</accession>
    <name>A0A1C1D0G3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetamidase/Formamidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0G3"/>
    <dbReference type="STRING" id="86049.A0A1C1D0G3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00289"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10171"/>
    <dbReference type="eggNOG" id="ENOG502SJT7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3335528at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.20">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="324" mass="34788" checksum="A2D395EFBE3AB042" modified="2016-11-02" version="1">MGSYSLHVNRHQSHLKWSKSIAPVLTVDSGVVVTFDTLDAGNGQVSTSTSAEDVSNFDIDLADPVYGPVYVNGAEPGDALEVEILDLTTADWGWTAVMPGFGLLADEFREPQIKIWQLPADKPYAVFKEGIRIPLRPFLGEMGVAPEADGDFSTIPPLNTGGNIDCRHLTVGSKLFLPVKTPGALFSCGDGHAAQGDGEVCGTAIETSMHATLRLTVRKNHDWVASPHYFSAPLAPIAGFEDRGSYAALGINSDLLEATRDAVRGIINYLTATRGLTRPEAYMLASTAVDLKLAEVVDMPNFGVAATLPLNIFHNEYKTVNCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0K2</accession>
    <name>A0A1C1D0K2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0K2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00264"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10173"/>
    <dbReference type="OrthoDB" id="4152393at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="470" mass="53013" checksum="804AA7C037635CEB" modified="2016-11-02" version="1">MAKDGAIRIQFVYERASHVLSEKDYRLQEAEALSHAAKVSHERRRQRKEPPLWKASPAYSDRDASPSPRSTPNSVMSFSEVHYLDPLYNVPHPRAGSFYRAIDIWFQWILPNAAPAFVLFNVCNVFESVGCQSEAAQHCIAALAYGCLELHRKETDSWEFDYSQEQLKHNALAISLLKRDIASKKTAADSPAAINTIFLLSFLAQFRGDHKESALHRKALRRLFDATAGPVDRAEFDRRYGGLLLHCWMDVLEGRPNVLEILPERQNPKMLMSAFNCSAASKNYDAAASLPVGFQVLVVKGVLSDESRRLLARFSHACQHGLGAVPKPEGQFPDYAVASPWLTAAEPSLEKCLQLALLCYAHMRWSIAPNYVAGILCHTISRTKLAQTLPWVPATNDRTITECLVWMWMVLVDSYRLEGSVLPGEGLSCLGEFKFHFPDWQNWTDIETCVLPKFFWREGDSIGIRKAWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0L9</accession>
    <name>A0A1C1D0L9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biotrophy-associated secreted protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0L9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00298"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10194"/>
    <dbReference type="eggNOG" id="ENOG502S1KA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2132010at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651230" evidence="2">
        <location>
            <begin position="26"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="325" mass="30875" checksum="7D621F26DF7E666E" modified="2016-11-02" version="1">MYTKTTFTVSQAILVLLSLTHHTLAAGTQFITGPCSSDADCASSCCGFNSGKCAGPVIAQERDGGCGFGDAQPNDIAAQAFFASQSGGMSPATAAADPAAMSTAAAGGSGSGSGSGSGSSNGNVGTGTQFITGACTSDADCASGCCGFNSGKCAGAIIAQERDGGCGFGDAQPNDNAARLLRGEQPTSPAGSDPSSSSSSSSSSSGSSSGSGTGSGSGTSTSSSSSSSSGGGSGSGAIDTSIPGSANVGKGDASQFITGQCFSDADCASGCCAFNTGKCAGAVIAQTRDGGCGFGDATPNDNAAKALTGGAKARKTRRAVREFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0M4</accession>
    <name>A0A1C1D0M4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_00276</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0M4"/>
    <dbReference type="STRING" id="86049.A0A1C1D0M4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00276"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10225"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="12">
        <location>
            <begin position="407"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT54297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="466" mass="52366" checksum="B7E15513937027C0" modified="2016-11-02" version="1">MYRLRTADKGRPLIISDKVITEYADCEVDTLHKKNLLSLGEDRYLTTLMTKHFPQMSYKFIPDAYALTAAPESWSVLLSQRRRWINSTVHNLAELVFLKDLCGFCCFSMRFVVFIDLFGTLILPATCAYLGYLIYRVASHTGQFPLISLVIIAAVYGLQAIIFIIKRQWQHVGWMIIYILAYPIYSFVLPVYSFWNQDNFSWGNTRIVIGEKGDKKVVAIQDEGFDPRSIPLQRWDDYAAANNLPGRRGNPGAYPEKGFEYGYTDDPAMMEMDDMHSTYSSVKPASTILAGFPQQQGPYMAPPRSATPMGMGMGMNNRASTMTGLTNFKDQPVSLHGRNMSMLSLGSQARLAKSPSPQPMPYQDHLNRSRSPYQGGLPHSASRPSLLNIASRPASTVMDFRTVPSAGPSDQDIIIAIRAVLMEVDLDKVTKKQVRALVEQRLQCEVPAGERRTFLDRAIDGELANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0N6</accession>
    <name>A0A1C1D0N6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RIB1</name>
        <name evidence="11" type="ORF">CLCR_00282</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0N6"/>
    <dbReference type="STRING" id="86049.A0A1C1D0N6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00282"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09465"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001591">
        <property type="entry name" value="PRK00393.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="245"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT54220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="434" mass="46926" checksum="9EFDC7DEFB1131FF" modified="2016-11-02" version="1">MARTTADYPSHASPVISPVARPSTAYLANWSDLDDGGAPTPGLPNNLVSPAFTPPATPGAGTPSRHLHVEPKSIPVDTSLDDPSVKQPRLVEKLPHVECLVRARIPTTSGAEMFLHLYQNDSDNKEHLAIVFGNGIRSRSLDAEKPGETEMDRMIRGAYVGRLRPGRTSSRIDPSEQNKRPHTKRLRSGSALKNVTTLPEDGVLEVPSEALTAAVQPPPAKDEQNAEQPANHQSPASLNTLLENTHITASSAGKAPLVRIHSECYTGETAWSARCDCGEQLDEAARLMSLPNSTGGVIVYLRQEGRGIGLASKLKAYNLQDLGNDTVEANLLLRHPADARTYGLATAILQDLGLGTDSDAEKPESERGIRLLTNNPDKVRAVEGPGKEVRVRERVPMIPIAWRTGGIKGVRGAEIEKYLETKIGRMGHMIHEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1J0</accession>
    <name>A0A1C1D1J0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Lysophospholipase</fullName>
            <ecNumber evidence="2 10">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">plb1</name>
        <name evidence="12" type="ORF">CLCR_00804</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 10"/>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1J0"/>
    <dbReference type="STRING" id="86049.A0A1C1D1J0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00804"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10108"/>
    <dbReference type="eggNOG" id="KOG1325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008448739" description="Lysophospholipase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="11">
        <location>
            <begin position="55"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT54548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="646" mass="69448" checksum="9A17D6777B3C3FB9" modified="2016-11-02" version="1">MKIPLVAAIASVLAAKATANAIPAENVYVDTLIAVENLRRSLPNSPQGYTPSFQNCPASRPVVRSAASLSPNETQWLQQRRNKTVTPLRNLLNRLDIEGFDAGQYIDTHSTNASALPNIGIAVSGGGWRALMNGAGAIKAFDSRTVNNTGEGKLGGLLQSATYLSGLSGGSWLVGSIYINNFTTIGALQAQSSGSVYEFGNSVFEGPEESGLQIFNTAEYYADLVSDVNGKADAGFDTSLTDLWGRALSYQLINATGGGPAYTWSSIGISQPFTSADTPYPIIIADSRAPGERLISANTTIFEFNPFEMGTWDPTAFGFVPLNHLGTNFTAGRVPSDDRCVVGFDNAGYLMGTSSTLFNQFILQLNNTDIPESLRNLLGGFLEGLDDNNNDIADYTPNPFFRYNPETNPGADSTRLTLVDGGEDLQNIPLHPLIQPTRNVDIIFAIDSSADTTYFWPNGTSLVATYERSISNIANGTAFPTVPDVNTFVNLGLNTRPTFFGCDASNFTGGNTVPPLVVYLPNSPYVSFSNISTFQFSTNNTQRDAIISNGFNVANMGNGTRDETWPTCVACAILSRSLDRTNTEVPQACTQCFDRFCWDGTVNATQPREYDPTPIFQAVSLESKGTRSLPRWAAIAAAAAFGYHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1J4</accession>
    <name>A0A1C1D1J4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">recQ</name>
        <name evidence="11" type="ORF">CLCR_02913</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1J4"/>
    <dbReference type="STRING" id="86049.A0A1C1D1J4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02913"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04720"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001389">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="36"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="270"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT54612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="505" mass="56933" checksum="3790750B8CA9B380" modified="2016-11-02" version="1">MRRASLRRTASITDLRFTLRRVFGKDAFRPVQEEVITAVVAGHDVFVCAATSFGKSLCYQLPAVVSLGVTVVISPLLALMENQVHAAKALGIAVEMINGRTALTDRRRIEADLLCGHPETKLLYVTPELCALDRFRNIIMQIHRQGQLVRVAIDEAHCISEWGHDFRPAYKDLIWLKTSLNCPSVPMMAVTATATKQVRDDIFKFLGLDHEKTKCFSTSTSRPNIHYEVQYLSESNPKTGDDDMFSHLLSKLEFMHRRRVTLLQHLRQRDPSAAVPPITGIVYVTMRATADTVASKLTGANITASAYHAGLDPNKREKIQRLFERHAKADPRLLQVEDDEGIAASFNIICATTAFGMGIDVSSIRFVIHYGLPKGMEAFAQESGRAGRDNKAAASIILYTREEATRCEYRMSCEAAKDRSKAKTESRFESLKRIVEFCENTSTCRHELVSRYFGDNKEAAECYYACDVCKEGPARLRQRKEKGLATEEQAIEFTQREPMRYDDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1N1</accession>
    <name>A0A1C1D1N1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1N1"/>
    <dbReference type="STRING" id="86049.A0A1C1D1N1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02898"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04688"/>
    <dbReference type="eggNOG" id="ENOG502SC6I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3905365at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="335"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="525" mass="58372" checksum="5BCE58DA8295A37A" modified="2016-11-02" version="1">MADSPASEPSQDQESGDETNAAQQAAAKAATVKDKECQYCHQHFTSSSLGRHLDQFISKKKPDGIHDVDEIRRLRGGITRRTARSSKKDKHNEHEDVRSSQGSPALGPGPQPGTLISSAIELNRIPPGGMHVRLNRLNWEATGVITDPATLDSPVVAAPPTPAVVSSPLGLKRSFSTYAQDLNPTNNAETTRALELALREVLDSLRAATKHASPKPSPFNFDVQSQTFPSLCLKVLPAPATLFQASPFSTPQSIPINPPGPDQLAPLRQKLSSAIDYWKWQALRLAQPTSSNIGEEQDFLTHSAKQWMESTLTHVDASYQNWMAQPLDIRNLLWQVELLRAYNSEQQKVQEMEEKLERLQQEADQLQQQVEYLSRCQWPREMALWPPERKTFGATMRDELRMINLNRGHAGSHRPGGADETVHAPIENVLTRMGDKWDFDKLVNKWKAHVKEDRNRRMPVAQSQQSMDGVVAGPPPPAAKVSELKKAQSEPGMNGLPNGLAPNSLEERRRSMRNQKGNISIISDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1X7</accession>
    <name>A0A1C1D1X7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1X7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03185"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04983"/>
    <dbReference type="OrthoDB" id="4161193at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="108" mass="12129" checksum="F0797C9C40AF7B10" modified="2016-11-02" version="1">MSVSGYSVQHDAEVQEYNKRRAAWKASEKKRKQEEKSLRAQAKAAREAALQQTKGLGGGEQKNMRPSIRWIRTSPREKSRPTLVEGKRLEEDSDGDSDEITLTDALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2C1</accession>
    <name>A0A1C1D2C1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxidase</fullName>
            <ecNumber evidence="5">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_02866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2C1"/>
    <dbReference type="STRING" id="86049.A0A1C1D2C1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02866"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05125"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF53">
        <property type="entry name" value="HEME PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008448741" description="Peroxidase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="6">
        <location>
            <begin position="127"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT55033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="555" mass="58372" checksum="6D65113F7B535964" modified="2016-11-02" version="1">MRRTNNLGLLALGLVSSIAGATAGLTWPSAYDDLEDLVYLTNGYNARGFPVILQPCTIAKEPGHSIAAGFVRTAFHDMAPFDVATGVGGTDASIGFELDSSIYPTNTGLAFNNTMHFYSQFFNSRTSMADLVNVGLYMAVRACGGPIVPVRAGRVDATGPGPVGVPEPTDPMPKMIGIFRRMGFSPEEMVFVTACGHSLGGVHSAEHPDIVPPNSTPLGVQDLDSTNATFDNSVVTEFLDGTTKNPLVVGANPAAYSDGRIFSLNNRQTVSALADPYAFANTCSGIFQKMVNTVPRTVELSDIITPYELKPTNLQLNVAADGQNLEFSGELRIHTNDLPSSSIASVQLIYKDRTGASDSAYTISATVAGDANGFDDTFTFYSFASTIPASTSISTFTVLVTLTSGGTQTFDNYGQGYAISDKIFAQTSYSSLSAVDGSGNQQLTVFAAARTGEACEPVNLSMELIKPITYNDLPTVSVVPQPMTSICAGQYYTFYSATFSVPAPGVNFTHYDVSATSDGAVVADSFKGLKSLPATAAAAPSCGGAWAKRAVNFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2N8</accession>
    <name>A0A1C1D2N8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arylsulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2N8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02854"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04989"/>
    <dbReference type="eggNOG" id="ENOG502QPU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="577" mass="64537" checksum="D378C21BC7D54349" modified="2016-11-02" version="1">MPLMGRLRFKAKSQPLLVRLLLYAILVAAGAGVLYLSVAYVAIPLLIVLSPTLHPTLYELGLYGGSPSQTYISNGLSSPRISTRKSDPQCDKAYTFLNFNGASMARSGPAILDPDNELVWKLETEGTTTNLKVQTYKGEQYVTYWTGMKGGTMGSGVYHMLDSSYDVKHTVSAVGLGGDLHEFLITKDDTALLTFYNVTPADLSSLGKTKTGWLIDSGFQEVDIATGELLFEWRASEHFQVNETFMTHPFGGYFKSIPFDFFHINSVDKDSKGNYLISSRHTHSVSCIGPDGQMLWILGGQRNQFQDLSGGEALTFRWQHDARWVDEEAGIITLFDNKEGGPLHIDGPYSRGMMLQLDVPNRTVTFLHSYISLHHTRAPSQGSTQYLPASRHVFVGFGHSPVLSEFTLNGTLLCETHYGAPWLHVFDTAVSYRAFKSANWVGTPRQPPVAKILDDTLYVSWNGATEVAAWVLQGASEHDEGFVDLDVVYKESYEETFELEQLSQYSWFRVAALDRNGQVLRSTDVIQRESSSSWWTFLLAVFCWGVLFRAAWVAYKWSSERGHTGKKGVSWVVWRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6H6</accession>
    <name>A0A1C1C6H6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1989 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6H6"/>
    <dbReference type="STRING" id="86049.A0A1C1C6H6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00682"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01056"/>
    <dbReference type="eggNOG" id="ENOG502QSJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527:SF0">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="54"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="302" mass="33918" checksum="5FFA1A07FB0986DB" modified="2016-11-02" version="1">MSSLLSNEERLRARKPLPTPYPAYLPTAESPLTVNNDLYTSIQQGQRELVDSFVLPIRSGRAWKAPAKSIIRISTPEGPQVGDLNIWNANNPRERFWASRTKQLHSSHVTTYDRLWSCLPYMRPLVTIIADSLSWYGVDETGGRVHDLLGTRCDPYINTVLSGPAASYDYHCHSNLTRAVLPFGLNESDVHDVINLFQVTGLDSKGRYFMNPSPAQPGDHIEFFAEQDLLMALSTCPGGDLSLWGFGSDSEKEMIKCCRPLKVEVFKLLDEDKVLGGKWKPAERPDYRGVHGMVVPEGEKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6V1</accession>
    <name>A0A1C1C6V1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6V1"/>
    <dbReference type="STRING" id="86049.A0A1C1C6V1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00722"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01129"/>
    <dbReference type="eggNOG" id="ENOG502S8N7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2937326at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="158" mass="17258" checksum="10DC69CFA8EF45C5" modified="2016-11-02" version="1">MAISALPTWPLILFGVLEPAALVWAYFITLSDPQQYYADQAPQGLLSNHVFTPQSLSLTLQLGNVFLLLAAMAVICCFTKHPEITRRYLIAVALADLGHIYSVYGALGDKVFWDLNQWNQMTASNVGVSVFLHINRLLTVTGLFGKLGAGTDASTKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C761</accession>
    <name>A0A1C1C761_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_06370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C761"/>
    <dbReference type="STRING" id="86049.A0A1C1C761"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06370"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07024"/>
    <dbReference type="eggNOG" id="ENOG502SDUV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF5">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="168" mass="19715" checksum="92553D1E8617194F" modified="2016-11-02" version="1">MEMAPSVVADVQPPTSSQPPTSRQNNLRNPLPLSPAQEQEVRRLYHERARRRCADVIKDFADCARGRTISVAWHCKDQHLAMNSCMIQYATKAEEDAAREEWFQGILARRRQKEEALVKVEERRREVIELTRRQEEKERIEAERKKKEMDDAKKLEGKEAKGGGWWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8I8</accession>
    <name>A0A1C1C8I8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8I8"/>
    <dbReference type="STRING" id="86049.A0A1C1C8I8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06038"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07501"/>
    <dbReference type="eggNOG" id="KOG2948">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="360" mass="39669" checksum="6DF529CB38B1C98E" modified="2016-11-02" version="1">MAAEIATKRLKANPPLIGTHNGHFHADEALAVYMLRLLPEYASAALVRTRDPAVLETCHTVVDVGGEYDALKNRYDHHQRSFDTAFPDHKTRLSSAGLVYMHFGKAIIAQHTKLPVDHPDVELLFRKLYDDFIEAVDANDNGISKYDGSKLQEAGIEQKFKDTGITLASLVNDLNHEDPLTLGAPSRATAEQPQAEEDYRFSQASTLMGTAFLRKLHGAATAWLPARAVVKEAFDLRSDAHPSGQLMALPRAGIPWKEHLYNIEEESKLPADKRILFVIYPEKEEPGSKWRIQAVSKDFSSFENRKSLPGPWRGVRDEELDAVLGDAVENGAVFVHASGFIGGHKTEAGVRAMAALALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8T0</accession>
    <name>A0A1C1C8T0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MYND-type zinc finger protein samB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">samB</name>
        <name evidence="2" type="ORF">CLCR_05674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8T0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05674"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07592"/>
    <dbReference type="eggNOG" id="ENOG502QTM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="607" mass="67578" checksum="6AB4C3BDAC662F49" modified="2016-11-02" version="1">MREVNFSIPNVNKASVHITTTLYDRRALDCTSTLPLINSLNHLAYLTTSSARIRDILTVDGGVERLVCILKEGRSKDEMHMWKWNLAFQCIVNIGVRGSENVRTRVVEADMVPVIATILWDYILVIEMEKAKADAEQEKRNGSKHSGSSRSSKLSRDLTHDSAARTSFFEHLHAAADNRSRRQAPPPSLELPQSFSQGFGGAETGPPDGGVLPPSVLTSPPERTVFPRRELHHHHHHSRGRESRGSNHGSLALQPPATAVPSMDTSDGFSLRPVREVDRLPSMLPPLNTGVTSHPDSPTTPSAPLHRGLLSPVGRRLRRPSIRHQNSTGDNDDMSMEDVAGADDELLDPEGAAEGRSRDQTRDPSPNEIDGRQPLTLAIPPPQTRDIDDVDIAQQTPITGGMGNPLGGTIHDTLGISPIPPPPATAASPAIPLNAYPNFFLRNATATASTTALMPRDEDVLMGLQLLAYISKYCYLRHYFQQTHLVPRLRIDREVEKIYGPVRGCAPLPEPTEDEDEEFLQPDDYNIFPLVEKFTVRHHSKDMQYWACVVMRNLCRKDDARGGIRQCANYKCGKWEEFTRQFAKCRRCRRTKYCSKVCGVSCSHWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9W9</accession>
    <name>A0A1C1C9W9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9W9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06376"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="73" mass="6826" checksum="589BF8756E6920E7" modified="2016-11-02" version="1">MGLASKLAAANAAYPGGPPAPGGAPGGPPGGGGGYPGQQQYQAYPGGPPASAPGATSRPVRVIPPPCAFSAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9X3</accession>
    <name>A0A1C1C9X3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha and gamma adaptin binding protein p34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9X3"/>
    <dbReference type="STRING" id="86049.A0A1C1C9X3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05819"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07965"/>
    <dbReference type="OrthoDB" id="10261384at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034627">
        <property type="entry name" value="Irc6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043:SF1">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="54411" checksum="2B2012736EF38DC6" modified="2016-11-02" version="1">MPSTTPSSQVKPSSLRLLILSPSTGPRFSPSTSASESASGSGTAIQSIPTPPLFPAFLEAITGSRPSADVTTFSGYTSHPPLRLTTKYYARDVGIWCDELPLRTARSRDAPPAQVSLPPSESDQLESDPRSKEGSQRQFSQGDNTSKGTGTGTGTDTDTNTDSITPEPTLQDWTLQILSPAAREVRAVIAGIVLLLPVSSTSTSAPVTSATRASGSASHELDQDHDWDAFIKFIQTAHTLREAIEDDSPGRDIASLVVLQQASAPPSSSSSSSSSSSSSATRRTSPQQDALLEQIEERCLSMGYLGWEFVAWDGREVQHNEADQDHDQDQAERNVYGEKTGLPRVLEVLESVDWSAEPDHGDDLDDFDFDDEEDDDDDDSITLPNIRAKASVTNSMSGFGGLDFELQREMMELKMSMLGMDEGEEDDEEEEDDDDNDNNAEDDSRGKNHGDNADVETQIERLPGLVERVVAIREAGQEMGKDERERFAKREIARIMSEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA49</accession>
    <name>A0A1C1CA49_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ria1</name>
        <name evidence="12" type="ORF">CLCR_05406</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA49"/>
    <dbReference type="STRING" id="86049.A0A1C1CA49"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05406"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07983"/>
    <dbReference type="eggNOG" id="KOG0467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000746">
        <property type="entry name" value="Ribosome assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="17"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="755"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1075"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1081"/>
            <end position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT45349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1094" mass="120970" checksum="1104868FF318E6A0" modified="2016-11-02" version="1">MPAIPPSRLVALQTKAENIRNICILAHVDHGKTSLSDSLIATNGIIAPKMAGKIRYLDSRPDEQLRGITMESSAISLYFSMMRRQKDDEEPKQEEYLINLIDSPGHIDFSSEVSTASRLCDAAVVLVDAVEGVCSQTVTVLRQVWIEKLKPLLVINKIDRLVTELKMTPAEAYSHLGRVLEGVNAVIGGFFQGERAQEDLEWREKLDQRRAAREQQKQDALNESATEADIDQSYEERDDEHLYFAPEKNNVIFGSAIDGWAFTVRQFAGIYEKKLGIRKSVLENVLWGDFYLDPKTKKVLGQKHLKGRNLKPIFVQLVLEPIWQAYDATVGINGDRGDPALLEKITKSLSINIPAHIARSRDTKVILQAVMSSWLPLSTALLVSVIEYLPSPPNAQASRFPEMIQDLVSSKNIDQSLKDSIINFNTSPSAPVVAYVSKMVAIPESELPSKRRKLGTTLTADEARDLARKKRAEIAKAQAEANGTSDMDSVTNGLSTTRIGEETEEGTAPEQPEDPEHLIGFARLYSGTLSVGDEVYVLPPKFNPAFPHASPQPRKVPITALYLLMGRSLEPLEKVPAGVVFGIEGLEGHILKTGTLCSQVEGAINLAGISSLSQPIVRVALEPTNPLDLNKMIKGLKLLEQSDPCAVYEQMESGEHVILTAGELHLERCLKDLRERYAKCDIQPGEPIVPYRETIVKAEEMEPPKNKDLPRGTALAVTASKMVSVRLRVRPLPQNVTEFLIKNGPSIRRLYAEKQAQEENESGTLNDANGVETDEAADLGNDTGGDHRSNLSLLQFRQQLQEVFDEVTEDKEVWAKVVSRICDFGPRRVGPNLFIDATGQHTCKRFLFEQHEIKENGAQSGTQGAGSADTTAPAQDFSDTIAYAFQLATSQGPLCREPMQGVAVFLEDIVQQSQAQESADSPAAAETGRLTGELITSVRETIRSAFLDWSPRILLAMYSCTIQATPEVLGRVYSVLTRRRGSILSEALLEGTPYFTISATLPVAESFGFSEEIRKRTSGLAQPMLKFTGFEMLDDVDPFWVPKTEEELEDLGVHGERENVAKRYVDGVRRRKGLLVKGPRGGRDAEKQKTLKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAC1</accession>
    <name>A0A1C1CAC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAC1"/>
    <dbReference type="STRING" id="86049.A0A1C1CAC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01644"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="247"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="330" mass="33770" checksum="FCBEF3A168D77D14" modified="2016-11-02" version="1">METGIPPPPAQAHPLTPSPAQAHPLAPSPAQAHPLAPSPAQAHPLAPSPAQAHPLAPSPAPTHPLAPSPAQHPQPSPTHSTGPVGRPSTSSTSSQGSFPVGRPSPAPIAPQGTTPIGRPSTSSSRAPTAPGTQPTSDSALVAEFKADPMKVLQRFPDTAALVAEIMRANPELPIGQAERAIVDTLEGFLKGQNAQATLNVRRTAVKLAKLALWISIINVVASGGTATFSAVSTSQQAKQSTSVQGQLTTTQTELAAAKQNLADLQHNVDVLTTTVAELLLEIGRIAEATRGPSKFTPSGGQMFNPSVGQKGSNHSAPVSGQKPARLDDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAE9</accession>
    <name>A0A1C1CAE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DSC E3 ubiquitin ligase complex subunit A</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Defective for SREBP cleavage protein A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase dscA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CLCR_05533</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic component of the DSC E3 ubiquitin ligase complex which is required for the srbA transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. Required for growth during hypoxia and triazole drug susceptibility, as well as for virulence in a murine model of invasive pulmonary aspergillosis (IPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the DSC E3 ubiquitin ligase complex composed of dscA, dscB, dscC and dscD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAE9"/>
    <dbReference type="STRING" id="86049.A0A1C1CAE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05533"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08059"/>
    <dbReference type="eggNOG" id="KOG0828">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000626">
        <property type="entry name" value="Transmembrane ubiquitin ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
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            <begin position="1"/>
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    <sequence length="747" mass="82923" checksum="2F37150AC463C77C" modified="2016-11-02" version="1">MEGPRVVLLIVLLLFIFLTPEQPARRFRQFEADSIEEQHQAEADVLANSSYGQLNPKTHSWLNLTGFRDADGYQWESLALAQQLSRSQFETNWKGIDPTADLPIYKRVTGELRGQFLRNVIPGVSPVLNLTAIDPKKDYLSGWFERNVTEKKGEVSLSLYDSQGRLSHEAAAIKAELALSTDSSPGNGWQAKLHGVHFPSGMIIMSTSSSKFDALPALPHFAPDAASFNLSVPVMNETVHSNWEKVFDDGADGLAFAPQCELVIWMQPIPYRFRDADNLKATDFIHRVEQELIRPEGAPIGQPPLLAYSAVIFSPDCGYILLSPTISGPKIEAYWTLAQRLLFAFVLSIGLQIALLKRQMEKAATPSTRSRIAYQSIVIAALGDGLLLFALIALLMVDASAFLMVAAAAYLSCIHVAFLEVKFVFDIWTVQVGDPQRAEQTRQQRTAPSTTSAPPAAPATTPAPTSTDGTVGLPLPVTASRPGGATPVILPSDQDSPVPAEVASPRASFAAIYSRFYFSLVLLMFFSLWAMSWPRSLRSGYANLLVFCYFSLWWPQIYRNTMRNCRKALSWEYVVGTSILRAVPILYWYFADRNILSIDTSPTTALVLLAWLWLQVAILLSQHLLGPRLLVRDSWCPPAYDYHPLLREDDVEATGMSIGLLASASEAKDKDDRTRKVFDCAICMNEIDVPVLSKADHALGRGTGTAWLEQRNYMVTPCRHIFHADCLEGWMNLRLVCPVCREALPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAK1</accession>
    <name>A0A1C1CAK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">adk1</name>
        <name evidence="6" type="synonym">ADK1</name>
        <name evidence="9" type="ORF">CLCR_01646</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAK1"/>
    <dbReference type="STRING" id="86049.A0A1C1CAK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01646"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03410"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="8">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="170"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="51"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
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        <location>
            <position position="77"/>
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        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
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    </feature>
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        <location>
            <begin position="98"/>
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        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
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    </feature>
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        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>AMP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT45499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="275" mass="30118" checksum="E57E8A14B046C479" modified="2016-11-02" version="1">MAPITDQHVDDLKDLVHKLEARVWSLERRLEGEKKPSITESMRMILIGPPGAGKGTQAPRIKEKYCVCHLATGDMLRAQVAKKTPLGKEAKKIMDQGGLVSDDIMINMIKNELDTNRECANGASFILDGFPRTVAQAEGLDSMLEAESKPLKHAVELQIDDGLLVSRITGRLIHPASGRTYHKVFNPPKEAMKDDVTGEPLIQRTDDNADTLKKRLGTYHAQTAPVVAYYKNKGIWSGVDASQDPEHVWRSILGVFGDSKATASGGSILGKLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAY7</accession>
    <name>A0A1C1CAY7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_01533</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAY7"/>
    <dbReference type="STRING" id="86049.A0A1C1CAY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01533"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03521"/>
    <dbReference type="eggNOG" id="KOG4534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3361892at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032931">
        <property type="term" value="F:histone H3K56 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016849">
        <property type="entry name" value="Rtt109"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF2">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE RTT109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51728">
        <property type="entry name" value="RTT109_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="304"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT45612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="521" mass="56791" checksum="494A2F4338B19248" modified="2016-11-02" version="1">MLAKSSLPLRLAAVLPSGVSLRAYHVSTTPTSTSALFAPSPGNEERTSCESHFLAVSTPGNGDSREVLIYAIEVLIFTTKSLTTLFVSKADSSGFSTRLDNPKGSPSVVAVLTAAFVEYLLEPRLARSRVVLSLFARAQRQYLFPGSSENVGKHVLDDRHLIKWWCRIFDGILRHPRDNSTATAHLLVPGCDKGETKAFYPPSTRADPPARPKWINSYPVDLMVTNTSLPPRHLVPRLPDDPKARFLDDLDGEFVDERGNWRSVKDLTQFWEFMSYRQECSAGRLVGFLWLVFSHDQAKYAASSELQQSEHTQRPSKPMAQPSLLTPGNSQQMEHGAPEFGPQDSSTLNPLPTLHSPPPSSPLQQEPEPIPLQDFQDRVDAPAAPPLAEGSSLPVVDQTRGEIVFDAAQYQTLMDYLLQTDFTGEEAAVETSRSWIDKALELSRATSFGQPVLGCATPGLAPSAQAVEASSAPINVLTGVRKKRKVDVVEDASVRSNGVEIAGAAAINTLAAGLVRKKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBA1</accession>
    <name>A0A1C1CBA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBA1"/>
    <dbReference type="STRING" id="86049.A0A1C1CBA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01642"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03722"/>
    <dbReference type="eggNOG" id="ENOG502S039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058268">
        <property type="entry name" value="DUF7962"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25907">
        <property type="entry name" value="DUF7962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7962" evidence="2">
        <location>
            <begin position="110"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="333" mass="38808" checksum="DCB30CE0A3735CA5" modified="2016-11-02" version="1">MPPLIILFTYDISVFGRKTDWVLNLKGLKYFRCIVLNRLPRPVLQQLGVQYRRIPILAIGRDIYCDTRLIIDKLEELFPENRISSTSPFEKGLEHLFENWLIDGGPFWRTAGLIPPTAEVMHDKEWLQDRTNMTGRKFDIETLKQGRAESLSHVRMYFNQMEHELLADGRQYLLATKEPTLADVHAIWTFDWALQEKGHMFEYLEKEVIGEDQFPRTFAYVNRFRRSMAKKEEQNGIPEALSSTDAVKRILASDFFEKEGTIDPRDPLKLRKGQLVEIWPVESGFTHHDKGELVSIGVKEVVISSRPNVGEGRLRLHFPRVNFRIKPVEESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC24</accession>
    <name>A0A1C1CC24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CLCR_00359</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Noorani M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC24"/>
    <dbReference type="STRING" id="86049.A0A1C1CC24"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00359"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09995"/>
    <dbReference type="eggNOG" id="KOG0735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000011">
        <property type="entry name" value="Peroxisome biogenesis protein peroxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="544"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="870"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="221"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="705"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1066"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1157"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="724"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="736"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT46017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1262" mass="135635" checksum="C6E7C3D7B7D69C17" modified="2016-11-02" version="1">MAPPVRAEVALTSLQNCLVNLPPGLIALISNTNIPAQNVVVELQYRSQTLSSGAVSSGNSAGFQRCAYVGWTGMPSRTRPASLLNNDRTRPGSREQDVQTVEIDATFAKVLGLAEGQKIGILIHLDPPVAHSINIEPLAPADWEVIELHATFLELNLLSQIRALPNPAYTSRATTQTETAHPLTLHLSPTSTANIVVTSLVPPIPNTIPFAKIAPDAEVIVAPKTRPKSSRSDRRDARSTASRRSGKSGVSSARKAAPTKPALFMRAIDRSVADGFFDDASNATRTNQLCVWIGSDVIESESLKAATWVNVTIVKPNGMRAQLDTAQLNRLKEEEGSEVGRPASKIVAQVLPWPTPVDGNHAVLSSSLCRILGAEGLVGVIVRIQAANPPLPRYSIKKFQFYPFLPLNSKKKDGLQFGGDSQSAKRALADRLRLTFAGDDDLLAGALTDGMVLPASGDASSATSFDGGILRFRRPAEVDEDPDNKTLWVVAQEQDHEFEIKADVARPVELTTLFPTFAHGIPTKLPTLIGADGILQQCMSNLTLCSSVLLTGGVGSGKTSLAHCISQRLREDYVFNVTFFDCQKLVTDETRVSTVKETLTRLFMSASWCARLGGQSVVVLDDLDKICPSETELEVGNDNARSRQITEVLCATVRQYCSIHSGVALLATAQSKDSLNSIIIGGHIVGDIISIKAPTKEIRRDILASLTSDGSSQTQHKHTRDPSDTQSMSENSWMDPSNPSSRPTSSASSPTSDGFRVSPSLDFLDVAGKTDGYMPADLVLLLARARNETLTRMITSNDDSSDTQPTLTRADFDAALRNFTPSSLRNVTLTHSTTTFSSIGGLHSTRNTLLETLLYPTKYAPIFARSPLRLRSGLLLYGYPGCGKTLLASAVAGECNLNFISVKGPEILNKYIGASEKSVRDLFERAQAAKPCVLFFDEFDSIAPKRGHDSTGVTDRVVNQMLTQMDGAEGLDGVYVLAATSRPDLIDPALLRPGRLDKSLLCDMPDMNDRLDILKAVSTKLRLTPEVENRLLSVAQRTEGFSGADLQALMYNAHLEAIHDLLGDRTSGTGTGTGTSSHAAHNKDTSLPNGTGPGKRRKKHASHAKHDFIQFLYSPEEDALAKKSLGTGASAAESKAAVAAKLEDLKMMRKREKAALRNSFARRSASGSRAGTGLGLGLGPDAEGAAEEHASASASADADTKDEKVVISWLHVEKSLASTRSSISPDERRRLAAIYREFVVARNGEMPSGQGGREVGGRTSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC45</accession>
    <name>A0A1C1CC45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major Facilitator Superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_00412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC45"/>
    <dbReference type="STRING" id="86049.A0A1C1CC45"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00412"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06725"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF187">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT46048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="516" mass="56073" checksum="4B455CF00F7E3765" modified="2016-11-02" version="1">MADEPSTAASAKDAPEAKTTDLVQDTERSVAPSLSSAEHNNEKGGAITNAALDLDRIGETQGYLLDEAAVREKYNIAPDVALKTSKDGKVLIPQPTNDPEDPLNWTRWKKAAILLVIGVNAATSDYSAATGASALLPQAEQWHISPNTVNHATAGMTFCLGIGALAAVVLSAWIGRLPVLFWFGCLSAGTAAWSAAAKSFESYMASRILNGFFVIAGAGGGLMWIKDVWFFHEHARKINIWSTAIILSPFLGPQFMAAILSTSTWRTGMWLNFGIIALGLVLTIALGDETFYPRHLMPDRIPKRQNRLLRLIGVEQYKQKYTTNTLLEAGSRLCFDFRNLAALYVAPVVGAVLGLIVGHFLFDLIEKLWARYHNGVIAPENRLVIIWLVLPLKLIGYNLIGATLQNARTWSFYVLAVGWALHNFATIITTAAVGAYLLDAYPEAAGESAALINFARTLGGFIVGYIQIDWASSAGTQTAYGIQTGIMGAAFFIVVFLQFFGARLRHAQGPLKFKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC46</accession>
    <name>A0A1C1CC46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC46"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00510"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10320"/>
    <dbReference type="eggNOG" id="ENOG502RKZB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5596743at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058645">
        <property type="entry name" value="NTF2-like_dom_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26534">
        <property type="entry name" value="NTF2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650709" description="NTF2-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="NTF2-like" evidence="2">
        <location>
            <begin position="34"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="222" mass="23466" checksum="059E15FCE9336042" modified="2016-11-02" version="1">MRLLKVAASLALASVVAAVPDLYKVRRDASSNSTCVSQGDAENIVAKFITVMEHTDVHAANETVQELLSDSFTETSDSINTIAGNALGSITFPNKVAYIASILNAPAPRNITTLKLMPAGCTNILWYWKMQVGTDLVPVQGFNLMEVGENNKLLGQLIEFNSIAWAVNTGFTVKNRVGQNVPVPGQISASATALASSAASVSATSVLPLLLTAVVSYWGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC77</accession>
    <name>A0A1C1CC77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC77"/>
    <dbReference type="STRING" id="86049.A0A1C1CC77"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01287"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09400"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="251" mass="27293" checksum="9AF486977EA5060D" modified="2016-11-02" version="1">MSSKKAQVRRGEMMRCVDVDEKLTLLSNDRSADNAKSRTVNVYGLNNSSFGKDGQDHNLDSFFKYSQTYSEEDKKAFLPVPEDLTWVYVSDPNAEDPNAASPPSHAQTASDTYQQVAAHTLEALSTAAADHTTSYPPQGTAYYTAANPQSEPHPEYGFMQGGPPGAANGDTPGNIGYFLGNSASRNQTDTSLIDPNLESTVNSAAERTDEEPDRRDGKSHVGGEAQKDHEENLAEESRLAITLKNFNELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCI5</accession>
    <name>A0A1C1CCI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NDT80</name>
        <name evidence="5" type="ORF">CLCR_01121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCI5"/>
    <dbReference type="STRING" id="86049.A0A1C1CCI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01121"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09336"/>
    <dbReference type="eggNOG" id="ENOG502SAHY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4117572at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1390:FF:000007">
        <property type="entry name" value="p53-like transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF1">
        <property type="entry name" value="PROTEIN PACG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="91"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="91"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="443"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="612" mass="66470" checksum="3420A8113572A3A5" modified="2016-11-02" version="1">MASTMDGYDPLAAPYFPSPIPSYGGGGLQNLDYMSVPSVMDLQEQYSNFDSEPYMSGDELGFAPSNSLQHPAMLKRYSSGFEDPFAESTMSQFDQGPADGLPDSPSIDRDSKYLSFSMPQYNFTLLDDSFRRSSVNITAQLHGMFFLAESQWPATADTPPPPPELTCYRRNLFQITGSVTLPRNLRYVFTDDGSRIPIYELELAVSATESVEGNSVKIISVPWKTPASGEAPKPEDKVEREPPTIPLDKMSGQDLDTDFTTFPIQWKRLQFRIATANNGRRKELQQHFTLHLKIMASLSTGGKISIAEAHSGAVIVRGRSPRNFAARKDLPLSSSSTARKHLPAASRASNSATSVPQVTSAPKIKTPSEEIPQMVAGYDSVDTKPGDADGATWVSQGVHDPLVTPYSTSMSRPAVPAFPDGTPEIGTPGTFPFTFPQEMAQGSRPMSLHFGSDDEGGSPHPPQQNSRPSSRPPTSNPSPSLLNRGAVGTYTGNTSTSPGHITNQAGPRPRLQSHQVSMTSVPSSMSTMNGTGPQPPMSQRPELLPTKSGLPYGAEGDSVDQLYEYFPLGLDDWQPPVDAVFRPHVVHHSGPLPPDPRSPGRHTSKRYFSEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCK1</accession>
    <name>A0A1C1CCK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAGA-associated factor 73</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sgf73</name>
        <name evidence="3" type="ORF">CLCR_01216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCK1"/>
    <dbReference type="STRING" id="86049.A0A1C1CCK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01216"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09261"/>
    <dbReference type="eggNOG" id="KOG4140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="185"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="383" mass="41327" checksum="AC59CC04002A8E02" modified="2016-11-02" version="1">MATDGSPASSPSLLSATTYKPSKAIKKAPKAQLKKISVKKEAQVNGIKHGGDAPSPELPKFEGETMANFPAGHPESLETLVCKHCKKSILQRTAKDHIALCLKSKQDKARKKKEAREAAQRAKERAEKVDDDDDDDDDIRGPGRKDAANGGDDDGTKKGKKRKAEGDEDKEPKKKKRREDPKSKAAKPKGPVDVEKQCGVTLPNGVQCARSLTCKSHSMGAKRAVPGRSLPYDMLLAAYQKKNQARQQKAAIDANAPALFEDDMDPTLNGPVDSDEEKDSVMTAISRSLARPQPLVTRELFPIRRKYPLIRLKEMLSNAMSGNRNGTSIFSVPSESARSAVPQSGINETFPSSTVSASPALTGIGMAQPGLKVPLRKSSIDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCV8</accession>
    <name>A0A1C1CCV8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_01056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCV8"/>
    <dbReference type="STRING" id="86049.A0A1C1CCV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01056"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09198"/>
    <dbReference type="eggNOG" id="KOG2250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="700"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1069" mass="120281" checksum="34E6D63EF1816D44" modified="2016-11-02" version="1">MDHLSANGDQPLNPAKHKILDQVVRTPGRQPSPQPTLLGVPGASQSNQSLHRILSDHSSGYVAPKFEGKKAQMEEVMDLIEDKGFLPSDFIASETEWFYNSLGIDDMYFSTETVEAVASNILSLYAAKLAAYARDDKKLEIRLAKEASDHAVYIDTSTPGVSVIEGPRYEQRIDEKYIDGSTPARSYRVESFRSNNALPDNPDQSLRCYFIYQCQFSNPSTGPDETDIEVIGEKRFLQKATQKTKEIYQEIITYAVSRTGPVIEMFDMEGTREKRLVIAYRQGSAMGVFSALSDLYHYYGVTSSRKYVEQFSNGITVISLYLKPASGDIAKSRFPPIEAAIHQIIKEVSLLFCIPQNKLQGQFASGNLSLQESIYAHCVHVFVQQFLNRLGSEYTSLVAALKGDTNANAELLSKIKKRLRTETFTSEYILEIINKYPDLIRNLYLSFASAHYVQTRGEQDDFIPTLSYLRLDVQNVIDDATLSELISKTTQNQHDEMVMQYFLTFNRAVLKTNFYTPTKVALSFRLKPSVDFLPEHEYPQPLYGMFLVIGSEFRGFHLRFRDIARGGIRIVKSRNKELYAINARTQFDENYNLANTQQRKNKDIPEGGSKGVILLDYQHQDKARVAFEKYIDSIMDLLLPPTSPGIKDPIVDLHGQEEILFMGPDENTADLVDWATEHARARGAPWWKSFFTGKSPKLGGIPHDAYGMTTLSVREYVLGIYRKLNLDPSKIRKLQTGGPDGDLGSNEILLGNEKYTAIVDGSGVLVDPAGLDHAELVRLAKKRVMIAEYDTSKLSPQGYRVLVDETNVTLPSGEKVNNGMTFRNTFHLRDGSQYDLFVPCGGRPESIDLSTTSKLISDGKCTIPYIVEGANLFITQDAKLRLEKAGCIIYKDASANKGGVTSSSLEVLASLSFDDKGFIENMCVGADGTVPEFYKTYVKEVQETIKRNARLEFEAIWRENEATGIPRSTLSDQLSLAITKLDEDLQNFKELWDNKTLRMQVFKEALPQTLQQKIGLDKILQRVPDKYLKSIFGSYLASRFVYEYGSTPSQFAFFDFMSKRLATAVTNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDA5</accession>
    <name>A0A1C1CDA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sphingomyelinase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01949"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01244"/>
    <dbReference type="eggNOG" id="ENOG502QTTH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5819478at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851:SF1">
        <property type="entry name" value="GLYCO_TRANS_2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="68"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="467" mass="52078" checksum="54C6AD336B0FE878" modified="2016-11-02" version="1">MEERDPKGSKVAQSLITLFSGKFRDMQYTVHPAGLPGEAPGKSSNVSWAAKQIERKYLNNPNWSSVLVTVMDSDTHLLSQYFETVVAHHLRHRKYRGMTDMSLYMPPIVFDRNAHLVPQLVRVADLMWAGAGLSCFTSKPTPTTIAIPTAVYTVPLPLICLAGGWDTGSEAIGEDMHMMLKCYFATNGRLTIRPIASPASQCNVATGKPGIRGWLADHSARYAQGLRHMWGCLDTGYAVRRWCKISLDPKAQEHATPGSESSSSSSVGCDPERPRHVEICLQLSQHALHGPKLRRFTWRNLILFSRLFEAHFLPIHLFLVLLASAIYTALPYPLTSCASLTVAMDLTSYLRAASFFLMTIYFVIFYEAYHQACIEARANEMKKAGLYEELADEFSHRKRLSFVAIMDYLLFPVAGTLFGSVPLLQAIVSHFWTEKLVYLVSAKPLKAIAAGVLDTRANESDAMLRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDB7</accession>
    <name>A0A1C1CDB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02129"/>
    <dbReference type="OrthoDB" id="4117869at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="195" mass="22125" checksum="D80F34092672CB71" modified="2016-11-02" version="1">MPSSLRMLVGLTPPDLAHSPSQREPCTKTITIEQMILVLQWSHGESDNKAYEVLSTVYPLDGMETFAHVPETLSNPQSCSTELLRDTQTYMRDHQLCSWDIKSVYEMDATDAMSAEESDETHLVLLGRSKPCNCHKMWRPRHAVNIVRIATSHSHKERKAMMATALDARTTTRSARCSDKPLFSLARPFPHVVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDU6</accession>
    <name>A0A1C1CDU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GrpB domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02070"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01414"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01415"/>
    <dbReference type="eggNOG" id="ENOG502T584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="GRPB DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G01530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822:SF1">
        <property type="entry name" value="GRPB FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26103" checksum="92BF35E88E04B6A8" modified="2016-11-02" version="1">MPPQNVECETHIQDLKHQQESSPLDISLVGMATTMPVISVVDYDPAWPDHFKQIAEKLSYYLNICGVEYLTIEHVGSTAVAGLIAKPIIDIIIEVPDACNAELAKEALVHEPPPEAHYKCIGDGGIRGRLSMKFQGQRVVPSQSVQNPEGRLIMRCHRALRDTLRMPEHESLKKAYGQTKIELASSSQHSLEYGQKKNPIIRRLLRAAGWTDADIDKKERLDYRAPRDDLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE87</accession>
    <name>A0A1C1CE87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE87"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02176"/>
    <dbReference type="OrthoDB" id="5377009at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="103" mass="11277" checksum="8642B2EAE3705107" modified="2016-11-02" version="1">MSRRARHSSSPLYGSVRSGQGYQRRPSFSHGYSDWGRSSRQAQAPVPERDSPPQSCLSSISSRASMFINYIQSKSVVVVTKKIDSALGKVGAMEEVETKVGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE97</accession>
    <name>A0A1C1CE97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Fe superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE97"/>
    <dbReference type="STRING" id="86049.A0A1C1CE97"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02016"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01564"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="147"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="269"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="342" mass="38968" checksum="335406E1CB995584" modified="2016-11-02" version="1">MITRPVTRPQSLLRALVKQTQPRHTSASFTLTPFQRRCKHGVPIWPNQARQELFARHGVPGFLSAETYQETYVRYSQHLADQLNELTLGTVDEDTGTHALHVKYAHRSDKAYLYNISAMLTFTRFFWEECLTETKDPAARKPGLLTMKSIEHTFGNVETLREEMLETADAMFGNGFVWLMKGESGQDLKILRTYNAGSPYPEAAPRRDDTDMATFGPGSSISDQLSGRSGLGLSGPEERDIAVGSSTAGSFGDFSANRNRYHAGLLPMQPILCVNVWEHQWMRDYGLLGKRQYLTAWWDRIDWQKVENAHNLITTENLSSWQRKQPAYSAHRYESAMDIFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEI7</accession>
    <name>A0A1C1CEI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02610"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02527"/>
    <dbReference type="OrthoDB" id="4159202at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650763" description="GPI anchored protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="24753" checksum="2C97ECDC868A4066" modified="2016-11-02" version="1">MKNALSSALPAAAAAVALLSGQAHAQDDSSTVINVFWITETTLSLNSINQYPLAGSIVTAMTREDKSPGKMRLTLSRQDSSSTVVALECVGSSIDTIVCPSAGQTITYGSTTWVASETTGNLGVTLQCSIAQNSKSAVCTGQIEAPDQIFTDVNINSSEASELLTATNVDMLSTAYSGTISSTDFTFLPVTVTAGQDKLAGASSAADSSSSSSSGGDGNGAGSVKSNLGLSGLIAGFLGLVMMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF11</accession>
    <name>A0A1C1CF11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">sck1</name>
        <name evidence="14" type="ORF">CLCR_02263</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF11"/>
    <dbReference type="STRING" id="86049.A0A1C1CF11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02263"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02360"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904828">
        <property type="term" value="P:positive regulation of hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045945">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901494">
        <property type="term" value="P:regulation of cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047484">
        <property type="term" value="P:regulation of response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090153">
        <property type="term" value="P:regulation of sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000116">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="499"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="761"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="192"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="378"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="844"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="844"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT47061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="886" mass="98578" checksum="268E6CDF6A0FECEB" modified="2016-11-02" version="1">MSCADPPSSSARHEHRHEDFHDLVGSNSPTPSGVETPRPDLHDKRLPGIMHSYFGQVGRDPSQITPSWSSQAGTLPEHQASEQNASSSQKEEEGKGKSRRVSTASIGSMVMVEREQLSVPTPPPDEPHPESLRLMPETDPLRLPPTPISSAASMVNRDGEAAENGGSLLDGGLASITQALRNFVLPKSTYSVKDRRHQSLPVSSVTRSTVAAAHISNPASSTHSSRTQSPRSPSPSHAKPPSSEKLRESDELTSNVAPALREKSTPPHTPRALSQEDYRRADTRSPLSSTSTASSDRHTQIEQKRPLKDQLPTGSTPRGKLSIKIAEGRNLKPSYDPYVVCQFEWNEYVSKGARHDKMDVDEDDRKGAVSQLSSVPIRRTDSDMGKPMAIPMKSRQSSTNGNGEERGLSKVTDPQWDHEAMFDVVSDQSELDVTVYDRQSETFLGHVRLCLKLTEQNPTLEGFFRLEPRSAEDQDISGEIHIQMHFQKVEKKHFGPNDFQILKLIGKGTFGQVYQVRKKDTGRIYAMKVLSKKVIIQKKEIQHTIGERNILVRTATTESPFIVGLKFSFQTPSDLYLVTDFMSGGELFWHLQKEGRFKEGRAKFYIAELILALKHLHQSDIVYRDLKPENILLDANGHIALCDFGLSKANLTQDDTTNTFCGTTEYLAPEVLLDEQGYTKMVDFWSLGVLVFEMCCGWSPFYAEDTQQMYKNIAFGKVRFPRDALSTEGRNFVKGLLNRNPRHRLGANGDAEELMAHPFFADVDWDALGKKNLVPPFKPKLTSVADTSNFDPEFTNALNTSSSLNARAAALAAGATAESTPLSPTMQNAFQGFTFVDESTMEERFGGRDSQYDDRVDDNSLSRSRTKEHRMSGVQKTGDDGFFFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFA1</accession>
    <name>A0A1C1CFA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative integral membrane protein Pth11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_02370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02370"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02253"/>
    <dbReference type="eggNOG" id="ENOG502RYRX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5398233at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF19">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="45"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="563" mass="62787" checksum="A52CBB3FB45E8758" modified="2016-11-02" version="1">MAVIDTLERRIYHDEPPAYQSRIAMNPTLIVSWWCTLFALTAILIRVFGRWVRTERLFREDWIMFYSIIPLMIRMALVHVVLIWGTNNTKTEGLTALQIHHHEIGSRLVLAARIFYAAYIWIAKLAVLEFLKRIIGKSWAKSYEVGLRYIYGFLAATFIAVVVGTLAECQPFSHYWQVVPDPGAHCREGLVQLIVMGVCDIVSDVVLIVFPIPLVWQSSMRFSKKISLILLFLLSIILVAITAYRVPSTISRHSSQQYRSLLASLEILAAAGVSNAIVIGSFIRDRGVKKAKFRAASMDDGSSLGRTNTQTRAVSMTHHHWGSDEDLARGVGVALPAPLRRGVYLDQIRPAEVAVSNPAPKALSVPVDSNEQIRHAPFKSKWNFAEASRMRRKPSLDTLSSTSTDDIKMRNLRLHTDEPLHGEGGDEYTEPDTPSRMGFFDVGGLVDAPPNESPISRSRQASIQETSRRLSQSQPQRSSSKAFLADIGGLLTRPLRIREEDEMQSAGTGSPRKGSSPSRSPIRSEKRKISRGSRLPSTQEDVLPHRPSGPDEMFLSDAGGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFC5</accession>
    <name>A0A1C1CFC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear segregation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFC5"/>
    <dbReference type="STRING" id="86049.A0A1C1CFC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02382"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02259"/>
    <dbReference type="eggNOG" id="ENOG502QRKP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2195113at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="56957" checksum="3AE7A035F6F0768D" modified="2016-11-02" version="1">MADTQAAAATDVGHKRPEKPDEAKFKADLAKAEKEHEAAQARFNAIRSKLDSARPGKSTPANDRFKELVDEQKSIRQKQQEHKSAKAGQQEKFNQNDALIKKLIAEQKDARTRVGFKSPEEIDSKIDNLQKQVDSGTMKLVDEKKALNEISQLRRNKKGFAGLDELQKKIDEKKAENAELKKTFDNPESRALSQKYEDNQKELDDIKAAREDTNKNFDTLKAERDKLYEEQQTTYQAIRKVKDDYYAQRKAYKEFEDLIWQQKRERQKAEKDAYEKDRRRRIAEQKLEEASEPAFLDQIRTAEGLIRHFDPTYTTDEGDKGPGQFAATAQRTIDEAGFKGMKVVKKEDEDFFVGSGGKKKGKSKKGAAAPAESGKLNMNIGIIEELAKVGVDPPSTQADVPGVVEKLKEKLAAWKRDQDAETKKNIEKAKKEIEKLEQEAAEASNAASASSSGRQNRAKKVSAKDALVNGPVSAESEQVQEKDGVADATKELAEAKLEDKENTPAETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFM8</accession>
    <name>A0A1C1CFM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA replication protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MCM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFM8"/>
    <dbReference type="STRING" id="86049.A0A1C1CFM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02296"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02146"/>
    <dbReference type="eggNOG" id="KOG3056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273123at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger Mcm10/DnaG-type" evidence="3">
        <location>
            <begin position="485"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="754" mass="82207" checksum="D823A3C4E1D6AD27" modified="2016-11-02" version="1">MSSGGPWPPVSPHAALLSSPSGRKKYEAYKNDISSMPRSATTPSLVDRLRAARTNNDFPPQHQSPEDDEDEETLQLKLAAIEAKLKLKKLQKDKARAATPGRDSSIPGSAHEPPAPQVEVKASPTKRIQATLPKSPSRVLLGIDKGIRGADVSLKRASTVTGNRARINSSTAIADRPTSRSSAFNSARSATSSRTATSSECKKTFSERMTEARERETTIEQCRATTIQNRRRGFVLDQDELDSYRTAAAETRGQGASKSPTRQYFEYSRDQVLTAAAEAHSGTRHLKKSRTMPDLRASPSKDTGQPPRHEGDANLYEDFSGLHLTSRVLPHSFLRRTLPSETFTIYRIPDLLKNVKSPDYELPETVCDYVVFAVIASKSSPMDHKKIPNQRDPDKSTVGTRDWEKQWDDGSHNSRRFMAITLTDLAWTIDLYLFGTALPRYHRLTPGTVVAILNPGIMPPKPGKSDTGAFSLSLSDDSDTVLEIGHARDLGYCKTLKKDGKECGSWVNTAKTDICEWHLNAEIQRTKAGRMGVNTGSNGFGRRENRPMTRNEDRAHKGLLNKDGRRFDRETGAHYYIATTGPKGGGGSGGGGGAAGADDPFIQAVEGELSRPSDRNARLRRHLAAQAKEREIAEKLGSREHGGFGFDSAGAEYLRRKAKQRGEGAKNKGIGDDSLDDGSSKGSAAISKAILSNGSTTKENRKRTAADVRLSPVKKTRFVTAKGIREAGRDSLGAPGHPMAAHGSDSEDDELEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFT4</accession>
    <name>A0A1C1CFT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 15">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SEC11</name>
        <name evidence="17" type="ORF">CLCR_02629</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S26B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 15"/>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFT4"/>
    <dbReference type="STRING" id="86049.A0A1C1CFT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02629"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02115"/>
    <dbReference type="eggNOG" id="KOG3342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S24/S26A/S26B/S26C" evidence="16">
        <location>
            <begin position="39"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT47321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="188" mass="20635" checksum="70E28E93922F811D" modified="2016-11-02" version="1">MLSSLSPYLSNPRQSLSQVLNFALVLSTAFMLWKSLSVIADSPSPIVVVLSGSMEPAFQRGDLLFLWNRDKTAEVGEIVVYNVKGKDIPIVHRVVRSHVPAIPVEADISGTLAPASPKLLTKGDNNIADDTELYARGQSYLDRKEDIIGSVRGYVPAVGYVTIMLSEHPWLKTVMLGIMGLMVILQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG79</accession>
    <name>A0A1C1CG79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG79"/>
    <dbReference type="STRING" id="86049.A0A1C1CG79"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03272"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01865"/>
    <dbReference type="OrthoDB" id="4159667at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1133" mass="125319" checksum="11F44A4EA68F6FDE" modified="2016-11-02" version="1">MPKKGTPMKPEATPTRIMTRPSRLRTPRASANPATSSNPLPTVEEASDTITSSPTPVTAKPKPQTPAKPKTPAKSKTPATPKATTKKGAQRSNSSTAAPPEVVEVFDDDNAQEAGGGSPERGIVVSSTDSSPLSSPDSVTPPPDGSVKTPKPVKGRPAAFEDKPYKDADVSNDEPAPSPTAKAVAGRKRKTVQFADRSYTPGEESSDDGKIPRPKGSSRKRKFPRDEDKGSEGDDEEQEGEDHDVDEDYDYDYLYFLHDLNRSTEAAALEEELIQEAAPQMSISRDSELQASSSLATGQTLPAISGLDTVPSVEFPFEPLLQSGSSSGSQGSKRHSPKRQRTHSSHAASPSNKETADVGTDEGNMNDPTDPITAAKALFLTVQKAPRPLDLGEISALFMVLQEKISVFCKSHFNFDLTPEQEEEWPMHLLDTKYKALFEVTQWIADGSSCGWRNFFTKKENRRHLVHGIVSEYFQQHIFKHTAFGIREDMIDDLEDIDREYLRYDAFVRNKKKAAYMENSRFDDEYFPTPGDHPPHPEYPPNHQYHHDMDLAARRLATTMMQVLEPLLPPPCFDPLVRPWRRSASQRNQGALLRNDIWFELVDLIRKAVSLHHCIRFAGSTGLVVRIAPHVAKGSMFTVDDADRNICVNAEELNSSASRPQGPDARLRVKMTCFGRVEAVMPRGLDLEQMEKEQNAAQAAGYILTREEAERKLFPRLPYELQETEAGRNAVAHLDPVPGAEWNTALYRSNLENHVDQRFSRETTPTLKSEVISHPFVTIYPRVAPSNLYCEWVTDESSQDQRGQTLWEAVQEARKEKLMFRLRENAWKTIGDPLLLQWALFCGVACSVGIYGTRQLARMLETPRSQEVSTDVQTGANNALSAFSAMGVGATSYLSGLLTSPTRTSSTTLRATRIHLWEWTRFPPLTTTRDTITSTVIGTPITRTITVERKSILDTVFETYDPLTSVVTGDTTGMTTPIDIEKGTTTTTTTTMDVDEDKETTTPGDVDEATTVTTPMDMDMGTDEATPDVAESSTTQTPHSTASDVLLESLRAAGILTARGPGQTATRKEYVFRSTVDKDSEEFTRIQRIVRERMRAEGKLVENVQPAPAGPEPQPKPESTLTASGERVRSKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGL3</accession>
    <name>A0A1C1CGL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADPH-dependent 1-acyldihydroxyacetone phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ayr1</name>
        <name evidence="5" type="ORF">CLCR_03629</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGL3"/>
    <dbReference type="STRING" id="86049.A0A1C1CGL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03629"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10395"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF3">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE SRDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT47649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="305" mass="33105" checksum="CF6EE910D04C6474" modified="2016-11-02" version="1">MEKRPVRTVLVTGCSDGGLGAALAVAFHKHRWYRVIATARNPEKMTHLRSLGIETVQLDVLSEESISACVEKVSALTGATLDILVNNAGAGYNMPILDASLEQTKKQFELNVFSVIRVTQAFFPLLRASSAETKMIVNNTSCAPMLAFPFLGPYTASKAALSTVTETLRLEMQPFDINVVDLKTAAVKSRFFDNVGTNDAVVLPDSSPYAAGKDLVETFMQNGPPAKLMDADAWAKNVVVDLSRRGGKGAPDQIWRGAGATSAWFAATFIPVGWLDGTVKKYSGLKEVERRIRAGEKEKMTMMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGW1</accession>
    <name>A0A1C1CGW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication checkpoint mediator MRC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_03261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGW1"/>
    <dbReference type="STRING" id="86049.A0A1C1CGW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03261"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04587"/>
    <dbReference type="eggNOG" id="ENOG502QSP5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2130597at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024146">
        <property type="entry name" value="Claspin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018564">
        <property type="entry name" value="Repl_chkpnt_MRC1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396:SF10">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09444">
        <property type="entry name" value="MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication checkpoint mediator MRC1" evidence="5">
        <location>
            <begin position="863"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="501"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="679"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="814"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="855"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="939"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="994"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1133"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="521"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="855"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="871"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="888"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="994"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1011"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1029"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1147"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT47755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1324" mass="145619" checksum="37A0F3683579926A" modified="2016-11-02" version="1">MASSPVSPSIVGSPRSTTSILTPTRKVQALLAQFSDSESDNNAPVLPENAQETAVSQSHGVAEGVRPTGSPDDSKDEDILAPRRLTVPRQIITATPDRSPHHDRNNALESVLGRETGKDDKLFSNSEDDETWGNRHTTDLEGSNSGSRSPSPLFFPSPDGHKSKFLALVEKHRKQRQEKEALEAEKRALQLQSLKASKQGQRKPRGSSPADDTGEDSDVSEETGANRLSKQARPTRKASKKALEEMNRETQRISRNMQLAHQARTKKKISKDSLLARFNFPVAASKTERDHELSATSSSRAPSENEAEKRNDTPPTSPPADLVSPKLYKGKERACSLEPLEQAVPTHLRTMPGSNEIGEQPLAPSLKPLKEPGKFKISSFQAIESDDDDSGSDLEVITSRADKRKYAVFEHLRTRKAKEAPSHIALRSLANLIKDDRKRSGSAAEVEAHLRRLAREQAQQEKQHRLDELMAKGVVIQTAEEREREQQEVEDLLERARQEAAEIQKREKAAAKKEGNYTKDDLDDEEESDDEDFAVEDDDGDNEDSAEDDDVDGGDSEDEKPDEIEGAGQDAGSCLDNEAEESDSAESSSAESPAEMDNEASDDATEDLPPVNLVPRKSRLNRVVSDDEEGHEDQLPSPELPAPAKTPQTLTRSARKQIPGLQMSDDLPIGLTQAFDATMADSQSQESPFNKDHDSLRMSADLPSPNIAMVPKLYRLDSIDVITDSQPASQTQPLNVNLSFSQSDIVPQSPAIRSAADGMDMTPSQPQFEPTQDGGYVLSPFMGNRFATETPRHPLPHSSVDTIVLANDLQDSPIMQRKSRLRRGRATMNDSDDEAAEGKDSSAFVVMQRAAAKQSREAFDKQRSRAREAVDDAAEESEDEYAGLGGASDDEINDEENEDDRRMIDEDTQVGVGDEAKLAKLFADRERQQDEAAVSKLLKDITTGALRRKRGNDDLDLSDEEDALMRRREAKRREFAKMRRELLKDEAVGKIAEDKKKEAFLRSIEDRPNSDDDDDFEGPETQPEEDSQGTDSQNIQSMQRAEDNTLQQSSDTANQPLAATAASKLNRAVHTGRRNGIHINRRPGTLAEIRESVSFLIEEPDSQAGTVDLGLSDSEDDAEAYVDLDRHLQAAEADENAADANDLGDFIVDDDDDDDDGQAEEETMFKKPALPTSHSRAPFSDRRTKERVNVVNRLSMLRQQSSSDSSGSTKMAFYTSTSSTNSSFSKVPTLLRRATTNSSLGSMAGRDENVSATGVVTNKTERGKASDEKTFVRKGTGGRRNAVNYRPTVREEKMSQRAGVAKQAAAKAKKGGFLGVLFNGGSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH08</accession>
    <name>A0A1C1CH08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_03621</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH08"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03621"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04586"/>
    <dbReference type="eggNOG" id="ENOG502S8GR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1907495at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="13">
        <location>
            <begin position="207"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="110"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT47756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="319" mass="36132" checksum="1760EC7B3C077EEB" modified="2016-11-02" version="1">MPDIELLREEWKTLYSETLPKLAKARDPSQSKWPVTLNHCFARIILDNAIGDGQQQWDKILPKPAVRNMDEHQLQKAITLGLKIMAGDVDLCQLDEISLRCRGKNQAKYSLPTAKPAPQQEKQETSSTGATKRAFDDGKEASVPLPRKNRKTEQKQSTLDLWQPQVSEQSRHATSEKRSEMNTQKLDDEELEQILRRVRSHPSLTPYRKRLYTVLLSVPRGRYTTYAAISEYLKSSARAVGNGMRNNPFAPEVPCHRVLAADGSIGGFHGDWGKDGKYAAKKIELLRGEGVRFDGRGKVSGEPFRKFHDFQEVALERPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHV3</accession>
    <name>A0A1C1CHV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sister chromatid cohesion protein Ctf8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_04406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHV3"/>
    <dbReference type="STRING" id="86049.A0A1C1CHV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04406"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08266"/>
    <dbReference type="eggNOG" id="KOG4487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="156" mass="17275" checksum="CAA7927A07D61482" modified="2016-11-02" version="1">MPAIELLIPSSRTARTGTNSLPPLLQTPSGLAVVEIQGTIHGPFQDPTPEDEDQVPTTRQIGRLEFPLYNPDASNDDGKWMKKVYLYVGKHQRLTGEVKKLGKPLAVIQKVDHSSGDHRDADSDLNLGEPNQELLEIVEIIKFKVLFSTRPEPVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHW9</accession>
    <name>A0A1C1CHW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04382"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="182" mass="20219" checksum="1AFE60C3DFFA5862" modified="2016-11-02" version="1">MSTGTEDRLLRNLISFVVIIAIVFLLIWLKRKRERHVRVDGLSRDRNAIRVAPVGYTCEDLIIRPLPPAYEPRGRAQNGIHPRMSGLTPRALRSKRPRSFHTYPGPAGEDTPSNIDDGQSSSPDTLTLVGGDHAGCVIRANTANENIQDDNHFLSWNTSSSASSTLPPYLQSDPHGPPKYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI64</accession>
    <name>A0A1C1CI64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative formaldehyde dehydrogenase AdhA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">adhA</name>
        <name evidence="7" type="ORF">CLCR_04248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI64"/>
    <dbReference type="STRING" id="86049.A0A1C1CI64"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04248"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08361"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="13"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="328" mass="35686" checksum="05A04277136CE40C" modified="2016-11-02" version="1">MVDFTVFKGGKEGIVKATSHREVGPREVLVKITHSGLCGTDIHYKEQDMGLGHEGAGTVENVGKEVTLLKEGDRVGWGYLHDACGHCKQCLRGAETFCAERKMYGSADLDQGSMGSYAVWKEDFLFKIPDQISLENAAPLMCGGATVFNALQFHGVKSIDRVGVIGVGGLGHLAIQFAAAMGCEVVVFSSTDSKKEEAMKLGAREFVATKGQKELKVSKPIDHLLVTSASQPDWNLYLPIMAPSGTIYPLTVSNEDLKMPYMGIILSGLRIQGSLVAAREIHREMLEFAATHDIKPIIQKFPLDEEGIKDAFHTLEEGGMRYRGVLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIV8</accession>
    <name>A0A1C1CIV8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_04276</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04276"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08523"/>
    <dbReference type="eggNOG" id="ENOG502S1TN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2435509at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650839" description="DUF7137 domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="4">
        <location>
            <begin position="112"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT48392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="284" mass="29775" checksum="828EA715C746C671" modified="2016-11-02" version="1">MKGFGLFPTFAALLLLLTALSSAWPWPETLDNKIDALLVPRQENDNNDDNASPTEDNASSTPASQSASGSASRSTITSPATLSASGSGSGGSASGNATRTTSTKTTPIDPRLPPGGVALITPALIDGPQYYKVGDFVTFAWNYTSLSVTPTAIDVLASCAQNAQTYTLTSNMSVEETGAFTWDTGEMYATATNPFPVASYTLIIHDSSQDVTDVPSAGFLAAYQQYIFGMYTPQAYTPLNEFKCATCSGALSVHEKQALGVILTASAITVMSFAWFANGFGVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ35</accession>
    <name>A0A1C1CJ35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcriptional activator protein acu-15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_03852</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ35"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ35"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03852"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08575"/>
    <dbReference type="eggNOG" id="ENOG502QTKQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15485">
        <property type="entry name" value="ZIP_Cat8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000007">
        <property type="entry name" value="C6 transcription factor FacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF12">
        <property type="entry name" value="REGULATORY PROTEIN CAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="603"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="724"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="604"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT48451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="862" mass="94731" checksum="26181C409260B49A" modified="2016-11-02" version="1">MPGILPMKMIRVGSSAASRIAQACDRCRSKKIRCDGVRPCCTQCANVGFECKTSDKLSRRAFPRGYTESLEDRVRGLEAEVRELKDLLDEKDEKIDMLSRIHSFSPPSRKCSSSLSPSQAVQVKEEVESAREEVLHVEIPAPVQPKVSSTGSSTTLSFIEAFDQKVQEAGRQTTGVSLSGLQKAVQPTRRTFTQGPKVPPRILSDQYINLFFQEWQPLMPVLHRPTFLHVYEQYLANPESGHWQDNKQAYAQLFLIFEISALSDISTPKTSTPSYETQWRKALYSTSSNAALATLQCHILAQICYILRADYTHLARHRGIAITMCHELGLHQGHKYHSLSPLEAESKKKVFWCQYVLDKFTSAATGTPVLLRDGDITTDYPADVDDENLSTQGFSPTLPGELTKISSALALFRVSRILSKALDTLYPAKASYQLSLTKLHALSDELDQWSEDLPDHLRLRFCNDKPATNLISCRSPLLSLAYFYTRSLIHRPLLCHGSGSASSAAGILLAAAGKHVLQILDLLEERHMHYTFPLSKTDLLLNAGLAILWQTLDLEDDSKLVKDNHKSLTMAVGMLHTENVVIATEFQQVAACFTPGEARPAVVPSTTEPASAATPNVTPTMPAPVDSKSKSARKQLQAIASRWSSFSSSKGKPEDVPRRATVPQTGPTSVPQVHRAGSSVSLSSTRSAPVMMQMSTPSPRQVHAPNPLGTPTINLDYFTMGDDFGDSQTRASSSTMLPPRKQDTTPTMADNSGWEHFLDGLDPNSVAVFPEMSTSGQTLYQVPSNEWAPDSWQLSGMDLPTKAPVPKSLLSFSEESLTSGDDFLFSTAGSHSGSIGAADCLELPETYRGITIPVDDEFDFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ64</accession>
    <name>A0A1C1CJ64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="3">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CLCR_04036</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ64"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ64"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04036"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08630"/>
    <dbReference type="eggNOG" id="KOG3051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="14">
        <location>
            <begin position="64"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="290"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="495"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT48506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="547" mass="58709" checksum="45354E9632FB5FF5" modified="2016-11-02" version="1">MATTVDGVINDRVHLSSLPYSGCDTRIVSLVDINIPDQATEEEYRAIYTRYIQKSSLGSRASNASRLRDAVESIRYGIAPPVAFPTETVYGLGADATNEAAVSGIFAAKGRPSDNPLIVHIASVPHLERITGEPLPDVYEPVARRFWPGPLTILLPVPASGIFAKNVHPAQNTIGFRIPSSKYARFFIAAADRPIAGPSANSSGKPSPTTAAHVLHDLRGKINFILDGEGCDVGVESTVVDGLHDPPLILRPGGVGLEEFRALGREVGGEVGDKWARTTIGYKPSVHHTVETASNTSGSPSVAASTTSRSGGATASEELHANHTNGGSNGIASYQEDVNGAPRAPGMKYKHYAPRGRLVLFSRHAYQAGRVQEKLDQLAGAEKHQPVKVGIISCHWPPFAGLKDISSTIDPTRITEISKPKEGGQKKPDPILHSAYADITSIAPLRVRDQDVTLYNVQLGTEISSLAHSLFGVLRLFDELECSYIFAEMVQHSGPSPLREQRSTSAVTSGKFAEGGTDRSGSRQLRRDLEDAVIDRIEKAAAERVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJF7</accession>
    <name>A0A1C1CJF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJF7"/>
    <dbReference type="STRING" id="86049.A0A1C1CJF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05017"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03244"/>
    <dbReference type="eggNOG" id="ENOG502T7Y4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4143634at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="281" mass="30829" checksum="6B18898C5F4A0254" modified="2016-11-02" version="1">MPVTPAKAVNNSSVSRRSASNPSSKTAEVGHEPAHGLSSDGHWHEEANVGEHYETNLEDNQKKLKAFFDQVSKTNPWPGRFVKTVRSRQEAVLKKVEEIREKSVSDKKEFDAEMAPLLSAALGGLTDEPSDSASFSFPMQVRYLGAETQPYCEAMCGLLEQSGALVLAYDELAGRPTHKSRLDLIEASFKDDREATESTVAAGKKVAAFQIERLLTDRYNEVRTPHDLTAEEEHQGKVLLSHGTHENPQSKPTPGWGNVAVDTERAVGRLCFAGEVDDGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJZ3</accession>
    <name>A0A1C1CJZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05130"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03068"/>
    <dbReference type="OrthoDB" id="4152819at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="247" mass="27723" checksum="200FFC2419D9E330" modified="2016-11-02" version="1">MDDLNRSDRHQLVGNASSNAGSTPSIRPSSKPGQTRRQAYELSSISRLKIQKEASKTSPRLYKLVAHAAMFDNATRFILDHIDGSNVELDLSDSVAIEGLLDEKEHGCGHIAHPEDHEQNEVETIQSSFEVKNYTSFNGYAHLKPKEGCAIVVTEALADEVDDTCEDTADESNTDSDDDYDHFDDREIWSDAPLDGDWRKMQSGWDFWDASSNLVRDSRNDDLLLWSQQPRVLSTKQAESLFLEAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL71</accession>
    <name>A0A1C1CL71_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL71"/>
    <dbReference type="STRING" id="86049.A0A1C1CL71"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04745"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02684"/>
    <dbReference type="eggNOG" id="KOG3968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF5">
        <property type="entry name" value="CHLOROHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="64"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="333"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="524" mass="56994" checksum="97B77BA98629AC2F" modified="2016-11-02" version="1">MTTEPPNSSILLRGGTVLTHDKTDHVIVLRDTDVLVHNGIIERVGENIDPPSSSTEVIDCKGKIVSPGFLDTHHHLWQTQLKGRHAEKGLSHTCIRPESDGAVALGNMMSYAYKPEDMYWGQLSGCLEAIHAGTTTVLDHAHCAYTPDHATSALQATLDSGIRAIFGYTVPTRVAQWDQSQCVPEPDPMPEWAVQQLGDLLEKHNSAASLVEIGLGFDLWFLPKDMVLGTFQTLRQKGLRLVTSHVGRNAFMGLHSHVQLLQSYDLLRSPYPPSESSTNMPYLLLSHCNGISHEDMSMLATTGTPISSTPGTESQMGMGFPVGLDPALKSRETAHVSLGVDCHTNDPSSILLQARMLLQLTRVEKNAKIVAPGNYPSENVTGTSEEAFNLATIRGARCLGLGDAIGSIEVGKKADLVVFDAAGSVGMLSAVEYDPVVAIVRFSEAADIEHVIVNGVLKKRGGKLVATDVSLDKMGPMEWKETAEQVRRSQREIQQRIDGLSLQRARETLLAMFHTDSSRLVDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL75</accession>
    <name>A0A1C1CL75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL75"/>
    <dbReference type="STRING" id="86049.A0A1C1CL75"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04944"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02670"/>
    <dbReference type="eggNOG" id="ENOG502SNDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5373017at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="392" mass="42745" checksum="7AA8D0E652D2FE66" modified="2016-11-02" version="1">MSDPTFSDDTQLIAGLIQVATALEDEQSRDLSALGKRKRDESFIEQGHASHGDGFDAAPQTSHPPLQNSAAVLFREPSSKSKKHTRPPLGKVFSSLELAPENFLRLQTAAKAFMLDEAHPERRDVVGHKKSSGGADLAKLNLWNCVDEFLSVHGYGEKYFAPGAGSNIPNAPQRTLFWPRDSQFIIKLMMPLMRKMVTNERQRIYAAASRKQGSAKVTSEGQSPSVIEESITSDHHNVLETSYAEQGTEDQPLMPAQHQETETSHAVPAQPEVATAAPPVSSPPTTPFKPSVVLYVNVVSNAAGTPRRLTPRFSLTPEAAPNLAALLSEVDKRYPLPSRHGSTSGVENRPTVKVWLPDGLVTVGDDGEWMVALLSAGFVDWMDAEVRVLVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLD2</accession>
    <name>A0A1C1CLD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD-dependent protein deacetylase SIR4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_04873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLD2"/>
    <dbReference type="STRING" id="86049.A0A1C1CLD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04873"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02644"/>
    <dbReference type="eggNOG" id="KOG2683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="90"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT49297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="459" mass="49899" checksum="1316495D72C750CD" modified="2016-11-02" version="1">MPAPEDLRLRISMTSTWVKHFLKLDCARLPPSVSSSLDHPGILCLRMSHAARVSKPLMRIPFTGPLPPPLIIPPSAATKEGAVSALTHFLTAPAGSAAALPEHAQQAKTKTVLLTGAGISVASGLADYRGVNGTYTQNKSYRPIYYHEFISSHESRKRYWARSFLGWRGLHRSKPNAAHFAIRDLGTLGLVDKVVTQNVDSFHGLAHPHLKTVELHGFLRALVCLSCRTLMDRDVFQQRLAELNPAWAEFLQQLLASGALDTENPVERRRLGFRTNPDGDADVPGAPYYTFRYPACPHCLRRPPILKDGSKGHVDVDADGAWTPSPPASAPSDGVGILKPNVIMFGESIPADVKTAAEEAIDSAAKILVVGSSLATYSAWRLVKRAHERGMGIGVLNMGGVRKEEVFFGELLSDRHHGPGGGYGHNRWAALQRELVRASLPAEEILPQVVEAIRTSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLR1</accession>
    <name>A0A1C1CLR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MATE efflux family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_04783</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLR1"/>
    <dbReference type="STRING" id="86049.A0A1C1CLR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04783"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03347"/>
    <dbReference type="eggNOG" id="ENOG502RBVG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2119662at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052031">
        <property type="entry name" value="Membrane_Transporter-Flippase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43549:SF2">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN NORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43549">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN YPNP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT49434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="55425" checksum="F74A1C20B7413C5E" modified="2016-11-02" version="1">MLPSKDVVDVTDGDPPADGLSEREDATHAGNIWSRDRFCGALVYNFVGFVLPALYGTLSKLWVAKIDASMVATVDSYTYIGVVAEVINEGLPRAAWVIIGDKASRSLSSRIGLTQTLIVFQSIMGLLVSVIILGAAKQFAAGFVPEEVRTASLTYVRISSFSVFSAALETAVSNATRALDHPDVPFLIAATRFAINILLDLLIISKFHVGSFTPSVNTQAGIRLGCDFAAAFAGLTYFILIVWRLQSKHGLIEKMPRPSLRAFGVLLRPGILTFAESAVRNTFYLWLVSNIVSMGSDYATAWGVFNTIRWGLVMVPVQTLEATSNAFTGHRWGEWRKEVGVDLDKAKASWKQIRGIATPALTSAAVVLTIEVPLCIFLSLFGCKPFAHYLSGSDTVASITAHMWRTIDWCYIFYALSTELATILLSTVPRWYLYQSLVSNVFYVLPWAIVCQVANLNASDAWGYHAFVFGGSLVFSFFDVLLFVGLWTWKLSRGTLNFDKVRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLU3</accession>
    <name>A0A1C1CLU3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Deoxyribodipyrimidine photo-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_06881</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLU3"/>
    <dbReference type="STRING" id="86049.A0A1C1CLU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06881"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09753"/>
    <dbReference type="eggNOG" id="KOG0133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000003">
        <property type="entry name" value="Deoxyribodipyrimidine photo-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="9">
        <location>
            <begin position="91"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="343"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="497"/>
            <end position="499"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT49488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="599" mass="68306" checksum="D66A1D01306DBA27" modified="2016-11-02" version="1">MVPYKRKASETTIPLLPDLKRPRTSQPISDQYKDSTNEIKYGIVLRRFYPPEMVNERALAYNAGKIERPIETLEKAISETQVQRDSILPGKCVVHWFKCDTRTMDNRALHLASETAKKHNLPLLCCYLISPQDFEAHLTAPIRVDFILRNLQKLKEDLSELDIPLYVETVERRRELPSRLIELCTNWGANNVFCNAEYEVDELRREATLTRSCLEKGISFNVVHDTCVIQPGCLKSGAGGALSVYSPWHRKWCAYLNEHSGQLDAFPSPEKNPPATRQAYPELFACGIPEAPKSKQLSEEEKTRFQTMWPAGEHEARARLRKFILERILTYHENRNLPAGNATSNLSAHLAAGTLAARTVVREARDAAPSKRLTDDRKQGHSMWIGEVAWRDACALPLAIYLVSMAIAGGTRADFHSMNKPFKPEYSNIRWEYDLDQFKRWTDGKTGFPIVDAAMRQARRTGYMHNRCRMIVASFLAKDLLIDWRMGEKWFMEHLIDGDFASNNGGWGFSASAGVDPQPYFRIFNPLLQSEKFDPEGDYIRKWIPELAGIRDKGIHDPYGRGYAKVAEMNGYPRPMVDHKEARERALARYKAGIGRGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLU4</accession>
    <name>A0A1C1CLU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylserine decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_11315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLU4"/>
    <dbReference type="STRING" id="86049.A0A1C1CLU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11315"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03334"/>
    <dbReference type="eggNOG" id="KOG2419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022237">
        <property type="entry name" value="PsiD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF9">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G01730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12588">
        <property type="entry name" value="PSDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-tryptophan decarboxylase PsiD-like" evidence="3">
        <location>
            <begin position="46"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="443" mass="49998" checksum="B7AD2A3DB9713E17" modified="2016-11-02" version="1">MKHEKNIPATHHYHRLGEWLPHDQRAHREWLAGVIDLVDQKPERLHPVLAEFQDLIENNTRVYLLIASMFEQIPNKEPYTNDPQGEGHPQIRDHIHMLQVINHILTTAPSWNDKSERVGLVGLPFHALFDWPMGTSSGFAVFLDPDINKVLKKVLDAWADFLESPESAYVLKKEAKGSWFSPHGEEELTHVANVGKTSHKFEELFECDPSDPHMGFRSWDHFFTRVFKEGARPVASPDDDNVIANACESKTFKVARDVKARDHFWLKGQPYSVIDMLAHDPWAEQFVGGTVYQAFLSALSYHRWHAPVSGKLVKAYVVDGTYWSEPPFAEFKENESADPEGVVTSQGYLTATATRAIMFFEADNPAIGLMAFLGIGMCEVSTCAMTVQVGQHVNKGDQIGMFHFGGSTHCLMFRKGVELEGFPEATPEHNVPVRSALAKVRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMF6</accession>
    <name>A0A1C1CMF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMF6"/>
    <dbReference type="STRING" id="86049.A0A1C1CMF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06542"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09869"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09870"/>
    <dbReference type="eggNOG" id="KOG1041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="937"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1373" mass="151758" checksum="BB5D476AE185F82D" modified="2016-11-02" version="1">MHAHSTPPQLGTRVTFTNRMSDTAKPGTYTARITTWKPEAHEFAWKGGPLPEMMGWLLMGNHSFRLVDKPMSFLSAAVLFMEGPKVSIELRLSDCFRCSPVLVLLEINKRLQTGYMSPFPTLKQQYLAKGTKQGRLASATNAITTEKPHSLLVAPAAGEALVAAEVTTNMAVAAIMVAAGRTVHVVVAVLALGLDKVNISAERAPTTNEATATLVMAAASIIPKNQNSIDTRRGSTIDLPNGPGGLHNPANDGFGRGRGRGPSLAGGHGYTSYQPAGPVDNRRPSAHGYQQGQQQSRGFSPYNHGRGSSWSRDGTARRGSKISNHGQAPHHQAELAHGTVTHLLANYFRITVGAIKTLYQYDISIIQVDKDGKPVKEEGSGKGKQGSTQQPSTTTSQGKKKRLAIPGLKKRRLIALALQEFQQHQYFDAEVPIATDYHQKLIAGAKLSFDDEATKHRVYIDEEIGSRCTIHVDYYDEFSSRAESQERYAVTVSGPVELPLEPFLRHLQAAPPATDATAEALQEPVLDALNVIFSYRPFQQCFRAGLDELPNMATTNGKKFFGVPNHPRPGTMTSTGATLADGNSGSGGGGLDSVPGFARSVRAVRSRADNLLLNVHSMTSLFYHPTLVQDLIELWIVKHGLPWTRTDLDELADFLTNLSVRSLPHGSFHRITKLPRHEVNGRRVLPTVWNTVMRPQDRGNPGSSVADYFSLHHGASYPEDGKETYVVTVGEDAAAQTIPADRLMVMPGQRYTNPKELPFGATRRPNDNRDRVLQTGRGIFFGTHPDAKGAVQFELDLGRELLPVPFIQLDLPSVQYRNSVNPDVLVNLPRQHGPRDGSWNLLGQHFIRTSPDEQRWTYLEIQEHNGRASDPSQCTRFRAGLENALVDAGMSNFVFVPWPNYSLTLPDLNRFGKEDRFDKLCESVRQKFRELEGKVDIVLVILPNQKVDIYSAVKIVGDQVLGIPTVCSILKKGKFKPNGALNKDFPANLTMKMNLKTSTTAVNHQLAVRPPILTPKTMIIGIDVTHKPATALKGAPSIAAVVGSVDDQFAQWPVSLRLNPVQDMDESEAGPANDENPGNDKAETSDQPQPSATAKSDAPKSKPDETTKMDGPKAKSDGKQAREKVLDLEAMVFERLVDYWEHNQTMPDQIIIYRDGLSEGQFDMCRNEELPKIKRAIESLKRHRRKEHVEKNGGEDTAAELLQDDDNATIAVILICAIKRNHTRFFPADSTIKNDNVYCGVDRHGNYNFNPRPGTLIEQGVTYGDGQDFFLISQKAIIGTARPTHYVILANETHHTRREIAEMTHKLCFLFGRSTRSVGVCPPVYYADLAAGRARCYARGIYNAPDRRVQYDDNLHRPELQVHDNLKKKMFYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN65</accession>
    <name>A0A1C1CN65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative amino-acid permease P7G5.06</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_06764</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN65"/>
    <dbReference type="STRING" id="86049.A0A1C1CN65"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06764"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08876"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="60"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT49965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="579" mass="63732" checksum="B26FFC99DF23E4CD" modified="2016-11-02" version="1">MSLKNDTNALGEKHANDVPTYRAGSLSEHVRGRQFSLDPEDRAMVTADQNLLHRDLKGRHMQMIAIGGAIGAGLFIGSGGAFQTGGPASVLLGFMIIGLMVYLMMQALAEMSVMYPINGAFTMYICRFVDPSLGFACGWEYAISWLTVLPFEISAACNIIHYWPGSEGINNSAWIVPLLVALVAIQFFGVEFVLSILKIIACIGFMILGVIINCGGVPTDDRGYIGARYWHSPYEAFLNGFHGFCSVFVTAAFAYTGTELTGLAAAETVNPKKEIPRASKQVVWRIAIFYIVNLFLVGLIVPENSELYSGEGSTSRHSPFVIAIQLAGIKVLPSIFNAVILIAVMSVANSCTFGSTRTIQALAANGMGPKILAYVDRKGRPLSVVILQLLFGCLAFINLAEDGGTIFNWLLSLSGLSVLFIYGSIALAHIRFRAAWAAHGHTLDELPFRAAWGVWGSWLCFLINVISLIAQFYVALYPIGGPYLDANTFFQLYLAGPLLIFLFLCWKIYSWFARPEDRALFIRAKDIDIYTGMREEQRSRISGMGVSEDQRRASIMELQEEKKKRGPKDWLMAAVRNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNM4</accession>
    <name>A0A1C1CNM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Crh-like protein</fullName>
            <ecNumber evidence="15">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">crf1</name>
        <name evidence="20" type="ORF">CLCR_07101</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="15"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNM4"/>
    <dbReference type="STRING" id="86049.A0A1C1CNM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07101"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09025"/>
    <dbReference type="eggNOG" id="ENOG502QVQI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000159">
        <property type="entry name" value="Glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 20" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650990" description="Crh-like protein" evidence="18">
        <location>
            <begin position="22"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="19">
        <location>
            <begin position="76"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="345"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCT50116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="452" mass="46586" checksum="62E170606F046234" modified="2016-11-02" version="1">MAGPILHSLLFLAALAPSVLAQVKCGGGVKCPSDTPCCSQYGQCGVGAYCLGGCDPVNSFGLDSCVPAPVCKSKKYEFSNLDGIVPNTKYLGDPTTADWVSSGSPLEYQDSVLLTMAEGTVGTLLTSTRHVWYGKVGARFATSAGAGVVTAFILLGNSKDEIDFEFVGVELENAQTNFYSQGVPVYTNGGNTTGLSDVHANMHDYEIDWQPDSITWSIDGKVVRTLDREDTWNATANRYYYPQTPCQVQLSLWPGGLPTNGEGTIEWAGGLVEWDSPYMTNGYYFAQFDSVSVECYDPPSGANVQGSKSYIFTDPSMTNLSVEVTNDNTVLKSFLGTGTNMSANYPSNTASSSGSSKTSEVATIPGLSGGGTGSNGDRGDNSSGSNSDSDGGSGSDSGATASASGAASTGFVQGDGGDGSSNGAGSIGGNGESLLKGSLFAAIVAVVGLCIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNM6</accession>
    <name>A0A1C1CNM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histidine biosynthesis trifunctional protein</fullName>
            <ecNumber evidence="10">1.1.1.23</ecNumber>
            <ecNumber evidence="9">3.5.4.19</ecNumber>
            <ecNumber evidence="8">3.6.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CLCR_06629</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="10"/>
    <dbReference type="EC" id="3.5.4.19" evidence="9"/>
    <dbReference type="EC" id="3.6.1.31" evidence="8"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNM6"/>
    <dbReference type="STRING" id="86049.A0A1C1CNM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06629"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08997"/>
    <dbReference type="eggNOG" id="KOG2697">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11546">
        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000002">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.810:FF:000002">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000050">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016298">
        <property type="entry name" value="Histidine_synth_trifunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001257">
        <property type="entry name" value="His_trifunctional"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="19" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="24">
        <location>
            <begin position="238"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="405"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="904"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="907"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00017884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OCT50083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="937" mass="101129" checksum="0D8A234ADF7BC094" modified="2016-11-02" version="1">MGTGLLVAVDPEAILRDEVKGLTLQQVSYLGQCLVQVTPENFHSSLTFLSQNFAKLDIYLDVRKLKSWDNVVDVLNNGASKIFVTFEQLKVLAQEPTISPDRLVLTISLVSPKTDIAKLKAFLQDNPKWKTSEWAFDGDKGNELVDTVLKDLDNYPPSQDQSIYIAVASETDGRNLLHEYPGNALIVSSTNLTFDPTLPSDKDLLPAAELIVAGATPDRKTGLYATTVVDERGVALGLVWSSNESIAEALKTGTGVYQSRKRGLWHKGASSGDTQELISIGFDCDKDCLIFRVHQKGRGFCHLGTMSCWGRVSGLSRLQRTLQDRKVDAPADSYTARLFNDPKLVNAKIKEEADELCAASSKEEIASEAADLLYFALARCIAADVTLEDIERNLDLKSLKVKRRKGDAKPQYVEEKSGSEQGSAQPESNGANGHQDEDIKEAASVPKGPSDPAGQNESRRIQMTRYSTSQAFSEDVLKAALQRPSQKSNEKIMSLVQPIIADVRSKGDSAVLKYTHKFERATSLKSPVLKAPFPESLMRLPEETIKAINVSYDNILKFHSAQKPSAPLIVETMPGVTCSRFSRPIEKVGLYIPGGTAVLPSTALMLGVPAMAAGCKNIVLASPPRSDGTVTPEIVYIAHKVGAEAIVLAGGAQAVAAMAYGTESITKVDKILGPGNQFVTAAKMIVSNDTSASVSIDMPAGPSEVLVIADHTADPAFVASDLLSQAEHGTDSQVVLIAIDLDEKQLQAIEDEVHKQAYELPRVDIVRGAIEHSVTISVGSLKEALKWSNYYAPEHLILQIADPRAALPDIQNAGSVFLGGWTPESVGDYSAGVNHSLPTYGYARQYSGVNLGSFMKHITSSEVTEQGVGEVGYAVMELARCEGLDAHRRAMELRLEKLGLVPRKSVQKQAPSSPESGKHVSSTLVDGNESLTAPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNV8</accession>
    <name>A0A1C1CNV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNV8"/>
    <dbReference type="STRING" id="86049.A0A1C1CNV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07415"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05795"/>
    <dbReference type="eggNOG" id="ENOG502RZH2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="105"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="322" mass="34804" checksum="CB0B65E120388388" modified="2016-11-02" version="1">MDRLFRKFSNKSQKSSNGGSNASQRQSPIATARRNMNTNNPFTTTVPTRRPAAPEPPPPYSPPASTSASASAAHAASSVPFSPADLANTMQTGDDSPYAFLRTFDTIFLIDDSGSMAGRSWRETSSALAAIAPICTAHDPDGIDVYFLNHRNPHSTHGGYTNLTTPGAVQSLFQNVRPLGGTPTGTRLNQILKPYLAELADSLERQAHGHDATVKPLNMIVITDGVPSDDVESVIVSAARKLDSMAAEPWQVGVQFFQVGREPEARDMLQELDDALSGEYHIRDMVDTVPWSGDDGDEGLTGQGLLKVCLGSVVRRWDRRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP40</accession>
    <name>A0A1C1CP40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription-silencing protein Clr2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06654</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP40"/>
    <dbReference type="STRING" id="86049.A0A1C1CP40"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06654"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05719"/>
    <dbReference type="eggNOG" id="ENOG502SWDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038986">
        <property type="entry name" value="Clr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031915">
        <property type="entry name" value="Clr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018839">
        <property type="entry name" value="Tscrpt-silencing_Clr2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10383">
        <property type="entry name" value="Clr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="3">
        <location>
            <begin position="68"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Cryptic loci regulator 2 C-terminal" evidence="2">
        <location>
            <begin position="441"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="846" mass="95859" checksum="5C9D2E1A1DE4D032" modified="2016-11-02" version="1">MAPQPALGWEIIGRKGQWQKLHVEPYSDGEQRQWPAKPYRPSSEERYLISLAKAWAHKLGVEQPGVEYYLDNLPDGYALFELPQLKAGHIYKRLFGHPSGKYYDSTLRFQPHFLWLMSGMEGDCACIHCGNFKREGPIKHRTRHPAEKKSLGAREKRKPQLLYDSDNSSRSNSIAGPSTTGTSTRPQRQVRTAGAPYAQDEEGTEDVYKLQLKTLEAHRESKKGIEDDIREPNSIDWRAEHSWPPPNAQDWFGVDLLQQSLTAIEHQHSFVPRVGELVLFCPTFLDQHYLMLDERTQEYKFYSFEQKCFHGFPAWRAGVIAAIPSATAADGPVDFSDIQDIPKKSNSLNTGGFRVETFPDPNNEQDKTASKQYKYLPLRNIRPLSHWHLLLRGIPRTKWHPSIEHALTCMTSISLLEKFYFKGDWEKDKTGIKKPQASIRCKGVYIGSELITIGDAVRILPETKEVACTDVLVVESIRLHLRDITPDHFLPDSPLLSTQSYITLVGKAYTTNRDRYFQKNPHAHAPAPAITISPEEVKTTFRPVGSTLYGPWYALHAPQNRYEISHDQILGRLYEGAAVQLWTGLLQRKPTNGEKYIKPVLDYDLKGIQEGRVYATRADERLNESHEEPLVWFWADTRAEALDLQSINGVEVGRYDKVRDKDTLELWKTHLRILNGQQISIDNISKSFTNFDSLDSVLGLKKRGRKAGARVINNKVYYPGDAGYDDPDQEGESAVQLTPSKHKGSQLAGAALVSTEEEDSDEEAFMEAQEDWDLPVEARSESPAPVRPALLMPKQKRMKTKAEIMASAADEQSFSDDDDELYAPLPIRGGTEETEGGDYDPGVDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ72</accession>
    <name>A0A1C1CQ72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ags1</name>
        <name evidence="11" type="ORF">CLCR_06524</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ72"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ72"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06524"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05375"/>
    <dbReference type="eggNOG" id="ENOG502QSGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11323">
        <property type="entry name" value="AmyAc_AGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000058">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000073">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF2">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650962" description="alpha-1,3-glucan synthase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="2450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1080"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2030"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2064"/>
            <end position="2082"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2089"/>
            <end position="2111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2123"/>
            <end position="2143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2155"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2198"/>
            <end position="2225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2245"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2282"/>
            <end position="2302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2309"/>
            <end position="2329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2354"/>
            <end position="2375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2382"/>
            <end position="2404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2424"/>
            <end position="2444"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="65"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1707"/>
            <end position="1877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1973"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1710"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1725"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1745"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1775"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1785"/>
            <end position="1808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT50638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="2450" mass="274334" checksum="AC7CDF41CEEA7923" modified="2016-11-02" version="1">MWFYTLVSSVFLFLSSCGALRYDPAFAQYNLNQNQTATNPLDYWGEWTGHQYHPSPSNWRFPFYTLFLDRFVNGDPSNDNANGTAYEHDLNSNQMRHGGDLQGLVDTLDYLHGMGVKGIYIAGSPFINSPWGYDQYSPLDLSVLDEHFGNIDMWRSAVEEIHARGMYVILDNTFATLGDLIGFEGYLNTTTPFTLKEHRVQWKSSREYHDFHIGNNYNKTCQYPKFWLETGYPVGEDVTSQMVGCYDSDFDQYGDTEAFGVFPDWRRELSKFASVQDRLREWHEPVRRKIENFYCMMIAQLDIDGYRYDKATQSTVDAMGYMNDAMRKCARRYGKDNFFTPGEITGGNVFGSIFLGRGRQPDMMPENLTVAATMTDHSPERYFLRDQAHGALDAAAFHYTVYRTLTRFLGMDGNLEAGYDAPRNFVDMWNTFLLTNDFVNPNTGKVDPRHMYGVTNQDVFRWPAITNGVERQLLGHFITTIHMPGAPLLLWGEEQAFYILDNTASNYIFGRQAMSSATAWQTHGCYHLSSTQFFEMPLNASRRGCEDETVSYDHRDPAHPVRNIIHHMNQLREQYPVLQDGFFLQQLSNQTEEIVYPGSGNVSTETGMWSVMRSGFPGVQDLGDTGAGDLPVWLLYSNANASTTYRFDCNDNDTALNTTSLISPYDAGTVVKNLFYPYDEHTLDSSVHRLGVNGSTNPNGCLSSLDMAAYDFRAYVPKDQWVGPKPMVTKFSPGHDARLESTVSADGTESVNVEFQFSVEMDCDSVTNSITFNSTTESAATPSIDRSSIKCANLDSPQTPAYVGAISSTWSWSAKLDNVANGIHSISVRNASSEAGEVTNAIDRFLFRIGRTDNPMVFTGPANYSSSLLSKSDNGSLVISHNAAGADKWRYSTNWGSSFSDWLPYRGGKTQIERQPWSGTKLQSWKGDHVRVEYFSRLAGSSDHVQEGDIGFSTPRRFPHLFLNGPYNQYGYDAGLSNEMKLTDNNTWDHHFMTEWSLAGTLAQINVWGLNPDGKPDQTTVMGDADGDSILDRLPPSSLSSVVLNITQPPPKPYLGWRLVINDGSLRFELRPSGNMWPQLILYVLLWIVPIITASFGVWSFMQSFYQIKFNEVGISEKKSFIPAVFKRTFKKLPDEEDSPSVLTKFSRKPKFLQPTGALLDQQKRRTVLIATMEYDIEDWGIKIKIGGLGVMAQLMGKNLGHQDLIWVVPCVGGVDYPEDQKADPMTVTVLGKPYEVQVQYHVLRNITYVLLDSPVFRQQTKSEPYPPRMDDLSSAIYYSAWNQCIAQALNRFPVDLYHINDYHGSVAPLYLLPRTIPACLSLHNAEFQGLWPMRTNQERDEVCSVFNLSSEIVAKYVQFGEVFNLLHAGASYLRVHQRGFGAVGVSKKYGKRSYARYPIFWGLKKVGKLPNPDPSDTGEWDKKLPKESDIRIDPEFEAARPELKRQAQEWAGLEQNPKAELFVFVGRWSMQKGVDLIADVFPSILESNPNVQLITIGPVIDLYGKFAAMKLDRMMKLYPGRVFSKPVFTALPPFIFSGAEFALIPSRDEPFGLVAVEFGRKGALGVGARVGGLGQMPGWWYTVESMTTAHLIHQFKQAIHEALGSSTEIRALMRARSAKQRFPVAQWVEDLEILQSTAIRIHDKIEATRRHTAAGDLIGTSAWNTPIASGAATPSGFRTPTFGHSRMSSYAAVQSLTSRLRNIGHSREVSQSTPPRPNSSHSHAPSGLSRSASLGSRRGPGHVDVQDEHDGDEPRTPGFLPPIPDVGGDDTGLRTGSTQNPNEYSDDEDEDLDSDFDDDDDDDDDDVAMPKPTSPRYERIPLNDDSPQTPPSGNLRPRSRAGLELTPLQSGAHSRRNSSDQPRPESGLLVPPPVLTDNNRVSSSLSLLSMNSIVGEKTDFKLQQVDPFFTDSNGEFARAFEKKLEDLNGHNSESTACIEEFLVKSEKQWFNTFRDVKLGRYTAVSSARNSMHISRESRPTSAAPSIYGGNTDPDSHHDPNNLAEEFLLGENYKPPTGLRKWMQLRVGDWPVYAFFMGFGQIIAANSYQITLLTGEVGQSATKLYSIASIYLATSICWWVFFRRFQSRLCLSLPFFFYGLAFLLIGTAHYGSSISTRGWIQNVGTGMYAVASSSGSIFFALNFGDEGGAQVKAWVFRACMIQGTQQIYVVALWYWGAYLNKRTVTQLVSTPNPITDTWKITAITLPIALLLWAIGLLMWFGLPSYYRQAPGKMPSFYKSLTRRKIVLWFFVTVIIQNFFLSAPYGRNWSFLWSSSHAQTWQIVLLVALFFIGVWAGALWLFATLSKSHSWILPLFAIGLGAPRWAQIWWGTSNVGLYLPWAGGYTASALASRALWLWLGTLDAIQGVGLGMILLATLTRVHVAFTLITAQVLGSVATIVARACAPNKIGPGPISPDISGGVSNVWQAWFWIGLAFNLAICAGYFKVRRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQI3</accession>
    <name>A0A1C1CQI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQI3"/>
    <dbReference type="STRING" id="86049.A0A1C1CQI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07266"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05272"/>
    <dbReference type="eggNOG" id="ENOG502QW4G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="366" mass="38958" checksum="58089410A57C7EC2" modified="2016-11-02" version="1">MRNINRVMLMVHTGASSTSQREDGIAFATQFEEVDRAMDNLVKSGKFYAGGPRPMGAMRPGAEFGPRAHGGRHVVGDFDPSRPHPGANLQNFYASQRHGRQGDPDQMMQAKRRMAAQRERELRNYHQEQQYNRSVLADMSSNKSDRSMSPSTLSEEGRRDLIARQHRALYGGDPAAFVGQVPFSQEDVNRDQAGPVPSGVTVAPRGTSPRGADPFISQGEANGASGQEATLSDKVTSPSAQAPGFGTFDGAASGKASTPPTGEESAHSRQISKSTTAPMAGGMGPIGSRPNAQQPPNQSINKRTTSPLPSSLGYGFGPNEQNVDRAGSANSNVNNQKESSNNGMGTWRTGNGVWGSTKIGTTSVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQK7</accession>
    <name>A0A1C1CQK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 60S ribosomal protein L28e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl28e</name>
        <name evidence="6" type="ORF">CLCR_07647</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQK7"/>
    <dbReference type="STRING" id="86049.A0A1C1CQK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07647"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05237"/>
    <dbReference type="eggNOG" id="KOG3412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000002">
        <property type="entry name" value="60S ribosomal protein L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="152" mass="16850" checksum="16404F4463F9F106" modified="2016-11-02" version="1">MSERPNISADLIWEVVRNNNAYLVKSKQHGGFQFSRDPFNLTNKHSRKHAGFVNDKAVSIQPGENGGVALKTKKPGKTHQPASHHNTHTYSKATSNRKVYKNVADAVGKNSYRGDLNSYAVARASAIRDSQRVKKDTPEKKPRGLKGRKADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQR6</accession>
    <name>A0A1C1CQR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ALG7</name>
        <name evidence="20" type="ORF">CLCR_08472</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQR6"/>
    <dbReference type="STRING" id="86049.A0A1C1CQR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08472"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09496"/>
    <dbReference type="eggNOG" id="KOG2788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCT50850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="492" mass="54019" checksum="A942BBD148E56B80" modified="2016-11-02" version="1">MASTLNRTERWSLLLVTGGSLAVLANTFQGDGAPLVASLAFSTLAFSMTYAFVRWSGPAFVKAGLKGKDMSKIPAKEMALADLSSPESMGAVAAAVYILALIAFIPFAFYKDIVAATSGGGNRDVVVTITEVETGRFLHRFPHSKLSSYQSALNTLQATTILGICDDILDLRWRHKFFIPAVASLPLLIVYYVDFGVTSVVVPTFLVPYMPNQARLINLSFLYYLYMSALSIFAPNSINILAGINGIEVGQSLVLAGLLILNSALYLVPFPGNPVLNHAYAIRPHPATDAHLMTLYILLPFLAVSTALYIHNRYPAKVFVGDTFCYVAGMTFAVVAITAHFSKTLLLLLIPQIVNFIYSVPQLFHIIPCPRHRLPKFNARTGLLEPSVTPWSAERPPSKLLTAVFFTLEKLRLIQVTVDPKTNRISATSNLTIINLWLVWRGPMREDQLTKELLVMQSCCGLVGLFVRHTMARLIFSVDNRGSLSQAELGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQV7</accession>
    <name>A0A1C1CQV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein s17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQV7"/>
    <dbReference type="STRING" id="86049.A0A1C1CQV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08526"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09533"/>
    <dbReference type="eggNOG" id="ENOG502QU23">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2336871at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650981" description="Ribosomal protein s17" evidence="2">
        <location>
            <begin position="23"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="42311" checksum="704F552E6A1292E1" modified="2016-11-02" version="1">MKTSQLLTLAVAAFGLTTGAVAQDNARNRGGNNNQAGDAAAGNGGGNNANNGNNNAGGNGGGNGGLTLLDANVQTASDFVGNPNAEQANSETDPANFINFCTGKTLTNGTQATGGSCNGVVMGDIPSNNNMISSIILFPGPGDDLTPNQDFDIQVQLTNMVAGSFTDPLTTYYAAPQQLQGGNVVGHCHVTVQDLGIDLAPTQPPDPKTFAFFKGINDDGNGRGLLQATVTDGLPAGFYRVCTMNSASNHQPVLMPVAQRGAQDDCQKFTVGQGGGNAGGNAGGNAGGNAGGNNGGNNGGNAGGNNGGNNGGNTGGNNGGNTGGNTGGNTGGNTGGNTGGNNGGNTGGNTGGNTGGAADTSSTSTSAAAAATTTAASNAGGNGGGDSGNNGGAGASTTSAAAAAETTAADGSTSSGRFGGRGGRGRFGRGRGRFAARDYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQY3</accession>
    <name>A0A1C1CQY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carbon catabolite repressor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">creA</name>
        <name evidence="19" type="ORF">CLCR_08734</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC-rich region in their promoter. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with creB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQY3"/>
    <dbReference type="STRING" id="86049.A0A1C1CQY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08734"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09567"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043609">
        <property type="term" value="P:regulation of carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="224"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCT50924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="378" mass="40942" checksum="70338D590F008FA3" modified="2016-11-02" version="1">MAAAVSLMPTPLASQPANPEDRQDLPRPYKCPLCDRAFHRLEHQTRHIRTHTGEKPHACQFPGCSKRFSRSDELTRHSRIHNNPNSRRNQKTHQVAAAAALAGLQDGSNQNLAAQAQMMPPPNKNSMPRSAPTSAVGSPNVSPPHSFAVQASTHGPHIPTHLGPFGRSDDRNAMDINLLATAASQVERDEHVTRVPYQHQHHLFSHRSHHTTGRLPSLSAYAISHSMSRSHSQETHDEAHRVKRSRPNSPHSTAPSSPTFSHESISPTPDHTPLATPGHSPRLRPHGSDLQLPGLRHLSLGHTPLLAPMEPQADGSYSHIPPPQHTGPSIADIVTGTQRKLPVPQLPKIGVAEMLHLPGGLSSGESSSAASINGDLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR42</accession>
    <name>A0A1C1CR42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_09074</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR42"/>
    <dbReference type="STRING" id="86049.A0A1C1CR42"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09074"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09595"/>
    <dbReference type="eggNOG" id="KOG3856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT50952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="201" mass="21626" checksum="93C9ECFD84C008CA" modified="2016-11-02" version="1">MAENIPPNTASKPVTSSDRPGLPYYEKLRRDLRDTLQKKRLLDRNLPEAHQIQASIEDQIHRQESAYLEETSVAGNIVKGFDNYIKASSSTNASAGTISGSALGGGVGARRRAAINDADRVFSRSSVSYMRDSDSPSSATSTPNHAATPTGSFTAEKTGDKKKKKSTAGTGEDDTDTKTDARSTKRQKITFGGGRKSIQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRG0</accession>
    <name>A0A1C1CRG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">mcd4</name>
        <name evidence="17" type="ORF">CLCR_07962</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRG0"/>
    <dbReference type="STRING" id="86049.A0A1C1CRG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07962"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09722"/>
    <dbReference type="eggNOG" id="KOG2124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="639"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="764"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="826"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="867"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="924"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="16">
        <location>
            <begin position="449"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="788"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="982"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="990"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT51090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1008" mass="111484" checksum="FD5F8A3755DBF363" modified="2016-11-02" version="1">MARLGRGGFLALAVIFHLVYLYSIFDIYFVSPIVHGMRLYGVPQEKAPAKRLVLYVGDGLRADKAFQSFPDPSPTDPAIADLAPRPLATFLRSRVLEHGTFGVSHTRVPTESRPGHVALIAGLYEDVSAVTTGWKLNPVDFDSVFNRSRHTWSWGSPDILPMFKEGAVPGRIDADTYGAEFEDFSQDATALDVWVFDRVKELFKSASTNSTLDAILREHKVVFFLHLLGLDTTGHSYRPYSKEYLHNIKVVDQGVQEITNLIEEFYGDGETAYVFTADHGMSDWGSHGDGHPDNTRTPLIAWGAGVAQPRLFDGEKAPGHEDGFSFDWGLDHVQRHDVDQADVAALMAYLVGVEYPVNSVGKLPLSYLAATREKQANAFLVNTKQLLEMYRVKEEQKKSTSLKYQPYPPFSKANASVADRISAIESAIANNQHELAIQLCSDLFGHALQGLRYLQTYDWLFLRALITIGYLGWITFGITTVIDLHVLHGAVPDKRTTASLLAFSSILVALYSFFIIERSPVTYYGYAAFPVFFWEEVFARRNALFSGSKVLLGHIQGFSKSSSLIVQAFCFLFVIEGLVQAYFHRRILTVLYLLGAVFPASYGTDFVNKNKLILLAWAAGCLVLSTFTLLPVVKVESSTMITAGGLLMFAAGLLYLTFEHDITSQSKSAGAYGDTNILSRTLMGLQTGIILLTVIVTRSSVASLQAKKGLPVGNQVVGWLVLLASVILPFVHRIAPNKHYLHRLVIIFLTFSPSFVLLTISYEGLFYFTFCFTLLAWVRLEHAIQLHTSSQPPPSSITITSTSPTSSNIHPEQTFRTLSLPDLRRALFFLFFLQSAFFSTGNIASVSSFSLDAVYRLIPVFDPFSQGALLLFKLMVPFAIISAALGILNRRLGLQSSALFMTVMSISDIMTLNFFWMVRDEGSWLDIGTTISHFVIGSLLCVFVAGLEGVSQALISGVEVDSFEHRTKEKGGIKVVKGKGVQEHGGVNGHAKEVKKGREGLDERPVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRV4</accession>
    <name>A0A1C1CRV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRV4"/>
    <dbReference type="STRING" id="86049.A0A1C1CRV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08695"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06832"/>
    <dbReference type="eggNOG" id="ENOG502QTVK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5317787at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="394" mass="44761" checksum="18B49B0A97FAE7E6" modified="2016-11-02" version="1">MTRHTLTRAWSKGSATSESTTSDRSSTQSSRSIQSSHTQYTNLTSYSDTKAIVKHCELYEEREIVDEAEDSSSEQEDPRASTETYASTVASEPESETSKALSLRPLMRHICYEPDALATSPAEFGELFPSTKRILIQHDDTTHDGNLNLRLDTELTVSRGHKVKLTLFHLRMYDLAERQFSLRRYQRQSGREVCNSRRKYLKPVATPSPSPSTRRSLTSALTKMNLKTLKSKPRPKTPLELGEDEGSDDELNFLATQADVKATVPTDSVKIEFSNYAQVQLDRAKRGESRYDFEYWGERYSWRRNVYRDESELVFSFELVNLSSGACIAHITPDKLSLRQARREAAQGSWVPPCSMRLTEKDISNDLGDVIVATGVIALVDDCIKRHWHEPHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS01</accession>
    <name>A0A1C1CS01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aminotriazole resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_08359</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS01"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08359"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06804"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF27">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="535" mass="56498" checksum="2F0AC2EAE7F72C9A" modified="2016-11-02" version="1">MSVTATDTIELTPPAPAVSKVQKPSFPGEEAVLREDEQSTSEQSSLKKGTTAVIFASITGVTGISSLLAGLVTVVLPPMAKDLDLSDAVLLWPSSIYALTCGCSLILSGAVADVVGSRFMYLLGCLLQSVFTLACGLAKSSFQLLFFRALAGIAIAFCLPSAVSLITSYFPHGQRRNFAFAMMGAGQPIGFSIGLVVGGILADGPGWRVGFHIAAAINTVFLGLALFGLPKPADPTRLSLGRLRTDIDWPGAFILSTTLGLLSYVFASPDLTGVSVLTGSVSSIKSPTNIACLSTAIALIPAFVFWVGRQEKLGRPAIIPNSLWRNRVFTSICIDVFLAWGAFNATETLLTFFFQDIQHLSGTQTSLRFLPAPASGIATNIVMGLAVHKVRADWAVIVTMAVSCISPLLVAIMKVRAPYWEYAFPAIALNAIGPDVLFTVSNLVITAAFPEKTQALAGGVFNTVAQIGKSVGLALSAVIAGTITMQSDYPDKHGPKALMEGYRAAFWFILSVTAATLVVSLWGLRNIGKIGLKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSM6</accession>
    <name>A0A1C1CSM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein KES1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KES1</name>
        <name evidence="4" type="ORF">CLCR_08212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSM6"/>
    <dbReference type="STRING" id="86049.A0A1C1CSM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08212"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06578"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000010">
        <property type="entry name" value="Oxysterol-binding protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF92">
        <property type="entry name" value="OXYSTEROL BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="568" mass="62347" checksum="DE1407E1D7E4715E" modified="2016-11-02" version="1">MSGSTLADNRSKLKEFIASISTIRGDLSNITAPPFVLDTKSAVELPAFWAERPSVFVAPASAEDPATRALLVLKWFLSSLRNQQYAGRSEVQGIKKPINAFLGEVFLASWEDDAGLTRLVSEQVSHHPPVTACRVWNEEHGVAAEGYTRQEITFSGSINIQQIGHATLYLARHDETYLIPLPNIKLKGVLTGSPYPELQGTHYIPSTNGYTSVIDFSGKGLFSSSDKKHSFEAKVYRDGEENMPLYTVSGHWDGAFIIHDCKNDVDMETFDVMTAKTTPLQTEPLAAQDPWESRRAWQSVREALERGDMQGAAEAKAKVEDGQREMRKTDADGEQWKRLFYENESKPDEVAAMLATKVGLTFNPEDTVGAWRFRRREWDEGLFKKPYHGDLLPDNSHGDGTARNGGDRDTMVNGVTPAVSSGAAQGEEQPHPQPQPQHDLSQPYSFHRQSTIVGPEEGQQQSGPAHVTGSEQPQAQMQVDQEADSLRGKTEAASLVADRTRHESPVVLAQPERPASANMNSSDEQNGGVGQVGGGGGGGESIPQDMSPKEKAQVEDFLRDRYSSRGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSX2</accession>
    <name>A0A1C1CSX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phenylacetate 2-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">phacA</name>
        <name evidence="9" type="ORF">CLCR_08398</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSX2"/>
    <dbReference type="STRING" id="86049.A0A1C1CSX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08398"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06521"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11066">
        <property type="entry name" value="CYP_PhacA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000072">
        <property type="entry name" value="3-hydroxyphenylacetate 6 hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT51575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="524" mass="59633" checksum="C896377829BC151F" modified="2016-11-02" version="1">MLVALSPTTLSFLILTLGYFLIRYLNSTDQPKIKGLPEIPGVPLFGNLLQLGQDHARVTARWAKQYGWPVFQTRLGNRRIVFANTFDSVKHLWITNQSALISRPTLYTFHSVVSSSQGFTIGTSPWDESCKKRRKVAATALNRPAVQSYMPFIDLESCVAIKDMYKDSMEGSVDLDPRKYFHRFALNTSLTLNYGIRIDGGIDQELLREVVHVERVVSNFRSTSNNWQDYIPLLRLPFISRQNKSAAEYRARRDKYLTTFLDMLKERIANGTDRPCITGNIIKDPEETLNEAELKSICLTMVSAGIDTVPGNMIMGLGYLASPEGQHIQQRAYEEIMKVYPNDGEAWEKCLTEEKVPYITALTKEILRFWTVIPICLPRTSIKDIKYNDVTIPAGTVFYMNAWAADYDETHFKDPAKFMPERYLNDQEGSGTPHYGYGAGSRLCVGSHLANREIYTAFLRMIVAFEFVPAKDAKDWPILDAIECNSIPTALTTEPKPFKVGFRVRDKAALERWIRASDERTKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSX7</accession>
    <name>A0A1C1CSX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_08086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08086"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06526"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF41">
        <property type="entry name" value="MFS TRANSPORTER OF UNKOWN SPECIFICITY (AFU_ORTHOLOGUE AFUA_5G09940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="66"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="533"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="622"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="633"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="762" mass="82559" checksum="986FB9243B21000F" modified="2016-11-02" version="1">MSSEGLGGLTLIIPPPSNRNDMEKQPIDMEKSIQDDQKPSGPTVGPPGPPGGWLCARMTRYQEVLFNIMVAVLQLIPQSTLTTVFPVSRDIAGSFSISNPSVLPWLVAAYALSFGTFILIGGRLGDIFGHKTMVVIGFSWLSLWSVVAGLSHYVGYQLFFVARGFQGLGASLMVPNGLALLGRTYPPGSKRKIFSFTLFGLCAPVGAYLGMLFGALFTKYATWWWSFYTLAVVCSFLAIAATIILISPPPTPKQMLPVKDKLRDMDWLGAITGVGGLICVQVSLVSAPASGWSTQYIFMLLIIGLLLIAFFVITEIKIAEQPLVPFKMLKADVGFVLGAVACGWATFGIWTWFLWKFLLGIKQDTPLEAAVQVLPIVPVALIASVLTAWMMRKCRPSWTLFWALVAFAFGPLLLAVDSNVDKTVYWSWTFASLVVMPFGMDMSFPAATLIMSNYFPPQQQGIAGSLISTVVNYSISLGLGLASTVEVHVNKNGLDPMAGIRGAWFMGVGLGGLGVLICIVFIIRSIFHPTPTISNGPSGPPASGTTLQGTPLDPKISRPPTMWSLATTMTPETPGVQTPKPRDLEPFKSVNVEIASIPTAPSTPTPAPTSLATQAFHALPIASTTTQTSPKATRTEGRPQKSTETHPTRRPRKDSLECLRSQSHDRTDSQVYLQAPMSPPPPIPLPTELDAVYRSRGSFESEDGDEDRWESPREMPARGSSDLTEDQAHEHWYGYGSAPREADGCGHDSKPVTPREMVGDKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTA3</accession>
    <name>A0A1C1CTA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09370"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="76" mass="8417" checksum="E33FC8E4D39AA3BF" modified="2016-11-02" version="1">MVPKVRLGIGIRTERISSTDNELGEEEYKNTPKDLCGHSTKCRFKQWLFVLGTSGCDDLKGRKGGLLLSGKEGVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTD9</accession>
    <name>A0A1C1CTD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_08216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTD9"/>
    <dbReference type="STRING" id="86049.A0A1C1CTD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08216"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01608"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF86">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="273"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT51762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="651" mass="72844" checksum="0DBB3436694FBD54" modified="2016-11-02" version="1">MKLREMLAQLQSSAPGPAADVQYSTPSMEHTPFQSPAAPRAIQRTSTSQRAAQSVPDARQNNTRQNRPQHEQNQDQQRQQERSQDEQDTLDISPFLSVDEQGNINSFGPSSALHSSVQRPTSINALSTQHIQNGLIARAALARQNEHELYHLSEIEGVPIELAMHLFDLHWNRQHHSFLLTYRPVVMRDLRQKGPYSSRFLVNAIFAGESKFSERLEVRDNPDDPMSAGARFFRRCDQLLYEDSLLAVPRIPTVSGLLLLGSSFIARGEISKGWLYTGYALRMVYDLGLHLDRELTHENAEEVEVRRRVFWGAFICDKLQSLYVGRPIAIHLEDAHVSWKLLDTIEERDLYIPYLDPLSADLANRSKLTAPSPICSVSCFEQLCLLSKIMTRIINKFYVIGATAKEARASLDSIDESLVRWNTELPSQLRLDMMDTSTRRVGSPTPNIMNLHAVYHSLVILLHRPFISVGHLHSVATPMASWNRCTIAAKHITNVALTYRGLYSLRGAAYMLGYSLYVACTIHVRNAATLGSDQGLEHSTYLAGCLSCLREMRSPNNGISVPVKIIQKIISARNITLPSETSPPMAVSFKPSQMDYQDPIDFDMDAIFATFSSEPLAVQGSAPSAILDTTDMLGQGDLLYGFLDGQFSMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTI1</accession>
    <name>A0A1C1CTI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell differentiation protein rcd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rcd1</name>
        <name evidence="3" type="ORF">CLCR_08606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTI1"/>
    <dbReference type="STRING" id="86049.A0A1C1CTI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08606"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06302"/>
    <dbReference type="eggNOG" id="KOG3036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000014">
        <property type="entry name" value="Cell differentiation protein RCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="401" mass="44351" checksum="12788428AFBEA9EF" modified="2016-11-02" version="1">MLQTQHLYSHQQQYNQHEQSAWQHNGPQQSHAPLSHGQHQAQSQLAAAQHYSRLAVNPNHNSHAQSTNRQVVADNAQSSLGASLTAMNEQASPGMDQQLSEENRKVLQWVAELLDPNRREGALMELSKKREQVPELALVLWHSFGVMTSLLQEIISVYPLLNPSQLTAAASNRVCNALALLQCVASHNETRGLFLNAHIPLFLYPFLNTTSKSRPFEYLRLTSLGVIGALVKNEPSSNVSINPSGTPGAQANAGNSSPTITFLLTTEIIPLCLRIMETGSELSKTVAIFIVQKILLDDTGLGYICATYERFYAVGTVLSNMVIGLVETQTVRLLKHVVRCFLRLSDNNRARQALRQCLPEPLRDATFSNVLRDDAATKRCLAQLLINLSDTVADAQNDQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU58</accession>
    <name>A0A1C1CU58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial outer membrane protein porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_08710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU58"/>
    <dbReference type="STRING" id="86049.A0A1C1CU58"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08710"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06090"/>
    <dbReference type="eggNOG" id="KOG3126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000012">
        <property type="entry name" value="Voltage-dependent anion-selective channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00558">
        <property type="entry name" value="EUKARYOTIC_PORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT52041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="305" mass="32249" checksum="CEBB4AC660150FFE" modified="2016-11-02" version="1">MPGIPVPFSDIAKPANDLLNKDFYHTTAANLEVKSKAPNGVVFNVKGKSAHDGPISGSVSTTITRDQLRISHVNGQGKIEGKYTDKATGLALTQTWTTSNSLDTKLELEDNITKGLKAEVLTNYLPAKSTYGGKLNLFYKQPNIHTRLFTDLFKGPTATFDVTLGHEGFLIGAEGGYDVGKAAITKYALAAGYSQGSYAAAITATNNLTVFSASYYHKVNTLVEAGAKATWDSTAGSNVGLEVATKYKLDPSSFAKAKINDRGIAALAYNVRLGTGVTLGLGASLDTQNLNQAAHKVGASFTFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUA3</accession>
    <name>A0A1C1CUA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUA3"/>
    <dbReference type="STRING" id="86049.A0A1C1CUA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09272"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06065"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="100" mass="11121" checksum="1EC03913562A08DC" modified="2016-11-02" version="1">MLPAYSASKAALNVFVLCLREQLRNSSVKVIELSPPPVQNQGRQLGMPVDKFCDAAFDGLLSGSDQIVIGSVGPAHHFHDIVDKRREAFENLAKMMRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUC1</accession>
    <name>A0A1C1CUC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08518"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06031"/>
    <dbReference type="eggNOG" id="ENOG502RZ72">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5360701at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="479" mass="52643" checksum="D523A1180736D931" modified="2016-11-02" version="1">MATVLPRRGSYVCRSCQKLSTAQPSRRQFVSQVAHPPKQETSSNSRRTIAVPLRKRPAQSRDFQPAQNRLTPAQASKPVNTRFPPAKAVASTVDDPAQKLKDFEKFVAHVQSTDAAADHDDVLETLMDMYELSNVLVHGTRTISDENGLGSSSTPSSSSSSSSSSSSTSSSQGRDIEDALLDDLVEDKSTAAAVSRPDDSVPVSSHSQSQTQSQTHTQMTASFRTNAAATLCHLSYTLLRDAKVYITEDMLQMYVRLLCQLGKPEYLPEIFHLYATKPIPRAGSAGPVKFSSPWPKLPKYAIPIDLAEAALESAILQKNLPLAVAIIDTTVAAAAFRTNRMLRKAGVPGAIVAATPLVAYAGADWVAQWQNTMDVEMAKWTAVAGAAAYIGTLSTIGFVAVTTYNDQMVRVVWRPGTHLSSRWLREDERRFFDRLALAWGFQDKARWGEEHGVEWKRLRDEVGLRDMILDKTDLMEGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV70</accession>
    <name>A0A1C1CV70_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_09910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV70"/>
    <dbReference type="STRING" id="86049.A0A1C1CV70"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09910"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03786"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306:SF7">
        <property type="entry name" value="AHBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT52383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="600" mass="67085" checksum="40B2EEF245860297" modified="2016-11-02" version="1">MDVSQQERSSSFLHHTVTGALHHPVQALIVLVFVVAVATRVVTGLQYRAAVSNQPQANSPRTVPILPYWIPWIGHGISFAAGGTTFLSAAARSLGGNGSVYALWMANSKHNVVTVPSLAKQILMDRSSPITMEDLIYHVMKTFWGDGGAIRAIDPAHLWGNIHGVLSGMLRESFVTTAIKVTVDMVQERTWNMISGAVSPVDQSIWERQGNVEIVSKGKSDGDFVAEASLMPLIRYFVGDIATTVLFGKDFMENNPNIMPDLWQMDTRFNLFLTGAPSWFPGMAGPAKARERIVRAIDEHHQALFKYLDGQDPGPRWSDMSDVSSVMVDRARAFRAAGSSPRGWATGNGALLWTMNINSNAVIFWMVWYVFSTPSLLQEIRREIAPYVRLRQPAATGLPIEEQPKLEIDVAALWAKCPLLKGAFFEAMRLEAPSMSYKMVEDDFVVYEDEKDARNLGKKEPQSWLLKKGELICIPHGVHQSDEKYFRDPDRFDPRRFWAKESQATEKGENGHVNGAAEEEAEVRVEYKTMKVWGGGKQMCKGKTFAEREVVLFGAAIIMQWDIEPVDNGGKWVHPGRIVGAGAMNPKRDVRVRMRRREGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV96</accession>
    <name>A0A1C1CV96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SOP1</name>
        <name evidence="3" type="ORF">CLCR_10647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the caleosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV96"/>
    <dbReference type="STRING" id="86049.A0A1C1CV96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10647"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03826"/>
    <dbReference type="eggNOG" id="ENOG502QQD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="640742at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007736">
        <property type="entry name" value="Caleosin-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495:SF0">
        <property type="entry name" value="BINDING PROTEIN CALEOSIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495">
        <property type="entry name" value="PEROXYGENASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05042">
        <property type="entry name" value="Caleosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="265" mass="30481" checksum="F1164ED1B43860AA" modified="2016-11-02" version="1">MSPYIEHPACPAHRVSIPQAPVTERYKAHVPPNNSQLKNSGLVYTTYAPTSESPDGTVKDDWAEKHQHQTVLEQHCSFFDPDGDGVIWPIDTYRTCRSFDWKIPTSLFFTAFLHAVQSYNTNPGWVPDPFFRLWVKNAYMNKHGSGTGTFDSEGRFRPQPFEDFFTKFDQDGKGGLTKWELWHGLRRSRLAFDFFGQVSAMFEWGFAWVLIWPEDGILRKEDVRRLCDGSLYREKQVAPERQKGRPAAASRLTNGTSHETKSKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVW1</accession>
    <name>A0A1C1CVW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_09864</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVW1"/>
    <dbReference type="STRING" id="86049.A0A1C1CVW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09864"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04056"/>
    <dbReference type="eggNOG" id="ENOG502RFF7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G12570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="285"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT52672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="609" mass="68079" checksum="DC181E508AFC474E" modified="2016-11-02" version="1">MPACRLCQRANVDCTIFDHALQQTLSRKYIQCLTSRLGHLKAKYAAVTLEAVAGRQALLEDIPDRLRTHRAERDSSSVQDSAPDIDHGGDFNNHFPVPSVTGSTSRFYGSSSVFALAVETLALASDKNLFSPSSPREPLLSAKDGHDRDLDSVAPTAVFDTGRDFVQSLIADYMASINVIHPCVDETHLERDLDRFLATSGALELDADKLQRIEKYQCFRIAMMCSISCAAKARHSPSLMAYGNQFYAQAVRYVEEVTAEVSPQSLEALLLLVIYCLFNPRKGNIWKILDFACRLSVQLGYHTEQGHSTSESEADKAWRRTAFWNLYSIERLVGQCFGRPSDLPSSIVTTEYPTVLADPALLDNDSRQKVAAAQGFHLMFLRSEIYTDIYLSAANPHPRLEWFLEQHAALRQWYQNPSQSYLINDSKNLAGVGEITRDIMYHSSVLFLFQRHLLESLATIRHNRLPQRDSLTIASEPYHSSKILLKLYTLIIRPTTSNSPLSIFPVTFLAAYSIFQAGMTLISFALLSLESDGVEIQSPSAPTAGGHRDSERGRYGEQKLDFSDLLTLSNDCLVLLAWCKEQWPGMEGMVDAFARCSAETIPKVLRVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVW2</accession>
    <name>A0A1C1CVW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="3">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_10374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVW2"/>
    <dbReference type="STRING" id="86049.A0A1C1CVW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10374"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04017"/>
    <dbReference type="eggNOG" id="ENOG502QUM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651104" description="endo-1,3(4)-beta-glucanase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="7">
        <location>
            <begin position="37"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="363" mass="38734" checksum="DD18475D6ABFF0BE" modified="2016-11-02" version="1">MVATALLLLLVSVFFQAAFAAYQIVQDYSGDAFWQGFDFFTDPDPTDGLVQFQSLEAANSSGIAGFIDGGNASFAIYMGVDTEKVAPEGRAAVRVTSSQSFQHGLVIADIVHMPGGVCGTWPAFWMVGSDWPNNGEIDIVEGVNDQPTNSMTLHTSEGPVISDRTDFSGQVITSNCDINAPDQPMNAGCSIGDISNLTFGPEFNEAGGGVFATEWSSDFIKIWFFPRGSFPSDIVSSSPNPSANWGTPNSLFQGQFNIDDHFRNLQIVFDTTFCGQWAGAAWDTSTCASLAPTCEEYVANNPADFADAYWAINTLQVFQDDGAGSGNVNANPGKAKRGAAGTHILAGEVFQSRSAKAILPIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW50</accession>
    <name>A0A1C1CW50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW50"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11000"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04099"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="113" mass="12251" checksum="E0EF65A1980A5874" modified="2016-11-02" version="1">MSSQDASECEKDVIEDQSVADRRLGNHALTKEITHPELRRATSTLSRIASRLSTREDIDPGPPPDGGLKAWSQVAIGFTACFCTWGFINASLPYPSDKCPCYPPVDIGGANKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWF7</accession>
    <name>A0A1C1CWF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-repair protein XRCC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWF7"/>
    <dbReference type="STRING" id="86049.A0A1C1CWF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10136"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04221"/>
    <dbReference type="OrthoDB" id="420422at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19490">
        <property type="entry name" value="XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030547">
        <property type="entry name" value="XRCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="438" mass="47873" checksum="E032E6D1A41D024B" modified="2016-11-02" version="1">MAAEHYGARLLEDVQEESLEKFLADLRHITCPRPRAVFGVPQLDKLLEAVRYPAEKTTTPQRPAWQSPEHHDSEGEGQQDTDISLHGRYVEAAAVPSKAQARVKPKPATIELTSQTSASGKTALLSYLAAVSVLPRHAGGKESVVVYIDADGRLSARRLKQIMYHYICEQRQQQQQKSNQQFNNPGNNTSLSPSIPAEAKVSLDLDVNTTIQEALHHVHVFRPQSSSQVLSILSNLEAYLLDTSGRQSMCTHRPLGLVIIDPATAFYWQDRFDRAMARLETVPGQGTQGQRPSSMTFRIIERLKTLQTRFECAVLFSTTVVSLAHPSGSDAPASVTPAGAGVGAGAGPADDGRSMSPWTGYATLTLALARMPVARFTPKMGMDECVSVRERRFEAVRQGRFTAVVQHMKAVEGGRTAGVAGFRFSITEQGVEVGWIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX30</accession>
    <name>A0A1C1CX30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX30"/>
    <dbReference type="STRING" id="86049.A0A1C1CX30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10756"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04347"/>
    <dbReference type="eggNOG" id="ENOG502S71G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3930290at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20292" checksum="1BE1F72FFE46F53E" modified="2016-11-02" version="1">MATEVIVRESRRRYIWPEVQLNLWIFIVLAGSSTVLGINAWFIAVQEQMRLGVPWIFTFAVITGGLTILFLIIILILAARRMLIPGIILLGSFVLFVLWVTTLIETAVQLYGDGNVNGNCNNYVNNQEFRGVSIETLAWLTQSNICSCWKASFAWSIILAVLFLWMMILSWQVQNFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX45</accession>
    <name>A0A1C1CX45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C-signal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX45"/>
    <dbReference type="STRING" id="86049.A0A1C1CX45"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10947"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04367"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="154" mass="16174" checksum="6A5C04CC5425BEA7" modified="2016-11-02" version="1">MPVYVVTGANRGLGLEFVRQISQDSSNTVIAAVRSLQGELDDLKHLAARAAGKKVHILECDTGDMDSIHAFGDAIKGPLSAGQQIDYLLNNAGINATAQQTSLDMTPESLRQHIDVNVMGPAETVKVLLPSLGKGSVVLNMTSGLGSCGKKLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXR3</accession>
    <name>A0A1C1CXR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11039"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="111" mass="11988" checksum="2AF9CA7080C0219F" modified="2016-11-02" version="1">MQDLTIPRCDRKRCKAPLDLKTLPLLWLSLTPTKPQPPAVGDMNPRRKSLPGGATKCSGYIAVGILAAQTAAIIMIIHHFVPQQQLCKQANEAGVVLAEGAVWAFGMIVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXT1</accession>
    <name>A0A1C1CXT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXT1"/>
    <dbReference type="STRING" id="86049.A0A1C1CXT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09917"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00272"/>
    <dbReference type="eggNOG" id="ENOG502QTDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1751210at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="282"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="599" mass="66070" checksum="EF8E7B606BE8201F" modified="2016-11-02" version="1">MSGYDGAGQPGFMSTLTQFRTSRHVANQRPEFQAPVMDNAMFYGSYPPTPYDHHPLLQPGNVQDADFPYLTGSDYSSEKSFVQGSAPSVESHNGKEAELKAFRAHHHPVASTQSIPTLSRKRKASVEEEYDLPAQKKAVLAQVHVQDPNGDYYDLSGQTSPYSPFVPTPTGSTGLPAYASHGASPRSSSHHYSTSTASQCSLAAPSPHTPAFSPSFTTVKSEQSPRAPMTPIPRPTTGSPLKSSIPRLVRTSTMQQSPPGVFSSMAVGQTQTFNPYAMQALKANLKLKGDLDSMKDDWTAEEKEARRRLVVFEREQTGSTICGSFKAVSPDQRQASSICISCIWWKEKNEFYVTSVDTIYLLESLVGVRFTVEEKNRIRRNLEGFRPMTVSKARADSEEFFKVIMGFPHPKPRNIEKDVKVFPWKILGTALKKIISKYSASYSSTAASLLTPASSIYQSEPMSEYPYPSSPQPEYLAASGYHVNPDMGYLPQHPMHMRGPGPVATAPPELQLQMPQPQYAAAYEVNNAYMYQNGVPVTQASMSMQSHPMTAPVTRMPSWEYANFVSDSPVTMAPQSAPPTGYPRGPVGRVEFMPTMHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY55</accession>
    <name>A0A1C1CY55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GPH1</name>
        <name evidence="12" type="ORF">CLCR_09513</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY55"/>
    <dbReference type="STRING" id="86049.A0A1C1CY55"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09513"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00369"/>
    <dbReference type="eggNOG" id="KOG2099">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT53401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="896" mass="101897" checksum="9945BE4C53873E08" modified="2016-11-02" version="1">MAAAAAAQTPRERKPSTSAPISTLTGPVGPGFTRPKHKRTATGFGAGDIKAVESSIPEHMREAWRKFSPRGFTTKEEFEAEAVKHIETTLARSLFNCDELAAYSGTALAFRDRLIIDWNKTQQRQTFADQKRIYYLSLEFLMGRALDNAMLNVGLKNVAKEGLADLGFRIEDIIEQEHDAALGNGGLGRLAACFLDSLATLNYAAWGYGLRYRYGIFKQEIQDGYQVEIPDYWLDFNPWEFPRHDVSVDVQFYGWVNKYTDDEGKQIVSWQDGEIVTATAYDVPVPGYGTPTVNNLRLWSSKASSGEFDFAKFNSGEYESAVADEQRAETISAVLYPNDNLERGKELRLKQQYFWCAASLHDIVRRFKKSKRKWSEFPDQVAIQLNDTHPTLAIVELQRILIDMEGLEWDAAWDIVTRTFGYTNHTVLPEALEKWSVPLVQNLLPRHIQIIYEINLYFLQSVERRFPKDRDLLGRVSIIEESQPKMVRMAFLAIIGSHKVNGVAELHSDLIKTTIFKDFVKVYGPDKFTNVTNGITPRRWLHQANPRLSELIASKLGNYEFLKDLTLLNKLEPYVDDKDFKKEWAEIKYANKVRLAQHIQKTKGYSVNPKALFDIQVKRIHEYKRQQLNIFGVIHRYMAIKAMSPEERKKLVPRVSVFGGKAAPGYWMAKTIIHLINKVGDVVNKDPDVGDLLKVVFLEDYNVSKAEIIIPASDISEHISTAGTEASGTSNMKFVLNGGLIIGTLDGANIEITREIGEQNIFLFGNLSEDVEDLRHHHFYGDYQINSELLKVFDFIKKGTFGDESAFGALISGIVEHGDYYLVSDDFNSYCQTQDLIDEAYKDQDSWVSKSIISVARMGFFTSDRCINEYADSIWNIEPLQVKEENEVRSRTGLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYK9</accession>
    <name>A0A1C1CYK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetylornithine deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_10219</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYK9"/>
    <dbReference type="STRING" id="86049.A0A1C1CYK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10219"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00484"/>
    <dbReference type="eggNOG" id="KOG2275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03895">
        <property type="entry name" value="M20_ArgE_DapE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010182">
        <property type="entry name" value="ArgE/DapE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033687">
        <property type="entry name" value="YodQ-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01910">
        <property type="entry name" value="DapE-ArgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005306">
        <property type="entry name" value="PRK06837.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF25">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="8">
        <location>
            <begin position="208"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT53518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="430" mass="47363" checksum="75ED5CC0AB59555C" modified="2016-11-02" version="1">MPDLTEDLVAAIAKSVSDGFDDQIAYTQKLIRYGGQRGEETEVQNFVFQQFADRGYDPVKFDMDEEAIGNHVGGGKFSATHSRAPCVVGRHKPKAQHAAGKSLILNGHIDVVPLGPVDMWDGDPYSAKIVGDKLYGRGAGDMRGGHAAYLWALDALRRIGLQPASEVILQSVPEEESTGNGTLMTHLKGYKADAVLIPEPVQEKLVRANVGVLWFQVEVRGRPVHVRVMSTGTNAIDACWKLVEPLRELEAEWNERHVNAKFFEKEKHPLNLNVAMVNGGDWQSSVPAWCRIDCRMAIVPGVSAQAAAQEIEKKIADFARADPYLSEHPPKVTWNGFYAEGYVLEPGSDAESVLRTAHKQATGEDLDYQTSTAYLDARVHSIYDKIPALVYGPISGDIHGFDEWVSVESIKRVTIAIALFIAQWCGTEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYM7</accession>
    <name>A0A1C1CYM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYM7"/>
    <dbReference type="STRING" id="86049.A0A1C1CYM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10411"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00596"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF80">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="65"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="231"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="331" mass="35524" checksum="1320B38F9557A9AD" modified="2016-11-02" version="1">MSSPEPATKAPESDAMATDTQTSLISTQDSKAQDGPSMGEHCVTDRPAPSNRQPSGEMSKMGDIDVYISKPADYPNTPAKLLLLLTPGTGVHSTNNQVQADMFAQEGFVVIMPDQFKGDPAPNSNTATLSSPVESQSPGLLERIKLGAVETAKSFMVDMWLARQTAEKVLPVLLKVIETCKDEYVDAVAHGEGIYGVGYCFGAKYVVMLAGEHQEIAPPGQGAKDVEAGSATNGPLIKAGAVAHATLVTREDMKAVKAPLMLICVENDPLFPEEVLEIGRKYFAASNVEHEISTYPEVPHGFAVYGDYDSPAIKQAQETAFQQMLNWLKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYQ4</accession>
    <name>A0A1C1CYQ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N,N-dimethylformamidase beta subunit-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYQ4"/>
    <dbReference type="STRING" id="86049.A0A1C1CYQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09633"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00585"/>
    <dbReference type="eggNOG" id="ENOG502R8XS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5287072at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046540">
        <property type="entry name" value="DMFA2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20254">
        <property type="entry name" value="DMFA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N,N-dimethylformamidase beta subunit-like C-terminal" evidence="1">
        <location>
            <begin position="332"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="812" mass="87945" checksum="EABE547E59CB1C25" modified="2016-11-02" version="1">MSTIDTIDTIDTIDTIDTIDTIDTIDTIDTIDTIDIPPQGYPPEITGYADPWIANPGEEVAIKVSCTEPEYSHRTVRVVQGVEVEHSPLKRLEAITQIPAGTAKGRFQCARPGSYAVVEQGLGGLLHGSPASESARLQVSLFFQAHLPIAAGQGHAQAIVSTLNRGANRGFAVVINEAGVVEAWIGTGDAVQVVHTGFSPARQRWVDMTLTLDGMDCSLVLRPVAYILEKAAPVSVSRVRLAGPAVWASSTDPLLFAATYDQVPGPGVTSAGQRAAHFFNGRIDSPTISRVEGPTKSVTVLAKYDFSRNMAEDTILDVSGNNLHGVLVNAPTRAVTGHDWDGSEVDWTKATYGYGAIHFHEDDLDDARWDTDFTIKIPETARSGIYAVEVTSTNGKTSDMITFVVRPTPATTAAVGAKVAFVLSTFTYLAYANEKLSDTDRSSAIEVAPGFDVSSIRRDEDYDRLMRRKDLGLSNYDVHNDNSGVVFSSAKRPILNFRPGYIMWAFERPRELSADSMMIGLLERQGIPYDVVTDHDLHFHGAATLAPYNTILTGCHPEYPTLQSYNAYEDFARQGGSILYLGGNGFYWVSSVDPARPWRLEVRRGDQGVRSYALPGGERVMSLTGQQGGLWRSRGRSSHGLFGVAFCGEGTGPGVPFKRNDESYDSKFDWMFKDIPSDQLIGENGLGGGASGDEIDSFDLLCGSPATATVIATSTGHSDEFGIAPECTAFPITGTLGTQTKEIRSDLVYYETDAGGAVFSVGSINWYCSLGWDDYANNVAKLTENVIREFMRRGRGGLNQDNISTTVSLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYW8</accession>
    <name>A0A1C1CYW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYW8"/>
    <dbReference type="STRING" id="86049.A0A1C1CYW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10268"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00674"/>
    <dbReference type="eggNOG" id="KOG4562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="90"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="431" mass="48141" checksum="73AE20E5CAEB07CC" modified="2016-11-02" version="1">MPRQLKRRSDAISRNQHDSADPEDEPPQRAQRRQRQRSSSSEQPQRPQQQTHRREQSSSPEDSDGPSSPGRGGEGGGRGHSAENVLIKKLVRLALATEYSRTPLRRSDISAKILKDANTNTGGSRASFQKVFEGAQKVLQDTFGMQMIELPGREKTSLKERRTQATQTKVSSSASSKSWVLVSTLPPELKTNPLLMQPSLAPNVETEANYTALYTFILSLIFLNASSITDQKLERYLKRVNAETYTPMGSKEKLLQRMMKEGYIDKRRDTSSGEEVIEWVPGPRGKVEVGVQGVMGLVRTVYGHGAVELSRDTTVTRRDGTREDEEGEDEEEPGRLVKIEEEELNAKLSRSLGIKINAHGRDETGKDQHDDGDDDNEEEEQQEEEQDDNQPGPSRRAAHRTRPPNNVGRNQGPGRGGGRRNARHDDEDDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ26</accession>
    <name>A0A1C1CZ26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ADIPOR-like receptor IZH2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">IZH2</name>
        <name evidence="9" type="ORF">CLCR_10427</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ26"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10427"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06324"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT53765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="330" mass="37008" checksum="A977BD50D9ED3B72" modified="2016-11-02" version="1">MVSAPRLRGSPPQPPEAHKGGDMGSISDTAPEPGKAGRPVLLSFDEMPEWYRRESNQWILHGYRPISGSARASFYSWSYIHNESVNIYSHLIPAVFFLLGEWYIQQYLASRYSGVTGADFVAFSIFMLAAVTCLSLSATYHTLMNHSQHMEHFCLRLDMLGVVIFILGDLVLGIYVVFWCEPLPRNIFWAMIGVFGTLTIFMTMHPKFQGSKYRLFRALMFVATGLCGVAPLIYGLSVFGMSQMMRKAFPYTLAKAGCLLSGTWFYARAIDPNTCGSKTRFPESRYPGKFDLWGSHSIFHILVVCAAVVQLMGYLDAFDYAHANLTCSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ86</accession>
    <name>A0A1C1CZ86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ86"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11035"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="77" mass="8744" checksum="FAC4BBDD44CB3385" modified="2016-11-02" version="1">MTSDWISSTWDPSATEKVRLFSLLSDKQDNTPDNESAVGMAALDPDSIHYMHYQGQKSKINNNSAFNDYDGPYKRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZQ1</accession>
    <name>A0A1C1CZQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA polymerase-associated protein LEO1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZQ1"/>
    <dbReference type="STRING" id="86049.A0A1C1CZQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10137"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00907"/>
    <dbReference type="eggNOG" id="KOG2428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="468" mass="52803" checksum="6A8FBB921942EDFD" modified="2016-11-02" version="1">MSAEVESAVNPSLEEDDLPDINGEAASDDDGDLFGDDEDEAQDKRLDDTELDSGDDEGRNDRVAATVEDEEAIYEEQKQLKLLDVDVARIKPPEGDELFLVNIPEFLGIKHRNFDYATYEPPTKPHDGSDAKFSAFSTANTSLFWRRDPQNPDNIQSNGRIIRWSDGSFTLQIASKPTEHYRISTTAMRPGWPRKTTHQEHYDPARESNNYLGAPHQTIGMDLQIVAPFDASMKIQPTGDVADAAELKLRQSIAAKAELNDVPSSFKSVKVDPELARKKAEQAEKDVARSARKREAAAERQFTRRDKVLGRSGLGRSAGLTIGGLEDDMPTARGVKAKHPRRKSNRRGDILSDEDEDDEAYRRRGREDEYDREDDFVADSDEEPEVYEDDGAEEPEAEEEDDPDNDDLEIEGRQTVVENRTRGGARDRERTPKRSRNDEDDDAEAEDDTEVRRPAPRKQRRIVDDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0R1</accession>
    <name>A0A1C1D0R1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS8m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MRPS8</name>
        <name evidence="9" type="ORF">CLCR_00973</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0R1"/>
    <dbReference type="STRING" id="86049.A0A1C1D0R1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00973"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01696"/>
    <dbReference type="eggNOG" id="ENOG502S6CR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000006">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000005">
        <property type="entry name" value="Mitochondrial 40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="170" mass="18895" checksum="606E6B8602F60DD2" modified="2016-11-02" version="1">MSLVHLANTCSHLQNASRARLGLTSIPDTKFHLKLMLALQNSGFLSTVVRGGPLPPPSHNLLSHPSSSNPEAPIEPVTRHNVASRRLWLGLKYWNSAPVIEKMELVSKPTRRIWMDVEGLRRLVLGKKSGYVQGLTRPGECLYVSTDVGILEARECVERKIGGQLICRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0S5</accession>
    <name>A0A1C1D0S5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar membrane amino acid uptake transporter fnx2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fnx2</name>
        <name evidence="8" type="ORF">CLCR_00236</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0S5"/>
    <dbReference type="STRING" id="86049.A0A1C1D0S5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00236"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10187"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="66"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="561" mass="60588" checksum="CB823AD9707235FA" modified="2016-11-02" version="1">MANVAVDERSALLPGDHTGASSDDLERRQSYTSSLRRISSANLPPYHEDRTPTTDEPSSALTIWTVVPVSLLGVFVANLDGSLIIASSQQIASEFNALSNASWLVTSFVLALCASQPLYGKLSDIFGRRSNLTVSYVFFAAGCFLCGVGQQYWQVIAGRAISGVGGAGMTALVSIIIADVVPVRQVASWRSYVNIAATTGRALGGPLGGVLCDTIGWRWCFYGQVPPTIIGLLLILWKLPTRTVKTSKPADDEDDEENEVSVRQKLARVDVPGALVLMVSIVSFLLALEFVTEDLPLASCVIPGVVSLLSLALFYRIEKRWAKEPILPIELFTNADTLTAYVLVGVQMAGQFGLFYSVPIYFQIISGTNVGQAGLRLVPSVVGNATAGLIAGYMISRTGRYKVLTVLGNCAGWVGYFLVLLRWGRSRAAIHPAETLYIFLGGFATGTDQSTTFIHLAANLDASKMAVAGTTLYLIQNLFLLIGIQLATAILQARLRIRLDEGLDGVKHKEKIIDSVISSVRSIRTLPPRIRDVVIGAYLDGLVWFATLGVIAALFLRERKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0T0</accession>
    <name>A0A1C1D0T0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LYR motif-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lyrm2</name>
        <name evidence="9" type="ORF">CLCR_00998</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0T0"/>
    <dbReference type="STRING" id="86049.A0A1C1D0T0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00998"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01642"/>
    <dbReference type="OrthoDB" id="74240at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20262">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045293">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF0">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="8">
        <location>
            <begin position="39"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="112" mass="12860" checksum="A963B98A2B4A667D" modified="2016-11-02" version="1">MRSSLLRFASVAKASPAPSPKSRLRKPAPLSLDHFIQRQRVIHLYRDILRSIYRHMLSPQRDESVAYAKGEFARNKDVKEIERIRYLISTGKAEWDGLRRSVEGMGPVKGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0W2</accession>
    <name>A0A1C1D0W2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pre-mRNA-splicing ATP-dependent RNA helicase PRP28</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pre-mRNA-splicing ATP-dependent RNA helicase prp28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">prp28</name>
        <name evidence="21" type="ORF">CLCR_00782</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the U5 snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0W2"/>
    <dbReference type="STRING" id="86049.A0A1C1D0W2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00782"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01664"/>
    <dbReference type="eggNOG" id="KOG0333">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000322">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="350"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="381"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="597"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="755"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="350"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="794"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OCT54397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="805" mass="88138" checksum="F15B04861519DC24" modified="2016-11-02" version="1">MADTKVNGHHDIGLPAPPIDPIARPETPPPPPVFESEAPPPPVDDAVPPPPPAAGKRAPASKPKATPLSVEELLKKKREADAAASKPKFLSKAERERLALEKRQREVEAAAAVKSQNGAAVTRFGVPAHPGSNGKSSSTAPTGPRAMRNGEVPTSPAAMRSREPNKSHDFTPPTAPKAIAFGDSKKRPPEEDRTEKAETELIRQRYMGADMNVSTFSAVKKRKRTTEKKFNFEWNAEEDTTPDYNPIYNNRAAPSFFGRGRLGGFDDQAADEAARKYAEALASRDTVAGAERAQALLEMERKRKEASDRMAIDKHWSEKRLDQMRERDWRIFKEDFNIATKGGGIPNPMRNWKESNLPRRLLDIIEQVGYVEPSPIQRAAIPIALQNRDLIGVAVTGSGKTAAFLLPLLVYIAELPRLDEDDMRRNNGPYAIILAPTRELAQQIEIEAKKFATPLGFTVVSIVGGHSIEEQAYNLRNGAEIIIATPGRLVDCIERRIIVLEQCCYVIMDEADRMIDLGFEEPVNKILSALPVTNEKPDTEDAEDMRAMSRHLGGKDRYRQTMMYTATMPAAVERIARKYLRRPAIVTIGNVGEAVDTVEQRVEFVAGEDKRKKRLAEILNSGQFRPPIIVFVNIKRNCDAVARDIKSMGFSSVTLHGSKTQDQREAALQSVRDGKTDVLVATDLAGRGIDVPDVSLVVNFNMATNIESYTHRIGRTGRAGKSGVAITFLGNEDNDVLYDLKQMLMKSSISRVPEELRKHEAAQQKRGAQFAGGGGGGGGDKGGPRGKTASDESGGFGGGKGGGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0Y1</accession>
    <name>A0A1C1D0Y1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retinol dehydrogenase 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RDH8</name>
        <name evidence="2" type="ORF">CLCR_00917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0Y1"/>
    <dbReference type="STRING" id="86049.A0A1C1D0Y1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00917"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01766"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF6">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="293" mass="31169" checksum="4DA404A1E51F358F" modified="2016-11-02" version="1">MPVTSKAPVWFITGSSAGLGLALTRHAMAQGHTVIATSRNPSKTPELVAEVEKSGGKWVALDTTQSEEELNKTVQLAESFFGRIDILVNNAGMCVLGALEDIPFADTVYQMQVNFLGPLRIMQAVLPGMRKRRSGVIMNVSSAQGVAAGLACGVYAASKAALEAASESCNLEVAQFGIRVLIIVPGAYRTNFGKSDVGKQITPSEEYTGSHPVSARLDHITKLPSTAMGSPDKAAKVMFEAATGEGEVGELIKKEKLLRVIIGPDCWNVVDGKIRELRRTTDLLVDVAASTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1A2</accession>
    <name>A0A1C1D1A2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiaminase-2/PQQC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1A2"/>
    <dbReference type="STRING" id="86049.A0A1C1D1A2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00852"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01745"/>
    <dbReference type="OrthoDB" id="37730at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19357">
        <property type="entry name" value="TenA_E_At3g16990-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053261">
        <property type="entry name" value="Polyketide-peptide_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813:SF2">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="54899" checksum="8EBEB5B3AB4F56A6" modified="2016-11-02" version="1">MWHNAQDVHHVHRQQSPPGAYHHHHHHHHQQNTMSDQMSVSSATTGVASNQPGHAQYQNYNHHLNPGVGLSASANDSAYAVQQQPQRMEPLQNHHHPPTYFYPSRHLHNQAIPLHAHPLSQHPPTPYISSPAPPPFQTQSPPSLTSTLLASSPHQLSLATQHPFLRVAGQGQLPKLTLSRWLSQDRLYAQSYIGFIGSLIARVDLPYTHVPDKSTSLRWRLVQCLTAALQNIHTELAFFATTAHAYGLDLEAPSLSSSSSSSSSGRVFGPEPATKQYMDLFRAFWTDPSMTLLEGMVVLWATETVYLRAWTYAASFLKNGTSSSLLPLSKQLQRIELDERDTDNDRRSNALSDGVMSELEGSEVNTALSGTTTGIVNDESSSQQQQQQQQQNQNQKQYQNDDNDNDNDGQQRHAHGHAPSTDLDGGALRHAFIPNWTSSQFEGFVAEIAELTDLLAEREDAVNRKLDVYKAVWRHVLDVERRFWPHVGVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1J1</accession>
    <name>A0A1C1D1J1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF803 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_02764</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1J1"/>
    <dbReference type="STRING" id="86049.A0A1C1D1J1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02764"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04689"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="538"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="600"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="650"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="712"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="749"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="772"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="813"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="854" mass="93585" checksum="3D01992C81E63249" modified="2016-11-02" version="1">MENVPPQVWAVAHTLIARNETSNSTSAATDSATANRPPVYKAVGLSLAVASGLFIGTSFVLKKMGLLKANAKYNEEAGEGYGYLKNVWWWAGMTLMIVGEICNFVAYAFVDAILVTPLGALSVVVTTILSAIFLKERLSFVGKVGCFNCIIGSIVIVLNAPEQSAVADIQQMQHFVIAPGFLSYAGVVIVACTFIALWAGPRYGKKSMLVYLTICSLIGGLSVVATQGLGSAIVAQAGGKSQFNQWFLYVLLVFVVATLLTEIIYLNKALNIFNAALVTPTYYVIFTSATIITSAILFRGFKGTAVTITTVIMGFFQICAGVVLLQMSKSAKDVPDAAVFKGDLDQVREIAEVEQPETEPKADAIRGTAALIRRLSASRQKMEQEEARRLREDTLKDQLEPLRENEIVEWDGLRRRKTVLGEAGAPVRRNTVRPPLGMSHFPQPDDEEIEHGPSFFENLRHRAQSVIRHPTPGRHQDMPEDSLRSPIHPVALTDIKVHSSKSESPIVPYGPGSYEDAQERIYGLPPGQLQKERAVTIAAQPSPRSKPLPAKPSSSPSLRPAPEARRQFSFTNFLRPGSRTPDIDSTSSRPRLSHRVSSNEQRRAFKNGSEEERLGLVKGDSHVALLEHDSPRSPERPAQSMPYAPANPHSQSSSTSSVDDYYRYQYPSPPQRSLSYSDEVDGWQMTSTESPPNETISAAPPPVTTSSRRRPSPPTIYQPPPLITRSSPTSANDDRAIPGTMVGGGSTRGRATQAASDHFPSSSTSPPRYTNRHPDTGFRRTDGDDHLPRVSEDARVNDAYEYGLARTESPEAEATRRRFEEQSKREREERRQRAAGRRQSWKPTSPGAAGGSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D259</accession>
    <name>A0A1C1D259_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D259"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02770"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04970"/>
    <dbReference type="OrthoDB" id="4158875at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="656" mass="70046" checksum="536B5417E77B6296" modified="2016-11-02" version="1">MFMWLKCMITSNASASASGKNDVASPLGLSQPHDLESVQERPGVCQSHHPRPSIVLRDLHRPTVETRRNSLLKRHELRVRAAPPAVLGSTASFGAEKPSVEALVSRFEEAIPQHRPGEEEIQSIGQAIRSKLSAGSPTPSPSLRASFPNVASKPSRIKVKVSAQSISIIIPEGSKLPIIATVEAAGHIELDTQMSAPQAGESGETSGIHTGKSQSRRTSRRNTISEGYVNQASENQAIISKINLPFLPNRGKGRLNVSEASIPAPKSSDISAQGQVFVSHEHPGGTVVEALHDHSERSNEAVVNTPGATEPPAKLPRDEHSQPADTPSDPGVAQETAPDDPKKASVPTTRPGVPLFTQSESAVEIIAEPFAKFGPTEARSVPAIRIHRPSGTVMAASVGTTAMNSAKVPATPTQSALEQSPAAAGTAPLNTLSTTVAAIPAPANLPVDPSNVSNAIGAATSAVSLPSLPVGGKVGKRKRVVRKTRKLVLRRRVLAIIIGRDLANVVHPQLNAGANVAGSVPLPVDGPSDLVSSYTSRTERKRDFRRRQLDQRIAAARIHAEAEEIHRCRMCRGLTRTMSLRRYHRLQLKRDRPDMNTLDRRATAMSRVAVFKCKCDRRLLGVANEVAVPDAAPSQHFRGPTAMEPPLSGVEAAQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C684</accession>
    <name>A0A1C1C684_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT43979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C684"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00077"/>
    <dbReference type="OrthoDB" id="4161467at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT43979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="910" mass="102056" checksum="25BF2543AE149573" modified="2016-11-02" version="1">MEVRCPGCKKRQTLAPTCTTCAYVLFEMPDSPVRGNNDQSTVLDRSSSTGLESAPSPSNLSVVTGLEHIHESEYVLAPTRRESSESLESWHSAQSAPRDELSQPLMQPPKLELDVRAEGETQRATVPKSISEGTRIASKDPTKPIRLSPKANDSLARTYARIEAFRAERAAESAAAQAKNMAALAKALAEIRGENDSSQARVSHSTPAVQTAPSAGAGYIGPQAEPLPEDFARQLAALSKPYIDDPFGEYDQDAEASHEGGPAPRLIPPPQPSGESYSAAAQKIAAVVKPSNNGKQKLPECTPDNPDVWPFDFYEFGSQKEGHSRQKRFGNHRCACGGFHPEEHCFLCRQMLEVWRRKGSGTGNCTKCGRKGHVVADCGYGEYRDNPSNPPLPPALQRYARPWPSQHSRQPLPAYYYEPRNRRPPSGKPPLRGRFKDGLTCGLLDNNFNLTWSLENAYRMASGSKGRLPFYAKKHGDPQRPLKKAPAETEEKSSKSDEGQKQPKKSQTVDEQGFTLVNRGSKSADAGFGGLNNVPVGLPSPGYRNDSLQWFRSDFEDAMRKCLEPFHARYIGTLRGKFANDKALLASATQNQAIQASVRQVLATAWEVYKMYIPFWTPSKDWTLPSCLDAWIRSEKTRLIDEACETTRERMVDVENFDWEDFSWDNKVQWSDIEVGDEYTPTESRNPQLEPLSEEIAGLQMQDWADHTVWQLRDSVQLEHRHYGSEKKADAVKALELFKRPLEATKNRPTDVGKICEDYDRTWDEHSKFLWVKAWAIKDGSINVTLVSWEHQRGLILQSFDDAEKKYAQTRACAFPKGEKGIGHVLEAVAGKDSEVVETLLGAHLPARDVRGCLIPRLAYSRKFANRFRELQKRRARDQEQRQSANMPVVNFNSEDLEEIAETKMYNDQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6Q0</accession>
    <name>A0A1C1C6Q0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">crn1</name>
        <name evidence="12" type="ORF">CLCR_00596</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Binds to F-actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6Q0"/>
    <dbReference type="STRING" id="86049.A0A1C1C6Q0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00596"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01083"/>
    <dbReference type="eggNOG" id="KOG0303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990819">
        <property type="term" value="C:mating projection actin fusion focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000197">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="11">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="140"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="421"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT44148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="550" mass="60609" checksum="57B54D548CE79DC2" modified="2016-11-02" version="1">MAGRFVRSSKYRHVFGRPTRKLRCGKEQCYDNLRVSKNAWDTNLVKANPEYLALNWDSSGGGAFAVIPTSEKGRLPERIPLFRGHTAVVLDTDWNPFNDSLIASGSDDGKVFLWRVPDDFTLHIDLPADEIQDIAPVGKLSGHPKKVGHVLFNPAAENVLASAAGDFTVKIWDIESGASKLSLKVGEVIQSLSWSANGSLLVTTSRDKKLRIWDTRQEKPVHEGAGHAGAKNSRAVWMGEHDRIATTGFSRMSDRQLALWDVRNAQEPVDGFQMLDSISGVCMPFWDEGTQCLFLAGRGDGNIRYYEYEHDRFEYLSEYKSADPQRGVAFVPKRGVNLHENEVARAYKTVNDSYIEPISFIVPRRAETFQEDIYPPTTGLKPAVSSKEWFDGADGLPPKISMESLYEGAGVKEIPAEEVKPVKKAPETVKAVEPKQPVAEPASEPTPAAIRSPPPSMKEQGATMASAADKFKDTEPAEQVDEESDFEEVEKPVERTSATKPAALSQKEKLAESPAPPAGKVGEDVEGTESAPKHKVPCYVVFFNIPADIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6R6</accession>
    <name>A0A1C1C6R6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Component of the NuA4 acetyltransferase complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_00705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6R6"/>
    <dbReference type="STRING" id="86049.A0A1C1C6R6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00705"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01093"/>
    <dbReference type="eggNOG" id="KOG3001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRG" evidence="6">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="189" mass="21911" checksum="18676869AFA89D2C" modified="2016-11-02" version="1">MYEQEDAFYSRPSIRINVPDHLKNLLVDDWENVTKSLLLVPLPSQAPANYIIDEYFNEEKINRRLGSAEADILEEFCAGLKMYFEKAVGKILLYRFERSQLAEVRKLWESGKYKDWEGKGPGDCYGAEHLTRMIVNLPEMIAQTNMDAEAVSRLKTELSKFSTWLSRNSSKFFCAKYEKPSAEYVESAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6X6</accession>
    <name>A0A1C1C6X6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">54S ribosomal protein L24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_00644</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6X6"/>
    <dbReference type="STRING" id="86049.A0A1C1C6X6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00644"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01145"/>
    <dbReference type="eggNOG" id="KOG3278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="50272" checksum="38E1852B289A41F0" modified="2016-11-02" version="1">MAAPTQITKLPEVLRSPSTIQYFAYRHKVKHSNPYFKPRFTFKLEDREHTLLAENKWRHTDPLMPPYPYGENMHFPEANFGLYGGATVQSGSKISKGRNKGKTLRHWFPNVRVETVRSEALGRELKLPITARVMRTIKKCGGIDAYVTGIKPARIKELGLLGWKLRWLVMTSPKYRVKHEQQLQKYNLPKHYSLEGTFEDAWNDENVRTKMIEQQEAAWQDLRQAAERFEKHVQRYWVDNGEKESYEIPKLESLNRGSPYTLSLPEQLEKPDVVEGRYRRVRTFNEHLTPATRAQLAAEERGSETGGPAEPIGVSDDLSARVEDRIEGITMSVEAQYLGVDPTRDDAQSMEMRLEAVKQMIRNHVQESEAEVSTVRADKELDDKAEILLANTAEDHVAKIDQEVVERNAEQHLEAAREEMKKDQGPRRKRTSQKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C708</accession>
    <name>A0A1C1C708_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LPXTG-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_05991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C708"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05991"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06962"/>
    <dbReference type="OrthoDB" id="5426678at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650653" description="LPXTG-domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="39522" checksum="F7F89E167DD85D61" modified="2016-11-02" version="1">MLTFLLFFATWVSRSHCLEVTNTSLCADACNGPSLTYSSDLSCSDDEYWNTADGVLFRSCLDCESTSSAESGDTSTPQNNDLYWFLCEGGAPRYLARADRTVNMKYTLQFCMFQGNGSTPNLPQCEADCAGLYPVLQTSWFSPEPAEQYAYCSINDTAFPTYASTCASCLLSDEGSVVLGNFLNTLQSACDNQPDASLGETIPLQRALFDTATVGTATATSTADSSTISATTSSASSDRATTGTVSTASGSAKTPPPAADPINTGASAQETSQSSSPGISPGAAAGIGIGCGLGAIALAAGLGWFFLNRRRRLRRGLSPANTFQYQESKSALLSVSPPQPVPLYAQQLASRELHEMDGKQSKTWTSELDGRPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C712</accession>
    <name>A0A1C1C712_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="6">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Nucleus</location>
            <location evidence="2 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UTP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C712"/>
    <dbReference type="STRING" id="86049.A0A1C1C712"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06193"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07023"/>
    <dbReference type="eggNOG" id="KOG3237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="277" mass="31186" checksum="25506361F7DD0E01" modified="2016-11-02" version="1">MSSLRNAVSRRPHKERDQPAARQKWGILEKHKDYSLRAQDYNLKKKKLAQLSQKARERNPDEFAFGMIRDGHAGLGKHKSKHGDGDAKGIVTGRPLSHDAVKLLKTQDAGYLRTVAAKGRRELERLQEEVGMDAVSLGKGRLGKKTVFEDDETAGAPRALKRGLDGQVKQDSRVGDEQGPHVEESEVAASIEDQAPKAKSKKALQAEKDALTRLKAERKRRKRLQEMRVAKLEALKKRQREILVAADQLELQRAKMARTVGGVNKDGVRFKVRERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C853</accession>
    <name>A0A1C1C853_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ribosomal protein s5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C853"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06220"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07395"/>
    <dbReference type="eggNOG" id="ENOG502S4T9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="514070at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="268" mass="30088" checksum="64FBC465AFFCB132" modified="2016-11-02" version="1">MPATTRSKSNLQQTHLEDFENNPEEEKATTSKTRRQDTSKSKDTTARAKRKQPDDEERPPKTSRPTKKQKETHDEASIKPEEGAEDNRPVIINRAPVLQLWAACVAQKLYPNLSWTTHLSIGSAVSALCAISKGRAIGTIDRPNDDPDKKAEKEKKKRSAEKGADDEVDVMSFKLLLKDGSAIVSGKPQKANEAALNKKYGEAEYARTKETMEEAIDMFEARAKKGELNRTAFHMYEGFRPSVQHGQGGWGKKGELRLEKIRELAEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C860</accession>
    <name>A0A1C1C860_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1753-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C860"/>
    <dbReference type="STRING" id="86049.A0A1C1C860"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06082"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07408"/>
    <dbReference type="eggNOG" id="ENOG502S8B2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3338076at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="35882" checksum="E58D698D926E2353" modified="2016-11-02" version="1">MTLSTGASLITLSMLVNKLAGLYGILALFTGYHLSPFQLSMYIYSTLALILTAYLARHIRKQLPLQCLALAWFYVLDSIINAAYTAIFAATWFLVLAQHDAGTSDKKGPGASTMDDTSGFTDPQLNVSRVEVVATPQPPLAGSGQDAVAAGVAAGGPAGSGSNGALQSAILDSQNMNSIGVIIAMWTIRAYFCLIMLAWARMVIRQHIAYSGSKTGVDYTAASADPQIAENPFAESKPQGQGWQGKLGRTLIAIGRSYWLGSDEDDSWMYGMGGKFRKSGVAGEEGGFMLNNIESGPTERERRRRSGTGPPVPAAGVVPGVPVVGGDKMTLQIPQANNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C881</accession>
    <name>A0A1C1C881_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C881"/>
    <dbReference type="STRING" id="86049.A0A1C1C881"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06336"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07410"/>
    <dbReference type="eggNOG" id="ENOG502T2QC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5355007at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018783">
        <property type="entry name" value="TF_ENY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10163">
        <property type="entry name" value="EnY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="196" mass="20384" checksum="7CEB2B2372EA16FE" modified="2016-11-02" version="1">MEDPTEKPIPCPPSLTASTPKLPPATSQALIAHLRANTNAIPELSNLLSDSLNRTGWTDRVKALALELLRNGKCDTFPELMAEVMRRAKTPKEESGSGSGSATSANSTDKTKEVNGTATTTTTAAGTGDASTAGALSGGANNGNNAIALSKEWSGGPDGLPDVRVPLATVELAIEFLQEQIAEVIEPVRDDDDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8B7</accession>
    <name>A0A1C1C8B7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative voltage-gated potassium channel subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_05963</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8B7"/>
    <dbReference type="STRING" id="86049.A0A1C1C8B7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05963"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07392"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="312" mass="35225" checksum="9DFE5F9FB14789CB" modified="2016-11-02" version="1">MAVRSAFDPKDMTAWDHGINFFDTAETYANGQSEIEMGNALKELNWPRDEYVLSTKIFFGTGRKEPNTRGLSRKHVVEGLKSSLERLQQPYVDIVLAHRPDYATPMKEIVEGFTQVIRNLNLAYYWGTSEWSAAQITEATLIAEKYNLIAPIAEQPQYNAFHRQRFEVEYAPLYQEYKYGTTIWSPLASGLLTGKYNDGIPEGSRFANHKDFFGSTVEQLQKPEGKAKIEKVKKLTKIAERLGGNTTQLALAWAAKNPNVSTVILGATKVEQIVDNCKALKILEKLDDKVMEEIEEILDNKPAAPANFGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8P8</accession>
    <name>A0A1C1C8P8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Subunit of DNA polymerase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_05433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8P8"/>
    <dbReference type="STRING" id="86049.A0A1C1C8P8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05433"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07583"/>
    <dbReference type="eggNOG" id="KOG1929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="251770at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17731">
        <property type="entry name" value="BRCT_TopBP1_rpt2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059215">
        <property type="entry name" value="BRCT2_TopBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="104"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="304"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="402"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="686"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="788"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="706"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="891" mass="97107" checksum="08B3A2A608CC5D31" modified="2016-11-02" version="1">MPRQESPESAEQPLQGVVLCFTSIGPEDRTRYADIAIKMGAEHKLDLTSDTSHLIVGSTDTLKYQYVAREREDIKVLVPDWIEAVRDLWINDLPLDLDALATKYRVPTLAGLKICITGFDDLVFRAQLQNNVKQNGGEYTGDLTKDVTHLIAAKPEGKKYEYGMQWQKKVVSLKWYKDSLERGMQLDEALYHPTLPVTEQGVGAWNRKQRPSPQLGKRAREETIAPEPSRKLRRTASVRLGSQNRDMWSDIVGGAGFEAPTDGRPRLKPSISMPSLRRPDRPAIVAEDVRNDRGNTGSGPGNTRSEGFLAGCHFMVQCLDQKKRILISLGATIMGEDETQCSIEPSKLFIILPHNVAAAGPVPEDVIPEGFQVVSELWLEKCMIAKSFIAPESYPLGQVIREPSTSLRDLTINVSGFDGIENVHIIKIVTLLGGTYAEAFTSAISVLVCRATFARRDKLELAHHLGIPVVTEEWLWSTMKDQAKASINDHLLQPQPSHVAKNDAASATKAPTGDHVQLGTTFLQRKASNGPARRQGRAQPADKRTRPGAVTVSPKRSGTPVVVHQGSSDVAHGTDVAGVAGVANGPEIEVSSKRTSASEQQSDTQDGLYIDGKCPLRELPPTSARRNVQAVEHTKAPIRSLDGASSVGEQKAKENTQGAAEVAAKLTDVEAINGAIRDILNERSNQKAANNKVSDEPRKKNNRLVGRALSNLSNSSSTSNVRASRASSVGSVNTDGIGSELPTKQLGEHQGGESTSAAEKRSFSLTGRAKTPLAGLNSAAYGMDDPDLVRPAGFHTEQEPAPRMTQLGYEDPEEAILLREKLAASRQKRSKNPGDNADEDRDERAKPALTRRKTADRKIRDDDLLAIANTGWGSGRRTRHKQRSPPGINGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C997</accession>
    <name>A0A1C1C997_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C997"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05631"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07781"/>
    <dbReference type="OrthoDB" id="4154207at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="641" mass="69858" checksum="F3095C7CA2E20060" modified="2016-11-02" version="1">MSNTLEGSDNELLSACESYPDMQAAPGRGLETRVSALISQAFSASAVSVAPSNLMQSQTSNALGAGNATLEPSFTVMEGAPSQPSVDLSPLRTHDDRPPKPDVLYNSTVVVPDHLREPITTNMQEIVLSRHQQVELGDEGNGGLLQSKLPAFPQTILAPIPATTEHKIPELGPCEQSQSNPKRLKLQMLLNPPHCPISSLEHAGHLLPGLAEVGFTIHPSREVGNIKPLPDQTYAAAANIKRKRSPRTRSPVPRTAKTNQRPGRKYENQWRIGQAPTAGLRDSKEQTNFDRVLAAVSGYYQGNADGTWKMALHNNASEYDGKGLTEAIGASIIMAAGLIAAGQAPDATQILNRTLPLAEVMLLSQHPQLCYWLTEVSMDTSQTVAGSVRRAVKAQFTPLACRLLGPDHPISLVLRMPLTMEQQVRMRREAQAVAHDCHVRTFGKYSYQTMAHQWYWGRITAASGQFDEAVRLLKELTQNFERLYSTPNSAVAITALVEQARVMVASGDAGVRVECLLGDALRRIDILCSAQSLDKPILDAAELRLREGGLVFARLAALRALGRVHAMRLNLSAAVLCFEQAMTIARAELTEQSSVRKLCETDLEVTRMVVLERAMGVLWVEDPTSRLPPVSSIISLVPIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9F9</accession>
    <name>A0A1C1C9F9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9F9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06496"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="75" mass="8196" checksum="62D801321F7D2779" modified="2016-11-02" version="1">MFYTREGQDGSSKAETKCIFPKVAGSKVARMALELAPQEHWPWLIQSLVAVETSCAGELEAHMGVRTGEAVISME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9H1</accession>
    <name>A0A1C1C9H1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_05661</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9H1"/>
    <dbReference type="STRING" id="86049.A0A1C1C9H1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05661"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07793"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="12">
        <location>
            <begin position="3"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT45127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="601" mass="67366" checksum="1EBFFE3A5EF35C0C" modified="2016-11-02" version="1">MRACDACARLKLGCDLDCPCETCLSYGLECTYTRISQQPEADSTTEPTSATIANDPSPPAQIHSPETPPRPKTLSRQERSKISLAFLLNYVNPATTTMADAYGQETEKEGADVAPSSTALNGISGGDLGASASIQQLIFDEFVAPFDAGRMDDVFISYLFPDSEDFPGTGHDANWHMGWQGCDVPTPFATPHAPDPFSTLVDSLTHFTLSLPEGHPERALNDRLTRASALFSNKNVERFIGHYFRDYSPHSPILVPGTFRISSASPHLLIIIIVTGAMFSSSPGDMELARGILELVELYVFSNQDFVKLLQAPYHAQYTNDVGAWDALQAAFFITQIQLREGSLAKRKEARTARFEEIISGVHALGLLQTRNSFFHAEPPLPETFQWNQYGDSETKIRLVCGVFNLDASFTILYNMTPRLFAEEMEVDMPCPAEAFFADSAQDCYQVSLTEHGIQTLHVSELCNAFLQDTWGEQLRTSMLSLSLLHLFTLILALLQTLWLSPYRPRKWQLMQRMAVALERWRDVWDFQNTKLTPRQRERFGFLKTAPLEFWQIARVLVKKKATRLDRAVDQSNLYAANNGRYGSCLQCAQDLLQKVDKEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9L0</accession>
    <name>A0A1C1C9L0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of mRNA-decapping protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_05566</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EDC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9L0"/>
    <dbReference type="STRING" id="86049.A0A1C1C9L0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05566"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07871"/>
    <dbReference type="eggNOG" id="KOG2585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="7">
        <location>
            <begin position="273"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="6">
        <location>
            <begin position="440"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="688" mass="74792" checksum="19708DEC599C6C4C" modified="2016-11-02" version="1">MASDFIGYTILVTLQNPPNAQIQGVVADVVNQKLFLQNVLLRWNGRRLTSYAIDSSAIADLEVSPTQRSPFEEQETLTPVAATSNVAPIRPAPHPPQNAPTFIDPAIVSYAKPPTKVPTVPAPTSLVQPVSPIMIADGVVSNSSQAPPRNGNMGNSSVSSIATAVATKAEKRNTPASATLTEPFDALTLGSEVAQATPVSLANKENNAHTLPSRTGPGIIDMKDINGPLKNQKKTGKGKGWRQTPLIEEVPRQPKKKAQRGRKVAEDLNGWATEDATDIQDMGDFDFESNLSKFDKRRVFDDIRQADTTAEADRLVSFNRRARPGTNGGRNLHYTENVLDAPDGKDRDRWKSEAGETEDDLLDHDGHYSSGRGSRRAASRRPLQSRKGSVIPSLLERTESPRPLTRLQTSSPLNGSVSGIRASFKLQNNKPCHCLSPLQMLEIEQLCTSEMGLTEDMLSENAGRSIAMAVLKLPDIRSVVFLIGNHKSGARAIAAARHLRNRRLRVTIVVLGGEREEMLLETMKKQLAIYKKGQGYVDRWDEYQAKANAGGPAPDVIVDALLGVHVTFEELRTDDQATVLEMIRWANRSSLVVSIDVPSGLSATTGLLTEVDGQFLVMNSKHIVSLGAPKAGLLHAMAIDGLAEPPWQVWVVDIGISAAAWQKHGSRRKHGVDFGAEWVVPVKFVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9N8</accession>
    <name>A0A1C1C9N8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycine zipper 2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9N8"/>
    <dbReference type="STRING" id="86049.A0A1C1C9N8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06279"/>
    <dbReference type="eggNOG" id="ENOG502S756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008816">
        <property type="entry name" value="Gly_zipper_2TM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF10">
        <property type="entry name" value="RICH PROTEIN MS8, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05433">
        <property type="entry name" value="Rick_17kDa_Anti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycine zipper 2TM" evidence="2">
        <location>
            <begin position="167"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="228" mass="24261" checksum="631C9EAF32392EBC" modified="2016-11-02" version="1">MSGPYDSYGGQGYGSQYPQQGYGQQQGYPPQQGYDQGQQYPSQQGYQQYPPQDQGFGPPRRQDSFGPPQQGGFQHGQQTYQFGAYDASNPQGNAGYYGQPQQQQYGSNDAYAQNQAYQQQMSHGGQGQQSQGVPAQAQNHQFSPQSSDPNAPNYDPNAPPMTEGERGLLGAIGGGFGGHFLGKSSGHGFLGTVGGALLGSVAEDFLKDKKKKHHGSGGSSWGGSGSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9Y8</accession>
    <name>A0A1C1C9Y8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9Y8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06154"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07936"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="268" mass="29966" checksum="0B0FB9ECAF0E6AC2" modified="2016-11-02" version="1">MPITFINRSTHNFHPPTELAAINAHHAHTRHQKRRRAIEDAARRQNARILSYVVTERERESDDVAAEGDADANDQVYSQQHAANSNTTDALVFCLPPWQRPRQIGTLRDDPFWTLPVANTHSAMTAFDYHFQVMCPLALGLGNYNQRQHQIMRLHVLETAMYCSSMIAFGLVMQSLHVHCAARLSREAVHHVNNAVGGLRAAVGNLDPRVGTSDIVLATIFPMAVVYRMLNDYDAFNAHVEGVRRIVALRGGLDNLGWEGFLKISAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA03</accession>
    <name>A0A1C1CA03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase DBP10</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent RNA helicase dbp10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">dbp10</name>
        <name evidence="21" type="ORF">CLCR_05435</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA03"/>
    <dbReference type="STRING" id="86049.A0A1C1CA03"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05435"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08002"/>
    <dbReference type="eggNOG" id="KOG0337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="110"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="350"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="628"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="830"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="870"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="839"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="870"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="910"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OCT45370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="942" mass="102959" checksum="884FD516A6630FD1" modified="2016-11-02" version="1">MSFRSGSPARSENELDIGSALFGGDDGSSDDRNGHVQGHDLDVMAEGSSTDDEAIIAAQQAASNRKGTNLKGRTVKKGGGFQAMGLNANLLKAITRKGFSVPTPIQRKTIPLLLNDKDVVGMARTGSGKTAAFVIPMIEMLKVHSTKVGARALILSPSRELALQTLQVVKELGRGTDLRSILLVGGDSLEEQFSAMANNPDIIIATPGRFLHLKVEMNLDLSSIRYAVFDEADRLFEMGFAAQLTEILHALPASRQTLLFSATLPKSLVEFARAGLQDPVLVRLDADSKISPDLQNAFFTLKSSEKEGALLHILQDIIKIPTRSQLVSSNETSTSTAKAGKKRKRQEAETASDSTNKASSNPFSTIVFTATKHHVEYIANLLLLAGYAVSYVYGSLDQTARKSQVHNFRTGQTNILVVTDVAARGIDIPVLANVINYDFPSQPKIFVHRVGRTARAGQKGWSYSLVRDADAPYLLDLQLFLGRKLVVGRAGGGSVDFAQDIVVGSLRREDHQTSAEWATKALETDTDLSALRNVASKGEKLYQRTRNSASSESAKRSKQLVSSPGWAELHPLFNNQEDDMEVERGKMLARVGNFRPQESIFEIGARRGGRKNNEEAVDAIRQIRSGLENRKQKAADAAQARSAPEDDVASTQAVPDWHGESEDEDDGDHPDADAMSEASSTDLEVTFSEPYAKKPKSNAQSLAKSRSGPEGTNFRDPSNYMSYLPTTQDLTSDRAYGVHTGSNTSNFIESARSATMDLGADESSKTFGENRQVMRWDKRHKKYVRRENDDDGSKGRKLVRGESGAKIAASFRSGRFERWMKSNRVGRMGRVGEEEKNTSGGGMAAGGGNGNMRGKRFQHRTLRAPKAPDKLRGDYEKQVLKAKGAKDRADQNPGLGSATAPTRNGKGKGGKGELRSIDKMVKERRLKEKRREKNARPRRKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA10</accession>
    <name>A0A1C1CA10_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heterokaryon incompatibility protein s</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA10"/>
    <dbReference type="STRING" id="86049.A0A1C1CA10"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06183"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07949"/>
    <dbReference type="eggNOG" id="ENOG502S8GV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650662" evidence="2">
        <location>
            <begin position="25"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="3">
        <location>
            <begin position="6"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="283" mass="31401" checksum="3647B4F38FDF0BBB" modified="2016-11-02" version="1">MAEAAGLVVGAVSLAGLFTNCVDCFEYVQMGRNFGKNYQRCLLKLDVVKLRLSRWAEAVNNSSNSHQAAIDTTRKAQQVGEILGEIIELFADAERVSAKYKAKASGDELVVYNPENELEPDILSVHRKMRALALKRQKRSSFTQKAAWALYEEKHFRRLIEDVTTLVDALLELFPATQERQRQLSAEEAEEMREERRLDALEDATEGVDQLLQNSVQHAIASQSGHTFSENLAMDNSRVRYGDEHASGVPGAGAGHRYGGNTVQGSSKVHYGNRFGGKSVLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAB3</accession>
    <name>A0A1C1CAB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06403"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="119" mass="12605" checksum="795F08E9228B7464" modified="2016-11-02" version="1">MPKRNPMTKERRLAHPIYSVCKQKAGRDMSTREGGLRAGSERWGVRNANANANPNANANSNANPNSNANPNSNANPNSNANPNSNANPNANANANTNTNARDTTSGPSGARSERRPVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAC8</accession>
    <name>A0A1C1CAC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">amyS</name>
        <name evidence="8" type="ORF">CLCR_01512</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAC8"/>
    <dbReference type="STRING" id="86049.A0A1C1CAC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01512"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03411"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11318">
        <property type="entry name" value="AmyAc_bac_fung_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006968">
        <property type="entry name" value="PRK09441.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006969">
        <property type="entry name" value="PRK09441.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="1"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="489" mass="55321" checksum="502DCB23AFE0D862" modified="2016-11-02" version="1">MGVSHIWIPPGCKATSAQDVGYGIYDLWDLGEFDAKNDGKPSRTRWGSRAELESLCAKANGLGISILWDAVLNHKAAADAKETSWGVKVDPKDRTKVFSKVHELETWTKFTFPGRGTKYSDMKYNWTHFSGVDYDSRKKEHGIFKFIGEGKRSDWAPDVSKELGNYDYLMFADIDHSHPAVRTDIFNWGAWITSMLNLGGMRLDAIKHYSLSFLADFIAHLDATTPEGSKLFYVGEYWDADTDVLEKVIKRFHGRLHLFDVQLVYTFSDFSKGRKHDLRTILDGTLVQRDHAHAVTFVANHDTQETQSLAAPVEEWFIPLAYALILLREHGGTPCIFWGDVFGNHGPRPRLPACGGKLARMIVARKLYAYGPQREYFDSSECVGWTRLGHKSRSNGAGLAVVMTNSWDRRSKRMFVGHRHIGEKWRDVLGWDDKEVVIDSRGFGTFPVGHRSVGVWTHDKAPEFDKISHFTFPRLGNSAAAPDPRLLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAF5</accession>
    <name>A0A1C1CAF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_01622</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAF5"/>
    <dbReference type="STRING" id="86049.A0A1C1CAF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01622"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03416"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000056">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="8">
        <location>
            <begin position="8"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="9">
        <location>
            <begin position="198"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT45505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="340" mass="35995" checksum="E104526E47C07305" modified="2016-11-02" version="1">MPYSPDSTVAFIGIGVMGYSMAANLRSKLPSSKLLLICDVSQTLLDKFQKENGSKGPIEVVPNGYEAVQRANTVITMLPTAGAVEKVYLDEKSGVIQGAIDASKNGSPQKKLIMECGTIETASILKVAQATKDAASKLAAGATLDFVDAPVSGGPMGAEAGTLTFMVGATSKEPFEHAKEYLQHMGKKDSIFHCGDVGAGTAFKVINNYLSAITSLAASEALNIGAKMGLDLKLLTDVINVSGGQCWVTSQSNPVPGIHANAPASRGYEGGFRIELCKHVLEMGNSLAKMVGARTILDKPTLAAFDEAMSDERYKGKDARVVYKWLNDQDVEKVVNGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAH1</accession>
    <name>A0A1C1CAH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_01747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01747"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="118" mass="11755" checksum="6EFCF23490BF51A0" modified="2016-11-02" version="1">MAFANLAQKAAQWMVNSPAVISVKLSLPALPLLQSSSLTVPIDPAVGNTAQGVKPAPKAAAMQEILEDVAVSGPFAIAQIAGAGDNSLGVTSRIAHIGVVAIAAEGATAAWIKSNGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAJ9</accession>
    <name>A0A1C1CAJ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_01625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAJ9"/>
    <dbReference type="STRING" id="86049.A0A1C1CAJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01625"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03384"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="167"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT45472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="37570" checksum="86C3C26291B04983" modified="2016-11-02" version="1">MTVVAADFVPIVPYTTTTLKIANGQRYDVIVEADQIPSSYYVRAVIQSGCPSGGANSGLGTANAVINYEGATPVTPINNTPITNVTANICQDEPLASLVPFLQKPGGSATAFQASASTIPAGSVTSVATNDDGTVFQWYINNAVINVNYSQPTLKTLAEGGSNDLISNSIILNQANTWVYFVIQNQFFASHPMHIHGHDVSVLGTGVGTFTADMISTLNFENPTRRDTVMLQGSAGPGNPAGYTVIGFETDNPGAWLMHCHIAWHVDGGLALQFVERPGDITTGKYVGDDFKGECSALQEYESSSPQGAKLSGQSGLKARGYSDELDFGLWNGGAKMNIEQYRKRYAHRHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAX2</accession>
    <name>A0A1C1CAX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative peptidase a1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_01455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01455"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03520"/>
    <dbReference type="eggNOG" id="ENOG502SK68">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650671" evidence="3">
        <location>
            <begin position="18"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="43"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT45611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="704" mass="76234" checksum="747B3454136B3B65" modified="2016-11-02" version="1">MAALVGASLLFAAVAAAQNSCSIVPLYVDFHDRAVNGGVNIQYGLFAGIGFPGSQNQSLWPSLSNNETTVSSLDYCTNSPFADCLNHDHGFYSPELSENYSSVASYQPLDEYGSIPATIVETALDTFNVFTHYFDPSPATITRVQNFPFTILSNYSSSRTPWFGPAGLMGLGPVSTLLEHLYNNQFISSRSFGLYMGTEYEQSNGAVNGSLTLGGYDSGRFEGVVHNYTVSQPRADAAHSPFKVSVQQMTLTDESNGEKTDLLTGAFDAHITTSQYQLSLPDNVLQQFSDATGATPSDDDLNVYRLPDDFNSTLTITLDSGLEITYDADWLKNVSNNSPISTDTIPDSTTDGTINLLGSAFLSNVYLIANYDSEPPTFHLAKALPHAPYVFTEPLCPNTVPTAAAQTKISSFAASGMAGAIVGGVVGGIGLGFAIYWLFRKCMQRRMWREKARQSMKGKGMDSESTVGGTKWAGGKAQGSPSTMASEIERGNSSEMATFAFDFNSQQQQHQQQQHQAYATYLDNATQQPQPQPQPQPQQQDQNTSRLSRTYSQFVKQMAHENVGLNTAPPQSGTHAPQYARPFSSDSYETPITPATGVPLLFSSSRPGQSSEPVIQTSKHGPFRPLTLTHSNVSEPDATSTFPFGEGQARSREDHAFQARQAKLKGLNVQTEFAPPPTAVSEKMARKAAGREGGKRKKMFSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBB8</accession>
    <name>A0A1C1CBB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome p450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_01458</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBB8"/>
    <dbReference type="STRING" id="86049.A0A1C1CBB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01458"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03696"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="589" mass="66664" checksum="652B3B5962EBFF02" modified="2016-11-02" version="1">MADHSDHPVIEAKPAMTSLILLVVVCCVFLYFSYRRLLPKPILGIPYNESATRSILGDVPEMMSYISRTQEIWPWLVDQTTRHQSPIVQVWGRPFSKPWVVISDHRESQDILLRRTKEFDRADFTTDVFTGLLPDMHISFKSSEDRFKTHRNLLKDLMTPAFLHEVAARQIYTNNEAFVQLWELKARLAQGHAFRADEDIYNVALDVIFATTFGLDIQDSNTVAQLKQLSSTPVSVPQSPDEPIDFPHFSRPAIFEAISVLTESLETSVKAPFPRFAHWVLRQMPYMRKARADKEKHFTTMINDSITRVASGKQAKSSALDDILLREAAAAKKEGRQPVYHSRTIYDELFGFIIGGHDTTSGSDDLTATLSWAVKHVAFAQEAQSTLRSRLRAAYTAATAERRNPTIDEITKIPIPYLDAFIEEVNRTAQLFGATVRSATVDTTVLGYTIPKGTEVFLMQNGPGYLSPPLPLDDSKRSKSSLEAKNQVGQWTPDEADMKAFRPERWLVKKENGTEEFDAHAGPHLAFGLGPRGCFGRRLAHLQMRIIVVMMIWNFELKATPERVSSFAALSRLARHPKMCYVQLERAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBV7</accession>
    <name>A0A1C1CBV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GCD11</name>
        <name evidence="12" type="ORF">CLCR_00442</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBV7"/>
    <dbReference type="STRING" id="86049.A0A1C1CBV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00442"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10063"/>
    <dbReference type="eggNOG" id="KOG0466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990856">
        <property type="term" value="F:methionyl-initiator methionine tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="83"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT45942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="513" mass="55445" checksum="A8A13DE74BC86A10" modified="2016-11-02" version="1">MATNGDLPSDDEFSQPGTPPGDENDVDEIEESNQTPKSALKRGTSAAIPEAQVSRPVLPEQPDPKDLEISKLTPLSPEIIARQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELERNITIKLGYANAKIYKCDNPECPRPTCYKSYKSEKEVDPPCEREGCKGTYRLLRHVSFVDCPGHDILMSTMLSGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLNHIIILQNKVDLMREEGAQSHYESILKFIKGTVADGSPIIPISAQLKYNIDAINEYLVTKIPVPVRNFGAAPHMIVIRSFDVNKPGAEIEDLKGGVAGGSILNGVLKLGDEIEIRPGIITKDATGQTVCRPIMSRVVSLFAEHNDLKFAVPGGLIGVGTRVDPTLCRADRLVGHVLGLRGQLPEIYMELEVNYFLLRRLLGVKTADGKQAKVAKLAKNEVLMVNIGSTATGAKVMGVKADAAKLTLTNPACTAIGEKIALSRRIEKHWRLIGWANIVAGNTIEPESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC12</accession>
    <name>A0A1C1CC12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">IDH1</name>
        <name evidence="14" type="ORF">CLCR_00453</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC12"/>
    <dbReference type="STRING" id="86049.A0A1C1CC12"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00453"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09971"/>
    <dbReference type="eggNOG" id="KOG0784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045242">
        <property type="term" value="C:isocitrate dehydrogenase complex (NAD+)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="52"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT46045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="387" mass="42301" checksum="DC83A7FC58D482F4" modified="2016-11-02" version="1">MSLARSSRGAQALFRAAQRASRHTTVSPFLARSYATVESDIFKPTKYGGKYTVTLIPGDGIGAEVAEAVKTIFKADNVPIEWEQVDVTGVDSGDKHSEDLFKESISSLRRNKLGLKGILHTPIERSGHQSFNVALRQELDIYASVVLIKNIPGLVTRHKNVDLCIVRENTEGEYSGLEHQSVQGVVESLKIITRAKSERIAKFAFSFALANNRKKVTCIHKANIMKLADGLFRNTVKKVGEDYPTLEVNDMIVDNASMQAVSRPQQFDVMVMPNLYGGILTNITAALVGGPGVVPGCNMGRDVAVFEPGCRHVGLDIQGKDQANPTALLLSGTMLLRHLGLDDHANRISKAVYDVIADGKVRTRDMGGDATTHEFTRTILDKMEAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC90</accession>
    <name>A0A1C1CC90_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">srb4</name>
        <name evidence="8" type="synonym">MED17</name>
        <name evidence="10" type="ORF">CLCR_00406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC90"/>
    <dbReference type="STRING" id="86049.A0A1C1CC90"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00406"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10336"/>
    <dbReference type="eggNOG" id="ENOG502QS9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5319830at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT46086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="634" mass="70374" checksum="AC48623CE4F9B68E" modified="2016-11-02" version="1">MAKSNTISLVIPPEPSSKSHALESQIQQIIGQKGHFRHVTERSLLAEIHGKATAPDVAQERPEEELAVDDDETPQKRTERLWERRNQMLERLGAAQNDILCALDFVSWLISQQSVPARHSMSAPLKEAAPIGSLVAKVLEEKPIAPPVRRQLVSVSHGWRSEGFHSASNKLSAASSRLEAEAEHQSQFWKQVADLRAKGWPISRLPRDRKAIGVHFGFAESAPQFRDRGFALLLQAADGSVGLDARSLPKKRRRLAVYVIRNAHKTGAFHFESPRTSETMDIGQQLTDHRDALFEEELFFEICREARLVGNQGITTRATSVGIDVGDYRLLLVSSDEQEAVLNTNNEDDSIAEFVGISLRLLLNVAHEQNLSRRMQKAPPMAIKARTMPEYALLRPILTHLRHRSEARAFWTSIQTLLHAFETASLPTTMSMENSNDAVFASLKMESPNTLLSELMVPAKTSFALKLTTGRNLQVGLATFLGPPLLGSRYETSPIDFGFSKIPSCRHETRDVALASVRHMLLLELVAHAEALTRTDAANAEADKSRHKKWSLSQPHSGELTMYYAQEAVRRMQLSVHTESISLKGSPVKQRTSSSGIVWTWTAAGCFKAEGNATTKEEGTTFDAAVRQLLATDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCH3</accession>
    <name>A0A1C1CCH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01355"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="104" mass="11473" checksum="212F5C3E1821CCB0" modified="2016-11-02" version="1">MVLWLWNLQSVDEGCFFIDNGSSRTAMLSPVRGIVVETWVAEDAGLLNKSPLSPSALPRQRRRSSVRTESNQIGPAEELSTFGDAEIISAAVREIKPIKAPCFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCT9</accession>
    <name>A0A1C1CCT9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative-like methyltransferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCT9"/>
    <dbReference type="STRING" id="86049.A0A1C1CCT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01140"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09245"/>
    <dbReference type="eggNOG" id="ENOG502SIQW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="587" mass="65499" checksum="A5F7C17F91CD404D" modified="2016-11-02" version="1">MEAEISYLSPSEIAQSIKTTQLELAYERALREAERIYEEEQGRALRVQLLLLQHENDDLQQHIEEEEEEHQHMEDTNEELRAQLAEAEAGLQQTQMDLKARTRDLEHLKTEVVALNATSTDATRLLAEKLALARELNTIKPELEHLRSQSFISQKLLSEKLALQREVSALQVELETEKRAVQRIKAREESNSREDTTLIAEIEGLRKELTKAQRDVSKYSAAQEGTMAEMESLRKELAGAQRDAAKHAVRDDTASTAVESLRKDLAKAQRDAQKTERESRKKIAEWESEKEVLEAKLDAFRNKLRSTKEQLLEAQEEIERLQAAKMAQSAELTKARMTGQAAASNSRKRNVARFDPDMTIGTPGNGGPAAKKPRISVNVGDKSTFSITPFLNRTLSILPESPDDEDEPQDMAQKPSSQQVDGEGGVRNQASKSKGTKEKLDKAAATRKPPVPSTKTRARRALNETTNAKANTTTQKPQLAKLVEEDADMESDEGGMNPEENTDKENNEDNSATPRDSTEPSKKPRPLVQRKNIFDEPDMAPAPKIRSLGGGAGLGRINLKAKPVGRGKTLAEFSPLKRDRRATSILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCX4</accession>
    <name>A0A1C1CCX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01341"/>
    <dbReference type="OrthoDB" id="5595137at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650730" evidence="1">
        <location>
            <begin position="25"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="147" mass="15195" checksum="6ED73F8175D9358A" modified="2016-11-02" version="1">MKLNKTSSVAAVLSVLSFNSVVSAIATLTVCTVVGDASVPSSSFQGGNLFTIHIENVPDVSESTICGHSDSDIHSAADSFSTRVTSVIACSTSRVGNDQNFMDLNVRFDKQSPSVQLSALQNGITAAFGSQGVDFDASKCDISGIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD05</accession>
    <name>A0A1C1CD05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD05"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01166"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09180"/>
    <dbReference type="eggNOG" id="ENOG502SQTP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="519" mass="56996" checksum="2334D40D38CE4794" modified="2016-11-02" version="1">MSGLEPLAVVSAVAGILQAYEAGSKIFRQIKARRQAHGALPPTDRLLESLEKGESEVKKAVEEGKLRFGEDFEIGDTATLFALMQITIDVQKALLAGLAEARSDDGVVDFEMCINSCDKARQDALITLQGLFLRRLAAEQKKADHPRSPPEQAKRSQGQSPTVRERTSENMETQRSPPPRLEKRPTDTESTKALKAGRWLLSRRDRSGESSVTLMESTPVMGSPPAPPARASEPETMLQSRRSTSTSTNSTTTRSSTSTHEGPPPSPARSSTNSSSIAPVRRQTTGYTMHSMGGLSAVAGLSMTSDISTPSTVASLKKSGRCCKKTSELRDGKISEALAHSHAPGSQARTYHCTNKKCHFWAPAVQVANVYQLDNSVICHPSGMRYRRIFLAKCHMQQSDATQTVTYRCLVCLFLGDSQAYEGHDRLLSHLASHRRVELGETRLEGPVVFTNKRVECNRDEFDIDFTEPAKEPIRKPYTVTEAMVVPMSRPQAQLQRSASVVSDSPNFALEERILWAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD35</accession>
    <name>A0A1C1CD35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcription activator of gluconeogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_01085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERT1/acuK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD35"/>
    <dbReference type="STRING" id="86049.A0A1C1CD35"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01085"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09092"/>
    <dbReference type="eggNOG" id="ENOG502R1M5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2538135at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="517"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="618"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="517"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="618"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT46435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="707" mass="77197" checksum="B15CA1F0D5927EB6" modified="2016-11-02" version="1">MAASDAEDGHSRSASPEDSGTEQVQENMAEGPGKDTKQQNGAKSTNPKDPSRPRRKKARRACFACQRAHLTCGDERPCQRCIKRGLQDACQDGVRKKAKYLHDAPNEALMPGVGANLFNHSAKLSSSVSGETPSHQQFFPQPQNFTNFQTPSQMPPPLIAERSMSANSFPQQSPLGTNFSSVPSQVPMQSPVIGADQSVTSNLGGTGWPGPIFDEPVMNFDLASMNFGDHYGALEFGMLGHMATNAGETPPSDTATRSGSITQQYRMPFGSFSESPTARQQIYNETILPDWSNGPDPYGAHGRHMAPNAFAIESNATHWTSPDTNGTPGNAVKFEDSPLLTSQGLQVPPSAIEGGPVNQSSGTSEHRNIRQLPPISTPQLKAKSQLPVKALKRPRDPSSIYTIVTQPYPYTSGFHSFIAYLQKRFAAHPSKTLAIAKSLASIRPSFIATTKTLNREDLIFMEKCFQRTLWEYEGFIEGVGTPTIVARRTGEVAAVGKEFQILTGWTKNVLLGRAPNLNVNRGHSGQTPAAGSGTNTARQTGTNTPTQRTAPESENGEKRQQPVFLAELLDDDSVVQFYEDFARLAFGDSRGSVSGRGKLLKYRTKDDEITQNLNAEADARDPDGRNAELRRQESAISRRDLKRERDGISGEKGMQKLGSADGKVDCTYCWTVKRDVFDIPMLIVMNRQRYGSTKLVQVEVSIEKSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD95</accession>
    <name>A0A1C1CD95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD95"/>
    <dbReference type="STRING" id="86049.A0A1C1CD95"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02060"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01233"/>
    <dbReference type="eggNOG" id="ENOG502S03H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9975943at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF8">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="298" mass="32290" checksum="87570658845E1DEC" modified="2016-11-02" version="1">MVHLILTGATGLIGSSVLSHILSLPPTSKPAIDKLSILTRSTSIPWLAATPPPGTPTTNNHTEIEVIEHRDFATYPPELLARLKGADACIWALGVSQNDVSKDEYVTITRDYAVEAAKAFSTLRAATAAAAAAADAGEASETASETFKFVYVSGEGATLHPRPWTPIYGRVKGETERALLDLSKTAQYSPLLSVYSVRPAAVDGANQPWIWDQVLHTKRTAFQRFYLKGLMHPIRWGWAGGEATHSPTEALGRVLVDMAVSEQRGAFDVGVGVDAESEGRTLGNKRLRMLERGQGWWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDH4</accession>
    <name>A0A1C1CDH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cdc18</name>
        <name evidence="10" type="ORF">CLCR_01884</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDH4"/>
    <dbReference type="STRING" id="86049.A0A1C1CDH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01884"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01314"/>
    <dbReference type="eggNOG" id="KOG2227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000547">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="173"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="546"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT46584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="598" mass="65468" checksum="C5F3BBCF6BA55383" modified="2016-11-02" version="1">MAATVLGKRSRKVLDTEDVANVAPSPKRRTRRSVPEIYEDASPESAGQETNTSPVTTRNRRSQRTVQDSPVNLVHNDTRPFDENLPPSDVSTPTAARFKDVFAVTPSTPKHRVRLAGGLLTPRSSRSSTPKSQNVYSRGRQLFTQASNGKIIGREAERSQLRKFIFKALDSKTGGCTYVSGPPGTGKSALVQEIIHESSEQHVRTAIVNCVSLKSSSEALVQLSNAFCSTKSNAKSSKTSLAKLFTTKKANSSMYLVLLDEIDTLLHRDCDVLYSIFEWAMHPSSCLILIGIANALDLTDRFLPRLKLRNVKPQLLSFLPYSAQQISTIICEKLRSLVPDGTAAGSEFIPLMHPAAVQLAGKKISSQTGDLRKAFSLVRRAIDQIEQETLLKVNQEQSITPTKTALSEIRNMGSTTGFPSPLRDQRSVLGQLTFETAPRATIAHVAKIAASIFNNGTISRLSGLNLQQKAVLCSLVASENRRFRRDPYTTPSKSWSKVPTVKELFEKYAALCKRDEGLLQPLKNTEFRDVVASLETLGLVQEASGRTSSLLTPTNTPSRSGRGAMDDKQVVSAVSEGEMRDSLTGPGSDLLLRLLDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDW4</accession>
    <name>A0A1C1CDW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AmmeMemoRadiSam system protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDW4"/>
    <dbReference type="STRING" id="86049.A0A1C1CDW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02006"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01432"/>
    <dbReference type="eggNOG" id="KOG3086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41210" checksum="AE51C231362B99BF" modified="2016-11-02" version="1">MAVREASHAGSWYSANGRQLAAQLDQWLAAVPEKDVLPGVDSLPLPDARAVISPHAGYAYSGPCAAWAYKCLDLSKAKRIFILHPSHHHHLTTAALPVVDAYETPLSKGPLPLDHETIKQLATLSTAVQGRTIKFTTMSQSVDEAEHSAEMQLPYIHRLLQKLYPGQPESSYPPLVPIMVGGTNPATEAALGKMLAPYIADETNAFVISSDFCHWGSRFGYTYYLPDAPSPALSPLILPNGVRGQFTTAKESVNEDVHKMPTLGQGQDLSSRSQIPRSGPQIFESIAHADRACMCAIATGQHSEFLRVLKDTGNTVCGRHPIGVFMAGVEEVERSEREQGHDPGDRRRFKFMRYERSSDAESVRDSSVSYVSAFAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDY6</accession>
    <name>A0A1C1CDY6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDY6"/>
    <dbReference type="STRING" id="86049.A0A1C1CDY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02189"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01402"/>
    <dbReference type="eggNOG" id="ENOG502S8ZR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273230at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9787" checksum="7B3D768A7CA74F55" modified="2016-11-02" version="1">MENLNELYSTARDEFEIAAEETEKKTVYAADDREAAADALNMLKEAFAKALKETSPEVGKEIQTRVGSRIRELENAVKAMEEMAMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEB4</accession>
    <name>A0A1C1CEB4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">rRNA-processing protein FCF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FCF1</name>
        <name evidence="7" type="ORF">CLCR_02090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEB4"/>
    <dbReference type="STRING" id="86049.A0A1C1CEB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02090"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01524"/>
    <dbReference type="eggNOG" id="KOG3165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000019">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="66"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT46811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="194" mass="22518" checksum="34569774F6633AC6" modified="2016-11-02" version="1">MGTHKKTRKFQVKKIIGQRDARLKKNQETGKTTDLKQRKDDDVIREAPQVSSALFFQYNTALVPPYNVLVDTNFLSHTVQKKLELLSTMMDCLYAKCIPIITDCVMAELEKLGQKYRIALRIARDERWERLKCGHKGTYADDCIVDRVMRHKIYIVATNDRDLKRRIRKVPGVPIMSVARGKYVIERLPDAPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEY7</accession>
    <name>A0A1C1CEY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEY7"/>
    <dbReference type="STRING" id="86049.A0A1C1CEY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02561"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02382"/>
    <dbReference type="eggNOG" id="ENOG502S06P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="309" mass="33537" checksum="FBAE419960CCCB76" modified="2016-11-02" version="1">MPPTDPIGVGTDTLPVRNISKSTIYTMIPSMVRSRIPVLTSLRHTARTVVLHGSRVRRGGDGYALSCMETTKEKESYSIASTTDSSRATTPTTRPESPEGSIPSQNPSLTNCPRLETRSGVDWDVALTGVRLWASAKAQAEQGRDSVALRSMHIDALRYMHMALPQDLTPLEVQSLRGSMAPQLIFQAAGPGELPVPRHPNILRQSIAQAVCWLIAGLLLVLPVIMTLLNRLLQFERQHQVTERVISNGVQVTSALGERGIELHQAIVRFKDGRVGGACFDLGSWFMEGIVGGVNDGLDAVAQSRRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF24</accession>
    <name>A0A1C1CF24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein rho2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rho2</name>
        <name evidence="10" type="ORF">CLCR_02620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF24"/>
    <dbReference type="STRING" id="86049.A0A1C1CF24"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02620"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02295"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035841">
        <property type="term" value="C:new growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035840">
        <property type="term" value="C:old growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903139">
        <property type="term" value="P:positive regulation of cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070610">
        <property type="term" value="P:regulation of fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000573">
        <property type="entry name" value="RHO family GTPase Rho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT47135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="202" mass="22401" checksum="B4F3C1E8C494A6BD" modified="2016-11-02" version="1">MAQSQAQQNVMRRKLVIIGDGACGKTSLLSVFTLGYFPTHYVPTVFENYVTDCRVDGRSVQLALWDTAGQEDYERLRPLAYAKSHVILIGFSVDSPDSLENVRHKWIEEARERCPNVPVILVGLKKDLREDPIAIEEMRKKSLRFVSPREGAEMAQQCGARKYLECSSLTGEGVDDVFEAATRAALLTFNGKQGGGGCCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF92</accession>
    <name>A0A1C1CF92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF92"/>
    <dbReference type="STRING" id="86049.A0A1C1CF92"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02346"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02288"/>
    <dbReference type="eggNOG" id="ENOG502SGIR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3355480at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="69187" checksum="3D947B4AB34F3646" modified="2016-11-02" version="1">MVTQPGWLEGYATHRYDWARMSNRPAFYRRIGIVESLFNTDGTDFEGRADLTIHLHVEARSFLTLASLRSRICLVWSIMRQKHVLLSSRVATPIEVFPPGHQDTPSERFYIFEPSQSVESMRDEAIQHMVFVEDHYPHVDDYEFFVHTLNSSRCIDEVKVLSKLYVLPVKAGQDGFFQLHFMFIAGHEIVDGLTSMRWMSDFIDLLNRSEEQLLSDAQKLCATSPIKRLPPAQESLYPPVSGSHARQRWSWLLTRVLRHTRRPPPASFQNPLLRETRRTTATPLEPIFSKVIDYSRTPPLNTYPLRATLSGSSTKRLSNICRAARISIGSGCFALVAIVMMFLEEQRNQSIPAHERLPFVGSFPINPRPFLNGEPTTGKEDSLMLAFSDGITLPFLPSGLDLEGRIRLLGKQAHRQLRQYQKRPRSLAQEIHLDSRSTTQLIPLLYLNTMEYLERKSQPSRRRGWDIQGAYPARLGSPSTCGVSSVGDRGSIISSGKYDTSKTPPRGELIADFRNLETTVRARDGEFLVGVVGDQDRLRLGVSYDGCAIDPDLADRFKTIIESILDEPGPSVSERGGIPQSGNTTEDISTKTDDFSIKGLPRTRDSRPLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG19</accession>
    <name>A0A1C1CG19_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha,alpha-trehalose-phosphate synthase [UDP-forming]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TPS1</name>
        <name evidence="1" type="ORF">CLCR_03411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG19"/>
    <dbReference type="STRING" id="86049.A0A1C1CG19"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03411"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01919"/>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF75">
        <property type="entry name" value="SYNTHASE SUBUNIT OF TREHALOSE-6-PHOSPHATE SYNTHASE_PHOSPHATASE COMPLEX (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="544" mass="61880" checksum="72A6FC9430496859" modified="2016-11-02" version="1">MPASDNVDGIDPEFEGRVLVVANRLPLSIKAKDNGEFDYSISSGGLVSGLKGLSKVVDFKWFGWPGIDVHRNDKDGVRRHLLDNFNAIPIFLSEDLAQQHYNGFSNSILWPLLHRMPEKAESDENWSNAYQEVNETFADNIVPYVEDNDLIWVHDYHLLLLPGILRERLKKKKGIKIGFFLHTPFPTEDYFTILPFREEICRSLLLCDVIGFHTNQYAKDFLDSARIVLPGVSKSPSDLHWDGRRVLVHGFPLGIEADEWREKLQTDAARKELQALQEEFKDQKVLLGVDRLDYIKGVPQKLLAFDRFLTDNPEWVGKVVLVQLAIPTRAEVDAYRKLREEVERLVGRINGRHGMLPAMLNSSSLERADSRWAPSATFRHNPIHYLYRSVKPEQLAALYAVADACIISSVRDGLNLVSYEYAACQEQKKGVLMVSNYVGAAKILPPSSMVIMNPWDKPRFAEKIKKVLLMSEEEREEKNVSVMKIVNNWTSAKWGKAFLEAMMTGEVPKILGNPDRDPAEEWAFDLSDSQIGNIISEAEADFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG42</accession>
    <name>A0A1C1CG42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_03566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG42"/>
    <dbReference type="STRING" id="86049.A0A1C1CG42"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03566"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01888"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT47494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="389" mass="43434" checksum="10454733AB9A2DB4" modified="2016-11-02" version="1">MSSIRIAIIGGGPAGLALARLLQINNISCTVFELDTEAFGRDQGGTVDLHPHGGQLALKHADLTDEFKKYARPEGEAMKLVKFDGRVVFDENTEGNTRREEYADRPEIDRMKLRQLLVQSLRPGTVVWAKKLQYVEKASTSPAQYNLHFDDSNEEGFDLVVGADGAWSRVRSYLADQQPYYSGFTAIELWATEYDKKHQWLSDFVGAGSCFMFDEGRAIQCQKLGNNSIRVYAGVRQPESWLEDCGIDWSKPDTARQELVKQYYADCGVDLKRALLDANDKLVPRKMWMLPVGYRWNSDTGVTLIGDAAHLMTPYAGVGVNLAMVDSLDLANAIIGCDGDSTKIPVAIKAFEDKMLTRAEHFAQRTYKGLIGHFSADGCEEMLERLKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGF6</accession>
    <name>A0A1C1CGF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_03684</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGF6"/>
    <dbReference type="STRING" id="86049.A0A1C1CGF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03684"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01782"/>
    <dbReference type="eggNOG" id="ENOG502SS3N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5396681at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT47604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="229" mass="25665" checksum="B720B447F678A5E1" modified="2016-11-02" version="1">MEDHLGVTWVDSPRDAREQPVWPVDVDVKWATRELHSLLHRVQGTLEKAAWQSSFASWLLETEDELMADTSLQQKAASVGLRGAVESIASGIDSLHGYLETGAFRLQSQIGLLFNVVGQRDALINFEIGSSAKQDSISMATFTFIAAIFLPPTFVATLFSMGMFDWSDGDGGDGHLSDSFWVFWALAVPLTATTILCWYLWYRHAYRKWQNKFGRRRPDEREGSDAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGG4</accession>
    <name>A0A1C1CGG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">infB</name>
        <name evidence="13" type="ORF">CLCR_03273</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGG4"/>
    <dbReference type="STRING" id="86049.A0A1C1CGG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03273"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01814"/>
    <dbReference type="eggNOG" id="KOG1145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="553"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="101"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="185"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT47572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1112" mass="122399" checksum="EE8C8786F2CCFA01" modified="2016-11-02" version="1">MRRTVTQKLLQGQDICFFCAFRHGIESRVVKSLQPQRRLYRAANPSNRPAGAAVARIEEEEEDFAPPARELLGWKCRCNHVNKPGRSDCTICMSPRPQNAQMVYRDSNPPPPDHFAPPSSNSRLRAGPDGPADPSSISAILSRARSGTQGATWGRPQPDTQTRNSQPQADAESSFRIRNHGVGHPTEKNWRNDRHGGASDSDRSLFRYPDKRTRPAEMRIRGIGAADRVYQEPGPSSRPSRISNDSRARGTDSPVSNESRQQNMPPSRIGAAIGRPDQPMSPRAEFEGAPSESHTWTPMGPATSKRPPQQRVAGREADGRGARDDVRVWRPGMDGSAPQQRSTGQRLGRERRPQPASGSPFQPGNVDEQVGMLDDGPIAGETEDDWHKRKTTGGKERDRRARLYEIEEDGPLQVSRPARSPTARRGSVSRGSSKDFDFDPDLAEEFLDERKRRKKKKGKQAKATRQPARLEIVLPEFISVEKLAQGLKVRLPQFLQKLEEEGFEGARYDHVLDSSTSAMFAELYGFEPVIKAIDQSGDIFPRPPAEDPSVLPPRPPVVTIMGHVDHGKTTILDYFRKANVVASEHGGITQHIGAFSVTMPGSERNITFLDTPGHAAFLEMRRRGAVVTDIVVLVVAADDSVKAQTIEAIKHAREAGVQMIVAINKVDKPGADIEQVKRDLMQHDIVVEDFGGEYQAIPVSGKTGRGMDDLEEAILTLADVADFRAENDGPAEGWIIESRVGITGRVATVLVRRGTLRPGDFIVAGTTWARVRTLRNDAGELIEEAPPGTPVQLDGWRGDDPEAGLEVLQAENEQQAKDAIAVRKERQETAWEMDNMAAINASRAEDAVARAKVLEWEKEQGYLSMGYKRRPKDNEGWVEKGSSGAQLVHFVIKADVAGSTEALVAAVSAIGNNEARANIVHSGTGSLTESDIKMLAATGEVAYAISFNQPIDGEIRQLAAAARIQILDHNIIYKVTDDVTEKVSAELPPIVTQRVLGEAEVGDIFDIKIKKGSMKIAGCRVTNGTIRRSEKIRVLRKGEVIYTGKWSGTSKVACRLADNPLGTLNSFKNIKKDVTEMRKGSECGMGFENWDAFEVGDQIQSFEEHTEKRVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHI0</accession>
    <name>A0A1C1CHI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Para-nitrophenol 4-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pnpA</name>
        <name evidence="6" type="ORF">CLCR_04080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHI0"/>
    <dbReference type="STRING" id="86049.A0A1C1CHI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04080"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08142"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10016252at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050631">
        <property type="entry name" value="PheA/TfdB_FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476">
        <property type="entry name" value="3-(3-HYDROXY-PHENYL)PROPIONATE/3-HYDROXYCINNAMIC ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476:SF3">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT47975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="432" mass="47407" checksum="BB58037164832912" modified="2016-11-02" version="1">MAISLDAEVVVVGAGPVGLLTTLLLAKAGVNVFLVEALPDIDDSPRAMAYGAPAVVELERAGIAAEARKVGMEPSDYDFRLRWITIDNKTIAEFKPEDKIPGSFDAVICGQFQLAKIIQRHLSDYSCAKILFNHRLNDITENEDSITASVDTPTGSKKITARYLVGADGGKSTVRKILDLGYDGFTLPQWLVACNVRYPFREHGFQRGQFIVHPKHFCMVGKIDPTGLYRVSYNEQEDLTREEVLANVHNKFEAIFPGPKPLSKDAYQLEVVSPYRIHQRSARSYRKGRAFLAGDAAHACSPFGGMGLTGGICDAGGLADCLIGVLRKGCDDSLLDKYADIRRQKYQEITNPVSYGNTCALRDTDPETAATSAEPFKTMNTSPEARRMMLESAYLLGHDFRQYWPPSQTISKDEKHAAPPIKAGTAGPNAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIA1</accession>
    <name>A0A1C1CIA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_04327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIA1"/>
    <dbReference type="STRING" id="86049.A0A1C1CIA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04327"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08331"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF274">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="260" mass="28190" checksum="047D9214D8676D3D" modified="2016-11-02" version="1">MARILITGSSDGLGSLTARTLVKKGHSVVLHARNDQRAQAARTACPDAETCVVGDLSDISQTKKLAEDINHLGAFDAVIHNAGLYTGPYRKTKEGWPSIFAVNTLSPFILTCLINPKPKRLVFVSSGLHSGGDASCKDITWQERGERGFRDFQAYSDTKLHDILLACFFAKKWPNVQSNSLDPGWVATKMGGAGATGDIDAAIDTYVMLAEGSGKAKGASGKYWYHCEPRSPKREANEEAVQQKLIRQLEELTGVNVPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIB6</accession>
    <name>A0A1C1CIB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04003"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08410"/>
    <dbReference type="OrthoDB" id="4734538at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="594" mass="65360" checksum="0E384D552BAD8A59" modified="2016-11-02" version="1">MAEEDIPLHAFKEARDSNDKSPSSNLDWKRRNGLLQFIRHNQTIPVALCIGFLFASTAITFTWWLSGEKLQCPKWAIDCSIPPPVEWLRDNIGTVQGLVTFVYATSLAAMAYAAHAWSEASIWPLLAQRPYSIGQMETFLSASRGSVPSTPVAFRHVANFDAALVLICTALITLIPLTAAPLVGYVFHQQIVPLEAKSNYTGGGGTGRHFTQHNPPVSLLAPAVVRYASWAEPLSTEPMQDYRDWFVDGYKLADKGNLAAHAVRLKKTITCRGHQVNNISEGKVSTRMENRTFDDGQGPLPRGSEKVSLLMRPQLTVWADDCQLPSSSRARSTLVFASLNGTIENGIPAYVEHEEIHSLEAVACDIDIDLVDDILCIGDEECREKNSTTQTLTSLRDIYRKSLNEIAVWMAMAPIVVGVSVSGAQPMFYHRPNAPLPHLYTTTIGKGDHWTSEQLEGFINASISAVAQELVVNQPAAHDVQIQSLTTTVKLTSVRVRLLILPVATMLIVMALLVSWSELLHRKYKIPLRRLASLSEFLKSCQTAHIVKEASVDSLQADTPSNLGQLKVMFGRTVGVDANESLIAGLARQVKSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIZ2</accession>
    <name>A0A1C1CIZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04334"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08555"/>
    <dbReference type="OrthoDB" id="4157998at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="168" mass="18484" checksum="EE5AF2465A83CDC1" modified="2016-11-02" version="1">MSSTTDTAKSNNTSLLSRIFRRGSKPPATDAASTTSKDPLVHGQPMKSTSTEEHDLVGELMAKANTMGEDEFKAYLKEHKEEVEEMYRKQGGGIASGDWVSRDWATAVSKNHARQLRASTSSRASHARLDELEGLEDRKALRCLCPSQSRIHRATFALPVSSFRVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ92</accession>
    <name>A0A1C1CJ92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ92"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04388"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="173" mass="18775" checksum="081EB046C5E32873" modified="2016-11-02" version="1">MVLAHSPPQPKQQTREEAAARSNDAGGAQQDYSREAAIKANDRSAPEMCSTPVDRSVVSTNTQHCQERTKPAKKVAFASPVAQIQEITPVRARRSARLKERAHPPSKAAPSASRLTVEYSAPSRAEDRDRPGGQIYRDENANDTAKGPRLGTRLRSTDAKSGRTPTLPARPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJB4</accession>
    <name>A0A1C1CJB4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJB4"/>
    <dbReference type="STRING" id="86049.A0A1C1CJB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03874"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10229"/>
    <dbReference type="eggNOG" id="ENOG502SJ1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5333304at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="817" mass="91222" checksum="1B84F9086FB5462B" modified="2016-11-02" version="1">MSASAVALPNGILPPPAQSVDEALEYEKILRIRDEVFSGTHPRLTVPAHAIRVPSSQNSSALSQNQLHVPSPSPATPSPNRLEAGAQSNKREDELTQPHNKPNGVPAPPGGQPTPSVSEFDPVLLTKSDDLIRAETLLKRQRLEKALRDQFEQKRADARKRPAPAEAKPDFDLPAIFARVTGTAKSPSAKDEEEATDSVNEDEFYSSRAPDSTPEGPPSDSPDEADEEQADESSGLRAVSAVMGAPLYPDADDPISAPVTLPAPAAAEPTKPLPPPDPTAMDVDDEEEEGEYSPPEAAIQVPSPKAPQAEDIRDSRDPRSRPLRRYSEVEDMGPRPPSPSEARMRIVRNHITSPVAPRPSRVSPLAVTKDSPLSQNARSGRKQWIGRPGSPPSPDDNQTLPARKRRKLEGRNQKRQARRNGRMSPDVKEEDISPPPFHDVQPLGTARLHPGGADRPIILDDESAQEVRYAVPPHERYVESPARPLPRQVERLMPSSEPRPLSRSSMRPGRDDQDLRRVASMHTLRAEQPRDYVDPYYDTPTRTRAASYARTGSPAITESGRPLRELPVEYDHPRPPVYRDVYDERDGTYHRYVAEPLPPPVERIIVDQYGRRFREIVHERQSVAPREVPIRREVEPVYEQYPRQGRAGSVFVDSPQERAYGADMPPPPVSYRRVADPPRASAVASPVTREYLEPAPPMRSASVQMMERPVRQTMYPDERAEFREPVRAGSVRPPPATRYEEGPPMEMIPRGLSVRPVGREGSVFMDDRRPLAPEYAPMSDPRYRPMEPERRYIDVDGREIIQPDGAMDSRLRVMDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKE9</accession>
    <name>A0A1C1CKE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">cta3</name>
        <name evidence="25" type="ORF">CLCR_04524</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Noorani M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKE9"/>
    <dbReference type="STRING" id="86049.A0A1C1CKE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04524"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02921"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000020">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="820"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="853"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="894"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="943"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="995"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1030"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="15"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="405"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1104"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OCT48990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1133" mass="123925" checksum="3F5B286814253A97" modified="2016-11-02" version="1">MGKKSARAEQSYSKHPFLLTPDEILSHLETNIDSGLSSAQVQRYQEKYGPNRLEGDGGVSWYSILGKQISNAMILVLVLAMALSYGVEDFVEGAVITAVIVLNVLIGFYQEFQAEKKMDALRSLSSPSAAVMRDGNEMTIPSAEVVPGDIVSIKTGDTVPADLRMFEVMNLECDEAILTGEALPVAKEVEFEAKHGTTKEDLGLGDRLNIAYSSSTVTKGRGRGIVVFTGMSTAIGGIAASMQGKRRPANRSMSRKKYGRMQPVKGGALRTYDGVRKFLGLTGGTPLQIKLSKLAYILFGCALILAIIVFGVNRFNVTNEVAIYAISTGIAIIPESLIAVLTITMVVGMTQMRKRKVVVRQLSALEALGGVTNICSDKTGTLTQGKMVTRKAWIPGVGIYSIENSSNASDPTEGTVILGKAPKSRQEHEAERLAREEALDRKRSTAGISFDVPNEKMHKDAEKSSEETLTEGKESPEVTAELQAFLESAALCNLATVRKVTEDGQEKWKTTGDPTEIALQVFSHRFQYGKRTLEDEHGWSQKMEYPFDSSIKRMSVVYSKPGEEHLIIFTKGAVERIIDLCTSVGVGGHEETMTPALKESILDQMTFLAEQGLRVLAIARKFTDMEIKEHSDDKIDRSEVEKDLCLLGLAGLYDPPRLETKAAVQACTTAGITVSMLTGDHPSTATAIAKEVGIIPRNMGTLSPEVAAAIVKTATEFDKMSDAEIDALPTLPLVVARCAPETKVRMIEALHRRNKFAAMTGDGVNDSPSLKLADVGIAMGLNGSDVAKSASDIVLTDDNFASIVNAVEEGRRMFDNIQRFVLHLLTSNVGEVILLICGLGFQDRSGFSVFPLSPLQILWINMLTSSFPAFGLGREKASPDVMERPPHDNKRGVFTLELITDMLVYGTIQGTCCLMTFVFIVYGPGPDGLGHDCNHSYNSSCDVVFRARAAVFAELTWLILISAWEFKAMRRSMFRINPHSTSSFPFFRDIWENQFLFWSVVLGAVSVFPAVYIPGLNTSVFKHKGISWEWAPAIVCVFVFVSGMEAWKYVKRAMGWFEKEETEGMKARRREGGALGLRQGFFTMARSFTKSKSEEKRNVMEVGDVSTHGHGHGHGRGPGPAQGSALPRVREEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKF2</accession>
    <name>A0A1C1CKF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKF2"/>
    <dbReference type="STRING" id="86049.A0A1C1CKF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05102"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02928"/>
    <dbReference type="OrthoDB" id="4160690at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650861" evidence="2">
        <location>
            <begin position="19"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="224" mass="21896" checksum="CD729650B1F352F8" modified="2016-11-02" version="1">MRFFPLVIGAVSLASVSASSGPSVFSSLLRRQEPGTPQYDCHANCGNVIVAGRTEGYCDTANFTTSLDACLGCALEFDIWQYYGDSVAEAATACGLDATPAPANATDTATATTNSSGPESTSLTTNSSGPESTSLTTNSSGPESTSLTETASPSSSTEASTPSSSSPATTSSSAEVVTATGGQAGMGGATGSAAPAEETAGSLGNKVALSGGLAALPLVALLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKP7</accession>
    <name>A0A1C1CKP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKP7"/>
    <dbReference type="STRING" id="86049.A0A1C1CKP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04659"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02845"/>
    <dbReference type="eggNOG" id="ENOG502RZ6R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3692311at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="541"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="643" mass="69894" checksum="CDF650321B710E30" modified="2016-11-02" version="1">MARADQEGKPAFLMEARPEDGSLLNLSSDRGTSPSQGPKYTRRARQLSSLSALGESILDLFVAIICAYFIVFAALVYSRRDEPLDRSGNQELLDAAKYNPTIFPILFAGVIGKFLKAVAAIKLENGTSVLSLEYLLQSRTVLSTVTAPLILKTVNLLTPLLFVLWALSPLGGQAGLRAISTKDAYTNTTNNFTYLAYVSPFTNAGVNSASAEPLVPINAIFTSALIGSAKAKSLAQDQYGNVKVPLYESLPSATSDSARGWRSVPDNGDYQWSSLTGLPIHGLPSAGVSTFNLETGYMVTTCNVSGHDWSDGYRQSLMNQSLWSGANYAFTMGTGSPFTQYNFSFLSLDLLDSGSTVPTDKILTIANCTVTMRYVEVQIKCNGQTCESVAVRPSNNPANHTEGPGVTSLDEAHYTPINGLGQQGTMYMSFLADLTNATNPTVGCDTTFCPPSVVEAYLADPANTVLQTATTKLWKLGDELISQRFTQLFNTYWIDSIAPAPVSGNFSLEFSELGTTQQYNTDSTLGTITTSQRVIKCDYKWLAILLVCSLVLFVIGLATVVLTALRRGPDVLDRFSPLLRYSRFANIPHKSSMEDATEQSRRLRNLTVRLGDIRPEDDVGYIAIAVLDGTHPVQKLSKRRTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL19</accession>
    <name>A0A1C1CL19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_04804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL19"/>
    <dbReference type="STRING" id="86049.A0A1C1CL19"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04804"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02753"/>
    <dbReference type="eggNOG" id="KOG2183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF38">
        <property type="entry name" value="LYSOSOMAL PRO-X CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650882" description="Peptidase S28" evidence="6">
        <location>
            <begin position="26"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT49179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="54359" checksum="C99AF993D484C89D" modified="2016-11-02" version="1">MKSLFRPLVAAAAASIMATTPGAAAASSSNCSTQFFTQAVDHGNASAGTFQQQYQVVSHSFKPGGPILFYQQPETKAFACMELSIFPEWAAELGALVITLEHRFFGLSNPSNASDPGEKYKTLTLENVMLDAVTFVNHVKNTTSGAKDSKVIVTGGSYGGFLATVFKTNYPNVFYGSIPFAAPLRSIGANFQNPQRYNWFKWANQIYQDLSASAAHKMQFALDTLNQRFQTGESHKDCESVYKGPNEVLTVSMPATNMTAIAQDLNLCSIPHTDDDLATIMALINVVAYSIPLTSYKSPVANPVGASPQKLVNETLLLNDSTDIVNAILTNYYPPSLYPCIEWNSTESANPTLQKDSFNYLLCKYFPLSSNEIPNGTIFVPTSIQTESDPTTCKKLYGLVPPTQEYVEKKYHITHDELVNARRILFAYNEMDPTTAVGIDPLPLTQDRNASRYMFTSLAAHGEEMLASYPGDKPSVMHARQVQLQTIKEWLGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLK7</accession>
    <name>A0A1C1CLK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05295"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="87" mass="9625" checksum="B79B6ED58302FAB2" modified="2016-11-02" version="1">MHMKGVEKFGLINHKVRMSLGNNAVLDTNYIEAETPSREVVKLDTCGRAPASGLQDIVEEEIRIRAQRQHLGASGTNFHGGPDKNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLW3</accession>
    <name>A0A1C1CLW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative sterigmatocystin biosynthesis P450 monooxygenase STCB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">stcB</name>
        <name evidence="9" type="ORF">CLCR_04781</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLW3"/>
    <dbReference type="STRING" id="86049.A0A1C1CLW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04781"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01754"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF96">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE STCB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT49469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="461" mass="51556" checksum="ACBDF0B4746D0E72" modified="2016-11-02" version="1">MQQLSVLALQHGRVSIVVALAVGVLLFYAIQTLKGKRSFWIDQLHQQYGPYVRISPSEVDVSDAPSFYDIHKIGSAFLKSPWYTKFRGEVNCFTASDPHVHSRKRKILARPFSKTSLRDSWEAVVSGFSQRVVAQIKREAEQGSADVFLWWTYFATDVIGELSFSESFGMVESGKKSQFIIDMENITYLSTLRSEYPFLYNSMVKLSFGYLDPLGHARESIDRITADIIVKARERSLTKKNIFAGVLEETESETPMSEREALIEATMLVVAGSGTTAVTLTYLVWAVMSNPSIQARLEEEVATLDSGFTDAQLEALPFLNAVIQETLRLYGAAPFGTPRTVPKGGYTVGGQYHIPEGQTIITQAYTFHRDPSMYNHPYEFIPDRFIDAKLDKNIVFAPFGAGSRTCLGIHLALMELRHAAATFFRECAGAKLHPSTTPESMKIEQFALISPKAKRCLITLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMA2</accession>
    <name>A0A1C1CMA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07543"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09921"/>
    <dbReference type="OrthoDB" id="10507458at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="210" mass="22577" checksum="E631923B727C307B" modified="2016-11-02" version="1">MGKPEQRQEETGPMGSASLQTRDQRSSAPARAGRGTDERGEQFTSIGALEDACNPPPFRIPRAVLRPLPAAIRSGNSRPVSRASGGEEALRKMGTDNLGNAEGSPSIDDNNTARASSSANVLPPELEGNDDEPTLFAEPWFVQDGARSSRQGTKPNAQPESTEDTTQAKKRSAQPDSIEDNRQAKKQELEAAEILLGMKYSAPTKYAQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMG8</accession>
    <name>A0A1C1CMG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative C2H2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_06688</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMG8"/>
    <dbReference type="STRING" id="86049.A0A1C1CMG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06688"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09943"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF25">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="264"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT49697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="772" mass="86409" checksum="D6EB24DCAD9EC2C5" modified="2016-11-02" version="1">MYESLHSQDAGQRNEFNNADLDLGSSRGNDVDELWTDARAVTRLALTATSIEEPTYPNESLTGRSEEQRLADDIFEDVAASSRLHADVGADMARTVIDGSFPELDSGISSVIPSQVGSFAPDFADDFSAFMDAVPNLSYTFSPTYQPLPVFFNDPDPSLQATVMAGNASVGVEQHDGPRLERPSSSLQTDSMFSRYGSRLPSLQPEDKPLAVTTNKHRLKLNDRHFLVTADYRQWLINHCVDCCGDSVDPGFTLPSRHALSRYIGSYFKNFHDHYPFFHVPTMRMGEMNAELLLAIAALGARYTREEDAGNDLYTTVRSIAMERLRKHRSTGVAEHRNRRDSTSRNGVNQFDHDSSISETDEGESQVVQLMQTLLLLIAIATWYKREPAAAEALSIRSVLHSLTQEDGAQQKQVPLAGDWRSWTRHETLKRTQLVIFCLFNIHTILFDLPPMMLASELDLDLPCSEGEWRAATEQDWHGLRNASSPEAPHQSFKEALVDLFAGNEDSNKPSQPSGAGFSALAGCALIHAVIQQIWLVRNSRIPSLKHGRRNLTSEEINTFEYALKRWAYHWERNQESSMDPLSPDGPVTFTSTALLRLAYIRLNMDLGPVRSLSSWDPDVVALSLHRSAKADRNEKLTRAALHCAHALSIPVKLGINYVAQTQLIHWSNQHALCSLECALLLAKWLQEVTTTEPSPPLTASENRVLEFVVQLVAETEYKASCQQILQQKNRLSAMTVRLWAKLYQSSSVWETVNLIGRSLQIYAELLEADGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMY1</accession>
    <name>A0A1C1CMY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_06943</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMY1"/>
    <dbReference type="STRING" id="86049.A0A1C1CMY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06943"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08734"/>
    <dbReference type="eggNOG" id="ENOG502S5JC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="10">
        <location>
            <begin position="284"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="344"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="485"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT49811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="572" mass="61396" checksum="6FBAA9680D7358F0" modified="2016-11-02" version="1">MAHSPPATSRPPLPQTQTSFPRDFSAPNGRPSPLGPQSPPMAMNYASSSPQAFSPQQYFQPPAAKRPRLSPDIQSPSATQSFPGTPTGLPSTPASNTPVNGAPAPTARTATLMPPPQRPPDKEDRSHEDILAGTGINIEEESRLLVQNDYFGGSSNSQAAKGSFQYNNNSFPQPGSSGVVGAPTSGQTDGLNPSQEPQPSEEEMKQRLEERADWEASRHSQHPLWDMFLLGGALNERIRNISITEHLVDPQSGVLVNTQKHMPPPTVRVNGLEGASRVIDKGQAILDTQGKGERLSDIMKIINLATQSRITGLLSASSRLAKERRQHSKGKVPDEWQDIAAPPKAMADPLDGAPSPAGSASLKRTHSQAISEPSFSNDPAQVPERLISTFDKVSQTEKSAEEMRRQKRIKRRTVAKDEASATPAADGTPDAASAALEAEKKTTKKERKLAETKFTEQQQHKSANEAARMAVAGILGNRKKAGRTFDWMNAGKAGASPAATPGRPPLSGPTSTAGTPAPERARAAPKDNQFGHWDEDKDARIQARDVLLILESDGRASRSFLRGVSLPEKSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN94</accession>
    <name>A0A1C1CN94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN94"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07654"/>
    <dbReference type="OrthoDB" id="4159683at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="40"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="186" mass="20953" checksum="5988DD0C6E80C614" modified="2016-11-02" version="1">MALAFWNPEISKLQAIYKPATDRVLSWLRSLYGCSMDTKVNYYRTLANNAAREGKEMSDNILNDLQTAIELRIEAANWFRRAGTAHVEECSKHEHMISVLQAILSAFYPSLPMVPTPGPSTGPTPPTAPSPSPAWRENVPPRPQRWRPPQFQPVQPSSGVVTPVRCASVPRALKLHLIHHHSWRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN98</accession>
    <name>A0A1C1CN98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN98"/>
    <dbReference type="STRING" id="86049.A0A1C1CN98"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07686"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08906"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="170" mass="18383" checksum="0526BBE68B60A549" modified="2016-11-02" version="1">MNTVSIAKFVGVPAALLLGGYHLSLSHNIIPVLYGQPASVAISAFSPLYMTALTQVFLPAGFLSLTSFGTLTYKAENTTERVLYGTAAAMIVGFGVVTKFVIVPVAERLMFFEETTPLESKFGSNDEVVKLLKAFTSHNWFRVIFALGAGLIALYAVMTTVEERAHKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNP4</accession>
    <name>A0A1C1CNP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_06801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNP4"/>
    <dbReference type="STRING" id="86049.A0A1C1CNP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06801"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09034"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="592" mass="66751" checksum="8F184F9364072943" modified="2016-11-02" version="1">MERVQKTRNKGPACTQCRQLKLKCDSAQTFPAPCTRCTRTGSKCLIDSHFRREKRQERIERLEEQLLEAKQKLEGTPREASAPAIGSPEARHRPSVVEEDFSTFDFAQFFEDLQPTTLDGITIQPQTIVELFERYYLYHHSRFPILSSPSITFRSSRKWPPLFWSIILVSAKCRQHVALYSKLSQPLKRLVLSPEYLSSQSLEMIQALLLLCTWAGGDDRSWTDLSWTYSGIATHAALQMGLHRPEYANDFIYGSKFDDEIILSRRKAWIACFIENEMASRRIGVPCTAPIDHTILEALSSPASTIPVKLKQQLQIAYLSYRTNTTLGNSDLSPAGVLQSSISAIHMFEKEFSLMESTSGLLWSPHEEVLFLGSKLNLYIYAITSSNISSTQNGRHSNVDEFIGPALATGLKLIDVANNAEGEISSWSVHTKESLIAATFFLLMLRDSEHPLVDLAATRKAIGQAWNTLHACIITEHDYLSRTCTTISYLSQHPLKREGNGFALKTKSRMASSIMWDTIRRLKEHFGLEKPAQSLSERLAAASGQTQTTPNGTEMQIFPDNLSFDYGGDLIDWDSLFTELGDFYVPPQFDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPL4</accession>
    <name>A0A1C1CPL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07770"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05556"/>
    <dbReference type="eggNOG" id="ENOG502T566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650958" evidence="2">
        <location>
            <begin position="29"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="118" mass="12609" checksum="602D52C3D1890A95" modified="2016-11-02" version="1">MTSFFTSLPTYLLASVVLLGAFSRFTHGEHTPQFYAFQEYHAPDDGSTGAKITPIIDLFVGLSLLFGSKAVRLSAASISLGLCAVGLVVQMKAGKEYNADIALVALAAISVLSQLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQG6</accession>
    <name>A0A1C1CQG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major Facilitator Superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06919</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQG6"/>
    <dbReference type="STRING" id="86049.A0A1C1CQG6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06919"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05299"/>
    <dbReference type="eggNOG" id="KOG2816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF40">
        <property type="entry name" value="TETRACYCLINE-EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="101"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="583" mass="63724" checksum="BE9E48282E15DD2F" modified="2016-11-02" version="1">MLEPEDAFAEEAQEEARLAENSHGATTINTHFHVRDGQEDDTGETSPLMSTRQRRKNPVTYTRARTSYERAINEPWTGAHGAGDLPWHKKPSILWLLPALFPFSVAFGGIIVPKTYLILDLICKQYLSEQALRDPTFKFLPVVLGEENPQCRDPHVQSRVANFNLYVNLLSGVFSAIVSPHLGSLSDRVGRKRVMVCASLGALASEIITIIVGSTDGSVSVYWLLLGGLIDGLCGSFTTALALTFAYASDCSPPERRNVAFGYFHGTLFAGIAIGPVMAGYVIKVTGTVMVVFYIALACQAWFILFVLFAVPESLSKERQLIAREKRRFAKAETAGNSWWTTMKNYNPFEPLWVLRPTGVGSSAALRKNLFVLAAIDTMMFGVAMGTMQIIIIYAEYRFGWTAVNASMYLSAVNICRVMGLLLLLPLLTRIFRGPQNLQSKGHKGSDMLDIWIIRGAILFDLLGYVGYAIGPTGAVMVVSGMIASLGGIGSPTLQSSLTKHIPADRTGQMLGASGLLHALARVVAPTVFNLIYSQTVGIYAGIVFICLASIFVVVFVFSWFLRPNGTFFAPYPSISWSAADDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR08</accession>
    <name>A0A1C1CR08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR08"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09347"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="90" mass="10245" checksum="47672EE829F06D9C" modified="2016-11-02" version="1">MKRSQKSPPHIAKDVDVVCTHQHPEKLTVFQAGEPSAHHEEQLEDMGTEDQVIEYVEKVPQRRRPAPDGTYPKQGEDERVSTEQRSATDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRE3</accession>
    <name>A0A1C1CRE3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytochrome p450 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09293"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09702"/>
    <dbReference type="eggNOG" id="ENOG502SZPH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4161095at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="119" mass="13050" checksum="17650023B20ACC51" modified="2016-11-02" version="1">MSDRQSGSYYASTSYTSSSSSSSYSSSSGTTDPQGHSKSITETMTSNDRDGTNIRRTTEETGKPTLQDETYIPPGGQQLGGREDGGGRRIQDVTDEQAERDREYEERIEDEYAKREGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRJ3</accession>
    <name>A0A1C1CRJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RING finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_08202</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRJ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CRJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08202"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06953"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF42">
        <property type="entry name" value="FINGER PROTEIN (ZIN), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="275"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT51115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="658" mass="73704" checksum="4E1C000621B743C7" modified="2016-11-02" version="1">MWLYSSTSKRSLNSKPSSPRPRSKTSSSTPDLRPTSPSSALAEVLRKNPFRAGSRECLTTQKEDEDPSVALNKDLRVLADFFPDVQVEVLRELLLRFDGDSRLPICIEQLYKYKAGWAKGRMNVPPRGPDEPIAPEEQFRTKDYIDAVKWIAGLEFGALSRNAVDAVLAEVNFSYANARPTLQGLAGKSWKFALANLLKKKRSPSEVPAALLDRSKAGPGWPRLITTGNDELDQELSQLFSLPAQPSRKPVRDQKASDFEVAQALNLKEAEEAGALFECQVCYNDITFEDASVCTRSSHVICLDCVRRTLNEALFGQGWAKSIDVEHGTLKCLADDDCDGHIPHHLVQRSLNLGDPRASGETWNRFEERLAEHNLQRSALSLVRCPFCPYAEAEQTYDTNAAAAIQWHIRKPATGIHTVMVILLLELLPATILFLLPFFLLFPTYFTTLFYTSLANLALKARTTRFVCRNPSCLRKSCLKCQKAWHDPHVCHEPLIVSLRTTVEAARTAAIKRICPRCGTAFVKSSGCNKLTCVCGYSMCYLCRKNIGKAGNNTEGGEGYRHFCEHFRPMPGQRCTECDKCDLYRAEDEDMMVKKAGEEAERLWREKEGMVGVKGLEDAVGNVAGEDTWWKTLQEGRWTVQGIVDWAVENSVVVDVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRP0</accession>
    <name>A0A1C1CRP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08409"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06929"/>
    <dbReference type="eggNOG" id="ENOG502QXXG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4158853at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="536" mass="58017" checksum="FA7294C380FC9EB7" modified="2016-11-02" version="1">MPTTSRSPGSVNSAPSSLQSDTLSAPTVSYRGYKEVPYRAPDNDHVSLSMKHRNHRHEPHDTSSPQMAAIETEARRRKNQPTGCRPRARSLRKSNSSPTVQPRFEQGTVETFGDAPQSKPSRARRWTISSKAASTRGLATLVPAHDTSQRATADSRSSTYENHSPAMITLRRATTARPQRQTTTLTSFPPPKFSRDSNGLLTSFLNTLTSYSDAPVSALGDPGMTKQVAPNSRRPSTSSTKDDARPSTSALAPPVHTEVVALEPRLSISGSNQAASSMRRCSTRYISENVVYEIIWDENLSSSASSEGGNASPGGRGSSLQSREVGGTDTLERRLSNALSRSGRVSTDESRSRRTSYVPGVELSLHSIWTNPKIARLFREPASERLPRSKSSTKTSNVFPSISTEAGSSQVHTTLFPDRVEFFPSYRSQASTNGNGPGGNITFGPAPDDLQGDIQADQNAFSEAQEDVQLGAAGSRFGSMIGVSSHAKRRRTSDHHEQWHRSVNIGGRRASDGRRRAKGSDDETLPLLGGTVDEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS74</accession>
    <name>A0A1C1CS74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS74"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09072"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06734"/>
    <dbReference type="eggNOG" id="ENOG502T5NI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5363290at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18940" checksum="EF4F5733EA99388C" modified="2016-11-02" version="1">MAWRDATVGQSIVMVANGAVRAAQVVTGVLTIFLYAPEKGYWQDHGLPKTLNFEFVLGALAIVTGLALGLVPFKLSYRPVALACPWDLVLFFMYSAAFGIMRNVNSKFLTEPFHHVDQYNDGLFSTHKLAMYDKVWIDLAGMLLFLVSATMGAVLLWTGKRNRTIGRHSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT74</accession>
    <name>A0A1C1CT74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GOS1</name>
        <name evidence="12" type="ORF">CLCR_08998</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GOSR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT74"/>
    <dbReference type="STRING" id="86049.A0A1C1CT74"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08998"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06410"/>
    <dbReference type="eggNOG" id="KOG3208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422156at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT51687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="243" mass="27544" checksum="A17EDA29AEB4157F" modified="2016-11-02" version="1">MTTSTGWAQLRQQIRTLESQVQCPPLLKYSFPGADKCKTETLFHTYSQYASSSKLPPTPSDEEQRNEAEIQELLDKREGLVSQLSRLLDSESALSTSSLKQNNLSRHREVLSEHRQELRRLKASISEARDRQHLLANVRSDIDAFRTNNPAEAEAEYMLQERMRLDQSHSVIDGVLSQAYAINENFGVQRETLSSINRRITGAAAQIPGVNGLIQRIGSKRRRDGLILGSFIAFCFLMLLYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTR0</accession>
    <name>A0A1C1CTR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09362"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="79" mass="8451" checksum="1BC355C1E92E3108" modified="2016-11-02" version="1">MTPIVSTLPTRPINTLFSSSFIVFSTSNPHESKSVSANGQTLISEAHQHAIEMRNRQSQGGSGGHVNGIEISDMDKRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU44</accession>
    <name>A0A1C1CU44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nulp1-pending protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU44"/>
    <dbReference type="STRING" id="86049.A0A1C1CU44"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08003"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06096"/>
    <dbReference type="eggNOG" id="KOG2422">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="893" mass="98437" checksum="C4047D124449002E" modified="2016-11-02" version="1">MSSRALRKLQREQELQRQVETAKKAYEEAEESEEEDDVPEPISAPSRPKNAFDMLDGAEDEEEADEDNETSVVPPEPSAKSETKPTSEPSPPPPAKSRKKKKKQKKKGKTKAEVVEEQKDESGDEVDRALKALAAQSGRKQAALSDTPNTPSWESRATKLLAVDAHNLNPVNEMKSLFGSIALEGQESRSSPRNQRRREQNQQQGGVDLATALTGRYSTASRGKELGALAHRRNVFVQGKEEWPLANSGGLSMELVKADSESMDTNEKRYNIVHNNVYRETQAHFRLAVEMMDPQRMIGLLSMYPYHIATLLQVSEIAKHQGDHAVSGDLVERALFSFGKSVHSTFPAALRNGTARVSFDKPANRELYLAIWRHIKNLEMRGTWRTAYEWAKILLQLNPLTDPYGVTLMIDQLALRGRQHAQLIALCSDDAYGQAWDFLPNIQISLALAYLRSGQPRDARRCLAIAIHKYPYILSALASALDISPLPKTLWAKLPTTDAEKLYTELYVSRAKDLWNTPETISLLGEVAETLPHYGDAISAAPEAPKLEISLEEARHIMLLEIPELIALLPRKFTTMPTSSSDVLPPPDSQSDFVARAPGSGPRGVDATMQTIFNAAGATAGTAGSLLTRIMNWFNTPATANDTLGESEGQAALRGLQEGLGGDIPPEMIEEFLQMQIEDAGGQDLGEGITAAGLGLAEGRDYYLHVDSENSTQDDDQSDSMPELESIPESDTAAAPATQPSHAAMVEDADDDDEEGWQATQRRPLPANRGILRHVDSEDEDDSPNRLAPPAQVSGPSSQRATAPQAPSTNSQVPAAPAQDQELSDPQRLQRWLLTTGLSGLQDRPSDPQALRSYMERLKMLPNRQQDWIVRMVRQRAGEDVEREVRDAMVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU87</accession>
    <name>A0A1C1CU87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">propanoyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SCP2</name>
        <name evidence="11" type="ORF">CLCR_08424</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.176" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU87"/>
    <dbReference type="STRING" id="86049.A0A1C1CU87"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08424"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06076"/>
    <dbReference type="eggNOG" id="KOG1406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000016">
        <property type="entry name" value="Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="10">
        <location>
            <begin position="263"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT52058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="460" mass="49943" checksum="26977CF41829208D" modified="2016-11-02" version="1">MSFQQNAYVLGVGLTQFIKPRQLRPYPELGFEAGTKALLDAHITYDDVQTGVACYCYGDTTSGQRIFYQFGMTNIPIYNTNNACATGSTGLQMARTLVKGGIVDVVMVIGFETMKPGSIKSIWDDRPSPMGLGTRLMEETRGKFDTPRNAQFFANAGREYMEKYGATARDFAEIARISHEHSSRNPYAQFRDVYTLEQIEKSPMIHYPLTKLQCSPTSDGAGAAVIVSQRFLDSRPELKSHAVLMAGQSLMTDSPALFSRSAMDLVGFDMTRRAAKAALAEAGVRPTDVKVCEMHDCFSANELITLEGLGFCAPGTAHHMVRNGDITYGGKGPIINPSGGLISKGHPLGATGLAQCAELTWQLRGWANNGRLVKDVDVALQHNLGLGGAVVITVYKRADGRKNTDASQSDAEIARLSGVGYNPAVEARGVTKDDFEKVRSKVGRSDYALGETAEKIQARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUX4</accession>
    <name>A0A1C1CUX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_08198</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUX4"/>
    <dbReference type="STRING" id="86049.A0A1C1CUX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08198"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05856"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651066" evidence="9">
        <location>
            <begin position="24"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT52311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="549" mass="61137" checksum="D5F61B0A180883BD" modified="2016-11-02" version="1">MDTSGALLFFLAGLIVWAGITRSKRQKDLTAFAARHGCKPPQKHLHNLWWPPLGLDKTLPTIKADRAGRLPAFMLQEFEKHGHTYTQQLPGQYVILTRSPANVEAVCKTRFKEYEIGADRAGNFRPLIGHGILALDGREWVKSRAMLRNTDHDFTQLETHVQHLLGRLTAASQGNEVVEISELLLKLSTDFATMAIFGRSTDSLLFGRQELSAERGEGSAAEFSEAANNAIHMLGQRGLLINLYWIVDSPRFRKSCRIVKRFVDGYLSEAGQSQERVSTRSKAGKEDYTSSVSFMQSLVSRDQASPEVIRDQLLALLLASRDTSASFAAWVLYALARSPRVMAKLRGLIKARVRGGRPPTVADITALAYLRHVLNETLRIFPVVPLDGRTSKTHTWLPEGGGVEGRDPLLVPAGAKVAFNIYAMHHRRDIFGDDADEFRPERWEEDARGARADFEAAFVPFITGPRICLGKNMAMMTVSYVVIRILQTFDTIDPAAAPASTVLGRNPARWPSEETRYQMEDGETTFKIGVTMSPRDGVWVKLQPATLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVC4</accession>
    <name>A0A1C1CVC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVC4"/>
    <dbReference type="STRING" id="86049.A0A1C1CVC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10405"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03853"/>
    <dbReference type="OrthoDB" id="5194044at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="330" mass="36063" checksum="6CB0852FFA7795A3" modified="2016-11-02" version="1">MCFSCGAWPFGQPQVVLAAEPTKEEYIFLDDNHGFYPDHRKTYWPLVQLTLSFCSLHASSGRTMPAHFYTYNSLNPSAVNTQPAAWHWEDPADWPRTYLYVSNQNGAQGIHPPAPVYQSNQPAQPTMYYFQASAQLRDSLTGSASAPAGYYVNGIYHGTSPPAASTGWPYPSSGYTCYTLPTASTPITPSYYPYTYSPYATAAAATSYQVPFAAAPIWSQSPGPAQAAVAVAANAALAAMPNAPAYFVGATAADIQAQNAILLANMQAAQQQPSQLVPFKPGQSPQFWCKELDSSWTLREYSDALKPDFPPGHWEKHATSGYHYYVRHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVM4</accession>
    <name>A0A1C1CVM4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucan 1,3-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVM4"/>
    <dbReference type="STRING" id="86049.A0A1C1CVM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10123"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03892"/>
    <dbReference type="eggNOG" id="ENOG502S6CI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651143" evidence="1">
        <location>
            <begin position="25"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="200"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="493" mass="51514" checksum="40A66EE95DF6CB58" modified="2016-11-02" version="1">MARLSNLTRALALVALGFLSAAAAFTVDPIPGGRDSRPLTGSMSASQSAIRSTFVTMISMSSSYPPPPPRTGPIPLFPIPINATKIGPYPTAPGAPLPLCSGPPTTYTVSHRDTAAKIAAKFNVTTDALEATNAGRVCFWDLLEDGIALIIPPTTCSLYRPPGYSATLTSSPPLASTSIANMYNSSDQSSLHPTTTGPVTAWTVASGDSGSVIASKANVPFFAISSANPSVTWTALSVGQTLVIPPSPTALAQVTGSLAVKSFDSRDGMGSPEVMYTEYDGDGSTAQGWPAMSEWLSFNAQWENIKNYIGKRCGDGVLTNLDTETNDLKISILTVASDTYIDPRFVLATVMQESNGCVRVQTTSDANPNPGLLQSFNGKGTCNHNGTFDTPCPPSVIHRMVIDGVAAPIDGITIVAALNQAAEMAGVEPAQAYYRAARFYNSGPESLPPETNGDLGSNITAATRCYASDIANRLLGWSNGSTGRSPCTLDKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVN3</accession>
    <name>A0A1C1CVN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD linked oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_10455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVN3"/>
    <dbReference type="STRING" id="86049.A0A1C1CVN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10455"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03924"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="FAD linked oxidase N-terminal" evidence="8">
        <location>
            <begin position="66"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT52528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="221" mass="24379" checksum="F82B195B0B903CF4" modified="2016-11-02" version="1">MRDVHIYCEASIWILDGFFWCLVMAISCPWAAELSSFLDDHEIIQPDSRRYNEETKTWAAQRNQSPKLLLRPRSVKQLARVLAYLNGKELDFAVRSGGVGSSSAKDVLISLSAFDGFEHDPAAETITIGAGQTWGEVDEKLEEAAPGYAVVTAFKLKIHKYTNNIYSGNIIIPNEALPELARAVAEFTRRTKDSHASLLSGPRPRGALGSRSPAGHHDRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVN8</accession>
    <name>A0A1C1CVN8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVN8"/>
    <dbReference type="STRING" id="86049.A0A1C1CVN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10986"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03971"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF42">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, ZINC-CONTAINING (AFU_ORTHOLOGUE AFUA_7G04530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="139" mass="15107" checksum="9C76B502048EB347" modified="2016-11-02" version="1">MARTHKSVILAKRPKDNIIPGETFKLVSDNPTPSASDLKDGEVLFETNYLSIDPAMRGWLNDTRSYIPPVKIGEIMRSGAIGTVKASKSSKFPVGSYATATAGWTEYRILKDSELQRLVVPKGGRLTDGLSVLGIQCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVZ4</accession>
    <name>A0A1C1CVZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVZ4"/>
    <dbReference type="STRING" id="86049.A0A1C1CVZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10704"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04014"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057571">
        <property type="entry name" value="SDR_PhqE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23441">
        <property type="entry name" value="SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="262" mass="27714" checksum="4889D51A61795E38" modified="2016-11-02" version="1">MALKYTNKLQGKLVVVVGGTSGIGFGTAEAAVEHGATVVVASSKQAKVSRAVQRIQQAYPDAADRIRGTTVDLSSDNVEEQIDALYDFATEAGKRPLDHVVVTAGEGFGMVPLANVTPQSIVDPYKIRLVGCTMLAKIAMRYLTVSAASSFTLTGGVSDAKPTAGWTVMAPVGAAVRGLTHALANDMKPVRVNCVCPGAVRTEMFDAFTGDRLQEVLDMYTAKTLTAHIGTPEDLAQCYLAVMENKFMTGQEITCDGGYLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW71</accession>
    <name>A0A1C1CW71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RAD14</name>
        <name evidence="13" type="ORF">CLCR_10423</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW71"/>
    <dbReference type="STRING" id="86049.A0A1C1CW71"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10423"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04129"/>
    <dbReference type="eggNOG" id="KOG4017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5368863at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="212"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="311"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT52779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="366" mass="41684" checksum="C4268A4A90A4428B" modified="2016-11-02" version="1">MVGTNMPARPSTPPPQATAKPQSPLTPEQVRRIEINRLKAKALREQREAEVAATAPLRRSDSSAAGQKRSYATYSEAPAATNRDARNEANRPLEAIQPARNFAKYVDYDFSKMADTKGGFLTQEDDPYNKALHADEQDQKPSHLTEKEWERQQLLKSLRNRQAGPFEPGITAMTDQNTKSCRECGTLEVDWKWLDVFNLAVCNTCKDKFPEKYSLLTKTEAKEDYLLTDPELKDENLLPHLERPNPHKSTWHNMFLYLRCQVEEYAFSDKKWGSAEALDAEFQNRETEKKKRKENKFKSKLADLKKRTRVEAYQRSKKGGAPGNFGDDMSGGKHTHEFGQPIDNPETGFPVKTCTICGLEVEELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW87</accession>
    <name>A0A1C1CW87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW87"/>
    <dbReference type="STRING" id="86049.A0A1C1CW87"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09892"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04146"/>
    <dbReference type="eggNOG" id="ENOG502SMKU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="589" mass="66752" checksum="E941CCB663666E40" modified="2016-11-02" version="1">MAMQVAHLRRYGIHILAFVGLTLLLVFLYRGVGISILRDSIPIPFEAASPPQPLPSATRKPCIGPRGRFVQEDRDDQIWAESLDLPFPELVGGSYAALGLPTTFNTPDTRYGAYGYNEEVETYPRTRVEWSSVKWADLQNQCLASNKDRFGRTDRIITDRRFTLRGRINSERLTARTAETGRTAIVLRSWEGYNYTSLDRYHMRSLIVEAGLQSNADIAVFLLVDVKDKDGARRIFHDSKSYDRALEELVPAEFQDIAILFDFELLGSWYPAIGEHSAFFQVYQPLQLFAQLFPGFDHYWQLEMDVKITGHAGEWLDAMARFARNQPRKQSVERSSYYYMPQVHGTYEEFSSAVNQSLNGGGIWGPVQIPDLPHPIGPQPPVADPSMDDFEWGVGEDADLILTNGLADVKATRYWPFKGWVHGFKEGEETPRWYSPVAMGRYSWNLLNAMHHAQVHQGLALSSEASAVSFALYHGLKVVFPPHPWYHHPQADREVGVEELGQLFNGGTPAENAETNHGLAFGRAMYDPNGVYSLFNGGTWWWVPGYPGRSFKQWMNHDTNEMPSMLREFNGQIWAPMMALHPVKVGDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWM2</accession>
    <name>A0A1C1CWM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10261"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04211"/>
    <dbReference type="OrthoDB" id="4135445at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="417" mass="47260" checksum="03C0E923E2E36E94" modified="2016-11-02" version="1">MNLQNGVAHLAQEPQLYRFGNEPWTHGVAHSFEVELAAFDGNEPSEVTKCIRVIQHVQSDQGRLDRFRVHSPRLYHRLLHEEAAQLLPRPETGMTAASLRFVIRLVSGTIDLQGNRQRQSSEFLIWLAQICLTLWRYDCSRQLLVNLEQCAHDFICNDNFEPSENDAAYLAIVAFVLGGRMDDKLYEYVDAVVWRSRADFAAVISPLRRLIIRERQAVLEVIFNRFPQILTSLAYSDDARMKSLGEALHKSFQKFTDLQVDFGKPYAHSHHLNCARYPEILQTKLFAALNAERDSLTDRTPSIASSHSDTSLKPVKQGNGPRLGGGVPALKKLTRTVTGMKPEPPPPAERPAHRLLSIITESKEIIGNRRKRIADAVKDLIEDRDDRCDKGLGRPSTEEGQIEIQVLVPRKDLPHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXB6</accession>
    <name>A0A1C1CXB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">High-affinity hexose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_10557</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10557"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00083"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="320" mass="35255" checksum="42D0E356014E385C" modified="2016-11-02" version="1">MQVLPAVVLAAGVWFLPESPRFLAERGELRSAHAVLSRLHHDPGLVEAEYQRIQDNLEAARDSRMGWLDLFRVPSLRRRVLLACGIQLFTISSGINVINYYGPRIYASLHFSTSRSLMIIGIYGALAQVYNTICIAFVDRVGRRQLLIPSMIGMGAALCVNATLAHYYIDGDQAPGSNGNALRASVAMYFVFSVFFTSVGCISWIFSSEVFPTAARAKGTSLSTFTNWAVNLILAQCSPIALTKLGYRYFYLFTAFNWTAAVVVYFCYPETQGHTLESVNELFGDLRARQEMDSGRSINAAMDVEKVTVPDQAGSAKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXI8</accession>
    <name>A0A1C1CXI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Mitochondrial chaperone BCS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_09837</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXI8"/>
    <dbReference type="STRING" id="86049.A0A1C1CXI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09837"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00140"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="48"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="269"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="339"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="540"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="540"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT53171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="605" mass="68818" checksum="8435085A562758F3" modified="2016-11-02" version="1">MDLQRMRKTAITGGSSLVELPEYIITSFLPGARPLLEQYPFLFRFFGVILALYYFGPIARLKSLWTQFSSMIVATINVSSDEDLFGYLTSWISDHRTLRADQVLNAMSNTPQDTGRRRVRHHDPDVEETKRMNEPPKIKYEQGQGTQLFVHKKRLFFCSRQFGEGHTYFGNRYKRMEIISISCLGRTTQPIKDLIEHIYFLNKARERSLTIIRRPYRGGQTWSRVTSKPRRALDTVILELEQKEKVLADVAEYMDQATMTFYANHGIPYRRGYLFHGPPGVGKTSFALAIASKFNLDVYNLSLLDNDLTDSDLISLLNQLPGRSLLLLEDIDTAGLNRKGKSTTAAARRGGPSWASGLKRGQGPRDADDYNVNDDDEAGTNSRVTLSGLLNAIDGVAAPERHVLIMRTKRTTNKPNELDDALVRAGRISVRVGFKNASKRQAEEIFLRMFIDLPTSASLRGMEEAAGPVTPTEDEKPKDELGLRDHGEETTRLRGLAEAFAALVPEDDFSPADLQDYLLMHKKDPQKAVDEAKGWMEKVYEERKRKSEEQKEQKEAWREEKRKDIDRFREEVKAAVRGLSSEEDEAKQGRERDDKAGDDKKDMTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXR4</accession>
    <name>A0A1C1CXR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-isomer specific 2-hydroxyacid dehydrogenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXR4"/>
    <dbReference type="STRING" id="86049.A0A1C1CXR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10951"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00232"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="1">
        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="128" mass="13883" checksum="A73B83ADAA28B54B" modified="2016-11-02" version="1">MEPWDNDIVSLLPDSHNIYTSVGAGYDWMDILLLTERGILYCNSGPACPLAVADAALNLVISVFRHFTLAQLGAKTGDPQTWSRTRCLTAGGSVESTIGVEQLCIENMNSVFSTRKVVTPVNPEALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY27</accession>
    <name>A0A1C1CY27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_10941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY27"/>
    <dbReference type="STRING" id="86049.A0A1C1CY27"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10941"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00413"/>
    <dbReference type="eggNOG" id="KOG2988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048025">
        <property type="term" value="P:negative regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="108" mass="11530" checksum="322098A8133284CE" modified="2016-11-02" version="1">MAPKKAKKTTDSINSRLALVMKSGKVTLGYKSTLKCLRSGKAKLVIIAGNTPPLRKSELEYYSMLSKTNVHHFAGNNIELGTAAGKLYRCSTMAILDPGDSDILGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYK3</accession>
    <name>A0A1C1CYK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Fbxw7</name>
        <name evidence="13" type="ORF">CLCR_09699</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYK3"/>
    <dbReference type="STRING" id="86049.A0A1C1CYK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09699"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00539"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="12">
        <location>
            <begin position="175"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="361"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="401"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="442"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="482"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="522"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="562"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="230"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="636"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT53582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="682" mass="75719" checksum="D421E66F8FCF9226" modified="2016-11-02" version="1">MDFLDDDNTQMVLDRPLSPRPSRSVTIDPNQLAKSAYSNASTDSIDQETDFPFPTPHDHSPQMDAIRSSKHPRPGVSHTRPKRLSTSNKSGMPLSILPSAPASPPTPAPSPTPYQRAPSWTCAGENEDAFLRDARGHFRDLNAAERERYLAELLNMCDSQLLSFVHNFVSPRLKKDPFEHLPDELCLRVLSYIDDPLSLARASQVSRRWHKLLNDDMLWKIMCDKHAWRRSSSSGPNDDPDLPSLPQAIQGPYARSPKRNLDGSIVGPSSSAPNLTLPKHDALSTSPKAKKRVSQSHYSHFRHKYMIEAAWRKGGESIIKHITPDQGVVTSLHLTEKYIVVAMDNAKIHVFNTVGDHQKTLKGHVMGVWAMVPWDDILVSGGCDRDVRVWDMKTGRSIHVLRGHTSTVRCLKMSDANTAISGSRDTTLRIWDLQSGICKNVLVGHQASVRCLAIHGDVVISGSYDTTARVWSISEGRCLRTLTGHFSQIYAIAFDGRRCATGSLDTSVRIWDPKTGMCTAILQGHTSLVGQLQLRGDTLVTGGSDGSVRVWSLKTNSPIHRLAAHDNSVTSLQFDDNRILSGGSDGRVKVWSVETGQLVRELSQPAEAVWRVAFEEEKAVIMASRSNRTVMEVWSFSPPDEQMDRRSESPLSLPEQPPPIDDDEKPAQFHQEVDVDANMSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYL5</accession>
    <name>A0A1C1CYL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11413"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="273" mass="30091" checksum="B39FAF447728A0D7" modified="2016-11-02" version="1">MTTPTRDAPSHNECREHHSRVHPEAEAFLKPIPLMAARTIPATADPVPAEGQESDLNHHKETGVIPILRPSPPGLHVKSQTIFKVSEVYIVMVSRPATRSQMQTTQHGSGMMEDKSSMMRDSSIALDPVPYQSPPTMTKTRRTRLDSNSNNSSSSTSHIHLMSDATESPNTALLPIAPNSRHFMSVPVAQGIPGSSHLLEIDFFLLCERIVLMVVFLLWGGWRTLLSGSRLGLDLGFPAELLVWITRPRGHTVLGRGIGDELLTCRFGIRVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYM6</accession>
    <name>A0A1C1CYM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_10863</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYM6"/>
    <dbReference type="STRING" id="86049.A0A1C1CYM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10863"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00558"/>
    <dbReference type="OrthoDB" id="434240at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="36"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT53602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="175" mass="19120" checksum="2B735A401A768CE5" modified="2016-11-02" version="1">MAVDIGMPFRAPEVNPITRKARAIPFLNPLNMYGRVFFFSWFGFFIAFWSWYAFPPLLHDTIQKDLKLTKVDVANSNIIALCATLLVRLIAGPCCDHFGPRWTFTGCLVIGAIPTFLAGTAYTKSQLFAVRFFVGILGGSFVPCQVWSTGFFDKNVVGTANAFTAGFGNAGGGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZD5</accession>
    <name>A0A1C1CZD5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11011"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00820"/>
    <dbReference type="OrthoDB" id="4140444at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="13583" checksum="9860E48070184CB9" modified="2016-11-02" version="1">MTTTTPPYSTSHQLARLIGPALLTISMAESVNAHIWASSSPPTIFLNGSIIFVSGLAIVRHHNLWTTSWPVLVTLSGWTGLALGLTRMLIPEKVLESVKKAQPRDVRAGALVVAAFGGALTLCGYFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZI1</accession>
    <name>A0A1C1CZI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10878"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00838"/>
    <dbReference type="eggNOG" id="ENOG502T0PN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4158812at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="185" mass="21644" checksum="9A46546F86DBCCF2" modified="2016-11-02" version="1">MDEDVAFGIFFVIFLLFVFTLPLSLTACIAASATRKWSKEKARQSRSGVSLEESECLVSDSESDCDPEDYLDSEDEEYYNARREHKHREQEEKIADRQLSTSGKFFKEWKRCWRGPAGTKEQLAKERELKETAERRLIARQAVREYLRMERRKERKTRQQQGAKKEQDEALELPTYGNAVAEGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D053</accession>
    <name>A0A1C1D053_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal specific transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D053"/>
    <dbReference type="STRING" id="86049.A0A1C1D053"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00215"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02591"/>
    <dbReference type="eggNOG" id="ENOG502S84A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4590138at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474:SF1">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12315" checksum="D31A9F209BC35450" modified="2016-11-02" version="1">MASTKPQQLENHSTQDSTKEDSVPSNSAPLALPPPSDVSASTSTSQTVKLDALGPMVINSDGTLSRIHNWAEMTEAERERTLRILGKRNQLRRENILAAEGESENGTVADGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0A7</accession>
    <name>A0A1C1D0A7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UDP-N-acetylglucosamine transporter yea4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yea4</name>
        <name evidence="9" type="ORF">CLCR_00182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0A7"/>
    <dbReference type="STRING" id="86049.A0A1C1D0A7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00182"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02553"/>
    <dbReference type="eggNOG" id="KOG1583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="450" mass="47574" checksum="1C184750A8AE6B23" modified="2016-11-02" version="1">MTSQLDSAARKRREPSTHEPQPHANGEFTPNGTVSQSKSKSVPSSPATPEAPSSTTLSILQIWAPTLILIFGGCCSNVYTLESLISASPSSGSLLTASQFLLVSLFTLPRHFSPSCGVRNLFLKERNIPIRKWVIYTAYFLSINILNNTAFRYKIGIPLHIILRSAGPVTTMLAGRFVKGRRYPAQKVVAVVLLFVGVVVAAFSDAAAKQTAVQATTAAVHEDDGIAASTRPSTGAAAAAAGGGAWSQTPGFALLASALVLSACMGLYSDDMYATHGRSGDITAETLFYSHAMSLPWFLGQIRPLTSEFFDLMAVPVPVQSKPSFSPSSAAAAAAAPSSPFSSPSVLLDRLSSTILLPRPVLLLAANAATQLLCIVGVNRLSAQSSSLTVSIVLNIRKLVSLVLSIWLFGNELPWGVLLGATVVFVGGGLYALPARETDKGREKTKKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0B2</accession>
    <name>A0A1C1D0B2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">sar1</name>
        <name evidence="25" type="ORF">CLCR_00195</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated SAR1-GTP binds to membranes first and recruits the SEC23/24 complex. These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated transport vesicles. Conversion to SAR1-GDP triggers coat release and recycles COPII subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 24">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0B2"/>
    <dbReference type="STRING" id="86049.A0A1C1D0B2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00195"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02548"/>
    <dbReference type="eggNOG" id="KOG0077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
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    <keyword evidence="11 24" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 24" id="KW-0653">Protein transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 24" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
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        <ligand>
            <name>Mg(2+)</name>
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        <source>
            <dbReference type="RuleBase" id="RU003926"/>
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        <source>
            <dbReference type="EMBL" id="OCT54146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="189" mass="21433" checksum="64A949A178F42594" modified="2016-11-02" version="1">MWIINWFYDILASLGLLNKHAKLLFLGLDNAGKTTLLHMLKNDRVAILQPTLHPTSEELAIGNNRFTTFDLGGHQQARRLWRNYFPEVSGIVFLVDAKDHERLPEAKAELDALLAMEDLAKIPFLVLGNKIDHPDAVSEDELRHQLGLYQTTGKGKVPLEGIRPIEVFMCSVVMRQGYGEGIRWLAQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1D9</accession>
    <name>A0A1C1D1D9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_00837</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1D9"/>
    <dbReference type="STRING" id="86049.A0A1C1D1D9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00837"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10129"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="531" mass="59129" checksum="2C5BC09E3C68F793" modified="2016-11-02" version="1">MASTDLLATFQKHIEDMRNLSLCKICIKPFYEPFILPCGHTYCYSCLASWFGGGTGRRSKSTCPDCRAHVRVEPSPNYLLRDLVHMFIGRAELLPEDETVQEHQTAKEEEAVLLAADRAGPGLFKGVFVGLGSARGSRNWRSGILDPEDNVWRCPECHWELEDGGCSRCGFHQFDMTGSDSDSDLDESIDLDDSEMDDEAEIDHEFGTTMGEHGFHFHFPATSSRRRSISPGLEDDEDYSDEDDDMDGFIDNEVEDGDSNSDADTESTMTIYNRQLRNHRDNDHPSVSSGVSLDGDIVSHFPYDPAFYPESDARSTVNTAQSTNGDQSDAATNYDEMTEASDIDTTPAQPARRPGARRVVLSSDDEDEDEPGVNPSATADRSAEDRRHYHEDDHDTDNEADFMASVRHRLRRHARNVADSHSDDDDHGDEPNSVSVPLSPQVNEDNTSTTNVLEEGTIWSLAGMHRSIRPGNHIPTVNKVTEDEATRIAINLIRDHLGDEYRLAEEIADCQLSLSDVEPIWAIIDSESGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1F6</accession>
    <name>A0A1C1D1F6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative nicotinic acid plasma membrane transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_00851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1F6"/>
    <dbReference type="STRING" id="86049.A0A1C1D1F6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00851"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10111"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF24">
        <property type="entry name" value="NICOTINIC ACID PLASMA MEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="423" mass="46138" checksum="CB197B88328ABA29" modified="2016-11-02" version="1">MPTSNSGENKVKPMAPSPNDKVGTLNAKGSQAEKALIRKLGLYIVPLIIISYVLTSLDRSNLGNAKIAGMPQDLHSHGNGINCLWHTSEIVAPSLLLMSLGVVSVFYATCDFFEMPITLLVKPLGPCNSKIAKRAAAVCIAVTLSGAFGGLFAWALTQIDGVPGYAGWRWICFVKGTISSCLAGASLFLFPNAPETARFLNPDEKRPARFLAQFRIESQDKDVPFRWSQVVAALKSLICWFSGFIQLCAGVYYHPLSIFLPTILTGLDYGSLETRYLTIPVYLFATVMVFFFAGLADRTQRRAPIMLFFSLFTIAGYAILLSWETPAGVKYFACFLSVGFGNVLLLLNIAWLNGNIGPRYKRATALTFNQTIHNIGSIIGGQIILDRESPRYRTGQAIAISCCGLGCIWSDDSVVAPEVEECT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1K4</accession>
    <name>A0A1C1D1K4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1K4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00967"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="99" mass="11549" checksum="A646DA38FF736793" modified="2016-11-02" version="1">MGVMLYRVPSTVYCSIKPLILDGTIPRTIHLGREATLQPSRRGWTESLAEFLAGEDVLIPMVGYGRICYDGSIRQFETRRDEMRRLDTIRYDRTYYELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D326</accession>
    <name>A0A1C1D326_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D326"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03048"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05179"/>
    <dbReference type="OrthoDB" id="4153491at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT55090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="155" mass="16517" checksum="C3DA3DB979997A19" modified="2016-11-02" version="1">MSMDSKPTTALPTGASHRRSSSGISEDAAQSAHDFMSSTIRRSSSGVTDDAARAAREFMRSSTDSGPGLNDDLADKMHKFMQGPATHRESHSKHLPDVTLPGITDEVAEEALEFVDGVEKTGDPAQGKPRDGTSPFPASWLGSSRGRLRHPLGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C759</accession>
    <name>A0A1C1C759_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Eukaryotic translation initiation factor subunit eIF-4F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_05349</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C759"/>
    <dbReference type="STRING" id="86049.A0A1C1C759"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05349"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06997"/>
    <dbReference type="eggNOG" id="KOG0401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.970.30:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit eIF-4F, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="9">
        <location>
            <begin position="1168"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="499"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="607"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="689"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="990"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1060"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1428"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="689"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="778"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="817"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="993"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1091"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1428"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1530"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1566"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1582"/>
            <end position="1597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT44301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1597" mass="170436" checksum="5528C76DB9ED3011" modified="2016-11-02" version="1">MTSNPQDLSASRPHPSEQQSTATHFATGSNLAAQGRNSFPSASKASSSTPNASEPTNMSAAVGGAPPAHGHSDSVNGRNPTIPAIPTVNGSVSLPDHSRKPSMTVTPAGVTGFTANGGAPGGPQNKPAIQFGAMGMQNPAGSPAMGTPPSLAHQNSANLSVGQLNPRATSPSTSPSPIPQPASVSGGRPPQGFNGQGHAYTFGQTDHNDPSAMSRPLPIQFGPQQDHMRRNSSQSIHSDAGGPGIPPAGPNNHRGGYQGTGRGGRGNFYQQQPTPYSPQQQFRPPPNGRPFQNSYQGGRGQSLPYQGSPAMGTRSPALVNAQPGTPNMGGQVHMVQPGMPQPNGYFMGPQHVKNHPPFPSSRDPTREPTGEPARDKGKPTKGRGRGPARGAGRGKGPGRGGHEDRSTFFSRDPASDHYRPDLAISQPVQVAPELAQAPVQVFQNAPLPYPDLSPESGNFERFQEQVLTVRTQAYPMTQADPSIQQMYMQQMQMYNPQAMQGQFNPPYTMQPQSPRPPFNQGMYGAPSMQPSYSNQGGPPPSMSRQSSQISAPDRPGSSIGQQPSTPAPTGPPHSTNRAPSVSSQKAFTLPPKKSAAIVIKNTAGEVVSFNKPPASPATSTPVSAVVPPQSAPTPPSRTTSAADNAHTRSESVNAKSAEEVKKSMQEAVAKKIAEDEARLKLEKELAEKAEMDKEAAELAEREAAEARAKAEQLEKEAKEAAEKAEAAKQAEAAEKAEAEAAAEEKKRAETESKDNPPKADNQDEIDYDALAAEIEAEEAAREAEELRREEEYNKRKAAQREAERKKAQEEAAAYEQNMKELERKAEEEELAREREKTEGGSGDDDSKKLFAELKRNPFGTPASTESPAGATPAESGTATPVSDVSMPPPGKAAGRRAKAAELTLDTRKPVEPPEPSATLKALQSAKKLDDISKVVYPSDIASPNPALNANAPADRGFKYNKEFLLQFQSVFKEKPTLDWDARIREALGDGDASARPSASARTPSGMGGRSASARGPAPMNFGPMGNFGGMNRPTLPPGTTSEQRFAASNAAMRSGAIASNPFAQFGRPGGQMAPPMGRTPSNNPLGPIPGSPRVGGASRGGSRAESKRNKGNTKGHGEDNKSMPLTAGMNIGALEVSATGWKPRSIGQSMVSGPALGGEGLMDPEMVQRKTKSLLNKMTPEKFDKIADQILEISGQSKHESDGRTLRQVIQLTFEKATDEAHWAGMYAQFCRRMLESMSADIRDEGIKDKNGNVVTGGNLFRKYLLNRCQEEFERGWKVNLPPQPEGQTEEAAMLSDEYYIAMAAKRRGLGLVKFIGELFKLQMLTERIMHECVKKLVDYEGTPDEAEIESLTSLLQTVGKQLDNPESKAQGRMDLYFERINQMIAIPDLPSRLRFMLMDVVDLRSKGWTSKADNKGPKTITEIREEAERQAREDELRRLAAQSGRGGGGGRMPMGRGDARNFSGYGQVPPPDNSNRVGTDDLRRLGNRNARNPSHTSGLGGPPSLMGGRTNSGRRGLGPGGLLGRTDDSATSSRTGTPPAQKEKKDESSTNAFSALAALENDGPASPPSNPASPPTQKSQPRIERERSRSPDKGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C784</accession>
    <name>A0A1C1C784_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative proline-specific permease put4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">put4</name>
        <name evidence="9" type="ORF">CLCR_05667</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C784"/>
    <dbReference type="STRING" id="86049.A0A1C1C784"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05667"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07020"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF39">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="52"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="564" mass="62841" checksum="41D2398067D801E2" modified="2016-11-02" version="1">MDNEKDSKQIRDGEAVIVSEEPLEEGEVYGRRLSATEWAKYRQTKRGLTPRHVQLMAIGGSIGTALFVGIGGSLKNAGPLSLLLGYLCWGLLFIWPAYLLVAEMLAWLPVRGTIFELCGRYVDPALGFAMGWTYFFAGAMLVCTEYSSVATVMTYWNTSVNAAVWVTMALVVCVFFNLVAVRWYGESEFIMASTKILLIIGLILLTFITMVGGNPKHDAYGFRYWKHGMAMHPFYTTGTTGRFLGFFSVVRYAAFTISGPDLISLAAGEIQNPRRTIPRVARLVFYRLVGFYVLGVLCVGIICSSRDARLISAINDGKAGAAASPWVVGIQNLGITGLPSFINALILLSGLSCGNAYLYSTSRTLYSLARDGQAPKFLMKCTKSGIPTYCVLVVTVISLITYLVASNSAVTVFFWFISICTITFILTYVGMLWTYIGWYRALKAQGIDRNSLPYKAPFAPYTAWLAIGVGCVVMLFIGFDCFVPWSTQGFVTSYFGLAYGVFMFVFWKVVKRTKWVDPKTCDIWSGKAEIDEECKEWEDGGFEEVEKARLAQMNIVRRTWERVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8A8</accession>
    <name>A0A1C1C8A8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8A8"/>
    <dbReference type="STRING" id="86049.A0A1C1C8A8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06006"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07380"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="329" mass="36941" checksum="81C05D8889ABB54C" modified="2016-11-02" version="1">MSHKLPNHVFSIPKGREITRTEARLSRLLRTGSLTGTRREKSREQAARMSHQSVGPAQPKDRPKGEAHGTPNGLSTVDGVDGSAAGSVRRGVGAAADGAAGTEHPNADTGAAHFGLFHNEIEDQVRKLQEGWAAVDGAVGNLYFTFGKYGKIVTTVGERYGKEGVLEEKNQKLQAENEVLWERIRGNQDKHEKEISDLCAEHESKLKALTAQAKAGEEEKKRYEDMVKLHEEQNDRARQRIETKLQQRMKQLETEHAAKIAGLESDKKNLLLDKANLTRVLEERTRERDEEKLTRETMQSKLRGDVTKLEEDLADMKARYRVKTQPSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8X9</accession>
    <name>A0A1C1C8X9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-amino-acid oxidase</fullName>
            <ecNumber evidence="8">1.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_05864</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-alpha-amino acid + O2 + H2O = a 2-oxocarboxylate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="EC" id="1.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21817"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.3" evidence="8"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8X9"/>
    <dbReference type="SMR" id="A0A1C1C8X9"/>
    <dbReference type="STRING" id="86049.A0A1C1C8X9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05864"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07658"/>
    <dbReference type="eggNOG" id="KOG3923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000018">
        <property type="entry name" value="D-amino acid oxidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="12">
        <location>
            <begin position="6"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT44985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="363" mass="38788" checksum="E74006399C66D8CA" modified="2016-11-02" version="1">MADKNIVVVGAGVAGLTTAFLLSKNPRYRVTIAAKHMPGDYDIEYASPWAGANYMPVSAKGTPAEAWDRNTWPPFFDLAKNHPEAGVHFQRTEIYNRKKDVSSATAAWFADLVSPNPWFSTLFDDFREMPKTELKEGIDNATCFTSVCINTAIYLPWLLSQCLKNGAIVKRAVFKHIADAAAPGVHHSGGPADLVVNCTGLSASKLGGVEDKSVVPARGQIVVVRNSAPAMYAMSGTDDGPDEACYIMTRAAGGGTILGGCYQKGNWESQPDPNLAIRIMKRCVAICPELTGGKGIEGLDIIRHGVGLRPVREGGTRIEKEKINGVWTVHNYGAGGAGYQSSYGCSQAAVKLVDEALGGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9W0</accession>
    <name>A0A1C1C9W0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Aprataxin-like protein</fullName>
            <ecNumber evidence="4">3.6.1.71</ecNumber>
            <ecNumber evidence="3">3.6.1.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Hit family protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">hnt3</name>
        <name evidence="22" type="ORF">CLCR_06202</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O = a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52140"/>
            <dbReference type="Rhea" id="RHEA-COMP:13186"/>
            <dbReference type="Rhea" id="RHEA-COMP:13187"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:136419"/>
            <dbReference type="ChEBI" id="CHEBI:136420"/>
            <dbReference type="EC" id="3.6.1.72"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end adenosine-5'-diphospho-5'-2'-deoxyribonucleoside-DNA + H2O = a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52128"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:13181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:136413"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O = a 5'-end 5'-phospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13182"/>
            <dbReference type="Rhea" id="RHEA-COMP:13183"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136414"/>
            <dbReference type="ChEBI" id="CHEBI:136415"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.71"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.71" evidence="4"/>
    <dbReference type="EC" id="3.6.1.72" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9W0"/>
    <dbReference type="STRING" id="86049.A0A1C1C9W0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06202"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07955"/>
    <dbReference type="eggNOG" id="KOG0562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120108">
        <property type="term" value="F:DNA-3'-diphospho-5'-guanosine diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000017">
        <property type="entry name" value="Aprataxin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HIT" evidence="20">
        <location>
            <begin position="74"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Aprataxin C2HE/C2H2/C2HC zinc finger" evidence="21">
        <location>
            <begin position="213"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OCT45315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="275" mass="31585" checksum="FC7EBFC84B05D431" modified="2016-11-02" version="1">MTSSRDLDEGQQHDEAFKDQISPTLDRKRNAFSELMSPKPKQAKQIQPQQHNHPRDARNGLLPYILNPTSFSSDIVIQHNENTVLIRDAFPKATVHLLLLPRDSTKWHINPRDAFDDAVFLAMVQKEAAEALQLAASELSRLIGPYSESCKARIAAMESDDPPAELPTGRDFSQEFKVGVHAHPSMNHLHVHIISRDMYSERLKHQKHYNSFNTDFFIPLGDFPLAKGDPRRQTSYQNANLKKDYKCWRCGQGFANKFAALKAHLQEEFRTWRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA22</accession>
    <name>A0A1C1CA22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transport protein particle subunit trs85-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA22"/>
    <dbReference type="STRING" id="86049.A0A1C1CA22"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05521"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08023"/>
    <dbReference type="eggNOG" id="KOG1938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="766" mass="83725" checksum="8F68693F24586CBB" modified="2016-11-02" version="1">MTSSLSDGDPLQSPNNLSSTSIPTLEVPKSRSPARNESPETSTTSLPLRTSSPPALGSRTSTLSGALSRSSSPNGRLSLSFSRFGRSQTHSPLGNPSDTYDDTRSLIVRAFSPTVAIYASPEVDELATRKGVKKGFVGLVRPFGDRINGKVVVRDSAGASRAWEDFGVHFADLGKLATDGASSQTDSDATEKVEELMEHYVGEGFNEAEDVPGRGEASPFYRLFLGRLLCSQSMSAHESFRHPVGAVIAISSATNQPIETLRTLYQQSASGSRALPAYANPEYLRYYVLVHDEDRDDFAKSSALFDQMKRHFGLHCHLLRLRSASCTQSDDDAEALPTSEWLSADEQLALLDDTADLIDLDSSTSPYIFSSDTTALRGFVRELIAQSVIYHMEQRIALWNEQIAARRRGISGRFMSLSKRWTNIGGSSRSSSSASNVGTSGNYDSLQGTYRYDAPESLLRKLADYAFMLRDYKLAASTYEILRGDYSNDKAWKHLAGANEMCCTATLLNPLTSSGSSKFKVENFDAMLQTASYSYLARCNAPHLALRVILLGVELLKVRGRAASELAAKWATRSLELSLVGSIGHVLVSERVASCLADRIGIGNTSWGTRKRKAALWSIMAADEWMKLGRAEIAAGKLDEAQELYGETRHSESHKQFHDLAEYLEQLRLAVRMKLGEARKRGFSGATRRLELEGPVESPVDVEDETVEEMNSLERTDSRGRRRSSLLGGGGGSTGAGGVSLIEPLTPLSPARLGRPDKFLQDDDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAV3</accession>
    <name>A0A1C1CAV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_01753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01753"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="102" mass="11133" checksum="07DE9C130918E114" modified="2016-11-02" version="1">MWQYEYNRRYRVGPQPTDVAIVSPVRSPDPNLSLVEKTGEPELDSSTRELFLVEGFAHRSPEALDLVAGGSSRAPAKDKVDHRDIGAICVEGTLVALLEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB13</accession>
    <name>A0A1C1CB13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ser/Thr protein phosphatase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_01603</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB13"/>
    <dbReference type="STRING" id="86049.A0A1C1CB13"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01603"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03566"/>
    <dbReference type="eggNOG" id="KOG0371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF4">
        <property type="entry name" value="ZINC-DEPENDENT ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="107"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="393" mass="43073" checksum="4419E6E5420BAA51" modified="2016-11-02" version="1">MPKSDLPVFDSDATQLPGTVMKFKRVSPVLIVLAICSVLLWIKVILPFIEEGRSAWSALNSESAAGGVFGVNKHPGLPGSIHVKTLDPDLLPRSTKGKTGPEAVKKRLVFIGDIHGCREELEALLKKLRFDPSKDHLVALGDIVSKGPDSLGVIDLLRRYNGSCVRGNHDDRLLLVAQSFQAQSSATHKSLEPGKHTGKHKHEDPVERLARSLSTAQLEYLQTCPIILRIGEMEAFNGEAVAVHAGLVPGLALDLQDPVSAMNMRVLDLATHLPSHKHKLKGSVAWYKLWNRYQQLLNLHKRFGKHKEERESESHTTVIYGHNAKEGLQIRKYTKGLDTGCVKGGKLTALVVDGDGRQQIVQVKAKKHTHRSSLQVDVLRDGGPEAPPSDNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB70</accession>
    <name>A0A1C1CB70_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_01616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB70"/>
    <dbReference type="STRING" id="86049.A0A1C1CB70"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01616"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT45726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="318" mass="34790" checksum="9F5AB18361FDCB15" modified="2016-11-02" version="1">MLWRSDALAQRCSGGALGSYSSAQVTRGVLGALSQVISRPALETLHFPTVIVLRSAYGQRDVVRATSTMLLQHQQPPVHVGQFTLVGKFSCRGVLVLCCPEYNDVGRRRSTGGKRVAVAKLTRCSRLKHVCNYATDGDGRKANNASIATASVKERNFSCADSSNSFARATGATLQHATASSGTKWQMPNPCPPSSVRTPYLGIPRSLIITLVDVYYANVYNASLLLHKRMFLAAIAAGTACQHVVLSVCAFALNFHQDDNERSILRDHSFNTEWADQAGKLAFQDIENPTEDHVVTFMNLALFWYSQGAWRRSAIHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBM7</accession>
    <name>A0A1C1CBM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000018">
        <property type="protein sequence ID" value="OCT45872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBM7"/>
    <dbReference type="STRING" id="86049.A0A1C1CBM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00065"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="163" mass="17977" checksum="F95231D6EEBEBA00" modified="2016-11-02" version="1">MGFEHLAEEAGHGFEHIVSGIHDVVDAAKNMFNPDGDDCEHGEEGNYDGSEDYDGEDDGSGDNHHHHHHHKDGHEGHDGDEHDGSWDESGHGDDDHDHSHSRSGEDSTHTKSRVAEHDDHDWDHHGGHDGHDCMDEHGKHGDHGGHGDHGEHGGHGEHEEECY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBQ3</accession>
    <name>A0A1C1CBQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein EFR3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">EFR3</name>
        <name evidence="3" type="ORF">CLCR_00031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000018">
        <property type="protein sequence ID" value="OCT45897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBQ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CBQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00031"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00050"/>
    <dbReference type="eggNOG" id="KOG1877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="895"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="895"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="945"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="960"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1057"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1126"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1194" mass="130261" checksum="92A966A2DE7E18E8" modified="2016-11-02" version="1">MSSLLNPIHSAKQKCRPKHQVLVLKCYPKYQKTVQEVKPMSSELSYLLYYASTRRNKLQKVGAFLEKKTAGDVWKRRLGNVQVTLQILTAIIEKAPRDLSLYAKSVLTILDSVLRSDDVNMVEDSIPTFEAYCKYVTSASLTADQQRAQQYLSIVQHYAGFAAKKNLANKKTGDSIPLSLRWRTIGLRAIRAVVASDALATDSNHQLNMVMPVILENMSLEEENILSTLQQRAKTSERMDDESARRRRVSIATVTTVDTMEGDPAAAVETTAGADKVAEEEVRTVALRCLKQIFSVGTGSTRGQTRLATALTLKFIASKNPPKVTPEASHMGNWATSLFEAIARWTPVQDRFIIVVTAMETLVRSPMVEGVLEKQLVLTTMIDWLLSSPVNLIGLSVMDILLGFIQHMLVLLQLGGPNARFGQTHRQDTLGFYKEAKEAFDPSSVLVENNMARTPSKELVASPVRQELLERLQKCIASLSNHIYYTDQISDMLTAILARLKPSPQSEVPTTAAAINDPAAATKAIAESISIQEDANSSTFFSFATARVTACRVIKDILVRANSKRNATGAPIEARARVGLQVWEGTQWLLKDEDRDVRFAYIDALLTWLKLETNKSDMLLPKDGHPKKPQSKKPQGDNVAAKRAVSNASRKETKPARSNFLALLHLAVYDSILDEAEDETNILLLYLLLTKLVERLGVNAVRSSLPMILRLQETALNGEVVAPAGRVNVGSVVHGYLWTIADKFDFETSPIGHEINAEISRRKRFGIWFDKIKFPAVPVEEIKLISARDEKRPVYNEEAVETIKPFLSVGGIVEEIANAYDQSLLTPPTSAPSSPGRVFSVPTLGFGYGYGAAPSPKASREDQLPQKVKDEMTAGWSREACIAAVEKESAVSVSGSRTGASSIPNHHLGVNGSTRPHGSVSGKESPALANGSMNPAYGLMGGLGSLTQMRRPSANGSPARVPTTSSRDSTVRVTDLKRALSGYAVAGRRHSPVRGPQAGSRRSTGSSGTSSMLSWDDADDRNPSFVNVGGDTEQATKDSPPTRPKTSESTKSKADRTTTSTYHDQTTLPVSADPTSDTNVPPVPKIPSTLNLPGTWPRDASREASPVRPTDQKPSPVPETPKSRKVTSSAYSPASTREKQSIRKSSRPISRKGVAPLSSSPSEKFDLGSLLAAIPTTGDLEKEGRASRLIRPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBX3</accession>
    <name>A0A1C1CBX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCNGP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBX3"/>
    <dbReference type="STRING" id="86049.A0A1C1CBX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00512"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10372"/>
    <dbReference type="eggNOG" id="KOG2959">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1714508at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012479">
        <property type="entry name" value="SAP30BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464:SF0">
        <property type="entry name" value="SAP30-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07818">
        <property type="entry name" value="HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="26655" checksum="10EC992F1A2B5ADB" modified="2016-11-02" version="1">MSSLGLVGYGSSDSEDEPTTKGAGPSAASSNNAAQDRKLAANGTTKTREVDAARNGDEGAGKDIDEDGPMVGPTMPKHFNDHEQEQPFEPEHRMSERETIHDLTQTTHPMTSMPPSPPGSPDPALNAKFIRFLELKAKGVHFNEDLANKSTFRNPGILASMITRAGLEDSDQYKTSLPLEVFNPGGFPAAAYKGELLRSQQDLREQEKAAKKTLSAAGKRTIEFASAGTSASSSRESTAETPNKRKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBZ2</accession>
    <name>A0A1C1CBZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBZ2"/>
    <dbReference type="STRING" id="86049.A0A1C1CBZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00521"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10024"/>
    <dbReference type="eggNOG" id="ENOG502SEWH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4085451at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054448">
        <property type="entry name" value="HTH_put_ascomycetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22943">
        <property type="entry name" value="HTH_68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="2">
        <location>
            <begin position="151"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="196" mass="21142" checksum="A59403AD0C727247" modified="2016-11-02" version="1">MGNSSSKVARATGSAARRKYPSTPTMLNSGTVPSPEDAPIKPTPAASVRPNVNAAPPSDQKAEHVELDARDPQFGSALRQVGAARPITERKPNEEYFPTSSQPMHSGPNIFPSQPNNPAVLLVQARQRILRQWESELEDQGRPSFAGRTLMSAQEIRQALTSRDDAGKSPSDVEKQMRLKPGLLDQLVAKGVVGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC95</accession>
    <name>A0A1C1CC95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase nit2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nit2</name>
        <name evidence="3" type="ORF">CLCR_00492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC95"/>
    <dbReference type="STRING" id="86049.A0A1C1CC95"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00492"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10325"/>
    <dbReference type="eggNOG" id="KOG0807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110050">
        <property type="term" value="F:deaminated glutathione amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="272" mass="30180" checksum="F45F48F07B21A0D1" modified="2016-11-02" version="1">MSHNLAQCQKLVQKAVAAGAKALFLPEASDYIASSPAESVELCQDVSRSPFVRGLQKAAQENSLPINVGIHEPTDPPSKRIRNTLIWIDHKGNIAHRYQKLHLFALDLRPSGPRLKESDSTEPGNAIVPPHPTALGRVGSLICFDLRFPEPALRLRRLGADVLLYPSAFTVPTGKLHWEILLRSRAIETQCWVIASAQCGKHNGKRVSYGDTIVITPNGQIAGRLDHVKNVEDEKEQAREPDILTVDIDLEAIKQVRHSIPLQRRTDVYPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCG2</accession>
    <name>A0A1C1CCG2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dsba oxidoreductase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCG2"/>
    <dbReference type="STRING" id="86049.A0A1C1CCG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01185"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09307"/>
    <dbReference type="eggNOG" id="ENOG502SHVE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF52">
        <property type="entry name" value="DSBA-LIKE THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="88"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="270" mass="30361" checksum="46139A4365F67B00" modified="2016-11-02" version="1">MDERPVRLKSAITEDNSVASSDWAQGDSADLSLPSFLSSARFENSAAVVFCITDCCSLAAGSLQKASRPDHDVRSTNILHLGYNLSLALRRFRESDEAKDVTFTVKYFPYQLYPEATKEGESKYEWYKKSRYGDSEEKMKMFGGTVASTMDAHRVIQHFQEEKGPEVADRIINSLYSQYFENEKHPSADETLLKATTDAGIPESEARPFIEDKTDGLLDVKNMVRQQAGNGVDAVPTIMFEGKRRDITLVGAKEVEEYEKTLKQIVKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCR7</accession>
    <name>A0A1C1CCR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">cdc17</name>
        <name evidence="16" type="ORF">CLCR_01075</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCR7"/>
    <dbReference type="STRING" id="86049.A0A1C1CCR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01075"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09255"/>
    <dbReference type="eggNOG" id="KOG0967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:cell division"/>
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        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
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        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA_ligase_ATP-dep"/>
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    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 12 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="15">
        <location>
            <begin position="593"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="847"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT46266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="867" mass="96290" checksum="17E5AB9B0F0E9D8A" modified="2016-11-02" version="1">MPQARQSTLGKFLGSKQDGTKPKAQSTLSFNQNALNAKRTESTVVNGSGEKEEDVTPDTEMKDACAVRNGEKDTEDSSGKKNKRRSVESEEAEGEDDDEDVQPPVKRRRRTPTPKAGSKKSAQASSISSKNKADSPQEKQPPATTKVNKEDVDSPDGKLPVSETEEEASVSEGETPKVDKKQVAKIQATIASTGKDPYPDWKAGEAVPYAALCTTFSLIELTTKRLQITAYCSAFLQQVLRLTPQDLLPTVQLMLNKLAADYAGIELGIGESLIMKAIGESSGRSLSVIKEDHKKIGDLGLVAAKSRSKQSQMFKPKPLTVRGVHQGLLDIAKMEGHGSQDQKVRAINKLMASADVSSASKNVDIEKDKGGPSEAKFLVRFLEGKLRLGLAEKTVIIALAQAVVTHEAAQKGKVPSTEKLAEGEAALKTVYSELPSYEVIIPAMLEHGIFNLHETCKLQPGVPLKPMLAKPTKSITEVLDRFEGKDFTCEYKYDGERAQIHYVAPEATSEFPAAENTLSKDPKAFKGLAAIFSRNSEDLSKKYPDILERLNAWIKPSTKSFVLDCETVAWDPQNKRVLPFQQLMTRKRKDVKTSDVTVKVCVFAFDMLFYNGEALVKKTLRERRELLHSAFQPVEGEFQFAQYGDAKDVEEIQHLLDDSVKASCEGLMVKMLDTEESGYEPSKRSRNWLKVKKDYLSGVGDSLDLVVLGAYHGKGKRTSWYGAFLLAAYNSDTQTFETVCNIGTGFSEQVLEELHKELSEIVIDRPKPFYSHSTTKNDQPDVWFEARYVWEVKTADLTLSPRYRAAIEEMGGKNGISLRFPRFIQRRDDKKTDEATTTKQVAEMYRKQEVLQKEQSGKTGVDDDFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD23</accession>
    <name>A0A1C1CD23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative aspartic-type endopeptidase opsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">opsB</name>
        <name evidence="14" type="ORF">CLCR_01167</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD23"/>
    <dbReference type="STRING" id="86049.A0A1C1CD23"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01167"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09173"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF12">
        <property type="entry name" value="ASPARTIC PROTEINASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase A1" evidence="13">
        <location>
            <begin position="59"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="464"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT46356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="508" mass="51864" checksum="431325C941004A11" modified="2016-11-02" version="1">MIFFAGASIVALVGSCIASPGYLKLDLHKRAPLATRLVRRQGSGGSFVAVLTPNREIEYLVNITVGTPPQALAVTLDTGSSDLWIPAASAPLCKKGQCDFGSFDPSSSSTYQLVEQAGFNITYAAPGDTDAGDWGSDTITINGSSPINNQQIGVASVLVDQHGVMGVGYDTNEAKNDGPNGVYQSVMDNLVKSGIIHRKAFSLYLNGLGASTGSIILGGIDTTKYSGDLVALPLQPSQDGLVKEYYVTLTGVSFTDATGETTELSPQGYSQATLLDSGTTNTFLTNDIFTPLALGFGAVLDAEGTGAYLIPCGLSGGNGTISYSFGGEGGITISVPLANIVGGQIYTPENFDDPSGGCMLAMETTRESSGFSILGDSFLRSAYAVFDLENQVAALGQADENKASTSNIVVIPTGTAVPRATATATATGTQLTAITAETQVPEASFSRSSLVLAGTPTFNLGISSSTRTAGSGPSSFGYSGAGSSHGCPDSGSTGTGSGSRSHRALATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDG9</accession>
    <name>A0A1C1CDG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01831"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01226"/>
    <dbReference type="eggNOG" id="ENOG502ST9Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5244622at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="758" mass="84236" checksum="1D7516DE29855246" modified="2016-11-02" version="1">MTSKMSDRLFKYPPMERQDLNQSQLGSFKFTPVDPVDLKSLTQSANQFLEQQFFQRQRLSVASASSTGAFQDSASTLSSDRGPHQPNQYAIDTEFFNKHIKPDLGDSRLRLGPAALRSAVDGASPAKEQSLIHVQPEPDFSVKYHRPSNSINVTSPQYPAAIMDPTAAAFMPTADALSPGVSDPVWISETLCNALANEQRTHNITKATLAQHVTRCIELEDQLRRSKQQIASMTVTIKSLGAIIKHNTSKQNSEQDGSHTTLGYSEEAEEVALRDFYREYNRLREAAHKGEEETGKGKEFDNNDSRQENDTTKQEAVEVVDDAQLYNLDLLVKPDTGDSAESVLRRTLRKHFSLDSSADDGKAPETPQNTRDTLTRLVDISPESGAGGKDAMRAKGHVPVTNGNRSLTRTQIRPSSSEVVAKSGYQNVSLSLKEKCNGADLEMEHIGNLDALGRSEDAVKPPQDVKDGRLSPISSANDEDGRSTTAVVSPTDQPRKERITLKIGSNLYGETKWLINKDYPIFETEEEKFEAVSGNGAAFHRNSPFLNHPVRHLPEDAASTIDAYRTVMIDEIPAGSTMLDVLSIVKGGSVESIQLFPPIGNATSFMTARVVFVFERSAHNMIKHQEAKSKEDAGTRRFKIKDVAVRCWMPTDPTYPRNYEVDHEIFGDNQATRIIFVDQVDEYVYSALPYKIRSPYDQHVIEYSYTAEGCASIEFSDIKSAIKVKAILEKDRGMWPAQLRYAEDYTCVPYVHGEPMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDI4</accession>
    <name>A0A1C1CDI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_01941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDI4"/>
    <dbReference type="STRING" id="86049.A0A1C1CDI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01941"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01247"/>
    <dbReference type="eggNOG" id="KOG4127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="508" mass="56102" checksum="DE65E11D3EE68A5E" modified="2016-11-02" version="1">MSPTEIDPLLPQNEPAPEIQGHGFSRYRGYEGIQPSPGYEEQPKQWEDVHQPQPGYQDEGEEDDDTQSVSMESTQSALKRIIGFFSIVVLMGFVVALLSPRTADQEPIPVPKRPQSIEERVSAILNHTPLIDGHVDLAIFIRGRYENKLHTKEFKEKFENGNMEANVDLPRLRKGMVGGAFWSAFVVCPEHASEDFSDEQYATAVAHTLSQIDVLRRLQAGYAGNFTFATTPLSWQLAKFHASRSLISPISIEGLHQLPQSAPLSTLRLYHALGVRAATLTWNCHNAFADAALISTRNGTHVAPYHRGGLTSAGREVIREMNRLGILVDISHTSYWTQKAVLSNNTSAAPVIYSHSSAFALCPHPRNVHDDILDLVKQTGSVVMINFSPGFISCLPPPDESVLPEFYEKNNTLHQVARHVVYVGEKIGYDFVGLGSDFDGMGELTPRGLEGVDKYPDLIAELLRMGVSDADAAKVAGGNLIRVWEKAEVVARKLQQETLEGEDAVSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDM9</accession>
    <name>A0A1C1CDM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_01853</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDM9"/>
    <dbReference type="STRING" id="86049.A0A1C1CDM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01853"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01300"/>
    <dbReference type="eggNOG" id="KOG2423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000200">
        <property type="term" value="P:regulation of ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="221"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="522"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="543"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT46571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="590" mass="65509" checksum="96A9FA4230E31718" modified="2016-11-02" version="1">MGARKKEAARRERQGVSTDGMANVKVKGENFYRNAKKLKTLNMLKDGKAQRNAEGKITKAASYQSRELPKARVEPNRKWFGNTRVISQDALDSFRQAVAERAADPYQVLLKTNKLPMSLIRDAEHTKNGIKQHQAKIAVESAPFADTFGPKSQRKRVKLSAASVADLAGESVKMHDDYLERLEENKLLSGQTAEQMQGQEDGELTTAREPIFSKGQSKRIWNELYKVMDSSDVIIHVLDARDPEGTRCRSVEKYIREEVPHKHLVFVLNKCDLVPTSIAAQWVRLLSKEYPTLAFHASMTNSFGKGSLITLLRQFSTLHASRKQISVGFIGYPNTGKSSIINTLRKKRVCTVAPIPGETKVWQYITLMKRIYLIDCPGVVPPSQGDSEQDILLRGVVRVENVEHPAQYVEAVLRRTQTKHIERTYELKAADYNDDAMEFLSILARKGGRLLKGGEPDVDGVAKMVLNDFLRGKIPWFTPPPKRGGVEDVDTDAATQIVEGREGRLGEMPGKRKADALAATDMGAEAASAAADHEESISTSDHAEDEGADQDGEASATDDDFEKFDDEDEEDEHDDADDSDSQADGHADGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CER6</accession>
    <name>A0A1C1CER6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CER6"/>
    <dbReference type="STRING" id="86049.A0A1C1CER6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02625"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02393"/>
    <dbReference type="eggNOG" id="KOG0106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="125" mass="14237" checksum="0666CEA2F57FFAA5" modified="2016-11-02" version="1">MADVSSTRLYLGNLPRNITKQDIEEHFGTHGAGTIKEIKLMNGFGFIEYEDAMDARDVVPAFHGTEFKGERLTVQFARGPRRKDDFAGPSDRNIPRPRRTIYRMQITGLQPDTSWQVSKPLVPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFN9</accession>
    <name>A0A1C1CFN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFN9"/>
    <dbReference type="STRING" id="86049.A0A1C1CFN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02502"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02117"/>
    <dbReference type="eggNOG" id="ENOG502S6JE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF5">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="42171" checksum="004F1B0A7E1F8021" modified="2016-11-02" version="1">MAMIRPRDHSSLDVTLMGHPEARNVGELWAGKTNIKERRRLQNRLNRRAYSEFPIQHARLDRLGFITGKRQAEQKLVRKRTMAQVGVEPEARMNRMLSVPGVTVFSLDVKHDQTRKGPISLTSLVSAAGMSSGEDAAVLSSSPQRHLRLLQSWCRQFEETMRRAGLMSVEPDQGSPTTDSDAVQLEEVLVEVGHVRYPDLIPNSEDQLINLMYYNVFRGLAKNIRALNLDIQSMASWDYDSPFVTGKVDVSTLAPDFQPTYLQRTISHHPCFDVFPDQVVRDNAIVHWYIEKHPLEGRLCMALAGRHTWHEIDLALKCGCILWGEPDVAESWEVTEGFARDWPFLVKGAVRLEAATNRYRAFRGEPPILFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFS8</accession>
    <name>A0A1C1CFS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stomatin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFS8"/>
    <dbReference type="STRING" id="86049.A0A1C1CFS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02501"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02099"/>
    <dbReference type="eggNOG" id="KOG2621">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13437">
        <property type="entry name" value="SPFH_alloslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="84"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="356" mass="38673" checksum="1E6BBD8B880C001D" modified="2016-11-02" version="1">MDSPRESGLDSGKSTTAPPVGFRPQNGGLIKVQPPRREDLQPSYAQTLQGDEEQNHGWYGSMINTLGSCVGFLGAIPCCIICPNPYKPVSQGNVGLVTKFGRFSRAVDPGLVKVNPLSERLIQVDVKIQIVEVPRQVCMTKDNVTLNLTSVIYYHITSPHKAAFGISNIRQALVERTQTTLRHVVGARVLQDVIERREEIAQSIGEIIEEVAAGWGVQVESMLIKDIIFSNDLQDSLSMAAQSKRIGESKVIAARAEVESAKLMRQAADILSSAPAMQIRYLEAMQAMAKTANSKVIFLPAANQTMPTDMSATFSSQNNGGEASGYNSKQNTGNAFNMDSGDGFQQAMNARVIENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG48</accession>
    <name>A0A1C1CG48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG48"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03767"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="86" mass="10138" checksum="8C2AAA433112FAED" modified="2016-11-02" version="1">MTLLAVPRETVTLEDRRVFQVDVKHVLEEKKSNMAAKMSEDEQETKAPQQDGEKCEETDLDVVHQRRRRETELALSQSHAQRRHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGF7</accession>
    <name>A0A1C1CGF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03635"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01797"/>
    <dbReference type="OrthoDB" id="10506284at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="298" mass="32343" checksum="D3F99829166DF42C" modified="2016-11-02" version="1">MCYTYVARPYCPCCCEFVKNVNEEAIKEQICPPHAPCKVRLQRPLPRSPRVEVVKTVCADCSWKRARELFAFSTAADRLRTAGSNLCNNTKACLPEKEPLLRNPISANGSYVGLGVDEIQPDTEAMEDDADFESQGACYLGTELMKELGEQKKQPTNPAENHPVAPSVAHCSSANSNQASCHCCSLQEAGSAHTRFIPMGTGMPGAPTMPKADRMRAAAAAARAASRPHPGAPGSTPGSKTSLSPRKTGVPRRTSRPYSTVTPPRPQQHRRHQRQNTLPTTLAHVGADKKEALTQSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGI5</accession>
    <name>A0A1C1CGI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Catabolite repression protein CAT5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CAT5</name>
        <name evidence="8" type="ORF">CLCR_03733</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGI5"/>
    <dbReference type="STRING" id="86049.A0A1C1CGI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03733"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10143"/>
    <dbReference type="eggNOG" id="KOG4061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160224">
        <property type="term" value="F:3-demethoxyubiquinone 3-hydroxylase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="159" mass="18405" checksum="E93208C922DD0403" modified="2016-11-02" version="1">MPLLVTAHPHLRPLMKHMYNQEAGHFKVFNELLAKHRIRPTAMYPVWQAAATVLGWTTGMMGREAAMACTEAVETEIGNHYNGQVRELFKWMTELKEKGEELDPELKVLIDEIKRIRDEELEHLDHAVENDAKEAQPYQPLTDVIRYGCRGAIWISERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGQ7</accession>
    <name>A0A1C1CGQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cys-Gly metallodipeptidase dug1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dug1</name>
        <name evidence="11" type="ORF">CLCR_03536</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGQ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CGQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03536"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04638"/>
    <dbReference type="eggNOG" id="KOG2276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="172"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT47703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="434" mass="47754" checksum="9F5EC068E57163C5" modified="2016-11-02" version="1">MGQFLASELESLGAEVQQRPLGKQPGKEHLDLPPVIIARYGNDKSKRTILVYGHYDVQPALVEDGWATKPFELTIDDKGRMYGRGSTDDKGPVLGWLNAIEAHQKAGVDFPVNLLCCFEGMEEYGSEGLDDFINAEAKKFFKDADAVCISDNYWLGTEKPCLTYGLRGCNYYSVEIKGPGQDLHSGVFGGTAQEPMTDLMTILSKLVSTDGKILIPGINEMVAPLTEEEKKLYGPIAYTMDNLYESLGSETSIFNDKEKTLMARWRYPSLSIHGVEGAFSAPGAKTVIPAKVIGKFSIRTVPNMESSAVNEAVFKYIRSEFAKLNSKNSLDVYCQHDGKWWVASPSHWNFSAAAKAVKEVFGVEPDMTREGGSIPVTITFEQATGKNVLLLPMGSSTDAAHSINEKLDRRNYIEGTKLLGAYLHYVAEEPMTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGY2</accession>
    <name>A0A1C1CGY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dual specificity phosphatase catalytic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_03353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGY2"/>
    <dbReference type="STRING" id="86049.A0A1C1CGY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03353"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04574"/>
    <dbReference type="eggNOG" id="KOG2386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14502">
        <property type="entry name" value="RNA_5'-triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000090">
        <property type="entry name" value="Dual specificity phosphatase catalytic domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF25">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE CATALYTIC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="558"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT47770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="673" mass="73702" checksum="A140A66670C99CD2" modified="2016-11-02" version="1">MKLNSLPSVGGLQLYQEFWGRPGSKPWTLATTTTLSLFLGFGALFLARSYLSTGRNPEEEAPSPESDHPVLKTHSTTRPYKTKYAEYSSIRTFYHPHAHAEKSQAIADLPLLVFIHGLGGSLPQFAPLLGSLVNIAPCFGLDLPGHGMSAFSPQNYDAYEIAAFCELWQTAIREVCEEHAHKRVLFIGHSMGCSIAALLATNPSFPLEVVGFVGICPKATPPSPSEAASARRFLSLPDPVLNVLRMLDRRGGVNSKSVERMAGKAAGVDLRRLQLAFNKSFKTPVWKRSALGCLPLYDPARKAIAGLPGREVWARIRVPLFLIAGEADTVTKPAEVAKIVSFLQESAAHNTKDATTAEQPLNTTDSIPDDTPTPGKPSQESSNDSTADERKFGTLPSTTETSSHNSKVVKTAILPSPAAHALMYDHSTYRTVAGLIEDFLARYVSPQLSLGWQLQQLTTSGKWDVKNLEKWKKVLPVSGAIGHPPEQGIFRALKTLREQDEIHTPSVFLKEWRDKIFAVIDISHDSPVYDTASLEKGGIQYHKFPTVSKVPPTIVEVADFIALVDRLRLEQQSPGSNGEGKNIGVHCHYGYNRTGFFICCYLIERCGYRAQDALDEFAAQKPPGIKHEHFIDTLFMRYHVGLKKAPTLVGAAMDDKTRSMAGTGVESVASTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH65</accession>
    <name>A0A1C1CH65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH65"/>
    <dbReference type="STRING" id="86049.A0A1C1CH65"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03561"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04500"/>
    <dbReference type="eggNOG" id="ENOG502S0AG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="552755at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037647">
        <property type="entry name" value="HIRIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410:SF2">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="385" mass="42248" checksum="34BC002CCFA5A6C2" modified="2016-11-02" version="1">MSASDSELSEASQTPTPPDHELEDALRRAVITAQKDQVDFSYKYIRTAAEGELGLTPGFFKSHEKWNQLSKQVIEEQMEAGPESHSPPPKPKAAGSRKKPAKRKSPETEPVPKKRQKTTKQAVDQDGSDDLSSPPSDLASDFEEGEEEQPKKKQRKAPAKARATKSKPVKGRNIKAAISEDEEDDRGEDENGATKADSLEAAVETKPAGKPADADASDSELSVLIDDKPPPKKRQQKDSSGSKPNKTTTKSSTKAKPEAEDPDQAEIKRLQGWLVKCGIRKLWGKELKPYETPKAKIKHLKSMLADVGMTGRYSLEKANQIKEARELAADIEAVQEGAERWGAVEDEDGGRGEKDVDSRPQPGARRLVRGARNYDFLSSDGEETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHK2</accession>
    <name>A0A1C1CHK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHK2"/>
    <dbReference type="STRING" id="86049.A0A1C1CHK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03658"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04443"/>
    <dbReference type="eggNOG" id="ENOG502SCPV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="9"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="265" mass="28844" checksum="6D2C653A6BB849D5" modified="2016-11-02" version="1">MAISAFEILDITELIFFFPALFVSAYVVYKHGHRKHLGWRFLVMICLFRLVGAISSLVSIHHPSQGLTITYDIMNSFGLSATLCTALGLLDRVNNGMDGHGLSPRVFRVLHLPSLAGLILSIIGSTNVFSSDPSDVSTGFSELKAAVCLFLVVFIADVLIAGLSFLRIAHVQTGDRRLLFAVVAALPFMAVRMVFSLLCIFANDPKWFSSWSLERNAIILHGAMGVLMEAIIVTIFICAGLATDPAVKPLAHEGKVAYDFSARSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI32</accession>
    <name>A0A1C1CI32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative scytalone dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">arp1</name>
        <name evidence="7" type="ORF">CLCR_04323</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the scytalone dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI32"/>
    <dbReference type="STRING" id="86049.A0A1C1CI32"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04323"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08243"/>
    <dbReference type="eggNOG" id="ENOG502SNND">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5281072at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030411">
        <property type="term" value="F:scytalone dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006582">
        <property type="term" value="P:melanin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004235">
        <property type="entry name" value="Scytalone_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049884">
        <property type="entry name" value="Scytalone_dh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02982">
        <property type="entry name" value="Scytalone_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024851">
        <property type="entry name" value="SCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like" evidence="6">
        <location>
            <begin position="15"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR024851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="173" mass="19972" checksum="2B83425CAD0EFEA1" modified="2016-11-02" version="1">MGSISSMPPIGKERITFEEWLDCSGVLYDWADCYDNKNWYGLMDIIAPKLTIDYDKVNNAKFTDLPAEKYIEMMADPLFLGDELISSQHLIGATKWEKVSDEEIVSHHQSRAAHQRFEDVRRKDVAVKGHGHGTVTTFYKKVDGRWKWAGIKTKVIWNEFDFEHVFRGVAGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ60</accession>
    <name>A0A1C1CJ60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ60"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04371"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08606"/>
    <dbReference type="eggNOG" id="ENOG502RZJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2679825at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="193" mass="22261" checksum="1B33FFBF65585037" modified="2016-11-02" version="1">MKPTKDKPRLYVALYPRGDTSTTSSFRNVSSCDSYHWALVVGPQTACRTDVGTRYHVAHLDEHSDKYLYEEQDIPLNVGAQKGLVRVAICKVSDEERLQSILRDMPIRGDDSAFNCLTWVREAFRRLHDDGKAVKTYLKSDDWDDVEKCARKYCKRKRDAGRFQEGNNNGAARAWDVNQISTFNFWENRETTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJG7</accession>
    <name>A0A1C1CJG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, mgt family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJG7"/>
    <dbReference type="STRING" id="86049.A0A1C1CJG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04845"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03234"/>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000072">
        <property type="entry name" value="Glycosyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="2">
        <location>
            <begin position="280"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="462" mass="50702" checksum="56E516929466B2BD" modified="2016-11-02" version="1">MTVQNSRPLVFIGVLPIYGHVERMLKVAKGLVQRGFSVTVLTGSAFKKAVEITGSKFVLTGGKADYQANAVFDSFAPGLQGAHGIHRSLLIDVIEDQHKVLQTLLEQAYSTGNEKVVFLQSCLYFGTSGLILGAPGLKPTGVIGIGHTSLTCSSIDTGPMGSGLPPDSSVEGRARNVQGQQKFEEAMAPVQNRYEELLRSLGATKEKVPFYFDAAVNLPDLFLQMSVPSLEYPRSTGTEGDLPSWWDEVVQHRKKLVVVSQGTLNINVTDLIIPTCEAMKDKDVLVVAVIHQIERIEAFTVPDNVRVARYLPFNELFKHTDVLVSNAGYGTVQQALFCGVPMVLAGVGEDKPETCARAAWAGVAVNLKCLRPTVEQLREAVDEVLSVPKYRVRGKELAEEYRQYDTIVEIEAAIHQLASRPRPRRARRRLGTDAALKVFRKLRRSTRGQHGRARRSSVVAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJP6</accession>
    <name>A0A1C1CJP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05234"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="146" mass="15813" checksum="296482064EB7BE2D" modified="2016-11-02" version="1">MVPRVEVEDPHVFRLVRVTSTSKYLGTRFSSYEYLAHSPATQATQLERKKLPYVPDPPPSARTFTALGGILDLVEQHNRSATSASRLNLLLLAMARILIATGGAAAARNNDPDSGGVRGVVAIRVLLISSRDSVLVPQDEWYDAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJQ2</accession>
    <name>A0A1C1CJQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Golgi complex component (Vps8)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_04500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJQ2"/>
    <dbReference type="STRING" id="86049.A0A1C1CJQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04500"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03153"/>
    <dbReference type="eggNOG" id="KOG2079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23413">
        <property type="entry name" value="zf_RING_Vps8_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="3">
        <location>
            <begin position="716"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="VPS8-like TPR-like repeats" evidence="4">
        <location>
            <begin position="1248"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1467"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT48748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1550" mass="172021" checksum="0D6FC38A4CE612B2" modified="2016-11-02" version="1">MNSTPDEGESFLRNQDETLSESADGRNSTIHDDGDVPEITPELETQEVVGVEASGDEVGDGRDTTDDEEELPDPDRVDDGSPVNGTTNVLSNDDSLSTPDDTPSRQGSILSSSLSDAGSIRSPARRGSPSVPHRPFDIRFQSRLSSSQLSPLRSASPAFLGAHSRHSSAASLGLQTPSEPDEGINPWDVIRWNKFKKITGQAFSEIGRRNFGSPTCLAVADQLVLGTSKGVVLVFDHHQNHKAIIGSGTKAAESGPVTALAISADHTTIAVGHATGHIFTWEVARPARPFLHIQPMDISQPQARRGDGHIVGSTVLHIGFLGYRHTALVSADDKGMAFSHLATRGMGAVSRVVRTTRILGRYSEVVSRNSRPQKKSSVLAFSPLPLGNIEQGTDSLGLVAMLTPYLLVIVSTTPVAQTQHKAARPKEVAAHSAMTAALAWFPAIKLKSEQSEISRTKLVYAWSNILTVLEVHEIQGEDEAGKDKPPELQFLARSRYQAEEAIVAVQWLNKSVLAVLTITQQLLIIEDLTMHVTEAFDLLKKNVYHADLYSQQLRAIIEQLDEEDTSMHGVVADAFHMSFRAYKGRLFLLGVNDIWTGVLTNWADRLLAMINIGDFIGAIRLAAKYYQGEGEKATIGLPEDDNMRASIVREKLVEMMTASLKYAFGKNQQAGNDQIEKPQMVELADACIKACLIMEDQDFLFEEVFSWYDEHEQGPLFVDVLEPYILDRRITSVPPPALKTLINHFAQTHTPSVLEEIICMLDTSTMDIDQVTTLCKRYGLYDAYIYVWTKALHDYTTPLTILLDFADGDEGLRQQTVGVADRYALAQKIFPYISFILTGRVYPTGNTMDDDEAASAKGQVYDFFFSGGSSANGTSTRRNDAGLKAASSFENLARVLRFDTASFIAAMNEAFEDSYLNAADDDSPNSLNISQAWVSRTYTRQYVVRILLEIMSTNFDSDDSIYLDMFIARNLAKYPQYLVLSGTVLHEIFGRLCHYPEDDMREDAQLSVEYLLSIYQPPNVLEFVPLLRQARFYRVLKAAFKQERQYSDMISTFFLDSEDQESVFPAIIECLRAESPLTEQQRKGVREAVRQHAFDLVAMDVRRSAATIDEVAPDKHHIFIQVLADDAFAQYEYLRTILEPKDKLRGRRTYGHALVELYVRLLCQFDPSHVRDYVESIKEGDIRLAEVLPTIEDSGIIDAVVILQLRQGHVKEAMDRLTKHLFFLGSTLKSLKTEFIAQGDDASVHHPSTGVLEALEKYARVGIWLCQGQMKNAPKTPTVSKSPRRTASATRALSFEENLWLELILCVVGIARDCSAKGVLDAATGQGDRDVEITTVLRTVIQQIFTALLASTASVRDAAAGRDMMFLRILRAFLSQAAETSPSLSELRNVISSIFSAYAYEESLLALSNAMLDKDVFVHLDEVTRLRLRGWRPRGQVCEVCRRRIWGPGIGERVWEQWQKKEEARLDRRRRIQQGDPTHEEDGARGKGKATVGVSSQEALESESPGGSDALREDIGPLVVFSCRHVYHQKCLGQAAGEDGVPQLVCPACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKB7</accession>
    <name>A0A1C1CKB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_04590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKB7"/>
    <dbReference type="STRING" id="86049.A0A1C1CKB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04590"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03035"/>
    <dbReference type="eggNOG" id="KOG0596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14131">
        <property type="entry name" value="PKc_Mps1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000377">
        <property type="entry name" value="Checkpoint protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027084">
        <property type="entry name" value="Mps1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="490"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT48872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="849" mass="92857" checksum="6A2B35A9BEC79C88" modified="2016-11-02" version="1">MAAYASPSPAALAVGLSNSRRPLQATTRPAAQRAPAVPELIATHKKPHLDRSFTGDSSDDEDLAPIKLSAEAQAILGEDEQQLEAEKENIVPRVHPTTSSTSTSQRRQSKGTPLEALRSSSPPPQRDGSPAPRVIRVTSSVRPGAPGVLGRDGSFMYKIHEKSTTRAPTTRPESETPGPPVRRIRISNGRRASRSPSSDQAPQPQEEAQAEDAPYTSKRSTSPRSGASRASLEEHNSAMPSTATRSRKGDENGAHSTMRVRRLGGALLNKPVRRGMVRRHSDDDDANMEDHPGAATPEMEVGRRAPEPDLQDLPDDLLALQGSPQPIKPTRPSPRTTSPLQVDVQTGFDRPPSRPGSLLRTQPTPPVPSSHPSLKSSSSQNRPVFKIPPLPSLSAQDQENDPPPTFRRTRPSAAILDIHEDGGDPDRKAPEPAPLQISPSRQPLAPRSNNTPHRPAPAPPPKMSILDAATSNAGSRNKKSVHYVLNGKTYRRLDCIGRGGSSRVFRIMAENYKIFALKRVNLEEADMAAIAGYKGEIDLLKKLENVDRVIRLYDYEVNEEKGVLNVMMELGETDFNKMLNEQLKAENAKLDITFTRHYWKEMLECVQAVHDHDIVHSDLKPANFLLVKGQLKLIDFGIANAIQENTVNVHRENQIGTPNYMSPESLVAVGATQGQGGLPGAKVLKLGKPSDVWSLGCILYQMTYGQPPFAHIQKQFERIMSIPNPKVEIQFPSTGIGGSVVPFGLIKTLKRCLTREQSLRPTIRELLSATDPFLNPVAISPEMLGRVIGNVVGYCRRREEALKAKGEMQCQVGEDGKEASCLPTDGEMVGWPGAFYEKLRQANLEGTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL59</accession>
    <name>A0A1C1CL59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL59"/>
    <dbReference type="STRING" id="86049.A0A1C1CL59"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05285"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02697"/>
    <dbReference type="OrthoDB" id="4158019at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="82" mass="8175" checksum="4A2A2B60AA3CB2E6" modified="2016-11-02" version="1">MALNAASHNTTGEPTGSPSGPPPPVSSDITSAAKGSAAKDAMGQNVPGTDLQNNDKGQTVMGEAGKEKTAKESTQDNTEGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLJ8</accession>
    <name>A0A1C1CLJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dimethylaniline monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_04670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLJ8"/>
    <dbReference type="STRING" id="86049.A0A1C1CLJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04670"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03294"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="498" mass="56404" checksum="A00DC701EDF154DC" modified="2016-11-02" version="1">MHILFLKSLVSYKRARRRHTATGGRSRVSETTGSSRSTLEHAESCASSTSVRGRRAFCFSKFARDRLEKVEFQVDEKNDDIGGTRDAPVTFPLSATSSRGIGIPSGRIIIPILPRFGGISRVSFERDNLMKHIKLRHQIIAAKWEEQEGLWHVRIHDEEQGREFTDTCNVLVNGGGILNNWKWPDIAGLHSFQGVLQHSAHYTEGLDLKAAGSKIVVKIASEVDHLYTWVRSPTWITAGFAQKFASNGGGNFEYTPIQKQLFKENPKLYLKYSKMIESELKQRFKFILKNTPESKAAKEYAIAEMKQKLADNLESMEKMIPKDFDVDCQRPTLMHVLSSVLDFWPYAVIQPGNGFLEALNRENVTVFTKLMTTVTSKGFIDHTGQEHEVDIIICATGRSFDTTWIPRFPVEANGTSLAKLWRNEAPSYLSVAPPSIPNYYMMGGPYRPLGYGSFLPILEILARYIIQIIDKMQTDRIKALTPRVEAIARFKQHADLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLL0</accession>
    <name>A0A1C1CLL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_04820</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLL0"/>
    <dbReference type="STRING" id="86049.A0A1C1CLL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04820"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03302"/>
    <dbReference type="eggNOG" id="KOG0895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="18"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="316"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT49383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="473" mass="54247" checksum="DBEA75101C393153" modified="2016-11-02" version="1">MSNQTILRISRVRGWRRKDARRDANARQEITQIQQGSDLSIAVACQEKDVRHVRALIIGPHGSPYEYGFFEFSVNFGSEYPSKPPKVEAKTTNGGRTRFNPNIYAGGKVCLSILGTWHGERPGEEWSSAQGLESILWSIQSLMSNNPYENEPGYENAKGTEDKKMNDLYCAKIRHETLRIAVIQKLEEALGIQPDGSVALPAAALRWSSDEDDEEQSPGLLETQPKLKFAPFKDLFKRRFLWYFEHYMSTIEQYSSKNKDGTDFTKMPFEGGGNSMDGKFKYAELGKRLVRIKEVIRDETNNWAVEGLAMKNRESSKAATIQRQFEQLADYLQRKNLHNVNVELDKCNPFVWILTYLGRPGTHLDGGIFKVRISISPRFPDEQPRVRVETAIYHHRVSKDGVLCYFPKESDMLRNHVECIVEALEEESPPYDPRTIVHPEATKLLWGSEGDKKKYYRQLRRSAQRTTEDGIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLL2</accession>
    <name>A0A1C1CLL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05239"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="101" mass="11281" checksum="CAEA58BF5FF278AB" modified="2016-11-02" version="1">MAASQRPRKMPNIVFERPEIIRVNTVGPEHADNLGPYFAREKDFKQGVPYVQGAAGPFLHINEQGSHRKSSAFGMMSKAQTSRAALFPSQQQAQGQTYDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM05</accession>
    <name>A0A1C1CM05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative c6 transcription protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_07197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM05"/>
    <dbReference type="STRING" id="86049.A0A1C1CM05"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07197"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09746"/>
    <dbReference type="eggNOG" id="ENOG502SIWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT49482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="415" mass="46205" checksum="BFEDCB24CB7A3E72" modified="2016-11-02" version="1">MDSARQGDETDDPIQRESQIDQILRRKRKARKARVCYPCRQRKVKCDYGTPCQRCIDREHPELCSYQQTPKTRSLDSAFTSSPAEVTRPVAAEGRRPEDKNLWSELESVKALLQDVQGKLQNKTTSHTPAPSNLAEQDTRDVYPTPSGVQAPTELLGDFVHLGRHSVPAMVMALGTRSDEVAVQDIIGKSALPLFGLDNESATYPFVDLWGLPTGSSTRVQEICKIVPSDAECFQFLRQYRDVAHILYPAVVDIDQLEADLTQFLISRSSQQLPIDNYVNASSTVYGKSLHWLSLMFACLASGCQASSLPRKERHLTSQVYVCCAYECLRCVNYLCHPTVLDIQSLLVLGNVIANNMNAGVAWSLLGKDIHVRGAAYGFSPSIGLTIRLAITIGLHEATDSPDHSTEMHSRRELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM32</accession>
    <name>A0A1C1CM32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Brl1/Brr6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM32"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07407"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09773"/>
    <dbReference type="OrthoDB" id="4160347at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650900" description="Brl1/Brr6 domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="35669" checksum="7E22A352A916D08A" modified="2016-11-02" version="1">MSSQRRMRLLDCFLPLMFMLPWALASPVPEIFPPEADTLSFAELAQKAFLRILELGFIRGVVVSLSILGALVCLLIGTLRALAAYLHHHDTRLSEAYEEVHACAGGEKEVQDEADCRRASVIEECQPCSLQRLKQSRNSRYIIANPSTPITKVNVHAFPRRAAVVMSPYSPSETRFLTPVRSTSTPLRSALSKSPPSSKRLSDARSYLSGPRSTSTSTCLMPSPKSVRWADQIHVSITSTLEMSVRRRPKEDQAGTAPEIDIATRTIGNRNQHQFDVLDILSHPTHHAEPLPAHEAFLATPAIAMGDGPSDSSGESCMLLEGDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMC4</accession>
    <name>A0A1C1CMC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alternative sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_06872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06872"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09854"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF32">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="46"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="474"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT49601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="516" mass="57771" checksum="6F3C91B2925FC680" modified="2016-11-02" version="1">MSPFDKKSPDPDGYPEPGPDEEPLALEVDWTPKEEANAKRKLDFIIMPLLTLGFFCLQLDRGNIANAITDNLMEDVGITQNQFNVGQQMLSLGIVLFEIPSNMVLYRVGPGKWLTLQLFLFGTVSTFQAFQNSYGSFIASRFLLGMTESGFIPGGLWTLSTWYTRTETAKRVMFFYFGNQFGQASSKLLAYGILHMRGVAGKAGWFWLFVIMGIFTIASGFVLGFFLPDSFKNPHSTFLPRVRMFTDRELHILRTRVLLDDPMKGKKKKRIGRAGFKKAFTNWRLYVHVLVTLCNNGPQRAFDTYAPSLVNGFGFGQLSSNALASVGLFLQIPTSFAFSYVSDHFNKRGPTVITGLSCHLLGYIFNRGFTELNGSRGAKYFGVIWTQTFGTFSHPLNIAWMSLTCEDSEERALAMAMVIMGANIAGIYGAQIFRSDDRPRYRRAFSVNIAVLAFGLSLAIGRYVDDRLLRRKGRRQSTLGPGRSPSRSQSMSVQDSEKTGTPPVDEQRKAVVELPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMH3</accession>
    <name>A0A1C1CMH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">(R)-benzylsuccinyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_07046</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMH3"/>
    <dbReference type="STRING" id="86049.A0A1C1CMH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07046"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09925"/>
    <dbReference type="eggNOG" id="KOG1469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="145"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="259"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT49679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="416" mass="46579" checksum="36B30F2FE862C47F" modified="2016-11-02" version="1">MEPVRVPALIADKLRPHAKETLAKVKKFVEEECIPADEVFEAQLALHPDQRWKSMPPILEDLKKRARELGLWNMWMHSHFQEGPGFTNVEYTLMCETMGRSHVAPEAMNCSAPDTGNMELLAKYGTEAQKQQWLRPLLDGKIRSAYVMTEIDVAASDAKNLALEMRRDGDEYVLNGVKWWISSAGDQRCQLYIIFAKSNSDDPNPTKRHSIILVDSKTPGIEVIRPLRVFGFDDAPTGHCEVHFNHVRVPASNIILGEGQGFEIMQGRMGPGRIHHCMRAIGCAERGLEYLIARANQRMVHEAPLANKGVVADWIARSRIEIDAARLLVLNAADKIDSGNAKDAMSEIAMAKIYVPNVALAVLDRAIQTHGAAGLCQDFPLARIWTYLRTVRIADGPDEAHAAQLARTENKRHRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNB3</accession>
    <name>A0A1C1CNB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNB3"/>
    <dbReference type="STRING" id="86049.A0A1C1CNB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07472"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08857"/>
    <dbReference type="eggNOG" id="ENOG502R2VP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4159165at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="1">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="287" mass="32220" checksum="B32797748D967978" modified="2016-11-02" version="1">MAATTTNAPGWAFGNAVLVAIDIEIHCRKHYPKVGSPQDRVSEIGVASFDPRRVRFADAGDRAKNTWSSIKACNFAVTENTHIPGVGSHARHCQDRQWLLGANAGVKATDFDFGSLYNVSRFHVKKAFVNKIRTLLGDHPPYNNDTPYHNNREVVFLFFDQQNDLRWLQGLGIDLSTEFPNSRIIDIQRGPLAAAIGERMRGKAKISAEDMYKYLRFETVHMHNGGNDAVWELRAYLAELTLTDPQTHETRIPDEATTLNKDGVVVKEEPTYIAAPEVMVDGEVWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNJ3</accession>
    <name>A0A1C1CNJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07841"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="78" mass="8459" checksum="1A3174B5E779FD8A" modified="2016-11-02" version="1">MAFGRPVQLQGHGWQKLRFSTPPRAKEVLEIGHLLDNANPNCCFIQGSLGAKGRLDLANRLLYPVQSVYSRGPALAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNL7</accession>
    <name>A0A1C1CNL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rapid response to glucose protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rrg1</name>
        <name evidence="1" type="ORF">CLCR_07349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNL7"/>
    <dbReference type="STRING" id="86049.A0A1C1CNL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07349"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09012"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="433955at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF156">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="343" mass="38097" checksum="ACF6AAE7A425CDCA" modified="2016-11-02" version="1">MTPDLDSDAVDSLFQLGNAVHDLPQLYQHPSAPALLEALDLFLSGQTSFASTGTGASGRRRVAEQGAPGYLTSIVSSSLRWIEDEEAKELIWTAASARLSERSGRNAMPTMTRSFVISQGPECGDLVIQLHEPTLTEDNLGLKTWTSSLMLSRRLREVRRLIPGAVDRVLELGAGTGLVGISAACLWETHVLLTDLPEIVPNLQQNLEQNKEVIQEHHGSVESRALDWADETDTPGSIQDRFKVILAADPIYSADHPKMLVSTVRRWIRWETVARFIVELPFRDRYDEERRALRMILAGLDFGLVSEGTDVGHDDWHGRDGSPAEVTCWWSVWKPNVPQSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP63</accession>
    <name>A0A1C1CP63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General alpha-glucoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06808</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP63"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06808"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05717"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="18"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="522" mass="57625" checksum="B04337A515278EA5" modified="2016-11-02" version="1">MAGRNDDSIAANWRCFVACAIITLSPFQYGVDFGLIGGLQAMPGFLKIYGYRAPETPIGWNLTPLRQQLISSLMTLGAFISSGAAGFAAAKLGRRHCLWIASGLCCISNILMMATTHIGALYAGRLLIGLANGYFMTFSQLYIQESSPAKYRGLFLSAFQFFTSFGTLIGTIIDYATSKRPDKSAYLIPLGIIYVVPAFLTLAMFFIPESPRWLILQGRHEEGIKSLRWLRPNGADVDAEALVIRTAIEKEMELKSSVGIWDMFRNPVNRRRTTLAVCAVTLQAASGSMFIIAYKAYFFAMAHVSNPFGMSCILSATGLIAILINSTIVVRYGRRRVLLMSGLVVCGILQLIIAVVYDKEPGTKTTGKVIVALVTLYMMSYNGMIATYAWLSGGELPTQRLRSHTFGLAAAIGFLGAWLTTFTAPYFINPASLDWGPRYGYIWFPSCVVSALWVFFFLPEVKGRTLEEIDEMFEAKLPARKFRKYKCVQSAVILEEKLGRKSIEEEVWGDEKATAEATVATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP67</accession>
    <name>A0A1C1CP67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_07597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP67"/>
    <dbReference type="STRING" id="86049.A0A1C1CP67"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07597"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05728"/>
    <dbReference type="eggNOG" id="KOG1754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT50261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="130" mass="14751" checksum="DD5BE88A480EDFF5" modified="2016-11-02" version="1">MVKTSVLNDALKSINNAEKAGKRQVLIRPSSKVIIKFLSVMQKHGYIGEFEEVDDHRSGKVVIQLNGRLNKTGVISPRYNVQLRDLEKWVVKLLPSRQFGYIVLTTSAGIMDHEEARRKHVAGKVIGFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPC7</accession>
    <name>A0A1C1CPC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcription factor (SPT8)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_06827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPC7"/>
    <dbReference type="STRING" id="86049.A0A1C1CPC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06827"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05657"/>
    <dbReference type="eggNOG" id="ENOG502QS8F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260946at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900237">
        <property type="term" value="P:positive regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="131"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="476"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="654" mass="69986" checksum="41A50404B0F3F0CA" modified="2016-11-02" version="1">MPAFDEDDERSQDGSFDNDNDETMQDLDDADADGDIDGDADIDQDGDGDGDGDGDGDGDLDIEGDGDAEGEGDEDDDAESQSEQSDNEDTSGEPGATQDGTQQTASAQADSSRGVATASNISAEYLNAWSYDIVPTVAAPHSTSINAVCTTGDMRWVFTGGSDGYIRKFNWVDSINNKLALTVAQRHPFVDSVVKAGVLMSYWENWDARPNTTQTLSPVYSLACHSQALWLLSGTASGPIRLQSIRHDEGREITSLQKHTSAVSVLTLSSDERSLLSGSWDKTVLDWDLNTGQVRTTFAGSAGQISSIETRPVSSVPVPAESGEVVVSNGTFSSNDGKSLTNGIKSDLPSQNTQEHPTVATPDSLFGDGGDDDLFGDDGGVMANGGGLTDDFGVEDDEMSRAMANGPQPEDLVDHPMLDSVDSTNDAAGALPDSSQHQVSAGELTNGIPDSTEEPITNGLPHADDLERHVEDEVTTQDSEAPHTSDSTFLATSIDGAIRVWDRRQSKPVARILPRNTPPWCLSACWSPDGNFIYAGRRNNTVEEYDLRKGLKGPERVFRFPNGSGAVTSVRAMPNGRHLICASYDILRLYDLKESHASRSTVPFLIVPGHRTGVVSHLFLDPACRFMLSTGGNRGWEGASAEVLLGYEISVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPL9</accession>
    <name>A0A1C1CPL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atg3</name>
        <name evidence="13" type="ORF">CLCR_07284</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Monomer. Interacts with ATG8 through an intermediate thioester bond through the C-terminal Gly of ATG8. Also interacts with the 40 amino acid C-terminal region of the E1-like ATG7 enzyme. Also interacts with the ATG12-ATG5 conjugate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPL9"/>
    <dbReference type="STRING" id="86049.A0A1C1CPL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07284"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05557"/>
    <dbReference type="eggNOG" id="KOG2981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="93"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT50446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="370" mass="41140" checksum="22C74A8F62C1573F" modified="2016-11-02" version="1">MQYLRSGLDQLRDRYAPVSHKSTFRNTGQITPEEFLLAGDYLVYKFPSWSWSDASSPARRVSYLPPNKQFLVTRGVPCHRRLDENFAGGHGAADDLVRDGFLGGPDDETESKGGGEDEGWLRTGGTTEKEQEGLRGEVRTMSESGQLGKKAVEDEDEEIPDMEDEDDDNEAIIRDKSEGAAAPLRTYTLYITYTPYYRTPRMYLSGYLSPSAPLPPHLMMEDIVGDYKDKTVTLEDFPFFDNSVKMASIHPCKHASVMKILLDRADAALKLRLDKQKADGASSKKEISGMEGLIDDTSNLKLSEQKRGHEAGVKAASGGAGDEWEVLDEQESAEDESEKVAIRVDQYLVVFLKFMASVTPGIEHDFTMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPN8</accession>
    <name>A0A1C1CPN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07608"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05538"/>
    <dbReference type="OrthoDB" id="4147939at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="210" mass="22127" checksum="DF41CEF6DFA5AF35" modified="2016-11-02" version="1">MDGSPRGTKQPQPDTLDPSDGRSPEPTSSPCRPYGSPPIKMPMPLHPRTAGILRSESPLIGQHLRASSQTPLGRTSAPLGRSANEQPPYSFGSSVSLDPRSLSPIPDPVALAEIKRMVPQIQSTKEGLRNLGGMIEALGAYVKHASNAPAPASYEDQMSNSGRTSQTMSEGDFSNTLAGSAFDAFLNDLEDEEGGDTGIAAGNNTQAENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPY4</accession>
    <name>A0A1C1CPY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein hob3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hob3</name>
        <name evidence="5" type="ORF">CLCR_07425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPY4"/>
    <dbReference type="STRING" id="86049.A0A1C1CPY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07425"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05442"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT50570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="261" mass="30095" checksum="2CF86F7BC4A01A94" modified="2016-11-02" version="1">MSWAGFKKGVNRATTQVMMKTGQVERTNDRDYEVEERRYRTMESAANRLQKEAKGYLDSLRAMTASQMRIAETIDAFYGDAGTRDGVSRSYKQAVEDLDAETIKALDGPYRATVLEPISRFCAYFPDINECIKKRNNKLLDYDSMRSKVKKLVEKPDKDVTKLPRAEREADLAKQAYEQLNEQLFTELPQLIDLRVPYLDPSFEALVKIQLRFCAEAYSRMAQVQQYLDPETREQYARGDLDNRVEQVLSEIRDLTIAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQA8</accession>
    <name>A0A1C1CQA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07650"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05341"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="56"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="160" mass="17462" checksum="6D1EE493E81AD758" modified="2016-11-02" version="1">MPASPTHPAPGYFPGFPMSRCLEQGYNHGQRWGRVSSHCSYSALTTLFSSIALTETPPTVQQPARRDNPHHQYVLAPASSYKTLETWVIRVTALILVVLPIWMLSPSSVAKQDLILTSILVGCFMSLTRFIRPNEVQIVAAATGFAAVLVALVQLRQSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQF7</accession>
    <name>A0A1C1CQF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyl hydrolase family 43 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_07262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQF7"/>
    <dbReference type="STRING" id="86049.A0A1C1CQF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07262"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05268"/>
    <dbReference type="eggNOG" id="ENOG502S9PF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3879658at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08999">
        <property type="entry name" value="GH43_ABN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF5">
        <property type="entry name" value="ENDO-ARABINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="384" mass="40719" checksum="E3A34D1EB4D8733C" modified="2016-11-02" version="1">MVAIPTYMMASTAATSLGPLWPRNSVIRSPRPDPIPQTTSTTVISSPDSDPFASIIGPHISSNFPDPAIIYVDGMSYAFATNNRQPAPNHINIQVAVSTDNQTWTLVDQHDALPNLGAWETGAGVWAPDVVQLDDGTFVLYYADNVVWSPAHHCVGVATSQSILGPYIPQASPFACPDVDALGGAIDPDGFLDESTGKRYVVYKVDGNSIGHGGACGNTVAPIVPTPLMLQEVDHDGITPIGDAVQILDRDAFDGPLIEAPALHRSAEGVYFLFFSSNCFTTPQYDVSYATATNIYGPYTKSSRPLLVTSDADLTGPGGMDIIKGGGMIVFHGHMTVNNDPILKKEAETLAATDNTTIANVAVPLVRGMWSGKATFQGTDILLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQN4</accession>
    <name>A0A1C1CQN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear cap-binding protein subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cbc1</name>
        <name evidence="4" type="ORF">CLCR_06698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQN4"/>
    <dbReference type="STRING" id="86049.A0A1C1CQN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06698"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05245"/>
    <dbReference type="eggNOG" id="KOG1104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000035">
        <property type="entry name" value="snRNA cap binding complex subunit (Gcr3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000045">
        <property type="entry name" value="snRNA cap binding complex subunit (Gcr3), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 1" evidence="2">
        <location>
            <begin position="244"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 2" evidence="3">
        <location>
            <begin position="451"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="755" mass="84085" checksum="E9ACF5BB7F0E3B1C" modified="2016-11-02" version="1">MCLDLTDDSTIEQPLKIPFVAAIILLANALKPEFTPEVLARIGGALQKYLNLGHWREVKLYLRLLGCLQGMFHGDGVFPVLDELFSRAADLQMKSSEDSLGLELVKIILLTIPYTMASSATGFESQASALLEKTDIIASTAHPLEALVDPFPSPEPGAPAGSESALALLQRHMQEEAQNSWELACLPRPWKRNRSGEEEDPLEAAQKQPFPQITVPETVQLGPRSLFPETYSSVYAEQDIETVPASSDPAALLIRDALADTINVLHFNRAVAAKFLIDVDCYFAPDTFVKRATPFDKLREVAGDKATWKPEDVIVDAAFAQLLQLPAPEHKLVYYHAVLTEACKLAPAAVAPSLGRAIRYLYRNLDRMDMELSQRFLDWFAHHLSNFGFTWKWTEWVDDVALPDVHPKKAFMIDALEKEIRLSFSKRIKGTLPEPYQALISEAKEKDTPDFKYNEESTPFSAEAQEIAQLIRRKATHDEFTPILQKVEQDAASQGLPDPALAAVDAFMTSICWVGSKSLSHALACTERCKDRLLAFSASSSACRKQIITSVMDYWRDQRGVGVILIDKLLNYQILTPPSVIEWALIDHVDRGRLLATTWCYELVNNTTGKVAGRVRSLVAAIRTPGLTEEQKNELQSTLTTELEGMKSLFATIEDAVGSIRDGNQDEMIESSDALRAEDEALLRNWGGRWARVFQRKGAVEESWVREELARPIPEPEVKEEMMKDEHANVNEGRGEVNGGTAVNGEDRDGLDGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQW8</accession>
    <name>A0A1C1CQW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enterochelin esterase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQW8"/>
    <dbReference type="STRING" id="86049.A0A1C1CQW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08145"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09544"/>
    <dbReference type="eggNOG" id="ENOG502QVM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="184793at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050583">
        <property type="entry name" value="Mycobacterial_A85_antigen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48098">
        <property type="entry name" value="ENTEROCHELIN ESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48098:SF3">
        <property type="entry name" value="IRON(III) ENTEROBACTIN ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650993" evidence="1">
        <location>
            <begin position="28"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="700" mass="75970" checksum="11C2E5F6A1A50DC5" modified="2016-11-02" version="1">MRFLGLSYGNPAAVAALAACLPVAALAQATSSSSGLAVQLSVANGFLNGTTDGHVTVMFAPSGTDPMEDTDVTSSPNLFFGMDVFGVATVSKMTMASTSILDTAGGVWGFPVVSLDDVPAGNYSVQAYFTKYETVKRSDGSSVSVHFPCGDGAPNIGGFGSLFTAITDVSVTGDAQTVNLVFNNVTATEAFTGKEIGGCSQGNYEDTETLKYVKIRSEALSKFWGRRMYVGANIVLPSGYDPNDTATRYPVIYSQGHWGADAGPFRYPTANFSDAWDNGTIPGANGQPDRPTPKMILVSLRHESPWYDDSYAVNSANHGPFGDAISEELIPYIDEHFNTIPEPYARIQVGGSTGGWESIASVIFRPDLYGACFSSYPDSLDFHRHQDIPLYSNTNAYLRANGSAIPSIRDFENGTQVILATVAQENHWELTFGTSSRSSLQWDVWNSVFGVQGLNGYPLEPWNKITGEIYPAAVEYWRHMDLADYIVTNWNNSYNLGEVLRGRLYVYVGSWDDYFLNEGVQEFQKRTDAVGGPGWANITILPEKPHGGNYQDREIWDYLELVYNWIQDHGPNGTTPLPRNVTMSSSRGNNFTEVLAYGGHQAALKRQAPPSITGGDNCDGAGGCVFQASVGRWDPGVELEAQWVVSGKPVGEAFGVAQGESLSYAPTTATKRSSIELWVTGRKMGYVDETRKSNGIMLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQZ6</accession>
    <name>A0A1C1CQZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQZ6"/>
    <dbReference type="STRING" id="86049.A0A1C1CQZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08008"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09552"/>
    <dbReference type="eggNOG" id="ENOG502S18D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="780" mass="86319" checksum="785211E92FF47A9B" modified="2016-11-02" version="1">MKKLVHRFKKREPRKPDTKRGADGKILQDPALREPHECGSPNKALEAAEAGAIGTYSGFDDWLSSFTPAAPTAAELPDERVHDTSKYQPARQPEVTIEYTSQVLLDDLITIILDGVRKPNYPGDFIARLLIPIYFTLQQLNDLLLDNGFAPVLAAQRQGCDGFSGQGLHGHWAAMVVNGLSCYSRKHGLRINAAEAFSTYLIGLEKVRVECRDSCLVINDDEMVISFQRTLRLPDDDQVYDLPEGFGRLPLFNISSFSKKLNDSKDPNLTTISKKGGVFLPLYQREATWIKFDTRSSQKPFAVRVFVGGINAISGRPWDASRAKGDQDYITVPPQEFLDGIAIDHQTVRQFVAMPLGSGYSIEQQMTGKEDRGGFQMEITPSGSQLRLSRVEWSSTELKAASSPAGEAMMPGDLVRVSEPSTSHHMMRSSEDTGRYSPPLRTYYFQGLAASGDGHNQWRSGCQLQMTALYALNLCIRFYDLDRLPSRHFITQMHTEARPWESLLSVLCQIDNHELEDYHRDSYLYQNRLVDDVQINKLGIKDGEVLDIFCGAKDVHLSKSLSFAQAPTKSLSREGKGTPMPHPGVTLGTGRSGWDMVIAPGARLRQKIYRDPWPPGIWRREQSVLVPIQILNSVAFESLTGMLPPPTPITAEAYVKAGIPFYTTGDDDVEAVVVDAKGTFETIKSVGQLDAEGEQINPGATLSGKSHKIACTACKINLCDCVLCGRQVERVIGFSAPMALPGYETIDLTRTTVHVLGPMTGDAAFTPKAWYEVTDAIELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRM4</accession>
    <name>A0A1C1CRM4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GPI anchored protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08712"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06908"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF32">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651001" evidence="1">
        <location>
            <begin position="20"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="359" mass="38595" checksum="0A24C73C312DF749" modified="2016-11-02" version="1">MVRLSLALLLGGVASSATAYLQYSTVTGYFLQDDNSTNATTFDYTATNFGLINQTYPTDGANGASLTQWQRFAGLIANLTKTAPANVQYKLLFLGRHGEGWHNAAESYYGTPAWNCYWSLLDGNATAIWSDAHLTDNGIAQAQTAHDFWLSRIHLEKIPTPQTYYTSPLYRCLSTANLTFSGLPLPKDQPFIPTVKAFLREGISEHTCDRHSNRTYIHAEFPTYTFEAGFPETDQLWTGVTAETSTAQDARSKTLLDGIFAADKSTYISFTSHSGEIASLLRVLGHRTFSLSTGAVIPVLVKAEKVAATSTISAQPWTASPHCTVPPVSSVSGGANGGCVCPGGVAPVTTTLPPFAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRX2</accession>
    <name>A0A1C1CRX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative atp synthase f0 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRX2"/>
    <dbReference type="STRING" id="86049.A0A1C1CRX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08811"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06829"/>
    <dbReference type="eggNOG" id="ENOG502REZ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3342455at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08611">
        <property type="entry name" value="DUF1774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="294" mass="32976" checksum="6AD57B3CB5375952" modified="2016-11-02" version="1">MALTDYNPFAKREEFTPRNLLAYKILTIVSWLVLVIFGAVYTFQKPTDCSKHQHCHTIWGQNNHNPSGFSVNSVLTSIYWVVVLIFQAHYVRFLWSAEKDYVTSAANVGSHFILHNLLTFGFIMLWVRGYFWQGELLLIVNLFNLTALYFGHSATPLIIHAPIVSAPLAWNYVAILWNGAAMVGHNRTHLPARIVANIFIWGILMLGAFFLAVFKDYTIGLELALLALSLALGQLATKVVAFQWIFAFVIAAVLFVLSLAVAAPKLFGGDRGARHEGAIVSEDRERAPLLDDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRX7</accession>
    <name>A0A1C1CRX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09173"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="171" mass="19121" checksum="05039695B61CD3EC" modified="2016-11-02" version="1">MVVGQGQASFAPELDFHPVRPLDNLENDVLENDVLESRTQTEKTPQSFTNQVALVDRTPPPVSSGVLLRSEMCSNMLAASIFICTNKPFTIHHSLMNYGPAPKPARLIDRLLHEPEVDPAKYVDAWMSKLKSSESVHQNAIVVDQGTVEGFEGFEGFDLGEYTYRTQRRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRZ5</accession>
    <name>A0A1C1CRZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09216"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06818"/>
    <dbReference type="OrthoDB" id="4161430at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="161" mass="18317" checksum="6A4C75B0138465BA" modified="2016-11-02" version="1">MGYHESSTEWNARKSDEIPLFSIVADITHRQTRPYDRPVVAAVVQGGALENGRHNTQQADQSEEHTRQAIKSEGTKTSRDMLVFCEKQAAVLASIKFRGSLMFAFERETGTSWFNPPENENRESSILPTTQHIRTEAQALLRELEEQRLPDLTAVFQSEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSD9</accession>
    <name>A0A1C1CSD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cholinephosphotransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CPT1</name>
        <name evidence="7" type="ORF">CLCR_08559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSD9"/>
    <dbReference type="STRING" id="86049.A0A1C1CSD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08559"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06672"/>
    <dbReference type="eggNOG" id="KOG2877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000029">
        <property type="entry name" value="CDP-alcohol phosphatidyltransferase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF77">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="443" mass="50182" checksum="4B40753D0447C29C" modified="2016-11-02" version="1">MAGSGRPQPDKHMSWKLPSNAHNVSIADPLSDEAMAYLKTYKYQSVDKSWISNHILRHYWNAAVKLLPMWLAPNMVTLLGFFCILFNILLVQIFVPDLVGPAPSWLCYSFAAGLWLYSTMDNIDGKQARRTGTSSGLGELFDHGIDSLNCTLGSLLETVAMGLGPTKIGAFTALVPCLPMFFSTWETYHTHTLFLGAFNGPTEGLILACSFMIISGYFGPEIWQHRAADYVGFDKYLGDMVFMDFWLPMVLGAFLFAHLPSCVINVYRARKQQNLPLWPVFLEWIPMIIYTASICAWCASPYSILLRENHLAIFCLTLSFVFGRLTTKIILHHLTRRPFPYFTVALVPLAIGGVMAWLPLFGFDPISAQHERWYIYGYFVFAMLQYFVWAVRVINRICDVLDINCLTIKKKAIDEREKQAFVGRELKTKSSANGEVRGSKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSE3</accession>
    <name>A0A1C1CSE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gcv2</name>
        <name evidence="11" type="ORF">CLCR_07954</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSE3"/>
    <dbReference type="STRING" id="86049.A0A1C1CSE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07954"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06666"/>
    <dbReference type="eggNOG" id="KOG2040">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="72"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="572"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="878"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT51416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1069" mass="117616" checksum="F8F2FDF99A89CA31" modified="2016-11-02" version="1">MASPSVMWPRAARSAHRVVHRQQLLRNELNRMCKRCMSTAAQQSEPTARRPPPTQVPQERPSFTETTERFSQRHIGSSPEDEAQMLKKLDPPVKDLDDFIHQSLPSGIRQKNPTIISRGKQNNTHGQKEGQVRSELQALGRRNRSWHNFIGSGYYGTVPPAVILRNVLENPAWYTSYTPYQAEISQGRLESLLNFQTLVTDLTGLTIANASILDEGTAASEAMTLSMNALSTARLKRPGKTFVVSNLCHPQTVAVLESRATGFGINIVVGDILDNDCQLVKDQGENLIGVLAQYPDTTGGVHDFQNLADVVHAAEATFCVATDLLALTLLKPPGEFGADVAFGSAQRFGVPMGFGGPHAAFFACSEKHKRKIPGRLVGVSKDRLGNRALRLALQTREQHIRREKATSNICTAQALLANMSAFYAIYHGPQGLKDIANKVWASTKFLQALIEKHSTTLKVVTKGLREDGAVLFDTVTLEVQDRDQYEEILSRAEAASVSLRTIISGDSGRKPQLAFSIDESTGLKSMSLLAQVLGIEQDVFDRALGESGILSRVNNTSNALQRSTPYLTHPVFNQNHSETELLRYIHHLQSKDLSLVHSMIPLGSCTMKLNGTTEMQPISNSAWNKHHPFAPSQGGYQALIARLSDNLASITGMHTVSLQPNSGAQGEFAGLRVIEKYHSSRGESKRKVCLIPVSAHGTNPASAAMAGMKVVPLKCDTKTGNLDVQDLKSKCEKHKDDLAAIMITYPSTFGVFEPAIREVCEIVHEHGGQVYMDGANLNAQIGLCNPGDIGADVCHLNLHKTFCIPHGGGGPGVGPIGVKEHLKPFLPTHPHVDPHPGPDRASTAISPVSSAPWGSALILPISYAYIQLMGSEGLKHGTEVALLNANYIMSRLRPHYKILYTNENGRCAHEFILDARGFKETADIEAIDIAKRLQDYGFHAPTMSWPVANTLMIEPTESESKEELDRFCDALIEIRKEIKAIEDGQMPREGNVLRMSPHPQHDLMRNDWDRPYTREQAAYPLPWLREKKFWPTVARVDDAYGDTNLFCTCTPVEGYEEEGFTGHQAPMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSF3</accession>
    <name>A0A1C1CSF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_08027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSF3"/>
    <dbReference type="STRING" id="86049.A0A1C1CSF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08027"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06648"/>
    <dbReference type="eggNOG" id="KOG1357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="182"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT51434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="806" mass="89194" checksum="505860B9EDCF6C3D" modified="2016-11-02" version="1">MEFRAKPTMIDSPKPQKTSDEPIIIRIQETQSISSEDTWSDTRLLHESESIYSSPACQSSSHRLQQCPLELDVYPPPYTKLWTKVAEGFRLAYTRGKVSLEQPRHSQQPISEAGRFNHCYVHPLDNRKRKNERITLGRWTPRLQVRDGHGTQHTVIQAASHNYAGFYGLTHDSEELQRLALESLPAANSYAMPFLEAAMHEGLAKFFSSEFCYTTSTGYGSNLLAFSALLNQDWLVMFDDKCHNSMHVAAFLSHAGLVKKFPHGNFRMMEAILSEHQGNFAKVLVAIEGFYSMDGTVPALDNLARLKKKYNFTLLADEAHSLMCLGRTGRGAIEVWNEQHSDALVSTDLFDLRTGTLSKSVGAIGGFVCGKAGFAPAVLRRRDEMLANGADPLPTSSILQTLHVLGQPTLLQRNLRRLTAIAIFVREALHRAGVHVYGNAVSPILPVYAGRPSMAARMSYSLRKVGLLATPVSAPAVPFWESRVRICLSADHDNDTVNDIVAAIVKAALNIGLIDKAPSLSKLFAYPVELSTRQETLEACEVAKQIRELIQQEILDTKPAMSDKGILRAGHEARLQYGLGSGGARWVTGTSELHVQVEKMAAKLIGTAEAMTYPDTYIGLMSTIAALSRPVLGFKKHLFLIPQEAPQAVLDGFRVASRKGSPKVESYTNVDALLEYIRGCGLSSYITLFLDVDGEETNLRPLLKRIQQARGSPGMTLLLHNHAGCTAGSFWQDEQALVRSSPGFRDHQFLMFGSFYRAFGLPGAYLAGRPVLLKELRYTSRGYMFTTSQQPFIMGMVAAELKKLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSR7</accession>
    <name>A0A1C1CSR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSR7"/>
    <dbReference type="STRING" id="86049.A0A1C1CSR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08419"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06543"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF103">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="493" mass="55781" checksum="B0A399A20A6DBF94" modified="2016-11-02" version="1">MLPVYLALLVSTALVVSFLRNHLFHPLRKFPGPFWAAHTDLWRVYHLWTRRMPDTLLKMHEKYGPVVRMAPNELSFQSVDIFSDVYKGGRKFPKSDFYQGFTTFHPNTFGMLDEELHAKRRRQMAHSFSVASLSQMESIYDAHIKNLLDAIDAKGSEPFNLKDLFGYYAFDIIGELVFHTDFGSQKAQDPAQLPPINEHIFLGCIFGMLPSLLPYSMRIANYLPIPWLQDLLNSRKRLKDRTSECLDREMSRQKTSEKQSILTRLIQAKDPETGEDLPKVAIASEAFAFLVAGSHTTSGTMTLLFYHLLRNEKIGEKLTKELEACIPLPDASDVSLPAYTGLEAQLPYAMASIRENFRITPVFTMPLPRTVTSPTGAVINGFQVPTGTNVSMCNYVVHHDPAVWGDDHHVFRPERWLDPSKPLSPNDLAPFGVGHRACIGRNVATMSIVKILAAVWRRYELELVDPNEELVVESVGIGEKQGPLMVRAKLRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTE1</accession>
    <name>A0A1C1CTE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metallo-beta-lactamase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_08716</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTE1"/>
    <dbReference type="STRING" id="86049.A0A1C1CTE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08716"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05228"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="61"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT51768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="387" mass="42926" checksum="4E65B1CD2789D817" modified="2016-11-02" version="1">MASDAQRKQEQSDALPAPGLNVPVSSHTCDIWAINTTCDIVCQSALLMGPENPGHENLNLPTFAFYIHNTRLNKRVLFDNGARKDWWNTTPQTYKGITLKGAVGIRVKENVYDILAAGGVDPDTIDAVVWSHFHRDHVGNIQLFPASTELVVGPGFQKSFVPGYPTVQEAAFYDADFHDRSLREITFDDSFKIGRFHAHDYFDDGSFYLLHTPGHTAGHLSGLVRTTPTTFVFLGGDICHFPAMFRPTPYGPMPSIIPEETKLDSRFPCPCPGSLFTASHPSADASEARISPYYHVPHQPGSWYEDPRQAQISVDGLKEFDAGGDVFIAIAHDPALKEIVEGFPTGKMNDWKAKGWDKQSRWHFVNELPIDGNPGRPLLVKGLLKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU25</accession>
    <name>A0A1C1CU25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase group protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU25"/>
    <dbReference type="STRING" id="86049.A0A1C1CU25"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08034"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06148"/>
    <dbReference type="eggNOG" id="ENOG502QUMF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="779" mass="85823" checksum="5ADC307E613CF2AF" modified="2016-11-02" version="1">MTRRKPKASTSTQPTSQPPDVAGDTNTSEQHPADPAPSPLPAPQKALNGKARPAPELSVSPTLIICRNKHTKHISSYSGPWLNLPPEVLDSLAHSNYYSPRPRPIDPAVFFDLVKIRRLIDDATSLAVRAANGTTSASLYTSQNATNGLFNGADAEILGIGSARGGGGHAKLSRERKHRMREHATQKLAHAYRLDEIASSVAMMQSASALEDVAKHVLQRDEQNADAQYVHFFHEKIPSMAVAEYTSLEPLTDVIRQNPTDPSPYRTRSVARMFKDDFEGVVRDSTDGLAVHRLYHSQHQNEQQDLVLARDAAGLGRDQRTEGRLEEKDHPNSLEPQLLFHRAGAYLTLACDNIRRALSGLRSGGTQHNGNGSGDSASALAEEALASFRADARRLVRTYAKRALRDYLAFLSHFDYTPGLSAEYTDAFLERVSSRPQGRGSRSEKLLDVEAAHAHAHAGLSEALVKYESQRNPQTKHNPLPQIPKPIIYRLNELFAAVPVANLPPYPSDRDMQVDQDHPIFSLPDFSEAVTYHPLLTDVLHSVLLCHCLIQTSSKELQRHAHMVARLVRVCDGYPIFLAARSPARADWVEILRRTKNWLGLSSTWDKLCTPTPFPGRKTAPKETAEDKKARIKQEALLEALADERVVDEESFRASFKARELRAARDEEEQARKDSNGTKLIEGGPTDQNGVQGEAPPADPKRWAQEDGGEYPITTERAEVLVEWILEAPPPSAVDGAGRAKKKTGAKGRPRKKASTASSLREATESGLEQGVDGLDLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU67</accession>
    <name>A0A1C1CU67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-3-methyladenine glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MAG1</name>
        <name evidence="6" type="ORF">CLCR_08567</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU67"/>
    <dbReference type="STRING" id="86049.A0A1C1CU67"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08567"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06082"/>
    <dbReference type="eggNOG" id="KOG1918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="218"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT52051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="399" mass="43613" checksum="BC12FBF473C17F74" modified="2016-11-02" version="1">MAYIVTFGDRQQVVVETAVDQVNASKKRPASTQARSTQAKKQRAVEDKGQKGVEVSEPMNLLVNGESKEEPEFKVPVTPAKKTARRSTPSKAKHPPLTPTPSFVNVIRAPYSSGDIDDTTPPPDRPVGPHITNAPLITPGGTQHVAYEDTLPDSTPSKTGLPRPTATANTVLDQACAHLISVDPRFEAIIAQHPCHIFSAKGLAEIIDPFRSLSSGIMGQQVSGAAAKSIKNKFIALFNEGQDPEDAKFPTPAQVAATDIGRLRLAGLSQRKAEYIQGLAQKFVSEELTNEMLMKASDEEVMEKLIAVRGLGKWSVEMFACFGLKRLDILSTGDLGVQRGMAAFFGKDVKKLKAKGGGKWKYMSEQDMLEKSAPYAPYRSLFMWYMWRVEDVDVEVLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUC2</accession>
    <name>A0A1C1CUC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUC2"/>
    <dbReference type="STRING" id="86049.A0A1C1CUC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08269"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06032"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="57"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="61"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="139"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="295"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT52111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="551" mass="62366" checksum="9843B6925DA6D686" modified="2016-11-02" version="1">MEQIGQASPSSEGDSNAPTLAGPTSRTPSHGLRVYPLTGYLHNDEEKDGPWAGKIILSLDGGGIRGYSSLLIVEDLMSKIAALEQDTSWIDENIKATYQLYDEDVKNVRCSADYPWKGQNITVRDERFYPAHYFDYMAGTSTGGWAPSDLLNCSEPQADASQAQRNNEAKEQYTRFGDNVFGQSRWFHMRSVLWYPRPKYAAIKVRQTILEVVRLGLRDPSIVDYEVQRETLAMDPRRVGGGTEGPFVHRSFLNESSPYNRGSASKMPIWQAAMATTAAPVFFERQHDGNDAYIDGGLGFNNPAKIAYKDVSDRHALPPKIVISIGTGEKASRPVMPRRNQLGDIMGSSDDRRQRLKKLVELVFKHSKNWLTDVDEVVDDMGFMANMFKFKFTRLSVPNDIRPGGHCLGEIPLDDWRPKDGGRTTLERLENLTNTYLAQAETRGMLEECARELVLLRRQRARTERWETYAMDVTYRCCADENCHPGPYLKNRRSMRRHFDEKHGELTRDKSPREMENILNTCRVVKDETGGARDGSASRRPPRQGTNGIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUR7</accession>
    <name>A0A1C1CUR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUR7"/>
    <dbReference type="STRING" id="86049.A0A1C1CUR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09312"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="108" mass="12244" checksum="633C8E1BD7CF598A" modified="2016-11-02" version="1">MMTYLTSDAAESYNDRVILRRMREQAEKELLQRIRARDPSSPVEQPDAYYDCMVGQEAIRQANWACANMASGKVCLFGGPVALMIEKHESLLREGCWMPALGLGHMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUT0</accession>
    <name>A0A1C1CUT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_08923</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUT0"/>
    <dbReference type="STRING" id="86049.A0A1C1CUT0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08923"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05902"/>
    <dbReference type="eggNOG" id="ENOG502SQ3I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651063" description="Cytochrome b561 domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="10">
        <location>
            <begin position="57"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT52261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="279" mass="30846" checksum="3B8C21F7EC354E1C" modified="2016-11-02" version="1">MKSQLFSAMLFAASAATAAAATILSDADHLQQEPHAALQKRAFYQDDFKIYKRKRNAHACIMSIVFIVLFPLGAISMHLPLRGVRVTTRIHAPIQILGLAMMIGAMGLGIDIADVDLNFFARDTSTKAHVVIGLLTCSVLILFQPALGLLQHLHFRRTGKKSIFAYIHRWSGRVAICLGWINSGLGFQLVPISLVSTGSLVRNFVLMGVLGAVWFLLVGWDGYRHHWAKKDKLGAYRVGWDKGVVLRRQHAVEDGTKDDMKLEPRHSGDQGTTAGEQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV88</accession>
    <name>A0A1C1CV88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV88"/>
    <dbReference type="STRING" id="86049.A0A1C1CV88"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10783"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03807"/>
    <dbReference type="OrthoDB" id="4160303at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651064" evidence="2">
        <location>
            <begin position="22"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="229" mass="25755" checksum="723F75CFCC2B3BE6" modified="2016-11-02" version="1">MSIGTLLFFSLLMLLWRKYHPRTFHKVVDSIPFFGCFGRWRKTREKNKQVRRMRSLGILTGENAGMSGSVTGAIDTYARHLKKFEDDAARAREKMSFETPTRTPASPYTPGRKSRRSNSITALPKIGSPWKSPKPSTPSNESHDAIPLNSSPMRNGARAYGPFKRTYPDETDSLQSWEEKWYALGSEHGTPSSTTKPTIVGSKIEGHGMQSKDEFEAESGPGQSWRKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWI5</accession>
    <name>A0A1C1CWI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long chain acyl-CoA synthetase 7, peroxisomal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LACS7</name>
        <name evidence="4" type="ORF">CLCR_09719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWI5"/>
    <dbReference type="STRING" id="86049.A0A1C1CWI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09719"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04144"/>
    <dbReference type="eggNOG" id="KOG1256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031957">
        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015916">
        <property type="term" value="P:fatty-acyl-CoA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="67"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="710" mass="78322" checksum="23B02D8144623E2C" modified="2016-11-02" version="1">MPLLSSKPLYLQTASEYFQAPPKGQPYSITLPGSEQPNRTPVYRHHKCRDGLLETLDPSITTAHEMFEFAAQRFPHAPCLGFRPYDSAKQAFGPYEWLDYETVRKRRSDLGAGLVELHAREGIHGSNYGVGLWCQNRPEWQLTDLACMSQSLYSVSLYETLGPDTSEYIIQHADLASVVCSLPHVPTLIRLKARLPNLKFLVVLDPLEPGQNERPELSKQVLLDNMAADVGLKIYSLDTVEKLGASLGKPNKPPKPSDAITINYTSGTTGPPKGVLLTHAMCVAATSASLASNDLVENGVAISYMPLAHIYGRLLEHSAIWAGFRIGYFHGNILELVDDIKLVRPTMFASVPRLLNRFGGAIKANTVEQPGVKGALGRHVVRAKMARLNPPAKSNATPTYSHALYDRIWSRKVASALGLDRATSVVSGSAPLDPSLQQFLRVALSTRVFQGYGLTETYAIALAQPGNDLSVGNCGAIVPCSEACLVSVPDMEYTVEDKPHARGELLLRGTCVFTGYYKNPEETAKAFTEDGWFRTGDICSVDEMGRFRIIDRRKNVLKLAQGEYISPERIEGVYLSSCTYLAQGFVHGDSSQTSLVAIFGIQPDVFAPFASRILSRPISATDIPALKAACDDPQIKEAVQKDLDKCGRKMKFAGYERVRSFKLMIDPFTIENELLTPTLKLKRPNAAKKYRSILDELYEAEAQRPRKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWJ7</accession>
    <name>A0A1C1CWJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exosome complex component rrp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rrp4</name>
        <name evidence="9" type="ORF">CLCR_10407</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWJ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CWJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10407"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04263"/>
    <dbReference type="eggNOG" id="KOG3013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="108"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT52922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="349" mass="37671" checksum="DEA3359D6164738C" modified="2016-11-02" version="1">MGLAVLPPDSEDENVPVQVSGDEEDSDASMQDADEGRPSKRRRLASSSRQIALPGEVITDDTQWMRGHGTYMTEGSPTMIATLAGPLKKTNKLLSVAPLRARYTPEIGDLVVGRIVEVQKNQWKVDVAAPLLALLPLSSINLPGGVLRRRTTADELQIRNYFQEGDLLIAEVQQLRSSDGTANLHTRSLKYGKLRNGTFLAVSGTGGGGGVVRSRRQVFTINGGAQGGGDVDVILGVNGYIWLSKHVEQAQDQSRMSGGVSISNLDDVVSSAIYSSQNDDIGEGTRREIARISECIKVLAEEGVRVDEDNVIKAYEAAVDAEMGVMEQDGVPTCFSDEVRRRIVDAALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWL4</accession>
    <name>A0A1C1CWL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Low molecular weight phosphotyrosine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">stp1</name>
        <name evidence="6" type="ORF">CLCR_10962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWL4"/>
    <dbReference type="STRING" id="86049.A0A1C1CWL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10962"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04163"/>
    <dbReference type="eggNOG" id="KOG3217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="5">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT52818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="147" mass="16662" checksum="74E0AFF2D0C31099" modified="2016-11-02" version="1">MAEGVFRSLTKSNPRVGEVDSAGTGAYHTLDPPDYRTVKTLRKHGITDYEHGARQVHAGDFEKFDYIFAMDAYNFSDLQRLQRRAESKGKKTKAKVMMFGDFGGKSKGEEVIDPYYGADNGFEEVFQQVTRFSKNFLAEVVNKDTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX26</accession>
    <name>A0A1C1CX26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10890"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04282"/>
    <dbReference type="eggNOG" id="ENOG502S8NN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5424462at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF2">
        <property type="entry name" value="DUF3602 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="177" mass="18536" checksum="244544371202C5E4" modified="2016-11-02" version="1">MSTRSYSIVEPHPNPSPSAHYISTGRGGAGNAIRTRGADATAPAAAAAIRASLATSKTSPSSMSTHSSTHRQWSTGGRGGAGNVFPASERAIFSFDEELERQLRRERDVAPVYHVGRGGAGNLMFGASGSERKVERRMSDDSGASLASTSSRGSESGADTFNRSVKKGWKKIITGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXF8</accession>
    <name>A0A1C1CXF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_09944</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXF8"/>
    <dbReference type="STRING" id="86049.A0A1C1CXF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09944"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00143"/>
    <dbReference type="eggNOG" id="ENOG502SQWM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF3">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651120" description="Cytochrome b561 domain-containing protein" evidence="9">
        <location>
            <begin position="26"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="10">
        <location>
            <begin position="295"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="270"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="488"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT53175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="557" mass="61209" checksum="E889163BC5679207" modified="2016-11-02" version="1">MWPFSTRLPAVLAVLVTTCTILANAYRPVQFVKHTGQSGRADQAFSLVNYYNTTTAQSDLYVRMWMFRYDSSNKGWASLGLGPQMKGALMFIIYGDPASNDLTMTVRTVDGHHPPRPLDEMKDFYSGEVPDVEVVSTRFEAYTGDWYSEQLKAKPSHLGVAEFIVRGYEKFTAPALGIHSDSPKQSMIWSSNFKQDFEGDFSHERSIDMHQFGLGFGFLWVDLLNAKSEVPFFQTIDEVSDHSGLSEIGDPAVPSDEELKKGDEIIAAQLSGGTGEGSADATTPGDKEASPQPPTADADTSTPGADDGSKVEEPVKTVKQWNIRSFMWHLHGLLLTLAFLVGYPLAIYLLRSPRTAAAGTAFNYHWTINALSSVSVSIGAIIGFMNSRSISIFHQYLGILIVCALAAQTVLGWRHHVVFVATGGRKTWMSAVHVWLGRAVLPVGMVNVVLGLMLRRYGWLTISLCVALAAVEVVVLTLVVGQARNRRPGAMQKGASAPPADEAEEYFQLTGNDDDEDDDDDAFSDDEERAGLSAEARAKKEAQREEQRKKLAKLDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXH7</accession>
    <name>A0A1C1CXH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10682"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="245" mass="26411" checksum="2D8B40CD6F7B13C3" modified="2016-11-02" version="1">MNFPNDYEVKAAMMPRTSTYPVRPAARPPQETERRLFPSSDDACDCCLYCILMCLTCCFAGDLAKRKKVDRAGPRRSSAFLYTRGGVRPQLPPQALHAVPRMRQMSRPRIPYHPPRMEYPVSGFQGGGFDMADGADEMEEMEEMEQVEHTEHVEYEALGGSPGAEAEEGAEGGEEGEVELEVDGGAAGGEDNGEEVEAEYEAQEEGGGGDDGGGEPEAEQERQAGGGGEDDRGGGHEAEADVNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXJ7</accession>
    <name>A0A1C1CXJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nuclear membrane fusion protein Kar5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_09751</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for nuclear membrane fusion during karyogamy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the KAR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXJ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CXJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09751"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00162"/>
    <dbReference type="eggNOG" id="ENOG502QVCQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5311848at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048288">
        <property type="term" value="P:nuclear membrane fusion involved in karyogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007292">
        <property type="entry name" value="Nuclear_fusion_Kar5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012:SF1">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0415">Karyogamy</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT53196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="69064" checksum="897D378D1810C3B4" modified="2016-11-02" version="1">MLWSGDSLVPSNLRRLVLASVVALIGHAHARFLRADLKWPVFWKPHNELQPSLTDVLTFREPDSDPVFEKAMHMVNTLSTQSTCHQAAAVQLLVTCKTVGASMAREDGKHELLERAKSVYAVRVAVCETGEGRAEVPSACKPILTIPQRLNHEIDVVSSRTVAPCLGALMEEHYYWTSYSNNKQDANTLCQASTLESTRLEALQSYQKLAELLPEFRIALRSTRSQWMDFLTQQKEEVQHVNMLQRQNRDELQAQHKVELGSFRDSMRMAKDGLLDISQSLHQAIVGTGSDITQAREALRDVLADFAGLKILLQDTAAETSENNAELVAAQTRDIANVHDLALSAARALENVHVEAFAQDVHALVHQINTNLDQIAGAQYTQLGTMLQYLELSKELSSAQEANLALGERIKDSSASLASELDTANAAAGQVSNKLDRVNKALAHIEAATASLSSLFGIIAIPRQMVGRLHLKLLAMFATPALILLFWKPMKYSCTVMATYIFLETMISLVHEHRDIVSTYLGRLIHHSRAITHSGSIALRDNVALAVAAIIIVFCCYCLVSKRTRPKQKPKPKSIQSLTINSIQRLDELTTSEWGHDIYRLRDGRRQWRSADKFPRAATVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYJ0</accession>
    <name>A0A1C1CYJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alternative oxidase</fullName>
            <ecNumber evidence="17">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">aox1</name>
        <name evidence="20" type="ORF">CLCR_10384</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16 17">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the alternative oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="17"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYJ0"/>
    <dbReference type="STRING" id="86049.A0A1C1CYJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10384"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00487"/>
    <dbReference type="eggNOG" id="ENOG502QSB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005229">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="304"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005229-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCT53521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="344" mass="39472" checksum="45426A580E1D6558" modified="2016-11-02" version="1">MTSTKALFTPTLTANLSRAASKGLLCSTATSTGLRASYAAIRPLDAQSRRHFSASGRAQLDFFPPPKNLPHIKLTPPAWPHPDATEEQLKSIEIAHREPRGLSDRVAFNTVRFLRWCTDLATGYRHDPDKPYVMNERKWLTRFIFLETVAGVPGMVAGMLRHLRSLRSMKRDNGWIETMLEDAYNERMHLLTFLRMAEPGFFMRLMILGAQGVFCNGFFVAYLLSPKTCHRFVGYLEEEATKTYTFAIEDLEAGKLPKWQNLEAPEIAVKYWNMPEGHRSMRDLLYYIRADEAKHREIHHTLGNLNQAEDPNPFASEYKDPSKPHPSRGIEHLRSKGWEREEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYL3</accession>
    <name>A0A1C1CYL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-2,3-butanediol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">budC</name>
        <name evidence="4" type="ORF">CLCR_10633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYL3"/>
    <dbReference type="STRING" id="86049.A0A1C1CYL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10633"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00527"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF121">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="269" mass="28626" checksum="B83CDE8EA01F722F" modified="2016-11-02" version="1">MAKRTAIVTGSSRGIGESIVRRLAQEGYKVTVNDVSANKAGIDKLVSELNSTHGQGTAIGVVADVTSSSDVQNLIKESVEKLGPLTVMVANAGIAQVAPALDISDDDVHKMFEVNFFGVWLCYTHAARQMIKQGPVEEGSSGYKILGCASIVAFKPFPLLSHYSASKWAVRGLTQVFAMEVAKHKINVNAYAPGIVGTAMWDLIDEKLGEIEGRPRGETVKKYSSELTALGRISVPDDVGNVVGGFMCSKDAEFVTGQTMVIDGGIVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ25</accession>
    <name>A0A1C1CZ25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Charged multivesicular body protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CHMP5</name>
        <name evidence="5" type="ORF">CLCR_10915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ25"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ25"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10915"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00650"/>
    <dbReference type="eggNOG" id="KOG1655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="167" mass="18824" checksum="7015A5BA834A4CC9" modified="2016-11-02" version="1">MREGPGKQAIKQKALKVLQQRKMYENQRAQLQQQSWNMEQAGMMQDNLKNVMTTVDAMKTTNKALKQQYGKINIDKIEQMQDEMADLMEIGNEINESISRAYDVPEDVDEAELDAELEALGEDMMFEQEMGIGESTPGFLQDEVAPPQFVDEPPEHTKVKEAAGGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZB1</accession>
    <name>A0A1C1CZB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_09644</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZB1"/>
    <dbReference type="STRING" id="86049.A0A1C1CZB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09644"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00785"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="649"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="276"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="714"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="720"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="742"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="780" mass="83810" checksum="91F2C07E4EB1E110" modified="2016-11-02" version="1">MEDDGASNGFLRPLSQPALNSRFPSLRRLNSTEPYRHRSLPAEPSPGSDRASSEITFAVLYDDGPDYHVGRYDDQGSMRSHQQRDSIQSYAPSFRTRDSRIVSDDHYLGRDQDFVANQRLLAEGYLNSNDSLYDQSVPRYPTQSEETLAMNTLHNTYPRDEKRPLSQQMTPPMDRATSKHSHESWCTCEEDHGHGHGHGMLDRKDPAKFDLEAQNGPATPTPFLPKEKPGGGPGGPGGPGGPGGPKKPKDPFDVTFEGPNDPLNPKNWPSKKKWAITMLTASFTFLSPLASSMIAPALFQIQEDFDIKSDFELQMTLSIFVLAYAIGPMILGPLSELYGRVVILQSSNVLFLAFNTACGFAQSSSQLLAFRFLAGLGGSAPLAIGGGVLGDLFKPEERGKAMGIYAMGPLLGPAIGPIVGAWVAEKSTWRWMFYASSIVNAFILAAGFWKLNETYAPYILHKKAKMIRKQTGDNRYRADGEGEVDQPVWKKIVKTMVRSFGMLFSQPIVQVLALYMAFSYGILYLALSTFPNLYMKVYGESVGIAGLNYISLGLGFFIGAPLCGKSGDKVYRKLKAKDPRGLGKPEYRMPVVIPFSLFVPIGLLVYGWSAQVKTHWIVPNIGSFLFGIGTIAAFQCVTTYLVDTYARFAASAVAAVTILRSLAGFSFPLFAPIMYKALDFGWGNTVLALAAVGIGIPVPILLWLFGEKLRKRSSLASKGPPGGRGPGGPGGPGGPGGPPGGGPGGPGGPGGPGMKGPGGPPGGPGGKGPAPSGKPPGYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZK6</accession>
    <name>A0A1C1CZK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10382"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00855"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4127210at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="380" mass="42310" checksum="AE3287A66917BC20" modified="2016-11-02" version="1">MLTAKQNYGPGTKQPFGKRVFFALPFLVLSFLAHRIFSYILAQPAFHSTVTKSLALGQLEFNGQVWKLPTQLSPFALLVTAFSPSTLDIDPVQKLQAVSFIVDLSPLWLIYILEAHRRANEFKITFTLPLLYGVAFKLRGIGIVGPIWFFAHYVQSPIADYAAKDWRLVNVAAAKTAGVAVFLAFTMPTLAMYYLPNPTHRLVVNAIWQAFPVLSILLHYVLRKTIVKDTTRHDRIYHVEADMPYIRIAVWSFASISALVFNAARYTSSTSLTTIYFPDRILLKSAISSGDGTLDLISGMRLFLQVDEIVCFGAAFLWLAYLIGDLKEAEMTSVSWAKVVALAAAGTYLIGPGAVILLSWWWRENILATKHAKGSVGPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D025</accession>
    <name>A0A1C1D025_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_10188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D025"/>
    <dbReference type="STRING" id="86049.A0A1C1D025"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10188"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00981"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04733">
        <property type="entry name" value="OYE_like_2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF5">
        <property type="entry name" value="NADH:FLAVIN OXIDOREDUCTASE_NADH OXIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="16"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT54082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="447" mass="49209" checksum="95FC94D50A0098CE" modified="2016-11-02" version="1">MPDRWPSDIKDAGPLAQPLKFEFSGKTAPNRFLKAAMTERLSSWDPEHKEKRGIPSEQLIRVYQRWGEGGFGVILTGNTMIDYDNLEAPGNPIIPGDTPFEGQRFEAFKELAKEAKAHGSLVVSQVSHAGRQVDQRLQPDPVSASDVQLEGDVMGMRFAEPHAASHGEIQDIIARFTHAAEFLHKAGYDGIQLHGAHGYLLAQFLSQTTNKRTDQYGGSLHNRARIILEIAQSIRQKLPSSSGFILGIKINSVEFQEGGFTADEAKELCILLEKHEFDFVELSGGTYQSLAFVHKRESTKKREAFFIEFADQIVGDLRKTKTYITGGFLTLDGMVNALKTVDGVGLARPVCQEFHLTKDLLEGKVSGAIEQKIDRDNFGLTNVIAGSQIRQVGKDQEPIDMSVPENVDAFMKDMGTWGEKMKSGGASAYGYVDIESAKTSQYGAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0D9</accession>
    <name>A0A1C1D0D9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0D9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00308"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09453"/>
    <dbReference type="OrthoDB" id="4161165at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="327" mass="33864" checksum="88A256F9287D3DD2" modified="2016-11-02" version="1">MKSLYCLVPLGMSATAHGAEHDDVSYSPPINHITITSFPMPSPDPAMIRSITAVQPLLANMTVTALEGFQSPIPTLLKQGGLCQGGMAFCDGLWNCCPGGTYCTVDSQGAGACCANGAACTGLSTPIPAQAWSNTGVESTPRPRRIFGFLARLARSSSWYTADNSAAADLAATYEPDAPKVEGKNEGGGGGKGHGEVAVADPAPKLNLTSAKATFAQNAMSWGAPMPRPSSLPDVSVAPVGFARQIRPAIVPSKTPTSRSAPKLKFIGANPATIKSQQNQTSSGAGVSRPLSVFKFPVIFANNIKAAFLPPSEAAETRVQNCLPCQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0Q4</accession>
    <name>A0A1C1D0Q4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0Q4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01007"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="95" mass="9862" checksum="3847951BC289BE82" modified="2016-11-02" version="1">MASESGHKGRFEEDQTGEIKVRGTLVGRMRPNSSFSSGGGMWCGARQAAQQELSFASGSNAEDRHGLAGVGLLSQDMQSGGGRKVNCATQCRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0Y0</accession>
    <name>A0A1C1D0Y0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GTP-binding protein ypt5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ypt5</name>
        <name evidence="12" type="ORF">CLCR_00925</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0Y0"/>
    <dbReference type="STRING" id="86049.A0A1C1D0Y0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00925"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01598"/>
    <dbReference type="eggNOG" id="KOG0092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000464">
        <property type="entry name" value="GTP-binding protein ypt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT54320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="219" mass="23868" checksum="8644A58746E33773" modified="2016-11-02" version="1">MAARAPVGRPGAGGRFAQFKLVLLGESAVGKSSLVLRFVKDQFDDYRESTIGAAFLTQTISLDENTTVKFEIWDTAGQERYKSLAPMYYRNANCAVVVYDITQASSLDKAKSWVKELQRQANENIIIALAGNKVDVVNEYPDKRAIQTADAEAYAKEAGLLFFETSAKTSTNVKELFTAIAKKLPLDQAGPRNLRANPRPGVDLRPEATQAGAAGNCQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0Z0</accession>
    <name>A0A1C1D0Z0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_00816</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0Z0"/>
    <dbReference type="STRING" id="86049.A0A1C1D0Z0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00816"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10135"/>
    <dbReference type="eggNOG" id="ENOG502S731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF13">
        <property type="entry name" value="MFS GENERAL SUBSTRATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="429"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="606" mass="65415" checksum="1C22AFA5862EE125" modified="2016-11-02" version="1">MGSHNHNGRRRSSTQQRAGDEDGTAPLLLSRTRSLEDISVAESVAVQEIAPEGDDRPDAPAGRWPRSVPYLLLLCAFLTSLSFGVTQVPLLYVFRLMTCDAYYKDHPSRVLEDAQHSQPGTITSMLFHALVASSPVSGLEASGTPDRCSIRPIESSTAMSVSLLGASTTVFGTANLFLTGSLIKRIGVKPTLMTQILFPAVRLVVQNVGVGVWGSTGIIIIQLSQIFTVIGGPSGYLLALNTFITEVVDYEERTAALGRLSGSMFFGSAVGFLLGGVAGESFGIKAPFRLTLVLFLLVCVYVFIFLPHIPPAERIEDGADSTKTKKSTSAMGKFFGPLTVFAPRKFITKDGVVRREYGAFLLAWGVYLGILATGYLVTLLQLYATNVFDFGTKQNGALIFMYSMLRGVFLTFAFPRLIAFGRRVTSNRKKRQEVATPPEREPLLSASQNDSTSNNRDEEPPQERTFAFDLTYTKFSLIADGLLTLLCSFVREGWQMYVVAAVLPFAAGTGSAAKGTVLQMVGSSATSSERTDALAGVSLVENIARLSTTSIFGLLFAAFASIGRTELVFVCNAAVALIGFVVLLFARFPPEGSRRLDQKDVSTPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D197</accession>
    <name>A0A1C1D197_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_00772</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D197"/>
    <dbReference type="STRING" id="86049.A0A1C1D197"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00772"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01692"/>
    <dbReference type="eggNOG" id="KOG2419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="UniPathway" id="UPA00558"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF11">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="531"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT54430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="752" mass="84067" checksum="7A2BE59D133BCA6B" modified="2016-11-02" version="1">MGAVLSYVHSILDNALATVKLVQNREVGWKTLNRKTGRYERERQPIYKKIKLWLLFSWPMEWIDRTWLLRHWIHDKTIRSGKKEGTLASASQIQSFVDFYHINMDDFSPSDIHAYRTFEDFFVRQHKPGARPIFEEDDPSRAVVVADCRLVVYPTVAESKRLWIKGRNFTIGNLIEDDATARTWHNGAIASFRLSPQDYHRYHSPVEGVVEWFKQIPGEYYQVDPLCLRSDIDILTLNARCAICINSPLFGRVLFVAIGATNVGTVEINQKCRTKGSHLRKGEEVGLFQFGGSSIIVAFEEGRIRFDEDLLSTYTAVSVFRLGDASSLDAASPARQSAPIMTLPKPNASFKIPSVHDDTELDCRIYYPRKTEKNSRAFGRSFAIVAHPYAPLGGCYDDPVVALVGGVLLQQGFVVATFNFRGAAGSSGRTSWSGKPELSDYVSVYGFLLHYINAIIRAGAEEQRYRYEPPLLVLGGYSYGSMIASHLPPRDVVVELFKSETPDSAGTEIKRRAEELSRDARAYFDRYSASTTLAVPGSPGTPRGQIRKTKPGVIMGGYESGRIRRENSRKSIDTERIRQSLDRVRRKIGSQPDSPSPPTSSSAPVTEPATSPHAEPAPIVLPDVAYLIVSPILSMAASFTTMFSKLRFVAKGLQGASASEGEFHQGEFHQLTVHPCCCLYGNKDGFTSARKLQRWTEELKARPGSRFMAVEADAGHFWREADGIVRLKQGLCEFLETLTTRRAASTVDDARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1A1</accession>
    <name>A0A1C1D1A1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BNA2</name>
        <name evidence="6" type="ORF">CLCR_00880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1A1"/>
    <dbReference type="STRING" id="86049.A0A1C1D1A1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00880"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01703"/>
    <dbReference type="eggNOG" id="ENOG502QV6W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT54440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="397" mass="43974" checksum="F49745C0E17D2802" modified="2016-11-02" version="1">MLFRPSLPSPQDYDVDLGTGFVTASPAELPAYYAPWCKLISDLPCLLESATFQTKVDELELLSTSHLIAPAHWQRAYVVLGFLTQAYIWQDKTNPSEIVPTNLGEPFLQVCEYLGMKPVLSYAGICLWNWTPLPEGGRVDTAQALSDFQSITSFASFTGTRDEDAFNLVPVIIEAQGAKLVPAMLKAILDDRKGVSQDLSSIFDICATTLSKMGDLLAVLHKNCDPTFFYQRIRPMLGGSAGAEERGLPNGVTLRRSNGLHETVKCVGGSAAQSTFFQFLDHMLGIRHESKMLVEMRAYMPKKHRDFLEAVELLPSLRDVIDRHPEDPGLQAAFQPVIEAFQRFRTKHVAVVSRYVSLPAAAQLQGKPAIESRGTAGSLPIPFLKQYRDETTFKPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1N6</accession>
    <name>A0A1C1D1N6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CorA family metal ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_02760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1N6"/>
    <dbReference type="STRING" id="86049.A0A1C1D1N6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02760"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04698"/>
    <dbReference type="eggNOG" id="ENOG502QPTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000014">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="808"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="843"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="449"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="871" mass="96886" checksum="7CE2B59B2A734156" modified="2016-11-02" version="1">MQPLPPPKRGQSSQPIGARDQTRPGMNSSATAPTAGSAAAGAGRLSTVSTAAADGKKKRKHRAGKKRRNRRQSFAAPSETSAMASGRDGPTDDPLIEEPQPPSIRQSLYRSSNRNLSNESLDSGALLDHRDQPTLRPRRDSRLTPLFATSYRNNHFPKAESSTRSRQRGQQDTSSRGGSDSEDANDKTPLISGAQQHKSPEQTGFGLFRVKSNTSTMSAGSKQPRRQRTIGTPGHSVPKSDASYDVNNPPSVPGSPTLGALYEDVMVDEVNFLNRSPDSRRNLAGGNKDVLIDIDGDVDDEPNSAPPSPRLRPGGLQRHRSTTMNAEADVCFPAEDASEIGDPFDRSQSQGHFASGQRRRRRQREDWPKLWVLDEWAREEKEARAAGERRAKKISEPVFVEGRLRPRKSAWHRVEEDKQYRFTYFNEDFGSTIHAETISELVQPDGSFRELFIPDPPEIADSSESEDDDVLDMTSALQSPKSTTAIEKESGLPSLAGSLKPGASGKSSDRSKNSGSATPQNRHSSMQAPKPKKYGPRPTFWLDVLCPTETEMRVLGKAFGIHALTTEDVLMQEAREKVELFRNYYFINYRTFEQDPHSEDYLEPINMYVCVFGYGIITFHFSPIPHPANVRRRIRQLSDYLVLSADWISYAIIDDITDVYGPLITHIEQEVDAIDDLILRAFQHTAALSGEYGEKGINEKSTDEGDSGVSGIDMLIRIGECRKKVMSMYRLLGNKADVIKGFAKRCNEQWEVAPKSEIGLYLGDIQDHILTMTGNLSHYETLLSRAHGNYLAQVSIHMNERQEKTADVLGKLTVLGTIVLPMNIVTGMFGGNFKVPGQDVDNLWWFWGTTAGLLVFGVICFWWCKKVYKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D203</accession>
    <name>A0A1C1D203_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor like protein RFX-Penicillium chrysogenum</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RFX</name>
        <name evidence="4" type="ORF">CLCR_02799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D203"/>
    <dbReference type="STRING" id="86049.A0A1C1D203"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02799"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04815"/>
    <dbReference type="eggNOG" id="KOG3712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000119">
        <property type="entry name" value="DNA damage and replication checkpoint protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT54715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="719" mass="80491" checksum="D669937BB1C40499" modified="2016-11-02" version="1">MPATWIITHIPRLQESCQRSANSVRRDRVFTRYTERCGNERVPTLNPASFGKLVRIIFPNVQTRRLGVRGESKYHYVDLSLVMDDDDRPYAPPIERPGTSSGNQDERRASNVDATKVFKSHISPSLDRPMSRATMETADFPAPSAAFLSKEADTAAEDVPSAQDAPSQRLDCKYIDTPTIRFPVKTMPGNVVAALPSIRRHLPGSMASYLGMPTPNSLSLPATSSRDTPIDFPDIHPYLEGEIYDAAIARALFHLYRSYCIDVIDAFRKCKEKPFFSHHSAFNGKMTVPVSKVFSMPCLAPWIQECDMRMYKQIVRFIAPLALQNVPDVVWNVFDRIGTKLVGHLISAFEEKCPVHVIVAKIVPAQRFVNVLKKLKGANTATLQFSRMLEDPQQRTQMWLDLMSIVDPDQLLEDSMPAPESIEKVRGMLKHDMRPLVDPVDEPLVHAAEDDPTSAYATLLNDDSVATVGILLPEVSDDPMSLLERWVNWLERLPQLYGGHHPQCMINWHTRLWKSIMTQMGRGVAHSYQSWWFVESFTTQMLDWMTQMEGLMLDSRSQTIADEREQDKCRQALSLPDEPFRGTKRKRTEGEAGFSPSAQMEQDSHASKRPVTAPKSSPTLPSTRVMDDAAPAIDDDATDADLDELRHGGPLDLPSFHTGLTSPVKGRGPGNHDDSGIGLGLDVEVDVDAEKEARRFNKKDWFLSSDPADSGIALGVMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D225</accession>
    <name>A0A1C1D225_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D225"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03214"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="71" mass="7623" checksum="74D84F94631BE9B0" modified="2016-11-02" version="1">MPVELLLHEETLDMSYEPFEGQDEEVLSRASAPVSLHAPTSKIHILFGSDVFAAAVEESAGKNSPVDQLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D227</accession>
    <name>A0A1C1D227_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D227"/>
    <dbReference type="STRING" id="86049.A0A1C1D227"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03008"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04805"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="100"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="342" mass="37761" checksum="35BEF1838723E44E" modified="2016-11-02" version="1">MDFHNVLKLDPSVFDPAAISEETKAFNHKLMDIMSHGPKWYEVGAKRYREMRAAGETPLPKATYLDTAEDFNIPSRDPSRSIPCRILRPQNGKSTKAVFLHIHGGGWVLQDQKSQDPALQDIANGTGALCFSVGYRLAPEDPFPAGPEDCYDAAEWLVDNAEAKFGVPLAFVGGESAGGHLSMLVALHLLQHSNPKYASFAFQGLLLHFGCYSMIWTPQVYNFQRSPPLVLDRDLMDHYIDVFLPGKSDTEKRHPAISPLFTDLEPLRGRLPPALFTCGTDDCLLDDTMFMSVKWLMAGGEAVVKIIPGAPHGYIMFPRSMKGSGAAEGMKAVEDFMLSKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D240</accession>
    <name>A0A1C1D240_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Probable beta-glucosidase E</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Beta-D-glucoside glucohydrolase E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Cellobiase E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Gentiobiase E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">bglE</name>
        <name evidence="24" type="ORF">CLCR_02745</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D240"/>
    <dbReference type="STRING" id="86049.A0A1C1D240"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02745"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04949"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF20">
        <property type="entry name" value="BETA-GLUCOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="23">
        <location>
            <begin position="870"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="769"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="824"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00041811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="OCT54857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="957" mass="102992" checksum="030CE3A163D92BB2" modified="2016-11-02" version="1">MPSQQARYQPLQSPADEGDFSDDNVAASTLGTQEPLALRSGPVAGAAASSSEVALLRPSASTKRDYSDAVASRAFVSQRLTKSHIAFSVLVLAVFVSLIGGGGYWVYNKGLINGQSPPWYPTPRGGTLPSWQNSYEKAAKLVGRMSLVEKVNITTGTGWAMDLCVGNTAPAVDVGFPGLCLQDGPLGIRFADHATSFPAGITVGATWNRELMRKRGAAHARQARLKGVNVLLGPAMGPLGRNPAGGRVWEGFGSDPVLQGVAAYETIQGIQSQGIIATAKHFVGNEQEHFRRPLEWGLPEALSSNIDDRTLHEIYAWPFAESVRAGVASVMCSYQMVNNSYACQNSKLMNGILKDELGFQGFVQSDWLAQRSGVASALAGLDMSMPGDGLYWQDGRSLFGEQLSIAVLNGSIPMTRLNDMAIRVVAAWYQLGQDSWADEGPNFSSWTNDEYGYLHAGSSSTQDKVVVNKFVEAETDKSRQLARQVAIEGTVLLKNDDALLPLSSSLSELGSSTRKRVAIIGEDAGPGKGPNYCDDRACNQGTLAVGWGSGATDFSYLVDPLTALNSSFDTAAVEITSSLTNSVSTKMKKTLNEQDLCLVFGNADSGEGHKIWATQRADRNDLEIQKGGNRLIRTVAEECGGPVVVIIHSVGPVIVEDFADLPSVKAIVFANLPGQESGNALADVLFGRADASGRLPYTFGRSLADYGPGAPVLYYPNSIIPQVDFKEGLFFDYRHFDRAGVEPRYPFGHGLSFTTFDFSDLVITSLKSKSPLPAARPPSSITPPSLDEEIPSIDGALMPKGFTKLRKFVYPYISSKDSVKTGRYPYPDGYDAGQKPSPAGGGEGGNPALFEEYVQVQIRVANTGRRKGHTVVQLYVSFPPSVREPSTGEVIDTPVRVLRNFTKIELEAGSEEVVTLGLTRKDLSYWSVVQQNWVMPDGPFTLAVGKSSRDLVLQGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2E2</accession>
    <name>A0A1C1D2E2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Wings apart-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2E2"/>
    <dbReference type="STRING" id="86049.A0A1C1D2E2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02774"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04893"/>
    <dbReference type="eggNOG" id="ENOG502RZXD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="78088at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wings apart-like protein C-terminal" evidence="2">
        <location>
            <begin position="430"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="806" mass="87164" checksum="DF0CB846F17595AF" modified="2016-11-02" version="1">MMEFPVTRRKVNTYGKGARKVRVHDLFDVGAQPLFESKRSSERHAPTPAAPGQDTYIAQDADGVHGRATTVHGTGGTEEDAIATRPSILPTSDTSAMFDIQSSEDDSGKLKSNRHSKKRKIVTVGSARSDGFTSATSDTKVAIEKVKGAQDLVGNDKPDTLQHKSANARRMIGGSKSDKAPPTAKRPGKAGAKSITRRAPASNTASSSSVAASKTFLSRELQASSGSSADMSDASDHSAVSGRSTPKRKRVVSDEGVASPTPSDLHLTALRLTPGSGSQRSHFSSEDEEMKDAPSATASRGRARLIDRLDAPRTQSAGNLSNPTLQKEVSQHLKEPAVNNAPSKNPTRPTLEKQTSSQLVAPAGRLRATYAKQRSYLSDMVDSLDGDLPASTSQASSQQSYSQAMSFTSGITPTDMDLDDSDEADTGSRIKSIHELRRGGAVRKFDLELQTILEDIESTTKSLRVTGLLQLADKLHEQMFLRHFQDSGNFQRLMDCVNDSMDEVSALFVALIFQSVISTESSTPRVLLQVLDALYRLPPRFLSETLSVSRLAKDRSQNLSKLLANDIAGFEKRRVTVLGQPSLDVDRILLGTIESAQRKLISLKEPLPRLPRKLVAEVLSQFTKPRGEIAAGVTSRQTETIRLLLSFLEIACANGELAGSRFPTSRLHELGQAVASTMREARHAHPEVVHSCLRLIVSLSNNEAEVCEALSKGELIDAVFQVVDEHFLTLAGLAALEKEFDNARLESVILAVGCLLNLAECADAAREKMLIRDSGGKSLVHRLIDIFNRHVDHATEVGLTVTNSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2L2</accession>
    <name>A0A1C1D2L2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_00018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000001">
        <property type="protein sequence ID" value="OCT55123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2L2"/>
    <dbReference type="STRING" id="86049.A0A1C1D2L2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00018"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00008"/>
    <dbReference type="eggNOG" id="KOG3912">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651208" description="Integral membrane protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT55123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="48282" checksum="CCA4C2423FACF198" modified="2016-11-02" version="1">MAVKAVIPFLVGMMLLTGCSNTLLTKYQDQQCVRGCDSRNPKHHRTFEQPVVQTVQMFIGESGCWLVILGFYLYRYFVLRSRDAPLLYQPVSTEDEDDDDTVRPSSRGAAVDPALKPLVPNADDRAVLKGWKLVLLGLPACCDITGTTLMNVGLLFVAASIYQMTRGALVLFVGLFSVLFLKRKLYLYHWFSLVIVVLGVALVGLAGAIYAGDRNSPAPKETSLELVRAMALAARQVVVEAADPVVVRTVIGIFLIAFAQIFTATQFCLEEWILENYALEPLKVVAWEGLFGLIVTVMLQVILHFTVGVSKAGKYGYFDAAEGYHQVFTNRAIGISSLAIMVSIGGFNFFGLSVTRSISATSRSIIDTCRTLFIWIVSLGLGWETFKWLQVVGFALLVYGTFMFNDLVRPPIKALLPARTEAEREELLPEEPIEHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D304</accession>
    <name>A0A1C1D304_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D304"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03213"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651283" evidence="1">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="91" mass="10259" checksum="0B0C2996C79E930E" modified="2016-11-02" version="1">MAQMEVGENLLLSFFLLRIVKVLANKSGMDLSLGRACIELQELRELQPPSYYLGSFSTQMMRHPDTSNVMLHPTGYHRPPFGFPPSTFTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C655</accession>
    <name>A0A1C1C655_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT43983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C655"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00145"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02061"/>
    <dbReference type="eggNOG" id="ENOG502SS9Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2865667at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT43983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="141" mass="16254" checksum="34B66EE3BECA021A" modified="2016-11-02" version="1">MDHSMLQDTILALEDSTWRALMHSGGDLLPFLSRDCIMLFPLGLKVSARTEPNLEDVMKSDAFVPWRRYKISDVEVTALGPEAALISYRVKATRQHITEDDDTRQDEFKALISSTWRKDPEAGKFLMCFHQQTPYEEDLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6H9</accession>
    <name>A0A1C1C6H9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6H9"/>
    <dbReference type="STRING" id="86049.A0A1C1C6H9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00582"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01016"/>
    <dbReference type="eggNOG" id="ENOG502S1QC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5366531at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT44077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="710" mass="82829" checksum="2A80999CA56DE72D" modified="2016-11-02" version="1">MSLIGTRLTDKPQYRHDIELWEMLLIAQALQNGHEGIKAIWRGMKFRGEAFRLEGDDPRVDALWKTFLSAGAEDYQFLWSMCKEAKLLRYKRPHLFAEIVGAALEGSNPLQAPQFAAFLREKHFRGREDLLATFSAACESRNPDALRAFCQVYDMVRRNSIYAAITSTLWEQERPDDAFMMHSFLISRRDLPPRFELLEPFINYLALHNESLDEFLSPLTTAGVSFEAQARRLWSMGRSRVTGLPAESLNIVASKTMGTAPNKLSDQFVARAFATRAFSFDFAVHSLRMIGLIEVGPLAVRQMSATSPDLTTLQARFQKLRELEIDTGASVFVRVLRNVCDAGYWEMVEALVDNDLHHEVFEDVDVQKRLLTEYYRKQDWRQLNRTLAILNDGRFDDASKRRAANLLLIAMVEAGDWSSVINCATSLQERGWQLSSAFPRALAPFFRTTAQHLPSPLQGLSVDHTSLIIGLMQKALACRTNVKFKYWRQAMRALGRQGRLEELEALVYWVAEWFRHDGLHREVLDVPLSRDWVDWKDLFDSKFQKSLMSWCFRPRKGMRIVSAERCLRWTRVLKRLRDGYGIEVKEYVIRWEFIKRLRRLFAIGMQVKRHNASMRARNRVSITRYWTLYDKMWDMKPAGQVNYDDRVKVCLHHRKLSPLKRRRRHDHWMSRRVAQKLIRPIPDEHGRNSVQGDIVGYRDIFNASWEDYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6U5</accession>
    <name>A0A1C1C6U5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-type alcohol dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6U5"/>
    <dbReference type="STRING" id="86049.A0A1C1C6U5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00654"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01116"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="21"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="363" mass="38092" checksum="F939DE4E26F03988" modified="2016-11-02" version="1">MSLPKTTPAWIVERSSGDKPGSENLKFVKDYPVAELGENDCLVQIQAVSLNYRDLVIPKGLYPLPLNLPTVACSDGAGRILAVGSKVTQFEVGDKVVTQFTQKHQHGEPTPDMFDSALGGGAPGTLRQYAVFPAWGLARAPSNLSPTEAGTLTCAPLTSWNALFGLQSKAVQPGDVVLTQGTGGVSLSAIQFAKAAGATVIATTSSDDKAKRLEKLGADIVINYKTDPNWGETAKRLSPGKAGVDHIIEVGGPGTMAQSLKAIKLGGVISVIGFLGGVGHEKEPSTLEALGAGCIIRGILIGSKAQLVAMNRAIDANNIHPVVDEKIFSLDNALDAFEYQWQQKNFGKVVIQLAGPVLGQKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C701</accession>
    <name>A0A1C1C701_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein HbrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C701"/>
    <dbReference type="STRING" id="86049.A0A1C1C701"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00569"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01171"/>
    <dbReference type="eggNOG" id="ENOG502RZ40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2290221at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="826" mass="89094" checksum="D81036D94A6AFC64" modified="2016-11-02" version="1">MEPPPPQRRIARSPVPPTSSMSPNASRSGSKQSNRPGSSGSDTSGSSSLSVVKRSPYNQQLPTFVSHANASNASLPSHSRPSAQYMPRDGAAKHNLGPPPEHLQKHRPRQHSQGYFEPSMPSASLASQSQLHDQPGMPALNPSQIAAQAAMQHLNVTNHSRKRSQTVPFPQEQTQPEGRRNSRGSAGSHEGQSPAPAPEQQYRNGLIGTNAAATAASVVFPKNFASASTTSLVEEEKSKKGLKRFRPKHMVLSRDKDKEPKDKPLPSPNRLAPSGLSKVMNASTASLAESLSSNNSSLYQLANPSSSTGIPMLDQREQKDKHKHHGFRQKLKLKDKDDTYALPLSSANSNSRPVDIHNPQSLYSFAPPSPNPTSNFAKSVSGLDLRHGGRALREKKKEEKAQQAAFANLEPVYSRGESDTSEWPSLGTSFTNQSVSNFNTYSEVKEAGANFGLSNMSADDAWDLLRAKILVAFEGEDVRIAVEDLNKLVTIHVQRCVQKKDPSIIIGDLEDLLKTGFLSLNHTLRGVSDNGLVPRLVATWMDVFGKILPFMQAVFLPLDQEFKGRGTILTGPLMAAEFWGALPSHDSGGKLSSSPSTGEGIDFVVAAGEELEVRRILLISYRDNIILPRYEVLKSTFSRLSLDSINASLTQHDGGNRNRGNSGGSDRPGTAQGMEYGSYNSQSSTLLGSMTSGGRSRATSNLSVVSNPAQDVAFQSFSSPPAARPTDSSSSHVTETVGRMLQCLSVLCSIQSGDDAQAKMEELNKQLKLNWLGRGRTGRNRKGFVGSRVRPMGSVGSTIRGLDRDGSPTPTPTRQGTVSRQSDDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C742</accession>
    <name>A0A1C1C742_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytidine and deoxycytidylate deaminase zinc-binding domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C742"/>
    <dbReference type="STRING" id="86049.A0A1C1C742"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06172"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06992"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="288" mass="30471" checksum="0ECB0524CCD1CA48" modified="2016-11-02" version="1">MSPPGPTHDTGPSTSTHLHYLRQCISLARLSPPKSTNFRVGCVIVSFPAIDSSRTVTGTGTGTGTNTNAEDALPKGDDDVLSTGFTLELEGNTHAEQNALTKLARDYEDRERTQGKKEPKAGGLGAVLTPQRNVHLYTSLEPCGLRLSGATPCVQRIIATREDNPDGGIRKVVFGAREPGTFVQDSQALKMLDDAGVPWEHVAGLEAEILAVAKEGHHDASGSGSGSMSVSGRAGSADGDSGATAVVGNTPAPPRATNVDDISPEERKRQEQQPRNPKKRMMEVDLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C745</accession>
    <name>A0A1C1C745_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C745"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06393"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07051"/>
    <dbReference type="OrthoDB" id="10347779at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="153" mass="17058" checksum="C555D512E39DFD1E" modified="2016-11-02" version="1">MAQDPSPDRPFSQSQLNSTDLTSELCIQTDRNHPQHTSTCPRCQESMNRQFDNVLRTVMLREGWTEDQVNAVSLRGFATKAMAELAPDASAGPLEVQRQVYARNCVDELQARIDATREVHKARINEPPKGVVMSPPGPVARRGTGKMKCQKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C792</accession>
    <name>A0A1C1C792_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">S-adenosylmethionine carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">slc25a26</name>
        <name evidence="12" type="ORF">CLCR_06097</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C792"/>
    <dbReference type="STRING" id="86049.A0A1C1C792"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06097"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07075"/>
    <dbReference type="eggNOG" id="KOG0768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="111"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="217"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT44380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="311" mass="33571" checksum="9909C0B1BC83F064" modified="2016-11-02" version="1">MTGQDVALQEARRPVVTSFWTRSLIAGAFAGLTVDFSLYPLDTIKTRLQSNLTSTNNGGILPRHTVRGTLRSMYAGLPSALLGSMPSAASFFVVYDGVKRELIDNDTPSTHQAYAHMLASSLGEIAACAIRVPTEVVKQRAQAGLFGGSTLLAFQDILGLRRSDGYTTMVRELYRGGGVTIMREIPFTIIQFSLWEYFKASYSARQHRMHGRQSGMVSAAESAVFGSAAGAIAAGLTTPLDVLKTRIMLARKESGVSSERAGAVIVLRQIWAQQGISGLFRGFVPRVGWISTGGAIFLGTYQYISNMLGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7D1</accession>
    <name>A0A1C1C7D1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_05983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7D1"/>
    <dbReference type="STRING" id="86049.A0A1C1C7D1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05983"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07090"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025774">
        <property type="entry name" value="PiNMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF11">
        <property type="entry name" value="GERANYL DIPHOSPHATE 2-C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51581">
        <property type="entry name" value="SAM_GTMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="6">
        <location>
            <begin position="189"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif I" evidence="4">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif II" evidence="4">
        <location>
            <begin position="206"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="357" mass="39341" checksum="DB2F5BDA1152801A" modified="2016-11-02" version="1">MGDPSETASSNPATEHVGDKYEVPAFEPHSSFDSLKQRIRHHYELASDYYYSLWGQHIHHGYFLDANETKEAAQVNLIDLLLEISQLSPNSTVLDVGCGIGGTTRHLARQKGCTVTGITISGRQVQIANRLTQEESAAKDQDQDLDQDRDPERKPEGPPSAPFASPEPATTSSPPSSGFHALGKLGGKVQYLELDAETMDQHFPSSSFDVVWISEALSHLPDKGLFFRNAARVLKPTTGKLVIADWFKDADLTPELRERDIKPIEDGMLLPPLSCMGDYVSMAEAAGLTVFHPPRDISAQVARTWDISWQLVSSPSLWAFAISQGRDGLAFLQAFRAMRRGYADGSFRYGVMCFAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7H5</accession>
    <name>A0A1C1C7H5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7H5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06479"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="88" mass="10702" checksum="FBFF6AA70733B95D" modified="2016-11-02" version="1">MCRANFYSEFARLTGLNDHSPDHTDHRPDHTDHRPDYTDRNSDHNDHRPSIEPMERKYQPYHHDNANTYFRKSYLVGLDEYNFQCNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C804</accession>
    <name>A0A1C1C804_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_05718</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C804"/>
    <dbReference type="STRING" id="86049.A0A1C1C804"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05718"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07269"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="116"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="432" mass="47601" checksum="5DCEC70DDFC6154B" modified="2016-11-02" version="1">MTEKLAIEQGAYACHDEVCDGVTRGRIANGSDKEASTTKLVNPLAGIAKHDLMQAVESFAAEKDLLDILPLLQKGACVAQASVPFAEIEELDFDELESLQYEIAHKWKHPLALYITVFVCSIGAAVQGWDQTGSNGANLTFPVEFGIASGSNRDNWLIGLVNAIPYISSAVFGCWLSDPVNYLMGRRGATFMAAIFCIFTPIGGALSQNWHQLLVTRLLMGFGMGLKAATIPMYAAENSPAVIRGALVMGWQMWTAFGIFLGFAANLVVYRVGKIAWRLQIGSAFIPAVPLALLVYFCPESPRWLMKKNRYRKAFESLCRLRRHRIQAARDLYYVHAQLVIEYEMAAGSTYATRLRELVTVPRIRRSLVAALVVFMGQQFCGMNIIAFYSSTVFVQAGASEHTALLTSLGYGIVNFAFAIPAIFLIDRIGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C832</accession>
    <name>A0A1C1C832_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fabG</name>
        <name evidence="4" type="ORF">CLCR_06209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C832"/>
    <dbReference type="STRING" id="86049.A0A1C1C832"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06209"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07281"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="253" mass="26167" checksum="D303139E667999A8" modified="2016-11-02" version="1">MASFTGKNVVVTGAGSGIGMAITLTLAERGATVWTVDLSANPPDELKSWIDAGKVHFEGGIDVADREVCRRYMGKVASAAGRLDGLVNNAGIGLYEGPIASDEAYDRMISVNIGGVWNYGTAALRTMEKQEPQGPFGSRGSIVNIASGAGLRGVSGLAVYCATKHAVIGLSRAWQEDFGKFGIRTNSVAPGATATAAFVKRAEEEEGFLDTLPSNPLGRVAKPSEIASAVAFLLSDEASYVAGEVLSVTGGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8F6</accession>
    <name>A0A1C1C8F6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_05935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8F6"/>
    <dbReference type="STRING" id="86049.A0A1C1C8F6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05935"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07460"/>
    <dbReference type="eggNOG" id="KOG0373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903432">
        <property type="term" value="P:regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="205"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="403" mass="45024" checksum="4CE7CAD19BF143C0" modified="2016-11-02" version="1">MGAVKVPVPGPARLKRSAGPDEWLEAAKNCKYLSEYHMKQLCEIVKEYMMEESNIQPVSTPVTICGDIHGQFYDLLELFRVAGGMPNESAPETPVTPANIITAADIEPPSTITNPKLKKKLRLGGSEHPDTPSEKSSISDAEEIPSSQQSEIEDERSESGNIISRKQNANFIFLGDYVDRGYFSLETLTLLLCLKAKYPDKITLVRGNHESRQITQVYGFYEECVQKYGNTSVWKACCQVFDFMTLGAIVDGKVLCVHGGLSPEIRTLDQVRVVARAQEIPHEGAFCDLVWSDPEDVETWAVSPRGAGWLFGDRVSQEFCHVNGLNLIARAHQLVNEGYKYHFKSQDVVTVWSAPNYCYRCGNLASVCDIGEDMKPQFKLFSAVKDELRHVPASRGGRNEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8N0</accession>
    <name>A0A1C1C8N0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8N0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05816"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07542"/>
    <dbReference type="OrthoDB" id="4157871at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="501" mass="54583" checksum="197972E2B4F72DCB" modified="2016-11-02" version="1">MSDTIEQHSSLAPSPTRLRPESPYPNFSRPRWGHHRSYSTGLPFGYTKDAPGKSQQAVSRQMNARYHADHTLIEPVSGQNRRVLETADDGTLECSQKRNLAKERHCGEQDVRDAFERWIVSDKARKRLKQPYFAREGADPQYSPDSVHPSGVHGGHVHEDAQEEGPLYEKVDGVVMDTRPGESAGPYVMEQTLPEIEAHDIREIQDRSTNRSVGSSAAEDFQATLSSSSTDSSREGSGASPQLWSESSGSESTASTDNGVLKPYQHISKEFMPSSMDEREDGRQHNKGYQGTLHPGISELDSRQTPSAELQSTNAVTIPPSPLGVIGEEERSNVAHSRVSNTAPVPNVKGVRDVEIMGHLPRASATAKKESEPSMASSPQHATSQSHLDSPPRVLGTAGIGGGGQVYELEATAPLKSGNNGTKFSAPPIDHDSTVDEPNVFTKLEHGISRAAHAVHLKVKKNVTFSKVDDVRFMTPSPHPPSLDNTSAVEVDHERRVCVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8N9</accession>
    <name>A0A1C1C8N9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8N9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06440"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07573"/>
    <dbReference type="eggNOG" id="ENOG502SD1T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9999611at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="10257" checksum="A4088B01266CDA0E" modified="2016-11-02" version="1">MSSNQSADSQPSMIGGHAKYVQGVVSSTLGYESGEQTKAEAVQQMKDAKAHSDGQPTQSSILGTVENTAGKLTGCEGMAQEGQQRIPNKKGIEEQSGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8S9</accession>
    <name>A0A1C1C8S9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 15">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">erg8</name>
        <name evidence="17" type="ORF">CLCR_05824</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 15"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8S9"/>
    <dbReference type="STRING" id="86049.A0A1C1C8S9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05824"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07530"/>
    <dbReference type="eggNOG" id="KOG4519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262935at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="194"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT44858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="496" mass="53315" checksum="866854F5484579AB" modified="2016-11-02" version="1">MSPPPIAVSAPGKVLFAGGFLVLDRQHTGLVFGLNARIHAIARQRPSAASAEAARGDLNDHNGHTGLVEVESPQFRDARWLYRVGFGGGLDGGDDAAAVQVEQVRDREDAGFTASGNKFVETTLRYVLTYVARGSVPGGKEGISARGPVKVTILADHDYYSQPASSGALSLVRGQSSSGTDEWRDFNVRLSEAHKTGLGSSAALVTSLVSALLAWYLQKREFDDKTPLSQRTIHNLAQAAHCAAQGKVGSGFDVAAAVYGSCLYRRFTPTILENVGEPTSAGFGERLHLCVDDLHRGSKWDVEVASQAVRIPQSLLLVMCDVDCGSETPGMVKKVLQWRKERTDEATLLWNALQQGQEDLCRELRQLAAVEAVDSNFTALRDIILTIRSLVREMSMKSGVPIEPPVITELLDFCSSIPGVVGGVAPGAGGYDAVALLLRNDPGVLETLRARLEGWKSQDDTGAKIGNVKLLGVKQENDGVRIEAGDRYRGWVDPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8T1</accession>
    <name>A0A1C1C8T1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative rRNA-processing protein ebp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ebp2</name>
        <name evidence="7" type="ORF">CLCR_05918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8T1"/>
    <dbReference type="STRING" id="86049.A0A1C1C8T1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05918"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07601"/>
    <dbReference type="eggNOG" id="KOG3080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000280">
        <property type="term" value="P:nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="391" mass="43311" checksum="987B0CD9E0B6094A" modified="2016-11-02" version="1">MAKKSKLLAALDAHKGRDYQAEKRKAQVKAAEKRKRQKLDTPQQAENEDDTIENNDQASHTAEETHQPVEPTEKDDFADFDEDENAAVDDKASTTIPQSVQSTDAAASASEAEDESDVPVSDLGDSDLEDAIPYQKMTINNGPALVASRTRIAVVKNPKTTPFHHHNSLISSLEPATESIPDPNDDLTRELEFYRIARTAVLSARDLLESEGIPFSRPADYFAEMVKTDEHMGRVKQKMYDEAAGKKAAEEARKLRDARKFGKAVQVAKEQERAKEKKTTLDRIKELKRKRRGADTGKVAEGNVDDDLFQTVDVEKAGAKDRSGRERGPGFNAKRQKRDQKYGFGGKKRHSKSGDVASSSDMRGFSAARMKGKGGKVKAKRPGKSRRSATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C991</accession>
    <name>A0A1C1C991_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">dad4</name>
        <name evidence="18" type="ORF">CLCR_11222</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C991"/>
    <dbReference type="STRING" id="86049.A0A1C1C991"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11222"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07713"/>
    <dbReference type="OrthoDB" id="5516652at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT45041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="72" mass="8412" checksum="9D98AE1BCFB75E7B" modified="2016-11-02" version="1">MESPHEQQQALLLSRIIANIEKLNEAVMMMNRNLQEVNIQNMNVELVAQMFKNYQSNVLFHLEATENLKDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9N6</accession>
    <name>A0A1C1C9N6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9N6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11225"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="128" mass="13837" checksum="D7A648A4E9DFA63B" modified="2016-11-02" version="1">MMESFMIGDALGDRNSRIRKAAKAADDVRRKEHAPQDSTYDDIHVTLRHRFATIGVSGYEEQAGTSGQVGATEAPQGGLLVILAKRKGLGMETRDLTARHWFQAAAAPQTDGIRGGTWVSSAAELRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAC3</accession>
    <name>A0A1C1CAC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAC3"/>
    <dbReference type="STRING" id="86049.A0A1C1CAC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05834"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08045"/>
    <dbReference type="eggNOG" id="ENOG502QWCE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3189033at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="489" mass="55086" checksum="BAC848EEA01875A5" modified="2016-11-02" version="1">MASPYQNPNPNLPAELPAELPAEIPAQSGPQILSTNPPTEQPLNIQTGYGTGYQPQEQYPPPPPQPPRPQQIVVPVPSFEPPPPPSLPQRPDHEGVDVGAQAPTHAQPPPYNPADYAHGQQYQGHQPFQPPPQRIKQTFPEDDNPSNPIHYIRDPHKLIGYLVPFPRPVLPNVDAETIPKRFMIYTPPPPPLSKPAEGEKEAKLHKVQRKWQEEVRSAKTSTAKTASWKGVKSKATRGIDWAIHKTTSSNLDFLGRVSPGPQSDTEKDHSDNEGPDTHKTVDVEEMVLIYPPAMQLTNEQMREEFVNTMLRTKSKAQRDTVIATGLMPVAYGIDILATFIWPFGGLGEIDTVWAYSSFRGAKTARSVTKRLTSSTHAGSPNHEDEANKLRLTFTHSQRIEVLRKYLDAECHKVDPKLFPRYEHSPTESDVLEAIGWAPSRDTEKTNWEDEHWEIQEVKEDLKRVFNKAASEWRKWCKLLAEKPEKAMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAY3</accession>
    <name>A0A1C1CAY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BNA6</name>
        <name evidence="16" type="ORF">CLCR_01637</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAY3"/>
    <dbReference type="STRING" id="86049.A0A1C1CAY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01637"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03549"/>
    <dbReference type="eggNOG" id="KOG3008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.20:FF:000003">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="15">
        <location>
            <begin position="54"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="14">
        <location>
            <begin position="135"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT45646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="313" mass="33871" checksum="BAFF636DBBB4C58D" modified="2016-11-02" version="1">MTSAADLPLPTSVSGSHDQHGSLSDLLPSHFTTLVTTWLAEDTPSFDYGGFVVGSQPRTAQLLCKSAGVLAGVPFFNEVFRQLDCEVQWHYNEGEFLDPKNQSGKIKVATVKGPTRKLLLGERVALNTLARCSGVATRSRRMLELVRSAGYRGTLAGTRKTTPGFRLVEKYGMLVGGIDGHRHDLSSMIMLKDNHIWAKGSITNAVKAARAVGGFALKVEVEVQTEAEADEAIEAGADVVMLDNFDGEGLKVAAKNLKQRWKERGRADVLLESSGGLTEANVEAYINNDIDIISTSAVHQGVPHVDFSLKIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC11</accession>
    <name>A0A1C1CC11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00507"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10343"/>
    <dbReference type="eggNOG" id="ENOG502RQVW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4160190at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="244" mass="26979" checksum="6B510F9B1DC7A5F5" modified="2016-11-02" version="1">MSSQSRSLDISDWPLQPTTRQGSITSSLSSPSETTSVHFANVNLPPTPALSGRSDNGRLSSNGPGNSVHVPLSKPVHISFSKGSKLFKLKYSQIQLRRDAAGYLKQIELSDPAGLQSAFIHSFPGTKIPIPHLEQPVTSSTSHISRVSFLEEQNVQTAQTLFQAQPQYTFETWEDCVHFQEALLSQTVVFTAGIAEAKSKGRGEECISQNLRILRSRTGKQTILLFANSQRKEKKRYITIPRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC65</accession>
    <name>A0A1C1CC65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC65"/>
    <dbReference type="STRING" id="86049.A0A1C1CC65"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00357"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10351"/>
    <dbReference type="eggNOG" id="ENOG502RU3A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038769">
        <property type="entry name" value="MTC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1295"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1332" mass="147711" checksum="DDF8354F39D234D8" modified="2016-11-02" version="1">MSTPLTPPEGRAAGDKVGDGDRPESKRLSLPVFHSVRDPSNERDGRASRTSSPASGSDSHRTGRRTPEPGHNGLLERLSFGGGSARSDHSGEKEKEKEKENEAPRHNVLRTSGGFLLEPISNPKRGSRASATPLRKSSEKKREGGESELTIAKRRHKTNGYSNSSFKSSPLASEVKQEPVIHNSPSPDQLVAGTDVRRSLSSSQNESRFTGSSASTSRNVTAQNTPASKVGYDNDPARIVNMALSLSEGRRRMASGRRYVSTEHGDRRVLSVTAPVNPSNTVRRRSIAPFMATNRQLSQSRSPGRRSSAKHQDTGGGLPNQPLDTSVDEHEDDLELDPSFADHVSPATAARVEKAKVYFELAHEHRRLLSHLPPLRRPGTPAPPGGPETQQKAYNPLQYVRNRKLRIWEKTPINSEAEGWHDVEKVRAWVDAVISSHTETQHDSLECVRLPPLDLRTVETANEANDDPEEEPRSTVSHRTPDQLHPKPSRPRSDWVTHPADLIADAFWLEQGLNKTKIQDRDNNLIYPPDTQFKFSGWRNRTPAVEVPSRLQQPSPPPESHNDSFRDPPPSALPELPTFKSAHHLHRSGRHDRRRDIIRDSLQPKEGSSSRERSRIRKKLFQDSSDSEYSSLSSNDERGRKRLRRKRQEAPTTDTWEERHSPLQSKRHSQPIGNGHGDSSQGSSAPTSKRGSIDHSALNKLFRVDSFKKASPLTRSRNRQDGSRPRSAAQGPNRSSLEHEPQPRASSDYDTTTAPNSPTNLEWPSIAINLSPPPSRPGSPARKPISTILQPFHRKSHKEQGSISTNDFAHVPHVHSSHDPVKHTKAADSRGQSPMTRGVSPLSRNGSHSVEADDVVPQLSNEQRHSVASKVSTRSTVTAGGDHSRLRGIFKGGRIAEIVGNEVSRVGDFIWKREPPTLYRHRGSASEGSIRSFASDSDKEHHHHQNGTVLKTPPPLARSRSSTLDSTPSDQVSPITTKAGSSNNDRPRYNNPNLPTFTSPFQRDRDQQEKKQGLLAPEDAVIRKDSADNTPHLTVRPRSNSRSPRLAQLPKLDTGTPNTPNELNRQNTYGFGAALDLSRSRDASDQLNSVLGPVTGLTRLRPVKSAGDVSSGGGSQAGLENREAGDVSWRDIERAYALLYTSTVKAREIGRRADDSGEELPKYLYESLTAENKALHSTKPLRVRKRERHIVAAQNIMKTLDGHSSTFNTKLHSFTSSLIPALHIELQSLEDQVENTMTPQVRVTADSAGELSMKLSTTSTLAVKELNDTIDVAFRRKRRGPIRLFRKMWFAGIEWTVVGLLWLIWAVVSVIQAILGVGRCLIRGARWMFWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCA6</accession>
    <name>A0A1C1CCA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCA6"/>
    <dbReference type="STRING" id="86049.A0A1C1CCA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01262"/>
    <dbReference type="OrthoDB" id="4367324at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="283" mass="31613" checksum="D85AF224DF0D5BDA" modified="2016-11-02" version="1">MVQTLFDYLTQRNARLVVHISTSPTYTNNEGWAPVEAIEQWEDFDLASLTKRYRQSLDADTSLTSTVEAAEEAGHNVICDEAALTIFLGSANISMVSRALPGSLFLSARSRIIAIPSVRPDWGAGDANIHYTHPRGICQALVCGDTKVDWDVERAMRLVGDGGYEDQPDAYLPEGHRRVLSDTSTITNVSDISDSFSTMSFRPKPQDEDVAALEVKIVPWDHGSSKETINIDLYFLTRLASESRELSHHYESLDIDIKAQGKEKRKRPDDSPEQSSRRDSRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCS3</accession>
    <name>A0A1C1CCS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peroxyureidoacrylate/ureidoacrylate amidohydrolase RutB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rutB</name>
        <name evidence="4" type="ORF">CLCR_01295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01295"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09235"/>
    <dbReference type="eggNOG" id="ENOG502QTD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF9">
        <property type="entry name" value="FAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="27"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="240" mass="26246" checksum="D43FF660CC4AAD38" modified="2016-11-02" version="1">MHSSLNRSVLAEPYHYPHDASFSPATTAIVVIDMQRDFCEIGGYFDCQGCGVEDARNLIPTIQALLSAARRAGFPVFFTREGHRPDLSTLSSRERFRSRKNPRQLGIGDRGPLGRFLVRGEPGHDVIPELEPRPDEVIIDKPGRGAFAHTDFELLLKMRGIRNLVLCGVTTDVCVSTTMREANDRGFDCLLLEDATAAATPQLHNATIESVKMEGGIFGAVAQSGDVIGAITRDAAQPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCV3</accession>
    <name>A0A1C1CCV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="10">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="10">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pan2</name>
        <name evidence="10" type="synonym">PAN2</name>
        <name evidence="13" type="ORF">CLCR_01044</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="10"/>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCV3"/>
    <dbReference type="STRING" id="86049.A0A1C1CCV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01044"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09169"/>
    <dbReference type="eggNOG" id="KOG1275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000459">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000028">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="488"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1095"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1114"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="885"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="887"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="994"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1057"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT46360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1183" mass="130817" checksum="C628094A8E49EFF9" modified="2016-11-02" version="1">MEADWDEITRIAVPSSGLHAIPPPASAIAFDDVQELLWVGNDQGRVTSFYGADLQRYVSVKAHLGEGPVKQLLVHEKGIISISASSVHSVSRRGLTQWHIAHPNMSDLRCMTLAGVGTHNLLIVNGGHSTFFVIDLDKGQVVSEHPAPAKYTIMKKSRHICAATDDGNVHILSLTDYRLLKSWKAHSSAVNDMDARNDFLVTCGFSVRQMGVPIVDPLANVYDLKSLTSLPPIPFHAGAAYVRLHPKLQTTSFVASQTGQMQVVDLMNPVNVMLKQANVQFMLGMEIASSGDAVAIIDTNGWIYLWGSPSKVRFNNISKETEFADPPPQNVPHVDWNDAPLNTIGMPYYTEPLLSAWPSHMIFEVGAPPPTIEPSLVFHMQTAEMGHYAPNLNPRKLLRYQVEDTRIGHVPTSIAAPKFLSERAKDQPANGTGTKLADAAEALAGVSLNGRAQTDEERMLKYSNVEIKYSRFGVDDFDFRYYNKTPYSGLETHIANSFVNSLLQLYRFVPLLRNVAIQHAATSCVAGNCLLCEFGFLFDMLEKANGQNCQATNLLRAFGASREAANLSLFEHLSAANVTPLSTNIQAVNRFFLKQMAQDYAMIASNSDGVDEVIATKAFEAIRCMYCNNETSKPASTYVHDLVYPQLDSKHSTRYIKFSSVLKSTIEREAKNRGWCSRCRRYQQLAIRKTIRQLPFVLMINAALGSNTAMRNLWETPGWLPSEIGLTVQDRNVYVFEGSDLALHIRNKSPGLMIYELVGFVAEIDTSERHQPHLVSMVNVEVSSSGPDVPPNHKVFPNWHLFNDFLVSPVDPREALHFNKNWKIPSVIAYQVKSAHGKLDHSWKRTMDTTLLYQHYSINGLYPIDGCKILGPQEHPAEGTPIALDTEFVELEKAEINVKADGTQETIRPAKSGLARVSVLRGQGEDEGVPFIDDYITIYEPIVDYKTRYSGIRPGDLDTQVSQHNLVPLKVAYKKLWILLNLGCIFVGHGLASDFRKTNIHVPKSQTVDTQYLYLAPGKNRRFSLRYLAWAVFKEYIQEETGLDEATQIDGHDSIEDARMALRLWRKFQEYEDAGIAEQMIEDIYRKGTKYGWKPPPRSIGGTLAPLDGMGTGAANSAVQSGRNTPDMAPVSSSVSGTPLPMSPPKTNGSASGSSSGGAFKLNAAGAGAFVPGNGIIKESPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDB8</accession>
    <name>A0A1C1CDB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_01823</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDB8"/>
    <dbReference type="STRING" id="86049.A0A1C1CDB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01823"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01202"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000100">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF2">
        <property type="entry name" value="HISTIDINE KINASE M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="534"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="738"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="400"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="639"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="674"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT46471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="895" mass="99322" checksum="6B6033E64A6BCB4F" modified="2016-11-02" version="1">MAQQPPGIDPFIPLIERQSLCLPSVRPGVPTQYGEDGFLQNLARHFPSAENNALEKVVQLKRELKTVDSDTFWKKLMEGMTEICHAQYGFVAKRVLADDHHSAVEMPPFGESGSCLLGVAFYYNDGDEQKAMHRDYNYLAWGSPCSYMKHDKVFLIPEHMSSFITHNPNALPFPAEGYIGIPLFAEGKCFAHFGMMWTQEGLDRRETTWSFTELLLHSLEDVIVERLLTGQGFAKSRTRTAVKTRPTHVIPRDAITPGTQSLKPYAKNLSHELRTPMQGVVGMLDVMHTTVQEQIESVADTSVRRAFQSLKDNIETIQDSAKRAVEAADNVVHAYDMNMQIPDTPSNDKESPAPASTGYFDYKPSRLIEGSDIHLNTYKRRRSSPTSWNFGNATKMRQLAPSKGVDVSPKSNTLRFPPPQIPTPQTLGSDSRIPTLFTPTSDFVTPGDLDTPSSKLLSVDSDNLPTPGLKHCRIRELIPTVIYESLRVGGRPDSAIGEPIDFGERIVVRSRSSNGHTSQKTIEWSVAPDVPETLYADERDLTKLVSAICLNAIKFTEEGYIILRARLSKSQKFLVINCKDTGDGIPEDFQPELFKPFSREDDSLTRTKEGLGLGLLVAKGLARRLGGDIILVASEVSGPNKGSEFEIKVPFEPSEGNNSRSATPCSRTPEAPKSISQPATSLTVPETSPSSLRDPRPSQIHMPSIEEHPTPGPRTPALTSPFKRDTIDRFLAQKHPLTFLVAEDNKINRKLLVNMLGKLGYKDIHEAFDGREAVRIMRELHTMERDCAKLKGQRPAREVDVILMDLWMPEMDGYQATQNILEMFQQPPDADASDCSHVAPPIVLAVSADVTDEAIARATKTGMEGFMTKPYKLADLQKLIVEFCVRSEGVAATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDQ0</accession>
    <name>A0A1C1CDQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium/calcium exchanger family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_01811</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDQ0"/>
    <dbReference type="STRING" id="86049.A0A1C1CDQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01811"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01305"/>
    <dbReference type="eggNOG" id="KOG2399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="760"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="793"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="823"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="846"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="888"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="943"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="973"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="106"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="826"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="444"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="684"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="719"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT46577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1004" mass="109779" checksum="911265A3C0AC91A7" modified="2016-11-02" version="1">MTRRGMRPVRQQGRAFYLTAFIITLLACYSFVRDSSHSHGHSAQRLAARSLEARDLECRLVHHAEDKCAFIKENCPDEEAGLISYLRFYYCSLSDAQPVAFLILVVWVSLLFSTIGIAASDFLCINLSTIANILGMSESLTGVTFLAFGNGSPDVFSTFAAMRSNSGSLAVGELVGAASFISAVVAGSMALVAPFQVARKSFIRDVGFFAVAASFSLVFLSDGSLRLWECITMVVYYIFYVIFVVVWHWWLTRRRKRRLAETAARLHHHIPDTQELEAPPIDEDDESRPASERTGLLRGQSSDTLPTIRTPGTPAWKIHDYDDDDEARDRYLAELQSKMRVSRPTRGERRNTMTPIRPSLIGALEFRSLMTSLERKATNAQPIGLRRYSDDASSTLTPIPATAPPGASQPELVSSQYLNVEGESPRRARAVSVNDASHLHIDTDFLSDRFPERGPENALASGESSPHPATKYTRPSANILQTLNEPSNQRPPSPKLVLSPSGSQPETGSLHSDAVNPRSANLLAPPATTFRRPDYHDEDRSGSRSGKSPPRSGPTLQVPILHTPHPDHSKGALRLEDFPPYVDSPMLLTPVGSRPPSISLPAPSMSPESTAHLGLLPDEEDEPLRRFAWWPYRYLPAPQVIYASLFPTLYGWREKSHIDRILGLVTAPSVFLLTITLPVVEPKEDKLRDPDPALLTPGGGPRSRSDSHVVATPGSLPKPGSSDGPPHPHGTGISRQMSDYVKSPNHDVDEVNGPKDWNRWLVFLQAFTAPFFVVTIAWANMDDNLNTTLYVKMVLGSLVFSLVLLLILLSLTSPDREPKYRPLLCFLGFAVAIGWISTIANEVVGVLKAFGVILGMSDAILGLTIFAVGNSCGDLVADITVAKLGYPVMALSACFGGPMLNILLGIGIGGLYMTVNKATQKHAKHPHKPIKYKPYEIEVSTTLMISGVTLLVTLIGLLIVVPLNGWKMDRKIGLGLILLWSLSTIGNIIVELLGYGGDTLISGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE20</accession>
    <name>A0A1C1CE20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE20"/>
    <dbReference type="STRING" id="86049.A0A1C1CE20"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02055"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01418"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="108"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="266" mass="29651" checksum="64AD916FC55B070F" modified="2016-11-02" version="1">MIDEIRPFGLRSNMLDGSPALLSTLPTMTTWAGFERNMAYKAGRIRRDAASVVGKEFHVEVTTLLPELTSSAVSTISLKMTRFQDWETQLVPTANGRIFFRYAGKGQPILLLHGVPQHSLMYHSIAPALVSKGFLAIVPDLPGFGQSIVNKGTALTSKNAADALHTVIKFLDLKELHLFAFDKGTGPAIVLARDYPDIIKGLIIAEYSLPGFGHEIAQQPSRVQTIFDHWHLGLFTLPEVAVFLIRGREEEFLTWYYWHTSYSGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE63</accession>
    <name>A0A1C1CE63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_02142</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 6"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE63"/>
    <dbReference type="STRING" id="86049.A0A1C1CE63"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02142"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01476"/>
    <dbReference type="eggNOG" id="KOG0549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650815" description="peptidylprolyl isomerase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="40"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT46761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="135" mass="14550" checksum="39A861D108A45F1B" modified="2016-11-02" version="1">MKLLTTVLLALIPLAASLPDGLEIEYQTPDISCTRKTHKGDKIDVHYRGTLQSTGKEFDSSYGRGSPLGFELGAGRVIKGWDEGLLDMCIGEKRKLTIAPELGYGDRGVGPIPGGSTLVFETELMGIKGVKKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEN6</accession>
    <name>A0A1C1CEN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02261"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02487"/>
    <dbReference type="OrthoDB" id="4149643at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="916" mass="102215" checksum="FA5C7F3DE5ABF5DA" modified="2016-11-02" version="1">MAQTRAVFDSARETEIGKGPAGSTPESPQQSQVDSLQENAWEDVQREPSLKLPLTSEDHVLADVTASIDGGAAQLNPDQGLATNITDILGQPDLTQRTAEVMTTNQNDIRGSIRKALQSGVLDIPPFKPTSDTNLSADKRITYQLPPALLESDYISTYRKLFDRSALVPDSNLPLSSQIMGFCPIWAMWIAEIAEEAKREKLLDRVFDMATKAWFEALRLGYKPDTGGAETATPRTPAKRPVLQGEDIPPGLRGRPRPKKETDPLQMPVLTAFGHKNGPRWPITAGELQAAGISMTRLQRRAADKSDLVEAGDELLRKVLQIYNGQIAARDWFDVEERTKLNPLGRDLQVYCLYEVLKSRDSIAQLRSYFAKFKTVKQKENTQRRIDEEQERQDLFAALALELEEDNPRSPTPSVFPSTSTREGSVSSAHMTKTAETSDLDRLRSLVDAIESTLKDSNFADMITTFELYGISEGDLISSTSFEDNASDFDRCQRVMQEMLFDAREWLKLSQNGEAQDVNIQELEMQINKKKEFLCGVYPSLLAELDAAKTAVGDDDAAASVVEDEFVSSDNDELMTEVLESAPTRSTKRSLDAEEDDALGTQSPDTKKQKTGDEERALRIEVPAPLVQLGVDERDEGPFASTGATAPTIELPASNSLQRPSLLVKLRTRPGFDPETLTSTKIFYEDGFRYRYSPESTVAQRFSINDTLRGYIESCTQQHIGLNNDWRYGRYQGLVHVDDPSRTTIVHGVWDLEDGSQSASFERFYNGDAEYTADLEDTFMSEIDGEEAEPRLPSPPLRTRKSSTKSGRKGATCSMEEDLRSTAVDAEKGRVGGRDRSKTRANSNINHHGVITRAKSAKLRVRLFMKPVPVPQESFVDDSMSMNRPKRRSATRKSYAEDLDDSDDDDDYAPDEEYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEY1</accession>
    <name>A0A1C1CEY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEY1"/>
    <dbReference type="STRING" id="86049.A0A1C1CEY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02429"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02362"/>
    <dbReference type="eggNOG" id="ENOG502S0QI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="455" mass="51452" checksum="FDE3C0F1BA7FC663" modified="2016-11-02" version="1">MPSYQSWGAAAHHSRLPPTPPEYQTAYLTPLSAVSDQGFYPSHGYQSRRSRDYNERYQTQPPAYNAQPSLTGPVSRHAHAHPSQDYAFSQPYHVQGSTYWPANAVGAPILPPIRVTEPLDHFAARYGTQHTEAKPKEDKPTGGVAQHLDYDMDLMSSFVAEMSQKLVTPESAPTSQFRKYVSQILSSTRLPSSTIMLGLFYLQSRMKQVKERGSSTSSSGAVYRMLTTCLLLGSKFLDDNTFQNRSWAEVSSIPVHELNMMELQWLTDFNWEIHGMMYDEDEGFFMWVEHWHAYEEKAQLAKVKEMQKLAPIETNLHRHHSIQHQPLMSPEGPIPPQYQQGAQYDTRWVRPYMSEYSPPSAPHSGPSTPDYYTASWSFANNGPPAYGRQSYHNDNGSAYSAQRNQLPTYAQTFGYASGVTPTWMSHGPNCGCSLHAKHSDYYFSHPGYTMQPVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFH2</accession>
    <name>A0A1C1CFH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DHH phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFH2"/>
    <dbReference type="STRING" id="86049.A0A1C1CFH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02542"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02210"/>
    <dbReference type="eggNOG" id="ENOG502QQ02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051673">
        <property type="entry name" value="SSDNA_exonuclease_RecJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255:SF2">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="330" mass="35955" checksum="06782861EDD82B9C" modified="2016-11-02" version="1">MAAKDPAYIIVLDQGSIAAPPVVDLPSTKSLIIDHHLSDHFPKDAQVVSACHYPPVSTSSLLTYEICKPLAPAIASECAYLACIGTHGDLGNTLKWSPPFPDMKETFKIYTKKSVNDAVSLVNAPRRTAKYDVITAWTALLASRDPKDLLSNGRLQSARAEINAEVEMNTHTPPKFSADGRIAVLRINTPAQVHPVIATRWAGYLNSKALEIVLCANSGYLPGMVNFSCRIARCARSRDPPVNIIESLKAAADLSTDGLKDRLGQSFARGHKEASGGIVPVEAFEELMSLLKIGEKPEKKNESEEPKQKKAKTVEKSPQKNTLANYFRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFZ9</accession>
    <name>A0A1C1CFZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03730"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01980"/>
    <dbReference type="OrthoDB" id="10444102at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="160" mass="18369" checksum="92AD6DC4B191FBE0" modified="2016-11-02" version="1">MFEGGIDREEALREPRAAFRHIPTHIGMAGQPVPEELQEPLFVSAGDAYDTDYVNDDCDPTTNVKEILLYFSACKHFIGLWCEELNVQHGGVVARCGCDRFDEKLATKQYGESAEPCLLCRSVRSPEDRALLRETVRKITDERELALWPFSQRRPRREIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG28</accession>
    <name>A0A1C1CG28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG28"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03426"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01910"/>
    <dbReference type="OrthoDB" id="4137833at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="522" mass="58590" checksum="896E1FE8192F608B" modified="2016-11-02" version="1">MARAIRIEQLLVHNSTSPPEHDRTRPRTPVSRKNALPKRQPAPRPTISVKTSPISPVSASSPDRARFSWELDKADLSAVRHHRKRKSPVDDEGFPICHKPTRLPRFSVNIFHTEPVNVFPIPNEGVVPRMVKYYLQVWAPQHGRALAFEGHPKPYQSLVFPHALQNGVLFEAMVALARVSWLLQERLPWQKDAALTRHRANAFAGLKLRMTSETTCADDTTILTIAALTTIDYVLGVHEGAENHVNAMQQIRKIRLDLKGDTPWQYFLLSVMRAYEALWQFVKDRNEATTSMAQLSIDSPMRSELPIYPSLPFNIKVCEALSKVSTSFNDMAMAGELSIQMIDILANLSTQARGDGSATPPNSPPSSPGGRNLLNTIADLRCLSVMATTPIEHKLCFGIIGTCVTLHYGSEKISDDMHETLQGLEDSLVGNGKPEPQEENALNAHRECLIWISVAAAGALDQSELLSAMSMVLDQTLEQYPDETGDWETLEKILKKFLWNDLLGKHWKRCWRKAMHRQSKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG47</accession>
    <name>A0A1C1CG47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG47"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03772"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="90" mass="10521" checksum="9535CF66A20FD567" modified="2016-11-02" version="1">MPLLEDWQICLSEAHLPDEQGLVLAFSEKYWRCLGNFQAKFHTRGRQRAKAELRNDDVPAACTTTEQLQQNTEDYPIEDPYGVRIWEIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGH4</accession>
    <name>A0A1C1CGH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Topoisomerase 1-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tof1</name>
        <name evidence="10" type="ORF">CLCR_03269</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the timeless family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGH4"/>
    <dbReference type="STRING" id="86049.A0A1C1CGH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03269"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01804"/>
    <dbReference type="eggNOG" id="KOG1974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="9">
        <location>
            <begin position="38"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="563"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="888"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1032"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="904"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="929"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="967"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="989"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1032"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1066"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1106"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT47582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1175" mass="134429" checksum="BEC1479843DAF73A" modified="2016-11-02" version="1">MAEDNPFTKAQTVDPEVRAYVYSLVNALGGSSTDDDGRYVLGDDALAVLRDLKRWLKLYDEKNNRLDVARCLAEAKLVGGDLIPILASWPEDGKENRLKARVALACLEVLVPLTWPLETGGEMTANHHRHTPYIQQAQVIYKAAILGCDTSNILRQVVRVGLPSIAVARDERTSRDEGILKLMLYFFRNVAVIQQLPNLPTQGLDVEVSRSATIEAFRNQDVFAVLLTICSNMRDDFNLQDVIVLDIIFNLIKGVNPKRLWMTQQERKTRGVTDLGAVLAVEQSKDRAAKKHQWSRHGRFGTMVWVKREGEKMSAVSGQDNLKDDQQALFNMDKTKKWNKPQQRRKDLDHTIHDFDRTTHLTDSAAEKLRNFVEEFLDSGFNPFFTHLRKAIEREAERLTDVNYRQFFYAVAWFLEAERVRRETRKREVKPDNVRTELNDESFSLVAAVLNQETFIMLNRFMQISFDNKEWQDLNASMRCFTQILLTVQEMAQSPLEEDQEIADNIQNRIFYEETTHERIVSILREYKDQGFGYLDASTELFHVFLRMLERYSKENVDMQIRSRRRARKKRKEERKQATEGDDPAAEDEESENEDIADVVQVSKERKFDFNRFATRFSTQNSVNTFVSLLTFYRDLSTEQLKRAHRFFYRVAIKQDLAVLLYRVDIIALFYKIINGPDGLEKNHAMYLDWSEFSRQLFKKMFKKLDQRPELFVEMLFSKINATLHYLKFGQEKQTVSATRAPADLEVRPAPGRDITEQIGIVVTVLIKDGKAELVQWIKKILGKAFDERHAWEAEAEAREAAMAETAEKDGATLPEEIAFGRPSSVTVHPTSEDIKTAMFRDGRLKLLMRLVGFEMLGDEDVLGASWIVPGSVSAAQLSVHKATVEQYEQTPWQSNDESESAEDMLRRASRTNKESFDDGEDAPRDGFIDDSEGEEDFLSPDNPRPKKSKNIIAELKARRKRKRGDVDDDDSADEVDEEAAARRRAKRAAAELERRRKIKSEAYIRDSEDESDAEKDRLFFENEEKLRQRFQADVEAKLRQQAEQATKPAGKGKKTKAALPVGGDQESDDDLLMADVDDQPETASSQPRSAGRPSDTEEAGEDDTPMSSRSTTPDISIAGQSKPQLEYTRAHPGFKATEADASALSSDEDEDVVRPAKPRQRIRAGFIIDSDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGI1</accession>
    <name>A0A1C1CGI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transcriptional regulator Ngg1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_03337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGI1"/>
    <dbReference type="STRING" id="86049.A0A1C1CGI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03337"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01777"/>
    <dbReference type="eggNOG" id="KOG4191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1232at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT47608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="658" mass="72776" checksum="178EFC58CBE6ECCA" modified="2016-11-02" version="1">MPPLGSASKSKNKMRERQRSRSRNTTPSSVLSAGTAPLGPTTTPLLELEMSKLLVPAKPSYTEIIDHLETQGSRLEPRSLNDIIDQLKHLSDSAEKRAELCEKAIRVIHEQKKDLESDQQDHDRQAEQARRAKARKEEATSQKNLKAKKRKDRPETYDSVEIKKEDEPPKTKLGRATSAPVDSPSPSKKTKLSPGTSSLSEVADSPDAAAAASARASPTKSDVSMSDAEENRVVHSQPSIPQQGFFPDPLAPDKVIYHIREVTPGMSDAEKKEIYQVTAFPTKDLSDQIAGTPPDKDFSTAKPANQIAASTFLAYVEPYVRPLTEEDIAWLRERGDRTTPFLAVPRSKRSYQEIWAEEDTGTISVESGDKLPLNHPRGNLEQINDDNLATDQVSTGPLASRLLSLLKFEHRSPPSDVNGIGDMNSFMADGNDTMDLDGLTNGHDPTEKPLPPAAAVADQAPSKNTISQRLDYIQSDERIKGELRHLGLLGQDENPDYDAHHDDDISERLRLLQAELRRVMIINGARKARLLDLAKERLAFQEYSTIHEDLDSQVQQAYLKRTRTLGKTKKGGPGANKPKAGTHGVGAPGTAVSVSRARDIGDSARMLMDRRKRWENCIGPVFKDMKHGIPDKGTTLWDPKIMEAYEKAELEALEEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH53</accession>
    <name>A0A1C1CH53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">sterol 14alpha-demethylase</fullName>
            <ecNumber evidence="10">1.14.14.154</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">CYP51</name>
        <name evidence="25" type="ORF">CLCR_03480</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>32-hydroxyeburicol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxoeburicol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75431"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:194328"/>
            <dbReference type="ChEBI" id="CHEBI:194329"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:75432"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>32-hydroxylanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxolanosterol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75107"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:75108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>32-oxoeburicol + reduced [NADPH--hemoprotein reductase] + O2 = 14-demethyleburicol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75435"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:194329"/>
            <dbReference type="ChEBI" id="CHEBI:194330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:75436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>32-oxolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75111"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:75112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 14alpha-formyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a Delta(14) steroid + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:68068"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:68069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 14alpha-hydroxymethyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-formyl steroid + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68064"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:68065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 14alpha-methyl steroid + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = a Delta(14) steroid + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54028"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:54029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 14alpha-methyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-hydroxymethyl steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:68061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>eburicol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 14-demethyleburicol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75439"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:70315"/>
            <dbReference type="ChEBI" id="CHEBI:194330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:75440"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>eburicol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxyeburicol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75427"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:70315"/>
            <dbReference type="ChEBI" id="CHEBI:194328"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:75428"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:25286"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:25287"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>lanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxylanosterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75103"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:75104"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 23">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 24">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.154" evidence="10"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH53"/>
    <dbReference type="STRING" id="86049.A0A1C1CH53"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03480"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04508"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008398">
        <property type="term" value="F:sterol 14-demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 23 24" id="KW-0349">Heme</keyword>
    <keyword evidence="7 23 24" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 23 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 24" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 24" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="25" id="KW-0808">Transferase</keyword>
    <feature type="binding site" description="axial binding residue" evidence="23">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00052067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00052625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OCT47843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="520" mass="58407" checksum="082E58DDC9814F0B" modified="2016-11-02" version="1">MAIPVGKILTSLVSVISISIIANILKQLFYRDPHRPPVVWHWVPLIGSTVDYGQDPYRFFFRCRKLYGDVFTFGLLGMKVTVYLGAEGNNFILNGRLKDLNAEEVYGPLTVPVFGPGVVYDVDNARFMDQKRLLKEGFTSQSLRAYVPQFVSEVEQYIDSNTAFQGEGGICDISTVLSEMSLYAAAGSLQGREVRDAFDSSFATYYRHLDDGFAPVNFMFPWLPTPVNRRRDRAQKMMAKLYMDIIQKRRSTGNHENSNDMLWALMDARYKDGTQVSDEEIANLMIALLMGGQHNTAASGTWIMLHLAHRPHLIEELYQEQLHTLGEGAPTYETLQQLTLHNNVIKETLRLHSPIHSIMRKVIQPMQIPETDIVVPAGHILLAAPGVPARSDEFFPNAMTWDPHRWDKPSTGHDRDLQGEDETIDYGYGAVSSKAVYSPYLPFGAGRHRCVGETFAYAQLGAILATLVRLLQWDQVDPEAPVPATDYSVSPSQPRWESKTCAESLPLRKPGHLAPSCTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHQ9</accession>
    <name>A0A1C1CHQ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_04238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHQ9"/>
    <dbReference type="STRING" id="86049.A0A1C1CHQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04238"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08223"/>
    <dbReference type="eggNOG" id="ENOG502S3CY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="194"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="336" mass="36819" checksum="FF60F0E96F3C92EA" modified="2016-11-02" version="1">MNDPPHVLLFGAGSIGSVCLYQFQRAGCRVTAVCRSNYDAVKRDGFSLQSLRFGDVQFRPDIVVRSGEECATDTGYDFVFVTTKCFPGSKPSLSELIRPYVRGRPHTAIVLAQNGVAIEDEVAEAFPENPLLSCVVYLPAYQKEHGVIEYPEMLNLLEIGTFPANSPESHKAAAVRLADLVVAGGGNAEVHDNIHIARWSKILMNCSWNPICALALCSDGDFLNSAAPYAWELGWGVMKEIVELAQTIGIPNVDEQVAEQKAMIAKTRAATNAGRENSMVQDVKQGKLFEVEAIVGNTVRLGRQHNVNMPLTEMLYALAKARFDALVREKYTKVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI79</accession>
    <name>A0A1C1CI79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exocyst complex component Sec3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_03800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI79"/>
    <dbReference type="STRING" id="86049.A0A1C1CI79"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03800"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08375"/>
    <dbReference type="eggNOG" id="KOG2148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13315">
        <property type="entry name" value="PH_Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.90:FF:000003">
        <property type="entry name" value="Exocyst complex component Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="91"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="597"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1324"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1529" mass="170060" checksum="3BEAC123B8473342" modified="2016-11-02" version="1">MNQQPMYGGPRQATPLTNGAQPRQNGRPGEQQESNQSRAARFEDEKQRIIEACFSKRDPEGMQLESYITHVRVLEDASYPSSPPPPDSPPSNKKHRVILVAVRRSGKVRVHKARENPNGSFSIGKTWNLDELTAIISYSSLVPANPQQQMEKQWASNTGFTVSLGKPYFWAAATAKEKDFFIASLIKIYRKYTGGKVPELIGFAPQEVQQLAGVPPSQNTPTTATAFSPIIPNPTPPPPGQQRFSPPPVVPAFNNNRPQSPYAAAQPPPSRDGPRIDPHEQRQAFGRQEFRPPTREQARPPSSHVEERERGVGLPPRPIRRVPPPEESRNQPYAARLTQEDARMPSLADTLQPAPLRPSLSPKASQSSLERVEPSLEPQPLRPNGLGVTTAGNRDFSPRRAGPTPGQDLPRDVGRNEQYGGSRPSTATSDRRTPDPPPSLPPILPGHSALESELYPEQKKPTAPPARADLRPEQPGPASQSHSAFVTPQGTPGATKDEELQRKPDYFANEKPEVQGKQSQADVSVPPPIPVYAQVTTPEPEALQSANEPASPESANSPAPPKTEEEFRPGLGPMVKKKSGKDIANQFRKAALAAAAFQPRQGGAGARLKAMQDKLSNEPDGVTSVVPAPLKRGMSGDSARSGTPDIATPDKEKDQPGPKLPPKDAVPQVQIERTATSDSLPRTGTPAAKPIPAEADGENEETKAESPEKVRSASPQKRRRQRLEAEVEKHCTGLGIDPRLTDGEGADLDELMTQLGWEGKLAEDDHVDKYETDIHREIGRAQASGWLGHVEQQESKVLELATAFDKAIAECEELDGLLTLYAHELDTLHEDIEYIEAQGQGLQVQTANQKLLQASLNTLLKTLSISPSDLRALQSAPIDSYDGVTAIEGALALLYDAMLTIDPELGQNKLKRAASTANRLGLGKDPEARIDKMRAVREKKDEYKDGSMMFVNRINQHMKMMFSLVEQRTSEENASASVSSGTSSFTLNLRAYNASRQELWVYNAMMLFVREVNQYEWQVLISSYERNFNSIYQEQFRDFAENLKRTVRQPTGEEQELLFTHQERERPDESNLSTAARKLTVKGRKPVKASTLRQSFGGDRRDGKPDAWTIFDTVLEQQALAISEEQNFIVHFFHLNSQAAEDFVEVIRSQTPEQRKLPNLQAKLPYDPDRNMAKIVQNTTDGIYSFWPSLLQGLMEWVLRLDSMQGVGVLVSLEQCLSKYEETNQEFIARTVRTLHDRITGLFHKFVEEQVRAIEETKVKVKKRKGLISFMRVFPEFVAAVEEMIPPQSEHQDSLEVRFIVNDAYKKILKAMWESLNFIAKDNPAANAGGQRNSSAPSSGDPEDKEALNYHILLIENMAFFAETISTHNNVVLEEWVEKAGRDQLSHLTQYTDAVIRRPLGKWLDFLESTEALMNKGDGSNVAIIAKMPSHSRSTAKKMLGNHDAREIRKGVELLRKRVEKHFAADDGEVVGGGGGSGNRRALVERVFDECSVRYAHAWDRMKVIIEKVYDGNLEMDWRKDDVQALFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI98</accession>
    <name>A0A1C1CI98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">M protein repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_03797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI98"/>
    <dbReference type="STRING" id="86049.A0A1C1CI98"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03797"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08401"/>
    <dbReference type="eggNOG" id="ENOG502QQB7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2289094at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="379"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="918"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1420"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="738"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1429"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1474"/>
            <end position="1483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1550" mass="171272" checksum="97554935313BCEC2" modified="2016-11-02" version="1">MDKKDETTTVRPKTAQPATRPLTKTASPRLPTTSRPSRTSSATRPTVGSSLSKPPARPSTTSSTVRKPATTTTHRKRDSDSTVDEKPSGDEKTKDGISAKPKRMSLAASTASDRASTTTKSVAATPARRTSIQPSTTATKPTTARTRPPVPSSRPTGAASVGERKRLSTIPASPVVKSGAESDDNKENTTSNTERMTVPVRPALGSRKSTRSVLIEQRIREFELVNSMLQAAMTADGADEQEQHSMDQEAATTIAKLKSDLAKVRDYERKHGRVPTTAELEEIQSVAGESIPEPQDDADARLVEEVQDASVTELQKDLAESRAQAEALQTELMELKAKLEVSTQSAAEESGRVQEAAEAVRKEHTAKIDELRSLHETRVQELENAHRERLQKLSDGHESEKGQLSQELAASQDAAAQLKLDLEELRKTAAERASAADSYSEMKNTLETKIGSLEVQLKSQSAESQRRMDQVETEIATKQKEITQKQEELAKVNKELSRQKQVIQSLKDQVSSFEQAKKEADDAQTRTINQLEEQIKTLQQEKADAAATAAASLAKAEKTQAERLEAIKRQLSDAQDQLKKAQDSGDTKLQDILKKSEADIAAANAELEAAKRSNSSRIQDLEAQLQKIQDEAVTKATEHERALAGLQSQLDAAKSALLEATSNHETILKDHEARSKSAEEELAALKASHEKELADIHAGIQSKHEEEITALQAAHAKEVADLQSKLQSKNDEELDALKNGHGEQIRQLEEKLQASQKEVSSLKKTHAAQIKQLEDQMNASLKDLGVIEAGHFEQVDRIKAEAAESQQRAVEEAEKVHIERVRDLEQQLHAAQADIAELRASHSSQLEDLERQRTSEHEAALGSLKESHAAAIQGLEDQLKLSDDSMETVKAEHAEQLKLVEDEISARHAETINALKEEHAKQLQDMESKAKSSQEEALEELRSSLAEEKRQLESQLNSIQQDLQGARAQTQMMKSIIQDTEKDSREKEERLNDEIEKLRTDMSTSVMKLARMSEIQFQHDQVVAAKTALEAKVQEDLDALRAEHEKSLAELQASLEQQHQRAVEQMQEDHAKNIESSRSAAELEVEGLETKLKENHDAQLDEVMKTLESQWKSQVDQLEEQNAAASSRLSKAQTDHEQAVQKLELEHDAALGKLLAELQDVREAAEAGQSSTELDLLRTQLAQAHEQAQKLEMKLAGADQERESTLATLKQQLAEAETLATQHLERAKELEQKQHEAVDLAIEENASALAALRKELDAAKEAHAQQLERTKELEEQHSKAMVAAIEERESALAIMKRELEAAKEAAAHLDPSQLEELNRKYLDAQHELSALQAKHEQAIREARADYEVQLETALTRLHAMEKANEKEPDSKDADAPNASLADANKTISSLQVELEGAMLEIETQRTLAETAQKELEQLKTQAIALPSPKPRRKSKSPKRKSMNALSPATSKPGLESSKWANPVEDAPALRGGSGEDDNDEDDTTTTTDKKPRNVAGQLAGIHEQIRQLDEMSEDFLEDHQKMASILSRVDDKTQYVSVDFEGEEGLEKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIG7</accession>
    <name>A0A1C1CIG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_03802</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIG7"/>
    <dbReference type="STRING" id="86049.A0A1C1CIG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03802"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08369"/>
    <dbReference type="eggNOG" id="KOG1998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="8">
        <location>
            <begin position="512"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1317"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1424"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1355"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1424"/>
            <end position="1433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT48221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1452" mass="162861" checksum="AE6A518A54999ECA" modified="2016-11-02" version="1">MPWQPLPLSYAVAIYPFQPSASPSELPLQIGDQLYVIEQGGKDGAWCRGYLVAPPTMLSALTPSGRTAGDARVFSGIFPKCCIEIREQLGPDVETLVQPGQPKPSAPVPMLKIGDESPTSTTEPLVDEITSCLREWYILHLPDLVLRRRYHVLNHMSEITTRLDYARRELLNDVLTTQERIQVRHDAVWDLVRGNKMLSGEVIVRDPARQGRLMTSQDSAIELAKLQSVMSVLNATPIEKPKATSLHHCLLEVRSIAGSGTDAASVNLALYQRNIEGNLKPFSETYSATANSNMKTLFSDLSNHDIGTDGRLYLVVKIVVSEPPRKPKRSVSTRPPSRNGTLLGQRQLSLNRRRSSLMFGKKRNAERPQPAQNGRTTPQSQDRSSTPSIIEEEEDGQTKPAGPPVPRTVGVGVLDIASIMRERQPCEESVTIWSLSQRDDEKGAESHPVEAQLLDSSGKALVVSGQISNVNLTLTPYTAPDADTLIKNTPTSMHMVTKTQKIGFSEAPTKPRSDIYLTLSRAVLAQGSFLSHPEVNVAPIKAHSPQNLQLTMEVRDNAGRRVEHCIFPSSNGAGVTAFRTNAVELDHRWDQTLCLRVPTEKVPESHLVLSIADAPEFPFALAWLPLWDKQAFVSDGRHSLILHAYDKITSSIVQGRGAYLSLAWNNASYKTIHEGALATIASLEVFTHLCSTEYSQDRSLVSLINWKHQTSVQLLDILQKLTFVPEIEIVKQLKEVLDALFGVLVHKSGESKFEDLIFNDIVWVLGIVHDRRFNLGPLIEQYTENHFRFPYAASCLIRSFTRLLQSVSDPQSARDMRALFKVGKNFMRILIISYQQRRFGSQQRDGDEKHSNFKEDMQAILFGLQMMMRSETAALVGSKTLLVQKFHDWLPELLPAFSKEEVLNIAVDFMDACEGATGKLLLYRIILILNYTKLDQIWVDEKDRKVLVKSCIRWLTPFWTPNNETEDWHEQVRLCCSVVAELTRFPTHHLHDFMPKLISAYKAIAEQAPARRRSLSLLFPDSYPFTTKSSDANDQFDETLLELSSLISTIAKIKQSSTLKLQGPDLSNYIISTLAVLRSLLGNDAFPTTWLSLHIYHHSSALTILNHLSTLLVSSYLPTPEDADSFDMRLWKSFLDTLLTLVSSPALTLELFPEQKRRAVWKIAGDVRQSGADLLRRAWESLGWEATADDQRRYNIRKLGGYQVQYVPSLVAPTISLCLSMHEGLRKVAVEVLQTMIVSEWALSEDLELIETEIIGALNSVLKAKPATANEALSRKIFITELLELFSTIANQPDDALWTALEELVGTIEELVDLLTGTDPDEDQMARNLTDTTNHKGHDSHKHQRTASKESQNSEAKELARARRSIDGLSPSSQQQRQQHGREREYGVHALECYKQLAEEYERSGDYKRLAKTHRAIARIHEARAASRMRGREVVNGSRQAGRDEDGEDDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJA5</accession>
    <name>A0A1C1CJA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04269"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10245"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="284" mass="32488" checksum="61828E595C3B8C3F" modified="2016-11-02" version="1">MSRREDMSIHSLQDAPRKSSSMPPWFQLPPEIRNRVCEYAFGGLVFRPRQPPGWDTNAETAHQLPLPSPSFMSLAVSRRWRTEVAPYLLPAATFDFTAHPGDPPCLVPEKAYEAMRHVVILETHCFSTEWLCQVLDKMLEVQTITIRKLRRVGTVDASAFDGTGLSPKFIDKVQTDPIKTLLGGYRFDHQYTRNILKSKWPQRRLFLEGSLWPGPDGPAHSHFQVDLDTWKVRIEGLLPGAKPYEIQATEPAPVGRAYFEDEEDMFGYLMSQHWASLQHGHDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJJ4</accession>
    <name>A0A1C1CJJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinetochore protein fta7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJJ4"/>
    <dbReference type="STRING" id="86049.A0A1C1CJJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04932"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03195"/>
    <dbReference type="OrthoDB" id="2420947at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025212">
        <property type="entry name" value="CAD_CENP-Q"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13094">
        <property type="entry name" value="CENP-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="38399" checksum="89EAA189DC6EA654" modified="2016-11-02" version="1">MGASKPAARTTKQGHTHLQSHSHSHSNASAHTHTRPTLEPRIKHIPQATIRKKWKPLPQSSQDKIHSILLNLKTKRSGGGGPNTRIPQVGKSRARDSSRPDAPPRAGATASKTAIAEAEYAKIVEDVASRLLSRLPRMPFPPTLSGGRGSSNHRNGNGADDFDLSSTLARISTLQAQLTCNMQAARLLGRQVGREKAALKLDKKELKTLEDGLRGSRELRRRKERGLHPLAREGGDGDGDKQTERENAAIMGIKGSGAAEVRRLLALALTAATTAAESTESTVSSESALGVEGTADPVDPDMSALLGQLRSHLQSMRNNTASLLPVVDAVDEAKVALEKFAARNLDEAAIRRLYGAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJK3</accession>
    <name>A0A1C1CJK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Versicolorin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">stcU</name>
        <name evidence="4" type="ORF">CLCR_04266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJK3"/>
    <dbReference type="STRING" id="86049.A0A1C1CJK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04266"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10232"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="264" mass="28076" checksum="4C2B39CDCAE553EB" modified="2016-11-02" version="1">MAQKPQTLDGKVALVTGSSKGIGAAVAIELASRGALVVTNYPFASLKPEAESTLAKIRATGGSHANEAFAIESDLATLEGPTHLVEEAVKRINGRKIDILVNNAGRASPQFLKDVTIDQWEFQVHLNGRGTLLTTQAALPHLAKPSRIVNLSSGGARQPYPGTSIYNGTKSMIESFTRCWAVELGREYECTVNAVAPGATNTDAFNALTGDTRDSLEPMLAMTPAASRIGETEEIAYAVAFFCEERARWITGQVLQVNGGTLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJP2</accession>
    <name>A0A1C1CJP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJP2"/>
    <dbReference type="STRING" id="86049.A0A1C1CJP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04795"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03241"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="2">
        <location>
            <begin position="310"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="532" mass="57354" checksum="DCD6A703E15ADE0F" modified="2016-11-02" version="1">MATLSSPLQTPNTASAQGELPNRKKAGARPKPQARHAPPTHFLCFPLVTDESVRQLTESLAYFRSVTTPLSEQDPDATPEPEDQTQQGTTAKSAEPDGERQKLRLLPESAHRPPGTYHLTLGTMNLSKQEDMDKAVALLQQIDYLALLKDAESGDGIVRQAKARARAKNAETKGETESVLEKRHDGGEGDGPPRRQNGEATILSNTETSESANTLSHPGSSKESASTLSHTESSKESANTSSHSESSEVSQYKLLANTYPTKGGPPSSSSSSSSSSQQPRPLKSLTRPISPPPLTTSSTSTTTSPSSAVPPLSISLHSLGVFPKPTGARVFFAHPHDPSNRLQRFGQPIRRRFRDAGLITETRPLVLHATVANLIYARGQDRRGGGGGGGKGKSSAKGKPRARDGTVDATEVLRFFNGDDNRGRSARQGDHMGAMSESIALDTSAQKSTQEPQRPEAASRATLHVQSDHERDHDHDHDHNHDHNLSSPYVWARDIPITCVRICKMGAEPSVLPGWGLEYRAVAEMVFMPDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJQ6</accession>
    <name>A0A1C1CJQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MAL2</name>
        <name evidence="6" type="ORF">CLCR_04736</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJQ6"/>
    <dbReference type="STRING" id="86049.A0A1C1CJQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04736"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03223"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="21"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT48672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="586" mass="67538" checksum="53F4513B4BA5806F" modified="2016-11-02" version="1">MIEILRQQHDRKWWKEAVVYQIYPASFKDSNGDGVGDIPGIISKLDYLRGLGVDVIWVCPHYKSPQVDMGYDIQDYEDIHERYGTLEQTEELIRAVHGRGMRIIFDLVINHTSNLHSWFQESRSSKTNPKSDWYIWRPAKCGKDGKRCRPNNWRSNFSKPAWTWDEQRQEYYLHLYAPEQPDLNWENPECRQAIYQSSIKFWLDKGIDGFRIDTVNLYSKHPDLPDAPVVYPDLESQPAYMYYANGPRMQEYLSEMNDIFAQYDVMTVGELPYTPNQADVMAYIYARNKQLNMVFNFDVVDLGQTPGNRFLPRPFAKGDFKRELFKWQSVIENTDAWTTVFLENHDQGRSVSRFGSDLPEHRGPAAKMLAVLLATLTGTLFIYQGQEIGMINVPRSWPAEEYKCIKSVSHLAEVREKTNHDPKAMSEALDILQMMARDNARVPMQWEGEAANAGFCPDDVKPWMSVLESHKQINVKEQVGHKGSVLEFWKEMLRLRKSHKDIFVYGRFREIESSGADDELAIFVKEGDNGKKALTVANLSKEEKKVTVSSVLADEGADLSLAVANVDDVVVDRLQPFEARVYISAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJS3</accession>
    <name>A0A1C1CJS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_05104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05104"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03136"/>
    <dbReference type="OrthoDB" id="5350391at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650899" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="144"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="264" mass="27080" checksum="8E441DA3529E6532" modified="2016-11-02" version="1">MQLVKTLSVMALATGAVVAMPAAHHKREWRGGGNRWWQRPNPNSVVTVTAYDAQPTDWNAAPSPSSTSTSTTTTAEVVVSATPTFGGNFFNRPTPEESAPTPAEAPEETSAPAGSWAPAAPAATPTSAPTDTGASGGQGDYMAVVSKMRAAGGLPSFTQDSKLEANALKTSTESTNGLQHQLNPGTFAQVLAPGSVDNFESVYVGGWLCEIPSLPGLNGICSSAAKGWDHSNGETGHADVLSSTKYSKIGCAISGTGVWACDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJX2</accession>
    <name>A0A1C1CJX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJX2"/>
    <dbReference type="STRING" id="86049.A0A1C1CJX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04993"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03108"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="350" mass="38478" checksum="4A8C6DC1B1EDC7F7" modified="2016-11-02" version="1">MPREGTSLPLKSHSFNVFGQEHLEESPQIDKISEDVNKLKVRPIPTLSIDDTTKAEDLIEGGPGKASLSHTSTATDEAMSRMETIAEIEQLDPDKLPPFRSLRPHAYTTDEAGHKGHAHDPLEDKLYLFIGPSTFSGTSSMTDDDGSFVPGGDGAPIVSESPGAADVDIYETAYRDEIERIMARAKEEQKEPNVYLTRRVDAKLMAISGLAGKWAAKGEEAKNQIKDYTQFSARKARVTEVSRALRQAAREEYERRRQEHREWIAAEKADRTKAKEEDVSRPTSSASPPSLGAGSDVEEPAGDSPQSPGRHSTMWKGKAVDAGRQARSSLMGFVDLVKSKSRTRSKDEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK51</accession>
    <name>A0A1C1CK51_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Maltose permease MAL61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MAL61</name>
        <name evidence="11" type="ORF">CLCR_04720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK51"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04720"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03011"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF56">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="49"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT48898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="563" mass="62820" checksum="06D99B68014AD583" modified="2016-11-02" version="1">MSEKAVEENVTSPEISGAAPGHHDNTGRRKSLDNVILNAQRATEKEHKMSLWQGIKLYPKAVGWSILISTCICMEGKYGEQLPDGSYQIPAPWQAGLSNGANVGEIIGLFINGIVSERFGYRYTVMVCLTLIIIFTAVFFTAQNVETLQVAEILCGIPWGVFQTLTITYASEVCPVALRGYLTTYVNFCWGLGQVVGIGVIKSMLPRDDQWSYRIPYALQWMWPVPLLVGIFLAPESPWWLVRKGRIQDAKKALLRLTSLNRETDFDADETIAMMVHTTALEEKITRGATYWDCFKGTDLRRTEIVCMVWAIQNLSGNSFSGYSTYFLEQAGLATSKSYDFALGQYGINMGGVFGAWFLMTLGVGRRSLYLYGLCGLCIMLFLMGFLGLVPDAHRDSAALATGSIMLVWALCYQLTVGTVCYSLVAELSTRRLQIKTVVLGRNLYNVVGIICSVLTPYMLNPGEWDWGNYAGFFWAAICFCCIIYTYFRLPEPAGRSFAELDLLFERGVSARKFATTKVDVFDATVVHETVEGTGTLKNYEEKRTGVLYPRAGEEDMPPRQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKK0</accession>
    <name>A0A1C1CKK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transporter mfc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_04758</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKK0"/>
    <dbReference type="STRING" id="86049.A0A1C1CKK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04758"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02902"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5403280at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF52">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="64"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT49009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="562" mass="60717" checksum="F3A09BE38F73B988" modified="2016-11-02" version="1">MTAFDYEPKEGIPIQDDAPTTVTTTTSSSSSGDDNTFADPDVIEWLPDDPENPYNWSASKKWTITAVGIMATFTTILNGTMITVAHAAINDEFHVSDDEFPNSYWPVTSWALGGALSGLVILPLMEDFGVRPAFLTTYVVFILFIIPQAVAKNFATLIVSRFFSGGCVSVLSNTAAALIGNIWEGDRARTIPMSLFVTLYLAGSSMGPVIAGIIFQTLGWRWISYMQIIWYAALFPIYVFFFQESRGTIILHRRAVKRRREEGHGHGHTSSGTHATTTTTTTLGPPKTSASLARKLARSTQRPLRMLFTEPVLFTFTLWSAFMVGTVYLFTQSVEQVFSSLYAWTASQAGYVQSAIVVGECVGWTGVLVSARLYFNSASRNVEVPGTPVPEARLYVSVVGSFVGVAGGMFVYGWTAWPSVPWIAPAIGLAMVGYGVEVVVLAIADYVVDAYAMYAGSAVAAVVLGENLFSAFLPLAAQAMYSRLGPRWASSLLGFLALGLSFAPVAILLWGSRLRQRSPFMKEAMVEKRRNVQAPTQSVPVPVQIARVSSNGGAGAGGVGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLC3</accession>
    <name>A0A1C1CLC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLC3"/>
    <dbReference type="STRING" id="86049.A0A1C1CLC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04728"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02652"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="86"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="550" mass="61094" checksum="6353C13AA242C70D" modified="2016-11-02" version="1">MAQHFHIAQITPHKPNKESSSPSTILQLAQRLLPSSAAIKELEDGLNPKDPGHSNVHEVVSPDKQEPSTAGGLPTQKKVIVVGAGIAGLRAASVLRTHGVQVVVLEARSDRIGGRIYTSRKAGRAPRDIGAAWMHETANNKLVRLIGELKIEHYYDDGTPLYYTKDGRLGSQFKAKKVADEFADFCEWYYDENPDAEDKPALTFIKEWLSTHPLVSEDERLWAPQAAREVEAWIGTSLEQASSKHLAYFATERNLYMKGGYDTIVNWAASNLRDPEIIRLGHKVTQIDWNEDERQPCTVHVTTLDGNSTTLVADAIVCTLPLGVLKHKLVDFSPSLPPQLSLGIDRLGYGALGKIFVEFESVFWPKDNDQFIYYPEPADTLDPDSILSYMTVTSNNWIMSGTTELSVQIVEPLTQRIESMTSNAEIFAFFEPLFKLFRTEPYKKLPPVVNLETTHWTQDPLAGFGTYTADKTGDDPEIWFNAIDSNKGSKLQFAGEHCARVGNGCVHGAFATGETAAVNIMTSMGISYNGGDLYSRRPSKRKINHTPPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLP1</accession>
    <name>A0A1C1CLP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum lectin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Protein OS-9 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">yos9</name>
        <name evidence="11" type="ORF">CLCR_04838</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
            <orientation evidence="1 7">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the OS-9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLP1"/>
    <dbReference type="STRING" id="86049.A0A1C1CLP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04838"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03357"/>
    <dbReference type="eggNOG" id="KOG3394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650943" description="Endoplasmic reticulum lectin" evidence="9">
        <location>
            <begin position="24"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="151"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT49445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="475" mass="52300" checksum="7328DAFC63E8851E" modified="2016-11-02" version="1">MGGLHVLGGVVLLLAALCRSSEAVFSVNDDLFAFPQYKIEFTDLYIPEADAISLLESKATNGPEAPQPLRSDVSSSINPDTHDGLVGEDAGQLGSYERLLLHGYPHLCFIPEAKPAAANGTAPEPSAEDRENELSRAVDRASQLLQGMASNQCLYYSTGWWTYSFCYNSQVTQFHALPPGTNGRVWPPQEDPTTPSYILGKFETPKPSDANTQPTSDNALSTEVKSKAETNYLVQRLTGGTPCDLTGNDRKIEVQFHCNPQLTDRIGWIKETATCAYMMIIYTPRLCNDVAFQPPKESRAHSITCREIVPENEIGDWQARRDAEKVIQQRIDQGQSQQIVLGGIEVGAMKLVGREGKRLERGRIVLTQDEKAETVIMQKNGQISGMSKAQLKKLDLSQEDIDAFQKELQKLAAGKDWKIERLDDVNGHIQLRGVVSNDDDEEEDENGAQQNAGDKGAPDEDNDATGSQEEYAKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLY1</accession>
    <name>A0A1C1CLY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLY1"/>
    <dbReference type="STRING" id="86049.A0A1C1CLY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06644"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09777"/>
    <dbReference type="eggNOG" id="ENOG502SHXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF79">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="146"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="768" mass="86825" checksum="0A661EF2D476A620" modified="2016-11-02" version="1">MRVRRGFNARELLSSLTSESRTYQYRPLPSARSIRLLEVHPLPPSSDGSGKIAVSLSTHYVDDAPPFQALSYTWGYPLIPESRPSRSSTWRRLAFLQRLQARSLLENDSRAGSVTGSSASLSPASSSGSHSSLLRIKLTQNMPCFPVKCDGRNLRVTANLHDALAMLARTHQHVHDEFPRKRNFYWVDALCIDQSSLTERNTQVSLMSDIFRTAQGVTVWLGEEDEFTPDAFTVIERIASIPRAKWADMSYTGFFDPEGSCYHGTGVEPLTYRNWLGFIAFTNRPWFSRSWVVQELALARNVSVVCGSRTLPWEKLARTIEFIRATRWYHHLSTEKMRHLRELNRCRGAYQKFLASNTNFGLEPVYLNSTRNALQAYEKGGNRGAPSLRMLIDTHRHTNATDPRDKVYAFLGLASRTSSSTNQIEPNYETSTRQVYIDAACSLLRTYGNLYLLSHVQDRSLTKTKGLPSWVPDYSVPLSPYPLDFRGRCNWSACGNMKWMPPKDVRTLDRGLLPVQGFHIDTISETAIMPYEATDAGEPWASIVNMVSNLPNPYPLPSLKGAPISRIDVLWRTLTTNTYARQHPAPPECGALFIDYVLNLQIRHRLRPWSSNDSEFQPHSTPLSVLTNPDWRSLIESEPNDSPYNISVYRRRLTALVENMLSSNSYTPIDLAQLHHDIENGSGRMRRLFRTSGMMLLGTGPRALRVGDEVWILGGGRVPYILQPVTVREGTGTSPQRQHRLVGEAYVHGLMHGDPARFGRDLQSTVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLY3</accession>
    <name>A0A1C1CLY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLY3"/>
    <dbReference type="STRING" id="86049.A0A1C1CLY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07380"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09769"/>
    <dbReference type="eggNOG" id="ENOG502RA6W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="15"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="344" mass="38917" checksum="EB9070F02AB2F43B" modified="2016-11-02" version="1">MWDLLSQPGLPPVRAIWAMDIASSGQSFLLNQDEIGDEPHWYDAARDITQMVNHFQAEMRPPLVGIGQSWGGAVLTVAAAFNPRLFQGLILIEPILENGWYHVHASLENKGEILVTGLGAAAPSLARRKRHYASRAALTESVQRAKMWDAYDPRVLQQILRYDYRDLEVGRVELITPPVQTVSYFWRPSPPLSGFPENEDYATRDEDANWPPGFYAAQGAVAKKALATLNCPLLFLWEKRGSFVSDEGYRQRVLASADALGRRKNQIEQIFVDSGHSLALFAPRKTAEAAATWIEKFWHHWLDEERRRQSDAPVDAQNVPPEFVERTQRVDAATADYVKRKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMQ5</accession>
    <name>A0A1C1CMQ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07594"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08710"/>
    <dbReference type="eggNOG" id="ENOG502SUSI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="504210at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25371" checksum="5860C94921D49C12" modified="2016-11-02" version="1">MRRQTVHLKIFERQGPEAVIYDLSDADCVTITLPAASRWTSQLHWHETHTEFLQVLQGRAFVRLGDRAGIHGPEDGVIEVPKYTVHEWHRAADGDRSDLIVREWTMPGDGQKEVFFRNLNSFLTEPQPSSLYDKPSVIPTWGARWLESWIIPLQLCCIFRSWDNWPVLIGDDSRLVIWPATHLVLGFCSSVGFVLGLRGTYDEYVDKALLLRAGTGSGGKKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMR6</accession>
    <name>A0A1C1CMR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMR6"/>
    <dbReference type="STRING" id="86049.A0A1C1CMR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07477"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02409"/>
    <dbReference type="OrthoDB" id="4160321at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="286" mass="30996" checksum="436D9C271B544160" modified="2016-11-02" version="1">MLEHGADVNAIGQHGSLFERAFQARNHDLVHYLLERGARPEVPLDIYNRTSIRMAVDRGIFELAKLLIEHCARANLLLPDDGVDALAVACRTSDVPMATMLVGYGADVNTPSSDGLTPLQVACWKKSVEIVKVLVEAGADVNARFSNRRTPLQNACLYENVEVVKVLLEAGADVNARFSNGRTPLQDACWYKNVEVVKVLVEAGADVNARFSNGRTPLQDACWDGNVEVVKVLVEAGADVNARFSNGRTPLQDACWDGNVEIVKVLVEAGADVHAKGHLEPGFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN20</accession>
    <name>A0A1C1CN20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PRO41 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN20"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07653"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08765"/>
    <dbReference type="eggNOG" id="ENOG502S16N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2110422at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056144">
        <property type="entry name" value="DUF7727"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629:SF1">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24853">
        <property type="entry name" value="DUF7727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7727" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="164" mass="18505" checksum="7F5E374D5C8D629C" modified="2016-11-02" version="1">MGKLIKNHWGRLIVLTAALYQVMAALEGFFWPKIFFDFLTKNLDGAVKPFPVLQIMNLVLGLLGLAWEWPLAPIVKMLPGLHRSMEARLVVYPLSALAAVLMYQSTNAALYYIVGVVVYFWAYSEGENLGLYRRGEVPDLAKYELFTSCAADHFPSVLAFEQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNE5</accession>
    <name>A0A1C1CNE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_07251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNE5"/>
    <dbReference type="STRING" id="86049.A0A1C1CNE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07251"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08944"/>
    <dbReference type="eggNOG" id="ENOG502RM4B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650929" evidence="4">
        <location>
            <begin position="19"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="407" mass="44139" checksum="9367F82A08F7C725" modified="2016-11-02" version="1">MHLQLLVPALLALSAAHAAPAPADSGFSERDASVSAASSAFWLPASTVQTDILAAKGLVNLAFYELTNPPSGGCNLLNAAIRREWSTLSKDERKAYIAAELCLQSKPTKDPSFAPGARSRYDDFVAVHINSTLFIHGTANFLAWHRYFTWAFEQALRNECGYTGYQPYWNWGKYAFDPLHSPLFDGSDSSMSGNGQYAPHGPTNALPTGLNPIPPGQGGGCVNTGPFANYVVNLGPVAPTLDVPGIIDYSSPDPLAYNPRCLRRDISSWVSSNWTKDADSFDLMSNYNDILSFQNRMQGDFGSGFYGVHTAGHFTTGGDPGGDLFASPAEPTFFLHHAQIDRTWWIWQNQDPKNRKSAFAGGTSTLDPVNSPPGKLTDPIIMGSLAPTIQNKDALWTTGGPFCYIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNT6</accession>
    <name>A0A1C1CNT6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingoid long-chain base transporter RSB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_11347</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNT6"/>
    <dbReference type="STRING" id="86049.A0A1C1CNT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11347"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09074"/>
    <dbReference type="eggNOG" id="ENOG502SHYP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22672" checksum="A46FC9048DF531B3" modified="2016-11-02" version="1">MEIVGYAFRLLASQKNPYAVSYFVAQYFCIVVAPVFFSAAVYTIISVMIGVVGRKYAPLSPRVILWVFIVCDVVATVVQITGAALVGRAYSDQEDPDTPNNILLAGLAFQVFSFAVFVLCFCVFVYRARKVMETGLCVFSAAVMVATVAVYLRTCFRLAETAEGLLEYLSTHEVFFGCLEFLPIVLAVYVLVWWHPGRWLVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNU1</accession>
    <name>A0A1C1CNU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tol-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNU1"/>
    <dbReference type="STRING" id="86049.A0A1C1CNU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06548"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09052"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4160359at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="197"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1307" mass="147410" checksum="69D5012BD79E537F" modified="2016-11-02" version="1">MNAVYGSESATNSPEESDNEEPAEKQLRGLLSEHMVMNPLDHKDFLPESSLKQLINRDRIRSCMPGAKEDLIEFVSDHAPRLFAIVVYIQEFGKELSSAMTRFRKHGLTDGHLPIPNINEKGVCSYNRSSPGREQHSRLTAVTQCSHDRALDALHHKQWKHDKIRQLYSDQWMFLSPVFTKEKFEHNLDPRIVLPFTRRGGGSGKGHFSEVREVYLRADHQRIFPTEENKEIRIAIKEITNIAGSVHEAEKVWKREARALEVISSLNHPHLIRRIAAISRAEKYYFLFEWADGGTLRDFWESESRPELTADRVREIVEQLHGLAKAVEALHKYVGNQNSPAPVSHIRDAREDHNGALPSKAPAITLNDADSLVESDEDDDQPSVTGHFRHGDLKPDNILRFNRHGSWLGTLQVADLGLAKQHRRDTIHRRQATTQKYGTIQYEPPEVVTDRFGPRSRLYDMWAMSCIILETIIWLLYGLDTLNKFLNTKIPTQSENTLYYTISGGRAEVSGLVTGLMKEILETDPECNASSGSALGDLIRLVADKLLLVDLPGPGGNPESPCRIDAEKLADALANIKRRSRDRTYLFTGSNRANVQVPRMLTAQEVPLAPTSHLSPRAAFQHRPSREPGVVQPIPITAVQGRCMCPPSNYGLMSELTKALSISKTQYLSQDDWEFVDDSRFALHVFKTLGDAYTSVFSGKASDLCSRCRELDFHSGISIREPLAALEASASSCDLCSMLLKAWKRCGDSGDTSATVEFRKVGSGLSVEHSRGQMPILSIRRGIGRGHGWTQPSSGLSRVPLGFSHLPTIGSLEYFHVLRQWLDDCNKYHSHCRRDPHNPKGTPTRLIDVGTDPHAPTVRLHETGKRTTTNEAEDLTYIALSHPWGDPAVHSHFCTTSHNLDQHRRAIAITALPRTFSDAVTVTRALGVRFLWIDSLCIIQNDRGDLQNEIERMEMVFSNAYCVIAASRASGMSDGFLNDRPTREVIRIDSKRDEGSSVFVCEAIDDFQGHVIEGALNKRGWVLQERALARRTIYFTAQQTYWECGCGVRCETLTRMHNNQADFLGDPNFPRVAMESPKGAKIRLYESLYKRYSRLEFTALEDKPVAIAGLEQRLIRVFDTHGGFGLFEQYLGRSLLWQRDAQVRTMTRIHFRTQVVPSWSWMAYEGGITFMDLPFKGVDWERKEIRSPWNHEPASGPTWLSTGRGSCTHLEAVARSFRLQSCGDGDQLSEPLYQIVFDQDEPPPGEHALKCVIVGRSKPVAGGDARRHYVLIVGQRSNRSRYERVGVGFMPGYWIVLDEPGFKVSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP03</accession>
    <name>A0A1C1CP03_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP03"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07769"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="88" mass="9176" checksum="EB1A60C0C4EAC50F" modified="2016-11-02" version="1">MQATPPLTPSPTKALTTILKDTAPFSLAAVCAESTAAASPRGSVSLAKRPCSAWSGAKYAGTRVDNQEPHAVSQPVCEGNLRRAKRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP21</accession>
    <name>A0A1C1CP21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sterol 3-beta-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_06570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP21"/>
    <dbReference type="STRING" id="86049.A0A1C1CP21"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06570"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05733"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05734"/>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="4">
        <location>
            <begin position="139"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="5">
        <location>
            <begin position="470"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="688"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="982"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1157"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1220"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="743"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="996"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1039"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1071"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1093"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1180"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1194"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1225"/>
            <end position="1237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1244" mass="136230" checksum="126E185D434B6A92" modified="2016-11-02" version="1">MGRRVPEALMQQSMLQQARAAAAAEANPARRTRRETLLQMTDLVTPGLAEDDVPPPPYGQIHGEIRNEKNGLGISTSVTDDGRINIRINQFNRRLSQVFNPALRQQIQSSQESRPPPSPYIPPSLGGEEGVPPPPPLNIVIQVVGSRGDVQPFVALGRVLKDTYGHRVRLATHLIFKDFVQEHGLEFFSIGGDPSRLMAFMVKNPSLMPGVRSLLSGDVGQRRRDVAEYIQGCWRSCYQAGDGTSLHTTNDDPSDPSGNDLSSEQAARPFVADCIIANPPSFAHIHCAEKLGIPLHIMFTMPYSPTQAFPHPLANIQSSNADPQLTNYISYAMIEVLSWQGLGDIINRFRARCLGLDAVSLIWAPGMLHRLKVPHTYCWSPTLIPKPKDWGSHISISGFYFLNSASDYTPAPDLQAFLDAGPPPVYIGFGSIVLDDPNAMSELIFEAVRKTGQRVLLSKGWGGIGADELRIPDQVFMLGNVPHDWLFKHVSCVVHHGGAGTTAAGITAGRPTVIVSFFGDQPFWGAVVARAGAGPDPIPYKQLTADKLAHAINFCLRHDSLERAKELASKIAEERGTDMGAQSFHQHLEADRLRCTLAPSRPAAWRIKRTQVRLSAFAACALANANLLDFHDLKLFRPQEYSTDEGPWDPISGFAAALFGAISSMAMGVADFPSETWKALQIPMVSSRQQYHGSMPTIAGKRETSPIGERSTPPTSPEQSQTSLNLQESFAHVRSPSNLSVLTTPTSNKGSSSTSSDALQGHLNSKQDGASRRRVRSRDESGFGKNNDMMRQTGVHTSKGFGRIAKAAVQAPMDLSMSITKGFHNVPKLWGDDTVRPQEQVSDFKSGVTAAGKEFGFGWYDGVTGLFTQPWKGAQKEGTSGFFRGIGKGIGGLATKPGAALFGIPGYMMKGVHKEVQKLFGSNVQNYIAASRTAQGYEEWLESSDVEKQDVIVRWKLIQKYLKKKSTPDEMVRDVLEAQRKKKIEDGDGRQNSGYTANSADTASADAPILDPESPMLATGGSRSSDESLEATEINRTIRLSDQESSGEKAERNANVEQAIRENASRLQRQQHGDADHQADQENLRQAMAASEAEARRHASEALEYEKQLKRAMAQSLREQRRRSSASVRESNIGLDDEGDEDFERVIRTPENMAAKAAAVVGGSPGDQQPSPHDLAHLEGTTQSESEAQQQKGQWEEKTTQERTEEQIVMEYVKKQSLLEMQHQNKANGRATATGTATKDKDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP82</accession>
    <name>A0A1C1CP82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP82"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06857"/>
    <dbReference type="OrthoDB" id="4161601at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="69972" checksum="21ACE42E25FE0057" modified="2016-11-02" version="1">MDILGTIDASISLARTIRDLVRTYEEAPGAASKLQFFDVQLGVIRLTLLRSALEKNPPKLQPNKNELLRALSTLDKKLRETSTDLEALDLSRLTTRFWWTMSAGTRVTNDFADIHRCIDDLQDIVQLVHLVPKIEPLNSHDGENFSIVDFGAIKRLKNSNFGYCAEAYWKASGALEVKRETVPVFVESFRKLDNGGELVVGVAQRLWWSCDGRNNTPYQMGVLPCIGFDKHRVIFLLPKNATDPQTLRELIRGQEGKGGRQGVSLETKFSLALQLAEAVLKIHMAAVVHSSIRSDTILFLAPDATRGTPELAATKGTERSENQVAAAGISPPNRVGTGLERLDTGLKRVRTGLKRIASGLTQKETLVQDPKAGAGDAQPTDREDATKAQKVPKRKDSQRSMRKGTIRRKTTRKHFGVFKSGQGSSSEGLSDDRKVENSAAENKDAATEYDDGTTPVVGAVPPGFGSLYLISWISIRHRGEFLPGFAKAWTRNLYRHPKVQQGSVQGNMGHDIYSMGVCLLEIGLWKSFVEVENNHYVPSQLAEKAGVSIDKGKNDATQIKTKLVEIAEEDLPAIMGDGYTRLVVACLTCLDGDGDPKPPVPTWKHSFTTLDRQKDVEAFQSVVLGVLSKINDGFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ13</accession>
    <name>A0A1C1CQ13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_07131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ13"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ13"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07131"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05435"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF236">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT50578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="450" mass="50418" checksum="970CCDFE4AEEBD69" modified="2016-11-02" version="1">MPEFFRLPPSGIKVIIVGAGFAGLCAAIECNRKGHDVILLEKVAQLKPLGDIISFSSNSGHIFERWEGVVEKLEPIIHHSDGLSFYDWKGTFATRQIWDVEKQWGRRINGHRGEIHLAVFEHAKARGIDIRLGQQISDYFETDTEAGVIVNGERLTADCVFAAEGVKSAGRKIVLGFEDRPKPSGYAVYRAWFSSDDLAKNERTKHLVNNGDSHTGWIGEDKHFLAAAIKDGKEFSWVLTHKDDADIDEDWQFPGNKEEVKRNLQGWDPAVHDIVDATPADRLVDYKLVFRDPLPTFISPKARIALIGDAAHPFLPTSIQGASQSMEDGVTLAITLEKSGKDDVPRAIRAYEAIRYERVHRAQMTGVTTREQWHKADWDKIWKDVKSLHLKRESWLLDFDAETHAYEVIDDVLKKLDRGASVKADAVSEPTPATANGVQGRIAQEIDQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQA3</accession>
    <name>A0A1C1CQA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQA3"/>
    <dbReference type="STRING" id="86049.A0A1C1CQA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07731"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05359"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650979" evidence="3">
        <location>
            <begin position="25"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="144" mass="15375" checksum="5D500A1417E412CB" modified="2016-11-02" version="1">MFYNNLLTIPILLVSSLVVEDWSAINIAKNFPIDARNAIIGAMIFTGLSSIFISYTSAWCVRATSSTTYSMVGALNKLPIAVSGLIFFDAPVTIPSVSAIFVGFVSGIVYALAKVRESSKPKTILPTSNTMSASSQSNRDSLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQH8</accession>
    <name>A0A1C1CQH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nuclear distribution protein RO10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07564"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05264"/>
    <dbReference type="eggNOG" id="ENOG502S5XV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5403729at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="215" mass="24138" checksum="3E6A4D4A0A7771C6" modified="2016-11-02" version="1">MTTHTDDPEAAARATLALLETRLHRVEFLLSGASNNDGVPPAIATPRSGSETLRARLEALEAGLAKLKRLAGTPGTVIRDIERLDLFAPTVPAHKDVKSEELSTLASIVLAHASLYPETASRLSSLQTLHVPPAEQSSELVSLVPRLRQLDREEQRLQDEARELRERSARCLEWWVKVGVVGMGDVWQDWEKRMADVERHVIRWERRAKEEQGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQU8</accession>
    <name>A0A1C1CQU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc-binding alcohol dehydrogenase domain-containing protein cipB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cipB</name>
        <name evidence="5" type="ORF">CLCR_08753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQU8"/>
    <dbReference type="STRING" id="86049.A0A1C1CQU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08753"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09487"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="15"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT50841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="371" mass="39616" checksum="7BBC035E7A438697" modified="2016-11-02" version="1">MAPSNRAAYLVAAKKRPLEVQSAAYTQPGPGQITIRTRAVATNPLDFIKQTVGDLLYDWVKYPIILGSDVAGDVVEVGKDVTRFKVGDRVVGHSIGMAKKHNSPALCGFQEYVNLLAHMSSRIPDSLPHENAAVIPLGLSTAACALFQKDQLALQFPSTPAAKSTGRTVLIWGGSTSVGVNAIQLATAAGYDVITTCSPRNFDLVKRLGAIAAFDYHTSTVVQDVKNAFQGRITAGAISIGQGAAGACMNILGSCKGDRVLSMATYPLDPMNLPKRFVMPIIAYTYLSGMASLWIKAKRYGVRSQFIFGDTLVDNEVGPMVYEQFLPKALADGSFVAAPEPEIVGHGLEKIQHALDVHMKGVSAKKPVVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR85</accession>
    <name>A0A1C1CR85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">alp4</name>
        <name evidence="9" type="ORF">CLCR_07999</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR85"/>
    <dbReference type="STRING" id="86049.A0A1C1CR85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07999"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09627"/>
    <dbReference type="eggNOG" id="KOG2001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000011">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="178"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="516"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="831"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="909" mass="103338" checksum="3740E809F34CDAAA" modified="2016-11-02" version="1">MTSLHYRSASATDRRSTQFSNGTTRVNSSRATRDERPFARDAGSPVLPDGNGDPGNGANVASNAEKRLSGLEHRRREKSTITTTESIYTRRSPKKEPSNTAARNGARRSVVSPVLKQPDEDASTPSPPWAPSVSLIPHSSAPLAVRVTVPPLSRHAPADLDPLPLDHLSMQEQEHALLDDLLYVFMGFEGQYVRFQDSYDPAEEKHRLNGPSFHPLPGLDPSLRDLTTSMLSMATHHCAIEAFIEVQSREEFGSVNHALCAAIRKLLKDYLILVAQLEMKVLTDPKFTLHQMHIAIIPTAQCLTQLYSLAQELLKKNSLLEEDIDDSIDDFDADNIIERLKEGGDLLPGSLAKKRCIGGNVLGLLTTRLSTFSGDPAARSILEMLLRESSRPYMVMLNEWLHHGGINDPHSEFLIGERASIKRERLDEDYTDEYWEKRYYIREKEVPPQLDAMREKVLLAGKYLNVVRECGGVNISSKIVDTPATFDDPRFLDNVNNAYSFANKELLHLLLTKNSLRSRLRSLKHYFFLDRAEFFLYFLELSDSELRKKHRDVNVGKLQSLLDLVLHQPGSIAVADPFKEDVKVEMNSVGLTQWLIKVVNVQGMDQDNPDSVIDQYKTPAASQMSATEKLKEEKKKEEEKDIIGFDALELDYQVPFPLSLIISRKTVKRYQLIFRYTLALRHLETQLVGCWSTHTKEKAWIHKSSDKKFELWKRRVWTLRSRMLVFVQQMLFFATAEVLEPNWQKLMKKVDDAERDDTDEMRPGLNPKAKPTVDELMQDHVDMLDSCMKDLGLTQAKLLRLHTKLMTGCGMFASYVEHVTKSIYDADTSIQLKPAKPGGATPPPPQPTDPVRMKRIEESIRKYEEHFNRHLKILIDALNWFATTETVSLLSLCGRLTNAEVQKRDDLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRD6</accession>
    <name>A0A1C1CRD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sialidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRD6"/>
    <dbReference type="STRING" id="86049.A0A1C1CRD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07989"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09703"/>
    <dbReference type="eggNOG" id="ENOG502QQCH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253390at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021829">
        <property type="entry name" value="DUF3419"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473">
        <property type="entry name" value="BTA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473:SF1">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11899">
        <property type="entry name" value="DUF3419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="809" mass="92309" checksum="48144A437DEA91AB" modified="2016-11-02" version="1">MAHFSYAEWQRLKGFHLELGLIGVGFTVLVTILGVVLYRLGGRIPIDKLTSNPYIRFVYACMLKPHERRSDGGQQGALESFYSTQANVYDSTRKRLLRGREDMLAILLAQLQGKLASGDGRKPVWYDIGGGTGYNIEVMDKLVGVEGFFEHVFLVDLSTSLCAVARERVHKNGWKNVTVLCQDARSVACNPGSADLITMSYSLSMIPDYYSVVDMITSFLSPKGLIGIVDFYVQSVVDYSSRNYCGGAFNRHVNWFGRMFWRTWFEADRVNLDGGRRDYVEYRFGTILSTSQRNYPLGGIPYYIFIGCRRDAEAFAEQGQEVLEKLDAALTESPYLSPMKFKERRNLDATHDIPRSKSYESAIVNLSNDLPLPSAFYQQHHWRIYYNDLLQKHQQFGNEYIYAFNWEDPKVDRQLLNINQDDVILTITSAGDNILDYLLEKPKRIHAVDLNPNQNHLLELKVAAFTALPYSDVWQIFGEGKHPDFRNLLLSKLSPHMSSQAFQYWLSKSYIFSSKGGLYESGGSRHAIKLVRWLFKTFGLTAKVRTLCKIETLNEQREIWPQIRTLLLSWPLHKTVVSTEWWAWKAAGVPPNQHALILDDYAQRTKLPKSKKLCGEAIWQYVVDTLDPVVETTQISRDNYFYYLCLQGKFSRKCHPRYLGVKAHAQLSKPDAFDGLRIHTDEIMEVIARISPSTLTIAILMDSMDWFDPNDADGAAVEQIVSLNKVLQIGGRVLFRSAALRPWYTDIFEKNGFEAKCVGRRDSGKCIDRVNMYASAWICTKKVNISDSPIIPSKRKDTVAAAALEELRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS68</accession>
    <name>A0A1C1CS68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09276"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="125" mass="14209" checksum="BD2E2C4D8198D3FB" modified="2016-11-02" version="1">MWLQELSPHHGCLMLNVRIEELNLDLFLGIYVELIPCPRVHRQFFFYQFIETQSRESAMPITIQATQLAEYYPEPAGTYGLWADNLRNAFGGHGNPTATGRRLRGNQSTVVAYLLPNCPKNPGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS89</accession>
    <name>A0A1C1CS89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylethanolamine-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS89"/>
    <dbReference type="STRING" id="86049.A0A1C1CS89"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08825"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06735"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651011" description="Phosphatidylethanolamine-binding protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="32921" checksum="639F98A5B539940B" modified="2016-11-02" version="1">MNHFRSLAVLALAALVSAQSAPGFPIQVDTNLRADFQDTSTSVSPAGVLLNRDDVLEEPTIVGPSDSTRTIDYMVFMVDQDVTSPTDPSTRIQFLHWYQPNLAGASEVLFDFDSDSQNFTSATPLAYIPPTPPGGDIAHRYTIIMYRQPEGFNIPSGFESFFEEKSDLSNRLDFDIAGFVSASGLGEPVGANWFQVQNRTESASNSSSSTTTSTEASSTASQTNATTTVAGTETEATPTSEPTASVESTTTAAVEASTSTAVVTASQTPETGASSAPSASATSSSPAPAGAGTVASNGSGLVLSFVLSVAGAGWWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS90</accession>
    <name>A0A1C1CS90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome b-c1 complex subunit 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS90"/>
    <dbReference type="STRING" id="86049.A0A1C1CS90"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09247"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06722"/>
    <dbReference type="eggNOG" id="ENOG502SBV5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2391627at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="111" mass="12302" checksum="C55833849C5DBA85" modified="2016-11-02" version="1">MIPSRALRLPAFETGYGSGRTPLRVYKPQPTYETYISPYGPKTKHIPNLMGITPGKALRLGYIASGFGVAAGIFAVFFFGEVPRVREDILSKLPVIGSYWVREVPPEDNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSD4</accession>
    <name>A0A1C1CSD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquinone biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSD4"/>
    <dbReference type="STRING" id="86049.A0A1C1CSD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08152"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06681"/>
    <dbReference type="eggNOG" id="KOG1236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1290869at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13971">
        <property type="entry name" value="ADCK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044095">
        <property type="entry name" value="ADCK2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="208"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="300"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="695" mass="78818" checksum="7EEAF1F88496D41A" modified="2016-11-02" version="1">MRTFFVFGRFCGRREFPSSFSRFAFRVRIPRHQQSFARWTRKYSLKDPRQRRTPTLLAAAAAATAISPAAFVQLGENHDGEKTGEMYMLEMSRQEISKEVPEDARGIRRFYKTVIYVLDQWVYEPIATSFRFLHLLLIFVPVIVTIPAAFLGPRRKDHDDERIGTIWWYGFLVKSMERAGPAFIKLGQWAASRSDIFPAEMCRQMSELHSNAPAHPLRHTIKTISEAFGGRTFDEIFEEFDEKPLGVGAIAQVYKARLKPDLARLDNSELEASDNLRLSHRIKKNVDALVKSTPQRVPSAYVAIKVLHPKVERIVRRDLKIMAVFAAVINAIPTLEWLDLPNEVYNFGGMMRLQLDLRIEAANLTILRKHFQRRTTAWFPCPYTDFTTRNVLVEEFAQGIPLAAFLESGGGVFQKDIANEGLDAFLHMLLIDNFVHADLHPGNIMVNFYKPTHPELPSYLSRQDASQPSTASEIDASEAVLSRLRPHIGKKKEWQAALAEIEKDGYIPQLIFIDTGLVTELNAKNRTNFLDLFRSIAEFDGYRAGHLMIERCRQPDAVVDGEVFALKMQHLVLAVKGQTFALGNIKIGDVLSEVLGMVRSHHVRMEGDFVNVVISILLLEGIGRTLDPDLDLFKSALPILRQLGSSDPGAVLKSFREGDFSLLKIWVGLEARRFFQASAESVEMCVKYDLLSPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSD5</accession>
    <name>A0A1C1CSD5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">gad8</name>
        <name evidence="14" type="ORF">CLCR_08154</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSD5"/>
    <dbReference type="STRING" id="86049.A0A1C1CSD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08154"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06669"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="295"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="553"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT51413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="637" mass="70541" checksum="CFDCA14662B1002C" modified="2016-11-02" version="1">MSWKLTKKLKETHLAPLISGSSRSTSTSTVKAEDSSPAQETPELSTIHSNTSTTSANGIAASEQLTSPPVQTTKPGILIVTLHEGKGFSLPQQYQSVFNNHYGSGQSGSVRPSSSYAAGSMAGSYAPSNRPVSTHAGINAAPTIHGRYSSKYLPYALLDFDKLQVFVDAVSGTPENPLWAGDNTSFKFDVSRVCELSVQLYLRNPAARPGVGRSEDIFLGGARVTPRFEEARQFVSDPKKSKKDNEKAEAAFNAQEKQAGQLGAEWVDIQFGTGSIKVGVNYVENRQGSLKIDDFELLKVVGRGSFGKVMQVMKKDTGRIYALKTIRKAHIISRSEVAHTLAERSVLAQINNPFITPLKFSFQSPDKLYFVLAFVNGGELFHHLQKEQRFDINRSRFYTAELLCALECLHGFKVIYRDLKPENILLDYTGHIALCDFGLCKLDMKDEDRTNTFCGTPEYLAPELLLGHGYTKTVDWWTLGVLLYEMLTGLPPFYDENTNEMYRKILQEPLHFPGPEIVPAAAKDLLQKLLDRNPERRLGAGGAAEIKAHHFFAGIDWRKLLQRKYEPSFKPNVVDARDTANFDKEFTSEVPKDSYVEGPVLSQTMQQQFAGWSYNRPVAGLGDAGGSVRDPSFGSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSI7</accession>
    <name>A0A1C1CSI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSI7"/>
    <dbReference type="STRING" id="86049.A0A1C1CSI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08076"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06634"/>
    <dbReference type="eggNOG" id="ENOG502RZNG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="777" mass="86618" checksum="DD1F4A5F7882862B" modified="2016-11-02" version="1">MYKARLSQWGISKNYSDKDYQICSVLNHHRQKSGKRSTAFMIHGHKRSLKDLHKYVKGRKMTEEDFLASALANVDCHGGDQQQQPEQYAHVRAYTPEPEVEGDDTPSAPARVRPAEIVANVDLSLNANISAAAFAPTGTAPDSGASGPAMCSTAPTSTSTSMSIAAGPSSAFTTIHHGSPVSQQKTRSPRARASPGMPLTLANQVTPSTQQQQQQQHPRQGSRFPPQESTVTWPPPSNSPHSSRGGYFVSSPQGTPSSYTFSTTHEAAVPFEDQVRHAGGFDYDSSSPTMPCQRLGRDVEFMALQIIDAPPLRSLCGHDDIRAWSLMMADSTSSTSSASSDGDGMDYEQICPTCHESTREHFISLPNLEMAPAPARNILNVTHDVAEPPPAMAMALPASSRGHDHSWRWVARCFAACIYLRRGDHTLSQHSLADADAEFERMLAPRQDPKVLLALNQTVQILQMHDQGDLTKTIMTSAYYVARRTLGPDDPVTTMARWMVYVADGQMRDRDITSATLRALHDTFVRRHGADDPRAIASLYCYGFMLNVEAQPQRAEHVLREVYDVSTRVLGPRHLQSISALTNLHRALHRQDRLDEAVAVLARAIRDSKDTLGANHPRRLESIRLLALLYRQQGRSEWTEQLYWQVLEGRVKMLGKNHAYTQGMKVDLEALLKQTGKWTVRKRVHRQTRRRSSSSSRDRGRDRGRGRGRSRTPPQAAGFRGERDSELVQEEEFEVEVESEAQLRIQDMFEWDPHEQWDETRSDGGDSDGTGSQHEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSY0</accession>
    <name>A0A1C1CSY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Riboflavin transporter MCH5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MCH5</name>
        <name evidence="5" type="ORF">CLCR_08530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08530"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06512"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF230">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="81"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="475" mass="51967" checksum="497A7F302B78554C" modified="2016-11-02" version="1">MDTASLPAVQEVRSNDLGRHELAYFTETGKEESGSTVPAFSNPLPNANDSDKHIDTINIEDPETNRVPNDEFPEGGLQAWLVLTGACLALFASFGFMVSIGTVQEYLQNHQLSAYTSRDIGWIPSVFVYLALGLGIWVGPLFDRYGPRWIALLGSISYIVMVFLLAECKKYWHFLLCLGFLGGVGGATLTTTSLAVVSHWFKRRRGLAHGIAMVGSSFGGVTIPLILRDTLPKYGFAWSMRILGFLFFGCLAIANVLMKPRLPPSPEARKQAIISLGLFGDLKFTFLTISVFAFEIVLFGALGILPTYANHGTGFPPDTGFYIISVLNASSCFGRIIPGYISDTIGRFNTLLAMILFTLLLMLVIWLPFGHSSLAALYIFCTLFGFGTGSWMALTPACIGQLCEAEQFGRFYGTCYFIGSLAALVCIPISGQLVEAAGARVMVGFMCAVTALGMGTFVLSRWACLAWRWRWRVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSZ7</accession>
    <name>A0A1C1CSZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphopantothenoylcysteine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HAL3A</name>
        <name evidence="4" type="ORF">CLCR_09063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSZ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CSZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09063"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06464"/>
    <dbReference type="eggNOG" id="KOG0672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="239" mass="26511" checksum="46399EEE8A310B4C" modified="2016-11-02" version="1">MTTNPTLSGERFSAAAFENDGKHHILLGASGSVATIKIPLIAQALGSWANVSIRIVLTEAAEHFLQGQSSEQPKLSSLVDLPNVDGIYHDDDEWSKPWVRGDKILHIELRRWAHVLIVAPLSANSLAKMVNGMSDGLLLNVIRAWDTTGLIDMRKKRIFVAPAMNTAMWRHPITKKQIKVLDEDWGEGEDGWVTILRPTEKELACGDTGDGAMMDWKQIVGRVDEYLKLGEQEHEVNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU57</accession>
    <name>A0A1C1CU57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative aryl-alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_08515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU57"/>
    <dbReference type="STRING" id="86049.A0A1C1CU57"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08515"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06140"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="360" mass="40318" checksum="15247A787E9172B6" modified="2016-11-02" version="1">MGDAGMPRSLAESLENTKVTYTQLGASGLRVSIPILGAMSFGHKDWQPWVIDDEAEVDKLLKGAYDRGLNTWDTANVYSNGESERMIGRVIKKHNIPRHKLVLLSKCFGTVGEEPGVVHIKYPEQIRQSKDYVNQGGLSRAAIFNAVEASLERLGTSYLDLLQIHRFDKSVPVEETMKALHDLVQSGKVRYIGASSMWAYQFAKLQQAAEAHNWTKFVSMQNHYSLCYREEEREMNPYCHETGVGLIPWAPLYRGLLARPLGSDATTREESMKGNPMFGGLDPVDREIIQRVQDLAAKKGWKMSQVALAWIIQKNTIPIVGFSNLARLEEAVAVRGKTLTAEEMKSLEEPYKPKAIVGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUB2</accession>
    <name>A0A1C1CUB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRCT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUB2"/>
    <dbReference type="STRING" id="86049.A0A1C1CUB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08219"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06069"/>
    <dbReference type="eggNOG" id="KOG2043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18436">
        <property type="entry name" value="BRCT_BRC1_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18437">
        <property type="entry name" value="BRCT_BRC1_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000048">
        <property type="entry name" value="DNA repair protein Rtt107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="11"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="137"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="343"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="629" mass="70172" checksum="5025DD02916C4932" modified="2016-11-02" version="1">MEIDEAVTEVNKPGLFVQCSFALVCTGTFSESEAAAMADVLRLHDGKALMAGYPEENLDLKEITHVVSDTYDFPDYNACSDALIPVVKPTWVQHCLAKKKLLNPRQYSPDPRYFMSDVCVCIADLPSGDADAIAGGVLAMGGLWSPKLTSQVTHIISLSMDSETAAVAEKRKLNAKVVLPHWVDDCLKLGRKIDEHPYQLPDPEILKSINKPPMGKRKTPVEGALHPDPTQSGQEPTAPRKLEKVFKMKQVMLATDLGISPYLRGILDELITTGGGKVTESVSKADMYICKYREGQDYKTASRAGKDVGNLAWLYFLIQTDQWTSPMRRMLHYPVAKDGLPGFPGLLISLSNYSGDARSYLENLITATGAKCTKTLKQDNTHLITAHDTSEKCAAAREWGVHVINHLWLEESYARWKMQSITDKRYTHFPQRTNLGDVCGHTQLDRGVLEQNFFPDEDTDMTDAPATKPMAQANQNTFQPPSARRVKSEQIPKTPRTPAASRLIAPGKENVTPSTTNSRKSKELAASRLHQAAEDIALYEKETKRKGGVIYGGRRKSDPERIELGRKRSMDDMDDAETSDDSDAKKVKRSIDPPQIRLVISKYEKWVNKPKDEDRDRASICILLLHCFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUG8</accession>
    <name>A0A1C1CUG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUG8"/>
    <dbReference type="STRING" id="86049.A0A1C1CUG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08011"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06009"/>
    <dbReference type="eggNOG" id="ENOG502SQ4R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="354"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="867" mass="97782" checksum="4371742F646159A1" modified="2016-11-02" version="1">MDHLDRPANPVKDQFKIAFVCLAPYDEGDFLTYPSRRGFDNMGVLEGDFTRKSADGRDEPVGITLVQSFLQSWLFFGLLCEVYRVVGRPFNQRDYISEDSLLVRGDGRGRGLTRRVNTSALPELLAFWIDSFKQKRATGELSFEDVQRLCMRIDTYLQPAYKMCFRLVRSHHSYVDEDLLLSLMCLGNTIDDAMVVVYDRCFYDFLPMQLRGTQITPPGWSPIKRRWDAPKTVFNGLLFSGWCPFDIGILKRDFGINEIIYASQLRRHGSLQRHMACSTAACTANNIDESTYKTRHGTLGSGCDGSNCDDVEFDYETICETIRSGLTPIIRSEINAHGEFEFSVVPYLGDGDSYVAISHVWAHGMGNTKRNTLPRCQLQSLHQRTVVLLGSFSAIDAPPVHANIRNRRLSYFWLDTICVPVQPANVDVRKMAISRMAQVYEQAHSVLVLDEGLLYTSLRTDDKTIKTVSYRGRRAPPPVRQKDLVMSVMFSDWWRRLWTLQEGVLPDYLFVAFADCSMHLSHVVPAGAEEHVMNRADLSSDRVKEGLTDLIEKSHLANERGIITVDRKVSKENMEYRRRVLRLLCNRATSRSSDEPICLATLMGLDPQILLDTAPEDRMQMLYACLGTLPAGLVFLPVPKLEAEHFRWAPRSLIGVPISLMTTQVLLSEEDSEAEVTDAGIRLHATGYPLASLDTPLNDNFYIFPGPPGHIPPEEDEDGLTNVDKVRASHEQVVAIVHYDQTVQDQFGDAATGFAVAPWSSLSEQDLIDPVVVLPHLRRIERAAQHPGILVTKARLVDGVWHARFLCNVWCHRNSMAMWGNNLASDPGTGTIKNRLRAERAAVAQGSRTGNMAWFRGSEVLRDWCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUH9</accession>
    <name>A0A1C1CUH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUH9"/>
    <dbReference type="STRING" id="86049.A0A1C1CUH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08977"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06006"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="272" mass="29723" checksum="68F3CB86811CAABB" modified="2016-11-02" version="1">MPAAKEPRSEIKVLMLHGYTQNGTLFHAKTRAMEKHLQKALPGISFSYPTGPLQLKPSDVPGFDPTSSEDPDSIEAYGWWRRSDPSDPPEYVGLDRGLETVAKVLESEGPFQGVIGFSQGAALAAMIASLLEGDSRKQAFAKARSKSALAIPYPASFERLNHPPLRFCAAYCGFRAPGPRYAGFYEEPHIQTPVCHFIGSLDSVVEESRTQALVDAAGGAENTQVVIHPGGHFVPSGKQYLDTIAVFIKQRMSSADETPEQEERVEDMDVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUI3</accession>
    <name>A0A1C1CUI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">C2H2 type zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_08126</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUI3"/>
    <dbReference type="STRING" id="86049.A0A1C1CUI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08126"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05990"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000146">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000181">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000239">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="125"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="330"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="576"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="125"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="373"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT52165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="702" mass="76282" checksum="94085C21D9820048" modified="2016-11-02" version="1">MDNTRGRSPSRGNAQHISPQPSPNHYPNTVQGVDPSIQQALTHGKFNTANVFNNPFLASQQQGGLQADPNQTTFYDNGQYHQNIYSDNQFGGQNLGQSYNGGGFIYQSDNMNNDFNQTYSMNQVFDMNPQNNVNPAELSKVSSPQDHQSPGLQPPENQTQSSQPGSPASTNGQFYTPQHSRNASLDPSSAYSGLSFTQHRRAPSEHSEVSSAQHSPYLAHAELHNTGVDLSHSPYLPAQSDSSNTFGIESFNLGDQAYRSPRLMPHLEGSQPGAGMDGSGLLSQPMGIPVPDVYSTQSPPQYHVQAPVVPSNHMRNTSVVSDIGQADQFAPPTINIEPAPVSRQQSFGPQGDTMEGALSPPSSNRGRNRSKSDVTFTRPLSRSSSPGLTATNAARNSLSVRASTPERGGSMSRESSPGPGVQSGRIDKNRRASTSSMGQNRDYILDLADPNRPNASQSGTSTRVQKHPATFQCTLCPKRFTRAYNLRSHLRTHTDERPFVCTVCGKAFARQHDRKRHEGLHSGEKKFVCKGELHSTPGQHWGCGRRFARADALGRHFRSEAGRICIKPLLEEEKAERQNRARMEQQQAQHAQYAQQGGLQPMPQPMMIGMDPSTGTGGFALPAALLQQYPALQNIDWSQISSVADDPGDLSDVGGMGRPSFDGSSGGEFYDEDISDGYVSGTGMDFANPPQVPGQQHMYMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUI7</accession>
    <name>A0A1C1CUI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09354"/>
    <dbReference type="OrthoDB" id="4981644at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="83" mass="9522" checksum="11EF4981279F4DBF" modified="2016-11-02" version="1">MDKREAENIPHTIVVHLPRFASKTDIREGSKDPSDDQFLATVHLWRLGLNYNVKRWMKPSSEMYVVKKTTNSSPRDSFSVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW27</accession>
    <name>A0A1C1CW27_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_09419</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW27"/>
    <dbReference type="STRING" id="86049.A0A1C1CW27"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09419"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06590"/>
    <dbReference type="OrthoDB" id="3182339at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF33">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF3638" evidence="7">
        <location>
            <begin position="1102"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="8">
        <location>
            <begin position="1415"/>
            <end position="1447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT52678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="2182" mass="245460" checksum="8F3156757AFF12D5" modified="2016-11-02" version="1">MSLTSFSEIATRCTNLNLKIRQAALAWIRQMSKLRTDQKNARADTGALKDLSRQILIACLLCRRTFALDKESQQSMFGSVGAVTDYIEASVHLHTHRNSVSNQTTLELEAKMLSDAYLARRVNGLIRVQLMRDDSAISVGVKRFWSTAALTGRWRFVHECDQTWIENQASSKVVHYNLVTGSLLVSGRAISQLPAHYMADPLYRSVFGDLELDVFAADVDDMEYVSKDEIHGHRIYFAMRGKALLIRSCSGGQRFEAVHRDRFLGDVPRAIVESSTPWMSLQDTTVVFRSRDRPFCPDLADWTLSPGFNSGSKSTMSTCQKKLIDVNGQFGASICNIFLPIESSDNIIITVTRESSVEVELPRYHLHFDLDCKGRLVCRELSAFVDFDQQLGTFHGLQSRLILRAKTEVAGSRMRTVLVPIGEVNITSAKPHVRVEVQLDDSDSLSLSQFRIDERLGQLVGQDLEAHLYKVYLHAITTFPELDSLTRRTGTEESLFALSDPICRTCLPLSMRAQNILGLISRLTPVRRFYPVHLKTMQTTTFLKGLSVVAQRDIFFGTANEIVTHNMKAGCLFDAQATPLHYDGQFELLQRSHHRTRKLFPSESVASAPHSVADNEYCSRDQDSNEHLHASSTMARLVGLWPSALDVTPSLKDLVLGWQKIRGFHEETNADAFTSLLVQDMEDLLPRLIALCRSLSTSRERLAFVLSLIVFGGPAGQQLLAFGGHLRAALAFAISPALRALPIPDHDDYDLSRGYSIDHREVGTLISLCEKEFVPSEATSSSEDEDGDVISAEKIQFEQELGEQRRLILKAVKSSWPGDEVNFTSVSRKLSHYNLVDLKALLDGRFAAWHKNYVFLIQLEAYDKVLVSIRSSFVGPAMVNLVQDFGSTSPQTPPGTHFSLLDRMQRTAVTTGDYNESKPTCLDQDLSQSLSGKQALHLLISNQASRSLEELENIVTNLMRDPTESVRCYGKLIGDSIKASRHRQGQELIKMKVPAETVLAAKLVESNRHIAYILSKTQDLIQPLLPSQQGLVTARLWPQVSELSLLQLLWIDHRRLVPFTWMPILVQLAKEITAAQRIERLQKFLATGDTFALNNELANPAHSAWSPESRLDWLLLECQNNMLIRPVQLRVADELLKPHNGVVLLGMGEGKTSVILPMVATALADGMNLVRVVVLKPLAQEMLRTLSLSLAGLVGRALYYLPFSRQTTLTSETPQLLKSLYDECRQMKGILLTLPEYLNSFRLVGLDKLGPGTHELARPSYELVYTNGEANLLSGAPKRWNVALDILDVVRKNANDLQRRFPTAFEVESRGQGCFPHIRVLDDSGATPLARVVTQAIVDGHIPTLSLGHCNPHVLQAISAFILDIDVEDSQFRLLTEHFQDAGKFDLLYVVRGLISHGILSHTLGKRWLVNYGLDRSRTLSAVPYRAKGFSSPSAEFAQPEAAILLTALSFYYTGLLRTDLRRCLLILMRLPDPADAYAKWVRQSTLPKKYQRAASINLDDASCVDELYTHLKYNSELIHFFLRHVVYPSEAKEFRYKLSTSAWDLCRSGKVVTGGFSGTCDSRIPIIQKDLPDLRHIPATTLTTLLRWENRQYFSAASQSGGRLTTKDLLQRIIAEGPVDVCIDVGAQMLEGNLEIAHLWLHLSPKEKLAAIYFSESDQKMVLNRDGSTEPLVSSIFKDELGSCLIFLDEFHTRGTDFQLPDNFTAAVLLGPDILKDSLAQACMRMRKLAVSQSVRFYAPPEVDQAIRSVMKDPSEEVTSLHVVLWAIKQSCLTLKKQGPLYATRGLLHSRRRLAAERHVSPEGDIVNPESYLDTVRERECRPVSELYRVDRRSRAAMPFEPTVEEVQDAVMKELVLEFHVTSDSDCQDNGITQEQEREILHEVEEERELQRPREVEPATPHHCRSLLDHVRDGTPFPGTSELRPCFDVLKQTRLDYFYKPKEFPMHVLVTPDFLQTIIPVGNSPQDDFLRPVQWVLKTWGLAQPVIISSHEAQLFLPAIRASKRTTLYMYQARTSRDMVPFDGLDICKIPDNNRSGEIKPLAIALLNLFAGQLYFSSFNHYKTMCTVIGLFDGERPLPHKRNVADDNFVSPTCRLANDWTECTFKTSPVGWIKSFITMRRLGIEWSHTHMGRVLNGKILRREDFDEGDDVEHGKDLVEKMAGLTLDEKDGMDDSESLNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW80</accession>
    <name>A0A1C1CW80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 30 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_10078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW80"/>
    <dbReference type="STRING" id="86049.A0A1C1CW80"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10078"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04148"/>
    <dbReference type="eggNOG" id="KOG2566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012317190" evidence="5">
        <location>
            <begin position="16"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="6">
        <location>
            <begin position="124"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="7">
        <location>
            <begin position="360"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="449" mass="48967" checksum="6297397EC0CA24B9" modified="2016-11-02" version="1">MEALLVVALATGASAWSYATNMTYSATITVDAAQKYQTMIGGGCSGAFGIACQHFGSVGLSPANQELVTQILFDENIGGLSIVRNDIGSTPGVVRGDVASILRDCPPTPAGPFNYVWDGNDTCQLQLTKTALKYNPNAYVYADAWSAPGCMKTVGTEDNGGFICGVRGSSNCSGDWRQAYADYLVQYVKFYEQEGIEVQLLGAYNEPDFNPVKYASMESDGYQAKDFLEVLYPTAKAAFPNISIACCDATGARQQRNILYELEQAGGADLFDVATWHNYQSNPERPFNSNGKPNMMTEWADWALYMHNAFVNSDTSGYTHWYCAQNSTGDNALIRLNHDDYFVSARLWAFASYFRFARPGSVRIEASSNAEHVYVSAYVNTNGTVAIPVINAAHFPYQVTINLNGISATTATAYLTDNEHNVTMAGQTQIGGSFQVTVEPRAMKTYFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWH2</accession>
    <name>A0A1C1CWH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWH2"/>
    <dbReference type="STRING" id="86049.A0A1C1CWH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10189"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04155"/>
    <dbReference type="eggNOG" id="ENOG502QRGR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031563">
        <property type="entry name" value="MOT1/MOT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970:SF9">
        <property type="entry name" value="MOLYBDATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16983">
        <property type="entry name" value="MFS_MOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="464" mass="49545" checksum="CE9F2C3618CC37CB" modified="2016-11-02" version="1">MMQSRLGHLAAHNLSTFRRQPWNEISGSLGDLGTFLPIVIALAEGHQISLTTTLIFTGVYNILTGAFFGIPLPVQPMKAIAAVAILKSLTAGQTAAAGLFVSTCILLFSITGLLTWFTRVIPIPVVKGIQVGAGLSLILAAGGKALASLSWTAPSWLDNYLWMILAFLALFATSLRPRTPYALLVFLVGIAFAIVQVVVAGRDDDKHDGQLPGFRLWRPYVQAPTGDEWRTGILDAGVGQLPLTTLNSIIAVTHLAADLLPEIETPSVTAIGTSVAAMNLVGCWFGAMPVCHGSGGLAAQYRFGARSGASVIFLGLLKLVVGVLFGESLADLLGRFPLALLSVMIIAAGLELASVGESLNTPRARDLGKVEGGEEEEAEEEEEEEEGGRRRGEMTDDERKRRWSVMLVTAGLLIAFKNDAVGFVAGMCCHWSFQLSSYMTMRTRTSSTRAVTLEDAEEGEALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWI2</accession>
    <name>A0A1C1CWI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_10641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWI2"/>
    <dbReference type="STRING" id="86049.A0A1C1CWI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10641"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04164"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4147963at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF306">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="30"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT52820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="251" mass="27439" checksum="7256C459F48CDD96" modified="2016-11-02" version="1">MNTKYPTGSFLYLNRENDDSTGPSSSSVKLQIAIVGAGVGGLSAAIALRREGHDVTVFESTPVLSEIGAGIHVPPNSTRILHSWGLEAALRKISMMPRSLLWRRWENGKVIGNSRLNPECQDWFGSPYYVTHRAHLHEILHRKAVELGVIVRLASRVEQYNPDEPSFVLEGGETVRADLVVAADGIKSLARKTLLGMADSGLRDHGLAVYRATVSVEEMLKNEKTAPLVQSPNLHLWCVEGGSTVGLETDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXA5</accession>
    <name>A0A1C1CXA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10973"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04360"/>
    <dbReference type="OrthoDB" id="4141343at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651128" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="14980" checksum="B9C1DDAD59F964B2" modified="2016-11-02" version="1">MPAFKKLLPVLFLVPTLVFGYPPSAPASSDDTDKITCFEQGSGFVTTAQANDLVNEFNRLICQSNPSAGISLNGLEGVSVNDPSGTIIFQNTLTQVATPPNCGEVVEDFQKLLDACFTNQGSYGGVLIETAGGGATSYIIKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYK1</accession>
    <name>A0A1C1CYK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative proteasome subunit alpha type-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYK1"/>
    <dbReference type="STRING" id="86049.A0A1C1CYK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10868"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00519"/>
    <dbReference type="eggNOG" id="KOG0178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="173" mass="19419" checksum="32EDD403F88C36CD" modified="2016-11-02" version="1">MTADANILINFARQAAQRYLLTYNEDIPCEQLVRRLCDLKQGYTQHGGLRPFGVSFIYAGWDPQRQFQLYQSNPSGNYGGWKATSVGANNASAQSLLKQDYKEDCDLKEACGMAVKVLSKTMDSTRLSSEKIEFATVGKTKDGKIYHHLWSGDEIMTLLKEHGLAKEEEQETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYK4</accession>
    <name>A0A1C1CYK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Decarboxylase NovR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">novR</name>
        <name evidence="2" type="ORF">CLCR_10443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYK4"/>
    <dbReference type="STRING" id="86049.A0A1C1CYK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10443"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00446"/>
    <dbReference type="eggNOG" id="KOG3699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF39">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="50"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="285" mass="31314" checksum="45A817EA2652DE3A" modified="2016-11-02" version="1">MAPALDVYDSSTPSNVAVGALGTTTSGKKLRIRAYPKFQSLEEERLYRKQHLAAAFRVFAERGFDEGVAGHISVRDPILTDHFWLNPLSQHFSQISVSDLILVNEDGQVVEGDEPINAAAFAIHSEIHKARPDVDAACHAHSVYGKAFSAFGRELDMMTQDSLRFWKSHAVYDNFGGVVLDREEGKRIAKALGNGKAVILQNHGLLTVGKTVDSAAFWFISLDKTCHAQLLADAASAGSGHKIKLISDEEAQFSYSQVGTDEKGWLAFQPYYDEQLAKTNGNFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYT8</accession>
    <name>A0A1C1CYT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_09531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYT8"/>
    <dbReference type="STRING" id="86049.A0A1C1CYT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09531"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00608"/>
    <dbReference type="eggNOG" id="ENOG502RM76">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="41200at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF47">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 122 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="153"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="504"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="681"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="988" mass="107893" checksum="ACFCE126C45FA384" modified="2016-11-02" version="1">MEERPDSVEATEGDDDRSESSPVVPKHSAPPPTQPAQPLTTSAVVDATLKFLANASNETLGACAVGLCASTYLVLGRVGLVLIGAVGGVVLHATWESHYGGRSEEEKAELDRRRKELGVEVARRVLDWRERRAPGDDESDSNESKVLDYSDFEPETRASLTNFTDAVMRDYVRWWYSPLLPKDQSFPAAARNTFTSFVLSVSNHLSRKRAADPVLDFFANSTSIIIVFLNELSTAIKASAYQDAETAIKTYLQLQPESSLANVLSRDQQDRKFTLVADDILQNFLDPKAYNCPPVKAFLREVLAGLVLETTVDMCSKPEWINGWIVFLLEQGEPEIMNAIDAGVEDMSEAMSHAKENLDPGKSHNRRVSRAEEAMQEAMREAQRLNEMIAEDEARRKRGVPASEPEETSSVATNDVGLATPTSSDSDRNRQAESSLDTSLVFDNDGNAYSSTTSSPSKEQAPFTNFDQLTETAPNVVPPSPVSTAPAPVEVMMAVPLTLHNASITILDLGDLNEKSTFRQRPNNEYLLQIEPASQRYPGWMVSRRYPDFEPLHQTLTTIARISGVPEFGQKYPNLPSWRGQTGSTLTQSLEAYLKFIVRYEPLAETEAMKKFLDKETGLQKAPAQSKNVLVQGGAALENVGKNFINVLGQGGKNIAGGGKAVLGGVQGVFGAVATGVQGAPKRLISTRPSPSRTPSGQPSISASRFSQELPRQSSDSIESRLPPLPARPTVGTPNQEYAQSPISQHDSARQSEESISMPPLPSMIPDDYQPLSISKPATPPRPRQDTITPTTPAPSMKPEELVSALATDTPAKKAPSRKAKKDIPISEEETRILVELIFAILTELYSMGGAWSIRLSLLGAAKTFLLRPNNPQLESIRTLIQESVVDANFSDKGLATHINTLRYNTLPTAEEKATWPKELTSEEKEALRIKARRLLVERGMPQALTSVMGAAASGEALGKVFDCLQVESVARGLIFALMLQAIRATTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ21</accession>
    <name>A0A1C1CZ21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ser/Thr protein phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_09650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ21"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ21"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09650"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00705"/>
    <dbReference type="eggNOG" id="KOG3770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF27">
        <property type="entry name" value="ACL091CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651207" evidence="3">
        <location>
            <begin position="23"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="232"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="691" mass="75929" checksum="0F75EFE5D9C0E905" modified="2016-11-02" version="1">MYCSSCSLLPALALLSCQYAHAQPSSSQLLAYTVPAGFPTSLFPAYYIPPSPTQEPQPIVFDPALNYTFPLELTNQTNIPEESEDPIFFPTPLFTVTNGSAIVADAISQFNAILATDATNCTKCISALEVGQYVAQRVPTLVPDLLFQLCVSTGFGSNTSCHESYDAENFGAIYTQVLVLANVSGSDGQYLCNFVSGNFCPRPFTLPSNTTAYFGPKPSNVTVPKPSGQRVKVVHLSDFHIDPRYDVGSEANCTSGLCCRSNNPKSASGELEIASPLYGAFKCDSPYFLLTSALQSIGPLTGTTSNNMSDSDQFAWGIYTGDLVSHESQNELSNNYTEYAEVSIYHMIKSFIPSGPIFPVLGNHDTNPDGINSPHSLPGPLGQQQSWNWNHVASLWQQNNWITPEAAQEARTHYGGYSINHPKYPKLRIITFNTDFWYRSNILNYINTTNPDNSGAFHFVAQELLDAESKGERVWLIGHVLSGWDGSNPLPNPTDLFYQIVDRFSPHVIAGVFFGHTHEDQFFIYYSNNGTTQDAAHAVNVGWMGPSVTPLTNLNSGYRMYEVDTGDFSVYNAYTYYTNVSAFQTIDAAETGPVWKFEYSTRDTYQIGWPADAPLNATYWQKVTEAMAANHTLVSIHNTYQGKMSVKTPNCTSNACAEARVCYMRSGSVALGRQCPQGFGSVQSPFTGKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZI8</accession>
    <name>A0A1C1CZI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bacilysin biosynthesis oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_10323</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZI8"/>
    <dbReference type="STRING" id="86049.A0A1C1CZI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10323"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00865"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF28">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT53957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="326" mass="34212" checksum="C598CB6815B784B4" modified="2016-11-02" version="1">MAQNGSQGAPHAPSFAYPTADSPVGNIASLQDKVALITGASSGLGRAIAQAYAAAGAYVVSADLTPNPPPAPTIASIHKGVDLVTSTVELINSKWPAHGRERASFIKCDVTDEASVKAAVEFAVKTYGRLDIMVNNAGIAAETKSPTYNGVFQRIHETPLSVLDLTYQINIKGVWLGTKHACAQFLAQEPHPLHGRTATGATQDVHRGWIINLASILGSVGLAGASSYALSKGAVMNLTRATALEYAKDGIHVNCIQPGFTDTNMLENMYSRMGPDAMAQYMASVHPWGRTGRVEDIARVAVFLAGEGSSWVTGHGLAVDGGYLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZN2</accession>
    <name>A0A1C1CZN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10611"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00890"/>
    <dbReference type="OrthoDB" id="4154789at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="301" mass="33902" checksum="27B26D57B0821E95" modified="2016-11-02" version="1">MPKNRKPTVYLFVNKDSASLSLSRSHGKDASAILSHVQSCRNQKNKRLHMFRVDDGVPEPPAKRPSSRPPRLSPQSLASSRQSSPRPPPSPWTETSSSSSPSVSPSPLSSSIDSASPRPHRTETPDVDELVDYFHSVRLTSDHQSGIPLHRHDLYQQIVSSDDFQNFSRRIAGGINGYAMLACTAARMAIDTPSRREEFEIKATRYMQPSLQWLREQLADPQARIFSDRQILQEMLLHCVTNWYLGEFAAAQTHLKAMSCFTASLDLSKSSDRNLMDIINRCGLYITNQRRAEHLPHRGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZP3</accession>
    <name>A0A1C1CZP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11089"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="86" mass="8953" checksum="F1B1B82918076BFA" modified="2016-11-02" version="1">MTVFTRSVTVTEGHNGVAWGRKEMGQKKKAGGKQLTGLMGDGGGGGRLNPPSAVDILSSCVGELRPSLQDTGSPSGNGPRLFRIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D193</accession>
    <name>A0A1C1D193_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D193"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03112"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04738"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF24">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="25989" checksum="338BFE35DEAC8DF8" modified="2016-11-02" version="1">MAPTLVLVRHAEALHNQTNDPSIPDPELSSLGIEQCAALRDSLKERFPKTADVELIVVSPMRRTLQTASIALDWLISEGVKVEVDADWQEIYDKPCDTGSPLSDLEAEFPAFDFSVVDPVYPNKSSPEGKRYAHNRSAVLARAQAALGKLYGRPEKLIIVVSHSSFMRLAVSGTYYTNADYRIFDFSERKSNDEPYSLTEWESTRSNGGGMGLSPKGQVELGSGNLPPDAGSARLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1R4</accession>
    <name>A0A1C1D1R4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_02873</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1R4"/>
    <dbReference type="STRING" id="86049.A0A1C1D1R4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02873"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04826"/>
    <dbReference type="eggNOG" id="ENOG502S30T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5377273at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="8">
        <location>
            <begin position="403"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="296"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="554" mass="60902" checksum="79F3D2937973B364" modified="2016-11-02" version="1">MRQQHEQKPDPESTGTNLNLPFPPIHVHVLVHVHGFVYVHTDDAASAITAATIALACTIATTDPSDLNGGHLSPRALEKQPVRDARELTPDTHLYISKPLPPPPTAARAPAPAPAESRNSYRRSFLEALLPRQYQKKALPPDTRSATSRVLNPINYVPRPTPVRVQPERPKHIPQLDTDVRGVGEVNTLLTLPEQRRSRQHSPTDPIVEHSPHLTPTGDRTSIALPSNLEQRGTAHPPESSAWGGTAGLMVDLEKQDSSTNGIRQPEKAQTIPTSKYNAEGIATQQGSSVLAQSYGVNPLDQPLQPPRRITSHKSLKRAQSAASIHSAGFPGGRTYTDPTHPPTTGASQSDAERGLSRHDGTEDGEDDGGVAEELAWGPSHPCFPHVNPHVPLSSREYTATRIIRVRRDWMVAGDLAPTFSNIYPEILDPLMQEAEFRYVIEHINQTLCQAYDPFSAWNWFDGILGVLTGWFWEDFRPWGIKGALTGLEEWLEDWNHTVGARDGVKIIPLRRTGYLCLDVQIPDPQVRVVGEDESQARPNTDGEGTAPPTGKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2H3</accession>
    <name>A0A1C1D2H3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2H3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03188"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04971"/>
    <dbReference type="eggNOG" id="ENOG502SXRJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5394455at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="108" mass="11725" checksum="E7CF95012A9244C7" modified="2016-11-02" version="1">MQIAAFLSDLKSLTICSHEAAIALVKPPAPAGAEATDTTAPNESEDVAAHSSGRDTRRDDQDLRRANELISLHYDVKLKYLETGPDPELEQAGRDVDEVLAALSRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2K1</accession>
    <name>A0A1C1D2K1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">monoamine oxidase</fullName>
            <ecNumber evidence="2">1.4.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_03117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.4" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2K1"/>
    <dbReference type="STRING" id="86049.A0A1C1D2K1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03117"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05099"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="4">
        <location>
            <begin position="15"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT55007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="208" mass="22618" checksum="1DBBBD0CB1425B74" modified="2016-11-02" version="1">MTQPIYDVAIVGAGLSGLQAAYTVHQEGLSYVVLEARDRVGGRTLTARSSAKGSAKAELGAAWINDTNQSRMWALAEELGLHTLVQNTKGHVVVQDFDGSLVKFPYGDAPKYRSDQDTESCISIRDLVENLSTTQSPSIFSAGPHRDRLDSISFETFLHRSRRTDKALATAQVWTHAMLGVDPSEVSALYFIECKSLPPPPPPPPPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6F7</accession>
    <name>A0A1C1C6F7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar basic amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_00090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6F7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00090"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05494"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF78">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="29"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="585" mass="61808" checksum="6E7F6F53625E9FCE" modified="2016-11-02" version="1">MAAPTTSSVELVDTQDQSHQFKFARLLVILSALAFTLFVSFVDQTSVSTALPEIAESLNAFESISWAGTSFLVANTAFQLINGRMSDIFGRRNCLIVCMGLLALGDLLCGFAKSAPQLYVFRGIAGVGAGGINRSVCPEPRKDPFPPTLEGECVTDLRANPSLVMIIFTDMTTLQQRGKYQGLLETNIALGNGVGPLIGGALSQSSATWRWTFWFIPPVTVAAGISVLLALPQQKISGSIKTKLKTIDYGGMFLSLAGVIFLLVPISSGGSSWPWASPLIISFLVIGSILTVAFVEVEWKVARLPLVPMRLFEKTTARILFVHNFITGIVYYSSLYYLPLSFQVVLGQTPLMSGVLILPLIMGFSAASTGAGFCLSYLGRYNPIIRAGYILWTTGAGARMAFGENTSLGVAVGCLLVEGFGMGFSFQPVMIALLANTRKPDRAVVTGLRNFLRTVGGAVGLAISAAITNNVLQANLDSDGELGSSSAVQLIGALDTLPKGDQEAIQAAYMKGLKIVFYLGCPLIGACLLSSLALVDVPLATAHSNEGSGPPREQAVVSDDGSQCQGAGPGVDIPMVVPIATKTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6G4</accession>
    <name>A0A1C1C6G4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6G4"/>
    <dbReference type="STRING" id="86049.A0A1C1C6G4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00692"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01061"/>
    <dbReference type="eggNOG" id="ENOG502S70K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2399148at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="249" mass="27138" checksum="377AF12E40EB2E3C" modified="2016-11-02" version="1">MARIRMLRASRQAAVFALGAAAGTQVSAIPSPFRTAYAEAPSKDELPDKKPIYSAYPVAPTTPQPSSTSPVSQPHPTSPTPTDRLAEQVKNARVFLYHHSLSAETSFNNFLSWAFRKETDFSNTIASLAPKPETGEQLLPGAIYVLVATLTGSIISRNRGIFLRTTFPLAVGVAAGWYLIPVTMRNTSDLIWEVEKRVPVVADTHSQISAFVQEAWKQTRGITQGAAEWADEKAIEARKSVEDLVSKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7C9</accession>
    <name>A0A1C1C7C9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7C9"/>
    <dbReference type="STRING" id="86049.A0A1C1C7C9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06230"/>
    <dbReference type="OrthoDB" id="4161830at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="263" mass="27604" checksum="71736A06DECB5970" modified="2016-11-02" version="1">MPPTTTTEESSWLDWTSSETPAPATSSWVDWTSSEAPAPETSSWADWTSSEAPAPETSSWADWTSSEAPAPATSSWVDWTPSPTPVAPTTTTAESSWLDWTSSETPAPETSSWVDWTSSATPTPEETSWLDWTSSTTPTPEETSWLDWTSSATPTPESSWLDWTPSSISPSPTSSSGWADWTSTMTTSPSTPVAPSSHSKTLHYSTATSRTWQVVGPSSSAHPSATMSTPAAPIASGFTGAASKLGSSAGVILAAACAGLVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7K2</accession>
    <name>A0A1C1C7K2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative agmatinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_05671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7K2"/>
    <dbReference type="STRING" id="86049.A0A1C1C7K2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05671"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07172"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF30">
        <property type="entry name" value="AGMATINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650614" evidence="6">
        <location>
            <begin position="18"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="474" mass="51154" checksum="448AAD0A4CE348F0" modified="2016-11-02" version="1">MLLTVALAAACASCALAHGSHDQTPVSGPHRSLWYNTLPGDGGTQADSVFSGISTFGRLPYFPCLSSDDEKYDIAFIGAFLSSYCSRCPVSRTQELTRATTHTQARRLTPAHPTDQVLGSDPAGSDKVLDASISSTSPAHTLTWGSFRGNPGSRKLGFSGGYNVPMKSNPFNFWGKVIDCGDIPVTSYDNHYALQQIEDGHNALLTRQPYTSASEPGISKSGKTLPRIITRGLTGGGWRRRYQLGGDHTITLPLLRSINKAYGPISVIHFDSHLDTWKPKVFGGAPSKQAAINHGTYFYWASEEGLLANDSSIHAGIRTTLSGPSDYDNDGYCGFTRVEAREIDTIGIPGIIKRIRDRVGTTNPVYLSIDIDTLDPAFAPATGTPETGGWSTRELRTIIRGLEGINFVAADLVEVAPAYDTNAELTTMAAADVLYEVMTIMVKKGPLTKEVSHGEYVVGEDVARMLAEAEKMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7T1</accession>
    <name>A0A1C1C7T1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_11201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7T1"/>
    <dbReference type="STRING" id="86049.A0A1C1C7T1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11201"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07270"/>
    <dbReference type="eggNOG" id="ENOG502QUVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052515">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013944">
        <property type="entry name" value="OxRdtase_put_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249:SF1">
        <property type="entry name" value="D-GLUCOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249">
        <property type="entry name" value="UDP-N-ACETYL-2-AMINO-2-DEOXY-D-GLUCURONATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08635">
        <property type="entry name" value="ox_reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase putative C-terminal" evidence="3">
        <location>
            <begin position="153"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="396" mass="44337" checksum="7ED13A11B0F06679" modified="2016-11-02" version="1">MRRPGNISFGNDNVLWTHSLRIEKLLRTRLEVIAIIDPSVERVSQVLLQKRAVAAAPCYATTKHFLTVQEAKEHLTDGMLAHPDLIVLATPPHYRGTRHLGRDLEAQIIETFGSAPRLFCEKPLSTARPAEVWPVATFLRDAGNIVSVGYMLRYLKVVQHAMAVLRENNVAVMAVTARYTMAYSKVRKLDWWNKAKQCGPIVEQATHFCDLCRYLGGEVDLDSVRACALEHDEPVGTLSSMAVDDSQIPRDDRIPRATAAFWKYRTGAVGSLVHTVTLHGIKYSNEIVVGGDGFQLRLVDLYGSSPTLYVRTPASEHEDSFSYANDDPFYTEFAALLEPHGVSLSQRNASNPEGRHDRESLSSCPPAKILSSYEDACKTYEFTWRIRDESEKSSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C817</accession>
    <name>A0A1C1C817_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial GTPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mtg1</name>
        <name evidence="6" type="ORF">CLCR_06047</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Mitochondrial GTPase involved in assembly of the large ribosomal subunit. Plays a role in expression of the mitochondrial translational machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C817"/>
    <dbReference type="STRING" id="86049.A0A1C1C817"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06047"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07318"/>
    <dbReference type="eggNOG" id="KOG2485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="5">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="141"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT44646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="338" mass="37646" checksum="829BA191BF9953DA" modified="2016-11-02" version="1">MAAFVPRQVYPHLGSIPRSYYLGHHAAGLSKMKSMVSQIDLVIECRDYRTPIVSRNPMFEANLGERPRLIVYTKQDLGSNLTNEDKQRERIIQKWDAPSISFFTDIKARATINKVLDFARAHANASTSLFGTRLMVVGMPNVGKSSLLNALRNVSLGKKKAARTGDQPGVTRKIGSDVKIIEAEEGREAVYVLDTPGVFVPYVPDAESMLKLALCGSVKDTIIPPTTIADYLLYHLNLRNPKLYNTFSEPSNDIFAVLEGLARKQGRLKKGGLPDFESSALQFVQRWRSGQMGRFILDDVTEDALAERTQRLELLGGSMNQARKAAKQLRKEAYMAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C937</accession>
    <name>A0A1C1C937_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C937"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06451"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="78" mass="8928" checksum="47DAFB14D83B7BF8" modified="2016-11-02" version="1">MPHEAHTPIRHHGPIDSDDNGAHADTAQNQFDQLLIRSQARSRHCLGHGWKLFNGFLDLAGHEATRDPDLEHEHEHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C952</accession>
    <name>A0A1C1C952_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hcs1</name>
        <name evidence="8" type="ORF">CLCR_05782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C952"/>
    <dbReference type="STRING" id="86049.A0A1C1C952"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05782"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07673"/>
    <dbReference type="eggNOG" id="KOG1393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="178"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="467" mass="51672" checksum="EEC70FB9B6603AAC" modified="2016-11-02" version="1">MASRPQNIGIKAIEIYFPNQCVDQAELEKFDGVAAGKYTIGLGQTRMSFCDDREDIYSIALTTLTSLIKKYNIDLNNVGRLEVGTETMLDKSKSVKSVLMQLFQESGNFNVEGVDSYNACYGGTNAVFNSLNWIESSAWDGRDAIVLAGDIALYKKGNARPTGGAGCVALLIGPDAPIAFEAGLRGSYITHAYDFYKPDLTSEYPYVDGQFSLKCYTEAVDACYKAYNARERALQSQTNGVNGHHVNGNGAHKEEADKAPVDRFDYMAFHAPTCKLVSKSYARLLYNDFLEDPGHPQFSEVPPELRDLDYQASLSDKTVEKTFMGLTKKRFAERVQPAIQVATMCGNMYCGSVYGGLVGLISNIAPKTLQGKRVGVFSYGSGLASSMFSLKVVGDTTEMAEKLNLQERLDARRVVAPEVYDDMCLLREKAHLKKDFKPAGEVEHLVPGTYYLTEVDEMFRRKYDVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9F6</accession>
    <name>A0A1C1C9F6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_06251</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9F6"/>
    <dbReference type="STRING" id="86049.A0A1C1C9F6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06251"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07820"/>
    <dbReference type="eggNOG" id="KOG3389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT45160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="228" mass="25805" checksum="20B7F8276816C13A" modified="2016-11-02" version="1">MSLLRTQSSLRLSRTCTQIPRSTRHVSQTPYRRIGDPDPRAIPDVEAMKMTEDQASMVAVDHKPGPAVQKYHPDHQPDYTATVDHGTSAYSPVPRRVMDGSEPGHFTPAAVVSGAPVDLQARTVRIYKPVRPATQSGTWGSHAWRMDWDVLGKGHRWENPLMGWQSSADFMQGTKIQFKSKEDAIAFAEKQGYEWYVQEPQERRVVPKAYANNFLHESGTRLKHIKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9Q2</accession>
    <name>A0A1C1C9Q2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative translation initiation factor eIF4E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_05929</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9Q2"/>
    <dbReference type="STRING" id="86049.A0A1C1C9Q2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05929"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07855"/>
    <dbReference type="OrthoDB" id="17977at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF66">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT45198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="395" mass="43712" checksum="95D99F68143A0454" modified="2016-11-02" version="1">MSSTIARTTTTSTTTLPTARDTRIHSTNAITTSSSSASAEPSASLSLSISTAATATATQFRRTGNSNNNNNSNNNNNSNNNNNNNPPPPPSEPSSRRPSLPRRSSSLHKLLITKLRPLPFQYLWWVWHSKSAGPVASTTQQPQPQPQPQPPRRPVLDAYQLNLLVENVADIGAFYRIFNNLPWTSIRWGDSIHIFRAAVRPLWEDEENRRGGRWLIRVRPEMGAPADREADAHAHSNVHADARVRSEHSKGQDGRRKDVRTWEEICLLCLGGELQSVIAQERDHILGLSFSPRANFTHISIWTKQGDNPRSILLLERAIFSGLSPDLRPKSSTDFNYRRHAEKIGAGSALGMQMMQSRQQSQVQVPMMGSFQSTLPPTSSAAMGRPGPIRALTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAN4</accession>
    <name>A0A1C1CAN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cas1p 10 TM acyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_01478</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. CASD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01478"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03486"/>
    <dbReference type="eggNOG" id="KOG1699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012419">
        <property type="entry name" value="Cas1_AcylTrans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07779">
        <property type="entry name" value="Cas1_AcylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Cas1p 10 TM acyl transferase" evidence="9">
        <location>
            <begin position="128"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT45575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="635" mass="71200" checksum="8442AB27037EB0BE" modified="2016-11-02" version="1">MSIYGDVDAQQVFLTIAASLDQNHLTNSSLQLRAGFENATILQSELAQIAYQPDAAWNSTNYKGRSGLYAILNITSSEREYPLRNDSAMFMGGSFTFTEDDPRSPSARAQIVLNYFCNGLLEAAQKQTQAYCCAGYVPPNTVQKLLLLAGLCAILLHLCLWVLHRKLFGLSGNNVQSALETRRVVAAVATTSAAVITCFVADRTALLEKASKDVDLTTFIFLTSVAFLAGIVTCRHCQSPSNASNQSKGSAQGDHFFLSRQQTEEWKGWMQIVILLYHYFGMSKILWVYQFVRLLVASYLFMTGFGHTTYFITTNDFSYRRCASVLWRTNLLNITLAFVLGTRYDLYYFPMLTSVWFLIVWITIPRTPESGVDMYYCVRRTVLSAVVVRLTLERGASIASLLNRFGAAWIGLPEIDGGEFLFRFGLDAYIVYVGMVTAILFAWSKGRKGLPHHSPSWSPRACPRLSSTVVVLAAALGVPAYAWFCHAFRDKIEYNKWHPFVSPLPVISFIILRNSTCRLSTHYSRLFAWFGRCSLETFVLQYHLWLAADARGVLHTGLFNNLLRPIHARYMLGVLDTALIFTSFVSISCSTSKALSILTKSLVDLQAKILLVIIGLWITNLAWSIPALGRHDYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAT6</accession>
    <name>A0A1C1CAT6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAT6"/>
    <dbReference type="STRING" id="86049.A0A1C1CAT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01393"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03569"/>
    <dbReference type="eggNOG" id="ENOG502QXVT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="807"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="945"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="692"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1116" mass="123181" checksum="0123DE6DA094C378" modified="2016-11-02" version="1">MALDYLAALRDSYAPHSADHGDFHPDLRHLAPLNIEHLSLGQYNVKVASHDSQPFLEEKVALGRHPSTSRGESSPFSFSWLTSSAHVDRPASTHSPAMSPKSSYPSQAGKCPLPDCGKVFKDMKAHMLTHQAERPEKCPVISCDYHQKGFARKYDMNRHTLTHFLGAMDCGFCPGSGTTSAKTFNRVDVFKRHLTSVHGVDPTPPNSRRRSLPHTSRKLSSYCRDATGICSICRIRFANPQEFYTHLDNCVLRAVQEQQSDDNGTLGVGKNAMLLAAPAWDNAVQESLSAHRVDAGALPIGSPSRAAKKGLTRFTGGVPLVGKERKRRKHYPASWGLSTEKMSMKKRVLCVYDGDRRLHKDDMSMHKDIEVRVKLFQEDGLFTELDLEILGKTEAIEIGAAEDHARWREDRPHERPSIGSPVAPETVNDSKQMCRILPSGVLDLGSGLIKDKDISRDIPAKSDMSTVGTLNTGLVTDGERKEHLRQRCLLQKHETPSAVCLPFSAKACPLNPHLASTAQDTEEVTEPQETGVALSAGNGHHGDQDISPKCSPESVEQPTARVTEDNAGEQKSITDVVVEGVQSFSSSIQPSCPEDRSPRGSDSVSTVQAGAVTPSTPDSDTSRQSGLEADEASESEGELSFMATPGPGDVQLESETPPNSQRWAIQSTVAEQLARSYTTLLLRTRGGQGHNTGSPGSSCMESSSTSGSKSSQTMPSSPISSRKRSHTNDEKDDDHNERPRKQRNPRREYVAADDGKLLACPFSKFDPARYSELNTTELQYRGCSSCYLTTIPRLKQHLYRVHSRPLHYCSCCFQSFDTAVALDQHARARSCTVSPSPFEEKMTTDQMSEIKRRTPREERTKSWFTIFRILFPWSDLPRSPFVGDYSEECIQHFLEYFEREAPRVLAATIDSELDNSVLHLGLGQRRMLDDILETSLSHVVVSMTHAARVRQSPSRDQRPHNASIARSPELLPASLSGDTTMDDDSSSADTPLQARHVTTQMTLSQSHLSRDEGSTQSWLMVNRATEQHFDVPPPNVPVSDSCMDDLIAKLPDSSALLECADSTVIDHGLAAEEWQRLLNSATPLELELWQDGAFNLEENDPAIALTGYQPTMTWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB17</accession>
    <name>A0A1C1CB17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_01444</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RBR family. RNF14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB17"/>
    <dbReference type="STRING" id="86049.A0A1C1CB17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01444"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03559"/>
    <dbReference type="eggNOG" id="KOG1814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20354">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23134">
        <property type="entry name" value="RING-HC_ITT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000416">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047548">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="14">
        <location>
            <begin position="14"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="200"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="324"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="501"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="648"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="607"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="687"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT45659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="722" mass="81133" checksum="701D08137CFD7036" modified="2016-11-02" version="1">MEDEPQAAEDERTIELSTIAAIYPEIVVDQNDPYTATLELSVTPVQPLRILFRPSIDTTPPAPPTPPTSSDHGHDGTGNKPVVQQTLQLDDHELSHLPPLSLRITLPKDYPASEPPIVSVSVSPQWLGGPVVQRLQDDCARLWEEIGKDQVLYTYIDHVQQEAEKAFGLAGETDVSMPSDLKLALLDFDLKTKRERFEKETFDCGICLEPKKGVICHKMLQCGHVFCVPCLQDYYNNCITEGDVDNVKCLDPSCGKDEAARTGPEGRPLKRRKRDRTLNPSELLQIPIEPEQVQRYVKLKRKKRLESDKNTVYCPRQWCQGAARSKKHPKPTDPMIDSADTDESESEDGQKKAPIDLETLPMAERLAICEDCDFAFCVVCKKSWHGENARCSPRRQQELNEEERATAEYFQKFSTPCPTCNAPAQKTMGCNHMTCFKCKTHFCYLCASFLMPENPYRHYNDTSSPCYMKLWVLEEGDGEGVDRGAFHNADVVAEWEAVAAAEESDDEDELPPENFAAFRGPRPFADDEDTDDEEPAPDQRRNRNVIEIVMPGQNAQRIALPERLREAPIPPPVPIPPRGGRRRRGGGQQGNRQRAMANEPARDNHGQGHQARARAGQPAARAPRDIRVEEGLDGLGQGHPHILFHHNDPADPPGELPPAAPGQGNQQAGPVRGMGLDQFLQLAREDREDEWDSDELDEDDFGAIEFEHRPRPVQRERVMGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB79</accession>
    <name>A0A1C1CB79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB79"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01757"/>
    <dbReference type="OrthoDB" id="4161387at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650678" evidence="1">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="121" mass="11827" checksum="E6A61A73AC82AB73" modified="2016-11-02" version="1">MRTSTLFTLPLIHFAAQAAALPQLAYLARGKCSAPGQFICVSPTTYALCDASLRGIIQPLAAGDSRCGGASAAGAPLAVVPPSANAGSTGSGTVIPVVPTTCSECTSSSHGSTHGGAQPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB88</accession>
    <name>A0A1C1CB88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_01657</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB88"/>
    <dbReference type="STRING" id="86049.A0A1C1CB88"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01657"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03667"/>
    <dbReference type="eggNOG" id="KOG2307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="11">
        <location>
            <begin position="60"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT45775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="313" mass="35524" checksum="A68447D954B458BE" modified="2016-11-02" version="1">MRTTLKTTAASHNEQPLLRTAPTSSRRGPGTSNDVAQFSNSDSGSDLDDNDDTSLPFPKPLDRSSFLAPDFDAGVFLASLSNRFQTLEDLQTELRDLSQTLNKELVDLVNDNYQDFLSLGSTLSGGEEKIEDIRVGLLSFQRDVQGLRDLVEQRREEVAELLKQKKAIRQETSVGRALLEVAERLDAMEEKLNIARPNVSGPVTKAQVEENGAEQQWSEEWIEETTINESDDEYDSDDTMGMTLRLKRRTEEFLILKHLMGRHSPQHPFMLSQEGRIRKIQEFLLSDLDMEIRREAEVKTKQQMLQVRAAIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBE2</accession>
    <name>A0A1C1CBE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01728"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03687"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650751" evidence="2">
        <location>
            <begin position="28"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="106" mass="10703" checksum="34ED950916C4201B" modified="2016-11-02" version="1">MAFTVKNLILVLAFAILTRVNLPVASALPSVGGLAIHITNSLAARNTSMEAACPAGQPPNQAGWRGDAAPPAPSAVSSSLTTRAAVKTRSKNSSSMTISAILFGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC28</accession>
    <name>A0A1C1CC28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RhoGAP domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC28"/>
    <dbReference type="STRING" id="86049.A0A1C1CC28"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00396"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10000"/>
    <dbReference type="eggNOG" id="KOG4269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF125">
        <property type="entry name" value="GTPASE ACTIVATOR (BEM2), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="367"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="676" mass="74293" checksum="C75577B54708E78C" modified="2016-11-02" version="1">MPKASALPQLNLAPNNNDDLNGLTPATLSPRSTGSPHTPHTPRSAPTSPFLQGPPPSFMSHQVSASQDGAQTGASSPKITAMPELPPSPVPQSPKHARDPSKGFFSNLMASKSSHKLHASETSIPEGGERPSGRSRASSKDRSLHSVKKQGSTPELPKGGSSNGTINANNPPTMSEPTLAQPPAEPVAAGKKPKPRFGGILARTKTVRMEDLPPKQKNPPPSHLQLDTTSPGIDRLDDTSPKTAPIKFDHRDRAFGTEAGATTRNRSADRQTRDDFLSARKERQAGNLPMSHSFREGSTLQILSNIGQTGKGVGDRIGKAGKGFFGKITRSGSSNERETPTVTDDNYVCTTINLPLVKQTRKTRIARRLEVSKDKTEFWMPALPWRCIDYLNMNGAEEEGLYRIPGSGRDVKHWQRRFDTEYDINLFDEPELYDINTIGSMFKSWLRELPDEILPKAVQNKVATQCAGATSAPQLLRDELSRLPPFNYYLLFAITCHLSLLNSYADKNKMDYRNLCICFQPCLKIDAFCFQFLVMDWKNCWQGCWTEKEYLEEEYRYEREGSVNESEDLGLDERALSSSGSSQQQPAQATQATQAASPEPKPPRSADAAAHRKSMAPKTKQRSLSQGGNTRDRSNSGHGPSQSVPAVPQRIVTPEPPKLSLDQKLPELTGLSPIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC47</accession>
    <name>A0A1C1CC47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_00370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC47"/>
    <dbReference type="STRING" id="86049.A0A1C1CC47"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00370"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09970"/>
    <dbReference type="eggNOG" id="KOG2468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="679"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="784"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="824"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT46046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="898" mass="98163" checksum="57F71890D210B176" modified="2016-11-02" version="1">MTFLKPTRTDSGRSSSQEIHEQPNLRLSRTPRPYHLRGDSLSTTQSWSGAGGSTSVADGFVPSPRPSRSESSDSGTEADDEKGPFLKGLPAPALRLHKGLRGSTPANLTPAASPPSTPPAFVDGEEPRFFEQPEKREKKLQASRSQVRDYQTYKDRKRREIVRRCTETSLLCGIGVIVWNDRKASTGLQDWLNEIAAFLVIPPLVYLVYPLRLTFLALASGKTLTQSLRLGFHIPSRFDPGPLLYPVLLPSMVAVSLFHHSASFLPATIVSGLSSMPRLVTTTQFPAIGEYLHWVFSVLPLHASNHQVFTTSVFKPLSLKIGPSLTREDLVLLFPLHHVLMSVLGYLTTSSLETSELQLLSSALVSLYLFAGTPQAEILKAMIWLGGLCIFITCKHVLMWEVALARVPTWRLLKIRRNRGLVSQIDQAICTFLVRGTFRHVSREDSDSDDDVQPMKSIRKLRPRLKLQLNGRALSAMGPVEEAKSALEATATNAMSLDTATIAPPLRRNTFAAFDHGNSKQDSVTMKKAKAVPSGLSAPFLAFSLEQVRVRKYAYAAAAYFLVAATILGPVRLYVATRALSNQEPIGWALGYLLGNLPAVRFWVVSNNLERWISLPARQRVPAVAFENGLVEHLRQNVLGPATTRLAICAYCLVVLGTGIAAVLRLTSVVEVDTRRKVFHGIMVAMLLPTIYMDPCFIALALSLILAIFLLLDLFRASQLPPISKPLTVFLAPYVDGRDHRGPVIVSHIFLLIGCAIPLWLSLAAAPRVGDAPWNGWDTPVRDLSMVSGVICVGMGDAAASLIGRRYGKTKWYWVGGKSLEGSLAFAIAVTCGLLTSWAWLRLGGWMSWHDGKALGSVLGKCLVAGTGASLLESTLTAANDNVVVPVGLWLLVRGLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCI3</accession>
    <name>A0A1C1CCI3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2-dehydropantoate 2-reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_01254</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCI3"/>
    <dbReference type="STRING" id="86049.A0A1C1CCI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01254"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09287"/>
    <dbReference type="eggNOG" id="ENOG502QWBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="5">
        <location>
            <begin position="204"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39212" checksum="5A3E207097F33963" modified="2016-11-02" version="1">MAQKARVLLVGAGGIGTMTALNLERGGLAVVTAVLRSNYAVVQDKGFTIDSCDHGKFEGWRPTKVVNKIPDLSGPESSEGPFDYIICTTKNIPDVPPTLVDLIKPAVTPGHSVIVLIQNGLNIEKPLLNAFPDNICLSGVSLMGADELSPGHILENDVDRLYIGPFLSDTIDKQKQIDAAEEFVRIYSASGKVQCSYQPDVLFVRWRKLMYNAVWNPICALTDLDTTRFRLASEEQDPASPLNLLVRPAMNEIRAAAKAAANVELPESLVEDMVECDPIEIFCAPSMQQDRRKKRYMEFENILGEALREGEKAGVAMPTVKCLYGLCKAIQWRTKEQNGLVDAQKMMEERKAKTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD21</accession>
    <name>A0A1C1CD21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_01030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD21"/>
    <dbReference type="STRING" id="86049.A0A1C1CD21"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01030"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09172"/>
    <dbReference type="eggNOG" id="KOG0783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="396"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="908"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1153"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1309"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1493"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1189"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1309"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1359"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1509"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1563"/>
            <end position="1574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1597" mass="174468" checksum="89240EFC291BB39C" modified="2016-11-02" version="1">MSYNLWRCLFEDDVDAFRQYLANATVSSAAPRTTSTGQAGGFGLKSGSPGNLAASPKTPLRFRKSSGHTPANATLGKAAGAVLTRADLNTKDSFGRTILHHAASSRSEDALQFVKVLLDMPFLDLSIQDLESGWTPLHRALYFGNISAAHALMARDLQDATDYTTTAQHSHAGGLVKIKDHEGNSPFEVFGLTIAPRSLQHDSSTLAPVRDDDSTNGVDDNGDQQNEERSRRHVHPSVDLLGDEVYAFGSNKNLSLGTGDGDDRHYPERLHFERPDHLLRRLLHDHLAERQKGWVHEDLTHSTGALHSHKALPAVIRYRPVTIQNVVMSKLHTAVLTNDPVSTLYICGYGPGGRLGTGDENTSFTYRCIQAGGLAKRRISAIALGQDHSIAVCSQGEVFTWGSNRYGQLGYALPEAPKDEVPTQLVPRQLFGYIKKEVILGAAASALHSAIYTSSALYTFGKNEGQLGLMDADARSLELQVLPRRVGVSVLQSPIQSVSAIDRATIVLLENHDVIVFTHYGWTKVLFPLETFSNYYMSDNLSTRYNMETNYIKQITGGGNTICTMSSFGEVYTIEVPRVSETVPSNASTTNPTKARNALPAPSRLWSLGKAHMAATDVAVGQDSSIIICTASGSAWRKEKRANIKSVRDTKKGSGRPKDYKFVRIPNLTGVVAVRSNAFGAFMAVRKDATVTREQILPDAPSLWNDLFHLLPFQGYGSSETTPPSGNDPAQIARAVISNASAESDFLAIGHRHEPLSRSQYDLWIASTVTDVRIPIHSFVLKGRSSVMRGALTEFQETYYFAIPDVLSIEYGQDGQIQVTFKGADFLTLATFVFYLYTDNLIDVWHYTSQALHLAPRYRSVRLELMKLASHLEMRGLERAVRVMVDPVRGLANDMELAVLDPDFFSDADVLLELADDAEMPAHSVLLCSRCPFFDGLFNGRTGGMWMASRRNEAEAESEAVRVDLKHIDEKTFVMVLRHLYADTGEELFDDIVTSTLDEFLDIVIEVMSVANELMLDRLAQICQQTLGRYVSVRNICSLVNTVAESTVQSFKKAALEYICLNLESMMELRLLDELDPDLLLELDTVVQDNQLAFLPFARSERAEADLLENHPDLISQIETARQRRVDSMRLRSRLVEDEERYAASVKVRYGSLDRHASSPHNKSALRTPADASPLTTPSHSPAILANDTADDLPFDMDADIPEPLPAPAREDLNSPSAKVASSPENTRPPPRIRQSELGLSPIGALRVGGAGLSGLESHRAADPISAVTPTSGFNSRGAPWQIPLHGSKKDGLKDIMEQASAGRVSQLTQAMRSSSTTPKTNAKVSQKERKRQQQQIKEQTVKVSETVRAGPTADAPSSPWQTIAKSPKTESSPIVDARKETGKQTQAKQPITMRQPMAEASSTGPVAKEPSGGGQSPSLSPPSSKPAAPQIQSIRHTPVRTRGPPVDARTSMAEILAQQQIEKTAVKEAVAKRSLQEIQQEQEFQEWWDNESKRVQEEEAQATAAAGRRGKGGRGRGGQRRGGGRGKATLAVEANGHQRKSWSTEGPLIAQGFASGGETEPGLAGMSRGSASRGRGRGQGNTQHSHRGGQASTITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDD4</accession>
    <name>A0A1C1CDD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02170"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="109" mass="11441" checksum="D71A068C3360422D" modified="2016-11-02" version="1">MRGNCVIQFAIEDEITGSFHHALIAQEALWSVSAVTVFRPEHAVSMLHVVGHDSIAAGAAVPFVQTTTQFGNVCEAEHVLDDADEELAEEVMLPDGVVAVVEGVGVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEG3</accession>
    <name>A0A1C1CEG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEG3"/>
    <dbReference type="STRING" id="86049.A0A1C1CEG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02067"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01551"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF21">
        <property type="entry name" value="DNAJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="226" mass="25007" checksum="0B1476B6C6402EA3" modified="2016-11-02" version="1">MSDLPDYYSILEIAPNATEEEVKRAYKKAALKWHPDRVSVDSPERPKRTKRFQAINDAYYTLSDKTRRRDYDEARKFHSGSTFTFDDSADDEEVPRPPPQQAGATPSWFNMFGFGRGGDGQQSQFADQQFESAFEEMMHEDDLADDNHAPTKRFWTIVGGISGGAMGFIFGDVVGMVPGAIAGSKAGAIRDAKGKSVYKVFQSLDQGQKAKILSELAAKLFSGAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEM9</accession>
    <name>A0A1C1CEM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone transcription regulator 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hir3</name>
        <name evidence="7" type="ORF">CLCR_02214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEM9"/>
    <dbReference type="STRING" id="86049.A0A1C1CEM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02214"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02420"/>
    <dbReference type="eggNOG" id="ENOG502QQX4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1713"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1788"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1841"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1858"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1879"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1935"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1968"/>
            <end position="1983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT47000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1983" mass="222219" checksum="DAC107BD65A13A74" modified="2016-11-02" version="1">MSGFTALNVEPEDKFEEEVDDTREIQLEEAFKLYQNALKLHSQGPRYFQEAQEAYDELLRSEVFKYPEVVSEFAHDELDDEGAVAAAQTDNTALPLLPSNAAESSASSIPQLIYLAFKNRGQFILDVACHQMSDKQASRAELCRSHAESSKESLRQFAQALERDDTDLDLWKKSARVADVLSSHRIARFCLESVLAGEVEDGQQTVDISGLDEAYAAGELSQVIDLVHDDLSRLQSSNIRPKDKLLTALRESNDPYPDLPKRAQTLEYLDDRYRPLSFTVPRADLKPESTDLFALGEKIAEIVDKIHNDEGSLSCATIVKVVLPDSNLMSDPAEMKDAETEVHPNGAGQNEVLQGPLLSPTKNAMQDESSTVADIIGHESSAAPATSGQPDGDTADLAADGDTVELRSAAPPQPDSAALPSRKRSSAVAGWNEEPEGRTKSKRLRARESMADVAAQEEDTAHEQPQYFLGQLSIYEQADQAWFDVANTLLARFDMKTYPSTEQAKQSFWTGADGSEAGNHSHASEKDLRLLMDLRHALTNWTDEKGQAIVHGHGSQDFPEKATGISQFLQRSKLATPKKSQPFEEAATAAWSSLVSLINEEPTNIYDAATWWLSSLLTGCKVKGRPYASPYLLTAWSAETKYTAAHLACETEDYLWQSLQQRHERLSNLGEATRDQQSSSFQQVQSAFELVEGLFELFLDVAATVSDPNGPFDPVSRGVNIERVNRWASLASDFMQLYLSYSARGLSDPLVLRFMWTSVAHVRLDNDVEKAHLVLLLEELKAFLEKSEVSPIYLPNNTAMPEISVPAIEHQLSVLSTSDFFARVFDDDNSDPVAVIEMLEPMLDTITRSQASSTPGLSTPLARTTQAEELVKFLESNNATLTLALWRRLQNAYTSISYTPKVVSCLFRIIETIVGELHTARHLDLDATCRQVEMLKWLHDVDEVMIRLLSKIPDELAPFECIDDSHLRSSLSAITLVMRLLYGFVMYDDSVRVGQTSGPQFKGALSAKQYEKAKDRMREMLIRASNLQYLLLKEATVQDPSSYSRAADGLAEYLCTIHGCLGVRQYCKYANKALVKLVKKELSTLPTEQDYAAEVAQVFYDLYQLRFASGIGDVDHGCPPETLDRKTAWTLIPTIMKYAERFNVKDLNKSELRGTIDKMQQALGVVKSSPALQQNRLIIRDYLKGVIKAADLFDCTRGVLALPTGPVKADTEVAASTGWYFMLGHLTLSKYKSVKRVSPTSTEDLDSAMNLFRQDLNHDTEKWETWYRLAQCFEAKIEDDLIWNSAKLNDSRNDISLLERQAIHSYMMATAIAFRTEDDQPETAAKIEDMLGEFGTRLYASSRPPLDMEAFRTDKHMRHLSSTADQTMSKQPYHQPARQFALWCFAAKLLKNKLTDRPKPWMSHYTRAKCLWKIFQSPENRGRVRTEQVIEAVVAAIEALPKKEKTNEPILEPHLKLVSIVHKMLRCGKIDYQQAYQYMQATRYAHGVNLSQDEDGVDWERYMIDVLKKLSHADKANWHHRITNRAAHVLYDESPNLAGALGAKHEFTQQIFTKTMTMQVWKPEHERPGRHYVYTGRYVSFFVHVLEQLNDRGSLDALVRRIRRRAIDFLDHTKIWEEAATTYVRLLRRHGQIPEGRERALFDGMNHEEFSKKSEAMEQWSHDPDTSSVYLDVIREGVDLKRLNNSLMKGPVIDDLIGDAYACLYEEFVKQLPPDEQPKPQPAPLPQGTFINMTTDMGDGESEEAQRARLSDMLRAQGDGATDGPLSLSISAPVGLGLQNAPAPLAGVAGQPVPEVQRDRAKPGRTKTVTRREIQRKAESAIVKPPPIKTPILSKRFAVEVPSKTEVETESPVNKGVADAKDMDESRATSRRGSIQDSADGDADAEDSGSELSELEDLNEDEKQMLAEFENAQNADREGEDSDEDRENARKEGDGYGEGDDEDDDVMQDAETAIEIQDSQENAAEGQPEDKDSPDVEFHDAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CER7</accession>
    <name>A0A1C1CER7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PAT1</name>
        <name evidence="15" type="ORF">CLCR_02437</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CER7"/>
    <dbReference type="STRING" id="86049.A0A1C1CER7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02437"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02404"/>
    <dbReference type="eggNOG" id="KOG1390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="13">
        <location>
            <begin position="47"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="14">
        <location>
            <begin position="315"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="10">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT47014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="439" mass="46182" checksum="280B802C4FC1BB07" modified="2016-11-02" version="1">MPSLTTSAARTAMRASSSSARLSQMRSHLSTNATSPMARNKEVGEAYILSAARTPTAKFNGSFMSLSAPQLGAVAIKSAIEKSKVPIAKITDVYMGNVLAAGMGQAPARQASIFAGLPPSVEAVTINKVCASGLKAVAIAAQNIQLGLAEAQVAGGMESMSRVPYYLPRAAQNPAFGHMQFKDGLIEDGLWDVYNQFHMGNCAENTAKKFKISREAQDEYAIRSFERAQKAWAEGKFKDEIVPVTVKGKKGDTIISEDEGYTNLRKDKVASLKPAFVKGPDGSVTAANSSTFNDGASALVLGSKAIAQEYGQGSRVLARIISSADAATDPIDFTIAPSKAVPIALERAGLKQEDIAIWEFNEAFAAVIKANEQILGLENANVNLLGGAISLGHALGSSGSRILTTLLHQLKPGEYGCAAICNGGGAATAMIVQRIERVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF05</accession>
    <name>A0A1C1CF05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Siderophore iron transporter mirB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">mirB</name>
        <name evidence="13" type="ORF">CLCR_02321</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF05"/>
    <dbReference type="STRING" id="86049.A0A1C1CF05"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02321"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02315"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000302">
        <property type="entry name" value="MFS siderochrome iron transporter MirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF55">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="490"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="89"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT47110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="606" mass="66382" checksum="42AD166B9C70D4F6" modified="2016-11-02" version="1">MSAAGRFKLSSLGQFLRPDGNDVVEQSRGSTVLESADDKNAATHAHDPVSGSRGDDDTQPEFPAQDAQEGVKRVEAITLAWSKTSLIITYICFYLLYFVNAFQFSITANLTPYVTSGFEYHSLIPVIYIVSSVMTGAAYLPIAKMLDIWGRPEAFLFMVGLGTLGLILQAACTNIQTFCAAQVFTSIGFTGMIYSVDVMTADTSKLKNRGLAFAVTSSPYMVTAFAGPSASEGFYEDINWRWAFGTFAIVTPFVAAPLYLVMQYNLQKAKKQGLLDRPKSGRTLGQSIWYYIIEFDAFGVILLATGLVLFLLPFSLAQSTADDWESGSIIAMLVVGFVLLLAFALFERYLAPKPFIPYQLLVSRTILGALLLDAVYQIAYYCWASYFSSFLQVVNNLTIAQAGYVSSTFDIISGLWLLFVGFLMRVTGRFKWLLLCAVPLYMLGVGLMIHFRRPHTNIGYIIMCQILIAFAGSTMILCQQVAVMAAAEHGQIAAVLAMLGLFGYMGGAVGNSICGAIWTHSLPGALQRLLPDDLKPEWETIYGDLTVQLSYPMGSPGREAIMAAYGIAQRRMLIAGTSVMGLALFFVLMIRNINISTKPQVKGVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG43</accession>
    <name>A0A1C1CG43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_03656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG43"/>
    <dbReference type="STRING" id="86049.A0A1C1CG43"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03656"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01877"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057571">
        <property type="entry name" value="SDR_PhqE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23441">
        <property type="entry name" value="SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="265" mass="28151" checksum="8630774D83AFF43F" modified="2016-11-02" version="1">MTTPKYTNKLANTSVLIIGGTSGLGFGLAEALIEHCVSNLYISSSRKERVDAAISRLRSTYPDSSQTTKITGLPCNLGDEATLESNIKSLFRGIDSKLDHVVFTAGDPLAAKPLGQVDMPFMKQAGMVRFFAPFFVAKEAVGHLNAGPASSITLTTGSVSEKPIPHWAVVASYASAMHGMTRGLALDLKPVRVNLISPGGVDTELWVNSLGDREKAQAAMDGMKGKAATGDIGRVEDVVESYLYVLKDRNVTGSVVRSDGGVFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGH8</accession>
    <name>A0A1C1CGH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C3HC4 type (RING finger) zinc finger containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_03409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGH8"/>
    <dbReference type="STRING" id="86049.A0A1C1CGH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03409"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01776"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF416">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE GODZILLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="344"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT47609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="537" mass="59389" checksum="37A76D526CED0604" modified="2016-11-02" version="1">MSAQDFGVVAIVLPNPQYDPSDRAQIVNDSFGFALRASGLIRTLSPNNPHHYDAIQGLLYSPDLPPSSPCGRSTRALIPANVTTRAEIPPGDYPLIALAPWTEPECVVSYLSVMRADEVRGAIFFRPDNSSALPPPVSDQSWTLHDGGQWKSINGYPVYAIPGMLGSFLLNELAQYSGNMSEVPFGEDLITIYNPHDSVRLYARMAVHTRAGIPSLWVFLIIVLAILLAVVLMSSVIMHMIQRRQRRVLQRRVADGEVNLESLGIKRLQVPQEILDKMPQYTYTAKPEPENDNEDATKQPGGSGTSDAVGPTTQKVAESHIKDVESAIGPAATTHEVAFAQSTCPICLDDFVSGQTTVRELPCNHIFHPECIDPFLRDNSSLCPLCKKSSLPAGYCPVQVTNIMVRRERLMRRVQQRGGTIHVSTPASRLVMRGRALRAISIPTPAPRIDIHISPEQERSAGTEMDSMPSIRRMTTAEDEVPAEVRAQGVSARRAWLRDRIARRQARDYQLRADEGRVAEASRPLWRRVAGRVFPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGQ6</accession>
    <name>A0A1C1CGQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial 54S ribosomal protein YmL20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGQ6"/>
    <dbReference type="STRING" id="86049.A0A1C1CGQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03698"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04637"/>
    <dbReference type="eggNOG" id="ENOG502S0A4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6021263at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="204" mass="23951" checksum="6B0FE0A0A7056B61" modified="2016-11-02" version="1">MPTAMQSTMVTSASSRFYKLCAQILHPSFRRHQSTNTYRRTRSRLNIKPDPDFLPSKTEPHDHIIYNPPPSMPNVYHTPNLFLPKNDRRKVFPDPETRGLQLQSAQQLPAVKGQTEKRYHLTEKDLEEMRRLRMTDPTQWSVSKLSKKFDCSPVFTHLVVDGLAPQKGKEQQMVTAIIKSNWGKKRREAREDRQIRKERWLKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH81</accession>
    <name>A0A1C1CH81_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_03355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH81"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03355"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04484"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="73"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="593" mass="63427" checksum="A188176D9582FEBA" modified="2016-11-02" version="1">MSVLPPENTDRLEHERQHDAELLHDKEMTEHREHVHHDEKSQVKEELTTASPSEPSSDTPEYQTKTVWTLKTFVATVALSGLYVGSQIPLYFVGGSLTFIAADIGGSEASAWLSVSYALALSAVAPFCGYLQDLVGRRNITLGGGVALMMGCIVLATARSFGAGVVGMSFAGAGAAIGELTALAGTSELVPVNKRGIYLALVTLFVLPFAPYLLYAQLLSTYHTWRWGIWICLIWNGLWWVIIFIVYFPESQIRAKGQAAKAILKRIDYIGGALSIMGLTLILVALQAGGYSHPWSSGYVIAQLIVGVFLLAAFVVWEWKYCKDPMVPHEMFTGQRIVAMAYGIAFIAGMNFYAMLNFFPLAFSSIFDPDPVKVGLRGLAAGLSTTFGAVIANAALSWFKGHNRELLLAGCIIMTAFGGSFATVNPDREGLAIGLGTMTGFGVGAVLVPAATVAVTVTPDTSIATCVALSLTIRAVGGSIGYAIYYNVFINKLTPKLPAYIGEYAVAAGLPLSSAEQFVATYLGAPANLTAVPGVNAQIIDAAAIGSRWAYADSLKYVWLTSISFGACAIIACLFIGNISKYMTNRVAARIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHI6</accession>
    <name>A0A1C1CHI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl3</name>
        <name evidence="5" type="ORF">CLCR_04180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHI6"/>
    <dbReference type="STRING" id="86049.A0A1C1CHI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04180"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08147"/>
    <dbReference type="eggNOG" id="KOG0746">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT47980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="346" mass="39148" checksum="59F5B52AA12338CB" modified="2016-11-02" version="1">MGYKAGMTTIVRDLDRPGAKMHKKEIVEAVTVIETPPMIVVGLVGYIETPRGLRSLTTVWAEHLSDELKRRFYKNWYRSKKKAFTKYAKTHSEGKGSSVTRELERIKKYCTVVRVLAHTQIRQTPLKQKKAHLMEIQINGGSVADKVEFGHGLFEKPVEIDTIFEQDEMVDCIAVTKGHGFQGVTSRWGTKKLPRKTHKGLRKVACIGAWHPSHVQWTVARAGQMGYHHRTSVNHKVYRIGKGKDEKNAATDFDVVQKTITPMGGFVHYGEVKNDFVLLKGSVPGVKKRVVTLRKSMFPHTSRKALEKVELKWIDTSSKFGHGAYQTPQEKRQFLGTLKKDLVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHJ4</accession>
    <name>A0A1C1CHJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LSM1</name>
        <name evidence="8" type="ORF">CLCR_04340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHJ4"/>
    <dbReference type="STRING" id="86049.A0A1C1CHJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04340"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08155"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="72"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="240" mass="26947" checksum="81D561E3CEE655B9" modified="2016-11-02" version="1">MEHLSLNDPPAHPSSPRRSQGQLQQHPHQQQQQQQNAVFPGPSAPQGAPQLPPQMFTTAAQLLDLTDSTSEGDLVKSMEENKRPSPGPSNTCFFPVEKLLLVLRDGRKIFGVLRSWDQFANLVLTETRERYFVTAPPAVSTSTNPHTDSTITPSESQQHARNLYCDIPRGTFLVRGENVLLLGEVDLDKDDDPPPGYEEGDVEEVFRLQKEAEQERKRRDKARGKRTAWRDPEGSGEVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI29</accession>
    <name>A0A1C1CI29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lipid phosphate phosphatase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_04169</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI29"/>
    <dbReference type="STRING" id="86049.A0A1C1CI29"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04169"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08328"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF84">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="134"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT48179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="379" mass="41986" checksum="914AD2860D41C28B" modified="2016-11-02" version="1">MSDIQSPPIKPSRAQLSAHLYQSLSDLIPRKTTFRRLGRYSRAFFLDHWPDLLVVLLVTAVAGAVFLIPTRSPLLFPLLDPTGAVYNPSLAYPYRPAIFSSLTAGLLGSLVPLGAILISQLIIRSFADFSAATLGLFYALATGTLFQVILKKTIGGLRPHFLAVCKPRPVPLGSGVGFNGIMYRAQDVCTGSPGEIEWGVQSFPSGHSEIAFAGFGYLAIYFFTHLHRNDHGGRVGKLGFWRMLLVLMPILFATYISSTLWLSYHHHASDCLAGAAIGILTALLGFRTTYRSLADGTRNWKPRVGRRLKSALEREREEQTTAEQEQEQEQDEIELDHRHGVDGADDTGDVERAWRRSGWSPPPPSLNRRGSESTQNRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI99</accession>
    <name>A0A1C1CI99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_03828</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI99"/>
    <dbReference type="STRING" id="86049.A0A1C1CI99"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03828"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08344"/>
    <dbReference type="eggNOG" id="KOG0169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13360">
        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08558">
        <property type="entry name" value="PI-PLCc_eukaryota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037755">
        <property type="entry name" value="Plc1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="356"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="730"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="851"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="687"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT48196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1087" mass="121456" checksum="6988B37F1ADEDA0A" modified="2016-11-02" version="1">MSSNQRVNTALSQSFSAAPASANSTSSMTQSPYISSIQSSPLVPHPIYQLPQLGNPAPFDLGESLVSTHAFPSPREPSTGSKPVGIMRKLSQSAKDGVSSARQTLRRKASSSAQSRRDESTGPITRRRSDSRTAIANGHLTDALAVDVLPLELQTGLGLYGDTMSISSEPTTLADASPEGQAPCVPERLVAGCMLTKITKNKMQEKMFFMDVEGARVSWKGAVTTKTFHIDNIKSIRSGEVAASYQHELRGEAVDPGLCFTVNYATSDSSKQVKTLHLVAHDYHDLRLWVDTLESLAKHREELMTSMIGSTERESVIRAHWENEMAKRAARQDNVKPDGLDFHAIQTLCRKLHIHIPDKEIEEHFKSVDVNTSNLLDYNLFREFLRRLRERSDVKRIFDGLKGANSKGIPRSVFIDFLRRDQGFDVYGLADPLHWEEKINDLISMSFPDDPAMRALELIDANAFASFLVSKDCHVYTGAEEAVPFFDRPLSEYFISSSHNTYLTGWQVGGTASAETYITALRHGCRCVEIDCWNGQDGNPRVTHGHTRTSSVLFSDCVNAIQRCAFDVTPYPLIISLEVHCDPEQQAKMVKIMKDVFGERLLLYPLPGFDTQLPSPEDLKYKILIKVKSTELHADLAAARLPTTSYRDRSASSPNRGIVSPVNWTLLTAPQVTSSLLVTPPETIYSPTDRSVTATSASSADEESDAPAISPSTADSQRRPPKPSKVGPQLSALGVYLKGYSLRDAKDLAFQQYNHIFSLNENRAIELCRSPEDKAMFEDHNLHHLCRVYPKTLRFQSSNFDPNTFWRRGVQMVALNWQTFDAHMQMNQAMFAAGTDASGYVLKPAYLRKPRTKQGEFEHRVKLPRYRIRFSVQVISAQQLPRAANMGRDTPLNPFIEVQMFSAEDRARGIANGTGGTETYSNGYHGIGSPYRRQTQIRFGNGYNPQFGENIELSLETKYPELVFVRFIVLNSDDGRRTGKGVRQLAAFTAKLDSLQKGYRHVPLFNGHGEEFIFSTLFCKIVKEQPKLMPWSLQDVTERTSRPSVLRGILSRGLSSDRGRERLSSGEDVRAAQARLNREIEERVTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIE9</accession>
    <name>A0A1C1CIE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5'-hydroxyaverantin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adhA</name>
        <name evidence="4" type="ORF">CLCR_04270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIE9"/>
    <dbReference type="STRING" id="86049.A0A1C1CIE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04270"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08383"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF31">
        <property type="entry name" value="CHAIN DEHYDROGENASE_REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="305" mass="32819" checksum="F3FB3312098E05FB" modified="2016-11-02" version="1">MTSILAPADFAGLRGRSILVTGGASGLGLETVQLLASNGAYVTIADIQPPLDNLTREDQHVQYVHCDVSDWASQVAAFKAAIQFSPTRSLDAVATFAAVDPLENLIDQVKAVKDVSLDIDPAPPSLRTIDINLRGSYYSATLALHYFRLEPQSPASSNPQTKGLVFVSSLAGYLDDDHNIAYTTSKFGTRGLFRALRRRTNADFSPGVRVNLIAPWAIRTPMTEPLLKVMEESAGPVQGITFAKKETCAEAVGTCVVDESIHGRAFAIMPEGVFDIKDDITGGYGGEELKVLMSWRKAAGDFLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIR7</accession>
    <name>A0A1C1CIR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04078"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08529"/>
    <dbReference type="eggNOG" id="ENOG502T797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4157772at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="458" mass="52146" checksum="56EB408161C8DC27" modified="2016-11-02" version="1">MAQPHPTEAGSLQDLYLALSSLFDQHVVPIGDHLQTGMAQTLSAISSLKHETDAGRSSLESRIESLANILNATKSLANHFEPTSHGQNEHTEHSIADYASLEQRCNTFRDESERLATQNEQLTQRLEAEQQRVRDLEMNQQLCKAKLSRLQAVITKAATNANEVIDPEVTAKVQRIRARIETLVKKYCVGSRAAPRREHKELEEIDNDWVRKLKQIPTRYEQSDQDVFLTYWVRSKVYLLLQRRIFSQPCFGLDKDLESKLGEFETLISKFAHGTHPVEASKVPNCDTDNTDLETLGKNTSDWRALTLGYCKALGMTNDDTPKNVSQYIAHLFAPWVIGRPENQVGQKPVTYRWPPHLLHDLHDLCRDAYDLTVMIRQSTDRYRFISIDEDSKVRSADQDDFQPDDMLGPTDKYVGSKVWMTVFGALIKETQAGERYVMEKARVICKAAPPLSDHPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJE8</accession>
    <name>A0A1C1CJE8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SAH1</name>
        <name evidence="14" type="ORF">CLCR_04887</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJE8"/>
    <dbReference type="STRING" id="86049.A0A1C1CJE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04887"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03238"/>
    <dbReference type="eggNOG" id="KOG1370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="197"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="163"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="228"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="305"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT48654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="452" mass="49076" checksum="D57C72683CE4E071" modified="2016-11-02" version="1">MASNGAPAQKFKVADISLAAFGRREIELAEIEMPGLMAIRTKYAADQPLAGARIAGCLHMTIQTAVLIETLKALGAEVTWSSCNIFSTQDHAAAAIAAGGTPVFAWKGETEEEYEWCLEQQLKAFPSGKSLNLILDDGGDLTALVHNKYPEMLKDCYGVSEETTTGVHHLYRMLKGKSLLIPAVNVNDSVTKSKFDNLYGCRESLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQALHSMGARVLVTEVDPINALQAAVSGYQVVTMDDAASQGQIFVTTTGCRDIIVGKHFEQMRNDAIVCNIGHFDIEIDVAWLKKNAKSVQNIKPQVDRYTMPSGRNIILLAEGRLVNLGCATGHSSFVMSCSFSNQVLAQIMLFKAEDEAFGKKYIEFGKSGKKDIGVYVLPKILDEQVALLHLDHVNAKLTKLTPVQAEYLGLTVEGPYKSDIYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJP1</accession>
    <name>A0A1C1CJP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05282"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="104" mass="11405" checksum="41B0076D9CA3097E" modified="2016-11-02" version="1">MAVSRDRIAMSRLVEGRKIAWFQSAECAMSMASIEFDLGPQIYARRSPSRGSSTMARNFAPLSVSSVPPIIAFWELTVLHSSWLAVGICAKELFQRVPLACATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJS9</accession>
    <name>A0A1C1CJS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_11304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJS9"/>
    <dbReference type="STRING" id="86049.A0A1C1CJS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11304"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03196"/>
    <dbReference type="eggNOG" id="ENOG502RJY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="734" mass="82399" checksum="DA8EDD251D207C18" modified="2016-11-02" version="1">MASRRDSLLSVRSPKQRKYSTDRHQRQARLSIALEEGRSLRPPLAKDDEVSKSFLKDVFSQPQSTTFTQADTFPCPLEVHPGKRVRGFSSSAEDATELESLGFKNPFAEPNEAQQLDIEQRGAVIRRANTDIDAEEAHLRITRSASNARVRANRPLDRLRRWAGINSTIRPGAFTGLEYAAGFATTYATAILSQNAALVYKRKAMYVLEYDLDDRRVLLCGPPKRCETVAKLRKYLEEDSKQDSLLRLVYVCNNEEAINYLSGAFGISSSSAETEERSFRDWMQDDRDLRRASHKAIRWRPAFDMARGVICTAFGLDFGSLVVGPSPAQTQNHSHHHHHHHHHNQNQNQNQNRVGNASLYRQRIAVYMQRAFSGALPGPRVTRFNSGSRHLPDMARSDTVIICEYSSGEAGEIVSGNVLLGLYPDRERAPSRNATSIPTLQAVLSHVVDGLYQLWRDQIALIHEPHALLEDHIYAHPSDSSCAPDVWAMSQRLHNMLKLVNRHSKVVEAVQDDFAIFSEGEHGYERNYDDAIGTGIGTGIGTGTGTGASTGTSSNKWLTPLLDDFEMLAENIVTDYLQPLEHMIDLSLELNASLWRLSWITFIFLPLTFLVGAFGMNVDAFEHYPSLKWYFVAAVPLSLASNLCPVHDHGDFLLVRHAPVRAGPSPQVERFGRHGVGRRVGYTLFIAGEDVMSMSMPMSMPMPNYGCVYAYAYAYAYVYAYVYAYVYAYVYAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKW8</accession>
    <name>A0A1C1CKW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nahG</name>
        <name evidence="5" type="ORF">CLCR_04848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKW8"/>
    <dbReference type="STRING" id="86049.A0A1C1CKW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04848"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02780"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="19"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT49146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="434" mass="47610" checksum="5DA5D6E4BA958525" modified="2016-11-02" version="1">MPAAKEDHAPTSNAGSDFRIAIVGGGIGGLSVALSIGTYCPGLTARNVTVYEQAPAYTEIGAGISIGISAGRVLKKLGVWEAVDAISGYRTNVHRSNRRWDTDELIVDAPAFNTGGSQEEVRQLWLHRAEFLDVLYSEVKRRNCATLETDKRVVRLEDHGSTVTLHFADGTTAAADLVIGCDGIHSAVRSQFVVDQPVYSGRIAFRGIIPMSAVADDWPYSSWTLSWLAPGKHFLAFGMSQNRLMNVVAFVAKPESELQGLKESWRSEAPREAIEKEYAGWCPTVQRIIQAMPETISQWKINDREVLSQWVYMDGKVVLSGDAAHAMLPMQGSGAGLSIEDANVLGFAVRDYLSKPGAGLDKYMLKYQTARVHRAQKAQVTSRQAAAVYDMHGPDFEGKTFEECLPVVRDKVESRMAWLWKSDLEADWAAAGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKX5</accession>
    <name>A0A1C1CKX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_04725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKX5"/>
    <dbReference type="STRING" id="86049.A0A1C1CKX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04725"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02786"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="41"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT49139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="474" mass="51292" checksum="8858483F3119BD5A" modified="2016-11-02" version="1">MADNKEAIGEAPPAPDFIVDWDGDNDPENPLNWPSRRKAANIALLSCLTFVTPLASSMFAPGIPSVMEDFNSSSVILAAFVVSVYLIGYAFGPLVCAPMSEIYGRWPVYQVTNVLFIIFTIACAVAPSLDSLIGFRFLAGAAGSAPLVLGGGSVADMYPREERGSKMAVFSIGPLIGPVAGPVAGAFLSQDVGWRWVFWVITIAAGIVTILCLLFMKESYAPVLLERKTAKLRKSTGNLQYRSRMSSGDDPRTALVKALIRPTKMFLLSPIVFIFVIYVSIIYGYLYLLFTTITEIYEVTYGFNTGMAGLSYLGIGVGMFLGLGIFGATSDKRIQAKKAKGDVSPEIRLEGLIPAAICIPVGLFWYGWSAEKQIHWIMPIIGTGWVGLGLIGIFTYLVDCYPLFAASVTAANTVVRSLTGAFLPLAGRPLYSSLGLGWGNSVLGFIALAMVPLPFVFMKFGARLRTHPRFQVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL65</accession>
    <name>A0A1C1CL65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin unc44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_04973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL65"/>
    <dbReference type="STRING" id="86049.A0A1C1CL65"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04973"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02706"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="366" mass="40702" checksum="3A044A819BDE9D88" modified="2016-11-02" version="1">MKAAYSCDSSRNTSSLSLRLDVISRFGVHFEFSGWIPGFRIDRVMLDFRYVVPEDDPFMVACATGDVDLVRQLLLKYPASPRYRDTSEQSPLGVAIAAGHGHICKLLIDNGAKVDSTFGMYHTSTLSCALRHRNLEITRLLIAEGAQFDHTNAWGWSPVFYLWSDTVRRQEQASALIDLLRSQSEVEWQSLHRAVVDDAGWTVLARCAVFGNPEDMLTLIRYGVDPGEGPPASGWTALHFVVQHGVEEAFFSLFPWFRDHGDVDLPDFAGWTLLHLAVESGNPNIIRHLLQNGADWRARTLPSYNEDIPKSLRGISASTVEIAASCGDQRYVDFLDILDELGVLDDEAEDAAGDEDVWSDAVVAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLH8</accession>
    <name>A0A1C1CLH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-hydroxyaverantin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">adhA</name>
        <name evidence="3" type="ORF">CLCR_04977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLH8"/>
    <dbReference type="STRING" id="86049.A0A1C1CLH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04977"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03287"/>
    <dbReference type="eggNOG" id="KOG4169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF31">
        <property type="entry name" value="CHAIN DEHYDROGENASE_REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="262" mass="28940" checksum="601D388C570E8AE8" modified="2016-11-02" version="1">MIGDIDEARAAELTTAYPGRVWSTHCDVTNWDDQARMFQETIKKSPNGRVDVVVANAGISGQDPVFVDEESESEPTKPNLKILDINLIGVMYTIKLALFYFRKQFKSGVDTSTTAGPDTCLVLQGSLAGYVDQPGSPQYNASKFGLRGTMRCLRRTALQHGTRINYIAPWYIKTDIISDAVAKRITDKGAVFASIDDAAEALVRIASDTTVHGRSLGIVPRMWAPLGYVDVDHDDSREGDFLKEWQEIVLKTSHRLTGKSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLJ1</accession>
    <name>A0A1C1CLJ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLJ1"/>
    <dbReference type="STRING" id="86049.A0A1C1CLJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04567"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03312"/>
    <dbReference type="OrthoDB" id="3557394at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="313"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="912" mass="100633" checksum="C533BDA90E3A9F7C" modified="2016-11-02" version="1">MSSIFSHVLRSVQDQLAASGAPARSQYRTSSTSTPTAGYVPAQNFQALANGFSGPLMGPVYGASPAQNQYGTSSTSSPTAGYVPTQNFQALANSFSGLLLGPVYGASPAQNQYGTSSASSPTASYVPPQNFQAAATNSFSGQFLGPLYGPLYGASPAQTGYPPYQYPRPSSASQYLQPLIQPAAATAAAWNSPWLQYPLRPLSAPPVKEIWPTTNPTRTQIPERPSSSNQGYVTDPLITGFKKLAINVQPSAYPCGGNDHDADAEPRYHSFRLTPLLPTGDSFRLVEFSPVPTPQSPISCKLHRVSLRNHPEYIALSYPVSVSKISGRFRRLEQIACDDGYIELYGGMLDILYSVLNRHDPMYMWIDCCCMSQHDPDEKADQIAMMKHIYRKAKETVIWLEEPSDNALLVSQAFETLKIGYTHFNNIETRQAFASKWASTFEIVNTLALNQLLQKVYFSRSWMLQEAALSSHAVIHCCTYRIKWAAFCEQLACLMRIGYIEMVMTSYASALTANEVWLWLGRHKAFVTLWQELEKQRRRRVAPTEPLPLKLKQLMRLTRGMNASDLRDRVYALLGLCSDSGAIRVDARPQYTVAMLYHQLALYFTKSQSSSCNCDGSACPDNELSFIGDAGDLAAGSTDFSRLLTKGTGPVLTPSLHGCPAGYKAGGRTKPAVWYDPHVALPHSLFATGIITSRIQYITAPWPTFDDHPEVLELDAISRLLRCVQIMGGWFREAFGLVQQRIPPHHSRTEDFCRTLCGNISHMEADFLPSEAPRVPISNPRELERFFGDCMEVYQLLESYNYHFNGDTVTQGTALASHLEGATKWWELTGFTLPYAKFFLSDDGSMGVGPSLSQVGDRIAVFNGTPMPAVLRSADQGTGEQYQLVGPAYVHGLMDGEAYQVFPARETSICLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM12</accession>
    <name>A0A1C1CM12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_07430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM12"/>
    <dbReference type="STRING" id="86049.A0A1C1CM12"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07430"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09756"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="209"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT49492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="315" mass="34261" checksum="2B8B814FCE7A9B3E" modified="2016-11-02" version="1">MARPDDTLAAAAAILRGFARGSTASAYTNGLKLPPYKLPGDDTPSKEDFEAEIAALARRIHYLESRADVVGRSLPDTPGEFQSPTSPLGRPAEPRGSLGDTGTDLSADSTERAASNGTQSRRVNNLLAARESLPLSTSDRTVSEDDISILREHVERQAEQIKSQRDTIAEISRGLRNSEEQAKQAFMRVENEDVSILERELRKHQQANEAFQKALREIGGIITQVANGDLSKRVQIQATEMDDEIAAFKVTINTMMDQLEIFGSEVTRVAREVGTEGILGGQAQISGVHGIWKELTDNGITLDSCLSMAVTDTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM22</accession>
    <name>A0A1C1CM22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-catenin-like protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM22"/>
    <dbReference type="STRING" id="86049.A0A1C1CM22"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06902"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09818"/>
    <dbReference type="eggNOG" id="KOG2734">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1898821at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001136">
        <property type="entry name" value="Beta-catenin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="7">
        <location>
            <begin position="106"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="609" mass="67080" checksum="435D98F9A170A14A" modified="2016-11-02" version="1">MASIDDLFRKPNVLPKRKLEDPTKSFSNALSNKSAKLAEGSSPRSSTNGSHDATTSDASNGRAASVQDEPIDDQDAVEAGPALPSADVEDDAGDDEEGRFFGGGVTKQEREVIDYIDKNESGEVEEKIDSAWLRRTAINFERKINKNAELRAKYEGDPMKFVGSEADLDAEIKGLSLLSEHGELYAEFVKIGSAGSLVGMLAHENTDIAISACELLAELTDEDSSTTEEQWNTLVKALIKADVVDLLFSNLGRLDESTEADRAGVYHILNVLENIMSDTENLEIVGANNAVLEWLLSRIKKPDPEARAKVGQNRQYAAEILAILLQSNKRNRDRLAQKEGVDALLELVSAYRKRDPEKDSDEEEFAENLFDCLACVVEERFAGEKFVEGEGVELCLIMLREGRLAKARALRVLDHALSGGNATAVSIRLVDAAGLKTVFGMLMKGHKMERSLVEHIIGILASLLRYLPGGSAERIRILAKFVENDYEKITKLVELRREYKARLSKVDADIRRDREGLSKAEAEARADEWLSRRLDAGLFTLQAIELILSWMVAEDNGARQTITILLGEDGLKVLERSLKDQLEGMDPGGGDEAKATEEMLEALILCVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMR7</accession>
    <name>A0A1C1CMR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMR7"/>
    <dbReference type="STRING" id="86049.A0A1C1CMR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06637"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08727"/>
    <dbReference type="eggNOG" id="ENOG502QT51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="759"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="913" mass="101248" checksum="8FCAD7769464BADC" modified="2016-11-02" version="1">MQRLFKTNKSQASIEDPQAHQAHPDPHLHQQQQQPPPGGRQQQLYFDPQHQPYSRQQSQQQPFPPDSRFSGQGQGQDLHHQSQSQPDSGAPPHLNRSQSNRNSSIPDVYGPQRPQVNVVPPLSQQHDAFVPEGPAPVPGQTQFGRSTQVRTVEDKEHKRSKRNIISSLLKDKSKDDERHREKEKENNSVERKPLGRSSSVHLLRKSHPPPEQPARESYSTQTSPQSQYPSRQSVYYPPPPTEATDPRASQAADQTTYEQYQRNQAQFDSPQSQFTHHSIEYTEDAPHFSPQQEQYQAYHQSESENTSDQYLPYQPQSSRPGNVDSDHYQHLRPPSQTSLGPPSPINTPAQPQTGGPDSRPSTAATNRYSAQSPPQGQQPPPSVMARGDPPNGGIRQQLSQRERGSDEQVQYQSQNQADPRARMSQQQASEQGRNTPPPRSREDITQLDFASLLARHEELQAKYSKVKRYYFEREAQVTQLQNTVANQRLSMSKTSLDDAQYTARFERLSQAINNLSFNIRKNWRAIPPWLRHVCNQDAHTVGTKEMTAVGRACITRWLYESIFQHTFHPGIEPSLSAQLKRIEHNLRRGGQAGAMLTDEQRDDLTTKITTWRLTTIEGLHDMLGSQQAEHYTETMNKHYTHQLTESLKANLTDPPPPGLVEGVGMIVGQAIGIASNIPLESRDICIEYFMPGTPLNEAYMKVEPQIVALTNPGPDERILQQQAAEAKARAEAQEADQMSTASTDDGPRDVEAEIREAAGKAASQTAQQSGQQGRNESVASNASQATVKGSGDKQSKKSGLFGGFVNKKPSMSSRGGDRPEVANINSARAEGDDERGNVRNSMAVDPASMVPPSVANEGRIRFAAFVAVEVRGKGPGMAPTSSAASGKEPGSTATAASPQSSVNVLFKAPVYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMZ9</accession>
    <name>A0A1C1CMZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxysterol-binding protein-like protein OBPa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">OBPA</name>
        <name evidence="7" type="ORF">CLCR_06885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMZ9"/>
    <dbReference type="STRING" id="86049.A0A1C1CMZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06885"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08780"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000007">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT49859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="533" mass="59965" checksum="407EB8CF5AFBF0A9" modified="2016-11-02" version="1">MGDDCQQADSKNLGNRSSSEEQREPVDEDTTVVEPDQGNVLSHIISQLRPGADLSRVTLPTFILEERSMLERITNFMAHPDTLLPMPQIEDPVDRFVSVIKFYLSGWHIRPPGVKKPLNPILGETFTCYWEYPDNTRGYYISEQTSHHPPKSSYFFMAPEHHIRVDGTLKPRSKFLGNSAASMMEGISYLRFTNRGKSKGGEKYILTQPNMYARGILFGKMKYELGDHSFVRCPENGLAADIEFKTKGWVGGTYNAIGGVIKNEKTGETLFELSGFWSGEMTIKDTKTGQKKVLFDATHAKHAPPLARPIEEQGERESQRLWRSTVQAVHARDHEVATTEKAKIEDRQREEAKRREELGVEWKPKLFRRVDSRPGGTEEGEEDLEWIINAHLDPNASPQELVEKILSIAPILPGQGAPTEREPKHQSQPATESQAPAAQKNAGEHLQASGNLIDFDSRPPSTVPPESQPNQTSSNHQQPVRRNDANLMDDDEHLSNQISKLKMHEAMVPEGQKPLKRTDTDTSEVDVFVDAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN22</accession>
    <name>A0A1C1CN22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_07454</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN22"/>
    <dbReference type="STRING" id="86049.A0A1C1CN22"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07454"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08773"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT49851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="298" mass="31680" checksum="DE2F87AA57A009B2" modified="2016-11-02" version="1">MTTPHPRVGVAVFILHLVDVDTDIKHITNQKQTQTQTQTESQSPVSPSPPHERYKFILGQRLGSHGAGTWALPGGHLEFGESFEDCAAREVMEETGLEVEDVKFLTATNDVMLSEEGGGAAGAAAGATSALDGQNQGKHYVTIFMTARVRSGWHAQAQGQGQGQGQSMSLGTNTNTNTNTATNAGTRTSTGQSTGTGQQFPEAKLLEPDKCAGWEWVSWHDLLTWAAPQLGGLQEEKKKKKKKKKKGAAPRDADTEAEAGAEAEAEADLGAPPNDSRTLFSPIIALLVQRPDAVPSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN34</accession>
    <name>A0A1C1CN34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfite efflux pump SSU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SSU1</name>
        <name evidence="12" type="ORF">CLCR_07071</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Sulphite efflux pump required for the secretion of sulphite as a reducing agent. In the presence of sulphite, cystine in keratin is directly cleaved to cysteine and S-sulphocysteine, and thereby, reduced proteins become accessible to hydrolysis by a variety of secreted endo- and exoproteases. Excretion of sulphite mediated by an efflux pump also represents a detoxification pathway for dermatophytes during infection of the epidermal stratum corneum, hair and nails, which are rich in cysteine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN34"/>
    <dbReference type="STRING" id="86049.A0A1C1CN34"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07071"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08827"/>
    <dbReference type="eggNOG" id="ENOG502QT02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.150:FF:000004">
        <property type="entry name" value="Malic acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF2">
        <property type="entry name" value="C4-DICARBOXYLATE TRANSPORTER_MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT49910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="488" mass="53674" checksum="040ED8F041569B0A" modified="2016-11-02" version="1">MAYLAEDDETLMQRMASNNPAMTMAAPSQMATRSDFSASRLGRSNTTATSQSLARRITSRSDPAGDGLSPITTGDSAEEGKSSPADADTDMSTSKYDVGWRRVVRNFSPSWFSVTMGTGICSLLLITIPWKAAWLYWLSVAFFILNSILFSLAFIISFLRYTLYPEIWHVMIKDPTMSLFLGTFPMGFATLVESWIFLCCPYWGYWSVWVAWLAWMLDVVIAVAVTVSLPFLLMSQSDNHGLERITAAQLLPIAATIVASGTGSEVAELLSSPDHAFGTILASYVLWGLATPLSMTVLVMYYQRLALHKLPPREVVVSSFLPIGPLGMGGYTIMYLGKVSREVFPRVELFHDLLIAGDIVYVLGVFIGLIMWGFGLCWLIFAVATIYSTRPFPFNMGWWGFTFPLGVYAISTMTFGVEFPSMFFKVFGTILSVAVILLWCVVATGTAKGAWSGDLFYAVCLKNLPPKRANGDGKTGATVVDKEKLPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNA3</accession>
    <name>A0A1C1CNA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative isopenicillin N synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_07249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNA3"/>
    <dbReference type="STRING" id="86049.A0A1C1CNA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07249"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08888"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="169"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT49977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="388" mass="43223" checksum="15C195C6C624D833" modified="2016-11-02" version="1">MSFSSIPILDLSLARDPATKPQLLDELRHALLEVGFLYIKNTGIPESLINEVISLGKAFFDLPEEKKLEIEMKNAPSFLGYNKLGMEITRFKTDWREQIDLSTPHPVPGPNDPLYRNLLAPNLWPDPNALPGFREVYEEYMAKMGDMSMEFTSLIAEAIGLPKDAFAQFFDDAQQHKLKIVKYPDLEELGVEGEAQGVGPHKDSMLTSYLLQASHHRGLQVQNAEGQWVDCPPIDGTFVVAIGQGMEALTQGVCQSTTHRVQSPVRGSGARYSIPFFQGVSYDATFESMDVPDSVKKLRADILEKRGGQRLDDIEFTFIKGMWSRLGEATLMNRIKSHPDVGERWYPELLKKIRADQAEEAAKFAAAENAASTTSTPLPSQPQSISAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNN5</accession>
    <name>A0A1C1CNN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hydroxyquinol 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">npcC</name>
        <name evidence="9" type="ORF">CLCR_07240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNN5"/>
    <dbReference type="STRING" id="86049.A0A1C1CNN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07240"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08987"/>
    <dbReference type="eggNOG" id="ENOG502QWDJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="112"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="329" mass="36692" checksum="C41397341A175557" modified="2016-11-02" version="1">MDPSKVDIPPLKDLTIDNITENVIAINSNNPDPRFKYILERLVVHLHDFARETRLSTQEWMAGIQFLTKTGQICTDVRQEFILLSDILGLSLLVDSIDHPKPPNSTEGTVLGPFHTHEAEVLSHGDLMSHDENGDPLLVLCTVKDVQGRPIEGVKIDIWETDSSGKYDVQHPDRDGPDGRCVLKSDAEGVFWFKAIVPVPYPIPHDGPVGQLLKKLGRHPMRPSHMHFMFEKEGFDHLITALYLKNDPYETSDAVFGVKNSLIVELSTVSADQAAKYGVKEGSALMTYDFVLVTEQESADLRAQNSRTALEKLGRRVKIVKGLPVPDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP78</accession>
    <name>A0A1C1CP78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06762</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP78"/>
    <dbReference type="STRING" id="86049.A0A1C1CP78"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06762"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05677"/>
    <dbReference type="eggNOG" id="ENOG502SAFQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21589at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="606"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="663"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="692" mass="75026" checksum="7F9EA68CD3C734CA" modified="2016-11-02" version="1">MDSSSPSPPPQGQPQLERDHVNLRVTYLVTGNPRPPHSLGSVHLNTTIAELRTKIQSELPEHPAPTEQRLIYQGRPLLRNEVTLRDVLRIEPGQDAGPLPFTIHIVIQSPQPAPQPPPPAPLPAMHQNHHQHPHADVTNPFRAAEHSANRLQESLVRIQEQIEANRADLRSVQQRIALQHTNLGGPPMAAHVHVNGQPLPNILPPGFPMNLPFGLPLEPPPQMQRPPTRTPHHPRQPSNTPPGQHPATGGTSTPNAAQQNGPGPYPQRVTVVTETVSIQNQAHRPSSAPGQRPPVPSQQRGNVPSHTPHADSSTPAPVLPPPGWNYSTSATLPPLPIPRPFAQPLVTTLHPSTATAWLMSSPSGPRALLFAPGHGYFSSVSPVTAQPQQAAGAPNSETRTRNTNSMPVPGPNQPGDLEQQGADRAVVRADQFQPAAALAQAQQNGPENDLFAFFINRGWLFLRLYLFMFVFSEPGTWKRWLMIILAAIVCLQPRDGPLTRLLRAARRHFDALVGPPPRPGAVAQPRADVAGQPLLAGARNEAPAQRPANVRGAVQMTPEEAAARIVAGRQNNQDRPPRFWRDTFYRVEQSMALFLASLIPGVGERHVRAREEQRREEERRRAEAAAAAAAAAAAAAAENQNLPPEEAQVNGPDRQPAVDKSEVNPSGNGEQSTSSSVQARQEAGAGELRDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPV8</accession>
    <name>A0A1C1CPV8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidophosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADE4</name>
        <name evidence="11" type="ORF">CLCR_06935</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPV8"/>
    <dbReference type="STRING" id="86049.A0A1C1CPV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06935"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05464"/>
    <dbReference type="eggNOG" id="KOG0572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191723at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046083">
        <property type="term" value="P:adenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012610714" description="amidophosphoribosyltransferase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="2"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="550"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT50547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="593" mass="64981" checksum="FA39B73EEB8BBD99" modified="2016-11-02" version="1">MCGILALILANTASADVALDLHEALYLLQHRGQDACGIATCVAGGRIYQCKGNGMAAKVFDNGSRTLDLPGFMGVGHLRYPTAGSSANAEAQPFYVNSPYGISLAHNGNLINAPELQRYLDLEAHRHINTDSDSELMLNIFASELNETGKARINKDDVFAALGRMYEKCKGGWACTAMIAGYGLIGFRDHFGIRPLVLGARDSADGIGKDYMMASESVALTQLGFSVVRDILPGEAVLIEKGQEPHFRQVQQRKTYAPDIFEYVYFARPDSIMDGISVHRSRQHMGVRLAAQVKKVLSPKDLAEIDVVIPIPETSVTSAAVVAKMLDKEYVQGFVKNRYVFRTFIMPEQKTRQKSVRRKLNPMPMEFKDRNVLLVDDSIVRGTTSREIVTMAREAGAKKVHFASCAPPITHAHIYGIDLASPFELVAHNYHGAEAIAKHIGADSVIYQTLDDLKAACVDAAREAQAVDAPNDFEVGVFCGTYITPVDQGYFEHLEQIRGQTRKFKVVDEARRAVVQGVAEEHQIQLATNGAVVTPNGEVVPAVNGVRKQSVHTDLRDSHRGSAASLGPDEDSPTVRDRMDIALHNLGDFPRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPY5</accession>
    <name>A0A1C1CPY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5 6">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tit1</name>
        <name evidence="10" type="ORF">CLCR_07109</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5 6"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPY5"/>
    <dbReference type="STRING" id="86049.A0A1C1CPY5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07109"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05468"/>
    <dbReference type="eggNOG" id="KOG1384">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030666">
        <property type="entry name" value="IPP_transferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039110">
        <property type="entry name" value="IPP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT50542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="463" mass="52140" checksum="C89127BAF6503919" modified="2016-11-02" version="1">MASSPPKDPLIMVIGATGTGKSKLAVELATRFNGEIINCDAMQMYKGLPIITNKIPENERDGIPHHLLDFIDLREKPWSVQHFVRESSRIIDAIRARGKLPIIVGGTIYYTFSLLFNDAILSTADGDSGDDSLIESADKAGDDMAILSAPTEEIFAKLREVDPEMAQRWHPNDRNKIRRSLEIYLKSGRKASDIYAEQRQPIVEDQDGKDAVNTRPTRDNATAERKMSLRYSSLVLWLEAEDAVLKQRLDARVDAMVADGLCGEVVQMAKFESELRNQGQSVDLTNGIWASIGYKEMKPWLKEQQASDIDSARLVAAKEEGIEAVKASTRRYAKRQNRFVRIRLAKSLKAAGRYELLYLLDCTDLARWPAVVGEPAEALVEAFVQGRELPRAKTLSDMAENTLVRIEQDSMVGDRQARICEVCNKTLMTEKEWNGHLTSRSHKKITAWRRRQELLSVQESRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR51</accession>
    <name>A0A1C1CR51_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carboxylic acid transporter protein like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">JEN1</name>
        <name evidence="7" type="ORF">CLCR_08429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR51"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08429"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09626"/>
    <dbReference type="eggNOG" id="ENOG502QPK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000190">
        <property type="entry name" value="Sugar transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="65"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT50987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="503" mass="55085" checksum="E2D6B2840C36549A" modified="2016-11-02" version="1">MASLDEEKVDVAFVERSTSLQDQSTVKMSTSKYLSTRFSTLKPTLTIPPNPIKLLGLLTRKNWLFFAVAMAGWTWDAFDFFTVSLTVTQLAAEFDKSNADITWGITLVLMVRSIGAIIFGLASDRYGRKWPFVFVNVLFIVLELGTGFCQTFRQFLACRALFGIAMGGLYGNAVATALEDCPLAARGIISGILQMGYILGYLLATVFARALVDTTSHGWRPLFWFGACPPVLIIAFRLTLPETETYLNRERVRKASKATVSTFAREFKLSFTNHWLLLVYMVLLTAGLNFQTHGTQDLYPLMLKSQYGFSANGVTITNVVANLGGFAGGVTCGWISDIFGRRATLIVTFLVSATLLYPYTFVSSRATAAAGFFEQFFIEGAMGVVPIHLLELSPGSLRTFSVGTAYQLGNLASSASSTIEATLGERFPLEPTAAGVKRYHYGKVICIFTACCLLYNILVVLIGPEKKGVSLNVEDDSDMKQAVGHEHVDEILAAKMQAGVQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRD4</accession>
    <name>A0A1C1CRD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Aminomethyltransferase</fullName>
            <ecNumber evidence="2 8">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 8">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">gcv1</name>
        <name evidence="12" type="ORF">CLCR_08486</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="2 8"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRD4"/>
    <dbReference type="STRING" id="86049.A0A1C1CRD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08486"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09690"/>
    <dbReference type="eggNOG" id="KOG2770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="10">
        <location>
            <begin position="92"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="11">
        <location>
            <begin position="406"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT51055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="495" mass="54300" checksum="5D456509D413C872" modified="2016-11-02" version="1">MPARQGMRPLLASVSRASKGPSTIPRRQLSFLITSSSPSHQRPTCRFPPEMIPIPLPVPKPGFPMVGGSRPSPQVRHASSTASSQELKRTPLYDLHVSLDAKMVPFASFSMPLQYPDLSHKESHLWTRQHASLFDVSHMVQHKLSGELAEEFLMTVTPSALKELEKHRSTLSCLLNEQGGIVDDTVISRIGKDGFYFVTNADCREKDLKFLDEQMGSFLKARGASKEKINWHVLDHHALLALQGPQAAEVLQALVFHDTEDEGLDTSLETLYFGSSRWVQLTLPESGMNTPSLLITRTGYTGEDGFEISIPPENGDATDLATNIAKALTADQSKVRWAGLGARDSLRLEAGMCLYGHDLNEQITPPMAALGWLVGKSRRGENPSPAFNGHETINKQLAAPKSMPERRVGLLIEKGPAAREGAEIVDLEHDNEVIGRITSGSPSPSLDGQNIAMGYIKNGLHKKGTQVGVKVRKNVRKAEVVKMPFVPSKFFTKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRR8</accession>
    <name>A0A1C1CRR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cdc3</name>
        <name evidence="7" type="ORF">CLCR_09125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the profilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRR8"/>
    <dbReference type="STRING" id="86049.A0A1C1CRR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09125"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06870"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000755">
        <property type="term" value="P:cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="147" mass="15736" checksum="A675ED25BD7B9922" modified="2016-11-02" version="1">MSWQAYVDTSLVGTGHVDRAAIFNAEGTSVWATSPNFQVTPAELQEIVGAYKDTSSPKKVQSTGLHIAGQKYIVIKADDTSLYGKKVGKRAAARRIGGDNERKGREGVVIVKTKQALLITHYPETVQPGTAANTVEKLGAYLVGVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRZ3</accession>
    <name>A0A1C1CRZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRZ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CRZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09210"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06825"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="150" mass="17592" checksum="F23FDAA7E623F128" modified="2016-11-02" version="1">MSPPTGPLCISLKFLKWLPLYEKEKPFQIFINIPEDATDKRTTNLAFENVKVTIEDVRSFPRNHFLLDKHGFTYHSHYLQLDHIADRESVEQRYLPAMESLLRSALESVDRVFFFDWRLRKNAPETEGALIDLNDLTTWLRPALHLHVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS97</accession>
    <name>A0A1C1CS97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS97"/>
    <dbReference type="STRING" id="86049.A0A1C1CS97"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08434"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06731"/>
    <dbReference type="eggNOG" id="ENOG502SBK0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="521" mass="57818" checksum="2AC6A5BB176F9AED" modified="2016-11-02" version="1">MTAARLSPAANLLRTSRLFSIPAAVSLPAVEPSSEPISYSDSATTPYPTRAAIETPLASLNQGDWGLKRPLPIKTTTKSGTPLVRFRRGIDTPEHVVDFESAADHVLTLRKYQELNLRVTLPAPRRKSVQDQQISPFEVELDHTADQLPPRLDQKTSISWLDQTPSERAQRIPGHLKDAMLKVEKDKGEMEKRLIQSQPTDSAPAPSVESLRRWRYSGPYLAGLNGLEFDAFLKTITREKRAAFRELVKNDLVEKRAHEQRLKALDEGQPDVSSQSADGITEEDVTEHMRYLRNEPGKFGPLIAKFFDLADGPNPSSDMSDPWSYGRDTIAADLYRESGPPRTHPSAGLSYLKTEASAANSPTTGPRASRDPVAARLLKSRQIMHNKHVPYVGVAGFVVPEPIGATAITEQVWKWEPVKDGPKLVVTPISTSVSQAGKVEIKTKRLQGWAVENDLPVDPTKRRTTTAATAPARRMSSQLPSLDSIAPRRTRPPPEPERDIDEELDLLKSMSSPKWTKRNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSH0</accession>
    <name>A0A1C1CSH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LEUA</name>
        <name evidence="21" type="ORF">CLCR_08056</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSH0"/>
    <dbReference type="STRING" id="86049.A0A1C1CSH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08056"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06651"/>
    <dbReference type="eggNOG" id="KOG0454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012235">
        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001418">
        <property type="entry name" value="ACN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 18" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="13"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="539"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OCT51431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="775" mass="84557" checksum="F6937604EFF40B4D" modified="2016-11-02" version="1">MPSIESKPRTLYDKVFQDHVVTEEADGTTLLYIDRHLVHEVTSPQAFEGLKNAKRKVRRPDCTLATTDHNVPTTPRKNFKNIAEFVKEDDSRLQCMTLEDNVKEFGLTYFGLGDKNQGIVHIIGPEQGFTLPGTTVVCGDSHTATHGAFGALAFGIGTSEVEHVLATQCLITKKSKNMRIQVDGQLAPGVSSKDVILHIIGVIGTAGGTGAVIEYSGSAIRGLSMEARMSICNMSIEAGARAGMIAPDQTTFDYLKGRPLAPKVDSNEWKKAIKYWSSLKSDEGAQYDLEVFIDAKDIAPTVSWGTSPQDVVPITGVVPGPDDFEDPNKKASCKRALEYMGLTAGTKMEDIELDKIFIGSCTNARIEDLRAAAKIVEGKKVAPNIKRAMVVPGSGNVKVQAEREGLDKIFEEAGFEWREAGCSMCLGMNPDILSPRERCASTSNRNFEGRQGALGRTHLVSPVMAAAAAIVGKLADVRKLTDNATPVKASPKLDVAPEFAEVDSEEELDRILDIPTDATESSTNLHAEPKAAAGAGGLPKFTVLKGIAAPLDKANIDTDAIIPKQFLKTIKRTGLGSALFHPLRYNEDGSENPSFVLNQEPYRNSKILVVTGPNFGCGSSREHAPWALLDFGIKCVIAPSYADIFFNNTFKNGMLPLIMPDQQKLEKIADEARAGREIEVDLPNQVIRDADGHELAKFDVEEFRKHCLVEGLDDIGLTMQQEEAIRKFEEKRTLDTPWLDGSGYLKKWRKGPVKVEAAPVPKTNRGEVKTDPVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSJ7</accession>
    <name>A0A1C1CSJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08993</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSJ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CSJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08993"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06626"/>
    <dbReference type="OrthoDB" id="3145928at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="170" mass="19517" checksum="5F44BDF88695AEF9" modified="2016-11-02" version="1">MTESRLHACWQIWEGTLQIRVSNLQVVGDASATQSNAVLLPEVNLFAPQHNDDERWAFNYFLHRAAPIFAGVVDGPFWLDLVPRLAQSHAFVWNVVISSSWMFEHVQYSGLETAYTPCDTSTVTDKEHRKALKWYQRALVDFRRLLERGEADNGYILLSCILFAGLEFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSK0</accession>
    <name>A0A1C1CSK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_08979</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSK0"/>
    <dbReference type="STRING" id="86049.A0A1C1CSK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08979"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06627"/>
    <dbReference type="eggNOG" id="KOG3291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="75"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT51457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="234" mass="25960" checksum="126C2F81B52FF9BA" modified="2016-11-02" version="1">MSDNGEVEVENPVSSWPVLPKDVTAELGSIKLFNKWSYEDVEVRDISLTCAAVDFSRVDYIQIRSPVYISHSAGRYAAKRFRKAQCPIIERLTNSLMMNGRNNGKKLMAIRIVAHAFEIVGYAASKRRQIHIMTDQNPIQIAVDAIVNCGPREDSTRIGSAGTVRRQAVDVSPLRRVNQAIALLTIGAREAAFRNVKSIAECLAEELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTV6</accession>
    <name>A0A1C1CTV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTV6"/>
    <dbReference type="STRING" id="86049.A0A1C1CTV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09004"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06209"/>
    <dbReference type="eggNOG" id="ENOG502S6QN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5300823at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052841">
        <property type="entry name" value="PMP_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="262" mass="27960" checksum="A14203BC04A4BA36" modified="2016-11-02" version="1">MADAHNPPLNYEASSTTTNPQVATTLPPEVSQCLKNARFLHLATISATETSPATPHISLMNYTFLPSYNDHGPVIIMTTNAQSMKTQNLRHNPKVSILVHDWVSHRPPTASSVSGERAGSPPAAATRSSLASLLLNLNTSALSSISTTIAGEARFLEQGSEEEKWCKAAHLANNTFGEQVRQEAGFFGAPPQNPETENSSCYIEGDDVRVVVVPVREGRTADWKGGVKDWVLVEEAAPSASSEGGGERGRSNGQPSVNSIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU40</accession>
    <name>A0A1C1CU40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Noorani M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU40"/>
    <dbReference type="STRING" id="86049.A0A1C1CU40"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07911"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06136"/>
    <dbReference type="eggNOG" id="KOG4386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012880">
        <property type="entry name" value="Gryzun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07919">
        <property type="entry name" value="Gryzun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="2">
        <location>
            <begin position="348"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Gryzun putative trafficking through Golgi" evidence="1">
        <location>
            <begin position="653"/>
            <end position="1261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1261" mass="138824" checksum="5B844DD35801786D" modified="2016-11-02" version="1">MDRFPQDYVGHNLPLLLLSGLNSRSPHEPDASGNTHEFLHEGGFRIKVDAPVVGGSLAEQVLQSFCDQDASEVPWHSQAFALRNAKVFKIATVGRVFTLPPRKAPPPPHSPRLSAVNANGSPPAPWLLHSPLSPLTPSSPLYPDGIVSPLWITKHQTRLPCAFLSFFSLGSDPNTSSLQDNRLKSEINNVRNVLSSTNYKTRHVVVLLGDGNISIPDLEDRLATIRRATALDSKSLYFLAHNSSPAQVVAFVNNVLSALHPLCIEYYRDLSKHARRKRNRSAIPQPTVQPGTSNILSLQGWNVRYEFKLGVFAEFRQEMDAACRNYETAYDSLFAPEIIDGIAAWSPRFDEARLLADVIALRTIRCLLWTDQGATAVRSWITHRDRTADLVNRRGKGTANYGWEAWQSAWAKTMADLLSRSEYPLLNLKLPNTPGLLPIYVSAERSLPMGERLTPWEQLHHQGYWLDSAKNSILARRKWALQIPEEDRQPPGRSPASIVASKAQLYDTYLALEPYREVPGDGSPGHDYAQEIATTLADAITCFRHRGQLRKIDTLKLQIAFQQIETQSWAAATSTLQELWFSQHWRQAGWWKLLQGLGWALLDTLARVENGELLVRLLWELTNEVFERKPNTNYDLRQALASYSLGNGSLSIAVDVDEALSPLTATFAFSTHDVFVGESLECQLAIQSRAQIDLPAIRLSEVKVVFDGSLKPIYLTAKDGEDAEVHNGASTTHFVDVNLHETPSTSSSGTKRSSTTAIAPQAGNANLSIRSSHTKIFRMRVTPREPGDVSVASITLILNDQKFTLAATCFDFSHTVAQWWETKEGMPVPRTLGRESNAFNTIHIQPKPPKLKLEAPGLRRSYYTNESITIDFDITNEEADDVLVVLEARLISPIEGATQVDWAGKGTDTASATRSALGIMTLPAREMGTILSSDKASAAIRITGTTIAVDHELELTATYRLVSEQETTLAKMITVDVGVIRPFEANYDFAPRLDTDPWPNFFEAPQPSTETATPLGLRHLYSVAASLYSFAAEGLVIEAILLTATKIVGGAVCSSGTGIIRSKAESGAAAAAAAAEQTGKEIISTVIMPDQTEIFDFDLTLQKLVLGDRHTVAVDLELEIAWRRNDSDEVNTTVLEAARLVAPMAEPRVILTASPPGLGVPGAGVYTLSFTIENSSMHFLTFNASMEANEDFAFSGPKACAINLVPLSKQTLTYRILPNKRDEWIGVRLNVVDAYFGQTLKVLPGGKDVKVDKQGNLLVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU68</accession>
    <name>A0A1C1CU68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endosomal peripheral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_07883</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU68"/>
    <dbReference type="STRING" id="86049.A0A1C1CU68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07883"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06098"/>
    <dbReference type="eggNOG" id="KOG1848">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="4">
        <location>
            <begin position="200"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="474"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="609"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1580"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1672"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1672"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1698"/>
            <end position="1711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT52033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1776" mass="195329" checksum="D4FCA7480CB2BF36" modified="2016-11-02" version="1">MTHAFLQSELTSLISDSKRKYNDVRAAAERALGDIKAISVTSETQLAGDLCRKPQFVDPFILACKSKNARLVTTGTACLHRLTASRAVPRTRLPDVLDAFQDAIGAGYEPQLKVLQTLPSLLQLYVDDIRGEILARILELCAVLQSSKTAVVSNTAAATFQQLVSTVFENGERKDRPRTSGESETPTPTDRYQGGEFSVDAVALFEDFCLLLDQQKPRFLRIENLPSAFLLETLHTILASHDSLLKSEKEPETKWSERLLHGLSRSLVRKDNFGITVRALSILLLIFRTHGEGLQHEVAEVVPLLVGALEKDGNPPWRRSLYLEFFRSLFSDFNVLRETFAIFDSGEEPVKLVGQVMSALVRIGAEDPSLIGLGRQSTVPIQRTNDPKSDEAASIEAQGLGGAITAVASNDSNTTGLSAEWSLIAVPLMEQPDKTVAPAIPSTYIYTLVLDCVSSFCDGLSKFVMPLSVPSRASQWENSEVGRRDSSATDRTDDEPSRRPTRPAPSSHKYQRLINPLTLANHRLSAQIRTSADMIEACWPAALATCSTFLNSAMDAEFYHALIRSVQKLAQVSGVLELSTPRDALLTTLAKASIPANASSIIASSQTAKNSRVGGAEHSDVSNGLKSPTDPPPTPTFQGNSSPLNVRHLLCLRALLNLGIALGPTLKRDAWFILIETMQTVEALIAMPTTSAATSQSGSPRIGASGNDGHTTLATEIAAVQAATKRMLESTRSFGADSFTEIVQALLRLLGQNVEVVNSKSVEQPIASPTTPGRLGARPGHQASRSVSGLWTKSKTLELEVGFVLSKLSDLSRINLYRFASSTEQACSWILIGDRLLRLSRDTMIAANYRIQAASILDLISMETVKLLDDSRFEAAEADAIRLQCLRSLLQQLDSFEDTQGGKHDEVELEIHKRLLDALESMLSHSGESLSNCWPIALEILSVTSSKRGKNKPELGNATIEQAEKDAQTAQILRVAFRSIQLIASDFLDVLDSKTLANLAYLLRQFGSQQYDLNVALTSTTVLWSLASHVLTKIDRIDIETMPNLNDGDEELLSQTVLRSGGIWSSILLELVGLCKDERADVRNAAIRVLLKMLDASSEHLSSSTWAISLRLGPFETIRYCIRQYAANKTDQEPWMASAAQLTDGCTQLLCHNLNAIAQHDGFRDTWLRIMDVLKSILDTNSVSASSLAFSNLSKLLSALADLPNSSEELVQPAVQLWATYHPGDIRHEYPSDGQPSDEPSNQQAFSAHAHVLVEAYKTSSVAISKYLQGQTSTLMDSIERGVMLCTHPPYTSDVKTLAPEQKEASDCLAILKILLQDDVSKYAEFLLRLVTLTLNIQNGKVVVQQKKSTLSKSMQRPSFIAFTAACLDKFRDLILECADDDNFIQTVAVRNACPVLSAVVSTKYTRMPTNNEMPLWRKATVIAAVMLEALQKHVRRGSSKDLSQLESMAPPIISIAVSILQPGDLSNPPGPEHKEATILEDETFDIEHFELLHKAIVPIFQNVEAIKGDACKQYAIVLFKASLLAKPWFYDLPDDLASEPLKDLMRVRPGSVHRPVFAVRRQICHAALRALFDLVERPQHARAGEDERENTTPTPHPGPMSQHKLASAAAPYLILRVVHPLKTFLADQRLRSLTPPPMAQQVELQVILSKFVDLRSNGHAVADMMMMLSSSPRAAQTETRTQGDLDPRTRGNHPSPSEDDDDDDDDDDDDGKEHLRVLYGLMLRVHTFWQALPRLKGPGARAWQDDEPGRGIQDALERWQRLIAEGWAIAFAGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUD8</accession>
    <name>A0A1C1CUD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09361"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="80" mass="8449" checksum="D871B3AB23AFFE35" modified="2016-11-02" version="1">MPRVIYGPSPDAALMQSAASLSSAKIIALTPSHTWSTAIMKHETGDSTSESRHEDIPFPSLDLSVALSLAATTRDAPARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUS4</accession>
    <name>A0A1C1CUS4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUS4"/>
    <dbReference type="STRING" id="86049.A0A1C1CUS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08972"/>
    <dbReference type="OrthoDB" id="4153241at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651052" evidence="2">
        <location>
            <begin position="27"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="225" mass="24091" checksum="1B52FE4435E776C7" modified="2016-11-02" version="1">MTVTMATLSQQVLVQLLTTTTTTTTATTTRTPSTSVPRRYMKTHQQYLGHFSFLPSDPSRHGLTRTFSGQVTTTVHGVETILPTRDYLKHIPEDRHTIIHPPGLVMESGYHNAKAMGPPLNAPPPPPPIDIKTGRPLSVASGTASDVGSIHIPPPPPPPPPPPASVHSAYHLPPPPPPPPPPPASSHVSSNSDVEQCGKCRHCYGVSLYELKLPLLASYDCAQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVA4</accession>
    <name>A0A1C1CVA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_10220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVA4"/>
    <dbReference type="STRING" id="86049.A0A1C1CVA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10220"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03835"/>
    <dbReference type="eggNOG" id="ENOG502RSJA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="23"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT52436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="331" mass="36812" checksum="C2A293D0FAEF1335" modified="2016-11-02" version="1">MATDFNTEAFTLLAVGVLVVATRTASRLSIAGIKGLWLDDYLMLFATVVYGLETGTAYAVGAWWHGLANNGMTDEERRTLDPNSQEYQFRVNGSKTQLVGWSLYTLLLWVLKLCMIIFYQRLTETLDHMKMRVRIGYAVVISTYLATELSILFGCHPFHKNWQIYPNPGNHCQPAISKIDLYVTVVLNVFSDAYLLSIPIPMLLKADVPMVKKLSLIFIFSGAIFVMAAGILRAALILEDPVGGAQAAGSWAVRETFVAVVVCNLPLVYQGGRLLFKSPAAKNLFSRATSRQGYSKSSDDSNFEMTSKSTVPETDFDARRTQSQQEFFKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWA0</accession>
    <name>A0A1C1CWA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10613"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04166"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="238" mass="26869" checksum="8E6BA63687733BDA" modified="2016-11-02" version="1">MADTQPCILYYDPRSICSSMNFGPIDIVKGDQLSELYLCEINPKGQVPVLLSPGFLDRPITDSLDITLWLCERYPDLRPLEHAEEINSLLRNLHVINFFSLSMRNRPQRASTQEQAIHAQLNVPGLSDRHKKALEYKLEVTRAEKVGGVKPEVIQAEIERTRALLTEIDNTRKANNTTNSEDAWIFGTAAPTALDTTLVCLVARLMDVDLAELVPTALLQLTQKKRNTPQFKDIWTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWF2</accession>
    <name>A0A1C1CWF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Chromodomain-helicase-DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_09434</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWF2"/>
    <dbReference type="STRING" id="86049.A0A1C1CWF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09434"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04209"/>
    <dbReference type="eggNOG" id="KOG0383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056616">
        <property type="entry name" value="Chromo_MIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041684">
        <property type="entry name" value="Znf-PHD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23615">
        <property type="entry name" value="Chromo_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15446">
        <property type="entry name" value="zf-PHD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="841"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1161"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="270"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1418"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="393"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1432"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1468"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1489"/>
            <end position="1505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT52869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1505" mass="172284" checksum="6607E31CC76CFD19" modified="2016-11-02" version="1">MSGTDLSEWVGKPPENSRKPGGPEVSAEDSIEAVVQRPVNGEDIEVKEFEDDTSFAPDEQAGPSHSDESDGGDILHDHEITNTKPHRGRVRSSDTSPSDQDATEVDYDEERPLVGLFQKRFYIDVPRLADEVKETYDYLPGHFVVERVLSQRKDKRYIVRLESGERDITGTCPLILSHICDCSFSASFTVLPAFLFQSPHLSFHPFLGATCSLVTINESLTLPAAQLSARRIHELHNGYDALRAFEDSQPQARRPFQRNPAMVDWNTVSLTDSEGESPPGPRRKSPDDSDAEPGESEEISERDEEDGALDEDARNGRRSARLSKLRKTARLKQELDDLQGETRGRLRRSARGTRGRSTLRPQRESTRGSIRPQRRSRMRDESSPEADVAMPARRSERTRTQPKRSMRERQEDEISSYEDEKSAPKVISTKEHFVKVPDHDPFRRRHRQECETCYFRGDDQAKGPLVFCQGCTNSYHKKCLGFRGTRDHLVTKVGEQLFVLQCRRCIGLAQDKERTAPHQGRCTSCREYGELSKPLRGRLTTRQEQLQREENGGTDPITIVESRLINNPSLVMFRCSQCARAWHMHHLPRRQTAHSLDDEDESTLDEAHLAQKRFEHYHRSWVCKDCIENQHQIDALVAWRPVNLDSYHPGTVVTELPEDEKEYLVKWRTQSYFRTTWMPGGWVWGIAPGNMRMSFLKKPENQLPKIATTDAIPEEVFRVDIVFAVRYSSVVRNSTKEIDLARAKEVDSAFVKYKGLGYEDAIWEKPPPPTDIDRWNDFKAAYEDYVMKLHIAIPPQSTLRRHLTHIRTLDFEKSVMKKNQPTSMVGGELMRYQLDGLNWLLCKWHLNQNAILADEMGLGKTIQLVSFFATLVQDHKCWPFLVVVPNSTCPNWRREIKKWAPSLRVVTYYGSARARKLTHDYELFPKDKEEDPNTPPKRKDREVKDIKAHIVVASYESIVEEKTRMSLMKVPWQALVVDEGQRLKSDRTQIYEILSKFRFPFKVLLTGTPLQNSARELFNLLQFLDKSMNAAELEAKYANLTQENVPELHDMLRKFFLRRTKAQVLTFLPPMAQIIVPVTMSTLQKKVYKSILAKNPELMKSILARDGTANQKEKHNLNNILMQLRKCLCHPFVYSRDIEERGAEGAASFRNLVDASSKLQLLTIMLPKLQERGHRVLIFSQFLDNLDIVEDFLDGLGMQHRRIDGTISAAEKQKRIDEFNAPDSQYFAFLLSTRAGGVGINLATADTVIILDPDFNPHQDIQALSRAHRIGQKHKVLVFQLMTRESVEEKIMQIGRKKMALDHVLIEQMDKEEDAGGNLETILRHGAQALFEDDPGVQDIVYDDVSVDRLLDRSQIEDTKIDTEKSAESQFSFARIWANDKSALQEDLPDRTANNTPNPGIWDKILQERERVFAEEQARKAQAFGRGKRKRQTVDYRLGDRDGEKAEPEPAEADVAPGDPDYRAREQSDDDGATETDGATESDLEPMAKRKVQGRKFKSSPRKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWF8</accession>
    <name>A0A1C1CWF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleolar protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_09706</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWF8"/>
    <dbReference type="STRING" id="86049.A0A1C1CWF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09706"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04134"/>
    <dbReference type="eggNOG" id="KOG1122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="13">
        <location>
            <begin position="294"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="612"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="678"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="386"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT52785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="724" mass="79221" checksum="6E25FF41A0EC52E4" modified="2016-11-02" version="1">MGVGRRMRKQGPPASLEELGIKLKRKAGADEPKQPARKRRKSDEKQKGNAPKKLVNLDRTLRDESAIVAKKAKGKKKIVNNDAQITVPPPFPIASEPVDGEYGDEEDEGQESEAGVAGVPLNDASLSELDDEDDELDEADLDGELSDDSVFDSDPDEAPRRMFSDDEDESDAEAKLTAANIEGLSRKLDQQQAQVDAEAQEELEDAIQTNIATDEGVLDSVTAQGLAPDLGMIRTRMIETIRILGNFSQLADKNKSRTDYTEQLLSDICTYYGYTRYLAEKLFNLFTPAEAFAFFEANETPRPVVLRTNTLRTNRRTLAQALINRGVVLEPVGKWSKVGLQVFEAPVPLGATPEYLAGHYILQAASSFLPVMALAPQPNERILDMAAAPGGKTTYISALMRNTGAVFANDANRQRAKGLIGNIHRLGCKNTIICNYDAQKAFPKILGGFDRVLLDAPCSGTGVIGKDPSVKTSKNERDFLALPHMQKQLLLAAIDSTDHTSKTGGYIVYSTCSVTVEENEGVVQYVLRKRPNVKIVDTGLGTFGSEGFKSYMNKKFDDKMVLTRRYFPHKENVDGFFVCKLKKTGPTPKSTGQSAGRTDAEQETAVLNGDAKSILNGVGGNDEEQPTPGDDFGGFDDEEDKEHIERAEKKWLKSRGIDPRVADRKKAEQGQGNKKRGKSGDASRTEDVTGKVNHHGEKQNGAKVNGVSEKQNSKKVKAKGRGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWI0</accession>
    <name>A0A1C1CWI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal specific transcription factor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_11397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWI0"/>
    <dbReference type="STRING" id="86049.A0A1C1CWI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11397"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04136"/>
    <dbReference type="eggNOG" id="ENOG502QURZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="610"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="749" mass="83078" checksum="9948BAC94B680F43" modified="2016-11-02" version="1">MPRPRVKDEDRKRVARACDTCKRRKEKCDGQQPCLLCKRRGREPECVFSDVFSKGGSQRQTSTPSSQPITLKDALNESNDAEIAIESLLTLSGSRSAAKTPQYDRDLDDVISKAPVPKLARLLRDGRGKFIFVGDSSNLAFVQNIRRLVKAEIGECPLTSDPLRHAMCEVIPPHKVPTPAQSQHPKPTVAEAQDLIKHYLLASSGVIDLFDPDDISDHLLSWARDSTAETDFNSSIYYLVMAIGALTRTSSDLDQAEFYFLRGREIGVSSFLEDPSVLTIQAYTLITFYMLSAVRRNGAFMLLGIAVRAAYALGLHRSDISNLFEPRERAARERVWKSLRVLDLYMSGSLGRPPATSEVDGGSVSWNRSSRDYEDIQMNGRTTSATLRICFIFERILNEVYCRREVSVQLVESISRQYRDWTMQLPAGLQADSLDSKEGSTAPSLRQTIGIAHLKGAYYWSIILLTRPFLIFKVSSKIKGRSEDEDSAGNSVTMTLSEACIDAALRGIEIATDIVHTIGVPKRLFMITNSTFISAMVIGFAIFGDFDKSFPLLSSMAQAEAILTIMAKDDLSARRQYEITSYLRLAALEHINRRDQIQMQRRRQDIHNIFGDPINKANGSTPTRPSTGSHTPDQILTSDVAQNGKVGNALFDMADAGDAAPPWQLRFDMPPESRGPVLTTSGALAYAGEDSAEQIPPLPRTDFGQVPDAGYLSPNGSGIPSLPSYAEEFPLFSLMTEFDQLQDPFMVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWI8</accession>
    <name>A0A1C1CWI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="11">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">icdA</name>
        <name evidence="17" type="ORF">CLCR_10183</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWI8"/>
    <dbReference type="STRING" id="86049.A0A1C1CWI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10183"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04254"/>
    <dbReference type="eggNOG" id="KOG1526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="36"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="125"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="341"/>
            <end position="346"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT52913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="451" mass="50733" checksum="FA0ABBDB1162248E" modified="2016-11-02" version="1">MAPTASTRLAAEQRRIGGARTMASSTSATKIKVKNPVVELDGDEMTRIIWQDIKDKFIHPYLDIDLKYYDLGLPYRDQTDDQVTVDAAEAIKKYSVGVKCATITPDEARVKEFNLKKNRRKVWLSPNGTIRNILGGTVFREPIVIPRIPRLVPGWEQPIIIGRHAFGDQYRAKDTVIREAGTLEMVFTPQNGGSPQKIKVFDFAESGGVAQTQYNTEDSIRGFAHASFKFALDRGYPLYMSTKNTILKAYDGRFKDIFEEIYQSDYAKEFEAKKIWYEHRLIDDMVAQMIKSTGGFVIAMKNYDGDVQSDIVAQGFGSLGLMTSQLITPDGLTYESEAAHGTVTRHYREHQKGRETSTNPIASIFAWTRGLVKRGQLDETPELVTWAESLEKAVVQTVNDDGIMTKDLALACGRKDREAWVTTSQFMEAIEKRFKKNLEGEGLEGVAKAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXU8</accession>
    <name>A0A1C1CXU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11107"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="78" mass="9139" checksum="D552D02B5603CDC3" modified="2016-11-02" version="1">MRRNTMQVLQVSSDLKDRPQHKAPMYQRSDQVVQVILHNTQRGGQGREPNRDDEVRDKRLNQDTIFVIPAVWKPLCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY65</accession>
    <name>A0A1C1CY65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_09936</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY65"/>
    <dbReference type="STRING" id="86049.A0A1C1CY65"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09936"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00327"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF8">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="554"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT53360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="589" mass="65911" checksum="0830861F6C738EC3" modified="2016-11-02" version="1">MIPSQNMLPTPPSSQPSTPTHSRVADLGLDGEPLSSQSRSRRASSSPSSRLRGQDLFDSRVFQNAESTTVFYQFIASMRHKIRDEVRSTSSVHKFIRVLRDGGRLMRCYTQNIDGLEAREGLVTDLRRGKGNKRRFMKKHYEAPRPAQTLSSDFDGGCEVVQLHGDLDKLRCTMCSTQYEWRDEETDIYLEGAAPSCPKCKEKSEDRQATGKRGLAVGSLRPNIVLYGEDHPSNTLLTPLIPFDAGCRPEVLVIMGTSLKVFGLQKIVREFAKAVHSHKNDKGRVIFINRTRPAESVWEGIIDDFVAMDCDDWVDDLKKRRHDLWLRQGEIDMTVTKSAQPKRKRKSIEDEGAKENKPCKKAKIVVEVPSHHAADGGSPSDILSRRLVTPKKIKLPRDYPGRAILSPLAQARRPPVSPFTSPIRGDEESALPSPRKRGTPLRPPISPFSSPVRADPDKEPSILKKWGTPKRPAFSPFTPGLWTGSKLKMEVCRDENEFCPPSPSIVDPEAEPELDEDTVVVTETQQPGKVDGSKALPFMAQVWQRVRESCVFSYGQEPNSSQQSMEDDVGEVDTPTRGPRGRRIDVLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYE8</accession>
    <name>A0A1C1CYE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative metabolite transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_10109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYE8"/>
    <dbReference type="STRING" id="86049.A0A1C1CYE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10109"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00491"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="41"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT53525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="501" mass="55316" checksum="EC13B2FF83F0FD9E" modified="2016-11-02" version="1">MDTADEKIIKENVGSEAARRYSIHEAALDATPKSRWERTWPVLACGAGLFSDGYLNGVIGSVNTMLKIIYKDEYVKSDAQNNVSSIAFAGTVVGQLVFGYLSDHWSRRHSLLISTIILIIFSALGAGSYGAGGSIQGLFAALTAFRFLLGIGIGGEYPAGSVAAAESTGELKRGHRNRWFICFTNLAIDVGFVVAAFVPMICALIFTDKHLRAAWRVCLGLGVIPPLSLLYLRIKLQEPEEYNRNKMNHYPYWLILKFYWWRLAVVALIWFIYDFSTYSFGIYSSSWLAFLLPSDAPLWKSFGWNTVINLFYVPGAVIGAFLSDWIGPKYCLITGVLLQGIVGFIMTAIYKHLDQASQVGGFVVIYGIFLALGEIGPGDNIGLVASKTSATSVRGMYYGIAAACGKVGAFVGNYIFPDIIKAAGDDVIKQGQYPFYVSSSLCIFSGIIAFLFLPNIGQDTITEEDERFRQYLIKHGYDVNTLGTRKYHEERTLAVEKAQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYI6</accession>
    <name>A0A1C1CYI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alpha-glucosides permease MPH3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MPH3</name>
        <name evidence="10" type="ORF">CLCR_09819</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09819"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00556"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF53">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="55"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT53599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="559" mass="62110" checksum="6C030BE0E2C5A718" modified="2016-11-02" version="1">METEKVVPAAFERHILDATHNETLELVRHAQESDAADRQLTIRQALSKYKKAVFWAMLLSTSLVMEGYDLVIITSFYGQTQFRTRFGIQDPTTGKHVIPARWQSGLSNSALVGQLAGLLINAYTQDKFGCRPTMMVFMVWMAVVLFIPVFAPSLSVLAFGEAMCGIPWGVFQTLSTTYACEVVPTILRPYVTAYVCMCWGAGILLSSGVVRAVAGIEGNLGWRLPFALQFVWPVPLFIGAYFAPESPWNAVRRGKFELARTSLQRLRQETPDKEREVDASLAYIKYTTELERAETEGASFLELFRGTNLRRTEINCVVWAAQILCGNAILGYSVVFLEAAGFSELQAFDVNISLSACYIIGGIICWSMFPHFGRATIYMGGLTLMFFCLVAIGGLGWSSSKHAQLAIGILLVVSTLINMITVGPACYPIVAETPSGRLRYKTIVIGRFVYNLTGIFNNSVTPRMIAADSWNWGAKTGLFYAGTNLLCNIWCWFRLPETKDRSFGEIDLMFENHVAARKFKHTKVDRMPEFAIGQATQKEIEASEKHASAELRDVAAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYL8</accession>
    <name>A0A1C1CYL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione-dependent formaldehyde-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_10871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYL8"/>
    <dbReference type="STRING" id="86049.A0A1C1CYL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10871"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00551"/>
    <dbReference type="eggNOG" id="ENOG502SV9S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406544at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF33">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT53595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="152" mass="16975" checksum="40E1EFBB38933C34" modified="2016-11-02" version="1">MAPQGVVFPIEGGCRWCQRETGASFALHAMIETERLKLLKGEPEWTTVPSASGAGQRIGRCATCKTAVWSVYNAGEIKARVKDSIRIVDVGTLDNPDAWPPDAHVWISDKQPWIILSNKTPAFQDSNYVREEVWSKESLERRRKAGAFSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYR1</accession>
    <name>A0A1C1CYR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYR1"/>
    <dbReference type="STRING" id="86049.A0A1C1CYR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10392"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00624"/>
    <dbReference type="eggNOG" id="KOG0805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF2">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="376" mass="41394" checksum="E4153CE2081E314C" modified="2016-11-02" version="1">MALPTLRAATCHVSPHVLSAARTTQKTITCIKTAARHSANLVVFPESAIPGFPVWSSLLPPTQAHHFFQRMVQESVYVDGDEISQVRQAARNARVTVSLGISEKVRYSSATLFNTNLIIGEDGEILVHHRKLMPTFYEKLTWSPGDGHGLRVADTKYGKIGALICGENTNPLARYSLMAQGEQVHISSWPAIWPTRPLDNAADAAWTKRESRNYDNIAANRTRAAAHCFEAKCFGIMSAGHIDEAAMGEIAAMTDAPEAMLRKLASYPRAASQFLDPTGRTVDDCLAVDVATDRQLDGQSVVTDKEAILFADLDLNECIEGKQYHDVVGGYQRFDVFTLQVNRQRHEPVQFQDASLRDPGKVNEQSSGGNESTRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYW4</accession>
    <name>A0A1C1CYW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10185"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="187" mass="21100" checksum="8056DA30F70C43A7" modified="2016-11-02" version="1">MQWTGGEVLIMVEGARSISRNTSSLAASSCPLLGLFHMQTSKNEETGDFERLGDELAVRVTRTADDRHEVSSHEPPTTATRSERSITATDDRHEPRMTATRSHHDEPPMTPSLRVETRETAIGLHNAVCPCGGVVRTTFRFRLVWWERKSSDMKFETERSTAESAANQRQSQQKLNSTWESPSEDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYX6</accession>
    <name>A0A1C1CYX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Yipf1</name>
        <name evidence="8" type="ORF">CLCR_10467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYX6"/>
    <dbReference type="STRING" id="86049.A0A1C1CYX6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10467"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00641"/>
    <dbReference type="eggNOG" id="KOG3114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="112"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="292" mass="31990" checksum="3B3D08B3AC690555" modified="2016-11-02" version="1">MANRGYDVVVDVDTEGDLGHTDLQDDDLEFHSSNFESNPSSQRKIQPDTPFLSTGSGANNLGAVPSSSSTSAPKHMLWSLSFYAQFFDVDTTTVLHRCRSAILPFIPNTPPFLDIMDGNPDLYGPFWIATTVVVILFLTGTISHKLATEGKKHFEYDFSLLGGAAGLVYGYTLFVPLGLWAALRWFGAQSLELVECWALYGYGNLFWIAVALASWSPLNGLNYALVGLGYAVSVFFLVKNLYPVISATEKKISQVLLVAVVLLHAGFAIAIKVLFFSHMSPAKDDDSKARLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ74</accession>
    <name>A0A1C1CZ74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Erythromycin esterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ74"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ74"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09698"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00668"/>
    <dbReference type="eggNOG" id="ENOG502T00Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5204833at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="79108" checksum="2DD76915DE86D5C9" modified="2016-11-02" version="1">MSQLSRLSGLKTPKTEPRPDRGEMHPQLLHQTTAKEPDSGLKLGFVDPPPQPPHSIASAQNTPSRTRSSNAKLSSTTFDFNFGSESALSNEAQKMMDSVREEAARIKAQMQAEREAQKQKDSDAEAVFGGINAAGRKIAKPKGKASRFSDIHMAQFKKMDSIANHPSAFRSKRPGFAQPTTQSLKRSGSKAGLDEVDRPRTAGKGTPGRKPPPFLGRPTSVSPFKSVPQQPERTEKPAQVKRARHSEFHDVSASRASEHSQTARPVNHPSAVSSHLLSPTKASLARAANSQIPVASPKKTPGLTRTTSMKSLRATPAVPNARPSTSHGVGSNEASTKIPQFQLSLERPLPPLPNETCSSPQLALEQPSKSVPCLPAPSNTSSFASRLPKLSGLKSILRSPRKNESPALTKEASATPKRPTTATATSATGSIKKVDFTPSVKSRYAVKLAAGSPSPAKLPQQLTPGHALAPVIPYDPAAYTIDDEDGWEDAEDASSEIEYPMLPGTSSSPGSPVKADNSFINKAKEHNRRESKEFKSIFTTLHHPSRTSAPSTLTSVNTTVNKNHAPANANKVMRSPGNINFSNPSPSTIRRVRTSGVTSVIQPFEDTDVKTMPHGLPGKKRRRASEDQQDTDGESGKENRRASIMPSVPGGWCDSTHNDDEEQDEGEKRGGKRMRTAPSPEKMSVVAADTTSPVKKPRQSSARELAKQTAKERKGGRLMSLSRLNFLSQPKQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ89</accession>
    <name>A0A1C1CZ89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ89"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ89"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10075"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00782"/>
    <dbReference type="eggNOG" id="ENOG502QUH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2127032at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000030">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000778">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF6">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="83"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="420" mass="46228" checksum="2F1055677ACAFCF8" modified="2016-11-02" version="1">MAPPAVLMVGTGEYTTGFVSGAASTSDKKVGVVGLTLFDLRRRGKVSDLSMVGVSGNKFPSIRAHLKKNICEAYNGLDVSFQSFPADDQTDPEAYKAAIDALPKGSAVTVFTPDSTHYPIARYAIERGHHVLVTKPATKLLAHHLELLALADAHGVLVYVEHHKRFDPAYADARFRARALGDFNYFYSYMSQPKSQLETFKAWAGRDSDISYYLNSHHVDICEWLVRDAGWRPTTVRASASVGIAEAVGCVKGTEDTITLLVDWTRTADNKRATGIYTASWTAPMNAGVHSQQHFHYVASGGEINVNQAKRGYDVVDEADRSGSSLKWYNPFYMRYAPDEEGNFNGQSGYGYVSFEKFIDGVTAVNDGRLTVEQLDKRGLPTLRNTILTTAILEAGRRSLDEGNRLVEIVVGEGDRVELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZD1</accession>
    <name>A0A1C1CZD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arb2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZD1"/>
    <dbReference type="STRING" id="86049.A0A1C1CZD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10191"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00770"/>
    <dbReference type="eggNOG" id="ENOG502SGUN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arb2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="385" mass="43628" checksum="DFCAF51B86BB7D07" modified="2016-11-02" version="1">MFRRKADTLPADPIFEPNLEKLGFFINDEDQVRSVRNPERKYQYQINRNERWNQVHKGANNAAVCNIVQERLLDLGFERVRLPLGAAEQENHVPILVSKDIASKDRVIIIFGERNAEPGILSWRVIGEEGIRHGSLVEFATAVLSTRAPVSTVVSTATKTGATNENITISTVTTPGVIIANPCQLLWYRGGSRAVSNYEWLCLPRPSAVHDAPRVDPVKNRIPGNHDYVEHVQYMFEKVIPSLVNERARIDIIGVEFTGTAVVEHLAEHWNVWSPRITGIALVTPQHKLADLKAQGAPSAFIEFLSKRCRAYFISQSDIEKPVVGREQFGCNCYASGERHVEESALVRSWRHILDWFDMLHVNPGYEEVEYEVVDKNEEIKLGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZH0</accession>
    <name>A0A1C1CZH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_09754</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZH0"/>
    <dbReference type="STRING" id="86049.A0A1C1CZH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09754"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00846"/>
    <dbReference type="eggNOG" id="ENOG502QVHD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="642"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT53933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="675" mass="76536" checksum="B9B611F204256AF7" modified="2016-11-02" version="1">MDDEKRDSRGGSTEVNDEARPHKRQRNFIARQACEACRLKKTRCDEDVPCSLCRSLGIECTYAERKPTKYRLMSNIRNEVSMSMVFSALRRMELKLDGLSSTVSARPGPEPEVNRRESSLQESPPYHLDSVASHHSLSSPLSSTRQIHRHSNGQVVLSFSAHQTIHWPGVQALLPQNLASTARSLEKSYPTQLESGRLSLTPTVSAQAVALTGDWLASLSLTCVKDLSNAYFDTFNRVYPFVDRDHYFSNTLSVVVREGFGFDIESCLVLNIMALGCMGLKSFEEGGFAAHHTAITPLIRHIMDEEMSGLSFFNEARRRVGLCLCERTIEACQYYLTSASYFAQLMRPVDKWMMTNRAAVICTAFWKCPSEPHDEWVADMQARLFWCSLTLESLVVQELELPPSGLKSFEDEVPLPKFTTYPYISNSRGHQADDSIYHYHFLAQIAQRIILNRIRDELFFSNPSTKLAEELRHQLEQWRSNLPEALRYSGEQDFPCPADAVVVALLQMRYRVSIFHLGRPFLYKAIHNPAAVSDGELKLCAEALEYAMDWHMTLPVCSSMKNFAPLKYFCCGQFFGQLLIFHAFKTSSERRLRDTLPAGYESWCNKMLRFIYDFADPESSPTIAKDFELLSTLYHVAENQGNGIIPRPRRPQEAVSAKLGSSRVDRTAGSKGART</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZM4</accession>
    <name>A0A1C1CZM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">syf2</name>
        <name evidence="11" type="ORF">CLCR_10512</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZM4"/>
    <dbReference type="STRING" id="86049.A0A1C1CZM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10512"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00882"/>
    <dbReference type="eggNOG" id="KOG2609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT53975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="331" mass="36928" checksum="BF1D7C6D3DC14C0B" modified="2016-11-02" version="1">MPPAKRRKLTPEPEEQPATAANTETPHATANPTEKDAPQAISSAIEAQDPALVAESTSNPPGAASNGAPEPTTSTPTPAADRLARFAALKSRASQSAKSNLAEAKAEATRAAMDPSLLANLSRRSAIAQHNLLKADTEETEGTGAFERKRAWDYTIEESEKWDERIAAKKHARENNAFQDYSVEAGKMYDRQIRELEKQALKDGGKNREDYDRQKAEIIENAARTGGLEIVEMDNGELVAIDKDGRFYSSQDSLGFIEQKPKRENVDRLVADLRKAEEARFKKRRDRGREADDGDVTYINDKNKQFNLKLARFYDRYTRDIRESFERGTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D062</accession>
    <name>A0A1C1D062_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D062"/>
    <dbReference type="STRING" id="86049.A0A1C1D062"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00165"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02547"/>
    <dbReference type="eggNOG" id="ENOG502S9SC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018853">
        <property type="entry name" value="DUF2457"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10446">
        <property type="entry name" value="DUF2457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="736" mass="80595" checksum="D63B2CC3CE88A4FA" modified="2016-11-02" version="1">MSNTPTVPLDDDELGAEPDEPPDDQVSPLTSVAPHVTLYNRSMAPGYSRRESLLTRAIMAESKHEDDIHGFPSRGLSTTSSHSTASMPSTAELTSDGDTSQSRSATPSPPPPSSRFSQILNLRKASPRVVIAPVTKHEKETVAVAGEAAVEKTLGRKRCIMFACGGTESEKSKENLSKEGSGEPEVPKRKCALTFACPTQSTSKAAKNAPSTLQVDVKAARRPSPAPATRRKSTSESVDLSGRSAETARITTSEKANLSPTPKTAFHEFGTSQDETDSWVDKPSFHREKLTLDDCMRKENRIRQIGQEAEEEAEEEEREQDDLEADVEVNDHEDDFAPSEDGSDGGNESDDEGGFASSDEESDAGSEYQFWAPFTANTASSTENLNITHFSSRRRSEASSVESMTHSSNSHLRSMMLQAGRRRNNASKVPKMRPGTPELPDSTDFVCGTLDEDRPLEAAYLSCREQRMRQKHVPIPQDIDPSFPTTDPEDNGNESDDEIGGSQHSSDGPRWLKEDFAGFEDDHYGRRKSSIVSPVDETPSPPHVVTGVRPGRPNVRSPLPRVITARSPPPRKLFGHSPTRNRSPFPLAKLRSPRGSPTTTGVPTKLRLRGLAQRPGMERTASLPDTPNPFFKNFNIGSPSISNIASGAVTPAVEEPPRADMHVRGPVDIVAGLENKRQKRKEKFWRQHCRKAAKEQAERKPVPGRGAERMKELGLECAERTRGYGIGQQTQLVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0J9</accession>
    <name>A0A1C1D0J9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit 12, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cytochrome c oxidase polypeptide VIb</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cox12</name>
        <name evidence="8" type="ORF">CLCR_11434</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0J9"/>
    <dbReference type="STRING" id="86049.A0A1C1D0J9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11434"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09456"/>
    <dbReference type="eggNOG" id="KOG3057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1107506at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281:SF8">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 12, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="95" mass="11104" checksum="57D4E309BBD796ED" modified="2016-11-02" version="1">MPDIEVPDAEELGGNVTKPFKFVTAGYDARFPNMNQTKHCWQNYVDYHKCILAKGEDFKPCRQFYLAYRSLCPSSWVARWDDQREAGNFPVDLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0S2</accession>
    <name>A0A1C1D0S2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0S2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00923"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01706"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="232" mass="26918" checksum="D0B862EC9EB4EB46" modified="2016-11-02" version="1">MPQPYLLWVNSRPKPESGVDDDLWVKWYTEEHVPDLVNTKTAVRAAMYRETFDFPLAAKEHHPRKYLVLYQTDLEEPLKSKEYLDGVRHSSGLWTANKPTSEVGDFHARNYKLIQDYDPDGRGEVAPRFCLTVEMDPVDEADFHKWYQDEHLDMLHKLPGYRRSSRYVIGPKTALMDGEPPKYLAIHELDGLAGMDSKELHAANDTPWTVKHVNDSKVFIARAWELLYSQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0V6</accession>
    <name>A0A1C1D0V6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2 zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_00801</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0V6"/>
    <dbReference type="STRING" id="86049.A0A1C1D0V6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00801"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01743"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001666">
        <property type="entry name" value="MDS1 and EVI1 complex locus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="244"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="371"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="650"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="474"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="610"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT54483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="685" mass="72128" checksum="A8034CA37C972C9A" modified="2016-11-02" version="1">MRHSQPWPLSWPRAPSTRIGDATFVFVGLQLTPQAGHKSPKLHQKLLMAEFSPDPQISPGDSSPASPTFVKPTSSVQDSSKARVSSRDDFEESSRPGKRPRLESPLMTAAAALAEGQQKSFRTTPPPSTGTSPNPTQQALSALMGASSNITSKAELHSDAPFDPVTTISEPLAVVAENVQQPSAGAGESSGTGENHALTSPTSISSIGTVGSLEGVAGVSGMTTTVGSPLPIEETVRQVVNAAEAGSTSPTDVAKTGALSYPTPFLQPTHPEGGRRGMSLPHSGTRQGTKSPSSKKHRCPYCATEFTRHHNLKSHLLTHSQEKPYVCSTCSSRFRRLHDLKRHTKLHTGERPHICPKCGRKFARGDALARHNKGPGGCAGRRASMGSFGGDEEGEADESMEGIMYDEPPNMDDEEGNERRPTPSIRRQAPSGDDSVDESEPAARIPSTYPPIQGRPPGGIAAGYFAPRPGYSQSSAGPSNAPVAASVAPGTFTSVTGSSTSSRPSAAGSVFAQNPMTESPKPLSPGQAQRPGATANDGRNRSPSTTFYPQPHPRSTGSGSSLNVPPGAPQLPPPHAPHGLNPPDPRYTLPSQGGPAHPPTQPSGPPTHMSGSGPLSSHSNSLSSHGHSGHGSGETSNPMFAQSDRIWAYVTTLEQRINNMQEEINSLQHQLANATQHQQQQQQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D168</accession>
    <name>A0A1C1D168_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_00798</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D168"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00798"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01755"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF18">
        <property type="entry name" value="NICOTINIC ACID TRANSPORTER TNA1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="53"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="508" mass="55935" checksum="DFE2984335F7B919" modified="2016-11-02" version="1">MAEERGEKTSVGEKDVVYDHAKSKHHDPNWTGEGVDTSTVDAKKVLRKMDLRLIPMLAILYLLSFLDRGNIGNAKIQGMQTDLDLSGPEYNLCATVFFFTYCAFEIPSNLLLKRFRPSVWLPAIMVAWGTVMTLMGLVQNYHGLLIARIFLGVTEAGLYPGVAYYLTMWYCTEELAFRQSLFFSAASVAGAFSGLLAYAIAKMDGVAGQEGWRWIFILEGLLTVAVAFAAFFLLYDFPDTASFLTTEEKAWVVHRLKYQGSKKSGRIVAESDHFEWKFVRKALTDWQLYLSLLMYWGIVCPLYGISLFLPTIIKELGYTSTTAQLLTIPIYITAAILAVVVGYLSDRATKRGASRWPYIFVPMCAILVGFIVAISGSAAGDIPGVVYAGVFIATCGIYPAFPGNVTWIANNLAGSYKRSAGMALQIGLGNLGGAMASNFYRSVDAPKYLLGHGLEIMFVVLGLGAVITLRISYGVINKKREQSGAAESYSDEQLADMGDKSPSFRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1C7</accession>
    <name>A0A1C1D1C7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1C7"/>
    <dbReference type="STRING" id="86049.A0A1C1D1C7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00874"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10114"/>
    <dbReference type="eggNOG" id="ENOG502S1BG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="94"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="409" mass="44685" checksum="8F274CF0980DF418" modified="2016-11-02" version="1">MAPASSLNPISMHWPILVTASALFSIGVLAGGLWNKKRASTMRSPRTTLLPKLSKEEISDLPYPPDVLPGGRDVDTPYGSIRVYEFGPEDGRKVLLIHGISTPAIALGGVAHGLADNGCRVMLFDLFGRGYSDTPGDLAHDIRLFTTQLLLVLASSPLSWTGHNRSAKFSLVGYSLGGGIATTFASYFPDLIDSLILFAPAGILRPYHISKTSHIIYSEGIIPEGLLERVVRRRLRSPMARPLRTTTTTTTLSPNEDAGKTVVGATEAAAAEVGKGVNLESNSRAVLSKTRPHVTVEKAVLYQLDNYPGFVHAFMSSIRYGPVRYQHDRWRIFGQHLARQNQVHGTNKKVLIVLGRNDPIIIQKEVEEDANDVLGGNVEFVSFDAGHEVPVTKAEQVVRTIVDFWSRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1I8</accession>
    <name>A0A1C1D1I8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1I8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03199"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="73" mass="8390" checksum="6BE3FE8064F19246" modified="2016-11-02" version="1">MYLERACGTYLYLITHVGVLSVADLLVCQFSQFGFAVVTVHSFFTHRRVRISAQGPSQRLWPPRFNVESIRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1T3</accession>
    <name>A0A1C1D1T3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NHX1</name>
        <name evidence="13" type="ORF">CLCR_02782</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1T3"/>
    <dbReference type="STRING" id="86049.A0A1C1D1T3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02782"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04760"/>
    <dbReference type="eggNOG" id="KOG1965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="48"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="485"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT54654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="690" mass="75288" checksum="052F76D272F9F743" modified="2016-11-02" version="1">MASSLVGATLNLLRRQVEDADPDEPSEAGQKEIFSSWALFILIMLLIAALFMSYILQQKKIQAVHETVISIFAGMVVGLVIRVTPGTVIQDTVSFDYQFFFNLLLPPIILASGYELHQANFFRNIGTILTFAFAGTFISAVSLGLILWLWTRIPFDGLQITWVEAISVGATLSATDPVTILAIFNLYKVEPKLYTVIFGESILNDAIAIVLFETAQRYREGGAAGNLNIISLFEAIGIFLLVFFTSLVIGVVVGIGTALALKYTFVRRFPRIESSLIVLIAYASYFFSNGVHMSGIVSLLFCGITLKHYAYYNMSRRTQLTTKFVFQITAQLSENFIFIYLGLTLFTETDLVFKPLFILVTVVGICGARWLAVFPLSKAINYIIRVRAKRRGRDVAEELPWHYQVMLFWAGLRGAVGVALAAGLQGNEGPALRATVLVVVVLTVIIFGGTTARMLEILNIRTGVVEEIDSDDEFDIETANGGTYYKRSGTGFGHNPRSSSIGLDYVGHAREGRPNGSASRPRPDRGYSSSNGRSPPVRGGNQRKNSTISQREREIAAQQGKLLYGNGSMSGSTSDDEEDAVDLDLPPAAPRRKQSPLAGGPDARTRSAPDIVLNNGDDDPLGVDHGDMGTVAQTEGTSTPLAGATSSIRNLLRGATGDHTAWFRQLDEDFIKPHLLLDQHQGQGKGPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1V9</accession>
    <name>A0A1C1D1V9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1V9"/>
    <dbReference type="STRING" id="86049.A0A1C1D1V9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02802"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04863"/>
    <dbReference type="eggNOG" id="ENOG502STDD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4161523at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="641" mass="64494" checksum="09D8E5985AFB2F58" modified="2016-11-02" version="1">MASTTSDTTSSLTSVDSTSSATTLVTSTTSDTSSTTTTSSSAPPTSSTTSDPPSSSSTTTSSSTISSTTTTTSSSTTSSSSSTPPPTSSDSSTSSASTTTSESGTTTSSISPSTLTTISTIPSDLPSSTTTTLSTSSSLSTSTHSSPSSTATPSPSPTTSSSSPPPPTSSSTTTPPPPTSSTTTSSTTLSTSTTTTSSPPPPPSSSTTTTSSPPPPPVTTSSTTTTSSPPPPPPTTSSSTTSSEPPPTSSESSTSSATPVVITTSTSSIVYETSTAFVTQTLPVTSSDGVAGYTTITSVVITTEAATTIVEPATFTSTPGAPTLVAASSDSSSSSGLSTGAKAGIGAGVGVLVLAAAIFGGWYSWFMRRRRKRQSYSASDRYSDNPLGPEMTGLGIGGGAAAGMGAMAAVSGYRDTSNRSDRLTDVTRSDLPSPPLPSPPPRSPDRLLPPTAATIRSWGSTSPPPQGYPGPSNMSVSDQSEYSQGNNQYASHFGNQHPQQQPPAGVAAAAGGYFPPPNELPDNSRNIHQLPDDVPPHPNDRSFPNDDVMSHQSYQQANMGHDGYWSGQPSAPSAPSAPSAPSAPSAQESYELPGQSPRPGLAQPAQGQGGYRGVDPEVPLHQRMEGRVPYRPGHLGASHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1Y3</accession>
    <name>A0A1C1D1Y3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1Y3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02972"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04807"/>
    <dbReference type="eggNOG" id="ENOG502QQX4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5409522at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="425" mass="47636" checksum="971D0CE531C61B87" modified="2016-11-02" version="1">MASHRVQIQLSQHLALNAENIVVTPTAPISNILPNPPYQPVFPTYSMDYRAGIQVVRQAIPARPADGQGTHHTYHMATHGNLHPILLQMEPAPNPIAGVVVPGLVDEATNQFVRGNDGTPLRYFSHLPRWVHHDVSGMLIELWMRLDPRVEMRDILNRINAHPTKKTIGPSGYNMKRSRFRETIDVPPFTTGRQHPCSFEIDVINNQTREQLLLNTCMLVDLPSNRMFKPVMASDRVILGYVDSCLPLDYFLRGFPTPIPLPSDRQNIALQLRSRLQTLAIRCNLGNQPQNYKNLPENLKPTWWQKSQEPQGPLPIHQVDSLTHNEWIAQLCRQYPGMSRSGTQRTNSISPAPVPTPVAFVPSAQQALGPPSLRTPPAPVAPLPAVDQDLANPARPLVGEWHERNSGGGISYYVEPAHRRPGRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D213</accession>
    <name>A0A1C1D213_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DCW1</name>
        <name evidence="14" type="ORF">CLCR_02931</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D213"/>
    <dbReference type="STRING" id="86049.A0A1C1D213"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02931"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04919"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF41">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651214" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="26"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT54827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="460" mass="50213" checksum="655A54B70F1EA6AF" modified="2016-11-02" version="1">MRPFRRRPLLHLTLSALLFTQNALAIDLDLSSPDSIKSAAKIVADEMVTYYTGYRPGDVPGNLPAPYYWWQAGAMFGSLIDYWYFTGDASYNEITTQAMLHQVGPDNDFMPPNQTKTEGNDDQAFWGMAALSAAENVFPNPPSDQPQWLALAQAVFNTQAARWDTMSCGGGLKWQIFAFNNGYNYKNTISNGCFFNMGARLAVYTGNQTYADWADRMWDWVTAIGLRDEQYNFFDGSDDNLNCTELDHIQWTYNAGTFLVGAANMYNYTDGSQVWADRISGIISRLNVFLEGNIMKETACEAVNADGSDTCNVDQRSFKAYLARWIAATIVRAPFTYPLLKPILEQSAAAAAATCTGGVNGTSCGSKWWKGAIFDGETGVGQQMCALEVIQSNLITEVSGPVTEGSGGTSQGDPNAGTSSPIGPGDLHRHEVTAADKAGAGILTVLLIFFIVGGAWWIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2D4</accession>
    <name>A0A1C1D2D4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2D4"/>
    <dbReference type="STRING" id="86049.A0A1C1D2D4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02947"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05014"/>
    <dbReference type="eggNOG" id="KOG0565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF286">
        <property type="entry name" value="5-PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT54922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="456" mass="50385" checksum="6C1B1A1390979DDB" modified="2016-11-02" version="1">MAEPTQPEQTDALNIYILTYNCARTLVNPSIFAPHLFHGLPANSLSPEFLVICLQEFAPIGYAFLGGSFLTPYFNAWRHIVRLASSSKDHSYVNVISRNVGMTGIMVFARDDVADHVKWLKTAGIGVGLSEMGNKGAVGLRIGYQSPGMASEVEFTFVSAHLAPMEDGLERRNEDYKNIVRRLVFVPDPGSKKPVSRDEEDEDAPLLQGNDPSQQVDEAFESGMYASSSHLFFAGDLNYRTSLLRPSPQDVDEKFPHPTTNEADPKHFQQLLAEDQLTQQVKAGKTLHGLSEAPITFPPTYKYHTDGSKAVIFANGEEDDRQHWSWARHRWPSWCDRIFFWNDRGSSGDVKVTPQKYTCLPLFASSDHRPVVLAATVPLKALANAEEGGEGGRGPTAAPFDIDPDWRSKRAQARRKELAVGLMAYLALTWEGNGLLLATTIGAIGGWLIIRSLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2H7</accession>
    <name>A0A1C1D2H7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_03197</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2H7"/>
    <dbReference type="STRING" id="86049.A0A1C1D2H7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03197"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05025"/>
    <dbReference type="eggNOG" id="ENOG502SBXP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="14" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT54934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="92" mass="10348" checksum="0549F317047824F6" modified="2016-11-02" version="1">MAPPNNPTGFSMKTFTDAATSTQWRAKDPWKRNEAWRYTGPFTRGNRMKGAFPGFGIAVVAFTGYVIVEQLFFAKDHHAHEHDESAGHHKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2M5</accession>
    <name>A0A1C1D2M5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_02766</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2M5"/>
    <dbReference type="STRING" id="86049.A0A1C1D2M5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02766"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04986"/>
    <dbReference type="eggNOG" id="KOG2007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000186">
        <property type="entry name" value="Putative Cysteinyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="13">
        <location>
            <begin position="31"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="712"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="712"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="783"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="797"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT54895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="836" mass="94191" checksum="3CD7557AABCDA070" modified="2016-11-02" version="1">MAQPAWSLPSGSTHQPQLKIYNSLTRSKVPFVPVQQGKITWYACGPTVYDDAHLGHARNYVTTDIIRRILRDYFGFSIRFVMNTTDIDDKIILRARQRHLYDEYKNKHRYIDDQVRQDARHAWHYYIHRNLKRINPKTLVTPENFDGLIETIYGDILAGGSLEPGTKPGDKEAKIKMHINTARGTARALMQDPKLLTPHEFYNRVSDVMCLVLDEQLGKTIRGDDYAVFTKLTKEYEQRFFQDMHDLNVMDPDDLVRVTEHGNEIAEFVKKIVGNKMGYRTADGSVYFDIKAFEAAGYPYARLEPWNRNDKELVADGEGALSQTEAAFKRSDADFALWKSSKPGEPSWPSEWGPGRPGWHIECSAMASGKLGSQMDIHSGGIDLAFPHHDNELAQSEAFWANHGQWVNYFLHMGHLSIQGSKMSKSLKNFTTIREALHVRKDWTARSLRIVFLLGNWKDGIEITDDMVTQGRSWEDRVDNFFLNAIEAIKESKATSDQKATLQAALQEAEDRVRTALLDSFNTPIAMEAISQLISIYNSAKKSDLTPRDHHDVAIFITRLVNIFGLNGSEPADTEQVGWKGIEIPDAAKEFVYPLARIRDELRQAAIAKSITVEKVQEIVSTSPSGLDEPPTVGRPRPSYARALSEFNRDALQAASSPPSTNSSSDLNKQILALCDRVRDVDLWQLDIYLEDRENAPALVRPVTEGLRAVRREREDKARAKEEAKRQREREAQERLQKGKLSPTEMFKPPHSSEYSAWDGDGVPTTGRDGQPLTANRVKKLKKEWEQQRKAHEKYLAAVGGSSAAPGANRDGSGSGPAPQQPGDRVTVAGAEVDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6J5</accession>
    <name>A0A1C1C6J5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6J5"/>
    <dbReference type="STRING" id="86049.A0A1C1C6J5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00699"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01035"/>
    <dbReference type="OrthoDB" id="1670005at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT44096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="182" mass="20072" checksum="630BABCCD7175076" modified="2016-11-02" version="1">MRLRDVQRLELPPSADMHTEIIPPGLQVMELVVPQILKGGVDTVFVMPNLQPPITSVAQALEYQSRLQAIAPKVHYLMSLYLHPSITPEVIAEAAAAGIAGVKMYPQGVTTNSESGVPADFLDAYSPVFAAMEQHDLVLNLHGEWPGQLPSDDISLEEAFLPQLMRLHEKFPRLRCVLEVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6Z5</accession>
    <name>A0A1C1C6Z5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CDC31</name>
        <name evidence="7" type="ORF">CLCR_00690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6Z5"/>
    <dbReference type="STRING" id="86049.A0A1C1C6Z5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00690"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01160"/>
    <dbReference type="eggNOG" id="KOG0028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF48">
        <property type="entry name" value="CENTRIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="247" mass="27941" checksum="223BEC8635A4B62A" modified="2016-11-02" version="1">MSQGNPAFPARNVYASSSKLPDRTAQRPGATAPSQQYTQSTFGRRPDHIYQYAQPTAPPVLQQQAHAMPAGRQSTEKEPNALSELSEEQRDEINESFSLFDLDRDRHLDYHEVRVALRSLGFTVPKAEIAQIMHRQGVPKPKFKRGPTGRGQQSYHVSQLLLAQVPFQRIAAQKIFERDPTEEVERALLLFDPEQRGYVEIDDIRRVARELGETGLTDDEIHAMVEEFDYDGTGSVAKEAFYAICLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C740</accession>
    <name>A0A1C1C740_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibronectin type III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C740"/>
    <dbReference type="STRING" id="86049.A0A1C1C740"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05401"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06983"/>
    <dbReference type="eggNOG" id="ENOG502R2RI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5572782at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="59"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="940"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1085" mass="119990" checksum="7D5E0A1DE24F793D" modified="2016-11-02" version="1">MPALPVSWMDSSRWPQESLDWASYAYQHLAPRSRLLYRAYQVLTTSNEILIEKLGLDIPPAPVLILEGISSQEIHLSWKYAEPSSSVQEHHVELNGSLVGTTKKTEMGAVISGLCPGTKYAVRIFCISTSTFQTPSAALHVRTHYLPEDIEAPEFDPTVKGVPVRNASLSAPLAAPSMTRDLSGGQPPGRRGTTGRRPSPAGYVVDAQAQDGPRGEEDEEDENLAELSQKFQKIQQEIDGVEALIEEEDKDFEANMRVLEARRDELKQALKERDEQASDLRKQVNKAESLSRTAQSEKTKKERLLQQKENERRKRRDDISRWEEATAAMKEEIAGIEKQKAAIERRTQAEIREIRRKIEEEQKEVAILEEDNKEKALQIKVLEDERQLQNADEETDETREVDRLDRERDERWRARFNTMQQTYANLWAELQFVNQQVMYTRDQIKQVETRKANTMAFTPIAPLDMDAIRRGNRPVRRPRPAGSLGSSISSPRGPFAGPEPFPPGLHYASATTSSPTSNAQGYFNFSNGMTLTVPGEMAPSTHDDLDTISSIPMSPRADSLLPADLLGDESADDIPDVELPEPKEKPETGITPFPKIGSPVLHPDSGRTESPSVGSSSGQSFSSPMQTSAPVEADEKSSSSDKKSEEQAEEDEVIQQPKKPKYTSMSSMFGLNRQRGKTLADQPPILGSLKPGQSQSFPRNVEGFDPRLEPKRRLSYGGNWAFPGSALLHSSEAEEKESAMSRFAATRRAFGFGGFGKSAAASANYDPFAIRSASFDPGLRGDTSSPRPASTYSFDKLPRPSMESQFRAWNDKTVLRNSPLAPEWGSLHSYSRSHSRRPSIVHGSTSNLSLAHGDEEVIEPDRKPSRPLQAPIGTRPASSQQSSTPKLNPAAPSFTTLFGRRSDKGKEKDKNKPKESKERVNDLEAGSPPESRKSKDANSLAATVSTLDSETLDRTQSATSAQLSVENAPAKPTFISKITRKASSNKFGSWKEKGGGLFSRKDAATPNGDNEDEQGSTDNLGKSLESISTTPTTEEKKASRTSLSNWNFMRKSKKGLKEDLTASEISESSERASEIGEERDDELEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C794</accession>
    <name>A0A1C1C794_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fungal Zn binuclear cluster domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C794"/>
    <dbReference type="STRING" id="86049.A0A1C1C794"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05669"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07030"/>
    <dbReference type="eggNOG" id="ENOG502R6NR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="542" mass="60090" checksum="D8D4CBCB98999550" modified="2016-11-02" version="1">MDMPAAGEEPLKGAKPPDLLMSPELQRRLDNWRMSGESPLQELQVPDRVYWTRFSTIDLRLIHHITTLSTDMYNRGYSTCTAWGSKIPSLISAALSHDFAMSALLALSASHLAWQTKNPDTDNLAYHHRGVALKGLHEAIGAFSRENSEAILAASILLSWQATDWRGWASLQQGVSTVMSAMRQWIHESDLARYLENQRTVARARTPATPTMPHAQLSIPHEDLRRVEQITTALHNLRLRLSTSEELAEHAGRLVDYLQDLQRDLSTQAPEQAFVRLQPLRDLIFWLPPLILRAGESDLAPLTLLSHLYASALAIEPLFPDIGGAYLGSMSVLPLERVHDMLRTRRTTQPQDTSIQVALSLIDVPVQIMTSYRLRQRHNSQSGQSIEGYRYSPQGSPYAAPRMPISTSDVPIAPLYSNSPLHAPGILPLPGSAYFQAALGPGEPRRESSMSSVSSLGRTHSMSDRSLASGSPHAMAMVYGSPAAQHPRSNHELPGSRMDYFGQIQAPYNPYGSLNMNTRTPPATTSPSLQQSQQDKGKERQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7C1</accession>
    <name>A0A1C1C7C1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_05389</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7C1"/>
    <dbReference type="STRING" id="86049.A0A1C1C7C1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05389"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07081"/>
    <dbReference type="eggNOG" id="KOG0308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001614">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="657"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="765"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="823"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="955"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="673"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="729"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1075" mass="116689" checksum="1B85277B4B4814DC" modified="2016-11-02" version="1">MAKKKRQRISYVLPLAASPGGHRLGVNGLAFDEDRDILYTGGRDGVVCAWNLDLEAQRSQQDAGTKDKKGTVSFRKQVQAHTHWVNDIVLVKNNLGLVSASSDVTVKLWRPHGHETTQAYTIGSHSDYIKCLATPDRTANWVVSGGLDHKICLWDLNGAGKNLEIDVGKIQDVVKGSVYALRARGSLLASGGPESVVRLWDVKSGKSITKLVGHTDNVRDILISDDGDTLLTASSDQTIKVWSIAAGRCVHTLTMHNDSVWCMYSDDPNLAVFYSGDKSGLVAKTDTRRAMEIDDGVSVAICQEHDGIARVLPVGDFVWTATSSSSVNRWLDVDTELDVETPPSSPREERAASPEARKNLSPEDARTESPTSTKEGMTNGTTNGEVDHNKKIPHTAILRVSNTALLPGRKNLGRLPNASATNLRKASEVMIADDLSLVVPVRGQPAETIEGQNGLIKHVMLNDRKRILTLDTAGEVVLWDLLRCTPIKSFGRRHLDEVVPEVNTTESVANWCGVDTKTGKITVMLEENYCFDAEVYADEVDLPDNVHFREDQRINLGKWVLRNLFSKLIDEEIARDEEHRRTLQSKITPPPSTGLIRPGAPTSIAMPESVGTTPMVSPGTAATPRANGLGRIPPTPGLAIGAATPGFAPLSTTLSTTAEEDGAATPNGPALTPRTSTPKVHTPRVQQTPSATESQGVDYFSSSTTTAIDQSEASSDSDKVPKTPGIGAENNTGTVSTPTSPTEEKKKGLFGKKFGMGMSLGKKMTTRTSAEVKAPVASAEEKLSDTASMRSSDKETEKVHNIEDNFFGVVQKIRLEYDEHIEHRPDQPLPPGITPSPSSETPVLAPPPHTTIIIQEDNPESGGLADQYRGEISELGNPSEVDTLEKIAPMWLGDLLLRNQIPYKDTVKVSFVLHPYDNLLPAIASPDGNARLNANRMLRAKKIMAYVAERIEAPAHAPIAPPPDTAQSSATHTDSEPPPPAQQASEAGPTEIPAPDSEQENAEEQLKPEEYLELYCQGQRVDPNTTLATLRVHVWRIGGDVVLYYKSNGRKELRLPHPAQVPTREESEETTGVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7C8</accession>
    <name>A0A1C1C7C8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_05880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7C8"/>
    <dbReference type="STRING" id="86049.A0A1C1C7C8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05880"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07122"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001190">
        <property type="entry name" value="Short-chain dehydrogenase/reductase SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF15">
        <property type="entry name" value="OXIDOREDUCTASE UCPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="288" mass="30284" checksum="F53F943B5EECFD35" modified="2016-11-02" version="1">MAPFDFTGEVAIVAGAGSRLPGGIGNGRATAILLARRGAKVALLDINEDWANETKRMIDLEGGTSVVIRTDVTDSESCRAAVATTVAHFDNSPVHILVNVVGVGGAMGDATTVDLAAWDRDMRINVTSVVLMARHVIPEMRRGGRGGVVVNMSSVSGLLGGNPSLLYPTSKGAIVQMTRAMAAQHGEEGIRVNCVCPGMVYTPMVRRGGGMSEEMRQARRNQNMLKTEGTAWDVGYAVLFLCSKEAKWITGLIMPVDGGTTAGKSVSDRPALKADVLAEEMTGIPNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7L9</accession>
    <name>A0A1C1C7L9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable glucan endo-1,3-beta-glucosidase eglC</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Endo-1,3-beta-glucanase eglC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Laminarinase eglC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">eglC</name>
        <name evidence="23" type="ORF">CLCR_06171</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7L9"/>
    <dbReference type="STRING" id="86049.A0A1C1C7L9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06171"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07215"/>
    <dbReference type="eggNOG" id="ENOG502QQE6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF13">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE EGLC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OCT44533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="289" mass="31038" checksum="9EFC09E0E15BE30E" modified="2016-11-02" version="1">MKSSQLVALAAATISGADAYFRGFNIGANLPSGACRSQSDWEFAFNKIASFPGNFKSARLYASSDCNTLANAVPAALNTGTTLLVGVWTEDNNHYEAEKQALLEAIQQYGHDWILAVSVGSEDLYRGDTDANTLASQINDVRGMLWGLGASDKSVGHVDTWTAWVDGANTPVIEAVDWLGNDAYPYWEGVGIDNGASSDAYWAAVTKVRAVAQGKDVWTTETGQPISGDTVGNAVPSVESLQTYWWQVSCASLNSLNYFFYDLDDFNASPSFAVVDSNYNPLIDMSCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7N1</accession>
    <name>A0A1C1C7N1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7N1"/>
    <dbReference type="STRING" id="86049.A0A1C1C7N1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05970"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07224"/>
    <dbReference type="eggNOG" id="ENOG502S41G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF4">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13527">
        <property type="entry name" value="Acetyltransf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="203"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="402" mass="45278" checksum="538718C900682C7F" modified="2016-11-02" version="1">MATPNAHSFASLPASQPPVIDADSLPSAQSTALKLEPATLLEYVQTTYLNADEWKGPLTIEQYLQREDILQAVDLTKDARITGWILTSDSLPRNTDGSRPILASCESIPIHAYVARDGVVEKVQAHGVASVYNRPEHRGKGYASRMMAELGKRLETWQSPNGRTNRFSVLFSDIGQTFYARFGWKVFPSTHIHLQQINRLAHERATSGLPAVEDLSLEDLKTIPTTEYVERRLQEISTAEPGKTYVAIRPDLEHFEWHFARDEFQTNVMGKRFPEVKGAIHRSTGLALIWCRVYAAKKSDWQLHILHTVVPPSMQNSQEAEAVMAALLARAQLDAHEWEMAGGVEVWDPSDLVVASAQRLRTEEQGKVDIITRDKEHLCSLRWSGEPGEDVVWLAKEKYTWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7N5</accession>
    <name>A0A1C1C7N5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7N5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06432"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07188"/>
    <dbReference type="OrthoDB" id="4154127at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT44506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="85" mass="9358" checksum="CEF4FA62CBDA6702" modified="2016-11-02" version="1">MAALGKFRASMMKKIDWLKGKLKRRSAKAAPKEEKKLVIGNPTNFRREEVTLGVDCQGKPALVEKAREDAQSMHNAAKAAPNPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7U8</accession>
    <name>A0A1C1C7U8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7U8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06352"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07219"/>
    <dbReference type="OrthoDB" id="5304315at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT44539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="144" mass="16354" checksum="B3467D0EEB334B7E" modified="2016-11-02" version="1">MGSITETDTKYTTGVILAVTQKSEGEYEVNQVEGQDRIPPPPGGITELGSRRYIEYDKKPVYCKGYYEPSSFQISIQIHILGVNIGSYTSNLNNVSLSISININSAKGRMKCYRHNNDVRVQIEIRNKPGHGDQQWQWDDRMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7W6</accession>
    <name>A0A1C1C7W6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative prefoldin subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7W6"/>
    <dbReference type="STRING" id="86049.A0A1C1C7W6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06391"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07231"/>
    <dbReference type="eggNOG" id="KOG3501">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="127" mass="14167" checksum="378887A1901DF4CB" modified="2016-11-02" version="1">MAIPNAALQKLLQEVEAQAVLSQQKITQTQAELTAKRRDARLNQLTSNELKSLSKDTNVYEGVGKITETSSSRFVAVPMTALNERLATESAALQKDIADLDKKLHYQETTFKNSRQHIEKILQTGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7Z3</accession>
    <name>A0A1C1C7Z3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7Z3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05609"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07273"/>
    <dbReference type="eggNOG" id="ENOG502SMPB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="63649" checksum="C61F6166DA19C2CC" modified="2016-11-02" version="1">MHRRQKYLRRLETVEDVLRQHSIATASSARHASDPFEQSPTTPTATDRESTSRASARESQQQAIGFEHPADNVSRATDGQPGLENPEVPPLTIPLGHQTSLSSLLTLPQMRSLVGDFPEEFVFLVEEDRPRALSLQDILAAPGEANQDWRNRERSVADDCLARYHSAVHLYRPLFEWEGLKSQYDKTMREGLSDSSWSALFLAIFALGITASDPIDPTRLRCSGDELIKQSLRLLFPSWAATFSGDLVLSQALVLCSLYFCYVAEPLMAWRLVHMASTSVQQMRKEHLSQQTHDGVTRVGWTCFLIECDILAEFHQPRSGIELLVDRMPFPTYDDATASESLYSLADISARSLSNRIHHTMYFTDGISLYMGRSQSSSGTLPGYPDVSLLRVCEELARQLLTWYESLPNVIRPDLSGTYKGSGQACVLRLRYWSARHNIYRPFVIYVTSRTADQEVDVPTSVLERCKLCLAATRMFILSAGYVLSARTPYTFSTTQCVVSYALILALAAQSPILADSVDDYLELLETAVGLLKPWAVSGSGIECGLEIISSVYRKQRLRSNRIGRTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C905</accession>
    <name>A0A1C1C905_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Autophagy protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">atg16</name>
        <name evidence="5" type="ORF">CLCR_06308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C905"/>
    <dbReference type="STRING" id="86049.A0A1C1C905"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06308"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07597"/>
    <dbReference type="eggNOG" id="ENOG502S5CU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8949486at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="4">
        <location>
            <begin position="7"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="145"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="212" mass="24196" checksum="6EC4786BCBDA7F52" modified="2016-11-02" version="1">MATWREQYLAALQARDEVEKANLDLYDYCTKLADERAELEKKVRLAERSSASEDLPAVPEPVTTPGWGIRRVTSPATRPESPNSGATQLAQLRQDLSKAQSERADLQTRLHTALRDLETFKSRTKVDNKRITQLSASVSQLTIKVRDREEELRGKAKLIENVQDENVTLNLQLNMAEEQSAKLKRENQELVDRWMARMGKEADRMNEEGKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9Q8</accession>
    <name>A0A1C1C9Q8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methionine synthase, vitamin-B12 independent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9Q8"/>
    <dbReference type="STRING" id="86049.A0A1C1C9Q8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05724"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07921"/>
    <dbReference type="eggNOG" id="ENOG502SJYA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7772923at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF2">
        <property type="entry name" value="SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="2">
        <location>
            <begin position="213"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="448" mass="49680" checksum="31F6FFCA7CC12D33" modified="2016-11-02" version="1">MAPPFRADQVGSLLRPKSLVEARRKALLPRDNLRAGSRAGEGEDDIPAAAATGSHGQGHDQDGDTDVDAAAADPVKLLKAEQDRAIKAVVSEQLARHIVPITTGEYERSIFYGNFFESLAGFQMRYTPMEAFRTGFPTNRPLLEWGVPGRDAGFPTSNPVQLAKPAYLDDWLFLRSLLPRDRWADAKMTVPPPGWWHIQLKEPFDRAVYASDEALLRDLSAALRTEILTLYDAGLRVVQVDDPNLSFFCDEEWIATCKAEKVDLDRLLELYVKSHTDAVADLPADLTVGVHICRGNFPNGVGLASGSYERIAKKIFTETPYTVFYLEFDSPRAGDFTPLKYLPVDKAVVLGVVTTKSAEMEDLGALKDRVYQAAEVIAQGQGEGRTREDALRDNLAVSPQCGFASDHSEGGVGMTRETMWEKLELVKRLADEIWPGWNPRWPAVARTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA30</accession>
    <name>A0A1C1CA30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA30"/>
    <dbReference type="STRING" id="86049.A0A1C1CA30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06248"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07980"/>
    <dbReference type="eggNOG" id="KOG0816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="125"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="250" mass="28094" checksum="E61BC53CC5FD7F7C" modified="2016-11-02" version="1">MPPSKRNRIVPTSKVRKNHKELVRRLAANAQDAAEKYSYIWVFDVENARNNFLKQVRTDFSDSRIMMGKNKVVMVGLGQTQETEVVPGVSALGPYVKGEVGLLFTDREPSEVEEYFADWLNLDFARSGSTATREVRIPPGEIHTQYDVEGGEDDPLPVQIEPTLRKLGVPTRLVKGKVALEERPEESMDDEEGYLVCKEGDILDSRQTSILKILGVRMSEFRIGLRAVFDKNTSSVRQVGAMEVDDGDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA77</accession>
    <name>A0A1C1CA77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_05719</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA77"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05719"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07986"/>
    <dbReference type="eggNOG" id="ENOG502QU6S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1288932at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF3">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="41"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="324"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT45352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="566" mass="59545" checksum="8EDAFFC984CA71EE" modified="2016-11-02" version="1">MSDAALAYHEPDIVTILKQSSFLLVLNILGFILDHVFYCGLVGQVLIGMAWGAPGAKILPQLFQETVTQLGYLGLIMIVFEGGLAASARSLGRSVLLSISVALTGIAVPMALSFSLMGISKATRLQSFAAGAALCSTSLGTTFSLLKTTGLTSSRLGTVLTSAAMLDDVVGLALVEVISSLGTGRASLTATTVIRPVFVSLAFAIVLPVGCRLILKPVILRCSTALSQAATRSRFDSLGFSLQLRFIFSTALLLALVTSASYAGASNLFAAYLAGAMSSWVDEVSVQACTSRSDDIAHTEAEGKEGHTTITTGIGEGAITPAQAASHNPGLVDDTTQKDPTLPQQPFKSSCGLGPPPNDQAQSTTVPADLRGNLDRESRTMEMYKTYYASAVDRVLKPFFFASIGFSIPISKMFQGPVIWRGLVYAALMAIGKLCCGLWLVRFTTLSSGSPKTVPRAVASPSGPMDPKSKQKKPPLHRSLPQPRSLYPASILGCAMVARGEIGFLISALAATNGIFTSHDSTTHGEDSSDLTSGVIPDRHVGDSSVHDCWAFIARFPGKESQEAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAJ1</accession>
    <name>A0A1C1CAJ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_01580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAJ1"/>
    <dbReference type="STRING" id="86049.A0A1C1CAJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01580"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03384"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650669" description="Plastocyanin-like domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="213"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="421" mass="44445" checksum="81E287307BC8004B" modified="2016-11-02" version="1">MRSFIFVAAAAAGLANAHESATWTSDVTVTATSTRTHTFCPVTQATTCDAADATDVSGNHGHHDGIGASNAQDAWWSIWQSAKTNYGVWDDWNTASETASATASATTTDTGSGNGGHGSGPSSSYSYSTSGSGSGPSSSYSHSYTASSSTSASATSTTSAAGCPTYTPAHNETYDYCNSAYDRSKWCDEKSIKTDYYTNDYDTGVTREYTLEITNTTLVYDGTGPKLALAVNGQVPGPVIEANWGDTVKVTVINKLQDNSTSIHFHGIRQFGTNDQDGVPGVTECGIAGNGGSRTYTWKATSYGTSWYHSHTFAQYGDGIRGPIVIHGPATANYDYDMGTVMIDDTYTNTAAAQAAVIAHFGPGGSFNTLFNGKNKNPDPVGPGGAPFSWGLKPCRKHLFRIINRLVLSSPGEIIIWLTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAM6</accession>
    <name>A0A1C1CAM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">IMP4</name>
        <name evidence="3" type="ORF">CLCR_01670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAM6"/>
    <dbReference type="STRING" id="86049.A0A1C1CAM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01670"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03403"/>
    <dbReference type="eggNOG" id="KOG2781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140691">
        <property type="term" value="F:RNA folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="86"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="296" mass="33367" checksum="04E039256CC9F1C7" modified="2016-11-02" version="1">MIRRQARERRDYLYRRAIQLRDASIAEKRALLKKSLATGKPLDPSIANDKSLRKDFKYDESLDPETAAAKESFDDEYSMLSGLADPRPLVTTSRSPSTRLATFSKEIRLLLPTSIRLNRGNLILPNLLASAKAAALTDIILLHEHRGTPTAMTISHLPHGPTASFSLHNVVLRADIPDASRGTVSESYPHLIFEGFTTRLGKRVVQILKHIFPPRDGPHKVGNRVVTFKNVEDSIEVRHHVFVQTGYRDVELAEVGPRMTMRCFEIRGGTLEKNSGGEVEWALTQYTRTSRKKDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAN9</accession>
    <name>A0A1C1CAN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate system cyclin PHO80</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAN9"/>
    <dbReference type="STRING" id="86049.A0A1C1CAN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01615"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03456"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF117">
        <property type="entry name" value="PHO85 CYCLIN PHO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="371" mass="41129" checksum="54CC56F43D18C07C" modified="2016-11-02" version="1">MLATSLSPNISPATARETGVALYSTSPRIHYEKSASLSASSRSATVEQTSPVARKRPLSYDIDFQKPRRLPSTKSLDRYGYSPRVQPRPKMVDASTQYSPPNQQKAAQTPTSTIAGLQLSEKEDHSPKAALLSSATKRRDGTVPSQTRPEITTAQAQIKRHAVEPATAARTPVNGVVPEEEPSVEQSPVKKARPDAPPVRIMPLQYENCNTRDLVVLIASMLMELIRYNDAIPLKDGQLTRFHSRAPPGISVLDYLQRLTTHATLSPPILLSVVYYIDRLCALYPAFTISSLTVHRFLITSSTVASKGLSDSFWTNKTYARVGGVSMKELALLELEFLTRMEWRIVPKSEVLVDYYKSLIARNSQYQLEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB78</accession>
    <name>A0A1C1CB78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_01739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB78"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01739"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03657"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="123" mass="13904" checksum="229440F303EF917E" modified="2016-11-02" version="1">MDPPEVEADEFEIEEAEKDPDEMVFDRCLEDFRELVISTCQHNMYTLAASGPRPNSRQASLEDFLHPPTFYLQLHTASGKLEAVEMDDISETALRDDSVPLAADFEPQSVPIFTPCSNVDFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBL4</accession>
    <name>A0A1C1CBL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBL4"/>
    <dbReference type="STRING" id="86049.A0A1C1CBL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01562"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03749"/>
    <dbReference type="eggNOG" id="ENOG502SEBV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012578">
        <property type="entry name" value="Nucl_pore_cmplx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003:SF1">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08058">
        <property type="entry name" value="NPCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="47306" checksum="82017ECBED895370" modified="2016-11-02" version="1">MQLATAKQLPDSADRQQRSLRCASLEPRQPPVDRHDSVRNNHVKLTFRQFRYGNMSTTTTSLVPSPLSSSYSTALQTTQKAASQASQAVTAATSQVSQQAQSLGLTTPKPASVSTPASTPGIFRHPLTTEILRRNASSTITERHVKGALTNAAALLASFIFSDVYYSRSVGAGFLTQAQLITVLSVTPLLSKTGLLDGSQVSSTVLLLVRLLFCINIALLLRPVLPYAPDRDEVNDIPLTPSQRQLLGLAPSTKSTPASGDLPASYITPPRYRRVSNSQLSGESNNGSPHASTGRRSISANYSSSPLSTSRFTLGFSPTPSQSVTARRTTSGSPFSGSPSASPLFHRAVNNHSQSQISDVDYNASAYSSFGTSTSASTHPGFGGGSLSRSQSMRERQRPGRDNLEPTSPSPTRGPQVVPGLNYKWLYDKGRKLPKSESSYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC48</accession>
    <name>A0A1C1CC48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative amino-acid permease P7G5.06</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_00400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC48"/>
    <dbReference type="STRING" id="86049.A0A1C1CC48"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00400"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09984"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="44"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT46032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="569" mass="61936" checksum="DA2A002C8EE8E2FC" modified="2016-11-02" version="1">MVNTAYGEKVADDSKEATPTDLGHDVEEGTHEPAKLSRGLQGRHMQMIAIGGSIGAGLFVGSGSSLQSGGPASLLLGFIIIGVMLLCTVQALGELAVLYPVNGAFYVYGVRFIDPAWGFAMGWQYAIGWLITLPFEITAAGNDPFSWNRAHRSYRKLTEREGLTIDYWHHYNIGIWIAVFLTTLIIVQFFGVKGYGEVEFVLGIIKIIAVLGFIIFGIVVDCGGVPGDDRGYIGFRYWNDTEHGNRAFRNGFKGFCSVFVNAAFAFGGTELVGLAAAEAANPRKSLPKATKQVFWRITGFYVVSLLIMGLIVPNSSPDLLNSSGANTKASPFVLAIEYAGVRGLPSVFNAVITISVMSVANSCTYGSTRTMQALAQGGMGPKFLSWIDKKGRPVWPVVIQMAFGLLAFINEAETGATVFNWLLALTGLSSFFVWGSICLSHIRFRAGWKAAGRSLDDLPFRSQVGVYGSYLGLFLVVISLAATFYVDLFPIGGNPTGGAESFFEGYIAAPIAITLFVFWKLWTRDTGFLVKVHEMDLDTGRREFQDIPGDDEPEPRHMSVGRRVSRALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCK2</accession>
    <name>A0A1C1CCK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DED81</name>
        <name evidence="13" type="ORF">CLCR_01146</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCK2"/>
    <dbReference type="STRING" id="86049.A0A1C1CCK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01146"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09267"/>
    <dbReference type="eggNOG" id="KOG0555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000040">
        <property type="entry name" value="Asparagine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="267"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT46253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="570" mass="63925" checksum="685B52B297B4431C" modified="2016-11-02" version="1">MADTIYIDEDVGRDEESVAGSQAAPYKTLLFAMIQHPGASYQTRKSETGPVDANGDPATRLEWKPAAKSALKKATNLYEQHKKKLAKAADLAIRDKEAADKRKAVLEEAKKVILEEDRSLPEPVRIKLNVVDPVQIKLGTADSKGTRVKVFGRVHHLRSQKDVIFVTLKDGKGLMQCVFTGQLIKTYAAMTLTLETSLEVRGELKSLPPGAHAPLDRELHADFFTVIGVAAGDKDAITNKVQQDGDPQTLLDNRHLVLRGDVASKVMKVRAAIEGAFVKTYDELDMTKVSPPAMVQTQVEGGATLFEFDYYGEKAYLTQSSQLYLETCLAGLGDVYCIEKSFRAEKSLTRRHLSEYTHIEGELDFISFDDLLAHIEHVVCRVIDIALADPTVAKFIAELNPDFKPPSRPFKRMRYSDAIDWLVEHDIPNEEGQPHAFGDDIAEAAERKMTDILNVPILLTHFPAEIKAFYMPRDQDDRRVTESVDVLMPGVGEIVGGSMRISDFDELMAGYKREGIDPEPYYWYTDQRRYGTSPHGGYGLGLERFLAWVCGRWTVRECCLYPRFAYRCKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCM8</accession>
    <name>A0A1C1CCM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CLCR_01242</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCM8"/>
    <dbReference type="STRING" id="86049.A0A1C1CCM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01242"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09256"/>
    <dbReference type="eggNOG" id="ENOG502S1H2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650710" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="17"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCT46265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="320" mass="29111" checksum="3E330F897ECC3E58" modified="2016-11-02" version="1">MKTFVAAAALVSVGLAQNLADLPQCGQVCFNNMVAPALVSSLGCAAGDIICLCTSENFGFGLRDCSQESCPPGTDLSAITAYGNQYCANAASSASSAGSSVGTLSATSAMTASGGPASASGAGAGSDSASGGSTPVSTETTFSTITSGGSTITTAVGESTIFGAGGAGGNGGSSTPISTETLFSTGTNSDGSTFTTAVGTSTIFGAAGAGASASSAVSGASGSASSAASAASASASSVAGSLSSEVASASSAASGAGSSAQASASSLASSASSRLASATSAAGSAVSSAESSATGAAMPIATAGIHGLAGVAGLAAIMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCN1</accession>
    <name>A0A1C1CCN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribosome biogenesis protein ENP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ENP2</name>
        <name evidence="10" type="ORF">CLCR_01096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCN1"/>
    <dbReference type="STRING" id="86049.A0A1C1CCN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01096"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09234"/>
    <dbReference type="eggNOG" id="KOG2321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="8">
        <location>
            <begin position="407"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="7">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="506"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="556"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT46290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="725" mass="81422" checksum="2A8679CE82F26056" modified="2016-11-02" version="1">MRLTNGTVPVYTVAGSSINRNLPDWLSQRQKRKKDPEYANRVELLQDFEFEEASQCVRISEDGEWVMSTGTYKPQIHTHYLPNLALSWARHTNTLNKTFIFLSSDYSKTAHLQEDRSLEFHTPGGCHESLRIPRYGRDLAYDRSNTELLVPAVGVNKNGMGEVFRFNLELGRFMSEFEIDVGGDDLNTIGGGALQGGIQVGSVNVAAVAEGSHNLLAFGTSLGTVEYWDTRSRAPVATLAVPSDFEGRPEVTALDYHRSGISMAVGTSSGLIYLYDLRSSLPTLKKDHGYGYPVQYVQYLAQGVKTRDSVTEPKIASADRRILKLWDESDGTPWTSVEPAVDINCVAWCRDSGMFLTANEGRQQHAFFIPQLGPAPKWCSFLDNVVEEMADDPNDPYAFTKTKVGEIYDNYKFLTPPQLRMLNLDHLIGKTNLLRPYMHGFFVAQGLYEEARLIANPTSWEEERAKRIQAKIDKERESRIRGKKKITAKVNRKFLERILEREEKNERRRAQRVLAQGGDDVAPTEATGTVAAQGEDKGLFPDARFARMFQEEDFAVDETSREFQQLNPTSKAPASNLDREKGLTAVEEEAIDEVPGSSDEEDKDEDDFYGSRNKSGTRISTADYKRRPNKKQKKRDQIQMRVKSSGAGSAARTTHDRSFGSRAENLQPVERKQRRAGFGGAVGDKVITFEPTKKSKGLDQLHGGSHRTSRGQDRRSASGNTFRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCU3</accession>
    <name>A0A1C1CCU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01247"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09227"/>
    <dbReference type="OrthoDB" id="4150940at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41558" checksum="FFACBAEB5600E09A" modified="2016-11-02" version="1">MTLLSLPPEILSIICEYTIFDQLGPERRLHPCTNCRYLNRGARRREHACPHLLLCCRHLHTISSQVFYQHVTIVVGLDYHSQPYYFRCYPTPDHDKDIFSVLMARTSILPHIRNLELLIARSISYNPGTQSTCRDMAFRSNWEDLPTVISSFTAHLPSLHTLSYTVGVGALPNEALCIWPHATKTEQIHRFIPDETVFEDTSTWPVPLSYYFSLSTLLQASHAVGLGGRGVNVTRLRLWLTRPRIPGLKQFVRGLSSGDTPGHGGSHPSPGPRSSDDQAHAWRALLRHHTFSKVILQLPRLRVLDVYVPERPSTGADMDGLWEDASIDSAMARTLTRALETAFPHVRTIRLWRAGCENVMSGEYTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCV4</accession>
    <name>A0A1C1CCV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aflatrem synthesis protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCV4"/>
    <dbReference type="STRING" id="86049.A0A1C1CCV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01222"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09174"/>
    <dbReference type="eggNOG" id="ENOG502SHVK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="72269at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="42088" checksum="0B8A03A6A0B10C3F" modified="2016-11-02" version="1">MALSVPKVLLILLSVAGFWTLWGFPYQNGLLKILGHQAEPGAVIPGPTAAPMKQTYTGIGALDKQLTVLVSFFYTAIDGNRADVSLSFLYLGGQVLASWVLVMIEGLRNGNRGKFVLTATTLFGIGVAIVGYACVAPLWFAYHLWTSSTVSNPKDYQLYVDAPVKIALIPISILVGFGLPSILMCLPAPTLVSFDTKQTWTGIQQGWSVWIGLTQLILTIVALNLDQRASILTESDKRTKTVRYLRLAYPFAILSSAGSHLAVLGLSSLAYLFPVLFSAKYLPQLQPDRIFVTVVPFGQPQVQTLADGALWFLQWDIIVGVSAALVWALTLRTGAKHEEATIIQTIVGAVKIALLTVLIGPCGTAAVAVWGRDELVFGRANAETKKGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCW5</accession>
    <name>A0A1C1CCW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like (PK-like)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01231"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09219"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="123"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="391" mass="44839" checksum="643DEA79C86DC6EC" modified="2016-11-02" version="1">MIDYEDGNAPVEHDYTHPERHLKLASGEIPDEYKRAGWRIDHHIDKELCWACGWTTYEQSQGYSPRVKIMCVNRNRGLWSLGTKWLVCDRPNDLTLGNDYMTWKFLHDHAGPDFPVVKEMRRLNDPKDPIQITLISRAQGKLLGSVWDSLSLSQKSSYRDQLVDILRKLRRFTAPLIQNVNGDQLYDCVLCLCKGFRPPTCFKVGFTEDEWLQDMSEHLRSGLSSIHKTRDPKVIEEKLQAIKDDFPRGGPYVLTHGDLHVDNIIVKDDKIEAIIDWETSGYFPWWAERINAGRFASRGWDLFDGVWARVHPDLGDEAFAVTLKKLEPLQNAVEAAPQSHTSTRPVLWRPPFCECRPFGGMISNSDLGSPDEHVELDWRGGVKTISAKSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD67</accession>
    <name>A0A1C1CD67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldo-keto reductase ausK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">AAD14</name>
        <name evidence="6" type="ORF">CLCR_01922</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD67"/>
    <dbReference type="STRING" id="86049.A0A1C1CD67"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01922"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01205"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19147">
        <property type="entry name" value="AKR_AKR9A3_9B1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000024">
        <property type="entry name" value="Aryl-alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF2">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="383" mass="42671" checksum="CAF8FCFC473F8710" modified="2016-11-02" version="1">MSTIFAPAPEPPTELGRYRILSSTAGVRVSPLCLGAMSIGDAWSDFMGSMSKEQSFKLLDAFYDAGGNFIDTANNYQNEQSEKWIGEWIKERNNRDLVVIATKFTTGYRSWELGKGKAVNYSGNHKKSLHLSVRDSLQKLQTDYIDLLYVHWWDWTTSIEEVMDSLHMLVEQGKVLYLGISDTPAWIVAAANTYARSHGKTPFSVYQGRWNVMTRDFERDIIPMARHFGMALAPWDVIGGGKFQSKKQIEERKKAGEGLRRMMGDSGQTPQQEKVSAALEKVAGEHGIESLSTIALAYVLQKTPRVFPIIGGRKVEHLHDNIKALSIRLTDEQIHYLESQTEFDVGFPSNFVGESPEATGKSSSMVAGTAQIAYPTPAKAVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDG1</accession>
    <name>A0A1C1CDG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02182"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="96" mass="9966" checksum="CFB1A01DA247CB40" modified="2016-11-02" version="1">MASAFFARRSVTSIDSTTATTPSYLKSTTTTTTTSSSSSSQYAASTSSATSTRPSTGSAKRDIASPSGRIPETDSLSSSMSNSYGSFMRSMYARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDL4</accession>
    <name>A0A1C1CDL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative proline-specific permease put4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">put4</name>
        <name evidence="9" type="ORF">CLCR_01896</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDL4"/>
    <dbReference type="STRING" id="86049.A0A1C1CDL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01896"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01290"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF38">
        <property type="entry name" value="PROLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="63"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT46561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="560" mass="61932" checksum="FB19886FB4CE3316" modified="2016-11-02" version="1">MAEKDYTDPEKGIEPVKNLVSVDEHGGKHSITDRKSSVVESIIAADLLDDRYNITQRGLKSRHAQMIALGGTIGTGLFVGSGQNLALGGPAFLLAAYVIITFLVYCVVTAVTEVAAYLPVHGGTMSYYGYRYVSRSLGFALGYLYWYALGILVPYEITAAGLVINYWPNDVNIAVWMTIMLVVIVALNFLPVKFYGETEFWFAGTKVILMIGLLFLSFILFWGGGPSHDRLGFRYWNDPGAAHPYIVGGDTGRFVSFFQTLVSSVFPFTFAPELLVVTGGEMVSPRRNLPIASRRYFYRLVIFYVLGVLAIGVTCPSNDERLTNGGAGAGSSPFVVAVANAGISTLPSIVNAVILISAWSSGNSFLYISSRALYSLAVQGSAPRIFKACNRWGVPYMAVACSSLFCGLAYLNVADDGSVVFNWFVNLTNTWGMTSWVCCMIVFLRFRKACAAQNVQPIYRNWLQPYGAYIAMVSFTILCLINGFTVFFPSKWSASSFLTAYIGIPIFFLMYFGHRIFFWQDKWAWDPMEVDMQTGLQEVIDAEVPLKKRKGLGRICMIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEV4</accession>
    <name>A0A1C1CEV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEV4"/>
    <dbReference type="STRING" id="86049.A0A1C1CEV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02266"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02367"/>
    <dbReference type="eggNOG" id="ENOG502QUU6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053083">
        <property type="entry name" value="TF_kinase-domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305">
        <property type="entry name" value="SI:DKEY-192D15.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305:SF24">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE C03B1.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="112"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="893" mass="99765" checksum="7C8510311B2C714D" modified="2016-11-02" version="1">MSLWTDERVDETVTSAYVHSHLRPNEQELLQRQLYFGGDLTDDTYLDWILTRAKRFFLILVATGVPDQIFGVIDDSYDDEDLPVIEEAVPDLRLSYEPDRALDKRFYKNQFKFLTRVVGEGEHIRYADEESVPINPVNLKSVVLSLSHDGVDRVRLPTANQQVFIRRRIKLEAPLTEDEILNEIAASRRLCHEHIVSVFGSYLHQGNFNVLSLPAPEWSLKTFLTDSPKSFGALAKQERRRILISWPHCLSNALAWLHSNGEFHGAIRPSNIQVDESFRISLGLLDGEGLLRDRAKPDDIEAYQYGPPERWKRAVTIQSTGSAVVSLPSGSRSGRRAGGNGRLNTTDSNNPARSRSASAAATTYTFQPTSRGDYARLRLSSAGPSDPPPPPIARERDVLSPIDNKSVSSSGTTRRAFDPLAPGRAPSILSSTSSNGKKSGPSLKSPMFVSAPEGRSAVVQTWQSVEHDMFASDIFSLGAVIIDILTLLCKRSYSSFQRHRSSKNRMAGRGGGLADASFHANLGRVFLWAQSLQNEAEKKAKKDEGHVYHAVGPVVQLTLQCLERDPAARLSSEQLERKIGEHIQRFAGIERPHCAIAHRKESSQKNVNIPIRGRNVSDRELTRHRSDDRLRQPCADPPVLYTEQPQPQQQRFLHDVPIVQSPILHTSPSVSTTPGTASVSSLLSFNFDGHSDTVVAESPRSREQPMRRTDTREGVATPVHQVPWSSEQDTPKQKYWNNWHNNDSQVDPRLSFGESVDTGAFTYLNYSTSASSDEGVKYFPRPPAERPPKPPPNRGLPPVPPIPVKVQSAKPNQRVTRMKASNDDFAVLNHISQAAIGGRPLRVDSLPKTLEYDADDYHETIRQTRRPHTAKSSSRSRSRQDHYLLGQGRRQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF42</accession>
    <name>A0A1C1CF42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Meiotically up-regulated protein 14 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mug14</name>
        <name evidence="3" type="ORF">CLCR_02464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF42"/>
    <dbReference type="STRING" id="86049.A0A1C1CF42"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02464"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02330"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF39">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="124"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="371" mass="40491" checksum="E8AB99DA43DEDE3A" modified="2016-11-02" version="1">MASTNLTVLRAGSRLQRTNLPLPLSLSLSLLYARSRIHARTISTTQKSPLAAVASEHVASERVASQHVASQHVPTSHTPPPQPPNFSPEFTFGAYQTTGTTPVTRIRYPKFQSLESERAFRKLHHAAALRWLGYQGYNNEGAGGHVTVRDPILPDHFWINPHGRSFSWMRPEDLVLMGPKGDIVDGQGGNMHSVNPAGWVIHSAVHEARPDVVAAVHCHSVPSKAFSSLGCMLEPINQDACRVDQTLQRTGFFPSQTLTSALRLSFYNDHGIYSGFGGIAFKADEGRQIAAALGNTKGVILRNHGHLTVGKTVDGAAFLFGAMDRCIQAQLLADAACAGRGTTTLKVEHEEAEYTRNVYNDEMVYIMFQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFC9</accession>
    <name>A0A1C1CFC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lactoylglutathione lyase (Glo1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFC9"/>
    <dbReference type="STRING" id="86049.A0A1C1CFC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02611"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02273"/>
    <dbReference type="eggNOG" id="KOG2944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF19">
        <property type="entry name" value="LYASE (GLO1), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="40"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="229" mass="25483" checksum="1866D7B824CFB97C" modified="2016-11-02" version="1">MASSSEQQKQPTPFPHGAFLPNGHQTDPALPPGHPTIGYKLNHFMLRIRDPAKSIPFYVDLMGMRTVFTMNVGPFTIYYLGYPQTDEHRADLAKFGADTAGNLQHTLGLLELYHVHGSEKQEPGYYSTGNEPGHLGFGHLGFTVPNVPKALQRLKDAGVEVVKDLGVCTRESIPITDWENERRVGVEVKGTESEIHPEYAKVFNKIAFVKDPDGYIVELVPQNMDPMDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFE8</accession>
    <name>A0A1C1CFE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02689"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="79" mass="8613" checksum="30B28D92032CDA87" modified="2016-11-02" version="1">MQVGRLGTGIENDVARTSAQGHLVTRSERVECLGLFIAADESETDLQLLRSSQNLGRRRVLHNPGSISSLLASRLVAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFI9</accession>
    <name>A0A1C1CFI9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFI9"/>
    <dbReference type="STRING" id="86049.A0A1C1CFI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02621"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02163"/>
    <dbReference type="eggNOG" id="ENOG502QR8W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2530523at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="218" mass="22462" checksum="8E8F37B4DD0B9CD5" modified="2016-11-02" version="1">MALQGQTNPTLAQQAQIQNAAQATRAAAQPQQPTRQAGANGAASPLSAARERARVTVLLEINTHLLQEVVSLQAQGKAGITPNQGQQSPTSPTSATDPANAVTNSPGDPPKSAGGTPQTAKPPSQEYAECMRRLQANLSYLAAIADAKKKVNGALPAGPAIMIPPPHLPQVAELYKKLNALFPDAAQSSINKAMAQAQSQNATSKAHHALSIPAPTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFQ9</accession>
    <name>A0A1C1CFQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02694"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="74" mass="8359" checksum="62DC79534C8B3D8B" modified="2016-11-02" version="1">MSPDLVYRRSDEVDEIREHGAIRAARHSYMFEKETSKKAITRAPCSGAAFCRLHRNHLLVSPEILLAHPDASQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGL8</accession>
    <name>A0A1C1CGL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CIB22</name>
        <name evidence="18" type="ORF">CLCR_03719</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGL8"/>
    <dbReference type="STRING" id="86049.A0A1C1CGL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03719"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10381"/>
    <dbReference type="eggNOG" id="KOG3466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="18" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="68"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT47663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="106" mass="12476" checksum="D20BAD4A1640AD51" modified="2016-11-02" version="1">MASMSPHVKAVRDLYRRSLKLALDWAVQRNLWRGQAVYIRSLFDANKNITDHRQQRILFNETEKLLDKWKHPDPYRPPTAPGGSKYERNLPAPDLPPPSREFVKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH35</accession>
    <name>A0A1C1CH35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_03594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH35"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03594"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04553"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT47792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="331" mass="37178" checksum="FAD46041B12FACDF" modified="2016-11-02" version="1">MWRDVEVNALTGGCDNPYIHLILLDSLRLPKDRSALRVVSNLPSFQSWKAHWNWPPEALPQKSFLHQLEEGFLGSSIADQGHIDPDNPELEINATPEIRQVITSLLCSRWRLLIRRAQKSISESHAPLAEDLDDITEVLQRKHDFENLKRTLSALIASVKRIPGVQQSSPDIVELMSFESSLEGWATQLEKVSQSLLGLLAVSESKRATQQAVRSKNLQLLGFIFIPISTVSSIYGMNTIEILGKPPQNWNFIVGAFIAITVSALAAAIYDPQIMIRTLDRPWLSSRLSNISRTFPTTRNTSEVGGRTRGRLSPVRGNQERRPRKSQCLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHA5</accession>
    <name>A0A1C1CHA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHA5"/>
    <dbReference type="STRING" id="86049.A0A1C1CHA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03329"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04450"/>
    <dbReference type="eggNOG" id="ENOG502SMKU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="81056" checksum="C0CA5D9EDD281BDD" modified="2016-11-02" version="1">MGLLEDSPVEPETPPPSWSPAKYDIWKKPSRWQICMPRLRTAAKIVCTFIAFIIVIKVMNSAPPPAPPQPDPVPDAVGPSVEEVTEPPPPPPLSEDELMEMTMENAKREQWIWKDFTTHDGLTRGLSHLRACETGEVDCKNKNPHLIRYDGYRHFNEPLDYLVSCIGPRGVPLNESNEDAIWAYPGQANGAVEPTLGSYEASGLDGTVSFDRVGRFQAYGIDQWDANDVEEMKTMSDVDWDMVDWGELQDECVVANKQRFRAVKERPANSIQYSNLRHKHDQVSSKPLSSTLEPGMVNKAKRTAILIRVWTGAKWTADAVMNIRAMIAEASLASGGKYQVFLLLHVKDESVPLFVGEDEPQATINKYIPPEFRSLTEVWNHAQIRSLYSNLAEHAFVGRSPWMIIQWFARNHPEFDFFYQWEFDVRYTGHYLDFFEAVENFGRDQPRRGIWERAGRVYIPAVHGDFETDFRNSTREEDPHHVWGPVSVEGVRPRGPKAPKEEEDNYEWGVGEDADWIGFLPSFNVTGTGWWFRNYLWGYAQGTSTPRRATLIAQGRVSRRVLDIMNYENAENGHHIDAEMFPQTMCLHHGLKSTTFPHPIFADRHWTPEALQCTFNGGPFGQAGGHWNSTFSKWNEYAWTNMTWYYSSAQAMPIYQRLLGITALESGGQEWEDVYGRTVVRPMLLHPVKGAKTWQWSGEDGWLQTKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHS6</accession>
    <name>A0A1C1CHS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04468"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="85" mass="9534" checksum="CC3A15F38CF125CE" modified="2016-11-02" version="1">MPDNSNDGPSRGQHQPLKSETIFARHFVRLSTPTHDAEGRTHSWYTLHPTPRRGGDSGSWRTTGVTGELPIAKLKRERKGENSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI22</accession>
    <name>A0A1C1CI22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI22"/>
    <dbReference type="STRING" id="86049.A0A1C1CI22"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04038"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08319"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="544" mass="61567" checksum="060F405DC999EFB7" modified="2016-11-02" version="1">MRLLNTTTRDLTKFHAQIPPYAILSHTWADDEVTYHDYQYLKDAAELKAYQKPFGFCTEAARHGFEWVWMDTLCIDKTDFTELTEAINSMFRWYQNAAVCYVYLSDFVASADSDFSTSGGRSRWFGRAWTLQELLAPKNMVFYDCHWNDIGTKVSLAPTIGSITGIDRKLLTGEARLNEYSVAQKMSWASLRQATRVEDMAYSLLGVFKVNIPLLYGEGWRAFRRLQEEIMKTNNDQSIFAWRIGALSDQSLSRGILASLPSDFRGSGRVVRAQNRHPMPSAAYALADECLAVDLPIYQGLGQETFLGVLNCHFIDYPDTRLAILLQQVSYSLQDVPDSISQTAPSFGSKGSDKRLHCRRVAQDTLQVVQMEALAKWPAMPLTVSPVWESPEDPSAPKTRFPVIDVSIERELGESGYFLLRTTTLYTEDMTERLFSYIFSNSIAETNSDNLFCVKIQWSESCNHGSPTSIQIKSAADEATLTNWALESVQGPSTDTELEIGGDCGSKRWLVRAHVRHGVKKRRKYQVLALFLKVSVRESRTSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJP8</accession>
    <name>A0A1C1CJP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05308"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="78" mass="8401" checksum="6DFECCA904ACD782" modified="2016-11-02" version="1">MIINKELDPYDARWDVAIALPVVEPKAVGRSGQHSLAGPQAHIVAAEVGSSMVAESRGHRSDYVDEKNTSTAIWCRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK82</accession>
    <name>A0A1C1CK82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK82"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05260"/>
    <dbReference type="OrthoDB" id="4150603at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="102" mass="11592" checksum="5BFDB6E9578B2B66" modified="2016-11-02" version="1">MSLMSEEVFSASNTKKAYFPTDCNPVKVMFAFMIVNLVSFLASAVIAFCLCMVELEYAIGWRSLALMYRFENSKHARTQHYACCKHDKTHSPPDPEPQVTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKF6</accession>
    <name>A0A1C1CKF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cpdS</name>
        <name evidence="7" type="ORF">CLCR_04702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKF6"/>
    <dbReference type="STRING" id="86049.A0A1C1CKF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04702"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02997"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF116">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008448727" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="546" mass="59961" checksum="D1994794F0FA4EEA" modified="2016-11-02" version="1">MHFSTLLTASLAAGALAQSVSVSNPHKRAKKVVKRAPLQRGHLPLAKRQSPSYLTPQTEPFEVNGTGIPEVNFDIGESYAGTLSIDGNATNENQLFFWFFPSDNPAASDEITIWLNGGPGCSSLDGLLQEHGPFLWQSGTYAPQRNQFSFTNLTNMVYIDQPIGTGFSPAADGAPGKIRNETDVARQFAGFWKNFMTTFNMTGRKVYLTGESYAGMYIPYIADYFISQNNTDYYNVAGIQINDPSIGLDSVLIEVPAVTHLNNYANVFGLNQTFMAAINKRAHDCGFPQYMDNALTFPPKGKFKEPVNATNENCFIWEDIIAAAIYVNPCFNFYHLTDFCPFPNDELGFPSEGDGPNNYFNRSDVQQAIHAPPTSYAICGDPELFPKGDPSPPSSFTVLPRVIEHTNNVIVGSGLLDYLLLTNGTLMTLNNMTWNGKQGFQTKPSGQFFVPYNPTIGYAFYETFTQAQIPELPVGLVAGGGIMGTTHTERGLTWVTVDLAGHEIPQYVPGASYRQLELLLGRIKSLTQIDPHFTTQSGNYSGSTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKQ3</accession>
    <name>A0A1C1CKQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_04739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04739"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02830"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="32"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="516" mass="56393" checksum="9C7E4C133AE40469" modified="2016-11-02" version="1">MHVEDAPPKGIPAPAKLSLWRAVRKWPKVAGYCLALTTAILLWGYDMAMVGNLASLPAFQHDYGVLYEDEWIIESRWMSAWNAGSPIGMVLGALAGGFLLDHFGRRLSLGLGTLSSTVGVAVVWASQYSGSPQGIFLLGKVLMGLAIGVVVTATQTYMSELLPSTLRGPVIAFFPVFFLLGQLISAVIVFAAEDTEGPTSYRMCIISQWPFSAVPLLVALILPESPVYLVRKGKLEAAFKAQKRLDRASEDTQGRIEELQALILHEQESASTDETKYVDCFRGVDRRRTILVMFAAVMPQLIGLAILGDGPYFLQIAGMDSDDSLIFLISGIVGGLLGTIVSMWLLTFVGRRRLSIITLAPVIFLWLGMGIAGCFDSAVSPWYVGVTLNVVTFTIALGIWPASYVIGGEASSLRLRARSQGIGWATGGLANFVFSTVTPYIYNADSGNLRSRIGFVWTGLCLLTFAAVWYLIPEMLGRTPLELDLMFEQKLPARKFRQWEGQNIELMIVGTKAEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL22</accession>
    <name>A0A1C1CL22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1989 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL22"/>
    <dbReference type="STRING" id="86049.A0A1C1CL22"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05132"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02727"/>
    <dbReference type="eggNOG" id="ENOG502S1RH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527:SF0">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="75"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="246" mass="26572" checksum="23F55858EEE25194" modified="2016-11-02" version="1">MSSRTIPARTGAHVGLKKGQRLKLINPHGNQVIDFWAFVFPGSTPSDIPRSFIRSTQDASKETDATPFPFSSGVQYFSASRTRSILSKLIPSAETRDVLYTNKSVPLFTLLEDTTTGVHDTLFGCCDRFRYHNLGVDGYDHGSCAENMHVALREAAAAGLFAAGSISTEWTPDPLNVFMNVPITTPLDRQSGGGRIECVAPESRAGEYLVLRAELDCVAVMSACPNDVIPGVNGGVCTDAQYEVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL47</accession>
    <name>A0A1C1CL47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Palmitoyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">akr1</name>
        <name evidence="16" type="ORF">CLCR_04641</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase specific for casein kinase 1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="13"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL47"/>
    <dbReference type="STRING" id="86049.A0A1C1CL47"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04641"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02705"/>
    <dbReference type="eggNOG" id="KOG0509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="15">
        <location>
            <begin position="433"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT49230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="723" mass="80791" checksum="F3DD2A06ED6A92F7" modified="2016-11-02" version="1">MSSPTPNKLSHPPSSKANAASPKVTSEDVELAPVQNGQAEPNLPLEEDIMQCARIGALEHIQKMIQSGKHSANYRDEEGISPLHWAAINNQYAVCKYLVEQGADVNAKGGESNATAVMWASQRCHYYIVNLLLQNGADPLLTDGQGYNILHLATIDGNALLLILLLQQNIPVDIPDPQGHTSLMWAGYKGWPACVDLLLKWGASVNATDDNGYTPLHWALVKGSKACLDKLIEYGADRFAKTNEGKTPNICAEEMNTKRAYHRALADHGYDASGNIKTLPMNLHTIVRDRSKMAKFFFLYPFLIIIVGLYIISHLSIYIGVPIFLAVCLGMQYLAQRICMIGPLEFRQIHKTPYLAGVFAGTLFWVGASFITFILPLVFSTNPFTSVAFLTAYSATAYFYFLSMLEDPGWIPKLASRNQQRATIDELFSLWKFDEDNFCIQCMIRKPLRAKHCRRCNRCVAKHDHHCPWIHNCVGNNNIRHFYIYILSMAVGIVLYIRLVLSYLELLPPPSDDALSQCHILSPSLCTFVLRDPWTVALAFWATLQLVWVTMLIVVQTIQITKNQTTYENMKRHDKIHDHARPLLPTHNHPITQGASAAATSLNDSAAASTRLHPPPRRPDGFCTRWKKILGLDAFLVTASDASHGHMQSRNPFSRGIVGNCKDFWCDPAPVFGRRKNGEGFLGGEVVDYAHMYEVPLRLRTGRVRGGGDMRYESVAGEDVDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLF3</accession>
    <name>A0A1C1CLF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1776-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLF3"/>
    <dbReference type="STRING" id="86049.A0A1C1CLF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04754"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02607"/>
    <dbReference type="eggNOG" id="ENOG502QWSS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5308060at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013952">
        <property type="entry name" value="DUF1776_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08643">
        <property type="entry name" value="DUF1776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="58040" checksum="6D6D53B6CF22D8F9" modified="2016-11-02" version="1">MTSDDQQFLDLLASVPQDIAHYGSRVADYVDKHANAIANDIRDAIDRASWIPDSLRPPRASGTSGAFFVRPPPPPQGILQKTGAWVSRNRTAIAVVLAFAGTTIYLVHRRRRAHARKRRAKKLPNGAKKEIVVLACSTFHDALTRSLAVDLERRGYVVYVTVSSTEEDSLVQQEAKQDLRPLWIDLTSTVPNPAVDVHPNLEPIRDHITRGAGNMTLAGLIVFPGCSGYSEGPLALLPPSDIVDTINTRVVAPVLTVQQFLPLLANHSTDPKAPSSIVIAYPSIPNSLSPPRQVPECLVTSSLSALAHSLRREISAASANITVSELKLGNFDMGSVSTSPWARTTPTQSTLGPSGSSSSALTHSTYSQSQSQSGPQSHWHSSQRAAHQRKSLGQRSSFIRGSSAREFHNAVFDALAPPQTFRPFGYASLEFTSSRRADVVFVGSGARIYDLVGKVFPGGLVGLMMGWNRRRTAAPEEFYQSVYHDDARQVGRSTSASASGSAVGTAAAAAAAASGSATGGQSTSASAWGFHSLGSDSGIWEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLG1</accession>
    <name>A0A1C1CLG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05190"/>
    <dbReference type="OrthoDB" id="4147536at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="192" mass="21834" checksum="2C1896E2AA4514D9" modified="2016-11-02" version="1">MTGWPSSTHVAVLEDIFKSKTDVFSAGSSTDLQYFSSVVYCEVQHAVMGLWKTSLDLCCRGWVKRQFVTLWKQVSPNVLFSRAQTQRNLDPWLQGSSHPGILYLIVQEVLNVIALKRSRSQKPPEYLLDVALSHFKDNTHRGKTYQSVRASRHRGYSPLYRWFGHDVLGDEETGNGRCQPVCGLLASGDRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLG5</accession>
    <name>A0A1C1CLG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_04613</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLG5"/>
    <dbReference type="STRING" id="86049.A0A1C1CLG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04613"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02614"/>
    <dbReference type="eggNOG" id="ENOG502RJ72">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5414787at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT49327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="743" mass="83638" checksum="811682641D35526C" modified="2016-11-02" version="1">MSEPDSNSPASAPTKRPRPVISCLECRRKKLKCSRTHPCQQCVKIGKPSRCEYQAGQEPEPNVDYSASYNAPNKRPRLLLPPDYNGDEASLDRIDTRRQGPVTAKSGVLEDLQERVARLESALLAQNAQTNRESASYSHSTGPPDSRSSADGTRHLGRSIHISSKIRQLRADLTELHSSVESNHREQRSQATSSVSPNTRHTLRSPPFEICQKLAVLYFDNMEHCFRILLWSEFRDQLNLLFSEGETACRFGFIPQLVGALAIAVLLGTHQECEAAAAYRTISATEAIHFMEEFLRGLHHNDRYRLPALQVKMLVLICRWLNLEPFDNLFRLNGELLRDALVMKMDQDPTSLDNVSIFEGELRRRNWMTIIEVDLMLSILCQLPCLVPPYTSQPPRNVNDDEIFECMSALPASRPTTEWTDGLCQYLLAQTFPRRVSACAQLDKLSRVTAEDILPHIRYLEQVLQELPAPLRFNYLGDEASKTPARLMARMELDISIRRPLMHLYSRGVLSPDLEDVPRDIRAGYLQSCLMIANYQDLFDPQYSELDVPRPHGYWDFFYSCYRQELGQATLGLCVEIKNLSSTIHANVNGSTNPASSSSSSSSSSSSSDIPANTIVKASPYTRESLINAVKDTLEPMRRRLPHRASKVKDIVYYETILTSLLPETAGQAKEVVMTERLHSLVRECRVELERAAVTNASASAHDAGHEIPDGNISSFDPLWEGFPKIDIFEPLDFAPASADPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLJ4</accession>
    <name>A0A1C1CLJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_04656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04656"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03306"/>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT49388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="617" mass="70001" checksum="209D9BDD339C29ED" modified="2016-11-02" version="1">MSPEPIPDRNNRPKRNKTELACDVCRKRKSRCDGRRPACSHCENMGLACVYRPPLTGLETDTSVLARISHLETRVQALDQGRLDSTVATPASENLTVKSWPKVPGFHHAAAHKMFHYWSQLRVNLKLNLAPLTFLRQVDDSDNALFAPDVNMHVSPEIPMSVVARGIESMFENLHRLPFVLRHLFTQGGLTSEACLAVFRRYLGTSPGHDLTLAFNTQCAEELLLQTVALKHLAGVRADYNLNQKADLSFRHVLQHTLVMQAQQSPQALPFKFLFVIILLYLYGRPFHALGLLQGFEPLIHNASPNTQEDLDILSEIDGTPSQRLPNVAVTLAHDIVTTPPHLFENDSTAPTTDDYQPQELQAHLRLRGYMNGILEHFYVVNRAYCRPEDVAGILPNIARRLDVWYWTLPVEMRFPRYPPAFILASSTMSDLMDELKFRYYAAVFLVNRPILYHVLYAEYENAVVSSSTDSSRLDPWVYESCHNCVQMAIMIVLLHSNRQQRNPHECFENWCNLQHLIAAYAIILQVQSSAHMSILLQQGCEADQLLDSAEAVLERGMNRPANIRETLVMLRNVRQNFQKHTPRTPLIGNTFATSPVYSVASHQSHHSHDTKAPTMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMB4</accession>
    <name>A0A1C1CMB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_07140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMB4"/>
    <dbReference type="STRING" id="86049.A0A1C1CMB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07140"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09895"/>
    <dbReference type="eggNOG" id="ENOG502S1A6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="50"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT49650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="372" mass="40795" checksum="2BD9C4010553D1EB" modified="2016-11-02" version="1">MSRPDQKFAVPGGAVARLRIIDSTTKIKGLPLDYLMTPAMPGMDVLPEAPTWSFLVESDTGRKALFDLGVPPNWREFSPVVATPLQTRGWGEPSGEKHVADILVEEGIDLSSINSIVWSHWHYDHIGDPSTFPPSTELIVGPGFQEAFCPGWPARQDSPVRESDFAGRPLREITFSEPDALQIGPFPAYDLFGDGSFYLLDTPGHAIGHLAGLVRTTPDTFVMMGGDLCHHGGELRPSEMMPLPAQVQLPSLSLNPNQHPGCACICPGSAFQHIQETRGRKADEPFFDPAIGYDIPETIRTIKKVQGADAGENIFFIYAHDTSIRGVVDLFPATANEWKAKGWREKAFWRFLEDFGGALSSDLSLEKVEAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN05</accession>
    <name>A0A1C1CN05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gst3</name>
        <name evidence="7" type="ORF">CLCR_07441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN05"/>
    <dbReference type="STRING" id="86049.A0A1C1CN05"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07441"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08803"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03189">
        <property type="entry name" value="GST_C_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000156">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="121"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT49886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="266" mass="29620" checksum="E9E14546DDE1D906" modified="2016-11-02" version="1">MASSGNSEGAPATGEPKIVLHWLEVSRSQRILWLFEELGVPYELKTYKRTKERLAPPELKEVHPLGKSPVVTIEIPGSATPIVLVESAAIVEYLCDHYDGQGKALVPTRYKPGKDGQIGGETESWLRYRMLMHYAEGSIMPFMVLSLIVGSIRNAPVPFFIKPITNSVAGKIESGYLQRNFKSHYDFLESQLSTSPDGGDYFCGKDLTAADIMLSFPLEAGQSRSGFTASQYPKVWAYIDRIHQRDAYKRAVAKIIEVEGDFKTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN50</accession>
    <name>A0A1C1CN50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN50"/>
    <dbReference type="STRING" id="86049.A0A1C1CN50"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06726"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08851"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="505" mass="53402" checksum="782440965F87DEA9" modified="2016-11-02" version="1">MATSGQSQRSVKVAEPDEAAHSLDHPSTINKSTSTGPYQDATTSPQNRDSQAAANLAAAKPIVLFAAVFLSTFLMALNGSIISTYTYITFASIFSVGALVCATAPSSTALIVGRAIQGIGGAGVINGAFAVIGAAASPQNRPRECSLGSQSAFHRFYINLPPGGLVVCTLLSLTIPEQIKKQPVRGNLTNLVTKELDLVGFTLFAPACIMFLLAMIWGGEDYRWDSSVIIGLFCGAFVTFITFATWEYFRGDKAMIPPSIARKPLVMFGGFTSFLQVGALLLLSYYLPLWFQVVKDDSPLMSGVMVLPTAISQAIAGITAGKLVQVIGYYTPWALLGCIWTSVGSGLMTTFTGSSGAGAWIGYQILAGAGRGTVVQMPITAIQNLLPPKEVSIASSQIFFWQYLGGATFLAIGETIFTNTLRSSLKTYAPGVNPQDVIDVGALAVRSSAPKADLENVLRAYNHAIVTTFYLAVGASSAAFLTSFGMGFQKLPKRQAPKKSKGSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CND3</accession>
    <name>A0A1C1CND3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_07706</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CND3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07706"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08946"/>
    <dbReference type="eggNOG" id="ENOG502SRJN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5290969at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF3">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="158" mass="17245" checksum="BDAC03EBC2F8D8C7" modified="2016-11-02" version="1">MEARCQCGQIRFVTPLAAPLALYICHCTECRHQSSSTYGMTAIFPYFDIRQYAPTADTVGMYSRANSTGRTDGYFCTKCGSRLVHVSMSAQDGQSGDGRGDAFKPAAMLSVKAGCLEGLSKEMMRTAIHIWTKSAVVYIPEGVEQYEEEPPGGSFAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNG8</accession>
    <name>A0A1C1CNG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CLCR_07162</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNG8"/>
    <dbReference type="STRING" id="86049.A0A1C1CNG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07162"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08973"/>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2505961at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF100">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN YNG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="17">
        <location>
            <begin position="384"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="189"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT50056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="451" mass="49035" checksum="D24C425860D5D3AE" modified="2016-11-02" version="1">MASNEDCASVLEQFIHDAANLPAEITHMMEEIQAKDKDLQKHLSVVNQKDANIQKHLKTNGVLAPHPKENEYADLVKKNYDLCLALQDQKIALSEKACMLLERQVKKLDVKIRELQNDGQLQDGPPLPSVFNRKTEAQKPFLELPTNIPLQNASVSALNANAHRANAQTAATIQQTQARPVPQINTVTAPAQRSSAPATPASAVQQQRQREREHSLGAENKRRKLGNPLAGANLPAQPSGLRQSSLGPGTPKAGTPTGTSRAGSIPRTTGSQQAAAPPKKSGLPKKVISHQQVNKLKQKASNKGRLSAGRKKGQSPSVRGGRGGTAASEDADSALSSADASETDASQSRRGRGNKKHQQPVAEGADAEAGEDDEMDDDDGEDDKVYCFCHQRSYGEMVACENEDCPFQWFHTGCLNMKKVPDEDEDWYCPNCREKPAIIEKVMRKMQTGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNN0</accession>
    <name>A0A1C1CNN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07084"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09018"/>
    <dbReference type="eggNOG" id="ENOG502SFF5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4892437at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="400" mass="44350" checksum="CE38F0D6109DF63A" modified="2016-11-02" version="1">MPRITPLRILLLIPVFYAVLVLLWAALPSPEVPWGTDIVGKAAEHLWRGGTITRVYEVDDFFPYADSSPYVQTARRSQRLSFALDFAYNASSRRLAIGGYYDTQVWNVSMLLEVASYHDDNVYLTESFGVDVKTGDHDGINLPWFTPADATLLFWEIHEEVVPVPLRLRAHGDRNIQVLPDSEVWTLRELQHAIWPSGDVAPNSSPSSTFMARRAILRILLPSWSLVADVLMPRVGRLMVVLATAVSLAFWVFVVYAAVVLACWKASGMTDFWPWARTFWMTRRVVSYLGAKISPARDPAEGKVVVDESEGAETTDEVARTGPTPLTSPWAFFTSSSPLDDLFVTFEATKPLVQPLGRTGLRRRRTGDLEGQGESTASTPSASKEPNGEIATGESPAPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPG9</accession>
    <name>A0A1C1CPG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF500 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPG9"/>
    <dbReference type="STRING" id="86049.A0A1C1CPG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06947"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05625"/>
    <dbReference type="eggNOG" id="KOG1843">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF8">
        <property type="entry name" value="DUF500 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="183"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="570" mass="61978" checksum="299CFAD43CBFC354" modified="2016-11-02" version="1">MAQPTEGPALQSTTTTTSTKTSSGTSTLWDKTKSGSSTVYNKALLPGFNKAYKVVDKLGAPVNRLSNKVGSEAFWPTTMDKESEKAARILRGFCKDGFYDQIEEKELKKVETRNATAVGVPQGKQRVMKKIPASVIKNAVGLAIFTTMRTGWLFGGSGGAGVLVGRHPETREWSAPSGIQTQNISFGFLAGVDIYDTVLVINTYEALGAFTKWRTTLGTEVGVAAGPVGIGGALDTELTKRQAPIWSYVKSRGLYAGVALEGNLVIERTDENARFYGEQVSVTDILNGKLRHPPAEQYQVLIDTLRAAQGEDVDDSLLPDAPAPSDMEIIQQGGPTFGIPSEDDPDPYGVKALEAEGLNIREAGTHQRPPAETFEFRPSPTSPVYTHFSRRSVDGSIRSRTWRDSTHSLASVTRGTQTDDDDPKSQENSPHRDSLRALEGHHSRKHSQLVDEPHHERDESFSDVDSDVEVSTAVPVMARAKVVEVPRRIPPALPPRNPGRVASPNLETQPPIDGFDKIDLNGDAEQRHEGGHVITPTSTREANDSTFHSIPVTPSEEDKDKPNDIPGSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ57</accession>
    <name>A0A1C1CQ57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName evidence="10">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">UTP25</name>
        <name evidence="14" type="ORF">CLCR_06720</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
            <location evidence="2 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UTP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ57"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ57"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06720"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05377"/>
    <dbReference type="eggNOG" id="KOG2340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002356">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="13">
        <location>
            <begin position="259"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="12">
        <location>
            <begin position="544"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT50636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="738" mass="82989" checksum="DD0B08E8D9C58F58" modified="2016-11-02" version="1">MAGFRHRRGGKPAGRGRGGKRGPVLQQQDQFKASRLRETADEETQIGAESEEDPLEVVDQLESDQDEDVQSASEDEPLSSDSYGLLLQSLNAAMETSEPPRKRRRFIESDRTGGSVEGEDTKSQQPGQDQTVQAEEQLLELEEDVEADEEAAQVAEADSDDEEVLLRDPFELHYAARTEQDLKSAVGQVDDKQWETSSSVLDPDIRRTAICRRGTPAEVAELRSTKDAYLKRRLIDGGTKVLSRLAAEERNVAESIFNYADVLNGCRNLKNATRLRDLSCLHALNHVFKTRDRVLKNNAKLAAQSAEALDLRDQGFTRPKVLVIVPTKQACVRAVDSITKISEPDQQENKARFLETYSREDEDEWHDKPDDFRALFGGNHEEDFRIGLKFTRKTIKFFSGFYNSDIIIGSPLGLMRTITTGGGKDKKKTHDADFLSSIEIVIVDHANALQMQNWQHVDYVFSQLNLLPKDSHGCDFSRVRHWYLDGQAKYLRQTIILADYLTPEINALASTHLHNIAGRVKYIPTYPGAMLSVSSLALPFPFTPPIPQTFLRIPSPNPLSDPDARFKFFTTTILAPILRDSRHQRGILLFVPTYADFARLRNHLSTSSDAASLSFGSLSEYTPVKEVLRARSHFLSGRHALLLYSERSHHHFRYRIKGVRKILWYGLPENPLFWAEIISLLGLGSAKDGDAGRGKGSTKGVIRALFSKWDALKLERIVGAERVGRLINDRGGDTFEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ85</accession>
    <name>A0A1C1CQ85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07788"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05339"/>
    <dbReference type="OrthoDB" id="4145588at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="105" mass="12143" checksum="3EC96EE787D30B08" modified="2016-11-02" version="1">MSRITRINPNLKRSQTEDWFPKSPDGAYTGEKVPFRNRRRGPSTTTIVLLLLLVLAAGVLVWNHEQAVDLAAENYQKYTGQDLKKTDLYKVIEKAQKIKWKRSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ86</accession>
    <name>A0A1C1CQ86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Low temperature viability protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ86"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ86"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07088"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05344"/>
    <dbReference type="eggNOG" id="KOG2637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5852896at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04180">
        <property type="entry name" value="LTV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="478" mass="52632" checksum="25C23D15382C76EF" modified="2016-11-02" version="1">MPRGRWIDKKSAQTFHLLYRPQTDEALHDETAGERALYQISGPGSSSQHKPELKEGLHLKDLEDDLDFEDMRENEGEAAEYGIYFDDTKYDYMQHLRDIGDGGIEAQFVEAVPVKVQGSGKGKAKTMKLEDALRELSVDDGQSVAGSEMFSTFSTATRPRTYQNQQDVPDEIAGFQPDMDPRLREVLEALDDDAYVDEKDEEDIFGALAQEGRNGELDLDEFTATYDEDDEGWESDVTEKASEQPLQLKLPAPIQTLEGADQASELPAPDAEAAVAADGDWLRDFAKFKRDNARKAPPKAAESIMAASAIQDKAPSLYTLNGTPLRQKKRKGALTNPSAYSMTSSSLARTAGQQLLDARFDQVEKMYSLDEGEEFDDADGGMSLASGMTGMTGASKMSKMSQLSTTSFADEGAVREDFDSMMDGFLGDWNKANPGGGKRRGAKAKRGKNGNEKFGLQQLDEVRAELGPARIYQRTTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR38</accession>
    <name>A0A1C1CR38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ams1</name>
        <name evidence="10" type="ORF">CLCR_07938</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades free oligosaccharides in the vacuole.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR38"/>
    <dbReference type="STRING" id="86049.A0A1C1CR38"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07938"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09598"/>
    <dbReference type="eggNOG" id="KOG4342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10812">
        <property type="entry name" value="GH38N_AMII_ScAms1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="9">
        <location>
            <begin position="555"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT50955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1086" mass="123154" checksum="E99100572861EBC7" modified="2016-11-02" version="1">MGGETSSRATSSYPKLVQRPVGKQIESIYTDRLRQFTSGGQYEHQNLIGKLYHNRCDDEQHVKLSVYSPPNLTRPTFEDATSHTFRPTRRGESFGPAWATHWFRVQLTVPQHMRDGEHLEFHWDAGNEGMVWTHDGKPLQGLTGGDRTEWILPNSWRDGKEHTFYIEMACNGMFGNAPGGDSIQPPDPNKHYTLWKAQIVDVNLAARQLYIDFWIIGDAAREFPGDSWEKHEALQVCNQIMDAFIAANGSQASIEQGRKIALKYIGKNVDSAKIYESGEKPLVFGIGHCHIDTCWLWPWAETKRKVARSWSNQCDLMDRYPEHRFAVSQAQQYKWLKAYYPYVFDRVKAKVKEGRFHPIGGSWVEHDTNMPSGESLVRQFLYGQRFFESNFGERCQTFWLPDTFGYSGQLPQICRLAGMTRFFTQKLSWNNINNFPHTTFNWVSLDGSQVICHMAPSETYTADAHFGDVRRSVTQHKSLDQDNTSLLVFGKGDGGGGPTWEMLEKLRRCRGISDTVGLLPRVHMGNSVDDFYANLEKKMAAGTELVTWYGELYFELHRGTYTTQANNKLNNRKQEVMLHDIEYLATLASLKSKSYKYPKKEIDEMWENVLLCQFHDCLPGSSIEMCYDDSDELYAHNAKLGEKVKEEALTVLGLSRHLKANAELAAVNTAPWQRSELVKIPQANAKSQQQKYTYVSGGPGICKTHAASAIRSTASVEEVKKGVFVMKNSNFKVEVEAGVITSLIDLRANREVIAKGAKANQLVIFDDKPLYWQAWDVEVFHLDSRKELKSEASEIVEDGPYRVSVATKTQVSKDSWVKTTLSLDATDSESQAGYLLVEAEVEWRETMKFLKVEFPVDVTNTEASYETQYGIIRRPTHYNTSWDMAKFEVCCHKFADLSEAEYGVSILNDSKYGFATCGNLMRLSLLRAPKAPDAHADMGRHHIKWAIMPHQGALSSDTVRAAYNFNHPLTLVSLVDDKPVRELLNAVSVTGAKSLVLDCVKRGEDDEDVSRGELTRRKGQSVIVRIYESLGGKSRGMIETTLPVKKVYETNVLEDDGEEVEMSGKNKISIAIELRAFEVKTFRLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRI9</accession>
    <name>A0A1C1CRI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_08882</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRI9"/>
    <dbReference type="STRING" id="86049.A0A1C1CRI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08882"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09739"/>
    <dbReference type="eggNOG" id="ENOG502RXUQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5957391at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000059">
        <property type="entry name" value="Histidinol-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="5"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT51109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="317" mass="35995" checksum="541EB82E7150FB4F" modified="2016-11-02" version="1">MPHSHHSHSGQFCPGHARDSLESVIQHAISQQMTVFGLTEHMPRHDLDRYPEEGDTSLEQQLANEDAYVKEAHRLRAKYESQIQIPIGFEGEWIRPESQELIEASIQKHPYDFFIGSVHHVHTVPIDYDHDMYRDARSKAGGTDERLFEDYFDAQYEMLKAVKPPVVGHFDLIRLKSDDPDGCLESMHGVWSRILRNLDFISGYGGVLEVNSSAVRKGMHEPYPKGEICQAALARNIRFCLSDDSHGIDQVAHSYGRVLQFLDKVGIQSLSFIRHGESTGTAERKGSTDERFPSLHVECVDVKDLNVNKFQQVTKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRK2</accession>
    <name>A0A1C1CRK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09176"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06934"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="183" mass="20630" checksum="70C7CE3AA17AAB96" modified="2016-11-02" version="1">MPSSQYRHETTGSGSRRGQSVREASGRSGEVRVISYRDAEGVQRVVRLEYRPDVILEERRPRNATAFEEPPQSLSGAYVRRAAAREPASQGRPQYASSSRQPGRSAGRQESPFGVDRVHDASRSSGGATAAARQANVRPVYEERRPRYIDDARRYGHQPSYQPSGREQHPDHRPARRQEKEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRK5</accession>
    <name>A0A1C1CRK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VPS9 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRK5"/>
    <dbReference type="STRING" id="86049.A0A1C1CRK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08065"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06946"/>
    <dbReference type="eggNOG" id="KOG2319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF97">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="234"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="781" mass="83567" checksum="903BCF06DDEB1A60" modified="2016-11-02" version="1">MSRNVSTGSLRARPSALSTKSFTRYEPSLTSPTSATGRSRASTIQSVTDVKSPKKVDASPEDIFDKSITEENEPPSPDLGRSNSLPERFDELPIELASLCDRFVESLSAKVYNEPPAIDQLAELFQEFYARASGAVSIHIATLRSRLNRGTSPTPSKAGSRTRAAPSKSSPDSLGSGAGRGGAQQMLTASEVTERRKQRKLLEYKRIVLEEAVEKRVCEKVYDKIWRHKSTLDEVRDEKLRSKTAALALVGIGLKDLGIELSEDSGTSAEDVQASLAPARESLAKMNDERYPLGKLQHLTTAHKAVVDTLSSIHSSSSSADEILPTLIYTLITSPIEGINVISNLQFIQRFRAAPRIDGEAAYCLTNLEAAITFLEDVDLASLREDEKPEGPTKTQAQSEGDQDPEKLEAFPPLPGTAPAPSTPTTATSTLNATGTAELSPAASVIKDLPEKSTKTPSTRHQRTLSDLLQPITNANEAVRSTAEEGFKNISNTLDNSLKFFLGKLKERGSEGPNTEVVVPKTLDEARQLVSRPLTPDEDDHALSESSSMHDGQTSPMPSNLTKTEEKLLGLLGGRKAAIRERSVDSIKSNASAGGKRAGFLAATTNSPPNGPSVPGNAAAAPAASSSNPLETVKNFGNSLNPMGSLGSAFGSAFGRFGARPSASPPSVPPTSATPTIVVDKDAKTTMAPTVEEAKPPKTTNEVPLKTPNKTELAAIRAAPPIPRFLLLGDASDLRLGEVQDLLDDYQRLARVLGRLVQRAQNEGEDEAELEDQEDLDVTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSA5</accession>
    <name>A0A1C1CSA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09128"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06709"/>
    <dbReference type="OrthoDB" id="10411590at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="206" mass="23528" checksum="EF3136AA99D40C23" modified="2016-11-02" version="1">MRDTQGGRSDDPERTAQEHQTHVADKAADETEGHHGQHFAGLSELTESVDILFPLTGEALILRRKLRALIKKFRTTMRLARPLVYAPFVAEAVRMSMLYETFQTLMPESEALMRNLIEYLQKATRGMQTYLGIRTSDLQDLILKDIDGTILEATDIMDVFYRVHEKLEADIDVYEDLVADVQSWAGFRLEQIRTRARDAARLAMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSZ4</accession>
    <name>A0A1C1CSZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09174"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06492"/>
    <dbReference type="eggNOG" id="ENOG502SWHW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5377039at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="184" mass="19376" checksum="B059778630999DBD" modified="2016-11-02" version="1">MDDADETMTTSTSSTPSQLQDTTVADDEVFDRDIQPSHPHPRPGDSNRAVTPANDHLNAAAPGELSPPRIQPTQAEYTAALLPDPAPTSAAMANGTAVRSSARLANANANTSTQPKSGGAGDTATFPALAANEKDIANQPGGGWKNKKAQEDMHRAWDNIVDRDVSLKEYGDVMMQGKAQRAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT04</accession>
    <name>A0A1C1CT04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat protein nuc-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_07937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT04"/>
    <dbReference type="STRING" id="86049.A0A1C1CT04"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07937"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06482"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14483">
        <property type="entry name" value="SPX_PHO81_NUC-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="4">
        <location>
            <begin position="8"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="427"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="462"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="5">
        <location>
            <begin position="707"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT51616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1017" mass="113726" checksum="2C5B6C2308198061" modified="2016-11-02" version="1">MSEFNETRKFGKQIQRQQLDLPEYAASFLNYKALKKLIKQLSATPTITAQSGSTATDTQAALRANKEVFFFRLEREIEKVNGFYLQKEEEFSLRLKTLQDKKRVIQARLAASSRLSASFATLVEGFQQFDNDLNKLQQFVGVNETAISKILKKWDKTSKSRTKEIYLQRAVEIQPCFNRDVLRELADKATTARLDLEAWAEGENIQYEVPRPQDRTIGQRVGTEESDIDLQILQASAAGNVAALREWFSRLGTSPDARDRFTRIFLASISEAPDESLNVFFHSGLIDIHAEDDINERNCLHEATIYGKESVLNYALENGVDLTRVDAYGRVPLHYACLRGRIGMVATLLAAGPSTIDLKDHDNFTPLIHSIVRHRIDCVRLLLANNARIDPQSDNDHIPLNLACQHESIEVAGLLLERNARLLADAEGLFPQHLVARSSQKPDLLLLLRQHGADLNQRDKLYQWTPLFHAASEGKVECLRALLENGADPEALDEKGLTAMYYATWEGHLECMDLLWARTSQHRAERRYSTRLGVVAPPHSQMLAMEITPEEPTAMDADGIPDLSLPPPIMPLRRYGHSFLDTKTFIAINFDRAAKAIQFFNEARYPAARLTISSKTSDLIPRNLMLPIQEDSRSVYYQIENLSNFSLDFEIFPTFGSKVIAKTVALPDVFQAIESSAGSCCLPLFDPRLRAVGQIQFNFQVIKPYPGKTLEITQFPFYWRQTSALDDQGGSMTGSSLSGDYLKITVQLTRDRVPVIYPSYFVPHHNLEVSLCQLTYDTLANLGMSGNLLNDGAPALESVNIIDWKERLSKSIFTLRGVLAAVPVQLNLNLHILYPSNYEDLNLGVYSNTDINTFADVILTEVFNHARALRTQSPDLTRSVVFSSFNPNICTALNWKQPNYPVLLCNDLGRLQSALQPSSNTLEAGLARGTSIKETARLSQMNNFMGLTCSARILQMVPALTETIKQAGLVLVSDASAEDNTAHGLEADGAIFAMKPDGVSGVMKANGILRFNETVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTB3</accession>
    <name>A0A1C1CTB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ribosomal protein subunit s18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_08983</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTB3"/>
    <dbReference type="STRING" id="86049.A0A1C1CTB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08983"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06363"/>
    <dbReference type="eggNOG" id="ENOG502S752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="271" mass="29621" checksum="254B2051D7C4D3F5" modified="2016-11-02" version="1">MAHPKSLLLSSMCRSCRQSQLARTQSHRTLSTTSTSQEPERPSRGGLAQRFGIKYNDDRTPRTPVDPLAAFSEVLQPPTATPTNNAMRNSMKNDLRTISLFDGEDAPSASSGTSPATRAPNPYLDEPYHLNVYAHRHNTHITFTEPSRNPILSLSCGNLGLRNAQKASYDASFQLAAYTFRKMAEKQWKIGGANSKSPWLTLSSIKKPAYSGSAGAGIEVILRGYGPGREAFQKALLGTEGRMIKPLISKVTDGTRLKFGGTRSPQVRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTS4</accession>
    <name>A0A1C1CTS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_08578</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTS4"/>
    <dbReference type="STRING" id="86049.A0A1C1CTS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08578"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06236"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651048" description="Peptidase A1 domain-containing protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="11">
        <location>
            <begin position="63"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="327"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT51889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="423" mass="45969" checksum="CB742F25A6CF21FE" modified="2016-11-02" version="1">MWPALLLSTLLLGVASALPSPQVQDPAKSFITLPFTRKLSHSPARLKRQAFDSELLPLTVASYYIEVTVGTPPQPLSLVLDTGSSDIWAYSPAARASCPDCTDIYLDDPTDSSTARERPDLGLFNITYGTPNSGVLGYYYTDVIRTGGVGVNAFLGVTTDANEGAPPGGIMGIGLSENVASLYQSGIKYEGYIDTLYEQGLIGSRAYSVFFNEADLCPLTTPPASTDKDEGVIIFGGYDNTKWIDELTPFPIVYPSPRGAAELNIEGPAIEITVGDDTYDLPTQSYTVLLDTGSTYTYLPRRQFNTLATALDAELAYEDYDLYVVSCDYKTVDGGLDYTFDGPSGRVTISVPWEQVVIENDALPDDVCFLGFIPDPDNEGFYVFGETFLRSAYLLYNYDDLTISLAQASYDTSCDDCAEALVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUB8</accession>
    <name>A0A1C1CUB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II subunit beta</fullName>
            <shortName evidence="4">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_08501</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUB8"/>
    <dbReference type="STRING" id="86049.A0A1C1CUB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08501"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06055"/>
    <dbReference type="eggNOG" id="KOG3092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2275560at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT52084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="488" mass="52855" checksum="4F22DEA5A9C7F50D" modified="2016-11-02" version="1">MSQSSSQSPDSWIGTFCNLVGHEYFAEVSEDFIEDDFNLTGLQAQVPMYKDALEMILDVEPSETNSSALSEEEEEEEEEEDDGILGDELDEPPAAPNGGSRRQSGVSANGRRHGRTSSDTSVIESSAELLYGLIHARYITSRPGINQMMEKYELSHFGYCPRVYCGGAKVLPVGLTDTPGQQTVKLFCPSCLDVYTPPNSRFQAVDGAFFGTTFPCLFFMSFPELDVAPVKKRGPRDPNNPGNDDLEGTLSPNEAASSRGIITASRSSSLTLPQPPAIPGVTAAKDEKVPGSSSAISALPPQPATLNGVATHNYAPGLGKGKIYEPKIYGFKVSERAKSGPRMRWMRSKPVDINELDEARLWHERYGGNVDGDPDEESRHLAGDLEDNDDDDDVDDEDEEEEDDGAVADQDGDAIMATQSQQPGPSTQKGKSKREPDADGDALMASQSQGGSRGKSRRKSGARVGQGIDDVSAQHQHQHQQHGDGNWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUQ0</accession>
    <name>A0A1C1CUQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09323"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="103" mass="11705" checksum="8AB565D2B580DED8" modified="2016-11-02" version="1">MIWTAAFEDLDQSKDETWKQLQGWEGLCDWFDGRGLEFDTLGDVRFANEFRTSSSINAGLMAIIPSIEVLLDSQTPFYGTPDSGASRDACRAARAWRAKFYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUS6</accession>
    <name>A0A1C1CUS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Maltose permease MAL31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MAL31</name>
        <name evidence="10" type="ORF">CLCR_08295</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUS6"/>
    <dbReference type="STRING" id="86049.A0A1C1CUS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08295"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05919"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="52"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT52243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="521" mass="57698" checksum="0DD66C96B3D09B57" modified="2016-11-02" version="1">MDKDIETRKDPAALIATASIDDINAEARAAADREHKLSFWEAVKLYPTAVGWSLFFSIGVIMCAFDPQLLGQLYATSAFQRDFGYLYNGSYIVSAPWQTGLSMGSPIGQVVGAFCAGYPMEWFGRKKTFGACIILTTGFVFIQFFARSLPVLLAGELLGGLVLGSYAVIAPAYASEVCPLALRGVLTSCTNICFVTGQLIANGVIAGTHKIDSHWAYSAPFAVQWLWPLVIMIGLPFAPESPWWLQRQGRIEDAEKSLKRLASRGVDVRPTLAMIIETDRLEREIESGSTYLDCFKKINLRRTEIAVGVYTIQVLSGIYLVGYATYFFTLAGLPDDQAFNMGVGFLALGFLGTCFSWVLLIYFGRRTIYNTGLALLAALQFIIAILDCAPHYDNRPGIKWAESVLMLIWNFIYDLSIGPVCFVLLCEVSATRVRGKTIAIATAVQATAGIVMTVAIPYMINPDQANMRGKLGFFFGGLAALCLLWSYFRVPELKGRTYQEVDIMFERNVKTRDFKHYVVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUU0</accession>
    <name>A0A1C1CUU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sod2</name>
        <name evidence="8" type="ORF">CLCR_08519</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUU0"/>
    <dbReference type="STRING" id="86049.A0A1C1CUU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08519"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05908"/>
    <dbReference type="eggNOG" id="KOG4505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF2">
        <property type="entry name" value="CATION_H+ EXCHANGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="7">
        <location>
            <begin position="24"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="479" mass="52623" checksum="C7E2B99B0AEBD740" modified="2016-11-02" version="1">MAWPQIEPSTPHLTYLYLAFFLILYALFSELIRNRAHLSEPPLATLAGVFAGPRGARILDPVSKWGWEDNITHELTRIITGVQCFAVGIVLPAKYPKHHQESIALLLGPTMTAGWIISALIVRFVLKTTWVTALIVGACLTPTDPVLSASVIAEAKFSQRVPQRIRRLLSAESGSNDGTAFPFLYAALYAAIAKSTGQGVRMFITDVLLWQCLTGIVIGIIIGLAARRTLRFSEERGYVQESTLFVFYFLLAVLCVGVGSTLGLDDFLVCFSAGTAFCWDGWFSSRTARMKLPSILDLMLNSTMFVYFGSIIPWQMYRDNLAPGRILLCVVLILLLRRLPAMLALKRFIPDVKTYGEAIFAGHFGPIGVGALFLSIEARARLETGTSEPLPHPGKHSNHRDAIATVWPVVCGVVFSSIMVHGFSPLVMSIASHFMRHPKERSNLVGGDVDGLGGMLHEDEDDNEEEIEGGYTDDVDGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUW7</accession>
    <name>A0A1C1CUW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_08723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUW7"/>
    <dbReference type="STRING" id="86049.A0A1C1CUW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08723"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05876"/>
    <dbReference type="eggNOG" id="ENOG502SI4Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="384" mass="42893" checksum="CBBE31DE1BA24FE9" modified="2016-11-02" version="1">MRRKQKPLVHLVFFATVLLAILFLNHSRSPDKAFAWTTIRYKSTATSFPPTRGICPGLSPEKPALVVARVQADGAPEWLSTLSDRYHLCVYTADAAEDLGSMNLQVPANRGHEAMAFLTFIIDNYDSIPEAGAVFVHGSRFSWHNDSPDYDNMALLRNLNISAALAPWGYHNLRCDWSASTCDLSSAPPQGSLETSFRAVLQPYDPRVVSDSALPRALAVLFRGDESEAAKTGGQVFLGRGDAVRSQCCAQFVVARESIRRHTRDEYFALRQWLLDGISHHDLHQRTLNKNAAPRDDRVAGRILSYLWHILFIQQRGSAKQGRDASTIDLQQLNRRACPRADECYCRLYGRCNLPGCNSPGRCAGQYRIPPDFKLPADWPASHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV03</accession>
    <name>A0A1C1CV03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DPS1</name>
        <name evidence="16" type="ORF">CLCR_08333</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV03"/>
    <dbReference type="STRING" id="86049.A0A1C1CV03"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08333"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05840"/>
    <dbReference type="eggNOG" id="KOG0556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="240"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT52329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="554" mass="61447" checksum="FCBDFC9C7A009A70" modified="2016-11-02" version="1">MENKEASLPTHAKDNPNVSADGAPSKNALKKAQKEAEKAAKKAAAKAKEAEQKATQQAQAAEDTATGNYGPVPDDAVEITHLKKLGDDHVDKEITIIVRIHNSRSQSAKLAFLMLRQQGKTIQAVVAATGDHVSKQMVKWAVGVNINSFVRVTGLVKKPDSPVASASISNLELHVTKIYLISSAAEQLPMQVKDAERPPPAQEKEGEAAVDAEGIPIVTLKTRLDNRVIDLQTECNQAIFTISSGVESLFEEYMRKSGSRKFNTPKLLGAATEGGSGVFEVNNYFGKSGFLAQSPQLHKQMLIAGDCESVFEIGPVFRAENSNTHRHMTEFTGLDFEMVFNHHYHEVLDFAEKLIVFIISELNSRYKDEIAVVQKFFPRAGDFHLKDGKALRLKYFDGIKLLRDAGVDTTEQDNYVTDLTTAQEKKLGQIIREKYDTDFYVLDEFPMVVRPFYTKPHPTDPKLSNSYDFFMRGEEIMSGAQRINDAAELEASMRAKGVDPNAEGFQDYVNAFRQGCRPHAGGGLGLNRIVMFFLGLDNVRQATPFPRDPQRLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV08</accession>
    <name>A0A1C1CV08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein sym1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sym1</name>
        <name evidence="7" type="ORF">CLCR_08925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV08"/>
    <dbReference type="STRING" id="86049.A0A1C1CV08"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08925"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05831"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YOR292C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT52338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="265" mass="29856" checksum="2C69065D2D2BD23D" modified="2016-11-02" version="1">MLETSRRKSLAWLNSRYIYGRIPLLHALIFLVELAMAARLIAKFNSYYAQKPVLTTMITNADQVLGGIADTVAQSITAFRARQAMLPSTTDSRYSISSGVELEDLNEKPASLSPDLAPRRSGPQPFDFERLTRFMSYGFIMAPLQFLWFGRLTKWFPIGPKNGNTQALKRVAMDQLIFAPVGLSCFFTFMTVTEGGGRNEVVTKFKDIYLPTLRANYILWPAVQIINFRLMPLQFQIPFVSTIGIAWTAYLSLTNSSEDEAQGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV30</accession>
    <name>A0A1C1CV30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">HNM1</name>
        <name evidence="7" type="ORF">CLCR_08305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV30"/>
    <dbReference type="STRING" id="86049.A0A1C1CV30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08305"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05316"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000046">
        <property type="entry name" value="Amino-acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF7">
        <property type="entry name" value="CHOLINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT52352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="518" mass="56767" checksum="44CDD86AB7AE160C" modified="2016-11-02" version="1">MDMQKPKLESVNEPPPELMLDNDEHRLAEMGYRQEMSRNFSVWSVLGLGFSLTNSWWAVSAAMVTGINSGGPVLFVYGIIGLFIAGMGIAISLSELVSAYPNAAGQHFWVSQLAPERSARFLSYLTGWFVWAGSIFASASVALSVGSACVGCYQLTHPDLVIEAWHVFVAYQLVNLFAFIFNCYGRMLPVVTTVTLYTTLISFVVILITVPARAPSHTDAKFVFATFINNTGWSSSGIAFIVGLINPNWGFSCLDTVVHIAEEVHRPERLIPIGIIGTVVIGFVTSFTFSISMMYSLNNFDDIVNTSTGVPILELFFQALQTKAGAIALEALVIATGIGCQIACHTWQSRLCWSFARDKGIPFHGYLSKVHPTLEIPIRAHAVCCAIVALLGCLYLGSYTAIASIISACIVLPYVSYCIPVTLLLYKGRDNIRHGPFWLGKLGLVANIVLLCFTTFAIVMYSLPTVMPVKADNMNYVSAVYGIIILIIIVDWSMRARRQFRLGTDEIDGLAVMATKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVX3</accession>
    <name>A0A1C1CVX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10621"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03985"/>
    <dbReference type="OrthoDB" id="4150388at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="297" mass="33701" checksum="475A1293B7FE53CC" modified="2016-11-02" version="1">MGPSSMTNLFTFNSLPIFLSFSQYALSFLDRQSRYFDWRALDAEDDGHLVPTKNEKHYYLPPRSLLRAPFTTRKRGILIYLVQELAVRTFVTEMVEQRDHEADANLLHQAILDAIPIGDVQFLRYLLYFAVQVDSANQGFHTGPVNEWESTARSENGKTPLDIGLTLIKRLPVFLGGERGEQYIFEAIKAGHTDVFALLVDHWLLACTDELLGHFDSTLTRLLQTALEGTLPKDGGVDDSAGVRARMLIAARRRAIEGARRVIEYASEKLDRQRPWTPRHLDVSSLGSLHEESFKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWA5</accession>
    <name>A0A1C1CWA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_09732</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWA5"/>
    <dbReference type="STRING" id="86049.A0A1C1CWA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09732"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04133"/>
    <dbReference type="eggNOG" id="ENOG502S6G9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT52784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="66516" checksum="457A86BD711BA3C5" modified="2016-11-02" version="1">MASVPYAQHALALKRLAYTLQWTVGKKVKNLENIITVLSLGSDDDALELLKTIRENAPSPASGHALSVADVLGEWHKSRETDVEYNAESTRLYTTNDLPPERLIHYGVTAYFNCSYTLFYIYEKHEMTDIINRVYRPREPVDKATLCELCALTAIGSHYDAANFDVSVMENLYHTAAVYLSDCIEAHFLRGMRVILCLSMYSFMTKRISARYSLAMGLSIARQARLNGQMPTDLWVPYRKVYRSFVFMEWYAKPEHIALAVDADLDSWLSSSLGYQPGITDEEIKFTSQPITEPQPTIENDIQAQLSAVGLMMAKIVQDVYNSRPMGIFSLARRHSQTLQAWKDSLPPTMKLAELKKEEGNVFIEPHRRSLILVHVMFFGAQMLLQRRLLVTMAQERMNRRWTLDGSYEDGRVIEQQCIAAAEECVYLLDVLGYTRHMFRRCWLCIGHAFSACSVLLFDAALRLLYNQTDGVDEQLARSQECINMLEGCGEADRVAKAMLQIVLPLHQDLRRLASDQPTTRSGIHNLLENPLSGTTSTTTTPEPQIRAAVIPAMQTAIEVLGNPFGHVRRNNIDSFAAGDPSVPSWWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWG5</accession>
    <name>A0A1C1CWG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRELI/MSF1 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWG5"/>
    <dbReference type="STRING" id="86049.A0A1C1CWG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10759"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04234"/>
    <dbReference type="eggNOG" id="KOG3337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="241" mass="27140" checksum="4F2093108973C25F" modified="2016-11-02" version="1">MKFYEHSSTYDYTFPAVALAYFLRYPNPYSRHVLSSDVIDRYIDPETNRLHTVRLHLKKSKVPSAILKFLPRSLAGPGGTSQSYVLEKSTIDVKEGWLETESKNMEWTGILSVVEKQTYRRQRLSDMSAGEIQSQRPKETTACKTVVTFVSHLGHNKLLSRSKPDLAADNEEEPPKQGLFAAWSTAGIQRTIELVGVKRTKSALINGKEGMNVVLERLRSGGIVAVLEGMRRDRMESAEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWR2</accession>
    <name>A0A1C1CWR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin-40S ribosomal protein S27a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_10902</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWR2"/>
    <dbReference type="STRING" id="86049.A0A1C1CWR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10902"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04327"/>
    <dbReference type="eggNOG" id="KOG0004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000008">
        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT52987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="154" mass="17732" checksum="F7510B44F0895632" modified="2016-11-02" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRKKKVYTTPKKIKHKRKKTKLAVLKYYKVDGDGKIERLRRECPTKECGAGVFMAAMHNRQYCGRCHLTYVFDESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXE3</accession>
    <name>A0A1C1CXE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_10222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXE3"/>
    <dbReference type="STRING" id="86049.A0A1C1CXE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10222"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00168"/>
    <dbReference type="eggNOG" id="ENOG502QXBB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF6">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="6">
        <location>
            <begin position="363"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT53203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="453" mass="50322" checksum="4EE2B5459E7D8FE8" modified="2016-11-02" version="1">MKRTGWFSCSHPMVNKLHENAIWSMRGNFLSVPTDCPQRNERLGWTGDIQVFARSANFLYNTTGMLGNWLDDLAAEQMEPWREGVPPFVVPDVITKAHPDDDDFWPHIPNAVWDDAAVLVPWSLYLASGDKEVLEKQYASMTSWIDRGIPRGTDGLWDANIYQLGDWLDPMAPPTEPGNGRTDRAFVADAYLVRATDVMAQACAVLGRDDDANRYRSDCQRLKQAFHDKYVAKSGLLVADTQTALSLAVVFILLDSPDQLAVVGDRLARAVRLQQFRVSTGFAGTPIITHALTSTGHPELAYRMVLEKNCPSWMYPISMGATTIWERWDSMLPDGSINPGEMTSFNHYALGSVVNWLHECVGGISSLEPGWKRVKVRPVPGGGLTSASVAHESPYGRIESSWEIKAGTKFHLEILLPPNTSAWVVLPGEHKKKGSVEEPEEAGRWVTSGETPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXH5</accession>
    <name>A0A1C1CXH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING zinc finger-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_11414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXH5"/>
    <dbReference type="STRING" id="86049.A0A1C1CXH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11414"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00205"/>
    <dbReference type="eggNOG" id="ENOG502ST8T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5405791at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056929">
        <property type="entry name" value="Znf_RING-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25080">
        <property type="entry name" value="zf_RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING zinc finger-like" evidence="2">
        <location>
            <begin position="151"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="285" mass="30115" checksum="67B3F781241C0B0F" modified="2016-11-02" version="1">MPQSPNFPPSTTAAATAATAATTHPTTSVDRRLSAADSISSGANKRSSLPPGFRPFSHHLQGQHGQYNASPLQRTLTPPPPDALGPNDPEPFPSVESLESAGSGQNFHISGSGLPTSASSNENTSPLQYHSHPYQHSQSSSFGSKSDVLEIYCASCGRPWLLKNAFACTECVCGVCSDCVGQIISSPVVTVQPGFAPMRRGCPRCGVMGGKWKVRVCFQLGRNRVDKFAAISARFSITLSQRSQARTSPRALSAWEGSGGSYDSPPTHLPIQQLGKARPGAPKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXK4</accession>
    <name>A0A1C1CXK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MRPL6</name>
        <name evidence="11" type="ORF">CLCR_10417</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXK4"/>
    <dbReference type="STRING" id="86049.A0A1C1CXK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10417"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00175"/>
    <dbReference type="eggNOG" id="KOG3254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000001">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000009">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="10">
        <location>
            <begin position="102"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="10">
        <location>
            <begin position="195"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT53212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="271" mass="29676" checksum="637DC4D02B4DBF00" modified="2016-11-02" version="1">MSCINHLHSPLRRLVREATCSATRDLPAFLVPAITTALLKPRGARPASTLAHTHTPAAPTAPSHQSRIGRTPINVPPEVQLRFYDLPKGNVRSRHPDTPNMAVEVTGPLGQLTVPLPPYLHAQHDEAARKISVRVDDVAEKHQRAMWGTMRALLQNSISGVSEGHLSILRLVGVGYRATIEPTATTVAATYPGQQFVNLKLGYAHPVELGVPKGVTASTPQPTRILLQGVDRQVVKQFAAQIRMWRKPEPYKGKGIFVDGETIRLKAKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXN4</accession>
    <name>A0A1C1CXN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homologue subfamily C member 28 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXN4"/>
    <dbReference type="STRING" id="86049.A0A1C1CXN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09846"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00305"/>
    <dbReference type="eggNOG" id="ENOG502RFG7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1922282at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394:SF1">
        <property type="entry name" value="DNAJ HOMOLOGUE SUBFAMILY C MEMBER 28 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394">
        <property type="entry name" value="YALI0E31793P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaJ homologue subfamily C member 28 conserved" evidence="2">
        <location>
            <begin position="249"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="612" mass="68242" checksum="C6F51EC19C5A139A" modified="2016-11-02" version="1">MSSSGSRLWTCSRCLRGQKLRGTSVGSKARPVRRSRHPFSTTAVSQGDAATETKRDVTRRSKDGTQAAEEQGAMSRRLAEMAEETIDTGSKSDRKLMHDAGFSEELKQQLEEKIAQTSFDAQNQRAASQVNMPRSAGKGTRDIAGADPWTGSESLHDSALRMLDDSHKRLRTPYKPPRPQPVNLRPTPKKNVSAADRLANARDKTSIYAFSQQNDMSEQEREKWRKELKDRFSPGARPMPTTITGLTSLANERIEDAIARGQFKNLPRGKGINVERDYNANSPFLDTTEYFMNKIIQKQEIVPPWIEKQQELVKAVASFRGRLRNDWKRHAARMISSRGGSVQDQVRRARGYALAEERVNPKPLRRVENFSHIASDGTLTTVTVEEKIAAGVSAGELEPQAQLLAHEQNRDHNQEPGQEQVEIKITERPAEDAPIATSGVSAAPVSAITSPTPPTGTSSSSSSSPSPSPSPAPVLPMPHPFRDPAWQNTELAYHTLAVQELNALTRSYNLMAPKIAQKPYFTLQRELDRCFADVAPLLGDEILERSRRPAKIRVEVRGHREGGVLGRFGEEWTGHEGRIRDERAEKGYGFREFWRDLFGEEGGKAKGRRDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXT5</accession>
    <name>A0A1C1CXT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10808"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00230"/>
    <dbReference type="eggNOG" id="ENOG502SBYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22715" checksum="3A8E8E37AFFF1171" modified="2016-11-02" version="1">MSVKRARNDAGRAAGEPDKKKRKGFSVGPANLPDGTYRRKTQKIKKDLIQKAKVKKAYAKVKAQEGLATTHTFASGQPANHRPDPAPSILELHPDRQAMLENDHTRGRQTFTQEDESKLHRNVDGRPGQHRSTQSRYKKELEAATQRKAEIEAKRKAREAREKDRKAMSKAKRPGADGKAKLGRQGTVLLDRIRRLNGEGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXU0</accession>
    <name>A0A1C1CXU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATP-dependent helicase irc3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">irc3</name>
        <name evidence="6" type="ORF">CLCR_09741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXU0"/>
    <dbReference type="STRING" id="86049.A0A1C1CXU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09741"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00320"/>
    <dbReference type="eggNOG" id="ENOG502QT4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16911at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18032">
        <property type="entry name" value="DEXHc_RE_I_III_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="63"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="281"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT53353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="677" mass="75679" checksum="FBBC115456DC9104" modified="2016-11-02" version="1">MLAPSAWLQRLQRLAYTSKCILHPRQARRSLATIVQSPLPPVVRDEAIRLREYQEECIQSVLSYLKRGHKRLGISLATGSGKTVIFTRLIDRVEPPTQNAQQTLILAHRRELVEQAARHCERAYPDKNIDIEMGDIHASGAADITVASVRSLVSGDRLTKYNSDRFKLVLVDEAHHIVAPGYLRVLEHFGLEERRDTGPALVGVSATFSRFDGLRLGAAIDHIVYHKDYVDMIGEKWLSDVVFTTVKSKADLSKVRVGKDGDFQTGQLSAAVNTEISNDITVKAWQEEAGHRKSTLVFCVDINHVTSLTSTFRRQGIDAQYITGATKKRIRGERLEAFKNREFPVLLNCGVFTEGTDMPNIDCVLLARPTKSRNLLVQMIGRGMRLHPGKEDCHVIDMVASLETGIVTVPTLFGLDPSEVVKAARVDDLKELKDRVPDEAALSSAHASGPPLHRATSGDHQLDFTRYDSVHDLLEDTSGERHVRAISQNAWVQIDSYKYVLAAKGGILTLERRFPTTPSASNYATSSRESDSPTFVVIWKQPLHAVEKSKSPWSRPRTVASASTLSDALHAADTFAASKFDRIFIATSSSWRKSPASQGQLDFLNRLREVSEEEPLTERDVTKGQAGDMITKVKFGARGRFDKLMRKKRGAEKEVERMEKVKEMRRRETVKVGPVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYB3</accession>
    <name>A0A1C1CYB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10876"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00459"/>
    <dbReference type="eggNOG" id="ENOG502SS66">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5366256at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20243" checksum="12931B8C198B1A61" modified="2016-11-02" version="1">MSPPITSFPHQGGYFGNPGPPQSTQQDSSHEFSLPHNDSEPHGYYPVGRTTSHASAMSLPPPDSPNALYMHGQPQHSQQPLPSIGMTMQPFPPVPLTLESSPAEIEIMPSRPKPQCWDHGCNGRQFSTFSNLLRHQREKSGSAVKAICPHCGTEFTRTTARNGHMSGGKCKGRPEGHGLNKTKNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYQ9</accession>
    <name>A0A1C1CYQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10996"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="106" mass="11671" checksum="84CA4A9C0BD681D1" modified="2016-11-02" version="1">MLWCWIEVPINCETVAKKRMTLSGIVETNLPSEIHMPKRGAIYVIGVNVKRVRQEDRDVGDEAGGKARDGEDTTHAATLAGQESLEMNTGRKHQTRGHGSTTLQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYT4</accession>
    <name>A0A1C1CYT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYT4"/>
    <dbReference type="STRING" id="86049.A0A1C1CYT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11061"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00586"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11466" checksum="50D76B55EDEE85FF" modified="2016-11-02" version="1">MTSHEQSLRDHVPGTIHLVELEASEHDSKGHIVLHPQPSADPEDPLNWSRKRKLWNIGMVYAYILGVGIPTTVQYSILTNISEETGISLADLNTGTGLMFLFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYU9</accession>
    <name>A0A1C1CYU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">hse1</name>
        <name evidence="16" type="ORF">CLCR_09656</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYU9"/>
    <dbReference type="STRING" id="86049.A0A1C1CYU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09656"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00563"/>
    <dbReference type="eggNOG" id="KOG2199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="218"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="177"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="375"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="430"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="600"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="635"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT53608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="669" mass="73367" checksum="5EC619C5C316070E" modified="2016-11-02" version="1">MFRTQQNVFDDVVAKATDENLTSENWEYILDVCDRVSSSESGSKDVVAAMIKRLAHRNANVQLYTLELANALSQNCGISMHRELASRSFTDALLRLANDRNTHQQVKSKILERMEEWTKMFASNTELGIMEQAYMRLKAQNPSLQPPQAPVKSAITDYDRRREEEELQMALKLSIQDKSAAGPSSQPSDAPAELAAQTPGGAPQQTVPQPVPSGTTAATVSRVRALFDFQPSEPGELQFRKGDVIAVLESVYKDWWKGSLRGQTGIFPLNYVEKLQDPTPEELQREAQMEAEVFGQIKNVEKLLALLSTSTGDMNVRDNEEITELYQSTLAIRPKLIDLIGKYTQKKDDFQQLNEKFIKARRDYEALLETSMAQSAAQYGRPSPAPYGYGPGASGGPPPGQPPAGAVGYPPQRFYTPELDLNEVMCRNIDGQAPNNAVPYPSNPPQPQLGYQPPYPVSSPPPQSHTPSNLNHQPPPPTQPDGYPAYPPTTAAGPVRRQSHPSEAYAGYPPAPPMIQPPNISQLQLHDDAGKDYSPSNYSMDETSNQQSLGPSAPPPPRPQSQPSYPPPMPQGQAPTPSQPPQTSYPPPPQPAPAAYDYPQPNPMSPPPPSHGPPPIPQGAAPGTDPPQHRPVTPLAQSSAYPVFSPTSGPGQHQRQYQAYNQRPTSYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ06</accession>
    <name>A0A1C1CZ06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ06"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ06"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10367"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00671"/>
    <dbReference type="eggNOG" id="ENOG502S6PS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="296" mass="34166" checksum="68D498BD59E19482" modified="2016-11-02" version="1">MLHHIFRLVQGGRLHTAPIDTPQRVLDIGTGTGLWALEFADEFPAAQVFAVDLSPIQPDMTAPNCTFIIDDLEQEWDYPQSRKFHYIHQRSLSGSIGDWTRMYRQALTSLEPGGWIEIQEFEVWFYSQVPGGLPEDSAIVKWQKLVDEASLSFGRRLNYASRFEAHLEEAGFVGIQTQRIKTPIGAWPKDRKLREIGAYLQVQMNEALEAVTLAYLTRALGWSEEEIHVLLADVRKEFNDRSRLLYTYCWFITGRNPEHVDHSSHLKGWHRRKVDVAYFSHPEHGTFTALWALVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZH1</accession>
    <name>A0A1C1CZH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10758"/>
    <dbReference type="OrthoDB" id="3902588at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="233" mass="24738" checksum="222D1BA44CEEE5F1" modified="2016-11-02" version="1">MFNVSLKNPLEAETVSQRRERKARESEGSIRSSTSGSRARLGSERGSIAKKIPIFGFAKATKTRPAVPALSSGGDKPAAKPDGGDVVDDDHVDVDTGPSELAGSPVLVTSPSFSPTSYVEPLSGRSISPSVYRQEVVVDLALINDLAVASAPGRPAEEPLPPLDVPLDRLQQWGKRRSYVCADNAGRASYASPVEPIRLASPVQMERTSAAQAAKYRPERSDPASYVLVPGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0W1</accession>
    <name>A0A1C1D0W1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hyphal anastamosis-8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0W1"/>
    <dbReference type="STRING" id="86049.A0A1C1D0W1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00831"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01677"/>
    <dbReference type="eggNOG" id="ENOG502RFD2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5420724at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT54412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="59421" checksum="19A54CB0E4242A17" modified="2016-11-02" version="1">MSPPSNFEPVSPIDLTADSRRSRRSVGFNISAEDLDEKSNIKASTRSIRTNSTASTRSSTAGGNQPVVRRARFAEATTVFSPASGPGEHQSPFADPSSKMESASTSQAPKPSDVGFGYISDNQPVEQNVYITSDPNGPAGQPLKSALKTPGTASRMLNPLSPTFREEQILEKEELKTEIQQANDLKVKTRVRMAKMVLRGVNFSCSLIVLAMLSTVLTIFHATRNLPNRNNLPAWAPKQKIWPQIVVLSIACVSLLFSIVVILAYCRGGHRRAEKVAVYYTMFAVGWFMFSIVMWLVGAGILHGSKSSGGGQDLWGWSCKDNKRRQLFQDDVHYALVCRLQDWSLICCIIEVVVEVLVIAIYGIVFYRFWSKNRLRKSMDARDRARTDLYLAQLRTQSAPNTPGFAQTPRTPGFPTMIKTPMDAYSAAEQGSSPTQFVSPHSATSNTTASPFKLQAPPSRVTKATPTAAAVEVHPSPSQERSAMLTSPSPPPPTRALSPPMSPPPEERFHAHVAAAPGEQVYEAVPIPGANYVPPSQQHPGQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1U3</accession>
    <name>A0A1C1D1U3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1U3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03190"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04833"/>
    <dbReference type="eggNOG" id="ENOG502SG61">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3979469at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038882">
        <property type="entry name" value="Rcf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39153">
        <property type="entry name" value="AGR244WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39153:SF1">
        <property type="entry name" value="AGR244WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="125" mass="14138" checksum="0AEFFFA2EE30E203" modified="2016-11-02" version="1">MPPPSHITDIAPPQALTPIAASGFAQGALRFGIISFASHFLLNRYTPLYRGLTIQFKVFIQISAMTLGGCIFAERAVGEFNEGVRRRRRALARSERAWEEERELREMVERRHKEEDKVQTPGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1Z4</accession>
    <name>A0A1C1D1Z4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative MFS drug efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_02831</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1Z4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02831"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05004"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000784">
        <property type="entry name" value="MFS drug efflux pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="67"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="592" mass="64278" checksum="3FB90B32AC782366" modified="2016-11-02" version="1">MTAQEDSSSDNVAHSPTLEKDPSHHVEQVHTNERVPGHPGYYEKDGLRTYGDDEDHDHEPPMTVHRALSLVAMAFLWTGSQIPVYLFGGVPPHIYSEIGGVDRWIWFVLAYLLALAAICPFVGSISDLIGRRWVALGGSGLLVIAMIICSVAKNMNVFIVGMTFSGVGAGICELTSLAVTAELAPTRKRGKYVAILVFTIIPFCPSVLWGQLIAYYSSWRYIGLFSGLWACIGFVGTLIFYFPPPRPNSRGLTKKEIIGEIDFVGGALSISGMILFLAGLQWGGYQYPWRSAHVLAPLLIGALLLLVAFPIWEIKFAKFPMFPSRMKKEARILTLTLIITAISGANFFSVIMFWPTQAFNVYGHDPIGVGVRGIPIGFSILTGACVVLWLLSVFRGHNRELMIISSVLMTAGCGALAVADRHNLSTLWGLLILGGLGIGGIVVPASIMTTIICPDDIIATVAALTLSIRVIGGCIGYTVYYNVFVNKFVPNATKYIGGTMAVQLNITNVTYITEAIEYTAASLLPLLRTIPGIEGNDTAYDMVVLAGQIAYAKSYKYVYLTSIAFGGISILASVFLGNINKYMDDHVAVVMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D277</accession>
    <name>A0A1C1D277_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="17">1.1.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Cytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Flavocytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">L-lactate ferricytochrome c oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">CYB2</name>
        <name evidence="25" type="ORF">CLCR_02905</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="17"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D277"/>
    <dbReference type="STRING" id="86049.A0A1C1D277"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02905"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04967"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="23">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="24">
        <location>
            <begin position="111"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OCT54876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="519" mass="56415" checksum="167FE06EC6097670" modified="2016-11-02" version="1">MAPRQLSVSEISSHDKDSDCWIVVDGQVWDITKFAPEHPGGPGIIYKYAGRDATQAYNETHSPAIIKNNLPADALKGILDRSTVTAEWSTPSAQEEPAESKAASSSSSEKPPLESLINAHDFELAARNSATAKTWAFYSSAANDLITRDLNARLFHKVLFRPRVMRRVDKISTATSILGHPVSFPLMIAPAAMARLIHPDGELALARAAQSRRILQCISNNASYSASEIVSQPEVADHPFLFQLYVNRERTKSEALLRGIHAHANIRGIVVTTDAAAAGKREADERVKADESIRNPMMTSSAKNDKKGGGYGRLMASFIDPDLNWDDVAWLRGQTTLPLVLKGIMAADDVKLALDHGLDGVVLSNHGGRNLDTSPPALLVLLELHARFPDIFRRHHPASPAVKAGRARPFSIFVDGGIRRGTDILKLVCLGAVAAGIGRPALFATGYGQEGVESLIDILKDEFEVAMRNVGITAVEDCGPEYVNSGAIDKWVVRTREHPYAVAWAADAEPVIPRRESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D363</accession>
    <name>A0A1C1D363_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PAP2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_02982</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D363"/>
    <dbReference type="STRING" id="86049.A0A1C1D363"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02982"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05105"/>
    <dbReference type="eggNOG" id="KOG2822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="279"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT55015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="409" mass="45546" checksum="29E427BBB5EB35F1" modified="2016-11-02" version="1">MSGSAALEYGFPSTHSTNAVSVAVYCLYLLHQSNEMDPNLKLGLQIMAYFYAVSIVLGRLYCGMHGFFDVIWGSGLGAVLGLVQAAYGPTFDDWLHTGDLKRVLVVTLIILVLVRIHPEPADDCPCFDDSVSFAGVFIGCEYAGWHFARTSYAWSSPTKGTIPFDLQKMGWLVLVARIILGVLVIFAWRGIMKPTLLRVLPPIFRVIEQFGLTLPRRFFKPASEYETIPRQPNDDNIIPQAREIPGLLSNFRRRRAISVGPQSEADAYETLAYRNKKRRDSLNAPEALSSTKEEVSPSPSPDRGYFENKDATQGRKRSSSLEMFRAQMGTGVEALSPLPVLSPAGKARNPQDVSSADELQEQRIFSTIQRPRVRYDVEVVTKLIVYSGIAWWAIEGIPVLFKHVGLAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6X0</accession>
    <name>A0A1C1C6X0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sterigmatocystin biosynthesis monooxygenase stcW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">stcW</name>
        <name evidence="6" type="ORF">CLCR_05695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6X0"/>
    <dbReference type="STRING" id="86049.A0A1C1C6X0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05695"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06979"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF8">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT44283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="498" mass="57057" checksum="86B3E77170357CFD" modified="2016-11-02" version="1">MVREPGYSVEPQWHSQRRKIRVICVGAGAAGLLVAYKLKKSFKDYELVCYEKNPGVGGTWFENRYPGCACDIPAHSYTYSFEPNPNWSTFYAYAPEIRKYFEDFATKYELHPFIKLNSRVQSAVWVEEKGIYEVEIDVEGQKVDDWCHVFINGTGFLNDWKWPKIEGLHDFQGTMLHSADWDTSVDYADKRVAVIGTGSSAIQIIPQVQKTAKKVTAFMRSVTWISPPVGGNILEEDKKHSPDESQKENPQAQYWYTEEEKRTFREDRQALFDYRYKLESGFNSRFDLFIAGSETSKMAEKLIREEMHRRIGPGHEELKERLIPKWAPGCRRLTPGDVSVQTVPQNLADNDTDVEPVHNEITKITSTGLVDDTGRLHEVDILVCATGFNLAFAPRFKVLGVDGVNMADEFNPEPHVYLAVTVPKFPNYFVINGVRGNWANGSALPSHEVQVEYILQCVKRMQEEGIRALEVKMEPVKQLYEHIDAWHLGSVWNLDCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7A5</accession>
    <name>A0A1C1C7A5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7A5"/>
    <dbReference type="STRING" id="86049.A0A1C1C7A5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06471"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07105"/>
    <dbReference type="OrthoDB" id="5416609at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT44415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10196" checksum="A3761053837E79C3" modified="2016-11-02" version="1">MALGVNDAFPLAALHHANHPDNITDKHLQIMRTVILVDSVVNSGKSVLEFIQQVWELASSGLKGHESGQGTIRIIIVTAVVQSQAADKISQVGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7M7</accession>
    <name>A0A1C1C7M7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_05611</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7M7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05611"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07150"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF18">
        <property type="entry name" value="NICOTINIC ACID TRANSPORTER TNA1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="484" mass="53773" checksum="4987F15275B16F24" modified="2016-11-02" version="1">MEEKAVEQLVVENAPSSGKAEAAGAPAVRYDEAETKRILRRIDMRLIPVLSAMYLMSFLDRGNLGNANVAGMSADLHLTGNQYNIAATMFFIPYALFEVPSNLMLKLLRPRIWIPLIMLAWGTVMTLMGLVQDYKGLVVARVFLGVCEAGFFPAATYVLTCWYPRHEVQLRIGYFYGAGALSGAFAGLLAYAIEKMDGVANFAGWRWIFILEGLLTVLFALLAPFILVDDPSTAKFLSRDEADWLMYTIQVENGRGGTESQSAERFKWKYFWAAVQDWKVWVSILVYWGNAIPIYGFIYTLPVVIKGLGYSAANAQLLTIPVYVVALSGTVTAAYFSDKYRTRSPFIIGPQIFGALGFVIIMTIPKEKYPGAVYGCLFIISLGLYTTITGVVSWTGNNLAGPSKRAVVGTNIYLEKQKPNYWLGFGLSMGVLLGAAAAAFFLRVALQRINAQRDAMDVDEIHEKYTEEELWEMGDASPLFRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7Z4</accession>
    <name>A0A1C1C7Z4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">vcx1</name>
        <name evidence="13" type="ORF">CLCR_05651</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7Z4"/>
    <dbReference type="STRING" id="86049.A0A1C1C7Z4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05651"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07261"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="226"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="452"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT44581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="611" mass="65679" checksum="8213000C69860111" modified="2016-11-02" version="1">MHKYRHQAKVAAWYDDPHDERNLNLPFGNPFSKWKPNSRSNTERRLENGLNGSPLAMTQTDDPDNYRPSSEGRGEELGATRAPRHAATTPASKSGTRPYETGDEVDIPRSSSPISEEKAVKEEFPGARHGDETGSDTITNGRPSQPEDTGSMRQRAGGDGQKKRGLKSWFALGMNGGEKDDNNGKDKNKFTVWSQIRATLFNSWINVLLIASPVGIAVYYAGVDPVAVFVINFIAIIPLAAMLSYATEEIALRTGEVIGGLLNASFGNAVELIVSIIALAKDQVLIVQTSLIGSMLSNLLLVMGMCFFFGGINRMEQAFNVTVAQTASSLLFLAVSSLIIPTAFEQWARTGNNASNTETATTENAKPGVAELSRGTAILLLIVYACYLFFQLKSHKEIYNAPSAKNETRPVGAKFKNAVIPDKMRSAKPAGAETPEARVDEPEEPQLSILVALLTLAASTVLVALNAEYLVDSIDAITCGGGISKNFVGLILLPIVGNAAEHATAVTVAIKDKMDLAIGVAVGSSMQIALLVLPLVVILGWIIGKDDMTLFFDGFQIAVLFVAVLLVNYLISDGKSHYLEGILLMILYVIIAVAAWFYPTAPGLSDCPGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C807</accession>
    <name>A0A1C1C807_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C807"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06412"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07269"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650643" evidence="2">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="116" mass="12938" checksum="C4001D8E9AA03BF6" modified="2016-11-02" version="1">MNVCVFILMFLLVPDTSGYTLEELDYVFAVPTRRFISYQITKVLPWAIRRYLLFNFNRGERLEPLYQFERSGGQHGGESGESGESGESGESGDESGQAQTQTQSQGVQGMVKDAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8D1</accession>
    <name>A0A1C1C8D1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8D1"/>
    <dbReference type="STRING" id="86049.A0A1C1C8D1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05717"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07412"/>
    <dbReference type="eggNOG" id="ENOG502S1FV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5330858at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="568" mass="62140" checksum="B8092565E69DB504" modified="2016-11-02" version="1">MAISPAFNICWRDESLQLYDLKYQSVQAQKDTKQANLKRKLNTPHEGGGHLEFVAYYPQLARVIGRRRHQLVAVDITASGSRRLLEKGSNLLHNIGRGMNGQDVTLKQPEKKPSSGHDKSMVVSLPSADWDSLRQRLDQLTLSGDVAGFETAVADHIRKSHSVDELHKAGITVPDFKVNYLISKIFHTTVGSNATHNDRSTTQKRVQIQFYSPRLISWISSQGLLSSRRVERALESISFDAGQTLGAHAIAQALLDADPSCDLLVSCIENGFSPYVEEQAAVVQLLIQRALASLSETAAAEAKPQAKDTMDLDLVSDAPEMQVQSLSATSAENPWLPIPVQGALIAALNRFGTAAGSTISTNLKALLSQREVLALIQFLRQQLFKAGHTRSLQSLPLAEENPRTVRLDATIKLLSACVDAMGPLGFFAALDNEDFVDTLIPELVTEVTNTKQSLDDVAELQGILREALRYQESVQKQRAAGARTRAHTASNASQQRPGAIVTVYSEAVEGEETLQAGSMLPLSLKAQDVVTAGKIRKGGGQVKPRSIRQKRMLERRAKGGYSFERLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8D8</accession>
    <name>A0A1C1C8D8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phospholipase D</fullName>
            <ecNumber evidence="1">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_05364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8D8"/>
    <dbReference type="STRING" id="86049.A0A1C1C8D8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05364"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07405"/>
    <dbReference type="eggNOG" id="KOG1329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000032">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF186">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="1032"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="448"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="454"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="679"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1263" mass="139311" checksum="DB381403469D41B8" modified="2016-11-02" version="1">MSYQQQPEDDGLAYGDDYSRSRGGGGTDRSLLGDIGKKFKTEFDKYKTGSPASQNYGYSSTGGSNQGYYGQQGPTTGYPATGQSPYPGGPPTQQPQGRPDIASKLLTGLHGTLHNIGSDVANLLGPDNNPSQQYASQAPGQAGHSHYAAAPGQPTIVSGPNRYDSFASEKPGNDVKWYVDGCGYFWAVSQALEGARHSIWILDWWLSPEVYLRRPPSQNEQWRLDRTLQRAAQRGVKVKVIVYKEVTQALTLSSAHTKHELEKLHPNIAVFRHPDHLPDAQTAQSSLISSFQSLKLDAAAVSKLGHDALKGIYGVTDDIILYWAHHEKLCLIDDKIAFMGGLDLCFGRWDTNQHSIADAHPSDLNQIIFPGQDMNNARWADFNDVANPFQNKLDRTKSSRMGWSDIAICVQGTVVQDLRHHFVDRWNFIYDEKYNVRKDQRYYRLLDDLPHTASGPGHRPQSRPPSQSGPQPQGSLQASAAAGGYAPPPGSQPYTEPAWHTTSRPHTPGGTYGTAPHSTAHGVQHQPPPTQSPYGQVQSPPPQVVQSPPPPPGIYGQVPGGSPPQATHQPITGAYDHHATPMQAPPQGSMDPYNQFASPPPQTAPVQGPASTASGYQQPTGQSPHQNYPPPPPGPPPQTSPSPATTYPGYPPPPSASPPYTPYQQGATELPSQQSPGLPYQHQSYQPYQQPGSEQARGFDDYGQESSRGFNEYGPGNEDERGFGGERGMRGRFDHYKQEGRLLGQELSSIGSVVSGGLGDRAHQLQGKYLGGTDSYGRPYNRPQGVMTCQLLRSCTTWSNGTPLEHSIQNAYIEVIRNSQHFVYIENQFFITATGDQQKPVKNLIGQAIVERILRAARNSEKYKIIVVIPAVPAFAGDLRDDASLGTRAIMEFQYNSINRGGHSIMEKIAQAGFNPMDYIRFYNLRNYDRINAGGTMQRVEQQSGVSYEDARKQHDDAVGAGYGPLGERTNTAQLSQASQYQQYQTTAQNMGQPGSGRWDSVAECYMLGGQDIRTVPWDGPPEAELDAFVSEELYIHSKTLIADDRIVICGSANLNDRSQLGSHDSEIALLIEDPTKVQSYMNGQPYQASSFAASLRRQLTRKHLGLIRPQYFFRPDPNFEPVGVPNAYDWSSPEDNVVMDPLSDTFQALWNSRARTNTEVFRKAFRAVPDDYVHSWSEYKEFYEYFYQPAETDAQGKPSKLPPRVEYGHVVRADFPGGVRELKELLSQVKGTLVEMPLCFLQNEDIAKEGLTLNALTEEIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8I2</accession>
    <name>A0A1C1C8I2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pre-mRNA-splicing factor cef1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cef1</name>
        <name evidence="14" type="ORF">CLCR_05508</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8I2"/>
    <dbReference type="STRING" id="86049.A0A1C1C8I2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05508"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07436"/>
    <dbReference type="eggNOG" id="KOG0050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="57"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="110"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="241"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="696"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT44762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="783" mass="87574" checksum="1D4EE6EAA9C66D3C" modified="2016-11-02" version="1">MPVVKGGVWTNIEDEILKASVSKYGLNQWARVSSLLARKTPKQCKARWTEWLDPGIRKIEWSKEEDEKLLHLAKLMPTQWRTIAPIVGRTATQCLERYQKLLDEAEARENDELGLGGPEGGETAAPTGDQVRRLRPGELDPDPESKPARPDTIDLDEDEKEMLSEARARLANTQGKKAKRKARERQLEESRRLAVLQKRRELKNAGINIKITTRKKGEMDYNADIPFEKQAASGFHDTLEEEARNDREREMFDPRKQQLARKRQGDAEDNVDAKRQKPDKSKDSAAMAAAARAGQMQRLREAEQQSKRRALNLPAPQVSEGELEEIVKMGIAGDRAVKAAGQDDGDDRGLISQYSNMVGATPIRTPRAPAQEDHIANEIRNIRALTETQSSLLGGENTPLHEGSSSTGFDGIAPRRNEMVTPNPMATPFRQAGAGNNLPGATSMRTPRDGLIINEKGERQLVPQTPRDMRLAENVARHSLRAKLASLPKPKESEWELEVLPSEQEEAAAGSAFTQEDQEEIDRREREAREAAEKAEFKRQTQVYQRALPRPVSIDYNSLASDATSITDPIRAMIAQEAALLMAHDARKFPLPGSKVLGKPPRLDSLPDDLLAQARQQLKEACNETERQSYVESINSLTSSESEPNALPLKFRPGTTPAEYLSAFRTAQQTLLSAAAAGQKLEDKLKLHLGGYQARQKTLKQKIASVYAQIEEQRAQLDGFRTLQISEEGALARRLERLRDEVNFVMRREREAQEDYRAVRDEARALEESTNGVNGHAYGRTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8U9</accession>
    <name>A0A1C1C8U9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">External alternative NAD(P)H-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_05564</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8U9"/>
    <dbReference type="STRING" id="86049.A0A1C1C8U9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05564"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07627"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000005">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 64 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF50">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="538"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT44955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="709" mass="79884" checksum="0B71DCF9983F9D8A" modified="2016-11-02" version="1">MESIPRLARSGRHVQLRYLRSPQSRPSLPRQQWLQTTRPLSTSKLAQIPFRPARLVASQLPSHLVLRPPAGTLRYISTKPLPNRGPVARFFYRLFAWTGIFIVFSGSLVLAFFIYDASTYREMPDATGDIAVSEAALRPRRGGPKNLPIAETLVDDEDCEPMRAQKDKPKLVILGTGWGSVAMLKELHPGDYHVTVVSPDNYFLFTPMLPSATVGTLELRSLVEPIRRIVNRLRGHFLKAEAVEIEFSEKLVEVVQADAEGNKRHFYLPYDKLIIGVGSTTNPHGVKGLENCNFLKTIEDARLIKLKVLRNLELACLPTTTDEERRRLLSFVVSGGGPTGVEFAAELYDMLNEDLLYSFPRILRNEVSVHVIQSRGHILNTYDEALSIYAEKRFEHDHVEVLTNARVKEVAPDRIIFTQMEDGQPVTKELPMGFCLWSTGVAQTELCRKIAQKLGAFQNNRHALETDSHLRLLGAPLGDVYAIGDCSTVQNNVADHITTFLRGMAFEQGKDPEKMHITFQDWRVVAQKVRKRFPQAAGHLKRLDKLFQEYDKDKSGTLDFGELHELLVQIDSKLTSLPATAQRANQQGQYLGRKFNKIAAAIPGFRANEVDFGDLDEAVYKAFDYHHMGSLAYIGNAAIFDFNGLNFSGGLMAVYLWRSIYFAQSVSFRTRMLLAMDWSKRALFGRGELIVRQTSGGLVANDRTDLMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C994</accession>
    <name>A0A1C1C994_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein 25D9-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_06150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C994"/>
    <dbReference type="STRING" id="86049.A0A1C1C994"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06150"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07702"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="860at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 25D9-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT45029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="242" mass="26838" checksum="9DF3BB96EC1324ED" modified="2016-11-02" version="1">MSVKFEKEQVRTMAPAVPGGRDESTAHKIGEALTGGKQTTGYLAAYLKQLQSNPLRTKMLTSGTLSALQELLASWLAHDKSKHGHYFSSRIPKMAAYGAFISAPMGHVLIGFLQWIFAGRTSLKAKILQILTSNLVIAPIQNTVYLSCMAIIAGARAWHQVRATVRAGFWPVMRVSWITSPLALAFAQKFLPEQTWVPFFNIVAFCIGTYINTHTKKKRLAALRKKHYGDGRSSSGRPDDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9E7</accession>
    <name>A0A1C1C9E7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Versicolorin reductase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ver1</name>
        <name evidence="4" type="ORF">CLCR_06195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9E7"/>
    <dbReference type="STRING" id="86049.A0A1C1C9E7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06195"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07804"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="277" mass="28710" checksum="894CD31C2CEB4CCF" modified="2016-11-02" version="1">MARPEETQSASSLHGKVALVTGGSQGIGAATAMQFVRKGLAALAITYVQNSKAAEKTISECLAISPSLKTVAIQADILDPSIGPNLISKTLQGLGTERIDIVVNNAAVLDMGLLQPFTGTTLETFNKMMQGNVFAPMSIINAALPYLPPKGGRIVNISSIAAQQPNIDPVLTYGASKAALESITRSLALIMGIKTGATFNSVSVGPTRSGATLAATELFGQPMIDAAVEPTTAEKRMGVPEDIAFVVGFLASEEARWINGQLIPANGGYKDLLAAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9R5</accession>
    <name>A0A1C1C9R5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_05399</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9R5"/>
    <dbReference type="STRING" id="86049.A0A1C1C9R5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05399"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07866"/>
    <dbReference type="eggNOG" id="KOG4711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF4">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="639"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="668"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="716"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="740"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="778"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="52"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="652"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="803"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1042"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1042"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1060"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1070"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT45209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1090" mass="120830" checksum="E5B17F3FE6C51C6C" modified="2016-11-02" version="1">MSDADQAHSDAATPNAEDGKTARAGAGDSNVEVEETKPPNAGFLWKIQKKLNLDLPTLLLMLKGALPPAIALAAYQSDRWAKTYSTLGYLIAITSFLSLPILPRAKFIQSMILSCITICFAAATALLSIRCAVAAHQPIILTPASTTTGSSGSKQTLQYSGAANVTACAFLFFWLYLANTIRAARPQLFIVSIQFTIFVVVSHTYASTFPTMEAGMNFVDRLLKVFLTGYALASGVSLCIIPISSRKIAQKQAAGLLDMMKASLSIHIAYLHGITTSQSGSPGLLDEKGNPLPLDRNPEARVSMRAAEEAAQSLKVTIQKASQLFGQLKLEIGFAKKEIGWGKLQPDDFRQIWERLQHILLPVAGLSTFIDILQSVKRHKAESENLISDLDAVEAIRKLEAEEWHEVIVMSRVPFLKMKATLVDSLTHVAYVLELVPQPKTTSKDIENSADSAPNPGQPAFAQYLKDQIEIFQDHRRETMRAWCERKGIEVPTKFWEDTSAQYKFSDATSVHETVRQKQNHQQLYLILYLEYLLLSVCQSVLDFVLFADSKVQDGTMSKNRLIFPGWRRIHKLMQNAFKQIDASEGLQDGPASGIYIWLGDALQKHKDPEHLPPTNLYQRITNKLRAIPKFLASDASHFGFRAATASISIAIIGYVRQTHTFYLAQRGIWAVVMVAISMGAHAGAGVQGFVLRILGTAIAAVISITIWYMCDQKPAAIIPLIYLVFVCGIYVILKHPKHLITAVISMVTTILIVGYELQDKKVGTQILTSNGQKYYHIYILAPYRLATVIIGLGVAFFWTYFPYPITTHATLRKDLGDTLYLMANYYSCTHSTVETRLRTTPCLVKDKLADPMRPLDKARQRVFDKLLVMLNRLREHSTFLKYEPTFGGKFPKQTYDELIVHMQSLFNYMALTAYSSHTFQCSGPESDWLKDFRRITARSRLTSPELTSTLCLASASVTNSQPLPPYITVPHPIDIADQLAAIDPGILSITHIKEPCYAAFAVLEIASVLITQEMTAVLSKVRDLVGEVDFSVHFGGAPHSGSTLAGTGTSSDSDLDMRRKGRSPHRHLALHDARENRVDDTEGSKGKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA38</accession>
    <name>A0A1C1CA38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="11">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">bxlB</name>
        <name evidence="14" type="ORF">CLCR_05439</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="11"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA38"/>
    <dbReference type="STRING" id="86049.A0A1C1CA38"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05439"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07974"/>
    <dbReference type="eggNOG" id="ENOG502QQ55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650663" description="xylan 1,4-beta-xylosidase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="671"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT45338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="794" mass="86333" checksum="43CC984A471344D5" modified="2016-11-02" version="1">MSSLATATFVLAILAPVSGQYLFPDCNNGPLKSNAVCDTSGSSVDRATALVNEMTLAEKLNSTGNVNPGVPRLGLPAYDWWQEALHGVATRHGANYTPKGDYSHATSFPQPLLMGAAFDDELIFDVATVISTEARAFSNANRLGLDLWTPNINPFRDPRWGRGQEVPGEDPFHLQSYVKALITGLQGGVDPDVYRVVATCKHFAAYDLENWNGIRRYDFDAQVSAQDLKEYYMPPFQTCARDAKVGAFMCSYNSLNGVPACANEYLMQTILREHWGWNASDHWVVSDCDAVQQVFSSGAHDHAYAATREQTVADTLVAGTDLNCGTYYPNYLGNAIAQGLVEESVLDQSLIRLYSAFVRLGYFDSNASHPYRSLGWSNVSTPASERLAYNAAAESIVLLKNDGTLPYAITPSTTVALIGEWANATVSMQGNYAGTAPYLHSPLYALQQLNVTVNYATGPGQSNPLTDFIPAAVRAANRSDVIIYIGGMDQEDADEGDDRYWIDWTQTQRDLISQVAALGKPCILVQMGMMLDSSQFLANPNISALLWAGYPGQDGGTAIMDIITGTVAPAGRLPVTQYPAGYVNDVPMTDMSLRPGPNNPGRTYRWYEDAVVPFGFGLHYTNFSASFTSSPSSTYSIASLMGNCTDVYPDRCPFQAFPVNVTNTGSTASDFVTLGFLSGQFGPQPYPIKTLVAYDRLHDVQPGSSRITMLNLTLGSLARVDELGNTVLYPGDYALLVDQPTQVSFTPANLAATITTESTLTNRGKAILNFTLTGDEVVLDEWPQPPEQYMGYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAL2</accession>
    <name>A0A1C1CAL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Core protein II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_01541</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAL2"/>
    <dbReference type="STRING" id="86049.A0A1C1CAL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01541"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03465"/>
    <dbReference type="eggNOG" id="KOG2583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="51"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="201"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT45555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="458" mass="48374" checksum="3479EBBE94016003" modified="2016-11-02" version="1">MASPAVLGSKALRASSRHASVRSLQRRGLAAAASGSFQYETGDAAGVKFASRDLPGPTTTLTVVAKAGTRYQPLPGYSDALEKFAFKSTTRRSTLRITREAELLGGELSAYHSRESLVLRAKFLREDLPYFTELLGEVISKTRYTTHELDEEVLNVMKLAQKGLLGSPLSLAVNSVHGVAFHRGLGEPLYATSSVPQLGYLDAEDIAKFSESAYTKENIAVVANGASHSEFSKWVGEFFQDARGGSKLSGPASKYYGGEERIAHGSGNVLILGFEGSSSFTAGSTYRPEIAVLAALLGGESTIKWSPGFSLLARTAENFPGVHISTQHAGYSDAGLLYITLTGNAAQIAKASKEAVETLKKVAAGDVAEEDMKKAIALAKYRALEAGQQTQAGLEATGNGLIEGGKPFQIDEIGSSISKVSADKVKAAAKGLLESKASVSAVGDLFRLPFAEEIGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB15</accession>
    <name>A0A1C1CB15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KANL3/Tex30 alpha/beta hydrolase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB15"/>
    <dbReference type="STRING" id="86049.A0A1C1CB15"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01605"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03602"/>
    <dbReference type="OrthoDB" id="6415022at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046879">
        <property type="entry name" value="KANL3/Tex30_Abhydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026555">
        <property type="entry name" value="NSL3/Tex30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136">
        <property type="entry name" value="TESTIS DEVELOPMENT PROTEIN PRTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136:SF11">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20408">
        <property type="entry name" value="Abhydrolase_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KANL3/Tex30 alpha/beta hydrolase-like" evidence="2">
        <location>
            <begin position="131"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="387" mass="41589" checksum="67753ACF589BFD93" modified="2016-11-02" version="1">MAPRKRKVEATTVINADSTVDDKAPLRRSSRRKAVVQTSDKQQQQGRETTTPAIDEDDDKEKSSTGSATTRSNTALDAGALLAEPEKATAGMHMLSSDPPSREFTSFTIPASKKAAKAISCLRSPVRHPRCLIFTHGAGGDLSAAAMVRFSEGFASSLGEGAGLVMFPGNMNVKARAATFDRVKQHELGEEYMKTAATQGEVNLAYGGRSMGARAAVMASHADEDVKMLVLVSYPLVGPSGDVRDKILLETRPDVDVLFISGDHDSMCDLEMLDEVRGRMKARTWIVRVKGADHGMNLRGGKKLKEGTKAVGATTGKLAAAWLQERDQEKREMDLSWDGEHSDVVSSGWLASAGKGQGEEKGKDIVEEQSSKAGDGSGNPKRRKVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB76</accession>
    <name>A0A1C1CB76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RNA binding protein Nrd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_01432</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB76"/>
    <dbReference type="STRING" id="86049.A0A1C1CB76"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01432"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03684"/>
    <dbReference type="eggNOG" id="KOG0132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16984">
        <property type="entry name" value="CID_Nrd1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000026">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000397">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048892">
        <property type="entry name" value="Nrd1_Seb1_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21380">
        <property type="entry name" value="Nrd1-Seb1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CID" evidence="10">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="450"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="335"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="580"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="372"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT45793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="673" mass="72129" checksum="9B0F75ACF3FD9AF3" modified="2016-11-02" version="1">MSSAVAELDSILQSMLNLKPPGVSGSKITSITTLCTANVQSESVLIQKLYTHFKKTPGTHKLGVLYVLDSVTRQWVDQAKKSGQQLGSGAPDGTFAAGVTRVTELLPVLMNDIIATAPDDQKVKIKKLLEIWERSNTFPAPLLASLKEKLDAPKVSTTPEGSPAPGFVPLGHAAHTDTVAAKPPPQQQDTSAILEALKNMAKQNSAAQPAAPAPAQASLNNLLGAQNGIPQPNSTVIPGSASGVATGQAVNPLGALFAGLSNGVQSQSPANVPANPLAAFLPQQAPALAVPQPAAPLGQDPQAHMQFQLLQILAAQGVPPDQWATALQLLANGGGATVPPPASGNNWAQGQSRDGQTRSPPTQHRRRSRSPGFDRRRDPSPRRGRRDSPGADGYRNDRDGRRGDYRQRSPMRNRRRSPSPAGDLKLPPPGPKNVQFDSALPRGHIKVFSRTLFVGGVTSSEAHLRSLFSAYGVVQTCIVNIDKRHAFIKMINRRDAESARAGMEEHKSGDMQLRLQTKWGVGFGPRDCSDYQTGVSVIPIERLTDADRKWLLTAEYGGTGGAPIQEGMVVEEPDIEIGAGVSSKAMSRRIATDSGGRRGPQSSRNFGGRDDNNRFRDNDRRDRDDRNSNNPNNMPVGVVPNMPFPTNFGNMPGMPTFPPGFQLPNFQPQKNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBG0</accession>
    <name>A0A1C1CBG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBG0"/>
    <dbReference type="STRING" id="86049.A0A1C1CBG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01671"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03699"/>
    <dbReference type="eggNOG" id="ENOG502SK2A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="267" mass="30584" checksum="23CF387B03543FFA" modified="2016-11-02" version="1">MDNEKQENKAPKEKPLHELLTSSLVDIYVGPDSTHWTLHERLLTYHSPFFASIFYGDDKTEEKKSRGNKSYGLPDEDDYPFELLVGWLYSKSIRPPQTEKDIGPLLELYLLSEKFQMEKLSHDVVEVVREFYHTTSTYPGLRRVQYIYAETDEDNEMREMMVSSIARQLTTADKIPSHWASALKRNGQLAVDIIRAIQQWHIEERSIPDVRDGSQCRGRRANGGIFSAIERATDSQETHDTTDTNLGVESINSGQSDTPNVKSDAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBU3</accession>
    <name>A0A1C1CBU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RRS1</name>
        <name evidence="7" type="ORF">CLCR_00509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBU3"/>
    <dbReference type="STRING" id="86049.A0A1C1CBU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00509"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09999"/>
    <dbReference type="eggNOG" id="KOG1765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT46013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="231" mass="26020" checksum="9D39B16769D01BBC" modified="2016-11-02" version="1">MAETSVSVQIPVSTLSTNTSSKPERLPTTVEKPSPYTYDLGYLNAIDPNPLPTTSSLLSQPIAQRNETLKAIARDGAQCLLNTLLTTCPINSTPDGLIMTLPAPQNYLPRWKPLPKPKAPTKWELFARKKGIGKYGGSLKGGAAQEERRKNLVYDEESGEWVKKWGYKGANKKDESQWLVELDDQKIRTEKEGADAGKNVRMEGRRERKERIKRQERRQRGNERRMRKGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC75</accession>
    <name>A0A1C1CC75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC75"/>
    <dbReference type="STRING" id="86049.A0A1C1CC75"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00446"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10342"/>
    <dbReference type="eggNOG" id="ENOG502S60G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5388486at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039970">
        <property type="entry name" value="TF_Grauzone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225:SF2">
        <property type="entry name" value="AT09679P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="53757" checksum="09EB6D98ABD3DBB6" modified="2016-11-02" version="1">MATDANINITAASLRGSPSDRIIKPRPRKDSLQSISGSDTHPGRVVKPRARKSPGSGAKRSEPAKRKFICSFSHYGCDVALSSKNEWKRHVSIQHLQLGFYRCDVGSCNPDFNPNVPGHKRVYNDFNRKDLFTQHHRRMHKPETGPGSGPIAPGNAGDKDWRAFEDSLEEVRNRCWMEKRKPPQRSTCGFCGRVFEGEGSWNERMEHVGGHFSRDIVEAKEEREDEDLTNWALLQGIIKDGGNGRHVLVDQPPTATERPYLARDRDVAMTDAPSSDGISRDAEGSPSLSASSRKPDTESNYPNLDSPREGRRLSNAMSANGTPRAPSAPLLAAAGQALAAAALGATPGSPEDKLQPPPTPERRGYNLAPPPLQGARQSSAPADNGSGDRLEDLINQLIKPKPPKTHRRLTWKCDCNLEMSVDIDDADETAIENLQDISIICSKTSNPYLKVSKSGKYQVVACDELAGYIWKNSKQPVEQHNRPAEVPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC92</accession>
    <name>A0A1C1CC92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_00408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC92"/>
    <dbReference type="STRING" id="86049.A0A1C1CC92"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00408"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10324"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="91"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT46099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="546" mass="59403" checksum="19ED0E712AF0FA7E" modified="2016-11-02" version="1">MEGQDSAAPRTPFSAASTVTLDDAPEVEKGDMPLDSASDVLSQKDLESEGTPDVPVPMKSLVDVSNSLVDFDGPDDPENPKNWSKAKRWGITVSMGLMTFVVTFASSIYAVAIEPVAREYHIGYVPSTLGVSLFLLGFVLGPVFFGPASEVFGRRVPLFAGYLIFAIFQIPVAVAQNVETIMLGRFFGGFAACAPLAVVGGAMADIWGPLERAYGICVFAAAAFTGPVAGPIMGGFITQSHLGWRWTAWITLIMAALFGCIGLAVIPETSAARILQIKAKRLRYETKNWALHAKADESRINFETITRIYLVRPFVMILQEPILALITVYMSFIYGIIYLLFEAYPISFQEERGWNAGVGSLPFAAFIVGITMGTGVIAWSTRTNFARAFKKHGKVVPEERLPPMIVGAAVLPIGLFIFAWTSNPHITWVPQVLATALLGMGCLITFWVCHITLLASGLADVSQQGINYIIDCYGFYSNSAIAINTFIRSIAGAGFPLFAPAMYHNLGVAWATSLLGFLCLVFFPVPVLFYKYGSRIRERSRFTPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCZ2</accession>
    <name>A0A1C1CCZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01276"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09170"/>
    <dbReference type="eggNOG" id="ENOG502SNDB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5344006at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31955" checksum="41ED53E648925C33" modified="2016-11-02" version="1">MPASKMRSRPQVYPRLAFHIVRTIAFISATIVSGILIYFCVQLRHDGFKLPWTFIIVLASTLLSLLALFFTGILYTCFFLSPLFSLILNVTVLILYIVGYGLLTWNIYGTLGHTCSRANWASDDGMMICRTYKALYAFELFGVLAQIALIVLDVRSRHAQTKLGRYNKMADVAAKGGADVKLDDLHSRSLSESQSQSQSQSQSRAVDERDPLGHGHAHSQDSVPYGIVDYNDSRARLRDNAAADVGYGHAPAVRMDDFRHDGPTGGYTAYRPPQTGYANNGYGYGPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD30</accession>
    <name>A0A1C1CD30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tgs1</name>
        <name evidence="9" type="ORF">CLCR_01270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD30"/>
    <dbReference type="STRING" id="86049.A0A1C1CD30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01270"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09104"/>
    <dbReference type="eggNOG" id="KOG2730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000270">
        <property type="entry name" value="RNA methylase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT46423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="274" mass="30834" checksum="0928972C8DE4F552" modified="2016-11-02" version="1">MGKKRKRVERVEATIEPAPKKQNSSTDLPPGVHHYQSIEEVPWDIQKYWNQGYSIFSKYDDGIWMTDDSWYEVTHESVANTIAQHVAEAVPPGRPIIFDVMCGVGGNTIAFALSGKWKRVYAIEKDEATLRCAQHNAEIYGVADRITWLKGDCLKLLGLDGGEMDEQARSFNTLASKLGVIFASPPWGGPGYRDAEVFDLELMQPYSFSYLYESFKKLSPSVALYLPRTSDLRQIARLVGEDKKTQIVHYCTRGSSRALCAYLGDWSPLKLGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD50</accession>
    <name>A0A1C1CD50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">hxkA</name>
        <name evidence="15" type="ORF">CLCR_01172</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD50"/>
    <dbReference type="STRING" id="86049.A0A1C1CD50"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01172"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09084"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046323">
        <property type="term" value="P:D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990539">
        <property type="term" value="P:fructose import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24087">
        <property type="entry name" value="ASKHA_NBD_HK1-2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1250:FF:000001">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000092">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="27"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="227"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT46443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="489" mass="54246" checksum="7D5A2748489702B7" modified="2016-11-02" version="1">MVGLGPKRKPSRKGSMADVPKSLLDEIATLEKLFTVDASKLKQITEHFVSELQAGLEKEGGNIPMNPTWVMAFPDGDEQGTFLALDMGGTNLRVCEITLTEEKGEFDIIQSKYKMPEELKTGTAEELWEYIADCLQQFIEYHHEDEDLTHLPLGFTFSYPATQDYIDHGVLQRWTKGFDISGVEGQDVVPQFQKALQSRNLPIKLVAIINDTTGTLIASAYTDQTIRIGCIFGTGCNAAYMENCGSIPKLKHLNLPDDMPMAINCEYGAFDNEHKVLPITKYDTIIDETSPRPGQQAFEKMIAGLYLGEIFRLVLVDLHENKNLLFEGQDISALKKPYTLDASFLSFIEEDPFENLQETHDMFQEKLKINATKPELELCRRLSELIGTRAARLSACGVAAICKKKNYQSCHVGADGSVFNKYPHFKARGALALREILDWPKGKKDPISLLSAEDGSGVGAALIAALTIKRIKEGNTVGVKDPDSFKGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDG8</accession>
    <name>A0A1C1CDG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDG8"/>
    <dbReference type="STRING" id="86049.A0A1C1CDG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02061"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01303"/>
    <dbReference type="eggNOG" id="ENOG502S3Z9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5223508at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23703">
        <property type="entry name" value="mS26_PET12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058940">
        <property type="entry name" value="mS26_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26163">
        <property type="entry name" value="mS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="298" mass="33797" checksum="93ACE349E4CFAC5E" modified="2016-11-02" version="1">MEALSNSICRSCRLRLLQPSPYRPFSTSSSRLYIPPESPAYIDVPQPLQPVRDSKPRAKGILPLPRELFPARRPDKPSQGYLDDVTRDPLPKNVLPEDQLTETGKYKRRMAELRKTHLRSSLTELHARKTSIDNTIAARSAAKQLDRARLLSQAEREDARLTNVSIPSAMRPQKLHQLTPEEEQEIYNSRLAAHRATLAAKHEDRLDNLHTLYMNARNFITTKEQLASAIDQAFDSSRSIWDKEGKPDTVETMIARGRDRSADDGRGGTMLPGDVTERARKDQERMKKIAERLSGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDL5</accession>
    <name>A0A1C1CDL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoacyl-(Acyl-carrier-protein) reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_02033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDL5"/>
    <dbReference type="STRING" id="86049.A0A1C1CDL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02033"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01342"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF111">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_1G10100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="321" mass="34073" checksum="E48A76FCB2D3A4BD" modified="2016-11-02" version="1">MADRPPSRRVFSSTNMPKGIAYRPHEGKFGIVTGGSRGIGAAIARNLASKGCSLLLVYTSDSSTEPTQALCKELAEENDILCVPVQADLADPSRAAPHILATAKNHFAHPRTGTLQVDIIINNAGIAGNKLLNDPALGPIEETQFHQQYNVNVLAPLLLVQACQPYLPKDRSGRIVNVSSVSASIGCESQSIYAGTKAAVEAMTRVWARELAENCTVNAINPGPVWGDMYSQAGESFWKTNQKYVDSAPLMTYTAGNDAVRARAGGDPEEYDNIVLKGMGGKRPAFTDEIAGVVGMLCSEESGWTTGSVICANGGMKMSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDR8</accession>
    <name>A0A1C1CDR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CLCR_01867</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDR8"/>
    <dbReference type="STRING" id="86049.A0A1C1CDR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01867"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01316"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000488">
        <property type="entry name" value="Related to severin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="7"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="347"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="518"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCT46586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="665" mass="72331" checksum="8D14E080AA32A377" modified="2016-11-02" version="1">MDPEELYTKQNCIGGGSFGKVYKGVDKRTGQAVAIKVIDVENAEDEVEDIIQEISILSELQSPYVTKYHGSYLKGSDLWIIMEFCSGGSCSDLMRPGLIHEDYICIIIRELLMGLDYLHSDKKLHRDIKAANVLLGQNGQVKLADFGVSGQLSATMTKKNTFVGTPFWMAPEVIKQSGYDHKADIWSLGITAIELAQGEPPYADIHPMKVLFLIPKNPPPQLQGNFSRTFKDFVDLCLRRDPRERPSAKELLKHPFVKRAKKATYLTELIERNERYMATRGGRSSDDEDEEEDVRPAFHEPENEDLWDFGTVRPVGGRGAGLRPMNDSAANARASAEPVAIAKSKNDWEETVKVPSSPQKSPVKAAFPPTPANIPLPPSPAKVTTSAATEKPIPSALPLSVSATRKTPAVPLTNKALPAHPQRDSPGSNEYNKAFQAQLAKDMGFLKLDVGSSPKTQPAQAQTPPGKKAPMVIPEIPPFKGRPGRGEALQQGQQTPPSKAVPSSSSYTGESSAGPASIANQQPLPPLTTKTNGSQPSEPATPTGTSSRPAEERTDQELTALNSVLIPALEASMHRRTYMLKELARTSKLSSSAAADMHQHRVQAHEKVRKLAAKAAGVFYEIQKCDEECPVGMGGGVTEFLEGFLEEILVRVEAADEPDPAPGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDS1</accession>
    <name>A0A1C1CDS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RPEL repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_02132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDS1"/>
    <dbReference type="STRING" id="86049.A0A1C1CDS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02132"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01359"/>
    <dbReference type="eggNOG" id="ENOG502SC67">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="197676at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043451">
        <property type="entry name" value="Myocardin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793:SF12">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="144" mass="16718" checksum="5CD247534B3EE314" modified="2016-11-02" version="1">MSNSIEENKPDLKVDESPISPLERRNSLEKHLQYRPDVQDLKNRNILYDTNAAPSLQARQHELERQQQSDSLRKHLEKRPERDELVERNILPDSNAAPALQASQKALQKQMRADSLDQKIQHRPKPEDLIKEGILETDEDPTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDZ7</accession>
    <name>A0A1C1CDZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type E3 ubiquitin transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_01840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDZ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CDZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01840"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01469"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22585">
        <property type="entry name" value="Rcat_RBR_DEAH12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF13">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="514"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="518"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT46754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="87433" checksum="CFF6A85FE6C0621B" modified="2016-11-02" version="1">MTTCKFFVRGRCNRGQECKFAHLPSPKLQSETANTTTLLRAGAPYFLPTSRPIPTCRFWLKGGCWNGIECAYFHPAVSQPTAAAPTTPRKSGATLERRLKGAYVRFGDGALVLHVQLSSTTARFASSDNSNTRAGRAQVCTVLCSWYNPSRVVWLHYRSDTWASTAIKRFDGRFYGRQIKTKLQPPPQHHANGKAIWSVQLSNVAADVTQERIQEHLQGVVPDEVVMGRPTLEDMDRKPEKFVQALFSQSSRKLRSFELEKNATGSRTKAFAQFERASDVRAVLAYNGVEFPEIGSKLYVDQVAAVRVAVVRELYAIIKGNFHKLQADNKDGVRISTHHRPPSKIVDLRIYGPKLEAVARLKAQVAQMLVGRVVLNDCGTALWHEFLASDAGISALQALSKPGEVYLYRDTRKLQLVFFGTSSLFANVRRAVIHVLTSHMSHYLMPLEGDLFAEALSGGLRRVIRHFGKRSAWLDVLRTPPAMIFRGSPQHFEVAKSLITDPSAVVPIDQRTGPSNECPYCFLSIADPVELRCGHSYCRGCFEALCRDLGASENPITCFANLSGCGEKVSLEEIRKALDNSTFEAVLESSFEQYIRSKPDNIQYCPTPDCPSIYTVSETPGVFTCDNCLISICSKCRALSHDDLTCEEVQGQNRVEEIVSDEEKKKLGIANCPKCNVLIQKKDGCNHITCMCGIHICWFCLATFASDEECYGHMSQAHGRFGELNAAEEQIRELRADGFDWVMLLLRAAENMEDPDVWQRQRHAEVGWQLQRLAEVRRHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE65</accession>
    <name>A0A1C1CE65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Putative ATP-dependent permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ADP1</name>
        <name evidence="18" type="ORF">CLCR_01805</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE65"/>
    <dbReference type="STRING" id="86049.A0A1C1CE65"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01805"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01460"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000702">
        <property type="entry name" value="ABC transporter (Adp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650759" evidence="15">
        <location>
            <begin position="22"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="833"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="868"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="909"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="946"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="976"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1064"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="370"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="645"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT46746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1090" mass="119670" checksum="39D52B8CBE9E51C0" modified="2016-11-02" version="1">MYLNALAAAFVLVSPIWVTAAYRNDTSAALMQDPFLELVDGCPPCPRCFDCHYDEFKCLQFASCGSVNGKCLCPPGFGGDDCAEPLCGSLADGKNRSPRKGDKCDCKDGWEGVNCNVCTSDQACNALMPLGEGGVCYKKGVLVQENFQMCNVTNKAILDQIDPRIPQVTFSCNAEAATCNFQFWVDQKESFYCALDNCTSSYQDTNVRNTTKYTCQNINCSCIADRFLCGEDGSVNIDEFLEEEIKGPASFYTQHTYGGSSKDGSRFEEPAMNNLISMIFGDEYISLQCRSGECLYETDVPGFTRPIKEINTPLIAGVIAGCALFVVAITLIAWYLSHRRALKRWGAIRLGEGTEDDAAASMINHTPMALQFENVSYGLKGKEILSGISGIAHPGQITAIMGASGAGKSTFLDILARKNKRGAVVGNMYVNGEKILDAEYRNVIGYVDQEDTLLPTLTVHETILTSALLRLPADMGISVKEQRVIEVMQQLGIYHIKDQIIGSAEGNGRGISGGEKRRVGIACELVTSPSILFLDEPTSGLDAFNAFNVVECLVTLAKTYNRTVIFTIHQPRSNIVALFDQLILLAKGKTVYSGPFSSCQSYFDHIGYSCPPGFNIADYLVDLTMHASLPRSPVFEDVPRDLLDRDAPETESSSTRAVKSIASVSNVSVESPREPSLRIKPKRRISLKQKQDRQLFTRKKATGNETPPTPKTDDEDTIIGKATGSMRSWLQMSRRDGSNPPPLLEDPDDLPPDANTDLDILVTNFKNSDVAQTIHDEIASSIQAASAANGHSSGSAVGEPVTGSIKGFRRVSLPRQFLILSKRTWRNLYRNPILMLTHYAVAILLAVLSGWLFYGITDDIGGFQNRLGLFFFLLALFGFSALTSLNVFSAERLIFVRERANGYYHPLTYYAAKLMFDIVPLRLIPPIIMGIILYPMCGLLPKWGVFFTFILVLVLFNLAAAAICLTIGIVFKDGAVANLIGSLVMLFSLLFAGLLLNLNHDTVQQAAQWLQMLSIFHYGYEALIVNEVAKLRLKDHRYGLDIEVPGASILSAFGFDNLALWKDVIGLGVFAGAFIIIAYIAMHFLLVEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CET9</accession>
    <name>A0A1C1CET9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
            <ecNumber evidence="2">4.6.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_02656</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CET9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02656"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02387"/>
    <dbReference type="eggNOG" id="ENOG502SA4T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5425539at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00606">
        <property type="entry name" value="fungal_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048269">
        <property type="entry name" value="RNase_U2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037430">
        <property type="entry name" value="RNase_U2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650770" description="ribonuclease T1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT47033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="152" mass="16204" checksum="D8C7A52AFE5608BF" modified="2016-11-02" version="1">MQLSQILAGVLIAVTPVLALPPGFPSTKSPASPSLWPREFSPFAKRQSCVETCANVCYWQSDIDAAVSRGFELLESGQTLGSGDYPHQYNNFEGFDFPVSGPWYEFPILSSFQVYSGGSPGADRVIFNGNGAYAAVITHNGASGDDFVACAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF47</accession>
    <name>A0A1C1CF47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">allantoicase</fullName>
            <ecNumber evidence="3">3.5.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_02480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Utilization of purines as secondary nitrogen sources, when primary sources are limiting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>allantoate + H2O = (S)-ureidoglycolate + urea</text>
            <dbReference type="Rhea" id="RHEA:11016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="3.5.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the allantoicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.4" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF47"/>
    <dbReference type="STRING" id="86049.A0A1C1CF47"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02480"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02286"/>
    <dbReference type="eggNOG" id="KOG4145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000078">
        <property type="entry name" value="DAL2p Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000059">
        <property type="entry name" value="Probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="8">
        <location>
            <begin position="55"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="8">
        <location>
            <begin position="242"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="399" mass="43369" checksum="2012165665BA7EF3" modified="2016-11-02" version="1">MEVNIQPHALVENVVDRALPSSTSSTSNVTVTPVPASLIDTTFSSSTNITTTVLGASILSFSDEYFASASNLLTPTPPIRKPGVFVHTGAWYDGWETRRHNPNEYDWVVIKLGCVARIEAVEVDTAYFNGNEAPLAGLDGCSLTKEEEEEGKGSGVEKEDFKGWAEILPPSQCGPSQRQAWKVSGPAVQGKEFTHLRLKQYPDGGIARLRVYGTVVPPSLPASVTSGKEERPQEDLAAALNGGVAIACSDQHFGGKHYLVLPGRGKDMGDGWETARSRVKGHTDWAIIKLGLKGRKIEKVVVDTKDFRGNFPRAVKVEAWATEVAKAALGTEADPEADGEGWTELVRGEQPCQADYEHEFEGEQLVVSEPPEGHVWTHVKMTIIPDGGVKRLRIFGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFC1</accession>
    <name>A0A1C1CFC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DIL and Ankyrin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFC1"/>
    <dbReference type="STRING" id="86049.A0A1C1CFC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02270"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02264"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="396"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="698"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="832" mass="93407" checksum="F271E22250F59829" modified="2016-11-02" version="1">MDVGDPATPTEAHSHSQPQSPSQETPRKLPDDLPTSLDDRRTFANYGEETEMYDGWQGSSQYITAPTPARTLTFDLHLDTPAYDEETFARIQDSESRLMEMVAAQAHHRQGGSPGQDEDAIATDDNLSDDEKKEILQKSLNMAASNGDVSRIQKLVGGKAKQYVDVNQPDEEGTVPLIYASCFGHQEVVAALLNAGAIVDKQDRNQWSALMWAMTNRHKQIAKLLLDHGADPDIRSSSGGTALDFVQPGSDFSHYLHENGYHFGSSSSADDFYNSGFSQDRFEEEMAENEMKRRMLMQESAANLEVDLSTLGFDEQPESPTDLDNDEEEFIWDRCVGDQMFVFQADKLEAIFDLIISNMTPQRSPSQKPVPANLIFLMARYAHYHMTASLLDDVLTRAMDLINDVIERCQWDMTMLAFWISNATLLLHYLKKDAGLVQVTSKYQLELAELINEIFILIIRDAERRMNKVLDVAMLDHETIPGLDDIAFQGEWKVFKSKPKTKDEPPEKRFRPPSPKRRAQTSPRNITSLLSSTLFVLDLYDVHSVITAQILSQLLYWIGAELFNRVMTTKKYLSRTKAMQIRMNVSVIEDWARTNNRQPEHYENGSTISTGENTVDGARRHLAPIIQLLQWLQCFSSLGEDHESLVGTLVQLQRLTPTQLIHAVKNYRAEVGEKSLPKAHMKFLTQLQRGEQSLIKRPLTPAIDAPESGTATPTKRNGTPVPANKDPSTPQRPSAPPTSSPIEQDTDPPMKRNALTLDQSLMLPFSLPTSTDMLISYGAGIGGTNREQARKYIPTVPTEVLSKLNLDGDSIRRRESMSTIGTTVQGWQGNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG49</accession>
    <name>A0A1C1CG49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase sigma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG49"/>
    <dbReference type="STRING" id="86049.A0A1C1CG49"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03441"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01925"/>
    <dbReference type="eggNOG" id="KOG1906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF50">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="181"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="556" mass="62492" checksum="C80C6D46D7EB8C2A" modified="2016-11-02" version="1">MPPNQLIIHRSPYTRRYEAASNLFCQYARGKSRTSGQHCSLAGPRACSAHIHTSIPDRPTTFTTEPNIDIKSLENTLRAHREANREPVVRKIYKKGESVWIKDRDGGLPALKVKVPRKDIGLFKRVDLSPITALRGTNRDLDALWRIKDTEKNPPLQYRLPWLRHLDSTDSRAPSAAIERLTAEIRAFEKYSSPSEEEQRAASDALNDIIDCIKDIDAGLIVDVIGSRATNLADPLSDLDINVASPEQCVILDNPAQEAPFRVLKKLYRALQKPSKNNNQSDSRRIETHYYLKQARVPILLCRHKPTGLPIQIQSTPRTYDSREYVKASLREYPSLKGLFKVLKQLLQMRGLTIGSAGGITSYPLLQMIVATLKFSEARFHPADLGGQFLLFLDFYSDIDFSTHGISTEPLELFSKSVGRGPDCDEEADDASDGLETPPQSHITFKGRTRRRSPKSMSHLMTLQDPANPINDLGKSCFHIKDVQETFIALRTTLKRAMAEWDAPSKAPTRSGGQSVARSLLEPCVGGDYTIYEHERDDLRRLGRRSLQKLEEATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG75</accession>
    <name>A0A1C1CG75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_03630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG75"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03630"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01884"/>
    <dbReference type="eggNOG" id="ENOG502QR14">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000021">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF236">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="192"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="304" mass="33880" checksum="7E8F97F5FDBF3E9F" modified="2016-11-02" version="1">MRTTILEKLEDLVVGQSQQMPGCVLFQTKRAVENLRVLCYISVYHDAPLLVNATTIALLKSSPSMAPRAKQRPAQSKTDGVQASKAVPPNWPPLNPVVPAEHLIIETVLAGQILVVRNLFTSSLCRNYTSFLSSLPLTTTPGKPKRGEATRVNDRFQVDDPVFARTLWEQSGLQSLVNSFEDQTMFGGKVLGLNPNIRVYRYRPGQFFDKHYDESIRLQFGQAKLHAKTTWTLLIYLTTCDGGETAFYPEPSKKGEAPPEPILVGLEAGMGLLHKHGDDCLLHEGKEVRSGEKWVLRSDLVVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGF4</accession>
    <name>A0A1C1CGF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative major facilitator superfamily transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_03343</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGF4"/>
    <dbReference type="STRING" id="86049.A0A1C1CGF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03343"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01823"/>
    <dbReference type="eggNOG" id="ENOG502SISJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10027823at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="470"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="2"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT47562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="626" mass="68628" checksum="BD9A87FAB599720B" modified="2016-11-02" version="1">MSMILRPFTWFYHEFGIVSIHETGRNAWLIILARSCRMFAYGTNSLILAIFFSALNYSDHQIGIFMTLTLLGDVFLGTFLTLIADRVGRRRVLMGGSVLMIISGLVFAVFENFWILLLAAILGVISVTGGDFGPFRSIEESVLSQLTTSTTRADVLAWYVTTSTLGSSIGSEVSGRLIHYLQARPGWTDVDAYHSLFWIYLIMGIVNVLFVLLLTDACELRANDKGEEMYSRVPQEDHNRHEDDNDEAVLHHQSQSHPNGTAEADVEAASPPPTPTPSPSRPRSPQPSTIPSSRLSRALSAFSSALSQISKTTRRTMYKLWFLLIIDSLADGMVPYSLTNYYMDVKFHPSKSTLGDVTSLSYFLGAIGAVFAGPLARKIGLINTMVFTHVPSSTAVLLFPLAPYFWITALFLLVRTGLNNMDQAPRSAFIAAVVKPEERTAVMGITSMLRNLAAMCGPTVTGVLAEGDRFGVAFIAAGVCRLVYDFGLYALFVGYERGKKLQDRRDDEDEDEEEDVDDQRGFIIANGQRHGQGHRRDIPDDTGGADADRFELESLADSDDSDSSDNSNDRKTRESEKTAVAVAVAAPVRGPTTTATLNGGLRVPLGSGGSPRVRSRSPHHRSSASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGW7</accession>
    <name>A0A1C1CGW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">icl1</name>
        <name evidence="14" type="ORF">CLCR_03421</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGW7"/>
    <dbReference type="STRING" id="86049.A0A1C1CGW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03421"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04634"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8 10 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="423"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT47707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="537" mass="60022" checksum="283E22F770FE3DEA" modified="2016-11-02" version="1">MSPLDQEEQLYLQDVEAVKQWWTDSRWRFTKRPFTAEQIVQKRGTLKIEYPANAQAKKLWKLVEERFATKTASATYGCLEPTMLTQMNKYLDTVYVSGWQSSSTASSTDEPSPDLADYPMNTVPNKVQHLFMAQLFHDRKQREERLTTPKDKRDSVANVDYLRPIIADADTGHGGLTAVMKLTKLFVEKGAAGIHIEDQAPGTKKCGHMAGKVLVPVSEHINRLVAIRAQADIMGVDLLAIARTDSEAATLITTTIDHRDHAFILGTTNQNLQPLNDLMVAAEQAGRNGEELQAIEDKWMEEAGIKLFDEAVIDAINAGVHVDKAALIEKYKTASKGKSNNQCRAIAKGLTGVDIFWDWDAPRTREGYYRYQGGCQCAVNRAIAYAPYADMIWMESKLPDYAQAKEFAEGVHAVWPEQKLAYNLSPSFNWKAAMSSSDQETYIQRLAELGYCWQFITLAGLHSTALISDTFAKNFAKRGMRAYGELIQEPEMANKIDVVTHQKWSGANYVDNLLKMVQGGVSSTSAMGKGVTETQFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH31</accession>
    <name>A0A1C1CH31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH31"/>
    <dbReference type="STRING" id="86049.A0A1C1CH31"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03774"/>
    <dbReference type="OrthoDB" id="4121293at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="88" mass="9979" checksum="08E847DEB72D752C" modified="2016-11-02" version="1">MARPFHYPFQYAQLPTYGYQTFDPSAVSFSFHPIIPPDRLYPSKPFADDQMKPEEEQPPLSEDNPEPQNDAPAEANGKFGVSVLSFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHC7</accession>
    <name>A0A1C1CHC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein farnesyltransferase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Fntb</name>
        <name evidence="9" type="ORF">CLCR_03481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHC7"/>
    <dbReference type="STRING" id="86049.A0A1C1CHC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03481"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04433"/>
    <dbReference type="eggNOG" id="KOG0365">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000014">
        <property type="entry name" value="Protein farnesyltransferase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="8">
        <location>
            <begin position="65"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="459" mass="49992" checksum="563651AC28086434" modified="2016-11-02" version="1">MAASDKAEYQIPFYYRCEPPLLDALETETSTVQDKTVKECMPLLNEADDASRSLLDFNEFGLPKLEREKHIEFLHENLGEFPAPFVGIDASRPWMVYWALLGLYLLGEDISVFRSRVVETVYSMQHPDGGIGGGFGQYAHLAGTYAALLSLAMVGGEEAYGLIDREKMWHWLGRLKQADGGFQVSEGAEEDTRGALCGLLAISLLNLPLSLPPDSPARAAGLETFMDGLGEYLSRCQTFEGGIAASPGGEAHGSYAFCALACLCLYGPPDKAINKFLDVDALIWWLSSRQYAPEGGLAGRTNKLVDGCYSHWLGSCWPLIQAAVSGPRNSAGSNSLGVGENLYSSEGLARYILCCCQAEEGGLRDKPSNTVEHSHTYALADEDGDPFSSAFSWEVSKAQIRSEQNGGKLFDTGAHVNKIHPVYTIPHDAALAIRQWFLSRPLNVEAARQLPHRTGRDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHW7</accession>
    <name>A0A1C1CHW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Lysophospholipase</fullName>
            <ecNumber evidence="2 8">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_03873</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 8"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHW7"/>
    <dbReference type="STRING" id="86049.A0A1C1CHW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03873"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08252"/>
    <dbReference type="eggNOG" id="KOG1325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6121437at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00147">
        <property type="entry name" value="cPLA2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="10">
        <location>
            <begin position="175"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="604"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT48100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="820" mass="90895" checksum="2882FF7CDDE0778E" modified="2016-11-02" version="1">MGAARLLNTASRLRYPAIALAAAACAGIHSSTRRSNLVRLDSPPSPQIPQDASLIAYGRRLQSHYAQVEDPKHATKRGDAAIIDRSNDPDRYVPLFESDDENSWAAFSRNFDNVTEGIARIEWATLGDKIVDWVVPNWAKLLPDGFAKLQFELSMEPGSLADEIWREAHDPSINPEITWNATVRVGDALGKDELEFRRKRKKYVVKALAKYLDIDEKEIHPDDVPTIAMCGSGGGLRAMVAGTSSYLSAQEAGLFDCVTYTAGVSGSCWLQTLFYSSLGKQDHRQLLKHIKSRIGTHIAFPPPALKLVTSAPTNKFILSGFIEKLKGDPGATFGLVDIYSLLLAARLLVPHGDLAVNDADLKLSNQRMYIENGQYPMPIYTAVRHEIPVDVEEQEAAKGDLALKQKVREVARKEAWFQWFEMHPWEIWCEEFGAGIPTWSLGRPFKNGQNLVLETGVTLPEIRQSLLLGIWGSAFCATLSHYYKEIKPALLGMVGFDGINMLLEGKDEDLIKIHPIEPATIPNFVYGMDGQLPSTCPDSVFKTDHLQLMDAGMSNNLPIYPLLRPGRDVDILIAFDASADIQKENWLSVVDGYTRQRGIKGWPVGAGWPRASSKPEEHAKALAEAEASTAQEAATKLAEAREEDREQKAAASSSGGKSNAPESPTTGSAPDAASTLGPCSVWVGSKAERSSEEEPPPSKTLDWDIPDSDTENPSSPQFHLMSPDAGLAVIYFPLLPHPKVPGVDPDKSDFMSTWNFIYTPEQVDKVVELARTNFSEGEEKVRRTVRAVYERKKKERKEREERMKGKEWKWRMRNAADSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHZ5</accession>
    <name>A0A1C1CHZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHZ5"/>
    <dbReference type="STRING" id="86049.A0A1C1CHZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04444"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08295"/>
    <dbReference type="eggNOG" id="ENOG502S6YK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2100988at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="84" mass="9651" checksum="857B7499A4309812" modified="2016-11-02" version="1">MGGGGKIPYPKHVWSPAGGWYGQPQNWKSNTIVMGVVIAACTALAWRVSAEREMRYKMPREDVFFPSRFWSRQIIEHEKAQRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI52</accession>
    <name>A0A1C1CI52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTPase-activating protein GYP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_03856</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GYP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI52"/>
    <dbReference type="STRING" id="86049.A0A1C1CI52"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03856"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08263"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000044">
        <property type="entry name" value="GTPase-activating protein GYP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="353"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="385"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="729"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT48111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="864" mass="94774" checksum="44C4F27F0D182610" modified="2016-11-02" version="1">MATTAEHSEVDEFEDASEAKSNSKRESSSSDQPPSNANDDEQAKDPQRESTGSSESKTPDITTTQPAADVDTKNELQTSTLKPTESLSSTSGDPTEKSDPPKPPPRPSRFQGFASSLPSVPWGAPPPPPKKPSNDARAPSPQPPVPPQPQATSTWSRKATTPFGWLSRATSAPKETRSPPLPSRSQLDTRRNTAASTSTLGSNPDLMLKALEEAQDGSGGSKRASLREQFKMLRMREEAGITSLEGTESAEGGAIAGLVGRSTSLSVGIATPGTVNPDENVVSTPVVSPTSPMTETLPTNPNLPPGTVSGVAAAAANTAIPIDWDFWQNVVNEGPQAVARTSPDEFTQAISGGIPQTIRPVIWQVLAGSKNEDLEAVYWELKSREPAKEGMPKSPLLNGNLNGSIKEKESTTSSRSSIRSDHSTPATSSNVGVASPSPSHEATDPLSTARLQTQLAAERAKKAKEDSAALSKLEKAIKRDLGSRTSYSKYAVAAGLQDPLFHVLRAYALFDDAVGYPQGMNFMVIPLLIAMPQEEAFCLLVRLMNKYQVRDLFIQDMPGLHLHLYQFERLLEDLEPALYCHLKRRDVTPNLYATQWFLTMFAYRFPLQLVMRVYDLVLCEGLEGAILKFGMAVMQKNAATLLGMQDMQSLTNFLKEKIFDAYIDATPSSKSLLESGFFGSSGGSENEVYRADLLVQDACAVKLTPDMLNRYREEWETTTKAEKARETEMENLKTDCATKAAQIRSLEQRAEKSDAEHIEIANELVRLKVENNELHDQNESLTGQVAELKKVAESEAANVEERLKATTEQVMQRNIEVQNENRHMEEQMAEMERELVEMKLKYAELNAEHEGLKQKWNDLKRALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI54</accession>
    <name>A0A1C1CI54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_03986</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI54"/>
    <dbReference type="STRING" id="86049.A0A1C1CI54"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03986"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08351"/>
    <dbReference type="eggNOG" id="KOG2486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052279">
        <property type="entry name" value="EngB_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498:SF1">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EngB-type G" evidence="6">
        <location>
            <begin position="94"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="423"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="622" mass="68346" checksum="E787C1E5154E0045" modified="2016-11-02" version="1">MHTSTCFNCRFVSRYLFQQRLAELQNGRRRLSSLSQVDIGPSWYWDTQPPTKENLAAAAHFFKNHKPSRLWTGDLWKTSELWRRSKKSSAQKILVPEVVFLGRSNVGKSTLINAVTSIDLNRVSTTPGMTEVMAAWGLAAKEADGGAIKGWDGDVTPKVTLVDMPGYGFGSRSEWGTQIVSYLNARRNVRRAFLLVDSVHGIMAADRHMLEIFQKLGIPFQLIATKCDRLRSSGGSESEIREVLERLKDQANRDKSALMLGEIIAVGSLQEAAGTKPKHDGFGIRNLQWAILKAANLEWYAMDKAAVHKVIDKSATQRPQEKIQAEISHLLQKRGDDTQAETSPDTGASASSESPPNLGLREFMREILGTGSEAGSSAASPSQPNRNPPRVFDPLTSDAPGTARWKAPTNMQDQLDSAYQELQKHMHAPSPQDDRDPTLSHQPTRPSTNRVTQRPGPARRMDQGVDAFESIFAELSPQHTPAPNRRQTQQKKAAPAPTPTPQSSRKPASGQQQQQQQQQQQQQAPPLTGKGVSLGLDAFEAMFAEPPKQTKAKSKKSQNSARQGRKAGASSGQPAAHQAQAQAQAQRPKEPAMVGKGVSRGIDAFESMFAEPALGQKARRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI82</accession>
    <name>A0A1C1CI82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">crpp0</name>
        <name evidence="8" type="ORF">CLCR_04199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI82"/>
    <dbReference type="STRING" id="86049.A0A1C1CI82"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04199"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08379"/>
    <dbReference type="eggNOG" id="KOG0815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="315" mass="33879" checksum="356DB4B9A40E2EA0" modified="2016-11-02" version="1">MGGKSGTKAVYFDKLKGLLDEYKSIFIVSVDNVSSQQMHEIRSNLRGEAVVLMGKNTMVRRALKGFIADSPEYERLLPHVKGNVGFIFTNGDLKTTRDKILSNRVAAPARAGAVAPADVYVPAGNTGMEPGKTSFFQALGVPTKIARGTIEITTDLKLVEAGAKVGASEATLLNMLNISPFTYGMKVQQVYEEGNSFSPDVLDIEESQLLKALTSAITTITTISLAANYPTLPSIIHSLINGYKKVISAAIEIDYEWDEIHELKDRIANPDAYAAAAPAAAAATTEEAAPAAAKEEEKEEEKEESEDEGFGGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIS0</accession>
    <name>A0A1C1CIS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">40S ribosomal protein S10-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rps10a</name>
        <name evidence="8" type="ORF">CLCR_04278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIS0"/>
    <dbReference type="STRING" id="86049.A0A1C1CIS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04278"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08540"/>
    <dbReference type="eggNOG" id="KOG3344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="7"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="169" mass="18992" checksum="AF56E23C9CB738EC" modified="2016-11-02" version="1">MSSRVLIPKADRKKIHEYIFREGVLVAKKDFNLPKHGDIDTKNLYVIKACQSLTSRGYLKTQFSWQYYYYTLTPEGLDYLREWLHLPAEIVPATHIKQQRSHAPPRGMMGGDDRGERRGGGRGGPRGDREGGYRRREDRGEGKEGGAPGEFAPTFRGGFGRGRGAPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJG3</accession>
    <name>A0A1C1CJG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04428"/>
    <dbReference type="OrthoDB" id="4508874at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="134" mass="14949" checksum="D26729228368AF11" modified="2016-11-02" version="1">MLYGASAWFCSQGGYGLKMREKYTIRRLAAIQHRANTAASGAFRTTAVGALCIELCSKPIAQRLTERVLQEGARIVTGPSYHTILQARVDHAHPARASPLEKLEKKLADRNLPPEQLETRTPYNLAPWEKPIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJI6</accession>
    <name>A0A1C1CJI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_04866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJI6"/>
    <dbReference type="STRING" id="86049.A0A1C1CJI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04866"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03219"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF12">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="444" mass="51241" checksum="E67D0A9B6B20D678" modified="2016-11-02" version="1">MQAREIARYGEMTTTHLGSKLWVVLNSNRLATEIYARKGAVTNGRPHYPIVSDLISQAKRSVLLPTAGWSERRRVMHQSLSGTAMTRYMGYQDEESRALLNHYLDQPALWYRHNHRYANSVIHRITFGERPDEKDDKIGDVTQAQFQFLMNAPPLNFWDCFPELSRLPTFLQFWRKRYEEIGQFTYNAYHAYWNPIKEKIQAGQAPPSFAKDVILGEGKFSGSDTDKMFLAMQITEAGSDTTRLAINMFILAAVTHRDKYLKARAELDAICGSNAQRLPSFGDEGAAPYLHACIKEIFRWRRIFIWTPEHELTQDLEFEGYFFPKGTNFVINHTNITTNPDLVESPEKFMPERWLDGNEQDILNGIWQFGAGRRVCVGYKLAQNSLFINLARLIYCFDFKAREPFDDKDINHFTLSEPFPVVPTVRSPAFAELIRQAAVRSNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJL7</accession>
    <name>A0A1C1CJL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJL7"/>
    <dbReference type="STRING" id="86049.A0A1C1CJL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05296"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03188"/>
    <dbReference type="OrthoDB" id="10463746at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="86" mass="8980" checksum="58BB05B7E030EC91" modified="2016-11-02" version="1">MSDLSADAPGGAGDGTNKSLDGRSSLSRDANGATSPLLPRHSSQASPPTDQPKKKRKVNHGQSLLRKRSVCAETDTSQHASIADVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJU4</accession>
    <name>A0A1C1CJU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LCCL domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_04668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJU4"/>
    <dbReference type="STRING" id="86049.A0A1C1CJU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04668"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03114"/>
    <dbReference type="eggNOG" id="ENOG502QUEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="182"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="654" mass="71861" checksum="1D5D604186248C60" modified="2016-11-02" version="1">MRNGAANLSPLPRPPQSNPQHSLRTSEHEDYPLGPMVADTALAAPSYEALLTSAGAGQYDEEEGADLVASSRGDQPLLSGRRISWRSGNRLQPSKSAFQAVLRWLNGPNPPRIYRIQSSEWLQAVCDRPLEKCCPSGGLKLCLLLLLYAIWAGMFILALPRSVAGSNDSGRPARLSCTSRLWSNSTNCGLDGADCRPFDHANFTFTCPAGCADVKILEPHYVGAQEVNYRSFVIGGPKDTGIPTTAVYRGDSFICPAAIHAGLVTNAKGGSGTLSRRGQQSDFPSISAHGVSSIGFPSNFPLSFSFGAPGPDTFSYSDSRWTYLCFSIILTSLLAIFITSPTTLFWSVFVGLFFHVAWISDPPYYHDYSDLISLAFRRFLPAAFVAHVIYKYCIHRTLYDLKAPIERTVLWLGGCWLGALNNVTFDRIPISRLTPHDLKQQPGAIAALLSIIGVLLVIAVGQAWCFRVEGRMPRYLLFYAIVAAFLVALILVPGTNLRIHHYILALILLPGTSLQTRPSLLYQGILIGLFINGIARWGFDSILQTPGQLLQDGELGSVLPQVHPPIVSGNRIRFTFEDVVASFDGISVLVNDVQRFVAFEPDDMSFNWTRLVDNEPEFFRFGYVNHLQLGGEWYADFTAPGQWLSNGTYVPGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJV0</accession>
    <name>A0A1C1CJV0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05175"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03105"/>
    <dbReference type="OrthoDB" id="5144514at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650848" evidence="1">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="188" mass="20767" checksum="F9C0A6080F9C442F" modified="2016-11-02" version="1">MRAFSAITSSAITVMLFGLFKATYAFGTANVWQWCKNSDVYCATVKGCGPGTAPGQCPGVHWDKLEHGRNITVDFDGYPSGTGMTIMCTRDPNASPIRVTQLEWTWEQGQGKVYYDVSNVAGTPFVDEAFMLHSVDAKDPGKTLNRCFDAWCDKNDVSCNQVYEVWNDDEQAMRACYDGAILGLQLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJX4</accession>
    <name>A0A1C1CJX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJX4"/>
    <dbReference type="STRING" id="86049.A0A1C1CJX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04737"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03151"/>
    <dbReference type="eggNOG" id="ENOG502T472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4159993at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="585" mass="61114" checksum="E5F2C80CC74748BA" modified="2016-11-02" version="1">MLRHGLGLHRRGPQAGDVLPSRIDNPTADLPPSIGPTDVATADPSATAPIVTAEAVSGFTTITETQTLAKSTDTGETTFTTEVTKTITNSAEYASITSVAAAASSSSTTRTTTSTTPAAATSSAAAKQSNSNLSTLIPAIVVPVAVILLASLAVFWFFMRRRHRRELQSQPEFVMTGKGEKLNSRSSSSRSTTSNPGPSEKKSPVVFQNELPSAISPPTTTSEWPPTQIGGVRPQTPQGPGSAGHDRVLEQQRTLTANSPYRNFRGPGQGLPVHGPRPATAGRPGPPASGRDQGRNRNRSNSTPGQRGQPPPPRSGLSPVSRMAPSPVLRSGPSPVPLQTSPTHSPLPSSSAFRFRDPSPTMNLSNRAQAPSRLAAPPPGAFNGASSISQYSPIVKDTPTIPKVLAGKRAPPPINTADLRETTRSPGSNSPAGHGLTEENMRIARLANSSRLGHTPAEPSPSPKLPPPATRSQLIPRESPKEHQDRFFGGGGNSQSAGPKTAASSHYASKRASVVSDADEYEDIDAKSDVSSLNEFERFDFGTGIGIGSGRGSPAGNSLTYFAATNSPASERGSAFGTTGVHERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJY6</accession>
    <name>A0A1C1CJY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJY6"/>
    <dbReference type="STRING" id="86049.A0A1C1CJY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04972"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03150"/>
    <dbReference type="eggNOG" id="ENOG502SI2P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5352400at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="349" mass="38828" checksum="46782561A42DA600" modified="2016-11-02" version="1">MKTSKAPKFFLSRRWKPNKWPFYVLLGIELPLTVALLALFGIAAPNTYRTRLWQDGADNGFNSSPTTGLYAAANYRPYTTPRVWSQFITDYNVVIAVLSMFIMLVKSVMYMLHVFPPVLAVLVHTGLLVLYAVSIDYQASSDTTDPEHPQHGAPWYITKNCNVAHNKDNIQYCEQAKASFACTCAMLGLFAVYFGLALYSCFPNKQQREEYAEKQRAKAERWAKFETYQDAETGETTVARFPVPETPGLQAKNPMTPRTMAFNTLGGTKDLPLRSHFSSPNAPVAPAAPSLDTRSPEIPRSPMSPGFLSRVGLGTDKSNGKSPEVEHFSPQNGATPQLYFPPPPKTSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK13</accession>
    <name>A0A1C1CK13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar ATPase assembly integral membrane protein vma-21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_05205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">COPII-coated vesicle membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VMA21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK13"/>
    <dbReference type="STRING" id="86049.A0A1C1CK13"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05205"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03093"/>
    <dbReference type="eggNOG" id="ENOG502SBNA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03058">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="108" mass="11587" checksum="E22C1A18444392FC" modified="2016-11-02" version="1">MATRRNVPEKTISEAQGGPPTSSQLSDTAPAVPASVVYKLLGFTVAMIIVPIGSYFLSLNTVFAGNATYSGAFAAIMANVVLFAYIIVAMREDQTDKIEAEEKWKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKN5</accession>
    <name>A0A1C1CKN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKN5"/>
    <dbReference type="STRING" id="86049.A0A1C1CKN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05110"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02846"/>
    <dbReference type="eggNOG" id="ENOG502SCIW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03445)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="261" mass="28124" checksum="688883CAD3AEAD5D" modified="2016-11-02" version="1">MTKLLVLVGTGPGIGLSTATLFASKGFDVALLSRNAARLEEDAQKVGAAGQGKVKVMSFPVDVSDHVGLKKTLGEVEQHMGKPEVVVFNAARIAQTVIGETSEEDLIGDFKVSQRSRARPTLTKAKLMNIGQYVAASWALPLLEDVAEEPDTHPSFFLTSSGVSYDPIPFMLSLSMMKAAQNNFLASLAKVAGPEGVHVGRIDINGVVSDEEEVRNAKHIAEQLWELYQQDKDNWSFVEDCGDMDGLLKAVGVESKRVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLA9</accession>
    <name>A0A1C1CLA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLA9"/>
    <dbReference type="STRING" id="86049.A0A1C1CLA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05291"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02650"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="93" mass="10659" checksum="457B9F3BFCBB0A5D" modified="2016-11-02" version="1">MNAICPNVIRTNISTGAFYDTLEKENLLAPIEGVVDTFEKLLDEQTSGEIFEISPNYKDQGAVVRKAPEYLDKESERTFELLYQRGRPLHQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLF5</accession>
    <name>A0A1C1CLF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLF5"/>
    <dbReference type="STRING" id="86049.A0A1C1CLF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11310"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02608"/>
    <dbReference type="OrthoDB" id="4159530at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="1">
        <location>
            <begin position="60"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="556" mass="63127" checksum="1845B7EA5817307F" modified="2016-11-02" version="1">MDDYFDITEDALVLSNGLPHDIVPDLVADTYQEASFVNAHENLGAHQLPPRQRRSTIADTVWDTLKPIIEELYIHQGLPLTDVMARMKQQYGFDASDKMYKKRFRDWHMRKNSTQALKQEFISKITQQNIAPDPSPLLDPNGKPLQAQRLLRKVQRKGARVSLVDRQACTMLQRKHLLSARVDNVCHVQLQQSCEAQHTENILRSARTYYSWYSTQNSIKVQYGLSAALSHFMQDITNAVVSLRTNSVRRGFALLNRCCSGLVVLLKEQPFQLLQRLIHCFAVKTGLWGSYCDVQRTLLKIMASSADVILGTTHPITTLMASLTAMRQEHMRDLACRYAELLADTTMILPDAQDSTELLGSVAEIYLRHGQLDNALKLCQSLWDAAQPISSPPSAGQLYLLLLTAGLAQERKDYGRAEQVLRLGIGRDVQDTGKRVGNVNGIRLCYEMARLYADIGRFAESERFYRTVIESVTQWERHAAVSLVLCSIRLGRVLEKQGKVEESALLREPYDQTWAELEPWELRHDPDELPPDDEVAERDGNAMYHCYGNLTQRSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLT7</accession>
    <name>A0A1C1CLT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_04923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLT7"/>
    <dbReference type="STRING" id="86049.A0A1C1CLT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04923"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01754"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT49470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="48095" checksum="129C879221D5E26A" modified="2016-11-02" version="1">MKTIYDRDAIKTSFYKGSGRYKGVQQILGTLDYKTAAPARANLLQCFQNKNLESLSDVMESHINTFIRLLYQRSEQDQMVFDGVLWLRLLTLDTVTDILWGDQHNLLTNLGDQSSGLLVKFHSFSKFAALKGFIPGFEFYARFLGSEKYRSLRREAYDLDSYARSALQKWQAGEKKGHTRDVLSMLMSMNSLQDPSHRIAPEHMPAYMVEMMSAGSSTTSNTATIAFWLLARNKEIQKRLRQELFETFPDPDKIDMKQCLGLKYLDCVVLEIMRLWPILPGPLYRHLGSPITVNGLTVPKGVIASTSAWDQHMRPDIYPEPESFKPSRWYETTDAMKKNWIPFGYGSRSCPGQNLGMTEMKYFLAAVLRHFESVIPEGKEKNVIEMRDLFTAHMWEQDGESGAWGPQVWLKFVPKPHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM81</accession>
    <name>A0A1C1CM81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_06914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM81"/>
    <dbReference type="STRING" id="86049.A0A1C1CM81"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06914"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09900"/>
    <dbReference type="eggNOG" id="KOG3847">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT49655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="605" mass="68686" checksum="F962FDBB02B9F12C" modified="2016-11-02" version="1">MPAESIFPDFVLGHPRHQKNKVKDVPSRKKPKGRPPKGLRDRVPFYGRLPHYTGPYEVGVIDFEVPAKNPRTFSDITRHGVHVLALETVLMTIYYPAHLNARYDIHTPTSGQRHRPTWLSRPRDQTSRGYAYFAGLPAYLMIAWFFCTTWFTKLPAYKNARLAEHWPPYGEGRTNHRKPAANEGDPPTTGPAKPKFPLIIFSHGLGGTRTCYSSVCGEFASHGFVVVALEHRDGSGPRTLVTHTDAGPASRHCTKAKGGVEHGSSDMKRSYDKVDFIFPKHDTHDTSPGHQIDQELRNAQVDLRLAEIDEAYQIMLEICAGDGEKVAARNIRVNGAIGASRAGLKGVDWSGWRERFHTNGVTMVGHSFGATTTVEVLRQKQRFSYITQGIIYDVWGMPIRPTAEERDSRIRVPLLGINSEAFMYWKDNFDVAKKVTMEALETGHPAWLMTVRGTVHISQSDFCILYPHLASWLMKMTIDPIRAIDLNIDASLEFLSRVMPKDVQHEQPFLRRLTKRKLLDSQVLTDLPTEHAPDENYTAVRLKIEHETRTRLTPGGKKKYWDEIRKSEEGETWLHISPDSTPDMARCQTCALPRWDDVERPTKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMI5</accession>
    <name>A0A1C1CMI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_07469</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMI5"/>
    <dbReference type="STRING" id="86049.A0A1C1CMI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07469"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09959"/>
    <dbReference type="OrthoDB" id="4540858at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28222" checksum="05B67271F8899C8F" modified="2016-11-02" version="1">MVLFTQRHEVHQRADYLVKEQEQQAGKSAVMDIVDRDMERAEVQATRQWSHESKERRSLRSQRSQRSIGSSSSASSTDSTPDMDRIATAGASSANMPSYRAARTRTHPIEDLRTETHRLQHIQTVGASVKSKTDTRSLPEFGGGKPYPPDLPPQEAYVVEFDGKDDPLHPQNWPFRRKFYMGAILAYVCLCSTFTSSIFSASTFSVAAHFGVSAEVATLSTSLYVLGYAFGPLIWGPFSELQGTGARVRREEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMP6</accession>
    <name>A0A1C1CMP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07657"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08700"/>
    <dbReference type="OrthoDB" id="4138962at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="184" mass="20068" checksum="4A4A06CFDD8225BF" modified="2016-11-02" version="1">MALSNGNSLFVATELPCDPSDNCAQSPVARVDGNIGKAGFAILVPPPDPVSKNVSHESFDVVNHAPYDGNFQDSFEHTSLHLSSTDYSVPFATEHKSFRDVEAYFQEAVVSVLDRSEWIADLDVLKSLVSIKQYSNVVKGSQHVSAECRLYNPFDEAGINLTSVDTWEELIDRPPGAAVVRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMW1</accession>
    <name>A0A1C1CMW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GSP1</name>
        <name evidence="9" type="ORF">CLCR_07484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMW1"/>
    <dbReference type="STRING" id="86049.A0A1C1CMW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07484"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08760"/>
    <dbReference type="eggNOG" id="KOG0096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT49837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="217" mass="24362" checksum="2F77B4C7996FAB96" modified="2016-11-02" version="1">MAEAAGGVPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPLGFSTNLGQIQFDVWDTAGQEKFGGLRDGYYINGQCGIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNPQLEFVAAPALAPPEVQIDQAQLDQYHKEMTEAAAMPLPDEEDPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMZ4</accession>
    <name>A0A1C1CMZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMZ4"/>
    <dbReference type="STRING" id="86049.A0A1C1CMZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07796"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08735"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9155" checksum="38B669FE33B5193A" modified="2016-11-02" version="1">MATKRKIGAITDTQDDDPVDPSDELVFTGLGGCQEVGRSCHILQYKGKTVMLDAGMHTGREGMSAMPYFDDFDLSTVDILLISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN84</accession>
    <name>A0A1C1CN84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_07029</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN84"/>
    <dbReference type="STRING" id="86049.A0A1C1CN84"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07029"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08858"/>
    <dbReference type="eggNOG" id="ENOG502SNAH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="43"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT49943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="504" mass="56959" checksum="DE6EA0B18BB2F478" modified="2016-11-02" version="1">MVDTLHLIATWPKPNYVDPDTRGPGLIYVCIVFGAIGIITGLARLYSRLFITKAPGLDDLLVMVALGFLTALTVLVIIGNKDFYSGRHVWDIPPSSFVGGRINIWASLWCYVIGITLIKISVLLFYRRLSVKFSKAFLIATWIGIIYNILYFVSFGLTLLLLCRPLHAYWDSFNPVWAATHHFHCASENAALPASSAFSVAGDFYSTLLPLILVYYLELPRRQKFALYALFALGFMAVAAGVVRTVLMYQLLNVEYDFTWELWLTWVWAVVELYLALFAASAPSLKPFFQHFFVDSISSFARSSRRRRDYGQTSGPGHELPAKDVEQGMYGTEGQHQHQHKQHPSRPRPDVDRGTNRLTWITRDERSVSQQSWFRGDTSTTGGDGTRHLELRPTEDGKKMIPMRVYGRDGRGGVAESEYSSSGASGATANPFSDTDTDTNTVREALDRDRDRDRDRERSDSNLTMTALPQSRHDWPLPGLGSEPQHQPREFLANPRLSMYDRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNA2</accession>
    <name>A0A1C1CNA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative pentachlorophenol 4-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_07016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNA2"/>
    <dbReference type="STRING" id="86049.A0A1C1CNA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07016"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08913"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2096480at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="544" mass="59499" checksum="37CB8B6CFD698ED0" modified="2016-11-02" version="1">MNTFYDVIVAGAGPVGLFLACELAVAGVSVLVLEQQESPESPWKVGLHGTRGLHIHSIEAFYRRGLLDKVLHNIDVPGHVAKVPGYDLNFAAHFASIRLDPKNADFARWKYHLPLPQPAEAKLFYPAPTSVDTLEKTLAERAESLGVRILRGVEFTDFTEESETVTVLARDHTFTAKWLVGCDGERSKVREAAQFEFPGTPAEFRGYVVHCDLANPEVLQRGFCRTAAGMYIFPAPGHLYVTDFETLGLKGGDEAITREHFESVLRRVSQTEIVVTELHRAMSMTTHLKQTTTYRKGRVLLAGDSAHVHPSFGAQGLSIGIGDAMNLGWKLAATVRGIASPELLDSYNQERHPEGARQLEWARVQLSLLRSNPYSLATAKLMKDLIATKDGNTFFIEHIVGLAKLYNLGNAHPAIGYSAPDFELADGSRLGAKMRQAPFLVVDFTDNHAVANYVQSLGSAVTYSGSQPKDAIDLKALIVRPDGVIAWASADKIELTELKTELGRWLDLSKLETDATAALMTRMTLKNEAEVSVTAIPIAATVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNC8</accession>
    <name>A0A1C1CNC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNC8"/>
    <dbReference type="STRING" id="86049.A0A1C1CNC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06840"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08907"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF315">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE MDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="56"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="524" mass="58262" checksum="46797E539B275259" modified="2016-11-02" version="1">MPSAIETTNGVHDGEMEHKNGLHKNGLLGHSNGTTKDLSYAEIAGEVDRYPDSGITVLIVGCGPGGLMSALECWRKGCTVQLIDRAYAPVNTGDVFCLQPSCMSVYRHWPRMSKEIEEEQYDAGISYWHNTGDRIYGPGPPEFNDAEALEGRKGPRVGFMQGRIKFFNMLLRQVKRCGIPVTWGRRVVEYYEDEAAGLGGVVLESGEKLDADVVIAADGIKTNSGKLIAGYTPEPKDSGQSIYRAGYSPDFTKDDREVLERWPTKQGDVPEWQFWLGAGLHLSAMVSNDMIVWGLTHKDEYAPDGTESWNASVEPEEVVGLMERVAPGWHPAVSALLKTTPRGSLVHWKLRWRDLLQEWTSPGGRIVQVGDSAHSFLPASGNGATQALEDAISLASCLHVAGRNNVAIATKVHNRLRYERVSCAQKMSFVNTQQHHFTDWNAIAENPKLIRTRFPSWVWKHDPEEYAYKKYGEGFLHVISHGKSPLQNTNYPPGHTHKPWTVEQVRMDLLNNVNIGAGLDGDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNP3</accession>
    <name>A0A1C1CNP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_07011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNP3"/>
    <dbReference type="STRING" id="86049.A0A1C1CNP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07011"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09035"/>
    <dbReference type="eggNOG" id="KOG2370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="5">
        <location>
            <begin position="55"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="4">
        <location>
            <begin position="412"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="546" mass="63509" checksum="6F1409DE63454267" modified="2016-11-02" version="1">MSDGEYPSKRRRSQSPPRRKYDGDRQYRDRNAPNRRENGQPQRWSHKDQMRINQMQEDERMREWVAQEDDFVLKQAKKKADIRVKEGRAKPIDWLAVTLRVVDPTRNPLDDEVDEKDLDFVDPDSVFDDLSESQLTELRKDIETYMSLEKNRKNRDYWKTMQIICKDRQKKMRASGPEGRAVSSVAADIDKLLGPKTYEQLESLEGQIRAKLDSDEPIDTDYWQQLLDSLLVWKAKAKLKRVYRDVLDSRLKSLRQENERRATLAQQHFRSAGVETTGSVQYSKDLDPEPLLEIAAKDKSLEVQDESTFLQSVAASRRKVLHMGYVPAPKLNAAASTPSFSAQPRPSSQQTKPTDPTARFDTSSHDDSSSTKALFDREVARGVNDDEEIFANEDESATSPQQPAWLSQYGGKYRPRKPRYFNRVQMGYEWNKYNQTHYDHDNPPPKVVQGYKFHIFYPDLIDPTKAPTYKIIREGGRRKGQTMAPAGEEDTCIIRFMSGPPYEDIAFRIVDRDWDYSAKHERGFKSTFEKGVLTLHFSFKRIVYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNQ7</accession>
    <name>A0A1C1CNQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 28 member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SLC28A3</name>
        <name evidence="12" type="ORF">CLCR_06721</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNQ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CNQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06721"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09048"/>
    <dbReference type="eggNOG" id="KOG3747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="621"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="277"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="359"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="462"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT50137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="691" mass="76062" checksum="A0FD1692A54EB951" modified="2016-11-02" version="1">MSSNPDSIDPKDTRGVQDDGVHAAHPIDAPAQGGERRRTHHDLPDHGHNLSLQKSVDENPDLSLRYSHEHQHQHLHHGRTSLSGKRDEVLYAEGTTADNHMAFVNNNPQDYLKHQLRKPSEQINEKDFSNSDDAEKGTVDPTRVMTNGSDDGQKHRISRSYAKYKIFVHIFIWLFFTGWWIAGLVLHRTDNLGWLKPFLLWLAITLRLIFFWVPITVVTRPMHWAWNNTGVRVYQAIPEKLRIWLAALVALATILVGSFVSAESADNTRGNRAISLLGLAVMIAVLWITSRDRRKIRWHTVIGGMLTQFVIAVFVLRTKAGYDIFNFISFLARALLGFADQGTSFLTADSVIDLHWFLTGVVPPIIFFVALVQVLYYLGILQWFIGKFAVFFFWSLRVSGAEAVVAAASPFIGQGESAMLIRPFVPHLTLAEIHQVMCSGFATIAGSVLVAYIGLGLNPQALVSSCIMSIPASLAVSKMRYPETEETITSGRVVIPDDDEHRATNALHAFANGAWLGIKIAGMIVATLLCIIALIGLINGLLGWWGRYINITQDGEAYLTLQLILGYICYPVAFLLGVPRGDLLQVGQLIGIKVVANEFVAYNSLTSEAQYINMSPRSRLIATYALCGFGNFGSLGTQIGVLSQIAPSRAGDVSRVALSALFSGVLSTLTSASIAGMLVTDQVTLSQETGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNX6</accession>
    <name>A0A1C1CNX6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sterol desaturase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_07384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNX6"/>
    <dbReference type="STRING" id="86049.A0A1C1CNX6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07384"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05778"/>
    <dbReference type="eggNOG" id="KOG0873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="156"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="343" mass="38581" checksum="D21AEA60ECF33CDE" modified="2016-11-02" version="1">MTDAIIGLPMLSFLLIPTMSSYSTSLNLLFFYLTWSTLVLSHPPLKVEIIASLAVRLLFYVFPSLFFLAFDAFVPSAAENFKALGDSALPLKNASRKRTIALLRMVGWSIFNTLLGLTIQAGVEIVFTRVLLWRSALRVTTTLPLPWGIIKDLAKGYLLREIIAYTLHRCVLHNWNHTVSLSRSHRDWYHAIDAPFPLSATYDHPLAYLVRSFLPMYLPALILRFHLLTYIFYLTLTSLEETFAYSGYSTMPTNFILGGMARRTDNHVLCDGEGNFGPWGLCDWIMGTSVGADLVDDVVAEADKHDVPGKVEKAKGRVRKGVSQEANGMKGAMKRRTRRRADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPR5</accession>
    <name>A0A1C1CPR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07159"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05543"/>
    <dbReference type="OrthoDB" id="4160759at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="411" mass="45654" checksum="2F591E98F8E5EC46" modified="2016-11-02" version="1">MAEEMNPGAQPTDNQTGRRESGIFKQDAASDVKFYKMAYQDPQFSAFQENDVFEHENGQRIKLVYHNVKIQGRQDRSIRPYNPPRESLGFQLANEEVDSSNGPSNLSLATGPKEMELLVGGKREGDSADPWRNWKLLRPKPSSDPNGPAEFETLGTLNDVRANWNNRWPTRPVPNEGDAAGPDDQSDEDQARGKNTKVRKRRSTQGQGQRTSARAGSLSGTVGSRHSQSLQRTSTQAQASAFHGPLLGGDTRGPLLAQEQQYGSQLTYNTPQNYPPVIPQFDPQNAQQYTQQYGGDAAFQQSTYTSERRPMAPPLLRSSRSQLQELPHDMQQTPSSLFAASSSYGVGGGDLSGSQMPQQPRSTFAQQTPAQQSLYQQQPQSWNTKEQAYKQQQPGSSNDMGEEANDEHTFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPS3</accession>
    <name>A0A1C1CPS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">High osmolarity sensitivity protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hos3</name>
        <name evidence="2" type="ORF">CLCR_07799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPS3"/>
    <dbReference type="STRING" id="86049.A0A1C1CPS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07799"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05509"/>
    <dbReference type="eggNOG" id="ENOG502SGDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3358869at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042332">
        <property type="entry name" value="Hsk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="99" mass="10617" checksum="D22E55A8B3C517FD" modified="2016-11-02" version="1">MDRNTTSTKPSLPRPSSVASSNAASTNKNRQYAHLHAQLAQLNAHLADTENLLRMTAVQAQDMRFLGGYVGALFMGSAKVLGEESVQGRGNQAAEDKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR77</accession>
    <name>A0A1C1CR77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_08819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR77"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08819"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09623"/>
    <dbReference type="OrthoDB" id="4127560at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="347" mass="38493" checksum="4348CB9797909FBC" modified="2016-11-02" version="1">MAEYLEAHNLPDTIESEDAVEELLSRPPIWLPRLLQSVEGDIMFLGIGGKVGPTIARMAKRATPSKRVIGVARFSEAGLRERLESWGLETVTCDLLNREAVASLPDVANIVYMAGKKFGADEDPSFAWAMNTHVPAVVAERFKASRIVVFSTLCVYSFAPISGGGWDESVQPSPAGDYAMSCVGRERMFSYFSRRHNTPGRIIRLNYAIDMRYGVLHDIARWVKSGTPIPIETAYASVIWQGDSNAQILGALAHVTTPTSPLNVGGAEHMSVRMAAHEFGRRFGKTPIFEGTESEYGWYNSTLAAQRLYGYPVVSLARMIDWTADWVGKDKPTINKPTHYEERRGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRC8</accession>
    <name>A0A1C1CRC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_08012</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRC8"/>
    <dbReference type="STRING" id="86049.A0A1C1CRC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08012"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09698"/>
    <dbReference type="OrthoDB" id="343623at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001499">
        <property type="entry name" value="Origin recognition complex subunit 4, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032705">
        <property type="entry name" value="ORC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14629">
        <property type="entry name" value="ORC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="7">
        <location>
            <begin position="386"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 4 C-terminal" evidence="8">
        <location>
            <begin position="593"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT51064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="840" mass="92151" checksum="E15C49AE2D3D1387" modified="2016-11-02" version="1">MQHEPLATVASGNWDVVVDNTCSQVSISSSALSAAGPTRMDDLDPSHRGLKRKRTGSYATRRRTLASSPAQAQGPQPVTTKGATEAEVAEQVVDESDDPTTHFPAVEEPLALESDEQARTPTSRRSSGGRQTSEDRSSDIKASAGTAGRPRGPRKSQNGAKQTARPRDTEEEQPVPVGRRSSGRTRRPARRAGSAVDKLPEQTPSTSLVKNRTATGVLSPQPKGILTPSRRGRGRRNGPRKSVVFHEDVDVDDTDEKQIEDHFGFKDISSSRKKNGSPSTRSISESSRAREEDVFEDATEYQDRARQHGAIGDADDDSISDEYPDTDEIAPTFQPTSKMAQAHSSLMEDENPHLTNIKVQVLSRLISRSQTPDDPARAIPAHLHHQYTTLHSLLSATVTAGESNSLLLLGSRGSGKSFLLENALADLSKSHSDDFHVVRLNGFFQTDDKLALKEIWHQLGREMAVPEDETSEVSSYADTMASLLSLLSHPEELGHSDAMEVDGAYNSREHGPARTSKSVIFIMDEFDRFTTHPRQTLLYNLFDIAQAKKAPIAVIGCSTRMDVVDCLEKRVKSRFSHRWLHIPAVKSLMAFEEIAKDVLCLPVEGKDVLGVAKEERDWRARWKEIIETQFLPSSGVQSMLKTTFSSTKSITDLLAALYVPVATLAVPDNLADQPQAPPPSIMDNTTTTTALPSLLALLPHLPILHLSLLVSAARLETIYDVMIINFTLVHKQYADLLARSRLQRSSLLSFNKAGTLTGACLRTWNKDTARSAWEELALWEFIVPASGGGGRLGDEGLGGDGIVTRMFRVDVTLDEVAWAIKQKLGLTGVGETLYKWCREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRL3</accession>
    <name>A0A1C1CRL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SRB8</name>
        <name evidence="14" type="ORF">CLCR_07891</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRL3"/>
    <dbReference type="STRING" id="86049.A0A1C1CRL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07891"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06930"/>
    <dbReference type="eggNOG" id="KOG4522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057344">
        <property type="entry name" value="ARM_SRB8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25326">
        <property type="entry name" value="ARM_SRB8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="13">
        <location>
            <begin position="257"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1295"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1310"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1327"/>
            <end position="1336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT51140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1514" mass="167961" checksum="94BACC466E2F8A78" modified="2016-11-02" version="1">MTSIPLAEPRPPPQLPRPPGLSRPPARRSTSNVFSPLDRRPSGLQRQMSDIGDDRPAKRRKMEGEGQLLEQASSHNTITPVLTQPADSEGGDRTVQLRWVKPSAIRLRAGNSLRKDEESGEGEDDVPELPPRPWRAIQASHAMEEPKPTHRSRVNIPVPNTPDSIELPSAVPHFVPRKPAGFFPWTGKHAEDILSDTNVKTGYFDKPPTPTEKELNTARVPLYNAFKHKSGVDSLSVLFSLVLDQKSLHGTTSSVSTFKPPPRVTLTEAKRKSWIADLANADVPLRRLSRTIPQGIRGQALLDQCLQSDVPLSRAIWFAKCVCANEIRTLKRKGTTPTVAVGTETKWLREWTVNVEQFLEAHLARSSLPDWKSNIQYALRLTTRLYLENLLDRDHYLDWILRSLASADVGHTPFWLMVTHIYKQDLSQYRRKGSRLVEVLINKFRSLDKAQEPTMAPLRQKLRAAIRELLFARSALFLMPDKWPERMEIIRACLDPTLPPERQLFEGLNRINKRAMGYNKADISSIRAPDQAIVDILDAARVPYNLAALEDTLKTACSDFALLMQTCLEWSCTRFRCSRTRIYLITRLVKRWQREGLDVDTALLSFLSAYRERRTTADAENLRHLIAQLSRSDCFNISKYLQWLMVRGLPKHGMVDIDPYSTSGSAAGTWQEEDPEATHFLLDLSLDKADDHVVNLRRAMLERAGFDLNSEEAAFRQCIRFIEQGLAGPNSASNSPSPSVTEPAFDSLPWTLRTRVSKWLRARALEGAKAEETGPALPGSRVLNEGQFFLIRHILESMDDEAVLADVVGILSASKNDDLVASLVATIHFHADAFSSIGALELLQKQMCQVYMTWRPAKPTMPLLTSTLLDLCTAFPSKTPAIKLLQQDLVRGDRGRAVAACSPYSDGIAESLQQAGATFVEDFEAILQSETNMNEQTMNGLFSVLVDRIEKQQKFGDDPQTTLSFCQLLSRLRLCRKGQGDRLIQKWMSRVLPRLDSKWGPLLLRSLVSTGCLSFNALLEAVVTSKHGTRRNVAFASLLYQMLGSTKGTAPDWAAYQTRTRWYEYVQREPKAALEVLCEAGLQGFSPKFDALLLSLLVNGSTSSSFVLSGAVRQWFLKTLSRSLNCRDGELTGTDLRALFQTMNIFSHPYVQLRVRSTPESTAEKGSGVNHDELADVLHTSLQNTMQISPRSSGKGQDRRFAQFLQTVGPEVASSIRHKVENEFLEASPKLPLGKATSPLAAAFPGEVQQLGSIVERAFQVCRKDTVPSAGFLSQLIDRLSQFFKSLAYASVAPSTPVTTGHPAIPGLSGPTTATSSPQMVPAPATPTMSASENGPSACSVPCLSYLKYMLQMVCLQRPALILAGVSGPNSKQGQSEQVQLLVRLASIATHPAMAAASKQPGSEERQALAKDVILSMFDIIATIVDEVSDEVNMMCAKLLKDKLQDGRVRYLFGSINMLGSVQVQDMGQGLQLTKEGKGVIGEWRPRMWEVLNNGSGKETETSLGLGLFGARYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS11</accession>
    <name>A0A1C1CS11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RPT6</name>
        <name evidence="12" type="ORF">CLCR_08667</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS11"/>
    <dbReference type="STRING" id="86049.A0A1C1CS11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08667"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06809"/>
    <dbReference type="eggNOG" id="KOG0728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000068">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="165"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT51273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="389" mass="43350" checksum="EB684DEAD50E81B4" modified="2016-11-02" version="1">MALDNFYHNKIESLKLEIIQGQAVLRRLEAQRNDYNSRVRLLREELGLLQQPGSYVGEVVKVMGTKKVLVKVHPEGKYVVDIADSVDISKLTVGKRVSLLSDSYKLEKMLPSSVDPLVSLMMVEKVPDSTYDMIGGLDQQIKEIKEVIELGLNHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHADCKFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRVEGSSGGDSEVQRTMLELLNQLDGFEPTKNIKVIMATNRLDILDPALLRPGRIDRKIEFPPPTVEARADILRIHSRSMNLTRGIDLKKIAEKMNGCSGAELKGVCTEAGMFALRERRVHVTQEDFDLATAKVLNKHDDKEVSLGKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSG2</accession>
    <name>A0A1C1CSG2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_08516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSG2"/>
    <dbReference type="STRING" id="86049.A0A1C1CSG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08516"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06661"/>
    <dbReference type="eggNOG" id="ENOG502S5MV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="360"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="445" mass="49477" checksum="6F40395F70897944" modified="2016-11-02" version="1">MASLFSSRRKPKRIARDESEDQADDGEEDTGPVVRRPNASAPRTKSKLRVSFNPTEDDGSGTGRETGTGASTPTETALPRPTKPSRIDLAQDIISRRERDQESPDRSRTLYNKAYLDELRNSTPSTPRDISSPQATPSTDLIQPSSHLELDLESKFGKSVLSTASSHIPSAAEIKEKKDRRARLAKEQAANAYLGHTHGGGSAGDDFISLEDYDSDGEFRPHRMQVGPSISQAREKDTRLVHEDEDIAEGFDEYVEDPGRVTLSKRGLKEQSRQEREAIRNMIDQAEGSASEASDNDNTDASDSDYERRKEYELAQTHHGMDGLRWHSSRTAQLSRPQQPRETTPVPKLSVGLSRLKDMLSALEFEKARIVKRKADIERERADIKASQEHIQRSLEEAGQELERVKREHADRVNGTNGEVNGHGLDANAAGTERERGLESFGDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSS9</accession>
    <name>A0A1C1CSS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sodium/potassium-transporting ATPase subunit alpha-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_07933</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSS9"/>
    <dbReference type="STRING" id="86049.A0A1C1CSS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07933"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06572"/>
    <dbReference type="eggNOG" id="KOG0203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="893"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="922"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="971"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1028"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1067"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1100"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="124"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT51517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1135" mass="123840" checksum="325A88F2F21216B2" modified="2016-11-02" version="1">MVVVDVPQRSENPKVVDVVALPGPNDDDFPTALAARRRIRYAGDDEENPGPSSTNNFGHTLTRRTSTYSVHSLSSVRSGQRTIDPSIILPVQYRTLSYDITNSKAIGKAKDAREKATVDVGRLEWHLITPAEICMRLKTSTETGLSSTVVKEKMTEFGRNIPSSPPSRLMQKLFGYFFGGFGSILLVGGVLVFLSWKPLGQPPAVANLALGIVLVAVFVIQAAFNAWQDFSSSRVMNSITGMLPEACHVLREGSKQTVQAPEIVPGDILYFKAGDKLPADVRFTDVSMDAKFDRSILTGESLPLGAVTESREPNYLETRCIGMQGTHCTSGSGVGIVVSTGDSTVFGHIAKLTSTPSTTRTTLQKEVLRFVVVIIGLMILMNIIVVAVWGGYIRQKHHDYINVPTLIVDIVSVAIAFVPEGLPIALTASLTITANTMRKNNILCKSLKTVETLGSVSVLLSDKTGTLTKNQMVVTDCLIGVSSMTALEAAEDVADDSAKSMSKKAALQQLRVVSAVCNAGEFDPTTVHLPLDQRKIIADATDQAILRFSQSLGPATQSRDMWRTRFDLAFNSKSKFALRVVSAECASAFSSTMAVSEASVFQADKDLLLMIKGAPDILLPRCTEYVGDDGGTYALDAVVRSSIEAVKDAWSSQGKRVLLLARKLLPAHIVRSAPNDNMFETEALKHASAGLTLISLVGIVDPPRDEVPSVIQSLRQAGIRTMMVTGDFKLTAQAIARACGIITVPDREVHTVDNLPHFAPSDPPEKKRQKKSNLLPSENKAIVLTGSDLMALLPHQWHALTTQYSEIVFSRTTPDQKLRIVREFQSEAFVVAMTGDGVNDAPSLKQADIGISPASGSDIAIEASDMVLLGSFSAIPEAVMYGRVVFDNLKKTIAYLLPAGSFSEFWPVMTSVVFGLPQVLSSFLMIVICCFTDCVAATMLAYEQPEANVMLRGPRDIHNDRLVDWRLLLQAYGLVGILETTCSFAMSFWYLQRKGLAFGTLWFSFGNLPTPPGQTADDVSSHLTEASSIYFVTLVVMQWFSVMALRTRHLSIFSHPPIFNRKTQNRLLFPAILFSLVVALVFTLSPGIDYLGCNNVPVEHWFIPMTFGIGLLSLDELRKMAVRRYPRGLLAKMAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CST8</accession>
    <name>A0A1C1CST8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_09280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CST8"/>
    <dbReference type="STRING" id="86049.A0A1C1CST8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09280"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06563"/>
    <dbReference type="OrthoDB" id="2014905at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_bL32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="124" mass="13010" checksum="18FB9CC1FEA6C492" modified="2016-11-02" version="1">MALAGPVPGGRLSGLVLGRSVATISTAIQAWSSRSLLSASIPLPAITVIIPGLVSDIWEGILKAVPKKKTSHSKKRHRQLAGKALKDVKAVNQCPGCGKPKRAHTLCPYCVAGSFNAPAMLKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTB8</accession>
    <name>A0A1C1CTB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_08069</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08069"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06366"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="612"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="614"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT51733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="665" mass="73334" checksum="60ADBB88FF1780A5" modified="2016-11-02" version="1">MQASLTSTVDLQVLQSQATRPSVSRRQSAQSANKSTTIACVACRRKKVKCDSRRPACSQCEEDGQPSCKYVEWKKTGLPRGYVRNLEAQIQALKAENDELRDLQGKTQGGNHLSHAQAAARYEFPSDDTVPSGFLDQTSPYTSSDHDILMQDPFDIARLAISELLTAEDQNSLCTIYFTRCHPFVPILHKPSFSVDKDAHVSLSVFALASRHNPSLASKSDIFYSLAKQTTQATFINPDMSTLNALILQAIYEIGMPNSSVHAVTTVGSALSLASAFKLLRMEDQEDGESKPNRWMDRPVDWIDEEGRRRAFLMVLSLSRWMALIQEREMGFPVKRDITVMLPISDEAWFADPASRPATRPVTEPITSLRHAFDAGPFARFVQALGLFAKVSDFNQTFRLRSSSENAEELSKIDNIIQAYLGSFPGSWRSAQLEGEYLLDPTTLALAHSALLLLHHPIARRESHGSSKIRCTAAAEEILDVAYGILDVPHTGNYLLPHPLVLAARVRLLELVQRKGHYRGRDMDLIVKALLTFGKYWGMQEKLTEHAGKIEANTVPFSEPLTHVIPVTKQPVSRQKTAQFVPSMPRRPAGSSIGWAWGSTLGGVGTVGDEQVSGGVQSPDNTNTSLCNPEPSPHTNPMDASIFSSDIFDWTMGLGSETLNGGPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTF5</accession>
    <name>A0A1C1CTF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dimethyl-sulfide monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dmoA</name>
        <name evidence="4" type="ORF">CLCR_08313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTF5"/>
    <dbReference type="STRING" id="86049.A0A1C1CTF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08313"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06335"/>
    <dbReference type="eggNOG" id="ENOG502QSR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF41">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_3G15040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="3">
        <location>
            <begin position="63"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="501" mass="55347" checksum="7C8223A5605C10C9" modified="2016-11-02" version="1">MSTTDAANAKINGATPHGEAGEASKGSVPGRKNLILNAFAMNTPGHLSPGLWRHPRNKTYNYKKLSFWTDLARLLDDAGFHALFLADVLGAYDVYKGPANTGPALGSGAQFPVNDPLYLVPAMAAVTKNLAFGITASTTYEPPYSLARRFSTVDHLSDGRVAWNIVTSYLDSAARNFGLDQQVEHDARYAMADEYMEVLYKLWEGSWREDAVVADFDTGVYAVGERVRDINHQGTHFRVPGPHICEPSPQRTPFLFQAGTSKSGRAFGAKHAEVIFAGAQLPEKLKPSVAAIRQLAREAGRDPYHVKIIASMCVIVAETDEAARHKHEEFLSYGNREGALALFGGWTGVDLSTYSDEEDFRFVKVPMIQSIVNGWADTVPGSENLKWNKNRIAEYLILGGMNAKIVGSPTTVADELERWVEIADVDGFNLSHVVNPGSFEDIIEFLLPELRKRGIFRDRVEKQGATAREQFFGTPSLLQDHPGSKFKWNKDEAVPRYQQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTW5</accession>
    <name>A0A1C1CTW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative NEFA-interacting nuclear protein NIP30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_09039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTW5"/>
    <dbReference type="STRING" id="86049.A0A1C1CTW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09039"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06181"/>
    <dbReference type="eggNOG" id="KOG4036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75807at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="220" mass="23827" checksum="E69779B38F93D61D" modified="2016-11-02" version="1">MSRFVSAGADADSRPPADDGWLRAQQEVQSSKEPRSTEEGKQEGGKSLYEVLQANKAAKQDAFEEAARLKNQFRALDEDEVDFLDSILETSRAKEDAVKQETAEQLDAFRKQRAAAEQAQIEDTLGGSPSGPTDGGSWATKKKKRRREKDGEPSDTKLRKLSTADGDRSVLPSSDPSCLAHSDPARPAKDSSVQVAPSKDELNQKSAGLGLAAYSSDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTY5</accession>
    <name>A0A1C1CTY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="1">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_08934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTY5"/>
    <dbReference type="STRING" id="86049.A0A1C1CTY5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08934"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06161"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="4"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="8">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT51968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="265" mass="29880" checksum="5B56B5586479017D" modified="2016-11-02" version="1">MNRYGTETGVAKGIKKSGIPRSDIFITTKLWNNSHHPDDVEKACDASLKDLQTDYLDLFLMHWPSPFARGDKLMPKKDDKIIPGDSDYVDTYRAMEKLVARGKCRAIGISNFSKAELERLLKETSIVPAAHQLEMHPYLSQPDFAAFHKSKGIHITQYSPFGNQNEIYDKGKNMGKLIDDPVLTDIGRKYGKSGAQVALAWGIARGHSVIPKSKTPSRIKANFEGDFKLDADDVKKVDALDKKIRFNDPSESFRWNFYADLEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU07</accession>
    <name>A0A1C1CU07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU07"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09040"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06147"/>
    <dbReference type="eggNOG" id="ENOG502RKZB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5596743at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058645">
        <property type="entry name" value="NTF2-like_dom_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26534">
        <property type="entry name" value="NTF2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651038" description="NTF2-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="NTF2-like" evidence="2">
        <location>
            <begin position="31"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="182" mass="19307" checksum="A002C9C674CBD9CC" modified="2016-11-02" version="1">MKLSLFLAPLALAAGVVALATPKRTDCQQGCLSQAQAESIISRYISILEHTDVAAANATAQALLDPAYTETSDSILSLEGQPLGTVTFQGKDGYIEGVLNSPPVEGITTIEILVAGCTKILWYWNFLGIGTGEYEVKGFNLFTITPSLQISAVDLEFNSIAWGLNTGYQVIPPADGGAPTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU50</accession>
    <name>A0A1C1CU50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU50"/>
    <dbReference type="STRING" id="86049.A0A1C1CU50"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08545"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06104"/>
    <dbReference type="OrthoDB" id="2426396at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651112" evidence="2">
        <location>
            <begin position="28"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="424" mass="48241" checksum="4A6D73815BED82DE" modified="2016-11-02" version="1">MAPWLRLAALPSALLLLVSASISPAAAQTVNLRWPYNLAPDSKYYPEDEVLLKRDIDIQQKLQRSSPTGVKKLNGDPGEKFYMDYWGFEEEQEEAWDGQSIWSNSTSWVSIDLPVRAGTCFQNEPSSVPQEPRPAHPLTDPTAAVQRDTPANSFRSRAPVRATWDAVPTVKSAAMHFPRTAQVDKYSDCIDHAAGSEYYDCDELHDGHAISAFLAYNKLKAVNHSDINLQSQRHSAATTCLDCHDNQNGDVFSLTFPNVLNRFPILSGQSRRRLLSDRPCMWVRQLPCLVNIDDLLAIEWYTGTTRPTDQFDDDGGNHNHNDHAFEFPVLSGHGLSNRVLRLLRILPGRMLSNRARLRQYILPCGCLHNSCFWIESHDCGTLWERDYRPRRFPDGRLCNRVDDVRARCGWGMLSQWLCLWECEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUS3</accession>
    <name>A0A1C1CUS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dimethylaniline monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUS3"/>
    <dbReference type="STRING" id="86049.A0A1C1CUS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08108"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05925"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT52237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="616" mass="70444" checksum="6D17A13A988EF47F" modified="2016-11-02" version="1">MRVAIIGAGPGGLVTLKYLLEASQRFHVAPIEAKIFEAQDGIGGTFRYRTYPEGEMVSSKFLTTFSDFRIPKGRFPSGDNDFLQLEEYVDYLEDYADHFKLRPHINLNTKVTNVRRAKGGKGHVVTYTSPGGRTEEWACDAVAVCTGLHVETVVPDIPGIEKVPTVLHSSQYKSREIFKEGSNVVILGVGETAMDMAYFAVTSPVKTVTLSHRGGFVLAPKHVERFVVNGEQEPEHNASPVDTNWNSLFDTAYAHPKLRNHRWQWLFYDWWTKGVWVLLNNTRYGYGQHAGIIKGYHMSEVLFVKSTRIQPYFNRRYHTYGNFGQWKNSKIDLPRIDQTERSVEFAPWPEYIDDEGVIHFQKNDSLESKYIETVKIKPDVMIFATGYSHLSFPFLSPGYPDSRDANVRSLWKEGDETVGFIGFIRPQLGAIPPLAEFQAQLWILRILNLLPESNLRHLSPSYDPDAEEWYKLKPRAGARVRHGVDHESYAYQLALDMGAAPSIVDVLKCGRKVFIAWAFGANFNTKFRLVGPWKWDGAAEIMRTEMYELITRRPVFWGHIMLNALPMAIFGPLSLLYWIYFTFYAPFLKRLGLGLSRRPPKRQYIKGHARTPSKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXD2</accession>
    <name>A0A1C1CXD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXD2"/>
    <dbReference type="STRING" id="86049.A0A1C1CXD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09692"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00160"/>
    <dbReference type="eggNOG" id="ENOG502SAP5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3344043at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="638"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="740" mass="80397" checksum="829924D1595F6BFE" modified="2016-11-02" version="1">MTSTNPFWSIAAPLGVQQPHALSSRLSDSLSQSDHTLLPSSEDIASYTQATPDSTWSQASRFTYDTSKGEKVTSSDDESSGQARNWPLTEKYYSTSLADHDLRCLKWTLWKTILLPTSIVILPMACLVAGLLALIFGYRVRSEESLFEEVSNSRTLSNHAVVLVNYSATRIAFVASWASTLAPLLAGFIMSLTSFKYALVMYQSSSGGQQQDLPTPYQYSILVGLCLASMGRLGRYLSYSRGDGVVVPPVLRRAARTLALTLLLACVVFGADTALHYTTSTINFDQVSISQENHAYGYGLSSECLALNRTENFGLPCTRNGVIGATDYDAYVAGQNEIFYLQRGTSNLSEIRLISPPSSMPSNTTSAGVAKVALLAPQSANLSPFRDFQAHTAGVVTTCEPISSQCTWTSEGPGEYWSSFNCSKNFWGVLGKAPNLTDKGMLDGDSAVPPLGFKPGAALQYSFFMDKELATPYDSAGNLGPFMPDTQLINPVYLGVAARFQDTAQRAGVDMSSDPGIYRGPTRYLDFTLRCRYTTYLVDYAWVNSTTKVRTLTPSPNGTMAEMFHGYNILGASDSFDNNLQDFILEAALQPTAQALADSFANSYSSRIMSVIGPFLSKRANVQEQMRTPLLVAKVPKIPLAILVAGCCCYIIFGCVCAVGAYRALRTMDVRDLAFRFSLPALGLHAFRDVSVERGAVDVDVGGSAEDSHRVFDETKIRGETMRVAVEGNPKSGFVLTSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXW0</accession>
    <name>A0A1C1CXW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CLCR_09470</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXW0"/>
    <dbReference type="STRING" id="86049.A0A1C1CXW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09470"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00211"/>
    <dbReference type="eggNOG" id="KOG0216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12 19" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="16">
        <location>
            <begin position="49"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="218"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="498"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="18">
        <location>
            <begin position="602"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="13">
        <location>
            <begin position="709"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="14">
        <location>
            <begin position="1090"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCT53250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1220" mass="136484" checksum="0168808EB3EDB94B" modified="2016-11-02" version="1">MSATTTATTTQTRTKSKTSWSVEFDTVRRHKLFRHTPKDRSAYPALQAAVKPHVDAFNALWDEGLIDAGLKDIGTYTVVDGDVRNPSKSIHHNKLDLRVTEVILEKPTLPPSNKFAIENRNIYPAECRERHASYRGRLKARLQYRVNKGEWQESVRDLGQMPIMLRSNKCHLEKFSPAQMVRHKEEAEELGGYFIVNGNEKLIRMLIAPRRNYPMAISRNAFQARGPTFSKLAMQIRSVRPDQTSQTNVLHYLTDGNVTFRFSWRKNEYLVPVVMILKALVDTNDREIAEGIIGSNSSRKAPSSFVADRTELLLRTYKAYNLKTRQQTLAYLGEKFRPVLMQPITIADEKVGEEFLRKVVLPHLGNVDVRPSQNNDKFQLLLFMIRKLYALAAGDCALDNPDAVSSQEILLGGFLYGMILKENIYEWLVGIGAAAREWSRIKNGAQFSDPSFEADFLPKIVRRTNENLAGKLEYFLSTGNLVSQTGLDLSQTSGFTIVAEKINFYRFISHFRCIHRGTFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCGLLNHLAHQCQVQIKRIDTSGIEKAVVQMGLSPTAPMALTDGLSVQLDGRILGYCPAKRAREIAQLLRHWKVNGAHNIPNELEIGYIPTSNGGLYPGLYLFSDPSRMLRPVKYIPSDKLDYVGPFEQQYMNIACVEADIIPNLTTHIEFKPTNILSILANMTPFSDFNQSPRNMYQCQMSKQAMGTPSSNLMCRTDNKAYLLQTGQTPVVRPPLYNEYGLDNFPNGMNAVVAVISYTGYDMDDAMIINKSSHERGFGDGVIYKTKVYKLNEDQRATRSKTEIKSLFGFADGDPNISPEAVKSLDPDGLPAIGTKVGEGSIVLAYHTVMFDPSEGKLKNLDGNTMYFKYKDAEEAYVDQIRLIGAESGDQPCQAISIKYRIPRRPIIGDKFSSRHGQKGVLSMLWPSADMPFSESGIQPDVIINPHAFPSRMTIGMFVESLAGKSGALHGLAQDCTPFSFDEDNTAGNFFGDQLRQAGYNFYGNEPMYSGITGKEFAADIYIGVVYYQRLRHMVSDKFQVRTTGPVNALHGQPIKGRSKGGGIRVGEMERDSLIAHGCAYLLQDRLMDCSDKTRAWVCRSCGSFLSTTMVPNQFTAGKKGGRVEPSGMVRCRACARQATFEDSKMTVWEDGAGRKFVGGDNTTVVNVPGVLRYLDVELAAMGVRTKFEIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXZ2</accession>
    <name>A0A1C1CXZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10706"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00329"/>
    <dbReference type="OrthoDB" id="4158559at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="262" mass="26707" checksum="AAFB2EA46D552277" modified="2016-11-02" version="1">MAPASLALLPRQFGNGNGDGNGRFGDRDDGGISRWAIIGVVVAVLVAAGIVGLVLFRRMRRRRSAVSFSAAAINLASTSTAAHKPTSTGPSGSGNGNGPPKYGASTTGYGVTPDQSQSLLGNAEPPAIVMWGPPPSDNAGSTQDGFGYDNNLQLAGTGIQRPASVASFSAPPPRYEEATNASAGGAASAAAASRPQGQGEAASYFNAAVPLGDNTDRSQSRGRALSLDTRSLNGDGRRSISRSRFREEGMVDVNVSVNADKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY41</accession>
    <name>A0A1C1CY41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cdc37</name>
        <name evidence="10" type="ORF">CLCR_10051</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY41"/>
    <dbReference type="STRING" id="86049.A0A1C1CY41"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10051"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00407"/>
    <dbReference type="eggNOG" id="KOG2260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000002">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="199"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="7">
        <location>
            <begin position="413"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="487"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT53439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="533" mass="59598" checksum="37E55430FB62A57C" modified="2016-11-02" version="1">MPIDYNKWDRLEVSDDSDVEVHPNVDTKSFIRAKQRQIHEQRAQRKHEIETLKYERIVNDGLLERINALLDALKKHQTEAAQKNPDELVFQSLIESAGDPAKDEPPKPPEGVYTHQKEQPRYSKMMGALIDQVKKEVDEKKDSSTDRYADFVQGVHGHLTKVQNLQQDLLKRLAQLEKEATAKITSEDIHVGFDSSHVNKPKPKPAKTEKPKAKESTKTETVELLNAPKGISSKTRDALQPVDGGVSSGAEADIEDGSLLEKHEDDDEEDEVNIKLTPEGKEFAKIKIGDYRACLQYISEHPEIVNEKTQDALMIEAFNAQMKGQDAHARTCVHQSLLIQYCRQLGRDGVGMFFKRITTKGHQAQQVFNKDLAETYGRIKVRAAELQKEEGNDPAGVEQIQLHAVEPGTEIHINVPQADSDDPVEQEARKIFDRFPPGLQRALQSGSLDEVNKVLGKMSVEEAEEIVELLGQGGMLSLQEGVIDATNEEGQKRLKEIEEEEKRKKADMGKSSEAGEAQGLGEPGDAVDAYDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYJ3</accession>
    <name>A0A1C1CYJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10873"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="188" mass="20941" checksum="D21564D51D5A6F29" modified="2016-11-02" version="1">MVYQSLKLQQERGYWLMGRIGKGDLGDKVEGEWSSPWETGPGESGSPAGIELKRVAVRTLSRRTANDLAWWAVSVFDASRVSWSNSSAVGSHRGRLGERVGIAEGRDLFLKGDRGPSSPALPWWFPMSLEHSVRTCPYVMSPVGVGTLYPPARTTITSGRRLNEQLLDVVAICQRRRMAIVIKRETER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ05</accession>
    <name>A0A1C1CZ05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative MFS-type transporter PB1E7.08c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_09858</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ05"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09858"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00701"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="46"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT53774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="524" mass="56738" checksum="8285E4B5E432421D" modified="2016-11-02" version="1">MGVPEDTKVATASPASDEAAEVGSVRELKTLHVDGVDPVFEHQARLVNHAVQSIGMGKYQWALFFLCGYGWLCDQTTVSDALGQVAVEFQPQHSAFLSLALIAGLVVGASFWGLGCDLIGRRLAFNLTLLIAGVFGTAAGAANSFVSCAVLVSFCGFGVGGNLPVDSAVFLEFLPGTHQYLLEILAVWWSIGQAIPAGAAWGFISRYSCSEDTPAGQCQKKDNMGWRYLMYSMGAITLAAFFLRFAFFRLRESPRYLIGQRRYQEAIDVLNDVAKYNGTTQPLTVEDLLQVERDYAVAGHPAAVDRPTAWQRTMAQFKPGGFKHIRALFSTKKVAYSTSLIILVWGMIGLASPLYANFLPQYLALHGAQAGSGSLDITYRNNFIIIACSIPGTLMAGWFIGLPKIGRRGTLGIALILTAVFQFAFTTARTQASILAFNCITSFVSYIMWGALYCYTPEVIPSIHRGTGCGLASAFNRICGLQAPIIATYVGYNNKPIFVSASLYIVAGFISFIFPYETSGKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZA5</accession>
    <name>A0A1C1CZA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZA5"/>
    <dbReference type="STRING" id="86049.A0A1C1CZA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10079"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00742"/>
    <dbReference type="eggNOG" id="ENOG502R0TM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="380"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="493" mass="55469" checksum="4BA6E978A6AAFDF8" modified="2016-11-02" version="1">MSSIPRPAYPPSLADWQDHRSVITRLYVEEDRNLSEVQHILCHRYHFRSSLRSYKNRLRGWGIRKHYKTTSSRIRSSAAVLFDPELTSLSSFSSESRVSHIKSEDSDAAMSCCRVLAPASIDSGGTPQHSDALPVGILTPVDDGGAMMKRQPSHTTSIPNFMLKDELSDTTNSIIMAAKAFITTAAAADLGHLPTQISSEQSVKQTRPFRRRKNYIWHQFQHGLTLLEQANVPGAFDDLQRGCAMAEAYLRRPTRQVLMSLLAVMGNRRWRRHQRAWTSVVRFMASMSSKTLGPRHPLACIMNNMGSWDMMRIAARPAMRVILDTSSRTLGPGHPEVLLLQQGLCVELMRDGAFDASEAVILEACETSAATHGPTSLARRNCLRRLGNLYVEQQRWDDAETVFETVIALDSEANNGYHGPTDETSVFTCQNLSLLNCQRGDLARSDYWAQQELDLALKVYGPEDDYYADCLNRKSARLNGEPCDRWFSWLEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZK1</accession>
    <name>A0A1C1CZK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZK1"/>
    <dbReference type="STRING" id="86049.A0A1C1CZK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10589"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00881"/>
    <dbReference type="eggNOG" id="KOG4288">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="292" mass="31085" checksum="7D48E6E555419F87" modified="2016-11-02" version="1">MAQAVKRKLVVAGGNGFLGSRICKSAVARGWDVTSISRSGEPTWSSVTSESAKPPWSDDVTWAKGDILKPSTYTSYLKDADAVVHTMGILLEADYKGVLSGKESVLSGLSRAFSSNKAGSSTNPLDRKPGEGLEKGEKDGQITYELMNRDSAIALAQEAEREGATTFVYISAAAGAPILPTRYITTKREAESTIASQMIKLRNIFVRPGFLYDNSRKFTLPIAASGMLGSTVNSLVGGGLTTLFGAAVEKPLKADLVADAVVEAIADDETKGVIDTKMIEALAARAWRRTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZV4</accession>
    <name>A0A1C1CZV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10383"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00912"/>
    <dbReference type="eggNOG" id="ENOG502RVYM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4149815at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="380" mass="44701" checksum="40C1985B89791A5B" modified="2016-11-02" version="1">MSARDSDRPYKVVYSSRRREEIDDSTPSRRPRRELEYEDDYRRERVYSRGSRDDRVEGDRDRQSRTSDSRNVLPAAGTTKTRYAVGRDRNAEAYVKRSDAVIVEDRPSDHGRYEYEVLRPQKRDDGTYVVDIGGGGGGGYSQDYTLDFDSRQPRLRRDAPPPSRRDDLLYDGHRGGGRDRTVRDVAYRDVHVTEEIDDTRYSGRGRTYEAYAEDIPPPRRLKSAMRGGNSSPPDLHRWASVGFYRDQISNHDASESRHERPGAEAHLAGRYLQGNGLVDDDVYATGYTRRNRSRSRSRGRYGPQRSDPRLHEYDEVDEERRTFTEQTMRQYEYEDDQRPAYPPQRATSRRRHHRHHRDDDDRSSQFETELVKRTTKEYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZW2</accession>
    <name>A0A1C1CZW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">KAE1</name>
        <name evidence="11" type="ORF">CLCR_10362</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZW2"/>
    <dbReference type="STRING" id="86049.A0A1C1CZW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10362"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00944"/>
    <dbReference type="eggNOG" id="KOG2708">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="10">
        <location>
            <begin position="50"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="155"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT54047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="386" mass="41294" checksum="93B20ADCA1D5E663" modified="2016-11-02" version="1">MPIALGLEGSANKLGVGLIYHSGVPDTATYSSSYPSKQAQSRSQPEVRILSNIRHTYHAPPGAGFLPKDTALHHRSHVTTLVGQALQEADISPADVDCICYTRGPGMGAPLQSVALAARTLSLMWDKPLVGVNHCIGHIEMGRSITGATNPVVLYVSGGNTQVIAYSMQRYRIFGETLDIAVGNTLDRFARTLAIPNDPAPGYNIEQMAKAAAAAAAALAPAPAPAPPILVDLPYAVKGMDCSFSGILARVDELAVSCLRGKLVDPASGRKVTPEDLCFSLQETVFAMLVEITERAMAHVGSNQVLIVGGVGCNERLQEMMGQMARSRGGDVYATDERFCIDNGIMIAHAGLLEFLGGDKKGIRLEDSTCTQRFRTDDVFVRWRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0G0</accession>
    <name>A0A1C1D0G0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0G0"/>
    <dbReference type="STRING" id="86049.A0A1C1D0G0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00793"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01592"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT54313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="618" mass="67116" checksum="EF2575D5FE348B82" modified="2016-11-02" version="1">MPVTNGVNGHVNGTSSALCSVEDLTSRQYDFIVVGGGTAGLVVAARLTEDPNISVAVLEAGENRMDDPSVSTPSLYPTLIGRPQYDWCMTSIPQPNAGNKIYSMPRGKILGGSSGINYLMYVRPSRNDLNGWEAMGNPGWGWDGLARYFVKSQTLDKTELHDDPQFMPIAGGDKFHGTSGPIHTSFNDWYMPLEVDFAKAAHEVTGTPKTISDAWSGDHLGFFSSLGAVNRTDDPGKRSYAATGYLRPNLGRKNLKVLTEAQATKIVLDGNKATGVEFVHKGKKHTVQATREVVLSAGVIQSPQLLELSGVGDPEVLQAAGVECVVENKGVGANFQDHVLGGLLFDLKPGIDSMDALHEEDFNKMQQDVYQKTQKGPYASPGMMMGFVSYASVASPEELEATIKEIEQKSLAKTDFEKAQEKVIVDQLRDPTFANLQTFCIPCRLDVGKGSDQTQFFGAPHNGKRQLSLLMCLEHPLSRGTVHIKSSDPLAAPEIDPGYFRNEVDAKILAAGMKWMEKVSKHPLLAKSLARRELPPEDQGLETEEARIDYVKNHISTQYHLIGTCALGEVVDNDLKVKGVKGLRVVDASIFPGHVSGNIMATTYAVAEKGADLIKKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0K8</accession>
    <name>A0A1C1D0K8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription elongation factor S-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0K8"/>
    <dbReference type="STRING" id="86049.A0A1C1D0K8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00339"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09466"/>
    <dbReference type="eggNOG" id="ENOG502SDPH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3352776at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="148" mass="16434" checksum="DAA2FB3BC0F9CFB9" modified="2016-11-02" version="1">MPASKRDALLAAAQAFCNSFANKEAPANVLSHFSSSDDVLAVEHGLPQLAPFLGREFRGQAGLEAYFQLLSSYLKYEDMKFSNFVVDAEVSKVSVRGEATFTWISTGQSWDEVFTYVLEFDQENRVLVYEVWADSGAAYLASKAQLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0X9</accession>
    <name>A0A1C1D0X9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0X9"/>
    <dbReference type="STRING" id="86049.A0A1C1D0X9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00909"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01760"/>
    <dbReference type="eggNOG" id="ENOG502RZRD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="150"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32079" checksum="B638067F8212FA82" modified="2016-11-02" version="1">MHPGAPHFKLYSSPASQWAGVPLLGLVEKGYDEKEYEVENIDLMGAGNFHPDYVKINRNGTIPSLTSASLEQPLIESADILVYLNDSLPSGLNLAAKDDATSRAVTQLVDLVHSPEVSTNIILLMARDAEEMQAKQNGPFNDFLRKRQDTLEKYHQEIPDSDFYSARRDMNGAIYHHYVSSDGHPQFFQQSQEAYRGFAAGMDKLESLIVLPYAAGSELTFADLHIVPWLAHAMFGAGAKELDDFGSLENLIGKTVPDFKVGPKTREWWGNMMKRESFKRVYPFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1Q2</accession>
    <name>A0A1C1D1Q2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cryptochrome DASH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_02826</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May have a photoreceptor function.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
        <text evidence="7">Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5 7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1Q2"/>
    <dbReference type="STRING" id="86049.A0A1C1D1Q2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02826"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04915"/>
    <dbReference type="eggNOG" id="KOG0133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000719">
        <property type="term" value="P:photoreactive repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014133">
        <property type="entry name" value="Cry_DASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02765">
        <property type="entry name" value="crypto_DASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF22">
        <property type="entry name" value="CRYPTOCHROME DASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="9">
        <location>
            <begin position="5"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="555"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="556"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="304"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="463"/>
            <end position="465"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT54823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="629" mass="70082" checksum="B1A8DB19C63D5A53" modified="2016-11-02" version="1">MTAQRVLIYLLRRDLRLADNPVLHEIHKLSQQPQCPFSHVLPLYVFPAQQIEVSGFLADRNSGSPYPEARSEIGRFWRCGPHRVKFLAESIWDMKMELEKAGSGLLIRVGLLGQVIEDLLRQFQQAEEEVSVAAVWMTEEEGVEEKREENDVRKAAEKFGVNFRLWLDEKYFIDDRDLPFDKPTDLPDVFTSYRKSVEPLRDAPRKPVPRPSSLPPMPSPIPAKTEPFSIPETYEGLESALMRPLKDSPPLPKPPSFPSSGVKTAHPYRGGTSGGLKRVQSLIGSGAMTRYKDTRNGLLGTDFSTKLSAWLALGCITARQIHAQLLDFEDGRDDQYHGTEGYGKGENKGTAAVRFELLWRDYMRLCTRKFGPRLFRLEGFRNDTSYPWKTPGSKSSGPEVATMLDRFLRGTTGTSLIDASQRELFLTGYTSNRARQNVASYLAKHLGMNWKLGAEWYECMLTDYDVSSNWGNWQYVAGVGNDPRGEARVFNPIKQCCDYDPQGEYCKAWVEELRGLDDPQEIFQPWKVSKANRAELGLAGLETVEDPLKKIDFKVGGKGRSGPGGGRYGGSSRGKANGGGEGGRGRGGGSFGARGAYRGQGKGERRRGYGRQGIMGRAAGQAVAAEHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D201</accession>
    <name>A0A1C1D201_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative pyruvate dehydrogenase protein X component, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_02936</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D201"/>
    <dbReference type="STRING" id="86049.A0A1C1D201"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02936"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04820"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202158at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="41"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="188"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="471" mass="49651" checksum="71CF81B73BCE3187" modified="2016-11-02" version="1">MAGRQSVRLLARQLTSSQCTLSQSQHHARRAFSSTPSALAAHNFTMPAMSPTMTEGNISSWKVKEGDSFSAGDILLEIETDKASMDVEAQEDGVVAKIFQGDGSKSVQVGTRIAVLADAGDDVSSLEIPADDSKPVQSQSENIKGGDDAKYESSGAEKNTPGTPQDPRPAKDKPKTSPKGPGANPKYPLYPSVIALIHENHIPDADVAKIAATGPNGRLLKGDVLAYLGTIASDYSAEQSKRIEYMGHLDLSNIKVLPATPENKPAPSEDTTRGKAAAAAAEVAPVTSVSLTISLSEVLKVQKRVKDTLGVTVPISTFLARAVDLANDDLPNPKNAKPSADDLFNAVLGLTAIPTTSRGTYLPQIDAFPILPPPNARQATTPSSRSPRLGTSAAKKIDILDILSGKVTPPRRGAAPLSTAASIPGRTMTTTSEGALNVFSLTVPKGEEKRARTFLERMKTVLQVEPGKLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2H8</accession>
    <name>A0A1C1D2H8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2H8"/>
    <dbReference type="STRING" id="86049.A0A1C1D2H8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03004"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05082"/>
    <dbReference type="eggNOG" id="ENOG502RYM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="370" mass="42637" checksum="52DC08FE2486CD69" modified="2016-11-02" version="1">MWRLRPSVAVIAAVSVLLLWWHLPRYQDADVKRLPLTTTQYTPEGATIEYLPGTPKAQGQSYTKTVVVARQESEDVSWLEKSGLNVSQAIYVVDKPSLSPGHEIPRNKGHEAMVYLSYIIDHYDDLSDVSIFVHAHRTTWHNNDLLDSDMVKTIEHLSDAHVIRAGYFNLRCHHEPGCPDWLHLDRPDEELDTHRKMEERAFSLTVWTELHPNVLPPPKAISQPCCAQFAVSRDRIRAIPREEYVRYRDWILHTELSDVFSGRVMEYTWQFLFAGVSELCPAMHVCYCDGYGICFGGAEQFQQWFDMRAEMRQLQAEEGEVPAEAEEARARVQDMEARLEQLKQEAFARGSDPRLRALEAGRPWREGDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2I2</accession>
    <name>A0A1C1D2I2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2I2"/>
    <dbReference type="STRING" id="86049.A0A1C1D2I2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02888"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05182"/>
    <dbReference type="OrthoDB" id="5537330at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.20">
        <property type="entry name" value="Insect antifreeze protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT55093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="485" mass="52222" checksum="596C2D5642805B65" modified="2016-11-02" version="1">MAPTKGFTIFARAWKATSPPPCTYKMHDPLTRIPSPPISDDEQSIDASRCANGVDVEVSSDTSTARTTAETADSPARFETSSAASSSSTTVSSPPLELPSAVSSTTTVSSTPSDLPSAASSTTTGSSPPSEPSKPRSRQRVDFAKLQSIFATESATDSTDPTPSPSLSSLWYILTTALLLAFHKEKLIADLWTYLAVNVARASGTNDDDDDHNLLTTARHIREASLKASTLVGFPRAINALLTLHRAIQSSHPALSTVLQGDSSLRSSPWLSPADKFNRGMALFQTIYDKHTARVVSTMSSCSGGDLTHFAIQCIYGELLAENAIIGDLGTGMLEFVCCLADGVAPQAKGHFFGSVNLGATRGQLRGAVLMAQELARQVRVPCAWDGGPEEERDEGEEEEEEDMDEWKFLQRVTIEETTVEETTVEETTVEETTVEETTVEETTVEETTVEETTVEETTVEETTVEETTVEETTVEETTVEETTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C664</accession>
    <name>A0A1C1C664_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neutral ceramidase</fullName>
            <ecNumber evidence="5">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_00083</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the neutral ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C664"/>
    <dbReference type="STRING" id="86049.A0A1C1C664"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00083"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02033"/>
    <dbReference type="eggNOG" id="KOG2232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650630" description="Neutral ceramidase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="7">
        <location>
            <begin position="61"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="8">
        <location>
            <begin position="617"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="785" mass="85754" checksum="73EAAB517CE56BCC" modified="2016-11-02" version="1">MARIWATPALYMLFVALVTAALWVCFALQSPPQTSPLVRANTYGANERDHLGDDAVVQGDYLLGVGKADITGYDSLVTSSTRYADLVFVRPVVEINLMGYADTDQAGTGLRQRIYCRAFIVGSLSKNSSRIVYLVLDTQSGDTAVRHGILQRLKEMGPEYQVYTKNNVAVTGTHSHSGPGAWLNYLLPQITSLGFDKQSYGAIVNGSVLAIQRAHESLAPGFLSFGQQVVVDGNINRSPFAYLQNPKDERAKYAADVDKNLTLLRFERATDGQSLGLLSWFPVHGTSLYQNNTLITGDNKGVAAYLAEESMKEHNPDFVAGFSQANVGDTSPNTLGAFCEDTGLACSFNDSTCGGRSERCHGRGPFFQQDDQGTRSCFDIGKRQMTAAQQLLGSDSLERIPPSTISFFHTYANLSSFSFISPFNRSRTLRTCSAALGYSFPGGTTDGPGRFDFAQGTNDTDGDSPSLKNPLWRIARGAVHPPSDEQIACQSPKPILLDVGEAHEPYAWTPNIVDIQLLRIGPLIIIVSPGEATTMSGRRWKSALASAAPSILKIDNPTVVLGGPANTYAHYIATEEEYSVQRYEGASTLYGPHTLAAYINLTLTHLPYLGSEDETSRLDRLPPGPCPPINVNRSLSFITPVVVDHAGLLRRFGDTLASPDPAKAHYPGEIVSARFVGANPRNSLRLEGTFASVEFFNDTVAEWVAVRSDRDWFLVYKWKRTSTALGTSEVTLEWEIERGTAPGMYRFRYFGDWKALTGKITAFEGTSGVFHIGEDSQGELVRYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C736</accession>
    <name>A0A1C1C736_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C736"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05877"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07040"/>
    <dbReference type="OrthoDB" id="10643037at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="455" mass="46728" checksum="368408FC900AEEDE" modified="2016-11-02" version="1">MTGREVSTLTDPRTVRYDPLEVIPAKILYIPPLTTNTECDPVTGQSFSSTRPQAGSALTVDHSRAGQSQDWQPGNHTVSCTSTDVSFSTHTSPWVSLSATQTNAGHKPEPASATIVTCCNTSIPPTQGFPLPSWRPPPLFSFDISSSLSLSPTSTTTVRVRTTTYVTRNVTVSGPPLMQTHSGGEYTSIDSLGSSMTKDTNTDTNTSYGPIGSFTVSPIPHAGPGGVSTISPPSSASASASASATLSTTSTLDIASPATRTTTLVKTVIVTASPAVLAASSSSAPVGSVTSTESSFTTRFQAESSQISRTTTSGDVSPDTAGTRTMAPTTMPDPMLSSSSSPSPSPRPSEAHVANTSIILSECSIVFGTSTPETCTLGPPAVTVHASQGGGGGGGGRRRHPERRAEAEAYSNAGQRPVTHTVVVLTLWGGGGADDGRMAPQASTLRTVPVAETVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C744</accession>
    <name>A0A1C1C744_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_05912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C744"/>
    <dbReference type="STRING" id="86049.A0A1C1C744"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05912"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07048"/>
    <dbReference type="eggNOG" id="ENOG502S2R6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5364404at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="7">
        <location>
            <begin position="388"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="422" mass="47138" checksum="8F4581602F948C8F" modified="2016-11-02" version="1">MASRTPQSTLRSLLSTGGPMFNTSLRRVARNCGNGSPIPSRPSTPTIATFSSNSHQRRHSSSKPPTPPNNGSPPIPAAQVKQVGAPRSESKRPGAESRLSKKRASKDKLDAKQETQENWTSKLPAVPSLQHLNPKGTSADVYVASFFSTYRPMSITGAVPTETSLEAIDKLFAPKPKRSRNNTQDVIYTLASAVERLDEHIAEKQHAHPSQSQSAEQKAALIKALTQRNETPIDPNRTHHLDGAPSQTINLNGGNVKLVIQEIQRRFRPFNVPPVPQPISDADIDAAEAKAAEVEKQEEMQAKTLEVEIEQQEYDHDPYIQQVVIDVPRDADLQNGRFFTSGTTMMEIQTTEAGEAVPEMEPRRSSIGRRRRTGYISPSRRRPQGTMYAISVKRQRRLKMKKHKYKKLMRKTRNLRRKLGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7A7</accession>
    <name>A0A1C1C7A7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7A7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06476"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT44413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="90" mass="10150" checksum="913F16415963F8B3" modified="2016-11-02" version="1">MGPHGGSSIAAQPNLVANFIDGTSKSFEEVTSYAVMWRLTILRTKSNRQEQQQVQQQLACQVAWKAPMVYTIGFERDVFCKPARLEAIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7B2</accession>
    <name>A0A1C1C7B2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">Glutathione reductase</fullName>
            <ecNumber evidence="3 17">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CLCR_05638</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 17">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="14">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 17"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7B2"/>
    <dbReference type="STRING" id="86049.A0A1C1C7B2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05638"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07063"/>
    <dbReference type="eggNOG" id="KOG0405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000141">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF1">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 14 16" id="KW-0274">FAD</keyword>
    <keyword evidence="6 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="8 17" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11 16" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="19">
        <location>
            <begin position="73"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="18">
        <location>
            <begin position="428"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="214"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="250"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="15">
        <location>
            <begin position="111"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCT44367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="543" mass="59188" checksum="B5F1F1F3865B2EA8" modified="2016-11-02" version="1">MSIVSRRLWRLSAAACTPSPTLALASTRPSSAFESLPASPRSSSASASASRLSSLTRQFSSTAAKMAPITKQYDYIVIGGGSGGSGAARRASGWYGAKTCIIDAGVSGGCCVNVGCVPKKMTWNFASISEAVAAGKHYGYTFGDNNSFDFKTFVEKRDARIKVLNGAYENNWAKEGIELIHGTATFISEHEMEVKPKDGSEAFRVTAPHITIATGSYPTKPEGIKGSEYGITSDEYFAIKYLPKKMIFVGAGYIAVELAGVMNAIGVETHLFIRGDTFLRKFDPMIQETMTKHYEEIGVHVHRNHPGIKEVIQLNPGDEAGSDPREKKLKVIMNDGSEMETNELLWAIGRSPEDRGLGLENIDIKRNEKGHIVVDKYQNSSVSGVYALGDVTGQAELTPVAIAAGRQLGNRLFGPPQFKDAHLDYDRIPSVVFSHPECGTTGLTEPQAIERYGKENVKVYHTKFSAMFYDVYPPEEKKKEPTEFKIVCQGPREEIVGLHILGRGVDEMMQGFGVAVKMGATKKDFDSCVAIHPTSAEELVTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C810</accession>
    <name>A0A1C1C810_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_06201</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C810"/>
    <dbReference type="STRING" id="86049.A0A1C1C810"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06201"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07345"/>
    <dbReference type="eggNOG" id="ENOG502QQJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="52"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT44674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="275" mass="31719" checksum="0336F0CE0A0A6621" modified="2016-11-02" version="1">MASTIMNYLGFGARPVGVESASPVRALPSSWYTSQEMYELERRAIFSRKWMLITHQVRLAQPGDWLKFDIAGFEFILSRDRKGDVHAFHNVCRHRAFPVVEGQQGTSKIFACKYHGWSYGLDGKLAKAPKYDELEDFDKSRNGLFPIHVHVDTNGFIWVNLDGRQKPEVTWEDDFAGIDMQERFKQYDFDDYVFDHTYHMEGAYNWKILADNFNECYHCPTTHPDVPTLADIQTHEVDTARGWITHKSSLTEEQAKNGLGISSTYYFPNVSLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C858</accession>
    <name>A0A1C1C858_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_05869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C858"/>
    <dbReference type="STRING" id="86049.A0A1C1C858"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05869"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07313"/>
    <dbReference type="eggNOG" id="KOG2980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="352"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="173"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT44642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="434" mass="49074" checksum="621F37013606E570" modified="2016-11-02" version="1">MSTVPFLPPCRFSQTAVARKLKPYGSDKKPEQGLRFQDQDLSDDQILAIFGRDAPPAQFANRVLRVLHGRRTDGTLDLPLPKDVESQLEEYPDAVENGLQYLRQAYPIDEDEAIMYRIEREEDPREKDHPSVLMQRGQDLGLYKTQAASPEAYYGPQSGYYQAELSEKEHDPYGKSELDRIRAENDAKRAKEEEELQAQIDAEMAKAQELHEERTRAIAQRPEQGLETAKELRPPNSFERWVLRARNRAQSKLALDSPEIAHMSTFQRVFPSFLLAVSLCVGCYFFAQAWTRPKQSDRFFPDVSLSSATVGALIALNAAVWVLWKLPPYWSMLNKYFLFVPAYPYALSNLGTLFSHQKLWHLSMNMLALAIFGLPLHEEIGRGNFLAIYFASGLIGGFASFARHVIQGNMATSVLGASGCVYGIMSAYLALHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8J7</accession>
    <name>A0A1C1C8J7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Telomere repeat-binding factor dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_05689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8J7"/>
    <dbReference type="STRING" id="86049.A0A1C1C8J7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05689"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07481"/>
    <dbReference type="eggNOG" id="ENOG502QRT9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3366990at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013867">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052833">
        <property type="entry name" value="Telomeric_DNA-bd_trans-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807:SF1">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08558">
        <property type="entry name" value="TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere repeat-binding factor dimerisation" evidence="4">
        <location>
            <begin position="153"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="443"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="574" mass="61330" checksum="E1E1F707ED367E64" modified="2016-11-02" version="1">MDQVSTGDRPAEAISQGSAPHQDRVSTPTPSSPGHVDDNPRSPKRRRISTDGTAPDVKPETKVEDSGNPAVHANRPASPHGQAQHEETEATQEEQAGNATPISTDVQAQSITQSASGGQPQSAPRPPAGQAHNVASQPPQRPTPPGNGPLEYLPILDQQASQILAFLSRLTPAEAMGLSTRPNAASSRAYASLRAAFDRTRRLVSPGWPFLPQHDLGLQDTNQIEIIRKANQAIFMSSIFTGEIGLRDMDRSFLPVFVPENGGLLKEQGTMFLELKTQGFITAWRTGAAPPDLVMRDMFGPDLDKVLLARRPGSTALTDTEREFLRMLNSRRGILESAVKTKTLDQLPVTYKWEDFSREVSSYLINHIMKTGSNGTGLANMERNGSTNNLDPGHTQGHIPDHGLPVPVSSMGFNLSEPLVKEDFVALAARAAEIALRSTLGLSSSDQIPDLPSSNTPTAAATPTKSRDISTSQPAAPEPKVAETDKTINPPELPTPEQKALEREASHQGNVTGDIAHVSQIAPVKQEAEMGGGVEEGPVGIDTVESVVKQEAPIIAEDGPAAPSSETKQPLEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8M3</accession>
    <name>A0A1C1C8M3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerophosphodiester phosphodiesterase GDE1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GDE1</name>
        <name evidence="8" type="ORF">CLCR_05370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8M3"/>
    <dbReference type="STRING" id="86049.A0A1C1C8M3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05370"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07485"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="197419at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08606">
        <property type="entry name" value="GDPD_YPL110cp_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14484">
        <property type="entry name" value="SPX_GDE1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="6">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="461"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="532"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="7">
        <location>
            <begin position="814"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="590"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="915"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1156"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="915"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="933"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1233" mass="135301" checksum="39E7791E3779BE3C" modified="2016-11-02" version="1">MKFGRNLPRNQVPEWATAYINYKGLKKLIKAAAKGGSEEKQEGDGPDLAGFFYTLDRNLEDVDHFYNKKYQDFSRRLKLLEDRYGVSPQAVAQLDADEREDLLAALLELRGQLRNLRWYGEVNRRGFIKITKKLDKRIPQAHAQKKYLELKVDPLAFATNAQLFASLSKINDGISVLGEAASSSTSKTDDVASISSGSLMRTTSRPSLHISAEQLAKIEAIIRQDDATSLDEWVKDIKQASENPEAAIQLLLNTLLQRAISSRSRACTASLLREIVFLDAQDDINRRNCIHRLVISIGRKQNNADQDPAAETPPDAETALYSYITPADHPSPALKRSILQEDQRVQLTTRDDESISFLQFLLDNLRPSQRPSLLARDSAGKTPLHFAAEYGVKVMCEVIIEHLTVWKLFDVSEGIDGPRWQDQEGWAPLHLSSVGGHPLTTKALLDAEKAMGVRIKQRPSKSSAVLALATKANYVEIVRLLINAGVNINHQDEQGDTALHVAARFGHVECAKLLLEGTDNQKADVEVAEHTYGWTPLFIACVDGQAPIVELLIEHGADLERLDSSGWNAKEHAALRGHVNIAQKLDSVMPQPEPEADVSMTGTSPPVSSSLSAALTERKSNGLGSNGQNVKTTEPVKTFGHRYLTDKSMVLVSLGTMDTRKAVKAVNLDKIPLSNAHSTQLDTALSVVVSAKAAEGEAEVIDLPVQDNISTEPIVFYATDPSKVKIYFDLVPTYAGSQNRVVGRGVALLSSVKSDVGRKRMSLQGDVTVPIVAASDLEVIGSVTFNFLVVTPFSHPNMSVTENQTYWKSMASNTMLIGHRGLGKNLAAGRRSLQLGENTIQSFIAAANLGASYVEFDVQLTKDHVPVIYHDFLVSETGIDAPVHTLTLEQFLHVNDVRTPRPSRPASPVAFEILNRKENPRNGNRDPRASRLRSMSMNGADNTESLEMDERMKHTRDFKKKGFKGNSRGNHIQAPFATLEEMFKKIPQEVGFNIEMKYPMLFESEDEEMDTYAVELNSFVDTVLTKVYDLGKGRNIIFSSFNPDICLMLSFKQPSIPVLFLTDSGTSPAGDIRATSLQEAIRFASRWNLLGIVSAAEPLVAAPRLVRVVKESGLVCVSYGVLNNDNKMVRRQVRQGIDAVIVDNVLAIRRGLTEDAAKANGNGPGTGTMTSPSSAKAGDKEDSLNGDADVALEKQLLNDMETLKIPDAVHSVKQVGLKAETLVNGNDDGNGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C926</accession>
    <name>A0A1C1C926_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C926"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05894"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07707"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="345" mass="37381" checksum="7677C4623962A27E" modified="2016-11-02" version="1">MAPSTWVVVGASRGIGLELVRQLLGRGNQVIAAVRAPETANEIWQLAAQQTRPAACLIEQCDVTKEASIDAFVGAMKRLIDQGVRIENIVLNAGILKYPNQRATEISFGDFALHLHTNTIGPIIIAQKLLKISEAAPPAKVIFISSDSGSTQLFRDHEDGFGAYGASKAALNQMLRHMAAELKRKGGKHADVCVLAMHPGEVQTDMANIDLDWEVEGIITPEESVRKMLVVLAEKGKDDSGTFWCWDGRLRAQVSLGSVLILYPVGGHGDTRVFYRRRTTRLSCAGRDTVVRSVPKLKATATTTATATALATRYFQKPCTQYGEKGSATAATTIWGVPSRLPLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C986</accession>
    <name>A0A1C1C986_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_05928</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C986"/>
    <dbReference type="STRING" id="86049.A0A1C1C986"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05928"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07681"/>
    <dbReference type="eggNOG" id="KOG1506">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="14"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="126"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="248"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT45008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="391" mass="42834" checksum="5A57B32373A57E46" modified="2016-11-02" version="1">MTGLANGTSKGDTFLFTSESVGEGHPDKIADQVSDAILDACLKDDPLSKVACETATKTGMIMVFGEITTKARLDYQKIIRNTIKDIGYDHSDKGFDYKTCNVLVAIEEQSPDIAQGLHYDEALEKLGAGDQGIMFGYATDETPEYLPLTIQLAHKLNAAMTNARKSGELPWLRPDTKTQVTVEYAHDGGAVKPLRVDTVVVSAQHSEDISTEELRKEIKEKIIKKVIPAQYLDDKTVYHIQPSGLFIIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSAAYLARWIAKSLVHAKLARRALVQLSYAIGVAEPLSLFVETYGTSDKSSAELVEIILKNFDLRPGVIVKELNLTNPIYCRTAKNGHFSDQTFTWEQPKTLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9B0</accession>
    <name>A0A1C1C9B0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_05742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9B0"/>
    <dbReference type="STRING" id="86049.A0A1C1C9B0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05742"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07705"/>
    <dbReference type="OrthoDB" id="4120917at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="3">
        <location>
            <begin position="200"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="451"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="549" mass="63040" checksum="3D2E782CE8E14BE3" modified="2016-11-02" version="1">MSTSLYDITISDRACALDHGLDGTRERNAAVARRLKQEIGEMKVGKDGQVKLQREIREHCKAKLSWCRSMRRALLQDLEVLEASEQGISSEELRENSRHLHEFEKEMWVLQFDWPRVAGIALRERLELEARMSEALTMAVATCVSDMPLSGIMDKEVWSKARNTDQAYFVRHLVRRYEAGDDRRWCPVISPLKNGKTFDQRHVKAAHIIPNCLRDVQVAHLFGLPVEDGYPKPWDPTNGLILHKEIEQALHAAAIQIVPGLTEENAQCLRVVVLDQDHSIFADDANIFDGRVLEFRPGIDARPGVEYLYVAALLAAFRRKRWDCAGWRDDYEKLFYEVPWPEDIPVDPAKSTLRALARSCGDLRRFDQYSRSSASQDDDGPNHESDAEGTRRDEWNGLLDLLNAVMSEGMKPSNAQRRDIEENPDEFWHRELAEYDNNEQQQQQGQLILDVQVLELEKQELIHVNEELARKHQAEVEELQERMAELERTCAARVVELEQTCAARVVELDRAFAARVADVEKTSSAAVIEGLRRELEKSRTTMAQLERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9G3</accession>
    <name>A0A1C1C9G3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9G3"/>
    <dbReference type="STRING" id="86049.A0A1C1C9G3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05589"/>
    <dbReference type="OrthoDB" id="3538597at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="631" mass="70727" checksum="B23BDB21DFF76BA0" modified="2016-11-02" version="1">MQEAYVEAGFCCITKRYDGGARASPQACEQVNLQVHCHGESKYLRPSIFSNKSDERVLHRDGSLQGVVVDQKYKRPDLVVGLSLTTSFVPHIGQLSPDRYSPFKDGYTCFPFLVVEAKSEKAGPGFEAIQRQSALAIRSCLKLQVDLETDSGNELLHPLVWFIGFQGDEWRLYCAIPNGDETNVVDCWHGYLAHEDQALQLLLIMDWICYWARDVYREAVLNCMTAVTSLDRGVTPAETEFSAYSDGTGDLLHGRTISLALRSPRPPLVRPGAFSQHSEASDARQMRESLDTLAEDTLMGDLSSSFEDDQGGGATNAITVIDPSDLIVEWKHLSIPEEEKELLEMIRSGLWDKSSREIASDLLEILTDDAHTLRLSRRVVRDLWDGRPESPDREFEDEEPIATLVVCRGRFDEATWQVVQSYTAITCSQDVAQQLAIAARAGKSSTLPLSYWKAHDCDCLMIAANAFQSISGRQSALFAASQEVYCLVPDDLGHPGVHCRWERYDRSQSKLLLGRIETVVNNMGHRAPELARFANRALQRYPSIDHLFDTRTIDNLPGILLKRPLLWPARGPLWCFLTFEPTHRENIEQQLSLVRDGRGIFAADDLTNEDHQSLAEAIAQMYVDTESATAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9L8</accession>
    <name>A0A1C1C9L8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">dhx8</name>
        <name evidence="16" type="ORF">CLCR_05371</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9L8"/>
    <dbReference type="STRING" id="86049.A0A1C1C9L8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05371"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07878"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="13">
        <location>
            <begin position="255"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="573"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="754"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="157"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1204"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="465"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT45224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1228" mass="137889" checksum="EA7DE0DAEC9BF205" modified="2016-11-02" version="1">MDDFTSLELLSLVSKVTSELHNHLGISDKTLAEFVIDQHEKCGGDLGKFKEALAAMGADFPNSLVESVDRLILTMHPKHKKNQRSAAQENGQSDMDELDAIGRKARVFKGLAVPDREQEWSDFEDDVTAQKAASNIRPGADEDDTFALLEGLAAKPINGTNGAAERSRKRSHSPDREDYSRDREHRRKYWSRSPSPREDKRSRRYRDEDHADRRNGHGDRYDEKRNGHHKSRRREYDDDFSMPPPQEVDEQPILYKVYDAVVNGIKDFGAFANLQGVKGSPSGLIHVSAIQEGARVNHPSDLLSRGQPVKVKVVKMENNKISLSMKEVDQVTGQDMVPSRRIASGANMERLNGLPSDDRYGNLGSSVPVLEDGYSSRPGKNKKRMTSPERWEIKQLIASGAISAADYPDIDEEYNATLNGEGQFEEEEDIDIEVREEEPPFLAGQTKQSLELSPIRVVKAPEGSLNRAAQAGTNLAKERRELKQQEAADKAAEEASKVDLNAQWQDPMIAPEQRKFASDLRQAQQQSSKAIEAVPEWKRAMQGKNQSFGKRTDMTIKQQRESLPVFKFRKQLLEAVAANQLLIVVGDTGSGKTTQVTQYLAEAGYANNGMIGCTQPRRVAAMSVAKRVSEEVGCELGKEVGYTIRFEDRTSPDTKIKYMTDGMLQREILLDPDLKRYTVIMLDEAHERTIATDVLFGLLKKTLKRRPDLKLIVTSATLDADKFSEYFNQCPIFSIPGRTFPVEIMYSREPEEDYLDAALTTVMQIHLTEPPGDILLFLTGQEEIDTSCEVLYERMKALGPSVPELVILPVYSALPSEMQTRIFDPAPPGGRKVVIATNIAETSITIDGIYYVIDPGFVKQNAYDPKLGMDSLVVTPISQAQAKQRAGRAGRTGPGKCFRLYTEAAYQSEMLPTSIPEIQRQNLSNTILMLKAMGINDLLHFDFMDPPPTNTMLTALEELYALSALDDEGLLTRLGRKMADFPMEPSLSKALIASEDMGCSEEMLTIVAMLSVQTVFYRPKEKQQQADQKKAKFNDPHGDHLTLLNVYNAWKTSRYSDPWCFENFIQKRQIGRARDVRQQLVTIMQRYKHQIVSCGRNTIKVRQALCSGFFRNSARKDPQEGYKTLIEGTPVYMHPSSALFGKPAEHVIFHTLVLTTKEYMHCATVIEPKWLVEAAPTFFKVAPTDRLSKRKKAERIQPLHNKFANGDDDWRLSAQKRQGRGGGGGTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9W6</accession>
    <name>A0A1C1C9W6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actin-related protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_05832</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9W6"/>
    <dbReference type="STRING" id="86049.A0A1C1C9W6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05832"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07918"/>
    <dbReference type="eggNOG" id="KOG0678">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421448at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="439" mass="47775" checksum="A0F7218535A02DA6" modified="2016-11-02" version="1">MAAQTPAVVMDNGTGFSKLGFAGNDAPSFVFPTAIAMKSAGGGAAGTGSGRPAVANKPSYLTGGAGPSSNLAGKRGTEDLDFFIGDEALAASAGPGYSINYPIRHGQIENWDYMERFWSNSIFKYLRVEPEDHYFLLTEPPLNPPENRENTAEIMFESFNCAGLYIAVQAVLALAASWTSSKVTDRSLTGTVIDSGDGVTHIIPVAEGYVIGSSIKSIPIAGRDITYFVQSLLRDRGEADSSLKTAERVKEEYCYVCPDIVKEFARYDKEPDRFLKHTVTQPNGRTLTIDVGYERFLAPEIFFNPEIYSSDFLTPLPTVVDGVIQSSPIDVRRGLYKNIVLSGGSTLYKDFGRRLQRDIRHLVDARIRASEARSGGAKSGGLDVQVVTHKRQRHGPWFGGSLLGQTPEFRSYCHTKAEYDEIGPSIVRRFALLGGPGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA66</accession>
    <name>A0A1C1CA66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">pH-response regulator protein palH/RIM21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">palH</name>
        <name evidence="8" type="ORF">CLCR_05468</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the palH/RIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA66"/>
    <dbReference type="STRING" id="86049.A0A1C1CA66"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05468"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08051"/>
    <dbReference type="eggNOG" id="ENOG502QWMT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5393256at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014844">
        <property type="entry name" value="PalH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH/RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH_RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08733">
        <property type="entry name" value="PalH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="485"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="542"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="620"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="724"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="798"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="843" mass="90942" checksum="AA69F9ACB30A2932" modified="2016-11-02" version="1">MSNDASITVRQLWGQLSTPAASHTVPEAWCTPLILPSGGIFIFEDDTTTTLRARVTFKLPCDNPNPIISPDTTGNSSVVGFSNPFYASISPQIFALATATVISYILVILIFITPRTFYLGGPGGGTRFLGRRGIIPGSYGSSSVVGVGRRPLLQKIATVTVAISLTIATADTFNVAERQYNQGYIDSSQLVDNVVDSLEIRIIRVISDTFLWLAQVQTLIRLFPRHKEKVTIKWLGFAMVSFDTIFSILDSFVSGSPRTRPRSFSDAIPALNYLFELAISLIYASCVVYYCLSKRRFAFWHPKMKNICLVALLSLISVVIPVVFFILDISQPDLAGWGEYIRWVGAAAASVVVWEWVERIESLERDERKDGILGREIFDGDEMLDMTPSEDASWRGDLGPDHGSGGGKGMGERMASQYRRVRGRLPLRKRRKRVPSDGITTGADAMGTAGHAISGSQFVIPQQTTTPPNRSDTGSATSTVYAVRYHNPASPPPNPQPELRREGGGHTSGDAPKDSDDSSSSPAGADKELALQTVARTVTAPQGRNLWQAVQNPFKRRRSEPPAEVADAQNASGVRRSPIDRTLNLRDRLGAFASTQRERFGARGNTAATSLPITVIPAPRTNERTWSPDDVQGIPTEEGPVRMANTDPALPGQAFYGREQVPGQVVFIPAPTNGRTWSPDDAHLDVPSTPVPVRPDAVALRHPASSFGQTHSPQQIYTPRGSLIISESDPRPSRVIDASHPTSPRSATYARPPAVAPIAEDASNEAGSEIPTQVPVTSPAAPAPAPSSGDAEREPPVSGNTRHSSSRSVQTAQAPRDSSHNLTNAEATESDGRDTGGTGSTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAR3</accession>
    <name>A0A1C1CAR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosome biogenesis protein BRX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BRX1</name>
        <name evidence="7" type="ORF">CLCR_01624</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAR3"/>
    <dbReference type="STRING" id="86049.A0A1C1CAR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01624"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03461"/>
    <dbReference type="eggNOG" id="KOG2971">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000464">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000465">
        <property type="term" value="P:exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="61"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT45551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="337" mass="37039" checksum="29A407348C2E63A5" modified="2016-11-02" version="1">MASAYRSALRSGSDSDSDEPGSETSAASSNTVRAESSSEEGKAAQQTKSNGLSQLPSEIRNRILMLTSRGVSYRHRHLLNDLHSLLPHTYKDTKLDTKSSGNYNSALNALADLNSCNYIFFLEARKRGQDLYLWLAHAPNGPTVKFSVTNVHTMAELGFGGNCLKGGRGIVVFDKSFDEEIPGQEYRSLLREMFRGVFCVPPKGVRGMKPFVDRVIGIYGLDGKIWIRVYEIRENDPRTADKAQANGGDMSLVEIGPRFVLTPVVILEGSFGGPVIFENKQFVSPNALRAETRARRANKYASRRGGAEDLAVKRKTLGLNTGSKRKRLATDNATLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAS2</accession>
    <name>A0A1C1CAS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Low temperature requirement A protein(LtrA)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAS2"/>
    <dbReference type="STRING" id="86049.A0A1C1CAS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01429"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03472"/>
    <dbReference type="eggNOG" id="ENOG502RZXZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840:SF1">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="737" mass="83818" checksum="02612CE191412535" modified="2016-11-02" version="1">MESVPEPDLEKGGTTSPKTHEHHHLPFHHDHSHHSHRGRRFLEFVHPHTGKTLVVCQSPEQLERRRTELRQEKSDHEFDVILQGSAQHIEAIRDLHAHHEAKRDQLREQHGDLYADIEHVKSELDALAAEIHHVTAHAVSLDASFDRYGYSAHLRTTDDDSEKSSIHSDHPSAQDKHKDRSVEAIQFFRRPTVRQYFHKGLLWRSSRAGEVGSFELFVDLVYVGVIDIVGEKAAEHPDGLSLLQFVIIFCIAWKIWADLTMWINYFEMDDIFQRICVIFYLICLFGFTTNIFYAFDSTYTSCIAFYVTQRLFAATWFAAVALILRQVRGAMMMTAIINVVTAAVWIASIHVAWPGQLAPIVVAIFMDLFGNVLLIGTMKAAAKKRLPDVIARAFEFFPAINIEHRVERNNAFVSLVGRTPLLSACTEIDRDAQVFGYSILTILFQSRASFGINAFFGKGVLGLIQAFMFNWIYFEIDAYHVHVHAIRRHWLSASAWVTAHLPFIMGYVLAASTLSRLVLAHDCPDADAHDLGEHYEENSEAEVSHGLRWFYCGGLGIALISMALISFCHIHKRLENPRLRKRPRLVVRLCVAAIIICLPTAESLNSLHLISITTALVFVVLCLDLYGMSCDVSFSPQVGFRSGRISLPPDFPPSYTLRMLTVKQGDRFFSGGWCEESKKNCTYSAKCKLGRRRRQELEEALRKGQKVSLTDLLKRHSSMSSLESQDSRDEEWHGGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBC7</accession>
    <name>A0A1C1CBC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBC7"/>
    <dbReference type="STRING" id="86049.A0A1C1CBC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01464"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03736"/>
    <dbReference type="eggNOG" id="ENOG502RVGM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF11">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="302"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="552" mass="58973" checksum="085FD1D8E00CCA85" modified="2016-11-02" version="1">MAEAGLAERLDVAIAEFFASWNIWTTVLALVLVAFLVYPVLTGTDPDTHPFLLARQAQIAPIRQSGESAVYRAIDIPHGYPLRAGLGVKDPGTPKWSSGRPGDLRDVWRNAARGAVNEEGNPTGEKGKILTVLGREKVIEHDPDDLTLGINVIGQYVKRNNGQSVAVCLSNSVELLSAIFAGSFYGFSTVLLPYGLTQDKLNSLLAKTSADHVIAEAGSLDLDDLASTAKSIKTVIWVTRSTNEHMNWTEGTPDGYSVTSWHELVEKNRRSAKSEVLPLDKDSQVPPVSVFVPTANGGYDLVKYTSENLISATAALLATLPRAHKISPSDTLLPTTPLTDSYTLSWTFAALFSNATLSLNSVAGDNIDIVHATSQSSPTMVLASPATVTTYLKNPDTKLPGGLGKFMAQRTLQQGNMPAKQSSSTSPLSHVRVLLIPQSTTSPASTRLSSSTLHTLRTLLKCRIGYALTAPQVAGAIAQTNIFDYREKGDKVVGVGAPLSSVEVHLSGEEDVMGTRSPRGTMTVKGPAVVGGKTTIEGLQVQIDEDHTLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBD2</accession>
    <name>A0A1C1CBD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4048 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_01537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01537"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03678"/>
    <dbReference type="eggNOG" id="ENOG502S19N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4097086at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025122">
        <property type="entry name" value="DUF4048"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13257">
        <property type="entry name" value="DUF4048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4048" evidence="3">
        <location>
            <begin position="222"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="515" mass="56526" checksum="B5D20E88981C81FD" modified="2016-11-02" version="1">MEHTSPCETLQHSHRPDGSPLVGDDTAIPPSPSRAPATKSDAPKKHTKGLSLNFPILLPTNLQLSQSPGGSAVPSPIESSRSSPRIRAAPFTSPDPATQPPDKNKARGSGEFLTLLAAQERKVLELKEELQRAEADLQILKKQWAAYEASKKRDEVRQVKKLQPRALDDVAGSETLAPEEDVDEERRRKRALVERNYTSHTTNGGSGLSRKGSKRIFEGGRHTRTLSLLSPTCVNPSIKPAEDTNPTPNDTAELETEHDQKPSLSRMPTLDGLISADALPLGFGKTYKDLAAHRRSLPPVAADMLVKQGRHVYDGVREGLWTFFEDIRQATVGDEGINGTAAQQRPVRPNQHRPTRKPSVKGDKGTAKETLDTSTPRSKEKSFWNEFGLDTPQRNSSTSSKPPEKPNGHVQQKSSTDSSNPPSLLPDLNDNDEVEDSWDAWDSPVGNKVSNRAPNDEASNTTSGGLPWPEMQRVTPKLTRTISDLMKEWDSNQNDSADMNGTREGQTHILDSPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBD3</accession>
    <name>A0A1C1CBD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BZIP transcription factor HapX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_01554</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBD3"/>
    <dbReference type="STRING" id="86049.A0A1C1CBD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01554"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03750"/>
    <dbReference type="eggNOG" id="ENOG502QUE5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5374328at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT45860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="495" mass="52144" checksum="FEE5AE68922AFA11" modified="2016-11-02" version="1">MASKAASPMAASPGAAQVDVKPTITRQPSLCMKPAQTPPACSPPAAASSAPLSLTTKEWVVPPRPKPGRKPATDTPPTKRKAQNRAAQRAFRERRAARVGELEETLKQIEEENEHEQEVLRATVDKLGKELEQCRTDLTLWIDRCRKLESELAAFKKPTSTSKPTTSTQDKSDPAASDTSIGCGNCTLETRCQCIDDAFAAMSGNSASVHQHEKRPHSPSHTSVTDKRIKLEPRECLEIDFTGIYTSSKSPATAAGREENNSPTSAVADPCGFCSDGTPCICAEVAAEQEQQQAQSNATAVSSISRAAARQLDQFTPPPSEGDVSMPVSATAAEGTSGCGASGPGTCAQCRADPNSTLFCKSLAASRAQSTATSSGCCGAQTPGSSCCRATSTSVVALRGSTRTTRSRAAAVTLPLPQSVQHAPSGVTLTCADAYTTLSRHPAYERAAGEIGEWLPKLHATEPGTNVEGRPALEIDAANVMAVLRDFDRRFGKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBL2</accession>
    <name>A0A1C1CBL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBL2"/>
    <dbReference type="STRING" id="86049.A0A1C1CBL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01645"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03744"/>
    <dbReference type="eggNOG" id="ENOG502RK0Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF60">
        <property type="entry name" value="III CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="1">
        <location>
            <begin position="19"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="330" mass="36691" checksum="B961A8576D674796" modified="2016-11-02" version="1">MPPVPVPVPTAPGLAAFKPRIVCYQQTYHHPDDNNEYCSLLPLLTNPSGITHVILAALHVNWEPGNVTLNDDAATHAKYTQLWDEVLVLQDSGIKVLGMLGGAARGTFARLDYSESRTDVPLARFEAYYAPLRDVIRRHALDGLDLDVEEEMSLPGVVHLIDRLRADFGPAFLITLAPVATALMAGRRHLSGFDYRLLETLRGSHISWYNVQFYNGWGGLHSTDAYDEIMRNGWDARRVVAGMLTNPKHGGSGYVPLELTAAVLSLLVERYPRFGGVMGWEYWDALPQEGGDRAWMWAYCMGLCMGMKKVRDVAMVVQLGRGLASVRVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCI9</accession>
    <name>A0A1C1CCI9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_01078</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCI9"/>
    <dbReference type="STRING" id="86049.A0A1C1CCI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01078"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09342"/>
    <dbReference type="eggNOG" id="KOG1505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="127"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="668"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="668"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="763"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="804"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="878" mass="95015" checksum="5F1A4838159C174A" modified="2016-11-02" version="1">MAASKTPALEPAAGFSLESRPKRPDRVPLAKGEYSVASRALGLATYFLSGALAINISQFLGSPLKSINEDWYNAWIAFTKQSFGLLTMTLTQTFAPTKVIVSGDESVRGQLLKSADGNLILDFPERLVLIANHQIYTDWLYLWWIAYCNGMHGRLYIILKESLRKIPILGWGMQLNQFIFLKRNWEEDKPNMARSLQKLNKPTDPMWLLLFPEGTNLAPSTREKSAAWAKKNHISDCRHTLLPRSTGLHFCLDELKGSVEYVYDVTVVYAGVPRGQYAQDIFTLKAGYMEGRPPKSVHMHFRRFAVKDIPLHDDRAFELWLRARWREKDVMIEEYYQTGKLPADYGGTRYKSGKVLRGCGHMEVPIRASHWYEFLQIFAPMGILAMILYIFYGDLPQRFWKNINKQALQAGTQDLRKAGAQAGEGVKSAGSSLGGLTLDDFFQPGKQEETFKAGAMAVQRLITSPQAQTLLNRADFMQAFLSDPQKMVTDTITDKQQSFMQQLAQEEAKRQHSNVAPPAGTGFVRPIPSRSSSAATGTGTVKGPPSARKGDFYNQLNAEERNRAGSVTSHPAKKATFYDSLKAEEQNRRGSVVSVPASTNCVKQSNGRGAGTFWQDLKDAEVKRIASAPAAKMPLTSKNLASKGTFWDEVKKEENTRKGTVVTLSSNATTAVASQSSKSSSTSSQRAPPKLSPKKAGASAVKRNEPNVAKGQKAVPKASNGAQNAVQKPTISVPASGPSMKKPGPVAISTAAGKKGTSSPGVKQSGAKPSSASASAPASAAKPLPKSTANTGTPKPLAPIKKQPATATATATATPASKVTAQKKPATTPATKVSTQQTQKATPPKGPSKTTKSTGPAVKKPPATNAAGPPKLKPTAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCW1</accession>
    <name>A0A1C1CCW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ataxin-10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCW1"/>
    <dbReference type="STRING" id="86049.A0A1C1CCW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01349"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09224"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="118" mass="13062" checksum="7636BDD419C9BD50" modified="2016-11-02" version="1">MCLKFLLENNPENQALVSSLEAREVVAPPDPGDAMSITEALDKLGMDVALMPDGRAKVIRREGGKSRLRRTPQGRLEELREEVETLGLPVNKEETVEKGKGKERAKEAEGDDGEIEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCW7</accession>
    <name>A0A1C1CCW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_01031</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCW7"/>
    <dbReference type="STRING" id="86049.A0A1C1CCW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01031"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09209"/>
    <dbReference type="eggNOG" id="KOG1609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1108038at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000287">
        <property type="entry name" value="RING finger membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="706"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="756"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="935"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="979"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1029"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1091"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1131"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1275"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1315"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1356"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1420"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1486"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1519"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="15">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="316"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT46322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1584" mass="176354" checksum="DD703EC7032C90F7" modified="2016-11-02" version="1">MSLNPLEDSRPAGQVQETMLRRSEPNEEEQNYCRICRGEGTVAQPLYYPCKCSGSIKFVHQECLMEWLSHSQKKYCELCKTSFRFTKLYDRSMPARLPFPLFVRKLARHGIREFARWTRYLLVAIIWTCCLPWCIRQVWRGFLWLADGSTPSHPSTETAAVAVSNTSATGSAVRASQTQFANVTVPDYLERITLVFPPMLISLGDVARVIVGQGFIGRIVGFILAIFIPRLRQVEGTGNGQDLADEAAAMSPRPPSLLSDVEFLSAWSGSRMVNNATLDIIEGQLICILLVTAFILVFLIREWVINQQPILNMPDPDAIDNPLQERQAENERPRVGLLRPRNRRQGGDANPPAEGGVMDPAARPIAIPRRRRALTDDNILNDTGIGIERPAPPVRSQSLLTSPDDIGQANVEEAAGESSAVADNTEGQPVRRRSSSSHHTTEDSSVTALGVQTMDAGNLDSSSIGAQGTLPLDFAFRGSEAVRLQPDSLQHMEPNERDLPEPLGRTVSFAQTPDVIDEIAIPPGHVDAHEIATDSDGQVIPTPDSSNDTDFLHPGGEFLDTDLQEDLFDSVPGIDAEELAVPIDQEPTADESLIGRISKWLWHTDVELDTPEVAEVRDSPHADTQDEEHIVEDVNVEAPFVPVHNREAPQIPQLPPAPEARPAEPREPNMFMGVDLNDAGDDAEDLDGVLELLGMEGPIFGMVQNVLFSFLLITITLTMSFWFPYMWGKIALLFLSQPTLMLVRAPLFVLSRSADIVVDVIFFVVGLTGFLFSQPMKLMRALISGLAPSLGRILDTATIEGFTLDLSQKSGTRLERTLAAAVLGLRPDVPNFSMQSHHALISLKSHLRKALHGTAFLVAQIEKALTSDRPSSGTILASFQQSLKSAPEVFKKLPRVRDLGSNFVNLLYHDLWTEPTQSVHDLDPSLAEWNNQDRILAIILGYALFAVAGVVFLEVAHLVLGLKDNEKVEGYFADSLRQAGGVMKVIVIIGIEMLVFPLYCGLLLDLALLPLFANATVASRVAFMTQTPLTGIFIHWFIGTCYMFHFALFVSICRKIMRKGVLYFIRDPDDPTFHPVRDVLERPVPAQLGKIAFSALVYGGLVTLCLGGVVWTLDWVGGVLPIRWSTPEPRLAFPIDIVFYNFLLPFILRKAEPSKKISAMYKWWFRGCARSLRLTNFLFGEERKDEQYTHPRGFPWRLFAHDGITEPQRDGTYVRAPASDSVRIAKGRNVFLEVTEQNERVDGRPDTDFGMHGKKDPQFTKVYLPPNFRSRITTFIALLWLFAAATGVTFTIGPLLVGRKLTQRLSQSQHPPNDLYAFTVGVHIFAAAGYAIAYARPARDYLAAKVTSSGKQILGSILHFLGLAYLSIFTTIVLPFVMALITELYIHMPLFDVLELVNQEKAQDTSASGSTSTPTDRKRLPGATIFILQSWTIGLLYLKLLLRVLTHATEPTSRPARALRAITRNGILHADVPLASRAFVLPTTMACLALLLCPLTFMKLVITVFRVHETEKQMRMYRFAYPLFLWMMVNYVGAMFMKTKVEKWRVMVRDEVYLLGERLHNFQEPKPRVRNVDASSSKGKGKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCZ9</accession>
    <name>A0A1C1CCZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCZ9"/>
    <dbReference type="STRING" id="86049.A0A1C1CCZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01285"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09201"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09202"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="229" mass="26713" checksum="F730711C796ADFB2" modified="2016-11-02" version="1">MPDIRAQLTFLSNSPLYEIEKPYSILLPEQEQGDSIRHDLPRCNNLEWSHHWVDIREARRRHDLTLEACGFQLLRHTSQSIPIREPRDVTSYRLETEELLQTTFAAERAICYDVVLRQNVRDTSSSTDLRDPMSPHPPAFRVHNDATPKSGVDMIERHLPHEIREMYPVTRYRYRIVKYKTTYGLGVDSPLAVCDYRSIADGDLVAVDKVTPSRVGEVYYLKHNDHQAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDD5</accession>
    <name>A0A1C1CDD5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_02087</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDD5"/>
    <dbReference type="STRING" id="86049.A0A1C1CDD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02087"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01198"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT46466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="248" mass="27727" checksum="71F704F7B0D57ADC" modified="2016-11-02" version="1">MSEKPPYIVPPTADTSSTARPATLIFLHGYGDDADGLPLGLAQQFQFYNKMQYLKWVLPYAPHNHEAMTRAWYVPRALPNAMKPRVPGEVAEEDAPDDEAGIMRSVDVLDQLVEQEIENGTPPERILVGGFSQGCAVSLVWGLTGRLRNKVAGVLCLSGYLPLRDRIAELRNERAVGANEKDAKQWFYVHGTMDMLVPLKMFVQGNEDLIKWVDRENIDGHVYQGMGHSTNSAELRDMLAFFEKVIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDH6</accession>
    <name>A0A1C1CDH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_01907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDH6"/>
    <dbReference type="STRING" id="86049.A0A1C1CDH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01907"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01261"/>
    <dbReference type="eggNOG" id="ENOG502S1WE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="722566at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045048">
        <property type="entry name" value="FBXO31/39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706">
        <property type="entry name" value="F-BOX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706:SF130">
        <property type="entry name" value="F-BOX ONLY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12014">
        <property type="entry name" value="Cyclin_D1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="505"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="533" mass="60418" checksum="7AF679378FE35BD7" modified="2016-11-02" version="1">MGLFKRRTIDTMDEAERRKMFVPDGTDATVSINYAVDQQDTLLLQLPSEILHQILCYLPPQSLVSLARTCRQLRGLASNDLLWANLLRPNIPPEDFPANPYPSSSFRDLYITHHPYWFVPRSRIWISDEPHIGRVMIAHYDPRRGCIEGYRLLAERTPGVAIFWPYEASVVIHSFRPRVHLWLDDPIMKLPHDIVPFNTRQGWWEAEVKMSVGRPGHNTSASFFLARNIPAHVESPSMALWPPRTIPNMPRVRAESADRFRGSGHKPQKYDQISQTAFRLRHWSQFSTGMAHFGIRIGEEVSTWSTIDPTLYTPTREKPYQGIYVGDYAGHGCEFLLVMQREQPPVLPARRPTDAFLRSLIGLPPVGEDAELDEPLLEQRPGSPTSEYQRTVLAAQVAEGIYHGAIEAVKLTGDPNIPRGEYTFVADDIGPGGLIRIAEEYPFKGARVVRSRGHVAARGFQNDEFIPSQLIMISPNKLAQYWVPYGHISFYERVNLDELIDDTFRGGGMQRENEQKGGGARQANGESSEASEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDP5</accession>
    <name>A0A1C1CDP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02005"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01368"/>
    <dbReference type="eggNOG" id="ENOG502S1DF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5407645at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="377" mass="42298" checksum="A3A7D80466B82DFC" modified="2016-11-02" version="1">MDQAIGIGLNGVNLALTHQEKVLDPLHRKYKKMRGQGPQRDPDLYDRRTMEEKGLVLRRRRDVGSDEEIVEVVRHRGEILPRRPGRPGQQRRSSSMNNARTVGAAGAGAGAGALVAYNRGRDRDHHRDSYYDSEGSVPPRSRVRAKSSAGRSRRKRSSSSSSSSSSSSSLVSSTEEEKNISKMQRKKWITAALASVATIHAASKVYSSIESHDKRMEKVREGKLSPEEAHKQQRASRWQDAAAIGIAALGIKGAVSEWNEVSEEHSQHKELLSQKEEHHKRRLERERRSRAREHGGYYKGRDGRWYYDGPVPQSSESYRGGGSGAGGHYDDRLAIKDSNRARDIYEEAGGVSPDYDDTRSRHSRSRRAVSRGRESDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE50</accession>
    <name>A0A1C1CE50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE50"/>
    <dbReference type="STRING" id="86049.A0A1C1CE50"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01789"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01454"/>
    <dbReference type="eggNOG" id="ENOG502RNS8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4156635at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1300"/>
            <end position="1314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1321" mass="147806" checksum="E850CD88BF3FDA35" modified="2016-11-02" version="1">MAPRTYAARRKIQAYRASKPASSAYVHTRVGRPAHRPKTHGTVTQLETIAPLTPPPSRDSPSSRIKLHLNPAEKPNLPEDLAALRRTVNDRHANDVSHARSIPLRRAVSPGLELADIDHASSPEDVENIIEQITDYFDFWSNTTLEEGPASLLADFRLINRRLGLALGLFEDVTSSYICGRAKRDFHGIYARFVETWSRATYQALVDKLDRLQAQLRARITHRFTAIHEIEFTLFDLDVGVVSPCSSLQALLGSTCNTVPFLVSADQAEELVDRAEQLLFAFQDVTYDTEAKELWLLIWRSLKRVFAAFDQGGAPTSPTNTSRDRLFFEIPKVRRELKRLNYTTEAANPTSIESIVGEYCRYIHSCQIDPGNKYESLQRTQDTPLGQHTKNALRQFIKTGKFETSTLSKLHFAVARFNKINGGPVMVSRWRSPHDNGVWDMIPMYLDSPVSVQASSATEDRANVQHTSQPSSPMNSHSPALDISGGVTEKPAKRVFPYPEGINIKSDFDYVWYPSPETRAHEVVQNEQISRELAQPGIVSAGPRPEYLINRPPRHVRDPTQFAERSLGPLSFIRHAIQQLIAKKRGLPDIRTPTFSRLPMHQQSLPVESASAILGRKARVQKPVPSGQLSGLRGGKGRPLHWSTGLSRRHHFDAAAFHRKMVSLSIRELRRRYGGEIAIDVAEILKLLPRTGYDIQEVAMRYISRGRGPRLSPISTSHGNSGTRPSDQTAAAGQSKHLPPVYERCMDEHAGVSKYRVNNSPRATVEGWEEAYLNEHHETNEDDDQENLPPGPAGVRIPLGEMQPGDYPAPQSDGSSLPRRSESSDTPVRLRCHPCPTFEGQYHHECPGSRFCPGYEPPSPAWSPTSPSYPFDYDRDNGAGRWSSEDEHRYSSDDEQRHEQDNGRGLPVDNKSEDSLIIYEDDDQAGGPDAGHNGDEAGHEDYRSQGENATTPSAAPAAEDDDTVESLFGDQEGGFATVIGRLAMDSFVHIQQGFDSLDQGEINSTTGGEVVGNMMPWLESTAAVINQLRGEYLASLKGEQKPHLEMIPEEEFRSKPSIKTHPATYKLCKRAFQDVRFHHGRVLQFFDYTHPRTLLSFRYAFNALIVAVRELLLLLREYHRSLVGPGIDTGDERGDDDNQPTYPPRSPSNDSVVTPPISKVGYFQSPVHKDVQKPHEQVKNAPSGPRPNPLPARKDYENMFVPELCRELEQNRGIDDVRGALGKKNPVKKDYIDKLMALDQEGIVGKGATECYRNITGNWNARGTPKNWDIETALRGYYERLAREEEAMSLPRGSQRTSQRGKSGSKSLNGSSRSVRNGPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEJ7</accession>
    <name>A0A1C1CEJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEJ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CEJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02288"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04706"/>
    <dbReference type="OrthoDB" id="2922289at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF2">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="790" mass="88993" checksum="9EAEA994E0824145" modified="2016-11-02" version="1">MDSGKTSTIVLGLPSARSTGHIRQMSATYSKGIFSCWGALRDILACREELIRKRWMKKTREQRKLILLSAWPEMPERHRPDFHELEKKKRGVKSIDTSALKWPYISQEDLLQGKLLLLFLNSRGRSPPSTFAHTDLGSTLLRQTGGINVPVLLRNHTMYIAGETKPENYGRLVSWSDDDSARILEQSGLQFSPGRGLLLLEIQTKVYSFLLECCYQLLHDVPRDELANLQLSEQPEPPAIGGPETSYTRISAVTAEAPYRLPAKLDTDRLVRILEARRAAAEDHLWDLREDPGYFAAAVVEESQHRREALLGVDGRRHRHDCDEFFWNRVIGETVSNAYMTFLTWDVLYNYTVALDQELRVGGDLDPRKPLPKRLETALVELSFAAGSSAQVISGTLNVGLPASPPIRDLFERQPQHEGSIKGKVDVVPKKGACKDPLLKLFVSLSDNEQLLLLRLPNVVDEMQRLIDIDAGQRARMTPWVARYFSDLALAAHIVRQVDNFYPWAAGFNELMNPEIRAPAFEKAREDLKTVYYTLNDRLLPRLSRIVVPFQENLHYPIDRAYDAENVDACRQAEAHLAKLWKTLDAHFVKHVNRTLHDIFLKHSVLARNIRYTPKLDSSAPEHSQTPGASDPVEDGSPKPNIDAEKPSVPVAAEISGSETNGGDTPQSPEQVPAIEPPNERPDANKMPTFNLGKRAGKVFSTIFHAPSENEQVGEISWVDFLHAMTAVGFVAERLYGSAWHFTPSKLGSKTSILIHEPHPSEKITSTMARHLRKRLSRTYGLTAESFKMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFP8</accession>
    <name>A0A1C1CFP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02658"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="142" mass="16489" checksum="A663FBC67561264B" modified="2016-11-02" version="1">MDTHEFQFMPQARVFKPPRKEQNADLIAWWCLLRTSKFLTPDFQVLMLMHLLMLMLMLTLMLTLMLTLMLTLMLTLIPHLHPRPSRCYLFGTRGLEISITRRIGTLLDYSELGNPTAQGPDKDPDKIQPSGILTYYILHTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGJ3</accession>
    <name>A0A1C1CGJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03595"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10398"/>
    <dbReference type="eggNOG" id="ENOG502S5DH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4510061at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="282" mass="31748" checksum="E3953D10AF5843DD" modified="2016-11-02" version="1">MLSSPRPEYLSSSQASNIGQVERPIRDLDHPSLKELDTVAQHLFHTKERPIGSAPSVESLLLNHPTSSDLANSPLAMADGLNEARAMRVMELMNDFRTLQIHITSLITRSEANPPDQQSYYLDGYVVLRQCAAESQAVLAGHFNPGSLGIQAGNVPETEVQKATLQRCDSSSLSGLAARTDTLHRIILDASTRRFQAHKIYLRASAAMRWVQMRAQVLRGEKPAAKHVNALRAVDQRLRQELNEVTDDHVVRDLRNADRRKGYWIDEDPTLERMLGWIRMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGM4</accession>
    <name>A0A1C1CGM4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">N-acetyltransferase ECO1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_03459</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Noorani M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGM4"/>
    <dbReference type="STRING" id="86049.A0A1C1CGM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03459"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10385"/>
    <dbReference type="eggNOG" id="KOG3014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="11">
        <location>
            <begin position="218"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="12">
        <location>
            <begin position="436"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="378"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT47659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="508" mass="56301" checksum="F1692168490C1199" modified="2016-11-02" version="1">MSPVVYPYLVTNSYKGRNVRRAWDGEDYRPPKRLRLNDTWNATSSSAPTINENSLHPLDLEDSLERAIRETSVAALSSSPSRKNSTIFSAAESQADELGSSTITPPSSPPPELQLTPPNVKVRKPTFACLNKLNKDKKDAKPAKRKREEQSRGLSAPVSTRLDSEPLSEIFNSSLRAQSSQPPTNPDPPQQDVERTAIARPTIQIPRPAPPPKQKLVQTVLDLGQPLLPATCPQCQMSYMPSVPEDAQLHNMYHNRDSSGIELGKPFLKSAMRWCYQVPQIPGSVIVVDRKMALPTRRVVQKVLGIVNKELGSVDIKEEELWSQRVPEGEKDEELGGKKCDRYKAFLHILDEKCVGICLAERITKAHRVLPSETATSETLPLNGHFGCKRPASPTPTETHEEDQRSISHKPQIPTPVASPTASSPPSSICISEETYPAVVGVSRIWTSKAFRHKGIANNLLECVMNQFIYGLELEPLQLAFSQPTESGAALARAWFGEKDGWAVYRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHN6</accession>
    <name>A0A1C1CHN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04084"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08197"/>
    <dbReference type="eggNOG" id="ENOG502R1F4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4021778at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="492" mass="55217" checksum="673105598449B1F2" modified="2016-11-02" version="1">MAIERRAPRVNLAPLKPMLRAYGLAYLFTTGPRIFAFLRRVRRSHLTLQEQLAVFRKILITSLQLNRFPTAAAVLIGGATTFPRLVSAILRWTIVTLTRQNPLHLSKNGNLYLRASCSFLSAWLAFGLLNRDEDWTRKRAESRAAAVADNSTVHVANQRDLPFTSRRPSYAGKTIDFTAFAFCRALDIMVISAWSRTRARSWHPEQRTPWLANLLGKTADPSIFAMSAAVIMWSWFYAPERLPRAYNHWVSKAADIDPRLIQALRLARQGSFVYGEDTGQAPLLAGLCRDLGLPEEYGDPARTIPIPCELYHCGSGKSCEVHALSRLCRSWEFAMEIYVPLQVLALLRAPSKKSILDGLRNAAISSSFLASFVASFYYAVCLARTRLGPKIVPYKTITPQMWDSGLCVLAGCIACGWSILLENPKRRQEIAFFVAPRALATLIPRVYEKRYQRREQVVFAASVAVVLTTLKSNQKQNVRGVLGRLLGGIMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHR5</accession>
    <name>A0A1C1CHR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_04411</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHR5"/>
    <dbReference type="STRING" id="86049.A0A1C1CHR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04411"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08172"/>
    <dbReference type="eggNOG" id="KOG4116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6683853at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.210:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT48007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="110" mass="12616" checksum="A62C5A44457604A7" modified="2016-11-02" version="1">MRPTPALRLQATRILRGGHGPDPKNGVYMGWWGSLGSPTQKNIVTYSMSANRLNPTHHVLYDAVFNTFRRTRNQILYWVPPLLVAYLAMDWAIERNEYLNSKPGRAEFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI23</accession>
    <name>A0A1C1CI23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_04015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI23"/>
    <dbReference type="STRING" id="86049.A0A1C1CI23"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04015"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08333"/>
    <dbReference type="eggNOG" id="ENOG502SID0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="143"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT48184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="520" mass="57894" checksum="B6A40E79ECAB9C3C" modified="2016-11-02" version="1">MQTRRLKRKCNRELPSCGLCLRLGKPCGYPLKQQQDTADDTDFLLQKIQQLEHRLEVAQSGTAAGVVGVLTPSSASRASLLSGDPSNRLLAATGLVSFPKAIVLDTDLFTPLPRPGMHGNIAWNTPREVVDVLGFDVEAICEKYFASAYKWFSMLSRKRLAQSLARSSSSEWHPAVALLLLCMKLLTEPLQAHDAPEMPLYQLTRQYLSAIENAGSINLLLVQAIILTAIYELGHAIHPAAYLSISRAARIGHLLGLHDKDHATQMFETPETWTLCEEERRTWWAVVILDRYVQCGMTGVPLATCEPLQGELLPCNDNDWSQGLVGSNDPLFTASPSLATPGISFATLCRSSHMLGRVLRHKSDHILEFPDKLAEAFQLHRALQSLERSFTCEATREELKTCDLPRAVVCTARFILYNIYACNERYSAYKLGQETDMQKIAVEGLSTAALTVAQIAQRFEQDYEMGVRGHPPLLAHCMYQALGECAWFVREDPSPQMQCAFDTIATALKCMAHQWRVCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIP0</accession>
    <name>A0A1C1CIP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04396"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08446"/>
    <dbReference type="OrthoDB" id="4158707at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="166" mass="18418" checksum="3768CCC892C8386B" modified="2016-11-02" version="1">MKPPPFFPSRLVFYRYLGLLFVVALLSTPVLMPIPIPIPIPARVHALPIQDSLTLDAIDASVLESLALAYTAYLEKKQQGTTQLLDTVDDFIESAKSALDTDFELTRAMLVEVVDLLRRSNDAQSEGNQVARRNADVQKRSLAIQERTLQLAEQSNRGAVEQIITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIR5</accession>
    <name>A0A1C1CIR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ZIP Zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_04113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIR5"/>
    <dbReference type="STRING" id="86049.A0A1C1CIR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04113"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08495"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="438" mass="46184" checksum="97776C2BC1B8547C" modified="2016-11-02" version="1">MTMTSSGQTTAVTGCIMHDSQVVCTNGNGEEVLVEATVTAEPPAQYTGCHSHGEEQFCIGSDGDEVLVLLADAHSDEHENHNDPEETGSEGEDCHFHAGVEHCVGPGESESSTESPQSCNVRMRDYDIPLRVGTLFAILVTSSIGVFGPIFLNHLPFGAVRGIALSIMKQFGTGVIVSTALVHLYTHASLMFANECLGRLSYEATTSAVVMAGIFLAFIVEYVSHRILLSRAQSSNGTAASQAASRQPPSPDKTGPQPGLATYADHHLPPSGLNPNTYLSVLVMEAGILFHSILIGLTLVVAADSYFITLFIVIVFHQFFEGVALGSRIAVLSGSRRPLIHKLLMAAAFALITPLGMAIGLGVLNHFNGNDPSTIVAIGTLDALSAGILLWVGVVDMWARDWVVVGGELVDAGFGKVLCAGLSLVSGMVLMGVLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIS8</accession>
    <name>A0A1C1CIS8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucan 1,3-beta-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIS8"/>
    <dbReference type="STRING" id="86049.A0A1C1CIS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04170"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08549"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39644" checksum="09F7D1C39115B694" modified="2016-11-02" version="1">MQALFDLAHQTGKVVYFDKGAYIVTSTINVPNDLKVTGELLSIIMATGPYFGDEFNPKVVWKIGNPGETGTVEISDLMFETRGPCPGAIIIEWNIKAAGPALAGMWDAHWRIGGTAGTDLQQDKCLKTPATPIAGNNPVLTQCLGAFLLLHVTPQADGYFENTWGWVADHELDLDDRQQIYIFNKAGFLIESAEGPVWLYGTAAEHSVMYDYQFVNAKNVFMGHIQHETAYFQGNPNALVPFTPQASWHDPDFSDCTKANCARTWAVRFVNSSSIFMYGGGLYNFFENWNTQACLGTESCQERMVDFRNSTDIYLWALSTKGSQFMVSYEGTSVVPYSVNRANFCETVALFELASEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIY8</accession>
    <name>A0A1C1CIY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HBS1L</name>
        <name evidence="14" type="ORF">CLCR_03936</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIY8"/>
    <dbReference type="STRING" id="86049.A0A1C1CIY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03936"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08619"/>
    <dbReference type="eggNOG" id="KOG0458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="235"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="53"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT48494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="645" mass="70136" checksum="29A8517031B00D4B" modified="2016-11-02" version="1">MPFSAVEFFHDSPWLKILEHRRAEIVIEPLYPRLGLLGGAANAGKMSKLAALAAKRRQKENQPPASEPRPGSEVKEEYLSDLKKLEITPSSRAKTATDNLQAREGQAPSTSEESSAEADRPKQAPEATLMVDQNLRGRPSKFASIMTNHGPESQSTPSTDFLAVKATAKSFSFAEPSPDDIVTKAQSAKAASSATPKTKDPAKPKTTLNNSVQALSIQDTPKIKSKHIDVLAEYKKTKRKNAANFVVIGKSTLMGRLLFELKAVDQRTMEKYRQEAERIGKGSFAFAWVLDQGTEERARGVTIDIATNKFETDKTSFTILDAPGHRDFVPNMIAGASQADFAVLVIDASTGNFESGLKGQTKEHALLVRSIGVQRIIVAVNKMDVADWSQERFTEIRQQMAAFLSSAGFQSKNITFVPCSGLEGGNILTKTTNAKAAWYDGPTLVEELDNSEPLTYALDKALRLTISDIFRHSIQNPLSVSGRLDAGAIQVGEEVVIMPSGEKAQIRSLLVDDEPQDWAVAGQNVIMNLTDIDPIHLKSGDVLCSTLSPIRNITECKAKILAFDHLTPMNVDVHKGRLHVPGRISQLVGILDKATGATTKKRPKIVQPGSVVRVMVQLDQAVPLEPPARIVLRANGETVGAGLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJC0</accession>
    <name>A0A1C1CJC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_03884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJC0"/>
    <dbReference type="STRING" id="86049.A0A1C1CJC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03884"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10282"/>
    <dbReference type="eggNOG" id="ENOG502QQ2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="68"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="781" mass="86897" checksum="491356BD7E7431A5" modified="2016-11-02" version="1">MPSERDPSGGGPSKAPVRFHGRKKKGNQLQKPWLYDLVLWALSILIDLFFREVHPRGAWKIPKTGPVILVAAPHANQFVDSLILMRLLKNEANRRISYLIAEKSTKRKFIGTLSAAIGAIPVGRAMDSVKPAKGKIFLPDQDNDPTLIRGVGTDFKNGDFEVGGLIVLPKVRGQTPSTEIAEIISSTEIRLKKPFKTAEALESLTGTGSPNGDPSEQQRGCSFKVAPYVDHSKVYDAVFDELEDGGCIGIFPEGGSHDRPDLLPLKAGVALMALGAEAKHPGCGVKIIPIGMNYFHAHKFRSRAVIEFGHPIEVDPEQVEKYKAGERRNAVGSLLETVFQGLVAVTQSCPDYDTLMLVQAARRLYNPLGKKLPLPLVVELNRRLVKGYTTYKDDPRVVELKKDVLEYNRQLRALGVRDHQVEWGNPAKRPWWLILGTLIYRLGELFLLGIGTLPGLAMFWPVFVTTKVISVRKSREALAASTVKLQGRDVIGTWKLLVAMAFAPALYIYYTVVVSVWLVYNRRDGYYTYRVPWWMVARTYVPDFIPIWLFAVLFFLVCIMVTFAALRIGEIGMDVAKSLPPLFVALNPRSSSRFVKLRQRRQALSERVTNVINELGPEVFPDFDAARIVADPYKEGVYQSKYKKMPEEPRIDSAEPTTPTSSAFEERSPESPSAKSMFGLLPSNEAFSNIGGFGFFASRPTTPKSRSRSSSAGGALTSASTFKMTSLDHDEVSKRIRGAMRERGRKREGEGAETETESSYDMADDGRMTPATEDEEPKKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJD9</accession>
    <name>A0A1C1CJD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Haloacid dehalogenase, type II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJD9"/>
    <dbReference type="STRING" id="86049.A0A1C1CJD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05094"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03254"/>
    <dbReference type="eggNOG" id="ENOG502S19E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29912" checksum="8911C169960AC82E" modified="2016-11-02" version="1">MSITNPPKALLTDVFGTVVDWRKTVTDFLTRRASEALNSPTSSIPSAVRTAAAGISWPDVAQLWRVSYYNFTRTYDPAEGQRDPSKFKTVDQHHVEALHKILVDHALEGLWTDTEVEKIALIWHFLDPWPDSSAGLAQLNARFETATLSNGNTALLRDLASHGSLPYKHILSAEDFGAYKPHPSVYLGAAEKVGCKPEECALIAAHLGDLKAARACGYQTIYIEREKEEGWSQEETKRAKDEGWVDMWVGLNEGVDRGGFLEVARRFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK37</accession>
    <name>A0A1C1CK37_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK37"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04757"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03097"/>
    <dbReference type="eggNOG" id="ENOG502RZIA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5328412at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="488" mass="52870" checksum="B8BD6B417EEF493C" modified="2016-11-02" version="1">MSKPKAFLKQSKSKKKVGQALDTADDYQAAGVDFEEAAGKWRAGDGAKSMRFSCRAIEVARILLEVATHPLLVPHLTRPLLEVLDQALSAHRYALQLDQDNPDTLFNAAQVLTAIAETYARDEEYAAQDALQLLEEALALQDRCLSIQELKFEEYIRQQNEAARSTGETPVEPAPAPSDDGNGDADEDGQQAANDLEDRWFSVVEPVTKDTLVDTVVAQLGTLTTLCSVLSSAESSAPSTSLAWIEEYSSKLIKAKLPQLLQDADAERLQEVALARANFVSELLKAGYAQNSIDPETYRRERDEAFRVAELGLERSFAALMANAHSLVSFNAALAEGPPSQAVSHAASGWSALSAAIANMATASKLSDPLPDDIADTHFFRGNCSLLQHQLGHPPVSYTAAVSNSKQLLKNAETFYRNASKLYQDGDQKAVAQLRAAVAQALQDSTDVIANAVHDCQAKGEEWIKNQLDDMVDDGLINPLPSVSQMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK59</accession>
    <name>A0A1C1CK59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_04879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK59"/>
    <dbReference type="STRING" id="86049.A0A1C1CK59"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04879"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03070"/>
    <dbReference type="eggNOG" id="KOG1318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="285"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="435" mass="47365" checksum="C753F72F7AFAA0B1" modified="2016-11-02" version="1">MSYSQPQSQSQSYPSYQRTLCDNNQSVSPGWNSFDGTCPPSSAAAAADFENYTQFPLDPGGYNDGNLLAAEEQIPQSPNYSQYLNFDSMDTGPAAAGAAGAAGSSPAVMSQALFGTSTIAAVNPEQYVDFAIKIEQPEPEQLQRQQQEANMSLPTYSPSMNPNLNLNQRDNRVLARTCGAVPACAHILESPDLEMEDLNLGEWYPPSTISPAERDTQLSRQLGADDPRRKPSADDGTGTGTGTGTMTRSSSSSAAAATTSKKPRKRGRKPLADDDDEAQAQAQVRAKQAHSIVERRYRDNLNGKIMQLHRTLSSIAAGGGNQNRTAGDYYLDGDETATQKPQDQRTGAGTRVRKSDVMTDAVNYVHQSEVQMRHMENEISRLTDRVRTLEKLVRCEDCVVLKEMVRRSLQAEGRAQAQVQAQAQAQVQGRSHRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKD4</accession>
    <name>A0A1C1CKD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Palmitoyltransferase pfa4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKD4"/>
    <dbReference type="STRING" id="86049.A0A1C1CKD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04869"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02945"/>
    <dbReference type="eggNOG" id="KOG1314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="352" mass="40282" checksum="7A429AEE5C48DEA3" modified="2016-11-02" version="1">MDTQQLAKFAVPGVVTLVAFLSYSSQYLFNRIEPGPLTFQQKITFNALVACIWISYARACTTDPGRIPLGWKPDEAEGTDSTNPRARAASRQRYCRPSPWQLVHLLILMIVNTLTVFLVSITFFRSIYGLGANVSTIESWEIERHEQLLRRARALGGYLDGPDGIRMKIVKQEFPYDIGIWNNISQGMGSANPIAWFWPLSATPRTSGLVFETNGFEDPGTSWPPPDPDRMPRVERPLELRDAFVHDHGSLSPDQEMVAFKQRQQADFERRSDFYGVQRRRPFHQRFAQDSLTPVEDDYARPEEDTSSGEEGWRNSDGNRLKDYGVDEDVEFYDEDNIPIAELLKRRREARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKE2</accession>
    <name>A0A1C1CKE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05270"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="89" mass="9685" checksum="D6A671CA77D8C54D" modified="2016-11-02" version="1">MNAGESRLGYCTGARRRQAGAKVKQTGGEEGAARDQKAAPWTSALAHHIMCSSGTGFRVSAMTIGEWRSGREFGGQLEKRSKRRYVLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKG3</accession>
    <name>A0A1C1CKG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKG3"/>
    <dbReference type="STRING" id="86049.A0A1C1CKG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04588"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02947"/>
    <dbReference type="eggNOG" id="ENOG502SB01">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="191"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="797" mass="88703" checksum="4AE812F92EA16AE5" modified="2016-11-02" version="1">MATDLGLNHGDHQHDSITSVTECILGLKEKIDEKALPGFSGLIDDWFNPDVPIDSEQFIRRFLHVFKQTEQDFTYEKIVGDYDDDVQEIFNDFVDGRIDATEAGRRYNQATADRVPNRRGDIRRGGLATAIAADPNILAEPINLFLAAPTSIPSRIRALFAKVFPKLKDPKRALYIPTYKNLEFINHGRTVENTPALTCVPNTAQDICDIVKFAKKQNMGVRVAGFRHSWSPVFGRSDKKHRQTNGDILISTLGLIDASVLPNFTSLPTDIFQPRAKDLNSIVVVDHNYVKGPLLRDGKKWCIKTGKVTMPMNIVEVEITMGGSNATICHGGGIRNPTISDLVRAIEYVDANGTLRKIDLSSPDILRAAAGCFGLIGVVTHLVLELDPMSCALMEPRKVPVIEAIPPPPDMPDSMIPAPLRPKHPLSPARKAEIQRDFETRATTTDYAEWFWFPYSSEVWVNTWHKTLDTSNAVDYPSDAKTILQVLGTFATQIAQDASILLKLTQALPETQTKLLTWLAMKNLDDIGPHGEKIKTWVPDALHFQRGVQNLRVRDLEVEFPLQPKLKLAPQLNGAVNANGHANGAVSSLPSTQSSDVDLLLVQRAWWDAILAAYAAIKTCPQRMPLEMRIMAGSNVTLAPQRGHKLGTCAIEILTLHNVADIWPAYAQGVLDKWTGYKDSEGAPVSVRPHWAKEWYGYTVKGRPWEEVLRDEESANGGFKNEIAEWRDLVGRLARRDGWTTLDARRRFGNEVLDWLFWGQEDGPARLSGSTIASADEAAKLKKQSPARKLLKSCFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKW0</accession>
    <name>A0A1C1CKW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05226"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02771"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650874" evidence="1">
        <location>
            <begin position="22"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="154" mass="16493" checksum="560B6F5C5DFE8353" modified="2016-11-02" version="1">MRTLHSVTAVLATLCTKTVLGRPGNHSLLARDQGWVIQVFGQLDCTDSGVILEGANPSLDPADISYVDWGIEWVGGIKILQVSTNGDSVYLDDERFIYLGLCGCSDSQITEFVHCGDQDTTACYTVGDTIGQIGIGETACDAVGLDSIYRKDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL12</accession>
    <name>A0A1C1CL12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_04535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL12"/>
    <dbReference type="STRING" id="86049.A0A1C1CL12"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04535"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02725"/>
    <dbReference type="eggNOG" id="KOG0615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000470">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="94"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="234"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="714"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1022"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="723"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1022"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116057" checksum="1E6CDEA93D28DA1A" modified="2016-11-02" version="1">MSQHATQPATQPARFRYNLSNVSDEDATDVICMLTPTSPSAFEAVKANLLHAPQHILQNHDLEDLEEEMLFGSNQSRDLALRMSSKVKCPKDGFRFGRNPNQSDVLLTGHENDTLLSKIHFKIYVNNQGSLMLQDLSTNGTIVDDVHLKARDRRGKPVLKPATTVLKNGSLIRVVCGPDKQEVKMMVRIPSRGDFEDAYEENLRKYLAARGDVAQFASMRESTYGNHWNGGSLYNFTGLLGRGAFATVYRIQTKKEGDLYAAKELDKRRFIKNGVLDLKFDSELNIMKNLKHPNIVNYIDCHNYQHWIYILMEFVPYGELAQQLRNRGAIPEVDVQQIAKQILHALDYLHRRNITHRDIKPDNILIASLNPLIVKLSDFGLSKCVTDQETFLKTFCGTLLYCAPEVYPDYGTYTQGSAPKRRRGLGEAASKPPPSPYDQSVDMWSFGAVIFHLLCGKPPVTGRGDDRGAQMLNNIMTKEVDFEPLRQEGISEAAVDFIARLLNRNPASRPKEAECLRHPWLRDVPDNCNYDDVEEPPVDVEHQLEDIGELSEDFVDDDMIDNLNQLNQPASSSPTRPAKRARTFVGAPPTASSITYPYLPGADQSLPPLPHETGPRAQRLFGEISASVLRSSGVFGGELNPLPSPTLVNNIRDGVEQISVNDFVERPSSRRAESEDNAGQPLQYPQVLEVPPAQTASAASLMGAEQQIGQLNMSSEGDISDAPTPETTNPVTPETRQMSPSDSLTPHVGPGLAEPAQPLEEPICTRQIDLNLVQDPVNFQAEIEARNASRANKLRTKAETFHVNMAGRTRSPSGELAATIDAKTGQVVQNAARAEQRFSRTIQAPADTDGTSSQTTQFIKPPRRYGKLTSMPGSFANVTINLEAKDTMWGRGDGCTIRYPNLSDARVPKYALKIYFWAPGMAPYVAGGGQWTDVPGIRTLIATSASRCIWVNGVALRKESASGDASYYGKLYSDDIVTVYDDADGFLKFKVEITFGGSARRRPASEKGFVIEEEHVHHQRMKERESMRLSMREDGGEVHNPPVAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL72</accession>
    <name>A0A1C1CL72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL72"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05203"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02682"/>
    <dbReference type="OrthoDB" id="10350862at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="173" mass="19718" checksum="8DD0928302F98A66" modified="2016-11-02" version="1">MGSVVAFSLEEVVIEASTTPPLSPPPFRRRAATVSNSQVGLINRLARTRASHVVCFFLAPGRYVVSMEVKVDGPSARYFIHLPQFSFMIKLRWRMTSMRPEIMRFRSSTEFFGEDDLRYLGGVAYTRPCSDRMFGVLRSKVYVVGRDGLRRCHRVEEAPREPCVERGREGILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLL5</accession>
    <name>A0A1C1CLL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05289"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="79" mass="9106" checksum="6E4F46C622514446" modified="2016-11-02" version="1">MTCRKAKWTQSPLLAQSGYPDPRWYEYGVLWTEYGVRGDRPPPMLGIDALPHTPSPRRPLRRKLLGAYCDHTGLPRSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLP9</accession>
    <name>A0A1C1CLP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Scytalone dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SCD1</name>
        <name evidence="8" type="ORF">CLCR_05115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the scytalone dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLP9"/>
    <dbReference type="STRING" id="86049.A0A1C1CLP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05115"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03339"/>
    <dbReference type="eggNOG" id="ENOG502SNND">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5281072at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030411">
        <property type="term" value="F:scytalone dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006582">
        <property type="term" value="P:melanin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004235">
        <property type="entry name" value="Scytalone_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049884">
        <property type="entry name" value="Scytalone_dh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02982">
        <property type="entry name" value="Scytalone_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024851">
        <property type="entry name" value="SCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like" evidence="7">
        <location>
            <begin position="8"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR024851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="188" mass="21918" checksum="5B07ED3681E8167E" modified="2016-11-02" version="1">MASKDKLISWEDYQGVLRAYWEWAESYDSKDWERLRKIVAPTVRIDYRSFLNKLWEAMPADAFIAMISDKKVLGDPRLMTQHFCGASTFEKVSDTEIIGYHQLRVPHQKYADETRSKILVKGHAHSSNQHWYKKIDGEWKFAGLNPTIRWGEYDFDKVFAEGREELGENEQEKIASDVAKQAEGIPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLT3</accession>
    <name>A0A1C1CLT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional cytochrome P450/NADPH--P450 reductase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Cytochrome P450</fullName>
                <ecNumber evidence="16">1.14.14.1</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NADPH--cytochrome P450 reductase</fullName>
                <ecNumber evidence="16">1.6.2.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CLCR_04529</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <cofactor evidence="16">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="16"/>
    <dbReference type="EC" id="1.6.2.4" evidence="16"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLT3"/>
    <dbReference type="STRING" id="86049.A0A1C1CLT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04529"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03373"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070330">
        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06206">
        <property type="entry name" value="bifunctional_CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11068">
        <property type="entry name" value="CYP120A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023206">
        <property type="entry name" value="Bifunctional_P450_P450_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF127">
        <property type="entry name" value="BIFUNCTIONAL CYTOCHROME P450_NADPH--P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000209">
        <property type="entry name" value="Bifunctional_P450_P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 16" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 16" id="KW-0288">FMN</keyword>
    <keyword evidence="4 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 16" id="KW-0521">NADP</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="18">
        <location>
            <begin position="502"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="673"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000209-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCT49478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1072" mass="119305" checksum="F18E67B7C85A998E" modified="2016-11-02" version="1">MTETIPGPRGLPLIGNLLDIWEDRSIPIRGLERLASMYGPIFQFTINGQRRIVCSSASLLEELIDEKRFVKIPPPTLAAIPGPKGLFVARNEDPDWAQGHRILMPAFAPLSVQEMFSDMKDIANQLILSWARKGPENRILATADFTKLTLDTIALCTMSYRFNSFYSDTMHPFVQAMDFIFQENTAKSSRPAFIQSLMFKANAQFEEARKVLQETGKSIIEGRRTNPTNRKDVLNTMIYGKDPKTGEVMRDELIVQQMITFLIAGHETTSGMLSFAIMQLLKHPDAYLKTQREINEVIGDRAIEASDMHKLKYLNAVLRETSRLNPTVPVLQKHINPAISHQIVTIDSGRYMIEPSDHVVCLVGKAQRDPKVWAESAEEFDPDRMLDENFDKITAEHPGCWKPFGNGKRACIGRPFAWQEAMLVLAMIFQNFDVKFDDPNYKPVVKQALTVKPDNLYIRVTPRKSMNATAMDNLIHSNGVKEHLAEPTLGRRSRPSDAAKPMTILYGSNTGTCQAFALRLASDAGARGFNAEVYDLDSATNSVPKDRPVIVITSSYEGQPPDNAARFVEWLSSCQPGSLSGTQYTVFGCGHRDWSQTFHRIPKLVDTLLEGAGATRIASVGLADASRGNIYGDFEEWVDSSLWATLTTGDSHGVNLATKVEISTNARSSNLRYDVSLATVKENRVLTAQGEPTKCHMEIELSPDAAYQCGDYLAILPLNSEKIVKQIMAHFSLPGDAVITIKATGPSTIPTNTPLSVFDVLRSYVELSQPATKKNINTLANLSDDASDKACLQSLANEDIQFEQEITQKRTSVFNLLTRYSSIKLPFGEFLGLLPPLQLRQYSISSSPLANPHTCTITYGVIEASALADPSQWFEGVTGTYLRGLQAGDSIQVSIRPTAKKMFRLPPNPEQVPLLMFAAGTGIAPFRGFLQERALQIQSNPDRKLAPALLFLGCRSPTKDRLYAQQLDGWVRNGVVDIRYAFSQEKEASEGCSYVPDRMIHDAIDLVEIWRKGARAYVCGTRKFAEGVRGAATKIAAMVRDDQHQRTEVEQEELQTRFREALETRVASDVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM15</accession>
    <name>A0A1C1CM15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Suppressor of SUA7 protein 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ssu72</name>
        <name evidence="14" type="ORF">CLCR_07414</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the cleavage and polyadenylation factor (CPF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM15"/>
    <dbReference type="STRING" id="86049.A0A1C1CM15"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07414"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09780"/>
    <dbReference type="eggNOG" id="KOG2424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSU72p Phosphatase and transcription/RNA-processing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT49519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="322" mass="35140" checksum="AA1CD718F884FC93" modified="2016-11-02" version="1">MSVDPRRARLQARTQTPQPAASISQAPPAPPVASAPVPAEPPVQPGPTTSPFLDGSVDSPPTAAAPLTASAPAPLEAPSSTNDVPFKLKFCTVCASNNNRSMEAHLRLSTSSHAYPVISFGTGSYVRLPGPSISQPQVYNFNTTSYTKMYEELNAQDARLYRNNGILNMLDRNRKIKWGPERFHDWVIGNPRMEALSRGDKGAMGAEGGVVDVIFTCEERCWDAVVDNLLDRGAPLNRPVHVFNIDIKDNHEEALVGGGAILELADSLNEAAIQERKISGTQGWENGTGAARMSFDEKVPEILARWQERWPNLPALWTLSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM88</accession>
    <name>A0A1C1CM88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">rpb1</name>
        <name evidence="19" type="ORF">CLCR_06533</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM88"/>
    <dbReference type="STRING" id="86049.A0A1C1CM88"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06533"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09822"/>
    <dbReference type="eggNOG" id="KOG0260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180034">
        <property type="term" value="P:co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15 19" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="18">
        <location>
            <begin position="239"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1545"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1549"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1588"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1694"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1726"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1738"/>
            <end position="1761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCT49562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1761" mass="193324" checksum="A6513EB2809E2237" modified="2016-11-02" version="1">MTTSLNFPHSTAPLRTVEEIQFGLFSAKETERLAVIDIEYPETMDEQRLRPREKGPNDPHLGTIDRNFKCSTCEENMNECPGHFGVIKLATPVFHYGFMNKVKKILETVCHNCGKIKALDNADFQQAIATRDPKRRFEAVWRLSKPRNICEADPPEDADQLSKGPAPPKHGGCGNAQPDIRRTGLHLYATWKPRKGDDDEDTTPDKKRIFPQDVLNTFRTLTDETLQMMGINLDYARPEWMILTALPVPPPPVRPSISVDGSGQGQRGEDDLTFKLGDIIRANQAVLRTEVDGTPDHIKVDLCDLLQYHIATYMDNEIAGLDKAQHKSGRPIKSIRARLKGKEGRLRQNLMGKRVDFSARTVITGDPNLSLDEVGVPRSIARTLTFPERVTQKNIDKLKRLVANGPNEHPGARYVIRDSGERIDLRHHKNASEMNLQHGWIVERHIQDGDVILFNRQPSLHKESMMGHRVRVMPYSTFRLNLSVTAPYNADFDGDEMNLHVPQSQESRAELANLCMVPLNIVSPQRNAPLMGIIQDTLCGIYKICRRDIFLTREQVMNIMLWVPDWDGVIPQPAIIKPTPRWTGKQMISMVLPPALNLERLDAKGEDPYVPTNDTGLIVLEGNLMFGVLSKKFVGTGAGGIIHTIYNEFGWETALSFFNGAQTVVNYWLLHNGFSIGIGDTVPDPDTVQKIQDAVDTKKAEVEDLQKKAEAEDLEPSPGMNVRQTFESKAMNALNQARDQAGAATEDSLKDLNNAITMARAGSKGSTINIAQMTAIVGQQAVEGKRIPFGFKYRSLPHFTKDDYSAPSRGFVENSYLRGLTPTEFFFHAMAGREGLIDTAVKTAETGYIQRRLVKALEEVTVKYDSTVRDSRGNIVQFIYGEDGLDGAHIENQKVDIITMSTKAFNDRYLVDIMSGDVSMWKGRLLQAREIQGDVELQEMFDLEFANLKASQQLLRNMGKGTEDSMQLPLNIGRIIDQAQKNFKIRRGDKTDLDPRYALTAVNQLLDRLVIVRGDDPISKEAQDNATLLLKAQLRSRLAYKRLVLEHGVNRLAFDNIIGAVESRFTAANAAPGEMVGVLAAQSIGEPATQMTLNTFHFTGVSAKNVTLGVPRLKEILNVSQNIRTPSMSVYQLPENTGDKDAAKLLRSQIQHTNLRSVAETCELWYDPDIQNTIIPEDVDMVDAYFILPEDGEADLSLHSKWMLRVILSRAKLLDKGLDITQVAGKIKSTYGKDLAVIYSDRNADEQVVRIRLVQNYGKDEEDDRKEDDEILRRFLNEMLDHLTFHGVPGVERAFIDQKSRSIIKPDGSVFMAKSDPECNEYVLETTGSAFAKVLAVEGVDATRTYTNRFTEVFEVLGIEATRAAILRELTQVLSFDGSYVNARHLGILCDVMTSRGYVMAVTRHGINKSDTGALMRSSFEQTVEILLEAAAAGELDDCKGVSENIILGQHAPVGTGTMEILLDQAMLATLPANSGYGLGGPIGIKTSQQLLEGAATPYDSGSPMQDNGYLGSPDYGASFSPIAAPGSETPGGFTDYQPGFGGAGGFSPYGSRSPGGYSPASPFGTTSPTSPGFSPTAGYSPTSPMFGATSPGFGPTSPSFSPASPAFTPTSPAYSPTSPGYQSPTSPSYSPTSPNYSPTSPAYGSPTSPSYSPTSPAFSPTSPTSPTSPVYSPTSPMYSPTSPMYGGGGNKQSPTSPSYSPTSPTYSPTSPSSPTSPSYSPTSPVYNASPRSPQARNQSPTSPQYSPNSPQYSPTSPKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMB7</accession>
    <name>A0A1C1CMB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fatty acid repression mutant protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FRM2</name>
        <name evidence="8" type="ORF">CLCR_07617</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMB7"/>
    <dbReference type="STRING" id="86049.A0A1C1CMB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07617"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09879"/>
    <dbReference type="eggNOG" id="ENOG502RYI9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2138173at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF1">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="205" mass="22728" checksum="9A5621857E706250" modified="2016-11-02" version="1">MSPNTADSLIAAVAERRSVYNLSGETTISKERLGEIVRKVLLATPSAFNTQSTRIIVLLGDEHQKLWDIVRAGVTPLVAAEQAQATEAKIAGFQRAYGTILFFEDPTPFGPLQAFKMYADKFPGWREQTSGMHQLLVWTALEAEGLGANVQHYNPLIDEKVQQTWSEKIPREWQLLSQMVIGKPVGEVPPAKEKKPVEGRFAIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMQ2</accession>
    <name>A0A1C1CMQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07603"/>
    <dbReference type="OrthoDB" id="4113557at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="214" mass="23413" checksum="159216848705070C" modified="2016-11-02" version="1">MSITRGSLQCIATRLVISPPPATLGESTAVLKRLQSFGHVASFTASPRLEMPQPHRAAQNEQLEMTVLFSSRETLERAQTASPFTVRVNHHLPDPRVEDPYNVRNLQSRKQPQPKTMVCRLDHQDAGLPSGQNILSAGFSPSVQTRLYQSLTDLSPPEGMAAALGVFHNDSSSIEPTPELVDRVPDLTEMYLSRPSDLSTRVSGIPASTESTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMZ3</accession>
    <name>A0A1C1CMZ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ubc11</name>
        <name evidence="10" type="ORF">CLCR_07600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMZ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CMZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07600"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08815"/>
    <dbReference type="OrthoDB" id="10253686at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23791">
        <property type="entry name" value="UBCc_UBE2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="35"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT49898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="200" mass="22417" checksum="3FE3595E55002565" modified="2016-11-02" version="1">MNFSLEDSQNAAPGLPTMAEQNKLNVATRKADTQSVTKRLQSELMALMMSPTPGISAFPDAAGNMLHWTATIVGPKDTPYADLNLKLSFEFPGNYPYSPPVVLFKTPIYHPNIDFSGRICLDILKDKWSAVYNVQTVLLSLQSLLGEPNKYGHFRSCRNEQMLIFNCSASPLNNEAAQLHQKDAEEYQRKVLARHQEIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN11</accession>
    <name>A0A1C1CN11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN11"/>
    <dbReference type="STRING" id="86049.A0A1C1CN11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11353"/>
    <dbReference type="OrthoDB" id="15108at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE 6.6KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="73" mass="8696" checksum="7419D5CAFF26E94E" modified="2016-11-02" version="1">MAGPTPLRHDPALEKMYQLNKERWRYFRWTPRTAFISFMYAIFVPTVVGYSFAKTDGKWDMRAKLRGDTISEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNU0</accession>
    <name>A0A1C1CNU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07461"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09060"/>
    <dbReference type="eggNOG" id="ENOG502TAPJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4152170at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="34350" checksum="C8D33823C2F56525" modified="2016-11-02" version="1">MTDGLTMLQELHHDILTHIVSFLDAPSAVCLALTCHQNYESILSICRRSQLEDICPRDVGKPLPKIIDAQSYNTLALDTAGESKPPNEIPDRWMIDNFQFAEIPDTVLHHNGYRPDERPMMAKHLAYIRHVEWHHKAEGDAQPSHQAQLSVVQGIYPRAQISFDTSLSRSYLRTTSDFSRRFEDVAREFILMLDLWNQQCIESMDFMTLRERLGDNWIKTKTISVLRLKQRKMRRERALRRFIQLASNFHAPAPRRAGKLRRIVRKVSREFGYHGHAYSGLIWIEERIRSILHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPZ3</accession>
    <name>A0A1C1CPZ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Centromere-binding factor 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">H/ACA snoRNP protein CBF5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Small nucleolar RNP protein CBF5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">cbf5</name>
        <name evidence="17" type="ORF">CLCR_07033</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. Catalyzes pseudouridylation at position 93 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPZ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CPZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07033"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05429"/>
    <dbReference type="eggNOG" id="KOG2529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="16">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="15">
        <location>
            <begin position="271"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="365"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT50584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="501" mass="55752" checksum="4C27B4D92769AFE1" modified="2016-11-02" version="1">MAKVEDADFSIKPENVTPNIPTSEWPLLLKNYDKLLVRTGHFTPIPVGCTPLKRDLKSYISSGVINLDKPSNPSSHEVVAWVKRILRVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKLPGGEAQFARALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNDRHLGVFWVSCEAGTYIRTLCVHLGLLLGVGAHMQELRRVRSGAMAEADGMVTLHDVLDAQWMHDNNRDESYLRKVISPLESLLTTYKRIVVKDSAVNAVCYGAKLMIPGLLRFEAGIEVHEEVVLMTTKGEAIALGIAQMSTVELSTCDHGVVAKVKRCIMERDLYPRRWGMGPVALEKKKMKSDGKLDKYGRPNENTPAKWNAEYTDYNAPTTEGTTSAPVAETTSKSDVLAAPALAPTGEDADTSMAMDEVPPATNGDATVKVKKEEKEKKRKSKHEGETPEERAERKKRKKEKREKKDKKKRESGVKEDSDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ76</accession>
    <name>A0A1C1CQ76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ76"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ76"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07350"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05353"/>
    <dbReference type="OrthoDB" id="10016252at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="359" mass="40131" checksum="B2BA974F13C8B9B4" modified="2016-11-02" version="1">MPSNTRRTASTFCDRGPSALLPEAAIGGQSEGFYFVAMRRMSCPLVCICTIRSETLLTGEVGGQGIASGFRDASGIAWRLALACRPNFDGSYNDLFHGWFLERKQQLDRSLASTVVNGNLTTARNPVKIFLRDWVLWLMQLVPPWRHRLELGPRADGMGRYRYTSGMAFLPDMAGGSCLPQVYCRSVHHSTKNEPAIVQFTDDVLLSGLRANALLRLLIAVDDLKQAERAWTELKELDLEKSSNGEVRGSTALFLIHDPTFEIQPEDSLSDLLPASIYRIATADEFAASDLCQNRPYPTGYDMYRIRKDMKGRKYILMRPDRFVYAACNTGTELLAACERIPTTLLGSCQKPERSKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQT6</accession>
    <name>A0A1C1CQT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQT6"/>
    <dbReference type="STRING" id="86049.A0A1C1CQT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09198"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09494"/>
    <dbReference type="eggNOG" id="ENOG502SA5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3597994at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="173" mass="18677" checksum="F8E694BF58E10CF0" modified="2016-11-02" version="1">MAPSRGRPAAQAAYLNEHENAALDQQSNSALVSARRNFNYLISPTNAERPSRLRTRALLRTVRYVGQFILWRLVRWAKYIAVGSIVAAIGATAIGGAISGVAWVVAPPSIGAGIVAAGIWGVGRFAARRLHAKWKKGGGDMGAEVRERVEDRGSDIRREGSYGMDLGPRAVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRF4</accession>
    <name>A0A1C1CRF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09365"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="77" mass="8538" checksum="748FC345EBA4E5ED" modified="2016-11-02" version="1">MASRKVARERESDMQMCQAGNVGVAAMQDRHSQSILRREQRNESMHTDGPQKPCNQIKTTKATRTIPAAPACVLEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRS5</accession>
    <name>A0A1C1CRS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08554"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06863"/>
    <dbReference type="eggNOG" id="ENOG502S3V7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5593235at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="462" mass="53326" checksum="FFBE416462CD02BE" modified="2016-11-02" version="1">MRSTTSAWCRTRQRDVETEEFQAQLQQELPQRNSYIGVKEKQPLLPMSSVTSFAPGRNNSRVRRSLAVALVGALCFVIFALHRLHELQFQRPFSFPTSESATGFSSDLRVWQFDKPDDVKVIGLVFFGRKSRVEILRCYLERNLVDHGGWLDEIHWVKNTDNSDDLKYLEEILASSPRYKTVELEGVGFVGYGQAWGKLERGSLYVKIDDDVVWFDDDTIPRIVSMKLAHPEYLLVAANMINSPLMGWVHYHMGALHPYLPELADYQPDIFHPRKPSRKPWTYWSYPEWTGPADYFFGITQEPPYDGHRWLRLPDDTAIHRTPASEIEYATWGTGLKSWAIAAQEHYSFLENLADDHLDVYKMGVRSVDPDGGKPWFTVDKRLSINFITVWADDVLDNVPMDTVDEEWLTVNLPKKLQRQVAVNTDALAVHFTFGTQGNVDTTDLLARYRDYALEERCARRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSN4</accession>
    <name>A0A1C1CSN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_08964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSN4"/>
    <dbReference type="STRING" id="86049.A0A1C1CSN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08964"/>
    <dbReference type="OrthoDB" id="5126878at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30942" checksum="7C12F6A505C6D018" modified="2016-11-02" version="1">MFRAQDMTPILAGKDSIFDQPAWLALTAPKLFNPEYPDAERVEEYLSRFVVRLPRLVRLTRTAKQNPMDEIACADAATLATHLYLDTLEDWIRRVTTMGLVRTVPTTEPSCVPLTARSCEFASARVFKRIVLYWRLRCLVSGCILTLLQVKAAHMPSFAAAAAVLLDKLGEGATASVQSHEERAAECIAMSVQWAMTSPSPFPVYKLLVVSPLMNAFGVWMRSERRPTNVADSQRARNLQVWAVEQITAIARTIHAPEMGVAQLEAMNMVLMGGPLPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSQ7</accession>
    <name>A0A1C1CSQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSQ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CSQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08071"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06568"/>
    <dbReference type="eggNOG" id="KOG4208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="245"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="351"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="676"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="763" mass="82455" checksum="C1D628215BB24BA6" modified="2016-11-02" version="1">MGSTKRKESSVATDETTKKGKKSKPVDKKNATKTEAGDGTTPAADPDTSSNMPSDVMPKSAALDKSTVVKSKRSRKRAADFMDGDEAADSDGGVKLPENVPAQISDEPAKKKAKKSKKTKKSEDGEPLTADGVNGVIEHTGEEELETATKHKPVSTSMQAEAERTVDHELENGFGGFASEADEDDDQVEADDNAAALLTGFDSDTEDKQEDEGLDLSKIPALPKSKKLQKKLDKAKANGGHEGPGTVYVGRIPHGFYEKEMRAYFSQFGEITRLRLSRNKKTGASKHFAFIEFAHDSVAKIAAEAMDNYLMFGHILKCKYAEPGSLHPDVWKGANKKFRKIPHEKLERERLAAPKTEEQWQKKVDKEQRKRDKKAEKMKAIGLEMPLSTLTSPSAALKERLADQGVPQPIEDGNTAPAGAIEPPADVPKDEVAIKEGKKSKKEKKSKKEAKDEAAPIPDPNPSVEASVVDADAKKEKKSKKEKKSDPQTVPDANPAPVSSVVNGESKKEKKSKKGKKNEGAAVPISDPSEKSAQATTKKAAEVKDAEAAPQPQAMEVDAPVSTTDATSHDAATDSNQTGLTKAEKKKLTKAEKKALNADRKALQAEKKALHKAQKSANKPTDVPEPADIGDADEQAEEGPTPLPDANAELSADFISLGQFDDKEGKAAQSPNGGRGRLKPLKVKKPKKERKNLVKARGPKSKLVATKPKPDPNAQSMIPGLPVMGKGKYDKATRMAYKEMKKKIVAERAARGLPPHRVRGEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTG9</accession>
    <name>A0A1C1CTG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ADIPOR-like receptor SP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_08872</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTG9"/>
    <dbReference type="STRING" id="86049.A0A1C1CTG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08872"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06324"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="321" mass="37302" checksum="C06F81E2B9085DB2" modified="2016-11-02" version="1">MSFILAYRRPKEKLVRPRAQSIPSLQENFIHQYRPKPYRLLKFEELPEWYQDNHFCRSGYRPVSNSWTTCLLSLGHLHNESLNIYTHLIPAVGLMFGQFLIYSGLSYFYPDASIADHAVFSVQVNAAIITMLLSCSYHTMICHSKDIENLMLRVDYVGILTLILGSFFSGVYVGFYCEPVLRRVYWTMIISLSLITATLVLHPKLQGLKYRPHRTWAFIFTALSGFAPIIHGIVLYGWDEMWVRSGMPYWFLEGLVYGIGAFFFITRLPESVWPGRFDIWLSSHQFFHVFVVLASLVHLYGVWAAFDWNYQHQRMCPAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTU7</accession>
    <name>A0A1C1CTU7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTU7"/>
    <dbReference type="STRING" id="86049.A0A1C1CTU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08570"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06235"/>
    <dbReference type="eggNOG" id="ENOG502QSAH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="50489" checksum="E62440CCDEA063D4" modified="2016-11-02" version="1">MAKTKTKNHTQQQKDILRSTSAALVKSPPKKSQKSIEDLLTEAAELLEQSQPELALPLAEEALQRLEADRRRQKPPSQEGDETDIEELLSLAAEGQPTLPTALILNAEIRVALGDVDPARRNFTRATQMDKDGALISAEPWLWLAQLCEEGGRESIRYFEQACEVLRNEIDVLEEAASGDGETGARKVLDEKKAKLADALCAMAEVYMTDLSWEADAETRCEALVTEAAAVCPEDMAAGVLQTLASVRISQERIDEARTALKRSLEIWHKETGPPGSSEDTAKDATQSDDGTDEDARKPDFATRVSLTRLLMEVELEPLALSVLDGLVREDDQSVECWYLGGWCHVLISQKAGITSEEKSKTQQTARTWLENCLRLYRVLSYDDERLRDHAVELVDGLKKALGAEGEMDEDEDDAWEDVDEQDGDQDDDGDVELEIEDEDVTGPGATKTGDGDVEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTY9</accession>
    <name>A0A1C1CTY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTY9"/>
    <dbReference type="STRING" id="86049.A0A1C1CTY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08563"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06158"/>
    <dbReference type="eggNOG" id="ENOG502SN3J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5295627at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049232">
        <property type="entry name" value="DUF6829"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20717">
        <property type="entry name" value="DUF6829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="460" mass="51726" checksum="744C0B1F712349B8" modified="2016-11-02" version="1">MQTLHEVIEDGSFWLLPDRAVLELIRSEFPQELERLKNATFVRSSDAPRPQGPSIAESLYGQDYPEINRTLVGVLALRWLHNDDYDRFIGTQGPPPIVLKRQSFAWLRSLFDKGLKSIEDTYTLIVSMVTNDLGKDPALAADYAKKVGVDISKVNHDMILYHAVEEGMVPALDRLTKQARDYLLLGIKLGSDFNFGQLAQAENAPASLSGLLDMRGHDRAFEMRFMEQILDLAGAAGHEDWTCARKMVEPIFQSYRNVYDVAHGIIYEQMPLREGYDIILRRKLALLHQAGYSRQFDITQPGDRALMRLFCLGNTSNAENADIFFTAFTERISPETRSQLTHGLNVDGSVEEPAVQPTYIPAMLTKAIGNTATGSQREKITAVAAMLRFLGRCFVVEPQTLQRLPRGVTVIERDVRKIIPVLESDEFKRDPDVLDKESIPESQVANMAPGLEVSGWEDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU08</accession>
    <name>A0A1C1CU08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_08590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU08"/>
    <dbReference type="STRING" id="86049.A0A1C1CU08"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08590"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06143"/>
    <dbReference type="eggNOG" id="ENOG502RYZC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="36"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="414" mass="46401" checksum="513AED6C86111C37" modified="2016-11-02" version="1">MIADSSVSLDTTLDPLPPVLRRGLVAVAFFGILSLVSSVALLTFLTYRLCVWYHRGQLRDGANQFLLLIYNLVLADIQQAMAFALTSVYLSQDKIEVGTTTCWANGWFVSTGDLASGVFIFAIALHTYFAVVRGRRVSNRVFYGAIASSWIFIYLMAVIGVGLDPKLYQRAGAWCWINKKFDKERLWLHYFWIFICMFGTVVTYILIFLAITAKSRIRPQVNFPNHDGSDPAAMKRAAKYMIIYPVVYVVCTLPLAGGRMASMTGMTVPYWWFCLAGAAITSCGWLDVLLYAVTRHVLIFRRGPPPPQDLGLDTFGWKDVGDGVWGMRTTVTGPLGDPNTRRRDKRDFLGRRPPRPISRQSDEAHFAGQPEGIITAKTTIEVRSGPIINYADSDISAIEMEDKSDRTHSHSRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUP8</accession>
    <name>A0A1C1CUP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_09050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09050"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05935"/>
    <dbReference type="OrthoDB" id="4130448at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651071" description="EF-hand domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="221" mass="24387" checksum="406EA6E0319A1CC3" modified="2016-11-02" version="1">MSLLVLLAISLWILQLQLPMVNAKCCWGDILYNECGDGSFGTPCCGYKKCNAFCCACHGTQVIDEWVSNCGAEFTSYVSALPGTTWTCRDSHVSTILPCVKHRTPSRPTAMIDSSDDRPIATITHMPRPTSPATFAHPLYSPEEFADLEDTFDRVCAGRRHKGRRAFSLDQYFGFFNVTDTQKGGPYANSVEGKFRAHDLDGDGMLTFDEIQLVCDADGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVT2</accession>
    <name>A0A1C1CVT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">2-epi-5-epi-valiolone synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acbC</name>
        <name evidence="9" type="ORF">CLCR_09973</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Noorani M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVT2"/>
    <dbReference type="STRING" id="86049.A0A1C1CVT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09973"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03988"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08199">
        <property type="entry name" value="EEVS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000015">
        <property type="entry name" value="3-dehydroquinate synthase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000018">
        <property type="entry name" value="Related to 2-epi-5-epi-valiolone synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050071">
        <property type="entry name" value="Dehydroquinate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035872">
        <property type="entry name" value="EEVS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622:SF3">
        <property type="entry name" value="2-EPI-5-EPI-VALIOLONE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="7">
        <location>
            <begin position="86"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="8">
        <location>
            <begin position="195"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT52599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="503" mass="55385" checksum="F77DCBA149EE7607" modified="2016-11-02" version="1">MSDLKASVAETAAGFHVEGYEKIEYDFTFIDGVFDTSRSELANCYQRWGRCLAVMDYNIFNVYGEQMQKYFDHYKIDLDVHKTMIGEKAKSIDTFLSIVDSMNKFGIFRKEPVLVIGGGLVTDVAGFACAAYRRNTNYIRIPTTVIGLIDASVSIKVAVNYGNYKNRLGAYHAPMHTFLDFTFLRTLPEAQIRNGFAELIKISTCAHLPTFELLDKFCEQLIGTGFGRADGAPKEVRDAADAINRAGIHEMLKLETPNLHEIGLDRVIAYGHTWSPLHELVPEVPLRHGHAISIDMAYSATLANMRGILPDEDHKRLLNLFSRAGLSMDHHQFDEEILDKATKAILRTRDGKLRAAVPSPLGKCVFLNDVSMDEMFAALKHHKSIMKNYPRNGEGLEAFVDASDTGYTVNNKPIEAETNGISNGLKKLNVLNDDTYKNGPQTNGHSDTDGKNTSGVATAVKHASGPEGVNGLGNGTNNDTTNDLVDGVAHGINGQRNGIKVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVU8</accession>
    <name>A0A1C1CVU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_09462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVU8"/>
    <dbReference type="STRING" id="86049.A0A1C1CVU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09462"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03989"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="575"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1022"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1205"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1022"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1074"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1229"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1240"/>
            <end position="1253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT52600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1291" mass="141178" checksum="5B853DE9495E0D51" modified="2016-11-02" version="1">METTYFTCTLGQAVDHQSDKSYSTINELIEHKVRSVPGIPVVGFYEVEVGEKASQHWKPHVLTFADVHRGTVVGADRLSKVLTAEKGQTVALLCPSSADFLFTWLALIWLGHPALLIAPQCSPSAVTQLCKACGVKDLLYDEGYRDLATEASRLESGSLDALLLPSASENIFEVIKGTSVNVSVPPATVQETDIAYLHHTSGTSTGVPKPIPQSHRAAVGVLPTLNGRSKACFTTTPLYHGGVADLFRAWSSDALIWLFPGKELPITAANVCKCLDVAATSANDSSVGTSEVRYFSSVPYVLQMIAEDKHGLKHLQRMDIVGVGGAALPAEVGDKLVANDVNLISRFGSAECGFLVSSHREYAKDKEWQYLRCSPGGNHLLFEPQEDGLSELVIQHGWPHMAKRNRDDGSYATADLFARHPSIPHAWRYHSRADSQLTLITGKKFDPAPLEDSIRASASSVLDDVLIFGNGKPYPGALLFPSRDAVSTGMNMSDEDLIDKVASMVEKLNPNSQSHARIPRNMLIAMPRLDNGLEKSSKGTILRRKAEDRFSEAINAAYESLLPEGASCSTDVPDVDVSTTIRDIVMKVAGENRSCEDEAAELTDETDLFSYGIDSVASIRIRHALLALVPKPATLPLTIVQDAGTVSRLTDLVLRLRSGGEASISTEERDEREQISTMLDLAREYSSFNDPHPRAVSSTSPFRGVSRQDPIGTRVLLTGATGSLGAHILWYLVSNACISQIHILVRGATPLARRERILKALSSRRLSIPEDFDAKVTIHNCKLSDPRLGLANEEYTALAASVDVIVHLAWSVNFLQPLRSFAPTHIAGLRNLINFALSSPPSPSSSNQAHIPPRLIFCSSVAAVSNYTPRPPGKKLVPERVLTDNDDDADDATTTVAGPTGYARSKWVAERMCWHAHATTRLRGRISVARVGQLSGARDSGVWSATEAYPLMLASAAATGVLPDLDGARHAQGVREGEVLAWLPVDIAARAFVDDILAGDEVDMAAGGFVDDIPVGDQVDHAVQDQKQDQKQDQKQDQKQDQKQHQKQDQKQHQKQHQKQDQKQEQDRHPETMNKPNDSTTARNHAETGGLLETSESPETTDHTRTHTFGTSSKPPSSQMPVHHVLNPCRAISWNHLLTWLSRHETFHIVSVDAWLSRLEALNDSPEEWKRNHPSLKILPFWKGAYASSDTAAAAASSFARDVQNEADNNNNNDNNKPPCDRREGVAGTTDSLVPPTQETATTATTTTTTTTTTGYEMEGTYARMPSLRDWERVVTEEYVLKLWTWVKESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWB9</accession>
    <name>A0A1C1CWB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10519"/>
    <dbReference type="OrthoDB" id="4159618at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="35097" checksum="E649530C31219210" modified="2016-11-02" version="1">MVQTRNGYCGKRVGSPRKLRSGYVGVRKSGNAPKTHRVHKTRRLPPAVLQTTVTAADPGVVEVLSRVPNDDLLATASSAACEQECTGQAASESGEQKQRDSDLHEHELSTTITTLHDPSTDAEVDGALREDQEQQNPDDATDVGEPSLTDENVGIPRDGLWEHHEAYDRRFCYDHEQTEYLLGTANRWMSADEVDDDKGVLETMLLKPGDESPTFNPHSRKCQADCRGSLLSQVHAVLNKRKRGDGVEYLVVWKACWTPEDHVDDPSWIPASLEANRDLRRHRWSTRNASSFEQRREKSEKMMWYKDVDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWM4</accession>
    <name>A0A1C1CWM4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_11415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWM4"/>
    <dbReference type="STRING" id="86049.A0A1C1CWM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11415"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04180"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF269">
        <property type="entry name" value="HYPOTHETICAL D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651093" evidence="4">
        <location>
            <begin position="17"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT52836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="216" mass="23367" checksum="8304CE7FA34816DB" modified="2016-11-02" version="1">MAMFLVLAVLRDTTRAEKSLRSGSWKHGLVPSRDPTGLTLGIVGMGAIGKYTARKAAAFNMHVIYHNRHQLPRDVEKEYNATYSPTLPALLSASDVVSISCPLTADTTKLISRAEFAAMKPGAYLVNAARGSIVDEDALIDALESGRVARAGLDVFPNEPHVNPYFLASDKVVVQPHMGGLTDVAFGKSERECFENVRCLFRTGRPVAPVNEVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWU0</accession>
    <name>A0A1C1CWU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10832"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04348"/>
    <dbReference type="OrthoDB" id="5423884at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="180" mass="19690" checksum="F7FB2B742F03920A" modified="2016-11-02" version="1">MDSFQAFDFAASGAAALAKRQRGILAIPTTYLGLNSGPSPGILTAIVVGAVGGFLLIVYVIYAIATFGSGVFSRKTTVVEEDVVHHRASSSGRRRRSRGYQEEVFVERRTSRRPASSRIRETSRGDVEGEHDAPRVEHLMGGFYLARRHDFLENEDGAYRIVGCTHDSLISLTLWDDTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWZ1</accession>
    <name>A0A1C1CWZ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin filament organization App1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWZ1"/>
    <dbReference type="STRING" id="86049.A0A1C1CWZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10209"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04302"/>
    <dbReference type="eggNOG" id="ENOG502RYXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF1">
        <property type="entry name" value="FILAMENT ORGANIZATION PROTEIN APP1-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="229"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="440" mass="49232" checksum="F48AFAF933422085" modified="2016-11-02" version="1">MPMRGFRTKHKSSAMETVEQKPNASPAEAQARQEANFADIESRLPKRYRRTEMGLIDKGTALLGSKNPFGKEATAKDNIVWLLDNTAYRPVKPGRDDAQPWEAEFVACFFHKGRKDISKHVSAIADIIGLDGKTGSNEEARKRIEERLRPFIMAIAPARTVDISIPCPTPNGTPHKRLLGPSNANGISSQSLLTGGADDADRKTVICTSEGNVFPDLKGDTRFAGPEGWGVISDIDDTIKVTMTTAPTGILQSTFADIPVTTSGMEEFYKVLDESLKKPAWFYLSASPYNLYPFLREFLDKHYPPGTMILRDASWMNFAGLLQSLTLGVESYKTDRIEKIHTWLPRRHFICIGDSTQSDPEAYADIYAKYPDWIKAIYIRKVTDAPHMENKNKPQRFRDAFKDIPDNVWRVFVDPKELADHVKHVAGVAHAGMLGNMLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXB1</accession>
    <name>A0A1C1CXB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_10477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXB1"/>
    <dbReference type="STRING" id="86049.A0A1C1CXB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10477"/>
    <dbReference type="OrthoDB" id="4160637at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651171" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="26"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="34997" checksum="2B8AF9909C5EAB9D" modified="2016-11-02" version="1">MIERDARTSIALQCALYLFLGSVFAQDNRPVDPNNHFISPPLPGPQANVDPSVFWSNQNWTVGVQQSIDWNWITNHTNLMITLQQEGNPDSVQARTILDCPEASTTSLIYWDGDVSPIDLNNGSIAYLAAWDCDQPDATPLFFSHYINLTEPAVVTTSSSSTPTTSSPSSTRTNAAPVTSSTPFGSPSTPTPTPTPTPSTDDTNQGTHRSSSDSAALGGGIGGGIGGALVLIALVGLLLFWRRGNKNKAKRNAGPSHEMSSSTKHDLLSPDVMYPSNPYQYAQHGHGHVYGHGYGPTEMPGGPTTPRHQQTKLASSVELESTSHSGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY36</accession>
    <name>A0A1C1CY36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY36"/>
    <dbReference type="STRING" id="86049.A0A1C1CY36"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10161"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00378"/>
    <dbReference type="eggNOG" id="ENOG502SJFI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3937708at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651146" evidence="1">
        <location>
            <begin position="21"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="394" mass="41877" checksum="B14F0D2CF102236F" modified="2016-11-02" version="1">MHSSSAFVFALLALSGRSAADCLSYGYDFVDGGGPYCINTTSTSYFTFGTEFFGCQPSDVQDAVTPILIDPNGDEYFCSDIGVQPDGQDMVSICNVPGNELTKNNMFSGTWTAIMEGLTFAYMRSFAIIAAPPVTVTSTPTATFTVTTTPSTTITSTITNVFSTTAPASTVTVPTSTSTRTITTTPAQTTVYWTSTSTRTRTTRVFSKTVSTTTVTTSCQTQTPSKDPICTIRPTKATLAAAASTISMVPRQWTRQFQRPGIGRSGWSGWGGHRLARHRRDDTGAPVDTGPDMCTTTVVDTAKAVSSYTTVPAPTSTEIDTENATTTTTIMPPPVTAYSGKAKTTVTITAPTPTRTRTARTYETVWTTSTVWATITSTVKTPPSGWVCATTAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY58</accession>
    <name>A0A1C1CY58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mrh4</name>
        <name evidence="11" type="ORF">CLCR_09942</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY58"/>
    <dbReference type="STRING" id="86049.A0A1C1CY58"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09942"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00425"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="139"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="403"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="175"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT53459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="586" mass="65415" checksum="F2BC820D84E2FB30" modified="2016-11-02" version="1">MAIKSKIRERTTVVRSPSKPTVRTISSGEEDSGSLQSPAPRKEKKKDKDERPLFHALKMQQTLTPLSYGQRNKLKLEMEKITSFEDLGLMPSVVDAIYTQVLPHLTEYTPTAVQKLAIPALLSKKGEYQKQNKVDAEGKAVPNKYKTFLLAAETGSGKTLAYLLPVINSVKQQEELDHNEQLEREAQETKDREERDRNTVFDSDPLEDDSPPPNSSMGRPRALILLPSSELISQVTKTVKSMSHTIKYRSAGISSSNTPTVIRNRLFNPAGMDILVSSPHLIASIAKKEPNILSRIQYLVMDEADSLFDRSFAETTCEIIDRAAPSLKQLILCSATIPNSLDKFIDKRFPDCKRIVTPKLHTIPRRVQLGAVDIDRAPYRGDRDLACADVIWTLGKAVHEDLNPKNTVKHILVFVNERERAEQVAQYLVTKGIEAVALTRDTTEQRQAEILSSFTSVEKVDGSSKPAGATTTNPAKKLFRDFVPFDRATTPTPSGSGKTEARPTRHLPDVKVLVTTDLGSRGVDTLAVRHVVLYDVPHTTIDFVHRLGRMGRMNRRGRGIVLMGGKDRKDIIREVRDAMFRGQALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYG2</accession>
    <name>A0A1C1CYG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">smd1</name>
        <name evidence="11" type="ORF">CLCR_10934</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYG2"/>
    <dbReference type="STRING" id="86049.A0A1C1CYG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10934"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00482"/>
    <dbReference type="eggNOG" id="KOG3428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000008">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT53516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="129" mass="14081" checksum="5188C0A57BCC46A4" modified="2016-11-02" version="1">MKLVRFLMKCANESVTIELKNGTIISGTITSVSPQMNTALRAVKMTTRNRTNPLAPSETISLDTINIRGSTIRYYILPDSLPLDTLLIDDQPKPKNKARKEGDSRGRGRGGPRGRGRGGGRGRGRGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYR4</accession>
    <name>A0A1C1CYR4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">40S ribosomal protein S9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RPS9</name>
        <name evidence="11" type="ORF">CLCR_10645</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYR4"/>
    <dbReference type="STRING" id="86049.A0A1C1CYR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10645"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00628"/>
    <dbReference type="eggNOG" id="KOG3301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="105"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT53684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="193" mass="22260" checksum="1634D8827C2A4210" modified="2016-11-02" version="1">MAPRSYSKTYKVPRRPFESARLDSELKIVGEYGLRNKREVWRVQLTLSKIRRAARQLLTLDEKDPKRLFEGNALIRRLVRVGVLDESRMKLDYVLALKVEDFLERRLQTCVYKLGLAKSIHHARVLIKQRHIRVGKQIVNVPSFVVRLDSQKHIDFALTSPFGGGRPGRVRRKKAKAAEKGDGDDEEAGEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYW7</accession>
    <name>A0A1C1CYW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RAD52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RHM52</name>
        <name evidence="7" type="ORF">CLCR_10011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYW7"/>
    <dbReference type="STRING" id="86049.A0A1C1CYW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10011"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00612"/>
    <dbReference type="eggNOG" id="KOG4141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00077224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT53666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="538" mass="57203" checksum="3F07969253503E2D" modified="2016-11-02" version="1">MPAVGDQHKPNGSTTSNPFEDQPLRITEYTAQEIATLQSRLDKQLGPEYISSRAGPGGSKVHYLAAEKAISLANEVFGFNGWSSSIQNIQIDFVDENAQTGKVSLGLSVIVRVTLKDGTHHEDIGYGQIDNCKGKAAAFEKAKKEGTTDALKRALRNFGNVLGNCVYDKAYLQKVTKLKVGATKWDESMLHRHADFAPKKEADEVKRILPAAALEGASEPARPNPTVLAQEDPTEFEDSFELADFEEMDFCEDNMGHPDEVALPAAKVDPTRKSANSAPERSFPPPRADLTTPSKQQLTGPPGPRPEASRAPQISAPSNVIPQPLPGQRAQAPSGPATRPPAENVPRLSSPPQTGQVMGFYSAKAADSLDGNNSVIGGGPAAAPRFNPHADSPSIRKTSGVNHSKSVPLKRDLSVDTTPIRRDLVNPQAEQLRRVGAPGTSGQFAGTRGPSTSAYRPPTRRGPLESNATHGSNLVEVGAGDRGLQAAKRTPLGDVSNVQHHVTAVTTDGADAKRQRVAEALPHGEAGTTNNQPSSNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZC4</accession>
    <name>A0A1C1CZC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">QDE-2-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZC4"/>
    <dbReference type="STRING" id="86049.A0A1C1CZC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09623"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00708"/>
    <dbReference type="eggNOG" id="ENOG502QTQR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="392"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="569"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="792" mass="88528" checksum="F108D27BDD77C2F4" modified="2016-11-02" version="1">MATTNPQTRLDRLFANSPLPPAPTPGKPHFSEKELAEKKAKEEPPFRIGSTAEYPRQIRPTQKEGVQQARDILTSSDEDDYICAFKKKPEMKVPSKEVKSKPRKVPEPGAFGYPKGAVTEPKGPIEYLARGKSSKRNFTDSVGEPDSDDDHLPTADVHGNPAVGHFCQFSLAAKFPYKYMNDTNDRVSRHFFASNKFYSRSWDLKPIILVPYAQIRQLVTEIGQTFKIPVSVPRFPFTLTFFDDGTPQPIFLGKSNSRDDANDLQNNVPAAPMGHAECPKDASVTVKQAFEDFKDMCQSAIAAKGKNKSGVGKNKREDDRLLSIKDWYVQLRRAQRYLGLRRKTGQIQHPDPAMSWEEQEKFRHEQLKKAHFVLKPLNVNEPAPLPFEKEPVIIAVDVESYERAHNLITEIGISTLDTRDLVNLPPGPNGKNWLNQIRSRHFRISGREHLVNKDFCAGHPDAFQFGKSEWVDLKEAVAVVDSCFEWPFSVQFKHVSLDDQWAVEPAKLAKENNTQRRVSNDFGGVYIGPTNAEQDAASRAAIANVLNGIGNKEATTQAVGPTGANKTDSESLQQGPQERNIVLLGHDIRADVEYLRDLGSKIFAPSRATYPIPAMDMMANGEGKSKVLASIIDSMDTAPLYRVLKEETQNRSLSSIMSDLGLPCYFPHNGGNDARYTLEAWVAMLIKARIESDKDQHEKDQDAEKKLETVRENDAWNHGSEWHVTPLPDPGGPATPDDKTHQKDLDSFEAAIMASSPEVSPQYAKDKAVVATIEKLKLDPSVDHEEPAGHFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZS0</accession>
    <name>A0A1C1CZS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glyoxylate pathway regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GPR1</name>
        <name evidence="8" type="ORF">CLCR_10652</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZS0"/>
    <dbReference type="STRING" id="86049.A0A1C1CZS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10652"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00790"/>
    <dbReference type="eggNOG" id="ENOG502S2WG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="247" mass="26710" checksum="6395A0C774607E08" modified="2016-11-02" version="1">MSSYDAADQLEKSAATEGQAQRIERVHTRGGHEDDRTQPSLPVVHRSFANPAPLGLLSFATGIFLISAYGVHVRNIYTPNVLVAMIIFFGGICQYISGIMEFISGNTFGATVFSSYGAFNISYAMIYLPGSGILAAYTDKATGELSPEFSQALAMFVWAWFILTVIYTGAACRASWVLFLDLAFLDLDLLLLACGYMYNNQSLLVAGNSVGFVVAVLSYWAGIAGLYGGGVTPFNVPTFPMPWAEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0L4</accession>
    <name>A0A1C1D0L4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0L4"/>
    <dbReference type="STRING" id="86049.A0A1C1D0L4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00921"/>
    <dbReference type="OrthoDB" id="4509490at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="30144" checksum="2EBFDACCBC6B6CF0" modified="2016-11-02" version="1">MVVPKSLHPEFEPVTESGDGRMLANVTPTGSCFFPHIDLGLDGLVQCLGPGAKLIAAWPNTEENILTLLRTERSTTAFIRCIRSLHGGMLYLMRGGSTSLFLSAGTIHATITLQGGLLVGINTTSLGSLVSAMRALGYELCRASSNGLPINEILGISQRLICAPELQHEPGKQRSTLAQWPDLHAKIIDAVKRRTEKASSFQDWAVESQEMYSTLQALSSSLSRYTREEGSLAGICCGVANTAEHFATCHLSGMESIHGGAKARGTGQGKRRKGAVAPVPSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0R3</accession>
    <name>A0A1C1D0R3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0R3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00348"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10199"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651182" evidence="1">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="92" mass="9815" checksum="B178890508ED1A8B" modified="2016-11-02" version="1">MRLLPRLLVSVVFVLLPLVPEEQLSPTALVSIGAGMLVCVVAWELVGGLEKCAALFESWNLTADDSSDEDVVALRRDVQEDGASPGPDVEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0W5</accession>
    <name>A0A1C1D0W5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0W5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00968"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01641"/>
    <dbReference type="OrthoDB" id="2937326at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF1">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="16"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="177" mass="19368" checksum="4DF84FD72D359769" modified="2016-11-02" version="1">MTEMTEMTEMTSPSPIHPFYRLWFTRLDPIMTAGSIYVTFFHPEILLASLNPTYHSPPTPETVALLDLSGALFCVCLLLQLGLLGARPADVLVWHYYAVPVGLVDVIICAAILRGLSAQDRLAVRAWRLEEWMNLGLTAACAIVRAAFVLRIGVGVGVGPANADGDGDDEKARRKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D104</accession>
    <name>A0A1C1D104_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D104"/>
    <dbReference type="STRING" id="86049.A0A1C1D104"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00993"/>
    <dbReference type="OrthoDB" id="4362870at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="104" mass="11186" checksum="A6A587528A625931" modified="2016-11-02" version="1">MTGFGFCTVFQAALNYEYLVDTFSGYAASAVAANTLPAVVLCRSVSIFPLPFSFFLIPPLAIAPLYNGVGIPWDTSLFWILLHRNGACAVDVFTCSARADPKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D110</accession>
    <name>A0A1C1D110_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Respiratory supercomplex factor 1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RCF1</name>
        <name evidence="12" type="ORF">CLCR_00949</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with the respiratory chain complex III/complex IV supercomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RCF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D110"/>
    <dbReference type="STRING" id="86049.A0A1C1D110"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00949"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01643"/>
    <dbReference type="eggNOG" id="KOG4431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="11">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT54368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="224" mass="25468" checksum="EE3E20DB4CC7BC3E" modified="2016-11-02" version="1">MSNEAPPPSEPSPLSSSAIPSSFDSTPEFYEEKRFQKLWRKLRQEPLIPLGCAATCYALYMATKSIRAGDHHQTNRMFRARIYAQGFTLLALVAGSIFYKDERLKRKAFEAKLEEKKVAEKREKWLAELEARDKEDREWRDRIEKASVAARDAAEGVKEKAGRMIDGGKVEELVPPPGDLQSQEEGKKKAGWLFGNKSVLEEVGEEGWGPGKWAQRARDAWRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D190</accession>
    <name>A0A1C1D190_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative UBX domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D190"/>
    <dbReference type="STRING" id="86049.A0A1C1D190"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00842"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01732"/>
    <dbReference type="eggNOG" id="KOG2699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16105">
        <property type="entry name" value="Ubl_ASPSCR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17075">
        <property type="entry name" value="UBX1_UBXN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021569">
        <property type="entry name" value="TUG-UBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059238">
        <property type="entry name" value="UBX1_UBXN9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11470">
        <property type="entry name" value="TUG-UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="340"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="502" mass="54702" checksum="7EBEEEB8C5A02382" modified="2016-11-02" version="1">MASHVVVIDATARRTQIKTTPGKHLSEVLEEACAKLGLNAAHYGLKHNNKQVDLSKPLRLSGLSSGAKLELVQLSKSAGVVSIALQLPESEARGVPNARLTDKFPSSTTLWQLLRKFEAGVAGSTDPRNFTARGVPSTSQGNSGAGRLYYEQPVIQIMNRELASFTDLQKSLAQLGFNTGSALLRLSFRATQTPLEEAMVQIQEYFNSIEGEGPAAPPSQPQTNAPATEPQPAAATTQPEWTEDCPPQPASQTQPEEPGASSSQSQTTTSASGRPISVFRPPTASTPSAALRSHNEADYTPTIEHAQVHQKLLQQNSKNVRLKTEAELAAQAEEEAAKWAAVKDVEVKIRFPDQSTIVTPFSQSDTAADLYSFVRECLEDRWRSEVFLLRNPGIRGKNEFIPDDSGKRIIRDLQLKGRVLLTFAWDDQKASSQARSTKSVLKEDLRKHAQELQVQDVTMVDVEDNKDAGVKIKVGKMDTGGSEDGGQSKSKMPKWLKGLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1N4</accession>
    <name>A0A1C1D1N4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Abhydrolase domain-containing protein IMO32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">IMO32</name>
        <name evidence="5" type="ORF">CLCR_02996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1N4"/>
    <dbReference type="STRING" id="86049.A0A1C1D1N4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02996"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04889"/>
    <dbReference type="eggNOG" id="KOG2382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000039">
        <property type="entry name" value="Esterase ybfF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="66"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT54793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="346" mass="38787" checksum="354DC7D98081E978" modified="2016-11-02" version="1">MRGPRLLHRVAVELPSPRLIPELSRRQLSSSRTLLRHGKPADDDVVELAFSRHDPPEKTSMKGPGPIIIMHGLFGSQRNNRTMSKALAKDLSRPVYNVDLRNHGASPHSPTHTYQAMARDVEHFLARHQVRTPTLIGHSMGAKVAMTLALRQPTHYSALVPVDNAPVDAALAGDFAKYVQAMREIEEHRPPLKSQKDADRVLAKYEPDLAIRQFLLTNLVKANDTHTAAHEHHRPHGTSSPPGSQEPQPQPQLRFRIPVATLAKNLANMADFPFKDPHANQYKGPTLVVRGTKSHYVADETLPVIGAFFPRFELLDVDCGHWVMSERFDEFRSGVAEFMTRVVDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D256</accession>
    <name>A0A1C1D256_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D256"/>
    <dbReference type="STRING" id="86049.A0A1C1D256"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02837"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04896"/>
    <dbReference type="eggNOG" id="ENOG502S9CJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="634" mass="72532" checksum="A2A9125A28E46BF4" modified="2016-11-02" version="1">MAIAPGGENLADRERNPPPKTIPLEFPNYVPPRCESPLSQNHIKTVCRSLASIRRLADIQDSHLAHLNIQLDQDVAPSELVPDQQFEARPLLYDADLTAMLAELEVDNEDAYREILRMPPLEGRKKPRLAYSRNFFASLEDMSRYWDDSKDNYYEVESSNAEDAGKDLENAGDKSMETVKSNEVDMTGLSRNGQNIQRSNEQIVNSSHASAELNPPTTELPARPKMKQVYKGNRLGNGEQMTAGTRVAALRNLLKMAVHKFNCRDYDVSPREKLRIQNINVPAASYNFCVAKLPADPKLLRSRMVEGPLMAVHCRNEVRFKSREGLLGPTSDFVGEKFDLFREIGGMLMLAKQRAREGQTLSKEPREDQWWAIKSRWGGGEMKWGQLASEVFEDDDPSWSVEERRLQLEKREKEEEERRKAEAAAAADLNNLKPEDLISGPLTPGSERPKKKKKSGAEGGPTKDRSEYKDGRRLMYVPPLRRKWYQEWLKIRPNGPCWDEKIIYRTVGKVGEGEANVGWDDVYMLSGANHHACILRMSVHDNYLEWLETGKPGSANRDGTLGKSSSRQDHVLYVSRSAWYDLFEVEQRKELLVAIWRILSWMNRKEVPKEEIEKMEELKQQQAEQTHGDHEMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2A0</accession>
    <name>A0A1C1D2A0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2A0"/>
    <dbReference type="STRING" id="86049.A0A1C1D2A0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02938"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05103"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT55013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="469" mass="47789" checksum="E950A9029FE97882" modified="2016-11-02" version="1">MTSPSTPSLGTPPPPPATARPLQGRIAIVTGSSSAIGAAIALALAAQGCSLFCIDVTPTPPRQSQGQGKDHGHGHSFHSTNHASTPTTSTTARDQPGTHERIRHQGGEATYHKADPTRARDMDLAIRACVAKYRRVDILVTNTSASASAANAATAANVSMHTRPLRCHETTDEDFDRALAVHARAPFLACKYAVRQMLDGQPRRYARARGWIVNVASSLLLPLPLLLHQGVGSMGAVSAGAGAGAGAGVLGIGMGMGIGVGVGSPGSCAGQAAAVMLTRQIALDYAADAILCNALCPGFVDAGTGTGSSTGTAGMATGSSMATPSTRTAPSGAMEPGTATATATATATVNVNVNANVNAHGHGHGRRSHQTVSGQPQSREDVADVGSDEAEDNDYDYDYDHDNDYADGSPHSESKLDHHPPPPPTSPPFGGRLGSVEDVARAAVFLCGDDAAWITGVVLPVDGGGSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2G0</accession>
    <name>A0A1C1D2G0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_02929</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2G0"/>
    <dbReference type="STRING" id="86049.A0A1C1D2G0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02929"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05042"/>
    <dbReference type="OrthoDB" id="4222821at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT54952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="480" mass="51560" checksum="386818DE54EA5F1B" modified="2016-11-02" version="1">MSPPSVTPVPEMPVPEPSSNGAALPREIEMAEHPPFPLSPPRPPTTAIGAANSSRACDSCKSSKTRCERISEAAPCHRCSKTNRQCVVGGVVLQVLAPTDSDMNHPGKGPASPRTWYARKTCDPCRASKVKCERASESTKCDRCSKTGRDCVTTPGSSSRHAPQRRQASPLQARPNTSLDINAAGTAAATDTPLLLPTLANYLGAEGRWSGGLDQDSRAAGPFDTPAEALQNGVAGKITRQNYQAKLGDLQREVLADLELVKYCKVADKCPEATLPPELGYNSSFLVGRMLAQSKTLLEILDLFGPTALAPTPSSEGCAPDGISTTNASVRCDVPSMFSLFSCFVCLVRIYRTNFSTILDSMPALFGLQRPVPQLFPGLNLGGFSLENRLDLQAQLLLQVSNEMLSNLKAKFGIAEVGGLASKSVFEPEKTRMLVAMLEDEAREQPPLHEPRGHCAPLTEILENLRQIIQAENAKRRQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2S8</accession>
    <name>A0A1C1D2S8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">gatA</name>
        <name evidence="13" type="ORF">CLCR_02907</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2S8"/>
    <dbReference type="STRING" id="86049.A0A1C1D2S8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02907"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05175"/>
    <dbReference type="eggNOG" id="KOG1405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT55087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="518" mass="57437" checksum="A146283F82046409" modified="2016-11-02" version="1">MASLVRNPGGLRSICRLARAPLRSTPFRALATATETRNAAAAAQATVETPPVETAFLPDEPVGPRVSTPIPGPKSQKAITELHRIFDTRSLNMLVNYQQSYGNYIADPDGNVLLDVYAQIASIPVGYNNPTLLLAATSPDMASAIINRPALGNFPQHDWASILETGLLRAAPKGMNQVFTGMAGSDANETAYKAAFMWKRQQERGGPDAEFTAEELESTMKNQKPGSPDMSIMSFKTAFHGRLFGTLSTTRSKAIHKMDIPAFDWPQAPFPVLKYPLEEHVKENEAEEKRCLEEAEHIIKTYHNPVAAVVVEPILSEGGDNHASPAFFRGLREITRRNNVLLIVDEVQTGVGATGKFWAHEHWNLQDPPDMVTFSKKAQTAGYYFGNPELRPNKPYRQFNTWMGDPARAILFRAIINEIERLNLVENTAHVGDYLFSNMERLAQQYPAQFRNLRGKGRGTFIAFDNPKRDEFLAKAKTLGVNIGGSGVSAVRLRPMLIFQKHHADILLDAFEKLAKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D334</accession>
    <name>A0A1C1D334_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myosin type-2 heavy chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">myo2</name>
        <name evidence="12" type="ORF">CLCR_02717</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D334"/>
    <dbReference type="STRING" id="86049.A0A1C1D334"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02717"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05161"/>
    <dbReference type="eggNOG" id="KOG0161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055914">
        <property type="entry name" value="DUF7491"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24319">
        <property type="entry name" value="DUF7491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="11">
        <location>
            <begin position="120"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="174"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="750"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1140"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1140"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1165"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="267"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT55068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1355" mass="155929" checksum="E7CF4BEC894A61B0" modified="2016-11-02" version="1">MLLHDRSPDTSPFSGHSQRPFTRSVHSDLSIQTPMSSSSYNKSLLFASPTPTPTTASRHERQHSYSPTASFSSVPSHMRNNSLQRQASSSSTFAPKFIKSEEMRKSEDRISAIEGENDFSGKRYVWVRDPEKAFIRGWITEDLPGNKVAVQFDNGSSIEADVDEVDKVNPAKFDKADDMAELTHLNEGSVIHNLYTRYQADLIYTYSGLFLVAINPYCPLPIYGNDYIRMYKGQAREDTRPHIFAVSDAAFRRLVEEGENQSILVTGESGAGKTENTKKVIQYLAAVATSDLDTPVTGRTPGKQLSNLSQQILRANPILESFGNAQTVRNNNSSRFGKFIRIQFTRSGQIAGAFIDWYLLEKSRVVKVSQQERSYHVFYQLLAGADQRMRDSLLISGMDVEDFAYTRAGNDTIGGVSDRDEWNTLIEAFHIMNFSEKEQMAIFRTVAAILHLGNVGVRQESRATDQASLTTEARASVDKACRLLGVQSEPFVKGLLHPRVKAGREWVEKVQTPEQVRLALDALSKGIYERGFGDLVSKINNQLDRGGVSSDDSHFIGVLDLAGFEIFETNSFEQLCINYTNEKLQQFFNHYMFVLEQEEYAREQIEWQFIDFGKDLQPTIDLIELPNPIGIFSCLDEDSVMPKATDKSFTEKLNSLWENKTTKYAPARTRQGFILTHYAAEVEYSTEGWLEKNKDPLNDNLTRLLAASKDDHIANLFSDCVDEVDEPYSPRSRVKKGLFRTVAQRHKEQLSILMRQLHSTQPHFVRCILPNHKKKPKQFVAPLVLDQLRCNGVLEGIRIARTGFPNRLTFAEFRSRYEVLCKDMPKGYLGGQETAKIMLNRLQMEQSNYRVGLTKVFFRAGVLADLEEQRDALIREIMSRFQSIARGFMQRRMAFKQLYRAEATRVIQRNLNVYLDLQDNPWWRLLVRMKPLLGATRTASEVKKRDEKIEQLQVKLKQDAAERQRVEDERRRAEIEAHRIQQTLDSERALALDKEEIFKRLQYRESELSEKLAEALTEQEALEDQLDEAIDSKKKTEEELTTRREQVLQAGQIITRLEAEKKDLQRQIDKLEDELEHVEKTHTQNDDRLQTISQELRSLKSNLSVKDRKISELEASLQQAEKDKESRASSLEQELRSLKSQLAHRDRASEGLEQELRSVRSQLAQRDRATEDLEKKLHRAETLRTEESRRQAEDFDVQIRALKNELNQKDRKLQDLESTLSKIDQDAEAKLARTADELDQSKKLLRELQGQNDELRKQVTATALATSKHQENLRRKEGELSALMADVEQHEREKLELRRENERLADGFEDLTTKKREALAEMERLREQRTRMEREAVEVRRCLEKVMPFFTQHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D3D5</accession>
    <name>A0A1C1D3D5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RSC complex subunit Sfh1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_02840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D3D5"/>
    <dbReference type="STRING" id="86049.A0A1C1D3D5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02840"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05138"/>
    <dbReference type="eggNOG" id="KOG1649">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258327at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="502"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT55045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="614" mass="68462" checksum="969805ED045109E3" modified="2016-11-02" version="1">MAPAQAYVTSYPPRIRQYANTLLQPVLQTQNVAPAGRTTKRGTTIINYADDAYDEDDFEDSEGPRRPTGLRSLRREEVEKKEPQNEKLGRELREPVDLQPIYRDWMIRRTVRPTIDEPNRTDAQAHIQSQLPLTLIPIRIDLDVPAHQPDAPFPLSRTDVGINPSLPMFKKPEPLPGYKIRDIFLWNLHENLLTPDDFAQCFVRELDLPNQTALAMNVSQQIRTQLEDYAGVAMHPLFHTQQKRSQMPDANSVPTPSGIANGSSRGGTPRPIRGASIPRPSSTTPGTPAVSTPMPMTLTNGASVAAVASPLPPAPPPEQTDESEDPYLNPDDTYRCIITLSIYLSSRLYQDKFEWSLLHPSGAAEAFARQTCADMGLGGEWVMAITHAIYEAVLRLKKEACEGGMLMLGGNAFGGEIDNQAVRHEESAGWRYDIDDFGAEWEPKFEALSKEEIEKREGDRERQLRRLRRETAKFSSTAGMVPSAREQEAQQRGSYFDYANIGNGGAGDETPQMGRGERSKKKRRFRSLSPVAKAQTPEAGSSAGAGWGGEGNRLQEYERQNWRCKHCLIWGSAVWAVRDGPLGPRVSRILPSLNTVGYLANDFADTVQFLWLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C690</accession>
    <name>A0A1C1C690_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_00107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C690"/>
    <dbReference type="STRING" id="86049.A0A1C1C690"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00107"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02004"/>
    <dbReference type="eggNOG" id="KOG2565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF79">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="388" mass="44744" checksum="1425C2255DB2B0D8" modified="2016-11-02" version="1">MGISPFKIDIPEHEVDRLKRKLQDTRLPKRPIVPEAGSDYGPPIDWFQRLHKTWLHEFDWFSVQKHLNRHDHFIADIDDETFSLRTHFTHTRSSRDDAIPLILIHGWPGSFHEFDRVVDAFTNPEDPSQRAFHVVIPSLPGFCWSSPPPRRGWTMKDTARVFNKLMNQLGYSTYVVQAGDWGSFVARELGANFEECKAVHFNFCPVELDEGITGLTPREKVIKQRQQDWLDNHLGYAVVMRTRPHTIGVALTDNPVGILAWVGEKYIEAVHPSKLDPPDPAWDQAILTTCSLYYFTDCIMTSSLPYFEGIKHADFGNFFLKKENYVSVPMGYTSFLYDTRPGTERTVKQTGNVVFYSECDDGGHFAALERPDVILRDCRKFFGQWFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6G2</accession>
    <name>A0A1C1C6G2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">pps1</name>
        <name evidence="22" type="ORF">CLCR_00122</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5 18"/>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6G2"/>
    <dbReference type="STRING" id="86049.A0A1C1C6G2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00122"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02006"/>
    <dbReference type="eggNOG" id="ENOG502QPJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016271">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000852">
        <property type="entry name" value="Phosphatidylserine_synth_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OCT44042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="249" mass="27146" checksum="73C0306A0527AC5F" modified="2016-11-02" version="1">MSRRAGTTNTGQKESASQPEDKTQSKQVMLLSEDAGHFSLIRALHLADLITELNGFCGFMSVLSSMRYCLSDPGDLTNLWLAFAFMPFGLFFDFFDGKVARWRKKSSLMGQELDSLADLGLTGESQVTFGVATAAAGFAIGFRTSVDQILLSFYVLCGLTRLARFNVTVAMLPKDQSGKSKYFEGTPIPFACLTSSSIMATFTFLGLIHDSLPLGTWFTGTALEFHPAAAMFIVNGCLMTSRTLHVPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6R9</accession>
    <name>A0A1C1C6R9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Meiotically up-regulated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CLCR_00549</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6R9"/>
    <dbReference type="STRING" id="86049.A0A1C1C6R9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00549"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01157"/>
    <dbReference type="eggNOG" id="KOG1012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="239"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="464"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="653"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="93"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1043"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1063"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1092"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1122"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1150"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1175"/>
            <end position="1193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT44234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1240" mass="138249" checksum="FD69BACEEC02793F" modified="2016-11-02" version="1">MAAQQQKSGKPWSGTNRIPNIKEFVDRLDRDKASRDKDIDAHNQGHQTQKYSSEIQPHKNEKPKTEGKTVTDPVTGNQVVIADVGKEYMERADNPQLSVPNQNLGKPTTVGTDPSQKNPEYKEKQDITAPPDPIAEGSTSDVPIHGEKTNILFHPTPSVSYEPMFEALEKRAGGLCIAILLSVVILGKMFGGSLKGLIPLGMCLASGIWLWMKEVIRSGREVEWSSEQSRGETAVANLLPESVEWMNTFLSIVWGLINPEMFAAVADTLEDVMQASVPGVINNVRVAEIDQGSNPIRILSLRALPDSRMHELKQSIHEENKKTKDPQEAAADEEGGDYYNLEISFAYHAKPAGASASSRARNMHMNLVFYLGIKGLIGVPLPIFVELQELVGTVRLRLQMTPEPPFAKSLTFTLMGVPHVQAGCIPMIQKGVNILNLPLISNFVNYAIGAAASMYVAPKSMQLDLKSMLQGDDITKDTQAMGVMWIRIHRAIGLSKQDRRGSKHGGSDPYINLSFSKYGKPMYCTRVITDDLNPVWEETAALLVTPELIKADEQLSVELWDSDRNSADDMVGKVELSMQKMIQHPGKMYPQISKLAGTQQGTEMPGELHWEVGYFGKPKFRPALRTDGKDKSLPEHLKNDEKFQDEKGTIDNEDADAVAHTPPDPLWPSGICSVIVHQIVNLELENIKGSNGNRKGREFEPAKAYGEGTDEESNKLPTSYCTILFNDALVYRTRAKAVSSKPIFNAGTERFMRDWRSGIVTVTVRDQRNREHDPILGVVPLRLSDILTTSSQVTRWYPLDGGIGFGRIRISLLFRSVETRLPPNMLGWDVGTFEFISDRIVATGWKSNTKLKLRTGGSTGKIPRTHCHSNEAGDGVYFDVSTEANNHVRLPVKYRYRSPVVFEFHVTGKRGAAAYASLWLQNLVDNEETTIDIPIWTTKNGNRLVQNYITEENVKAFMDKGLEDLQEVGRLQFRGRFKAGMDESHREYVVDNDTRETYETFEACLTEGVRNRVVESEVPEQIQELHEASLQQGRDILNKELSEREKRKWRSKSGEDWSGAFSHDPRAYTNKNHEKIAEPGTDEPPHDPFNPSDDDDDDYEPIDDDSSEDLGITDATNAQEGQFRKDPKDVRGLDGNSDEPNGYANGRPSADTTGTAGTDYTTMTETSTNSVQPVQKRDSTFEKKAGKRSEERKHRGLSQWKPARNVKFAKDEAKIGMGKLKQKLGMGGLNGREPGVETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6S9</accession>
    <name>A0A1C1C6S9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">MDE1</name>
        <name evidence="9" type="ORF">CLCR_00697</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6S9"/>
    <dbReference type="STRING" id="86049.A0A1C1C6S9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00697"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01167"/>
    <dbReference type="eggNOG" id="KOG2631">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191080at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="8">
        <location>
            <begin position="20"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="235" mass="26568" checksum="5F0020D7C764AAED" modified="2016-11-02" version="1">MADLGNDHLVQSDDPEHPANLIPRLCKQFYTLGWVTGTGGGTSIRKDEYVYIAPSGVQKELMKSENMFVLKYPTPKYPPSAREYVRKPRDLKPSACTPLFLAAFERGAGCCIHTHSQWAVLVTLLVEKLFGREACFEISNIEQIKGIPKGPGKGMLGFHDTMRIPIIENTPFEEDLTEFLEKAMEQYPDTYAVLVRRHGIYVWGDNVAKAKTQCESLDYLFQLAVEMHKLGLPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C773</accession>
    <name>A0A1C1C773_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">tim50</name>
        <name evidence="18" type="ORF">CLCR_05681</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the TIM23 complex, at least composed of TIM23/timX, TIM17/timQ, tim50 and TIM21/timU. Interacts with preproteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C773"/>
    <dbReference type="STRING" id="86049.A0A1C1C773"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05681"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07009"/>
    <dbReference type="eggNOG" id="KOG2832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="287041at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="17">
        <location>
            <begin position="302"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT44312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="586" mass="66288" checksum="E1653B75CA6AB253" modified="2016-11-02" version="1">MLRRAALPLLRGRTGIRSPILQAQVQTQLRYYAKGDRPRDPGYQAPESTKQPLPQKEPLRKVPFVQSTPSPNAESASPPSTSPSSDASGKPESRPDATPFGEDPARDLDDVSESVSRASGRSLRQEEGRPREVERDATGQEPTFTSEPREADPAQQPLPDLTKGIPSTLDAELRNAQSRQAAAHASSLNITEDPAEELPAGARGRDGGDTPREEYVSSSDRRKNAAFRYMYIILGLGIVGGSIYMGRNWADEEEEKKHQDAPSGWGFTHFYNRVTARLGDMMSYYRDPVTTKLLPDEDPDPNFRFPFVLVVSLEDMLVHSEWTREKGWRIAKRPGVDYFLRYLSAYYEIVLFTSQPSAVVDQVIRKLDPFSMIRWPLFREATLYKDGGYIKDLSYLNRDLKKVIIMDTDPHHVKHQPENAIILPKWTGDPKDQTLVQFIPFLEYLATMGFEDTREVLKSFEGTYIPAEFARREKLLRAKFEAEQADKGKKRPKKTLGALSSVLGISGRSPDGLDSGEEGKMLWDQIRERGQKQYMELEKKIQEEGAKFLADREAEEKKYQEEMYKSMKPTGWFSGLLGGGQKEAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7B5</accession>
    <name>A0A1C1C7B5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF521 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_05714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7B5"/>
    <dbReference type="STRING" id="86049.A0A1C1C7B5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05714"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07055"/>
    <dbReference type="eggNOG" id="ENOG502RQJN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2594507at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01355">
        <property type="entry name" value="AcnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01356">
        <property type="entry name" value="AcnX_swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012047">
        <property type="entry name" value="AcnX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007506">
        <property type="entry name" value="PMDh-L-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002840">
        <property type="entry name" value="PMDh-S-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36577">
        <property type="entry name" value="DUF521 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36577:SF3">
        <property type="entry name" value="DUF521 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04412">
        <property type="entry name" value="AcnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01989">
        <property type="entry name" value="AcnX_swivel_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036630">
        <property type="entry name" value="UCP036630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphomevalonate dehydratase small subunit-like" evidence="3">
        <location>
            <begin position="24"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomevalonate dehydratase large subunit-like" evidence="4">
        <location>
            <begin position="155"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="61167" checksum="AE650383D72B6F97" modified="2016-11-02" version="1">MRIHGRPLVAGIASGEILVSDTSISFWGGINPDTGIIVDQHHPLRGECVTGRIFAIPSGRGSCTGSGILLELLLKKRGPAALIFQHVDEILTMGVMVARELFELSIPVLIISMDDFTSLYSGTPASVDGPQLSFDEPPQIPKTHSPSTILRPVHIKLSPRDERFLAGDFGLAAKLAMEILVDVAGMQSAEAFLDVSQAHIDACIYIGPASLLFAQRFLSVGAKFAVPTTLNSISIDQRRWREIGMNPTLAREAGKLAQAYMSMGAMTSFTCAPYLLETAPKAGENIGWAESNAVVFANSVLGARTQKYPDFLDVCIALTGRAPAAGCHLEEPRLPKLKIKVAALSDVDDAFWPLLGYHVGKLAGSDIPLVCGLEDTSPSRSDLKAFSAAFATTASAPMFHMAGVTPEITEAGDPSLEIPCCEIGKFELRSCWTQLNTATDSSLGLVSLGNPHFSLEEFATLVMLCSRRKKHRWVEVVITTSRAVSEQAAEAGYLDSLESFGARVITDTCWCMLDEPVVPLHATNIMTNSAKYAHYAPGMVRRGVHFGSLSSCVDAACSGECASAIPNWLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7H8</accession>
    <name>A0A1C1C7H8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7H8"/>
    <dbReference type="STRING" id="86049.A0A1C1C7H8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05789"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07116"/>
    <dbReference type="OrthoDB" id="4851482at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="521" mass="58793" checksum="27A70649AA05F7F3" modified="2016-11-02" version="1">MASAQQVQGHNPSTCPELVAAANAQQKADLVRLDHEQLGKAQRGVTPFLNLHLSDLAASAVLMLDDNRDTLTYFDSELEAEKYRERLLPMKPQPDLTIPQTAAEKKAHVRVLFQAFKCVPAECLEGENIKKPFTNHIHDNVMVECLCWEILRRCIQRSQVLSNLVETYEPDKYKFKKFMDKDFEQRFDAIVNAMARSKSMCKHMYDVPYLFKVIDDPQTNVERIDSNRKLNGQKAVVMKRGKEAVAGDEQQGRSKKPKTEVAKTELQSALVPSQPRHQHALPATSATQTSMYTPDRQLFSSQQAVSAPPPRRMAPPVQTWYGQQDLRQIGNRTYNGRYHTNNYSPSAYMPSSQYSVQPLSQMRTQGYAGRPIMRPYQSQATSASSTTRSPSRTSSQYPDPSTPSDQMAMGWLAQPEPDNRTMNSSYHSSASTITSPLNTIDQEQPQWPGDSYQESDLGEICHASSETHTQDDGFESHHEYAHANIEEFLQRAEEQNASNGAAAESYEDAPFETDHQEPSHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7Q2</accession>
    <name>A0A1C1C7Q2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Aspartic proteinase yapsin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">YPS3</name>
        <name evidence="13" type="ORF">CLCR_05759</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7Q2"/>
    <dbReference type="STRING" id="86049.A0A1C1C7Q2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05759"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07243"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF12">
        <property type="entry name" value="ASPARTIC PROTEINASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="98"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT44564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="527" mass="56266" checksum="643D695C35EC6FFE" modified="2016-11-02" version="1">MPLPRAMVRLTPQRRDQNKDGDEVLLLGISSADCIYQQKVPPYTMKKLLVLASLFAAVSAKTVKLDFWKNKPSHKSTLPRRSDHFTSPVTGDDYQILYLIDVNLGTPPQPFSLLLDTGSSDTWVPSTDASICVYGGCEHGAYDKNMSSTYSLVEEGTFFLQYADLTYAKGDYFTDVLSFSEAVSITNTTMANANDTDNTQGIMGVGFRKNLASLRNGEILDFPTVPEQLKAQGHIDRVAYSLYLDSSDDNRGSILFGGIDPTRYTGELVALPLSTDQDGEYSEFRVALTQMSIHDGNSTRALTQPSFNKPALLDSGTTLSNLPQDVINVITEGLGATLDEDTATRYVPCSYRQSNASLVYTFGGLDGVNVSVSLSELISEQLGDESMYSDGTPACALRIALAGDGDVILGDSFLRSAYVVYDLENFVVALAQAKVDNKAPDDDAAVTAISSGTALPGVTRTATVTASPPPTDLGTAATPTFDLPGVTIISTATAEAQSPSNAAGAIRMSRAAGAAMGFGVVALQLWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7R8</accession>
    <name>A0A1C1C7R8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TRAF-like signal transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_05753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7R8"/>
    <dbReference type="STRING" id="86049.A0A1C1C7R8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05753"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07183"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="7">
        <location>
            <begin position="141"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="141"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="539" mass="60369" checksum="ACFF089DCBC2274C" modified="2016-11-02" version="1">MDDDHDLPVSDFGLDSPSPLQSQFNSLFAEFARSRPHVSPPRSPSARQSHHDRPKAPEQAEQACLDLRSLEYAEDYDSHLMCPICHVPFVDPVVLECDHTFCESCLHEYRQGGQNGQHNQCPTCRAFVLSISRKASRLIVNMCNEVKVNCPNEDCGQVLPRGYIERHATRECPHQRLKCPDARCGKLVKRRNFVPDQCIHSSHIECDCGAVIELGKGDWLRHKDEDCPNTGVKCKQCGQRISARDYLNGVTGHICDKDHFCPGKEYGCTDDVGPEELDHHVRSCPLARMAPHLKKQSQLLQSLQEQLAMVKVRNEVLETGFDKINDIVNDRVLPHIDHTDRSPPPESDIEEIERDHIPSAISHRDLLMPAHLRALTPSPDPLASTVSQTEQHLLALHESLRGTVDTLENDITVMASNIADLDARTSMQLMNETLRIKEELAHTNAALFSTRSQVQWLLNRERIGQQQQAMGMRGRTPSVQPHSTNLEPSARSSVSGNTDHSAQGSSSERQPSPGFVASSPNFRPQMRRPSGGSQERVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7W0</accession>
    <name>A0A1C1C7W0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7W0"/>
    <dbReference type="STRING" id="86049.A0A1C1C7W0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06141"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07229"/>
    <dbReference type="eggNOG" id="ENOG502SAQI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5327148at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="3">
        <location>
            <begin position="12"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="268" mass="29627" checksum="78187E31F0BE1C53" modified="2016-11-02" version="1">MLFFPKKLAGAGYVVLNVIRVMNIIALLTVIAASSVMLVKTFIVSKFFFFDACEHIIRVVMSGFLILTELSLFKSYISKNWPLFSPRSSFVMLGVAMIFLGNSVLGNLNKQATSEESIGLPFWRLVIASGIIVFVMGFVNLFASFIFRDTKAHLTARQVRSHGAVASHKADVEAFTPKPPSRKSHYRSFFLGSKRDTLPSYSRKNDVMVETPKMHLAISSPFPQTAQSPGASSSKYSASPKSERYAMSPELSRPDPAHHPAVTHGQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7X2</accession>
    <name>A0A1C1C7X2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_06096</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7X2"/>
    <dbReference type="STRING" id="86049.A0A1C1C7X2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06096"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07236"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000103">
        <property type="entry name" value="Mitochondrial glycine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="15"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="127"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="235"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT44558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="334" mass="35344" checksum="BA29338F886A9125" modified="2016-11-02" version="1">MSNGGAGTIQSSKKAHPTFHFFAGLTSGVSSAVLLQPADLLKTRVQQSHSSSLVPVLRSILSGPHPIAGLWRGTLPSALRTGFGSALYFTSLSSLRQLLANKTAAATLGNGGAAASTGKSSSVLPKLSNTQNLITGATARVFAGFILMPVTVIKVRYESDLYAYKSIASASRSIYASEGLKGFFSGFGATAVRDAPYAGLYVLFYEQCKTHLNKMFAAEQTAALDGLEGRPSIASSATINASSGVLAAGLATSMTNPFDAVKTRLQLMPQKYGNTLKATRLMLKEDGVKAFFDGLGLRMGRKALSSALAWTVYEELIGRAERFVARREEERALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8G8</accession>
    <name>A0A1C1C8G8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_05581</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8G8"/>
    <dbReference type="STRING" id="86049.A0A1C1C8G8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05581"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07506"/>
    <dbReference type="eggNOG" id="KOG0137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adaptive response protein AidB N-terminal" evidence="7">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="6">
        <location>
            <begin position="185"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="5">
        <location>
            <begin position="308"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="71291" checksum="D7C44B652E9604AD" modified="2016-11-02" version="1">MAPLEASTVDKGFILAPPPLANPFTSDRSYQRILEWYLPPDVLQKVIPRLSKFAGESVSQEVNDLISNAESEQPHVKTHNVWGARYPYDRLVTSHGWKELGKWGSKNGVIALGYEEEFQQYRRLVQHAFNYTFSASSAVYSCPVSMTSGAARLVAKQLDSVPADHPFHEIYRLLTAREGNWISSQWMTERPGGSDVQNSETVAVYSPLPHKTGRFGSIEEGDYLVSGFKFFSSATDCNIALMLAKTESGQLSLFVAPTRKTITVQGQRQEVTNGIRIHRLKNKMGTKELPTAELVLDKVRAHLIGPLDRGIATIALLLNVTRTHNFITALSCWRRGMAIAKSFAKVRTTIDQPLATFPMHLRLLATMEVKHRGALQLAFFTTSLLSFVDNGFPAEHVERRGYVPLPSPGEQAEVILRTLTATVKAVVCKTATLALQECQEAMGGVGYLDEPEEPEFNISRLMRDTAANMTWEGTTNVLSSEVVRHLLNKDARHLSSFGDWVKQATAHVRDAELKKTLDRAWTEFSGTLESKRADMVSALAMGRQLMFSLAWIVAGVLLALDAERDGDAIAMEIARRWVLEGEGNVGEFHLPRVVRVSERALGIGDRERINWDCRLVWGCDLPADATKGYRVNPEEARSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8J3</accession>
    <name>A0A1C1C8J3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8J3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05804"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07455"/>
    <dbReference type="OrthoDB" id="3469225at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT44779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="480" mass="54188" checksum="788AFE9E48FC7E90" modified="2016-11-02" version="1">MQAPVLTVSITTPQSWAQQNAIKRRRVMRSPRRGIINLKHLDPKARKAKEEMLVKAVEGQLQIKKSPTNGLLLDPFQTFPIPMAGCHGTAFAFEGHTNPYLSLLWPHALKSAIYFEGLVALCRATYLAASGQSARGDRHFVWHKGNVMTKLRARLEDPQLCSDDTTILVVATLGTIDYILGDHSAACAHVSGMRQIVKIRGGFKTTSPWERLLKTNVDAYEALWSFLFAADSSSDKSPRYDGQILQNAEFPIYMAHPFKPEVCEMLAKLPQGFCDIGLTGVLSLQMIRLLSDFSGIKAKMADSPRTGGFDTISRRKIQTTLEDLHRLATLQTTPTERFLSHGLVAYCYLLRIIYFQDHLTGFYETALKALADIALNQTPSHKSPDRKCFLWSNMMIGTVLQHGQVRPPGWTAVLRQFFDKYGEARQWKKLEADLKLFFLGDDIHQFAKEAYDEAVRRRERGESEERDSRVATMAIRNVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9K7</accession>
    <name>A0A1C1C9K7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9K7"/>
    <dbReference type="STRING" id="86049.A0A1C1C9K7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06085"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07870"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="102"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="304" mass="34426" checksum="25B902EBBED546E5" modified="2016-11-02" version="1">MTDLAPHRFKRRYVLALFAAFAAALFDLTAAIANNGTYDPSVQEYYTSLESRLGYWLLLGNTRHCGLYPKGQLWPFPVGKAQRAMEDYLFTRLDLKPGSRVLDAGAGSGYVAMRMAEKGLTVEAVDITPLHVEDARRNVKARGLQDNISVRLGDYHNLTDFDNGSFDGIYTMETFVHADDPLKVLQNFYRLLRPGGVLVQNEADFNRNSELLQDVLRLSHCQNTLEEGVLIGMLEQVGFKDVQLDDLTDEVLPLWRLFGVIGYIPYRILRVFGLHTRFTNLMAGVESYLHWGEGRYISVRAIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9M7</accession>
    <name>A0A1C1C9M7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9M7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06247"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07806"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="192" mass="20976" checksum="CB718668753E6A17" modified="2016-11-02" version="1">MAIMLIGSPFISLGLQRFPTLRRMGGCAGLAIMFSGLLIASSTDSSTVLLWTQGVMYGFGALLVYFPAMFLIDEAMARHWVGIWVIAFHPELGNEPGIAGESPKELEDVVDYYSRRSSSTRKKLGTASQVVAIEVTGGGQHAILQYCYEPDDRDYHCKLRTDAKPVAVLRASHRRSSQVTSATGRTEPAYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9T6</accession>
    <name>A0A1C1C9T6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9T6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06428"/>
    <dbReference type="OrthoDB" id="4153464at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="108" mass="12123" checksum="97290C7E458D866F" modified="2016-11-02" version="1">MGTKADGHSSSSAKRGQNEHDLKEEQKRMRNRLSQKVIRERRSAYIEQLEAKVAFLSRHEPDGPSSELWQRNEALQDSLHTLRKKLLSVSTTIIGLADGVLPALNTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9U4</accession>
    <name>A0A1C1C9U4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase delta subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9U4"/>
    <dbReference type="STRING" id="86049.A0A1C1C9U4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06182"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07892"/>
    <dbReference type="eggNOG" id="ENOG502SC9I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337486at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="236" mass="26602" checksum="72C338078E5D4301" modified="2016-11-02" version="1">MPRGRKSATARASSGGQSRLSFNNRVTKTSAQAQRDEEVASAKKISQIEDSLQQEQPEPEVVDVAVKDEPELGPTQQKIENNEQQETEQIVEEEPEPSKASARRRVKAVKGKDEREIAAEKITDAQLRKYWQKEEDSRLAPRVHQETLPLHEKILRHFDLSSQYGPCIGVPRLTRWRRANTLGLQPPIEVLAVLLREEEGGDAKEEMHYGRKGRSQGCGKMAYIDELGSGRVVLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA07</accession>
    <name>A0A1C1CA07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MRPL51</name>
        <name evidence="8" type="ORF">CLCR_06373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA07"/>
    <dbReference type="STRING" id="86049.A0A1C1CA07"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06373"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07989"/>
    <dbReference type="eggNOG" id="KOG3445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="139" mass="15346" checksum="3D391EE71607924B" modified="2016-11-02" version="1">MGVQGVKTVSTARNGLGAYILQCTRLSLTYSDHWVSSTGLLSLLRSPLFPSLTHRYPSVEFRISPIPNRHPVLKAQYVNGRSKAICVKNLSKEQVAEKMEFLLGNSGQKNVRVGGKKVVSQNESVRGVWSPMHGVIKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA67</accession>
    <name>A0A1C1CA67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA67"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06499"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="74" mass="8499" checksum="303C21CB472F1686" modified="2016-11-02" version="1">MHKRLLFGEELYPQYSPTGDARQPDANTSHTTTDSRQQHFVPVEQRRGGEKTQINAQHRRQFRAVGESAPLELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA68</accession>
    <name>A0A1C1CA68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA68"/>
    <dbReference type="STRING" id="86049.A0A1C1CA68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05643"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08001"/>
    <dbReference type="eggNOG" id="ENOG502T4Z4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4159529at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="570"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="634" mass="74443" checksum="3BC6A855179B1262" modified="2016-11-02" version="1">MEPPPPPDHHFAPIDPHMEPLHDFVEDRFVDDPIHYEERIPNVQQRLDRLSLDGDVPETRPRAERLRSADLLPLPQDYLYYRLSKRGDDWSSCVKKPIPAPIEEIERKAKRSKGGDAPILEQLTKMPSLRRDMLDEVVRKANDKESGDAYWEVVYIKSKRVQTRRGKMEVPEMDVILARTRGRAKSRTKSFANSGERVKREVVKEKQYISDSYGRARKDSVMDKLEDPVANLPVFEADGRPRDDLGPMHFNNSNLPPHIAREMPLGTKLEKKKEKAEKRRRSRSRSKSRDRGVVHHEDGVFVVPDVHDFAGESADPATVDGMLGDEPMDRRGRRGQSPHEHPVVVEEDPRRSHSRHRPDGRSKSRPRKESVHFPNGRTRQYFDGGDGSSENSDTSHYGFVGEYESSTTSISTPGAIPRRGSLARGGRPDVEYKKHHPGPNRRLSYQEKPYHGEQHVILPVRPARRNSNAIYHDRPPEGRYERPSSRLVRRETAPPIPEDHQIVYHEPLPRTSERDLVPLRRSYTAREPILHQHPRDDEELYYRDEVDRQSYRAEGYQRDRVIEDHFNRREQELSARERELEIREDELRQLRRQRERELDRDREYYDDRDVRKERRESRQIFFDPKTGQAYYYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA84</accession>
    <name>A0A1C1CA84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">msp1</name>
        <name evidence="22" type="ORF">CLCR_05473</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA84"/>
    <dbReference type="STRING" id="86049.A0A1C1CA84"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05473"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08071"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030061">
        <property type="term" value="C:mitochondrial crista"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097002">
        <property type="term" value="C:mitochondrial inner boundary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901612">
        <property type="term" value="F:cardiolipin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140523">
        <property type="term" value="F:GTPase-dependent fusogenic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180020">
        <property type="term" value="F:membrane bending activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097753">
        <property type="term" value="P:membrane bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097749">
        <property type="term" value="P:membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990627">
        <property type="term" value="P:mitochondrial inner membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990626">
        <property type="term" value="P:mitochondrial outer membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650668" description="dynamin GTPase" evidence="19">
        <location>
            <begin position="18"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin-type G" evidence="21">
        <location>
            <begin position="157"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="20">
        <location>
            <begin position="723"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OCT45443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="837" mass="92575" checksum="BE9A0ED66700D3EB" modified="2016-11-02" version="1">MARLPAMFGASVLAGLAYIQYQAQQAGTYTMNILRKAGEAVTETSSSMFEGAKGIANQIGAGWERTKEDAHLPAWLQQFFENGEDSGEGGSGPEQPNSTNAAAGVAAASGLAIGVEQSDEDEDRSEAHIAKDDQMMLLTRKMIEIRSILNTIGQGGALTLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGSNMVTRRPIELTLVNTPDAKSEYCEFPALGLGKITDFSQVQRTLTDLNLAVPPEQCVSDDPIQLTIHSPNIPDLSLIDLPGYIQVVGKDQPVELKQKIADLCDKYIQPPNVILAISAADVDLANSTALRASRRVDPRGERTIGVITKMDLVDPIRGVEILSDRKYPLRLGYVGVVCKIPHQTSGLFGRTGANVTSAVVKNENAYFSSHPLQFGPQSEVAVGTTTLRHKLMHVLEQTMAASLAGTRDAIVQELEEATYEFKVQYNDRPLSAESYLAESLDSFKHSFKEFSEQFGRPQVRALLKEVLDQRVMDLLAKRYWNKPVEDLSPMQPEADPLSELPKADPNSLYWQRKLDASTSELTKLGVGRLATTVVAAELQSHIDKLIAASTFASHPFAQRSIVDASSSILNDRFYSTSDQVENCIKPFKFEIEVEPNEWSKGRENVGRVLKNELKACEAAHRQLEDSIGKRKLKDVMGFIDRVRKGDVVLEGDGTGGAGGFSSALLQKGREAVFLRDRADIIKMRLLAVKSKQCANLKNKYYCPEVFLDVVADKLTSTAVLFLNVELLSEFYYNFPRELDLRLGRHLDQSEIERFAREDLKVRRHLDVIKRKEMLELVLEKIESLRQLEGRAKKEQAKAVQAKERGRWSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAT3</accession>
    <name>A0A1C1CAT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative amino-acid N-acetyltransferase subunit Mak10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_01430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAT3"/>
    <dbReference type="STRING" id="86049.A0A1C1CAT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01430"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03462"/>
    <dbReference type="eggNOG" id="KOG2343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="4">
        <location>
            <begin position="29"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="5">
        <location>
            <begin position="313"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT45552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="742" mass="83913" checksum="7F77A6C659649294" modified="2016-11-02" version="1">MAHTRIIHPNVQVNEITREFRHAASKLAPGKLIKDEHFTLFEAVSALEIGDPKMDSGCTAFDPESDEEFDPTKALSAEEIIWLMDELMYREVAWQMGYPLSQTLFTSVHIERLLWPEPKRLSDASFWRHDPVPAVIPSLLRDVFQPYCLGLIKCCDLVLSMVTSQHYYEEEDFATQIFNRPLLHDFAVGEVMDSLEAARTWLDRSELSSHLTTALSSRLEARSALLKLFHECECGARPSLSTLERHIALIRTIENSASLGRPTSAVAFTLKIQRRLASSVPPRPMIVVDKEKAFPFLQKLLTDATTAFQMLDISSSCDLLVAYQNFMAQEPQPAVYVRALLQSFLNLNGAVVGRLAFKDFIVHDIGSLVLPGEALLDPGQMDDLPEDQQIELGTRVDLFVDRCSQSFLNLFRTLCLNRCRVRRTMCHAALEWDQIQAEAEDLDGVVQSILNEPAIPYLAGEEPTFSYSFSSWVYHYKLIQLRTVLQMGFELSIYAPHEFAGMYWYLSFLSSTHLNHLERITFFVASRQRPTSLGQQEAQTTLQLLYRHFTWLKAVEAMAKALHRVFTVLQRHGHFRKSTAAYATDALQYELRMRPFLHMSIPEPIDMDVAQQSSSLRGLPDEKLITQASNLVQTARKAWDEVLKGGWNFHPFAQGDSKAEMARGGSSKPPGPVVEREWTQDVRNSMKACIGTGIVVTTLGTLLQTKKSTGTAVNITSLKVEIPPVGDRSRWHVSWPVPKLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBJ6</accession>
    <name>A0A1C1CBJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General alpha-glucoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sut1</name>
        <name evidence="8" type="ORF">CLCR_00037</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000018">
        <property type="protein sequence ID" value="OCT45913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBJ6"/>
    <dbReference type="STRING" id="86049.A0A1C1CBJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00037"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00067"/>
    <dbReference type="eggNOG" id="KOG0637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="400"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="672" mass="74451" checksum="B238F3E11015317F" modified="2016-11-02" version="1">MSRSDQGVDRDERSPLIRGARRNDDIGERTVRGKGQLAEEPYQPEDDYFGHTSSDAIDLEGSESVENKSSLYLILLTVCIGGLQIVWSVELSNGSPYLLSLGMSKALLAFVWLAGPLTGVLVQPYVGIKSDRCRISWGKRKPFMLAGTLGTIAASMILAYARDIVRVTGRFDADAPYVGGYKVGTIILATVMMWCLDFSINTVQAAIRAFIVDNAPSHQQESANAWASRMNGLGNVLGYLFGYLNLPRYFHFFGNTQFKVLVVLASIALSSTVLVSILSIKERNPQLDPPSRDSEEGGILAFFRQVFSSMRRLPPQIRKVCEIQFFHWIGWFPFLFYITTWIGQLYVNPHLKPGMSDTDVERLWGEATRIGTLALLIYAVVSFMANIILPFLVVPSYKPQDSDSDTDSLPPPPMTPITPTTPIGARTPATPWGERPPMSRSGTSQWKPGHRPRTLSRSQTSLSINRPLNTPGLTRLHNTPGLDRLNRRERSETAARWLTMVQIPGLTLRRAWLLAQLLFAGCMWSTLFISTPFGGSIMVALVGISWSLSLWAPFALISGEIAKREERRRKKRRARMANGQDADEADDKEKDEEDQAGIILGLHNVALSAPQVLATLISSAIFKLLQKPRNEPGDTSVGWTLRVGGLAVLVAVFITSRMKEPGDETEDEVISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC15</accession>
    <name>A0A1C1CC15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glucose sorbosone dehydrogenase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC15"/>
    <dbReference type="STRING" id="86049.A0A1C1CC15"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00439"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10358"/>
    <dbReference type="eggNOG" id="ENOG502R9MT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="507128at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051262">
        <property type="entry name" value="SMP-30/CGR1_Lactonase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572:SF4">
        <property type="entry name" value="LACTONASE DRP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572">
        <property type="entry name" value="LIPOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650705" evidence="1">
        <location>
            <begin position="22"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="2">
        <location>
            <begin position="37"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="477" mass="50058" checksum="07D52C775688244E" modified="2016-11-02" version="1">MRTFPSVIVAVLAASLSPAVAQSSSSCGPAPSGSIQPSLASGYRMQVVATGLSKPRGILLDKAGNLLVVEQGRGVVSAHTLEENDGCVSVGTSTDLTPALSLNHGIEISQDGTTLYASSSESVYSWTYDQSAMTVSNNATLVGNMAGSDHTTRTLLLSNKAPGMLVVTRGSTSNIDFDSASLDSGRSQIKAFNISNVTSTPYDFNSDGLRLGWGMRNDVGIAEHPNSGGLYSVENSADQITRMGVDVHEDNPAEELNFLGYLNGTQYASQGGNFGYPWCFSAWGVEDLPDNDNLTVGSQFAIDASPDSNNENRTDAYCAEQLPARLVFQAHMAPLDIKFNNSGTEAWVTFHGSWDRTDPVGYKMSVVAFNAAGEPVDELQSRTAARDIFANQDNSRCPGDCFRPVGMAIDSQGRIFVSSDASGEIYLVSRASGSPTSSGYPSSASSSAPGSNAAGSHVKPAVLSGIAGLFCAMALMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCN2</accession>
    <name>A0A1C1CCN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET9</fullName>
            <ecNumber evidence="12">2.1.1.372</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Histone-lysine N-methyltransferase set9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">SET domain protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CLCR_01086</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64456"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.372"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.372" evidence="12"/>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCN2"/>
    <dbReference type="STRING" id="86049.A0A1C1CCN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01086"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09280"/>
    <dbReference type="eggNOG" id="KOG2589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140943">
        <property type="term" value="F:histone H4K20 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10524">
        <property type="entry name" value="SET_Suv4-20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025783">
        <property type="entry name" value="Set9_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51567">
        <property type="entry name" value="SAM_MT43_SUVAR420_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="118"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="266"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="427"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="735"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT46241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="780" mass="86155" checksum="3A515699605D0A9F" modified="2016-11-02" version="1">MPRKNSAKEPDKAQRLSLAELAAHDDVCSDVMVDNAYYKSKIRKNRTKHIPIRGIKEEEIPKILLHKVIVDKDVKAAEKALLALPGLKRYKKSLRTKAEQEHFLEHLRKYIAMYQTDCAWEVSTTNRYTITTYEAAVTARRRIRQGDTIKYLTGTLVPLTTEESAELDMSNRNFSIVVSGRKKNSSIFLGPARFANHDCDANGRLVPHGENGMEVVAMKNIEVGDEITVSYGDDYFGPGNMDCLCHTCEQLERNGWTSKAAVLDTPSRTDTPLQTPFHEPLSASQPRGMKRKRDLDHSHSSSAPPPSKHAKALQSPSKLQQSWTPPDSSDSEVTQQAPRERRSEPVETLREAASKGSVALSPPHSQSRTEKSESPNPSQPGAESSAPVEAADLPANGVQQCPKSSTSHGNDHDGMMPARLLEKLSTNAPMSPAPTSPSSNGCSAEGLPPSQNMSHVQATDAPVTIKVESVETTKMEVDEDTIIVAPYRQISLPAADDQQLPSQQKQGISLSESSELTVPHALSTLATTTITKEIHEPSISAATENSVLPSIEPTSTSRTVAQLTVHPMTGTIRIAGDYILTRKLLAQPHDRWVQCHNQKCLGFFIQPNGYQTRRECPRCERHSMLYGFPWPKTDADPRKLLERKPTGKGKKAGTPAIEYSAYRRQGRSGKGTWVEGGGDPEERVMDHRTIHRFVLPEEEREQTRRGLLKEAEIARAAGDHQLAILEARMRAGSHSRALNGHGSESAARDVSESGSATPDELRRRSNRFVTRPVGVYTDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCT2</accession>
    <name>A0A1C1CCT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCT2"/>
    <dbReference type="STRING" id="86049.A0A1C1CCT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01326"/>
    <dbReference type="OrthoDB" id="5413892at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="183" mass="20081" checksum="89CB5843DD7DA71B" modified="2016-11-02" version="1">MADNPHPLGPQPNLVNLSQGLRTAADEAEKLQNLPAFRDSDAIVAAIQDLSQQFQNQFQNLNQQVQNQFQNLNQQFQNLNNQFQIFSQQLRSQLQASEINNVARIQNSHAATQLSPLTPLVNNLTAAQVPGFPATSRQIARMEGPELEAVIQELGVAPTAESVASKRRQLRGLVGLAAEPETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD70</accession>
    <name>A0A1C1CD70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD70"/>
    <dbReference type="STRING" id="86049.A0A1C1CD70"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02085"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01201"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="35"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="250" mass="27371" checksum="E1139D7AD4C79725" modified="2016-11-02" version="1">MKTYKSKEPDIDIPTDLNLTELLLSSARSPALPADHVIAQDHAENRTLTISQLRSNAGCLAAGLAQRYRPEDQSRWGIILPNSVAYLEAVHAVLWLGGVFCPINHQLKVGEIAHALTVSKPAFLIVYSEVVQQVMEAVKLACQGCPSFKPPELLTAIGPPVKGLRSLCADFMASKPLPVPHHADTRKRLASIHLSSGTTGNPKGVGLSQYNYVANVLQMWAHDPEHWSPEERVVSYTPFVHIANSEFEPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDD9</accession>
    <name>A0A1C1CDD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione hydrolase</fullName>
            <ecNumber evidence="3">2.3.2.2</ecNumber>
            <ecNumber evidence="3">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">GGT3</name>
        <name evidence="5" type="ORF">CLCR_01860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="3"/>
    <dbReference type="EC" id="3.4.19.13" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDD9"/>
    <dbReference type="STRING" id="86049.A0A1C1CDD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01860"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01200"/>
    <dbReference type="eggNOG" id="KOG2410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000008">
        <property type="entry name" value="Gamma-glutamyltranspeptidase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="425"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="477"/>
            <end position="478"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="597" mass="63672" checksum="DC3F74E51327814A" modified="2016-11-02" version="1">MASSLFNGAFPSLSAWATQAFGHFFIMLSLLQLACAFVVPPLLPQAGANPLPAVRQSDVPGTIGAVASESTICSEIGIDLLRQGGNAADALVGTVFCTGIVGSYHSGIGGGGFMIVRSSNGSYEVIDFRETAPAAAFQDMYNHNTNASIFGGLASGVPGEVRGLAHLHQNYGKLPWKRVMQGAIKTAREGWQVSEDLVRYMKSGMASAAVPNFLVDDPNWAIDFAPNGTLLGVGDTITRKRYADTLETIADKGPDVFYSGPIAEATIAAVQAANGTMTLEDLRNYTVAIRETANITYRGYRLFSCSAPSSGEVALSVLKILEQYPDLYHAGLLNLSTHRLDEAIRFGYGERTNLGDPSFVGNLSAYQDDMLSEATARYIRNKISDHSTLNVSAYDPNGIESLETPGTSHVVTADESGMAISLTTTINLLFGSQVLVPETGVIMNNEMNDFSIPGSSNAFGYVPSPSNYIRPGKRPLSSISPTIAEFANGTLYYVTGAAGGSRIITATIQSLVHVLDQNMTAPQALAQPRLHDQLIPNQVAFEYAYNNETVAFMKSRGHNVTWIAPGQSSAQSIRRLPNGTFEAAGEPRQKNSAGLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDW5</accession>
    <name>A0A1C1CDW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDW5"/>
    <dbReference type="STRING" id="86049.A0A1C1CDW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02180"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01383"/>
    <dbReference type="eggNOG" id="ENOG502QUVP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2141239at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="100" mass="10971" checksum="5DB3BF5E5DD41233" modified="2016-11-02" version="1">MGFGYALTNPDGGAAVPGAVKDDLKKRSPKPIIFCSATEWIDECTGWPAPEPVVKRDVAAAPVKKRDVEVKRSEKKAKRADIPFIPCSPTEWIDECTGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEC6</accession>
    <name>A0A1C1CEC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02114"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="156" mass="17348" checksum="458C06090154EFDE" modified="2016-11-02" version="1">MCYTQYVYEKCNLCCCVHEAIVQTRRCIHYEGSIDLDHTRIMNSDTATRAATAAATTSAHENPQSWRRNRPVVQQPVEVDDTVSDGQPRHHLCIYQSLLDLPTIAAAVHTCFSGALASNKTKFPSSTSASGPTTSPSLAPNHVPIVTMYPRRQRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEG4</accession>
    <name>A0A1C1CEG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT10</name>
        <name evidence="15" type="ORF">CLCR_02235</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEG4"/>
    <dbReference type="STRING" id="86049.A0A1C1CEG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02235"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02488"/>
    <dbReference type="eggNOG" id="KOG2036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="12">
        <location>
            <begin position="9"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="11">
        <location>
            <begin position="283"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="541"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="14">
        <location>
            <begin position="784"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1053"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1080"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1104"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="642"/>
            <end position="644"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="649"/>
            <end position="655"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="747"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT46930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1115" mass="124300" checksum="E234AE4AB596065B" modified="2016-11-02" version="1">MPRKAIDSRIPALIRNGIQERKRSFIVVVGDRAKDVIVHLHYIMASVDVKQNKSVLWAYKKDLLGFTSHRKKRETKIRKEVKRGIRDANTEDPFELFVTLHNIRYVYYKETDKILGNTYGMCILQDFEAITPNLLARTVETVEGGGLVLLLLKGMKSLKQLYTMSMDVHSRYRTEAHDDVVARFNERFILSLGVCESCLVVDDEMNVLPISGGKNVQPLPPPATEVDRVRPEQKELKEIKDSLADSKPVGPLVALSKTVDQAKALLTFVDAISEKTLRSTVTLTAARGRGKSAALGVAVAAAIAHGYSNIFITSPSPENLKTLFEFVVKGFDALEYMDHVDYTILQSTNPEYNKAIVRINVHRQHRQTIQYIQPQDAHVLGQAELVVIDEAAAIPLPLVRKLMGPYLVFMASTINGYEGTGRSLSLKLIQQLREQSRGAPSVNGDDVEVADKNTGKAAKDGQKVYSGGRSLREITLAEPIRYAPGDSVERWLNRLLCLDATLPKSKVNTQGTPHPSTCELVQVNRDTLFSFHPVSEKFLQQMMALYVASHYKNSPNDLQLMSDAPAHQLFVLIPPIPEDANKLPEPLCVIQVALEGRISKNSVLNSLSRGQRAGGDLIPWLVSQQFQDSEFAGLSGSRVVRIATNPEYLNMGYGSRALELLTHFYEGKFTSLSEKDEITIEDTEHSMMRITDTELESSTLLADDIKVRDIHSMPPLFSKLSERKPDQLDYIGVSYGLTQPLHKFWKRHAFAPVYLRQTPNELTGEHSCVMLRPLSSSTATDNSWLSAYALDFHRRFLTLLSYQFRTFASVQALSISESATRATKSTDGATSSTSPVQPLTKRDLDNLFSPFDLARLESYANNLLDYHVVLDLLPALAQLYFTGRLKAPPCNVALSGVQQSILLAIGLQRKDLSDVQQELNLPSNQLLAMFVKVMRKISTALRAVVGGDVEMNLRGNADNDGMPVPVPVPAPVSESHLQNTSGSRVTIKAPDLAEQQGIYEDEDDHDEEIDPAIKEKQRALIDALPLDRYQISATAAADDAAWDQAERQVREAGASTVVSVKSGREKVNKKRRLDDEGEDRDAKLNGDNVSRVEKRRDKKDKEKMGRRKAKTRQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF26</accession>
    <name>A0A1C1CF26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF26"/>
    <dbReference type="STRING" id="86049.A0A1C1CF26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02316"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02364"/>
    <dbReference type="OrthoDB" id="3210378at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="619"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="684" mass="74788" checksum="500297B2CB5735CA" modified="2016-11-02" version="1">MACPNLEALTGFYCFYNHTFDRLTHALSTRKHLRQHAWIVAENDDVTARGQTQLPPGLLDEDQSYQFVLYHDRWKRLETLLLCSPGGLGVIEHELFIRVLHSLPALKNLCISSFDTDDFHDLTLLSLPPWVTTLRLEECLGVTDTGLTRWAASPNAAQMERLSLLHQNITSLLTISKIFASLDRLIKFTIVQSDAVPSLPKEMRQLVVQPVLASKSLQFLHWDISRPKAGPTADPDDSEPERGQTTPNMHLALSVSHGGFPRLRRLRAPRDTSPLGILQSVCQPLYGHITLPGDASHSHHYRQLRRSGSLCAARLRARKIEVHQSNSTRTPASKAGNQLQAPSTDRGTLRPPAQNATSDSSTSTLGSWRTVGSNTSKRSSITNQTGPGPGPGPGPVSPLTASQDHFSPLAPDDGIISPIAADQDQVYLAGGDSDKQAVTGPQRSNHGESRKRHSICRCTPNPTGNRDSISAREGHEGSRQEKGAGVVPLPSRSPFRPIQTYAHSSTLTRFPSLTIRTPQRNRPVLYLRPDVPGLDSNGGLIGWGELLRISEKARKSTGSQRAREATQRNSKSSLDENSDDDDDDDDKAPTDMCTGFSTWHSRSEDGLGDLPMLRKIMSGSSAASGASSGRQGRSRSKSTSSSRLSFSLGVKTSDKDTMSNRRACRHVARPRGDRGGCVGLDDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF71</accession>
    <name>A0A1C1CF71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF71"/>
    <dbReference type="STRING" id="86049.A0A1C1CF71"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02227"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02266"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF46">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="279"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="728"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="937"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="974"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1199"/>
            <end position="1213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1338" mass="150421" checksum="89FF8213C590EDCB" modified="2016-11-02" version="1">MAKKKPSKASKKGASTSNINQKYWSNYSIDKLIQQCKSRQIAVPAQKLKRQEYVDKIEESLAKFGDKGPRDWNKLTVEDLKHECSLRNIDTTGLKKQGLLEKLDKGNATNGGKEPTGPRETTTQTSNDQQTQEISSANADKDYDNWDYRTRLLPAWKTLGIKSRKAVDIIQALKDRDKKESTQGRGSPEQPTGAPEPAPGTPEQPAGKETHPAAPRTSPGQAGGQHGTTAEGTLASPTSSTGSAFHRESAPPDPTRPVKTPMEALEAARSDIFSQSHGIGLSNPSHLCYRNVLFIMLLHCNRLLSWIEHRHIPNLEGAGFVLQIKQQQGDGGEDGRPYTDIWCEFLQLANVYWRGDGTNQSTVDQAMRRFWAYLTSDTRQLEVGEEPSNYTCPFKDETREHDVPQLFEWLVDLSVRQLDCYLTWWGYETTWREAILNRNVKEVMTVYQSVHNPCSQRRRVKHRKSKLEEGQMLRVEIPPARARSGQPNLTLVQCLEHSETFEMDPCSCAPISPRENIGDDTVEADQTPRRAWSKMWYTPEVLLVQLKRFKVRTAPNGGVRFDRHGNVIYEKDQSRIEIPEELDLAPFLEEKGQAGDLSTKYTLVGIVSHQGSRDGGHYITNVRRGDDWQEFDDNRVKKTSLKAVMDQKRRFTPYVLLYERIPEDTQRGAVDVNAHSNADGHEHDDSNGNARAGPSARGDGRARNTGNTRAHNAANRVAKASNRGNKLNRVASNNNGRGANRPAAREALQDQPSLFTSPYVQGMLGAVFDKLEKYFRKEIRDELVALQEAEEQYREANTQDVLMDYFVRREADMLATQQEQAGQINSLESYVATLEERHSELVSFVNHIDRAALTAFVRKRGHDQIHDGDGDLGNGWTPPSKRSKRNRGHTSSMDVVVDSEHDTAGMFTPDGLRDKMQHTRRVYGSNGRLQATHNEIQDADTELPDYVTSEEEEEEEEEEEEEEEEAEIVDETDSQSASMSISVSEHEDARASGDGTQDEEAAAPQAQLDAALLEKDHPASLPRDVEIDHALLMQECDVAKRAFADDYAAAHNIVRGQGPWSWMGPQHQQHFEAQLAEFLVDWQERAYDRIIRVADTPRSPRYVTETGPPAYSYSYSYSYPGPSAYEDSSRRPYITPAHTDDSPSRRFYSIGKTSRSHGKPNLDCDSKSRATPGARGHGQGLNTTSMGKASPTPDRRSSAKTTLKHSPQSARTLSRSRHHSRIPTPPLSPRFRPWRLLSPKPGAAAWEPATPEDQSTWYTPPPPRHRSPRGLSEREKSSLLRKGRSPGLGYGEPNETRWFGPQFGRSDLTRVNWPWAMREQALGGTTTAAGTVAADWWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF96</accession>
    <name>A0A1C1CF96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pon2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02302"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02282"/>
    <dbReference type="eggNOG" id="ENOG502QUCT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF12">
        <property type="entry name" value="PARAOXONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="418" mass="46084" checksum="A3E4EB7C12ACC82A" modified="2016-11-02" version="1">MAVNNWVWFGPLSLAVLLFSTFYAYPYPVLNTFLGRAHDAKVHTAWIHHGALKNERCWTNKLGKACEDVRIHHPSATAFLACGFPETRKVFYPPLNRHDTSSADTYHEYFLKYDIKTDTASKLKLEGIDSSYDLILHGIDMFEVKEEPDRIYLFAVNHGRKGESIVLFYHILGSDALTFVRDFSHPLIKTPNAVAATSLSSFFITNDHYYYGGGPIATLLRSHEDHWGPFKWASSVVHCSVKNPNPNPNSKTAALVAGDLDCKIVSPPDGHPSANGALLVDGGKTLLINDIVEATTTVYDVDPQTKMLSVRKKVQLGASADNLSEIPGTGDIAVAVFPDLAALRKRLGHPDDILDSSIKAEAAVLRLIKAKDYEPELLYWDDGSLITVLTAAAVDPKHGKMIAGGVVERHFMVCDIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFE4</accession>
    <name>A0A1C1CFE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ncs1</name>
        <name evidence="9" type="ORF">CLCR_02606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFE4"/>
    <dbReference type="STRING" id="86049.A0A1C1CFE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02606"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02247"/>
    <dbReference type="eggNOG" id="KOG0044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="190" mass="22007" checksum="4AEBA1839F0C9B1F" modified="2016-11-02" version="1">MGQKQSKLSPQQLEELQKSTHFDKKELQQWYKGFLKDCPSGTLTKEEFQKIYRQFFPFGDPNSFADYVFKVFDSDKSGTIDFKEFICALSVTSRGKMEDKLDWAFQLYDIDGDGKISYDEMLAIVEAIYKMVGSMVKLPEDEDTPEKRVRKIFRMMDKDENGSLDMAEFKEGSKRDETIVSALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFS5</accession>
    <name>A0A1C1CFS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02401"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02125"/>
    <dbReference type="eggNOG" id="ENOG502T5JZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3437607at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="522" mass="57098" checksum="71C63868FF02AF82" modified="2016-11-02" version="1">MIRLPATSISLSERDIDFHLRQAELYHGLRKQGFKKDDVVRYLRDYREAAAEAASQDKHGFDLSTPSTVELSSSRPRPASTSNGDLPLPSKRGPGHPSSTAPTSTSCIPFPDFASELSEPESDDGQLIYHKIQDVDDSRKVSPASMPSSINTNQHAPRKSSLLRFAQAASPERLSADTEDGTVGASVMNTAKAKKYRRRSTTYPYQSSERESAGEAYVDGQVLDRMNRMSLGEDDLHDELSSSSFALPPAYSDSVRTSSASDLQFASPMSGDGSGDSPSLSFVHAPVTHRRNSDQLERGYSIADVSSSPPLPVTPVREFTRRARASSDSSQVPTTPTPIRKASSVPRTEPKPYRQQLDGHSFSVYNDSLPASSQPETPADLSRQPLITEHEAAYTAPPAMIRSGHHGQHTWELDMGEQSPTARAMTLRGRRNRELTRSVRAEGVRLNRLMMRDEAMLTQRGLRAAAAANGDAVVAALPQIPDDVWRDNLDADRVGEENLEAELDVGGRRVMRAVSGNARFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGA5</accession>
    <name>A0A1C1CGA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Forkhead domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_03281</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGA5"/>
    <dbReference type="STRING" id="86049.A0A1C1CGA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03281"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01885"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045178">
        <property type="entry name" value="Fhl1/FHA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712:SF29">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="394"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="665"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="665"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="452"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="744"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="978"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="770"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="812"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="884"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="990"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1016"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1064"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT47497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1076" mass="116424" checksum="4EB08237EE0AC6AF" modified="2016-11-02" version="1">MSSQAIATSTRGLPDFTSWPDHSNLHRDNHSDSDREDEVDRQPSHSPVSSRPSWSEMDVQQRSQAVGNLLAALAPISPTSTPTQPQTAPAPAHAQTHPPPLPDLPIEPLDDVEGNPTAGATDGNNQNLDPNIADASLPTLPLDYPDHFLDASTLPPLPYPLPLDALEESLPTSSGMAAPYREESPPSAALQMSSPEKRERRQVEAFAKLEFDDGNYYITTYACELGRDAFAYKAALAREEALKAGHDRGHSSSGRSGRRSGLSQGVPLPGDSQVQGSVVSEAGGFGGVDDGPILKHGKDEDGNPLHSHSSEMSAGSVVRPQEVLYHPPPAPFDYHRTAQRQADAENKKKVRDPEEEKPAPVTDEHLPDANRCPLIPIHATQNEEISEVACHRNISRRHVRIEWSDKKECFQMHILGRNGAFLEGEWLACGQVRKLRDGSKIQVSGVEMTFRLPLEEKEESPSEESGREDVDQSPLPPPRSTSPTSDEQDRSISPPRPAPGKGKTKIILKASVQPTAPPPPPAALPEPLLGPDGLPLPAKRRGPGRPPKDGIMSTRERKEREKAAKLAEAKAANGGMTPPPMRGNKPQKPVMKEEEPATDLKPEKRKYKKRKREGEDGDVMPSIEGGEIEMTAEPEKPPPPKKARSKSPSPDYPPAESLTEEQLARPSEPYARLIYDILLDIHPRALPLKQIYRALKLKFPFFVHRVDSEGWQSSVRHNLNQEWNKLFEKGEKEGKGFAWKAIPGALQPQAERRRATQQASASKPKPMPTPRQTVPQGPPQQLNWQNSTPYPHNGMPPQGHHPPFYSQGPNGSLPPPPNGMPWPAPGSLPPSGSPYPHGKAPPYGQPGQHAQPFYPTQQGPSHGSVGHPANQGPYRPPHTGATPVPSSVIPTSTAASRNMPCTLDGLITIKTFENAMLKTVHPSDLERWQRIFASARNRLLHGHPESMMPGGESAEEATIMKHMQDFIQRFRNPSFVGFSIGTGSPAPNPVTATSKTSTPQPIPSASAVKSTSQNDPSAQAVASPPSPPHSASNAPANEPSKTPVQKPEAAPLAGSDKMGGVEPSTTATSAATDSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGF0</accession>
    <name>A0A1C1CGF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BHLH family transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_03727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGF0"/>
    <dbReference type="STRING" id="86049.A0A1C1CGF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03727"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01863"/>
    <dbReference type="eggNOG" id="KOG3582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="165" mass="18427" checksum="D9EA40C52AE3598F" modified="2016-11-02" version="1">MSNQNASESGGSSSASSPTSETRPQMVSKSSSSKKANRVSKPRLTASQKNINHKDAENKRRTAIRERFTELSNLVPGALGHERSEQVMLGKSTDYLREMLLEQRRLEEMAQKQGITIDSGEPIREDDFGGPKWKANNMKQYEASKQKKDGDESHQANDQGDEEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGH5</accession>
    <name>A0A1C1CGH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGH5"/>
    <dbReference type="STRING" id="86049.A0A1C1CGH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03553"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01819"/>
    <dbReference type="OrthoDB" id="4153569at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="413" mass="45844" checksum="48E185D737CB7A4B" modified="2016-11-02" version="1">MNEAEKLHSTNPKFTHCGGLDDDAASSLLPDSFETCQVPEFDETDAPNFVSFFIFVIRTKGREMAPLKPAERLNFFLQLQHPLRDALLDKYQDSRLQGFQNLREPKTALDQLMARVLTFNNPTEVVFQMSPTALPFFFIDELSNTRILLNVNRATPFGHLLAILREASADLATQIKNNAHFPNGGTRDRPSATHFTWDDGPYLARVVTVMQGPGGQARVSRTEWKTVYGKTYLELFNGPHARKIGSSVEIQHTLQHFRNLSAFRRGSPPPSGLRRVAETASNGIHFSTPGQGHHNFTHQHPAPHPQRSHSRLLPFVDEPSRTPIPPLLAPPSPPPPPPPPSPVAGRPVVRLPPVSTSVVAPLRVVPVSSTSRAGVLVVDGGDLAWYKREGELREWLRFGSAEAVESVDVWSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGK3</accession>
    <name>A0A1C1CGK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03763"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="114" mass="13140" checksum="9A1B7030A7057851" modified="2016-11-02" version="1">MSRSVVYTVLRTIERNALELKTKSEAFMRYQYTLDPRAEWERRCQATAQMLAVEALQPILSLAVTFMRNRDSTAGATNRETPQSRVLVVWYSVCPAPYDIDEGQRIHVAVIFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH55</accession>
    <name>A0A1C1CH55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ERV1</name>
        <name evidence="11" type="ORF">CLCR_03695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH55"/>
    <dbReference type="STRING" id="86049.A0A1C1CH55"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03695"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04499"/>
    <dbReference type="eggNOG" id="KOG3355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160203">
        <property type="term" value="P:mitochondrial disulfide relay system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="77"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT47854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="189" mass="20846" checksum="537973A25C22A4E2" modified="2016-11-02" version="1">MSFPFPSGKASGSQESRSSNEDTPQQKVARGVVLDKDGKPCRTCTSSAAWLAMMKSSGKKPKAAAAAAAPVAPRSDCPPDVEELGRSTWTLLHSMAATYPEVAPPETQSIMKQFISTFSRLYPCYVCAEDFQDWLIQPGNEPKVKGQDELGMWACRAHNAVNVKLGKPEFDCNLWKERWKDGWKDGRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH77</accession>
    <name>A0A1C1CH77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative aspartic-type endopeptidase OPSB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">OPSB</name>
        <name evidence="12" type="ORF">CLCR_03428</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH77"/>
    <dbReference type="STRING" id="86049.A0A1C1CH77"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03428"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04545"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650818" evidence="10">
        <location>
            <begin position="22"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="11">
        <location>
            <begin position="56"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="90"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT47801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="520" mass="53698" checksum="C6E6B892B591F6B8" modified="2016-11-02" version="1">MKLSSMHLVLAAGYMTRCAEALGTFKLDFTKERRAVTHLGKRGRPFEVPLVESSLYLINVTVGIPPQTISLNVDTGSSNTWFPSVDSNPCQAANGSCVDGVAFDPNESSSLRYLSNGSFAVAYGTGQATGDYISDSVKIGPATINNLTLGLAANLSAPFANGLLGMGYDSLETLAASSGIQFPGVLTRLKQAGVIARRAFSVYLDDQEAGVGSILFGGIDTSKYTGDLVAVAITPNGTGVYDRYRVDLTAVSFLDSAGKSTLLSPANMSAPCAVDTGASYNILPASVSQALVEGLGAVSYAGVYFVDCALRDSNTSVLFQFGGPGGPIIRVPISEMLGVPLGFTFNDGRNGCQLYVGQVDDAELQSLLLAGFTIGDPVIRSAYVVYDVDNNEIYLAQAAFNRTGKGKVQEIAAGSGLPGVTSTATATASSFPTAFPPSILSEISVSLVSNQTASSPGLTATTQLPTTPTSPSFDIAAITGSAATTTSTSSAAASRSFDAGIDTIAGAIVLLFMPWITLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHA8</accession>
    <name>A0A1C1CHA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHA8"/>
    <dbReference type="STRING" id="86049.A0A1C1CHA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03543"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04439"/>
    <dbReference type="eggNOG" id="KOG2865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000358">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 39 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="382" mass="43852" checksum="02046BF86C0F3FC8" modified="2016-11-02" version="1">MQTCQATLALRTARSSLRPKPIALQRRSYTVQDIAITRTGKPIIKHRGGRSSLGGHTVTVFGAYGFLGRYIVQRLARRGCQVVVPYRDDMAKRHLKLTGDLGRVSFMEFDLRNTQSIEESVRHSDIVFNLIGKNYPTKNFSLWDVNVEGTERIAEAVAKYDVDRFIQMSSYNADENSPSEFFRTKAYGEKVARQLFPETTIVRPAPVFGFEDSLLHRLAGVTNLLTVNNMQERFNPVHAIDIGMALERIGYDDTTAGETFELYGPTNYSMREIAELVDKEILKERRHINVPKALLKPILYYLNKVIWWPIMTADQLEQESIDQTIEKGAKTFKDLDIEPAELRDLTYHYLQDYRSSSYYDLPPATAREKQQAKKFLHVIDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHG3</accession>
    <name>A0A1C1CHG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHG3"/>
    <dbReference type="STRING" id="86049.A0A1C1CHG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11274"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04448"/>
    <dbReference type="eggNOG" id="ENOG502SQG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5315820at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="311" mass="31844" checksum="3DDD10D47EB16828" modified="2016-11-02" version="1">MPNRGPTLINLPPPPSDPATPSEMGPGTPNSTTTSLSALSVVAIKDGAMGHGGRGATASANTLEAERADRISRLAGLERVATSRPTPLGHLVPGAGGIYGQAFDNAPQFRERSTVGSASATGSVGGRTTWASGSIDYDVDKMSEDPDDGVSSTGGFSDEDKASLVGFGEGAGSTVSGPVSTPYNTRASISRTSTNVVAPSTPRTGNIPAFGFGSGQSTPMSGITPSAAAGSTDPKMMDGMSYDQNIIDTTMQPAPPVDEPPAYGQPTRFSGMGTEMAEQVMRDRLGGLEQAQQSMHQGDGQSLGRFPFEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHT4</accession>
    <name>A0A1C1CHT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04473"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="82" mass="9188" checksum="118ED0C23FEFDFD3" modified="2016-11-02" version="1">MADMARGMVPVKISTSSDFMASSPRYRGMLWRTDSSVHQTQHCGYVYVYGPCSCPHYTVRKESLDMIDAPLGTTPEGDQPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI08</accession>
    <name>A0A1C1CI08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_04349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI08"/>
    <dbReference type="STRING" id="86049.A0A1C1CI08"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04349"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08289"/>
    <dbReference type="eggNOG" id="KOG3282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000002">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT48138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="227" mass="24104" checksum="F21B7C1818CED20C" modified="2016-11-02" version="1">MAEKAPPSLTAVAVSSLLLGLLAGYFLGQGSSIGVFGGSGTSKQAKKSWPNSYDVKVHADSSDDQADDEDEADEEDEDGDGKELKDFKDSNEDVKLVLAVRTDLGMGKGEEELTRQRNLLANPSLAGKIAAQCSHATLACYKYLLNHVTSAPMLKRWERGGQPKIAVQVKSEEEMETLQAQAISLGLCARIIHDAGRTQIAAGSATVLGILGPKSVVDQVTGHLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIF4</accession>
    <name>A0A1C1CIF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PBSP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIF4"/>
    <dbReference type="STRING" id="86049.A0A1C1CIF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04314"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08378"/>
    <dbReference type="eggNOG" id="ENOG502QURC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="891726at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="241" mass="27239" checksum="E4259FDEF07EA392" modified="2016-11-02" version="1">MAPVIPPQLRHKPVLRLHIDDISHPAAQVASSSLDGGLYLVRAIEHVVAWLYRPYGPDDIPRVRSVTVVLRSMGGVAYTTGLPLDDLHKEIHLSLDYVQGVLSRNSAGLRHELAGVITHEMVHCFQGNCEGTAPGGLVEGVADFVRLKAGLSPPHWNRAPENRGHKWDEGYQKTAWFLEWLEEKRGAGTVSYMNEMMRRHRYHEDKFWKGIFGLSVDDLWSQYKESWEKPKQNIAGSIEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ28</accession>
    <name>A0A1C1CJ28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chanoclavine-I dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_04302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ28"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ28"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04302"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08591"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="248" mass="25686" checksum="F4E8B3E239DCC76E" modified="2016-11-02" version="1">MAQLQDKVIAITGAASGIGAATARLAAARGASGLALSDINEQALTKVVDELKAKGTKVTGTRLDVSDSAQVDAWIAATVKEFGRLDGAANIAGVEGPPGGKVFQNLVDISNEHWDYIMRINLTGVFYCLRAQLRVMERGASVLNVASLAGVMGRPGIGAYSTSKHGVVGLSRTAAKEVGERGIRVNALAPLLNDGDATDRPVTNTYKTLPLQRLGTADDMAKTICFVLSDDSSYTTGATFSADGGVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ58</accession>
    <name>A0A1C1CJ58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ58"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04456"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10293"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="81" mass="9273" checksum="6C566F4117B08289" modified="2016-11-02" version="1">MSCTTCSSCEAFENTSDKPKLSTARNKANLEKGRQTLHSAYTGQQSITEKEEIQQYRDLIRWAEEDHLEDLKATLQHILDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJI7</accession>
    <name>A0A1C1CJI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJI7"/>
    <dbReference type="STRING" id="86049.A0A1C1CJI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05286"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03219"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="96" mass="10518" checksum="F2DC218CB363C159" modified="2016-11-02" version="1">MDSLLVQLIERAEALAKNWGIFRLILLGSFGLCVVAMVGLYQLLKPIDKRRSPTGKKWKLPPGPRGWPIVGDLFLYAKGEEGVRDTLEGSSGQGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJK0</accession>
    <name>A0A1C1CJK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05275"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="110" mass="12403" checksum="2A5BFF79E48F0CC3" modified="2016-11-02" version="1">MPPPSRPLSSHLPTRLLQNLASVTSFSLQRPYPVLWYPDDLVPRVCLQILSKRSVDDQMVKTELAALWSVRVPKAFIQEMPSCAERCYISHAKSASETAGKWLHALQIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJL5</accession>
    <name>A0A1C1CJL5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II transcription factor SIII subunit A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJL5"/>
    <dbReference type="STRING" id="86049.A0A1C1CJL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04846"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03256"/>
    <dbReference type="eggNOG" id="KOG2821">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="50231" checksum="3955869CCB5F533F" modified="2016-11-02" version="1">MPADSLLDMARRVAGRNVHKITDIGDVSYNIIRPVLLKIESPEQLYQLELNSPQLVGNTSELWLNFMKRDIPDYELKPHIPTNPMSWYKVYKKLKKEASKAASDAEAVLKATLSGIKSLKEENTAEVVSTERGNALYSSANAPGPSRRGRIMYNYMSGRTGSKGANKMTLMEKIRKEAKSAKTGVMGRPMHELQKKHNGVVSAPAQFVEDVKRMKVLQQVEARKALTPPPKRSLSTTAMGAGASARTSTPPMHAPGSRPPKPRPHPAAANGLEPYDLTSDREARLRALKAGKPIPPKPTVPDSALPPSPTLLAPTMQSTSDANGTLTLDFLESDSDHEPAQDTHKPGKTRQREADDALFGRSTTPSVKRKRDAEDDSGLPRKVLRPVSDDDVSPPPQKLSRHRSGEEVSPSRNLLKPTILDADLLARSRSPLKLSPASSPRMQPVKKRQAASLFMKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJM0</accession>
    <name>A0A1C1CJM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJM0"/>
    <dbReference type="STRING" id="86049.A0A1C1CJM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04576"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03176"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03177"/>
    <dbReference type="eggNOG" id="ENOG502QT5Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053931">
        <property type="entry name" value="RapZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43812">
        <property type="entry name" value="BLR2425 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43812:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22740">
        <property type="entry name" value="PapZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="318"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="565" mass="63238" checksum="0A31B10CAD66F685" modified="2016-11-02" version="1">MDPLLLSIISFGRANGPLNPIGSEAVEQLRFSVRDVENPPARLRKTHTGVSARLRKEIFGNQAARRRLDTMLQVVEAKMIEFSKAHIQAEHTVEGLRSLLPVCPTLLIGIMCEQGKHRSVAFAEELGRKITPRDGWTVSVEHRDLGVFLTNAENEDFDERTANTKALRRSKRQREQERKQGRSFAGEGFEDDTFGDEEMQPNMPQDKTERYRFLRDLLGASTVEIYNFQSYVSVRVSSHSHQAGLSTLQDFGIQVKHYCYKYLVAQTQEISKEAYIIYTVEIEPNIQSTTYQSHAPPPTMFYEPGKTDHNLPHDPFKACVIPRPIGWISTINPQSESNTQPTNSTNKGNSNDIDNSIGQANLAPFSQFNNLTFDPPYIMFSSNQTPSRQQKDTVRNIEATGVFCWQLATYALREAVNVTAEQVPYGVDEFERAGLEKEYSTVLATAVPMVKASPIKFECEYYTTLRLPGNPPMGSADVVVGKVVGIHIDEGVLTDDGKIDVTKTQPIARCGYYDYAVVKETFQMIVPGGTTDTLYGLEGNVRKHNAAREAGRRMGVSAEDEQGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJR3</accession>
    <name>A0A1C1CJR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">GCDH</name>
        <name evidence="18" type="ORF">CLCR_04913</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJR3"/>
    <dbReference type="STRING" id="86049.A0A1C1CJR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04913"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03144"/>
    <dbReference type="eggNOG" id="KOG0138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="17">
        <location>
            <begin position="46"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="16">
        <location>
            <begin position="161"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="15">
        <location>
            <begin position="276"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT48758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="426" mass="47017" checksum="0BD238A98A408C6D" modified="2016-11-02" version="1">MLSRHLLSRAARARSNLAARTASRRHASSAATFRWEDPLNLSNFLTEEEQAIQETAHSYCQERLLPRVLEAYRKEDYDKKILEEMGELGLLGATIKGYGCAGVSNVAAGLITREVERVDSGYRSGMSVQSSLVMGPIDEFGTQEQKDKFLEKLARGQLVGCFGLTEPNHGSDPGSMETTAKPHPSKEGYFSLSGAKTWITNSPIADVLLVWAKLQETGKIRGFLVEREKCPPGTLETPPLKDKNGLRASITGMIQLDECPVPKENMFPEVEGLKGPFSCLNSARYGIAWGTMGALEDCIQRAREYALERKQFKNNPIAKYQLVQKKLADATTDAAFGLAAAYQVGRLKDEGKVTPEMISMIKRQNCDRALVNARHLQEIFGGNAVSDEYHIGRHVSNLFVTQTYEGQSDIHALILGRAITGLQAFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL40</accession>
    <name>A0A1C1CL40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cka</name>
        <name evidence="12" type="ORF">CLCR_04943</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL40"/>
    <dbReference type="STRING" id="86049.A0A1C1CL40"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04943"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02699"/>
    <dbReference type="eggNOG" id="KOG0668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT49238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="335" mass="39292" checksum="6AC41F97F6540B65" modified="2016-11-02" version="1">MARVYADVNANMPRSYWDYDSVAISWGVLENYEIVRKIGRGKYSEVFEGINIVNYQKCVIKVLKPVKKKKIKREIKILQNLSGGPNIVALLDVVRDSQSKTPSLIFENVDNTDFRTLYPRFVDYDVRYYIFELLKALDFCHSKGIMHRDVKPHNVMIDHAKRKLRLIDWGLAEFYHSGTEYNVRVASRYFKGPELLVDYQEYDYSLDMWSLGAMFASMIFRKEPFFHGNSNSDQLVKIAKVLGTDDLFEYLDRYDIELDAQYDDILSRFPKKPWQSFVNADNQRFVSPEAIDFLDKLLRYDHQERLTAQEAMAHPYFAPVRTQAAQQQNSQNHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL69</accession>
    <name>A0A1C1CL69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_04622</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL69"/>
    <dbReference type="STRING" id="86049.A0A1C1CL69"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04622"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02740"/>
    <dbReference type="eggNOG" id="KOG1827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6017at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054551">
        <property type="entry name" value="RSC4_Ig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22994">
        <property type="entry name" value="RSC4_Ig_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="63"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="233"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="326"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT49192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="640" mass="72190" checksum="BA4EBDDE7E02DDDB" modified="2016-11-02" version="1">MSSKRRSGPAGLDPDDFLATPGPDLKRRKRSDDTHFPDLETRETTTDIGLKLVGQLKRSQDKNGRNVAVHFLDLPSRTEYPDYYQRTAMPLSLNIIEQRLQNFEYENLERLESDLKRMVQNAKDYNNSKSSIFEDAERIRKALSNFMPKHNPAYLREDYRAYPTPIPQELYDQIRQQSISSEGTGVPEKVKLRFSNPAAVRRQSQVPSMVGTPAINAGEDVKEEQLAFLQELSEQEDAINFEEKVPKKDYPDYYKMIKKPTSISDLRALVEKGVVQDWDALAKEVRLIWDNAKEYNLEGSDIYLMAEKLEAWSDSKLQSLGAQPRRNLRLSLSQPKPKALRLTMGPSTPTPHVVGGTIDSESLRRQKREMGEALNRAQRATSKTTQVNGSTPGPSSAAPSVRRSMSLATDQADVVMADIKTNGTSGTPQAEEAMKTPQAPAQQLPTPVQEFETPLPGDAPLTNGITLHAPHPQSSPPKGSTNTAFNYLNQSVVPMERRFRDPGRGWDFALFSSVTFMTNPSLPNDPRWKLIRHGSPIKTQTSGFIALPPAYRDIRIIPELTSELHSRRRHRVFFMHNATVYKESNSVHVPGAFEVRLVPGENVLVVEVLADLREGERKEYAPSQLQFDFERCTMIVHLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLH9</accession>
    <name>A0A1C1CLH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLH9"/>
    <dbReference type="STRING" id="86049.A0A1C1CLH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05243"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03275"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="2">
        <location>
            <begin position="42"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="121" mass="13554" checksum="87FCF59159C3521E" modified="2016-11-02" version="1">MALSDTRNYVHAVESDKQEAARIAESTAQKLETRQTTLIELVQSLGEYINDDDDRIRARAVSYLVAVIAALPPKYLTRQQIQVLCQFLCDRIEDGGAIEGLSKLQSLDRFTPEMAQTVVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLW7</accession>
    <name>A0A1C1CLW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ran GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rna1</name>
        <name evidence="5" type="ORF">CLCR_04920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLW7"/>
    <dbReference type="STRING" id="86049.A0A1C1CLW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04920"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03355"/>
    <dbReference type="eggNOG" id="KOG1909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006404">
        <property type="term" value="P:RNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT49442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="421" mass="45557" checksum="FAC07E584B438A1B" modified="2016-11-02" version="1">MANSSSTFSLAGKGLKIDTKEDLEKHIEPLTSSSTKTTHIDLSGNTLGVSACAALAPILSSQSALESADLHDIFTSRLLEEIPPALDSLLTALLDCPNLHTVDLSDNAFGLNTKDPLVDFLSKHTPLKHLILNNNGMGPIAGTAIAEALCKLAERKEAARKEGKDVPYLESIVCGRNRLENGSMAAWAKAYEAHKVGMKSVKMTQNGIRPEGISHLITSGLSKCENLEVFDLQDNTFTIKGAQALARAVHGWSSLKELGVGDDLLGARGSIKVFEALASGNNKDVQVLRLAFNDITPAGVKALLQAAKDGLPKLRRIELNGNKFEEDDESIEALAALLSERKDENAKDDDPDDHWGLDELDELEGEDEDEEEDEAEEEEEEEEEVRESVLKDADQAENATVSQKKDADVDDLASALEKTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM42</accession>
    <name>A0A1C1CM42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_11338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM42"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11338"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09833"/>
    <dbReference type="eggNOG" id="ENOG502SJRB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="501" mass="56283" checksum="6797A5476BD6DF71" modified="2016-11-02" version="1">MASDDDSQALDTHHDDKDWEEQKENFRVCYIDRNMTRKEAAEYMKQHHNFNATPRQWERKIKQWGFSKYTGRDERLAQIAQSGKTVLDVSRPGRRPRSLVDERGNLQPHEDRNLRRFARREVSRSRSRSRSASFADRPRPQFKQEFSDPSVASSLDPAFSFNDLSSEMRRTPSREGLITSRMQGSREMSEPLQPNFFQNQQAVAYEPRDDPSIAVGMPSQYQQGHPHGSPPFNTVPAQTQFSTFVHGPIPLHASHGMGLANSNQTFSGNSTDSSFGYPMQEPIMQPIPTGFNQFGMHPSMLPEGIMTEQGIFDSGLTLQQGPDALDQAGFENHPMITFDIVDTDTPAMMPASEPTPLQNQPPTSASFPETPLSDSGSLGRDVLPLVEQYIRAVQNVALNALPRSTHAEDFSEKLAADLVQPSSAFMASMAIFLDNFDKTKQRSLQSMKDTCSKLRQKNAMLEQVLNGHSEMQPVPSIETQHHRSSVPPQASMYAGMYGPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM90</accession>
    <name>A0A1C1CM90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM90"/>
    <dbReference type="STRING" id="86049.A0A1C1CM90"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07371"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09866"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="108"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="348" mass="37594" checksum="8C95B5FA95DFFDF9" modified="2016-11-02" version="1">MATSFALDADFEACLKANGLEEFVGGPPFPSGDVDQRRKRLKNLSARRPPPTIDTSGVDVSDHYTVSEDGHRVLLRWYCPRSAAVNGSHTATLTTTTTTTTVTTKPAVIYIHGGGLICSTIDDYNVLVTSLVSMTRTPFLAVEYRLAPEHRYPAALHDVYAALAWLHARAHDLHVDQTRIAIMGSSAGAGLGAATAILARRRGGGLSIAKQIFTAPMIDCRNVRPHDPRLAPLLSWNHLDNATGWSSYLGDEVLDGHEEGDGIPDTASPSRLVSAEGMPPLYLEVGSLDIFVQEGIEYASKHVRAGVPVELHVYPGLPHSYDSLGGQCQLARMAKAHRVRAITCLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMA9</accession>
    <name>A0A1C1CMA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMA9"/>
    <dbReference type="STRING" id="86049.A0A1C1CMA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07843"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09888"/>
    <dbReference type="OrthoDB" id="4113643at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="77" mass="8608" checksum="0D95AF93D1FE4AC5" modified="2016-11-02" version="1">MSISLYEKRRFNKFVNVLFTIIIVTLVMGPVMVLYRLRDSNGYVRNAAAVIFTASFALLCSTATNAKRQEVFAITAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMU3</accession>
    <name>A0A1C1CMU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gst2</name>
        <name evidence="8" type="ORF">CLCR_07572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the oxidative stress response and detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMU3"/>
    <dbReference type="STRING" id="86049.A0A1C1CMU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07572"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08768"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000016">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="94"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="213" mass="24237" checksum="6DE61FF5FA642F14" modified="2016-11-02" version="1">MSNSSLKPITFYAHGPTPNPRKVQIILEELGLPYTVKDVDNSELKQPPFTNINPNGRLPAIEDPNTGISLWESGAIIQYLIETYDKNETLTYTSIPEKYQLNQWLMFQMSGQGPYFGQAAWFKNYHPEKVPSAVERYVREVERVIGVLDGWLQQHKFLVGDKLTYADLAFVPWCAGVPWLDSDKTIDMAKYPAYSKWLGDMLARDSVKKVTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNP9</accession>
    <name>A0A1C1CNP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07808"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09003"/>
    <dbReference type="OrthoDB" id="4156248at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="91" mass="9553" checksum="A09D243FE82333E9" modified="2016-11-02" version="1">MSTPTHSFLTLIPATHRVATMSPFTSPIEGPAVDESLVPALQKTRRSSSTTSTGCASSVEDPTLASDMVESPVEGVKSPEVVAHKFLKLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP32</accession>
    <name>A0A1C1CP32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aryl-alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xylB</name>
        <name evidence="8" type="ORF">CLCR_07189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP32"/>
    <dbReference type="STRING" id="86049.A0A1C1CP32"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07189"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05749"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08278">
        <property type="entry name" value="benzyl_alcohol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF2">
        <property type="entry name" value="GROES-LIKE ZINC-BINDING ALCOHOL DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="16"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="386" mass="41227" checksum="E671D16606265E31" modified="2016-11-02" version="1">MGPYKALVARGPAREGQWRLETVTARALREDELLIRIVATGICLADLHLGDVAQGAGGHPRIYYPRVLGHEGSGYVDEIGSAVKGFQLGDAVLLSFNSCGHCYSCQENKPALCIHSDELNFGGDEGVYATEGSTDFKIGGSFFGQSSFASHAVVKERSAVNLQGLIDSDEDLKLLAPLGCGVQTGTGAIINTANVQAGQDVAVLGVGGVGQSAIMAARIRGCQRIIAIDRVPARLRLAQSVGATHVIDSSMEDDLVAAVLRITKGAGVHVSLDTTGVSALARESYRFVRHGGKILQVGLAQQEDKWDISMPVHMNSGKQIIGCVQGDAVPQEYIAKMIAWFKAGELPLQQLVTFYEVSNFQQAIEDMRNGRTTKPVLVWPEVVGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPB4</accession>
    <name>A0A1C1CPB4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07697"/>
    <dbReference type="OrthoDB" id="10666156at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="165" mass="18366" checksum="97219EF937FB73D3" modified="2016-11-02" version="1">MSWKLAELRWRHVVGLNERRRERDQESGEEGQMGSPGSGGRIQMKHVRSYSAPWCRVVEDSSPSDLSACNAIRSDPRSLALSPGPSVSSTTPLLKRTQSRTNPIADHCCALPLGDQHEKESEPFLSHLQAPLQPNSFLDKHILNPQFDGVQETVLPQEGMSSYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPN9</accession>
    <name>A0A1C1CPN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPN9"/>
    <dbReference type="STRING" id="86049.A0A1C1CPN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06923"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05572"/>
    <dbReference type="eggNOG" id="ENOG502S317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4174342at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="573" mass="62579" checksum="D2A6461203A86C5B" modified="2016-11-02" version="1">MAYNTSYLSSPDTPSTVFPERLIRPLPKRSIKSRLSQEAVEAIQYPPTLPSSSLATYSNYGENGEETHDGKVLDHPHSDNYYHDHDHDHDHDHDDDDDDCPHHHHHHHHHHHCHHDEYEDDLDSQDERIYPPRRFIVSSPRSPRSGRSRYSTRGSTSGPDGYEAFENTNNKKKRKIPTSGSLSLHQSAVTDQLAHMGISGTKDGTADDGFYAGAHAGNSAGLGVQGAGRGRGARKVSGRNPLGVSVNGSNARNGPSKYDQNMTANAKGKIERPSARATEADFGQAEETKDQGIISAAIANATALLRKPLGKGQEHVGVLDQEANQAHNNSQFTFTCEADAKGVTFPEQSLYSPGYTQRNNPTHPAHSTATEKGTIQASQSTANATAPAVQTAPAAPAAQNVNAQGKKPRRRRGDVYALAARQRKLQQEYNNLQHPPAPEDIWICEFCEYESIFGQPPHALIRQYEIKDRKERRRLAEKRRLLEKAKLKGRKGKKQTKNAAKAATHNAGNVNQQAYDNQPLDQLADDDLDYGYDDDPIPMPAPPPATTANKTVAGTRTASTDKAGGTAGGGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQP4</accession>
    <name>A0A1C1CQP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQP4"/>
    <dbReference type="STRING" id="86049.A0A1C1CQP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09105"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09476"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19890" checksum="5DB4E5644BE5E56C" modified="2016-11-02" version="1">MASEDHQISPERNGDDEKYMGEKQETPYVDLHESATAKIKNPLAHLSNDEVIKDVQEFARVNDFSDHTDLLIKGALVAKDPPAFESVPGLTEGEKEAIRNEVLHKWRQPKSLYFTIILCSIGAAVQGWDQTGSNGANLSFPDALGVPVSDQLADGSPNPNAARNQWYQGLVNAGPYIASAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQR0</accession>
    <name>A0A1C1CQR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_08445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQR0"/>
    <dbReference type="STRING" id="86049.A0A1C1CQR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08445"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09493"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000065">
        <property type="entry name" value="Similar to histidine acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF12">
        <property type="entry name" value="HISTIDINE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650974" evidence="4">
        <location>
            <begin position="17"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="64"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="410"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT50847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="445" mass="49046" checksum="76BBBA5D40713DDD" modified="2016-11-02" version="1">MALLACLLYLASYVAALPVYPAQSPILLDHTQGYKFDPLLHLPGISPYFDAVGFGLEHAAPPGCTVTAASYLVRHAAIYANDDEYEEYIKPFLWKLEKHRQGWSGPLEFMSTWVSPILEDHLEDITPSGAEDAQKVGSHLVKRYPTLAPTVKKILADKKPRTFDTAVALSKAFPNHKDIEVVQFLHNHNGSFDSLIPHKSCSAFSKAPGTKEMATFVHHYAPHVSGRLARFTPFELSDNDVVGLQSLCGYESAIKGEQSPICAVILTSSGDLKYSHMVGPLNPLSPYLGFPWLKTQSELFQQLNGEPNSGSATDTGSGWPSSQRFFLSFTHREVPPFVATALGIFNSSSSAMEEFPTDHINWARSWRMSDLIPFLGHVGMEKMTCDGRPGREGEYIRVIANTAPRPIPSCQDGPGASCSMEQWTDIIAQGAEKYKDYDEICSNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR20</accession>
    <name>A0A1C1CR20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08846</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR20"/>
    <dbReference type="STRING" id="86049.A0A1C1CR20"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08846"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09555"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="334" mass="36958" checksum="18BB332D62C1E6A5" modified="2016-11-02" version="1">MRVLLTGGSGFIAAHCVDYLLQHGHSVVFTVRSEEKGQKILQNHPDQAKSKLSYVIVGDIAKEDAFDEAVKSDPPFEGVLHTASPFHFNVTDPKKDLLDPAIIGTTGILKAVKKYAPTVKRIVITSSFAAILNASKHEKVYSEKNWNPITEEEAIQNPANAYRASKTFAERAAWEFVEKEKPNFDIATINPPLVLGPVVHYLNSLDSINTSNERVRNMIQGRTKESGLPPTGVFIWVDVRDVALAHVKALEVPEAGGKRFFVTAGHYSNAEIAEIIKNEFPDLADKLPAEIKSDKPADVYEVDNSRSKQVLRLKYRTLEESVKDTVKSLLEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR68</accession>
    <name>A0A1C1CR68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR68"/>
    <dbReference type="STRING" id="86049.A0A1C1CR68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08602"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09613"/>
    <dbReference type="eggNOG" id="ENOG502S4W8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="322" mass="34541" checksum="1502D119B079C6AB" modified="2016-11-02" version="1">MPSVLLFGATGLIGSRLVLEVKKSHPDWPLTVFLRNTNVDEWFRTVAKADRIVHGSISDTELVRSLSKEHDIVINAISSFDGGFVANVISGMEERPPNSKGTLIHVSGTGNFIDYGKTGNFNPASKVWNDDKEEDIRQITGSMFNGATDVPVLEAGERGKIITYIVCFAMTYGPNIGPVPNLGVAYNILTSNAKQLGYAPYVGDGTAVASTVHIADAIPFLNKIVGIAGTEKPTGSAYSRYYILHGERVSWKDMSTALAKVLHRKGDLSSLEPKRVPSAEAGAGEIGALVASNMLVQGDRAARLGFKATHPSILAQMQEDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRB2</accession>
    <name>A0A1C1CRB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09279"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="124" mass="14097" checksum="08E31DF8486D49B1" modified="2016-11-02" version="1">MSRKLLILMNRHASSSPLHLPRNRHLLGRMDLAFQEENPWAVADGSSAMKMRHRRSLQAEQITMPDGDDEEEYEPNYVAESGSGSHSDQDLDGEHAWDFIFSRQESGPEPRPGRDQAVVLRKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRQ7</accession>
    <name>A0A1C1CRQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRQ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CRQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08442"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06900"/>
    <dbReference type="eggNOG" id="ENOG502SVX1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5421765at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="502" mass="53676" checksum="2F909939A8BE6E13" modified="2016-11-02" version="1">MRNAIAAVLSARSPLPQDNTATTTSSTATSTETTTASAPEATISVSIGVSTVYGENSSPVSTASALTAVTYTPAVVVLTESEPSLVTTRISVPLSGADAGPGGTTYTSLEITYTPLYSVSVVPASESTSTTGTPTSSNATVSTSSTGTSSTGSQVIVHESDRGLPGGAVAGVAIGCVIAGALIALGVLFFLMGDRLRKRHHSGTASSPGHPRHSSSKKPGYLNSTLRQRKGGAVERSVEEVTAESVLEQPKDDATIKKSVAALFKAIEDHAENYYVDTAARSDPPKEPASQSSRLPSGIMAQSDVNFEALLVDRHSRSSAITGLITAQILDAIDFFGVTERSLLPETVTKFLRSFTDQLKDDQRSRLSLSRWRTSTAALLGSADSPEQRAHSQMVIDALITDVDSVVETYIRPETNKERHLHLVKLCKRGQELGLLLLSQPTEWRFRWSDDATARRAASQTLRGEKGKKHVFVIQPQLRRVTDHVARKLDRPLIVLEWQLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRU6</accession>
    <name>A0A1C1CRU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09341"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06876"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="95" mass="10125" checksum="B70ACF7D44005A3E" modified="2016-11-02" version="1">MLEVPVPRHSVTLATCLDLEYLSGQDYTIIRLRHANANAAIRQVLLGINGSSTKAVARKSGSLISSDENFFAVMPPAKQSHSTSIAPVQGTFGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRZ4</accession>
    <name>A0A1C1CRZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRZ4"/>
    <dbReference type="STRING" id="86049.A0A1C1CRZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07894"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06823"/>
    <dbReference type="eggNOG" id="ENOG502SIYI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6161812at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1393" mass="156937" checksum="915AB170C511B285" modified="2016-11-02" version="1">MAANRPVWEARAEFLESLQNNLKHWGDLHHAENCSLDHALRKSSELRDLLVELLESLNQKLQNGTPALLEDNLTSYFDRQSSLRTVAQLPISDDRFKERASLISAALERLKGLNDALKDPFPSDVYSRDVLIGDDKVDVQLAGRMFPRASEKLKQRLGHTNWLRRSFLRHLRTEKYHGRQGRTGFTLGVTNRAEVLGSRTQRSLANQHGRLPSTITANDHRAILSRLTSSASDTASNSGTILSKADSGYVTNTATSISEFEEAPLFPAVSIPPPPNPLDASQSFLCPYCALPILVGDSESSIHHAGPYVAPSSSRNTHEESSEHAQPHAQTPQKLREATVMDVATSADWATHVFADLEPYLCTSDQCSQGAKTYSTQEDWVQHELYAHHIPNVWACEMCGHEWRDQTLFSEHVALIHGTPSEHIAAIASLSMKPSAKTPYQLTCPLCRLDCDFELYFKHVADHLQQFALLSIDTEVPESPHPVLTSYQGDKYSDLVRFIEEQSEMSQLQQTQKDDSLTGQFQRLWNDQPGLQPASGSPSKPQLSRPRIKSRGPSYTYMQRVRELKVEEAARSAATTPLAQWRSLEPTASAHSAQGTICTLQPPWNPDFVGRIDDLAKIDDTMKEKGHITVIRGPGGMGKSAIATAYTWKFKSCFSYIFWVPAETAMICADSFCEIALKVIPHAETVAEEERLVNLAREFLEQTSERWLLVFDNVDEAFDLRRFLPAEMSNTHGSVLITTRNKNLDVSHLSTSASTIDLHALKLEESRELLLKSTNRGEPVEDMRAHPEYKLAGDIAKRAEKLPLALSLIAGFVLASECTLAYFVELWNERQMSRSAQEAPADADDAMEMVWNIGLREVRTDSRQLLNILAFFDSDNIQKGLLVGSHEDPPLEMLHSHSPMRWSRMTAELSKRRLITIRTHDGEEVLSIHRKLQAKILDELNQPDNAAERRKVFERVFLLIRARFPRPSPIQVPEPHKWPTCRRYLPHILSIKRLWQTGLVEIPPSVKMAELISDAGIDLWERCLTVEGLELLRSAEAILDQGDFQEDHLRANIHVVVSLLLQDSGIANLAECRDRITKVITIRVRHREECDPATYTKNDDILLGNAWSDYGCVLLQYNNYKEAASIFDSCLEKYHEWGPPEEIPYEYAKYHHHKAYCLMYEGKFEQAVPMAEQGLHWVQVATGQSAATNRWRFDLACLVLQSGDRQRALNLHKEVLEARLKLHGKFGLLTFQSYYAVGAAHRWLGQLNEAEQYMRKVIEIDQSRPGICTEAGLAQTQFNLSEILGLRAEQVKEGGKEPRLSSEMVSALLEESAVLAQRARKVLVKPHPLGPLTKETGEHRGQQLDANAPLTADSSGVPREHELALFDHLQPVFDGRFTGLHLLQYLGDHGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT91</accession>
    <name>A0A1C1CT91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_09045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT91"/>
    <dbReference type="STRING" id="86049.A0A1C1CT91"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09045"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06382"/>
    <dbReference type="eggNOG" id="ENOG502T2UE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="49"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="243" mass="27338" checksum="C801518890A0505B" modified="2016-11-02" version="1">MAGWFYITSDMDPYPKIHIPHTYPEKGHHLHHISTIPYVAHNLYSKFHDKDLDAHQPKTDVRETTRNFYLEVELPGVKDHAELRLRWTNSRTLLLTSKTTRPEIPEEELLEEPAPAAAASTTTTTATASEAGARQQNGGDITTATTTDPKTAPPEQKPKPKLLAPHLTIHERPIGEMIRAYNFPVDVDRDATHAKLDAGILRVVVPKVEHTPPATDKDGEEKHFLHVPVRILGHGHDKEQKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTB0</accession>
    <name>A0A1C1CTB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTB0"/>
    <dbReference type="STRING" id="86049.A0A1C1CTB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08263"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06372"/>
    <dbReference type="eggNOG" id="ENOG502SAP5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3344043at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="618" mass="66174" checksum="431FFE288CC75705" modified="2016-11-02" version="1">MAVTREKKRHSGGKRIIFASLALIVVPMIGLAGLLLGLVLVNNVDKPADRSSGSLTLDLRSEFDSGAYYVDFNPTTLVTIASWSSTVAPLLAVCAMILGSFPIAQSLKANSQMAGSELPTPFQFSLLLDCLSAGITPLWNALSYWRWPQKEGAMASNVRNALTVLATFMALGYTIAGVDTWLHLVMEAVNIELVDVQVPSQALGRGLPDGPCSRQTAAGFDAGDCIISLGATSVFLTGANEAARVMSNTSSTNAIYDMYIDDTHFAYLGPAIIPSNLDYRAESLAIHTQCRQMGKQCNLGFNQSGTSEPFHCTDAFYGDLGQPIINGDDTDAVSGLAFRSAGIVFYRDAGLTQLANKSTETESFLTRPSNPQHLAAWAKVELGATSLQTADGNVVTPTRGGTSWPLNCSATAYEITYSFINGTLQHATAEVANGSVGTILAAGNYYGFGKVALETAAYSASQYNNTAQMADAWARAYSRTAMALGSGIMTARADLEEQLRSSRLVSRVPKAPLYTLVALNTVYAVLGFVLAWLALGSNPSETNELREKLSTAGLVAFCFEGDRAERVVDRKRQMFAEYEGAPSSRVGVEENIYQGGYVFRLRHGPHKAASYDMSVDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTH2</accession>
    <name>A0A1C1CTH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08605"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06310"/>
    <dbReference type="OrthoDB" id="4153356at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="377" mass="41756" checksum="325735329B45C5C0" modified="2016-11-02" version="1">MPGKKGGKRRGKKAVKNGDDTQAGSDISYTSNVWQKRVVASEIFISPTVTTGEGTRKLIQIANQGVLTMLQMAEFAAQIREFVQGSTDADHDHRYIYYSSLLQNIEKRRQQGARFKERQARRELDKRLEPYELQKLRYHAATKLANDLVYKFEQVGKVARSLLTSQEELGEEIAVGESGRKKIVVSAKCIDTLWKDIITTHTQLKKLHDEIVVVKMTLPPVPGRLKPGEIDRGEDEAGNKLGRETVWVYDPTNMVGGDKLVIGEDGQIEGLDTDESVRAEGTPRSSDETTLVEEFDDQCRIGSPSGYAGTVSSTSAPGTPDTKDSSKATSEEKSKQRDVKEGSKRKAEEGDSAVSKEDAEVQDAAYESDRELLVVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTN9</accession>
    <name>A0A1C1CTN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTN9"/>
    <dbReference type="STRING" id="86049.A0A1C1CTN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09118"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06276"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="173" mass="18889" checksum="A323DB846DB5EC02" modified="2016-11-02" version="1">MSTAALQSSTSSISLPPISSIDFHTHMAHRSEPEVVQPLPPPPPAQQRVLPPLPYPYAARPAPPPVPPPPMPHEYMQARPMYPGIPSPYQPMPGRMALPSTTDPSLIVASPRHKAKEVKRRTKTGCLTCRKRRIKPRRPLAGKLDGVGAWQGQATERAWGEGNFTRSSTRASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU29</accession>
    <name>A0A1C1CU29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamyl-tRNA (Gln) amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU29"/>
    <dbReference type="STRING" id="86049.A0A1C1CU29"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08180"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06122"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058329">
        <property type="entry name" value="Arp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26053">
        <property type="entry name" value="DUF8016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Scytalone dehydratase-like protein Arp1 N-terminal" evidence="2">
        <location>
            <begin position="39"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="159"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="625" mass="69050" checksum="E649830AF9CDA194" modified="2016-11-02" version="1">MATGLEPFLNIGSDTYHILLDPKASSLPPALIPKLRRFQEEFVPATVVEWTPSIFTPADLRATCRSFASTDDVWNPDFLSLIILLQPATVRGGFKKKRIFSIDKSRHDLAEGPYVVLKATGQIFPVSKLVPDPQQAFVSGIYQKSASGTTWCELPLYRGYSDKPLAGLRFAVKDTIAIKGLTTGFGNKAWADTCPVERTTAPVVRLLLEAGAVLVGKLKTTEFAEGVDPCEWIDDVCPFNPRGDGRQKPSSSSTGSAVAAASYDWLDFTVGTDTGGSIRHPAGVNGVFGQRPSCGLVSLEGILGAIDLFNTVGIFAREIDIFTRVGSLIVSRGKPQSYLAENRRYNLLYPTRAAQTDNPDPHHHGQHRWFPHPSVDPKYWSEAEKQIDATLREFETHFDCERIPFNINDLWRATPPIGQSRSLDESVGPIYSAVTTASAVACGLDQFINEYRAKHGKPPKMSNLVSRRLDHGRNVRAEDLSNALQAMQAFKLWVETTLLGSYDQDATTLLIFPQSCGRPDYRDDVPDRSELFNDTFSIYSFGHLVGCPDYTIPVAETTYLSRITNQTEHLPVSISLVGRPGSDLELFNVVRQMRDAGMISDVATGSRMYPERRIDAVGTEIHHPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUS0</accession>
    <name>A0A1C1CUS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_08412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUS0"/>
    <dbReference type="STRING" id="86049.A0A1C1CUS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08412"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05912"/>
    <dbReference type="eggNOG" id="KOG0646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000929">
        <property type="entry name" value="Ribosomal assembly complex component Ipi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="185"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="504"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="535" mass="57979" checksum="0B10A9BAB2BCD14E" modified="2016-11-02" version="1">MLTESFVAATLAANKAAAHATAALKDVGIFLHEFQPQSTLRHGFKKSSSQPDCVAISDSHVFAAQADKAVVNVYNRERGNQEATVPFPERIHSVAYAKFADILVLGTEGGKLILWELATGRVTNSSASHLQAVSRLCITPKNEYILSGSADSSIHLWSLARLVSFEQLSDSYGSEEPSNAPAQTFSGHRTAITALACGHSLISTNFAVSASDDGTCYVWHISTCQVLRTLLLPSLPVSITLDPADRAIYFGCNDGRIQAWDIFMHVSKLNVPLSSSSQLPPIQLLDKDSWSAPSSDLGSANCLTISYDGTALLSGHANGAIIRWDVAKHRILNEITNLGQPVTNISMLNPEGFPNQKKAKYVISQVIKPNLEFSSMRNNGTCGIPANYGLHVMIANSTTDPEHDDFEHALTRPGISQAMLDAAVHSLALGSAPQGLPSTDTTALAKTERLEEEVTKLKQQLAAIHSVEEKRKARKLARIAKRDELGMKKREAYFDAKKLGKDGDAAMKSWERKEAEVDQESDEEALGDGDQMDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVP0</accession>
    <name>A0A1C1CVP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_09956</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09956"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03912"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="77"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT52515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="529" mass="58203" checksum="F27BD3AAF9088651" modified="2016-11-02" version="1">MLQKLYSVITTGPREAIRGRRMVRGPIEKSASLEGLLAILNDPDRINDQLRSQLAGFDREELAQGIRSIKRLLDCCLIAMAWAMFACNYFDRSCLASAELMSLRTDLGMNSNEYGLAMMLMFIAYVLAQVPSNLYLAKGRPSIYLPTAMVLWGSVCTSTAFVKTPGALYAARSLLGLLEAPFSVGCLFLISSWYTRTELGSRSAILLSAPMMANAFTGVIAFGIHDSIDGAYGLEGWRWLFIVGGSVTIIIACIAFFTLPDYPHNTRWLYEEERALAQLRLTADRGASEYDVSRVVGLKMAFNSWQVWTFAGMYFLLAIGTSLHNFFPSVVQTLGFSRNTTSWMTAPPYLLAVVVAISAALSADRLRNASFHIIGTTALAIVGFLMFLLEQSTDRGDVWARYASTFLMIAGAHAANPIVLGWAQKTVRQPREMRATAIAIVNTSGTIAQIATSELYPKRWAPRYIQSMSLNTACALAAVLLAIFMREALRRANKKLDLVGNPIGVEAQTPGPSNNEQRQGVVSTHRYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVY8</accession>
    <name>A0A1C1CVY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_10536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVY8"/>
    <dbReference type="STRING" id="86049.A0A1C1CVY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10536"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04044"/>
    <dbReference type="eggNOG" id="KOG4600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000042">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="285" mass="31122" checksum="EB9CFCC34865EEC2" modified="2016-11-02" version="1">MLQPRIHRPVVAPDASLAALASSLNALALCSKHTHTPLQPRSSAIFVRHASHAQQGRANGPSDSAGRRLGAKKGSSEWVHPGNIIFKQRGTKWFPGENVGIGKDHTLFALEYGYVRYYRDPLKHPKRRFIGVALAKEGPASQLPTPRNAPSRRRLGMYAAPMKPPPGAQKSVDASFLEAHLSASSSGRGTPAQVAFRSGRVVPTPAPPAPFNRQGTFREANASIGRAAERKGVKVREYDRSDRWLAWRKRALRVKRGMAAKAARGTKKTKGKKSNKGPKTAQRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWP0</accession>
    <name>A0A1C1CWP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NOP9</name>
        <name evidence="10" type="ORF">CLCR_09720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWP0"/>
    <dbReference type="STRING" id="86049.A0A1C1CWP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09720"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04197"/>
    <dbReference type="eggNOG" id="KOG2188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="641"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT52856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="710" mass="79989" checksum="33502EB5C8DA1F5A" modified="2016-11-02" version="1">MPREVKKRGRRHQEKERKDKESDRYKRSSKRFKTEHIAAEETAAEVAVSGDAGDDFIGFNIEEPRGVEEPQEEAQFYGLLEPQEQEYYANVNNKIVANDFESPEDRGNFIEAVHRETEWKELKVASSQSCSRYLEKIIMLSTPEQLRRLFSIFVGNLTYLVRHRFGSHCCETLFLQAAKHVEKDNPKKSAEREELPSMETLFLQATEELEPNMGFLLTERFASHTVRVLFLVLSGDSLDDESVKTMLASRKKEKLDAPVEKESVSENGRVVPKSFRIALDRLISSGVSTLDTTYLRALATHPTGNPVLQLLLHLELTGPGKNKSSTENSVFRKLLPDEQLEEDSESAKFIAGLVYDPAGSHLVEILVKELPGRAFKKLYKNILKSRLRSICKNDTASYVAIRMLERLGKDDLAEVKGLLLADLPLLISRRRTGLIRVLVERCAVRGVDLQDVADVIRTEYTKDNSDFLSTLLDLPSSETAEKPHDVAEDKEAASKQAHRTDVHGSLLAQAMLRAPKMSQLVQDSLVAVDMSTLIAMCQDPASSRVIQTALAPTQSNIPFRRQFVPRFYGHIAALAQDLTGSYVADALWSATEGLHFMKERLAEDLANHESTIRESPFGRNVWKNWAMDMYRRRPGEWRALAKGQEHDQPRDAPPQRQGQGARPGRNESASVKKKSAIELARERHAQKKSQTTNKKHTPATSANAVVPTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWT5</accession>
    <name>A0A1C1CWT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWT5"/>
    <dbReference type="STRING" id="86049.A0A1C1CWT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10798"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04266"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="144"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="225" mass="25308" checksum="55251B2C246A0E9D" modified="2016-11-02" version="1">MALTSEFQTNFGPSTNPWDFELPDDLSFIPGAAHESALDEFSRLPAPTLSTLGSQARMPEFVQPQNLHAQDADASASSPSSISQASLPRRTGSIDSTSTSTSLSREQFLRRLSLATSDLQEDSYRPRNTPAKRKKMITGRITPRSDKHARELELNRKAATKCRNRQKAFIEQLQHRCKREEEKMHIQSSLVSALHDEVVALRNELLRQSFCDCRFLSTASMSTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWT7</accession>
    <name>A0A1C1CWT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tubulin-specific chaperone c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_11406</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWT7"/>
    <dbReference type="STRING" id="86049.A0A1C1CWT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11406"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04357"/>
    <dbReference type="eggNOG" id="KOG2512">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031925">
        <property type="entry name" value="TBCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16752">
        <property type="entry name" value="TBCC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="8">
        <location>
            <begin position="207"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT53017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="411" mass="44286" checksum="A67AFAC257034A1C" modified="2016-11-02" version="1">MAADTSTSPSMASPGPELSHQQRFFQFFQHEITALQEQMGRLADTALIGGERTDAMDHCLAGITRLSAELKDAAGYLPPYDQRTYGEAVKALQEKLEETRRSHAPKPKFSFKSKSPSALSLSDAAELAAEKRKGGGPGFASPSTSTSFANTPSYINTPANEVAQDEQQTIEEEEAEESAERASKATINTETKLQPPPADPAKNIDRPSLSTTTSSTAISNQSNTHIILPSSAPNARTPCSLSKLSRCVVDLSVPTTAKSPFASITITSATSSLLLCGSVSGPAHITGVKNSVLVIKCRQFRMHDCENVDVYLHCTSRPIIEDCKGIRFAELPKFHSDLISSLQEDPTAVPNQWNQIDDFKHLDASTPSPNWSLLSAENSVPDESWREIVPGGPGWSVSDILTAVHIPVARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXE7</accession>
    <name>A0A1C1CXE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative NAD dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_10284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXE7"/>
    <dbReference type="STRING" id="86049.A0A1C1CXE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10284"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00134"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="349" mass="37777" checksum="CFC19B61F970FDFA" modified="2016-11-02" version="1">MSPPTVLLTGATGSLGASTLAHLLSDTDFAVVATLRSSAKSEPFLRSKYAAHVSSGRLSFVEIPDMTAPHAFDGPASSGGVDAIIHIATPLAYDDVVNKVIKPSWTIVHNVLIAAEKSRRVKRVVMTGSLVATMRIPEGLFAGGSTISEADWNPITRDEAGANPSTAYQYSKVHAEKEAWKFMNEQPRAFDLIFLLAPSITGRSLQGGFKPEKGHLGGQPGLNTGLFDVERPGFLFPMFADVEDVARVHVEALSPRIPGNQRYLFHSPELMAPNPIAAAIREEFPQLRDRVPAPDEGSGSGEPANLVKTDQSRFESAFGKRTWKSARLSALETVQDIVDYERRSEKQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXJ0</accession>
    <name>A0A1C1CXJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_09676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXJ0"/>
    <dbReference type="STRING" id="86049.A0A1C1CXJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09676"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00264"/>
    <dbReference type="eggNOG" id="KOG0273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="579"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT53297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="684" mass="74162" checksum="6ECA9C6460C03E85" modified="2016-11-02" version="1">MEADNASTFSAKPPPLSSDQLNYLIWRYLQESGYADAAVKLQRDWRVDAESLPFAKCVKGHALVSLVQKGLRYHHLSLTIDENGRPSKQLNPSMFFFGPESEKPPLELPEEALPSTPSPHDSLIAPQKQIRDPAANGLVSLPVASQLAPKRGRKTAASSERNGSATRKPSASANRAANTSAMDVDMVNGHTLPISDARSPTATDLGPDDAGPFMNGIKADERMDVDEDSLVADQHNHEPQIEVVPPPAHTLLIGESRGVQVTPAKVVNLAQSSAIFNLPPPAVGDVPRSLTRVTWQPSAGNALTAMGDDFCGIWDITLGSPTSSTSRFQELVDSTGQKLISAVAWEPHGDMIAIATYTNLSGHIFVFDGQELCMVEDLTASQRAVTGMIWQAQGSSLFGLAPYDSDDISTTKAAGSSIIQWHHRNLPAEVELSTVRVPETLMDMDGAFLDENGIVCAAGQNSVYSFRISPALGIEQKWTSDPTANDQWTFVRCTLRWGTSPFLVAASAETGTLWMPTQNLFKRGAHEAHITGLELRPRPATPLNASSRQEFATSSMDGTIKVWRYDDDSDSITSVCKLIVGHGSPIMALSYSPDGFCLAGASYDTVRIWNSEHDHNHMATWKDEQNLWHGSKLKDDDMMSTGGRSSVNGDAYQVTADHTLAWDGDSKKLAFGLGSQVAIINFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYK6</accession>
    <name>A0A1C1CYK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dsp1-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYK6"/>
    <dbReference type="STRING" id="86049.A0A1C1CYK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10022"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00575"/>
    <dbReference type="eggNOG" id="ENOG502SAS5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5054775at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021711">
        <property type="entry name" value="DUF3295"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11702">
        <property type="entry name" value="DUF3295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3295" evidence="3">
        <location>
            <begin position="74"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="549" mass="60281" checksum="84AD0D6AA67B7563" modified="2016-11-02" version="1">MPSRLNAPPVLSLDRGKMHYIDPSNACSLMAMWSIFSKCSETLEEGPRLENLSWRVWSRESLCVTPIDNPPRASQVPSLSSSWSSSDSLADLRSIPVKIRHRSKSPSQHDCASSLSKSRHLSPVTLEKMVATIQEKTDLGPLSPSLEASPPFTRSFSPEKQTPPKSERAPEADHAIQVKNLQDSTESCLSTTTTTATISTQHQSEHRGSDTSVSSDGLIRSGSIVHGFSPVASSCRSRTISSSLKPVAPTKLIPQAKAGLKATAMFTLGGSSEDDESSFEQRVLSVKTAPQRSSLSQNLSRQNLSGGKSQLQPKRTSFRDVVAQRRIQEDAENDEGAIESSDEEDDTDEVMESAIDEDEEDADDWEDSNSDDGKPSQEPHLFRRVESRPDLVSRRSMLTLALNKGQGGLAHAYSQPALHRSRKSSPPQGPSMANSPEDEDGMVMQTSNRPPIAVPPPRSSKPLAHSPRTTRIHMLSTELTESLRRNLLLERREKSHTANAFLKRSRNAQSMANLTNIGRATGGPAPVLDTSRDENWTVDNTWEYNTKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYV7</accession>
    <name>A0A1C1CYV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L21-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl21b</name>
        <name evidence="5" type="ORF">CLCR_10679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYV7"/>
    <dbReference type="STRING" id="86049.A0A1C1CYV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10679"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00629"/>
    <dbReference type="eggNOG" id="KOG1732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="158" mass="17961" checksum="5378BAD472D9A18E" modified="2016-11-02" version="1">MGHSAGLRSGTRYAFSRQHRKKGMIALGTYMKTYRVGDIVDIKANGAVQKGMPYKVYHGKTGVIYNVTKSAVGVIVYKKVGNRYMEKRVNVRVEHIAHSRSREEFLNRVKSNAQRRREAKEKGESVQLKRMPQGPRGSHKVDFSEVESLAPQPYDTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D001</accession>
    <name>A0A1C1D001_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D001"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11100"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00924"/>
    <dbReference type="OrthoDB" id="4160782at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="82" mass="9309" checksum="13CB670E0CED5AF7" modified="2016-11-02" version="1">MTLKKFIFVFRSSPVCRATLKNKLRHIIIRGAFKAWKPSAPDTPSFVVPRDLFYQDITAPVLDALSQQFQLLRDSHASAAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D065</accession>
    <name>A0A1C1D065_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D065"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00178"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02603"/>
    <dbReference type="eggNOG" id="ENOG502RARJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4116414at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651176" evidence="2">
        <location>
            <begin position="20"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="443" mass="46980" checksum="AB077F4037777BA0" modified="2016-11-02" version="1">MVLYTLVLLALAVFGLADAVSVSSTDTDTPSCTLTFTATQPPQIGPTTTIYQAIMTTFLYAVDCDICTVTNTPSALIQGPFEVRSTSSMLTITQVECIPTGRASTRLHEFAHGNMAAAATQTPAWNNMKGFTSSDLFRRSDQATEASLANLAMDFASALPPDVALLSGGLRDEFTNIASAMFALSVCDSGLNLTAACAGLGTAQTKLELLQSWYNPDNIQSIVCFCSMYGYDFGTTRQQLYANLYAALIGVLAAADVTTERGQICDTLGLFNRTGGSLGIDTQLYHELVCSNIPSATPTTPIWYGPTPIIPYVTNNMTTWGTPTSWAPNMTITGTGIPTSWAPNMTVLPGTGTPEWNGTGNGSTWGPPLSFTGTIGSDWSLTINTQTNWTDSQPTGTGPASETGAAASNDSLIAARTPRGRNAMPFYPAVSTPTQRPSLFKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0E9</accession>
    <name>A0A1C1D0E9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamine synthetase</fullName>
            <ecNumber evidence="3 11">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">glnA</name>
        <name evidence="14" type="ORF">CLCR_00253</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 11"/>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0E9"/>
    <dbReference type="STRING" id="86049.A0A1C1D0E9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00253"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09430"/>
    <dbReference type="eggNOG" id="KOG0683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="12">
        <location>
            <begin position="29"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="13">
        <location>
            <begin position="115"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT54186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="367" mass="40823" checksum="56D292888516D4FB" modified="2016-11-02" version="1">MAAGVGESTIVSNASNLAKYMKLDQKGKVLAEYIWIDGSNGLRNKTKTLSKAPKSVDDLPEWNFDGSSTGQAPGDNSDVYIRPVAMYPDPIRLGENVLVMCETWDPDGTPNKFNFRHDAARLMEANAKHKVWFGLEQEYTLLGPDGWPYGWPKGGFPGPQGPYYCGVGTGRVYCRDIVEAHHKACMYAGIEISGTNAEVMPAQWEYQVGPCEGIDLGDQLWVSRWLLHRISEEFGAKVSFQPKPIPGDWNGAGLHTNVSTKEMREDGGMKHIEEAMKKLEKRHLEHIKVYGEGNELRMTGAHETSSIEKFTWGVADRGSSVRVPRACAREGKGYFEDRRPASNADPYQVTGMIVETLFGSLPEEKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0I7</accession>
    <name>A0A1C1D0I7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_00275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0I7"/>
    <dbReference type="STRING" id="86049.A0A1C1D0I7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00275"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10202"/>
    <dbReference type="eggNOG" id="ENOG502R3M8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF697">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="53"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="353" mass="37681" checksum="9E6B23C585B537B3" modified="2016-11-02" version="1">MSIRSNHSLSGDNKMTTTEKSNGVDSIHSVKNGEVDDNDFEVFKDTADVHFRTVSWVHATMIFTKIQFATGVMSIPLSLYALGGVGGGISIVCWGAVNTYVGKIQGDFRNRHAGCHSVADMAKIVGGPVLKEIIGIEFMIAYVLSAGSGILGTSIGINALSMHGACTVWWSFLATIFISLVACIRKFEKLSWVTLVGFLSVFIAVFIVVVGVTTIDRPAAAPQEGDFELGFHAIGHPTFMAGMVATSTIFVSSAATSAYMPVISEMRKPREYYRALYVTMGFVTASYFAFSMVVYAYCGQWVATPSLGSAGPTVKKIAYGVALVGLVISAALYLHVNALWAPSGHPPCSLVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0V9</accession>
    <name>A0A1C1D0V9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_00855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0V9"/>
    <dbReference type="STRING" id="86049.A0A1C1D0V9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00855"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01608"/>
    <dbReference type="eggNOG" id="ENOG502RXDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="470" mass="52181" checksum="AAE538A88165705C" modified="2016-11-02" version="1">MAFRMMRDLGIHIDSKKMSYLARQFSEEELALRQQVFWSCFTWDKTMSLCLGRAPIIHDTLDIPSRETLIDGQEMDDEPWRPVLGQEQESMAAFTEQKLLGSARFGAYCRLCIIIDGVLDNLYCRPHRSKQDHLLAFLEITIQKLEDWSTSLPAGLFISIGDRAVLCPPIHILLLNLTYQATIILLCRPYRTLSPRAKDLCTKAAQMIDSLFTLHVRRFGFRFITYLQTYTMFVACTINVLDLKENESCKRRSGDGLVLAQEASVRLNFGLEVLRQAGATPSAARCAAVIVQLLRQWSDKKVLRGAIQSSRDHRGHIIVASPRASPPSRSCAASAAGVLVEPTTGPAQTSERSPSHAPPASNSLPAFSPEVGSSSFQFHASPSTAQQPQVRGRALNSAPSPSVQNSMAYQYNGSVSLEQLCPNESPYADASISNFVNMGIETPMRWLPDNIVDDGSWMLMTDFGNGFLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D123</accession>
    <name>A0A1C1D123_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_00773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D123"/>
    <dbReference type="STRING" id="86049.A0A1C1D123"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00773"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10099"/>
    <dbReference type="eggNOG" id="KOG2316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="7">
        <location>
            <begin position="64"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="869" mass="94521" checksum="AD91A4726867D93E" modified="2016-11-02" version="1">MSDSLNVIALISGGKDSLFSILHCLEQGHKLVALANLYPKPCEGRGIEKRRPSTPDGTTDSEGEDLNSFMYQTVGHSVIPLYAECLGIPLYRRQIAGSAVQTGRYYDASNLGSTPDETEDLLPLLREVKRTHPEANAISSGAIFSTYQRTRLESVAVRLGLTPLAYLWQYPALPPPLGRGESVTGLLDDMAAAGCDARIIKIASGGIKESLLWSNVADPRTQLRLVRGLQPFFPEREFWLRGAVVGEGGEYETLAINGPVGLWKRRIEIPEEQMSAYSGQGGVSYLRLANPRTVENGPDTVPSGTSLRVPGTFDPQFQAVLAEMQSQQTQTMNGVSEVDELRTNADAKRHRQDITVHLRKLQCLCSNGLALSNITSEVTNLTAGFGTAAMQMKQICHDLKSSLDTISSSGGLSNPPTPSNIVFTMLLLKDMSNFGAVNSVYASLFRTGEPNPPARVTVACSLPDDVEVSLSVILDLGPRDARRGLHVQSRSYWAPANIGPYSQAICVPLDVKQDPALNVHDSDLVEMAHMAGQIPLVPQTMQLPATDFLEQAALSLQHLWRVGQEREVDIWPWGIAFLESTETASVRAELCSRVWQQAHNVPGARPQDVLDGEESDEGPDAWDLQYNRAKTYEAPTATPLQTGRHLHPLPNAAVFLQDNPNIGASVTPPFIAAEVISLPRSAPVEWWSMGITNLPKRPASRPRVSVARKDHAWGSLHKVTLSASSEPTTEGYVVHLVTITLREEAISAGSIDGDSRIRDDLLAFVSVDRGPFKQEAPSAEVVHGTAFVSAPGWDHWSHLRRDGLFQTLVVVPCESVYGWSNPAVNNVGPWGPARENPSVPTTELKRADGEATASPTQRLAVAITMRIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1A7</accession>
    <name>A0A1C1D1A7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1A7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00971"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="173" mass="18711" checksum="526E2AB24785A08D" modified="2016-11-02" version="1">MVPLQGQNDSHSTETIASDTIDSAVGYLSLRQQARPWCTYLTLLLIDASSRVAPIVKRQAANPSMGAYRVILSLAHAQDCLRDLAKSKLSVTRRALVRLNEISDDVNVAYSLATSIPEGIDAGKDAVARSIDKSVSPGLLPMDDWMFDTSKIWHAAELADLLSSEAFPLDSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1F7</accession>
    <name>A0A1C1D1F7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1F7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03205"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04679"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="99" mass="11321" checksum="6163FA0389835C50" modified="2016-11-02" version="1">MGSTDIKFPIRYEDPEYQSNHRNLFSGVLLSPLENVLPPGVSQQEFDEAVTDFENAVGRDHVFRGQSLEEYVDPYELWEKEGKRKMPSAAVWCVLLSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1Q6</accession>
    <name>A0A1C1D1Q6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_03062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1Q6"/>
    <dbReference type="STRING" id="86049.A0A1C1D1Q6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03062"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04799"/>
    <dbReference type="eggNOG" id="KOG2352">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF80">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="61"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT54692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="229" mass="26062" checksum="6411DE1D64FEB4CA" modified="2016-11-02" version="1">MSMSEAELKRLAHAEYWDERYAKVGPEEQVHEWFRSFKDLAPFFDRHLLQVRRPETQPRILHLGSGDSTIPEDLAKRGYKNQVCVDFSPVVVETMSKRHADVGGITWLHGDVRQMDQIPSQSVDVAFDKGTLDAMIHGSPWSPPDEVLENTGRYVREVFRVLKSDGTFIYVTYRQPHFVKPLLNCEGATWDIQVDVLGGSESSFDYHGFVLKKVPSPVGNVKSEKGDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D235</accession>
    <name>A0A1C1D235_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_02877</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D235"/>
    <dbReference type="STRING" id="86049.A0A1C1D235"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02877"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04914"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT54822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="510" mass="57549" checksum="E16A96A781BBFCE2" modified="2016-11-02" version="1">MAAMSMPHVPVAVILIAIVAVYAIQRIYYEMTTGARRRQMIKDNGCEEIPWYPHQGILGKLYGVDRIKDMVAAAKQGRMNEATRIKNFGDGKKTLRLRLASSNIISTIEPESIKTVLSTKFQDYSLGERRKEVFLPVFGHGIFANDGAAWERSRALVRPNFTRQQVADLDMFEVHMSHLIDSIARDGSTVDLQDLFFGLTMDSATEFLFGKSTNTLAPGLETKSANEFVKAFVYVSGACAKDFRSGGLAKFIPDARWRKSVKIMHNFADAIIHEAIEELRTGKQDPNGRYIFLHALLRQTQDPYVVRSELLNILLAGRDTTAGLLSNTWHVLSKRPEVFAKLKAEVDQLGGAKPDYTTIKEMKYLKWTLNESLRLMPVVPSNSREAIRDTVLPLGGGADGKAPALVRKGEVVGYSAWSMHRREDFYGPDALEFKPERWERLRPGWEYLPFNGGPRICVGQQYALMEASYATIRLIQTFPRIESRDDEEWREWMTITLASGTGVKVALFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D290</accession>
    <name>A0A1C1D290_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D290"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03193"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="115" mass="12709" checksum="EF69B10522914854" modified="2016-11-02" version="1">MASTMIRFPTFRSTHTADDKPTAQQSLREILRKASESPVTITSPSSSPSRSRPEPVGPHSSQHHDEKTRTNSISTTSTGTSSRWSPPTSTSTPRSSQSSSNSHEEKWNFNFFTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C648</accession>
    <name>A0A1C1C648_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase chain 2</fullName>
            <ecNumber evidence="3">7.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH dehydrogenase subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ND2</name>
        <name evidence="13" type="ORF">CLCR_11468</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="13"/>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000023">
        <property type="protein sequence ID" value="OCT43967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C648"/>
    <dbReference type="STRING" id="86049.A0A1C1C648"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11468"/>
    <dbReference type="OrthoDB" id="4092844at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22773">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650589" description="NADH-ubiquinone oxidoreductase chain 2" evidence="11">
        <location>
            <begin position="17"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="12">
        <location>
            <begin position="143"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT43967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="538" mass="60389" checksum="D87FDEFF3663B6A6" modified="2016-11-02" version="1">MILTFLLLLLFSNGLSNRPDTSILYSRIGILIVFYSLISSYTTLYITYLEKGIGLYGGLFNISAITQIFQIFILIVCGIILLMTAFYPRKKYIGDSNTMIDVLFKKVKEYTNIINKVSEQFTLIEYALIIIFVISGATLLLASGDLGSIYLCIELQSFSLYIISSMHRNSESSTGSALTYFLLGGLSSCFILLGIGLIYANSGLTNLDGIYSIISDSEKYVDYSTWYMHSYIFYSLLLISVGFLFKIAAAPFHWWSPDVYDGVPTIVTTFIAILGKIAILVLLLELVQYSSCLLQSTIQYYSWTTSLSISCFLSLVIGTILGLTQTRIKRLLAYSTISHVGFMLLALIVHNIDSYQAYIFYIIQYIITNLNAFLIVIAIGFSLYLYYTNISEYNNLQEKNNSPIQLISQLKGYFSINPILALCLVITMFSFIGLPPLVGFFGKQMVLTTALDNNKVILVLVGVLTSVIGAVYYLTVIKTIYFDNSQYEKTYMYIDISLSNIYSITLSIINLGIISFIFMPNEILNLCNLLSIITFSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6A7</accession>
    <name>A0A1C1C6A7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_00132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT43992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6A7"/>
    <dbReference type="STRING" id="86049.A0A1C1C6A7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00132"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02054"/>
    <dbReference type="eggNOG" id="ENOG502S0US">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052174">
        <property type="entry name" value="Flavoredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43567:SF1">
        <property type="entry name" value="FLAVOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43567">
        <property type="entry name" value="FLAVOREDOXIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="4">
        <location>
            <begin position="15"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT43992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="241" mass="26165" checksum="674CB57A5C8CF840" modified="2016-11-02" version="1">MAHQEISPAILYWGTPVVLISSTNPDGSTNLGPMSSAWWLGSGAVLGLDVSSQTTQNMLRTKQCVLNLASDNMAANVNAIARTTGTDPVPESKQGRGYTFVKDKFKSAGLTPLPSRKVTPPGVKECPVVMEAEVVAVHDMFGGRAVQGLAVAVEVRILRISVHQELRLNGHRNRVDADKWKPMIMMFCDLYGVRDGKLEPSTLAEMEEEMYRPLTETTGEVEGELDSGVAEHVIELSASQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6B5</accession>
    <name>A0A1C1C6B5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcofluor white hypersensitive protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6B5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00143"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02038"/>
    <dbReference type="eggNOG" id="ENOG502SSX2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5355126at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="131" mass="13872" checksum="E841C78F1237D093" modified="2016-11-02" version="1">MSSNRAFTLLGVAAAGGVGYYLYNAGGDPKVAQKKFEADASKVSSQIKNDLPGREKEAKKEGEALANQASHKFDQASADAKTKLSDAEARAKELSQKTGKEINSAIDKFDKTVEEKAAKAKSGISSWFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6G1</accession>
    <name>A0A1C1C6G1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">swr1</name>
        <name evidence="20" type="ORF">CLCR_00544</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6G1"/>
    <dbReference type="STRING" id="86049.A0A1C1C6G1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00544"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00997"/>
    <dbReference type="eggNOG" id="KOG0391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140849">
        <property type="term" value="F:ATP-dependent H2AZ histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000655">
        <property type="entry name" value="Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSA" evidence="19">
        <location>
            <begin position="354"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="793"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="1349"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="149"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="480"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="720"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1569"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1639"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="572"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="626"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1575"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1653"/>
            <end position="1662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCT44058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1662" mass="188858" checksum="6ECBA59770FDE85F" modified="2016-11-02" version="1">MPTPTGDSLTHSNTPEQQRQQDPLHYRRQSPVRAHATPPNSSVEHHDSHEDANHEPPAKKRKVAGPEHKQSPRPVSPPWRRVVAEGPTSFVVDGRRKSGRTNIIPLDLQPQSNKRQTRAAFDKVKEEHQKHAKPVYNINMSARKSNCDVVVPSRSPSAVKRAAVPPTKSRDSATHAHIAKIESLQRQIKELEKARSKTSHTPQPKSSKSPSRPVSAGGRRRRPNSLKVDGAHKEQRPVNGNDKIESESDSSDLDSSLSEPEVSSRAPTPPLALRKVIFRVQLPPPTVATPANIPPSKKFASFEEFLEKDETEPRLAEDTLTQDQIKKEAMVRTKVRQAQKRGGVLDKKLMDTLPKQQAEPRRQYAHHDHLLAHVLHFRKLLEVETKDHRRKAQILACEAKKYVEDKQSRNKVKTVAEIVQEQREACIAAYRSVVKDVDKLWTAVRVEVNAMRQKEYEEEQQAKMKGHLARVLDRTDQMLSRAAEQDDTTTDTDTDMSVDEAMDSESENSEQMSDSQTESESEPDSQDADAEMSLEELKKKYDNLHDQLMETENAEEAPGPNEDRPGPKLDQEESDPETEMDSEFDTDGSEDEDEDEDQDQDDDEEDESEEEEAEPDLLSMLFSKTQRAEIEKGADQEAEKGEFGSRNTDLVEELPEQPRQDGDQSEGPGVPDHIASEKVEANVTERLGVKLEVVASQQGEDAVIRDATSPSHLEIPHLHSEDAVSQDPSTHTSPHTTATKVSDPDSVSSIDAQIDPAPPATPSDTKPTIETPVPSLLRGTLREYQHEGLDWLANLYAKGRSGILADEMGLGKTIQSIALLAHLAEVHEVWGPHLIVVPTSVMLNWEMEFKKFLPGFKILTYYGDQTERKEKRRGWLADDKFNVCITSYQLVLKDKDSFKRRRWHYMILDEAHNIKNFRSERWQTMMTFNTRARLLLTGTPLQNNLTELWSLLFFLHYGQEDQGEDDAFAGLKEWSEWFKRPVESILEHGRQVLDEEDREQVAKLHKVIRPFLLRRLKADVEKQMPAKYEHVEMCRLSKRQRQLYDGFMSRAQTKETLASGNYLSIINALMQLRKVCNHPDLFETRPINTSLAMPKAASADFEIKDFLVRRRLMLDASNDLDLDFLQLAPISNEGMSMIEAIETSKRHAYHQFKGLRESQSRRILASPGVFSSNAPSASAWRGDNRIGVLGSLENVGRRARLQELDRTMYYEAYRHHQHPIYGRGLIERVTIDAKYERLSRLSPPRVLSKCWESEMPVHFFDMVHSVQSRSEQMQPFVEGYACVTPSVVATDLSTRAVTEAGAQLIREAVQTTWRSDRDHPDPFHLARMKLSIAFPDKRLLQYDCGKLQRLDKLLRKLQAGGHRALIFTQMTKVLDILEQFLNIHGHRYLRLDGATKIEQRQILTERFNNDNRILCFILSSRSGGLGINLTGADTVIFYDLDWNPAMDKQCTDRAHRIGQTRDVHIYRFVSEHTIESNILRKANQKQMLDDVVIQEGDFTTDYMARMSYRDMLDTGDGEGEQDEAGRAMDRVLGTAGDKNIVVLEQAEDQEDRAAAKVAAKEIQVTDDADFEDQATRATPQTGEARNTPAPSTGLGFGGNGLFTGTDSAPTEMVEQSEKWHHIDEYLIQLQRYLMKDVPLEGGANSKKGKRGRRRDEHRVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6G7</accession>
    <name>A0A1C1C6G7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-repressible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6G7"/>
    <dbReference type="STRING" id="86049.A0A1C1C6G7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00743"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01046"/>
    <dbReference type="OrthoDB" id="10039103at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020100">
        <property type="entry name" value="Glc-repressible_Grg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789:SF1">
        <property type="entry name" value="GLUCOSE-REPRESSIBLE GENE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789">
        <property type="entry name" value="REPRESSIBLE PROTEIN GRG1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11034">
        <property type="entry name" value="Grg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="71" mass="7508" checksum="DD68E32F3901769D" modified="2016-11-02" version="1">MDSIKNTVNYVKESVSGAGSTASKEANKNVAKDGNAPLDTRAQAGFDAIGDKIDEQGHNRKADVHKEAAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6K1</accession>
    <name>A0A1C1C6K1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter, AAAP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_00629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6K1"/>
    <dbReference type="STRING" id="86049.A0A1C1C6K1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00629"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01100"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF461">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="9"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="382" mass="41245" checksum="92AC708B5930909D" modified="2016-11-02" version="1">MSLTHDCKGIFALYTSLVLIDFKLNHPEVHNMGDAGKILGGPILREILAAGTVIFAVCATGSQLLAGQITLGVLSDNKLCLMWYTGIFAIPTLILSFPRTLDQLSWLCIPSCICILVAGIVGMAAAGANPAPDRHVDVARSASFYDAFVSITNPVFSYAGHFMFFILISEMKRPQDAKKAAWVLQVFATTFYAVFAIVMYVYLGPSVSSPAFSSLPTKWAKATYGIALPNFLIAGSLYSHTAAKLFFIRLFRKTRHLHQHTVLGWGTWTALIILANGAAFVLAVGVPIFAYLVSIAASLFASWYTYGIAGAFWLYDAWHGLDKGRIRGTYGLRAWTGSPVKTAVNMATFLAGAFICVAGTYVSVKLIVDAYDSGAVGEPFAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6V0</accession>
    <name>A0A1C1C6V0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EB1 microtubule-associated family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_00724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6V0"/>
    <dbReference type="STRING" id="86049.A0A1C1C6V0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00724"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01123"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1430:FF:000005">
        <property type="entry name" value="Eb1, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB1 C-terminal" evidence="8">
        <location>
            <begin position="68"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="159" mass="17569" checksum="F076B5421D42E901" modified="2016-11-02" version="1">MQDNLEFLQWSKRYWDQYFPGHEYDAVARRKAAGAPAATPAAAPRASTGSSTTRRTGTTPVNRPAPRASGTATVGSAALKIENDQLKEAISGLEKERDFYFSKLRDIELLLQTACEQDPSLEKDENGLIKNIQTILYSTEEGFEIPDLEANGAEEPETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C705</accession>
    <name>A0A1C1C705_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AvaB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_00560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C705"/>
    <dbReference type="STRING" id="86049.A0A1C1C705"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00560"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01169"/>
    <dbReference type="eggNOG" id="KOG2063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="18"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="706"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="843"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="996" mass="110658" checksum="8416CBDA1B37E96A" modified="2016-11-02" version="1">MLSAFTAQPIVELKQRDKSKIESVLFHSDQLLVGLNTGALRIYRIKGPPSRPDETSDQDGESGSVAHTPATPSKPTELLREYEKFAKYKIEQLAVFREANILISLSNGLVSIHDLGTYELNEQLTRSKGASTFAATSNIVKDSSTGVPTLVSRLAVAVKRRLLLWTWHEGELEGDAVEIALSNSIKSLTWATGTKIVVGLTANYVIVDIDSHEVKDIVGPGSIGGTPGQESSRLGGTMSYIGMGSMVPTPLATGLGENEMLLAKDINTHFIDRNGNPIGRRQIPWRVPPSAIGYSYPFLLALQEASKGVLEVRNPQTLTLLQSIDLPGAVLLQVPNPNISLAHQGKGFLVASERIIWRMQGLNYDAQIDALVDGDQLDEAISLLDMIEETLINNKGGRLREIKMQKAQHLFDEKKFRDALDLFGEVSAPPERVIKLYPPVIAGDLATDEGRATPETEETPKNEESPRKIARKSDSVPSPVKKTKTAVSDADTASVRSTKTAENTGNEGLSEKELKTAVRELQSFLADVRRRLQRFFNPDQTVRSLSEVQSAAQSEDIRQITEYLLGLSSLDDVDLADKLLEVARFVDTTLFRAHMYATPSLAGSLFRISNFCDPEVVMAKLEETGRYNDLIEFLYGKRLHRQALERLQKFGQAEKTEEVDPQLRGPARTIAYLQNLGPDLIDMILEFAKWPLETDPEVAMELFLADTENAESLPREKVLAFLETISKELALRYLEHVVDELDDQTPELHQRLVTLYLEDLTDPSLPNRDQHLDKFLTLLRTSDQYSPAKTLGLLPRDDPTFYEARAIVFSQMGNHKQALEIYVFKLRDPAKAEEYCNQTHLEETGKGAAKTSARRRSSTTDPTDEEPSIYHILLNLYLNPPKGEKALFGPAIELMARHGPRLPANSTLELIPEDLLVKEFEAYFRGRIRNANSIMNESMIVSGLRKVDAVRVQAALLLGEGVQSGGRGRKVRIDEDRVCGVCYKRLGSSVISVFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C737</accession>
    <name>A0A1C1C737_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C737"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05796"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06977"/>
    <dbReference type="eggNOG" id="ENOG502SKDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5086080at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF7">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="51542" checksum="4465BD55AE8906C9" modified="2016-11-02" version="1">MEAPTPKPTKSRRRDADDSRVERKRIQDRLAQRATRERTKNRIAYLEQRLSSLEAGDKHGEITNLTRIIDNLRNDNNRLRNALVKMRTVIDQAVLPTEDQVEGQSAVKACGCSTQAKCICQQGTFAASPSVTLEDAAPAFRHTSVSSTGTSEVIEVVNGANVGLDPGMEAPDEVQADTLHEFLDFSPNTLLEMFEFGPPSGYNGWQSPAPSPFDYRFPSSYDTVRVAPDLEKWEVSNGAFINCLDCVKRRTATTSTLDMHVPFKAVIWGWNNVGPEANHPIWSSLRQVDQRVFGTWTSKAQRIALMYVCQTLIQWREDPTKENLERVPVFLRPRPSQEKIQHPAVIDFLIWPGLRDRLVFEYQKYTSTGDFSAAFVENFNFHWPYPDRDIFAYNQVQNRYEVSKTFLEYAYNFKNWTMRPGFFKKFPEMQHDIAAFDPSSMECPKESWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7C3</accession>
    <name>A0A1C1C7C3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7C3"/>
    <dbReference type="STRING" id="86049.A0A1C1C7C3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06443"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07064"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802:SF1">
        <property type="entry name" value="IP11341P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13250" checksum="0AACCF7F6C3A282A" modified="2016-11-02" version="1">MPPPPHPPLQVPDSYKSLPLKQIKVSYVPDSSPTPTPVLLITLNRPQKHNAFTDQMREDLERVYELIDIDPRVKVVVVTGAGRSFCAGADLEIGFLGSKDETGQIKHPKTERDVDHRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7P4</accession>
    <name>A0A1C1C7P4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dicer-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">dcl1</name>
        <name evidence="21" type="ORF">CLCR_05352</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7P4"/>
    <dbReference type="STRING" id="86049.A0A1C1C7P4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05352"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07197"/>
    <dbReference type="eggNOG" id="KOG0701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18802">
        <property type="entry name" value="SF2_C_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056755">
        <property type="entry name" value="DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF62">
        <property type="entry name" value="DICER-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24995">
        <property type="entry name" value="DSRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="92"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="412"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="20">
        <location>
            <begin position="597"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="17">
        <location>
            <begin position="1073"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="17">
        <location>
            <begin position="1243"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1446"/>
            <end position="1467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OCT44516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1553" mass="175391" checksum="C365E12BDBA2672C" modified="2016-11-02" version="1">MAINDSTAKVADRFEVNLGQRDEEYLTESEDESGSQLLSSASQVDFDVNKATLNNYIIAHANDGVKLEAARETKNGESNRIIDQAREYQQELFDKAKDENIIAVLDTGSGKTLIAALLIRHYLQQEIITRNQGEAAKIVFFLVNSVHLARQQARFLSNNLPQKVIPLFGDTSDDLWKKAEWSKIFAENSVVVCTAAVLDSCLMHSFLKIGQISLLVFDEAHHCKKNHPYSRIIRDYYLKWKGDRPRIFGMTASPVDSKRDIAKVVSDLEALLQSKIVTTTDLSIYEFAPRAKDVMWVYPPLDGEYRTSLCSTLEPLCGFVKDLAHYFTFSRFASKHLGGWAADRIWKYALPTSEHQSAAIVRKYERSVAYMEITDPDQRQAKMKLIREAVSVVHRYTFRPPQVDVDRELSPKVTKLYEELKDRYLAGPTTRSIVFVEERLTAMILCDLFESVALPHLRPGVLVGVSQSGIEAGSWRDQETVMEKFRTGVINIIFATSVAEEGIDIPQCNLVIRFDLYKTPIQYMQSRGRARMKDSVFVHMVEEGNFLQEAGVNFAMQQDEYIREYCRQLPPDRLLGQGSKLKQLMARDASCHSFVTSAGVLANYANSLLLLKRYTESLKKIGAASSEIYDELIGAEENMFQYKVILPPTDDPRTAGVKGAKGEPRTNKALAKRSAAWHCIYKLRKAHLLDENLDSIFSKVKPANLNARIAVSERKDEYDKKVKPDFWVHSGTTSPILPTELFVTHIRVEPESSSWSSDGVLLFTRAKLPAIPRFSVYVDNNVEKHVTFYQYADPVVVTTDQVEALTTYTLNGIFYDIFNKQYSHNSTSMSYWLAPPGQPGQSRAFENVVYMNQLLAAGAPERGKWNPSTSSSDARKWCNAFLVDRGSGKFRYFTGEILPGKTIFDATPDSAKSLNKKYDKTIIEFSDSTWRAKSKDFEKEVKDGYDAHQPVLDAKAVIAGRKYTEKCPEKEQRYAFCHIAPQPLELGRISYSVAQTCILWPSILHRLEGYLIVREAFQKLDLAHVPLDLALEAYTQNPSAEAEIAGFGSDAGGQHWPEGEGLPETSKETGAMNYERLEFIGDSLLKLMTTITVYNRTTCNEEGMHCKRMNLLSNSRLCETASAPHYELYRYIRSTGESWRDTWYPEFLEQVGKGRIIKLTDKHRKHALGKKTIADVCEATIGACIMTSQHLPTEEKFDLGIKAITKLVEHPDHAINSWKEVLPMYKPAAWVGELNDPIANDYADKIFAVTGYRFKHPRLIRSAMTHSSDQHSPVQDLQRLEFLGDACLDWVCIWWLFSTNPTRDPQWLTEHKMAMVSNKFLAALAVILGFNKFVYATSTAVYDEIGSYASKVQEAWADGNVKPDFWTRVVTGSNVPKVLADLVESYLGAVLVDSNFDFREIEKFFEKHVKWHFENIEAYDTFANRHPITHLVRLLTQEFGCRQAVPVPTEGSVPPTTHAEGGEDGDVDVDGGDVAMTGVECHLGWMVHGEIVTIGKGHSVKYAKVRASKAALKILGKLTVDEFRKQWKCDCRTEKRKASVGSVKSNTNYQSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7R7</accession>
    <name>A0A1C1C7R7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">toa2</name>
        <name evidence="12" type="ORF">CLCR_06380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">TFIIA is a heterodimer composed of the large TOA1 and the small TOA2 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7R7"/>
    <dbReference type="STRING" id="86049.A0A1C1C7R7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06380"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07190"/>
    <dbReference type="eggNOG" id="KOG3463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.190:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000003">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="11">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT44508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="114" mass="12936" checksum="10A7997286C783A7" modified="2016-11-02" version="1">MAAQQYYELYRGSSIGDALIDTIDDLINEGRIEPQLAMKILSNFDRAIAETLAEKVKSRLTFKSLQGHLETYRFCDDVWTFLVKDVRFKSDGGQEFHADKVKIVSCNSKKPGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8K6</accession>
    <name>A0A1C1C8K6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_05555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8K6"/>
    <dbReference type="STRING" id="86049.A0A1C1C8K6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05555"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07508"/>
    <dbReference type="eggNOG" id="ENOG502RB10">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="265"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="640" mass="70581" checksum="F2051C6C4FD6AB42" modified="2016-11-02" version="1">MDQDKKGIPHQRKRPRYLSTGGGPETPTSTPQTADYVTLTSEEAVSPAPREPQRGEASTRIFQNAAEIGSLGQFSFNLRSEPADTQRASDGFVGDAQDAAPQSPVYVVATVESHVGQSDYIGAGEVRFREEMGQAQSPASGLSDTDLRLLQVQKAFDLPQRSVLASLIDCYFEYCSGWVPILEPAAVEEVQSTGSSPLLLNALLLAGSRVTSNDLLAALAEDFYRKARLLFILGHERDALNSIIAVTLLQWYNPTGPERISTSTSGFWVRISAGLAYQTGLHKEPVAAKDRGLRRRLWWAIVARDDIISVGTGRPRTINLDDSDVAPPTIHDFPASDGKARLFVVFSGIIRLLGDLTENIRRKTVTATKRANLENALYRWVKDLAPSFRLFHPSSQKLNPYSFEARQLLVPYFVTLFILARHSPGQDKTLRVSFIASSFVVGIFEDFLNRGELCHCGPVFSFYAFAAGLAQMPALRYRTLAQSATESFSIIQSSLAELMKRWGSAEGALAVLVEMNKLTLQRPTLGDAPSQGSTDFAPFFDDFGPELCRHYWLLERPGQIVNAPPSLPSCFGQADVSEPRLDREMDDSVDRLRPQTSVDPSVLNTEHADPMLMSQNPIFFDDLDPSGRWIDDLGLGLATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9G9</accession>
    <name>A0A1C1C9G9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9G9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05358"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07761"/>
    <dbReference type="eggNOG" id="ENOG502S984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5371510at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="677"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1247"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1259"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1286"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1355"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1368" mass="150312" checksum="19DE0C57C173E48B" modified="2016-11-02" version="1">MDLPHPDPKHTDVWPATPANPSWNEASNVTASTSATSQRILNEHADLAEAIRLSLEHRQNSLLQKRLPVEGDSSGLPLELVLGLNNEFDPLDQPEDDVAIYFGAPPQEVGQTDQDYQYIKHHFDRVHALNWRTLRLMGDESRFTDNDLLNPTKSFRAERRLRKEHRIVLERAERKHGGKFRCYIDLRPPKEDEEAVILITELSCTRGVLTWHQARDRYNLAPLSVLGHDDFGGQPPAQAAGQQANPSGTVEETPADSTTSPPNLLELARKLVKAPTSLAPNSQPAVAAEYSALRHHSALERLLQAISGKDPKLDSAPKVWTFFALARYFGCAAHERIARWITTWLYADNNANFIQNNPEVAYRIAMGIKSPNLIKVSFSILVGERALIEAYGEQRSDILTPLRQNVHGRKLELLDDDERNRIDHAASSLVKRIRDITSHMCEHLTFLRESSMYDVLDKTIAETPEETSLLLSAKKTIHEYVRSRIYYVLCQDQKPFEELEQDVKSTLRFRSATANSFSEVYNTLNPSTRPFTKTFWLALQHTQFDIGHTNIAAKGTTSFFYDTDHTLEFKALYQKQPVYGITQILRSTFDDKIIEVNRMLRERELAKSRRLNGMEHPVSDMSPGVMHYPTDLALDKLAIKTPPGSPLSRRAEEGSSPTKRRKTTKTEKFVDGFWDTGSSAPSSSNPGPTKKVAFPASPSNLGSASAAELGGGSDLFLSSPDRATAPAVSEECRGMSSARKSTYGNPASPTPSLPSIDGRLASQVEKAPTVPSKSQPTLALRQKAMRMDASGPVQRGMEDQRLEEQQPTVEHIQPGPTQATAWTEKVAAFLAKHKSHKHNSTLPSHPEAKPMAMNTNEELIPPELPPLASFSESEAGGGIGNGPNSSSSPPVATKELPSSEAGELPVNPTPQTAGSFPYSQASFNGSHKFMPVPQQPLQLTSGSSSRAVQQAFSNSNTHRQTKYLSGHCNATPSAELRKQALYPINPQEMLHEIGAAVGEICSGVLYPPHLFHHTGLLPTNLVDTVLNLGEDEFRYLPLWVPGGNDDGSGGVFDETPVPNIDPARVTFESFGPGRIRRPYDQADSPISDSDIEEISSSQGISTVGKASKLATDGTHTVTSLSSDTSSANGRPDADVVVVDPARDPWGAVDVGEGIPSRNAANGSEMTDPDTGLGFCETGDDANEADINNDNNDIDIDTINGDDPLEREMTASLRAFVAGGDDDADSASNEPYEGNDTSDPDALDIKPAAHPALFHSAAAAEEEEEEEEEEEEEEEEEEEEEEEEEKQAEVKAEGTGEGKETGKAKAQNHPFLLPNRHDDDDDDEIQHHAQIQTTHSAQSAQLTSNVRHGAMPHSQDEDEDEDEDEYEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9H3</accession>
    <name>A0A1C1C9H3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_05652</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9H3"/>
    <dbReference type="STRING" id="86049.A0A1C1C9H3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05652"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07778"/>
    <dbReference type="eggNOG" id="KOG2493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF57">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT45111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="608" mass="65525" checksum="54B8203A8D7F6085" modified="2016-11-02" version="1">MAVLSEYNYVFAIGTLFALLDAYNNGANDVANSWATSVSSRSVTYQQAMVLGAVFEMLGAITVGARTASTIKNKIIPVDAFQDNAGVQMLAFTCALAGASMWVMWCTRHSAHVSSSYSLISAVAGVGVATAGAAQVQWGWNDGQGLGAIFAGLGLAPLISGGFAATIFMLIKVIVHLRKNPMPWAVYTSPFFFLVAGTICTLSVVYKGSPNLGLNKKPAWYIASVTLGVGGGLFLLSAIFFVPWLYAKTIKKDHTIRFWHLPLGPMLWKRPPPAEVHEHANVPDYAVIQKDQDDESTHSSEVGVKVESDATKVPVQAAQEKSSHDRSLAEAEAATPQLTYKERVAEAQERFHAKLRKKSGPLGWAMRMLHNNPLAPGEIYELKNIKIILKRIPAMITVAALYGVNYDIHAAQTGIHGTPEGRRMERVYAHATKYPNEVEHTYSYIQVLTACTASFAHGANDIGNAVGPWAVIYSAWKTGDAAQSSAEVPVWQLAVLSATLSCGLITYGYNIMKVMGNKITYHSPSRGSSMEMGAAITVLLFSQYKLPVSTSMCITGATIGVGLCNGTWRAVNWQRVGLLGFSWIMTIPVAGTLAGCIMGVVLNAPHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9Q1</accession>
    <name>A0A1C1C9Q1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_05686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9Q1"/>
    <dbReference type="STRING" id="86049.A0A1C1C9Q1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05686"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07846"/>
    <dbReference type="OrthoDB" id="4835445at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="600" mass="66917" checksum="A406F4094E24F8AB" modified="2016-11-02" version="1">MAKKTNSVEPCEIVDDKTQVSRADGRHDSLLQSPPPLSDVNAFPIDIFQVNFLDGLPDRALVDEGTLDFQWSTMGLLEVDDLSPKSHQISHANDVSTDQLPSPTFDRVHQPTRFDALAAPETLSHTRPGTKAEQLCLASSKPRQEDDLPSPGRPLNDLGSMLVEYYFKEVAGLFSCYDSPLNPFRTSVSRLWRSSAAVMYTVQSMAAACLTDVCPTLRSTGFRMREKAAACVEADMRLSKVDTGTFLVLIMLGLSASWHQPNDLGRKEFEKACTIVDAIHAGGIPKIQEDSNGRNLQFFHEAMIYWEMLMSYVSDITMPPSQSLSLQTMQSEQDYSDIGQPSFPHPWTGVAREAQSIVFEIGRLVRRERLRLRNPPFFTSVADLDTGQKAFNTAVILAYRLLNLKLPTEATIVNPGDAQTPVRHLLTIGEAYRLAGLLQLYRVFPDISQGPDNEGQCETRSGRSPCISDQSRNLSRMALEITGLLRTIPIESRTRCVQPFLLVAAASELRPEAYEEVSPPSEHHNSAPDDASALATAIEVLEARKFVIGRLSTFEHVLPAKPIRQMMEIVKHTWDRMDMGQANVYWMDVMIEKGWETTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA62</accession>
    <name>A0A1C1CA62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_05903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA62"/>
    <dbReference type="STRING" id="86049.A0A1C1CA62"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05903"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07991"/>
    <dbReference type="eggNOG" id="KOG0113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="104"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT45357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="423" mass="47129" checksum="C0077E5D7352934B" modified="2016-11-02" version="1">MTDKLPPNLLALFQPRPPLRYIPPQDSAPEERAVKKSQLSGIAAFLPQLDDYKENDVYKPTESWLQKRDRKRYEKKLRQAEIEKPDFQAYRPNDDPKIKGDAVKTLFVGRLSYEVKEADLEREFGRFGPIERIRIVKDETTPKPKKPHKGYAFIVYEREKDMRGTFFYASPSALDPFTHHPDDMPHTKKQMACASKTEKSSWMWNVVAWSLDGDLKDSAAAWVEEDIPSKLLQDLRMAPLKVDMGMASEVASEVVVGSAADSVATSVATVEVLVAEEGWAIKEEAVSVDAADIKADLHRPTHPAALVEEAAMAEAMRTDEMVTEAEGPPEATTTLSAAVTEDMRTETETEIEIEIETRTVTDMVAADATMTMAPENDTTRTTGMMTPDNAGGTKHAHSISCVTHTRHLVQLTVGWVGILFTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA74</accession>
    <name>A0A1C1CA74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-oxosteroid 1-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">kstD</name>
        <name evidence="6" type="ORF">CLCR_11199</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA74"/>
    <dbReference type="STRING" id="86049.A0A1C1CA74"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11199"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08061"/>
    <dbReference type="eggNOG" id="KOG2404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF10">
        <property type="entry name" value="3-OXOSTEROID 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="5">
        <location>
            <begin position="80"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT45433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="641" mass="68531" checksum="74696EBFEC30688A" modified="2016-11-02" version="1">MASISGRPWMLMRFTRTLAFGRATRITASRRSVFLKRTLTTTTAWRYAELDTATGASAEAGIQTLGGDGKNQPVVNEACDLLVVGSGGAGMSAALTAQHLGLKVIVAEKEEQYGGATARSGGWLWVPGSSMAEAAGIRDSVDQALTYIRHEAGPYFDEARAKAYVETAPEMLDFVVKNTPVRFELFTGMPDYHPNSPGASPGGRCVFTKAWNSRPMGDELSRLRRPLQSMTAFGMQIGNEDLATFVTAGRKFSSFFRVMQLLAGNTVDRLRGRPPSRITSGRALIGGLAQAATSRGTQTWTNTPVRRLMVENGRVTGALLERNGRNIQLRARRGVILATGGFAHDAQLRNQLLEGSMTDVGTNQAAWGLLPFGVTGDGIRMAKAAGGRFDDKVTEPIAYSPVTRIFNAEGDLSLFPVFVGRAKPGQICVTRSGRRFISEGCNYHAWGEALVKATKGEEETAAWFVCDKPSLQRYGMAAVPPWPIPFGHLIRSGYLKQGNTLRELAEKAGIDPDGLEDTVDHFNAHAREGRDPEFARGENAYDLANGDLDRQPNPCLGPLDQGPFFAIKATAGCGSTHAGLSTDANACVLRSDGSVVAGLYAVGNDAVAITGGKIIAGGITIGPAMTFGYLAAHHAARSTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAB9</accession>
    <name>A0A1C1CAB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAB9"/>
    <dbReference type="STRING" id="86049.A0A1C1CAB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01487"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03401"/>
    <dbReference type="eggNOG" id="KOG4498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="610" mass="66646" checksum="F4937B7FE82E7240" modified="2016-11-02" version="1">MSVEVPPDNHALRVAFEHDIYSSSGKPLKFGSLFYDCDVYPAEKRILVIFIRHFFCGNCQEYVRRLSSAQSPFHPSLKSTSTTWTTNFSKPANRTLPSIIIIGPGQPSLISSYKSLTQCPFDIYADPSTQLYDILGMHRTLSMGTKAPGYIEHSLLGGAVKSAWQIVRRFGSGDALAGGDWDVNGGEFLFTRPAMGSRSESHSPSRSRSRSRSTNSRVSSNMNWTLTWCHRMLNSRDHTELIDLAYHTCFSTQSSLENSSRTQSPAPPLKSILVSGNKTHTKTLSHSYSSERLGACPAPNIPKSRAEALASPHHNRPGSRSKARPRSRSTSVSSAQTAKQNHDRIWSSMSSSDTLRSESRASTTTNRENLAVSPISEAEEEEIKPRKSFSASVAEAFGVRTTLLKRSKSVSGSSTAPEGAPALPRPLTSLPVGLRPASRAGSNMTKARSKSIIDPIPLLRHKPRASNHSDAEASQEPTTSPSRPRSPSATGTHTRTRTFSFSKTASKRRPSLSLTRKPSNRVGMDENGVMLVNGVEFVNVISVKARIESSAEDEQSRKRLRDRADSGLGMDVTQDKNTPAVGTRALKELPPLPLVRPSHRKNDSAAPALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAM1</accession>
    <name>A0A1C1CAM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2 type zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_01425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAM1"/>
    <dbReference type="STRING" id="86049.A0A1C1CAM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01425"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03476"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT45565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="847" mass="93557" checksum="6A3BF1B939FF8CCE" modified="2016-11-02" version="1">MPSKGLRDRKCLFCERKFVKAEHLHRHQRAHTGEKPFKCSYCGREYGRSDVLMRHVRNHHSDDGQQSTLRPVASGLGEGATAGTKALDAPSSPYDVPPACLMQTPLSGEDTQHQEGTATQARSNDPALQVVAYPPDSGGPVDRRVADPFDAIHSWLEPPDLSLGLNIWDDLPQFVFGSIAGGSTLGLSTSHSRVLVRSPPTDDISDERYAKIASLWPMKKQTPRRLIQTLWRDVSSYPEDNIFSQPMEVVDEESLSSRTPSRKGESRWGLDEARRLRLIEDCAPLHTQPRSRRKSTGDAAIRDHSSAAENASVDSCGSAKFPSTQILDISLDIYFRRFHHLMPFIHEPTFAARQTSSSLLFPMCLMGLTLLDSVRAKRFVSAQLVDAIERCRRDLVLSSRHGGQMGELLTALAAASLLLTVACISPKQALAEHSRLLYSEAITVAQRHGLFFPQEGQELSSTIFSTLDGDTAKWKAWTKIESVKRLIVCLIMSDSFFSALDDHNPIIQTEALHFYFPCKNELFQAPTAKRWIQLVNAGAATVMPWMTPQLETAVLPPPADANTLGFFGLFSTVWVRIAEAKHRHTSLTSNASGLLIPADVFAHDEHAASIVPLLLKVWSTYGPTMGSINPNCEAFWHHLNISMTADLGLFELASGREGAESAKGALDAIATWSQTSAARRACVHAAQTFLIMSKRRPIDGTSYEAEIALVHAALVLGLYVFVMPQDDPDTRARALEDKHAEPFELLDNVGWNLVAEEGFNSYTTNRPETDVLLSSAMCPARDFIRAGGPISFSGVVQHGGYASARRILLDYVYLLEENGTRYNVMEFCHILRILSDALIDLDSTGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAN0</accession>
    <name>A0A1C1CAN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nonribosomal peptide synthetase 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01498"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03438"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="589" mass="64734" checksum="708E0BEF80934306" modified="2016-11-02" version="1">MTQGGCFIDSFPQSPDGSLPVGLDVVYTSPSTVGVSFAPSGHCKRASSRLLLMLLSRSSSMTASAIPPLPTLESQQLHIRLDHGDDTVVTNDRGLQSELSDIPNYCISQIDGERPTTSSAADSDLAQHNTTVAQDQGSSRSGSLILEKNPLPGMQMPDKKYTRLLRNLRWTIFSVYRRLNALVLTANIIAIIVLAAQHKLVSMSPERAASAVSINLTVSVLMRQELVINTLFWVFGKCPQWFPLRIRRLSAKIYHLGGVHSGAAMSATVWFAFFNVSIVNSFQSGGIRRHQSSIPIITVLLDVLLLSIIAMAHPAIRARMHNQFELVHRFAGWTSVALFWVEFALLTDAKVHDVYSPEPASVAVLRSPVFWTLLIATISIALPWVWLRKVKVNAEHLSDHAIRLHFTHTKLPLCAAPRISDNPLLEWHAFAGIPDEDGQGFSVLVSKAGDWTSRLIRAPPTALWVRGIPTLGVLHVAPIFRKLVLVATGSGIGPILSLLSQSDVRCRILWSTPTPEVTYSKNVVDTVLRADPEAMIINTTVSGRPDLVKHTYELYVKSGAEAVFVISNPRVTRRVVYSLESRGIPVFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB90</accession>
    <name>A0A1C1CB90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TRA1</name>
        <name evidence="8" type="ORF">CLCR_01374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86049.A0A1C1CB90"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01374"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03640"/>
    <dbReference type="eggNOG" id="KOG0889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="6">
        <location>
            <begin position="2622"/>
            <end position="3177"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="3421"/>
            <end position="3759"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="7">
        <location>
            <begin position="3802"/>
            <end position="3834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2000"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3185"/>
            <end position="3250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3763"/>
            <end position="3796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2000"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3185"/>
            <end position="3203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3207"/>
            <end position="3219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3237"/>
            <end position="3250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="3771"/>
            <end position="3796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="3834" mass="436090" checksum="B2B5674E477AE456" modified="2016-11-02" version="1">MDASQKIDLYATRLNTKTKSNIATDLRDSLESLCSPPPVYTKFLTKFWPVFKKILEGKPDFHPTSFEHILRNQILEVLHRLQHAPPEVEPFALDMVETLMELVRVENEDNAVLCLKTIMDLERHQPSATASKVQPFLDLIQEMFQLMEQVVHDTFDSPAPHQTSSSGSNPQSQTFQSPRPASPATTVSDPGAEKREHAPLAKGMQSFKVLSECPIIVVSIFQAHRSTVAANVKKFVPSIKGILLLQAKAQEKAHAEAAANKTIFTGVSKEIKNRAAFGDFITAQVKTMSFLAYLLRVYANQLTDFLPTLPSVVVRLLKDCPREKSGARKELLVAIRHIINFNYRKIFLNKIDELLDERILIGDGLTVYETMRPLAYSMLADLIHHVRDSLDRNQIRRTIEVYTKNLHDSFPGTSFQTMSAKLLLNMAESITKLDNKEEARYFLIMILDAIGDKFAAMNYQYENALKLSKQYGEKPNEQQSETYMDEKDQRPDWDKVDIFSATPIKTSNPRERGADPVNDNKFLFKNLVNGLKNMFYQLKTCNPPGLNVDQASIPMNWSEVSFGYNAEETRVITKLFHEGARVFRYYGADNPVPDMQYSSPVDFMASHSMAQMTREEKELLESFGTVFHCIDPATFHEVFQAEIPYLHELMFEHTALLHLPQFFLASEATSPAFAGMVLQYLMNKLPEVGSSKIVQSSILLRMFKLSFMAVTLFSAHNEQVLLPHITKIITQCVQLAVTAEKPIHYFILLRSLFRSIGGGRFELLYKEILPLLEMLLETFNHLLQGARDPHDRDLYVELTLTVPARLSHLLPHLNHLMRPLVVALRAGPDLVGQGLRTLELCVDNLTADYLDPIMAPIMDELMTALFEHLKPQPYQHFHSHTTMRILGKLGGRNRKFLNHPHQLSYRRYTDDEPSFDIRLKETARDRAFPLDTGVDLAIRKLTEVSKTTSAKTPDPYYKQQSFKYISNQVKLFVGYDNLPDDFAALLRLQANDLLARRFTTYADMLAENEFGKSVQKRREQEENLKKLLKACFTATTVPELKAQAEAFISNVSRHFAIVELGQALCDAGRRTKEFDVNAGEGAVHLSTRLLADVICDCLASENVFVREAAEASMTSVLDTARTICGSDEKAAKLPFFTHLTQTFCHRCREVEWFTKEGATLGIQIIVTKMNLGNAFLNSKQLEIIKALLFVIKDTPQEVPASTRITAQKTLEFILRKCCAGQTKEMLTNERSTIHALSVTFSLELSHMNTHARETAQHAFATMAEVVGVDVHELITPVKDRFLPPIFNKPLRALPFLSQTGFIDAITYCLGLGHDLVPLNDQLNRLMMESLALADADSEILHPKPDEYNNAQLIVNLRVSCLKLLSIAMSLPEFAAGPQNSSRARIITVFFKLLYSKSPEIIEASNAGLKEVLVQTSKLPKDLLQNGLRPILMNLQDSKRLTVAGLEGLARLLTLLTNYFKVEIGARLLEHMRVIADEQLLQKVSFGLIEQNPQMKIVTAIFNIFHLLPAAATSFMGDLVNSVLDLEGKLRRTVASPFRQPLVMYLDKYPKETWSFFQSRLQEEKYGRFFGQILSSDASPAIREAVMDDTEAFIKAAFDVENAQERHTAAINGIYIVHSICAMDSEKKWLRNQEQLRSKILAAGRELEEQLRKDKLQSSQRLRAEQSGDQLMDILTQYLTSAPDDLSFMMELFSSAAQGTVKTPLKLTKYLFESVICDQSTTRRYDIIEKCLDIYSQKSEPQKVKTFLLRNVVNPIMARDVQNTRSEDNTAGTLADSKLFNLFLERLWKPAAADVVDDPSQPGVDHSRMEALQLSAFILKYHKDAVSEDRKDIIKYSWGHIKLEDVINKYAAYVLICYFIRSYDTPMKIAVQIYNQLLKAHQNEGKALVTQALEVLAPVLPARIGASANTPGEKRSPSWARLPRKILNEETGNLQQVQSIFHFIVRQPDLFYDSREFFIPTIIQMLHKIAPPPNPSNENKKLALALISLIQQWESRRVSAVSPSQSTVELTPSRKRDSTGEQKLAPPPAREKAEYVIPLELRTAVVKYMITFITSVPERYPMPSAELKSKTMQKVQQQPMSNDLCQKGVQLLRELLAPNLWTDIDVGLYEKLLDPILSGEKADKVDEKQLTCMINALQVMRILLNVKSNDWIINNMEKIQKLLEKPLKMEEPEIQDCLHLTTDDDTSPPLVRRVLDAIPTVKADDADGMDLDVSPSDFPTRYSKVLIGEALSNGNYISGINNLWTLSLVRPSDVDEHINGAMKALQHKLAKEHINAYVIPPGPPPQGWRLGEPLMDPYEFALGVDLIKKTIDILSSRMGELNEQRRPFLSVLASLVEKSFNVEMCSKVLDMVEKWVFNSTEPWPTLKEKTAVLHKMLIFEKWPNQTLLERFLDLVIKIYEDPTVTRTELTVRLEHAFLIGTRAKDVDMRDRFMSIFDRALSKTASYRLNYVLTLQNWDTLADSFWLKQASHLIMGSVEMSMPARLHPEDVRMCPMSQLFGPGLVNPEQGKDDLIIEDNLETLVSAQRRFNQEIYEVKVRDLLEPLTQLQHTDDNVAYDVWVKLFPLCWSALTRDERLDLEKGMVTLLTREYHQRQLNLRPNVVQALLEGAVRARPRFKVPPHVMKFLSRTYDAWYTALISLEESTIDPLIDTPAVRESNLDALIEVYAGLQEEDLFYGTWRRRCKFMETNAALSYEQHGIWDKAQQLWESAQVKARTGVVPFSQGEYYLWEDHWMICAQKLQQWDILGEFAKHENFSDLLLESAWRNYEAWSGDENRNQLDSMIKSVSDAPTPRRTFFQAFMALLRYNSKQVSRAEFQHVCDEAIQLSIRKWHQLPKRITNAHIPILQQFQQLVELHDASVICDSLMGTNERNLDNKSQEVKLLLQAWRDRLPNIWDDINAWQDLVTWRQHVFQLVNTTYLPLLPQGGNNVGNNSYAFRGYHETAWIINKFAHVARKHQMPEVCINQLGKIYTLPNIEIQEAFLKLREQAKCHYQNKAELNNGLDVINNTNLNYFGAQQKAEFYTLKGMFLAKLQHAEEANEAFGVALYYDLRLPKAWAEWGQYSDRKFKETPTNIEAASNAVSCYLEAAGLYKSAKSRKMLSRVLWLLSLDDEEGHIAKAFEDFKGETPVWYWTTFVPQLLGSLEHKEARLAKSVLVKIAKAFPQALFYHLRATREDFLGKKKQFEAQRAKQQKPQDDKKEGSSRPGTANGETAANGTASPKPKQEDGDASQANGIDAEKKPEEPKKPWDCTDEIMAGLKTAFPLLALSMETMTDQLSKHFKCPPDEDAHRLIVALLNDGLHYISRAPMTYAEGAKLPPQTEANVARFVQSVLPAHIRKSFEADFVQTKPTMYEYIHKLRKWRDKFEQKLDNRQQWAPLESYSHHLSEFKFLKFDDSVEVPGQYQQHKDKNTDFVRIERFMPTVELVRGNSICHRRLTIRGHDGSLHPFAVQHPTGGKVRREERIVQLFRIFNQTLAKRKESRRRNLYFHLPIFVPIAPHIRLVQDDASYITLQSVYEDHVRRLPPNTMSRDDPLLFVLEKSRTIAEQQKTTPRTPEQVAIMKTEIFSTIQERWVPNTIVLKYFQSTYPSFEDFWLFRRQFSYQFAATTFMTYVMHMSARYPMKFSISRANGDIWASDLLPNLNSTRALFYNPEQVPFRLSPNIQTLMGPLGVEGIFTASLMAIARCLTTADGGDGAAGSGYEMEQQLAVFVRDEMFNWAAGRPQNAQGTEQKMEGNHLRELVAMNVDFITRRALTLAKTQGTVNPSAAAGGSGAGQGGASGAGAEGLGGSSGGSTATGGTGVLPACQNVVDLISKATDPTRLSSLDGLWMPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBL0</accession>
    <name>A0A1C1CBL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_01495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBL0"/>
    <dbReference type="STRING" id="86049.A0A1C1CBL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01495"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06745"/>
    <dbReference type="OrthoDB" id="4154979at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT45857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="520" mass="57938" checksum="16443B4254165A02" modified="2016-11-02" version="1">MDGMLGKFKHVRQRQKRSFSPKVRTGCQSCKQARVKCDESKPICEKCIKRQTECHYEVPMVWISQSPATTSSKERTKRTAKHVARETQADETTTMLADDLPPSSTSLRSTPGSTSVSRRMQSPPALTASTVSRSAPLSIHHMDTLLHVVPVTYRSLTRSLPSCTDWRHLAALRYFLEVPAPKVAYSKTGSFFTTTLPQAVWTHPAILESMIALATMCASLRGTSTTAWTNQSPAFHYSKAISTVARSKPVRHVTLLVCMLLWLYEQFDNQHTRAMFHRASGAKLLAEWRTCEVGKNRTTDDYIASSIEPAFLTGFRVTAPVKLCREVMAALSLLVHTPIANHDKCTYDESVSHLRACIEDFLNGQPARVSTSKSSLIRTAFASLRTWDHQFEHYTGSAWATEGPVLLSYATTVAMLVQKRGFVSNHRDADWHRAADFLLDETASEWCGAAHRSLLEGVAPVAGEIALLFGIIREPHVSGAEYATLVIKFSSSPQRRGDYNIAQERGRRVSIPSLASYFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCT1</accession>
    <name>A0A1C1CCT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_01159</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCT1"/>
    <dbReference type="STRING" id="86049.A0A1C1CCT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01159"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09254"/>
    <dbReference type="eggNOG" id="KOG0342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17964">
        <property type="entry name" value="DEADc_MSS116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="87"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="298"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="517"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT46267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="546" mass="59772" checksum="99C15A8A045BBA26" modified="2016-11-02" version="1">MGRSRGHFARKARGDRHKPQNVDLDDGQVDVFASIPPDPPPPSIEIPQDTPRFGDLRNKNLLNPTIIDTLTNDLGFDHMMPVQAATLEYLLQGKDCLAQAKTGTGKTLAFLLPAVDTILRNRSPRLSALVLCPTRELALQIATEAKKVLQRLPQYRVATSIGGTNKVAEERTILRGCDILIATPGRLLDHLGEEEVQRMLGSLQTLVLDEADRMLDMGFLPDIKRILNYLPKQLPRQSMLFSATIDDQVQKVAHLFLNKDYEFISTIPEGEAATHERVDQYVVLTPSMSDLAPATVAVLEAELASADAFKAIVFAPTAAHADFYGHILASTGTLPSVSVLHSRMTQSKRTRTTDEFRKAANGICVATDVIARGMDFPGVSHVFQVGLPADKETYIHRLGRTARAGAEGRGILVLSELEKGFLHQLKNIKMQEYPSTLTYSIEDIEPALAAMDNKAKVYQAWLGYYKTFMKQLRVSTAELVTEANQFALRGLDCAEVPALEKSTIGKMGLKGVPGLRVVPNAPGSNNPHRRGGGEGRSGGRGAKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCU1</accession>
    <name>A0A1C1CCU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase,short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_01331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCU1"/>
    <dbReference type="STRING" id="86049.A0A1C1CCU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01331"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09244"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF33">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="189" mass="20091" checksum="23E05F76734E5F5C" modified="2016-11-02" version="1">MSEVTLPPPSVLTERLHHSKVVLVTGAASGIGFAAAQLFAQHGAKVILVDLASSRLEAAAEEIGHGCDFRACDVTKWEQQVALFDWVKHTYGPPEIVCLNAGIDPELATSENPSAKEKVVSNYLASESEPREGAGEDNSQLKQPPTTVLDVNFYGVLYGIKLAVHHFSAGKGGRVVITGSAASHMPVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD45</accession>
    <name>A0A1C1CD45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein AIM2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">AIM2</name>
        <name evidence="2" type="ORF">CLCR_01256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD45"/>
    <dbReference type="STRING" id="86049.A0A1C1CD45"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01256"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09128"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="257" mass="28844" checksum="7EBD32246283EE77" modified="2016-11-02" version="1">MTSHPPGACCYKGVKHEGTPTGEFSQLGDFEIYTKYPEDKSTEYGILIITDVIGHRFNNAQLIADQFAANGYFVMMPDLFDKDPIPLNRPGDFDIMKWLNGEYHPSKKAHLPPVVDPIIDACLIEMRTKYNVKKLGAVGYCFGGKYVVRHLRPESGKIDAGYTAHPSFVEAAELRDIKGPLAISAAETDHIFPAEKRHETEVILKELGLPYQINLYSGVEHGFAVRGDLNDRVQTYAKENAFLQAVQWFEEHLRGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD91</accession>
    <name>A0A1C1CD91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD91"/>
    <dbReference type="STRING" id="86049.A0A1C1CD91"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01306"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09075"/>
    <dbReference type="OrthoDB" id="4130410at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="206" mass="23278" checksum="A0372ED3AFA4DBA7" modified="2016-11-02" version="1">MSVMAKITIMSYIGTYYAIGSAWVLTALNYFLIGWFNGYLDHYYTDSFKIYFSIVVVFQALGTVSLAVLRYRVAGRSLIGAFLENLTWLPLLTIFLGGISIHVSQAIACHMLSINMTWGATAKEATRTSFFEEVPTILRRFKFTFLFCFLMVFGMIVLAGVGPLGHLVPHDWQIKDFTAIWPMALVVAFHFLLPLVLNPGLMQFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDA6</accession>
    <name>A0A1C1CDA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02133"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01239"/>
    <dbReference type="eggNOG" id="ENOG502S3S2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3063476at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="136" mass="14505" checksum="B37AFA1FD3E4DFD0" modified="2016-11-02" version="1">MTNETVTYGRGGAGNVTTKDAKSPAFKPQTTPTLKSHVYTTGRGGTGNMARLDSPEEARRAQDVDVPGITIPENVHHTGRGGAANLYKPTEAEQKEARAHNEKVRSESFSKDRSGLRGLAGKAKDNLVGKSNGEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDB9</accession>
    <name>A0A1C1CDB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_01788</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDB9"/>
    <dbReference type="STRING" id="86049.A0A1C1CDB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01788"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01218"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4160981at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="805"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1094"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1226"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1290" mass="144285" checksum="C43E6FEEC2680949" modified="2016-11-02" version="1">MDPVSLTVSIFASVKTAAVITNAIQAVSSSDVSTGIENLSTEFKHTFDAVQRLKILAEEPGQFEGKEGLCEEALGVVADTHKTLTELRKRIEKLQPPERSKGTWRSLQIRTRYQWSERSVQTLLLRLQERRQALSSVSDTFARVQAGTIQSHAAAIRVTTDQIRAETTQLRAQIDGINAQFREALTRLREASLPPITANHTEADDSGTSATQTVTRDTDCDSDSAVDVRTPSHSRNASQSAASKPSAPAPLLKQKNISLLLKASSGHEIQLARKRYATTKAAEVARGVTQQQDQNLRSLVRSLAAAEAATKGLTSPEIASAALALGKAYRDAGLYEDALQVYKEALTAREAIFGATNSITLNIWDSIGHVHVIQSRWSDALACYQILLEGRMQDPKAGQGHPSTLTAATSVARMQQKLGHHDEAATQCANVLSAYASQNKSQSLPALAVRMQIAEIHQAQGKLDEAVIAYTALRDQTRNVKGGERLAEQADAAIRKIQEDKPEPTTETSDEESEPGDRSGIALCTKDAELINTCRRQLEELSAVLGRSHPDTLAKMYELAVAYSSADQHRNAIGWFQEVVTGRTKVFGPDHPLTLDATHHMAASYEELGDLDKALEHYHTSLMRREAKLGDDHPQTLSSVVAISMVYSARGDNNVARDLLLRAVDGYTRRYSADHNATLSAKYKLAEVYREKALLQRSLELHREVLDRRIATLGPNNAVTLNSERAVGNVYRRMKQFDMAITHLQRVLEGREKTFRRVHSLTTSVALDLASIYWSTDRPGNAVVYYQQAFEGIQHQEPNSRTAGLVTMSNIALCYYTLGDYAQALSWYRKMLTIQESEYGLTHEETIHTAERVARCCMEIEEWVTAIELFQRVIASKQKSLSASPSEWSFNLFQLALACFKKGMYNESLAWSRRILDLEDKIRPEERLATMRRMAVILSKQAKLEESLETYQKALDECKTSLGDDHWLAESMLSEMSELYLQIDGAPFVARDYQKTLDELQRRVNKDNYKSLKILYEFADVHLDQHRYQEALSLYTTVLEAVEKSSHRHETAFTNLCNACISDIATCHMKLFNTDLALSFLDRLICCGDDEYRLGALVRIGNTQEKQGEYVAAIETYKQLLDLETAKVGANHRDPLMSVRKIAALYSRVSRYQDALTWTNRALQGFQALGTDTQAETFETLDFLSSVYCHLGRFQDATRVQKEAMEGFARVRGPQHASTLKATLDLAEMYRALERKEEANQLYQRALSGYEARVKEVRDEGTTELGEEHRAVRELKGKIREISGHGSARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEK3</accession>
    <name>A0A1C1CEK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Effector 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEK3"/>
    <dbReference type="STRING" id="86049.A0A1C1CEK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02600"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02465"/>
    <dbReference type="eggNOG" id="ENOG502SPC5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5320938at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25312">
        <property type="entry name" value="Allergen_Asp_f_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650764" description="Effector 5" evidence="1">
        <location>
            <begin position="21"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="25896" checksum="BD318AF37EC95E8B" modified="2016-11-02" version="1">MRCTFNSLVLATLAIGQAYAASLTHAHSHLHSHAARRHDHVEKRATALTEADATKLTSLGVMSLGLNSFTANGQAWLGQDGPYQNEFVNESGEDLILLVWGVAGSWVNAVQPTITASIPAGESLWVSFADGASGAWTAVYPDTQLINGQASNTWGEFTFGQWGVVDVSREVNMSGHPMSIVGPSCVSDMDTCVFQCSEGNTCMFNYLLLNCENGSQPGANYGTFEGAPSGGCGGMGSSATLKTTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEY9</accession>
    <name>A0A1C1CEY9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02601"/>
    <dbReference type="OrthoDB" id="5406323at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23566" checksum="AE76D9129BA55084" modified="2016-11-02" version="1">MPHDGLYLICPTTARTNTVLSYDTTSDQIGLTDLDASLVPRSTFYIHKLANHDAYEIHNTHENKSLRASSSGMDIGRGDSDEHRSYRWKISHSSSGGYKITNVSHTSQRLTAKDILDLNQGGTVQIGTPYHGPWDLLRIDAPVSKQNQDGADVLEGKSAKEWRKVAQKIFKEGLKTIEFACADTWTERTADEQESYADLFRKYGEDAGLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFK7</accession>
    <name>A0A1C1CFK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General amino-acid permease GAP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GAP1</name>
        <name evidence="11" type="ORF">CLCR_02340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFK7"/>
    <dbReference type="STRING" id="86049.A0A1C1CFK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02340"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02145"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="77"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT47289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="585" mass="63272" checksum="1D2D69C19FF27C2E" modified="2016-11-02" version="1">MEKDLEARAGSPDGSSEVSEGKVEYPRASTTVGRFLDGFKRNPNARVTAQAIDANGRILKDQPPAEPALAMKLKQRHLQMIAIGGSIGTGLFVGSGSALASGGPASLVLAYGLIGLTLYCTTHALGELAVQYPVAGAFSVYASRFVDEAWGFAMGWNYALQWLVTLPLEIVAASLTLEFWPGSRGTNGAAWVTIFLVAIILINFFGVKGYGEAEFVFSIIKVLAVIGFIILGIIINTGGVGSQGYIGARYWYDPGAFNHGFKGLCSVFVTAAFSFSGTELVGLAAAETENPRLALPTAVKQVFWRIALFYMVSLTVVGVLVPYNDPMLLNGSSSADANASPFVIAVRNAGIDAVPSIMNVVILIAVLSVGNSSVYGASRTLAALADMGQAPRILGYVDREGRPLVAIIVSSLLGFLCYIVAAGPDTSGEAFNWMIAISGLAAIFTWGTICLCHIRFRRAWRMAGHTLDELAFKSQATVYGSWIGLIMNCLILVAQFWTGFAPVGYADMSASELVKGFFEVYLAAPIVLVMYLGYKLWYRTKIRRAGEIDITSGRREVENLQQILDEERRVRKTWPWWKKTWNTFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFP9</accession>
    <name>A0A1C1CFP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02607"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02109"/>
    <dbReference type="eggNOG" id="ENOG502SSR4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5423884at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="258" mass="28211" checksum="D0CB369330AE8B16" modified="2016-11-02" version="1">MAPAIAPRSISSSSQHMRYFSRSVSSAITSLSSSKDTTLISKTPVASLFALILREALQFTKQSLLSSPSRRKLVQPVFLDPHSPSLEISSHPLSKRQVQILAIPTTYAGLNSGPQPGALVGIVVGSITGFILILYIILSLFRLRGGGGQVVEEKVIRHSHRRRPSRSASRTSRSASRVISAASSPRRERIVREEETVIVEEHVDPPSIVDDDIVEVIEEHSPERRPPRKPSGRSGYRTVDPAEFGGGGAPMRKLGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG74</accession>
    <name>A0A1C1CG74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable Xaa-Pro aminopeptidase PEPP</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Probable Xaa-Pro aminopeptidase pepP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pepP</name>
        <name evidence="16" type="ORF">CLCR_03524</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG74"/>
    <dbReference type="STRING" id="86049.A0A1C1CG74"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03524"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01874"/>
    <dbReference type="eggNOG" id="KOG2737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="15">
        <location>
            <begin position="12"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT47509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="449" mass="50220" checksum="4A27D9CFA6874AB6" modified="2016-11-02" version="1">MSLTDVTLKAKYPAKSHCRRVAKFLTDAGFSRDGVIYLEAQKTRMVEDDDQAMHFRQRRYFFYLSGCKLADAYLTYNIPQDTLTLFIPPVDPDSVIWSGLPESRDEALKKYDVDAVLYTDEVNAALAAYGPSKSATVYAIPEQVSEHITFLAFQAVEFAPLKTAIDECRVVKDSYEVALIRKANEISTLAHVEAVKAARNATNEQELYGAFVGTCISNGAHEQAYHSICASGTSCSTLHYVRNDQPLQHRLNILLDAGAEYECYCADITRTFPISGTFTPESQTIYSIVDEMQASCFTMLRGGVRWEDVHENAHRVAIKGLKKAGILVGDEQEIFDKRVSVAFMPHGLGHYLGMDTHDTGGHANYEDPDQMFKYLRVRGAVPAGAVITVEPGIYFCDFILNPVLEDPELNKYIDKTVLDKYWTVGGVRIEDDVHILEDGYENLTNTPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGJ0</accession>
    <name>A0A1C1CGJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_03356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGJ0"/>
    <dbReference type="STRING" id="86049.A0A1C1CGJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03356"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01824"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="155"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="595" mass="64964" checksum="8959EA61E386D782" modified="2016-11-02" version="1">MASTDLNRTQTAPENRARRPARISLSRAKSTPEDVPHQLFSPQFMDDHGSHHYHVSATRDDRVDNDIDADADMDAPESPLSSDDTVSGSTAGESHEEELRFGVVNSRDLEAGFARPGLSSEKSTRSLKDPNLVTWEGPDDPDNPKNWTFRKKWAATLIVSSFTFISPVSSSMVAPALNKIGQDLGITQEVELSLTLSIFVLAYAIGPLFLGPLSEMYGRVIVLQLSNLFFLAWNIGCGFAQTRSQLIAFRFLSGLGGSAPLALGGGVLSDCFHAEERGKAISIYSLAPLLGPAVGPIAGGFIALKTTWRWCFWATSIVDAGIQVLGLIYLRETYAPKLLSDRAKNLRKETGNPNYHTEWESPDRTLGKVLRASLIRPFRLLGTQPIIQALALYMAYLYGLMYLVLSTFPSVWEDVYQESVGIGGLNYISLGVGFFLGTQICAPINDRIYRKLKLRNNNEGKPEFRVPLMIPGAVLVPIGLFIYGWSARRSVHWIVPNIGAAIFAAGTIIGFQCTQTHIVDAYSRYAASAVAAAVVLRSLAGFGFPLFAPYMYDALGLDWGNSMLAFIGIGLGIPAPLLLWKYGPILRAKSTYAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH68</accession>
    <name>A0A1C1CH68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4 11">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CYS4</name>
        <name evidence="14" type="ORF">CLCR_03399</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4 11"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH68"/>
    <dbReference type="STRING" id="86049.A0A1C1CH68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03399"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04489"/>
    <dbReference type="eggNOG" id="KOG1252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="728at2759"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007089">
        <property type="term" value="P:traversing start control point of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 10 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="376"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="462"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT47865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="562" mass="60661" checksum="634A7938CEAAB4A0" modified="2016-11-02" version="1">MSSSNGTRLNAEGTHLTSLELIGQTPLIRLNKIPQSLGIQATVYAKCEFFNAGGSVKDRIALRMIEEAEKSGRIKPGDTLIEPTSGNTGIGLALVAAVKGYRTIITLPEKMSAEKVAVLKALNATIIRTPTQAAFDSPESHIGVAKRLEKEIPNAHILDQYGNPDNPLAHELGTAEEIWKQTAGKITAVVAGAGTGGTITGLARGLHKHKESIKIIAADPQGSILALPSQLNEEFANQPYKVEGIGYDFIPDVLDQKVVDKWYKTDDRDSFHYARRLIAEEGLLVGGSSGSALAATIQAAKDLNLGKDDVIVTILPDSIRSYLSKFVDDDWLAANNLLPPTPPTEPQSPPSPSQLSRTPSVRKDDPFHGARVKHLRLKPVQTITSDSPCSAAIEVMREKGFDQLPVLAPSPSRRLVGLVTLGNLLSRISHGRATGKSPVSDVMFDFSHIGEVSVDKTDMSDLMTTSADPASEPAAQEKFSSEMTDKDTGAAKSRPRAQSKSKGKRKQFVEITVETPLSALNRFFEWQSAAIVTERDDKGALKPTAVVTKVDLLTWMLSEQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHD6</accession>
    <name>A0A1C1CHD6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">uS12 prolyl 3,4-dihydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TPA1</name>
        <name evidence="15" type="ORF">CLCR_03927</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54160"/>
            <dbReference type="Rhea" id="RHEA-COMP:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="ChEBI" id="CHEBI:138052"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHD6"/>
    <dbReference type="STRING" id="86049.A0A1C1CHD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03927"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08096"/>
    <dbReference type="eggNOG" id="KOG3844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019826">
        <property type="term" value="F:oxygen sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140311">
        <property type="term" value="F:protein sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000639">
        <property type="term" value="P:negative regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000014">
        <property type="entry name" value="Prolyl 3,4-dihydroxylase TPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="136"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="504"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="642"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="653"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT47929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="701" mass="78885" checksum="BFA21F0C2CE5C6FD" modified="2016-11-02" version="1">MKRKAPPSEQPPAKKRIVSDSHGNIQSAFRSDLFDEETRESFRKGYQQAKPYPHAVVRSLIEDSLLRSVRQEITTHIHFTLKETDIYRIHQSGDLANLSHLDAESLKHLPSLVRLRDALYSAEFREWVAAVTGAGKVSGMKTDMAVNVYTPGSYLLCHDDVIGSRRVSYILYLTDPEHPWQPEWGGGLRLYPTDTKKNRQGEDIQVPRADHSLNIPPSFGQLSFFAVRPGESYHDVEEVYHGPNLEADGGRIRMAISGWFHIPQEGEDGFEEGMEQTQAQKSSLAQLKSASSEFDEPQLVFRHFDEPRMVMDSQAARREIDPGDDLDTDDNILTEQDLTFLLHYMTPHYLTPDMIEEFSSSFADMSVLQLDHFFNPTFAANLKAYISKIENDEDDVLAPSAKASHPSTWKIARPPHKHRYAYLQTDEALHRDKCPISRILADLIHSHAFKKWLALVTGLKTKSLIRQSAIARRFRRGKDYALAHPYQGDAPKLEFTISLTPTEGWERQGIADEEADASKQKNEKKELNGDSEHSNGHNDKTQVKAMEVDSIRDSDPAEIEFGGEEIYMVGDDDEDEQLASTDSKALPSVGKKPSHDPAVYKAGDDEDDGILFTNAAAWNRFSIVLRDKGTLRFVKYVSQAAKGDRWDLKGEVEVDEAGWDGADDDTGEGEEGGETGEDEAEDEIDANDVDDDEDDEDDTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHJ8</accession>
    <name>A0A1C1CHJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_11291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11291"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08145"/>
    <dbReference type="eggNOG" id="ENOG502SWBS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5420214at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="302" mass="33881" checksum="88ABDD0565E36867" modified="2016-11-02" version="1">MSYESDSHLTRHSPAYYDGTNPSTSAQTPYYRSAPRPLQQPPIARVSPTLRSPSVPHGLDPVRLQTSISSGESGSTVGAEYKQYPTYKHFQYGPQVERGIIEDSTHRQSRAGSQHSGNRANESHHGGAPVVEDNSAIFQYIQEKSLAVEEEQEDDHALWILLWMSFLDPFHCLFSALYSVFAAILITILAPLRLCRQECSPSISLVRLVAPIFRNHLQLIYAKSLDNAHTFEFSPFCLVLVHAVSPIISIGNAVAAWIVAVFWVFAIVMGNPDGTEKRDDGRATVLLLRDWWEKYLLFAIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHZ8</accession>
    <name>A0A1C1CHZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHZ8"/>
    <dbReference type="STRING" id="86049.A0A1C1CHZ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04260"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08279"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF13">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="274" mass="29492" checksum="957CE507D1B7E5A4" modified="2016-11-02" version="1">MMPPAILIIPGSFSTAQMYYSLQAAITALSPTQETYMANLPSAIRNPPEQPATLLDDATFFGGLIEKLLPAANHNTAESDESSKDIILVAHSYGGVVATEALRGVSKQERLKAGKSGGGVIRVVYLAAHVPREGSSLEDTVGPPPEGMVAVGKDNFLRFLDVETIAKATFPDYPLDLALGQVRAMGRHSNASFTSKVTYEGWRDVAVSWILCERDLIIPPAVQRGYIDRIGQESGREVDLHVLDAGHCPNVTAPEALAEVLVRIVQAEVADQMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI72</accession>
    <name>A0A1C1CI72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI72"/>
    <dbReference type="STRING" id="86049.A0A1C1CI72"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04071"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08316"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="502" mass="53453" checksum="1B0ED4ED113D8499" modified="2016-11-02" version="1">MPIPVRSHSLIKSKSAATGPSSTPTSLGNVPHSEAADAKEPTRLTREPAHARATSKVSARAVTEQKPDDPGPATKVPVSKIRGDAHAGHGRTRNHLSATSSGVTRVAPATSGLAVVTATSRSQQWTGNTDTANVSTPVLSSHSRTLSATSKARRTAEPRNSQDEARKAGDLAASHALPSTAGKASVSASEKGKQVPFLRPNFSTYQQRYSPKKPNAVPVASASVPNKIAIGAGSADGVVSAAEIENLRDELLQLSVVQEKSSAALQAYEVSVKSRFRASFDDVAKQLSLLKSRQCDRQSTVNALAVSEWLGKQRQTPAVTHTGCDTLLLLAHCQKVLQDVSKENGPLKDAMQIFDEWCVYSSSRRSYRAADDPHDGDDAQDPGSFPRPSLVRPDPFLTEGWSASFSSVEARVQSCAASWTDLQLPPASTSLGLLIKMQSVLAEQILREIAMCRSVEGLIVREEQARIRTAVEAALQDAELHHSASAALAGIRRGVWNTYGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIS6</accession>
    <name>A0A1C1CIS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIS6"/>
    <dbReference type="STRING" id="86049.A0A1C1CIS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04441"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="113" mass="12688" checksum="590E72448698549F" modified="2016-11-02" version="1">MARLVLRGKLFESFAGYHYKAYWGVALGYGRYGMIRHKIESWIIIDCEALNRFLPESAPPKVAPESDDKAEAVDHYKEAMGNSVDDLDYLGIPAEETRDPRPSAAHLTTKNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIW0</accession>
    <name>A0A1C1CIW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pcn1</name>
        <name evidence="11" type="ORF">CLCR_04268</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PCNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIW0"/>
    <dbReference type="STRING" id="86049.A0A1C1CIW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04268"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08517"/>
    <dbReference type="eggNOG" id="KOG1636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035753">
        <property type="term" value="P:maintenance of DNA trinucleotide repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903459">
        <property type="term" value="P:mitotic DNA replication lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000008">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="10">
        <location>
            <begin position="118"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT48381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="250" mass="27747" checksum="6FAF3C6DEF19C9DB" modified="2016-11-02" version="1">MFRWQVVDAIKDLVQDCNFDCNDSGVALQAMDNSHVALVSMMLKAEMFSPFRCDRNIALGINLNSLTKVLRAAQNEDILTLKAEDAPDVVNLVFESSDADRISEYDIKLMDIDQEHLGIPETEYAATIEMPSNEFQRICRDLIAMSESVSIEASKDGVRFSCQGDIGSGSVTIRQSTNMDKPEQDVKIALSEPVSLTFSLKYLVNFCKASGLSSKVKLCLSQEVPLLVEYTLSGSSYLRFYLAPKIGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIW5</accession>
    <name>A0A1C1CIW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative NAD+ kinase Utr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_03956</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIW5"/>
    <dbReference type="STRING" id="86049.A0A1C1CIW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03956"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08587"/>
    <dbReference type="eggNOG" id="KOG2178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000005">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000025">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="619"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="655" mass="71310" checksum="0EDE9540541E70B3" modified="2016-11-02" version="1">MTTSSTISDCDAHNRSTSPSPSTPFFESTGISSLPAPSPVDNSDLLPPHGMATSSSKPSIGESILRQYAQHLDPIDGGSQTHATRDLDQPAPGSVSDKDPSGALTPVSESLRNSYIAHHPTVPVPKPLLLPKSYLAHRKNTKSIDIPRQTIMKALVSRRPSAGPNTAPLATNALKSAIADAEAEQQTGCSSPSSLTATFAGLQPGILSAAYSPTSTSFLRSPCFFHQRFDGVADIQRVLEEVADDDYSHSRLMQTATGVREVSKLLQRKPLKRAVRNVMIVTKARDNSLVYLTRDLAEWLLSTPRYGSELGVNVYVDAKLRHSKRFDAAGLLAKEPRFQKMLKYWTPDLCWSSPEKFDLVVTLGGDGTVLFTSWLFQRVVPPVLSFSLGSLGFLTNFEFGKYKEHLDRVMGDAGMRVNLRMRFTCTVWRADRSPGAAKGAVEEGEQFEVLNELVIDRGPSAYVSNLELYGDDELLTIVQADGCIFSTPTGSTAYSLSAGGSLIHPSIPAILLTPICPHTLSFRPMVLSDTLALRIAVPHKSRSSAYCSFDGKGRIELKQGDFVTLEASQYPFPTVMTGTNEWVESVQRALRWNVRGAVQKGWDDGDDDDSDHVEDKWDIDIDASPLGGTDSGIGPSEDGDHAASPMRRQLSMLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ06</accession>
    <name>A0A1C1CJ06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum chaperone BiP</fullName>
            <ecNumber evidence="4">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Immunoglobulin heavy chain-binding protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">bipA</name>
        <name evidence="17" type="ORF">CLCR_03923</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ06"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ06"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03923"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08623"/>
    <dbReference type="eggNOG" id="KOG0100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000009">
        <property type="entry name" value="DnaK-type molecular chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650841" description="Endoplasmic reticulum chaperone BiP" evidence="16">
        <location>
            <begin position="43"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="661"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT48500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="687" mass="75246" checksum="018B0223C749713F" modified="2016-11-02" version="1">MASGNVQRRPRRTTTSALQWTTLFYLLLIFVCPLALIGKVNAEDQTPLNDSDTNYGTVIGIDLGTTYSCVGVMQNGKVEIIVNDQGNRITPSYVAFTDEERLVGDAAKNQYASNPTRTIFDIKRLIGRKFDDKDVQRDAKHFPFKVVNKDGKPVVNVEVNGQPKTFSPEEVSAMVLGKMKEVAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLTVLRVVNEPTAAALAYGLDKKGKESQIIVYDLGGGTFDVSLLSIEDGVFEVMATAGDTHLGGEDFDQRVIDYFVKKYNKENDVDIRKDLKTMGKLKREVERAKRTLSSQMSTRIEIEAFHNGKDFSETLTRAKFEELNMDLFKKTLKPVEQVLKDAKVKKSDIDDIVLIGGSTRIPKVQSMIEEYFGGKKASKGINPDEAVAYGAAVQAGILTGEANTEDLILMDVNPLTLGIETTGGVMTKLIPRNTLVPTKKAQIFSTAADNQPVVLIQVFEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVSFELDANGILKVTAGDKGTGKAESITITNDKGRLTQEEIDRMVAEAEEFAEADKAFKEKIDARNKLENYASSLKNQVNDEEGLGGKIDDEDKETLLDAVKEAQDWLSENADSADTEDFDEQFEKLSQVAYPISSKLYSGGGGAGGMPDYGDDDDDSYGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ38</accession>
    <name>A0A1C1CJ38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ38"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ38"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04014"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08648"/>
    <dbReference type="eggNOG" id="ENOG502SIP1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4161473at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="573" mass="64106" checksum="5A8A48A436272268" modified="2016-11-02" version="1">MNEYPGLDRVFLWEWAAQFSSQRQRRPPLPSANTVTTSRAGETRSSIANGAQPASGQPPSAEPEQSSFLNEKDGAPYQAHGRNHIHYSVEWRVELDTKILATQSESNVAVSPSCYWRHVLKGRFEQAVRRAFVGDQQPRHEHTTVVVSVTDPAQGDLTKSYAGLEIDWAAADNHLLDWSSYFRRGNALRVTLTFQFVAPNPPAVQRSVTPRGDGGRHVSASGRMPVQRRQESFTAQELRGQPPFLYDLCVFMRCPTSCLLGPYCWVNSKGVHHRMTPECFKLLEAHVTHYGMPASHSDMPLDVQRQLVMDRQAQLLNAVPGMPVQVGNVSPGRRPQAQLMGVYVGQDYSTLRRQSDGAVLTQRDLTRLHDDPSMLRRQSDGDVPQQKGLTGLHDDVSAVRRQPDSTGTQRTEITAVDNAVVQPQQTRSTTADDVAVQLQQTKLSGDDNTAVRPQPKQSMAVHDAAVEPQPTELTGSHDDELRDYATWQQSRVQSPWLKDEFGKAFHVAVRNGFSLDLLYENADPHALIDEGVFEGVACYFCRRRDIDRFRDRKRRLSADADTDTDTGMGEDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ67</accession>
    <name>A0A1C1CJ67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_03841</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ67"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ67"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03841"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10288"/>
    <dbReference type="eggNOG" id="KOG2238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26740at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF19">
        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="275"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="483"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="552"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="742"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="568"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="663"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="775"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="868"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="902"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="955"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT48560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="965" mass="106172" checksum="185C92E1944BFC32" modified="2016-11-02" version="1">MASLQWFLFVYVLGGLTFLPLVVILVLAHAYYTLPSPHNGSAKAPLDDDPAQLVRADDDKAAFKTATDSLAEQFHRRHDTDVAAGYFAVCREYVPGVVLTKPPDKITPAGDVVAQESPSVYQSMYRSIFDRSQKPTIEPNKDNTGKGTRKTNNVFYVVLRHGHLMLYDDIQQLEVRYVISLDYHDVDIYAGGEDIPEGELWIKRNAIRLRRKQTQFGDTATSMPFFLFGQSLSEKEDFYHAILKNQEKGISDEPPVPQLFDVGHAVLLVQKLHSSEEHLQTRWLNAIIGRVFLALYKTPEIEGFLREKLSKKISRVKKPTFITKLGLRKIDLGTSAPFFTNPRLKDLTVNGDCTIEADVNYTGGLRIEIAATARIDLGARFKAREVDMVLAVTCKKLLGHALVRCKPPPSNRLWFTFEKMPQLDLDIEPIVSSRQITYTFILRTIESRIREVVAESIVHPFWDDIPFFDTMAQKYRGGIWKREAQDTTTEIPNEEPEDLSEADSSGNPTSAVLSKDERVLSMPALSDNGSIGTAKAAKKSLASLNEIWGKKKSEPVDRPDSATPRLLRSTSFANAADPTITTNHADANTPTRGSEAGAHRESVATILKDISARSSSSNQSGPDSPAGSPPVESAMAMAMKGRSSSTTSGASDDREQAGRLSRRSSSLPQTPTNASRTSLAPSETHETKDESRPPTVEAEKEPPKKFSFGAKSLTSGDRKQALASVNAAAAAAQKWGWGVLARKRQREAQAAAAKAAEEASNGASSPREPMGRGRPLPPPGMPLPPPERPKSSSFLGPKRKPVPPPMLPKRPETDGPTPAKSSPKPPLPERRKRQSSMQPADEAENEVLVVEAPIESAPASPTDDERYDGEHRDDFFGHGEEQLDPAPPVRPTPDASLEQDEPAEKLVNRATPPRDEVAEEHMHTQPLSAEKPSNSTSNSTSEYSPPLVQEGESGEIDRQEIRMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJJ2</accession>
    <name>A0A1C1CJJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase omega-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gto2</name>
        <name evidence="3" type="ORF">CLCR_04822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJJ2"/>
    <dbReference type="STRING" id="86049.A0A1C1CJJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04822"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03253"/>
    <dbReference type="eggNOG" id="KOG2903">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF25">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="168"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="473" mass="53273" checksum="CB2318204F0942A6" modified="2016-11-02" version="1">MGDSRPTHQHADADGHFRRKDSQFRNWISKEPGSKFTPEKDRYALYANYGCPWAHRTIIVRSLKSLEPIIQLITTDFDLTENGWTFTGRNGSMGADPLYGFTGLKQLYLKADPTYTGRYTVPVLWDKKTETIVNNESSEIIRMLYDQFDDFLEPDQREVNKPGGGFYPPHLRKEIDAMNEWVYNTVNNGVYKIGFAASQEAYDENIYPLFKSLDRLEEHLKAPAHQPYLFGEYITEADIRLYTTLARFDVAYYNIFNCNLKMIRHDYPRLSKWLRHLYWDTSDHTNGGVFKKTTFFEVYKYGYLRAKGRQMHGGTDLGWPVILPRGPIPDIEPLTDEEEKDLINGSGSKLNGLTIADLPTGLNTSSGNPFSAHGDKGGMGALFGADVDSPVNPDDGVATPTTVATTTGVGSPASTRNGGDEVDDADAFDENGEFVPRRMIKRRTTYSDANAKWYKAAKKAEKKAGAPPIHLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJQ1</accession>
    <name>A0A1C1CJQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative calmodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_05002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJQ1"/>
    <dbReference type="STRING" id="86049.A0A1C1CJQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05002"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03149"/>
    <dbReference type="eggNOG" id="KOG0031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="143"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="211"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT48753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="321" mass="34275" checksum="ADAA8E5356D2B2C5" modified="2016-11-02" version="1">MSSYKSTFNSPRSSPFRRPASPGSPTLVSNGRPNTPPTNRSGASPLTSPSKLKHAYTVSEEEEDEEEIIVSTPSKATGDAPFRRAQTEPPPSPPTRQSQLVSPSKFDRPSLSVLDSGTATEPRRLVSNGMLSQNDNLSKLPPQLLHNMRESFSVLDSNSNGTIDASSVAETLQSLGLHESNLSQFFAPGQPQQMSLPQYLGQLANILVGLSPQQELLNAFSAFDDDDSGQIDIAELRTALLNTAPDPGERPLSAKDIDRAMEGFTGRRILGKNVIGIAGVRGLKDPAPKKGGDVFRYQEFVGNLTGGPATEGGHAQAVASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJS4</accession>
    <name>A0A1C1CJS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pgp1</name>
        <name evidence="9" type="ORF">CLCR_04888</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJS4"/>
    <dbReference type="STRING" id="86049.A0A1C1CJS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04888"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03130"/>
    <dbReference type="eggNOG" id="KOG2707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="8">
        <location>
            <begin position="68"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT48775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="452" mass="48929" checksum="51C15BF892E0D980" modified="2016-11-02" version="1">MLHACRSIKTLPSRCWHAFSTSARRRNLLTLAIETSCDDTCVSILSTTNRHNGVWADLLFNEKVTAKNTGKGGILPTESLESHQSNLSTLLESALPYLPNAPDTVGPRTVWLGDGSPVQKPDFISVTRGPGMSASLGVGLATAKGLATAWQIPMVGVHHMQAHALTPRLVSAMGKDGHDHHGHSPNFPFLTLLVSGGHTMLLHSKGLLDHEILATTTDTAIGDELDKCGRLILPKELQAGTPDTAFGKYLSAYAFRTPEDFASWRVPATRAEEIDKPVNEFGWGLSTPKAQNRELAFSFSGIASQVKRLILARGIAGGMTEMERLLLARSALGAAFEHLGSRTIIALEKLRAEGIQIDHLVVSGGVAANTFLRYYLRELLDRRAFGRTQLVFPPVEFCTDNAAMIAWAGTEMFEAGYSTELGCAPVRKWSMDSHQPGGGILGIEGWIRTGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJX5</accession>
    <name>A0A1C1CJX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05224"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03130"/>
    <dbReference type="OrthoDB" id="2559882at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="135" mass="14574" checksum="FD5C5F15200C8AB1" modified="2016-11-02" version="1">MQNTRSLVRSAQSQLHAARPLTRTFVSSRPRWATSTGPAMDQYNKGSDAQKPQSEHPKNDDSLPNFVEGKVGQHEESRGEGSRAGFGSGGKSHATGESIVPEAVQKVAPEKLEKALPEAVHPTKGSEIDPHPQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJY8</accession>
    <name>A0A1C1CJY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05294"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="89" mass="9805" checksum="77AA4B45D5B271BF" modified="2016-11-02" version="1">MSDGVQLALAPLVSSAKECRKLRWRLASDSTRLGMRVYQGLAYVNARSSQSEDVMLSELAKSVEERAKSHHRHALNCGLSLNTVMAFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKC4</accession>
    <name>A0A1C1CKC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Estradiol 17-beta-dehydrogenase 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">HSD17B11</name>
        <name evidence="3" type="ORF">CLCR_05049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKC4"/>
    <dbReference type="STRING" id="86049.A0A1C1CKC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05049"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02954"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF122">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="294" mass="31047" checksum="7DAE484ADB043A2B" modified="2016-11-02" version="1">MGDANAPPFPAPVKGWHADTYPGIDPSRPELSLKGKSVIVSGGGGTIGFATVKALATAGVRLVGIVGRTQKTLDETSSKLKGQYPGTKIVSATGDISSFSSLESAFKQIRQQAGNPVDILVHNAGHLASPGPIATTDPKEWWTSFEVNILGAFNSIRAFLPVAPTNATIVNMSTAVAHVPTTMISGLSAYSSSKLAALRIFDFLQDEHPEMHIVNMHPGIIMSDLNSKHGAATPMDTPELAASFVVWLCSPEAKFLKGKLAWANWDVDDLKAKAAEIQNSPSLTMALTGWSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKM8</accession>
    <name>A0A1C1CKM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04520"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02874"/>
    <dbReference type="eggNOG" id="ENOG502SBBS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3439035at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1194" mass="130284" checksum="B6940225A6BA5179" modified="2016-11-02" version="1">MARNKENNPLSSSKRNGQHTRNPPSADFFTDSLLDDSRLSSASLIPSPSKAKPAAVKPRRALPATRALQTAKDLGNKQSRTSLLDYTNARTSKQLKTSPKLTKRKSPSPTRTNGLTTPPQSRHGPPVRSPSEFSSPPGGLHESYQRIADEEDLAATERDVDSDEDEVERDQPDTLELDMNAIVPEDVQSKGHTYEDCASQHTTPVQSPVDDRTGSLSAPPTLGTLDFVQNEMTDRVLAEKLTPHVIDRARDRARLQRLRQSVPINFGDRANGKVNGGHRRDDLASIANRGPISFDNILGAGANGLHKAYSDTSADATPNNNLRPLGTGSRRLKPTTVPEDDESGSDTPDELREVERTIDLNKARQNRESVVRTEGPGPGPDPRASVFSRSYGGSGPYQDPSRIRSYQPPLSDPTMASVSSTHSEPTSAGAYDKQTRDSTRAFLARWRHDAVQRRAAKAQEDADKRESHPEPAAAEEHPATLQKNEDDAGSEIDWAAAGADIPLPSVEQSSTPRDSPPLKTLPSSISKQSSTDRIRKWENDFTGMSFQVSESPPVRGRNNLDDSLREKEMEDLTENAVASDRLDEIFAKDSSLNVRKSSRNLTHKDGKPTSTEPQGQSSVSQFHGSHDVGQAIPDTPIVVYRSSSQSTDKSKSSERSVSNSLDQLQRLARAVSTTPRASPALNDMVREIEEASAIPLPGPEEDPKARSPETRSNGVTLGRRVAETPKIVGAWTDTILPDTVKTQKQTQKVPQYAQTPHISAGGWIDTPLPNGARLTSVPIPEVIEEVTEFVESGGIQKESQKPARAKDETDQTAATGEEQPRAVPHPPTTQQIILPPSALTNVLNEAKQKRLVSRDTNEARPESRDDTDTLNLGDATIQSMEDLLTDAADITADLTTLIRTSAEDEVLALRQRNDAVAPTVRGDEVGSTSDVAFIGHLTSRMERLMSNLHEARKGISRLEQKVSHAPSVTVTSMDQQTQALVAVHDPSQPCAVCGRSNDDLTPHDHPLAPIITSFLGFPITYTTFTLPVPLLFHPRTIATPQGSNSKMLTLLPGRPTWLGYLILTFWTWYILECIMTELYARPLYAERYPFPPPGVTEPEFPFVLPTMLCRGIFGQYGFAVLEMLGNMLGGAYKVLVAVYRVFAMAVGWSDGFVDDERAKHVVAAATRSAIKVAQSIVSGADGSEGLSMMNDELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL96</accession>
    <name>A0A1C1CL96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL96"/>
    <dbReference type="STRING" id="86049.A0A1C1CL96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04568"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02646"/>
    <dbReference type="eggNOG" id="ENOG502QTAC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4188028at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="390"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="692"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="720"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="768"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="851"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="868"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="902" mass="98121" checksum="1C56FFB82BA71D99" modified="2016-11-02" version="1">MPRKRSPREPTVEFHMRTRNRSIKTTPEPSNSSPEDSSLSELGSPPDPPPTVLGSGTRKRKLSSSSSNDPETPSESKRPKRKITAAAALPDSVKSRKRRGRPPAFGLNDTSSTSTIHISPPATLPSITPPESAKPSRRNSAVTQPDNVEALPETVVQAQIQPAPTVGESSTALRRSSRHIKPSILQGPVAVDTPSKRPSSSTAEAAPANVRNHKPSGTASDASDTIPKRKRTLRSAKEATAQKPFNLWDKEKELWPEFDRNNVIYYANDGTTQYHPAEGDETPESRSPKKPARGGARTGRGGGHSNGGGRKGKSRGRAGRGGSPDPPERRQPLSQEEKAMISLLKARQQELKRFFHVVGAQQFDILEQMANRDLNRMAKKATAHKRVPEYATIVEELEAAKQDAEDLARKRYDVQVEAEMRRLEAEKEVIEQQWMNRRAAARKEHLAAAEGDIILFERAYRAAHDDTHTESGSDMMEYFPHYHELPEPDTHPRGYSSSRIKDEKPFKRQLGESYDEQARQQVLNEDVIGPLLKQIEQRNKEWRAEQQSNKSRTMDALTEEAARELAKIGGYLVPRPMDMAEANSYALSALADVSEWVAQQHAQKQYIYVPLAKGEAFPAQGLDFSPLPGQAGPPPRPQQAYQQVIRTNSRPRGRRLKYPPLTYEQAVSATTSSPGLPPLQPQHHTPPQGGYFPPPTTPAPLPGPLGFEVSRIISSGPGQPIAPAPPKAAPAPPRPNVDIFRHNTRYPPPPPPPSHSSHARQNSLTTASSSGPGPSPQQSQPQYQPQPQPQQYIFQTPQQPFQHQAAPPPSSGQQYGPPAGAAPGPVTTAPGPSTSPAGPNAASPSGSIAGQQTKMPMTFVNQTIESRSAAGVSNSNGNGNGNGVNAAGNDKGSGRRVLLPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLC9</accession>
    <name>A0A1C1CLC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cgrA</name>
        <name evidence="10" type="ORF">CLCR_05225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLC9"/>
    <dbReference type="STRING" id="86049.A0A1C1CLC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05225"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02616"/>
    <dbReference type="eggNOG" id="ENOG502S7VB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3942380at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT49325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="135" mass="15697" checksum="60AD0D21102D1767" modified="2016-11-02" version="1">MSVTKSSPAEAVPGAVIASAVSKASSQLTQLTQKLGKRVNGKNWHEPKKPFRPTAGQTSYAKRKEQEKVAQIAKAREQEMKDEKEAERSRRIQAIKDRRKAKEEKERYEKMAEKMHKKLVERRRRREKRNKLLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLV8</accession>
    <name>A0A1C1CLV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitronate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLV8"/>
    <dbReference type="STRING" id="86049.A0A1C1CLV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07383"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09751"/>
    <dbReference type="eggNOG" id="ENOG502RHJM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="343" mass="35949" checksum="23CE5930AD21FA9D" modified="2016-11-02" version="1">MAEILRSYLHWASSPLIVNAPMGGYAGGKLAARVTQAGGLGMIGSILHGDLERELAVAQEALGPIQGGHPFPIGVGVLPFVADIDLVLPILQQYQPAVLWLFAARELEDYAVWASRVREVSPQSKIWIQTGTVSAALKIAQLAKPDALILQGADAGGHGFERGASIVSLLPEASDVLTMNGLGNIPLLASGGIADARGAAAAFTLGASGVILGTRFLAARETNVPPGYRDLVLAASDGAASTVRSKLFDNVNGPNIWPDAYDGRSLVTESYNDFIRGVDIDHIRETHRKSVTGTDAGFGTTNRANVWAGSSVGLVNQLENAADIVEEVRSGVTQILKNATARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMI9</accession>
    <name>A0A1C1CMI9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_07152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMI9"/>
    <dbReference type="STRING" id="86049.A0A1C1CMI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07152"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09959"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650965" evidence="8">
        <location>
            <begin position="18"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT49717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="437" mass="48435" checksum="20C6258A6342F491" modified="2016-11-02" version="1">MIAMFGFSVFCFGCATAKDLQTVMICRFFTGFFGSCPLAVVAAVFADMFDNTQRGTAIVIFSSMVFMGPMLGPFIGGFINKSSLGWRWNLYLPGIMGSVAVILHTAFIHESYAPVVLVNKAAELRRRTKNWGIHAKQEEVEVDFKELVTKNFSRPIRLLISEPIILAITCYMSFIYGLLYCFLTAYPLVFQGVHHITPGVAGLPFFGMVCGIFIVAGYIIWDSKNYNRKLAANGGIPVPEWRLPPVMIGGVLFAAGLFWFGWSGYRESIHWIVPTLSGLFTGFGLLAIFICCFNYLIDSYLMFAASAIAANTFLRSCLAAGFPLFSRQMFNNLGIEWAGTLLGCIAALCVPIPICFYFFGKRLRQKSKFAPTMQIKKPVDEENTSDDSDQEANMAALHATRSRAHHDLEVRSRRSRTNGSLATTPSNPAAEDPEKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMS5</accession>
    <name>A0A1C1CMS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMS5"/>
    <dbReference type="STRING" id="86049.A0A1C1CMS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07079"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08736"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF33">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="350" mass="38399" checksum="83B3E088F906D379" modified="2016-11-02" version="1">MADNVKTAIVTGGCSGIGLGLVRHLLSSPNDQQWRVVIADIRPEAYAAISSTLDGSRHMFIHTDVGSWDSQAALFRRAYDYGGGKIDFFAANAGTAEREHLTLGNPLRPEDVDGEPTQPNMLCTQVNQIAVFYGLKLFVHYTRRTAKRLKSESSAAAAAGGTFTPKMVITSSCSALYPFPVAPEYCATKHAVLALTRSLGPLLHTTDGIGLNCIMPAYVATNLTPQEVTDLWPKEWITPIETMLRAYDELTSPTGAVRDDGKSDGANGTVKTGQSVECVVDKLFYRQPVAYADESQRFLIEQAIDMNGEWRFRCIINPPSILLVSHFWLLNRGFSRDPRPWGAMVLGEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN26</accession>
    <name>A0A1C1CN26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07624"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08844"/>
    <dbReference type="OrthoDB" id="4119258at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="199" mass="20215" checksum="8C982F442B37225D" modified="2016-11-02" version="1">MSSTGTRSDLPATGSTYQPTKSEAISFSNNTPFGSSEGGHHHHQHHQHQVNGPDPNAATATATATTATTAYDSVTQQPTTAMGGTGTGQSSAIDIPDRANPTTNAINYADEANPLQAHHRPSLAAAAAAAAGDNEHHGAPVGLGGDETIRRHSVAQNAPGKLGERGENILGAIGFGGAAVERPKEDQGIGEKIAEFLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN62</accession>
    <name>A0A1C1CN62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN62"/>
    <dbReference type="STRING" id="86049.A0A1C1CN62"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07357"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08841"/>
    <dbReference type="eggNOG" id="ENOG502RYFN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9971601at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142">
        <property type="entry name" value="METALLO-HYDROLASE/OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142:SF2">
        <property type="entry name" value="METALLO-HYDROLASE_OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="355" mass="38778" checksum="27BEB4B42B867B1E" modified="2016-11-02" version="1">MAAPVGADADADATPLLDQLKGSFERANDGKVPVLTHLNDDTSWLLSLAYPDQVSPPKGRSRYNILIDPWLDGPQEDVASWFSKQWHLMESSVRTIDALNAVLCDAERSESQSTTEAGRKGCSFIDAIAISHEFTDHCHQATLLEVDRAVPVIATTKAAQLIRTWHHFDTVMEMPNFTTGTQWRTTSIPPLPSWLGISRLVTNSDALYYHSAVMICAQRPNCAAEAVDALIYTPHGVEASTLSVVATASPPVDVLALLHGLHDVSIKWSKQLNLGAINAVKAQQMLHAKYWIGTHDEQKRGSGLIALLLQRKIITVQEAIDRVQAAEKEESGHASASIEDMTCVELKNGESMVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNW2</accession>
    <name>A0A1C1CNW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cecr1a</name>
        <name evidence="12" type="ORF">CLCR_06897</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNW2"/>
    <dbReference type="STRING" id="86049.A0A1C1CNW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06897"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05793"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="11">
        <location>
            <begin position="242"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="580"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="581"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT50189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="612" mass="70259" checksum="B026B15E01E741A4" modified="2016-11-02" version="1">MPPQAEMSDDESVDSQVEWELDEGIPQVDDPFIQKYMAGRQALIEQEKKQRHDRAFKQGMSPMAKQAAKIMASIRRRELQSVWTSEFEDSLADKNGGNLYPGMMFTLARDRMETTDLWNIMEKMPKGALLHAHMDAMIDIDWLVDQALAEKGFCMLAPEGLSDKVKRTTGALQFRYYPDEEIKKQKNPGSIWHAAYQSNTPIPIREAQRTFPDDETTFKKWLISRCTVTAEESLCHHHGLDAIWRKFQSTFLVITWMFTYEPIFRRAIQRLLGQLAADGITYVDFRIAFKFEFRRQGQTTGQIGKYDDFFKVLGEEIDKFKRSEAGKGFIGARMIWTVVRREDNRILAGSMKECIRMKKKFPQLICGFDFVAQEDRGRTLQDLTPLVFWFKKKCAEAGVDLPFFFHAGECLGDGDSTDNNLFDAVLLGTRRIGHGYSLYKHPLLIDMVKEKKILVESCPISNEILRLSSSILSHSLPALLSRGVAVSLNNDDPAILGHGKNGLSHDFWQAYMGFENLGLEGLGTMAENSLKWCAIEDQKPGEWAKEIADGYLGKGTKAKLLRQWRAEFEKWCQWILMEYPLEAEEEDGEDEDEEESEDDEDDEDDEDEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP16</accession>
    <name>A0A1C1CP16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_07113</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP16"/>
    <dbReference type="STRING" id="86049.A0A1C1CP16"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07113"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05745"/>
    <dbReference type="eggNOG" id="KOG1596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT50245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="324" mass="33597" checksum="F46351E2EEC759EA" modified="2016-11-02" version="1">MAFGGAPRGGRGGGRGGPPRGGARGGRGGGRGGGDFGRGGGRGGGRGGGRGAPRGAGRGGRGGGGRGGGKPGIKGGAKVIIEPHRHPGVFVARGGKEDLLVTKNLTPGESVYGEKRISVDSPTNPGTDGEVNPAGTKTEYRVWNPFRSKLAAGILGGLDDIYIRPGASVLYLGAASGTSVSHVADIVGPTGRVYAVEFSHRSGRDLITMATHRTNVIPIIEDARHPLRYRMLVGMVDVIFADVAQPDQARIVGLNAHLFLKVGGGVVVSIKANCIDSTAKPEVVFANEVKKMREERIKPKEQLTLEPFERDHCIVAGIYQHVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP81</accession>
    <name>A0A1C1CP81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP81"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06751"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05693"/>
    <dbReference type="eggNOG" id="ENOG502SABV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64281at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
        <property type="entry name" value="DUF7492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650942" description="DUF7492 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7492" evidence="3">
        <location>
            <begin position="22"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="720" mass="75278" checksum="43B992CDF9AC455B" modified="2016-11-02" version="1">MPIKSILSSALIGLIASAPLALAHTWVEQLMVIAPNGTLVGEPGFPRGNVLRGTPGFGDPTMVNLIPPDGRTINQILPSDLMCKSSQTSQTQTDGSPRLQASPGDAVALRFQENGHVTLPDNQPGKPKNRGTVYVYGTSRPSADDSFLAIHRVWTPDGTGGDGRGRLLSTRNFDDGQCYQTNGGAISQQRQQQFSHPFGMVMGNDLWCQQDIQLPADMPTGQPYTLYWVWDWPTMPGTPGFPNGKQEIYTTCMDIDIVGDSGIVPVSKAQVNFAQGQPYDLAAVPDQMSDIANPTAVTGETIPFSNVVTTFLARTVSSPTTTTPSLTVSSPTGSTIAFSASATGPAAGGASEASIFAATASDTAIPGFLSVHTGSTAGPGLETQTFTVIPIGVTADSSQPTGDANGNGRGGRGGDSNSMWSLLPAFIKSRLKWFKKASANSLNSSGPQVTGAPNAVANAQQVATFTEYESVTETLLQTVYVTKYTKRDASESYPAAPTVASDGFSSPATSPFSRTRPWANLNFTRSGGPPPWLSGDSALRTRRPHGRPTGWPQGNHSSSGQDHGDKDYTTTSTDQTTITVQSIVSLTTYMPSAPSSAAAAVTAADTKAIAVSPFPALPTIESVSSTSTFTYTATITVIPTTSTSTLSFPTPAPVPSSSSSSSEQQQPQSLTVIPVPDPAATPAPEAASTNHAAFRLRARNPFVVLGWMSAEDAKTTSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPF3</accession>
    <name>A0A1C1CPF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Vacuolar protein sorting-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">vps17</name>
        <name evidence="10" type="ORF">CLCR_06830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the retromer complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the VPS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPF3"/>
    <dbReference type="STRING" id="86049.A0A1C1CPF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06830"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05640"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000046">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000034">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014461">
        <property type="entry name" value="Retromer_complex_Vps17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011791">
        <property type="entry name" value="Vps17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="176"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="9">
        <location>
            <begin position="306"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="506"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT50351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="616" mass="67196" checksum="4F0980B903E6095D" modified="2016-11-02" version="1">MDYTAVAGEADALHGSSPWGSSSPRAPRGFPQATAPDSPESPQPVRGHSYNQSQDSIPDSPYLPPPDQPGTPGFGDNTVPGEAAQGQQRAGVPQHSQAPAHHPHDAQAGQQGHQYTGQAQQRPGAARYHSTRQNRPVPQYKLQAKVTALERSGRKDPVFRFDVYTNLPKFRTTQFRDVRRTHGEFVKLADHLVSSNPEALVPAVPPAQTSAGVGTDEDEARVKAAIQRWLNVVCSNDVLMRDEEMVFFVESDFGYSPVVRMKQPATGVRRKVLKQFAPPPDDTPELHEARPVVKMFYLGALDTSQKLERVVKARRALGLGESSLGEKIGQMAVQETHAGLATAYRKLGRIVQTCGDYHAAQGTAEATTLGDALTYHSSDAFIVKETLTNRHILLRELLQAEASRRSKESAVQRLKSSSSVRRDKVDEAISALDEAISQESYLRSKTHRVTANLLLEKRRWFSRTSTEFMLSLREYVLRQIEAERRTLATLESVRPDVRAIDASGGLSRLGRENHPTVRRISMASSQGAKGDSWSGVPRSRDALSRSMSGGFGPGALGVPILPEDEENGANGAGGAQQGGARPRSGTGASLERVKEDEDEDRVDARNAASRLAQSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPH6</accession>
    <name>A0A1C1CPH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPH6"/>
    <dbReference type="STRING" id="86049.A0A1C1CPH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07054"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05615"/>
    <dbReference type="eggNOG" id="ENOG502RSGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3945378at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650952" evidence="3">
        <location>
            <begin position="26"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="470" mass="52997" checksum="E4EF761709B590E8" modified="2016-11-02" version="1">MAASTGLLSYFAMLLFLSSTHFARAAGTEQKTKWLVPRTNITGPNPNDYECESARAADYYGIGVRLVIRDPQGIYFSWITGWVANSFVAGDIGGALDTNAIFLFANLVAMVRCTITKVLTQLDCVILMHLSGGTVFSVLSLWGYRTCHYLGEGHKGIRHFGGFGTHLRLLLSMAVAVYGLWFWIIGIEPDTTGVNVDAGPCKTVYTFMFAKVRADGGIRIFYIAICVGCVTYFGIMLLASTLALYARLAKAANLAKQGKWRTSTRLHYATGLDHKEIFYFLRIGNLIWILWSMILVECTLNFNHVKAVLGPGNRIFFPSQLIPMIIGCFSFVRLMYKVLEQWRDPDDEPSLPNDPRLTGTRQEFPGTKRFFKVFAPPTNALNRRPQLPEDMPPEDTDMDELLQGEPIRLRYLVTWLPWLSLLPWWTKNEHKPHKRDTENVESDRSHSPSSTLHGTPTPPNFVNPYKSQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ31</accession>
    <name>A0A1C1CQ31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alkanesulfonate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssuD</name>
        <name evidence="6" type="ORF">CLCR_07196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ31"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ31"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07196"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05441"/>
    <dbReference type="eggNOG" id="ENOG502S7YG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2558704at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008726">
        <property type="term" value="F:alkanesulfonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046306">
        <property type="term" value="P:alkanesulfonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01094">
        <property type="entry name" value="Alkanesulfonate_monoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024014">
        <property type="entry name" value="DMSO2_SphG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050172">
        <property type="entry name" value="SsuD_RutA_monooxygenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04021">
        <property type="entry name" value="LLM_DMSO2_sfnG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847:SF4">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="5">
        <location>
            <begin position="41"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="401" mass="45619" checksum="E62F7B95974928EE" modified="2016-11-02" version="1">MATNGTIGIDDRKTDVNAAPDRIKFAYWVPNVSGGLVISKIPQHTNWDLESNVRYARTAEDVGFEYALSQIRFMAGYGAEFQHEPVSFSQAILHQTKRIKLIVALLPGPWNPTVAAKQIASIDNYTNGRVAVNVVSGWFKLEFTSIGQWWLDHSERYRRSKEFIQCLRGIWTQDKFNFTGDFYQFHDYTLQPKPLKWEGRPHPEIFQGGNSVDARENAATVSDYYFMNGNTLEGFIEQIEDVKDRARREGRGDQVKFAVNGFVIARDTEEEAVRVLQEIQGKADKEAVEAFGEQVKNAGASTANKTGMWANSKFEDLVQYNDGFKTKLIGTPEQIADRILLLKSLGVSILLTAFLHYDEEIERFGKDVIPLVRQLEEEGRGKDREYEIKLTGDVYKARPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQT2</accession>
    <name>A0A1C1CQT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09076"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09489"/>
    <dbReference type="OrthoDB" id="10459397at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1600.10">
        <property type="entry name" value="Outer membrane efflux proteins (OEP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56954">
        <property type="entry name" value="Outer membrane efflux proteins (OEP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25397" checksum="2FE0F15D80361BDA" modified="2016-11-02" version="1">MASPAQTTSSSPSNLRLIDTSQLCESCAAHISPVGHGHNTSSPHAPQSNINNSSSSNNNNNSDNNERNEPSTSTFTPTETPEASSSVSTPAPAPAPAPTATTEDIVQLIMISELRSAEEKLEQGHADLETARRAFEHERRGVLASMRNARESLRVATDGYWQNTHDLSVAMTVFRREKHEFENAKAELEREKAALEEAREAFEAEVQAAHTRGERRKKIWRRVTGWLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQW0</accession>
    <name>A0A1C1CQW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">POT1</name>
        <name evidence="13" type="ORF">CLCR_08655</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQW0"/>
    <dbReference type="STRING" id="86049.A0A1C1CQW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08655"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09541"/>
    <dbReference type="eggNOG" id="KOG1389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF5">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="18"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="291"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT50897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="408" mass="43175" checksum="518F344378005C83" modified="2016-11-02" version="1">MATAKGLKQILTKAPTDVVILSSLRTPVTRAVKGGFRDAHDHELLMHVLRATLAANPNLDPAKIDDVAVGVVLAELGGSKAARMAQLHAGFNDRTGLHTVNRACSSGLQAVTNIGNSIAVGQIDVGVGAGMESMTKNYGSKAIPVNLWDDLRNSPIDNARDCIMPMGLTSENVAKRYGVSREDQDAFAAESHRKASKAQKAGLFDSEIIPVKVKQTEPEHSDMPKEVVVDKDDGIRHDASVEKMAKLKPAFSKDGSSTAGNSSQISDGAAATLMMRRSTANELGLAKSIIGKWAGSQVAGCRPDEMGIGPAIAIPKLMDYTGLKTEDVNIWEINEAFASQALYCIRKLGLDIEKVNPRGGAIALGHPLGMTGTRQLATLLPQLQEGQVGVVSMCIGTGMGMAGLFVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRA5</accession>
    <name>A0A1C1CRA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08741"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09676"/>
    <dbReference type="OrthoDB" id="4157873at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="375" mass="42311" checksum="43C7CFCE6011B03F" modified="2016-11-02" version="1">MATRMSGLDMRAYYSEEDPYLSRSYSQNGKHAASGTFGAKEAGWERCGAEVLTPAQPDNETQDTKVDGWEILGQNAQKSVHLDVLGIYDHTNADDKAASPGSKSKPNDVVKCKTHPATRRLDTNKAWEIVPHEPDWDMVNRKETREARRATKPDAPLAKDWVMYEKGMDAEADTFEGRHCWAEDPAPSTRQSETAMHEPRAIQTEQGVTPSLTFETTEPVFIRSCDRLLDSQEQQPQAQARAIQTTPVEKTQRMPQKDHHSCLVLSGRPTGYASKHNPLKQRPFSAEEKVLPFLPPPSPSQAGTAQAFASTRLDYPEIVRKLRAASITSRESFEQNAVAAVRETARRTDERLARTERVPFDWYGINYRANPRRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRF3</accession>
    <name>A0A1C1CRF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_08036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRF3"/>
    <dbReference type="STRING" id="86049.A0A1C1CRF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08036"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09705"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="780"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="519"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT51072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="822" mass="88954" checksum="3E9CB9D05234A9D4" modified="2016-11-02" version="1">MGNTSSALRAQANNGESSEMVNDQNANETRIGDAGTERGGSRLARRNTQPLRAAGHRASTLYDTFRRHRSADSMSSSPNAGHPTPSPSEMEYEQENRPLVATGDVDMGDAGPTPIVSPSPIRRRSTMSRLGARLLPDAVARGLLNSGEETAEEGRALRHGLSGRLRPSVYERQPNADGNSRLSLAGSIRRRGDNRTESRRRPIRGPFPLLQTTSGAGERRGSFDDDGDDDLRDMPSLATAGLRHRNRFSRARDSMSISQRISSLFRQSSEQLQSAQSGRESPVRPPRVTFADESDHLLLSNASADHRHEHDEAPHELDAVEPEARTLLPSPRVTSGMSTIRRFQPGLRSRSTRLIRRGEHPPLSQVLQLAAAAIAAQLSGHATAGSTGGRHLGGDTFDGSIQNFVQTLQDAATAQAGENIDMNASDGDLPPVNFMRVFQFPNDENGSPIASQAQARDVDQMDLDSITGPGDNDRSVTLVLVGVRSLPHGSDASGGENGTLGPSLDTLLSLPFLPPANVLRNGSSGALFRRSDGRNRHTARRHSMTNFSFPAQYESQRHQRTRTHNSRLSSHSDQIAPTTPDAGPGSTLVSESPPGPHPSPSTPADIRSGHATPIRRPSSASAAANQTLSDLDEDRPQQELDNPPYETSFNAARQRRRSDSEFARRPELGSGAARRNGMVEPDPPPAGAGRSWLIYVVGTNVSPDHPAFAMPSLFTDNPSYEDMQMLSTLLGPVKPPVATQEDVSAAGGVFRLVVHESGLLGQPVTEDNDSSALALNLGERCLICLADYEVSEEVRRLDKCKHVYHRECIDEVSRPMRMPKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRF8</accession>
    <name>A0A1C1CRF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative C6 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_08047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRF8"/>
    <dbReference type="STRING" id="86049.A0A1C1CRF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08047"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09706"/>
    <dbReference type="eggNOG" id="ENOG502QW5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5278208at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="85"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="708"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="719"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="768" mass="87234" checksum="98099FE30BE672A7" modified="2016-11-02" version="1">MNGPYDHGMNMPMPSIMDANYPIYNGTFGTAYPRMSGPPTHFDGVAFWYNPTATEQLYDREASLFNARGVAIPVAGMESSGVKHRRTRSGCFTCRGRRCDETRPICDRCKKGGRECEFPQPTSSSKRSKHGESRSAREQHGKHSIKEENMTDLPTIKDESEEEDETSMSPTTRRPVAPVRSDSGQSMSQSTKSKNVSETSSNFKDQTSPQSSETSENRSRDDTPASSLRTHANSAEMQARQAKIKSLKPDLQRYLQFQQEYMTYYHYFYKLDPTDFVHGEFIDLALSYEPLLYAAVGFAAYHYELQQPDPRLSHFLGYHSKSLSMLRKSLEKSAKVTEATLLTVLQLATFEEYIGDWVNLVGHHRAALAMVHEIFTPAAMMETDLGRRIFSWIARLDIMVGLMAGNKTRLERKWFEANAAWYGSQVDPDPESDVDIENTLAYFVSANRLIGMDMAALFARFANRELSVEEFHRENTEISGRVDSMKRQIELFNDDYYRVQEFPVEKRRPLTADDIVNPYVPGGLFKEELWPLNFMWIDWYSIEQLQRYQTAVMLQKPVPPEVEQISLEQCRIYEAMERWPDAPNGAILGAHAPLGLATVFLKKDARHIMWARRKFAAVERQGYIFPPSFRQRMAEMWGLTREAVGENEAVENWWLPNDEGNIAMLKEIRKVVKERHENDATPGVESIADVRDLKAIFEKLDIRTQSVHRAGVADDHSPLSETSGAASDRGSNASFSPTSVSFGDTPKASFSGDMKAQKRRGTRSGSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRG1</accession>
    <name>A0A1C1CRG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">penDE</name>
        <name evidence="2" type="ORF">CLCR_08775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRG1"/>
    <dbReference type="STRING" id="86049.A0A1C1CRG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08775"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09726"/>
    <dbReference type="eggNOG" id="ENOG502RY9N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="1">
        <location>
            <begin position="108"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="346" mass="37548" checksum="CC3AF1CFB4A39358" modified="2016-11-02" version="1">MPVKHIQCFGTPYEIGYLHGQGAKTEVHGSIAFYGAFFKERTKLAWSEVRDVASRFVPFIESAYPEYVEEMHGVADGAGVDLESIVALNVRTEIAYGMLSDGCTALSWKTSDASFLAQNWDWNYEQTPNIVCLSIAQPPRPSIHMMTEGGIIGKIGLNSAGVGVTLNAIQAPGVSYDKLPCHLALRTALNSASKEAAADALRKTGVASACHITIADSSTGGIGFECTALDIIEMPMETDGQLAGTCTHSNHLVKKHKVEGTLFLNDSPFRLDRIQELMRTVDKPSVEKISEMLKDDKNCPTAINRAVGEKSTSQTLFSIVMDLGKGFARVKMGRPTEDGEVFELKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRU5</accession>
    <name>A0A1C1CRU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_07990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRU5"/>
    <dbReference type="STRING" id="86049.A0A1C1CRU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07990"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06844"/>
    <dbReference type="eggNOG" id="ENOG502QQWX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="729"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="820"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="729"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="825"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="870"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="940" mass="107072" checksum="C389FF2E178708C8" modified="2016-11-02" version="1">MFTCDACLRRALFSLGGPSRTAPRFTLQPLERAINPTNSFSRSHATLESLRKGHHRHSLFEALKDRRRKVSVPKVRPSNPRSRFNTRHAEAVENNRLKRLEPDAREKYLKRAMRQESKYLVDPLKLAQGVVEKLRDHQFDEALELVRASEKSRDGKGVENIVSWNHIIDWLMSQDSPGEAWKVYNEMKKRGHKPDSHTYTIMLRGYRHNVKKPNAVQQAMSVYDSISAANSAVTPTTIHTNAVLSVCARAHDVDAMWKIAGRLPERGPGAPDHVTFTTILQGLNGEAQKRAIEQGARAGPGFNPQPIFDQVIDDARKLWLDITARWRRGYLHIDETLVCAMGRLLMLSDDKQTQKDVLSLVHQTMNIAKMSQAPDAERQDDAQEDDEVGRDEQRPSTIDAPARITPRSDPSARQVSTTNSSVYATPGTNTLSMLIETATALRELKLGKYYWELLTAENGSYKIVPDHQNIMAYLRLLRVSRASRAVLDVLREPRPEEVNHKLMVRGTFIIAMSTCLRDKKNPNVFETASRIMDLMQESTEDMSGRESEEDADGQRLRFSPKVLRMYLEIAIATTKGINGEALEKTKNGDLDFERDPSKNPTMRALRRLSPDIMNVRQMIKSYLIDIEQQASIQERTIRVKKLLEKRKITPYSTNENIADLIELLRTMIGAIDKIILVNEKLEDEGMGPLDKEILNECWLQKRKLSAFVSKYANAVVEPRNPSEIRARRVNEQGHRLSRRHSQEHIEVDSVAEPTKQVDSTDDDLTDPSVPAPSPRAKILSDIQSAQEKVLKKSEERGLSRRQKLELLKKETTRAQFPASMLRQQETPRRVLRKQDTKAAARERTREMLESGSGGERKVPVWKASQAARTLSRETRNERRAREKEDRRRRREEVERGETAKGDRMQSQKETYRGWGGGFEELAKEEGGNLGEKAGVIELGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSM0</accession>
    <name>A0A1C1CSM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_09031</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSM0"/>
    <dbReference type="STRING" id="86049.A0A1C1CSM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09031"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06604"/>
    <dbReference type="OrthoDB" id="4113238at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="114"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="228" mass="25828" checksum="01B3A31472072388" modified="2016-11-02" version="1">MTDYHSTNGWSQQSGSFSPMDTSFQWDYAGVQSPKNMVSHYNDRAADFYATLDNSFDSMSSSGSDRSYRSTPERRTAPTTNSVVAQVKGSIPDKIEVSSELQPSFSRVTGLTTRQRRREQNRSSQRAYRERKERHQKELEGQIAQWQQKHQLLSRSYSQQTAEVARLKSQIEQLNSEISNLQSGLPTLCGSLCQSPQEFDLVPFFKADSLSPQSTPRMSHSTPSRRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSZ9</accession>
    <name>A0A1C1CSZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 9a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">vps901</name>
        <name evidence="4" type="ORF">CLCR_08111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSZ9"/>
    <dbReference type="STRING" id="86049.A0A1C1CSZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08111"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06510"/>
    <dbReference type="eggNOG" id="KOG2319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14369">
        <property type="entry name" value="CUE_VPS9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041804">
        <property type="entry name" value="Vps9_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="390"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="693"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="738" mass="81346" checksum="40483175584AD7C8" modified="2016-11-02" version="1">MDTEQKTVPTEIPEPNLIDLDPDTDTGGVVRTDDSSGDVLSERASEPGTGAAEKIHRLEINDPTADSNHGPSPKLLPSTPPPPEPPAASEKPYLDPTPKTPAISRHASVRLSEEEYNEKDPAYTPETEDNNAELPDQKPGNDPDVESTSEIQSIMDQFDDETAAPSKESIMSPRHEMTGPILGSTSGFPPRRSSLEHLRSRELDTVASPVISHHSEKPLPSPPQDALNHESGPLRSPPLKAPGQASTTSLPAQPPPPEPEPELPFDFHRFLEQLRHKSADPVAKFLRSFLTEFGKKQWMVHEQVKIIGDFLAFITNKMALCDVWREVSDNEFDNAKEGMEKLVMNRLYSQTFSPAIPPPPQLGRSRSRGRRKELEKSSVPGRRGQHQEDVERDDILAQKIRIYSWVREEHLDIAPVGPNGERFLKLAQQELLKIKGYRAPRDKVICVLNCCKVIFGLLKNSKSSDTSADSFVPLLIYVVLQANPENMVSNVQYILRFRNQEKLVGEAGYYLSSLSGAIQFIEGLDRTTLTVSDEEFERNVENAVAEIAEQNRQNEQLSPIAGFAEKSSVAEPELTPRNSMDVTSRSPIRRDPNRHNTSSGDGSDDSVAGLLRTIQRPLSTIGRIFSDQDTSSQERRPSPNPAPRAPPRLSPSVFQPPPSQAQAGAVPSYDAQEAAARQASAEAAEARRISRVEHRTVVDTLCGMFPNLDKEVIDDVVRQKEGRVGLAVDACLALTAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTC3</accession>
    <name>A0A1C1CTC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative AAA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTC3"/>
    <dbReference type="STRING" id="86049.A0A1C1CTC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08095"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06359"/>
    <dbReference type="eggNOG" id="KOG0733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000081">
        <property type="entry name" value="AAA family ATPase/60S ribosome export protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000365">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="186"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="515"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="751" mass="81367" checksum="47F9D95D79D9B9BA" modified="2016-11-02" version="1">MSQVYQVVRRIIDERAQYEDGPPERLTFAAVYDEIRRSNSSLNRRPKKLLEDSIERVLVTLQQDSESDSDASIEVAQEERQKHKSASNNLNRSIVSAWANSAAPSGSVTPKPELAAMESPAKPAPVVNGEPPRKKRKAAPVIDRSPPTGITWDSLGGIDPVIQQFEDLVVIPMTKPEIYAEHKVQPPRGILIHGPAGCGKTMVAHALAAELGVNFINISAPSIVSGMSGESEKALREHFEEAMRCAPCLIFIDEIDAITPKRESAQREMEKRIVAQLLICMDDLALEKTDGKPVIVLAATNRPDSLDPALRRGGRFDKEINMSVPSEPVREQILRAQTRGMSLAADIDFPLLAKRTPGFVGADLNDLVSTASATAVRRYLNQLKANSEKYTMDVDMDAHNAHANANANGTDTLPDLIASSSSETIRSFRRLVNYAKAAHPEDKDTNEAVLLITFADFLTALPQIQPSSLREGFATIPSTTFSAIGSLKSHITELQETVIQPILNPALYSSLGITPSSGTLLWGPPGCGKTLLAKACANASHANFISVKGPELLNKYVGESERAVRQVFTRARSSVPVIIFFDELDALVPTREGGSGGGSEASARVVNTLLTELDGVGHSREGIYVIAATNRPDIIDPAMLRPGRLDTLLYVGLPDAEGRVDILRTLCTKVAGMVFDDSVATIAEACDGFSGADLESLVRRAGYNAIRRGVASGQTVAITPADFEHARNEVRRSVGVDDIKRYAALQKHWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTH4</accession>
    <name>A0A1C1CTH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenylosuccinate lyase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTH4"/>
    <dbReference type="STRING" id="86049.A0A1C1CTH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08543"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06317"/>
    <dbReference type="eggNOG" id="KOG2700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01597">
        <property type="entry name" value="pCLME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF2">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="2">
        <location>
            <begin position="374"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="468" mass="51950" checksum="2CC79ACFD7A82683" modified="2016-11-02" version="1">MTSVQDSVIFGNILSTHESAAIWSDKTRTQCYLAFEGALAKAQARLGIIPQKAADAIIAFCLNIRNVDFDELRQQTELVGYPVLGVVKQLVRHVNGVEPGLGEWAHWGATTQDVTDTATVIQLWDTLSLFEKQLDAIIASLRALADVHKATPMAARSNLQHAVPMSFGFKLARLLATFLRHRERLKDVETRLTVLEFSGAAGTLATLPPSVDEPLLGLECQRELAKDLNLKVPEIAWHTERDRFAEFGSLCAMLTSTCAKFALDVKLMMQTEVAEVSEPYVPHRGSSSTMPQKRNPISCAYITAMAATVRQLSTSLFEAMVEDHERSTGPWEIEWIVLPQISTQTHASLKQTAELIAGLEVHEDAMKKNLDISKGGIVSEAVMTGLGKTLGRQYAHDVVYDLCRKSQVENRQLLDLLCEHEEISKKMTREELATLCDPAHYLGYSEVMVQRVLKLADEPRMDRPASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTJ4</accession>
    <name>A0A1C1CTJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTJ4"/>
    <dbReference type="STRING" id="86049.A0A1C1CTJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09064"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06311"/>
    <dbReference type="eggNOG" id="ENOG502S22D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425354at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="199" mass="22262" checksum="66E2F9D5D479D6EB" modified="2016-11-02" version="1">MAAPPQITCTNLSGKFALNRSLSDDVDAMLELQGVNWAIRKVISLASVVLSVKEYTKDSTTHIDVTTVVAGLDKTQEDRILNWQDSEHGDKIFGKCRHRSRLVKVSEYILEGPGSAEDAAFLKGEKLKDGRIDSHFEVDEVVQSWVESTGGAGWKCEQIWAFETIAGERRYSRRVVIWNAAKVVRTRIVYDYKGDGKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTL4</accession>
    <name>A0A1C1CTL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipid methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTL4"/>
    <dbReference type="STRING" id="86049.A0A1C1CTL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08915"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06294"/>
    <dbReference type="eggNOG" id="KOG4300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="281" mass="30379" checksum="BF7211E8B877A417" modified="2016-11-02" version="1">MTAAAPTMAPTTLEYIKGMVFPLPFMGASAFFFGLTFVKNPLLPLRDLESFKEKAFANLWLTFGPMCADDTPESLPPLLAQSKGVILDVGPGSGEQVKRFTHPENITAIYGVEPGVSLHDKLRDKARAAGLGDKYHVLAATADLDAMIPALIKAGLIQEGKTSSTDLQLFDEIVCLRVLCGVPDQAASVADLYSLLKPGGRFVVCEHVLNTGHWVARLAQQFYMLLGWKQLMGGCCLTRNTMDTFLKVANARDGGWAKVEVTQADELSPVVHVVGVLTKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTV5</accession>
    <name>A0A1C1CTV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09346"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06226"/>
    <dbReference type="eggNOG" id="ENOG502QRJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="91" mass="9955" checksum="5D4A9E3D1C2A3455" modified="2016-11-02" version="1">MLSSLVRNVLSARRSLERRLRARWPQTQGKAWETLQKNGLLGFICFGGPPVHFQIVSVSYNWDLALATSTAAAAALPSTLVARPRSDFAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUN0</accession>
    <name>A0A1C1CUN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">alg14</name>
        <name evidence="12" type="ORF">CLCR_08867</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUN0"/>
    <dbReference type="STRING" id="86049.A0A1C1CUN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08867"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05975"/>
    <dbReference type="eggNOG" id="KOG3339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT52180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="322" mass="35208" checksum="2FAA400AC3F5BB50" modified="2016-11-02" version="1">MDDPEAPLLSTVPPTWTTILTPITSLSPLSRLLLFALVFTLILINFCFFRLAAVLNRDPIYRRPRSPSDNPPHLLIVLGSGGHTAEMLNILGQYRRLQHDWPQRTYVVSSGDDFSASKAREFENNMSSKLDKGDPSGGGDPALLVGPTATGYDIITVHRARRVHQTLLTTPLSSLRCLWDCIKLLRGTHPDFCPRIAGDHSSRPSTPDLILTNGPGTGVIVILASIILLFFGVAGPSASLPRSKKVMKHDTGVGDASANRIGQMRSIYIESWARVRTLSLSGRLLKPLVDRFLVQWPQLVEKETAGAGARTGRVEFVGSLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVV6</accession>
    <name>A0A1C1CVV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09565"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03968"/>
    <dbReference type="eggNOG" id="ENOG502S16F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF3">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="902" mass="101876" checksum="0A232A8581FBDD89" modified="2016-11-02" version="1">MDHLVLPEGVKPWIQVAYEGQEDTYYDKDCGNFFDFYKTRGWTPDDVKFQPKPSENLLGGVVEGEEEQARSAAEVETFFQTWLFFGLIIEVFALSEIAVTTQDFLVPNTLKTVHKPQKGQLITTAKLPSLIAKWRQTSSRDNRTLSEAMKMIDFVGDIVDHHCAGGKDHRSVHQYGKVLWPLKDEVTTSIIAVASTLRKAARQIYNVTGKEERWPVTNSRILYLRIQRKWCKADAAMIMEDLDIDGQYYIAAAESHSLESLDSHYACTDHSCEAKISDGTYVTQHADGCEARDDYEPEPKFVGHRIPDYQKSPASLREAVKHVLDAGHLPVLRWDCEQRGLATYGHERFTYSGEGAMPPYVAISHVWADGMGNPFDNSLPYCQFDRIQRLVDDLCSNHLPEKKRHTSPGFWMDTICCIVGVDNESKKYKSKSITSMREIYHDCVAVLIIEPWLAAIPTTAPFAEIAHRIYSSGWSRRLWTHQEGFLGRDVYYQFKDKPLSFAEVTEAAREYERRMGANGYPITFPYAAASKTSFYYTGIKNIIENIREGRFSKDDRWIIYRHLAESLGHRSTTNVDDELLCVASVIGLDVGDYIKHKDAEDNRERTAELRMQAFLEELGRFHQGIIFNNYRRLTTPGFRWAPVSLLGHRASGLGDIDGSTDSRVEDYSTLPMDDKHVELESMGLKVKINLTKHLTKTLGLNKRFVSIVLNDKTVKLPTVGLPVDYPGYTIKFPKGSGLTIDMAERRFVLKYSPIPNPMPAVTTPPPLPKAPSFGKVPTVKGIRGFGKASEQVNQQVEKAQVAANNLAETVTYQYVVYVAENEVKWEHDRAYAIILQRPLGDSANQEFLAMIGLNSIGPGPRTFVQSLCSAVVRLVGRYDSYKVTAGLDVVEVGKPKTNWVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWI7</accession>
    <name>A0A1C1CWI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiprotein-bridging factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mbf1</name>
        <name evidence="9" type="ORF">CLCR_10848</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWI7"/>
    <dbReference type="STRING" id="86049.A0A1C1CWI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10848"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04253"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="111"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT52912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="179" mass="18740" checksum="1EC189CE884CE6D2" modified="2016-11-02" version="1">MSEDWESVTRIGSKVRGPGSGGVDRERVVKGKSALNAAQRSGAIIGTEKKYSSANTALGFGSGSSSGFNFANSPSTAGKKSATEGQHLTKVDRSDEIIKPKTVGHAVGQAIIARRNQILPKMTQKDLANKVNTQASVIQAYENGSAIPDQQLLAKLERVLGVKLRGSDIGAPLGGPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX80</accession>
    <name>A0A1C1CX80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_09882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX80"/>
    <dbReference type="STRING" id="86049.A0A1C1CX80"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09882"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00107"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF4">
        <property type="entry name" value="CYTOCHROME P450 98A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT53134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="564" mass="64439" checksum="10448A439DBAC13C" modified="2016-11-02" version="1">MGVLQNLSSAPGTLNVALDTYTLIRAVLIGVVAVPVLLVLVDYVRVLRIRQRLPPGPFPFPLVGNFFQIPKHKPWIEFEQWSKHYNNPMFTIWQGHRPTIMCNDVWTISDLLDKRANIYSSRPQMIAMGDMINATESNQVCLVYGDKWRHHRRLMHTATGSQAIRPWREIQANESKILVRDLMDRPDDFVMSIERYSCSIVSIIGWGRRIDKINDYVAQMALKAMEGVDLIIPGLFLVESIPILNRLPAWLSWIYPMPRQAFKFAQHMQRYFVALSKEGAQMPEDNFAKRLFQEQEKNNITDEEISTLTSNLIGGGVDTTSGTIISFILAMCVFQDKMKKAQEELDRVVGQDRVPDWSDEPNLPYVKAVVNETLRWRTVTILGGIPHAPIQDDEYHGYLIPKGTPITGNVWAIHRHPREFPEPDNFRPERFLNGLERPYPNKQGHNAFGWGRRVCSGQSLAEQGLYLTIATLLWAFDFKPGLDENVGACSSLAGDTANLIQGKEVKLDIFAYTKSENMRPEPFKARFTPRTKGIEEILRREAARARKELCAYDGETRLTMENVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXV2</accession>
    <name>A0A1C1CXV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_09669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXV2"/>
    <dbReference type="STRING" id="86049.A0A1C1CXV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09669"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00316"/>
    <dbReference type="eggNOG" id="ENOG502QVIM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06421">
        <property type="entry name" value="CESA_CelA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF2">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT53349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="719" mass="79447" checksum="DAF8F48701DF8D9B" modified="2016-11-02" version="1">MADPERSILRHRGPKKDKTDTLTGGTETSSIADGVEDHITVVAPTGTESAATVAQPQGEDTGTIDFDIDEEFNLPPVPPNTPAEANLPVIRDYAVVTSSNGEESLVWHATAAAYLDGVEMIEQEKADPVTLGTLLSDALTPINVITTVIYLALLCANAKSSKLISPATLFALAQINENLGTITEGLWKTVITLARNRSPRPSLRLLGKNVPSVDVFVVCCGEPDDVVLDTVKAACKIDWPTSKFRVIVADDGNSLNLRNKIQQMQGTYTNLHYYSRVKPAVGHHGYKAGNLNATLLDYVEKTPAGYSEYCAIFDADMMPEPNILRMLVPHAIKDPNLAMVTAAQFHYNVPNDDPLNQGNTTGTGAEDGNRDRVNAAWCPGSGFVLRTAAWHDIKGFPEFSITEDLITSWCLHGKGHKIALIPGVMQWGLQPDCLITHLKQRRRWWTGHIRDALRYNFTLNAEALSGASLIQRYAMFHHACRPYTMTITHTINTLLTLLCLWLGGPVIGGSDIRGLKQIVYCLAISRVIGLIGDVKSIFSGSYLKVRRMIATGVWMGHHFSRDTLQTLLPQRLGGLRLGFGVSGVEDKPQIGVKERDVASRPALLTRVWMVHQREGILWHLALFLVTVALVLYRVMGVFNTSTVNGQVILSNDFWTELVKSVGFPGLALIDNVLYYLTPIFYMIDPPTMPERRETMKYDADTGLWKPREEYKKVLYTRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXV9</accession>
    <name>A0A1C1CXV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeodomain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXV9"/>
    <dbReference type="STRING" id="86049.A0A1C1CXV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09955"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00326"/>
    <dbReference type="OrthoDB" id="2240312at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000500">
        <property type="term" value="C:RNA polymerase I upstream activating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039601">
        <property type="entry name" value="Rrn5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="65277" checksum="3ECBFB786F3326A5" modified="2016-11-02" version="1">MDLDDSPDESDDQGHVSRDGDLLHDEDDEDDSLNEDEHEHDHEHADARTHALEARPTARPDIARSVSFPQRKWNRLRKHYRDHYLVLFKNTFEAGEDDYFHGDLSPTQLGATLWQPDEKTNFYRALRRKGRHDLPALAGLVGSKSVVEIKAYLDNLRELEADRQRFEAQPKNVAHAEIPAAVEVGPDCEAILNRAADALLAFQEQYDAAAAKESNGMWLIDHEIAAELDERADDSEMQGDAPDLASDDDASPIPQRACSFFHLSAYLELSERLFMNRGSNSPDSWQNVAEEGERPSITLDCVTLLYDIIVNLLRRLVQSCIFLAQSRLRASTTKEYRPSGSVKFEDVAAALDVLGVRRNARSYWVGLARRNGLRIVDDAHRRGVDGKAAIPYGAVEESLSQSGRSRSVSAARGASSGEDEAISESSSPMESEDSSRDHSNDHSNDEEDDVQGSEGEVSHQQEGDEDFRDGTETEHDAPGSEGRSKVAISRHKRFRLLEEQQDDYLERMDKAARRREESRLLSFLGAEEHEKVKEEDGVDLGVRPRRLRKSVADCMGWSSINFEAEWETLAKRRRLDSPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY00</accession>
    <name>A0A1C1CY00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-carboxymuconate cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY00"/>
    <dbReference type="STRING" id="86049.A0A1C1CY00"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10272"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00342"/>
    <dbReference type="eggNOG" id="ENOG502S2T1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10006285at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651189" description="3-carboxymuconate cyclase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="41611" checksum="2D5829E7C9DC516C" modified="2016-11-02" version="1">MQPRSITALVGFAALLTCGHAVPPQRHGSSFKHHKAAQAIYLLTNDASNAVAAVPIGADGMLSVGSLTPTGDNGGNSINAASGEPAAPDALFSQSSLTVAGNYIFAVNAGSNTLSMLSINPRRPTELTMIGQPVGLPGDFPVTVAASAKNGLVCVGSTGTANGVSCSSFAHTGLGPMDELRSFDLNQTNPPSGPPNTVSQVFFSEDESRLFATVKGDPGVEKPGFFSVFAVEQGRKWHGTSKLSTEETRSSPEGMLVLFGSQDIPGTSNVIVTDAAFGAAVVAVDPSTNTASTVARQEVVGQAATCWVTISSATDTAFVADVGVNRLVEMSLTDASIVSTLDLSSNGDPGLVDLTAAGNFIYALSPGNGTTTAAVMVLDVSGGPGSAKQVQHFDLSGMGVGKNAQGMAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYR6</accession>
    <name>A0A1C1CYR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Noorani M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYR6"/>
    <dbReference type="STRING" id="86049.A0A1C1CYR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10502"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00594"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="14"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="335" mass="36674" checksum="9FF5D258CFCB8AB0" modified="2016-11-02" version="1">MATMRAVDIKGGEGPISSLFINDQIPKPTPKGSQALVKIKAFGLNRMDLLQREGKYPLPPQAGPIMGVEFSGTIESFGAEPERGFNIGDEVFGLAYGGAYAEYIAVSTHMLVHKPKELSWEEAAGIPETWITATQALYLVGEFKPGMSVLWHAGASSVSIAGIQLCKADGASAIYVTASTREKIEFTKSLGATEGFSYKEGDWAQALLKHTDGKGVDLIVDFIGAGYFDQNLDAAARDAHIVNLGNLGGNVVQKPVDISRFLRKRLRYEGSSLRSRDEKYQGRLRDMLVEHALPRFIDGRFKVIVEKVFKMEEIQEAHKLMESNQTMGKLICTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYR8</accession>
    <name>A0A1C1CYR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Inositol phosphosphingolipids phospholipase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">css1</name>
        <name evidence="16" type="ORF">CLCR_10106</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYR8"/>
    <dbReference type="STRING" id="86049.A0A1C1CYR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10106"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00591"/>
    <dbReference type="eggNOG" id="KOG3873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052714">
        <property type="term" value="F:mannosyl-inositol phosphorylceramide phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000059">
        <property type="entry name" value="Inositol phosphosphingolipids phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT53642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="503" mass="56550" checksum="FF8967DF497BC235" modified="2016-11-02" version="1">MASQSLAADKESGVSKINILTLNCWGLKFISKYRRERLSEIGNRLATYTPQLDIVGLQECWTYHDYLSIRDSTRSILPYAKFYHSGIFGGGLAILSRWPIKDSSMQRYPLNGRPQAFFRGDWFVGKGVACATIGLPGGVNIEVFNTHLHAPYEREPNDSYICHRTAQAWEIAKLMRAASDRGSLVIGLGDFNMVPLSFAHVLVESRAGVQDVWRAIKPASSIGASIDAPEQERRKRMKEEETPTVETSLQEHGHTCDSVLNTWRWNKGHQKELARGHDRKVLASDLDPKAKRLDYIFFSGIGHGWKVADVKVALTERHPTLLCSLSDHFAVQATVERSHTEPPTIAQVEAHAALNDTDTQDPSLEVADFDDKDFDRAISALPTRGRVSQDFYKDILRMVERYKVRERRQRRYGVLHFVGASLASIGCFVAVWWSPRNYVAFILVLLSTFGIMAGTLNGLIGGFFVGTELRALAEFEWEVRNALYLAGGPVVDDRSLAVKDWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZE2</accession>
    <name>A0A1C1CZE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Maltose permease MAL61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MAL61</name>
        <name evidence="13" type="ORF">CLCR_09834</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09834"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00833"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000254">
        <property type="entry name" value="MAL31p Maltose permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="105"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT53919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="603" mass="66732" checksum="37E76E63B898B28B" modified="2016-11-02" version="1">MSFAHDEESGPGRSGRHMSVSHYANNMGAPTYDTTRRRSSIVPAAALGAQQDEIVFNQKDETLRKMSVAVPNLAELSADARAAAELERKMGFREGCRLYPKAILFSFSLSLAVVMEGYDTYLLGNFFGLTTFARKYGSPAGIVDGVQTYQVSASWQSALSNGTAAAQIIGLFLNGIISERIGYRWTMIGSLIFITATIFITFFAVNVRMLLAGYVLSGLPWGVFQTLTTTYAAEVTPVPLRPYLTTYVNLCWVIGQLIAAGVLKGFVSATDQWAYRIPYAIQWVWPLPIALAAFLAPESPWWLVRHGKLDQARAALLKLTSKKNTEFNVEDTLAMMIHTNELEIQQTAGTTYLDCFKGVDRRRTEVTCITWLIQQTSGSPMIGWGTYFMIQAGLSEANAYSLGVGQSAMGFCGTVLSWFLMPHFGRRTLYLWGQIVMFVVLVIIGGLGVPSLSTSVGWASGALILILTFVYDFTVGPVCYSLVAELPSTRLRIKTVVLARNVYNIMGIVVGTLQPRMMNPTAWGWRGKTCFFWAGLNLLGLVWSYFRLPEPKGLTYAELDVLFENKVSARKFKTVKVDPYRSDNLVIVPDDEGDYSVAEKKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZL2</accession>
    <name>A0A1C1CZL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_09780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09780"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00893"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="13"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="514"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT53989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="554" mass="61458" checksum="C24D843128C4B9D3" modified="2016-11-02" version="1">MGKLIPNAFNLAVVIFVALGSTACSYGMAIIGSTIGQPSFYRSLHLAPQGEPGYGRTAEYIGAFNGTLLDLIRPHSEWLLTFLQPGVNSAGSAIGAAACAYCADKWSRKHTIQVAAIILVIGAAICAGSVNNAMFLVGRVINGLGIGALVTAIPMYQAEVSTPESRGFMVSMHGVMFAMGYTLSAFIGFGVSFISSGGSPSSFPWRFPIAFQMVPALLLLIGSPWLPYSPRWLLMHDRHDEAHEVIKRLHRTKNDTHDSLARKEFYQMKKQVELDRQISATTSRWEIFKTPANRRRALVGFVLMWNNQFTGVLIIANYGVILYLQLGMTDFWPLLLSAFWVLSTFPGNIFCAFFVERFGRRRFLLIGLTGILVCLICEIAIQATYLGTDNRVALNFGVFFIFLFITPFWSTFIDASQFLYVSEIFPTHIRSQGMAVSMCGMYLADIILLVAGPIALNNIGWKFFLVLIIPTALHIVFVFFMCPETKGRSLEDINAQFGEQVAIHYYNATDAEKEELEKAAQQDEEEEAQKTRTSLGEKTAEDVEEREIIAANKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZU7</accession>
    <name>A0A1C1CZU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11031"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="117" mass="12543" checksum="F04271A7694790CB" modified="2016-11-02" version="1">MPTPMNKGQPSRNNPYLACRATVLPLLYPVVVGESGDWSFGGASLSCVCRYRATTSRQSRRGRRTPVLAALGGMSKGAVISALGFAGCLRRLAATECAQTERQDTSWRSEAVAMFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZW0</accession>
    <name>A0A1C1CZW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09786"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00825"/>
    <dbReference type="eggNOG" id="ENOG502T517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4150142at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="653" mass="73357" checksum="BD0ACBD55DBACDBD" modified="2016-11-02" version="1">MAPSIVNQSAITTKCGYSSRYLPNLARSPVKRNALRKSASSEKGANAALEAERGKGLLLRSWADVAQGSERTRCPQTRGYFIPQVAEVQHSSVRYPTNHLLGIPQEVRDAIMELLHPAEEAAGTRPVAGYENYQLACRQTFHETSRRWNYQPTVLVPFNRALEFITRTLNAAVLHSNAYHNVKSLFLEIRHDASSRVFSQMAQVLRLSTQLEELHLFGVGPDGYGVSTSSVAHSCGKHDMSIVPLKSKLHIDGQHYRRRLTLVNGIPWLQHLKVLVLDNLNMPLLQAHVLMNKPRLQKLYVSADPRSAMHVEYKGCRSLGLGNLVWPVNGSMPPVKELRVDANAILTASQIALKVARTLESLEWTIPDAAFQLHAGQISFYSEATQVLSRMPPEARRLRELRVCVHGPVSEDNHQSGNLMGSFKDCVSRMPSLELVELHIHSKSLWFANEFVEALSPSVTRLYLTDLCVDRNIRELCDSVSTKTGVDAHHLEEVHKAVAIGEDLMRQDYISFSGSRLGFVGYEYDLNLDVKAAAKQGEDMSMFLKLNGRLLDRERNRHLASFEGMFIPPEEVPVEEWLEGIDLQSATTHEQVEKNRNELAGCILDDHHEYFGSEDVAEVVFRHEPVAKGGHYSYPVISEVQNLFKGSNHWLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D057</accession>
    <name>A0A1C1D057_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_09887</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.67" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D057"/>
    <dbReference type="STRING" id="86049.A0A1C1D057"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09887"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00911"/>
    <dbReference type="eggNOG" id="KOG2283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14497">
        <property type="entry name" value="PTP_PTEN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="6">
        <location>
            <begin position="47"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="63"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="477"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="585" mass="64665" checksum="AB39EB147816FCA8" modified="2016-11-02" version="1">MSTHRSTHTVANIRRLHFYDRSSPGRERDSESVGLSVLTAPATLYADKIRSPEAGLDLCYVTDDIWPKKAYRNPLSHLVGFLDRKHGEDWSIFEFRAEGTGYPDSEVYNRIHHFPWPDHHPPPFAIIPNLMASMRNWIQRADEKAGEEGGDNKRRVAVVHCKAGKGRSGTAACSYLISEEGWKKEDALQRFTTRRMRPGFGLGVSIPSQLRWVDYVDWWTNRMGKRYVERPVEVVEVHVWGLRDGVKVSVEGFVDNGRRIRAFHTFTRQEKTVVEDSNRAAKPASGAKKHDQILTSPTNGTPQSSSMSLDSSAEPSSQSVILKPSRPLILPTSDVNIDFERRNKAGYTGLTMVTAIAHVWFNAYFEGGHEGHDSGIFEIEWEAMDGIKGSSRKGTKALDRLKVVWKYAKQEGDGGPVERIITQPEKGELVPEEQPADWRGVDDTEVRPADGVDSGRKGAAALTMGAMINQGATTLGKELGLRKSQPESADVSRASSVKDETTSGQVSSDAQRVEHSEDAGVKPFVPEDEATDAHGATNPEGEGRQDTKTGHRMEAGLAKAALVISKMKPSRDKADKDGEGKKDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0H4</accession>
    <name>A0A1C1D0H4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Armadillo-like helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_00244</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0H4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00244"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10179"/>
    <dbReference type="eggNOG" id="KOG4654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01158">
        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT54252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="633" mass="71073" checksum="94FE62A6C51427CB" modified="2016-11-02" version="1">MMDALLTQQSRPNSFEPKITQLYLHLFNVLANEGVDDAVPSEGFWREFFLLKPDKQRLYDILEPLTASDLMHMQIQMRAFFRRAVSEAGSGVSPSNGNALDNLIAFLCAVFNKKYTNPNTDIIDILAGLDAVDRLMSDLVQGLESIVRQSNEDLLRIKAVETVLALVAGGFQTSLVTYFIHRDLFPALMKYVHDVHESSIHGPRAFVVIGILSSYNKFEAQNVYQNRLEDFVNEETIRLLVLNSAHACAHIRDQYIAVQDDYPAPWTLNSTLALVGLRALTSDAQKPAPPTEEEAKARFLALPEPDAACSLSLYSFVKANNLFATSLLSLPADKDGESPFSAFLSMTSYISHHAYRGPRQATYAVFGLLCIRIIAEDPVLVKKVCSADSKTVFRLCRQRAPHLPLITSARIPATAILDVCTDILSHNLRKRLDVHLYGLALGIILRIVTHLEQTKTRLQHHWAYVWGSLLSLMRFLTQYAEDLGHLGDIRGDLCGTLTSLTAFCLSKGDGFLPDPTSFDDFFYKLIEANDVLLKFKQAYCDRSTQSEKLRSSVAALISVSSHYHDLLQAQHGKKTHQSPAAIQKVIKEGYETLNMEADDSFGEWERWRESGWKAELKKMTRIAVEDARILSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0L1</accession>
    <name>A0A1C1D0L1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">5-aminovalerate aminotransferase DavT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">davT</name>
        <name evidence="7" type="ORF">CLCR_00280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0L1"/>
    <dbReference type="STRING" id="86049.A0A1C1D0L1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00280"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10205"/>
    <dbReference type="eggNOG" id="KOG1402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000013">
        <property type="entry name" value="4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="445" mass="48226" checksum="DE96BDFE814FDAA0" modified="2016-11-02" version="1">MEAQKLAAFGKQHVSPGISRLTDEILEYGAGSYVTTAGGRTFLDFTCGVGVTNLGHCHPKVTKAVQEQAGKISHAQISIGFHRPYLNLIEKLLSIMPHPSLDAFFFSNSGSEAIEAAIKVARRATKKPNIIVMQGGFHGRTYACASLTTSKTIFREGPGMTMSGVFVAPFPYCAHSPEAKCTGGKHDPETCWQSPLRQLELLLKQQSAPRDTAALLIEPVQGEGGYVPAPPEYLVKVRELCEKHEILMIVDEVQCGFGRTGKMFAVEHSGVRPDIMVMAKGLANGYPLSAIVTSKKVMDSMVSGTMGGTYGGNAIACAAAVAAVEVFREEKILENVEVRGRELRAMLDECATAPDTKDIVLDVRGLGLMLGMEFQPGHNYAVRIQDKCLEKGMIVLTTSIYDTLRFIPPLNITEDDMKKGITIIRTAIQEVAAEDRNGAYQNGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0P8</accession>
    <name>A0A1C1D0P8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial chaperone BCS1-like ATPase lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_01008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0P8"/>
    <dbReference type="STRING" id="86049.A0A1C1D0P8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01008"/>
    <dbReference type="OrthoDB" id="4185683at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial chaperone BCS1-like ATPase lid" evidence="3">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT54304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="94" mass="10865" checksum="FDCB8982BA610E0D" modified="2016-11-02" version="1">MTRLFDLVYKRVDRDLDGLGGSVKDNKPESVAGFAEEFVKKVPEREFSPAEVISHLLAKKHSPRQAIDNVEKWVERTRDEKRKVKRVDSWALGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D116</accession>
    <name>A0A1C1D116_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative drug/proton antiporter YHK8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">YHK8</name>
        <name evidence="9" type="ORF">CLCR_00829</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D116"/>
    <dbReference type="STRING" id="86049.A0A1C1D116"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00829"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10107"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="104"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    <evidence type="ECO:0000313" key="9">
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    </evidence>
    <sequence length="566" mass="62434" checksum="9ADB70EAD435DEE8" modified="2016-11-02" version="1">MAERVERPLMSSTSPTSGDIEKINTGHSLASNEEPVPALEPGAHKRSRASPDTQVEDGIRYDYLDFDTHIPLDEFDTIQSSVPPPNLKKYESPLTWSSKHKTIILILCCWCTFTAAYSAGSYSIAANPQRAKWHLGEVAFTTGVTTWATGFAVSPMFLAPFSEINGRRPVFIGSAILFLVGQIACATTPTFGGMLAARFLVGAGASTFATMVGGVVSDMYNAEDRNTPMALYSGSALAGTGIGPLLSGFIIGRANFRWVYYHQIISLSIMLVVVYFFFKETRGSVLLSRRAKVLNDYLEKLETSIPNADSTGEKVDRPVRLRYKVAADESRSSLARMLYLSLTIPFKLLTTEPVVFFFSLWVAFAWALLYMTFSVIPLVFMSRHNFNVEQCGAVFSAIAIGSILATLLSIYQEKLAKKRWPKLNSSPEGRLYFPCLEGALLPIGLFWFGWTTYSSIPWISPVLAIGCAQMGIFVIYLAVFNYLADVYHRYASSALAAQSFLRNIFAAVFPLFTNQMFTNLDYAPASSLLGGIAALLTLVPWVLLFKGEQIRARSKIARQIMGDNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D148</accession>
    <name>A0A1C1D148_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Involucrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="VEuPathDB" id="FungiDB:G647_04697"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="InterPro" id="IPR053268">
        <property type="entry name" value="Woronin_anchor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641:SF2">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_2G08060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D169</accession>
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                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="423" mass="47654" checksum="4C608EFBCB09A71A" modified="2016-11-02" version="1">MQASLPSWKDAEKKQQIQIPWKSLQLLVPHRLRRRLRSKLRNRTSPASSISALKTSFSPADTLRSLQSHRWTIYDGQWLLLAVVGIFSLSIIEYPGPLVKTAVATLLLSSFIFPITRQFFRPFTPIAAYLIFFYACRFIPSEWRPPIWVKVLPALENILYGANLSNILSAHKNTVLDLLAWFPYGLGHFGGPFVVAAVIFVFGPPSTLPVFGFTFGYMNLAGVMIQVLFPCSAPWYENMYGLAPANYSMKGSPAGLARIDALLGFDMYTSGFTASPMVFGAFPSLHAATSTLEALFMSHIFPRYTPLWAFYAAWLWWSTMYLSHHYAVDLVAGSLMAGTIFYFAKARFLPRLQPDKRYRWDYDYIEVGETQNDYSYGIAGLHGSDPDSDEWTIGSSSSISSGSLSPTEESPKQWTEAYSNHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6W6</accession>
    <name>A0A1C1C6W6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lactose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LAC12</name>
        <name evidence="10" type="ORF">CLCR_00573</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6W6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00573"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01135"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF66">
        <property type="entry name" value="MFS HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="42"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT44211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="535" mass="60343" checksum="1EE25F072504ADD7" modified="2016-11-02" version="1">MVGIVAVQPAHKVEREVAVAEAPELRRVIWYKDPGLRKLYGLAIALFFASATTGYDGSMLNGLQILPVWQDYFKHPTGSLLGLFGSIYSIGSLAGLPFAPYLCDIFGRRIAIMAGCIFLFVGVAIQSASQNFSMFIAGRFFVGFGNSMASNSAPLLLTELCHPQHRGRVTTVYNQLWDIGSIAATWITFGTFTIKDNWSWRIPSILQAFPTLILFCFIWIIPESPRWLISKDRHAEALTTLAKYHSNGDETDLTVQFEYREIRETLRLEFESKKSSSFLDFLRTKGNRYRLLLVIALGLFSQWSGNGLTSYYFALVMKSIGVTDHNEQFEINGSKTIVSLIVGLIAAAVVDKFGRRPLFLTATFGMFVSFVLWTACSALYDLEGNLAAGKTVIFFIFLHGVFYNIAWSGLLVGYTVEIMPYKLRAKGLMLMNFFVQAALVFNQYINPIGLSHLQPRWRFYSIYCGWLLFEVLFVVVFFIETRGVTLEEVAKIFDGEDAEVAHVDIDAVHEKMQHHHVEVTEVETVSVPKKEHHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7J9</accession>
    <name>A0A1C1C7J9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7J9"/>
    <dbReference type="STRING" id="86049.A0A1C1C7J9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05345"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07196"/>
    <dbReference type="eggNOG" id="KOG0928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="650"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1488"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1594"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1640"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1494"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1508"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1594"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1643"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1676"/>
            <end position="1689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1689" mass="186786" checksum="90764A5171B31290" modified="2016-11-02" version="1">MGEGPSSDVPRPSVTIPASILSQTQIMTPFPADVPFEPAMTIAIDPIALITQECITITSAMRKHARWAQSSVSAILGGGATRVQEKELLRSSSQPRRTSKGPVMLDPGMARLNVPGAGDDDNSSLASRWGLRGRKGKSMQDNPLLTAFARLRRDLAGCRDVSAVDAPELLHPFLQVIRSSSTSAAITSLAVISITKFFAYNIVTIRSPRISQAMHLLSAAITHCRFEASDTAADEVVLLRILRLMESIISRPEGQLLGDESICEMMSTGLSMCCQARLSEVLRRSAEMAMVTMCQVVFGRLKSLKVEEIPKSRSRSNTRTTLASPTDELKIEPPMTGSVMGNGQPERPSVDVDGRVSADGAAEPKTSSSEPQNTNAPATEDEFENVVPYALPSIKELFRVLIDLLDPHDKTHTDAMRIMALRIIDVALEVAGPWIAKQPVLAALVQDDLCRHLFQLVRSDNMVLLNSSLRVAGTLLATCRKILKLQQELFLSYLVACLHPRVDIPQEAGIDPSLYEGVPQAPKLVRPAPSQPSSGRSTPVPIKDRQKLGLEGGARRPEAREAMVESIGTLVRMPSFMVELFLNYDCEVDRQDLCEDMVGLLSRNAFPDSATWSTTNVPPLCLDSLLSFVQFIAERLDQEVPSWAEERIRQLRLQRVRKKIIKSGASKFNDDPKAGVAYLVKNGIITNPDDPVQVAQFMKGTSHLSKKVLGEFLTKRSNEALLTAFIDQFDFVDKRIDEALREVLGSFRLPGEAALIERIVITFTEKYIEATAPEDIADKDAAFVLAYAIIMLNTDLYNPNVAKTQKRMSHEDFARNLRGVNAGKDFPPQFLQDIYEAIKQNEIILPDEHENKHAFEYAWKELLLKTHDAGSLELCDTNAFDAEMFQATWKPIVATLCYVFMSASDDAVFSRVVVGFDQCAQIAGKYGLTEAFDRIVYSVSQISGLATEVPPSTSLNTEVQVGKKKIMVSEMAVRLGRDFKAQLSTVLLFRILQGHENAVGDTWIYIVRILRNLFVNSLITLPTFEQSRLGDIGPIPLQPPSQVIDRDGRLSESGIFSTFTSYLSSYAADDPPEPSEEELENTLSSVDCVKACRPDRVLQHMFSLPPTQIKYLVSALLSQLEESSPVVTVKPERPIPVTVRVNGHRMPKAGPEYDPGTVFLLELATLLTLRDEQTIAAAGEQLTGSLQNAVRDASNLHPLAAARVVHYLLELLRYSYTHDFMRAPVVLHAISSFDDQTLDRTASTITAGLSAAISSATPLRNEITKSPDFWSTLQRLHQHKTEAEKVLDILSHLATQDQALTADNFESAVSLANDFASAGSIGSIQEKRKDFAAKQGRRAKDARPEDAALVTRANQAVSLIYQLTERVPSLIDQSHLERSEAWAAYWSPIFRALCSQCVNPCREVRYRAISALQRTLLSESVADTGHEHAEWTAIFDEVLFPLTLRLLKPEVYQLDSVGMNETRAQMGGLLCKVFLRYLDRLHDIPLTTETSMTAEEEEDEEDEEGEDHAEKETNENQMQDVKDDALARHQVEDKGTGTRMADIYLKTLSLLDRLMNAGTIDPKSSQTDALSEAVREGVKNTLLVMDGAGYLQRTNTSGALSQSPTSPRTDITPQRGVVTDAEIWPETIRRLERFLPGLVGELFPREAEEKEAQEEGKKTKEKEKEKESDAGTGAGDENKKPGSRPQKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7L6</accession>
    <name>A0A1C1C7L6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HDA1</name>
        <name evidence="13" type="ORF">CLCR_05709</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7L6"/>
    <dbReference type="STRING" id="86049.A0A1C1C7L6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05709"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07132"/>
    <dbReference type="eggNOG" id="KOG1343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070823">
        <property type="term" value="C:HDA1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990342">
        <property type="term" value="C:heterochromatin island"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140720">
        <property type="term" value="C:subtelomeric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031078">
        <property type="term" value="F:histone H3K14 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902794">
        <property type="term" value="P:siRNA-independent facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="12">
        <location>
            <begin position="117"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT44449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="491" mass="53626" checksum="7886476F8F9B2AFE" modified="2016-11-02" version="1">MAPKPPSPPGVLPQAANGPRFANPIPQLPEQALLSEDISMRETPDMSGDINSRLRIESPSDDTSEDSLMSDSDSEPDETLPKSQRGLPISRLPTGLCYDDRMRYHAEVAATSAENVHPEDPRRIYYIFKELCEAGLVDDKDYPPMVEQPLKRIDAREATKEEILLIHDEEEHYNFVRSTAAMSNAELIDLSESAEQDSIYFNQLSFFSGKLSAGAAIETCKAVLDRKVKNAIAVIRPPGHHAEPLKPMGFCLFNNVCIASKACQIDATLGQECRKILIVDWDVHHGNGGQRAFYNDPNVLYISIHVHMNGQFYPSGPEGDMYHCGEGPGLGKNVNIPWPSKGMGDGDYMYAFQSVVMPIAVEFDPDFVIVAAGFDAAAGDELGGCFVTPACYAHMTHMLMSLAGGKIAVCLEGGYNFGAISKSALAVTRTLMGEPPDRLQATAATSSAIDTISKVRNVQSKYWRSIYPKEPVAGIFGGERLHGKKLNKAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7N2</accession>
    <name>A0A1C1C7N2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_05621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7N2"/>
    <dbReference type="STRING" id="86049.A0A1C1C7N2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05621"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07169"/>
    <dbReference type="eggNOG" id="ENOG502SU65">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="6">
        <location>
            <begin position="438"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="648" mass="70870" checksum="B492A20F2D16C616" modified="2016-11-02" version="1">MAPRRSTARASSATPVRGATPAKRPTRASSALEPEDAIPRRSTRGASQQPSIANGDVNNPRLPEVQIQQSYTYGSSKAPVLPTQLIARSRMNLLQMAETIDAGVDQAEQHLQHHMEETRANLQKDAREERARRRASRERSQDGSVASDEPEQSRSQRVAAWASSVDDPPQLNGIAEEEQEDEQVEEQEDASPARSTLDDASDKGTDPSSFPSGMFDHSYNYERGLRKPNITIRQPQEPFLGKISRALRERAQRGRHASSQFASSTWSWLQRLLAAVGESIRNLPNSPLISTMTTLLFTLLLIGAASHSFCYMYNNYVCDPLAVSLPGQMLQRYCGTCARTPGRAPLNFTLGGGDDLSKLSVAINSINHQLRDLETRINDKVDSKHAAVDKGIDALKKQHSELSSHVANLKLGGRANTLSGDVASPVIPKINYLAPNNGAMVEPRLTSPTMQRPLAFIQRVLLRVFLSAGYVSKPPITALSPWQDVGDCWCASSAPGADAEHDQADTMRLGVTVTEMIYPTEVVVENYPSGGSLLPGSTPKVIELWADFGHLDSREWKSLSIRQMQSEGGSPIGPTYALVGRMEYDASGEASHVQAFPLDVNQDSLAYAAQNFVVRVTENYGAEYTCLYRVRLHGVPVFEHSSEGALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7V0</accession>
    <name>A0A1C1C7V0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein ESF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">18S rRNA factor 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pre-rRNA-processing protein esf2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">esf2</name>
        <name evidence="10" type="ORF">CLCR_06028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7V0"/>
    <dbReference type="STRING" id="86049.A0A1C1C7V0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06028"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07213"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT44531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="364" mass="41699" checksum="CD2B087771B1AEEB" modified="2016-11-02" version="1">MAVERRNTYLDAGVSDESDRDTGYDSEAAEISKARRTSKRRKIQHEYTDQEDEDDEDDEDEIDSRTERRTNSTLEKHGAVQAHAELKQQREVDENNDSAGEDDNAEPSEQDEEPERKDRQTLTHPQSEPATSSQKEEKKKKKVKDKDKKKPTPGVVYLSSLPPYLKPSALRNLLDQRGFSPIARIFLSPASKSNKSHSAGGKNSRQLYTEGWIEFASKKTAKRCAETLNASTVGGKKGGYYRDDVWNMKYLRGMRWEELMAGVREEKREMEGRRDEERRTIARETKMFVEGVEEGRRREGMKRKREQKKKAPQSGGRAEQEGDGPGDPKRTWRQNEVLGSKRKDQTGGDDKISDDVRQVLGKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7V5</accession>
    <name>A0A1C1C7V5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_06449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7V5"/>
    <dbReference type="STRING" id="86049.A0A1C1C7V5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06449"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07269"/>
    <dbReference type="OrthoDB" id="4525599at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10382" checksum="128ED307C6F2B0D6" modified="2016-11-02" version="1">MAWTLLAAGFCFYIPESSRAHVGMIAFFIYVFTALYSIGQGPVAFVYSAEAFPLSHREIGNSWAVSATFALSSALSLTFPLMLSTFTPTGAFGFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C845</accession>
    <name>A0A1C1C845_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_05348</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C845"/>
    <dbReference type="STRING" id="86049.A0A1C1C845"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05348"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07301"/>
    <dbReference type="eggNOG" id="KOG1240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000497">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="425"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1132"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="859"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="898"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1030"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1421"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1554"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="907"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="947"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1036"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1579"/>
            <end position="1601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT44629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1653" mass="184223" checksum="312CECB9F3AE3D73" modified="2016-11-02" version="1">MGQGYSMTTLSAASAGIDVPELADLVHEKTLASARFMKSVRARSQHGFVFVKAVMKPYSSFRVHEYVRQITEERNILAEIPNALGYQRIVEVPSGGFLVRQYMFSSVYDRMSTRPFLEDIEKKWLAFQLLCAVRDCQARNVYHGDIKTENLLVTSWNWLYLTDFSSSFKPTNLPEDNPADFSFYFDTSGRRTCYIAPERFTSTEMPDEQGELNWAMDIFSVGCVIAEIFLEGPIFSLSQLFKYRAGDYNPEHTHLSKIDDPEVRAMILNMIALDPEKRYSAEQHLSFYRSKIFPDYFYSFLHQYMLDLTRSATALKPVELTLDSLNEFDDKIERVYYDFDKISFFLGYGPSDSKSSSKSALTMRANNKVKTTDADPSLYDGSLLFLTLVVASLRNTAKASARLKACDLLVAFAERLPDEAKLDRILPYIVGLLSDPSDVVRAAAIYAMTSVFEMIEVVSPINAYIFPEYILPRLKSLAAGHSGEPSILVRSAYASCLASLALSAERVLDMVHAIRADGRLPSLREDELPPQQSYQALYDYSRREFLPHFEDSTVALITDPEPSVRRALLGSISRLCVFFGSQQSSDVILTHLNTYLNDKDWILRCSFFEALVGIASYVGATSLEKFILPVMVGSLTDPESFVVEKVFRSLARMAALGLLQKSTTWELVSIAARFSIHPSIWVRESAVQFIVLSAKYIPAADQYCIILPILQPFLKGSISALTEERVLDNLKRPLPKIVFDSAINWAARKATSLFWTAASRDAALTLSDPTTPQNPTALTKRLLTRIPPSQKDKDDQISLESLRNLGMTADDEIKLLALREYILKVSRHKSSEDADQRHRMLNNIIALNQIEVTPQNVFFDSRQPLRESTGGPRRTQQMSRRDERHSLADALLDASTSIDDHMLRRISPTQQSSGTATPSTQPMDIQSQKPSGARASAGPAIAIETASVSSRPSVSSGTPLNGDKLSLRRNTPLELRHRNSGLNLMNRADSAKAEAEISTLPENAFGRVEVDGALHRRSTAGPSALSVTANAAAKSRSVSPRPQSGTRTPLFEPNHSYQGSDANVLRLLDNHFLENFPIDQMDFGGNRPFAETRTPIRRATDVLQQTTSRAAQQEEKFRMEPWRPSGQLLTQFSEHTAAINRVCAAPDHAFFVTASDDGTCKIWDTIRLEKNVTSRSRYSHRRADGVKAKSLCFVEGTHTFLSGADDGSIHAVRVDYRSVEGGETSRYGKPSLVRDYTIPDNYTVDGSHESIREYAVWLYHYRTPSSQSILLSATNKGRILAIDLKNMEIIHSMNNPVHHGTPTTFCLDRKHHWLLLGTNQGILDLWDLRFKLHLRSFGIQTDSRIDRILIHPTKGHGRWVMVSAGGEISVWDVEKMVCREVMWPSTFSPSSGKSRPYEAWSPDEENSERILARFARQVSEDTTLTEPRLHDPGDTADGSPTKKKMPVSTPTAPAVLPILGMYIATDYTASSHADSPNKHAILFTGGADRALRYWDIGRPENSFIVSGPQLHDSEEATATSVSVRAKYKYEVSHPLSLSAGAQITLVQEKLSIAEEAPSNSSRHTPKRRADTPTQTSSGTPNPHAASNATANASSPSTPSTPQAMKPPRNTIISAAQQQLLRTHLDAITDVVMLRKPYGCVVSVDQGGNVYVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C857</accession>
    <name>A0A1C1C857_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C857"/>
    <dbReference type="STRING" id="86049.A0A1C1C857"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06143"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07396"/>
    <dbReference type="OrthoDB" id="2910287at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650646" description="Secreted protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="23565" checksum="3273259705CF3B9A" modified="2016-11-02" version="1">MHISAGNTLSTVVVAVFAFGALGAAQAIPQITAPAMPPMSDNQTWMITPPLTPDDADYVDESDFARLAKRSPPAGSYICDGTNWAGNCKWTAVRDYQCFDYPANAASSFGPPQAWQCKIFYSKGCAPGTGTDGKLTYPGTANLGATYNRIDKPGSYMCRMCNTVPGDHPCVNNNAPDFYFAQVKHGYGGDGNTCTSWDTKIGTTTKYTCLPQATVDPHFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8F9</accession>
    <name>A0A1C1C8F9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8F9"/>
    <dbReference type="STRING" id="86049.A0A1C1C8F9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05475"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07495"/>
    <dbReference type="OrthoDB" id="26149at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="851" mass="93702" checksum="FB6F6E06F5B28CD2" modified="2016-11-02" version="1">MASVEGHEAYCRLADDLEQYWSADEDLNRTHAAIISSLKSASDHPNVGRQQIMALMPPFARHVEEIVQKGRPEEFQSAILGTLADATREVPIWRPLFGLAERPDRAMNLKQMDRDTPPDSVLEVARRIVARTIHVSSSEQIRCALRIIANSCADNNVNRSSFIGRDGIEALLELLRLGKDCDLVIPVLYNVCVDFDEPAMDVRGEPWAPLPQMRAATGETSTASALSMAEQRLGTYWFPHENKTSFQILLEARNQAEDCAGTLADLIEMGSRVALYGTRYFVQEHDGNEPGDIVEVDTTAEIVRLLLSQGADLAEGNIECRVSICQAALNLLSQQDTHTTVINSDNAIRKLIHLPCPPTHVQSALKPDEDDEEEENALSPYQKEILKLTYTISATEAYAETFDIGSHLIQSCILDLGRFLDDQSTPTSPPASAPLASICVLLANCINTTDRAKKLLRDGPDIAVVLQSLFIKISDLKILLPAVDLAARLALCAEGQDVFCNGQVSIFLAIAQILHNRASEVDAIGLEVQRNAVALARLLVKGQSEDVLSKFSIDPGHAPHASDLFTATSLTSEVYSLWDRTTDAQTKIEIGRLFIEILRTIHGPKRHPAVRIAPTVAAHETAHAPTQPPTSSLTDEFNPLDVSSATPMAGIFEDKVAEMITYTLTQPQGQLQSQPQPQPSPLASMQTQQHDNSTQAQAQAQAHAEAEAWFGLALLSTMTSTRPSIRATLARNDFHILKRLRQIVASNASPVEKDDGAKPPNPADQTVGQQRQRQARQVMADPRYENIKVLVVKMLQTQTEQQQQQQQQMPSPSWRQTPTPGPQRHLSREDEFVQEGLEAAATEMGLDWVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8L4</accession>
    <name>A0A1C1C8L4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UV-endonuclease UVE-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_05507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8L4"/>
    <dbReference type="STRING" id="86049.A0A1C1C8L4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05507"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07466"/>
    <dbReference type="eggNOG" id="ENOG502QTMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="433"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="500"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="784" mass="86942" checksum="94739FAA5982A9CB" modified="2016-11-02" version="1">MGKRKRTSEADTPATAPSSTRRTTSTRASAVAPAKIDTNPDTNTKIRDGADALRASPDAEEPGDEKVKKAASGQAKSKAKNKTELGDAEQVAEGLSMSSAGLKNHAQRDDSLHRGDPEADDEEEADPEELKEALSRPPPVNSSYLPLPWKGRLGYACLNTYLRAANPPVFSSRTCRIASILEHRHPLKDPTQPEHATKNRPDKDQTPDIARGQAYVEALGLANARDIPKMLRWNDRYGIKFMRLSSEMFPFASHDVYGYGLASFASDALAEAGRVAAELGHRLTTHPGQFTQLGSPRKEVITASLRDLEYHCELLDLLKLPPQQNRDAVMILHMGGAFGDKEATIARFKQNYVKLSQGIKDRLVLENDDVIYSVHDLLPVCEELNIPLVLDFHHHNIVFDADKIREGTHDIVSLYDRIKATWTRKNITQKMHYSEPTPSAITARQRRKHNPRPATLPPCAPDMDLMIEAKDKEQAVFELMRTFKLPSFDTFNDIIPHVRHDENKPWKAPKPKKNPKKNNKRRSKSRPDDEDGGEGEDHDEEQVEHTPQPLPLIPDAEVSMGGPDRRVYWPPGMEEWLRPKKREVKPRDPEKAKTTAERAALRRAEKAAWQAAREASADAGTDRAVTGTGTASETDGTPATATPARDKLDLEKTRSVYEVAKTSGKSRQPARAPAKNVTSNQKTEQGKKKKNNAKPVLTPSDSGSDLTDLEADIDMATEPSEHDDPGDVMPDLTDAEEKDVAVLPPQPPKVKKTPSRTRTTSARNAKRKAVNYAEGDEGAEEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8M5</accession>
    <name>A0A1C1C8M5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative G2/mitotic-specific cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_05547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8M5"/>
    <dbReference type="STRING" id="86049.A0A1C1C8M5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05547"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07532"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="428"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="521"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="525"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="656" mass="73270" checksum="C7F2D9A65152F8FA" modified="2016-11-02" version="1">MDVKPQRPPRPLRVRNDENMPPEGHPTKTIHQRNKSSPALVTTFAESQGLKAAAKRTAFGDVSNIAAGRPSKDDSTLQTKGNIKPNQSLEQRRSLALLRPAQKGLKNILAGASAVTASKTSTNPSTTDGVSLQPPKKTLTKRHTAIFKDTRLGVVQGTELPSSEAVNALPEKEPVLELAQSSTEPQTCLLPPPAPAPVATEPTKEIQNLHSDTSLPGIEEVSLGPPVPSNANNEIEFKGVSATASEYLPQQPSEHSYDRLVPHHLQVSTETHAPAVRKEAQPMAVATLVNPVENIPPLSPHHSYIQRKIEQEEYWDEEDDDNYEEEGYVTARSFRSKGDNTTGGATTVLFPQMNQRARKEIAAAKQLVEATRSPEEVEDESYDTSMVAEYGEEIFDYMKHLEIKMLPNAHYMDNQHEIQWSMRSVLMDWLVQVHLRFNLLPETLFLTVNYIDRFLSCKVVSLGKLQLVGATAIFIAAKYEEINCPSVQEIVYMVDGGYSMDEILKAERFMLTMLQFELGWPGPMSFLRRISKADDYDLETRTLAKYFLEVTLMDERFIGSPPSFTAAASHCLARAMLRKGSWLKPLVGLLLECCEDPRKHHSAVFNKYCDKRYKRASAFVETEIQRGFQLPDPAAALPLLQPSMVSFYDSVPYLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C923</accession>
    <name>A0A1C1C923_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TRX1</name>
        <name evidence="4" type="ORF">CLCR_06410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C923"/>
    <dbReference type="STRING" id="86049.A0A1C1C923"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06410"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07660"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="23"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="141" mass="15847" checksum="06C0B2BD5CEA435F" modified="2016-11-02" version="1">MVVHNLAEYVAYHQAKFREEHARNNPQPAKKYGVNPIRSKSSYTSSVVQGPADKLIVLDCFATWCGPCKVIAPEVLKFSNSEQYKDKVDFYKVDVDEVPDVAQELGVRAMPTFMFFKNGEKVDEVVGANVRALEAAIQKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C931</accession>
    <name>A0A1C1C931_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromatin-remodeling complex subunit ies6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_06325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C931"/>
    <dbReference type="STRING" id="86049.A0A1C1C931"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06325"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07716"/>
    <dbReference type="eggNOG" id="KOG4137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="6">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT45044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="203" mass="21822" checksum="DF2B2DA2815A4F68" modified="2016-11-02" version="1">MPSTPAPQDDSHQQLLDQMDIFYTPKPFRNPNWKPGTRRNKNTKQIISESQRKEASVLATQNNSGASTPLPATGANSDGAATPVHSSAGSRPVNMAQATQSLSTLVLERNLQRDKASSGAFTGPAGGLTAGPAVTYTNIESAPSLHPANQKRYCDITGLPSRYTDPKTKLRYYDKEIFAVVRSLPQGAPDQYLAARGANVVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9P0</accession>
    <name>A0A1C1C9P0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9P0"/>
    <dbReference type="STRING" id="86049.A0A1C1C9P0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05485"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07863"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10023"/>
    <dbReference type="OrthoDB" id="412402at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="578" mass="64608" checksum="3E406B38C8E00711" modified="2016-11-02" version="1">MPSPLKLTFGVEIEHLFGIKQNEVAVKPEYAWLRPENCAVETDGVGMSLPGWYPESYDPMDKQHRTELYLAGLRQAAKIIRTNAGQDAPMVELDADGLDSNGLQELHDQLRAIPKHCNPEAPYFFATGPEIGSVHVHVGVQPGAEREQEGLSTEFLQHLAFICMVFEDTITLLHHPERQGYQGTKAFKYAKSNRTAINASGHSCALAPEFSCEEAFLKIFEVDVDERDLLHTLLNKTSRQPGGKRERIVNFTNALGEDQGQYLTRTVEFRQHHGTLCTEDICEWVIFVTALARAAERKEHEQTAPGATLPESIREKIQALNDGVRPYVEDQANKYIWLFQEGAKKKNLEDLFDLLQLPAQRREYWWSRARTMKDLANTEKYKGRSTCEYPCACDPPCGCVPLCDSNLHCKCKFPCNGKPLCSLPPRRDCAEWHTDEWIIPSYNDGRRIGKGGNAYAVADDAETETEAGTGPVALIGTEHEFETEPDDVMLVPSEEVTSATMALSTNTIVGMKRSLEAAGEDEGEVCLSRGDKLKHEVSSVKAGERDCEFDDQPHSGRWNAKSKHGARPSDMPPYTGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9Q6</accession>
    <name>A0A1C1C9Q6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BOD1/SHG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9Q6"/>
    <dbReference type="STRING" id="86049.A0A1C1C9Q6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05552"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07856"/>
    <dbReference type="eggNOG" id="ENOG502S313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5579731at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28034:SF1">
        <property type="entry name" value="NUCLEOMORPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28034">
        <property type="entry name" value="SET1 COMPLEX COMPONENT SHG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="2">
        <location>
            <begin position="42"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="724" mass="87865" checksum="00B43698CD4F3432" modified="2016-11-02" version="1">MADAMMTDAPAIDSDSPFSLRPRFKISDLPLVKEQRSTIDALLLKFKKQGGYDSLRKQVWASYNTSDAKTALTDQIHTIAEQEIEKDPKLLSRERGKAATLIQGAVERSGIYTDVESRIDVEIAKHLSTVLDAVRDIRRADVGVEVAAEEEQRGGKSDEQYSQETQNRAAERERNRSRMEQLLRETAELKAKIKAQEEKKRKEEEAKREEEERKRREAEAEERRLAREKRRKEEEEKEAERIKARDERHRKREEERRERHARYERERDRERDRDRDRDRNRDRGRDRDRERDRSRDHDRERERRRSTDRRGSVAESATLTTTKDVAQTDEKDLEATALELLLSEGKKMAEKAKERPAYDFEKSELHDSSRKYASTSDRYARRTRDKSRDSHRRRSRSREPRSSAQEKEKDGSRDRRSSVIQEKEKDRSRDRRSSVIQEKEKGKSDTPRARSPSKDREEGEARSRQNSPSPTQEKRTTRETRERRPRSASPLGIDRYVPGGGTHRTEEERERDRQRRHLRDSEKDSHRKYDSHRSDRDVGERDKDRDRDKDRVDADRDRDRDRVRDRGTRDRESRRDRSRERDRSRDRDRDRYRERERDRGDRDRDRERSRDRDRERKRSPSRDRDRDRDRDRDRDRDRDRRDRSRRRDDRRDDRRDDRRDDRKDDRRDDRRADRKDDRHDDRRDDRKDDRRDDRRDDRRRERDRGGDAGRDRDSVKIDRYVPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9R2</accession>
    <name>A0A1C1C9R2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bactericidal permeability-increasing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_05444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9R2"/>
    <dbReference type="STRING" id="86049.A0A1C1C9R2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05444"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07924"/>
    <dbReference type="eggNOG" id="ENOG502QYDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19394at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027842">
        <property type="entry name" value="HAM1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14613">
        <property type="entry name" value="HAM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like C-terminal" evidence="2">
        <location>
            <begin position="631"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="826"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="878" mass="98010" checksum="AD554C2CA4540ADF" modified="2016-11-02" version="1">MATVNRPTDNATKEKDINQKLQLYGIFQAFSNGKVPSNKQIDVALNSALSSKFLSSPSSKLSSEGRELVADLRQVIRQAQHLLLSKNEGNLLQEFIWDTQNLDGSNASLPNAPTDKDTARQHGDQALDGLKTLGRLILSNGQFRKLLSDAVVLMRDVAGDAAQNVAGKVNPPEDRLNQIDDPAEDNTWHDVPDLSRENIRNQARDTFNKNSPLSRDDVREAANQGADTAQQHPSQDNREAGVSGLQNAADHLQSRADQNIPDERKEDAKKAKNATAQRTKNYANKKFPQERRDQTIWRLKKMVVEIQGHSDYRQAIDTLLSLAEEYGGHANNVTSQTAGTVKGAHGDNPAIRDNKHALTKFKTLIERFANYTSTDDFFDALNTIYRDADRDPELKDWFKAVDRYIRKCLQEQGYILQDEATDEYNRLHDHGRFLLRDRYRDHTDRILDEVKFLADQFDQDPQNKAFGDAVQKLFLDLGNDENGKATFKPHLIKDITEVIIPEIFENTRYIPIPRIEVSDPMIDAVVENLVIESDNLFPNVLEFGSDNYFRMGRKGVSNKRDNKVTIAGSGVQMDLRDVAYYIKRKQGFPSITDKGVMDIFLGGEGFSFKISARNATASDRTHFVAVDKVDVTIKNLSVKIKQSNHKLLFTIAKPLLLKVMKPAIQKVLEKQIKDTFIKADAFAYSVHQDVERGKQATKDDPENAPNVWQSYFNSYQKKMTEKKEKAKEKASKTNVNVAVTKEDSMFKHINLPGGVSTKATEYKDLARKGDRWESPIFSIGSAKESSDLPKPGKITRKPHDTAEGRIRGGNHPNTRDDMSAVSGTTAASNPMSAANPSHATAGFSNQVDQAFGSSGGTNGSANLNKPNPSGTYYDGVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA97</accession>
    <name>A0A1C1CA97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA97"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06019"/>
    <dbReference type="OrthoDB" id="4766028at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="332" mass="35184" checksum="373144BD76C3EF7D" modified="2016-11-02" version="1">MWEHGLAEKAKAVEKNILQRGMAEGAVIQSTGAVDDLTTVQFYSSDDCSLGSEISRADAGCLTVDNGAIGAYNSFQVISSNPLAPRAPTRRSPEQRRRHFRNTTVQEPQPSTPLLYHGMTATFDGIEYKWQQIHASGYIGVLPHRWDDALHTRNTTEMAFQNNIDSGANYLEERNLYEAACSTYMKCYSAVRVAGENSVATIGQFAGPYFASAGQAALSAGVSVNEFLNNNPFIAQLTAGGAAGLVSAWVGAQLQGDSKNCQACSTQNEQIDALISIIQSQNSALNAASATVTAQVDNAGDDVFSLTMTVVACGQALTATGCGIPAGFCTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAJ2</accession>
    <name>A0A1C1CAJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01520"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03400"/>
    <dbReference type="OrthoDB" id="4148461at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper-fist" evidence="2">
        <location>
            <begin position="43"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="544" mass="59180" checksum="BA64F733245A6C94" modified="2016-11-02" version="1">MSDTSVTTPRVATPPKGASRVEDGKVRKLKASYKSETPAVQHINGKTYACESCKRGHRVHKCDHGKTRPISETNQPGRPSAGTKRGCQCPRNCACTTKTCKCERDCACTQEMFLIVRLDNPTVVSRESTSTPKPVWEDSDGTRLTLKKVWADANGKEIDDDEYEARKRRMKEREDAAKDAPRSSCCSGKTPKEEPDSPKGGCRHRQNVAAIQPHPGPSIRDSGLPLHAPTPASEPWMSSCSCGSGCSCLYCPDHPNNATSINHAQQQVKNLAEQAYIGGHALTPVPSNSENTSRSCMGGQPSFFLSSTPDVSQHQLQQFFSDTLNPNAIYLAYPIQQHSWTNRPLSSHCSRVHSPSEVMTISPDAPDMFPDPLSDMPIPLHAPNDVSGTWDFSGNQLGRSSFSWTGLDASYGTDYNIGQATVASISNSAPPRMLPAPNAIETPAIGGNLNTVTNHSLPIHFTDTLPQLDENAFVDFDGPISPNQPNGNTSMVNHFSHETLPTFNVQPIQGGCCSTPFVDLDYSQDSEFNMNAISRTNSPIVNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBC9</accession>
    <name>A0A1C1CBC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL30m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MRPL33</name>
        <name evidence="9" type="ORF">CLCR_01770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBC9"/>
    <dbReference type="STRING" id="86049.A0A1C1CBC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01770"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03705"/>
    <dbReference type="eggNOG" id="ENOG502S7S3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="509901at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000010">
        <property type="entry name" value="Large subunit ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="8">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT45815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="88" mass="9721" checksum="E5A3CE34E6BBC7F1" modified="2016-11-02" version="1">MSYFRITLIRSAIGLPARTGNVLKALGLRKRMATVFHPVTPSVAGQIMKVKELVAVSEVDKPLTKQEVHQERVPDAGFYIESKASEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCM2</accession>
    <name>A0A1C1CCM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LRP16 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCM2"/>
    <dbReference type="STRING" id="86049.A0A1C1CCM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01245"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09290"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001664">
        <property type="entry name" value="PRK00431.1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="29"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="368" mass="39315" checksum="EC07D6F1F5784CE5" modified="2016-11-02" version="1">MSSAVKSVAEIPTVSQLFRRGELKPSTEEDLPTPNQQLNNKVCTYKGDITTLECDAIVNAANRRLLGGGGVDGAIHRAAGPGLLRECRTVNGCETGSAKITDAYNLPCKKVIHAVGPVYKSIEESEPHLRSAYRTSLKLAVENDCKTIAFPAISTGVYGYPSKAAARAASREVYRFLTKPEGQKLDRVVFCNFLDKDVTAYAECLPYVPLQAPVRSSTRCTDFSGIRLVFAPTEDDLSHTGECTSVANGSPKEMIPTNSQTRPKEAYDPGHASRCGVMVGQTATTPSTNQTGKHSPGGAVVRQSILANAATSPDSDVRPSAKTSRDACSGNSTIDGDDRVRESTEKGIDSLADVVEHTRTTSTTRTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCN9</accession>
    <name>A0A1C1CCN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CwfJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_01142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCN9"/>
    <dbReference type="STRING" id="86049.A0A1C1CCN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01142"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09285"/>
    <dbReference type="eggNOG" id="KOG2476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="3">
        <location>
            <begin position="302"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="2">
        <location>
            <begin position="457"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="562" mass="62454" checksum="D9BA376444D0AD06" modified="2016-11-02" version="1">MGTAKILVVGSVQGEFKKAFEKISKLQAKQNFSLAIIVGDVFGSDNNENSSNELDALLTGQITVPLPTYFTMGDNPFPQNVKAKLESGTDLCPNLYYLGRKGIMTTTEGVRLVSLGGRLMQNEASSTEKPGDCDPSYLDTEARGLHGAHSAHILITNEWPANIRNGSKIDLPEGVNDSRGTQSISNLCQALKPWYHFSSSPAGLWEREPFKHVADYNSLEEPSVTRFKSLPSVAAATKEWMTAFTLDTSRPPATVEPPAESPFVRSSPPRKRPALDDQAAYRRYADNGYEPRHNKRARKGPRSDPSDCFMCLNKPGSKTHLVVSLGEESMVTVSRGPLPLPTTFPQLSFTGHVMIIPYYHAADEMAHGKRTLQEVATEFKEMSKFRKALSAMVGSKSHGELGTVCWEVNRTGIRHLHWQVIACPADRIKKSMVEAAFKVKAEQYKYPTFQPCDADSQLPERSDYFRVWTWMANPLALADHTNGNADAEGDLGVAQSMYFPLPTDQKFNIWFGREVMAGLLQLENRVNWMDALLRKDGSEQAAEEEEAAGLRADFEDFDFAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCQ1</accession>
    <name>A0A1C1CCQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_01359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01359"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="84" mass="10343" checksum="B0E0FB6F9364346E" modified="2016-11-02" version="1">MSQSMFDRLDWCFYVYSQQTYHHSKLRITVYQTRERRNRPRYQTSQKYKKRAKQLLNYPDFCIAHPSIKFSSHPRFLGTEPYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDC7</accession>
    <name>A0A1C1CDC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_01843</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDC7"/>
    <dbReference type="STRING" id="86049.A0A1C1CDC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01843"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01211"/>
    <dbReference type="eggNOG" id="KOG1304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990818">
        <property type="term" value="P:L-arginine transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089708">
        <property type="term" value="P:L-histidine transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089707">
        <property type="term" value="P:L-lysine transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000067">
        <property type="entry name" value="Transmembrane domain transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="570"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="614"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="660"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="354"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT46481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="754" mass="82096" checksum="772C40C4B87E018F" modified="2016-11-02" version="1">MSSVRSTSRSVEVDSRSPAGAGSSHSRHASIARLSSPVPSGRLNTPPVQQVPTPQQIATDYDNANLPKLDQSGSLPGPGPSALSSALADARNHSPPQAQTPSPTPTPRQPLLNTAAGLGGHDRLPRSNYGSFSAREMAGSPAPTEDPEVVKRHLVQPEQGSTRYGRSLRLDLTDGSGLDPDEFSSLRLQGGDVTRAVYRWAEEQESNQPGKAQRSKSFNIARPDPESETTDIQNIRVPGGFRRHFLRRAAESPARAGETANGNAATGRNAHIPSIGNAPPRLFTNNFLEFLTLYGHFAGEDLEEDDEVLEPDEYFSSDAYDDEGSDREAMEDSALLTPGGLRRRKHKERAPTGTGSSFNAALLLLKSFVGTGVLFLPRAFLNGGMLFSSLVLLGVAILSYYCFILLISTRGRVEASFGDMGGILYGKWMRAAILFSIVLSQVGFVAAYTVFTSENLQAFVLAVSKCKSFIDIKFMVLMQLVIFLPLSLIRDIGKLGFTALVADAFILVGLIYLYYYDIATIVDNKGISDITLFNPSTWTLFIGTAIFTFEGVGLIIPIQESMRKPQNFPGVLATVMVIITLLFTSMGALSYAAYGSKTKTVVLLNLPQDNKMVNAVQFLYSLAILLSTPLQLFPAIRIMENELFSRSGKYNPWIKWQKNVFRFFLCFVCALIAWGGAGDLDKFVALVGSFACIPLVYIYPPMLHLKAVSKTRWQRGLDYAMCIFGVASCAYTTVLTVQQWAGGSGAKEPGYCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDJ3</accession>
    <name>A0A1C1CDJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02138"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01245"/>
    <dbReference type="OrthoDB" id="5819478at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="168" mass="18829" checksum="A673D723CD23C96F" modified="2016-11-02" version="1">MSLLRWLLRCTPGLSVFCLLILLEAALRIVETEWRSFFYPPFLNHIASPVVAQTLFISYAVFLHIVAFLFPLRLCASAYAATRDIKAVHGLSKPTTANTATLDALGNDPDLQQSALKKSDSVTLAVVLPSYKEEVEILESSLRVLASHTLARSSYDARRTLRTIRWHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDQ7</accession>
    <name>A0A1C1CDQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDQ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CDQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01868"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01327"/>
    <dbReference type="OrthoDB" id="5376804at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="628" mass="68534" checksum="0CB76E004C0DA815" modified="2016-11-02" version="1">MSTYTSDGFHASKQEGHVQIRDADGQRRGAPEAGDETPFQTLKNRVLDAIEKYWLFEFFGWTLALGCFIGAVSLLAVHSGRESPNWTLTVGAGRYHKTFGLTVNTVISIFATAFSSGILIPVAASINQLKWVWFQRGRRPLAHFQKFESAARGPLGSIMLLWTLRCRRLACIGAVIVLAALGVGFSFQALVVYPLRAVAVGTSAIQRTNNEWQPISVTTEVPGSVIGAVYSGIFQYSSVFSNRRIVDAPQMKVSCSTGNCTWHETYTSMSLCTQCHEISASIRSTCGTAHVPWNEYYGKAANSTTTTMPVQYCNYTLPNGLEVSGLPSTNFTQFATSSNVANSPHFHADTTVSVLSVVTTVWRASNPTPEYGTSIPMTHGIFSKAAMECGIYYCVQKFNTAVSNGTLDERVIDTYATGRYSTVDNAYVLEPPSSFTNVSTRDDPSANVYSTPNFLSIKQFFSTFWQGNCSVTEAGSANPQSPCTSQMALLLIRESFGTYPAILSRLAKAMSYAMRLQSTPETQPAALGVAYQHKPHVKVRWAWLALPASLLGLALVLLVATIVITAREKTLLWKGSSLAAFSHPLTSDARAAVSEATSPRDVVRVAEKIEVKWEPTDSGFRLVRSHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDU8</accession>
    <name>A0A1C1CDU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DUF6 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_01916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDU8"/>
    <dbReference type="STRING" id="86049.A0A1C1CDU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01916"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01376"/>
    <dbReference type="eggNOG" id="KOG2765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="4">
        <location>
            <begin position="260"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="559" mass="61823" checksum="BE9969E8B58CF0A9" modified="2016-11-02" version="1">MPPSPSDRSSDSSGGDLIYTPAGTESPLPHHPFSRASVRPASPLRLTSLPQPIKEEFRADRQYGKEVHFESDAEPQEDGEDDDDDDNEADDPHMAGRTSMHRPTGPESHEPLLGEDKQSLRGRPASPHEAGSARLPLSRRSTFRSRSPSYTHSEDMVRRKYVYASFFLVLSLVSFVVQTETAVYIQHELGWNKAYCMMYLTHGSWIFLWPIQLVFLRIQKRKLSWPAFWRRHVYLVRSTAQMVRAQELHQHLSKSQAMTSPWPYMIKTTAFITTFLTMAGGSWYVAVNLTSPSDLTAIYNCSAFFAYVFSIMLLNDKLRFDKALSVGLAIIGVLVVAYGDKDDSTPVPGKSNPGAEKGFGTKLIGNIVIGIGSVAYGFYEVLYKRFACPPEGTSPGRGMVFANSFGSMVGLFTLTVLWIPLPILHWTGLEKFELPTGQAAWLLSISTLSNAIFSGSFLVLMSLTSPVLSSVAALLTIFLVGITDWIVTGKPLSAAALSGCGLIIVAFVMLSWATYREMKTEEAKREGEEDKIFDDDDEDEMPDEGAAGVLGASARRRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE04</accession>
    <name>A0A1C1CE04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_01888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE04"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01888"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01475"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT46760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="517" mass="57407" checksum="2AC3B5F6B20AA52C" modified="2016-11-02" version="1">MADIEKNQAHITEPALEVTSPAAKTSFLDRFGGRTNDPNVLGKELLEKALEFDEAQLERDAIKVRRKLDFIVIPMMMTTYMLSFLDKQTLNYSNAYGLQEDTNMKGDDYTWVASALYFGTLVSAYAWNVALQRYPIGRMVGGMVFVWAGVCMLQAAVFNFSGFFAVRFFLGVVEGCIAPAFVLLTSMLWTREEQALRTSFWLSTNGVSSILGSLLAYGSGHATHLAIDNWKLIYLIVGCMTFLWGFVVLLYLPDGPHNAKILTEHERMVAVWRVSKNQMGIKHYTLIPAQIKEAAIDPKTWLVLLMGACTGILNGAVANFTSAIIKGFGFDALKTTLLQTPGGAFELIGCMFFGWVATKPNLLGATIIVSCLPGFAGLIGLLTISIKHRYALVACAWLQNVLGSPIILGWTVPGLNVAGHTKRTTVLGLLFVFYNAGNICGPHLFLPSEAPRYFTAIRALLATYCALIGLQVIYSIWCYFDNKARDRKGYHAQRTEELLEGFEDLTDKQNLHFRYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEH3</accession>
    <name>A0A1C1CEH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear movement protein nudC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nudC</name>
        <name evidence="7" type="ORF">CLCR_02058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for nuclear movement. May interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEH3"/>
    <dbReference type="STRING" id="86049.A0A1C1CEH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02058"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01566"/>
    <dbReference type="eggNOG" id="KOG2265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT46856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="194" mass="21753" checksum="41E7902759A99A44" modified="2016-11-02" version="1">MADRAPSPTPSERARKDAEDRKREEAEQATLPYKWTQTLEEAEVSVPIPGNLKARDLVVDLKKNHIKVGVRGQDAIIDGDFPHPIQVDDSTWVLSTKSDGGKEILITLAKARGSNWWAHIVTSAPKIDTTKIVPENSKLSELDGETRGMVEKMMYDQNQKAMGKPTSDDQKKDDILKKFMKEHPEMDFSKAKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEL5</accession>
    <name>A0A1C1CEL5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CAX2</name>
        <name evidence="13" type="ORF">CLCR_02380</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEL5"/>
    <dbReference type="STRING" id="86049.A0A1C1CEL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02380"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02496"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000026">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF14">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="113"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="326"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT46922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="507" mass="54456" checksum="6DEA2C241AAFB379" modified="2016-11-02" version="1">MGLFNRRAKVAAAESDTTNTTVAEKPNGTTAPAAKDSSSAPSNDGLLPQYNHNGHEVTKGIHPDGESGRRGVHPIEMLKIIWKSSCTASSWVNILWPFVPAAIALHFVKGDHHLWTFAINYIAMVPSANLLGFAGQELARKMPKVAGILVETTLGSVVEIVLFMVLIAKDDGTGEIGHGNKIVVIQAAILGSILTNLLLCLGCCFLLGGLVHKEQKFHSVISEAGSGLILVAGFALMIPSAFFSSLRGSTVPEGQEGYTDVQLRSDTLNISHGVSVILIVAFLLYLAYNALSHDNIFQEVLEADEEADIDRHRDLKKAKLTLTECVVAIVLALALISLIAVFLVEEIEYVVENGVPDNFLGLILVPLVEKAAEHMTAIDEAYDNQINFALYHCLGPSIQTALFNAPLVVIVGWGLGKPMDLNFEIFMVVLLVLSILVVGNFLRDGSSNYLEGGLLVIVYIIIALTAWYYPNAELTTSNGRSGGTESDGGEGSGTEALVHVAKMLMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEN5</accession>
    <name>A0A1C1CEN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribosomal protein S6 kinase beta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Rps6kb1</name>
        <name evidence="10" type="ORF">CLCR_02342</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEN5"/>
    <dbReference type="STRING" id="86049.A0A1C1CEN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02342"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02447"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004711">
        <property type="term" value="F:ribosomal protein S6 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000222">
        <property type="entry name" value="Serine/threonine-protein kinase psk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="258"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="532"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT46973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="616" mass="67679" checksum="792D3FC1DE1D8DBD" modified="2016-11-02" version="1">MDKVSDTSGEMRTAGPTSTSLQEAITAIAVEHNAPSEATEPEIIPFRAKSPPTTPRKTMPVNGQANEAVAEFPTERGRQEVKGSAILSTTAAKRRKKKNKTKAAQPVQALNTVRGFTPADSGAEDSDFSRANSPRVLSPIPRLPALAGASPGLRPQSPGISSLKAQLDALNSRSQSRSTSRVRDTLTSEANSSAASAASDNQEEEPQEDMVSYNVQIDQDFVSQSLAETGTSTATLSSLDADQRATSMIARKMTAADFTPIRCLGDGAFGTVLLVRQNATGRLFAQKQLTKAFLKVHKKRIESTMSERTILELVNRHPFIVNLYYAFQDHEKLYLILEYASGGELFRHLELEKFFSEEVAAFYIAEIVLALDYLHNTMGVIYRDLKPENCLLNSEGHLLLTDFGLSKVAVQDASTPGGSRCNSLGVGTIEYMAPEIIRGSDESDWGPGYGKACDWWSLGAMACDLMTGKPPFGGGNWTKIQQNILFQKLSLPYFLSPDAKDLLTRLLRKEPKKRLGVGPNDINIIKKHRFFRKIDWKKLEAKELEPPIKPLVTNPELAENFAKEFTDRAVDAIARRHSRTLSKSDPFGGFSYVASNSLLEESMLSELDEAIIDEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFU3</accession>
    <name>A0A1C1CFU3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03654"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01991"/>
    <dbReference type="OrthoDB" id="4146299at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="254" mass="28268" checksum="675C15DE26A47A1A" modified="2016-11-02" version="1">MGRVIVKRQMPTRIDRAQPYRRRYVGRDIPDKWHFWTYAMRRGWQNRPREVPAPDLDFSFHPLRICLDCERPVKVTEYCDGNWEIIKQTCRFHRYAPDSGLTSAKDHPMLPIMFPSPAHTKTHHVGSCIVNNTPIISANNGLAQSVYFLRCTGSYVNSIGQAITVGKSIRRAKVGDMKRVPVVRAGIPAIVPEEAPFEVRYANAVLNAWGMGDNEALKDTVRCRITGGGDSFKCGIGGRGVKAGQVGTTGGVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGA2</accession>
    <name>A0A1C1CGA2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">chl1</name>
        <name evidence="25" type="ORF">CLCR_03309</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGA2"/>
    <dbReference type="STRING" id="86049.A0A1C1CGA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03309"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01841"/>
    <dbReference type="eggNOG" id="KOG1133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045005">
        <property type="term" value="P:DNA-templated DNA replication maintenance of fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001372">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002774">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 25" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="24">
        <location>
            <begin position="28"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OCT47544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="856" mass="95502" checksum="154B730D715E4B1D" modified="2016-11-02" version="1">MDGAQKLVQNNRGITVDTSISGITMEPSQANFCHPYQPYSIQLEFMQSLYRCIEEKQVGIFESPTGTGKSLSLICGALTWLRDHERRALQGSADSSDEADWLAQAERSAQRRELLLAREELEHKLASVREEEARRRQRREDSKGSKKARIVKESVGNSLAEDEFMLNDYDSDGGNTSSLPKSNNGISSATQALLDKLQGPAKKEVEEGKEDRLKIIFCSRTHSQLSQFVNELRRVKPPSSIPSDMAAVPPGSHIEEGVKHLTLGSRKNLCIHPKISRLSSTTAINEQCLELQKPGIAKDKKCPFLGSKDDLDTVNAFRDRVVADIKDIEDMGKLGRDMELCPYYASRSAISMAEVLTLPYPLLLQKSAREALGVSVKDNVVIIDEAHNLMDAIVDTLSTSLRLSQVDQAVQQVTAYAMRFKARLKGKNRVYVMQVIRVLNSMTDCLKAITFKPSSTETTITAAQLMSGKGVDQIKPHKLLQYLHESKLCHKVEGYAESQSSDQDTYSKGVLMQFQNFLAVLMNPDEEGRFFASRHDKDISVRYTLLDPREHFREVVQNARAVILAGGTMSPMSDYSDYLFSYLERNRLSTFSFGHVIPASNLLAQAVVKGPSGVEFDFTFEKRGSEKIMVELGSLILKMCTVVPDGVVAFFPSYDYLAQVLSVWQRLPDEQPIMTALSRIKPIFQESKSSGVEEVLRHYAMAIDTGQGGLMLSVVAGKLSEGINFSDKLGRAVISVGLPFPNANGAEWQAKLQHIRDVRYQQCKKEGKGEADCQSAAKSASRDYYENACMRAVNQSIGRAIRHKNDYAAILLVDRRFATERIGRKLPGWIQESMASGVPSWLEMETGLQQFFRGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGI4</accession>
    <name>A0A1C1CGI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03769"/>
    <dbReference type="OrthoDB" id="10547330at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="101" mass="11115" checksum="826B279C06E3A438" modified="2016-11-02" version="1">MFNLIVPDGAGTKGAFTFGKPVLGALLSTQLGLAMSDRTFLDVQCIFTATAVESDHRRSPLYDVRIECRQRGEVQYGGINRESEDESRQPCGVTFDRGSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGU0</accession>
    <name>A0A1C1CGU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lysine--tRNA ligase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">msk1</name>
        <name evidence="5" type="ORF">CLCR_03560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGU0"/>
    <dbReference type="STRING" id="86049.A0A1C1CGU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03560"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04607"/>
    <dbReference type="eggNOG" id="KOG1885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070154">
        <property type="term" value="P:mitochondrial lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF5">
        <property type="entry name" value="LYSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="4">
        <location>
            <begin position="48"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT47734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="403" mass="44603" checksum="8EA7B394F7A81C09" modified="2016-11-02" version="1">MSLPAIQSPCLQRLPVEQRGSATTAIAESNYQPRHVEMLSDPEIIETLKIRSTLTAAMRRFFETSSFVEVSTPILSAGAGGATAKPFETAATEFSERKLNLRIAPELWLKRLIIGGMDKVFEIGPCFRNEGLDKTHNPEFTTCEFYAVSHDLQQLIDMTEQLLASIRVAVQSVSHSLEERPLFQQLQAGFQVLDFIPSLNSALGRELPNLTSPDAHSSLLSIFKSKDIALPSNPTIPRLVDKLSSIYLEPHSSEAPLWITNIPECLSPLAKSFIHPAAPNAQPVAARAELFIQGKEIVNCYEEENSPFEQRRKFIDQQRYARAPSPNTSDMAGPVEDKEAMKVDEDYLRALEWGLPPTGGWGCGIDRLVMLFAGRERIGDVLSFGNLRAVTRGAELVNQGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH21</accession>
    <name>A0A1C1CH21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH21"/>
    <dbReference type="STRING" id="86049.A0A1C1CH21"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03690"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04548"/>
    <dbReference type="eggNOG" id="ENOG502S8MB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5397701at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="220" mass="23685" checksum="7300D9F06E227524" modified="2016-11-02" version="1">MNAALTTRPLLRAPRHFAHLRAVSTLSNNPHIYVFANPQNPSSHILSLLPTDPPSPSLAVGTTTKLPPTPQSFTENPRLLPILHSVISESASSDPQVQSEAAVMISNSGASFFQTARRQQTGSAGASDQGGHGSGGRGGWVHVADQRRIPDFGRIPDPEDIFGSVEVDGQGQFVDGHGRYQPSGTYRICTNDGILGLTDFMRQKLVERLKLEEAGERNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH23</accession>
    <name>A0A1C1CH23_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">spm1</name>
        <name evidence="9" type="ORF">CLCR_03593</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH23"/>
    <dbReference type="STRING" id="86049.A0A1C1CH23"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03593"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04536"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="327" mass="37690" checksum="A8B95C22967F1D8F" modified="2016-11-02" version="1">MDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSQDPEENAGYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHYLGTPNEETLSRIGSPRAQEYVRNLPYMPKIPFQRLFPQANPDALDLLDRMLAFDPSSRISVEDALEHRYLHIWHDASDEPACPKTFDFAFEVVEDVQEMRKMILDEVMRFRHHVRHQTNPTPSGNMNVPIPENPSQWSRHEDPRPQEADAFAGASDLEHELQAGADILMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH71</accession>
    <name>A0A1C1CH71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">gpmI</name>
        <name evidence="18" type="ORF">CLCR_03461</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH71"/>
    <dbReference type="STRING" id="86049.A0A1C1CH71"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03461"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04494"/>
    <dbReference type="eggNOG" id="KOG4513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1886626at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="16">
        <location>
            <begin position="6"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="17">
        <location>
            <begin position="92"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="163"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT47860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="520" mass="57435" checksum="B7982CDA7C3D13A6" modified="2016-11-02" version="1">MVKVDQKAVLIVIDGWGIPSESSPPEGDAIAAAETPVMDEFAKDGSKTAQGYTELEASSLAVGLPEGLMGNSEVGHLNIGAGRVVWQDVVRIDQTIRKGEMNKVENIRKSFQRAVDGNGRLHLLGLISDGGVHSHIKHLFALLQVAKEMKVPKVFIHFFGDGRDTDPKSAAGYMQELLNKLQELGIGELATVVGRYYVMDRDKRWERVEIGMKGIVLGEGEESSDPVATIKARYEKGENDEFLKPIVVGGDERRIQENDTLFFFNYRSDRVREVTQLLGDYDRSPKPDFPYPPGIHITTMTQYKTDYTFPVAFPPQHMGNVMAEWLAKKGVKQCHVAETEKYAHVTFFFNGGVEKQFENEDRELIPSPKVATYDLEPPMSAQKVADKLSERISDNKYEFLMNNFAPPDMVGHTGVYEAAIKGCAATDAAIGSVYETCKKEGYVLFVTADHGNAEEMLNEEGKPKTSHTTNKVPFVMANAPEGWSLKKQDGVLGDVAPTILAAMGLDQPEEMGGTSLLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH84</accession>
    <name>A0A1C1CH84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">AP2B1</name>
        <name evidence="9" type="ORF">CLCR_03314</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH84"/>
    <dbReference type="STRING" id="86049.A0A1C1CH84"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03314"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04468"/>
    <dbReference type="eggNOG" id="KOG1061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="32"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="642"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="698"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="666"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="746" mass="81675" checksum="F08005E58C5EA813" modified="2016-11-02" version="1">MAMNRVRNAFAPPRKGETFELRAGLVYHARSQYAYERKEAIQKTIMAMTLGKDVSQLFPDVLKNIATADLDQKKLVNYAKSHPDLCILAVNTFVQDSEDPNPLIRALAIRTMGCIRVDKMIDYMEEPLRKTLRDESPYVRKTAAICVAKLFDLNPSMCLENGFLEILQEMIGDPNPMVVANSVQALAEITEAAPETNALQITPNTLKKLLMALNECTEWGRVTILSSLAEYKAHDVKEAEHICERVTPQFQHVNSSVVVAAVKAVFLHMRYLPQETQKSYLKKMAPPLVTLVSSAPEVQYVALRNIDLLLQKQPDILSKEIRVFFCKYNDPPYVKFQKLEIMVRIANESNVDQLLAELKEYALEVDMDFVRRAVKAIGQVAIKIESASERCVNALLDLINTKVNYVVQEVIVVIKDIFRKYPGYEGIIPTLCKCIDELDEPNARGSLIWIVGEYAEKISNAGDILGGFVDGFAEEFSQTQLQILTAVVKLFLKSPQAAQGLVQKVLNAATAESDNPDIRDRAYVYWRLLSNTSDQNAPKNIILSEKPPITTTIQSLPPALLDRLLGELSTLASVYHKPPEQFVGQGRFGADAVQQAAIEEQMQNARENPLAAAAAAAAVQGKTPGPTNNDENLLDIDFDGAAPASATEKPTDGFSGLEGLAGTPQRVASPTVSQATAPNNMDDLLGVFGSGGSSTIPSSSGFGGMSDNDILNGFASMDLSQSQPPPPKQQLASAGSNSASEDLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHE6</accession>
    <name>A0A1C1CHE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pro1</name>
        <name evidence="14" type="ORF">CLCR_03504</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHE6"/>
    <dbReference type="STRING" id="86049.A0A1C1CHE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03504"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04493"/>
    <dbReference type="eggNOG" id="KOG4165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT47861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="476" mass="50522" checksum="06B467CC9FB3DCF1" modified="2016-11-02" version="1">MSLTSSSPLTCAQSASLASHTLSILPLSSRNAALTAIHTALQENKSAILAANATDMTLAHQASANGELSQSVLKRLDLSRPGKYEDMLKGILDVRDLADPIGRVDLRTRLDDGLELERVSCPIGVLLIIFEARPEVIANISALAIKSGNAAILKGGKESSQSFEAIARVISHALAGTEVPSDAIQLVKTRDVIDDLLALDRYIDLVIPRGSNELVRYVKDHTKIPVLGHADGLCSVYLHKDAAQIKDTAVNVVVDSKCDYPAACNATETLLVHESVLTSVLPDVATALLNKGVSLRCDTKSKAALAETLTKSQAALLQDARAEDYDTEFLDLIIAVKTVPGAEPGEPHQSPLANGHGSSEDAHDPSLLAAIAHINAHSSHHTDCIVTASAAAAEKFLSAVDSAGVYWNASTRFADGMRYGFGTEVGISTNKIHSRGPVGLEGLTIYKYKLRGKGQGAGEYGDGEGKRKFMHVKMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIC3</accession>
    <name>A0A1C1CIC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_04108</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIC3"/>
    <dbReference type="STRING" id="86049.A0A1C1CIC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04108"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08407"/>
    <dbReference type="eggNOG" id="ENOG502QTX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT48260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="463" mass="49893" checksum="2EBA6A191650E0CF" modified="2016-11-02" version="1">MLKPLRVLVVGASIAGPTTAYWFARAGAAVTVVERFPALRTAGQAVDIRTAGVTVMRRMKGMEDAARAKSTTLAGVSFVNSAGRSFGTIRPTGNPEQQSLVSEYEIFRGDLAGVLFGLTGGNDASSNRGISQGQAQDDHHGHNRNQAQGDDRDHDQSQKIKYVFGEQVASIQQQENLDGPVTVDFMNGKLPTTEYDLVVACDGATSRTRALGLDCQVRDHVHPVNLWAAYFSLPGDLLEGSKVGHAYTAVGGRFIALGPDPDPAGVTRVTLMSVHPRKDHDAPVPFREAAAKGDEALKRYVAARFAGAGWKTDQVLRLMMDSASDFYASEIVQVKLPDGLSKGRFVLVGDAGYAAGPTGGGTTLALAGGYVLAGEICRHKGDIAAGLRGYEQTMRPIITDLQKIPPLIPAVLAPQTVWGIWVRNNIFRLIARSGIMEFAHRWFGNAFAEGDKYRLPEYESVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIJ6</accession>
    <name>A0A1C1CIJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein saf4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">saf4</name>
        <name evidence="3" type="ORF">CLCR_04207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIJ6"/>
    <dbReference type="STRING" id="86049.A0A1C1CIJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04207"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08398"/>
    <dbReference type="eggNOG" id="KOG2990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="362" mass="40215" checksum="7EA20C7A0CE81DC7" modified="2016-11-02" version="1">MQGFNMGRYVPPDLEGRVSANTASGKGHALGSRARKLKSEGVLTVRFECPFPIWCTTCQPEEIIAQGVRFNAEKKKIGAYFSTPIWEFRFKHTVCGGWVGVRTDPKNAEYVVTEGGRRRDFGTDERGIRVDAFGSTAVTEEQKDRLEKDDGGFGAVEKKVADRTAAETQKARLEELMRVSQRDWGDPYEKSRMVRRGFRVGRRKRQADERTGEALKEKFGLAIDMEMLPEREEDNERVKFLEFGEQSGPNESLSSTKPLFRPNPTAAAATTATASAGGSSSNTASSSGKMKAKVDKKEMLSTALRGNSRIAVDPFLRDDNLWQPRVKRKREDGQPELELEKKPAPVDSGTSMALVGYDSDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIU1</accession>
    <name>A0A1C1CIU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative zinc-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIU1"/>
    <dbReference type="STRING" id="86049.A0A1C1CIU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04178"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08527"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08243">
        <property type="entry name" value="quinone_oxidoreductase_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051603">
        <property type="entry name" value="Zinc-ADH_QOR/CCCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154:SF1">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="12"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="327" mass="34787" checksum="9E63590CEB4AEC82" modified="2016-11-02" version="1">MSMKAVVIHEAGGPDVLQLEQRPIPTPAADEVLIRVKAFGLNRSEMFTRQGHSPNVRFPRVLGIEAAGVVEACPSGQFEPGDKVASAMAGMGRDFDGGYAEYTCPKAAHTQRLTTGLEWAVVGAVPEMLQTAHGSLFKALKLRADDRLLVRGGTTSVGLAAAAIARNHGCFVAATTRSSSPDTAELMRRSGVEQVIVDDGHVADKVVEGGGKKFDKVLELVGTTTLKDSLNCAVEGGIVCMTGIVGNSWSFKEFSPMDVIPHCVGLTVYSGGPAEFMETPLNDLLQQIEAGTMPVQIGKVFKIDQIVEAHDTMEKNLARGKIVVLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ74</accession>
    <name>A0A1C1CJ74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative agmatinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_04139</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ74"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ74"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04139"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08638"/>
    <dbReference type="eggNOG" id="KOG2964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000014">
        <property type="entry name" value="Arginase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650837" evidence="5">
        <location>
            <begin position="24"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT48516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="424" mass="45967" checksum="DFC7C63FA2E1B5D4" modified="2016-11-02" version="1">MALSLQLNLTLLIVLLSLRAITAHSHSDHDTDSSGEEPPLSFSVGPNYPYALEDLDKDLPFSQPVTFAHLPWHRCFSASHTSPLDIAIVGFPYDTSTSYRPGARFGPRGIRAASSREKKGRSYNTVWGIDPFTDGGLNIVDCGDIPITPFDAQHAFRQMEQGYRQILYHNTSTSTSTSNASSGMSSLNEWSHPRILSLGGDHSIVLPVLRSLKTIYGPISVIHLDSHLDTWDPYAGYTGIVSEQSAITHGTFFWHAAREGCIAKGSSVHGGLRTKLFSPADYETDKQVVGFELIEAHEIDDDPRGMSGIAARVKSIVGTMNPVYLSIDIDVLDPSIAPATGTPESGGWTTREVKRFIKGLEGIRLVGADVVEVSPPYDTVAEVTSVAASDLLVDIMALMVKDSLGKADGKDTVGDGEVRRKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJP7</accession>
    <name>A0A1C1CJP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tachykinin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJP7"/>
    <dbReference type="STRING" id="86049.A0A1C1CJP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04892"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03212"/>
    <dbReference type="eggNOG" id="ENOG502RW5T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4464164at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF10">
        <property type="entry name" value="SIGMA-70 REGION 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="51045" checksum="B2256B5E455FADE2" modified="2016-11-02" version="1">MERPSRKALVPVKKELVSIEPKSTPPADKLPQRHEADNKAKPRAKAFKDLPLEEKLLEIVRHSVRPFSDRLDPFAALPVTLDRFQEHLISFYLLYYPKATYGFSPRLRPHPVASNFSIALTTPACFQVIMARSALYRISLNKYATEAERSSLELAVVRHKGEALKLVRLLSSKLTPKRKDDLLASIISLGTFDRRSGSPEAASMHYQAVRRILKSTGGPLAVNSVLLSRVMCFFECIYGTSPESYIWDESDVQRLVHGLNGFLKKLREFWQSLSTINALTARLAADEDGVARDLTGKEAEPRPIHSFGIRPGSTLLGLVARQPPPTAELTQQRRLEMIFQLTCLLTLGMITMDLANDFRALQAYMDGLHASIEKLQLAGLSCNNAMWQIQVNDHSEPHSRRIWRAASFAWVMKHCTYSVQLTLKDWLLAFFTGKPVQKPYRLDPFHFSYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJS5</accession>
    <name>A0A1C1CJS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3669 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05022"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03173"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022137">
        <property type="entry name" value="Znf_prot_DUF3669"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780:SF3">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12417">
        <property type="entry name" value="DUF3669"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3669" evidence="1">
        <location>
            <begin position="216"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="308" mass="34920" checksum="341F1EAC4A350BC2" modified="2016-11-02" version="1">MGSGFCGTVWAAEGGKVAMKREDGGPGRSLLNDYNMHMLVFETASQQKVSVCVPRWPEFFKSEDGWWGMNLARSPPGYTPCNVLCAERIPPLPQEVRHRLIDRYCPPAAIATIKANDADRDCLVRPYLGRRKIQNETRRGRNFFSLRNYPLHLNQAEDLDLPILDYSHGMAEILAIMHWTAKIDANDIEFVLGGVQPQPEVARKESTHDFLGTHSLWVLDFDCCKPLTMDDAGIDQAARAFLRNDPYFPRPATSAQSPDSTLWLEFRTRYLECSQNFATRSGVTWLGLPEKFIARVAEMHQQGTEQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJT1</accession>
    <name>A0A1C1CJT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flap endonuclease 1</fullName>
            <shortName evidence="15">FEN-1</shortName>
            <ecNumber evidence="15">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">fen1</name>
        <name evidence="19" type="ORF">CLCR_04818</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="15">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="15"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJT1"/>
    <dbReference type="STRING" id="86049.A0A1C1CJT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04818"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03143"/>
    <dbReference type="eggNOG" id="KOG2519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 15 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="146"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="356"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="356"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCT48759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="395" mass="44976" checksum="C5A98AF0DC1810EA" modified="2016-11-02" version="1">MGIKHLYQVIADEAPEAIKTGEIKNHFGRKVAIDASMSIYSFLVAVRSDGQQLMSDTGETTSHLMGMFYRTLRIVDNGIKPLYVFDGAPPKLKSGELAKRFARKNEASEQHEEAKETGTAEEVEKFSRRTVRVTREHNEECRRLLKLMGIPFIVAPTEAEAQCAVLARAGKVYAAASEDMDTLTFDSPILLRHLTFSEQRKEPIQEIHLDKTLEGLNMDRKQFIDLCILLGCDYLDPVPKVGPNTALKLIRDHGSLEKVVEFIENDPKKKYTIPDDWPYQDARELFLHPDVRSADDPECDFKWEAPDVEGLVQFLVHEKGFNEDRVRSAAQKLQKNVKTAQQSRLEGFFKAIPKTEDQKKDLKRKHEEKVADAKKKKKEDAKTKKETKAKAHLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKM6</accession>
    <name>A0A1C1CKM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_05026</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05026"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02929"/>
    <dbReference type="OrthoDB" id="2587363at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF5">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650923" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="10">
        <location>
            <begin position="22"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="11">
        <location>
            <begin position="32"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT48982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="322" mass="35346" checksum="F9767090A7C88557" modified="2016-11-02" version="1">MGTVTSAVFLFFTLAARHIFAQDHGEEYSETMGPVAFMWPPDREWGAAQDNTAPCGSAAAVVNRTEFPLRRWQSHPEGYACLFVPVNGQIALVAQDESWSIQVAISHRNGKQTRASQAFLSSALTQPSDPSSNDDFETVIPAMRIPELNEGHMCYPIPNPSADIEAFSNATLQIRYTSDFEDDKNETYYACADITYVPTSQFTYQVPCFNATVEDFEISDADPEPSSSDTAPGSSVTSGAIEATEESSGGLSKGAIAGIVVGVVVGVAAFLGALIYMWRRSQQKRRLRQQEASLRNVKWDDHVQENNSASQISDRDIQLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKN1</accession>
    <name>A0A1C1CKN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CLCR_04491</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKN1"/>
    <dbReference type="STRING" id="86049.A0A1C1CKN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04491"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02851"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000003">
        <property type="entry name" value="Histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000044">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000285">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000579">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF46">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="75"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="16">
        <location>
            <begin position="1897"/>
            <end position="2118"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="17">
        <location>
            <begin position="2169"/>
            <end position="2292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="83"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="451"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="544"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2299"/>
            <end position="2349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2363"/>
            <end position="2443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2391"/>
            <end position="2405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2432"/>
            <end position="2443"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="2223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT49070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="2443" mass="271750" checksum="1F580449D639692E" modified="2016-11-02" version="1">MEDILGEDLPIAPARLFERLSQVPNYTWDRSCERHRVWIRKSRNPATDDRCPNRHIYGILHNPEVINPRESASTLTSFSLLSNGSTKSSPKLDPHRPSLRHHHWSSISGTSDSDNLSSKGGDPDPIWMPVVARISTHVLRLEREFYYNQAVVKEADPECEHTIRPIEIFKLPSTPGDTRPIVVCVYEAPGKNYLREILDMGPAFYGLNNRLEQKMGLSDGTPGEQIPLQAFLDFAVGAAETLELLHHGAKTVHGEVRSDTFHWNRETGAVKLANGGNGPRAFENLLSSEGWASMSREIGVKNKLHFIAPEQTGRLPAEPDSRTDIYSLGVLFWTLLTGQPAFDAETPIDIVQRVLTHRLPMVTSIRMDIPDAISHIIAKMTHKQMDERYHSMSGLKYDLLQIQKFLGEGDQEKIKNYKVGQRDVSSFFILPTKQFGRHAETERITKIIDRAHKRQSSSASRPGPSQHGLLSGSNSSISDSRVDGPEEGAPSDDSSSFGFRESRSNSTTIGLDSTYPPGYGNKANLFGKRTRAIADPRITPLDVLSDRDSNFSGGLQPPTDSLPGMMTRRRNSHKYKRRSKTEVIIIVGPAGVGKTALIKAVQPAIRRHGYFALGRFDRARPSPFEPLIKVMASLFRQIFSEKDVNSPYHEHLRAHVAPFWPVLHTTLDLPATLLDVTVLSKKLLVKTDTANQSINTEVPTIENGSRPTVSPSATHGTWDANDFLRGPANTKSIRLINTYMDVLRTICTGKLICLCLDDLQYADGESVDLLMHIIKAKVPVVLMLSSRVDDDGVPEPIAKLLDLDSSNKIELANLREKHVFEYVAATMSQSVDTILPLGAVVYAKSEGNPFLFKDILQTCYQRNCLWYDWRASGWQFDLDKIFDEFSGEGCTDNGYLTRRLQDLPPAARSILAWASLIGSTFSFKLIQSIMTGDFFYSSGRDQAHDATCPKRAKLFNLSETDCVNGLQQLVNMYIVTPGETDDEFRFAHARYLKAANEMRECQNTTKMHFIIAQAMMGYLSQCKYNLYPLARHICLSAQIVKERVPTRMRYRDVLWRGAQKAVEAGAKTTALRYYKTALDLLQDDKWDTDNPDVFYDETLQLHVNTAEIMYLEGDKEGALELLNETFKHARCSADKTRSFILKGRVLAAQGKFLDAFAAQRECLAELGLVLTQPTWDECDIEFKKLEFRVRQLDKEALLTAPLSEDKNVIALGTVLSEALGALYWSDALLWYQLVIAYVNALLDRGIFVQAGVGFAMLGAAAIGRFKDIDLGLSYGDLAQEFFTVFDDAWSRGRGWTLYTLFIGHYQTPVRNLLPILDSALEYSLSSGDRFVSILNIGVMAISRFWAGQDLAEVEAFCTYGPEEFDNWERDRRGGTLLTITRQVSRALQGKTIAADARTLLDDEDHQTEKWMAECDLYAANAQRPRDIFAAMSLVAYHLLGYHEYVVEKGRQLLATTLDELWSNRPSCATRFYLGLSLVAVAKEKPEEERGPYIEEAKKMKNFIDEWGSVNDVNYFAWSRMLEASISDVTREYYNVISNIEMAIDHCQVHGFALEEALAVEMQAEFLLARGAKRAGKVMIQEAIGAWNRINAAGKARHLQDKHEWLIKTATTSRTMDAATQTQDLHSLAVAEDPSLQNKREYTKQWVQPKPGAATQTQQDVPGLGLDILDLTSILEFSRVISSELQINNLLSKMISVILESVGGQAEFCAIVIDSEDQGWCVAASADHETGVKTYPDGIPFSEVDDQAAQQITHYLLRTKETVFVHNVLEDDRFSNVGDAYLARNPHGRSIIAIPIIQADHLMGVIHLEGRPNAFTQRNMIVLNLLTNQVAISLGNALLYRKVRKVSASNASMVESQKRALVAAREAEAKAKKAEAEAMHNVKLKEEAARAKSIFLANVSHELRTPLNGVIGMSELLKGTPLSKDQEQYADSIRVCADTLLTVINDILDFSKLEAGKMQMFTVPLNLKETITEVVRALAYTNQEHGLKTIEDLQIDDNLVLGDPVRLHQIFMNLLSNAYKFTPQGSVTVRARKNAETRDRVKITCSVADTGIGITQEQLTRLFQPFSQADSSTARSYGGSGLGLSICKAMIENVLGGKIWIESTPGVGTTVSFTLTFHKAPKNSSVVNDMQISAKDPDPMANWSQAASPETEHKTYSFCDLSKVPREELRVCIAEDNHINRKIAISFVKKLGFKCEAYEDGKQAYDALKAESKEGRPFHLVLMDVQMPVLDGYEATKAIRADPDPNVNRVLIIAMTASAIRGDREKCLEAGMNDYLAKPVRQTALKTMLDEYIKNSKGVTEAADKKGNSPAVPGDSVDGPTDAGDKPPELAPNGTPTTSPTENPKIRRPFKRVMKKVEAGIAEVSEDANRKLRGAAAEQDASHGPSPPSGKRATDELGKISSDHVMPKAVLDLSTNGINGHASGDQNGIPLPLKEKSGNMDRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKV5</accession>
    <name>A0A1C1CKV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NFX1-type zinc finger-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_11301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKV5"/>
    <dbReference type="STRING" id="86049.A0A1C1CKV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11301"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02792"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02793"/>
    <dbReference type="eggNOG" id="KOG1807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF445">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="508"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="874"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1740"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1795"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1745"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1803"/>
            <end position="1868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT49133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1868" mass="210508" checksum="1C47A10C60B72510" modified="2016-11-02" version="1">MEAPDEHYDPSQQACETLCLGPKGMKTYVGGSGIDDCSLLNGYTNDHLSATASRQVTFDAMLIQMLTVCDGKNDVVRRPFVHHDLCIILENMMQQRTSAALSNHVQQIVIYSAKTLLSRAQSRGDIKRSGPSETINGMAMIRAYIPPGPDGLPPGRVSASVLCPDPRPPLSFTDDGPGRLSQLGPRHDNDHDDFRKIKILPTPDEILAVDRSVYMPKKDLIEKHFLNNGPGRHLDTLFRQLRCDSTEMIRDICYSAAQIAFLKTGSGSEAHVRQETNAGHRYFLYRNIKVQELLSHEHKSMVVRVSYDCPPFMRGRKLYEAGHFQRGMLVALLQLNNTTMEFSVYYMEVSLAQTTFSMDAFDGRGTQAAVQLSFLPTSSHDDILQICRHALGLKTDNELYLVEFPKVLFAGFYNCLKCLQDMKDSDFAFSQYVAPGIHVEDALLARELNSAVGLPSYFPCLPPSYARAPDYKYNLAKIVGPHSPITSVSLEDLCRPSTLDILKRETTLDEGQAMAFRDSLVRDFACTQGPPGCGKSYLGLKVAQALLESRTAQKPILLVCLTNHALDNFLADLRDAGVSGLLRVGSGSKEEWTDSINIRDLRRKTRFRREEFNVMHTHGLQKKESIAGLDELSVSCQTHTGAAPWHYVRDVLYSDHQDIFTQFTTTAKVPLAQSFTFEYWSAGGDLETIRDLHLELANRLAQVSASHDKRPEEDVDKLLFDLSWDAELQSFSAGLSSIWNMPLAERQSLIKSWEKQVDKGALAQKMMSLYLESQHHEREIKRIQDERDGRIMAAHNIIAMTTTACAARWGVLRSLDLQILICEEAAEVMEAHTLCSLMPSLEHAIFIGDPQQLRPEANEQMLSLESRIGRQYRLDESLLERLMMPQDVSAYSLPASHLSIQRRMHPQIADITRLTYPYLKDHESTHVRSPVQGLAQRLFWWDHRIPELESDDLKSHANLHEVEMVASLVEYLLRRGAYEQAEIAVLTPYAGQLLRLYKRLGATCDIWLSEKDRAALLEEEVLALGEKGRTTKDEVVMSNMLRIATVDNFQGQEAKVIILSTVRSGGKAGFLKTLNRINVACSRARNGFYVIGNSQTLSQVPMWRQIIQVFNGRIGASIMTLCHAHPEQNQLVQQPEDFATVTECSSSLSTTSHLNVDTLDSVFVPEAFLRAQPLPPANNYLVATMPIFYVDKIQTPMLSANSRVERGSLVSTRARTYVGIATAMRRATRRVLKSAVYQKHVITNARKFVMVLARPARQDALNHVLTAVSMGHVRAAVETLVTPVSSKPFLAATTMQQTCSVAYRAYHYHAPRDVRRLLTVVTLVLHWKARHVRLRRSVQSCGHSVEVSQLDTINLCGVYKVDTNGTILAINADIRLPSLDEPRCVCGAPLEGTRRYRIHSKLIRFNSTLDLLLAKLGRKLANFGPAVDTLEKQLDETFEAFVEAIRPNPLAAKANAALLLRRSREILDLQNQITDFRKNVVDLVQRDLARLNNAFPNIVPSYTLMFHLHFDVLGYRVVSVRLSDVLKLGNQLLKLQDPSFSVQRQGLKMIQFVHRESIAWVGLCKHALADQLLVTNPTLEAEIRLQQLQFVVFAKSTRVQLVQLGNPVEDTALAMDEGAIKTSLDIATKLSRSSSRTCAPFGQSARDFADIFAAANEVSTSSPMIPAIKNAHVREIEKLWGQHKLGHLKTCAKSHIYSSKTFCDACPECGKEASVSSNEIFRESSKHLFESQFLAAMHARSASSRHVEPSKAESPETERRPSNGQPVLEEEVPEQPDRELTQEERFLKAMRNNLPKIDGSLKQKQKQKQKQKQKQKQKQKQKQKQKQKQKQKQKQKQKQKQKQKQKQKQKQKQKQKQKQKQKQHRLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKZ2</accession>
    <name>A0A1C1CKZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MIP transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_04918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKZ2"/>
    <dbReference type="STRING" id="86049.A0A1C1CKZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04918"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02769"/>
    <dbReference type="eggNOG" id="KOG0223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT49157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="395" mass="42081" checksum="93E87880C1679DE6" modified="2016-11-02" version="1">MTEPFPQAPDEIDPKHPFQSAQSPPPAPDLRPWRSQPSTSVTSAPVSTIPSRSMSTATAARPNLACRRRRGTLSSPFAGRLGGNQEFTVDRTDPQNEELLKKVPDAAPNLTLQEAFDLNGFREIGLWKASLIEFIGTLLFVYASAWDSLSPDTPPPLPSETLGPFNRVSFIGPLVANVINAILLALLIFSFGAVSGAHFNPLITLGTFFARLTTFPRLVLYLGAQITGGTLAGLLVRASANTREFKCGGCYLFTEQGTPVSSAFTVEVVGDLLLLVLAFGVGLDPRQREIFGPALGPIFVGLAAGSMALLTAYSLPGYGGAGLNAARCFGVFVGSRFPGWHWVHWVAPFVASIFHGLVYFLVPPGDPMGGDEQTIASAGQKRESGNGKAKGREPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL01</accession>
    <name>A0A1C1CL01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_04995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL01"/>
    <dbReference type="STRING" id="86049.A0A1C1CL01"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04995"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02747"/>
    <dbReference type="eggNOG" id="ENOG502S2NN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="32006" checksum="36CD3B6AC69525F2" modified="2016-11-02" version="1">MWPFPNAGEKGKYTPIQGGESFSSLDSEEVQSPLRFPSQPSWATKRLRCLPWATTLLFASTTVFLSMTQRSAPTLGSFDRGWATDFITVRSEIKAERITFNGSPAFDENKTMFVPNPDPVRYVGPPSPEIDKNWEKLTWGRYFLITEEEARASWGDEIEEYWDEQRGGYVTGLDVFHTLHCLDNMRKALHPEYYGDGKANQNHDMHQDHCIEHMRQFIMCSGDMTPIPTKYYPALGRNYVDSDRPHTCRNFEQLRQWMVDRYEGPTAVQPRTRSASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL28</accession>
    <name>A0A1C1CL28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_05280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL28"/>
    <dbReference type="STRING" id="86049.A0A1C1CL28"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05280"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02724"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF5">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="105" mass="12332" checksum="FA81B7D11DAF7515" modified="2016-11-02" version="1">MATDALSRYRGNSHLGGGSKFVIVLGANEGGGVMEWKGPREWAIERDSVKNKKRYADRWGYHLDIADMSTKKRYAHEWRESWEKVDLIRNAMARYPRAEWYLHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLA3</accession>
    <name>A0A1C1CLA3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kynurenine formamidase</fullName>
            <shortName evidence="3">KFA</shortName>
            <shortName evidence="3">KFase</shortName>
            <ecNumber evidence="3">3.5.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arylformamidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-formylkynurenine formamidase</fullName>
            <shortName evidence="3">FKF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_04902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13009"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="3.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the kynurenine formamidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.9" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLA3"/>
    <dbReference type="STRING" id="86049.A0A1C1CLA3"/>
    <dbReference type="ESTHER" id="9euro-v9dgt0">
        <property type="family name" value="Kynurenine-formamidase"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04902"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02643"/>
    <dbReference type="eggNOG" id="ENOG502S28Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03014">
        <property type="entry name" value="KFase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027519">
        <property type="entry name" value="KFase_ver/fungi-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT49298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="411" mass="45542" checksum="B1115139B622514B" modified="2016-11-02" version="1">MKKVFKYLQNQALEASQQRYSGSSYLSPPTKEPQQHGGHHSPSPYRDQHNLHHQSRSAHPSSAAHSFPAHSATGTSLPTANGQREMSPPQIPDKILRGITRHQYAQDNILQSYELYIPEVDHKHQAEANANKYWVIYVHGGYFRDPYVSSSSFYPALGILASEHHRRHIFKNNGPPSHPGDITPYIAGYATVNYRLSPHPGKAPQDPDTTPAYELRNAKWPEHIYDVLAAIAHLQNKYGFGERYLLVGHSVGATMGLLSVLAAEKAPFSTVSGLEMPTIEPPMAILGVSGIYDFPLIHESVPDYVGLTRNAIHHEADVALASPAKYTAKDYVSSWTGGGKTKRALVIAHSRDDGWVDWKQPEAMENVLKSESAIDVRVSEMQGQHNDIWEKGTELARVVVEAVGVMRGLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLE0</accession>
    <name>A0A1C1CLE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 10">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">uba3</name>
        <name evidence="12" type="ORF">CLCR_04886</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 10"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLE0"/>
    <dbReference type="STRING" id="86049.A0A1C1CLE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04886"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02624"/>
    <dbReference type="eggNOG" id="KOG2015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="11">
        <location>
            <begin position="352"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT49316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="436" mass="48281" checksum="ABA5FC2F5EF8FC40" modified="2016-11-02" version="1">MAIPISSLLTNGTPTPPRERWTYLDRILSTTSPYAGEEFVPGEETIDVLESSRVLVIGAGGLGCEILKNLAMSGFKDIHVIDMDTIDVSNLNRQFLFRQSDVGKSKAEVAAAFVERRVPGVKITPYNGKIQDKDEDYYMQFKLVICGLDSIEARRWINATLVDMVDMENPESLKPLIDGGTEGFKGQARVILPSLTSCIECQLSMHAPRAAVPLCTLATIPRQPQHCIEWAHIVAWEEQRKNDTLDTDNPEHISWLYSTALKRAQEFNIPGVTYSMTQGVVKNIIPAIASTNAIIAASCCNEALKIATSCAPFLDNYMMYTGDSNEGGLYTYTFAAEKKDDCPVCGNLAQTVTIDPEWTLEEFLASLAQRAEAQLKKPSIRSEAKTLYVQAPKSLEEQTRPNLQKKMGELVSDGEEVGVSDAAFTISFKFRLVYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLF4</accession>
    <name>A0A1C1CLF4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RPC40</name>
        <name evidence="8" type="ORF">CLCR_04946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLF4"/>
    <dbReference type="STRING" id="86049.A0A1C1CLF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04946"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02623"/>
    <dbReference type="eggNOG" id="KOG1521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="63"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="373" mass="41506" checksum="F0455C8AB81B3BC5" modified="2016-11-02" version="1">MAPIQPSQDSLDRRKLVGINAETVTNITSTDFPGHHAGEDNSWSLEKFKDTFKIVFYQNQKHEATFSLIGVDASIANAFRRILLAEVPTLAIEKVYVQNNTSVIADEVLAHRLGLVPLIGNIQALKKLTPFVQTDVDTVAHVTELTDTNTIVLSMKVRCERNPNADKNATEPEDKYINSNVYSRHFEFLPQGMQAASFGDEPIQAVSPDILIAKLRPGQEIDVVMHAHMGKGGDHAKFSPVATATYRLLPTITITQPILGTDAIKFQQCFPDGVIKLERVTPAEAQGNTAAYHHHEGDEKAVVADVMRDTVSRECLRHDEFKGKVKLGRVQDHFIFNVESTGQFPSDDLFLQSVNILKKKAKRLLKALDEMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLX6</accession>
    <name>A0A1C1CLX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_06603</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLX6"/>
    <dbReference type="STRING" id="86049.A0A1C1CLX6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06603"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09756"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000001">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000015">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="3"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="95"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="187"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="279"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="371"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="445"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="14">
        <location>
            <begin position="825"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="959"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1029"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT49493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1041" mass="113471" checksum="B9C585676E83A53A" modified="2016-11-02" version="1">MAANLTDQVREIATVTKAVARGDLSQKVQSRAKGEIFELQHTINTMVDQLRTFATEVTRVATDVGTEGVLGGQAQIEGVQGTWNELTKSVNAMADNLTTQVRDIAGVTTAVAKGDLTQKVTASCKGEILQLKITINNMVDQLQQFAQEVTILAKEVGTNGVLGGQATVHDVEGTWKDLTENVNGMAMNLTTQVREIATVTTAVANGDLSKKVTANVQGEILDLKITINAMVDRLNTFAFEVSKVAREVGTDGTLGGQAKVDNVQGKWRDLTDNVNTMASNLTNQVRSISDVTQAIAAGNLDKKIEVPAHGEILTLKVTINNMVDRLATFAHELRRVARDVGVNGKMGGQANVHDVSGRWKEITEDVNTMAENLTAQVRAFGEITDAATEGDFSKLISVNASGEMDELKRKINQMISNLRDSIQRNTAAREAAELANQTKSEFLANMSHEIRTPMNGIIGMTQLTLDTDDLKPHSREMLNTVHNLANSLLTIIDDILDISKIEANRMAIEAIPYTVRGTVFNALKSLAVKANEKSLCLAFDVDNSVPDYVVGDPFRLRQIILNLVGNAIKFTDQGEVKVTIKKSRDLISNCATDEFPFEFVVSDTGIGIQSDKLDLIFDTFQQADGSTTRKFGGTGLGLSISKRLVNLMGGQVWVTSDFGHGSEFHFSCIVKYATDDISVISSQLYPFRKHKVLVVDKGVSNFFDRVPDMIEELGLHVQVVKSETEVPDPIAAVDRKGRNSDGGYDVIVIDELETAQRLRELDKFKYIPMVLLNPTVSISLKTVLDLGIASYMTTPCQLIDLGNCLIPALEGRSTPVIKDYKKSLNVLLAEDNEVNQKVAIKILEKYNHVVTVVGNGLEAVNAIKNSRFDIVLMDVQMPVMGGFEATREIRQYEKEQALPRTPIVALTAHAMLGDREKCIQAQMDEYLSKPLKQNLLMQTILRVASDRVTDIFHEQARSKANGIGDGKSGAAEDRPSALPLKISRKSKDPSSGLRPPFSERSITTSGSVIHGSAESPSVGRDGEPDPMSVANSSVRSMSWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM43</accession>
    <name>A0A1C1CM43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 21">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="15">IMP dehydrogenase</shortName>
            <shortName evidence="15">IMPD</shortName>
            <shortName evidence="15">IMPDH</shortName>
            <ecNumber evidence="15 21">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CLCR_06864</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world. Does not play a role in the biosynthesis of MPA, but is involved in self resistance to MPA, since MPA acts as an inhibitor of IMP dehydrogenases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15 21">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15 21">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15 20">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="15 21"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM43"/>
    <dbReference type="STRING" id="86049.A0A1C1CM43"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06864"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09782"/>
    <dbReference type="eggNOG" id="KOG2550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15 21" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 15 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 17" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 15 18" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 15 21" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="138"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="201"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="15 16">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15 16">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <begin position="295"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <begin position="345"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="385"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="408"/>
            <end position="409"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="433"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OCT49521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="548" mass="58260" checksum="2EBF24ED1F8293B4" modified="2016-11-02" version="1">MPTANGDVASGSPISRKVEVLDYRKALQVLESAYESRDGLDIASLLNSKENGALTYNDFLVLPGYIGFAASEVALDSPVTKRISLKTPLLSSPMDTVTEESMAIHMALLGGLGVIHHNCSADEQADMVRKVKRYENGFISDPIVLSPKTTVGEAKELKEKWGFGGFPVTESGQLHSKLIGIITTRDIQFHPNADDSVTEVMSKDLITAPSGTTLAEANDVLRKSRKGKLPIVDAQGNLVSLLSRSDLLKNLNFPLASKLPHSKQLIAAAAIGTRPDDRNRLQKLVDAGLDIVVLDSSQGNSMYQVDMVKYIKEKYPQLDVIAGNVVTREQAANLIAAGADGLRIGMGSGSACITQEVMAVGRPQATAVHAVASFAARFGVPCIADGGIQNVGHIVKGIAMGASTVMMGGLLAGTTESPGQSYINREGKLVKAYRGMGSIDAMEDKKAGGGVKNSKTNAGTARYFSEGDRLLVAQGVSGSVLDRGSVTKFVPYLLAGLQHSMQDIGVKSLVELRDEVNSGKVRFELRTVSAQAEGNVHGLDSFEKKLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM56</accession>
    <name>A0A1C1CM56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07830"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="81" mass="8975" checksum="3563AEAF48F986CD" modified="2016-11-02" version="1">MAKIFSLRNGTSKDTLESHARKTRLSTWRLEAQPRSIPQAPLRGRERPAVKKVVNHLLAEFIVIAAAAAAVVVPDKVQKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMU2</accession>
    <name>A0A1C1CMU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">cch1</name>
        <name evidence="23" type="ORF">CLCR_11331</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Voltage-gated, high-affinity calcium channel that functions together with MID1 to mediate calcium entry into cells. Required during conditions of environmental stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 19">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMU2"/>
    <dbReference type="STRING" id="86049.A0A1C1CMU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11331"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08757"/>
    <dbReference type="eggNOG" id="KOG2301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000093">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000118">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000063">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000079">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000098">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 19" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5 19" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9 19" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="416"/>
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    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="723"/>
            <end position="748"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="788"/>
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    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="904"/>
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    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
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            <end position="1013"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="21">
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    <feature type="transmembrane region" description="Helical" evidence="21">
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        <location>
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    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="1806"/>
            <end position="1841"/>
        </location>
    </feature>
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    <feature type="region of interest" description="Disordered" evidence="20">
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            <end position="2133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="2001"/>
            <end position="2010"/>
        </location>
    </feature>
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        <location>
            <begin position="2023"/>
            <end position="2035"/>
        </location>
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    <feature type="binding site" evidence="18">
        <location>
            <position position="1441"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057587"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061395"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067459"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OCT49834.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="2133" mass="238296" checksum="DD5279E1586E37B4" modified="2016-11-02" version="1">MSSRDRTPPKAIGPQSIPLRDLSRPPDSGSDETDDLGSATVGHKKRHSRTRSLLAGRRTPNYARLNDHEESPTRGGPSGAPNRLVGLSVRGGGGSDTHSPVEDIGGFAAATVGLDLQLPSTPPSVGLRRPSIITTAAEGEVHEADSPFSPPDSDTTPLTASQRLTSSLKTSSSTSRGQRHDRQGKGSSVHWTDGESPSFVRGRASRLGDDLPTLDTGAGMHRKLSTGSGISRLSASRAESGERSRSLSPSPSPMARANSMLREISQRVVNLSNDSDMVEQSIRRKSSVRQHRRPSTTSPALPLPGIEDEEEAPPHQAPPLEKVPSAEVTAEPFTPFTPSAPSTPAYHPNPLLGRSWGIFGPENALRKWLCEILVHPLTEPLILVLIVAQTVLLAVNAASDAVYLETRTKRWGSTGFDYAIFGLFVVYTLELIARTIVSGFISNPVQFSTINRSVGLKKAVLQKAHTLFAPQDAREAPRMANDGPTQPSIVRSFTGLPEPGGPGHTKQQQRIRLARRAFLRHSFNRLDFVAVVSYWISFVMQISGVEDSKHVYVFNMLSCLRILRLLGLTAGTSIILRSLKKAAPLLVHVAFLIGFFWLIFGIVGVQSFKSSLRRTCVWVGDDGSGQNFTLNIAPDNIQFCGGYFDAVTGDEMPWLKSDGSQGANSAKGYLCPQNSLCVESGNGPYNGTVSFDNIAQSLELVFVIISSNTFSDLLYYLTDSDYLAAALYFAAGIVVLSLWLVNLLVAVITSSFQIIREESKQSAFTADKIDGPHLDEDLKTKRSQLKKIYDKTHIFWVLVIVYDLVVQSLRSATQSPSRESFIMNSESVVTFLLLLEIILRFLCDWRHFLHGKRNIVDLLLAIVTAVMQIPTIRNSGRAYAWLSVFQIARIYRVVLAVRVTRELVMVVFGNIVGLLNLILFVFLFTFLAAILASQLFRGDFPPADAGGELINVTFFDIWNSFLGMYQVFSSENWTTLMYNSTQFNNIWDTAWLSAIFFILWFVVSNLIVLNMFIAVIQESFDVSEDEKRLEQVKAFLRQKEMTGSASGNLSLAAVFKMGRESLRHRDALEYGSAAVEQLLKEAVVKDFLDEQDQGLARRPTSMHLDQIPTVKPGFLSKYWGKVTGLAGTREPNPFYSNATVSRANEDFDPRLVAQRVVATAENRRRAQRQYLQKHPKYNVSLFIFKPDNPIRKLCQYLVGPGRGSERVEGVSPFKPAWYAFSAFTYLAIVAMVILACITTPLYQRDYYLENSLSITNWFVWTDLGFAALFTIEAAIKVIADGLFFTPHAYFRSVWGFIDGVVLITLWINVITAMFRDDGVSRAVGAFKALRALRLLNISDTARQTFYSVIIVGGYKVLAAAFVSMSLLIPFAILGVNLFNGQLEACNDGDFGYSALSNCVGEYNSTPFNWPVLAPRQVANPWFDFDDFGSALFILFQIVSQEGWVDVMWSGTSITGRGTQPEPLASSGNAVYFIIFNLLGAVFVLTLFISVFMRNYTEQTGVAYLTAEQRSWLELRKLLRQISPSKRSLGVESNKWKKWCYDLSIQKRGLWQRFITLLLVFHLILLTVDFYPEPEWWSKLRKFIFLAITLVLIANIVIRIVGLSWNRFRRSSWDLYSIFSVSGIFVTSLISLSTIDNRAFEQLQKLFLVSATFLLIPRNNQLDQLFKTAAASLPLIANLLATWFVLFLVFAIALTQAFGLTRFGPNESNNVNFRTVPKALILLFRTSIGEGWNQIMEDFASIEPPFCVREDSFFASDCGSAGWARALFIAWNIISMYIFVSLFVSMIFESFSYVYQQSSGMSIVSRDEIRRYKQAWAEFDPNSTGFISKEQFPRLLGELSGIWQMRIYDGDFTVRAIKEDCSIQPGDPVRPPGRVVDGLDLDKLAERVNQIPVKEIQQRRARLNVFYEEVMLTADPDRGIPFTAVLFLLTHYNVITDSRSLRLQEFLRRRARLQRVQETIRRNTVVGFFDTLHWSRKFKKAVERRRSGRLAAPPSLPVPEIFIEDPDDNMEESSFTEPRDFTESRQSYTPKKQSVNLPPIDTSLPSGSSLRSPSPIDGSPASSPIRTRLGSVDTSYHGATRSSPTTPTLSHSRQASNTGQLDGQGMMESFDNSAWGESIRRSFTTRVRHDTSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMY4</accession>
    <name>A0A1C1CMY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMY4"/>
    <dbReference type="STRING" id="86049.A0A1C1CMY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07642"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08805"/>
    <dbReference type="eggNOG" id="ENOG502SAET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="192" mass="21350" checksum="5ADAAD142B0E76B7" modified="2016-11-02" version="1">MAQSEYKIAMLPPPGDVVAPNGFPADPRPKNAPVIFLDAMDLRIEVFCDEQHCALEPELDEDDLRSWHWVAYRTTESGAEEAVSVIRIVPPPHGPHPNGVSDPDEEPYVKLGRVATKANHRGKGLSRLLTEEAFQWLAANKGEVAAGYNGLVLCHAQVSVEKMYAKLGFVTDQKLGRWDEEGIEHLGMWKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN06</accession>
    <name>A0A1C1CN06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN06"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07728"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08744"/>
    <dbReference type="OrthoDB" id="4159429at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650922" evidence="1">
        <location>
            <begin position="21"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="144" mass="16430" checksum="41529507586C5B93" modified="2016-11-02" version="1">MKLCTTVLLAVAGLLTTTQCAPNPNPGPALAARQSYEIYGLWAYEGDYYLNNLYDWLFKLVKRDGSEHAGPSAIERSAHKRDDEDLHLARLLAARQTYEYAITVDSYEAIYEFQLWLEDFLYLVQQYGTPIKVTDPKLPQPKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNA6</accession>
    <name>A0A1C1CNA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative Cytochrome P450 oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_06956</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNA6"/>
    <dbReference type="STRING" id="86049.A0A1C1CNA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06956"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08903"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF24">
        <property type="entry name" value="LANOSTEROL 14-ALPHA DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT49994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="524" mass="59425" checksum="06FDF5EB02FE4AD3" modified="2016-11-02" version="1">MNSTLADPNGLLLGSTGESGYGTATLTYGVAAFATTLLSLIAIVSYQPRVHEKSPAFTRDTSPIIGSLGFLTRQWSFWKSSTDGLTKNFSFWLGSRHVVGITGQAARRMFYDNPDLCFVSQAIIQPFGVHFLPPVHAIFKAGFHSGHNNTFFLRRLMGLMKTEELKKVLPNALSDVHGDLESLVSNGQKSSVTSAPDIWRTVFKQNARLTFCDEVVDDAKLFERCAEDVGTLLHTYSHYNVLFSWLPAPSYIKRRLARRDLVQLVTQMVNQRIKENTPSKDDPLQRLINNRDNKEHIIEFFVSILFISTTNGHAIAGQLLNIMAIHPEWQEKIYQEIKAAVQAHGKFQEGTLAEKLRLLPLEAWETSFPTINMCLKETIRMWTSFTVTRLNTSSKPIPIPDTDEVVPAKTFVIYNSTEVNFSEKLYPNPTKFDPERYNEHREEFKKETYGFLGWGQGCHACVGMRWAKLQQTIIVATALAMYQWSSCDANGEPDPYVKHRRILDSDHAFHLPPAYCKVVPREVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNI4</accession>
    <name>A0A1C1CNI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-type cation-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PCA1</name>
        <name evidence="10" type="ORF">CLCR_06619</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNI4"/>
    <dbReference type="SMR" id="A0A1C1CNI4"/>
    <dbReference type="STRING" id="86049.A0A1C1CNI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06619"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08919"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056236">
        <property type="entry name" value="HMA_PCA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01511">
        <property type="entry name" value="ATPase-IB1_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594:SF4">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24534">
        <property type="entry name" value="HMA_PCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="580"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="618"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="928"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="953"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="182"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT50011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="981" mass="104338" checksum="8B49587AC4FA709C" modified="2016-11-02" version="1">MACVDQQDACPSGPTGTEIEKNTRHVECSSAPLHVSEQKSANHSRINAPHDHAPGEDGSHLHEPCSAHLKAAMEKYAAYLESARCICRNILLSAARVESCCPRSSVGGVTALGTSRRHHLEPRGLESISTRCCPKKPSVHSASAQAKIKCCDKSQDVDNIVRQPRAGAKVTALDIEKAGGLSHILLNVAGMDCSGCANNLTRALHDAAGTKNVNVIFINGTAEFDLDTEVNSLANVIRSAQQATRYKLTPFSSDTQSIVVTMDATEAAKFCGHLPRGVDHCEKLSKTTYEISYDPCIVGAREVLAGIHAQLGPPPSKSVADTGKRRLIRVFALTAAAFVLTTPVVVLEWGRPSGISEHTTLIIAVVLATMVQAIAVSEFYMPAMSSLIYNKMVEMDMLVVISITAAYFYSIIATGFFFAGVELETRPFFETSTLLISLILLGRLLAAWARKRAVEAVSLRSLQAPTAMLVDHRTGGAVEIDARLLQYGDSIAILPHSRIVTDAEVLEGTSEVDESMLTGESLPVFKTPGKSLVSGTINGGGRLVARVSRLPGRNTITDIANLVEKAQGSKPHVQDLADKVAGYFVPVVCTAAVIVLIIWIVVVLRLRKQPAGDAIGTAVGYCIAVLAISCPCALGLAVPMVLVVAGGVAARGGVIIKTADVIERGFRVTDVVFDKTGTLTEPSLEVVAEMINPTNQATEEVVLSIIMAMVRGTKHPVSEAVARALDGRGIQNIEIHGLASIPGCGVKAQWQGLTIRAGNAKWLKLGETRPVLEYAARGLTMLCVMIGDHQVALFGLKAKLREGAVGVVRELQRRHIAVHIVSGDAGRVVEDVAAEIGIPRENVAAEKTPAEKQEYVRQLMEAGKITLFCGDGTNDAVAVAQAHVGVQIESSSDVTRATADVVLLHSLDGVVSLLDVSKAAFRRITFNFAWSAVYNVLAILLAAGAFVKVRIPPAYAGLGEIVSVLPVIVAALTQPKLKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP56</accession>
    <name>A0A1C1CP56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP56"/>
    <dbReference type="STRING" id="86049.A0A1C1CP56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06754"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05703"/>
    <dbReference type="eggNOG" id="KOG3841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="718" mass="80222" checksum="0F35FA184115BA9A" modified="2016-11-02" version="1">MVNEQKARSRIRQQSVTAWGDDLDDVDDSLGAGGPNTDSDLSHPVESLNFEMWVSSPVDQERALHCYSKLKSDKLAAMPLEDLAGWRLSFPHLTTLVDRGKRLNDCDLILLNTSFKLMQEFPPRFSKLGIGLEVKFPDPLLWPESLGDVDLKMWTCTTYMYRDGILISDPTREECQVSEHWKVRPFFQSKWWASTFTSLTEVRKVAEDTKDPEAIEHAQEQSRSFFRGLSIMQEISAVRCVGRWQMKQDKRTRMAILLWKFTQADGAGTTTWQNLIAPPDRVTTNSPPPPGTEMDLPPLSLDSIVSPGNGSFESNNQFLSQHSMQYDVYPDAMDEELCQDGFMGLKPEQIGFSHLQSFNMSLHEFAGVDPALHDTFDLQHGAVRTTVANQHSFNGTLLEPPDAQAGLQSDMNGPLFDHHQAVTSRHTQDLPLSRFDVTTHRVLQERLNAEDSRHSASTSHSPSVRPESSPRLPSDVPEPRWSQQLEEDEKILHILAAQQQQQQQGQLAQTQTRQTWPSQVDEHQALRHALLGASGMTTVGATPGHHRASPGQHQFSSIGDQQQLHDERHRISLMSFRPPLHSYHSFPGIRSDDNLHRVSYGSEHHGDGLSLSQPLTRVDGHHFLDHQLSAVSAPEDFLRASNPLDAGSRDFTRAHSEPDTSVSAAGEYFSSSLHEVMTDAVGDSELQAHTEPSSLGPADTTVGMSPVEVSMQDVHGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPK1</accession>
    <name>A0A1C1CPK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_06971</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPK1"/>
    <dbReference type="STRING" id="86049.A0A1C1CPK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06971"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05577"/>
    <dbReference type="eggNOG" id="KOG0540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000007">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="7">
        <location>
            <begin position="72"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="8">
        <location>
            <begin position="324"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="572" mass="61631" checksum="BF9F29F51AD5EA8C" modified="2016-11-02" version="1">MAPKYVPTNSLLRSLNLALREHRHQRPSTFHLRSHCRSAATFAHRQYAQAISVLPTAVDKTSSEFKDNAAELGDIMSRYAALHQKISQGGPEKARKKHIERGKMLARDRVTALIDPGSPFLELSPLAAHEVYEDEVPAAGVITGIGTVEGVTCMIVANDATVKGGTYYPLTVKKHLRAQEIAQQNRLPCIYLVDSGGANLPNQANVFPDRDHFGRIFFNQARMSALGIPQIAVVMGPCTAGGAYVPAMCDESIIVEKQGTIFLAGPPLVKAATGEVVSAEDLGGGSLHSSVSGVTDYLAVDDAHAIVLARRSISNLNYPQEQAPPVEPREPLHDPAELAGIVGTNLRKQIPMHEIIARIVDGSEFAEFKKDYGTTLLTGFARIHGYQVGIIANNGILFSESSLKGSHFIELCSQRKIPLIFLQNISGFMVGADAERGGIAKNGAKLVTAVACAEVPKFTVVVGSSAGAGNYGMCGRAYSPRFLWMWPNAKIGVMGPDQLTAVMETVGKSVDVGLRDRIERESDACFSSARLWDDGVIHPSQTRDMLGMGLKAALGGKNKIEESSTRFGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ12</accession>
    <name>A0A1C1CQ12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GST-like protein YibF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ12"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ12"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07574"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05427"/>
    <dbReference type="eggNOG" id="KOG0406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03205">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="88"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="214" mass="24631" checksum="0A19C88083265ADD" modified="2016-11-02" version="1">MATSPRSPYARKVRIALAEKSIPFELVTDVPWDVTAQTPLHNPLEKLPVLIDTEAETDEDKAVYESHFILDWVEYKYPAPQYVNLVPRTKESDLFGKKVQVIADGICDACVLIFFEKQRVLPSQEWTARQRRKVDGGLKKLADWVVDKDFLIDDRITLADVAAGCVLGYLRVRFAEHPWQDLYPNLKRYSDLLEARESFRMTRPVPQAINDKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRB9</accession>
    <name>A0A1C1CRB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme E2 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">UBC6</name>
        <name evidence="4" type="ORF">CLCR_08863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRB9"/>
    <dbReference type="STRING" id="86049.A0A1C1CRB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08863"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09656"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180027">
        <property type="term" value="P:inner nuclear membrane-associated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="5"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="246" mass="26640" checksum="5305DD92FD4B1E57" modified="2016-11-02" version="1">MATSAAHKRLTREYANIQKSPPPFITAHPNESNILEWHYIVTGAPGTPTSTRLCLSISDFHPKSFNPAWSVSTILIGLMSFMNGEEMTAGSIGGTVQERKFLAARSRWWNSTGGGTASKPVPGVQRSIKGIGNVKAGDGGAKFRAEFPEEHEENVSWIHRHRIDPATGRMLPDAEGQEPINCSPETKALRRILGGSTGVGAVVQGGQAARNAGQGWIWRQKLWIFAGCVVMYVMLARIFGEGEGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRD9</accession>
    <name>A0A1C1CRD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08986"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09675"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="217" mass="23792" checksum="9BA9BE027D1495E7" modified="2016-11-02" version="1">MHKMSGKRLLLLSLARARKIRGYVPLALALALALPAPAEPRVVDMSCWRIGGPRGFRTGLGDCDGDDGCGSDDDDDDDAEHSVDRGWIMVPEEEEEDDEAVVGPADHDRGWIFVGNGYGRLDTAAKSAGLAVSSSHDGDNRDDRNDGCYDDDDDGDTDELSEREVYIRRESIESESESGQDHVAKRDWRHRTEAVKTLPDAEGAVDSRIFEGICDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRS6</accession>
    <name>A0A1C1CRS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative WD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_07960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRS6"/>
    <dbReference type="STRING" id="86049.A0A1C1CRS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07960"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06867"/>
    <dbReference type="eggNOG" id="KOG1539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="6">
        <location>
            <begin position="59"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="588"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="672"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="5">
        <location>
            <begin position="808"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1018" mass="110120" checksum="55D78F8EF36A5556" modified="2016-11-02" version="1">MDEAVELPLAKRQRREQGGTGKRPATSSRLFAPFRTLGLVSPTNVPFTSVPLGKTTFQITTSIGTSLQTYDLRRGLNLVFLTRPQCPSTITATFAYRDRVFVTWGGSQPKEPRGLWVFKRGQLVAELDIQHTHPQEIRQLIVFGSWIIGCGTESIEVWKSESYEHYTSISTGSGGSLAGQVCTLPTFLNKIFVGTKHGSIEVYNVSTGRLVHTILAPSARSGAVTALVPAPAIGLLAASYADGSLNIIDVEADETVLELRHSNNRKPITSITFRTDGMGAGEDGRKGGIMATSSIESGDITLWDLNRGGKVVGVVRGAHETSSLGQGTGVSKIEFLAGQPVLVSSGLDNALKSWVFDETPFSPTPRLLHHRSGHAASITRLKFLPAASDGSDATGKWLLSASQDRSLWGFSLRRDGQSTELSQGAIRHKAKKSGLLTDDASAVEDLKAPPIIDMACSLNRDGGMGSVTGPVWSNSKNVSAEESGMTGWESVITAHADDEVARTWSWGRKKAGRWAFETGDHKPVTSVAITACGTFAVVGSAGGSLDMFNLQSGAHRQRYPPRLTPAQAKQLKQQQQQQANPEQAAAVPRGHRAAVTGIVVDNLNQTMMTASLDGTIIIWDFSSGKIIERKSFDDAAPTAIRYNPVSGLLAISCDDLCIRVIDIETRKVVRELWGCTGQIYDYCFSHDGRWIVAGSMDSVVRVFDLATGHLIDAFKTAATCTNMAFSSTGEFLATAHAGSSGIFIWTNKALFTHVPTRQIDDIKGIIDLRQMPAAFNAASQLAIDESSVAAEEAEESLVDGMDVSSKLEQLDKSLLTLSLQPQSRWQTLLNLDSIRARNKPIQPPEKPKAAPFFLGTSASLANGGDTPSLNGPDPKAVDETERSRISRMAVSSIASGGDLSSLLEKFSQDAERDPAALATYLAALPPSAADLEIRSIALSEMPAFVTFLTAQLRARKSFELVNTWMNVFLRVHGDFVSEVDELRRAVKTWRDVMLEEERRLAELVGYSRGVVEFLRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRV2</accession>
    <name>A0A1C1CRV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GTP-binding protein ypt2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ypt2</name>
        <name evidence="13" type="ORF">CLCR_09019</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRV2"/>
    <dbReference type="STRING" id="86049.A0A1C1CRV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09019"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06871"/>
    <dbReference type="eggNOG" id="KOG0078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT51203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="210" mass="22800" checksum="A83162353B96821E" modified="2016-11-02" version="1">MAGQRNYDFLIKLLLIGDSGVGKSCCLLRFSEDSFTPSFITTIGIDFKIRTIDLDGKRVKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDEKSFNNIRTWFSNVEQHASEGVNKILIGNKCDWEEKRAVSTEQGQALADELGIPFLEVSAKSNINIEKAFYSLASDIKKRLIDSSKESGGAGVGGPAGGPGVSVTPNQGVGGGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSY8</accession>
    <name>A0A1C1CSY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transcription factor SipA3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_07899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSY8"/>
    <dbReference type="STRING" id="86049.A0A1C1CSY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07899"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06478"/>
    <dbReference type="eggNOG" id="ENOG502QU87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd07609">
        <property type="entry name" value="BAR_SIP3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13280">
        <property type="entry name" value="PH_SIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039463">
        <property type="entry name" value="Sip3/Lam1_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042067">
        <property type="entry name" value="Sip3_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="312"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="7">
        <location>
            <begin position="953"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="656"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="881"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="656"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1389" mass="154780" checksum="2916B1A85EA17A47" modified="2016-11-02" version="1">MAQALQPPDEVGRLINLIPVGLKEAAIDSPTARATVVHYGEQVDLLEKWLDEYAKAATRLAAESLTLENVLNGFIAHSILPTSLSESMLDHDYSVLAMKRYGDGAKDYWMSMIAVVKRLSSMVVDPIRQFLQNDLRAFKETRRAVEVAQKTFEHLQGKYAGLGKSKEPSSLREEAFQLHEARKVYIKAMMDFFSLTPQFRFALDRLLVKMFFDQWREMRMSRDNTAATFGRSADEMQRIRGWLTEMESSEKIFRSELLAAKKQLEDAAELETRPSRELEDYTLSTVPHHAGHGHSASTSTLQRSPKKIASKTGEKQGWLFLRTYSGKPTRTVWVKRWAFVRSGVFGWLLQSTTAAGVEESERIGVLLCNVRPAPTEERRFCFELKTNKNTILLQAETQAELVDWIDAFQTAKSKAVNDGDALPTMASGGGNLQAGAAFAISAPPVPEFGASILSSTQPGAGEDVPALEKTHTLPIPGTEHGRETSMDLSRRSTALEEVAQRDTASRILSKLDLHRKSPASTQVSPSPSTPNLPGGIAGLIAASHGSMPVGPSLPLVPNTEGDFPKPRSTFTLALRDMPASSLAPSTLASVPSPTNLSRSAVIITGERGLSPAPDKTGIPNGILANTWGTSCTAYVNRLERAESNERAEVKLLANRSPALVPSSSPPKALASPARSALPSQSPIPHLDLSIPQPGARSRTPSPSKRQHRNTISVDRVTAKQLSSELLVPEFPNYYPLQLKSQDAQFRLLFPSLRRDDRLVMVFRATWNPSEKQDFPGRVYVTPRDVYFYSNHLGLVLTSSVSLNAIDEATAAPGRDCDFIFLHLKEGTGDGSARRITIKTFLEPLRLLQRRMNFLIRNSVSDSPLGLEEIMKALIRMETETPDRSPSLESWEDVSPNTPVDTGGPRHRSRASTTGTELRAPLRIDRALHQTQLGRRDSKFKLPALPVKYTPPGNLRLAVEKEFDISAKALFHVMFGDKSILWQLLHRERQAKNISQGPWLSLGEGRFRRELTFNSPTVSLLGRESYTWVRDYQVIDVNSDHLCYVVTDKRTPWHLPYQNNHRLVSKVVITHAAKAKCKLAVFVKIEWLRPAWLLGGVVERQALYDLELDSQDLVDLVADQVSKLGAHSRTKKAIQIFGQVGHSTETTQLLMDAAAVNIELRRQPTTRSMTGLLAQSATSTAESVAATLLQSLLSILRWLARTFSANKVILAALVLSALYNSWHTYRDSLDWWHERKAGNFMARLGVSPDTVMSRAVYLSDLDEVLSRDAHLPAPDSSACYRVFYDEHDPQYIHAGRSHSPAAQVQQNRQRLGSHRHDLLVAVRVVNSVEKELMLAAWEQWVMAEHRRCQVVEGIVLGDLSQNSTDVGKELTDWYDEYCTSCRDEYMKIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTE9</accession>
    <name>A0A1C1CTE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_07953</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTE9"/>
    <dbReference type="STRING" id="86049.A0A1C1CTE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07953"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06338"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06339"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="274"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="4">
        <location>
            <begin position="555"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="953"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="982"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1023"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1035" mass="115655" checksum="4720C4404EE0FFC7" modified="2016-11-02" version="1">MVLEAIGAFALACNVLQVVEYGAKIVAKAGSLHRPSRESTTEITDLDAITQQLNNLNNDLGSSAVPAPSQACPLYARLAECNAESLQLSQKFIDFVQKLRPKTTASQGNPSWAASFRERPPSPSFDLLLSLRSSTQASGASQTALLAASNQFEQDMRLAIDDTSNKLHSDIAAVLQQLDHLKLQDSAYETHFAQFQASHADALLRLSVGIESIMLEQEAIRTRSDKQRAQLAQHRICVSLSFCEMTARQDQIREAHEDTYDWILAPCDTLDHGRSAFHSWLDAPAPDHSLFWISGKPGSGKSTLMRYLDRHLKPASCTNWLSGYGLFVCRYFLWKPGRGLETSFRGLLQALLHQLLHSHQWLIETVVSEERWLTACATESELQWSMPELKTTIEACLQRIATTRKILVLADGLDELDGTDDDRQDMLDFLHKLPRLGSVKVCLSSRPWNIFADSFDGLPQLQLHLFTRTDIEKYVSQSLSHSIRLQSSYLHNSGQGERLIQMIVDKANGVFLWVRLVVQELMRGFRDGETIRTLERKVGSMPADLDGFFKRIISSIDPAYRGEASALLQTALFCRQNSNKRWPCGLFELTFIEAGDPDFAMRPSCDFTELDVDDLDALNYRIALGKRRLNSRCMGLLELRTGESFPKGLSREDDVLYRRLDHIFSTKVDFLHRSLMDFLLTEDAQRILQQCTNGPFQAQHFLFSAMIAGVRANHAICAAHSRWDRSHSRGIVDFVAMSLSQKTNYLLDAIGRSKDLEPPTVNIIMGRLEPTLELLHRLSISGILGPGIDAFRWFRRFDRVEDLLVAMAIGYNLKGFVAEHLTRDKAKGISGPGLLESALKPQSPLVPDPEMVRIVLQAGVDPNYPRSIWWKSLHDVCYVILKLKQGKELLPSVAEIIEIMIEYKVNISCPADMLPEFDGFVEGDPETGILLLRDVVEALDFTERDRQRLLAALSEGGQAGAGKPGQAGDDDNDSGVDKGEGEGEDEGEGEDTQTKPTGASSARPRTIAALEQLITRKRKRETSSFADTSTRGRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTQ9</accession>
    <name>A0A1C1CTQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTQ9"/>
    <dbReference type="STRING" id="86049.A0A1C1CTQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09248"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06241"/>
    <dbReference type="OrthoDB" id="9368434at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="141" mass="14995" checksum="26BF33E319E7B4B7" modified="2016-11-02" version="1">MPVVPPVAAEVPSAQQQEDLLGDFLASSAIAIPTYGMGADQAQQGFFDPLSLEMGAWSGDLNLEFPVREVADWLPSGEDIPQEYSFGDNSFEAPYTPFRSTAAVNSPFTAAGHDVYLTSSAEGSSDGDWSFGGLLTGNRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUL0</accession>
    <name>A0A1C1CUL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08200"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05978"/>
    <dbReference type="eggNOG" id="ENOG502T43W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4111371at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="73562" checksum="BF907151E00E72D6" modified="2016-11-02" version="1">MAASITLVYQHSVVDDIAYHRYQQSMSKDKRSSNQPAPFKGEFSFVNKDAGNIDSKDHNAAVSWHVMNRYERWKKQEQAKQLRASANVPVGPLSPPSQQPPRIPTPRQQPQPSRPRGQSVRRVSIDNPNKRARLTSEFQPPTVPPATPFGFDPWMVEQPLQLGYPGIGSAQTAGGSGVQTSAISTPSTQSSIMEDDPTAILNSINRSLDPSASPFDSSAFSMTPLVNSLISFAYEVFIPQSWPKESEKSQNSYEIARSWDDAVLINQDTCYANAYLSLLTAAMGALTEDDTLTYHSRYFQGQAMTELRQRVARPGPQDLITLKAVLKLFSSETLVDNTSVARMHLKMLRNLVNAAGGVILMDAWFREDLLSCDCYFALKYDTRPLFPASEWTPGPLSQPWKARLLSAGIFGEHAASVDPLIEHAVMKAVVTDLRELFKAHEYTQVHDVPGDDQLLRWQQLRKFDCISRLADHDCNLAIYPHLFLRPLTQAYTCAATGLMAAMVLGTPEPVRFGLKLLSDLRQKLVESDSEGAAAEHRRLRLWALYVGSLAEKVHPVSAADQDWFASKYRVHAESMGVSEWEDTKKVVRQFLFSEKLHQEIESGRAHRVMDVRQGLYTSSGCSWREPLLDTNLLLGEPEEDISGARAGSVSVAAGKRRADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUX2</accession>
    <name>A0A1C1CUX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative c6 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_08542</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUX2"/>
    <dbReference type="STRING" id="86049.A0A1C1CUX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08542"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05878"/>
    <dbReference type="eggNOG" id="ENOG502S073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5423818at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT52287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="407" mass="44599" checksum="B49F1B07AB529B99" modified="2016-11-02" version="1">MGEPHGSLDRGGSLVVGSTASSSGDLDLVHDNAVANAQDLALGDGCYPLFDFSIEGSAFNDNFTVDGIFAPGSDALVQDHSLADVGMAAYGKPRARLKDWCDWSRHGLSLDVVTERLPALPDPETGMVTGLWIERSQAQSSADLIVQSLRAFPTMMLRRETFPWFIHPQSQLMSKPGSGATALPDAISTCMGIAQIFTSRTPETKPFLWRIIRAEYRRLLSEMHDMSKFDVLLATQACMIYLVMCIIDHSPDNEEHGQELLRALYVLCIRFKELAGGQGAGNGSQSELSSPSRTWEDWIFAESRRSLWLLVGCVVCVKTGVACDPTGSYRSIPLPGPKSLWEAPTQSAWELEYEASRLLHVKGLVTLGDLVDIQRSPYAPLNSGKLDVWNARIDSLGSLLNLVHTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVI3</accession>
    <name>A0A1C1CVI3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">XRCC4 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVI3"/>
    <dbReference type="STRING" id="86049.A0A1C1CVI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10398"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03874"/>
    <dbReference type="eggNOG" id="ENOG502QWJA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8064436at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053962">
        <property type="entry name" value="XRCC4_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067:SF1">
        <property type="entry name" value="MITOTIC APPARATUS PROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067">
        <property type="entry name" value="YALI0C15378P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21924">
        <property type="entry name" value="XRCC4_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58022">
        <property type="entry name" value="XRCC4, C-terminal oligomerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XRCC4 coiled-coil" evidence="2">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="357" mass="39511" checksum="28C202F885CED5CA" modified="2016-11-02" version="1">MTSSWVVRLLQDNQEETPILINVSRKEGGDELDLDLLATDGTAAFTSKVRRRNLKKLRAKNYDGPDDEWSNTVLSVLGPKTRSTAGSPQQADLDVTCSFSGKGSNRTLSLVFCNKVEDITQRLGTIELPQNTDAEDDVDLFGWTSQAIEQRDRLQDEVTGLRGQVKTKDDIVAGLQKQIDELVEAKAEHEKQMLSKFALLLNEKKLKIRNMQRILSTAKIDQKKLRELQAVVGDEPAGMVRRKKRPVDEEVEHEESEDTDAYETRDADPAPNAQKENESPESGNTTPTASEADDDTDDEDLSRPPAYSSQPRTRAATSTASQKQVNAPSSKKSQKDPEPAPAADDDDEATASEDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVJ8</accession>
    <name>A0A1C1CVJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10712"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03929"/>
    <dbReference type="OrthoDB" id="4766847at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651081" evidence="2">
        <location>
            <begin position="28"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="260" mass="26219" checksum="A1949D2CD4D9A376" modified="2016-11-02" version="1">MKTFTLTLTSTSYLCLAIAATARLAQAQAQSYCDASVGYVLPDSTSDSGTDDTSGYTPDSGDCDAECQLYYSQQQTLYSDYFNDAVTAGGNSFLSAAGGKRKRDHLQHHTRRASNRAAAAAGLSPRQSGGGDGSDGGDLYLTCTAAETCFVYENIPLCIDMATGDFTDPTGGSGNVLTGTYNAAVDTGSSGTTGSDGGDDDDDTDTDSDSDSGSDSTDITSSSSSSSASPNGASSSSSTCAGGITLGAVVFAAVFALLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVR6</accession>
    <name>A0A1C1CVR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-terminal-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CTBP1</name>
        <name evidence="5" type="ORF">CLCR_10266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVR6"/>
    <dbReference type="STRING" id="86049.A0A1C1CVR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10266"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03970"/>
    <dbReference type="eggNOG" id="KOG0067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001221">
        <property type="term" value="F:transcription coregulator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05299">
        <property type="entry name" value="CtBP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043322">
        <property type="entry name" value="CtBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051638">
        <property type="entry name" value="CTBP_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029:SF7">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="74"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="144"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT52578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="370" mass="41115" checksum="073D551A1B14AD3B" modified="2016-11-02" version="1">MAGNAAQAHGTAQGVDNQDIPTYTIIQADGLYPDDILETKIFTENPPHAYKVKYLQTGLFPTGTPLPKPWSTIPQELREQVDGIMVLKMGFTAADVALFPRLKVIVRMGVGYDRLDRVALAKHGVTVCNVPDYGTAEIADHALSLALSLRRGVLLHHDRQRQPYLYPWMVLETPLVSRIQGATFGILGLGRIGTAACLRAKAFGWNVLFYDPYLPNGVDKALGIERTKDIKDLFRRSTMLSLHCACTRETRDMVGWDLLSLMPQGSILVNTSRGEVLQLDAVERALREGILAGAGLDVLPEEPIPEDNVHSLIRAYREREEWLVGRLVLTCHTAFYSPQSFVDIRIKSAQTMREVLIDGLQSNVITPDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWY1</accession>
    <name>A0A1C1CWY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">OXCT1</name>
        <name evidence="5" type="ORF">CLCR_09977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWY1"/>
    <dbReference type="STRING" id="86049.A0A1C1CWY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09977"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04413"/>
    <dbReference type="eggNOG" id="KOG3822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="527" mass="56798" checksum="0CD44EAA370173EE" modified="2016-11-02" version="1">MSFLESPLRTASRSLRTARYFTRDQRKQNLLLARSFSSTLRRHEINKVVGSAAEAIKDMKSDSTLLCGGFGLCGVPDTLINEVAKTPSITGLTAVSNNAGIPGAGLGQLLQTKQVRKMIASYVGENKVLEQQYLTGEIELELTPQGTLAERCAAGGKGIPAFYTPAAFGTVVQTGEIPLRHNKDGSIAAFGKPRDVKVFNGKSYVMEESIAGDYAFVKAYKADKLGNCQFRLAANNFNGAMGRNAKVTIVEAEHIVEVGEIDPVAVHLPGIYVSKVIQATAEKKIEKYTNRKEEGQEDIKAALGGKGDTASKRERIVKRAAKEFQNGMYANLGIGMPMLAPSFVDPSVEVQLQSENGILGLGPYPRKGEEDPDLINAGKETVTLNPGASCFGSEESFGMIRSGRINMSMLGAMQVSAHGDLANWMLPGKVKGFGGAMDLVSNPEKTKVVALMEHTDKKGNPKILKQCEFPLTGRACVSRIITELCVFDVDFTHGLTLIELADGVTVDEIKAKTEAPFKVADEIKSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXC5</accession>
    <name>A0A1C1CXC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative acyl-coenzyme A synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_09925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXC5"/>
    <dbReference type="STRING" id="86049.A0A1C1CXC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09925"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00105"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="39"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="451"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="552" mass="61475" checksum="02D6A7DCE1348A54" modified="2016-11-02" version="1">MIFESEYHVEIPSIDLLSFLFSRTPFQDNDPIWINPSNPANHVTLAKARDLTHRIGQGYRDLGVGAEEAGKDIVLTYVENQVMVAPNTLGVLCAGGVHATCSVTATAFELARQIRLSGPKVLICSPRTRKAAEEAITQSNTDVRLVMMVSDSVDIVDTDDGKSIIGDRKLDWQRFTDPKVLQRTTACLVYSSGTTGVPKGVVTTHANIVANLCQMAFFFDHFAQKAIREGVYLRMPGVMQNAVAVGIYVQTMLALQCGMQVYMFPKYDFSSLMASIKKYQLSACFIVPAIWNRILQECTREDVASIRFAMSGASPLPLPLQLKVHDMLPDGVVLRVNWGMTETVTAASQPNVTEVDREGSSGRLLPNMQAVIMSPSGEKLGYDEPGELCIRGPNIIKEYFDNPEATRAAYTADGWFRTGDVAHFDRNGKLYIVGRSKELLKYKSFQVSPTEVESVLGQLPGIVDVGVIGVPDGQGNDLPRAYVVRSDKPPRLEEKDIHDFLNPRVSHYKRLRGSVRFVDEIPRNLNQKIMRDVLKQWVEREEGRKDNFKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXN9</accession>
    <name>A0A1C1CXN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">panB</name>
        <name evidence="7" type="ORF">CLCR_10486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXN9"/>
    <dbReference type="STRING" id="86049.A0A1C1CXN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10486"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00183"/>
    <dbReference type="eggNOG" id="KOG2949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT53221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="341" mass="36459" checksum="0490A5E198119235" modified="2016-11-02" version="1">MVSSLTRPLLRDLHRAATSRQTRQWQQIRLSSHAPSSAALAARGQKPVTIQTLQTMYAENKPITMLTAHNFPSALMAQEAGMDMILVGDSLAMVSLGMDDTSEVTLDEMIMSARAVSRAVNRSFTVGDLPMGSYELSPEQALASAIRMVKQGRMQSVKLEGGAEMAPAIKKITTAGIPLCAHIGLTPQRQHALGGFRVQGNTLDKAMSLFKDAKAVEEAGAFAVVLECVPPDIAEEVTKALRIPTIGIGAGNRTSGQVLVQIDMLGVRPPDSFMPKFVKQYGSIWDAGLTAIKQFKDEVSDRSYPGPAHVYKSDAKVTEAFKAAVESTAAPASQPIAAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYB5</accession>
    <name>A0A1C1CYB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Checkpoint protein RAD24-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_09585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYB5"/>
    <dbReference type="STRING" id="86049.A0A1C1CYB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09585"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00432"/>
    <dbReference type="eggNOG" id="KOG1970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="9">
        <location>
            <begin position="514"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="844"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT53466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="881" mass="95386" checksum="C223C63261E921CB" modified="2016-11-02" version="1">MAPRPAKRQRRSTIALSDEDDADFGLPSSKQAKGGSQREITRDGRTSTTVSPIKGTRTRPAPKKAAATSSPISSPEKLRKNSKVKDDAVKNKSLHNFFGKASEEQRWRKKSQTPDLEVENGAELSDAIEDDDLSDETLQELGLKIDKSSKPVERRNPGLLPAVGGPKAGPNGGSLPSSQRFIKPAVTARNSTNAPSADRAEVEGHAPWADRYGPSNLEELMVHKKKVADVQSWLQSKIDGRNNQKLLVLKGPAGSGKTMTVSLLAKAMGLQVVSWHNPAVSESGSNNSISAQFDEFLNRGGQFGSLAFDHDVSTGQAPEGAISSQILVIEEFPATMTRSSSALQSFRAVISRFLARAKPAPAMAFRGHQSSEEISPPVVIIISETLLSSSTALADSFTAHRLLGPEILNHSFVTTMDFNPVAATLMTKALDLVVKKEARDSRRRRTPGPAVIARLAEIGDIRSAVNSLEFLCLKGDNGTEWSGTVAAKVKRSSKDNAALTETERNSLALLSQRETTLDMFHATGKIVYNKREDPRVLDTRAEPPPKPPDHLMHLYTPKVSQVDIEALLSETGTDIQTFISTVHENYILSCGGDSFEVSFEGCSDILSVSDVLNPENRPNRRGNASNPNAGIVLSNFQAGSSDTLRQDEISFNVATRGLLFSLPFPVHRSGAAVPGGKRGDEFKMFYPASLRLWKPMEEMHGLLDMFVYGDGIAPSRPATSGADGPISDGGVATWQSRILAEDSISTTVPQPPIKSEPPDQATWYPALMGVGDEQDFLPPPTTHAKDILTLELLPYRTRILSARHQDTTSLEKITKFKPTSYLSTAEDHAEEEDDEAMATALPHATRAGSSTASGRNAAVTHETPSMGVEKMYISDDDIEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYD4</accession>
    <name>A0A1C1CYD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYD4"/>
    <dbReference type="STRING" id="86049.A0A1C1CYD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10419"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00515"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="24"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="367" mass="38408" checksum="19D3D48FB2213E74" modified="2016-11-02" version="1">MATATAAPLPSTMRAWQFTTTHGGLEKNLTLNTAAPLPPHDAHSLGKNKLLVQVLAMSLNPVDYKIAELPLVGRFAIKTPASPGLDFAGRVVAVGEGLQRDSSSSKIAVGALVFGRLDGPTQFGTLAEYTVASRAGVALLPQGVSPRDAACVGTAALTAYQCVVPNIPRVKRQDGSGDTTRVFINGGSGGTGTWGIQIAKAMGCYVATSCSAGNADLCRSLGADEVVDYAATDVVEALTQSAATSGNFDLVVDNVGGDGRLFWQCHRFTNPKATYVQIGAPIGLHTALDMAMKYSWPGFLGGGRRKFKFLGVGNDSGQLEEIGKWMADGKVRPVVADVLPMQDAPKGFEKIKTERTKGKIVVVVSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYE7</accession>
    <name>A0A1C1CYE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_09793</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYE7"/>
    <dbReference type="STRING" id="86049.A0A1C1CYE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09793"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00397"/>
    <dbReference type="eggNOG" id="KOG2641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="538"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT53430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="629" mass="71371" checksum="2F10CFC2BAE869D9" modified="2016-11-02" version="1">MDAMSSGGTGNKLTKVIIILTGVASLVATLISVLSIWLQSKNYRKPLLQRYVIRILLMVPIYSAASWASIISLKAAFYLDPLRDIYEAFTIYTFVQLLINFLGGERSLIIMTHGRPPVSHPWPISLWCPKMDISDPHTFLLIKRGILQYAWLKPILGAATIILKSTNTYKEGYISVDSGYFWTGLLYNVSVTVSLYFLAMFWVCMHNDLKPFRPMPKFLCIKLIIFASYWQGFFLSILQFLGAIPNDVPGYTPDNLAAAIQDALICFEMPIFAISHWYAFSWHDYADVTISAARLPVRYALRDAFGPRDLIEDTKETFRGKHYDYRSFDSGDNVIAHEESHSRVARMMDGMRYERGGKGKYWIAKPQDASSRTPLLGKDAASRAPAPESRGKAHDYRATEPDIEIGIDAEDERLYTNARALEFGDWNYPVITAHEARREDWMRRNPEILTTATNRNLLQPTRDHKNRRRSELQEHIRKGKNRSTSPSEGSSQQGAIEAKLKRQQERSPSASGKSDRSQLVDLVVEDTEAEEAEIVRARKEGSDAWNSGPQRHFVRTYSIDEEAPEGEDIREGYDPSKVPSRPPAPERAVSDDESNILDEGDRGRPLNQNGTERGEGQYASLIEEDNVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYP2</accession>
    <name>A0A1C1CYP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CHY zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_11395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYP2"/>
    <dbReference type="STRING" id="86049.A0A1C1CYP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11395"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00574"/>
    <dbReference type="eggNOG" id="KOG1940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253329at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="6">
        <location>
            <begin position="634"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="723"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT53622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="754" mass="83457" checksum="6F1F5D5B39FB21C7" modified="2016-11-02" version="1">MSINHNLCINNLILHVQSKGKAPSTDQTPGRQQAQDRADSSVGNQPQALPHPARISVSRRSPSQKPVSQLQQANPREFQLGQVLKRFSPARSETQDGTLLTFSLAPSDPDFPFELQGGLRCSLTVPAGYPQHGKPTIRITNAEMARGFQINVENGFDSLVASSPQKTLLALLNDLDRNLEKFLTTERAQTIKIIANADKRFEGSHPLPEPTRHRSPSPVSVALVSPTWTPQQKSDALAKRQADVRQLEARMSRMPNFSKSPDGTAFNVPVQIPKVARLPSSLQSLKEVTLLVPKLYNLEPCTVLLKGVSGPEVEKVQLAFERHARGKRDMTLMAHVNYLTQNMYSMVSETAETAESSESHVQTEQSAIEEPKPEVLLGKEPEPRQEYLEEERPHVKFIPRPPEWDRHDSKDETEGSSYDSDDYSDTDDDEDEGEDEDDDGDDEQGGASLPVPAVSTSTDKGIHLSFPHLELHNIELLTLVSLSLSVKCLRCKTPSDVSKIKASSTGDDAGPVASSTRTESCPKCSTSFTFLYVPNTLHANTIRAGTIEATGCTITDMLPSVFQPTCSSCSTAFPVPPGVVSVRGDTPIQVCRSCHAKMTFTIHEVKFLRVSHTSAALPLRRPRKENLGISAGTPLPSNGTCPHYRHSYRWFRFSCCNRVHACDRCHDAAEAHVNERAERMVCGWCSREQRFRRDDCGLCGRSLTRQRKVGGFWEGGQGTRERRLMSRKEKRKYKRPCAKAGAAAQGTKHVKKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZV1</accession>
    <name>A0A1C1CZV1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tachykinin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZV1"/>
    <dbReference type="STRING" id="86049.A0A1C1CZV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09596"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00935"/>
    <dbReference type="eggNOG" id="ENOG502TDQJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="67832" checksum="B98CDC8B07FB06E7" modified="2016-11-02" version="1">MACNAQAGRFMFVEYSKPVEPAKGQKKRRGGPSEVRAHITKNYHRTLRVKRLESLKQGEVPLSLGGFQRQDSSEGNEDDEFPDPEVIKEASWSTGDANQTISPSAPVSAWTKPSPGTTATTTTTSWLSEAPRRSSTNEDLALRLNTSLGLQTLLGEGRIDPFDVLPAQGMPMFVHQVLDHALVHSWPNTVPVKRSLAPTNPVKSSWLKMAMEHPVAFHAFLYATSFHILCAHQGHEINDSAALLRLSHKVETIKLVNEQLQNPSLVPKRKASGGAAAVAGQAAARYGEEEGKRSPPKSTGMGTGPTDALIMAVTILSIHSQRDESVYAKVHAQSPLARLNHLDIYGSMINDEKHIQGIRLLVGQKGGLDAIECYGMADTMQLPTYPWRKPVKSLVMEGKHVLDHTAIDLDSKLGSGFRYLRHTSTGQQLLDVLDAYSEITVALDHHVRGGPTAPELVDLMEVRNCTQHRLLSGLPNPVDFSNPELCLHHAVRLASLIFSDMVIFPLPPTQGVKPRLALMLRQTLETCHLHRCWELHNQVLLWALTLGTIAASYTAQRSWYIDQLLQETSIMQIDDWSVVESICSRFLWWKPICSEPLEWLWNEMISLIDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D035</accession>
    <name>A0A1C1D035_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_09609</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D035"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09609"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00994"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001031">
        <property type="entry name" value="AGL277Wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF14">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="116"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="603" mass="67366" checksum="9208E31F639F9391" modified="2016-11-02" version="1">MAELKDAIAEQERRPSVLFADESKRKASLAQLTANTTGEVRNPLVGIPREALLQDVENYANENNLNDILPLLKKGALVAQSPHAIEHIPELDEPERQLLREEVTHRWRHPKMLYFTIILNSIAAAVQGWDQTGSNGANLTFPIAFGIPDSGPVCEAQGNCEDNSWLVGFVNSCPYISIAFFAGWISDPMNDWFGRRGTIFIGAIFSVLAPIGSACTQHWGQLVATRILLGIGMGLKEVTVPVFSAENLGSAFIPAVPLVIGIYFCPESPRWLMKKGRHAKAYQALLRLRNSPLQAARDLYYIHAQLIQEDILVEESAVATHGNIITRFIELFTIPRIRRATQASGIVMIAQQMCGINIIAFYSSTVFSQAGASVTGSLLASWGFGLINFIFAWPAVWTIDTFGRRALLLFTFPNMCWTLLAAGFCFWIPESSDAHLGMIAFFIYLFDIFYSPGEGPVPFTYSAEVFPLSHREVGMSWAVATNNFWASVLSLTFPRMLQAMTPQGAFGFYARLNAVAFVMIFLWLPETKQRTLEELDYVFAVPTRTHMHYQIHQVAPYWFKTNVLRRKGLTSPQLYKFDADQYAEARGIPDQEAAREKTATAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D043</accession>
    <name>A0A1C1D043_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_00186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D043"/>
    <dbReference type="STRING" id="86049.A0A1C1D043"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00186"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02571"/>
    <dbReference type="eggNOG" id="ENOG502SKHF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="87"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="366" mass="40199" checksum="7A9585DA4625E604" modified="2016-11-02" version="1">MSVRALEARVWIGKEMANVGTPKAEPGAKHGTGLPSLTIFQSPQSSYLVPMAASQNVDVYVLPTGYLWLPDRWIFSDGKPGLRHLSPDYSFLICHPSGKKVLFDLGMRKDLERNPRVIREDYSVIEPYVPKDAHDLLADGPVHPDQVDIVVLSHLHFDHSGDVERFPRARIMVGPGTRDCIQPGYPTADGSPFDGSVLAHDGFTELKKSDYQKFEPGSVPSGFSFDEGVDLFGDGSLLILDAPGHMPGHQMALARTGEDEWVAMGGDCCHHRNLLDDPTRDISVDVGPNGQPGFHKDPVSARETIRKTQSLHSSESVFVALAHDAQVDGIIPLYPQQLNGWRANGLKSKVRSEALTLAEVQGRYHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0B7</accession>
    <name>A0A1C1D0B7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trihydroxynaphthalene reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">THR1</name>
        <name evidence="5" type="ORF">CLCR_00305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0B7"/>
    <dbReference type="STRING" id="86049.A0A1C1D0B7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00305"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10180"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05362">
        <property type="entry name" value="THN_reductase-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT54253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="281" mass="29960" checksum="1700E98404B0EBDD" modified="2016-11-02" version="1">MSKRNSTRLANGSAPAVDQPVPSYLLTGKVALVTGSGRGMGRETALELARRGADVVVNYANSSKAADELVAEIKALGRDSIAVQANVSDVSQIIDMFAQAKKHFGKLDIVVSNSGVVSFGHLKDVTEEEFDRVFAINTRGQFFVAREAYKNLEVGGRIILMGSITGQAKGVPKHTVYSGSKGAIETFVRCMAIDCGDKKITVNAVAPGGIKTDMYHAVCREYIPNGANLTDDQVDEYAATWSPMNRVGQPIDVARVTAFLASQDGEWINGKILGIDGAACM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0D4</accession>
    <name>A0A1C1D0D4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Manganese transporter SMF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SMF1</name>
        <name evidence="7" type="ORF">CLCR_00260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0D4"/>
    <dbReference type="STRING" id="86049.A0A1C1D0D4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00260"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10207"/>
    <dbReference type="eggNOG" id="KOG1291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00221">
        <property type="entry name" value="NRAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="561" mass="61067" checksum="6C787C89CFDDF58C" modified="2016-11-02" version="1">MNCPSRTDDTEAHPDWNQNPHGLSSDLTTRADLNGIVNLREQRANESSLDNNEQEDIRVMPVDNAESPPSAVKSPTAVKVDPLERAAVQQTRPRRLQSFRSPRAFANKVMVILQKYAKFVGPGFLIAVAYIDPGNYATDVEAGAATKYRHLFIILMSNLFAIFLQSLCIKLGSVTGLNLAENCRKHLPKWLNIVLYLFAESAIIATDIAEVIGSAIALNLLLHIPLIAGCAITLVDVLILLLFYRPNGSMMRLRLFEYFVMCLVLGVMVCFCIQLSYIKDTSAGEVFKGYLPSSAIVKGNGIYLSCGIIGATVMPHSIFLGSGVVQPRLKQFDRQNGHIAMGEESDDEEEKYIPSIYAIRACLKYSVIELATSLFTFALFVNSAILIVSGSSLYPKTEATEADLFGIHRLLSENLSKAAGTVFALALLLSGTSAGIVCTMAGQMVSEGMLHWTLKPWLRRLITRSISIIPSIIIAGAIGKEGLNTALTASQVCLSVILPFVTAPLLWFTCRSHIMTVQTDDVGGGVNMRNGWLVTALATTIWLVLVVMNVALLVLVGLGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0G2</accession>
    <name>A0A1C1D0G2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0G2"/>
    <dbReference type="STRING" id="86049.A0A1C1D0G2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00265"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10160"/>
    <dbReference type="eggNOG" id="ENOG502SNG2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-domain containing protein first zinc finger" evidence="3">
        <location>
            <begin position="273"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-domain containing protein second zinc finger" evidence="2">
        <location>
            <begin position="313"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT54232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="51403" checksum="D96CD06B454DEA65" modified="2016-11-02" version="1">MAGQVPTGNYAVTSSTLGSRRYHGSRPVAPSSGSYPDSDDYFLSTSSGMAYRSIPVSDGSFAGPMLSGLSGFDADFASEFLTEDAFSGDSCSDLTFVPSQYPGQGNSPDHLNTSYMPMDSLYMPTMMPSFNTDVSRLPTPPPEEYLQTCFPSGHIFQDQLCPMDKDFTISESATTCNMEPASPSQRIVRRPRPIRSASERNASVSEYCASSTSPPEVRSPPREDPSNREKARVHPYYNRGPDEDGKYHCPWTHEGNCNHQSTTQSKYVDSHLRPYRCKFTDRPECEDLRFSSNACLLRHEREAHGEHTHGMNPYLCKFPDCERAREGNGFPRRWNQRDHMKRVHQYEEIDAPAKKSPSSQSQSKRRKASSAPTSVPMRRSSSSTVSKAHAMVKASIQPTSYGPISRNQYVAPSAYSSHAQDYNAMRAQSVSMAEVQFSHQTVAVSRTSRVSPSYSGDYIPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0N2</accession>
    <name>A0A1C1D0N2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0N2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00976"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01675"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651233" evidence="2">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="165" mass="18506" checksum="E7F5547AA1CA7E75" modified="2016-11-02" version="1">MLKWFAGLFFLAMTLKPAATADTSRIFRFPQGTDQEAEHEMRQALADAMTLARFVAITTIPCEESFLRYFTPADFLLVQRVFRTIANIPVNQQFDPRNVGQILQTLAVYGPLNPKFNQLSIALGDNPDVGPPDPSTEGYRNTRKRSDGIYAGLMLYDPPRYGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0P1</accession>
    <name>A0A1C1D0P1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chitin synthase A</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Chitin-UDP acetyl-glucosaminyl transferase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Class-V chitin synthase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CLCR_00222</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family. Class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0P1"/>
    <dbReference type="STRING" id="86049.A0A1C1D0P1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00222"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10225"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000010">
        <property type="entry name" value="Chitin synthase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000014">
        <property type="entry name" value="Chitin synthase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="763"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1024"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="17">
        <location>
            <begin position="22"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="795"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="924"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCT54296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1302" mass="143594" checksum="610FC9FCC6A98212" modified="2016-11-02" version="1">MANRYSTYSNNSSHVGAARSAAQQPTQVSTTTLLNSLHTVYASGQTYQLDSCTSISVNTWLTAVNPDAQGRVGGVVDADLASRAWEHARRRAEDGCIILGSLHPSTPSLFQAFLQVVPLPTPEVAYAALTALRPFLSCVAPSNPTTFRHSALAAKYTVTLGGTVTGFTLALSGSGIDVEKGLLRIPSESGFRAFDVFYYLLTSASTPAEREVLGLQPPSKYTLLNRSGSYDPPSYLPTADDAAAAEDFRTALKRIGIKGADFRGLLSCLAGLLKLGETIGLLVDADVLEDTCQDVGALIGLEPDVLAKKCTTDDREVLIASMYEALVDWVLSKANDAIAAELRSGALTPDSSTEAGDEVSLTIIEVPGQALGKAIALRSVFDDTQGINAEMKDDGVEVISAGHSVLNETNTAVAEVEADLGIKGGPLSREREHDRDRREGILQKIGAEAEAGGFLRTLLYPVDGEGLNFGRKGRFDINTTLASSRAWFQLSIHPTDDSPSTLAASPSATSAWSAGPVSRQLRAWRLPEWANHRNRRLDFTADFDVEEFVTRYSRLGCKDGKDGIETFLLERGWTNGEVIIGKERIWMRESAWWEAESMLDMKTIKHDYPESNPFAEPLNPFASGYSANPPHNGSGFFPPMGDNMSVQDSRENLLGAAATERAKSVAPTMARTTHTIGGDYGLGPKGDTQKNDSYWDADLGHYVGGMDPELADPRNVQSAKTSAGRQAWVSLVWALTFWIPSVFLRYIGQMKRPDVRMAWREKLVLVFLIFLLNGVIIFYIIEFGRLLCPNFDKAWNAKEVGFHTGTNDYYASIRGGVYDFTKFYKTQHSDTAIKTTAENMLPLAGMNLDAYFPPPLSRACPGLNVDESVLLQHNDTSAVLFPTALHTSGHRYQPNQQSKLYSWDWYSDDFLPKIKEYYKGDLVVTKASIKSQAENDQRQWVVIDKKIYDLTDYFYTLDVMNNFVTYRFLPDEVTELVQNNAGSDITSLWGTNAAFQNSLNCMNNAFYVGKVDFRDSAKCQVNNYLLLAFTLILCAVILIKFLAALQLGSKRRPAPQDKFVICQVPAYTEGEDHLRKSLDSLTALQYDNKRKLICVICDGMIVGGGNDRPTPKIVLDILGVDPKIDPPALPFRSVGNGSEQLNYGKVYSGLYEYEGNVVPYIVIIKVGKESEQTKSKPGNRGKRDSQILLMQFLNRVHHRSPMSPLELEIFHQINNIIGVDPELYEYLLMVDADTMVKEDSLNRLVAACANDAKIAGICGETSLENEERSLWTMIQVYEYYISHHLAKAFESLFGSVTCLPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D137</accession>
    <name>A0A1C1D137_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D137"/>
    <dbReference type="STRING" id="86049.A0A1C1D137"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00934"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01697"/>
    <dbReference type="eggNOG" id="ENOG502STYZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="87"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="248" mass="27887" checksum="04F44157E656F086" modified="2016-11-02" version="1">MHVRPALVRDLSDLGTVATNAMFDDELTRFLAPHRHEHPACLRIGFLRRAKKRFYDGHVVLAGVSDRHDSWWNGEDKVVGYLSAISSTQKSANERKPGFPSTWNELELQLLRLEELMEWYSFADRSLCRSAWLQFFNTMAGNGPLDDIKQHWEIDHLSVEPAYQGKGFGSMLVKYVQEFAARDNLPVALHASEQGRSLYKKLGFSDVGAVDMGAGQVHEAMAWYPPDAVTASPAAKKLDDNATEKPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1W7</accession>
    <name>A0A1C1D1W7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_02817</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1W7"/>
    <dbReference type="STRING" id="86049.A0A1C1D1W7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02817"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04744"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015186">
        <property type="term" value="F:L-glutamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015188">
        <property type="term" value="F:L-isoleucine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090513">
        <property type="term" value="P:L-histidine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015824">
        <property type="term" value="P:proline transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="601"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="260"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="670" mass="73604" checksum="48E6D9D1FDC23B89" modified="2016-11-02" version="1">MSQRNKQAPSTWDAYERGRASSFGSLESVPENEQQNLLSSSTPAAHHIPPIHGDEEDGGALRRRSSFGKRFDSIRHLGGPNSIDNFARSLQRAAGFREITPVRRNSVTLSESEQEPGPARSSPEQSTTGHNRSLLRQQLRDYRFQDPNESAVHDDRPTEVEEPTEESSLLPMASRQTLKSTTGSIVPGSLLPSALGTSYGSISSRLTAAARQRASILIMEQEEASRRAREEPEEFKEEPPRQIEREVRPDGEVIDRTVGESTVPMTIFNSTNVLIGVGILALPLGIRYSGWVIGLTFLTLAAFGTSYTAKLLAKCLDTNTGSTTYGDIAFLAFDTWGRNFVETLFILELTAANVALIILFADSMNSLIPAVGVTEWKAIVAIGLIPLNFVPFKTLSVSSVIGIFSCLGIVAIVFADGLIKPRAPGSLRDVAKTYAFPEEWRTVPLSLGLFMAPWGGHSVFPAIYKDMRHPQKYGRALKYTYIFTYGLDLSMAVLGYLMFGDKVRDEVTANILRSTAYPHALSVIIVVLIAIIPITKIPLSNRPMTDTVNKKFYLDLRQMDPKARMHSERSWKHRLARGSIAVLANLIQLGISIGFPDFDSIMALMGSALCFTICIILPVSFYLRIFSSEGKEISLMERIIDWGLLVVCGSLAVVGTVFAILPKDKIGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1Z0</accession>
    <name>A0A1C1D1Z0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_03065</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1Z0"/>
    <dbReference type="STRING" id="86049.A0A1C1D1Z0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03065"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00014"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="35"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT54705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="260" mass="29549" checksum="6F66CEB576B62F47" modified="2016-11-02" version="1">MANVKTKPAGVLPASWYSTRAIYELERRAIFAKHWLLITHELRLPAAGAYAKFTVAGYPFFIIRDKQGELNAFLNVCRHRAFPVVLQDEGVANILACKYHGWSYALNGKLAKAPRFDAVDGFDKSDYGLFQIHLRVDQRGFIWVNLDAAPEPEVKWEEFFDSVDTQGRLQAFDMKNYRYDHSWDMDGEYNWKTLIDNYNECYHCSVAHPGIAKVTNLESYDVKTTNGFIEHYAESKGDPADAAGNVAPTFVFPNASITMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2G7</accession>
    <name>A0A1C1D2G7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_02883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2G7"/>
    <dbReference type="STRING" id="86049.A0A1C1D2G7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02883"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05069"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="557" mass="61925" checksum="2D082151DC31FF59" modified="2016-11-02" version="1">MMTTERERRRQRRRRLKSQISANIFVHAGSTRRHNQRTDSDSSESENVRRRISRSTSPAETDGEVEVCEAEAEAESKSKSKSKARLKLKLKRKLVFFITGNPGLVAYYHAFLSLVVRDLEQMGRTDDVVVVLVGMSLGGFDVQGTTHKTHGTSDSDSESDGKGKRTGMKKRGSASAASSYSESESESGSGPDHASHVNIHDSEEQRLLYPPTFKRGNARLFTLRDQVELSYARVEDLVDRMRMQREQDQDGEPGGMQQNQDGDPVEVVLMGHSVGAYICLELVRLWHERHQRDGMPLPHTAGQDLRTTSIAPAKPMLSSRSAPPWSPSACILLTPTIQDIHLSPSGLIATPLLTNLPFLPYLAQILVHSVLLRLVPASWFASLVSRLTGMQPGSHGLEATLAFLRSERGVEQALHMASWEMKEIRQNRWGKEVWGASHGVTPVVAAEEGLCSSPKLFFWFTKDDHWVAETTRKAIIGSQAPGTVVRRRHVAGSAETVEADEMAVQVNGTKETSRAKESPTIRVLESEGLLHAWCLDQSEIVAKGVRQWLEELWTDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2K3</accession>
    <name>A0A1C1D2K3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2K3"/>
    <dbReference type="STRING" id="86049.A0A1C1D2K3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02832"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05053"/>
    <dbReference type="eggNOG" id="ENOG502S6QE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2351940at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="619" mass="70279" checksum="3577BD58C5344536" modified="2016-11-02" version="1">MVRPQLPPLTHESCNVARPEILKTNCGQSDQSDRPAWSDISARLQNLRNLLSSERHLGAEQQRAFEALDREMGDQMAEVGAVDHEPGHQAVGDRSAIRERRRRDLEAHLQEQDAPAVSGSLPQTSSPSSLMRSRRRAFRPSERLQRYQRERLAQSGRGTASESRVSPPHLSPSWQEQSISDRGDRPRAKRRKLDDGTYEEEPRTFSYGDKGQVVPGELKLDIISCDGGEYSDPHTPINSYPQNVLQDDTTVYCTKSNRCNLLLKHIGGMPFTLTKIVVKAPRSGYDAPIQEGLVFIAMEDDALLERTSQYDMRWSAPHYRHERRRGDRYRPSHDYMNSARSPLRSIDRSRYLSSPTYPEDDPFLETHLVPGFQVTVADPSDEDEAADGPPSPRPWHDDEYSLRSYVDRYRPVYLGDEGNNGRPWTNSSDSEGSERDIPRETRGPSERERFHRQQRDLENTLAHRNRMLDLMRAQQIRESDEFFGRHDRDHDQELSYLRRPAFGRTGSRAAAIAIGALDPVRSPDDQSNTTTPFETPASKTIPNRAESSSSAKGDVIVPHARFFISRSKSSTAIKFDPPVSGRYILVKLWAQCPNANIDIQAILAHGYGGPRFFPALEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2T6</accession>
    <name>A0A1C1D2T6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative vacuolar amino acid transporter YPQ3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RTC2</name>
        <name evidence="12" type="ORF">CLCR_02964</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2T6"/>
    <dbReference type="STRING" id="86049.A0A1C1D2T6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02964"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05186"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000011">
        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF35">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT55097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="439" mass="48424" checksum="55DCD5606EE6E3F3" modified="2016-11-02" version="1">MCQGCRDFLLTTDVIPFTFVVFAPFATLVLSSRRLLAPQIEFAVPSNSYELLEAPFLLISKLDRTDLDLTGVERTLHFCIVRASSRLHVFTSSVMFPPQQGTSLDIEALSGICGSISIACWVVVFSPQIIENFRRGSAEGLSVVFLVVWLAGDVFNILGAILQGVLPTMIILAIYYTLADIVLLAQVFYYRGFTLTDQVKPKPHPDGDAETRPLLQSDSPTQPLTGAESTSISQWQRHLSVDGAHLSPATPLIDPPKATDLPAISSNARPTSTLQTALWNAFAILLVCAAGVFGWWIGEQRTRHHVKQDEPEPLEFDLLGQVFGYLCAVLYLGSRVPQLLLNYKRKSTEGVSLLFFLFACIGNLTYDMSIFAYSPVCHKPGHCAPGEAKTLYLRYIAVNASWIAGSLGTLLLDMAIFVQFFLYTKDEEEDSEVAVVDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C628</accession>
    <name>A0A1C1C628_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">ATP synthase subunit 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ATP9</name>
        <name evidence="17" type="ORF">CLCR_11478</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="17"/>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion membrane</location>
            <topology evidence="2 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000023">
        <property type="protein sequence ID" value="OCT43975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C628"/>
    <dbReference type="STRING" id="86049.A0A1C1C628"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11478"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000009">
        <property type="entry name" value="ATP synthase subunit 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF0">
        <property type="entry name" value="ATPASE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0138">CF(0)</keyword>
    <keyword evidence="9 15" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 15 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="16">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT43975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="74" mass="7507" checksum="DB8FCE0F76E9E3B7" modified="2016-11-02" version="1">MIQAAKIIGTGLATTGLIGAGVGIGVVFGALIIGVSRNPSLRGQLFSYAILGFAFAEATGLFALMMAFLLLYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C714</accession>
    <name>A0A1C1C714_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MAE1</name>
        <name evidence="14" type="ORF">CLCR_00603</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:12653"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>oxaloacetate + H(+) = pyruvate + CO2</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="1.1.1.38"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C714"/>
    <dbReference type="STRING" id="86049.A0A1C1C714"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00603"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01182"/>
    <dbReference type="eggNOG" id="KOG1257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000001">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000055">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="13">
        <location>
            <begin position="89"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="12">
        <location>
            <begin position="284"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT44261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="586" mass="65137" checksum="6D87F08EF2543861" modified="2016-11-02" version="1">MTHGKKKFEHLPLAQKGPLEVPFSGRLLLDNPFYNKGTCFTSQERVDFHLKGLLPTNIQTLDEQVDRAYQQYSAQPNDLAKNTFMTSMAEQNSVLYYRLIQDHLREMFSIIYTPTEGDAIQNYSRIFRRPDGCFLSIKHPEEVEERLSKFVREGQPDGGVDYIVVSDGEQILGIGDQGIGGILISVAKLALMTICAGLHPDRTLPVVLDTGTNNEELLNDELYLGHRFARVRGQSYDDFVDKFMRTAKKLYPNAYIHFEDFGLTNARRLLDRYQTEYTVFNDDIQGTGCVTLAAIMAGLHINQVKMTDLRVVLFGAGTAGCGIAEQVQTAIATESKKSKEEVANQIWCVDKPGLLLDNMNDTLSVAQKPYARKASEWEGKDTKSLQSIVAEVKPHVLIGTSTKPGSFTKEVVQEMAKHVDRPIILPLSNPTKLHEAKPEDLIHWTDGRALVATGSPFPPVKYNGKEIEVAECNNSVCFPGIGLGGVLCKAKLMTDKMLVAAVSALAREAPAMNDPGKALVPDVEHARSVSVKIAMAVIRCAEEQGLAQTRDIPQSDDELQEWVEAQMWDPVYRPYVKAKNALHASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C790</accession>
    <name>A0A1C1C790_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C790"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06459"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="97" mass="11528" checksum="CB4294A69675BC77" modified="2016-11-02" version="1">MTPIPIPILIPIPIWIQFIWIQFIWIQFIWIQFIWTQYTLRLPRSFDPMNPFDEQTNTRTTETTEQGDKRTIKPSRYVKGETIRISLAIANFSISGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7L4</accession>
    <name>A0A1C1C7L4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_05843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7L4"/>
    <dbReference type="STRING" id="86049.A0A1C1C7L4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05843"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07149"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08284">
        <property type="entry name" value="FDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="25"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="197"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="364" mass="39483" checksum="6F30F79EC2AA71DF" modified="2016-11-02" version="1">MRAVVFKGPYDVVVEDRPAPKIQDPGDIIVKVEYAGLCGTSEIDGIETSIAKTGASELHMYRGHQKTAPGFILGHEFTGTVVELGADVRGFKKGDKITCPFSLTCGECFYCQRELSSRCVKAALTGTVALDGAQAEYIRIPLADSTAVLAPPQIDSKALIMMADIFPTGYFAASNAFRLLTELERPDTTVVVVGCGPVGLCALVSATKWKPKNIIAVDSVPSRLEQARALGAEPWNFQTDLQGLKARVAELTDGRGADVALELVGLSPALRLAFDLIRPWGVLSSVGVHNGEVPWTANEAYHKNLRLQTGRCPVRAVFLEALDLLKDKQDQLGFMTDHIVGIEHAVEAYKQFNEAKVQKVIFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C869</accession>
    <name>A0A1C1C869_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myo-inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_05525</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C869"/>
    <dbReference type="STRING" id="86049.A0A1C1C869"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05525"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07332"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="125"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT44661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="650" mass="72600" checksum="AB07CD23BDF98668" modified="2016-11-02" version="1">MSDAKDIRYSTTGQTNGQQADHYEKGPSQERRRSSIVDLNRDKNLDAKISNPLADIPREDLYADVEDFANRHGLTAELELLQKGALVAQNPSQFENLSVLDETEKDCLRIEVNRKWKHPMKLYMTVVVCSIGAAVQGWDQTGTNGANLSFPEAFGLNTPEGQPGYERDFWIIGLVNSAPYIGSAFLGCWLSDPMNFYFGRRGTIFTSAIFLIATPIGGAFAQNWEQLLATRVLMGIGMGLKGATTPVFAAENSPAAIRGALVMTWQFWTAFGIFLGTAFNLAVWNAGDIGWRLQLGSAFIPAVPLAILVYLCPESPRWYIKHGKVAKAYQSLLRLRNHPLLAARDLYYISTQIQIEHEIVGNSTYITRFTQLFTMPRVRRATLASFVVMIAQQMCGINIMAFYSSTIFRQGGASDFIALLGSFGFGAVNFIFAIPAFLTIDTFGRRSLLLFTFPNMAWTLLAAGFAFYIPRSSSAHLGVIALFVYLFAAFYSPGEGPVPFTYSAEVFPLSHREVGMGWAVATCLFWAAVLGLTFPKILEAFTPTGAFGFFAGLNVLALIMIFFWVPETKQRTLEELDYIFAVPTHRFMSYQTGTWLPWFIKRYIFWNKSAELKPLYTFENGVMMDIKDQKRHAERERAASLSQEAAKSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C895</accession>
    <name>A0A1C1C895_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C895"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06303"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07350"/>
    <dbReference type="eggNOG" id="ENOG502SJKY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2446447at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF3">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="63"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="214" mass="22970" checksum="8D48EB49444E0B32" modified="2016-11-02" version="1">MVEVKKYHLPPTALIPNSPRPLLHYPGILSASESITTEAYDSFTNNGWQVQWIFRYGQTQASHYHSATHECMAVLSGTATIRFGVADTASDLEESTHGSGQEGGGVEVEARAGDVFIIPAGVAHKTFDTQPSAELKLLTPGSGHDIPASDVRGALQKLELSGFTMLGAYPVGGQWDFATGGENAGNYTQVWEVSRPENDPVLGKDKNGLVGQWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8Q5</accession>
    <name>A0A1C1C8Q5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8Q5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06322"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07613"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF6">
        <property type="entry name" value="ISOCHORISMATASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="204" mass="22257" checksum="3659C68EB21BC711" modified="2016-11-02" version="1">MAPPKTALLVVDMQVFFESMATAALPNIIKLCDHFVKTSAPIVFTKHGHPQSEMVAHSTSQLVRRWGVKGSIGEGSAAGEIVSELQRFLPKANKTPTIGELLPGPESPEFPKLLPKNTYDGFINTPLSSLLENAKVERVIVCGVMTDCCCDTTARSSFNRGYETWLVSDACGSANKTQHEAGLEGLRVRVWRGDEDKRGDIDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C959</accession>
    <name>A0A1C1C959_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="5">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_06126</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C959"/>
    <dbReference type="STRING" id="86049.A0A1C1C959"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06126"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07746"/>
    <dbReference type="eggNOG" id="KOG4133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000008">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="9">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="8">
        <location>
            <begin position="225"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT45073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="315" mass="34482" checksum="5CCC53EABC432E48" modified="2016-11-02" version="1">MNASSDLSFDFSPDLPVAISLVGGRYLVFDVKIVTWLRREHRICGTALGTLPIAPSQNLFLGVPIEIMPEEAKLLVERNIAVIADDARAHAQAVRSGDQARRADYLARIEKQSNQVKQAKDQEKMESRRRGLEKQSKKSAHSSRSTQVDPANDLLDFDEAVTPHGGAEEFQAADEEVVVQDVSPVKVLPLTATSSSYRVTPATSRLLLPPPLSAAQSTIEDLPPSYPLYRHLHDKGFFMTPGLRFGCQYTVYPGDPLRFHSHFLAIGTEWDEEIDLMDIVGGGRLGTGVKKGFLLGGANPTGGGVRTFSVEWAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9J8</accession>
    <name>A0A1C1C9J8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9J8"/>
    <dbReference type="STRING" id="86049.A0A1C1C9J8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06093"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07861"/>
    <dbReference type="eggNOG" id="ENOG502QRAQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="37"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="1">
        <location>
            <begin position="203"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="307" mass="34428" checksum="244AD5969F1036FA" modified="2016-11-02" version="1">MGGEGSEDQDQDTRSVGALSIPAGLEALCVTRFDQLTTTGQLIYEPSTAETVEDQGFMVNFRFAPHLRRKPITPADAPERTTGKGHNPFLNPPPSEVLSPIGPYHLLLVNKFSVYRPSLLLITREFSPQADGLSRNDLAAAWTILCHFKEPYMMIYNCGFESGSSQGHKHMQLWPYPNEQELGFKLFPSQAKSDVYVTEQISNVPHKHFVLRLPTNADLDTLVRTYDKLLRCVRQSHCEAGKGNDYNVIVVKEWMCMIPRRHSGLDRGAGANSAAMLGLVWIVTEAEREVWNSTGPTEYFKYLGLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9W7</accession>
    <name>A0A1C1C9W7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9W7"/>
    <dbReference type="STRING" id="86049.A0A1C1C9W7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06402"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07886"/>
    <dbReference type="OrthoDB" id="10522324at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="146" mass="15324" checksum="6C2839E55B26F712" modified="2016-11-02" version="1">MRPVPASAGSALRNWTRHTLPSSSSPASQSPRVASITASNAPQRRSAASGAEAPGASSFDSPFGRSKDQHYDTRKIPSFKGYASNSPEISNRVFQYFMAGSMGLLAAAGAKNTVQGTKEKTHLKPSPAQPGSAKSLSIQSDSRDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB27</accession>
    <name>A0A1C1CB27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB27"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01709"/>
    <dbReference type="OrthoDB" id="5580261at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018811">
        <property type="entry name" value="MRX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002:SF1">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="220" mass="25265" checksum="3F68128A7957692C" modified="2016-11-02" version="1">MRRSLVRAVRPPNTAHGARRWRSNTKLEPPYQAPKPEEQTAARSRFDRFVDRTPRFLRPTVTGLRQAPFSHVAAFFLLHELTAVIPLFGLAGAFHYWHWLPPYFAEGAWIAAGVEKFGRYFRKKGWITEKQETLVENETRDGNAAHIENQNTASKWFDRGEAATRWVVELATAYAIVKLFLPVRIFVSVWGAPWFARVAVIPARNATRTVVAWTKRPSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB59</accession>
    <name>A0A1C1CB59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB59"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01494"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03590"/>
    <dbReference type="eggNOG" id="ENOG502S38H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3035230at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="599" mass="67890" checksum="B4ED76FD7818E113" modified="2016-11-02" version="1">MVDVNADDWVDVKAESRDSEQKPEPPHLADEKKEYAFYVVTAESALARLNKDASPIFPVDISQDTLWSTWLDNLDPSLRHEYACTTCRRFIKRYGGLAQVDSQGAVQPLVWDPTERPGPDHFRASIKAIYDKVFSATVSEEFKVIRRTKSVGTRTSGGYNHFYLDFPEARIRKKEAPGFESAPVTVLATMLGRVIDDYSLKTIRQAFTILTEDKLPHADSHKAAIRWFLPLRENKRMEKDSDKTTRQNLLYLHAATSFRGCVSQLRSGALSTLLQDIEAGKDFDEIKEHWSEVNDPARYLRPQAAPKAGQLLAAELLMESLGITSHDLRRRDFTMSELPKQVIMFMSAARKKRVSTAAKPGGIFSTVKPKPRNPPPKLAPPDKTGLSTPPTRISFTKFVTDILPKAVKIEYMLERRDPITFLITGYEGTKPLMQWHNDENRNRVSWFLYICPPPVTEHNLLPDDWNEVACILPAPHLWDGIPLTTTFPLAPADSTDFKYYHKKEGFRYMLCLEGVRLDTKATSCLFPSFLKSEFHGARSAIEAYSTSHPLEKVPNIEEKGGIVAGVIVSRSQDMDECKHLLRVTDEKGDINTYRIALFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBX8</accession>
    <name>A0A1C1CBX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General amino acid permease AGP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">AGP2</name>
        <name evidence="8" type="ORF">CLCR_00402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBX8"/>
    <dbReference type="STRING" id="86049.A0A1C1CBX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00402"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10047"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF6">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="44"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="574" mass="63306" checksum="221723A579EF6636" modified="2016-11-02" version="1">MDAYPGSKEKNGGVAQRPGSHDVQEGFISDNADHLQRHLNNRQIQLIAIGGSIGTALFVSIGTGLYNGGAGNLFLAFAIQSMVLAMVNNSVAEMSTAYPVSGGFIRLAGKWVDDALGFMCGWNFFFYEALLIPFEISAFTLVLSFWSDRVTEPGPIAGVCAGVILAYAAINILAVRAYGEAEFWLSGGKVVLIFSLFFFTFITMVGGNPKHDAYGFRYWTDGQAFREKIDTGDLGRLQGFLAALSSALFTVVGPEYISIVAAEAVRPRIYIKAAFKMVYLRFGIFFIGGALAVGIVCSSRDPALENVVLGGSNGSAGASPYVIAMENLGVTVFPHIVNALMLTSIFSAGNTYTYAAVRTLYGLALEGRAPRFLTYCNRAGVPVYSFCVVMIFPLLSFLQCSSSSSIVITWFVNLVTAGGLIDYIVMCITYIFFYRACKAQGLDRRTLPYYGYFQPFCAWFALIWLFVVTCIYGYTVYLPWDVSNFFSSYSMQLFIPPLYIIWKLVKRTKVVRPLEADLVWEKPTIDAYEETFLDPPVGFWTEMMQLVGFRRIKGGNDKRRPSIALPVEQADGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC23</accession>
    <name>A0A1C1CC23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatidylinositol glycan anchor biosynthesis class U protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PIGU</name>
        <name evidence="10" type="ORF">CLCR_00469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC23"/>
    <dbReference type="STRING" id="86049.A0A1C1CC23"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00469"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10348"/>
    <dbReference type="eggNOG" id="KOG2552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT46074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="417" mass="45891" checksum="F40438AA826891CE" modified="2016-11-02" version="1">MSISLDRKTVAIYAGAALLRLLVFVAFPGITDFLTTRVEISTPISSFRRLQEGLFLYQHGLSPYDGGVFHQAPLLLVIFDMVPSTIVFTGLDILNAISLHSIAENVQLPSPRFQKLDGSLIAAAYLFNPFTILSCLGRSTSLFTNAAIIQSVLHASSGDAIRAMLGLAIGTYLSMYPALLLPPTLLLVHNQKSASTPFATSILSYVGGLAALLATVPVLTHGFWDFLASCYGAQITVPDLTPNVGLWWYFFIEIFDSFRDFFIGVFWLHLVGYVGGMTLRLQNQPLFVITSLLGLFAIFKPYPSIADVSLYLGFLPLYQHVLPCKTIPPSLVQTLTGPVTRYTFIAASVLLYSTLLGPAFHHLWIYAGSGNANFFYAITLVWSLGLTILVGDTLFAVMRDEWEIERPEMKGKSVRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC54</accession>
    <name>A0A1C1CC54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Guanyl-nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_01034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC54"/>
    <dbReference type="STRING" id="86049.A0A1C1CC54"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01034"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09402"/>
    <dbReference type="eggNOG" id="KOG0929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF405">
        <property type="entry name" value="ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="3">
        <location>
            <begin position="465"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="776"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1315"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1335"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1371"/>
            <end position="1382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1399" mass="153798" checksum="9576A235C71EF23B" modified="2016-11-02" version="1">MPLRTLLPSAPGLGLSHRRHSSIVEDAPAPSTSNAPLSRTRTPSNSLKRLSLSLSRTSDEPFPPLLTAGPEEPPRQRPSTQPGAAPEHVRLLNGTGKPAASLDEEDREEQRNAVEDDRGDLPLSAPQRLSQLGMRHASDPQLSTRFRNEEHNAQGAVAPPQIITTAPTTNEADESTQRPSKRKLFARAPSPFRKSQSFKRTILDPFKGASAGEAADGDATSSKSELPRSTTSFERLPRLKTGHRAMAPPAYGDDSSSSLAIPVTRFSESSRSDDSSGDHHVYAKTTTTHTISTTTTFFKLKRRKKDKGPLFPLPEKFARQASGRTTTSHTPAESTAGRKSMSPSRRSNTAVRFDTEPSRHDSASASPTQSAVALTNAPFGSPGATIVRQNSNWSTYSGNSTPSVSLAPPRVSGRGRSSTLSSLGKSNERLSDPSAQSGSARTSTSTSGRRSFGDLLTLPHRLRQNSAPAKGTGSGSSPGTPGSKSNSLHLPREPDTERVYPKREDGDTPASYLERLEAAVPRSGMASILCKSADDFSRTCLRKYMRGFSYFGDSIDIAIRKMLMEVELPKETQQIDRLLNGFADRYYECNPGIFASTDDAQFVAFSILLLHSDAHNKNNKRKMQKQDYVKNTQHGSVQIASDILECFYDNVCYTPFIHFEDEIAVNSHRLSVPKAKRSLIKTKSLESLRGPVDPYTLILDNKLDVLRPSLKDVMDTHDCYCSTGTSSAFDTNALHRAFLHSAVLQIISARSRPDAFQSQASISNPGDTQAGIVSIKIAKVGLLWRKDPKKRKAKSPWQEWGALLTDSKLYFFKDVGWVKKLMSQSESHARSALQSAPLTFKPPLSSFDPDALMSMDDAVALLDSSYKKHKNAFVFIKHGGFEEVFLANSESEMNDWIGKLNYAATFRTAGVRMRGLLGANYEGRHLLRKDSDFSTKSGDTPQKDKRFDAQLAWEIMFYRRQLINEKISDFDERIAVAQKELDNLLRNARHLLILLPIQQKTREALVLAAGRMSAKLKWTRVELWRTRTHRDILAKDLEEEGATAFPVPKGSSLSTPQKTTPLKTGPQELGRTVTDTSHVTLSPVSATSSRPSNIADKIKTPESASIPTDHSMLDLPSAVSPSLSVDPALSRHESIQESHTLSHQVSTASSRHSRDRDRLGRTTDDPEDRILREAGLTNVEGSVTKDRRPDTSESERDRVGAIAGAISGAIDPSKSGSIRRSLQRSLREPHHHSSPSIHRHKRGKESGSSIAATEDGGKSMHSEAEELRRGVGSFILHGKKASVITMSPEWQHMSNEERLKLRKAENDNENEEAVDERKPAQSRAEEGPQGATANGEDDEEEEIEHFDSPRSSRKHSFATTSGEQFVDAETGETSSNRSSSDGNAEAYEKAMGSPRKHYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDA9</accession>
    <name>A0A1C1CDA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02167"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="116" mass="12513" checksum="11FAC3886F45120A" modified="2016-11-02" version="1">MLPDSEIDWLSKHMLGDIPATDIAFVDTSGTQRSLYAEETRKPPLLLPRRPSAAAAAAVAARTVPRDIRNTGPGTGSRGHGDLGSSSSSSIRPDRCSATDPFEPIEHDLFEKQHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDJ8</accession>
    <name>A0A1C1CDJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_01841</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and mocs2a. Its N-terminus first activates urm1 and mocs2a as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and mocs2a to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards urm1 and mocs2a. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDJ8"/>
    <dbReference type="STRING" id="86049.A0A1C1CDJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01841"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01255"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="452"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="518"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="780" mass="82683" checksum="50DE376263AA57A5" modified="2016-11-02" version="1">MSATDDVVGIPAPAQPRVKEDSSPTVPTVTVTEQPDERSSSRVTEQQQDESSPTTPLLIPAPPLAYSRYNRQLLLPQLRLRGQEYLLSSKVLIVGLGGLGSPAALYLAGAGVGTLGFMDSDSVEVSNLHRQIVHTEDAARAGLSKVRSAAARCTALNSEISYVCHDEQATGANILATVAQYDLVLDCTDNPATRYLISDACVMLGKVLISGAAQRGEGTLIVLNSPPPPPAPPASAGAGAVAGAGTALTSTTQDKGPCYRCVFPRPPAPETVRSCSEIGILGPVVGTIGTLMAGEAIKVISTGGHLLQLTPTAQGRSGITTSGAAAAAAAAAESRTKKHTMLLYNTWATDPRSVFRTITLRGRRKDCLACGDDETLAQKNLTRITPEMISQGRMDYGAFCGVADDNVRLLGEENRIDASEFLEEHVRRRHRGHGHHGGTTDDERTRTRVTRRKRKAIVVDVREESEFELGPKVSGSVNIPLSRILRHGDAAFDQLGLDFGTSTGASRPGEMVDQEWKRRLPTTEQEIVKGSESEADPQGGQINKESHIRITEGANVNSPSAGHGETDRVDLAPEAKSSATGPDGGMVSRETHIQAVRGKDEDSCRGSQDRPDGGMLNRETHIPLAAAARIASSTNSAGAGPDGGMVDDDAHIPIPGPVARQPTFSSATFPSRPGEIVKGANENVGYSIYPGDDDNNNHDDDEPPDVYFVCQRGNDSQIAAQKLMTSIQTFQDVTGTETATATATATVAAEPKARRQKVPWIGDIKGGFLALERHATYQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDP8</accession>
    <name>A0A1C1CDP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02155"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01379"/>
    <dbReference type="eggNOG" id="ENOG502SCNK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF3">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G03960)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="138" mass="15010" checksum="C4C672AF0EEA2874" modified="2016-11-02" version="1">MFQQTLYTPFAIRAQINFRRPALESDSILPWEICNLLSLGSGIDGKSGRAHGGFNALVLDQITGMTASVISGTFAPATATMTVDYKAPINTPGVVLCRCWAVERQGRKTWLKGRIEDGEGNLLASARALFIDPKQARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDT7</accession>
    <name>A0A1C1CDT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">apl5</name>
        <name evidence="11" type="ORF">CLCR_01809</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDT7"/>
    <dbReference type="STRING" id="86049.A0A1C1CDT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01809"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01407"/>
    <dbReference type="eggNOG" id="KOG1059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264595at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="10">
        <location>
            <begin position="21"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="808"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="995"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="915"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="841"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="877"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1002"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1030"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT46683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1042" mass="115080" checksum="ABD4B173D33E4853" modified="2016-11-02" version="1">MFEKSLVDLIRGLRGHKGNEADYIQGALKECRSEIRSQDLDLKATALLKLIYLEMFGYDMTWAAFNVLEVMASPKPVQKRVGYLAAVQSFRPEMEVLMLAENLLKKDLSSPSIPVLSLPLVTLPHIVTSSLALSILTELLPRLSHSQPAVRKKTIVTLYRLALVYPETLRVAWPKIKERLLDEQEDSSVTAATVNVVCELGWRRPQDFLPLAPRLFDLLLAQKNNWMGIKIIKLFAVLTPLEPRLVKKLVRPLTKLIQETTAMSLLYECISGIIQGGILDGAESGVDVEEVADLCISKLRGMIVLDGDPNLKYVALLAFNKIVASHPALVAMQQDVIMGCLDDPDISIKMQALELVSGMVNSDNIQAVVNRLMKQLAGSATATGSANGHAEEEQTDMEQRLVPDKRGSENIPLPDEYRHEIISRILDMCSHNTYANITDFEWYIEILVHLVRHLPAHQDSASTRSPLNDETSVGARVGGQLRDIAVRVKELRPETTKAAETLVLLSNRTIAYPKHGTGQGPVIKSAAWICGEFAMYLTNPYEVLNSLIHESSTNFVWSTLAIVVQAIPKIIAQIATAAGQEWNLSRGSTMSLLLARTTEFLEKLSSHPNLEVQERSVEFLELLRLASEALSAQAGDSSQAPLLLTSAIPNLFANMDLNPVAAAAQRKVPPPEDLDLDEPINPDLSSILQASQIADDEDDDDDAFYSFYHEREPVQAITSLQPQTAASYIDTAAAEKEPLSYQSAPESPATKARRRAERMARNKDDPFYIAPPDDADSHFHDVISKSNAGDELDVDSIPIIDLQIDHSQTTAAIPGAEMEDRKPRKKKPVRRFVVAADETLDTSTPTSRSFSNTPTLSVLNQTQRPRSLSPSTHLRDQTQSQSRSTSRPTRSLLTVDSSTLENLSLEAGGTADTESEILRREAEELEMQMALREVEKKRLEMQREQERQRTVMGEGVDMEGTVVKRKKKRTKAKAEVEAGVEAEVEAGVEAEVEAGVEAEVGNEERAGGDEEAVKKKKKKKKKKRSVQPVEELPGPEAGEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE57</accession>
    <name>A0A1C1CE57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE57"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02108"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="220" mass="23497" checksum="83482930887BAC1F" modified="2016-11-02" version="1">MQGRGCSLRNDHDRSSSSRRAVDPDSVFEAPVHGPVPQAEVLPSCSATSHSTALTQDHVEISDSTSNRRPRKRSVAEPRNAVFSPKDRRTYAVASPSAYQHYLLPKLDSSVKVKPTVNQGSAGSDKSLLTLCSNAFYDGGLLYNALLAPPKTCLGASAKSTMISIETANNLATSSILSFIVASIVVLLICLVVLTFDLVINRGARDGFAETKKIYSACAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEJ0</accession>
    <name>A0A1C1CEJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">atg11</name>
        <name evidence="12" type="ORF">CLCR_02224</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="7">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEJ0"/>
    <dbReference type="STRING" id="86049.A0A1C1CEJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02224"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02459"/>
    <dbReference type="eggNOG" id="ENOG502QVZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903599">
        <property type="term" value="P:positive regulation of autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="10">
        <location>
            <begin position="128"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="11">
        <location>
            <begin position="1125"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="597"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="759"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1324"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="861"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1122"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="759"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1338"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1369"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1406"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1432"/>
            <end position="1443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT46960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1458" mass="162857" checksum="A3633718B00DE9DB" modified="2016-11-02" version="1">MSPPSGVSRSISSHDWAAQTPSRSRGGGEGEVMALQVYISHSGNVLTYNDANARVDTLRSWIEANAAIPASRQILMTGRGKIVKNLSNEQEVFVYDKQFLSSDSKPPSRNNVELQPLSDYPLSLADETSLTAWQDLFMQRRAWAVEALEVAKAGVENIEICADEASVIARSMKVALENLRNHVTTLQQRFEETTQWAQGYIQEHRDVLKDWQTSADTLAELPVREDVAKVLRRPTEQDHSGASAPVGTLSDLIDRNALQAAADSVERSSADFEKRLQELLAGMEKLKHDTDAAQGRSTQVPDYDTNALLEETETLAKRIASDYEDVSQMQDNQKSVVAVSRKAATHTRELLPALQGVVGETIQTSLSASDARNAASLDWYSTLQTISSIQSRLAELQSAITNLDFQDNDNFAALGRVFQLPLVYGATLVEATRRSEWTEKMRTEVDALHEDLSQQTEEEQRRRKKWTASHSDFLSEDMNAKDALIDLKATAPRNSWPFVSRDEIFAWVDDLRALGIDDAVQSIMQRMKDLDAPVRKQKLNPFKNGSIQDLSQSAAFRNGDEVRSLQDEKTRLEEKLRASDSRVRKLEDLLHRQSQLSRPASGVFHPGSAADFERQQAPSPSTMQRQSDLSRRSSVSLRRLSNNQDERSLVQKIVALEAQVQKLQEEAHAERRSSTESRDKMQEAELVKRDLMANFEAQKQEFEEERQLLDDEVHRLKVKLEEAEEELDRLNDSRDHFHKEQDQALINLRNELEQAKKAAADDLAQSERKLATAQKEAATQRERAASLDRQLHQVKEERASAQSQNVALASQLRQTEDQQQEYLAILQGAHMNLSPAGSPPDDLRRLVNALEILSEGAAIHARGLDDSLQLATAENKSLEEKLATVEGQIKNLTEKLSSAEARATQFRESLEQERRQISALRSELASERTEMHSLREKFAAGETGSDALRQQLKSEELKVAELVDRKAEDEGVIQRLKHEIEDLKREAGLAAEKQEKLRRHFEKRGERAKQLSERLFHHHDRIIRMLEQFGYSVSRAEDTPTLAIQRASKVNASALLSGNESSPAHASVMRRTISGSAPPQHYSDPSDLDTLYWTSDNDLTSESSKFSSFVSTLSRLDVDSTIDILTKRYKDVESLAKKYQKDSRAYRERTHRSQAEAHDKIAYRSFKEGDLALFLPTRNQATRPWAAFNVGAPHYFLRETETHKLASRDWLLARITRVEERVVDLSRSMRGNASMSATGDDGSMRSMDDENPFELSDGLRWYMIDAVEEKLGAPGTPSVGKSTVIASNVEVKGHMGTRKEHKSALGMGSGGATGTASMFTKTLTKSLDSRRSSSGSKKSLETKGKERGLKDVLPSSKVAPLAPITSDTDAERRHALPHDAKGETVAVADDDAHADADNENDDAEGQDATGSMTAQATSQTQGQGSVPSIVRRPTEASQTDREEAQVFEVVRRDLLLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF39</accession>
    <name>A0A1C1CF39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_02467</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF39"/>
    <dbReference type="STRING" id="86049.A0A1C1CF39"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02467"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02334"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="9">
        <location>
            <begin position="18"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="196"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT47088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="335" mass="35790" checksum="F30D729C58357D60" modified="2016-11-02" version="1">MGDKTAPAPYRLPENPTYGFVGIGVMGYGMAMNLRAKIPQTAGFVLCEINEARREQFIQECNLPVEVAHSPKEVAEKADIIITMLPRAPHVHEAFTNPETGFLSGVSPAAADTAPKLFLECSSIEVSTSTTLARQIHSQNLGVFVDAPVSGGPQGSNAGTLTFMVGTPSEDMFNVVKPILAMMGKEDNIYQCGGLGAGLATKQLNNYLGYVGYLGLCEVMNAGLLYGLDPKILSNVINASSGMNWNSLHHNPVKGVNPSASSARDFKGGFTTELAGGVIDDAVSLMDSVGAETVLAERVKKVFDEARKNEKCKGMEARSVWRLFAEDGGRDVRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFA7</accession>
    <name>A0A1C1CFA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ubiquitin conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_02234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFA7"/>
    <dbReference type="STRING" id="86049.A0A1C1CFA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02234"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02279"/>
    <dbReference type="eggNOG" id="KOG0897">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000107">
        <property type="entry name" value="Ubiquitin conjugating enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="1017"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="908"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="908"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="918"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="938"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT47151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1196" mass="131825" checksum="C2AEF2069B9A15FB" modified="2016-11-02" version="1">MGRKLFLSHLADAGRLGSKHIHGVRSPEEGIVIFTYVYPTSPFHDVDIQAYATDLEEYPDGNSFMLCTQDESAEPVVSTVLQKLSGSANGKSLGSLLSEVSESLTIAISAGAVVDNISQEVKDDADDFDFDFEGDSDNEFFGPVESKPSSSTDVDNMVLDSGVCSEVDAEKVARARADLAALKESGFRVGVFGNPATSGILCVSIRISKLGLSDEALEAWGIPRKRYLTLLIKYSRGYRDSTRVADDKDLTSSVQMRVGLCKHYKPSARHVLGVFQCPTIDSATSTDQAKDTSGDDFAIEPLFVSKALNQLLEERVFKIIYARHLYHLTWLGAEKFIAERQASASSDSVLDLTPYYCDDTAGAQNLPAIVLSDHMLQVPLPQASLPLIVMQFVLRHVVRCTEFCLVCHCPVDDSFEALKPYVCPKPLCLFQYLALGFGPSLEWEILTQPYVVDILVSFCYAAASNSRLKELPVGMNLLVPLIRQYESPDTEVLSYRGYSRKYNPAPQPTSTIPEPSFSGTWDKSTLRLVVDGAQGSTTASVQKIDEEAKNPAAQHAAVKKVKAGDWIAMYSARNAVIAHCRVKSVALPQIALHQPILVSLKPSVTDPEMGPPCVFKTSLYKVDCYLYDKNFDEMATASQQTAILALLDTLPGVNDMRMYLKLHGRTQNHNLKAWTDRISDSALNLLRWIVASNRSCILQVDEICEGESSEILGRPADRVGGMDAWMQFRFAQGAPDKEKRFNDCVKEQAEVSGTEYPTLFAWHGSRIANWHSIIRQGLHYDEIINGRAFGNGIYMSNTAMTSLTYSQHINLAESAGWKSSALKIANVLSLQEVVNNTDKFVCKHPHYVVADIDWVQTRYLFIKTKNVATNVDESVGTVYQQDPARLVYNELGRSISIPITAISKTRRSWSGISSPSRPQEKRPKTVHHTDQASAECRADDDDSVSSDAEDLAFLQEPNDRYDPTSRASLADTAAMEISDNKGHAGPPIDTDFVPGQLDSQSISFMEEPQDATPTATKALMRLLKDALDTQKHTAPATLGWYIDRNLIHNMYQWIVELHSFPGDLGLAQDMKAAGLTSIVMEMRFTSQYPFSPPFIRVVRPRFLPFSQGGGGNVTEGGAMCMEVLTNNGWSASLTIESLLLQVRLVLMDTERPARLAAPSRHGGQSAYGIGEAVAAYIRACEAHGWQVPAGFNTIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFK3</accession>
    <name>A0A1C1CFK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative enoyl-CoA hydratase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mfeB</name>
        <name evidence="4" type="ORF">CLCR_02507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFK3"/>
    <dbReference type="STRING" id="86049.A0A1C1CFK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02507"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02139"/>
    <dbReference type="eggNOG" id="KOG1206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60204at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF57">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="2">
        <location>
            <begin position="178"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="309" mass="33897" checksum="64BE257941568A85" modified="2016-11-02" version="1">MSGPGVGFEYPPTEVSWLKRDVLLFAVSIGCTVDELHFIYELHPKFAVFPTYPIILPFKKTTQEVIDFYAAQESNPIPGIPKLDARRVVDGQRLIQFLKPLPTTSEGRKFELRSKVVGVYDKGKPGTVVETEQTIVDKESGEVYTRAVGSGFFVGQGGWGGPKGPATVNYPPPKGRENSPDKISEKQLTAESAHLYRLNGDYNPLHATPEPGQKMGFGGAIMHGLSTWNFAAHALLKELGGSDPANIKEYQARFAAPVKPGQKLVTKMWRTGDVKNGWEEIRFVTEADGKVVLSNGRALIKVVDGKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFN5</accession>
    <name>A0A1C1CFN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_02514</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02514"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02157"/>
    <dbReference type="eggNOG" id="ENOG502S13F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5422068at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="191"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT47276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="358" mass="40009" checksum="AFECA5B3BA7174BA" modified="2016-11-02" version="1">MATPSHLTCLCGSIKEEGTLLASQTLPIENDICHCNTCRQHTGSLSAWYVSLKDSPSAESLGNATAYKTSEKYTRFFCKKCGCNAFVRSDRDGRWAACSGVVEIEQTKGMTGAPNAQKNVSRVLFHEYVGDAKDGGIAPFLTKLGDRDVPCYNTEPEEKGAEIFKESELQQLRETSLHQPAVAARDRGAAIEVSCHCGACQLRIAPPPYEVSSEGWYVPKSDRNKYYARLCGCRSCRLTLGFTLQPWAYVPPSQIRTVNDEPVVFGPKAEETLQIEKLRYYRSSEFVLRSFCTVCGATMYYQSFERPYIIDVSVGVLRSRLGNVMAGEWLEWDREIVSKRNECVDEELVDAWMSKSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG25</accession>
    <name>A0A1C1CG25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ZZ type zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_03301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG25"/>
    <dbReference type="STRING" id="86049.A0A1C1CG25"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03301"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01913"/>
    <dbReference type="eggNOG" id="KOG4351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="353"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="478"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="720"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="720"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="749"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT47470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="796" mass="86907" checksum="F7AC4D3BC38FA16D" modified="2016-11-02" version="1">MATPHPHTGPVGPDTPITVKVIIDGTNRRFKLPLRDLGATVLPQKLRTLLAIPPEQEVRFDRFSDSAGIYITLDSSNPAVYKQLYRAAKAKLKLRLRATLERKPMKEQLAVNVAMDPTKTAVPLPESRNTFLETVLSQPVGNGAAPSFKSFQKTCQYSPKCAIPGAFDLDVSNSEQPAKAASLYSNKDVYSLPTLPQMSDFPTTSYTIDCNSCGSSVPNEHYHCGICEGGDFDLCKACIDAGITCDGDEHWLLKRTILNGIVVPSTTETLPPKKLSKSPTAELVTPISPGQDEMSARDFVTCQECPDYDLCLSCFRDNDHGHDPSHSFKAQESEAVKGDMAIKALCAPGRGVRHEAICDGCNKDVYGVRHKCLSCPDFDYCATCIATAGEKHPGHRFAPLYTPIGFVRAAKPTHRGIYCDGPLCTSYKGYITGDRYKCAICHDTDFCANCEALPNNGHNATHPLIKMKLPIRHVSITTQHDSENGQKTAHLGDRPTAKHAATETARSTSTNAATQVQTVAEVSPTEVAPVMAQISRLNDIPPITLTQKDLQAWYVSDSTPDGTKIAPNHFVSQSWTLRNPGPDAWPAGCAVYYIGGDDMRNLDVLHPSSVSTMAVANRSNVLGSPLEPGKTAVFTVLLKSPAREGRAISYWRLKTPGGVPFGHKLWVDIEVRSTPVELPIRSHILPSAPVIVEAVDEPKEDDKSQDSSTMIFPKLEKESPISSVHDVREGQVEEVPAAVMEPTTKTEEQELLEDVESLELEESDSDDEDFLTDEEYDILDASDEDLVSEGHRSVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG29</accession>
    <name>A0A1C1CG29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_03482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG29"/>
    <dbReference type="STRING" id="86049.A0A1C1CG29"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03482"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01961"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="470" mass="51146" checksum="693A912D6AE2AFF7" modified="2016-11-02" version="1">MSIDLEKPATPTHGLEHGPPETRADGLHGDQAVDAAFESPFDLPTWRKWVITTLLALMTTAVTFASSIWSATIAVTSKEFDVSETVSLLGVSLYVLGFSVGPIVWVLQIPIGVVNNLPALLVCRLLAGCFGASPQVLVGATYADFWEPADRGVATAVYSVAVYVGPTLGPIFGALLTESSLGWHWTGWLSLMLGVVIGIPAFLFVPETYSPILQQRANRKSNLAQDSSPLTEQNDKKAPAFAEFVHKYMFKPAIMFCVEPMLMVMALYIAIVYGILYLTFFAFPYSFVQGRGWDPRTGTLPFLSILTSVVVSSFGVALYSKRYYRPRLRARGSVLPEDRLPLVMLGSIILPIGLFFFAWTSSSKISPVPQIVAGFFIGSGIMLIFTNAVAFLVDIYLQSAASAMAASTIVRSLVAAGFPLAAPRMYKSLGTAWATSVLGFLCVLAIPAPFLFYKYGRKLRQMSRFAPVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGG0</accession>
    <name>A0A1C1CGG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGG0"/>
    <dbReference type="STRING" id="86049.A0A1C1CGG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03626"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01781"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="298" mass="33687" checksum="2619930CF751FE08" modified="2016-11-02" version="1">MSLSSIVGTKKPRVASNEVNESLPLTRTGHNNMPLEVLNISRSAHELRLGKPLRRSLEAGLIDVLAGQMDSIDALCSGRRLKSLLGYRRHECINQIHWDLDRTIADANLSSLDREHFQPYAVNCLEILECWSYDGVTTVKRDHNFRLMRLDDGSQQVKPDEFKARLERWLKRQGQYQPLKPKGAGTLKGGIRLVMCDRPNAAARMTISRDAFEAIEAEFHLHEATLPAFLKEAGSLLMHRVNGQNEETTKVQIVLKVVQHMEISNCLLSLTYDVASNWTDAFICGDGIIFERICDRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGY3</accession>
    <name>A0A1C1CGY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative eukaryotic translation initiation factor 2 subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tif212</name>
        <name evidence="6" type="ORF">CLCR_03585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGY3"/>
    <dbReference type="STRING" id="86049.A0A1C1CGY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03585"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04584"/>
    <dbReference type="eggNOG" id="KOG2768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990856">
        <property type="term" value="F:methionyl-initiator methionine tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="239"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT47758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="371" mass="40659" checksum="10D157A2B3535189" modified="2016-11-02" version="1">MAEVVCNATQTPHLPSRLPSHADAEPSIEEFHLKPSAVRPTTANILTDTSFAPLQDHPLHDRKPRKSVAFSGDNTIMDENGEISEAPPSGPEDKVTAEKHSSPPTDAAVDEVTDMFAGLNKKKKKSSKPKTEDNEDGEVAADGDFDASALKKKKKKSTKPKTEGAEDFAAKLAQAGLAEGGPDEKQDQPSAGQDQDGDMDAGTGIWAHDATSPITYALLLKRFFETVNKNNPDILMSGSKSYKIPPPQCLREGNKKTIFANIHEICSRMKRTDEHVTQFLFAELGTSGSVDGSKRLVIKGRFQQKQIENVLRRYIVEYVTCKTCRSPNTKLEKGENRLYFVECLNCGSRRSVTAIKSGFTAQVGKRKRLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHA3</accession>
    <name>A0A1C1CHA3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHA3"/>
    <dbReference type="STRING" id="86049.A0A1C1CHA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03766"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04464"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11237" checksum="E609B834823AF8E6" modified="2016-11-02" version="1">MDPSVYEKMAALADNIMGPFADTVLRTAKFPPAGDSPLVVLDQACGSGVVSSHIMSRLSSDDRARLDLTCADISEPQIAQMTKRIEASGWHNARAVTNDAMVRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHK9</accession>
    <name>A0A1C1CHK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xaa-Pro dipeptidyl-peptidase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHK9"/>
    <dbReference type="STRING" id="86049.A0A1C1CHK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04420"/>
    <dbReference type="OrthoDB" id="416441at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12882" checksum="B98394F4757A2DD3" modified="2016-11-02" version="1">MSLPIRNDLHKVDDTIFDYIYEENVTIPLKDGRGIVRANVFRPKGLKTARFPVLVTYGPYGKDIHYSVHLLKCRKNSTHFTPPGKPQTQDTGLVMNMPLFVPTRLASVSLQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI07</accession>
    <name>A0A1C1CI07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding La domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_04034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI07"/>
    <dbReference type="STRING" id="86049.A0A1C1CI07"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04034"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08249"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08029">
        <property type="entry name" value="LA_like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
        <location>
            <begin position="139"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="240"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="515" mass="57685" checksum="5069DBDBCB9975A5" modified="2016-11-02" version="1">MSVEDAVTEGLADPMDDNASAAEEAKRMLAELEGEKAATDTPAGTNGVKRDDTTVEAAPKETEPAVKGEDEPKKEGYDDAEDEERERREDCGPRDYNDRGHRGGRGDRKGYHDRGRDRGDRDGYKPRNHRENNKFDPTTKEITDDPAEIRKQVEFYFSDSNLPRDKFLFGLVGGIENKPVPLKTLHSFKRMQRFQPFEAIVEALKGSKEVELTDNDTAVRRIKPLAEDFFKVIPGTSDPRTVYVKGFGEETPSSQFDIEAFFDPYGPTKAVRLRRNDEKTFKGSVFVEFETEELAQAFLALDPKPKYKGRDLQIMSKTEYTDKKEADLKAGRITSNQEERRGGKKGHREQRGDRDDDRDWRTRRDEDQKRGFRDDKRRGDRDRGGRGGRGGRGGRGGRPEWRGGGRSKAPETDERGIPSIKSTATEKDSARDEALAKAKAAVEADMKEQEAQKVGNNVETKDQGPTAVADSSAADIDTSAGKKRAREDDSAEAEVGREVKKVDTKTEPEVTEAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ20</accession>
    <name>A0A1C1CJ20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formyltetrahydrofolate deformylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">purU</name>
        <name evidence="4" type="ORF">CLCR_04299</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ20"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ20"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04299"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08637"/>
    <dbReference type="eggNOG" id="KOG3076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4239773at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004684">
        <property type="entry name" value="PRK06027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706:SF1">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036480">
        <property type="entry name" value="FormyFH4_hydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="281" mass="31784" checksum="6DD46E007A660A4C" modified="2016-11-02" version="1">MAHDHILTLSCPDKPGIIHAVTGLFAKNELNILDLQQFSDRTSEKFFMRVHFGPAPDTKFLMPSLDQLAADIHMDWHLRPVTEKPRVLIMVSKIGHCLNDLLFRQKTGQLAIDVPVIVSNHPDFQPLAQSYNIAFHHLPVTKDTKAEQESRILDLIKEHDIELVVLARYMQVLSPTLCEAMSGKIINIHHSFLPSFKGAKPYHQAFDRGVKIIGATAHFVTADLDEGPIIEQRVTRVDHNMTPKELVDEGSNVESQVLAAAVKWWSERRVFLNGHKTVVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJB8</accession>
    <name>A0A1C1CJB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ester hydrolase C11orf54 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_04233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04233"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08650"/>
    <dbReference type="eggNOG" id="KOG4048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5119241at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17298">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015021">
        <property type="entry name" value="C11orf54_DUF1907"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204:SF1">
        <property type="entry name" value="ESTER HYDROLASE C11ORF54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204">
        <property type="entry name" value="PTD012 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08925">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01168">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DUF1907" evidence="7">
        <location>
            <begin position="24"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="341" mass="36722" checksum="C2E4BDB7684A4008" modified="2016-11-02" version="1">MSSGSLPVKKVPLFPPSLSTLAESISAGLSSNFRHSSCTVSTPPDLTLPPYHLAAPGLTGSPRIVDIGGPPNLSPAPDLTKKYDLLSVAHQAEMSTSTGFMLGAGAGPFHVVGQNSELMPNFAYGTAAGGQDLRDVRNRTHYAKIKPDESVCCARIPNDSTAFALMCNLFCSDGLPGPCLHVTSKSRNGPLNFTQTIQGALKSSFGDRLISIGGVFLIKRGTAKLHVMPDFPSEPFKSRDDVDKWLRYFDMGFTDNEHGPLVCLTVLHSGDDDGLALRMEHTHCFTVSGSGDATVDGPAETTKGGHYHYDLDDTKEEIEYEGWFNVARYLYRLDQPGVRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJM9</accession>
    <name>A0A1C1CJM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04934"/>
    <dbReference type="OrthoDB" id="4161729at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="402" mass="43891" checksum="82F3A546497AF4F7" modified="2016-11-02" version="1">MASITTTTTTTHPAATNSHALSSHQLVTPSSSALHQLPIQISLVAATGTSSPPSPASNGPPAMNTSQPPSTQRPPNARQGILCNVLPTALFPKTVNWGKCIFNGAMVVLSITGVVFAVYQTLMSSWTARKDFRDDCFNQRVSGEYPILPVTFFARLTDTQQSFGNWSPTCDEVVVKGLDAPPQFPGLPLTKRGALQAHHALRAILLTSDDAKVPWLITCATLVITMYSRACRASVCQHTSRSKPPWYSKFRGLLAHLDPVKGLVLIIESVSLSATVLILYVRWRFPQTSSIPHYVAMTLLFATRLCANYLLLYLEWRYWTGKAGCKADVEDEMSRRTHHTLSRPRTSTALMSFIHGSLLHLGPLYIVDYCDEPSAAAVLVMTAATAIAVLGRSGGLGKRKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJN1</accession>
    <name>A0A1C1CJN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative nucleoside-diphosphate-sugar epimerase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_05053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJN1"/>
    <dbReference type="STRING" id="86049.A0A1C1CJN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05053"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03180"/>
    <dbReference type="eggNOG" id="ENOG502QV9W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="308" mass="34651" checksum="E15D22DC55089716" modified="2016-11-02" version="1">MPELIVLTCASGRQCSAIIPHLYSNPQYTLRLVVNSPSSRERLSKQWPDAEVIQADLHVPDECAKIVTRATTLLYIGPPFHPHEVTFGMNMIDAAVRESKTQASPFRHFIFSSALHPELTKLVHHSQKARIEEYLTESGLPHTILQPSTFMDNFLGQLINREESSKAAPTFRAPFNPDVPMSFSCLADHADVAVKIVRERDPHLYATYQLASTLPITLREYVAQVGDALDTTFEIQPLPFEQAGKMFVALTWGQGQDVGQEFKDGPERMLLYYESRGLYGNPGVMEWLLGRKPNTPADVARLKMEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKB9</accession>
    <name>A0A1C1CKB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKB9"/>
    <dbReference type="STRING" id="86049.A0A1C1CKB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05169"/>
    <dbReference type="OrthoDB" id="4159978at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22958">
        <property type="entry name" value="DD_DPY30_SDC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="183" mass="19342" checksum="A09A8E96FCE383DA" modified="2016-11-02" version="1">MSQAVSNVPSVISNAGNARQQVPLRDYLNARVAPFLKKAITESLNAEAEFPLQWLGECLIHQSFLYEGNPDRTNIREKFLYTFDDPKPVEQVSAESAAPPPPATQSATGGSPQGVPPQEQSEVSMAEVVPEISTQQAPPAQTNEISAPQATVTPDIPPVNGVKEEGGATNQGSDGDTDMGGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKD7</accession>
    <name>A0A1C1CKD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05008"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02935"/>
    <dbReference type="eggNOG" id="ENOG502T57E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="339" mass="37053" checksum="7376BFAE0DFB6354" modified="2016-11-02" version="1">MASTPLDVPPGLLDLPAEVRNLIYKFAFQQPKPMRLRCPSQRRLRPSRPSRDDARGLLDTCHLIRSEAITFYYSLNALVFRSEADALAFMADPDIHPLIRPSLTHIAVDFGDTNDADAILKDHISLVDSCVGSLPRLRALETRFYARTLDACSSSHFRTLAMAFDSLDTDINTPPSPRSPRSSPRHSRQSSISSASSSPASSPLSTCSSICWESKPEPAPLPVPDMSALQAEVLEQYCFTPSAAIAFAHSKLKFSVAASSEHYPGLKHDKLICYNLRIGVDGVANALGPAKEAVKQRISRVGMLPRPLSDMYDDAIDGGFQQRVRSTIASCARIDVGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKF4</accession>
    <name>A0A1C1CKF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05196"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02913"/>
    <dbReference type="OrthoDB" id="3540486at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="178" mass="20844" checksum="56FBF283D3C636CA" modified="2016-11-02" version="1">MAGISLQTLPLEIRLQIWSYLVQPTKIYPCECALKAQQCQAHRLGGCCDNNSTYKHCDTRVLRVSRQLFEEVQPLVRRAAKERTFMLCNNLCLDNFFKALDERDWKWVKHLRVDLFVGWGSDNQDDWFLGQMHRWARRYVAGSLSQYDQGRELTIQPADEAKEDKDGRRSLTVDIYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKL9</accession>
    <name>A0A1C1CKL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04970"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02865"/>
    <dbReference type="OrthoDB" id="4160677at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="370" mass="40768" checksum="FE778FD7E623440B" modified="2016-11-02" version="1">MSSFQSHQPSEFGFSPRHPRAYPSSSHTAIITWHLPLHICLLVALVVAKLVSLWWRLPNGTKGQAHVDGHSPDKPSCALNAVQSSSRHPKVRLVWEASDQVFCKGEVQGHAPCHGGRLRLELDFNDLQTCESTCARTTSERTPQPRPVPDSSPAPATRSASGSAHQSCKPDVKSFPLRFGVAPRLVPVQELDGDNVLMPCSKDNSGRCAGLRGGMGSRRTLDTKANPDADADADADADADADTDMDKDSVLETKSYCTTPETDTETNTGKNKHTGRNADEDIDAVIHDHHDSHAHHMTSYLQLEDHIEEVIREFDELQRHRTGSLLREALTHNERARLIALYARLQRRLEEHMRGLGVEVDGSETQLDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLP3</accession>
    <name>A0A1C1CLP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HPP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_04935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLP3"/>
    <dbReference type="STRING" id="86049.A0A1C1CLP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04935"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03333"/>
    <dbReference type="eggNOG" id="ENOG502S3SU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="3">
        <location>
            <begin position="91"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="400" mass="44852" checksum="8391BBA3898F48BF" modified="2016-11-02" version="1">MSQQSSSTQAGRPQPSKPATTPFDIDNYLNPYVPRNPLRTLPTHISYWFGYRQHATQRHPYFSLHSSINDLRLPRWYYVWHLHTAFLYSSMLIGAFCGVAIIENVFLALPQLSGHTVPIVIASFGAAAILEYNTIESPLAQPRNLILGHFLSALVGVGITKLFLHLPPDRFEDLRWVAGALSVGLASILMSFSKTIHPPAGATALLAATNLEIQNLGWWLLPLVLLASMLMLASALVVNNGMGRRYPVYWWTPVDLQALRDQRRKERLTRRQKEEADVEKAVGSAEGRDHSLSQTDTEAAVSNEDLRKEIPAEQERDRPDRANRAVSYSAADRVPRPERETGPESEGTEGSGGKSTSQVMSGESILVTSHKIVTPEWLELSDWEDEVLRILMERIREGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM30</accession>
    <name>A0A1C1CM30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM30"/>
    <dbReference type="STRING" id="86049.A0A1C1CM30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07646"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650902" evidence="1">
        <location>
            <begin position="19"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="158" mass="17586" checksum="4B3F59EFFE49331B" modified="2016-11-02" version="1">MVAPRSLIVAALAGLALGLPHPEADVEKRGYYTSSYPYTSTYATSVYPAYTTYPTTTYYSTYYPTSTETVYSTITDYATVTDYATVTDYATVTDYATVTDYSTVTDYSTVTDYSTLYSTLYSTLYSTLYSTFYSTVYSTAYSTAYSTVYSTVYSTVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM77</accession>
    <name>A0A1C1CM77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM77"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06687"/>
    <dbReference type="OrthoDB" id="10532532at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="770" mass="85528" checksum="3D036F2743F18C0B" modified="2016-11-02" version="1">MELVQIQVCGGNAPFSYKPPALCAAGLSPLASHRSSSPPVLDIDTARSARGKATVAADMADKFHSRIEPIIEGTLKFIIHSTGVATECSVCLLAQGESDLFFKGAEHAPVDFGLLAVPHNLAVEAKGPAERTFEALRKYPHLKEFLFGSEFKSCLLLEMDHPTRAICYKVHIKPGQQKHAAAFLVYTVAAPRVVKLIPSWIYDYHFDYRREYTLRESTGSSYQARVEDQAPLPWDFCGVPLGRLAENVQDMAAFCSGQTKSWRNVSNDLEYERCPRPQTCGFHDLIPRTRRAPLGHSPDILLIDAICEKFRAYGVHYEARLMDLAPAIGDFAFVHKQSGAKLVCASGFRLRHKGRTSIRQRYFSAIYPVDVYLVQLEPRSACSGWLFLPRDILPDTWFDGSVDKDDTTLPAWSLDATSLSRYLIAVELDDRDGQPFVARLEEVMNQCASLQTRNLARPFYLPPASSSPDTAPSSRAETTPSSHAGCDGAPRVQRKDIPNEPKDTWSQLVFESMEVGGSTDSVSNCQRCDSHRYSSWADILRGWGKFYPLRTNPMQGCAFSPFMSQSFVQADARTPFVRVHFACITLVDTLLAFTYHDRRALKPAGNKDDRSIFVLAPSSTTGGQTAGTLMEAATVRYVVPSEQLASDFIEEWYGGNTHSDAGKPIPLYLRGGDLIDAYRVPLDQVVWKLLSLCRAGLSQFFGDEQTRAGSTVQTVKYLTTTTEILRHYSTSLQVQASPQAGDRSPPRTKNKGRPPRMCTNCRALKLPRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM99</accession>
    <name>A0A1C1CM99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM99"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07743"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="116" mass="13387" checksum="59678015BCE33427" modified="2016-11-02" version="1">MAVRLSPEFLSGLAFGITMLLVALLGYWLDHRRRAAAHRSPRLPIHDHPTRPIVIHYHNWNHPPPIWWTSHPHPRPQIEMPRRHLLDPPPRATQGRVIEVEDQAEQPADVVVNQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMH5</accession>
    <name>A0A1C1CMH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07809"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="90" mass="9904" checksum="ED07F9B0CCE5C0CC" modified="2016-11-02" version="1">MLQSTEPDVCGSTIRLEVLSAKSPSKFMLILSTTDLLSSGIVLGFVLKRVSRGNAAFLPQSKSVLVTFDFASRFHLRPPLLEEFQASFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMP9</accession>
    <name>A0A1C1CMP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMP9"/>
    <dbReference type="STRING" id="86049.A0A1C1CMP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07067"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08687"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4160849at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="279"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="347"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="497" mass="54761" checksum="79826BDCBDB521CB" modified="2016-11-02" version="1">MLRWATLSLRPLKREEMATVLAPPSCATLTPAEVTKDRLQLCSGLLVLDGDTVTLVHQSFKNYLLRAEPDDDPVLEYYKIDPDKANSEIAVRCLEFLSKERPSASVFSNALDCERLRLQRDVTFLSYATASWPLHARASASFGPENHSTFSFFFSQKEATGTSWFVEYMSRLGYYFDKNFLHDVFHSSNALFMVATALLISTLALKMLSLAFSIAIVSGNMEIARFLLSHGAHVNNAYKRDNTSIGAGTPLHLAAVHDREDVVKLLVSRSANLEAKDHNGKTPLHQAISSNRSSDFMLQLLLRAGADTAARDLQGWTALHTACYRSDDSATRILLEAGANVNAIDRGGWTPLHVAVTQFDNHLARVLIDGGANVNSRTKIGETPLHFASITASPGLLAMLLHQGADIKALDNTGKTARENLQHMFDLGLVKRFGPQHVRDSALVEVRDKLEMLQAAEEGRPLPVAACSRSMNRSSVAQYSAPPARLDEHRLHGIMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN55</accession>
    <name>A0A1C1CN55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN55"/>
    <dbReference type="STRING" id="86049.A0A1C1CN55"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07636"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08831"/>
    <dbReference type="eggNOG" id="ENOG502SH99">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3511549at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02210">
        <property type="entry name" value="cupin_BLR2406-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052535">
        <property type="entry name" value="Bacilysin_H2HPP_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40112">
        <property type="entry name" value="H2HPP ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40112:SF1">
        <property type="entry name" value="H2HPP ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="87"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="194" mass="21195" checksum="7E9337FF4D7BC1C4" modified="2016-11-02" version="1">MSEQQHSHSHDHSHDHSHGHDHSHSGPAHLFQATSPDDQPPDDWKESGVRVIPAGSLDTNTPQTPGMNRAAAITNARVGAQKLWAGTVKIHANAKTGAHHHGHLESVIYVVKGKARMRWGDKLQFTAEAGPGDFIYVPPYVPHQEINAKEDEELECVLMRSDDSAVAVNIPDLVPVEDPEQVKWVDPTHPTGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN57</accession>
    <name>A0A1C1CN57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_06836</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN57"/>
    <dbReference type="STRING" id="86049.A0A1C1CN57"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06836"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08869"/>
    <dbReference type="eggNOG" id="KOG3720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="438"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT49958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="592" mass="65131" checksum="BA15616AB02ACF86" modified="2016-11-02" version="1">MTSIDFRPPYSQDELNKLYPKDLELRLVQVLLRHGERAPVSARFGNAGLPAYWPYCNAAQRLRSVAMTPEDMSEWNSLQWRRRLEMFGEDDGPVIAAGPKGQGRQTTYTLGSRLRHLYIEQLRFMPSLIANADLIYLRATPLPRALESVQQTFWGMYPLSSRTAAFPSPTIVTRTPADETLFPNDGNCRRFAQLSRAFAQRTADRWNDTSDMAYLTKLIGKWMPETSDKRVAVDSHPRLSGIMDTINSTLAHGPETRLPKEFYDPKAREIIDRIGVEEWFSGYNENREYRMLGIGSLIGDIVERMTSKIEGAGLSINEIGGENGRLGRGRGGETGIRFALSGCHDTTLAGVLTGLGAFNGEKWPPYTSHIAFELFRVKEPQNQDRQSAPDADFLSPTTPASTEPKTEAAAAPSSPQQPGLFASFLGLRSPFGSGSGSQGDDTPSNGTFTSSRDPSSKSTATSRSDPLSTPSLTRQSSLSPSISPADLIARKPYSSLSEDQKQRLQGYYVRVRYNDKVMKIPACAKPGNHYADDESLCTFEAFKRVADGFVPKNWKVQCGQNLDDGAGGKSPLLKGPGLDQPPQLAGQIGEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN60</accession>
    <name>A0A1C1CN60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN60"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07803"/>
    <dbReference type="OrthoDB" id="10402895at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="94" mass="10696" checksum="7C7F1D991B622979" modified="2016-11-02" version="1">MASIIVGSALLIGHAIHERKEKKREKARLTEEQFSDAHGKPALVSSRRLRKQQQVEMPELPSYESVVSERPGFSTVRDGDEKPRRRSEDNSKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNL5</accession>
    <name>A0A1C1CNL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endo-1,3-1,4-beta-D-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNL5"/>
    <dbReference type="STRING" id="86049.A0A1C1CNL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07004"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09016"/>
    <dbReference type="OrthoDB" id="10019231at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF55">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="422" mass="47618" checksum="5F56643E8C190876" modified="2016-11-02" version="1">MSLSPCCATGFRWEGTPKGKETTLSSNKAYVTGTNKEAAVLIVHDIFGWTLTNARMLADHYAEEADVTVYLPVLRPRGNLRCFRSTHAVRFSTGRIDRIRTRERAFALDEYAHTNLSLRGSFAGEIVAPNRLDPAYAGEPFDIGDFITRNNKDTRWPEISSCAKALKTELGYKKVGAIGFCYGGWAVLKPGAKENAFVDCVSTAHPALMENADIDAIGCPVQFLAPEEDNTFTPEMKEYTLKTLPTLGIDFDYQYFAGLKHGFATRGDVNDPKQKHGLERAKNAAEHLSTLPSLRRHFSLLARWSIFMMAIFRLLLKHLLHLVEELRRLQWMLTRHIVKRRRGDVVRLAVADKGVVLEQVLYFRRVEGRLFLEDGVGFVSGKKRSTCVHGRRKKRVWGKGGVEVCRDVLGNVFELELHVQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNU5</accession>
    <name>A0A1C1CNU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenine deaminase</fullName>
            <shortName evidence="4">ADE</shortName>
            <ecNumber evidence="4">3.5.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Adenine aminohydrolase</fullName>
            <shortName evidence="4">AAH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AAH1</name>
        <name evidence="6" type="ORF">CLCR_07339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenine + H2O + H(+) = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNU5"/>
    <dbReference type="STRING" id="86049.A0A1C1CNU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07339"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05812"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01962">
        <property type="entry name" value="Adenine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028892">
        <property type="entry name" value="ADE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF7">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="365" mass="40261" checksum="F1707E24F7F13DD9" modified="2016-11-02" version="1">MASQTTTQHLSPTMDLPSFLSALPKAELHVHLEGCLTPSLARSLAARNNLPLPPSLSALDQTGSTYSFHDLTTFLQVYYPNLSVLQTAQDFADLAVSYLTVAHAQNVKHCELFFDPQAHTSRGVPFPTVVRGYQAGIQTAQRGLGISASLIMCFLRDHSAEYAMATLMSSLPFKDVIIGVGLDSDERDNPPAKFAAVFQRAAKEGFLITMHCDIDQPNTLTHIGQAIHEIQVDRIDHGTNIVDSPELIATLKQRGIGLTACPISNSIVTDDFKGKEIIELLRQGVRVTVNSDDPAYFRGYVNENMLKLASATELNVTRKELIQLQRNAFTISWISSWKRNHFLQLLDEFEQLTLGSEEAQVPNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP95</accession>
    <name>A0A1C1CP95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Siderophore iron transporter mirB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mirB</name>
        <name evidence="9" type="ORF">CLCR_06890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP95"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06890"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05688"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="604" mass="66516" checksum="D0EC2873BFAE05E0" modified="2016-11-02" version="1">MKFNIARVTPATFIPVALNEKQNDAEAATPSCDPKEVRVSSESPGTADSDSEGVDKNAQVGVQKIEATTSVWSKNQLIAAYILYVPNATIFLIYFVDSMQQQITGVLTPYVTSNFQRHSLTATTGILSQIIGGLSRLPLAKILDVWGRPQGFIIMVFLLVIGLIMMAACQNVETYAAAQVFYWVGYNGIGYALSIFIADTSHLKNRGLMYAFASSPYIATTWIGGPAAESFLDGAGFRWGFGTFAIVTPVVCSLLFFLFIFNYHKAKKAGLMPVSESDRTILQSIQHYAIEFDLFGLLLITAGLALFLLPFSLYSYQADGWRSPMIICMIVFGVVLLIAFALWEKYVAPKKFIPWELLTDRTVLGANILAAVLFISFYIWNAFFYSFLIVVNNQSVTHASYVTNIYSIVACFFAVPVGLYIRWRGRFKNISLYFGLPITILGVALMLRFRQPDTYIGYIAMCQVFIAVGGGVLVICEQIAVMAAASHQHIAVVLAVEGMFSSVGGAIGSTIATAIWTGQFRDKLLKYLPAEARADVDLIYGDLVTQASYPWGSPTRDAINRAYADCQRNMLIASTAFLALAVVSVAVWRDIYVKDLKQVRGRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPH1</accession>
    <name>A0A1C1CPH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CLCR_06622</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPH1"/>
    <dbReference type="STRING" id="86049.A0A1C1CPH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06622"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05600"/>
    <dbReference type="eggNOG" id="KOG2103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651010" description="ER membrane protein complex subunit 1" evidence="12">
        <location>
            <begin position="20"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="936"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="14">
        <location>
            <begin position="19"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="741"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT50400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="965" mass="103338" checksum="D3CAB6460E1D57E8" modified="2016-11-02" version="1">MRWYGVVSILTSLLLPVTAIFADDAFHIDFHHALLGSPQSSTTFFHKPNSNTNASLLYTVSDKAILGAVNPKDGSVLWRQPLAGRPVNNASTSYLVTAERDGQLVSGHDRTVACWDGLDGRLVWDYTVPEGTRIGGLQAVSGAEPVTGRITQDYVVLALPVNPIAHTTIVRIAGDGSGARWHHVDSSTPHGTPASVAVSTEHIYFITTSHGLLTSNKATITTLDRATGKEVSQTSTPIESEPLGTNGQYVAAACSNAPFLISTDKSFKSFKFSLLDSPKVSTLALDDKGDDIEDITVVHPCHAAAATHFLLHIKGKTRQWAEIYHINIKTADVTKAYSLPATAEESLFAAGNIEETVFFTRFTEMEVSLYSSASHGQLTRWKKTNFKTSPGSSKPHATVEVVSRGKSSYAVRVAEFSSSGDWSLIRNGELQWSRPEMLAYAKIAAWDENGAPDALAEELDLESSINPLTAYIHRVKRHLHDLASLPEYLRGLPDTILQSSPGADATARRSLVGSKLIVLGTSRKEVIAVDATPPGLLRWQADLSAQISGDNEMRSIGVDSGRVSIYLSDGSLIVLNATTGALIEQQLGSIPVAELIHIPGSPSPAVIKVGADGVPHPATDFAPNTAVEGNIVVTLSPEGKAIGWTIGQNVEKTWILQPQSGFKIVSAISRAAHDPVASIGRVLGDRSVLYKYLNPNIALLVATSDSSSLTIYLVDAVTGSVLHTATHNGVLSDNVIPAVLSENWLAYTFTSFDPSTSGISHQLVISELYESSAPNDRGLLSSLPTNYSAFAPDAAAARPHVISQAFTIAEPISHLAVSQTAQGITSRQLLATLPHSNAIVGIPRELVDPRRPIDRDANATEREEGLLRYNPVLDLNPHGYLTHTREVLGVESVLSSPSLLESTSVVFAYGHDVFGTTVTPSMAFDVLGKGFNKGQLVLTVLALGAGVMALRPLVRRKAIEGRWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ22</accession>
    <name>A0A1C1CQ22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ22"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ22"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07689"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05419"/>
    <dbReference type="eggNOG" id="KOG3139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47542">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASES (NAT) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47542:SF2">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASES (NAT) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="169" mass="19222" checksum="D387089EB47D6108" modified="2016-11-02" version="1">MGHPAAGVSSPPRPIFKTIQQLPRSDVSSTLEELRTLERKSFAANEVFHLDDKVVKQRNLEILVGFNHRSTGSRVVAYAVSVTSNRRLLLHKICVSPECRRRRIGYLLMETLIGNAKRRFCRGIDLWVDEANHAAKGLYFQHGFNVQQTVQDYYSPGRNGVKMTLDLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ68</accession>
    <name>A0A1C1CQ68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NIF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ68"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07059"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05404"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000089">
        <property type="entry name" value="NIF domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="304"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="522" mass="58401" checksum="D500F37E38E7D9C0" modified="2016-11-02" version="1">MNSLNLISSRVIGQSTSPSRPRSRSQGDHLKQDGTDDEFRGRSYSAELTAQLKKESSPLFSEKLSAGSAAGEEDEKQPLLADTPVTATGWPTWVKRLAEAITAVLAAIGAPVVYIAKYFRDPNGMFSIVPRWVRPERGPSGSSAHGGGPTSAQQDGTWVSEKPQRPTNRVLQETKLRHSYSSDSLETTTSDSDAEQRRAEQTRSQQKSKRDKATREDSETRRSSIRIKEQNDPAFKRRKQKKGTSPLADSTPLTVDNIKSPRSPSPSLKMTRYPHAPQPPRPLIPRRQPSYANAIPRVPTRYGPPLQQKTLILDLDETLIHSLAKGGRMSSGHMVEVKLNAPVALSAPQPGQAAPVLGPQHPILYYVHKRPHCDEFLRKVAKWYKLVVFTASVQEYADPVIDWLEQERKYFAGRYYRQHCTFRNGAYIKDLSSIEPDLSKAIILDNSPVSYIFHEGKHIWPSFARSKLMRMGSDNAIPIEGWINDPTDNDLLHLIPMLEALQYVTDVRALLALRRGEAETTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQS8</accession>
    <name>A0A1C1CQS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07789"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="105" mass="11967" checksum="C68313D563F845A1" modified="2016-11-02" version="1">MALGKSGKFGRLLVDFLSEEHSDEAGAVVHAGIFLEPGRSVCIRRYGALLRVHYADMHRDKMGCFMTDESLNARQDFHFLKRSRVARHKLELRDVAKSAPIMHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQT0</accession>
    <name>A0A1C1CQT0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">High-affinity glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_08430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQT0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08430"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09512"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT50867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="498" mass="54033" checksum="B442AB4F21D2055B" modified="2016-11-02" version="1">MTPLTESLQTLGFDGSMMNGLNILPSYTDYFTLTTTTLALNTASVWMGSAIAGITFAKVPDWIGRKWALLAGAVVTIVGVILQSAAQNIAMFVIARIIIGFGTGASSIAAPVYLSETVPVKLRALSLALLYDFWYVGGLIAAGITYGTAKMDSTWAWRLPSALQGLFSLLCIILIPFTPESPRWLQNQGRSQDALLALAQTHSNGDIDDPAVMVQFRQITDTLAFEKSFERSTFVKQLVDSSSTRRRIFLVCTVAVFSMLSGNNIISYYFGTMLTQAGVTDPTTQLEINIILNAWCLVVSLVGTAMADKLGRKSLAAISTGLLTVFIFLAGALTKVYGDSHNNHAGIYGTVAAIFLFQGAYSFGWTPLTVLYPPEVLNYGIRSLGMGIYTFLVNGVGLMVTFSFPFALEAIGWKTYMINGAWDVVELVVVLVFWVETRGRTLEEIDENLDGEVHSAAPTLQAIMGVAPDERAEIVDALALGKDKDVEVRGEVREVTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQT5</accession>
    <name>A0A1C1CQT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQT5"/>
    <dbReference type="STRING" id="86049.A0A1C1CQT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08704"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09504"/>
    <dbReference type="eggNOG" id="ENOG502S1RV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10461077at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="287" mass="30461" checksum="50F1F7996D04A7BA" modified="2016-11-02" version="1">MPVFAIRRFLPERMSRVRSASNIFIATSTTPSPTWSDCELDPTQLSQRPLVSIDNLTPSRDQLKQHDDDDDDHHRRIILGPPPQAKPPLLKPVRPSGMIALAGTTSTAPAPAPVSSSSVWNDWTSIAETSSVPAPVESTPSPVASWNDWTSTVETSYTPAAVESTPAPVASWNDWTSTIETSYVPAPVESTPAPVASWNDWTSTVETSYVPAPVESTPSPVETWADWSSTVATPYVPVETSSSVWYSSVAPASYTAPPVATFTGAASSNGKPAMAMVAGIVGLVALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQW7</accession>
    <name>A0A1C1CQW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp70 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQW7"/>
    <dbReference type="STRING" id="86049.A0A1C1CQW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08070"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09517"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF79">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="725" mass="79610" checksum="EA333CCEE4893C18" modified="2016-11-02" version="1">MSSRFKSLGFGSKRKSSANIQTSSTASTSVASPNGSTSTAGTPPPQNSSQTSLPPMNPNQPAAPGRPPSYSYNSVQGRPQSPMPPPQNQMAHHPAPIDTRAGAYVGGAPQLGPPQPPGYGGAYGHQQLGPQPGIQHMAQQYPPGARPAAEVEGAGRSKAQLIVGIDFGTTFSGVAFAFATNTEAKEDIITEWPGAGNQTKQKIPTVLYYDQYQKVVGWGPDIADALAPTGYPKPGVQKVEWFKLQLMLSGNTYIDPINLPPLPPGKSEIDVAADYLFKLRQAMRVQLQKTLGEVFNREERNIRYFLTVPAIWNDAGKAATRAAAIQAGFIRDENDNRLTLITEPEAAAMFCSKTGLLNLKIHDAVLIVDCGGGTVDLIAYEVEEETPFTVAECTAGSGDSCGSTALNRNFSNILRAKIRKMKLPDGSKTAGRVYAKCIMDFENRIKADFRNNGQKWAVDVGIEAEFPEAGIEEGYMTFTNEEILQCFEPVVNRILELVRNQIIAIQAQNRSLQNVLVVGGFGASEYLFQQIKLHVPPQFQSKVVRPMDSVAAIVKGAVTAGITERVITSRVARRHYLMATLQPFKEGHHPEQYRVPSLDGKDRCKYTRQIFVQKGERVKIGEPVKVSFFRQVAPGATLMYEDILYACDEDVCPEYTKDPRIKEVVTLTSDLSRKNLEKDFERMDTPQGTFYRVYFDIYLTLDGSEFNAELVCQGEVMGRCSARFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR84</accession>
    <name>A0A1C1CR84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR84"/>
    <dbReference type="STRING" id="86049.A0A1C1CR84"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09148"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09655"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="164" mass="18450" checksum="89E3AFF9CD4A8E04" modified="2016-11-02" version="1">MHPPSRDTGPQVPSTTFNFTFVNQAEDLVSLYQRKIINKEQRHTIRSHVMQRVRQWESAQGRKRSTGREHPKGPAKSKARKKSTDSEATVRNEAKVSCANDPLNLADSDRTTLIRSPRQSPRLNLSPGVHEFDPFDTLPTNTLPHQSSESLLQYCELAVCCGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRT6</accession>
    <name>A0A1C1CRT6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08754"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06861"/>
    <dbReference type="eggNOG" id="ENOG502S2DU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF108">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="15"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="371" mass="41221" checksum="BB284D81CF584DAA" modified="2016-11-02" version="1">MALPNRQQSLPGHLLPDREIHVVVSILSGRHKAKEYYEESIKPLLDRHEIQYFTHQTTSARTIIELTEKLFIPNARRGVKQTIILLSGDGGIVDIVNTFTTVLNRSNDDMRAPSIFLKPAIVLIPMGTANALAWSSGVAQDALKIMMDGRPKSLPSFKVTFSPGAQLLVNEGQDREALGDTEDGESVTYGAVVCSWGLHASLVAMSDTAEYRKHGLERFKMAAEQLLTEAHVYRGKVKWRKQNSDWTEVAGTEHAYILATMVSRLEEHFQISPKSRPLDGTLKLVLIGAEPASEIMRILGLAYQAGQHVTDPKVAYEDIEGLRIDLDEDDDQWRQICVDGKIIAVPKGGWMEVTRIPGTGMDARRVVELVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS80</accession>
    <name>A0A1C1CS80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_08186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS80"/>
    <dbReference type="STRING" id="86049.A0A1C1CS80"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08186"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06737"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF12">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="59412" checksum="7ADE5BDABD35032A" modified="2016-11-02" version="1">MLPFDSVQHQNVWVLCAVGAALLLAFGLVSLKPRTKYRYPPGPKGIPVFGNLFQLPPAYPGAKLMEWGKQYGDLFSVQLGARRWVFLNSAETARELLDRRGRLYISRPEFPVTQDILSGGKRIVMMGHTERWRQLRKIMHQLLMASNSETYKPFQDVESRALVWQYLKRPDEFYRHGARFANSVIFSVVFGRRTSMQDENVRLLFSTIDDFLETQTSPSSSLVEQFPWLVRAMPRSLQWFRPKAERVYRKTLGVYTAFFDDLERRIEQGENPECFARGMADLATKYGFDKAQAYFAAGSIIEAGSDTTRNQINLMLAAAAEYPAWVANAQKQLDEVCGHASRLPSFDDWHHLPYIVAVVKESLRWRPNMTASGVPRALIEDDTYRDFVFEKGTIFVYNHFAISHNEKEFARNEVFLPERFLNEDLQELLKGHLGFGTGRRVCPGWHVATRNMFIAFSRLLYCFDFQEVPEAPIDDWRIDPLAHDHPPFQIRITPRSEDHVRLIGIECARAGEELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSC1</accession>
    <name>A0A1C1CSC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_08420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSC1"/>
    <dbReference type="STRING" id="86049.A0A1C1CSC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08420"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06688"/>
    <dbReference type="eggNOG" id="ENOG502RQQG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF19">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="58534" checksum="F299CE72BBC82719" modified="2016-11-02" version="1">MTIDQLPIRLIVNEREYALIRRLISKSLSAQPGTTTKRSKVHDGELSSEIQYGGHKAAAFRSASRVFVVTYGTLKAVGAVLDRLATRTSQTATRSRKPLVASHLRMALSLSSLLFFHATLYRIFVRLRLQLLHEKVRSIKERYPRIYAVFTSRIAPAIGASLSGLALGICPADQLRMTVSIYVGCRALEIGYAAIEHTKLIQSKPSWVGSWILFALAQGQLLHALVFDRDCFPEAYRSFVIGYTPEYIQRPPPNLSVRVTWPAPDSIVDALAQMARLRWPPFVSPILHPKMANTLPASIDPIISPITSRAHPGIQNLSCALLHPSDPSCFLAYLRQMLLSFPEIAKFFTKYYGALALLRFKKVLEAPTASLNRLSESILRSTIAVAGSIGASWGTICLFQSIFPRAFLPKFRFFLGGLLGGLFQLFDRTEAGHANSLYAARMSVDSLWKVGIKHRWWKGIRGGDVWVFVASLALVNVVYDLGKSTPAGQDRALSLIRVLRGEVELGLREKPETSTEATMTEEKVTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSK8</accession>
    <name>A0A1C1CSK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-conjugating enzyme E2 S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08822</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSK8"/>
    <dbReference type="STRING" id="86049.A0A1C1CSK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08822"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06594"/>
    <dbReference type="eggNOG" id="KOG0423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000077">
        <property type="entry name" value="Ubiquitin conjugating enzyme E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="327" mass="35249" checksum="0388F8D2B6DC497B" modified="2016-11-02" version="1">MASLRRLAKDHASLQSALPPNYLFADVEDGSSLPDDLTQLVVLVTGADGTPYASGLWRLSLKIPVDYPKSPPKATFKTRIYHPNVDEKTGAVCLETLKRDWDPKLTLKDILVTISCLLIQPNPDSALNAAAGALIQEDYDAFSTQAQLMTRIHAPIPKHLLAAVEEAKRRGEDADHKPESKPTAGQATPEQDDMKENDASGLSESSTCPLAGSQTSIRSKRPLSELPLPEDNDAGSLFDTDSEPRRKSPRMTASGVSDRTTNSQAAATIKQGEKAPTVEEGEAEGNKVAAQQSCLPPYPSNVSGPVAVRKPLSTKRKGQPRIGIRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT12</accession>
    <name>A0A1C1CT12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="11">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="11">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="11">PHB:PPT</shortName>
            <shortName evidence="11">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">COQ2</name>
        <name evidence="13" type="ORF">CLCR_08686</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion inner membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
            <orientation evidence="2 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="11"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT12"/>
    <dbReference type="STRING" id="86049.A0A1C1CT12"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08686"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06465"/>
    <dbReference type="eggNOG" id="KOG1381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT51633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="399" mass="43643" checksum="4DFF7F81A464C86F" modified="2016-11-02" version="1">MLCTSRSLHSSATGKALRSLTRASAHRSTWTQQKKEVRLLTVLDRERRPTSRCFSNHNRHQSTSATPSPLTQDLPTIYKPPTTGVISKLPSSWIPYAELIRLDKPAGTYYLFLPCMFSTLLAAPMAMASPFQVVSTTALFFTGALIMRGAGCTINDLWDRNLDPHVERTKLRPIARKAITVEHAIVYLGAQLLTGLTLLLQFPLPCLYYGVPSLLLVTVYPLAKRVTHYPQFVLGLTFSWGAIMGFPALGIDLLSTPPALAAAASLYASCVAWTLNYDMIYAYMDIKDDAKAGIKSIAQAHEHNSKAALSVFSAAQIALLATAGYFAGAGPIFFVGSCGGGALALATMVRRVNLKDVKDCWWWFRKGAWITGGTISLGLVGDYLYRRSQEESKRAAISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT44</accession>
    <name>A0A1C1CT44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT44"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08636"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06438"/>
    <dbReference type="eggNOG" id="ENOG502SM8K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="419" mass="47729" checksum="5FDBD465D9FEEB5A" modified="2016-11-02" version="1">MPSPPYTAEPGNWFLRGVQSAVFYYVSCTPWVEFKHKRKRRREAREQAQERADVVVTQPGRVRQPAPFQTNEAWAEELMLGPGPPKGWKKDSLLAKLQSRVHKESPESFTPEPELLALQPQPTEASARPFADSTTETSSTSGAEEGNPNRARSAPSPTRPLRERRLSNAVDNIKESLRTSLHPPKWNWKRYDREDEILAGFTERVTRMWNRATSGMHREDAGDQEEQDEAPAHKRKRTLTNESERYDYYQARHPEVNDMHPPIVSQLPATRAEAAWMLLPPPSAAVMEARTRPAAEPEMRWPLCVIGRPVRDTEPKPSLAKTRSTEQDHSGGIGHFTGAEDEDHSLDSIDDPSEDESVQGSDIRRENQNPSRIKHLSDPIIRPPPIHPVSRIAGDLFVPKRRDSWQFHYVVPSNQPVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTA7</accession>
    <name>A0A1C1CTA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SET domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTA7"/>
    <dbReference type="STRING" id="86049.A0A1C1CTA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07975"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06377"/>
    <dbReference type="eggNOG" id="KOG1844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="274"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="691"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="883"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="791"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="917"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="982" mass="107578" checksum="A97BE3615D17ACEB" modified="2016-11-02" version="1">MTESSLLTTHPLPNHYPVTAAPSLASPLPNGSLSDNIQDEEEYTIKCICIYADDDGNTVYCPKCDTWQHIECYYHGKKVPDEHFCADCFPRDLDTKKATERQRRHREALEGGDRKVKRASSKSQKKKHKDIHATPEQVNGWHHDRHESVTTTRDGPPAKKPKTSHRTSGSIVSTNGETRKRAASTVQSYPSPSKSPQDLFRFPAIPTYTLDFLELYDRDEGNTNARDNEQTIQATNTLFAWRTDPSLVVSPGQQPTAKSPFVRLDQPLDQSTWPQVSVETIRKTDIEYDGRRPTWRFLRIQSPVKKNEVVGEVRGQVGMLEEYCQQKSSSNRWQELRHPDPFVFFHPHMDIYIDSRKSGTRFRYLRRSCRPNVTLKTFVSDNDETRHCFVASQDIPTGSELTTPWFLDQAMIAAEDSELGQNRRLDWVSRVLANFGDCACDAGAACLLAPFDRRFPSKSSEAAHKEKGKRKKPSKKNQTISPFSTGHATNSRAGSEPKVLDDEDQSDRRSTPDSSRSGGPSRDITPVNVAALDADPVLGNGLTARELRKIQMAEKAFAQREQEKKDQSSQAVHRKKKRTSGGSTLNTPNVNTSKQLGHQITSHPNTPSGQPSRLNDTALGSPPPPRAPACRGKSMDPPSKPQPRMPQPVYTSVAVQTDPEEHELALPPPTKRRKFSTPTQRLLRKLLADRERHGQHEPVPASPTSACMQQQAQAPPTSGDVDMKDASVRADNPVTDAATSPHAASDDTIPPHNPGATTYPLPSQAAHTHSTWRPPPTPKLNLSTLPPVPVFPSSATSASSSSTSATTPGVTTTATAQSPTLIASISASHPGLTPGVITPSPARKKLSLGDYMSRRLASTPSTEKSQTQVGLGTGEVELAKVATSPSESSLGTAEAATGVPRPGQQLALQPMAQESLPSRDLEDASMKDEGEEPEYSPPEPVEPAEDSPRLATGASVALPTSAQITIPAEVTNILHQLAQFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTG8</accession>
    <name>A0A1C1CTG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclear pore complex protein An-Nic96</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_07935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTG8"/>
    <dbReference type="STRING" id="86049.A0A1C1CTG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07935"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06341"/>
    <dbReference type="eggNOG" id="KOG2168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1918363at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="921"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="927"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="944"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1123" mass="122507" checksum="83AD766D62FBE73E" modified="2016-11-02" version="1">MSSLFGPPASASGPSGSSGLFGGLNLNPTTDAQGKRKSIFDPSTSQNTQSAPFAGLSATSSAAPSGGFFGTQSTAPAPTPFSIPTTTSTTTQSGGLFGTAPSATQQPALTLPPFGAQNTQQPATSSLFGSTTAQNTAAPAASQAPPGQAQNNGDAAYFSTLLERQKKKPKLTAEHNGRHELPSLSMDLGDLARRAQEIRHRGTKQPEPLSESRAHYLLAGSGVAPGQAYKDFQALGPDDAAPVSRVAAQSFADESSAYLRDLRVKGRDAMLRESMDRVYREVDSFIEESLGVDFEEQKVRIMEHFGLVPPEDGPTPAGGRQASGGFGKTTRRGKHEQSDLSRSARSVFGRSALEKSIIGIAGSGAGSASFFRSEGAPPTPAGLPRSSSQVLRELRNKEKVFIEKVQELSNARVKHDAYPLLQKFAETEEQNKADSPRQLVDAYQALREITREGSSELKQRQFADAYLDESSSTQAMLKLKKQILDGSRTYLERAFFREIKTKVEQNPREASLGGQPTVTNIIRAYIRLRVIRRDLAPDGTELQQLNGENGDYCWVLIFYLLRCGFVQEAADYVQNDPAFQSIERRFVSYLTGYAKDRDRRLGRKLQDMIDNEYQNRTKASPKNQVDPYRIACYKVIGRCDIGSRHLDVVGQGVEDWLWLQFNLARETERLEEISGEVFGLDQICETVTEIGQKHFQKSQVDGSNGYGTFFLMQVLAGMFEQAVDYLHSFNPLSAVHFAIALSYYGLLRVSDFSVAGIELLTFSTTQQPMINFVPLVAYHTGTFRTALPAAAVDYLSLLCLNSDLRPPSLGQVHTNACHECLRELCLETREFAKLLGDIRSDGTRLPGAIELRAKLIHLDSREEFLSSITRQSAAIADQRGQIADAVLLYHLCEDYDNVISVLNRALADAVTVDLGQAAMQLQPLKPRNSNGKSPGSSITEGGEPQSSLSLTQSTSSPFELGKNMVELYNQNAAYFNKISSSNREISGALLRLLIIREHMEANPPRYMTALEELNELGLLPLQAKGSIPIIRAAATAFGALPQIVARCAGVSVVWAVRAIGGERDRINREGRWEAGFGGDANEVKEQLGNMAKDLMVFAGLVKYKLPGRVYDMLTRAGADVGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUD6</accession>
    <name>A0A1C1CUD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09249"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="141" mass="15927" checksum="E03FAC785E735534" modified="2016-11-02" version="1">MYALLMKSVGMRRELDSYRSREERTQPRWKYVVHHGASGVGRRMRRMPSSHAAQHASQHQDRNGRDVVRILHPSISGYFTCARTGEGLPDSQLSKPWRRSALSMLGAESLTFPVERREMLRIGELGADVALTLGTFDCTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUT1</accession>
    <name>A0A1C1CUT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_08574</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="9"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUT1"/>
    <dbReference type="STRING" id="86049.A0A1C1CUT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08574"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05914"/>
    <dbReference type="eggNOG" id="KOG2877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101026">
        <property type="term" value="P:mitotic nuclear membrane biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000012">
        <property type="entry name" value="sn-1,2-diacylglycerol cholinephosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT52247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="407" mass="45824" checksum="855A060EDC2CF118" modified="2016-11-02" version="1">MVYIRQRNLKKLHEYKYSGVDKSLVSRYVLKPFYTNVVIKCFPMSMAPNLITLTGFSFVVINVLTLLWYNPTLDTDCPPWVYLTWSIGLFLYQTFDAVDGSQARRTHQSGPLGELFDHGVDACNTSLEVLVFAASMNLGQSWNTVLTLFGTILTFYIQTWEEYHTHTLTLGIVSGPVEGILTLVVVYFVTYLKGGASYWQQPMLPSLGLPKSGLIPPSLYQMAWNEWYMLYGGLVLVFNTASSIQNVIDARRSRGEDPFKAHRGLLPFIVTWLVIPAYLSLNPVILHHHLVPFVLLAGIINAYSVGQMIVAHLVKDRFPYQNVLVLPLAWAVVDSLGPKLGLWPSALGDDIYQVAFIFLSLGLALGVYGSFVHDVITTICDYLDIWCLTIKHPYVEDKQNEGAKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUU4</accession>
    <name>A0A1C1CUU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_11376</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUU4"/>
    <dbReference type="STRING" id="86049.A0A1C1CUU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11376"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05889"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="76"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT52276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="249" mass="27541" checksum="AFCB9DCE0B764DCB" modified="2016-11-02" version="1">MTALPYAVPPNYAIRLVEEPLFPASQASIHDHHHHPVQPHPSHPSHFEFPRTSLHAATLHAHFKGPHAPGSVRAPRSATAWSPPTDIRETLATYHIEIEVAGVTDKEAIVVQWLSPHTLLVQGVASRPANIGLTDQEEGKRIWEGKEGEGWATESGHAKKPEPTDGGPLMRTPSRETVEAEYLADTTPTILLSERKVGPWRRTFTLPEDVEMRELKARLEGGLLRIDLPKRSVEDLEAMKGGGVRIDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVD6</accession>
    <name>A0A1C1CVD6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_09572</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVD6"/>
    <dbReference type="STRING" id="86049.A0A1C1CVD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09572"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03869"/>
    <dbReference type="eggNOG" id="KOG4344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66546at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22572">
        <property type="entry name" value="GCP5_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059169">
        <property type="entry name" value="GCP5_N_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032797">
        <property type="entry name" value="Mod21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14609">
        <property type="entry name" value="GCP5-Mod21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-Tubulin ring complex non-core subunit mod21 N-terminal" evidence="8">
        <location>
            <begin position="65"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="221"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="552"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="786"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT52473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="906" mass="101009" checksum="B3768D4E60A80114" modified="2016-11-02" version="1">MASPTTMNNWLEALALTFIPPATSPTTVAKHKDSFTRRVKHHSYGRTNQFAVTEKLIGLEEKFQVLNRDDVAGELFSRRVELNRDHGDIKWLPDVLDLLLHLSIDPVKYSRVQDLEKSRPDSAVQPVLKWADIEAEDPIDQRDPIWQVPQYSDFSSDEEEEVVASSTQTSPASIKQRHAQKVDEASIFDAPTVEVASKLEAAQFWRTPGDYVTITEAQAAREVLFMFSGLPTSIFMRSDDGFKPSARYRVRHLESATSESLLKEAADIASEIQPIRQWLRGRQDTSIMQLIHSEISEMLADFERTISQEHTAILHQTSHAGVVSLLQVLQRVKRASLPLKALKTITPQLTKNDPVVVLNAIHNAVDIAQSSCNVVDVESLLPILLSALTLHAKSIDTWLHTGGIAKTKAFFIAENHKTPHQKSSLWHDWFSLTSNSTNVIPAFLKKFTAKMFTIGKTAAFLQHLDAVSLDDQVGDLGVAAAALEAANLIANSPLPFSATFEMILERHLTALLNSSTSMLKHILETSCGLTKVLDAFDYLYLGKDGVIVDAIENKMFNQIDHCLDMWNDRFLLRDLLAEAYNDINCVDAKAITIQTAYTSSRTMENRRRSVKILAAVSISYHLAWPLANIILPTSTACYQRIALTLSQVRRARHQLERRANFYIQHMPLIDNQTDTDLARLVYWQLLLFVNVLYAHLTSCVIQPLTSHMRERLRSASTNSLDDMISIHGRYISALEHACLSSKRMKPLRDSLISLLDLCVRFSDMITSAVTNTGIQAASRERHEGDFEASSFISAQSRRRRGGKNTSAGDFASSSDEDDDDDGVGEGYSTFVFDEDTSLGQEISKVRNEFKKHVGFLTAGTRAVARSSSTGVRATGATGEFEVGERFELLAESLEGAFSSTTRVGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVX2</accession>
    <name>A0A1C1CVX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Versicolorin B desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">stcL</name>
        <name evidence="9" type="ORF">CLCR_10040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVX2"/>
    <dbReference type="STRING" id="86049.A0A1C1CVX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10040"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04026"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT52639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="514" mass="58137" checksum="DC3BD9F74210D11A" modified="2016-11-02" version="1">MIALQTAIRALTLLVFALTVYVVIRIVYNLYFHPLREYPGPLAWRATRLTWVLALQRGCLHRDLLALHDKYGPVVRVAPDELSYVDPRAWKDIYIGKLSGSARLGHARAPIERNGIWFRKQRADEPEAIMSSNEEAHARFRRAFTGAFSEKAVRDQAPLIEKYVALMVQKFRAMADDGSRNDGAAVVDIVSWLNFVTFDISADLSFGESFGSTEQARPHPWVEIACRFGKGIALAASLNYFAPLQKVLRYTMPRAVREKMVYHRELSTRKVRQRLQLEGERADFVQAVLNYNTDREKSEGEKVTPQELELNMSVMVFAGSETSSTAMASVLFGLLNSQRAMTRVTAEVRSAFQHEEDIDVASVGGLEYLTAVINEGLRLGPPSAVTVPRIVPASGEEICGRWVPGGTFVTVNQYPAFRSAANFSNPNEYIPERFLPGETPSPSDNLAAFNPFLVGRHMCIGQRFAWAEMRLILARLLYAFDITWDVTPRIKDWGEQQTFIFWQKDPLFIRLKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVY0</accession>
    <name>A0A1C1CVY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVY0"/>
    <dbReference type="STRING" id="86049.A0A1C1CVY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10293"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03967"/>
    <dbReference type="eggNOG" id="ENOG502SSMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5339332at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="419" mass="45818" checksum="7DD53CCF1B64588D" modified="2016-11-02" version="1">MDARVDTLSGRFGGQWAFLSTPPTAGSRSVPHSSSYLRSDRSNISPLPTALHFHQLNASRSSLPRHAHATSVGDRSSTTTIPTHPVLVRVHSADPILQVRPTRRPARPRRRPKSGSMDLPAEEEFSIRGILAAIAEDIEDDVDAIAEILGRSRLVLADQHESHLPPQGEIRAISSPLQAVAEASASNERLAAAVDDVLILQEDASLVEGSHTGSAAYGLLERLQIVPATRRMRSEIPRTVASRPATASVRHYSAPPVLPVVPPAVEDMGVSTITPLPQSSRRLLQSHSDGDKLQDSQPRTTDAVVAETYLSAAANAVTISDPPVVSEAGRHYPLYSYDYSELFEGPMISPPPARMTFRERLQSFIPHIDLPSLVSWVQGHDTQVISAESQLREILHRQRYVRGPRSHQGEIVESPEMYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWB8</accession>
    <name>A0A1C1CWB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">img2</name>
        <name evidence="8" type="ORF">CLCR_10965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWB8"/>
    <dbReference type="STRING" id="86049.A0A1C1CWB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10965"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04188"/>
    <dbReference type="eggNOG" id="KOG4034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="146" mass="16092" checksum="3667B7FDB9C1331F" modified="2016-11-02" version="1">MTTTGQDSEDRAAKMYPDTDPSTPSPTVLAGDLKASSLKSRIRDFSIGPTLSSLPYSILRTPSKNLPIYQTTKSGGSKHITTIRKIQGDLTELATAVRQALGMEEYMTDPRGRKKANVVINRTTKHVIIRGWRGAEIKRWAEVSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWD1</accession>
    <name>A0A1C1CWD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">tbpA</name>
        <name evidence="15" type="ORF">CLCR_10175</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWD1"/>
    <dbReference type="STRING" id="86049.A0A1C1CWD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10175"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04190"/>
    <dbReference type="eggNOG" id="KOG0727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000020">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000049">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="216"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT52849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="439" mass="49094" checksum="357DF61BBB212015" modified="2016-11-02" version="1">MGDVLVDNPANIVPPHKKQPISDAIPEIDSLEGAGADANDDYATLKRLQRHLEYARLAPAVRRHSSLSDRYIKLQEEYIKDEQRSLKRELVRAQEEIKRIQSVPLVIGQFMEAIDQNTGIVQSSTGSNYVVRILSTLDREKLKPSSSVALHRHSNSLVDILPPEADSSIAMLGQDEKPDVTYADVGGLDMQKQEIREAVELPLTHFDLYKQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTTASFIRVVGSEFVQKYLGEGPRMVRDVFRMARENSPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTSNVKVIMATNRADTLDPALLRPGRLDRKIEFPSLRDRRERRLIFSTIASKMSLSPEVDLDSLIVRNDPLSGAIIAAIMQEAGLRAVRKNRYNIIQADLEDAYSSQVKGAQEADKFDFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWR0</accession>
    <name>A0A1C1CWR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">HAUS augmin-like complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_10517</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10517"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04333"/>
    <dbReference type="eggNOG" id="ENOG502S1U0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5372507at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25762">
        <property type="entry name" value="HAUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT52993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36275" checksum="C19F28BAF02331BD" modified="2016-11-02" version="1">MEASPSKARAQAIESQSWSIVLSWLSDLYHPSPVPAFERNATTLRAFQSLMAKNVAADRLQELLFDAKCEELAISQRDRMQRARGQGPTGHNATSLLPLLENSLSGAGKDSLESLARSAVLLGCCSPPSSSQSESIIDSLPARIVDLSRLTFRLEDHVSSVETLTSDLQAQTTETLHHLSAMRARVAQLSNPEDPADSRPSTPSHASSIGLTTTDYSQLHAQTLQHQRETKQLQLKSVEYKARIDALDRQLATTEGAAPSSSSGVTSTAALVSKQQDLEDKRKRITTLEARFRVFHGLPPDVDASRGEVNRLQAELEALKRRRDELFERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX53</accession>
    <name>A0A1C1CX53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX53"/>
    <dbReference type="STRING" id="86049.A0A1C1CX53"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11027"/>
    <dbReference type="OrthoDB" id="4136092at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="118" mass="12944" checksum="4E5E40344F66AFDA" modified="2016-11-02" version="1">MPDATSSADFEDETDIDVPPELAGNNHEHVCVGPYNKGHSLHISAAQHDSLEGAPSYAIATESTETCGSLGANHDSDIVYQRHWARADSRPDLLELPEALYSNTVDLHARRWLKDFCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXD8</accession>
    <name>A0A1C1CXD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bacterial alpha-L-rhamnosidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXD8"/>
    <dbReference type="STRING" id="86049.A0A1C1CXD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10669"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00168"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF6">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial alpha-L-rhamnosidase N-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase concanavalin-like" evidence="1">
        <location>
            <begin position="212"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="30880" checksum="D1008EB1EB5240E8" modified="2016-11-02" version="1">MKNDDGSLRPLHFSRSFELPRARSVRKARLYVTAQGCYHASINGQSVGDQCMAPGWQSYKYRMHYQVYDFEALLETNGANLITVDVAPGWFASVLAWVDGRRCLFGDELGLLAQLHVSFKDGDAKTFVLGTDGQWQCQCSRITSSEIYNGEVYDMTFESAPVTRGEAQSTNSRTNSQAVKVVSFDFAKLVSPNAPPVRVTEAVRPVSIFESASGKTIIDFGQNLFGWLQIFELRKRAGHVVRFRHAEVMENGELGVRPLRHAKATDTIICNGETLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXL7</accession>
    <name>A0A1C1CXL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Transcription initiation factor IIE, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXL7"/>
    <dbReference type="STRING" id="86049.A0A1C1CXL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10424"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00163"/>
    <dbReference type="eggNOG" id="KOG2593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor IIE subunit alpha N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="366" mass="41668" checksum="EE469AD6818DCA9A" modified="2016-11-02" version="1">MEAAKELLRTAVRTFFSHPKQILIIDAILLHSVLQMDDLNLLLQSQPKDIRALLNPLRNARLIATGARAEQKVTGARPSSREYYYCPFHPAIDAIKYKIAKLRKKVEALYQQDENTKRKDWRCPRCKAEYEELDILDKVNEDGFYCDRCGATLVQNEQAARTNMDRSNHEKIRKLNDQLKKFDAMILKIDRQDIPENDFQSAWDRRKYVPRPHGSGRQDTAETQYMTLNRPGLNVKKHGQPELVKSENLTVNLTTSEDQEREEAERRETRRKQLAQQNQLPDWITNTLHNNGNASASDLGEGGAVANGTAMAPSDDSGADDMDNEDEGDFEDVEVEAPAPVAGLKREHSVAFQDDSDDNEDFEDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYH4</accession>
    <name>A0A1C1CYH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA splicing factor RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10401"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00546"/>
    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37381" checksum="E540F55A5B6F39EA" modified="2016-11-02" version="1">MDEVPVFRGAKRRKFTRSREDTTPSSAQQPSASTSDEKAQRPDESNDNDQEEAGSRIPTLIRSRKHIRKPVTGVRFTNMEAVHHGNTSTELVRSDESEAKHIDITDRFVGSTGQAVNIDQHIFQPLPADDTEQDTTVSNNRSPTNEKKSPANPTAARQLAEVDLGTSAHHLNLARTQAALERVKAGQAPIEDDVKPSKPRRPRLGRDGKPMKPRPRKRRNSEDLARDALVEQFLHENKIDIYDTSTPEPANVTRREGEGGEVGDPDDDERFAERFRQEFMDAMAERRSRAKSATQTKGATATESRGPKLGGSRSARAKMAQMRQQQQQSGASSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYJ4</accession>
    <name>A0A1C1CYJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MAN1B1</name>
        <name evidence="11" type="ORF">CLCR_09909</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYJ4"/>
    <dbReference type="STRING" id="86049.A0A1C1CYJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09909"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00533"/>
    <dbReference type="eggNOG" id="KOG2431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF49">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT53572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="601" mass="68517" checksum="330DCE684D8A9ADE" modified="2016-11-02" version="1">MILIRRLWLVPAFLLACLVYYLFLYPSDTTAVPLSVLNPNHNLHWTKQPERHPVAGYRDLPIGPLQQIPNIQFDFASHPESADAAKTRETRRAAVKEAFLHSWNGYKKYAWGQDEVAPVSGAFRSSFGGWGATLVDTMDTLWIMGLKDDFDLCVEQVKRIDFTTNDQETLNVFETTIRYLGGLLAAYDLSDGKDRILLDKARDLGEMLYSAFDTPHRMPQSRWQWKKTALGAEIEPSTNTLLAELGSLTVEFTRLSQLTGDFRYFDAVQRIAEEMEYYQNATKIPGLWPTIVNAKEISFDYNHFTMGGMADSTYEYLPKQYMMLGGRDRKYKHMYEEAIDTAKRHLFFRPLVPSNKDLLFSGNAALTTLQSIPIASIEPQGQHLACFVAGMVGIGARIFSRPDDLDVAHRLVDGCVWAYDAMPSGLMPETFHLIACQVGTGAPSPPEKCVWSDDKWYEGIAKKHAVTQDTDRLTPLERGQKFAEQKGLFRGFTDHGDNRYILRPEAIESVFIMYRITGDPHYQDVAWTMFQAIDRATRTPIAHAAVHDVRTATPQKSDRMESFWLAETLKYFYLIFSEPELCSLDDWVLNTEAHPLRRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYZ0</accession>
    <name>A0A1C1CYZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10866"/>
    <dbReference type="OrthoDB" id="4153409at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="155" mass="17759" checksum="0209510E7C82BDE4" modified="2016-11-02" version="1">MCYIAPFILIYQCDLCPSTIRATISPLHICRFGHIHDPERASLHETETDIDTHNPNAVCDGTFTQMPDTGTPPCTLTVKSHERCRPCQARLGLEIMPGESEDEQEREMARTLLWSRWLEFIRGSETGRYLSERAAWEEGMSERESGRESGRESER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ03</accession>
    <name>A0A1C1CZ03_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ03"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ03"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10638"/>
    <dbReference type="OrthoDB" id="4500473at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="288" mass="31344" checksum="EEFA19D77B58E35F" modified="2016-11-02" version="1">MSSTKTYFLCPTSDFIYPPPTGPLCLGSIIRSTSAPQYPLNRASVVAVADAFPPVVETDWKKTFSTEKGLGLGVYAQFLQLATGGLPLGPELNVEHSSKTANTFAFDTLTTLAFEPTQEYVEEAVKAPAVQAWLREPRQKFALVSELFLVTGMKLVKGAKIKYSTSQSTTIKGNLGIDVTALGTTFGPKGHWTRTNDDATESNRESEFVFAFRVKRLKFGRKLKLEDYNKGAFMTVGGKKDDDECVLVEDVDGADIRTAEAVPDVTENGNVYCVPASSCSTNLGLQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ44</accession>
    <name>A0A1C1CZ44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ44"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ44"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10924"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00688"/>
    <dbReference type="eggNOG" id="ENOG502S8NQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249419at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07262">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF2">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="137" mass="14934" checksum="08A443D163A52605" modified="2016-11-02" version="1">MPLDHVSYSVHFSKFDAEVAFLLASFGHMGLKEFRRPAPGVVGLGEECQPWLWVCGIEDRQPIRDDVRVLKNHLALTAKDRAQVDTFHAAALKAGGTDNGAPGVRAEYHPNYYGAFVTSPGGHNIECVVHTPPPATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZA7</accession>
    <name>A0A1C1CZA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional lycopene cyclase/phytoene synthase</fullName>
            <ecNumber evidence="8">2.5.1.32</ecNumber>
            <ecNumber evidence="7">5.5.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CLCR_09779</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34475"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>all-trans-lycopene = gamma-carotene</text>
            <dbReference type="Rhea" id="RHEA:32219"/>
            <dbReference type="ChEBI" id="CHEBI:15948"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>gamma-carotene = all-trans-beta-carotene</text>
            <dbReference type="Rhea" id="RHEA:32239"/>
            <dbReference type="ChEBI" id="CHEBI:17579"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carotenoid biosynthesis; beta-carotene biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the lycopene beta-cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.32" evidence="8"/>
    <dbReference type="EC" id="5.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZA7"/>
    <dbReference type="STRING" id="86049.A0A1C1CZA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09779"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00794"/>
    <dbReference type="eggNOG" id="ENOG502R13G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="UniPathway" id="UPA00799">
        <property type="reaction ID" value="UER00773"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00802"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480">
        <property type="entry name" value="BIFUNCTIONAL LYCOPENE CYCLASE/PHYTOENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCT53874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="599" mass="67467" checksum="F9E497812B0E6EDA" modified="2016-11-02" version="1">MYDYAIVHLVYTVPLATALSIILGPLLTRRDIYKICFLQIVAVSYTIPWDSYLIRNRIWTYPEDVIIGPTLLDIPAEEVFFFHVQTYITTCLQIVLNKSVLVATYLHNEADPRDPVGRSLLLGKRAGQLVLALLALGPILLRDGPKEGQYLRLILAWACPVMYMLWTFGYQLLLTLPWTKTWLPIAAPTLYLWIVDTLALRRGTWSIELGTKLGIHIWPHLEIEEAVFFLLTNTLIVWGSTAFDNAMAILDAFPEHFAVVPGTPSPILMFKALFLPTSKYDTARLEGLQNALTVLAKKSRSFYLASGVFAGRLRIDLILLYAFCRVADDLIDDAPSVEEADKWVQHFTCFLDAAYSSKRDPGRLQASLEPFPPKAQSILVLLPTDKLPPGPLYSLLDGFRMDMKFFSKGSKDEPPIQAFADLERYASCVAGTIGELCLNLVYYHDPDGGTQDEVKHKCLAAGFQMGQALQYVNIVRDVKSDAVVGRCYIPHEWFDKSAETSSKAQAAEILGFRRQILDTAFKIYAENRDAIESLPYYARGGIRVAVESYMEIGRVMRERMRRGQPLDFAGSGKKGRASVPKSRRIRVGWWTMMGWRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D074</accession>
    <name>A0A1C1D074_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_00163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D074"/>
    <dbReference type="STRING" id="86049.A0A1C1D074"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00163"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02593"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="8">
        <location>
            <begin position="579"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="643"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="727" mass="81131" checksum="1327929E33D37D36" modified="2016-11-02" version="1">MDDNAHAACYIFKPATQEDGDINPRPPKRRRLVKATSKTLEEDARWPRLLGGLESQESVKLRKSLFESTWATQQAKLDKTGHPVDEELVEDVLNYRGRGETASQSAQESLPTHLLVASATTQHEFQQALQRRMQETSDTNDVWVSLQPTHCSNLQTALKAIIKASIAGRRGEEAYADFLAENKALIPMNFDLELLYRYVQQQNAERVLISVTDVETFDTSVLSELVSTFHSWSDRIPFMLFIGISTTAELFESRFSRATINLLDAHFVETKPFGGAESTLFNMYETLQHDTTTHIFLGSSIVNVLAELAGAQSTTPDTLVRALKYAYMSHFFANPLATLTAQLKTHVQWDPALCDAIRNLPTFKNRCEALAQGDRAQRQKARQLLASNESLWTEAKAAIQAGQEYMSSCLGAIRTLRHLYHSKLHIRTDKNTPWETESDLLASLPDLTRSDTFKAIEDTLKVRRITSLSEMLDGEVEAEREPEPAPKEKTKTNRLNDLQNYLSETGTLVDQETAAATAFLRGYLRHRTSISPSCSSSSSSSSSSSPLQPGVSPFRQFLAEAYTMAHRSPLSQIVHPRPRHCIERALARPADYLGCSCCAGGGIADAATRTTATLPPTSVLVQMLNEAGAVINVRDLWDAFRDTLSPPPTRRGSGEEEEEESVRDEEDEEDEEDEDGAGTGTKARRTERQVLALFYRALAELRYLGLIKQSKRKPGVECIQKTVWMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D096</accession>
    <name>A0A1C1D096_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase II Elongator complex associated protein Kti12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_00254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D096"/>
    <dbReference type="STRING" id="86049.A0A1C1D096"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00254"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10161"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="469"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT54233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="60082" checksum="95723F7C33CEE270" modified="2016-11-02" version="1">MPLIIVTGLPCSGKTHRAQQIAASLTEFISSSADPTVSKRTVQVIPSQHALFDPGAGPHSGRGVGSETAQEASSLRDQIYTSAAEEKNARAAEFSAVKRALGRDNVVVADALNYIKGYRYQLWCEAKAVGTRCCVVHVAAREDECAAWNAERAMAWGIKSETDRGRPDAEAGADGEHGRHEQGLQKHGENVLGELIPESHTAIYGDRGVRETGPSRSPSSSLDGVEGDASRARQPHDETMTLKSLYIGERDDTAPATGIRQPQASISSSSASASPSRGVALPIPLSTAPPPPSTASPPYSPSTLASLCMRYEPPSPFSRWDTPLFVVPSTDMAPPMQDIWTAIYPPPTRPTSKKALSQLGPQSPFKPSTPATNGNGAEGIGRGNAGSSPSANPPATKAEDTQPGVSGVKPHAATVLPRATGADALQTLESATMEVVKQLLAQTRAQSPAILQGEGGEVDLRVPVHVRGQNRAKNSTATAEEEEEEEREAEGEEAADAEANADASAVHMTLRVPPGVNLTQPMLQRLRRKYTQIQRGGIAHGQGYVVGRRAVVESFVRFLADEWDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0F3</accession>
    <name>A0A1C1D0F3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0F3"/>
    <dbReference type="STRING" id="86049.A0A1C1D0F3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00912"/>
    <dbReference type="OrthoDB" id="5400850at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470">
        <property type="entry name" value="VAST DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="7"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="304" mass="34782" checksum="C9DCC742CD237C87" modified="2016-11-02" version="1">MFSNECFEETCEAIRNKNEARVIRDISLLIVASAEVLAIRGNQHCRLLIESVNEGWNNSIPLTKPRPQPDYSVGFRREAFTETQLRKLQPFVGDLTDNSFFMGTWYMYFPFFSSEVKCGAAALDVADRQNAHSMTLAVRGVVELFRLVKREEELHREILAFSISHDHRSVRIYGHYPVIEGKKTTFYRHPIHEFSFTALDGKEKWTAYKFTKSVYDTWMPAHFKKLCSAIDAIPPDIHFEVSEESELQFPSSSGLSQGLESHHLSDSGATGDDELRLLDPQEVTPETSITQPSEQATFKKPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0U4</accession>
    <name>A0A1C1D0U4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0U4"/>
    <dbReference type="STRING" id="86049.A0A1C1D0U4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00307"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10208"/>
    <dbReference type="eggNOG" id="ENOG502SFC0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5278907at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="269" mass="30006" checksum="AB8BBD08E0C40FAD" modified="2016-11-02" version="1">MAVPTRASRALTFMHHCRCRRSPSSLHQPRPQTQRHASTEATPSPLSLSPYAPSNFTRPPTAAAPAAPSSPDLLADDSGLSAASTLPAPRPVYAHPISRPPPPTEIPGTRLTFTSWALSLVGIAPKPAATYTPAPFRVTNNPYRARKRWPPDFRTLDPKQQFHFEKTYRRRAALKWARPRWNKGVKLVQQTLITFTIIYFVFICEPGHGMGTPFDGFRVWFFDKVGRLGQLPESTREEAEKLSDEARQKMRRQQADTTARAANTPVAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D140</accession>
    <name>A0A1C1D140_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome segregation protein Spc105</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D140"/>
    <dbReference type="STRING" id="86049.A0A1C1D140"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00752"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01665"/>
    <dbReference type="eggNOG" id="ENOG502S20P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5592879at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040850">
        <property type="entry name" value="Knl1_RWD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033338">
        <property type="entry name" value="Spc105/Spc7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18210">
        <property type="entry name" value="Knl1_RWD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15402">
        <property type="entry name" value="MELT_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01315">
        <property type="entry name" value="Spc7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spc7 kinetochore protein" evidence="3">
        <location>
            <begin position="1101"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="822"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="978"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1434"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1639"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1701"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1277"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="712"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="774"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="983"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1648"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1707"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1726"/>
            <end position="1742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT54398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1787" mass="195690" checksum="037D7E0A533FFB6E" modified="2016-11-02" version="1">MADSSTSPRTSRPKSRQSIALMPSTRGSASRDNATTDIAALKAQDAEARVAKRKQRGKSLGPGGLEALRESSGNTTKTTTPFQIKSILKPTIPLTPPKAIPTFDELRKRSTGKGKSPTKSAAEELLIDFSTPGPSRQDSKEVSLSGAENVADPFSPMARRSPRKSNAGEQGAGALELEQEEERQRQAEKAAILERRAARRKSMANRRVSFAPEATLHTWSVMELVEDSTTSSASNSTRRQSSITPQQSPDKSLRSPDRVQTPATPTAQNEEDVVKESPANQRDLHQKKRRRRSSGLAEPMLDATDESVYSSSPSGDVATNSSPMRVEEGIESSDESDTDGDTAMSMDESTVHSTNSEESASSSHSSLDDRLRQAANQAGTRGIEHDEYGDDLPMEMATGTITSAFQPWTLNRAAENDNITVHDQENVYPVLPSLPADEGDDVEIEDDDEEESHEMSMDVTSAVGGIVSSLSPEQHVAKSRRKSGIRRRRSSVNESVMDETMEFTVMQGGIIGARGDNTTNSRASDEDISMEFTHAAGGVLDAASRQESLQSDVVDENTAMDMTAAVGGILPPIDEQTEPQTDVEDQTMAMETTRAVGGILFNNQRSKRQSLPDQTQNLPRADVDQDQTMTMDMTRAMGSILPSDRRARQFLTGETIPSPQAMPEPEGDDQDQTMAMDMTRAVGVILPGGQQATDMPPPNELATAPSPRPRTTEQTTLRSTPRFQHHRTSIASETGSPSLSLKPRSSARSQRSASKQSTTPHGKVHDTTPVKATAQAQRGTPSKQITPIPTKPESPNKTPLSANVVHRGASPKKLFKAEIKARASPASTKRNHLFSPGSQTPSIVLKATRPSIARRRSSGIGIDKNGIGSPRVTELLDRRSSIGDAAPHFKLVSIEPDKMRSEDPRQIAQEVEAERAEEHRRESGRLIMEQEVDEPQEENTTATLKDMIESMTPQKPKGNKIKGRKSFAVGAAKGLLGKRPAELDMDDDDEADSTPKRLRVVSRESSPVKQIRLPKPPSKDETTGRLGAKLQKSLQDMANTDNITPTLRVASPTKNTVPQSPAHTGRFRDVEASADARPESFEDKLDNVMGAIDISTAQMDVGAAKFHEEKISLQQFLNMTNIHFIELSTTKRRHTMAQSMPARPSQEGMGGSSTEASFVAAATTLPLLELYQHATRELKTYIYTGRKIIRSIEAETLAEQPALFREYVDARPDVKVIMDNQFRHGKAHARLQSKEGWYQWRTQLVDGLKTGLQGIDEGMKADLELLQQQQQTLDDVLPVLHQERAELENQKSSLEQSLKELDSVDHEVLNDCRRQLQNADEYFLQRSALLDSLQEQMKEKEEALRAADELKSEMKDQIAEADRVREEHKGWPVSDVFALKSRVEAIEKQTGWRLVSAEEEVDEPTDLGAALVMTYKDELRLFFYPQSFQCKVTDAPRRRSGRRSASSSGPTAPISLTYAPTNLEDPDASAPELPTEKRFFLQLIRSQLHAYAMMPKRSVASKTVLATVSDGWSLACKVSEELRLLNFIGISTATILSDEKLGLKVMVMNSKQGRIDIEFAVSVTILSDGNIVTSTNVTASAMYGFAVELISGSKGRKVQHALSKEVESRTLGEGAFLQAVQGFEEWLYGQEKAKQEAKKEAKAEAKAEAVTPAPATAPADAAPQSSSAPTSTTPARHPLAPKRANAIQKRALPIPKQRLEKGSQQLSQPNQHAQSQAQSQAEKENFNPTVSVLGKLNSQQDSNGGGGGGDWEEMATKAAMPPDVQEQLYQMHTPIKRVGALRRSPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1D8</accession>
    <name>A0A1C1D1D8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_00894</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1D8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00894"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10105"/>
    <dbReference type="eggNOG" id="ENOG502SNHP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF166">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="46"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="353" mass="39646" checksum="6325E4EA3ADA700F" modified="2016-11-02" version="1">MRSQITNDEAKTANWVSIGLAIVILLVRFICGQHYRTSSLDITTGVVLASIAILIARIVISNYVLEYGTADDVLLAGVIHYESLDLDQIKTGTILSLISRLLITTVYWLQCVLLLRFYTRILAHIHWVKLCVRVTWVVIGASYIAVVFATFLECRPFRVYWQIQPDPGSCVQAYVQLFVQCVCNIIIDLLLLAISYPVLRTRGHKWSQKCRIALLYVLGSFCIIITCIRVAYIHGSNSAQPARSFWASVQGVISTFVANTPSIYGQLKLKLREKTQSSEGRRRGDTQPDTYVLMDEMNRRVSRPPGEDVEEVASNPTVGSGSLKQRKGEDKSFWVSEAEIPQPDCIGKETNHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1E6</accession>
    <name>A0A1C1D1E6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcriptional regulatory protein pro-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_00792</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1E6"/>
    <dbReference type="STRING" id="86049.A0A1C1D1E6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00792"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10121"/>
    <dbReference type="eggNOG" id="ENOG502RX7Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5294180at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF12">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="682" mass="76051" checksum="1D8670322D92A97E" modified="2016-11-02" version="1">MASANEKKAAPPMTKDSPSTKSSKMHRRSRSGCFTCRLRRKKCDEGKPKCKACRHLGLDCEYKRPQWWSNNETRRKQKEHIKTIIKKTKTNEKNASAQSQYGMNHAAQGYSDDSQDEYDPTFDPSFATTPGLFDPYAPNIYMPHDPYGAVVPWEVDVKTERHTYVNDELTRRDSSISTFSTFYPPPAHATLPSYTGDDWVQHDGLESRQNSWTEGDFDFNALDVPHIAHHFEPQCSMVQLEDCDRPLFEHLLQNVLPMLFPVQEAYQHGSVRTNVMFPALENNKAYLHSCLLAAATHMKGNKLFFSPTAEDDAMRHKLAFVSIVVDALNNDSCHTEMLDALLGMISLQGCVGSAIDLEKELIPWHQHFQTAGDIVQRLNLPQTLESNAGTGVPPTFNMSLTAWIDILGSTMLGKAPRFSNTYRNMFFAQASTGLEKLMGCNDFVMYLLSEVACLDSLKVEGKLDDIGVCNHITSLATTLDSVEPQELLQFPFNKAGVLRPKQLTKNISAIFRKATRVYLCSLVPEYNRYQPATVNLIAQMAEMLQYVPSGPNGFDRCLVWPMLICGANSIPASPLRRVLSERCDALGDSADHGSFGRMIRLLHEVWRRNDDMVISAGVCEATPVTAGSPSGSISTPIASASILATAGTSTAASSSTTTTMPRNQNVHWRDVMQQNGWDFLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1S0</accession>
    <name>A0A1C1D1S0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">prephenate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_02976</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1S0"/>
    <dbReference type="STRING" id="86049.A0A1C1D1S0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02976"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04746"/>
    <dbReference type="eggNOG" id="KOG2797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="319"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT54640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="416" mass="45370" checksum="2351A127F8CDB19A" modified="2016-11-02" version="1">MSQPGGSSSSNSSKTLHVAYLGPEASFSHQAAIEVFPPSTDQAVTLHPLPSFSAIFSAIQNLSGPGDGTGSEGQSPARPRSRREPEDSIHYDYALVPIENSTNGSVVQVLDLIAQCGPDAPALYPDLEVCAEYYLPVHHCLFVSPRASSSAEHALGNTTASAATSHDDGNLQLRRAIRTLYTHPQVWGQCARFLAKHFSPKDVERIDVGSTSAAAQLVARDAHSATSGGLNAAIASKLAGERHALVCLAENIEDEPGRNTTRFVVVRNRRARQARRSRNIDDDDDTTDTDTVNFETPKLVATEVRQSQKQRPRRYKSLITFTIPHTKPGALADALAVFKNCGFNLTSIDTRPSRKRNWQYVFFVECEDASTPAAGTEGEDKVMEMLDELSKFTESLRYLGRFVDRLPEQDGDGRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1Z3</accession>
    <name>A0A1C1D1Z3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_02797</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1Z3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02797"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04876"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2587356at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06179">
        <property type="entry name" value="MFS_TRI12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053791">
        <property type="entry name" value="MFS_Tri12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="46"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="579"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT54782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="611" mass="65851" checksum="DC6783D9E10EBC41" modified="2016-11-02" version="1">MSDTEKPQAMAHEKPLAEDAYLEDDPHRAALEDNPDRPEKLTWGTVLSIFFLGLAFVGPVSGGFLLITAILFQIGTELGDVSNIAWMPGGWSIASSVSFSIAGSLSDIFGRRYVTLSGQLFAVVGAIVGATAQTTTTVVVACTLLGFATGIIFVAYAGIPELLPNKWRNVGLAWTEGAMAIPWAICGVIIANELVSKASWRWCFYIAIIYAVISFVGTALVYFPPSRPRRDYEKTRWQEIKEIDYMGIILYTSGLTVFLVGLTWAGTPAHPWKSASVIAPIVIGVLVFIACFVYDFTVPKQPFFPLDLFRRYREFTVLLVVVFVAGMIFYSMSGILPQGTLYMFESDGIQIGLTQLPNGIGNFVGGTLMPAIAHKIKHLKMQMIVALTIQLVFVALYSVAVPQNKAAWMAFQFFGQGCFGMITLLCYFIAGLHVPLRELGIASGLIGTFRSAGGSVGNAIFNTILTSVVTVEMPKRVTAAALAAGFPPADLEQLIPAVVGAATGVPNAFGAVEGATPEVQAATLAAFRAAYGYAFKRVFWATIPFGVIAIIAACFVLDSSQYLTNHTAVRMEKDTVGGATARTGHHQHQHQHQRGGDVETREEAGEGVSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D231</accession>
    <name>A0A1C1D231_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D231"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02989"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04848"/>
    <dbReference type="eggNOG" id="ENOG502S0NF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5552418at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="379" mass="41922" checksum="5617CD4DAB487140" modified="2016-11-02" version="1">MDGNDRRRSQYGPPYPPQAPARPLPGQAMGPPSTDRFAHPTTPARTDIGRSSMARPYLSGYSGYGYQEQPYGGSQMQSSSPMQGVEMQYSPAFMSEASRQQQVQASPQQQQQYAQYAPSSMLPPVGPQALYENMAYQPSQTAIDVMSSRFAVPQYMTPGEHPGATLGSAPAQYMTSQPEQSSYSHVAVSRPSMPQSYGAPQVDFPMAEPREVEEGAEPNRVQEALDEDLRNYHRQLRTVFDAIIAGRVTAAREKLLAASRWLVSSVAALGLHHDDETRHAERIDLWQEFNLAWEALGQKQKEITEEALRTRREPPDILSATSITSLMDEFVAMCDQLEQYGLVDFEMGAWEEQITHIFIACLDLLPPSDPSPDTGAGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D234</accession>
    <name>A0A1C1D234_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCD97-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D234"/>
    <dbReference type="STRING" id="86049.A0A1C1D234"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03108"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05055"/>
    <dbReference type="eggNOG" id="ENOG502SFGZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="333176at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018613">
        <property type="entry name" value="Ccdc97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="37"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="128"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="225" mass="25706" checksum="91464AEC6AE7E3D3" modified="2016-11-02" version="1">MPLFAEGTGVPLTLSNASSAAPPSAESQVPPRIRIKNRRKTYLDRHPEYFGPQLELADPLLYDRLVRRFQTAEEREAEGRRKGYSGILEADLYRSEAKLEALHHPDPNALFTYRRGPDGEILAEEKDEVPTNKEEGLDRWKWEMEARFLRGGDDDFDYDAVDQNSEYDDRVVEERDAQDRYFDEETPHFVEGEGEGEGEGGDGRRRSGSDSRPHDLKGETGVQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D294</accession>
    <name>A0A1C1D294_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative GTP cyclohydrolase URC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">URC1</name>
        <name evidence="8" type="ORF">CLCR_02896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D294"/>
    <dbReference type="STRING" id="86049.A0A1C1D294"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02896"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04900"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="7">
        <location>
            <begin position="113"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="6">
        <location>
            <begin position="346"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="527" mass="57847" checksum="3C39667C305556EB" modified="2016-11-02" version="1">MAASSQPPTNGVTTELVLSEILSTLKTMQADHANLAASVEALQSKVDTSHSISQLRPAPGQRTSNRDSRDSPSLDPIQLSKSATGAASPPTDATLRAPSSPTSGARKSSITSRIILTTYPGQSGIDPIPMEWGDPDPAKRGPIVVSRHHNTIRRRNAIGAHGGSYSIYHALAVASHNLNLEHKPDFTNTEPAATIGPFPAWGDKKKIVAMDPFGHLAPWLYKDLIQSQDVDIRPTIAVTKAHMKIPELEQSVKAGRLRPDGRICLNDTGELNVTKFAVEPVWYLPGVAERFGIEESALRRALFEHTGGSYPELVTRNDIKVFMPPIGGLTVYCFGDPAKMADPNVRLALRVHDECNGSDVFGSDICTCRPYLIFGIEEAVKEAQRGGSGVVIYFRKEGRALGEVTKYLVYNARKRGADRASEYFKRTENIAGVKDMRFQALMPDILHWLGITKIDRMLSMSNMKHDAIVEQGIPILERVPIPDEMIPEDSRVEIDAKIHAGYFTTGKVMSMDELNAVQGRSWDDIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2H2</accession>
    <name>A0A1C1D2H2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor RfeG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2H2"/>
    <dbReference type="STRING" id="86049.A0A1C1D2H2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02935"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05172"/>
    <dbReference type="eggNOG" id="ENOG502SQKQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4146887at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609:SF1">
        <property type="entry name" value="RFEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609">
        <property type="entry name" value="RFEG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT55083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="50181" checksum="5524D77C95153426" modified="2016-11-02" version="1">MSSRYVDDRDYRSTTDSRRRAERDPRERIESTRDRRIDERPLDRSRDTQMTDAMDIAIDRRVDPRLDPRMDPRIDIGRDTARANTASRIDPPRPDRVVDSRSAEPIEKYVQDPTTGQLYRQVPARAPYPRGDDRDYVDPPPPRSRTSVDPPASRSRTAVDTPMRDDRIRDEPRTGLGDYWCPGEGIEREVLQHEICKFLGQDATCRPGQDSRGRPGFWVRAYRPFTTAMEQTLREESERWLREKERRRRHGEPRGMPRSESPTFGSKICPGSYEQLAQQETQTARRYPGDMDLDDDDYRQPPPIRHRDPRDPRDPRDRDLEPPRPMASGRIPVSSAYPPEPGYPAQYAISSQQPGYPPGQSQYYGTEREPRTFNGGNTTPPSAISRASQSGGYGQPGYSSRSAPPVSQSIPAPYDPRSRDIMSGAYSSGYPESRPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D335</accession>
    <name>A0A1C1D335_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pumilio homology domain family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_02749</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PUF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D335"/>
    <dbReference type="STRING" id="86049.A0A1C1D335"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02749"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05189"/>
    <dbReference type="eggNOG" id="KOG1488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PUM-HD" evidence="12">
        <location>
            <begin position="519"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="541"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="577"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="613"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="683"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="724"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="760"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="343"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="867"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="875"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT55100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="907" mass="100581" checksum="422A6624E8C9D64C" modified="2016-11-02" version="1">MTMMEGGTTLEAVSIPPLVKGGGADQAIQTRGGRIQAYERRLSTKADYDLGKNAWNASSRIWGTSKSFLDGAVDDDPMRPTPVRQGSLSNYAQTKTVTSSLRTPTDINNENVPQSKMSWSSMSSSISFSTRQKGQPLSPTKQRQNQILEFVAHASNGTDEQPSLFAGSDPDVDDIPDAHQAQNHRRALAAAGSRAIPSPSRAASFGSNQLDPQIQAFNSSSFRHNGAFSAVQENENGHDRIGRSITHVNGTSDMSPYLEGHGSYIPMNGMSSETLHQHGPRSPIHGKFNSRLVNFEHVDQYPPAGNQDYDDILKSYGAMTLDQATVGAFPPRMPIHQSQFQRGISQSSAHHDHLDSTFHPANPRVQDVGSRLNPQAPPHQYGGFQYAGRGSLPPLTNDHRSNLNSPYYSAAGTPPTGPQSVRSTPGSGVSSRTSHHDQFVLDRKYAGPDQYGFDQSLFGPTSVPPPAITAYQYDAQTSGQPLRMNPLAHPYVSPGHPSMHNYPTGPRMPIRELEQPHIVRSPLLEDFRLNSKNNRKFELKDIYGYVVEFSGDQHGSRFIQQKLETANSDEKEQVFKEIQPNLLQLMTDVFGNYVIQKMFEHGNQTQKKILAHHMKGHVLHLSMQMYGCRVVQKAFEHVLTDQQASLVKELDGPNMQILKVVRDQNGNHVVQKAIERIPGEHIQFIVDAHRGQMAKMSTHQYGCRVVQRMLEYCQPPAKRVILDELLEHIHPLISDSYGNYVVQHIIQNGEPRDRRQVVDIILSQLLGFSKHKFASNIVEKSIDCADEDQREQILRGLTAPNDQGVTPVLGLMRDQYGNYVLQKVFNQLQGAKLVALRADMEHSYPMLRRTSYGKQVIAIEKLLFGNNGPPPLPPTSTTSSRSSIPPSTNPSSNADSEAPSLHQTDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C679</accession>
    <name>A0A1C1C679_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1446 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C679"/>
    <dbReference type="STRING" id="86049.A0A1C1C679"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00093"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07340"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF2">
        <property type="entry name" value="DUF1446 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11420)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="3">
        <location>
            <begin position="497"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="608" mass="66788" checksum="7297AEDC6D81A866" modified="2016-11-02" version="1">MGSLGPCRPVRIMNISGSPCDKRDAMAKAAAMEEHVDVLVGDWMSELNMPTLAYNAARGVGVGYETTFLEALEPALDNIAKKGLKVATNAGAVATKDLFDATVKMVEQKGLTLTVAWVEGDVVWNGVRDDLRQNAAKYFHISTGQCLKDWNHEPLFAQCYLGGMGIAQAFASGADIVVCGRVADASPIVGAAAWWHGWSRTDYDELAHSLIAGHLIECSVYVCGGNFTAWKRLDWAGINNFGYPIAEIAADGGVIITKPEGTGGQVAVETCKEQLLYEIQGKYYLNCDVTAVIDQAVLTEEATNRVRLSGISGRPPPATTKMGVTAFGGYQAEIHWAMVGLDIDERVKLLETQVRHSFGEERLSKLSNWHITAYGTAPENPRSQNAATVDVRLFAQARNEEDLSEWNFARPALDVNMHTYPAATFHTDLRTAAPKPFTEYFPTLIPQPTLTVHFSREELKPITVSPPSETIPHPAAQPSWETSDPVDLTSFGPTTRVPLGRVVFARAGDKGSNCNVGFFSREASEWPWLRSLLSTEKFKELMGPEFHGQKIDRMEFPNLWAVHFLIHDHLDRGVTANATYDVLGKFIAEYIRAKHVDMPAMFLAKGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6B9</accession>
    <name>A0A1C1C6B9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6B9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00127"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02036"/>
    <dbReference type="eggNOG" id="ENOG502T5B9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4152391at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="276" mass="30089" checksum="CAF5EE23821104B6" modified="2016-11-02" version="1">MASGRSAFASPDPASRGLLDRRPSSDQPRTNQPTLSRSSSNASGTSRKSEPGWLTAMNGVDRSRAGSAPENSTGKSHSGFSKLFGKKKEKKDTEHNIITSRHAVAVKTKLALDPKFKNVRRGSAPAYVSSATQNNLLISAGAQEMRHPHSGPPALYSPKEKAGLPMLTRIISGDEADELDEWEKMRDEWKQRKLPTLDDNIVEGVAVGGRDSGQSTPEEQDGKTIEIPPSEVVERQGVRILSVVGMTADEYSPRPSRAHTPIGGRWKKDEKGVWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6F9</accession>
    <name>A0A1C1C6F9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4 13">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">GPD2</name>
        <name evidence="18" type="ORF">CLCR_11193</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="4 13"/>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6F9"/>
    <dbReference type="STRING" id="86049.A0A1C1C6F9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11193"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01038"/>
    <dbReference type="eggNOG" id="KOG0042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="16">
        <location>
            <begin position="126"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="17">
        <location>
            <begin position="542"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT44100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="745" mass="81447" checksum="D30DB2FBB445299E" modified="2016-11-02" version="1">MASTGRIFSARRLIRPLLYSSAALAGVGGTIFYLSYRPINVPGSQGAIVPIPRTEDGTIIPPTFPLIKSRAEQISDLRKSGGLVGGPSQIPITQQLRNSFDRLRGATSDERERTLPADQAAGEPYDLLVIGGGATGSGIALDAATRGLKVALVERDDFAAGTSSKSTKLVHGGVRYLEKAVWELDYNQYSLVKEALRERKYFLDTAPHLSTWLPIMIPLQKWWQAPYFWAGTKMYDWLAGSEGIETSYFLTKSKALDAFPMLKKENLVGALVYYDGAHNDSRMNVSIAATAALYGATVVNHMEVTSLTKDESGRLNGAVVRDVIADKDGKPTTPITIRAKGVINATGPFCDSIRKMDDHTVQEIVAPSSGVHVVLPGYYSPQKNSMGLIDPSTSDGRVIFFLPWQGNTIAGTTDAACSITQHPIAGEDEIGWILNEIKGYLSPDINVRRGDVLAAWSGIRPLVKDPKAKNTESLVRNHLVTVSPSGLLTCAGGKWTTYRQMAEDAVDEAIKQFTLQTSPSTTPTRISGTEKIDDAAPLDGSCQTHQVRLVGAHGFSKTLFINLIQHFGIETEVAKHLAESYGDRAWTVAALSSPTDERFPVRGKRISALYPFIDGEVRYAVRHEFAQRAVDVLARRTRLAFLNAQAALEALPKVIDLMAEELKWDNKRKDLEWRESVSFLASMGLPKSKLGVSRRDVETGKAGFTDEYERKLYSRYDGPADTLESDSKLMSGHNPVIGTESPANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6P2</accession>
    <name>A0A1C1C6P2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cytosolic non-specific dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_00558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6P2"/>
    <dbReference type="STRING" id="86049.A0A1C1C6P2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00558"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01073"/>
    <dbReference type="eggNOG" id="KOG2276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037237">
        <property type="entry name" value="Peptidase_WD_repeats_DUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="829"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="844"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="956" mass="103705" checksum="8E6207CC2872A0C7" modified="2016-11-02" version="1">MCQIGESGSRTRPIPTPIRHEKRTGLLDSNPPLSRAPQALDDSDEDTTSDAEEPSSTSVPSNCVKHPIHRVNAPGSVQAVAIDDDVLFAGTQGGNIVVWSLETYELIASVAAHKESVLSLVLSEDKTLLFSSGADSIVNIWSTQSLQRLYSLYSHFDIGDVFCSAHSLRTQTLFWGAQNASIQWYRISTETGLKSPVIFSPGSRKHRFFDSLGPGGITNAVSDEDGPNSDLGGRVLTIPSQDYLPYAHKSYIYSVLLVKGICAHDKDEEVLITGGGDGTIKLWKIDNLSSCGPTQITKFKTPDLSVLSLSYRGLFLYAGLSDGTANIYNLASNQLVQRLQVGHGDVSQIILSTDSIWCGTSEGWIKVRNLNHGQGSGLTPGQRYNDHFMETESWQAAKGKILALGTITTPDHDILVSGGNDSLVSFWSGRAGSDDPGAASARSNVASAPAYVRDCHEAVTFLRKKCNTFGANTHLFSPQQGVNPILLAKFPASNPSTSTRSILFYGHYDVVDADYDPSNPHPTWYGDPFALQPLSSFLYGRGVTDNKGPLLAAIYAVADLVQNGTLSCNVTFLIEGDEEAGSRGFRKTVESAHDAIGPVDFILLSNSYWLDDHIPCLTFGMRGVIHVSITVSSNKPDLHSGMDGKSVQHEPLKDLAVLLATLIGPSATQVTIPGFYDSVDELSEEEVKGYASITSSLLPGHPEIKNEKTFALSLMQRWRYPNLTVHRIEVPEAKTAVTISGSAKATLSIRIVPSQTAEQIAQSLTRYIKDEFAKLQSSNTLTVAITSKADPWLADVRSEIYEALKDAIVDIWNPDVAVSHQRAFKIADDIKSNPSTPSRPVPAPTFSSPKSPTSSKNPFYPNSSSSSTPTRPSHRRASSLAATGSFPPSALPREPLFIREGGSIPAISFLEHEFKAPAAMFPMGQASDNAHLDNERMRVENLYKGREVLKRVFARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7J3</accession>
    <name>A0A1C1C7J3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein AIM2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">AIM2</name>
        <name evidence="2" type="ORF">CLCR_06076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7J3"/>
    <dbReference type="STRING" id="86049.A0A1C1C7J3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06076"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07121"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="257" mass="29061" checksum="D37E52C45075347A" modified="2016-11-02" version="1">MADKEGYLAKPSADCCLKGSLHQGEPRGRIETVAGVETYMSTPQGKNNGNIILYFPDVWGFFNNGFLVMDAFADAGYTTIGLDYFRGDPVWKYRKDKNDPAPGFDYEAWKRKHTAVADEVTPKWVEAVKTQFGSPTTKYACVGYCFGAPYVCNELARDICAAGAFAHPAFLKEHHFRQLTKPLFLSCAETDHTFGTEARNEAIDILRNEKKTYNLQLFSGVEHGFALRCNVDSPYERYAKEESLRAIVQWFDLWLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7T8</accession>
    <name>A0A1C1C7T8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NMD3</name>
        <name evidence="12" type="ORF">CLCR_05798</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7T8"/>
    <dbReference type="STRING" id="86049.A0A1C1C7T8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05798"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07211"/>
    <dbReference type="eggNOG" id="KOG2613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="257"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="321"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT44529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="515" mass="58376" checksum="1A3ABCCFCB994294" modified="2016-11-02" version="1">MSMDLDASVALPSRHAPQAATILCCNCGVPIDGTASAGALCYDCIKLTHDVSEGIQREGVLHTCRDCERWLNPPSQWVSAAPESRELLSLCLKKLRGLNRVRIIDASFLWTEPHSRRIKVKITVQQEAYEGTILQQTFEVEYVVAFQQCPECAKSYTPNTWRASVQVRQKVPHKRTFLYLEQLVLKHQAHKDTINIKEVKDGLDFYFAQRNQAEKFVDFLTSVAPVRVKKSQELISMDVHTSTKSYKFTFSCELLPICKDDLVALPIKMAKSIGNIAPLTLCYRVGTSINLLDPTTLQTADLPTSTYWRAPFKNLADVGELVEFVVLDIEPTSQQNGRFFGAEATVARASDLGVNDKTYYVRTHLGGVLHAGDSVLGYHLTGTNFNNPQFEELEQSNNYSSAIPDVLLVKKFYARKKKPKSRSWRLKRMAKDEGELLPKKADQERMDADYEMFLRDVEEDAELRQTLALYKAKQQRKKDADEMSVTTAQTDEEVPKINMDELLDDFEDLDVNDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8B0</accession>
    <name>A0A1C1C8B0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_05648</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>riboflavin + ATP = FMN + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8B0"/>
    <dbReference type="STRING" id="86049.A0A1C1C8B0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05648"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07358"/>
    <dbReference type="eggNOG" id="KOG3110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="15">
        <location>
            <begin position="406"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="57"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT44688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="628" mass="68980" checksum="D31142651A94105B" modified="2016-11-02" version="1">MPLTKSRTSALEADGSDRPPPLRTAQTDDLNHFTHTQAGEDLSLEEQTAVLQAMTLESPPGVQSPPVVSQPSPSIVQSPASISTEFSYHSTAPTSTPATPMTPLSPTISNPSPSQSKFVSALQDVRHFAGGLISQPYESTKHFSILRHSFGIVYYTGPSTNLAITIFSDRELPPDRTLWLQRRGFSGKTGLKLGGLLGARSTWIDITPSVKAAAEQMNPNDERAWQRDIKKFLKKAPKELRSHRPRETDILRIPCDADDGYLRVVLCTEGGKRTLCGSPIFRLASSSTDSSVVRGSSLKTMPLEAGIKLAATVGRQFVTATAGPYVSTAREAVTNQITSVYQPSAVAQQAMTTAYDQSGVQDRLDNMNEEYDTARDGSYDRFEMEEYDALARPAVIGPASGPVTPFPVRFHGKVVAGTGRSRALLNMPTANLTGVPDEILMRYKGVYFGWAAVNLPKKLALEKSITDEWRQAIITIAPDPDRRRTVIHKNNARVYLIHEFGSVDFVDAKLSVMMMGYLRAIQEPQLDQEPDMEAELFDFYKDVCITNASLARAAWSVAETLERERSKASSRSVSERYVDFRQNTQKQIDRVPVHRLGVRTEGAALKDRLIGQGGVWIPRSAVAHAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8B5</accession>
    <name>A0A1C1C8B5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin MVP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mvp1</name>
        <name evidence="12" type="ORF">CLCR_05529</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8B5"/>
    <dbReference type="STRING" id="86049.A0A1C1C8B5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05529"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07450"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10064318at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07597">
        <property type="entry name" value="BAR_SNX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000072">
        <property type="entry name" value="Sorting nexin MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045734">
        <property type="entry name" value="Snx8_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554:SF1">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19566">
        <property type="entry name" value="Snx8_BAR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="323"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT44774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="652" mass="71517" checksum="34918052A3A6A6EC" modified="2016-11-02" version="1">MSLFGSSPTEAAPLNSKSLFGDEPARAPAVSSLFADDGGDSPWSMPTPKKNARQNLVKNLLPATDVPESYVDAYDAVLKANERTGVGIGLAGVKRLLQSSNLSEQEQSKILNFVIPGGQESANGVGRSEFNVLLALIGLGQEGEDITLDGVDERRRKLPEPRIDYLDQLRSNARPPAPSPPTAKSTPVRAPKSRQESFGADPTADPWGSPSTNRLPLPSRAAHTMSTNGVAEDGAMSTPNGIARTTSAFTTGESQGSGGSPVAERSSDSAGTGWNSYNGNSGGFAEQPTLGGGFGDSGNNSSRPGRDPQSAVSQSISLPPGTGESVTITMLPEKEGIFLFQHRNYEVKTLRRGSSVVRRYSDFVWLLDCLQKRYPFRRLPLLPPKRVQVWRKQATISVQEEFAGKALPPTLEDSLPSNLPDLFEQVRAGVRRSAEVYINLCIWMERLVKRNEGLASDSWKFSQAVSNLTEATGDSYAIDPNDVPLLNEGIKSTAKHLATTQTLLEDEAKAWDNGVLEDLKSIRDNFVSMRDMFDRRDRYAKDNIPQLERRIEASENKLQQLRQKPAGQVKPGEIEKVESSIMADKESIVQQHARGVFIQECIRDEIVTFQTTIYAISRMHQDWSQERVKYAELQASNWRSLVDQLESMPLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8D0</accession>
    <name>A0A1C1C8D0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N amino acid transport system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mtr</name>
        <name evidence="9" type="ORF">CLCR_05599</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8D0"/>
    <dbReference type="STRING" id="86049.A0A1C1C8D0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05599"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07445"/>
    <dbReference type="eggNOG" id="ENOG502QRQD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF20">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="79"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="521" mass="57205" checksum="15FB5BB98B710E49" modified="2016-11-02" version="1">MSDVREKSEPGFGEGGSFNPSGSVDLERRGSTTVHGRKMSRIGPPPKPGSLSLPDTSGSDDEYGKLVAMEADNAIKYRTCSWQKTAALLFSEYICLAIMSFPYSYSILGLVPGLILTVVQAAFVLYTSLVVWEFCLRHPEVLDVCDIGQMLFWNKKWAWYFTAVMFLLNNTFIQGLHVLTISRYLNTMSNHSVCTVGFAAIGAVISWVCSMPRTFNALSKLAAVSAFFTFVSVILAAAFAGAEGKHGTAGYNPDPNHVNANGVKLGGEPLVLAVPVAGTTFVAGMNAFLNISYTFIGQITLPSFIAEMKNPYDFRKALWLVTICEIILFSLVGGIVYGYTGTQYNTAPAFGSLGNDIYKKVSFSFMIPTLIFLGVLYASVSARFIFFRVFEGTKHKTQNTVLGWAAWAGILAVTWIFAFIIAEVIPFFADLLSLMSSLFDSFFGWIFWGVAYLRMRRADLGPGFYKKRGLRGWIGFLMNIFIIIVGIYFLGVGTYASVDSIILDYRAGNVKGVFTCADNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8P7</accession>
    <name>A0A1C1C8P7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arrestin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8P7"/>
    <dbReference type="STRING" id="86049.A0A1C1C8P7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05544"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07582"/>
    <dbReference type="eggNOG" id="KOG3780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF174">
        <property type="entry name" value="ARRESTIN-RELATED TRAFFICKING ADAPTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="314"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="713" mass="77956" checksum="C7885EF16ED9FE8C" modified="2016-11-02" version="1">MVFADVGRRSPERRGRSSSVVSGVSNRSRHNSNARTATAQPPSPETQPVAPSVTLLADEKPVASGNGVSVSIALAEPVLFLQGYDANDPSTHSTTMLRGSLLLRVQKQAKLKSISLNFRGKSETEWPEGIPPKRVEFRDTTTIMNHTWSFFNAQFPQAEYSYGADLVQLSKGPSVEAKELGVTASSFDLFQRSASPAKGHTSTRELKRLSLQANHSRSFGKGDTINGGPTVAQRGFKVFHPGDYVYNFELPLDSRLPESISVDLGHVKYELEALVERSGAFRANLVGTKELTLIRAPAEGSLEQVEPIAISRNWEDQLHYDIVISGKSFPLGSTVPIAFKLTPLAKVQCHRIKVFVTENIQYFTNNKKVHRLEPTRKVQLFEKRADGHSVTSYPGSSMRILAGGGVPYDYRQQAAAGDEDIPRDQTNLLGNLDNDAGSIGPTEMEFNVQLPSCHQMKDKLRSERLHFDTTYSNIQVNHWIKIVMRLSRPDENDSGKRRHFEISIDSPFNILSCRATQANISLPAYSAGDGVPSSTDEFECGCPGAALRRRNTPPVSQNRIQTVGASADGPTPGVSRSWTNDTGGLAMPTQAHVHNDPNSGQSRPMHLLRAPSFNPPAFDDDEAPPPLVTPPPLYDNIVSGDSTSALADYFARLADETSDEDDRLDRSRVDHPLTPGGRVNRSMDIPRNWLPLDGTSHSTPAPSGLATSASVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8R1</accession>
    <name>A0A1C1C8R1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosducin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8R1"/>
    <dbReference type="STRING" id="86049.A0A1C1C8R1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06094"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07584"/>
    <dbReference type="eggNOG" id="KOG3171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70588at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="75"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="298" mass="33018" checksum="89E43D4CDA60400C" modified="2016-11-02" version="1">MADLAREEAERYFSHREHPTSHPEDRDQDSIHLSDDQAEPEHGDDFSDPGTDDDTIANMATMTTTRTTYHLPTQTHFANTGPKGVIADAQSYNRAKQSTFRQRLASFANNLASNGKSTAATAVTEKKDKRRSIFGTSPKSTTSSDSENIALSDDDADSEFMQTWRANRLQELSTQSQSAYQRKPSQRSWGTFQEVDANGYLDAIEKVSDDTYVVVMIHDPASSQSAEVEDELGMLAYKHNTTRFVRLDYRLAEMETVEIPAVLAYRAGEVVATISGAKAEGLEGVLLHNVDVDVDVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8Z9</accession>
    <name>A0A1C1C8Z9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8Z9"/>
    <dbReference type="STRING" id="86049.A0A1C1C8Z9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06197"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07677"/>
    <dbReference type="eggNOG" id="ENOG502S45T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="242" mass="26990" checksum="5DD61BCE57D5387A" modified="2016-11-02" version="1">MASLAAKLVARKLFQENSSNNQGREDPYFETVPATRLGGLYKTSKKRKRALPPGLTPEEERILTKAKRRAYRIDLCLGSFLGTRFGWGAVIGLVPAIGDFADLLLALMVYRTCCSIEPGLPSSVKMRMQMNVMIDFLVGLIPFVGDLADAAYKCNTKNVVLLESELRARGQKRIKGTPQANVADPSLPDEWDYQNDEAVLNAQNGPPPRYTSQRESRRSNRERQRDLEARGGVQPPLPARTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9A1</accession>
    <name>A0A1C1C9A1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Capsule polysaccharide synthase Cps1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_05649</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9A1"/>
    <dbReference type="STRING" id="86049.A0A1C1C9A1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05649"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07723"/>
    <dbReference type="eggNOG" id="ENOG502SICP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2849215at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="551"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT45051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="628" mass="71799" checksum="6F3656701FABE6D3" modified="2016-11-02" version="1">METQLAIFQPFRSTLSLIVRHPNLLFISLFVFRYLRFVVHVFSYFRYRPSTLSKHPRLKRKDCTVVIPTCCPEAPAFSHCIASIVQNSPKVIHIVAVGKEQEKQAWSTIAPFISGYPYIHFKVSHSDEANKRRQVALAIASITTHITILCDDHVVWASPRFLRAALAPFEEDRRVGGVGTRKHVIRHSGIGLFRGFWNVMGALYLERHNFEHRASNAIDGGVAVISGRTCLYRTTILQDPALLAGYLNETFFFGLLGPLNADDDNYLTRALVKRNWKIKFQDTSDALILCDVGVYPKFLKQCLRWARTTFRSNLCSLITDRSVYQAQPWSVYALMISQMVNFALFYDGAMVWTLTRTGFYSGSVLKALCVWVLASKLPKLLPYFWRHPRDLIYLPTYYLFAYFHSLIKLWALLTFWDVQWSGRDLASINQAAMGEKAAQGPRVIPEAEYVNFSDDPTKHNTTTMPPRTPTRPITQPTNRQQRSTPQPIGTPWAFVQPVNLHRTPANVLQNQLAGRSWPALWSVRERHAYQDQGYHGDHSPVALQFEENLATRSLTPKSSSNKRKRTETTSFTNQTPHPLPLTPPDSPPPFRSLSTPSRMPETPTRSFVRADQCGRLHEGYYPRRICKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9X2</accession>
    <name>A0A1C1C9X2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9X2"/>
    <dbReference type="STRING" id="86049.A0A1C1C9X2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06296"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07920"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="218" mass="24160" checksum="421B79E29371BD55" modified="2016-11-02" version="1">MATSGSKVAPGGQGSAFLVLSQKGDLGRLRECLLCTAAITVEFGALGEAGVRTSAFRQLVRIARANHHQLLSLPAEASDQDTHDRLIFLITRLAALLYHDMVIFPQVDTSGIKPRLAEQLRHHLTERSPTLVPGAGQHEYRGLVVWALLVGSIGSTWTRNRTWFVEQLHRRSQLLGLETFAEFKTSMSKYLWSENMDEPALRAWTEGEAAMLSSYEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9X6</accession>
    <name>A0A1C1C9X6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9X6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06058"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07895"/>
    <dbReference type="OrthoDB" id="5089849at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650659" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="30251" checksum="B173C510B36BD8CC" modified="2016-11-02" version="1">MFPPSPLLDRLIISILSSLIFTSCAQACSTLSFASIYQSYPDCAASCLACPDTDYVNNFAHNCNYTNGDCCRSKFHTVIAESWACVQQSCDGMALAQEAFDIFAKHCEHVDVPLASVDIPQGYASRTDDGSPGSPDANPDGDTDGTAVSSPSPSSSSSAPLSTGTIVGIATGSVVAAAGIVGAIFKCLSYRHKKKQNTSSNGGGVGGGGQTPATTNNQLVQWQPAWQGMPPGALTGDADARATYKRKEFAFAGVRRVKETFEVTRQPTPPAGAVLGGAGGEGRGRGRILGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9Y2</accession>
    <name>A0A1C1C9Y2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TPI1</name>
        <name evidence="12" type="ORF">CLCR_06040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9Y2"/>
    <dbReference type="STRING" id="86049.A0A1C1C9Y2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06040"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07927"/>
    <dbReference type="eggNOG" id="KOG1643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT45278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="269" mass="29080" checksum="05547450D9D135B5" modified="2016-11-02" version="1">MGRKFFVGGNFKMNGTIQSIKEIVHNLSTSKLDPNTEVVIAPPSLYLLLAREHLSPNIEVAAQNVFDRPNGAFTGEISVAQLKDSNITWTLLGHSERRTILREEDEFVACKTKAALDGGIGVILCCGESLEEREQGITTDVVTRQLQAVNKTIGKDGWKNIVIAYEPIWAIGTGKVATTEQAQEVHAAIRKWLSEAVSPEVAENTRIIYGGSVSEKNCRDLAKQPDVDGFLVGGASLKPACALTFPHNGAAPDGTLTFLLVVEIINANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB26</accession>
    <name>A0A1C1CB26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB26"/>
    <dbReference type="STRING" id="86049.A0A1C1CB26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01490"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03621"/>
    <dbReference type="eggNOG" id="ENOG502SWPC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="581" mass="66566" checksum="B32705729C5C30B2" modified="2016-11-02" version="1">MASADGSPVDRKKQLSKRSSNSYTSEEWRRHRPLITQLYFEEGRTLKDVAEYLKREYDFGPTERMYKSRLHTWGLDKKKKEHEMLDLVRQGLQQKGDDKDKVFLVRGRQVTLADALHYFNRKGIKDPSSLLEPQRALSGELSSPDDADVRTPLSSNDDMLHAAHDAEDFEMTRSPMEMDEPDKPAISLRLRASEFAAERLAILQQALNIPDLPPMPPFRTLSVESTVVQAQVSAEDQRYLDGIFQNMQNHFMNLFTARNLSIRNTTGTWTATSDDALADRFYYSMYHGFSFLWNGQRDRAFDNFYKAFALIEGLLKDDHVGFMIYVFDLIIRHDGTGYEEPLLMLLQHLADMAKAVFESEEHPIYVVATTMHNATASRAWLAESTLRRLLDFFQDSIGYFHPETIALLQTFASSLLNRERFAEAAVRFQQLVDAFETTVNKQCYDVCYALRSTSEAYFHMGQYTQSLQAIKASLERSQTLPRPEEREIYVRCLRGMAEISHKLGRKDEAVETMQHVVDVCRDAFGPEHAFTNRAKMHLKSILKGDAATASAIPPMVYRLGRGGNAAKYIWISRSSPTRLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB49</accession>
    <name>A0A1C1CB49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_01710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB49"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01710"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03666"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="219" mass="25078" checksum="137D0A3E556E8EC6" modified="2016-11-02" version="1">MKKHNIRVGELSNCGLHMTFQQIRAAPISLRLKTRMNLLRATDKLTHTAGENVLCCRAFFVTSSFESRQHSIRLTPFYTRPDTFPVPEAEPCSQASKPVRFSMETILHAYQPKRTLLLLEYVNRSGKEDASRKLSSPPNVLLFVGGLYDNFRWPRYLDDLAALFPRDVPDQQWRVMQVQLSSNGRSWGISDLDRDVSRIELLLRRKVSITSHQTTGDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBJ7</accession>
    <name>A0A1C1CBJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkaline phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBJ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CBJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01456"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03741"/>
    <dbReference type="eggNOG" id="ENOG502QPM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2100241at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF2">
        <property type="entry name" value="ALKALINE PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G03860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="272"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="697" mass="77128" checksum="B0A0031F1889E49B" modified="2016-11-02" version="1">MPSTPEIVAATSSSILRLAAFVFLRWIPGWPWPPTVLTALAIYLTTVFGWSDAFGSSRPTLHEAFPRLFPHPDEDENKERDEKDAPTILDHDEPVLYEDEKALFKTLLFGIPNWRHPAKSYLTIAANVLLALCTLDLVFRGPLLHAEQHLSFVRVGYVDTTSAKVLIREPDPAQFPIYVYLSPADQTQWKTTDTLYWMGADTDYTHALTFDGLQPARKYIYSLSNDKSGTFTTAPAPYSDAANSLTFLTSSCIKANFPYRANAHSLAIHGFGYLSRVVRSLPSPASFMLFLGDFIYVDVPIRLSYSLAHYRAEYRRVYASPSWSLPGLDALPWIHTLDDHEIANDWSAGNETDPFPAASDPFIHYHVSVNPPVPPGAPIGPESNTTYFQFTHGPASFFMLDTRRYRTDPEPESTSFSPSASPKTAIPGSSAESSNSNPHSMLGAQQLSSLLSYLSTAEPPHIHWKIIASSVPFTKNWRFGTSDTWGGFLSERARILQTMHDAERVLGIRVIILSGDRHEFAAIRYPPPVISLAPVATGPVSASLSSSLTSGTEGTDTDTPIQRDQTPAAGPHEFSCGPLSMFYLPFRTFRQIDDEDVPITYIPDGNSKVGVVEIRNLRRDAGPRQSLLKYSLYVDGRLTWEYALSSPGASASASSRAALGGDDNRRAQGWRGWIQGIGLPRGSGSSWSRSRSRSLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBS8</accession>
    <name>A0A1C1CBS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-dependent phosphohydrolase HD sub domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBS8"/>
    <dbReference type="STRING" id="86049.A0A1C1CBS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00513"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10075"/>
    <dbReference type="eggNOG" id="ENOG502SRKJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2378324at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="64"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="239" mass="25693" checksum="BD6A4936DDD4816E" modified="2016-11-02" version="1">MCGLSGAAGPGAVAPETTLSHSHSSDTDAPDDAAASLRVFVPHSTLCAAAFDLVISAALPLSILHHSIRVYLFANWLADKEKSEWADSDLLFVACMTHDIGASHKHDGPQRFEVEGADAGADLVRSHSKSEADAHEVWTAIALHTSPGIAERITPLARLVRLGVLIDFRLATRSSLGAVDYARDIEARLPRLDIEKVLGDAVVEQAIRNPAKAPAASWPNNLYKSHLENPQWDGINRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBU9</accession>
    <name>A0A1C1CBU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBU9"/>
    <dbReference type="STRING" id="86049.A0A1C1CBU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00369"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10058"/>
    <dbReference type="eggNOG" id="ENOG502S93S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5396252at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42068">
        <property type="entry name" value="YALI0B18964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42068:SF1">
        <property type="entry name" value="YALI0B18964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="849"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="935" mass="99862" checksum="11B9BD218CEDACD8" modified="2016-11-02" version="1">MPIKLPRGFQRRKSSGHALDEVRSPPGESTFRVLERPASKGKSFDGGVHLRMTSTGGPMPPPKDHDGNGEVDIFAVGRPDASNRYAKETSLQTNEARLTLVSRGSGGTERSHSTAPYDSAASSARLSTSSTNPSSIDTKSDKNVQAPGTRPYNDIPVPPPASARPGFLRSPARTFSFGVVKGSRGSPTSPDAALPPLVNNRRNRTVTESTASTATPPKLFDSDLALENSELDAFGNMFDHIGSSPDPGPTRLIHQEVTDSSPVTSYPPTAYPGGSALRTSRAPPPHPIATDRSQAVESSPYSWNSQTSRDGLMRSPSPSTTITQGSPVKSREPATQTGRFGSMSELSTSMASRRPVGPKGTTQEGDLHPAPLSPTKSRESAPPSASSARDAMGLSPASESSATFDPVIAENAQLAHMYQETKDPPPKPTRGNKVMTPAQWERYKEQKEMDRRLGALSDDSASEAGENSDDDDDELERSKQAAKQRRKQEAHLAVYRQTMMKVTGEAPPNRPGSSLSALRPGNGSSTDLNNRMSHITLDSKTSGKSSGEDEDEDEDVPLGILAAHGFPNRNRPPTRLATSPSNSNLRAVSQNQGAPSVKGGNLPVFARQLPPDPYYGAGLVQPSNREALALHPTAVPQGAGPSTAHPIHPSGLVGVIAGEERARAARRGSPNPVGGFDMPPHPGMARSQTTGTLPAMGYQGMPPMPGMPPMMPGMPPVLTAGDQAQIQMAQQMTQMMQMQMQWMQQISQTMGVPGNPGPMNMAPYPGMPNPALSRPQSVHMQHPSAPQASQRTMSTLNPSMAPWNSGQQLLPSINVNGSYAPSIAPSERSNIGLASRYRPVSIAPEPEVGAHRRASTFTSTSMRPWSSVDNAARPGQHGTRPSINTLGRRSPLAVQDEDDDEQGWAEMKMKKDKKQKSWALRKGQNALQELYNPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCC5</accession>
    <name>A0A1C1CCC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trans-aconitate 2-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tam</name>
        <name evidence="2" type="ORF">CLCR_01292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCC5"/>
    <dbReference type="STRING" id="86049.A0A1C1CCC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01292"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09397"/>
    <dbReference type="eggNOG" id="ENOG502S1YX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.290">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023149">
        <property type="entry name" value="Trans_acon_MeTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002463">
        <property type="entry name" value="PRK01683.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="281" mass="32061" checksum="1C080FC32AF222CA" modified="2016-11-02" version="1">MDSQAQDWNATQYLKFEAERTRPARDLLAHIPLTSPARVIDLGCGPGNSTAVLATHFPDAHITGVDSSPDMIAKARARLPGVDFKLGDLRDFTQSESQSQTDSQQQQQQQQHPQLIFSNAVFQWLPHESRMQILEDLLAALRPGDVFAFQVPDNFDEPSHRAMRETADQGPWAETLRPVTTFRRSFQSPRELYDRLSPLCRDGRDLDLWHTHYYHVLDDAPAIVEWVKGTGLRPYLDRLSPLERTAFLQEYLARVQRAYPPLADGKVCLRYPRLFVVAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCE9</accession>
    <name>A0A1C1CCE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative calmodulin-binding protein Sha1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_01050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCE9"/>
    <dbReference type="STRING" id="86049.A0A1C1CCE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01050"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09311"/>
    <dbReference type="eggNOG" id="KOG0165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21223">
        <property type="entry name" value="CH_ASPM_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="411"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1094"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1107"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1145" mass="123460" checksum="B061B032F6877ADF" modified="2016-11-02" version="1">MSRHGITVATPCPAPALSHHGKHDDSIARRTSTGTSVFREDDDDDNDDNDNGGDTANIEFTAAFPRHNLGLGLGLGLGNGPGLGNGPGLGPTAGLRNARPRRRRAADVLGFAIHEDGAGAGAGAGAGAGAGAGAGALMKAVRRNAGAGVRAGAGPGPRTATGATASAIAQPPQRPKRSVNLVGPVASTSASTSTSMGATSSVHDAHDAHSIHDAVYQHNFSELANTRTDATSRRLSQAPRRPVVNKVDSATAVAPPPSPPLVPEQTISMPTLTATTVVLKPAAARRGTIYIPSEDTTMPSMYMGMFSPIKDLDAAKAGSMSAIAEDVEITGIAAQMLAKKQRGAGRKSMIAMSPKRGALQVSSGNLQDSAVVEDRWGQGGGKENVPPGRAEAGDKKTKLIKRTSVVDANGTSVETASRRPQLQATRVSRVYESTASARTKANDKKMSQRPTTKPGWNAGPRLKTSQPVPVRSQSPEPRSDSMIPHEDVAQNRKPSIPSRFVMPRLGLQQRIREIYPVLGDDLADLSMYEDNWLNHQEIAITQLLNNLFGASTTVHSPVDSEMVRIRLQERYGGGENALLYKRLQGALLYGSLCVPSEILKGAGRLSSDLGRRKAYTDLWLETYDLSCLQSAVEVVVGRQCTKTRTSSSSRRSSDGQSVSRRALQAFIETFMIRNEDGTPDDLGADRAAWSYQRTLLRSLMLIKLLDSTKPLQQRLFHGCLFQPSSPYKSSASVVRALFQLLNPSAGDPIRALSHVAYTVSHSQYPLEEYSYRIENIAVDLRDGVRLTRLVELLLYPSASNSLEHVHDAESSTTVVLPDGELLLLTDGERDWPLSQHLKFPCHGRATKLYNAQIALSALHGVKGMAALVQDVRAEDIVDGYREKTVKLLWGLTSKWGLSGLIDWDDVELEIKRLCRIGNSSQDNDFYDMVEEEEGYARHKVLLKSWAQAIASKKGIVVKNLTTSFADGRIFEAIVDEYEGYVAGNDKDKDSSSQSRPLSARLRGLGCSEQFSMLFSPTSPGSPNRTHLFDRDFVLAALAFLCSRLLGPTKAVRSAVTIQKAWRSYWARVLDGRKVMAKALAEGCARSVRDRGCRRTAEANNGGPNMDLGKDRGVAEGRDQAESGSNIDAGIAFPAETEEEDIWLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCJ4</accession>
    <name>A0A1C1CCJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_01318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCJ4"/>
    <dbReference type="STRING" id="86049.A0A1C1CCJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01318"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09277"/>
    <dbReference type="eggNOG" id="KOG3259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000066">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000026">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="67"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT46243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="178" mass="19837" checksum="D410DE6908432DEA" modified="2016-11-02" version="1">MSDDTGLPPDWEVRHSNSKNLPYYFNQKTHESRWEPPADADTDKLKVYMANHHSSSANGRVDGAAGEGKIRAAHLLIKHRDSRRPSSWKEQTITRSKEEAIEILKRHEEQIRSGQTTLGDLAPTESDCSSARKRGDLGLFGKGQMQKEFEDAAFALQPGEMSGIVETASGVHLIQRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCR2</accession>
    <name>A0A1C1CCR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dimethylaniline monooxygenase (N-oxide forming)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_01161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCR2"/>
    <dbReference type="STRING" id="86049.A0A1C1CCR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01161"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09243"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="541" mass="60474" checksum="EF313A66BFD4BBF2" modified="2016-11-02" version="1">MADTQQPSVAVIGLGAQGVNAVKNLLEQGFTVTGFDRNSYIGGIWHYSAEHNVTALPSTIVNISRERACFTDFAFPPGTDSYPSSAQVDKYLNEYVDAFGLRPHLRLSTGVESIERDDTQNCWHVTVSGPNPAEPERLRFDKVVMATGPHNQAIMPDLPGQELFKGEILHSIAFKDPKLFRGKRVMVVGASNSAADTATSLIGIAQEIFLSHRHGTVVMPRHLKNGKSLDHGLSYRQFQVKDAMDSVAPWLSILFLNGFVNKTQRDEFGTFDPQWRLQPSPSLLHQNPTISDTLIPALRDGAIASTHGPRCVTGDWTVELQDGSTLTVDSIIFCTGYSLDYSILGEYDPTLNPSVPGGHVNDTPQLYQNIFSLHYPDSLAFVGLAIIIFPAFLLSDLASMAIAALWSNRPETPSLPSQQEMEQWYAEHLTWVSSIRALSPLGKFVRLSVRSGQWLPWVTDKGGCNIDHHLGYFTADSWRLWWHDRQFYNLLVHGIYSPHFYRLFESSRPGGRKKWDGAREAIVRVNEEVRARLEKRREQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCS1</accession>
    <name>A0A1C1CCS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCS1"/>
    <dbReference type="STRING" id="86049.A0A1C1CCS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01234"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09197"/>
    <dbReference type="eggNOG" id="ENOG502S1HE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="390" mass="42349" checksum="362108E4A5B44759" modified="2016-11-02" version="1">MHPPGLPPSPAAQLDHDIVSALQTSSPPSLAVTGTSLIFSIATAAASQTLASIPNPAKSPAAPMSDDDESSGECKLLGPFAILVQAALGALALLSLVFKRWRERPQRPLKVWSFDVSKQVVGSVLLHLLNLLMSMFSSGQIGESVVNAAATTLGAETTEAYQPNPCSFYLLNLAIDTTLGIPILIGILKILTIGARYTPLARPPESIESGHYGTPPKAGWWAKQCLLYFLGLIGMKICVFIIFQLCPWLGRVGDWALRWTEGNEAVQIAFVMFIFPLIMNALQYYIIDTFIKQKNRPQLDGGEHNERERDGEHGALLAEDGPGDGRSVDEDEAHKARNVSPSPKRSDQLERIISYDPDKDGELDSTRQDGASSSLTAEAEDEAIEHRPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD02</accession>
    <name>A0A1C1CD02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD02"/>
    <dbReference type="STRING" id="86049.A0A1C1CD02"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01197"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09137"/>
    <dbReference type="eggNOG" id="ENOG502QU1R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3944408at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="471" mass="50889" checksum="1EEA0DFD25FAE35D" modified="2016-11-02" version="1">MASQRRTKNFANDPQTPMFLYNILKQLDLRSINWSEVADGLGISNGHAARMRYSRMKSQFEGLSSQPKPAKPKNENTSASKSAKSKAKDNKRRLIEEETERLGSGQPTIQSAMHQDHGHKRIKAEPQSYTNAWHNTGSIYTGYTSQPGANTYWCQQNTRAEPLPPAIPTGPPQSISSTPAIKQESEATKPCPTDAPSSAPAIKQEPSLPGEDFNMADSDIVEVECGAGKSWTQRSPTTAYNVPIAPSYPLTRTINAYFDRSHSPFLSTQPRPSMDSMAGYVTSQTFSHGAYPYVTHGNTTPNALSWIARPLGHKATAMSLEDDSRNMMLNPYATTYQEMLNMPLYRRSPSILPIPNPSTQQTVSPPTADHAQRQGREQDVRIAPSATVTPAPEEQGPLNTTASLSTGTSPASPEPAAGAPEPPQDKTVGEQSTVANASLGKTGAEGVGNAASTTLVIDNTVVNIKTEVVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDF2</accession>
    <name>A0A1C1CDF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CYP-1</name>
        <name evidence="8" type="ORF">CLCR_01938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDF2"/>
    <dbReference type="STRING" id="86049.A0A1C1CDF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01938"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01289"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF164">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650740" evidence="7">
        <location>
            <begin position="24"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT46560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="516" mass="58244" checksum="361F981F8F5780F4" modified="2016-11-02" version="1">MPISLWIVLALIIYAATRPSSRAAKLRKIPGSWLYATTRYRLAWDAWHARSIHAVHGLHRKYGPVVRIGPNEISFNSLPALRTIYGAGSGFERTDFYRMFDVYGRPNLFTFASGQLHRERKKLISHIYANQTVLSPHFAGLVKSKVAAYLNLLEREPDLGSEIFASLHYFSLDAKSEFVYGSKYGGTTALAGSKQSRDLIQDILNPARRRLAWFAVHFPAYTKWITTRTGISERLLTSMGMMPMRKPFTYSGIRQHALEAFRGFKGAPHKDKANSADSTVIGRLFKVQEAANLSDMDIASECADHLLAGIDTTSDSLMFMIWALSLPRHKHCQERLREELSQISVDSQGLPEPKDLTQLPYLNAVVRECLRLYSPLPAFEPRSSPVDTVVDGYEVPAGTVVGMSPFCLHREETVYPSALTFRPERWLTDRGTLIPESDPRNRTFWAFSSGARMCIGMHLANAEMLTLLAAVYRKYKTSAKHPDTSPGITSRFEIFFDETMPKMVEHECHISFIKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDI5</accession>
    <name>A0A1C1CDI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02157"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650787" evidence="1">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="137" mass="14604" checksum="2DB54BB57F292D21" modified="2016-11-02" version="1">MKFILPVLATLASASLTQALTFGYTQQVTNTEPIPPPPMRFARRQTSTADASGTVFCEDVSEGIGGDDGEFPADGEYHTLTCTDGTLMAFKISDCDEDGNACGQAIANWAGADVDMNACTHTSDNSISVFNMWTCNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDJ4</accession>
    <name>A0A1C1CDJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02112"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01269"/>
    <dbReference type="OrthoDB" id="10304236at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="200" mass="22024" checksum="FACB69BEE87D28EE" modified="2016-11-02" version="1">MKCATATDLQSTSALPTPWSLLNEHFQPFRDVDEPINSFCNNLAGRNATLWAGTLDKPGTTLGECNQFSSENNSMVPITQTGHRLSIGLTYVNACGSITEYDLGVPMGDYTADQCARNFKYIVSTCTLPGDHLKKAGLGDYKHIGGRLWHDCMQYTILATDPAHSAPETYDINNEARRALGDMNARDALRRLASTLLAWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDR6</accession>
    <name>A0A1C1CDR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02197"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="73" mass="8249" checksum="AF44A328EBA327BE" modified="2016-11-02" version="1">MEAKLPEIRPLKLSPPVDWRLLEASIRDAGPRKRGDDKVKPGLAWAGRLSNLCGLYWVWSPSSAQPWALPWNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE02</accession>
    <name>A0A1C1CE02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE02"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02027"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01468"/>
    <dbReference type="OrthoDB" id="4136797at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="289" mass="31584" checksum="1DC59938450B568C" modified="2016-11-02" version="1">MTKAADPYYNRKPVPDELIKDVGLTGLTPDEEFWNREKKFTAQGADVRRFSNSLHGGLEPLADPYYGRRRVSQAEIANVGATGLTPEEEYWNRERKYSVGGHDVRKFSKGTKSSLEPSTDPYYSRRRVSAAEIKNVGPLDDHMTPAEQYEVRERKQSLFQLSSDPFDNLANRHRQSVSGAVTGASAAATRRRSSAVAPDATVATAAAGHSHSGYDSGHKLEPIVSKADGPTASSHNGESSLSGHISDDTLNRDSIDPVGGRSGEHTRHYDAVTTGHHHDPDSVAPHEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE24</accession>
    <name>A0A1C1CE24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE24"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02088"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="126" mass="14048" checksum="3630E6D4517729C1" modified="2016-11-02" version="1">MQGESQCEAVTLQRKASESRLETGESRVKALEFRVWSSGRWSKAETGGRAGAEQDRIRGTEDEARSGMSGGEVKWLLKRNGRWGEVVAEDEWLGILYGVLRDSHAPQGTEYGVPRTELLLVLVLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE28</accession>
    <name>A0A1C1CE28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_01903</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE28"/>
    <dbReference type="STRING" id="86049.A0A1C1CE28"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01903"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01437"/>
    <dbReference type="eggNOG" id="KOG0169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF169">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="313"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="272"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT46718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="589" mass="65689" checksum="0585F7DF9177FA00" modified="2016-11-02" version="1">MTSRLTSRMAKLNPFASKPSRKIDDEDAGDVIDASTVAGGGHAALETEVTKHQLRVSPALREFLVSKDVLSKKDAGLENPSELTRPLHDLVNRDHINVPAYVTDRSHPLPEYFISSSHNTYLLAHQLYGTSSADAYKTALRTGSRCVEIDAWDDEDNKDEPKVTHGYTLVSNIPFRAVCETIRDVVDEEAAQSLSHPGHRAAPVLLSLENHCDAHGQQRLVEIMKEVWGDRLLSKAVRQKGHDEQRGTGEQVTLEELGSKIVVIVEYHFPSEAKAEDEDDSDSSSDEDEETAQARKAYNEKKKAAPTVIVPELAELGVYAQSVKPRDNSWFDDDGLKDAPHHHLINMSETGLLTHLPAESHKIARHNAVHLMRVYPKGTRISSRNLKPVAFWGIGAQICALNWQTFGASIQLNEALFSGSDGYVLKPAALRAGGNGVLNTGRRKRLRLHVGGACDIPVPEGREADDIKPYLTCTLYHPDFLTDDDIPKRKTGHYKQHKLGLVHKWANSPATDPIWDEVLEWEYDDNEMVFLRLLIKSDDAFARNPILVVSAVRLSYAVEGWSFIRMLDLKGRETRCSLCVRFEVLDAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE39</accession>
    <name>A0A1C1CE39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_01834</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE39"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01834"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01512"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="583"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="723"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="61"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="227"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="436"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="772"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT46794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="820" mass="93226" checksum="109E40E2F7E66D53" modified="2016-11-02" version="1">MSVRDSKNPSWNDQFKSTNQRDFNLQVIISVVFGLSAFLSFCVCTHPTQRNPQWMLTSAQVLRPKWTSLYHARKKQSGAASRLPELPKSLFGWIPVLLRINEAEVLASAGLDAYAFLSFFRYAVKFLSVTLFFSLTIILPVNYKFTGELPYPPINGTAPFVVPTFLSEDDTKRPKKPKIEKDDSYLWMYVAFAYFFTGVAIFLLIRETTNIIRIRQAYLGSQATITDRTLRLSGIPSEMRSEEAIKHFIEDLQIGKVDSVMLCKNWKALDELMAERMTCLRKLEGSWASYLGHHHSMRHSRRTHRQRNGIDGDEESGALLSRSEMEQAHATPADRPRPTHTIRYGPLKLYGRKVDAIDYYEEKLRVMDEKIHALRSTEFKPTPLAFVTMESTAACQMAVQAILSPKPGELLASLAPPPADVVWKNTYLSRNVRMARSWSIMIFIGFLTILWAAIVAPLAGLLSIEVIDKVLPGLAQALEDHEIIRSLVQTGLPTLLFSLLALAVPYLYDWLANQQGMTSQGDVEMSVISKNFFFIFFNLFIVFTIWGSATTFYDFWQDLRDIFRDTAGIAYAVAKALEQLSPFYVNLIVLQGLGLLPFRLLEFGSVALYPFYLIAAKTPRDYAELSQPPIFSYGFYLPQTMLIFIICIVYSVLPASWMITLFGLVYFLIGGFIYKYQLLYAMEHRQHSTGRAWPMICNRIITGLVLFQVAMTGILALRGALTASVFLAPLLAGTIWFTVYFQRTYVPLMRFIALKSIDRASSPQLPTPPESAWDRDTDYGRDVDTSQDTGLRYINPNLVRPLETLWIRKPGHGRPEHSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEA5</accession>
    <name>A0A1C1CEA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_01932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEA5"/>
    <dbReference type="STRING" id="86049.A0A1C1CEA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01932"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01575"/>
    <dbReference type="eggNOG" id="ENOG502SSVT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5426678at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650817" evidence="3">
        <location>
            <begin position="40"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="451" mass="48628" checksum="5C9684EA885DC805" modified="2016-11-02" version="1">MAYWHDRSATGARSPHPPRFRQIALLYLVLTAFASVTSALQSVPGSPCESVCSDAGTLENDVVCLDANYQSLSSGRGFQKCVACQLNSTAVDTVNNNTDVEYGLLALRYTLAGCMFAIPEDHISISSPCQVSCAPLNDSVGYQVTNDSSRTEPGGEFCTAAQFDDTTINNRLLLTHLRMTVLQALHIACREPPAPGRPFFPDAQAIFNETLIAGPAPPSRGTNDNGGLRGYKLALAIALPIVGGILLIGGLCWGCFAFTRKRRYKMAQSGRMSRVHDAHADGNSLYQSPMSAKAEAWKKESIPWGVVEPAREMHAISPTLLHAGKHSPGAAQGRWSHQTGGTGANSEQNTPLRSSFQRDDVGPGPAQVKDPNLHEQYFGVSGDSEDERAEHGHGVPFPGTSGVGVAIGGEEGYYPHTEGQYAYAQEYRPEHGQEHGHGQQRLHDDERGQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEA7</accession>
    <name>A0A1C1CEA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02110"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01579"/>
    <dbReference type="OrthoDB" id="10389648at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="181" mass="21252" checksum="C89BFDA1DFCCC4D2" modified="2016-11-02" version="1">MSSEAVDDQLIKEIKDEIEAITGDELPKDFIRYGPSFTRQSLKRLVHGTMLAEFGRDYLIQNDALEVLLLFAQFHVACIMRGTYLWRAQTLKSELFYSVCSDDTWRMGQLLIATFPQIAANLAARMDRRRTIEGEDFALATKLLEEKEHQMMLKRAYERWVRKDRMGGLRYSLRTRGWYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF02</accession>
    <name>A0A1C1CF02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_02240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF02"/>
    <dbReference type="STRING" id="86049.A0A1C1CF02"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02240"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02341"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03476"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="722"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT47079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="995" mass="108948" checksum="5CEA14390C50C07F" modified="2016-11-02" version="1">MTDSLPTTWKRCAYCERTFSKLEHLRRHQRWHTGEKPFKCAFCGRRYARSDVLARHIRNHHPTADDGPEDILIEPAVPPANPQEHGRTSESPDPAHSPGQTQRRCSEASDMSAMLGRPSEQSTTTTECVRFVPSTGGNSPSTIAPQIPARRPNTRRVNNPGDISLTWKSPILGPAPRTDNRERPESIIAAGGDMSDVHSKENARCARTVGDLAPDGDTIEVSRLSENHHARMMQDNETSQPAHLPQEHNLIHPQADIVTPTIGQQYFTIPISPYPEDMDISGEMSAELGGFDTGDIDFTQTYNAPDLLWLESAIINLPKLDSVVPSLPTPGEDNELCQDQLSNHGLSADRLSRVQKAWPTKLVRPIRLIRRLWQTALQHPADNILCHDSTASPSQSPQRSNLTGSRWNMDASCRDRLLQDSHKIFGKEESPYAIPVDQTSNTPQSSMSTTYEAQFPSVEVLDMSLDLYFQRFHPSMPFIHQATFDARSAPSAVLFPMCLIGLSSLDPRGSRDFLRTEWTKLVHACRLELTSQALGKRPPLELITAVAASLLVLNLALCISRRLDENEAHMLCIETLHVSEKHGLFAACDGQELDLDLMGPATDLQRLWKPWARVESVKRMITCLLIIDAMYASLWGTAGVVELDKLEIIAPCKSSLFEAPNAMTFSQEVEKTNAQIIMPRMTLQRMSMLSSAMLGSMGLQALLAAISLQHSVARHRLYPGQLDSSSSGGGGGGSEETQASSTAPVERYALDEHAKNIAPLLAAIPSSRSDYFDREHPHALLLWNGLCMSTTADMDQFELALGRKGAVSAQSALANITAWAKSPAARRAALHASQIFWILSQSRVSEPALLLHEHMIFTAALVLAFYVFKATTTPSTPPSSEQGVAAAAAAAVALGSPVAANLELLQEIDWAEVGTEGLGGATSQVGYCSSATKRFIRSGGCISFGALEAVGERAARKIILNYAHLLDEVAKWEGSEYCEALKAIGDFFKSDSTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFP4</accession>
    <name>A0A1C1CFP4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PDAT9</name>
        <name evidence="9" type="ORF">CLCR_02335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFP4"/>
    <dbReference type="STRING" id="86049.A0A1C1CFP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02335"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02097"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="516" mass="58437" checksum="AC09AC2DF72462FC" modified="2016-11-02" version="1">MKVVDTSSAEKTSLVAQIVAFVTSNFLLVAVLALVGRCLYKKYASPLRNVPGPWLASVSRLWKVWSTYNGHTELDHIALHKKYGPVVRTAPNEVSFGTCNAAKDIFAVGKGFHKTMFYSVFPPKHAPDIFTEVREWKHAQMKRYAVVPYSLPQMQKRSEPIESMIKLLMEHLEKYATDNKRVCNLGNLLHYFAFDVLGEVAFSRQFGFLEQEVDVEGSIKNIDDVQWYDGIVGHIAEYDILLRNNPIRQYLPKKFQMQPTTMTKIAVAELEKRKQKDGSFDSHGIDLLAELLRAHEGNAEKFSINDVFSIAHGAVFAGSDSTASTMQSFFYLALNAPKVYAKLTKEINEAQETGKLSEIVTYAEAQALPYFQACLKEAMRVRPAVGLGIYRKTPPEGVEIDGKYYPGGIEVAVNGWVLHRDAAIFGDDVEEYRPERWFERDAKLMGSHLYQFGGGSHLCIGRNLALFEMNKTLIQILREYDVTLVHPGRPLQYHSTFFVVQEGLEVYLRKRSDKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFT2</accession>
    <name>A0A1C1CFT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMODS and SLOG-associating 2TM effector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02588"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02106"/>
    <dbReference type="eggNOG" id="ENOG502SRNI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4472872at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041622">
        <property type="entry name" value="SLATT_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033635">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793">
        <property type="entry name" value="SLATT_FUNGAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793:SF3">
        <property type="entry name" value="SMODS AND SLOG-ASSOCIATING 2TM EFFECTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18142">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="SMODS and SLOG-associating 2TM effector" evidence="3">
        <location>
            <begin position="84"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="266" mass="29393" checksum="7D2D08D7C73DC41C" modified="2016-11-02" version="1">MDPSARETGDDRGEAIHASASTPPQPQTAPAGTHDGVPQPSQQQSDTHAAHRTTQTAPQSVEPTFFGQIAGTDGPHQYESLRLRVTRAYKTHTYQYWFVAILSNSLLFLQIVIAASLTALGAFNNRRARTATIFLGASNTVIAGLLTYFKSRNQPNRARQFRNDLAAVVVQLDDTEANFRNPTWQGDESAELQKIRDAYKQARLDAQANYPDLWVKGTSPYNPNYTPPIQTDPKRGVSGLPSQLHRHRVQNWSPPGPSAPHRSRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGW8</accession>
    <name>A0A1C1CGW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAS/PAC sensor hybrid histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_03288</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGW8"/>
    <dbReference type="STRING" id="86049.A0A1C1CGW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03288"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04579"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="470"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="856"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="980" mass="106947" checksum="D43F192EBD5D44B8" modified="2016-11-02" version="1">MDQVQHEPALRRLQVHWDGGLIAASIAVSLLGAFTSTQMMCQARTSRYLSGVLVWTILGSLTFGFCSIWSLHFIAMLACELPLLIGLNVPLTVLSAFLAVTFTFLALASDLMRERYLSLVKRRRQLARRQNKKGAARVLNGSTDALLGPRTSESDHEPLTVPGQMHDTGNHGIIRYEGGASMTLGPLEDHFAVGKPANVATTEAPPSPHRPASPPISAWRRPLLVLNASLQEESSSNDTESLPWSSDEESRARGSPSPSHSDSSSLGLPGFMSFKVPRSTALKTTNVLVGTAYLLYHGATLRHLVKGFIWSLAITSMHYAGILALKIPEGHVTLQPFIVLLSAAISWLVCTIGCILIPQIEVNLSQQLIFSTVAAAGVAAMHFTGMWATTFWSRAPETTKHGYPPNLAVAVTSIAILTCMLANGLLAHSATVARNKLAEIVQTKRKLWAAIAQKENAEAAAAARSEFIASASHEIRTPLHQLQGYSDLMSRTELNEEARLLLLAIQQATRSLSMITANVLDWSRLEKGEAVCRPTSLDLRKVCESILTILPNKDEEAGTELMIVVGPNVPHSLFLDETYLQRILMNLLTNALKFTQSGYVILLVEIKDGELVVTVRDSGFGIPESFLPHLFEPFKQAQIRGAHRGTGLGLAIIRQLLQKMEGTITVESRYQQDEEVGAESSGSTFTVTIPVTVSADLPDSLGSLGPNRSIALFDSCSERTLEGLQLAWKAFGFDLVRAKPQDAISDSWGLVWTDLMFLRANEQLLRRLLEVRHQLVIVSYDSQTLLDESFGSVPPRHIVPIRRPLMWHRMVENIITAARTGRAAIDRSVRFAPVVDVVENGSSSPARETQTLSGSTVLLVEDNKINQKLGVKMLKTLGYDVVVADDGQDAIDKLVANDRDIAVILMDQSMPRMDGITATKKIREMEQSGGLSGKRRPIIMVTAVVGPDAQALCMSAGTDAFLPKPLALTKLDNTLKKYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH09</accession>
    <name>A0A1C1CH09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cpdS</name>
        <name evidence="8" type="ORF">CLCR_03415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH09"/>
    <dbReference type="STRING" id="86049.A0A1C1CH09"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03415"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04542"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000118">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008448726" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="533" mass="58719" checksum="DEC202B4342534AB" modified="2016-11-02" version="1">MRFSIAAVALGLLSLASAKRSPQHVGKTLPEIKRSVVPQSRSAAPKLEERAAPHLFLNDNTKKYAVNGSAIPDVDFDIGESYAGLLPISNGTNASELYFWFFPSINPNATNEIVIWLNGGPGCSSLEGFLQENGPFLWQYGTFKPVRNQWSWTNLTNMVWVEQPVGTGFSQGTPTATSEADVASQFLGFFKNFVDLFSMQGYTVYIAGESYAGYYVPYIADAMFNADDTEYYNISSIMIYDPSLSYDVVQEHIPVTAFADYWLPLLDLNATFMEQLHNMSDTCGYTSFMNDNLVFPPKGPLPTPPNVDLSDDSCDTFDAVFFAASAINPCFDIYQVATTCPLLFDVLGFPGSFDYLPEGASIYFNRTDVQKAIHAPIQEWAECTNVDVFVNNTDNSPPSALSVLPRVIERADRTIIGHGLLDMILIYNGTLLAIQNMTFNGAQGFSVPPSQFDDFYVPYHVEYDSQLGSIAGAGVMGQYHTERGLTLVTVQLSGHMVPQYAPSAAYRQLEFLLGRIPDLGAVGPFTTMQDSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHL0</accession>
    <name>A0A1C1CHL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_04401</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHL0"/>
    <dbReference type="STRING" id="86049.A0A1C1CHL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04401"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08114"/>
    <dbReference type="eggNOG" id="KOG3468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT47947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="106" mass="12217" checksum="A4CB0BB25F0540AD" modified="2016-11-02" version="1">MTVVESVKEVVGLGDGAANITGFNVTAPASRQAMSEARLPLAYRDSCAHLLIPLNKCRHDTWFLPWKCENERHSYEKCQYEEFKKRVAKMDEIRATRENEKRTSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHZ3</accession>
    <name>A0A1C1CHZ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_03943</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHZ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CHZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03943"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08304"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="615" mass="67534" checksum="EE2EC1970AC997E1" modified="2016-11-02" version="1">MPSPPKPPSTRPLKPAKEAPAAKSPSAKKKSSSVRVSAACEACKKRKTKCSGGPSPCQLCETLGTDCVIDLSLDMRRKAAFQRTIDESRNYQDALNTLLDAIREGPSHRLEALFDYVRSGATNQEITVAVQHQLIHAGDEDGDETMSSQADGVDSVLEDIKPGKSPADMSSFGSDSGRGRPADPGPIPISTLLSSLKNCSESQGEAILRQFLAVKAGGKASLPSHLADGKSPGEVTGAGSCTYDRKVVVQNRVHGYSVPHLHSWRGRVLESHTASLGESDADPFPSFRFTTCTRDDTATDDGQFTHFEPPSRRFSEGGPPPHSDHSQALHSDSPSPATGLSRQSSRYPMLNTDISLSALTVASSPATPYLELVTNFPSGQVRQNEWDLCVAQEDHVTRLRIPRHLILPLVVPDDSPMSRTYTDYLFGARRMLESGVPASDVLGHSDRVAVDLFFRPRRANDKFDCASWACEVSRSYDTDVFVRLATACLLTHMMRWHLVPTQENYQRIPDMMKPTPTQCMIPHIGAIETIPLPPVRDAAINKLRDWLTPLIEAEWSVNWPHSVEMAVERDSLTGATVLTQRFHEHVTRYDNWSVAGRFLLSFPEVAGQIRLHEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ37</accession>
    <name>A0A1C1CJ37_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ37"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ37"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04459"/>
    <dbReference type="OrthoDB" id="3709982at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="93" mass="10903" checksum="EEB23EC8EC91764F" modified="2016-11-02" version="1">MERPTPKRIVLRFHEKHQFDEAAINQAFFASLDLRLADDYYSHLCPPDEDSAKMHIVLDIHAKSVPVVNLHTLPYRVFKVKKDGHLSVRLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ72</accession>
    <name>A0A1C1CJ72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endocytosis protein end4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">end4</name>
        <name evidence="9" type="ORF">CLCR_03826</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ72"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ72"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03826"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10289"/>
    <dbReference type="eggNOG" id="KOG0980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17007">
        <property type="entry name" value="ANTH_N_Sla2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000004">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000021">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="15"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="8">
        <location>
            <begin position="816"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="314"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1018"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT48559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1059" mass="119925" checksum="59AB845D6B111A11" modified="2016-11-02" version="1">MAYPALGTGTGRNIDMAKTESDLAINIRKATSIEETAPKRKHVRSCIVYTWDHRSSLSFWAGMKVQPVMADEVQTFKALITIHKVLQEGHPVTVKEAQQNVNWIESLARGAMGEGLRGYGPLIREYVFFLLAKLGFHRNHPEFNGLFEYEEYISLKSINDPNEGYETISDLMTLQDQIDTFQKLIFSHFRGGANNECRIAALVPLVQESYGIYKFITSMLRAMHTTTGDDEALEPLRTRYDGQHYRLVKFYYECSNLRYLTSLITVPKLPQDPPSLLAEDDEKPALPRRPAKEIEKPPSPVAKNGTPDNQKDIEDFWTKEAQRQQQEYEAEQRRLQQQWEDQQRQQLAAQQDAQRQFEEQQRLQAEQQRLAQEQLLRDQYAAQTQGRLAELERENLNARAQYERDQLMLQQYDHRMKALEEQLQQLNNNYQLQSQSKDDQITSLQEQVNTWRSKYEALAKLYSQLRQEHLDLLQTTKSLKLKAASAQEAIERRERLEREMKTKNLELADMIRERDRALHEKDRVQGSNREEVEKLKRELRLALDRAEDAERAKGSEISSLLAKYNREMADLEEAVRSKTRQLDDLRAKQGERSYDHEAALKEKDDEIEIYKSGMEQALEELEELKLGHGESDGALDTAIDEVIKTNVNKINDIIDSVLQSGVQRVDDAIYELDSPMQAGNQNATAPYVLSQVEKASASATEFSTAFNNFVADGPGSDHADIIKTVSVFAASMADVLSNTKGLTRFATEEKKGDELTNAARQAALSTIQFFRNLHSFRLEGLEPMQKSDVVINSNHDVLMKLQRLSKLADAFAPKGSKISTTGDLGDLVDNELTKAANAIEAAAQRLAKMKNKPRDGYSTYELKVNDTILEAAVAITNAIAQLIKAATESQNEIVREGRGSSSRTAFYKKNNRWTEGLISAAKAVATSTNTLIETADGVISGRNSPEQLIVASNDVAASTAQLVAASRVKASFMSQTQDRLEQASRAVGAACRSLVRQVQDIIRQKARDDGDREDYSTLSGHEFKVREMEQQVEILQLRNALEAAQGRLAEMRKLSYRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ96</accession>
    <name>A0A1C1CJ96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome quality control complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NEMF</name>
        <name evidence="10" type="ORF">CLCR_03821</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ96"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03821"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08643"/>
    <dbReference type="eggNOG" id="KOG2030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="207084at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000003">
        <property type="entry name" value="Zinc knuckle domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="8">
        <location>
            <begin position="577"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="9">
        <location>
            <begin position="999"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="466"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="749"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1112"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="362"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="767"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="783"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="831"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="845"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="871"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="891"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="931"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="961"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1112"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT48522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1141" mass="126220" checksum="AA88AF971DF62625" modified="2016-11-02" version="1">MKQRFSSLDVKVNQNIPLHTLPLSFLTHFQVIANELATSLTTLRVSNIYDLSSRIFLFKFAKPGKREQLLVDSGFRCHLTSFSRTAASAPSAFVSRLRKYLKSRRVTAVSQIGTDRVIEITFSDGQYRLFLEFFAAGNIIVTDADLNVLALQRQVSEGQEDVDVKLGSKYTLEAKQNFRGIPPITEDRVKTALEKAVQRAKLAQEVGGKKAKRAKGGDDVRKALSDGFPELPYHLLEHVFIETGADSSQKADAVLASPEALQSAIKALQRAVEIFNSLDADHSKGYIIAKAKAAPSTQEQTQTETQPSDQREVSRDNLLYDDFHPFRPAQFEKKPGLHILEFDGFNRTVDEFYSSIESQKLESRLTEREEAARRKLEATRTEHEKRLAGLQQVQDVHVRKAQAIEANTHRVEEACAAVNGLIAQGMDWVDIGKLIENEQKRGNVVAQMVKLPLKLEENTVTLLLDEPSFDEGYESDEQDVTDDEEAESDDESATMNRPSAAERRLAVDIDLALSPWANARQYYEHKKLAAGKEKRTMEASAKALKSAEQKIESDLKKSLKTEKAVLRPARKQFWFEKFLYFISSDGYLVIGGKDAQQNELLYRRYLKKGDIYVHADLQGASSVIVKNNPRTPDAPIPPSTLSQAGALTVCTSSAWDSKALMGAWWVNADQVSKTAPTGEYLTTGGFIIRGHKNLLPPSQLLLGFGVMWLISEESRANHGKHRLERTESMLSGEAEALANDARGLSIDEQDVESEVEQDGQPEQAIPDVEEAADDAAEEENEDDRGVDLDEAHKTVTEVDEGGENHDSSAPSEAEDERSNPLQVQGAGVGEDTPKDNPDVRISADRDDEEGEQDDDDDDEHEDTQDTPEEATLSTRPSTPASPSNAVSAKPKPAHLARGKRSKAKRAAKKYADQDEEDRALAMQLLGSNRAQEQRKEAEADKAAREAKAQADRERRKAQHAKASDRERARRERLEKHADAGTAVLDEEDELSKEQLEQERQELMSIDRLVPAPEPGDELLAAIPVVAPWNALTRQKYKIKLQPGSVKKGKAVKEVLGFWTSLGTRGPKVVDENNRERERVWRREVELLKEWRVEEIVGAVPVKGCRIVQGGGLGGSLGGSSGGGKGKGSGGGKGKGGGKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJX7</accession>
    <name>A0A1C1CJX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CLCR_04859</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts (via SH3 domain) with PEX14 (via SH3-binding motif); forming the PEX13-PEX14 docking complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxin-13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJX7"/>
    <dbReference type="STRING" id="86049.A0A1C1CJX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04859"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03157"/>
    <dbReference type="eggNOG" id="KOG3875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10037838at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11771">
        <property type="entry name" value="SH3_Pex13p_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000128">
        <property type="entry name" value="Peroxisomal membrane protein (Pex13)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="291"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT48742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="445" mass="47435" checksum="56E4D0CAB6FF7F3C" modified="2016-11-02" version="1">MTAPSSDAPPSATPALPDRPSTLNSVVNQNASNFTNQNRFGMNSSPYSSPYSSYSSPYSRFGGGMGGGMYGGGMYGGGGYGYGGGMYGNNMYGGGYGGFNPGMDPNNPNNQSLTQTWNQSTAATFQIMESIVGAFGGFAQMLESAYMTTHSSFFAMVSMAEQLGNLRQTLGSVLGIFTLLRWMRTLIAKITGRPPPADATALTPAAFSSFVSGNGNAAPATLPDGSPAPARPSKKPFIMFAIAVFGLPYLMGKLIRAMARSQEEELRRQQQAGALTYTTNQNGEQVPIDPRKLDFCRVLYDYTPTPQSGGMDLEVKKGDFVAVLSKTDPMGNASEWWRCRARDGKMGYLPSPYLEPIQRPAPKTQAQITEGGQTASAPGSRTQTMKAEGPAQKLLEQTDRTKSLSSIYAGTSGMNKVPLPAMAPELKGKPGDISVESFQKSAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJZ9</accession>
    <name>A0A1C1CJZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily MFS 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_04778</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJZ9"/>
    <dbReference type="STRING" id="86049.A0A1C1CJZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04778"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03059"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="546" mass="59340" checksum="266A34CF4328B827" modified="2016-11-02" version="1">MARHDVETRPGRPPAPPSWASIPNKFQLFIICSVRVVDFFQQAALQAYMYYQLKSFSPSAPDSQISFEAGVLQGVFTLAQVFTGILWGRVADSPRFGRKGVLLMCLVGQGMSCVGVAFSRSFTAAAVWRCLGGAVNATVGGARTALAESTEKKYHSRTFLLLPLAWNIANIFGPLFGGLLSDPVQNYPALFGENSTFGGAHGVSWLTTFPYAPPNLFCALVLFADALLVWMGLRETLAAKRYDRDRGIEFAENLTYRIRNMIFRRFGYSQLRQADAPAGPDTLDDENLPSSTPMTPRPPKEVDNSSSAETSSKVPPRPSDAPNSAPPFYHAITSNVLLVLATVAVMDFQMGGFASLWTIFLSSARATDEQKSTVHLPFVFTGGLQFSLPTIGLAMSILGFVGIILQLTLYPSVNARFGLVRSTRWSLFVFPIAYALAPYLSLLISHPFILWIGIVVVVVLQVAARTFAIPGSVLLINNSSPSPAMLGTIHGMGAATSSAFRTIGPIVAGHWYGQGLEKGVVGWAWWWLAFVSVFGVVPSFWAKDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKY1</accession>
    <name>A0A1C1CKY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04790"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="295"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="518" mass="57164" checksum="E389EC3CE5423767" modified="2016-11-02" version="1">MSHAPQPGSGSVRPARLSATEKDKAPRSDGPTSTKTQAGTTLQRTHQKAPGDDLRRPQSETQSNERSLAFCSRTAVPNKSLSTGSAPAETSSARSRHIAQAARRRNSVQSASSVPPSLTRDTTSPASDAALTQCYHSPHGEPPQASKPGRLKGVNAHLETPKEEGDDDGDGGDDDDGGESHTPIEAFFPQLKEFMNHIHPIAAGLQKHSAGDYATITLPTKTVAAFHRAATLFLDQENLCVRRVEPSETATDVLRTPLLFPQYVEHDTDLDGSLPNHDSISFGHIDADLDPLKLLEQVRDGIEQFRTELGELQLDRDELLNPTEDTAMQDAPLMLQEIDIKRAEQQANLDAALRQEQDLSAKIQELGLSHSSGYSLEHSAAVEDAQTSSTRNAPVEYPDDAPRRIRRYTAEASQQMGASILPALGSPRDLIGVGQIKTMEDVVADTKHLHVVVRRYEEELLEVEEHYVQLRKEQEERNAVGSQLLDVDLHHMNSYWQRRVQIESRLDSVKRQLRRGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL26</accession>
    <name>A0A1C1CL26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_04784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL26"/>
    <dbReference type="STRING" id="86049.A0A1C1CL26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04784"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02783"/>
    <dbReference type="eggNOG" id="ENOG502SH94">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008448728" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="29"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT49142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="542" mass="57169" checksum="CF048CB3C9E5FEA8" modified="2016-11-02" version="1">MSSLRRTLQPLAAVFACLYFLAIATSVAESTPCDRLTKPTIPGATVISIQSQHLPNASVLASPPLLNTNVTGLDICSVDIVLSHRDANDTVKVKVWLPSTGWNGRFLGTGGSGYAAGFFELSLAPVVTLGYAAASTDAGLSGEPYTPAAWALDGQGNVDKALLLNFASRSVHDMAVAGKAIATQYYGREPHHSYWNGCSTGGRQGLMAAQTHPEDFDGIVAGAPAIDWARYVIAEQWPQVVMREEGIYPSRCLLQAFTNASIAACDSLDGLADGIISSPQACKFDAHAMVGSTFHCEDGQEEETVTPRIVSVLAKIVAGPKGPTFTHKYALYAGAALDSLANTTTDSEGKTVGYPFFVNDAWIKYFVRKDPNFDTTTVGYASFAQLFTASQHEYGALIGGYNPDLSRFRAAGGKAIVWHGEADQLIFPAGTVEYHRMVERVVGHGNASAVAGFYRTFLAPGVDHCGAGALTGTSPGAVPVDPLAAVVAWVEKGVAPDVLDASIQSVGDDGVVVTRTRNLCPFPSRSRYRGGDAAAEGSYVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLD9</accession>
    <name>A0A1C1CLD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">stt3</name>
        <name evidence="23" type="ORF">CLCR_04592</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLD9"/>
    <dbReference type="STRING" id="86049.A0A1C1CLD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04592"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02667"/>
    <dbReference type="eggNOG" id="KOG2292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 23" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="21">
        <location>
            <begin position="24"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="22">
        <location>
            <begin position="544"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OCT49271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="751" mass="83798" checksum="9C2999A3AF5CF809" modified="2016-11-02" version="1">MAASTHLDPLFRGSASKNTRGLLRVTILLTIAAAAVAARLFSVIRFESIIHEFDPWFNFRATKYLVKNGFYSFWDWFDDRTWHPLGRVTGGTLYPGLMVTSGVIYHVLRLLSLPVDIRNICVLLAPAFSGLTALAMYLLTSEMSSSPSAGLLAAAFMGISPGYISRSVAGSYDNEAIAIFLLVFTFFLWIKAVKNGSIMWGALAALFYGYMVSAWGGYVFITNLIPLHAFVLILMGRYSSRLYISYTTWYALGTLASMQVPFVGFLPVRSSDHMAALGVFGLLQLVGFFNFLREQLPGKQFQTLLVALGGAIVGLMFLALVGLTVSGVIAPWSGRFYSLWDTGYAKIHIPIIASVSEHQPTAWPAFFFDLNMLIWLFPAGVYMCFRNLKDEHVFVVIYAVLASYFAGVMVRLMLTLTPVVCCAAALALSHILDTYLYIPTPSEEPADGSNGSAKASKIAANPSLRSIRNPLIGIYSILSKSVITSMMTGFLLLFVAHCTWVTSNAYSSPSVVLASRLPDGSQHIIDDYREAYYWLRQNTPQDAKIMSWWDYGYQIGGMADRPTLVDNNTWNNTHIATVGKAMSSREEVSYPILRQHDVDYVLVVFGGLLGYSGDDINKFLWMVRIAEGIWPEEVKERDYFTARGEYRVDEEATPTMKNSLMYKMSYYNYNNLFPAGQAQDRVRGSTLPAQGPELSTLEEAFTSENWIIRIYKVKDLDNVGRDHQSAMAFEKGHKKKRKLGARKGARVLRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM53</accession>
    <name>A0A1C1CM53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rhlG</name>
        <name evidence="4" type="ORF">CLCR_07451</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM53"/>
    <dbReference type="STRING" id="86049.A0A1C1CM53"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07451"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09842"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G14540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="283" mass="29003" checksum="5F7F550168A7B93E" modified="2016-11-02" version="1">MGSAQLDVELKDFGSIFSLEGKVAVVTGGSRGLGLNAASGLMQAGCSKVYITSRKAKACEEAVAALNSLPNKRPGAVAISVPADSSKVSEVERLAAEVAKTTDHVDILFANAGATWGAPFETHPESAFSKVMDLNVKSVFYTVQKFAPLLQKRATIDSPSRIIITASVAGLGVGTLGENATYAYSASKAAAVHLAKNLAVELGPRGILTNAIAPGFYLTKMASGLIDLQGGAAALAAEVPNKRLGHPEDIAGLVVFLSSRAASHINGAVITTDGGSLLSRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CME6</accession>
    <name>A0A1C1CME6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CME6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07288"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09924"/>
    <dbReference type="OrthoDB" id="4159380at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="331" mass="36081" checksum="5328C1F475E79F69" modified="2016-11-02" version="1">MPVHHGHSEVPRAGNQLPLAAGILPSAGLHDTINCREHASEQGFLPISDDGSPEEILHESPASSSYAAGEPGPAIDVDWDGPFSSEELDYFRSLPEQDLKAIYPYGIRPPANLGPHTPFDRYDQFHRALLNLAAGVSLRDVMRNGDFEIDGKQFVMHIAIFCVKSLGYTDQDLSTLGVHLSGLGYTAAASSDDDGDHDDGTNISHSPRAEAFSDLPGDRDENQQEDVTEGTTNRKSQTGAVEQSEITPPIDQSVKSPERSSSKHDPPNERLQQHDLPSNAVRLGTVALSTSFKFLLTVWVRYAVLIMIICFSYESLVRPQFASCSNSARQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNE6</accession>
    <name>A0A1C1CNE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein-lysine N-methyltransferase EFM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNE6"/>
    <dbReference type="STRING" id="86049.A0A1C1CNE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07242"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08930"/>
    <dbReference type="eggNOG" id="KOG2497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="41095" checksum="6395078D116BB9B9" modified="2016-11-02" version="1">MSPFGVVDSSRGIDSGSPTGGSISMDIARAGVEPVVVKFYRQYMQQINELSYPPGSLLLAPDIQTCLYKYFFDASQNKFLPPPRYQTKVLRQIIREIEKTIKDAEEEQVSDQLYEHLGYLSAIPLQDSSEEAQELRVHSYYPPLPFDQPGVQPILIKEAHNLLSKGNNVGLRTWEGSLHLAWYLTAQRPELVKGKNVLELGAGTGLLSLLCAGHLHASSVLATDGLAHVCECLEANIELNVQNSTLQNGRPPQVLQLDWTDREAIDELVQNVKSSDASYDLVIGSDITYHPDILRPLAQILSTLKDCSPEAVILISAAIRSDTFWQFTTICRDEFGFGVVEEDVHIPDGLQYSGFFHSVITPIKVVSLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNH9</accession>
    <name>A0A1C1CNH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock protein sti1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sti1</name>
        <name evidence="9" type="ORF">CLCR_06860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Part of a larger complex that includes HSP70, HSP90, and immunophilins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNH9"/>
    <dbReference type="STRING" id="86049.A0A1C1CNH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06860"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08967"/>
    <dbReference type="eggNOG" id="KOG0548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000004">
        <property type="entry name" value="Putative stress-induced-phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="138"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="333"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="530"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="582" mass="64326" checksum="C7CB14B99FCD1D93" modified="2016-11-02" version="1">MADALKAEGNKAFAAKDFKTAVDKFSQAIELDPTNHVLYSNRSGAYASLRDYQAALDDANKTTELKPDWAKGWGRKGAAQHGLGDLVGAKDAFEEALKLDPSNAQAQQGLQAVNRAIEAEARADGADPMGGLGNMFNDPQLIQKLAQNPKTARYLADPQFMGKLQQLAKNPQDMGQALGDPRFLEVMGVLLGVDMQMGMPPEDGSSARPTEAEEDVPMPDARPQSRPPPQAETKAPEPEPEPEPEDEEAIAAKRAKEEADKEKALGTENYKKRKFDEAIEHYSKAWDLHKDITYLTNLGAAQFEKGDYKGCIESCEKAIEEGRSMLADFKIIAKAFGRIGSAYEKLGDLPKAIINYQKSLTEHRTPDILAKFKAAEKAQIKAEKDAYVDPEKAEEARLLGAEKFKNADWPGAVEAYTELTKRAPDDPRGYSNRAAALIKLLAFPTAIQDCDEAIRRDPTFIKAYLRKAQALFGMKEYNKCLDVCTEAMEHDTEGKNAREIEQQQQKALEAMYKAREGETEEETSSRIQRDPEIMKILSEPVMQSILQQAKSDPAALNEHMKNPGIRSKIQKLIAAGVIRVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP91</accession>
    <name>A0A1C1CP91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP91"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07024"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05670"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="526" mass="59226" checksum="37D6B5B8A625C1E5" modified="2016-11-02" version="1">MVLEQTVKLTFLPWSGKGKKHRSEERLQSSLRHQHTALAGHRRQREHKRTLRDKANSQAAITPSNSPVQLSDLGSDASWSLTRSATPATSNHLSNDLERFPSPITLLGTNLFDSFRFRGDVKLSKELQSVLHDALIHQWPAFALGTNEHAVMEVRRAAFTTSTSSPHTLFAIIYAGACYRSYFKDAMPGDNLLQLQAKQQALAHLREAVQQADGKPTDEMLMTIALLAIHGSVQPSKPPRFTAPLYRDNEFYSNVKFDQTHLRALRTLVGQRGGLKKLGIHSLSNIISMIDTFQSLMCLNKPRFEPLYSTSALSAVLQETWDDVTWTRFGKQEDGFQFLDNYEEGFRLRRVIRQTRVLLETYSLCLRNPRQAPDLMVAVHTRRSLQHAALSLDHRAGCLFEAARLATIIFLAELGWTLPVVGGFQDTATALLLRALKGCGVQQCWETHPDFLIWATVMGGLAAHQTPRLRDFAELLGEASMPVTKDSWLQVKSLSLRFLPFEYELTGTCHAFWDEACDLLSSELET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPT7</accession>
    <name>A0A1C1CPT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cleft lip and palate transmembrane protein 1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CLPTM1</name>
        <name evidence="8" type="ORF">CLCR_06798</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPT7"/>
    <dbReference type="STRING" id="86049.A0A1C1CPT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06798"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05482"/>
    <dbReference type="eggNOG" id="KOG2489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="595"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="650" mass="73536" checksum="4B2E31E8D5A779FC" modified="2016-11-02" version="1">MPDSRTGGAPAAGRQEAGGKGVGIFMLTQFVVNQFFGSKTQSTGGAGTNLKQNVNFEDRADVTALTNYSQIPHNIAPLWPDNSVVDIQMYVNPQLTLPPLSTLPKENLVLDEKSFRIGNYSENREVNTHIAIPKEVQHNGTLWAHFFVALAGNELDPTSPSYDPYKAEYFRKPLNQYLPKKKARKLKNLLDKSESVVEEDAEESTGPQIASYYHPNFTVAVIPNTGIQNWRQMHPAVRKNIVLEPTGQRDSTGQNGWYYPVIFLNTFWQLRSHMTELNDTVTSMPLNINLYNLANWKYSLLASIDEGMKQNAQQAASGGPMPASGDGSEFEKFKEILLDTNAYLLGTTFVVSILHMVFEGLAFKNDISHWRKKKDNVGTSVRTILANVFMQAVIFLYLVDNSENTSWMILASQGFGIVLEAWKITKTVDVRLREPGPDSSFRGLLPYVIVFEDKHKLSETEKKTQEYDQIAFRYLYIIAVPLLLAYAVYSLIYESHKSWYSFIIETLVGSVYAYGFLMMVPSLYINYRLKSVAHMPSKALTYKFLNTFIDDLFAFTIRMPLLHRLATLRDDVIFFVWLYQKWAYKVDYTRVNEFGQGGDDEDEEHEDNDKKVDGETKKILAGQDTKELKPSAPVSRASGAQANAGAKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPZ4</accession>
    <name>A0A1C1CPZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Finger and ankyrin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_06834</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPZ4"/>
    <dbReference type="STRING" id="86049.A0A1C1CPZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06834"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05433"/>
    <dbReference type="eggNOG" id="KOG2505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VLRF1" evidence="15">
        <location>
            <begin position="237"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="593"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT50580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="649" mass="71861" checksum="FCFD268F984EAA89" modified="2016-11-02" version="1">MADTSQAETNPLLRRPLYIYDLPPELLFTLTVAGKEHSQPPDHTPPDEPTVRRTNNNEDGVTNSTSCSLCKVIFNSVQDQRNHVKSDFHRYNLKLSIKQQPLVDEATFVRLIGDLDESLSGSDSDDSEDENDDGLKAGDSTLTALLRKQAKISHQEADGETEGSGKRGYGNAPLIWLSSPKLGDDVRLGVYRAILSSEEQEQAPTSLVDIIQKKQLKPVPAKLSGQAQKDAIQAAQSDPHFFLCMIGGGHFAAMVVSLVPELRKGPGGVEERHAVVKAHKTFHRYTTRRKQGGSQSANDNAKGNAHSAGSSIRRYNEMALEADVRAVLHDWRATIDTAELLLIRATGSTNRRTLFGPYDGQVLRSTDKRIRGFPFSTRRATQAELLRSFQELTRLKVSKLVEPAPEKLAPEKAPKERKAKPQAPKLSKEEEALQFHTSQLQALIRRSKAPGVLLYLTKNELSPDFTFFPAAEHRHAPTPLHLSASTNSPALILALLTKARANPTIRNDDGKTAYDIAGDAKTRDAFRIARHQLGENAFDWAAAHIPAALSQEEVDAKAAQEKAISDAAEAQRRKADLERLRQEEEKRSVTRIERKAGAGKTLAAAVEKTGAEKREEEARGLTPEMRMKLERERRARAAEERLKRMQGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRA1</accession>
    <name>A0A1C1CRA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">tor</name>
        <name evidence="22" type="ORF">CLCR_07877</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Vacuole membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRA1"/>
    <dbReference type="STRING" id="86049.A0A1C1CRA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07877"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09667"/>
    <dbReference type="eggNOG" id="KOG0891">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905356">
        <property type="term" value="P:regulation of snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000020">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000582">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="repeat" description="HEAT" evidence="17">
        <location>
            <begin position="988"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="FAT" evidence="20">
        <location>
            <begin position="1252"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="19">
        <location>
            <begin position="2002"/>
            <end position="2331"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="21">
        <location>
            <begin position="2465"/>
            <end position="2497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2323"/>
            <end position="2344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OCT51029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="2497" mass="280166" checksum="CB20DDE346B3F153" modified="2016-11-02" version="1">MAQQGPGPDPSERIFTDLRSKNDEVKNKAAAELRDLITLLSREWSPERFSTFYDKVTTRISNLIVQAPDASDKVGGVLALDRLIDCDAIDPAQKASKYSNYLRAALKSNDYTVLDAAARALGHLARPGGAYTAELVEAELTSAFEWLQPETKQESRKLAAVLLIRELAKNSPTLVYGFIPQIFDLVWNALRDPKDLIRRVAAQSVSACFGVMVARDAQFQNHWFAKIYSKTLEGFRPNTTVDETLGSLLILNELLQQGNMFMHDFYRNACEIVLRFKDHRDPRIRTQIVQVIPVLAEYAPLEFINNYLHKFMVYLQAQLKRDKERNQAFVAIGQIANAVGSAMAQYLDGIILYIRESLSAKTKNRAAVDEGPMFKCISMLAGAVGQTLSKYMEALLDPIFACGLTEPMEQALEDMAHNIPPIRATIQDKLLDLLSLILVRSPYRPLGCPPNTIPPLPSFAKDYGGMPAEHKDHEITLALKTLGKFDFSGHILNEFVRDVTLRYATNENPEIRRAAALTCCQLFMLDPILHQTSNNAIQVVGEVVDKLLTVAVGDPDADIRVTVLRALDKKFDKHLARPDNIRCLFLAVNDEVFPVREAAIEIIGRLTTVNPAYVFPPLRKLLVNLLTGLGYSNTAKQKEESARLISLFVSNATSLVRTYVEAMVSALLPKATDSNPGVASTTIKALGDLTSVGGEEMVRHIPELMPIIIDALQDLASHEKREAAMKTLSSLAINSQYVIDPYMDYPELLGILINIIKTEAHEELRTDAIKLVGVLGALDPYKYQQLSESVAGKQSKAETQPVSDVALIMQGLTPSNEEYYPTVVINTLMQTILADHTLVQYHSAVIDAVVTIFKTIGMKCVPFLGQIIPGFLGVIRSSPPPRLESYFNQLAVLVNIVRQHIRAFLPDIIEVIREFWNVSRQVQSTILSLIEAISKSLEGEFRRYLAGLLPLMLGVIENDSDLRRESSIRILHTFLVFGSSGEEYMHMIIPAIVRIFENPAAPPNARRAAIDTLGKLSRTVNVSDFASLMIHPLSKILSSPEKVVTNSSERSLKSAALDCICALIYHLGQDFAHYLPLVERATKAGQINSDRFQKLIENFKSGKALPVDFYPEEQYGSTAEETTYANITSMRLPVNQQHLKNAWDTSQKSTKEDWQEWMRRFSVELLKESPSHALRACASLAGVYQPLAKDLFNSAFVSCWTELYDQYQEELIRSIEKALTSPHIPPDILQTLLNLAEFMEHDDKSLPIDIRTLGRFAAKCHAFAKALHYKELEFEQDQNSQSVEALISINNQLQQSDAAIGILRRAQVFGEVELKEAWFEKLQRWEEALSAYQKREKIEPENFDIVMGKMRCLHALGEWKILSEIAQEHWNSASTENRKNMSALAAAAAWGRGEWDLMDNYISVMKESSPDRAFFGAILAIQRNNFTDAQSFIVRARDGVNSEITATVGESYNRAYSVVVRTQMLAELEEIITYKQCEGNSEKQESLKMLWNKRLLGCQSNVEVWQRMLKVRALVLKPTDNADIWIKFANLCRKSERIGLAERSLSSLGGGGNLAANLVDAPPPVAYARLKFTWATGHQETALTALRDFTARLADDFQQTNTALANATHNDRLNNMNGLDMNGHDLLAQRRKREELERCSKLLGKCYLRQGEWQSFLLRGDWTSPRAQEAVGDILNSYQLATQYNETWYKAWHAYALANFEVVTSMASHTDQDKVRNLPEQVIKTHVVPAIAGFFRSIALSKTSSLQDTLRLLTLWFAHGGHTEVNQVVVEGFTSVSIDTWLEVIPQLIARINQPNVRVRAAVHRLLSEVGKAHPQALVYPLTVAMKSSVAQRANSATQIMETMKVHSPRLVEQADLVSHELIRVAVLWHELWHEGLEEASRLYFGDGNVDGMLATLAPLHELLDRGAETLREVSFAQAFGHDLAEARAFCNAFRRSKEIGDLNQAWDLYYAVFRKIARQLPQLMSLDLKYVSPRLKDAHDLDLAVPGTYQSGKPITKIVSFDHVLTVIPSKQRPRKMTLKGSDGVSYAYLLKGHEDIRQDERVMQLFGLVNTLLNNDTESFKRHLNIQRFPAIPLSQNSGLLGWVPNSDTLHNLVKDYRETRRILLNIEHRIMLQMAPDYDNLTLMQKVEVFGYAMDNTTGKDLYRVLWLKSKSSEAWLDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRITGKIIHIDFGDCFEVAMHREKYPERVPFRLTRMLTFAMEVSNIEGSFRITCENVMRVIRENKESLLAVLEAFIHDPLLNWRLNTRESPARPHFRSERRQSIIDVPGGQHEDYDRSPMENAHNPAAVAQGTSHVGAPPGRRPRRSSILDPAMGGGSVLDKIIDSNNTAAQEAKEVQNARALQVLARVKEKLTGRDFKPAAPGTQSYAATQALRADLNGLGLESVMNGSNGAMNNITNGAIDPRNGMDDLGHMKQREVIAGTAPETTMAGIGGLGVSEQVDRLILQATNVENLCQHYIGWCSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRC1</accession>
    <name>A0A1C1CRC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome oxidase c assembly-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08823</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRC1"/>
    <dbReference type="STRING" id="86049.A0A1C1CRC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08823"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09670"/>
    <dbReference type="eggNOG" id="ENOG502S3II">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4205486at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029208">
        <property type="entry name" value="COX14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14880">
        <property type="entry name" value="COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="36868" checksum="F3EB16B0FA6B7CE2" modified="2016-11-02" version="1">MSRRPPADTFTRFTSTTPHATTFTYQPSARPTSRSTPSSSSPSPSSQSPSSQPPDPQSQPPANETPMEKVARLRAAHRATLASQNTSTFDRLISSGRNIADRAHRLTAYGLILFSGLAVCVTAYGTISLIAHSRRQKRAWIERELDRLDEARKAFLRGDATAEQLHLLEQERAGQEIEAARMKEAEKKKSEGVWGRVKGLVGGQLAKGEMGEETVQEREKRLTRKQRGGEAGWIEGEVQPVASATSPAATPGSVVRTAVQVAPSEIPGVGIDSKGRPVPAGRVEYLASKVAKEPTTGERTVTVRAGGPLDVMASNVAGAVAGSSSTEGKSWLSWIRGSASTKSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRJ1</accession>
    <name>A0A1C1CRJ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRJ1"/>
    <dbReference type="STRING" id="86049.A0A1C1CRJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09075"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06948"/>
    <dbReference type="eggNOG" id="ENOG502SRTS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2565331at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="8281" checksum="B08E68BF68ECAA95" modified="2016-11-02" version="1">MSQDQQKKQGGGVLGGLTDTVGNTVTGLTDTVGNTVSGVGEGLGKTTQGATKGLGDTTKAAGNNVKSGTDYVGGKKQTADNPLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRK4</accession>
    <name>A0A1C1CRK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_08350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRK4"/>
    <dbReference type="STRING" id="86049.A0A1C1CRK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08350"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06939"/>
    <dbReference type="eggNOG" id="KOG2417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="8">
        <location>
            <begin position="212"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="7">
        <location>
            <begin position="349"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT51129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="565" mass="60800" checksum="C456A74F75ED4ED4" modified="2016-11-02" version="1">MLPTYADDGCDECTPASMHPGRFTSKAAFSTLPFVATFAVLTIVAYRKVYPLLSQTSPASKSQDAPSGSGSGKGLPRPATAAPEPATQQLARRVAAITFASTIALSAVLTELLLCEISNSFNPTARSIALQITVVSLLGLLVVAIPLLGISSVVAKSGYKFRGEKKRSRAHLAWVLELAGYAAFLFGFWAIGALLPDAPTLTITESITRQSGLFQACLDRLGITGVSLMALLSGFASVSAIWQSFGPKARIVADTDITRKQAGLDATMDMLLEKKERLRMMESMSPATQSHHSPIQSFWSRTVGAVRKNTYDQQKDVLEMEASGLETMASSLETSLSILRARRVNQLKATTPTGRLSLAFSHIFACYCVYRICTTTINIIRRTLLSSSASTLSPSTSTTTTTTTTSDTDPVTYTIALFARHVYPSLDQASWAQQISFLLSGAMLLASFTAVTQTFHLFARFMPSVLHATKTNFALLISQISGMYVISSALMLRGMMPKEVGSVINTALGAGLLEPAWVQRWFDGFFMLAVVATAVGLYLGRHVSGAATWEDDAGWDLAMELGKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRR5</accession>
    <name>A0A1C1CRR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_09237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRR5"/>
    <dbReference type="STRING" id="86049.A0A1C1CRR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09237"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06904"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="41"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="111" mass="12022" checksum="CA3564A79B837909" modified="2016-11-02" version="1">MYRLGRRGLGPAFKAFRDTTVRSSIQQQQRRNLSIHEYLSANLLKSYGIGVPNGEVAKTPEEAEAIAKSIGGDDMVIKAQVLAGGRGKGTFDNGLKGGVRVIYSYAHPPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS38</accession>
    <name>A0A1C1CS38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pentalenolactone D synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">penE</name>
        <name evidence="9" type="ORF">CLCR_08207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS38"/>
    <dbReference type="STRING" id="86049.A0A1C1CS38"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08207"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06795"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000341">
        <property type="entry name" value="Baeyer-Villiger monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF4">
        <property type="entry name" value="BLR3857 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT51288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="654" mass="72858" checksum="0A56928934F80FB0" modified="2016-11-02" version="1">MADVKTLAPSDLLGPKPPQTALDSDISLAAKPKDLPFDPDALRNKYMEERDKRLKYGQAKGGIAQYRLVEHDGPFAHYLRDPWVQPGFTRDPVDEQVDVVIIGGGYGAQLVAVRLIEAGIDKIRIIEKAGDFGGTWYWNRYPGAQCDIESYIYMPLLEELGYMPTEKYARANELLRHAEMIGRHWQLYDRALFQTETHSMRWDDATCLWTTETNRGDTIRSRFVIPAAGPLHRPKLPGLPGIESFRGHSFHSSRWDYDYTGGDTTGNLHKLRDKRVGIIGTGATAVQIVPHLGQWAQEVYVFQRTPSSIDVRGNRPTDPAWAASLKPGWQKERMDNFNVIVNGGITDVDLVQDGWTDILHKLLARATPTTGDGEPVDPARAAAERQIADYEKMEQVRARADAVVNDPAVAAALKPWYNQLCKRPCFHDEYLQTFNRPTVHLVDTAGRGVDAITETGVVANGQLYELDTLIYATGFELSTEYAHRANMQIYGRDGCTITDAWKQGTRTLHGWTSRHFPNCFWVQIVQAALSPNFLHVTGEQAEHLAYVISECKSRGVVAVEPTLEAEEAWIDTILKMAKLRADFLAECTPGYYNNEGTADAAVAQNASYGGGAPAFLKLLKEWRAKGDLDGLDLRYGESESVVGPAAQEVIQANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS55</accession>
    <name>A0A1C1CS55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Receptor-activated Ca2+-permeable cation channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_07981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS55"/>
    <dbReference type="STRING" id="86049.A0A1C1CS55"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07981"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06748"/>
    <dbReference type="eggNOG" id="ENOG502QT9R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="346"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="868" mass="97862" checksum="DD527650A75215CD" modified="2016-11-02" version="1">MPAPRASASTNTQGGSSSTAPVSRTTSRNKLSSSPHFRLQRQRTETDALLAEQHDEEHFADSDGLYPPHCTWTSHDQAVSGGKPPESADPFGNGKCSVYENIHRIRRDITTSIDDPYSLEQLKAPRMNISVVRPLVDALYETQDLSIGPSYWPGYLLTRANKSKVYCLLVNRMQFIREQSFATHHQTVNLTRALLCELVAEKILRRYNEHNPGPRGLLKLANILVAGFEPFQGAPDEVIDQSKHAMHYWATQYRSQSGKVERKLTALEVAIVSASKSFLASSACQKVVDAIYRGKIVYTPSSFMDIIPDHWKKRPISLYDPRRAPLLNQYRLVVPRTRNLIEVLQFMVLLGLYIAVMVGRENRMTPKFEVVELVFDVYGAGWVLDQFASILEHGWGVYTQNLWSFLDVMFSTLFLVYLGLRLHAFSISNDDKSIAIARTALDVLSCGAPVLIPRLAFNVMSENMLFLSLRAMMSDFLTLTALAVWCFAGFLLSLKWLHAGAHEAGTIGKWMIWIWFGLDGTGIGQSTDFHWLLGPVLMVLFAFLGNTLFLTVLVSMLTNTFSGIVGNAVQEIQFRRAVLTFEGVKSDAIFAYMPPFNILALVILLPLKWILSDRIFHKVNVTAVRIINLPTLLLVAWYERRTLWMSDRHKGGRHKKIDWKNANGPKATPTQYWAISRFSVHGDIHAVFDIDPPQSVLDKIAEEDDLNHSDDMGILSNTRIKDQFAHLSEERRASQASDANRRLSVNPRAKKKRRRDSKVENTAKQDSQNDQKLKNEFRDSDDAGDENGAPSGYRKPKKGERMDSLVDLNSDGDRDVRILEALTRLHKIEGAMERMEALLGQLVDGDATSENSEGKEELAQELRSNSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSI4</accession>
    <name>A0A1C1CSI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative choline transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_08079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSI4"/>
    <dbReference type="STRING" id="86049.A0A1C1CSI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08079"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06628"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF27">
        <property type="entry name" value="CHOLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="518" mass="55508" checksum="00FBA5DB95A6D33F" modified="2016-11-02" version="1">MAATRNADDKKDPLPGADTTESPPDTGISELINASGHVQELERNFNLLSAAGVGLVVGNVWPAVGGSILLAIFNGGPPGVIYEFIAVSVFYWIIAASLAELASAIPSSAGVYHWASVTPGKSWGRIIGFYAGYWNWLAWVFGAASMSSILANTFVQMYALEHPDLEVQRWHVFVTYLIVTWLGCLSVCFFNRAMPYLNTIGIILILAGLLVTVIVVAAIPGSGSHPPHASSSFVWSEWSADIGYPNGFVFVAGMLNGAYSVGTPDAVLIVLLDSHIAEEVPNPGRNIPIAIGLQMGIGFITGLVYIIAIMYAISDYDGLFNAGFPLAEIYRQATGSAGGAIGLLVPFLLCITTCLVGVYITAGRTLWTLGRDKATPFPKYVSKVSPRFGMPLIATLTCGCLVTVLGCYIAAILPHLLTRRKNIVFGPFTLGKFGTVLNSIACGYMIVWFVIYCFPFALPTDAENMNYACLIWGGLTVFVTVWWLIGARKGYVGPKLAGGIDSPVEHMRKPSVEKRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSN3</accession>
    <name>A0A1C1CSN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_08176</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSN3"/>
    <dbReference type="STRING" id="86049.A0A1C1CSN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08176"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06591"/>
    <dbReference type="eggNOG" id="ENOG502S3SB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF95">
        <property type="entry name" value="BETA-LACTAMASE-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651027" evidence="3">
        <location>
            <begin position="31"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="4">
        <location>
            <begin position="82"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="5">
        <location>
            <begin position="451"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT51495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="677" mass="73399" checksum="A71ED9F5C1F11CF8" modified="2016-11-02" version="1">MNALRKQATMLLPLLLLLLFLVVPTPVVQAICPAQSPFYPPPTYDRHASEIWEAFSQIEASLSTLTRNNTTLFDTSSYSVEVTSSHRTLWSTFHTARDKNETRPGAVKVDSTSRYRIASITKVFTVLGILQLHGAGRVSLDDSVAKYVSFSTGTANSHSTANSGSIDWDKITLRTLASQLSGLPRDWAQGDLLTAPDDHTAMGLPPIPASAPERDNLPKCDSYEHYKPCTAHELLAHLQHRVPLFAPGRKSTYSNIAFELLGMVIANVTGMAYEDAITASILHPLGMNETSFVKPPDEVAVLPKHNAWYWDVDEGVQNPTGGLYCSAGDMSIFLRHVLTEYMDAGASKINWLPETSSSAGGSASWYAMPWETFRTEKILGGGDAASPSPPPSRSVTFFTKGGGLPGYTTIIVLVPEFDLGVTIFTAGDVELLGDLIEMITVPLIRAADKLAARQVVDSYVGEYDSFSSQAEEGADSEADASARAGVASLNSSLTLSYTATHGLEITRWISNATDMLGVFRAQFKLPKDRQFHAQLIPTLLYRESSNADRLRDDDQKEMNKGGGKGELWRMVVALDKPTTNPAGLGVWDDFCVADVDTKMYAGRPLNEVIFWDRNASSAMRQFGRVEMSAFRVNLTRVHGSGGGDGGGGGGGGKATTGEDLKLVAQDRRGISVEGRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSU7</accession>
    <name>A0A1C1CSU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08907"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="211" mass="23958" checksum="01FE4E28A7B235AC" modified="2016-11-02" version="1">MSRRLRGYPTEHVSWWQRSEIIQGIIEQFEQWRREKIAQVFRWAVLNGMFLRSVEYDLRVRGCAVVVDEANTNLPPLCGHISTTEPSESEDMLDAGILIGRGATWAGLPHVAGMLRGCLGVIPHRSWTLPHRSWDLGVHAELERLGHAHRVTVLVLGDLPCAGDGVPRTSTGNSVHESRKSRHPRSRCRFRHSSLSQRFRKFEAVIGNSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTE4</accession>
    <name>A0A1C1CTE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutathione transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_08000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTE4"/>
    <dbReference type="STRING" id="86049.A0A1C1CTE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08000"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06340"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="619"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="701"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="773"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="820"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="857"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT51760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="909" mass="102096" checksum="FF806D27C58C603D" modified="2016-11-02" version="1">MSRSLLLIRSSPALGTGSYGTVPLLNERSESDVDSEDELSHGHHISKKSRGKRIQSTGDLETEHGHFSDPRRRQQHQHQRGSQWARRRSSSGASEVGMGLDAKASFAPPIAEHKAESSNASTRTGSGSEVEPEYVPGADDPPDNSPYPEVRASVPATDNTALSISTPRMWILSLLFAIAGSATNLFFSLRYPSVAITPVIALVLVHPLGKLWDFLFKRADDQEQFFVEGSLQREDPRFGDTRLRQLRLWLAQGRWNEKEHACVYISSNVSFGFAFATDVIVEQHKFYKQDVPILYQLLLTVSTQILGYAFAGLTRRFLVRPAAMIWPGTLMSTAMFTTMHKDENKPANGWTVSRYKFFLYVWSAAFLWYFFPGLIMPALSYFNVITWFAPKNVVVANLFGVASGLGLFPLTFDWAQIAYIGSPLLTPWWAAANVVGGLVLVMWIIAPILYYKNVLFSAYLPILSSAVFDNTGKPYDVSKILTPDFLFDKVAYDNYSKVYLPITYVLSYGVQFAALSALITHTTCWHGRDIWRQSQQAFQERQEKNNLGYQAIPSSNGQNGHDEIHRVDSQTIKAGGEDVHNRLMRRYQDVPMMWYALTFVTMLAVGIFVVEYYPVHLPWYGLLMALGITTVLFIPVGIVMAITNQHSSLYLICQLICGVVFPGRPVANMVFVTYCYISSAQGIKFSSDLKLGHYMKIPPKLLFKVQMVATLVSSLVQIAVLNWMFINIPGICTTQAINGFNCPIARVHFNGSILWGVVGPQRFFGPGALYRPLVWAFLIGFIAPILVWLLGRNKKKSIFRKINLPVLFGSLSWIPPATGLNFSIWAVVCFVFNSFLRRRAPGWWGKYTMTMSAALDSGLAFSLLIVFFGFVYPGWTDSFSWWGTEVYKRGCDWQACAWFKLGPGERFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTL3</accession>
    <name>A0A1C1CTL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08774</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTL3"/>
    <dbReference type="STRING" id="86049.A0A1C1CTL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08774"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06272"/>
    <dbReference type="eggNOG" id="ENOG502SDN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5422283at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51938">
        <property type="entry name" value="SUZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="79"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ-C" evidence="3">
        <location>
            <begin position="241"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="324" mass="35312" checksum="565E4A660002C5D8" modified="2016-11-02" version="1">MSKIPDAWEDEWSAAADDSKLDPTASAEPKKVSSKVTKAQRRAQQAEFNRQLWAEAEGPKEANYFLESRNVVPLRSEYKTPPVLLSRKGPMIQSRSPRPPTVGMQDLSLSNDRTTAGQESSEDEDDLKAREPTLAERQAQAAKDREEKQKRYEERRKELFGSTTTSATSSFQPQGSHNRSGKSSPASLTPPGSRSATPNRARGARGGRRGGAVGDHAANSRNQPRGDFQQRELYDPSYGPKPDSLYSQRRERDSGSSTSNHAPGLSQTHVQQPIRAPKGPDGSGRGGFGFARTPMQLQAATHNGANLDTVDAEASIPNGTRVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTU2</accession>
    <name>A0A1C1CTU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenol 2-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTU2"/>
    <dbReference type="STRING" id="86049.A0A1C1CTU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08146"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06223"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="435"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="663" mass="74224" checksum="1E2C7F575FCD4FBC" modified="2016-11-02" version="1">MAPKVTYSDLVIIGAGPAGLMAAAWASRLGLNARILDDKVDRVQTGRADGLHVRTLEILDSFGLANAINEKAYQLREICSWVRAARLPLRAGYADCDKNPDPEDDSKIKRTERVRAKEEEHGRFCQLGIHQGFIEQNFIDFLRREGRLNVERNTATKSLQLDEALMSDHAAYPICLRIGRSTVTMNGDTADQGWRSPQEEIIKARYLVGADGGHSWTRDQVGIRLEGGKTKVHFGVVDIVPITDFPDIRISCSIHSTKTGSTMTFPREDRLVRFYVQLAETGSEGDDFDTSKVTPEMITEKASKILSPYKLSYKHCNWWSVYTVGQQCAPSFSKDGRVFLVGDAVHTHSPTMGAGMNVSMQDSYNLVWKLGQVIKGIAKPDILDTYNAERQSVAQTLIEMDREMCDFYEKGAGSDAHNYDEFYERFRTFLSGVGVEYGPNALVVPAREDGSRDSRSCTDLDKSRQTRGFSRRSLASKIPIGQRLPSFLVLNHSEANIVHVHSVLPADGRWRLLVLAGDISKASQMARLRILCERMDAPSSFLRTYTPEGDKVDSVIEVVTIHAAPRHKVELFSLPELLRPFDPKLGYDYWKCFANNNAGEEGDFDDAYAKWGVDKDEGCLIVIRPDQHVSLVCGLQEVEEVEQFFNTILVPQQRRKATAAACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTU5</accession>
    <name>A0A1C1CTU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylinositol phospholipase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTU5"/>
    <dbReference type="STRING" id="86049.A0A1C1CTU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08523"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06204"/>
    <dbReference type="eggNOG" id="ENOG502QUGH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="163"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="478" mass="53295" checksum="49EB4FCFE102E7EA" modified="2016-11-02" version="1">MAPPVTIRNISNNPLTLVLVEHFDPPPDEGFQMQNVTTSLANITNGLGLTNTTTRKAVPQIHADAKPFATREVSIKLPPFTIVPTDIKAIINKPNERLRLTFQTELGGKHQMYCPVPTEETASLVALVPNPKLRFTGIYLPNSSFVALFNTSHLDSWMKELPDRTPLGLLSIPGTHNSPTHHQAPPSVRCQAVSPKEQLKNGVRFFDIRVQVPEPYDPHSDKLVLVHAVFPISLTGNKYFRDLYNDIIQFLKDHPSETLILSLKREGTGKGTDEQLSRILKNNYTNPQQWFTEPRVPTLGEVRGRIVLLRRFTLEEPLKREWNGKGWGIDGHVWEDNTSGGSPGSLCPSGDICVQDFYQVMEKPSIEKKITYAQEHLERSGCCALRGQNVGSKKIPLYVNFLSASNFWNVGCWPEKVAAEVNPAIVAHLCQRHMIGEHGKVKDGDWSTGIVVTDWVGLGGDWDLVRCIVGMNAKLIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU24</accession>
    <name>A0A1C1CU24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU24"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11391"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06127"/>
    <dbReference type="OrthoDB" id="4136758at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="70" mass="7589" checksum="A168310FB79B2C32" modified="2016-11-02" version="1">MSTSHGSTTSTRDGPFELKTVDAASSSDDLRLSDKDTPQVLLEYTAYLGRCIAGVDDKPTITSVPKTRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUJ5</accession>
    <name>A0A1C1CUJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUJ5"/>
    <dbReference type="STRING" id="86049.A0A1C1CUJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08626"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05984"/>
    <dbReference type="OrthoDB" id="4161517at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="426" mass="47051" checksum="FBF6CAC95B583430" modified="2016-11-02" version="1">MFFLSSPTPAPASEPEALPNPFSSPVTTRQYVPPRSTCTDSHTRGNSYYSTKAYNRGYYTPHAPSPLRLESSPLRTARNANLMSSPTRSGGSKAKSAGGGGGGLMLSSSPPRCAVDGVDENWITDEVDGDGGSLGQSGFDNPAHSTPVGKLNVSMGESLFNAPTHSTPVGKLNFSMGERGSSSFVTSPPDSAPHPQATRAAVPAAAFSSPVGSSFSFAAPQPSSASQWELRSRESSPSTLLATQTARNREERKSRFLDRIRRRRDDQRSERVGDQVLRMDFVKERRGWEEQMARRAAFEAGVAIEEAEEEVVEEADMQNDTEFGAQEMSPTEEYDDLVRDYENGYEYEYERERGFDRQGEMMPEDEFEFPVDEADDEEYERLFREMEILSQQSVSQVRDIMAQEQQHPSQQGMEHRSGGGDAMDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVB2</accession>
    <name>A0A1C1CVB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_09971</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09971"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03831"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4160219at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="56"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="573" mass="61616" checksum="ACD78AF9F1BB6AF1" modified="2016-11-02" version="1">MTPNGARSERTPLLSSSPNTFAVLNRHTTESRDVSPLSRTDKGQDDKLSTTRGALICLSVWVLIFILTNNVSLITTIQSPIASDLEVSNAVSWFTSAYLIAITSITPVAGRLCAIFTPRIYLLVSIIVQTCGLFVTSQAKSLPWFLAGRVITGIGSASVTPVAFLLVTELTSQRRRGLFFGCINTGYTAGVACGAIIAGALEPLVGWRAIFWLQIPFALVAVTVAFFSIPKPKQASASTAPEALAKKLSQIDYFGVFSIVAAVVLLLYSLSSPRIQMTPILLSVASFILFIFVESSWATHPIVPVSVLRSRGNILTGLATVGVMTARWGVLFYAPTYVLTLRGWPQSHAGLTLIPTNLGFGMGGLLAGWLHIRRAGSFYVSCIATFGLFALSMFAVSWISTPSSNIHLYLTVLFVNGFIVGSLLNYSLAHVLHLTTPSTHIIVIPLNAMFRSLSGSFGSSVSGGLFLRTLQKALTQGFQDRGIFEGKERLIRQLVGTPIVVQQLTGVDKEVALFGYEQALKTIYMAGGVLAIFMLLVQAGTGWTAPEVVKDEEDAVEGPEGIERTISREPVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVG4</accession>
    <name>A0A1C1CVG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apc15p protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVG4"/>
    <dbReference type="STRING" id="86049.A0A1C1CVG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09726"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03909"/>
    <dbReference type="OrthoDB" id="5320532at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008402">
        <property type="entry name" value="APC_su15/mnd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05841">
        <property type="entry name" value="Apc15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="707" mass="75544" checksum="6C699EDE55D75898" modified="2016-11-02" version="1">MMFLSTSLPLLPPPPSSLFPPITAPSSDAPTSTPAAHHHHHHRRQKHNAAYNARNSTLLALSTDERTVSQRKMAIAMYGYSWLKPAGCAKTMLGRREEEVEREEVERQLREVELQERLALETEEQERMARAQELGEGEEGRDLDEDIPDADDPDPDADYESEEEEEEEEEEDGAVEEGEDEDGMEMGMAADLDDEIPDADDQEAEDDGEPLSPVGADGGWVYDTRREPDTDDEDQLPQPLPPPRHRDRGHARHTTVAGVQVPLSGSEYDYDERDAEALANAMLDGDDMYEADVHGPGRSTLSGDRDLDDDVPDADDDQAWEHTDTELEESEMDISILPQAAQPGHGRLSGGGQESPQLHPQFLPRSPARAAAPRSSGPWITGPSPLPSPDHRPHQAQPQIMPRQRGAQAITPEMAITSNARFTPAQRSVSTRAARIVSGNRQRPYRPDLARPTTRHQLQQTHTPELLDTPPLAAEAGVDIDVDLDPDVDDEEVDTDIEGEDAAAVDINTPDLFAAPEHARGRAPAQAGTRDQGRQLRAPAIGVPRARGQGGRAGATAAGNTSPSRAATARNWLDGAAATLGVGGSRDGSASASASTSTSVGARRTLFQRATRRRNAGAGTDADVAAEPQTGAPATSSGGLFSSPNVASNGGEVGSGGAGGGGAGGGEWDTPESASTGAPPAQTQDQGRRDGRRRSGRFLAGRRRAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVR1</accession>
    <name>A0A1C1CVR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RFC3</name>
        <name evidence="9" type="ORF">CLCR_10277</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVR1"/>
    <dbReference type="STRING" id="86049.A0A1C1CVR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10277"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04010"/>
    <dbReference type="eggNOG" id="KOG0990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="78"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT52622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="408" mass="44821" checksum="101F3D60343D0D8A" modified="2016-11-02" version="1">MSDYEDDMDVDVAPVKNKEIQFSADGNAGKQKRIVADLPVEAEDNLPWVEKYRPNTLDDVSGHQDILATINRFVEHNRLPHLLLYGPPGTGKTSTILALARQIYGARNMRQMVLELNASDDRGIDVVREQIKTFASTKQIFSASTQQNAGSPKLGLGAFKLIILDEADAMTSAAQMALRRIMEKYTANTRFCIIANYTHKLSPALLSRCTRFRFSPLKEADIRRLVDLVISQEHVNITADAVDSLVKLSKGDMRRALNVLQACHAGSRPLPMRGQPPVKDSDIKYELITNDTVYNCIAAPHPEDIRLIMTTMLSTPDLTECLRTITALKSSRGLALADILTALAEELQTLEVSAPTRVTWLQGLAEIEFRLAGGGSEGVQTGGMIGVVRTGCELMGEKGIAERMSVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW01</accession>
    <name>A0A1C1CW01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW01"/>
    <dbReference type="STRING" id="86049.A0A1C1CW01"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10180"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04090"/>
    <dbReference type="OrthoDB" id="4132249at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="469" mass="52542" checksum="1AEFAAE81B2781D2" modified="2016-11-02" version="1">MVHSTSDWCLDPVAEAPKDHQRLDGFSLRSWVLTPVLDTEQPATIESETLEPQILPDRLDNAATTAPSPYQLPISPTVAIQSPFEPKPDTEIWRSVQHFFETMHVIFPVLSYTDLLSRFVLEPQWSAVPDFRTLLFAVRMVTAAGEHRMTSNNAENLKKFIEQVERSRLCYDFAECPTLDEVIISLFLFTSYNVLEKHNRAFLYLDEALSLMETVQPDGAEEDARRMHIEQVLYNTEAASFAIYAGKGRRRRAKKPMVNLEHSSIKPLRIETGEQSEQVALHLLDRLTEIHVAEDTEALRIISTASETDMKTLFGAAFGMHRYCRIQAADVAVSRQWQLSSKLVSGFRQRPGVEELRQSTIESLGNAALAWICLLKEGESRIVGLGKLSGLAKNIVALSGGRCPSYPVAGLVSAIIREDRERQFAPELADVVLPMVSTIPSTLYPVIDGSMEGVPENESTLHSYLCTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW75</accession>
    <name>A0A1C1CW75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Periodic tryptophan protein 2 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_09573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW75"/>
    <dbReference type="STRING" id="86049.A0A1C1CW75"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09573"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04065"/>
    <dbReference type="eggNOG" id="KOG0291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000470">
        <property type="entry name" value="Periodic tryptophan protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="335"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="377"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="463"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="745"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="863"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT52686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="888" mass="98223" checksum="07B157ACA765355E" modified="2016-11-02" version="1">MKTEFKFSNLLGTVYGRGNLVFTPDGNSLLSPVGNRVTVFNLTKNTSYTLPFSHRQNITHLDLTPDGNLLLTIDESGRAILSIFPRRLAIYHFSFKSPVASLAFSPDGRHFVVGMGRKIQAWRTPTTPGQGTDGDLDFAPFILHREYGGHFDEVRHLSWSGDSRFFLSASKDLTARIWSLDPEEGFEPTVLSGHRQQVRNVWFSADQESIYTVSEDGALFRWGYQSSQPENDEDSTDPSDERWRIVQREYFMQNAKLRCACYHPSTNLLTVCFDNGLFSLYEIPSFSNIHSLSMASSRISAVAVNQTGEWLAFGSSQTGQLLVWEHASESNILKQSSHLDAMTTLTYSPDSTRIITGADDGLIKIWDVSSGFHIATFTEHTSAVTASAYSRRGSILFTSSLDGSVRAWDMLRYRNFRTFTAPQRLSFSCLAIDSSAEVVCAASHDSFDVHLWSVQTGALLDQLAGHEGPISTLAFTPDGRYLISGSWDHTIRIWSVFDRSQTSESLQLMSDLLCIAIRPDSAQIAASTLDGSITFWNLNTSIQEAGVDGRRDVSGGRTLTSRRTAASTPGTKSFNSMTYSADGSCLLAAGNSKYICLYSVSTLTLVKKFTVSVNMSLDGTQEFLNSAAIMSNGLPNGIIDTEGEASDLEDRIDRSLPGVKRGRDATSRTLRPEVRVTDIEFAPTGRSFCAASTEGLLIYSLDDVGTDDFDPFDLDIEVTPQNIRALLAQAEPETLKALVMAFRLNDKPLLRQTYESVPFETIPLVVRELPRVYLGRLLMLVAQQMENSPHLEFALRWLGEILSVHGRYVKEKQADFAAELRAVLRGVDGIGRTVRSLSERNAFEIEFMCHGPDGQGDVGPHWLGEGDQPKTNGITNGDGGEQEWIGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWS9</accession>
    <name>A0A1C1CWS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Quinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">qutB</name>
        <name evidence="3" type="ORF">CLCR_10597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWS9"/>
    <dbReference type="STRING" id="86049.A0A1C1CWS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10597"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04237"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="204377at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF26">
        <property type="entry name" value="AROM POLYPEPTIDE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="1">
        <location>
            <begin position="116"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="305" mass="33282" checksum="B4846FF45E6821DE" modified="2016-11-02" version="1">MPRSRVYMAGAPGGGTIAAPAHDFIAQCLGKSWTMSFLEAKSIDEVVDTFRAPEFAGGIVTMPWKKNIIPHLDYVDGIALTLGACNHVSVNDDGTLHGTNTDWIGVRDALLEAQTSSSIVAGRRGLIIGAGGAGRAAVYALTSLGCKDIYVVNRDAGEVDGLAQDVQNYETASRPNVTHIQTVHQAQGLFPPHYIVGTVPDFEPSIASEIEAQSVYVEFLSKERPDQSVMLDMCYHPLQTRNLRLAQQYGWPTVDGVQVVGHQLKAQWKPWTGRELEEEQEKAAWEILRRCALSDPTVTPQEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX86</accession>
    <name>A0A1C1CX86_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_10600</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX86"/>
    <dbReference type="STRING" id="86049.A0A1C1CX86"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10600"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04398"/>
    <dbReference type="eggNOG" id="ENOG502S08R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5586015at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="174"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT53061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="243" mass="25341" checksum="97A29358C96C5A6A" modified="2016-11-02" version="1">MAQPRPTTLLPSRTRSRSPTSRPTTPLRASSRSSFRASTTLPNDTIPTGLDHLEPQFAELSDSMADLEANLMHLQLMHESLSRFGESFASFLYGLNMNAFVVDFPEAPITESIKRWQRRQQGLDANSSTINVTMPNSNSNSNSSTVGGLSQSEGNAGDATFVTNADASFASLKATPRRKTVAPPVTPGTTSTVQQSRLPGARRGGGGGAGAGTGAVGRGGRGDGAARGARGSGLPRGRGRGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX90</accession>
    <name>A0A1C1CX90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX90"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11113"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="75" mass="8947" checksum="B3537CCDC2EBDFFD" modified="2016-11-02" version="1">MREKAKTRKRRRGSEDEEAKTRKRRRGSEDEEAKTRKRRRGSEDEEAKTRKDSSELILSFTPVLLTQLHSNYRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX93</accession>
    <name>A0A1C1CX93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_10550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX93"/>
    <dbReference type="STRING" id="86049.A0A1C1CX93"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10550"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00080"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="167718at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12400">
        <property type="entry name" value="RRM_Nop6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000376">
        <property type="entry name" value="Putative RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034228">
        <property type="entry name" value="Nop6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF51">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="145"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="321" mass="35803" checksum="E0CC4A9F15A945D6" modified="2016-11-02" version="1">MSKKRKHEQIQDRDDLQITKPQPDKTSQKEVSAVPAKSKGQLKQEKSERRAKKQKKSKEEAPEQDASTDHAANVSSSLAPVAAEGASSQEPDGEMKRSKKDKKKAKKEKDDGDKKKAKKESDDGDEHKAKKEKDDGDKKSAPARFICFVGNLPYDATLDQINAHFSKIAPTSVRHATEKASGKSKGYAFLEFDHYDKMKTCLKLYHHSIFDPEAKGEGKDAADAQQDDKEQTKTSGKQKGRRINVELTAGGGGKSKARKARINSKNQKLEEERGRRRLKEKAEREQGSRKHKAPPETGANTVEVKDTRGDIHPSRLSRVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXJ5</accession>
    <name>A0A1C1CXJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G1/S regulator NimO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_09776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXJ5"/>
    <dbReference type="STRING" id="86049.A0A1C1CXJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09776"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00178"/>
    <dbReference type="eggNOG" id="KOG4139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="590"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="542"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT53215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="639" mass="71569" checksum="A8561606462E8773" modified="2016-11-02" version="1">MATSSRRLPLASISNAANSPHRPLTNSGTKRPRALANLPQQENEPPQKRLASEKGPRVVLHPVTPQKQPPPSMPEGRVFERGQGEDRSTAFQRKLVAARDRDRTAGLRVTKNVDAPSKEDSMKQWQRQYRKLFPTFRFYFDGFSDEAKSRFLRQITALGGREEKFFSRDVSHIVTTRPIPGELGKNGSAADHSAQHSPTEDQPQTINPSLLEKHPRGQAAASVTRNGTNQLDILVRGKEMGIKIYSVDKLQRLISSMLAGTEGHNHNTRGASQTTRQQREDLGEVLRNEKLGVASERELPLTSLVPFKGPFVYVHDMDEKYRPTMVREYPKPATRAEGEWPQFRSAGIGKCPFVVDPNFEQDQRRAQKRALQQEQQRQLQQRREQQMPRTRSHVSVSTAVPNALRRVSPRKPLASVQVPARAVPDVVKDEKEPTSYSSTVDRQPSFPPMPRRAEVEFVRPPKLQLGREPAASGIQRSNLTSAIQSQMISSTAATGVKAGTSKEVHQQLKRQVLERTHTGSLSVGSIPSSHRMTDLAGALKTARAPAPQRAAKSKAQEKLGGIQEEADPHEDDIAAERAAHASRKKKSVRKDPKPGYCENCRDKYDDFDEHVVSRKHRKFAMTQSNWTELDALLAKLQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXQ2</accession>
    <name>A0A1C1CXQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RanGTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09691"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00216"/>
    <dbReference type="eggNOG" id="ENOG502R7I3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="512915at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008812">
        <property type="entry name" value="Ran_GTP-bd-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010:SF2">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05508">
        <property type="entry name" value="Ran-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="467"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="741" mass="81579" checksum="C86395E924847CC3" modified="2016-11-02" version="1">MDIFLGKVTQQAMNYAIRSGVTITASYAIRQSSKLLSSTPKSNIRDELYRLQQKLQHKIRIVSPAIDLIELIAARGNTSLESAVALVKELRLEIQSLGQRLAKAAEASEQVARKSSKWSSQARAQNEAELSLIIKDIRALLDRIEDAVPLINLAITTSGASLSTQLPQTVSPSRLLQASTFLTAGDTQYSMSPNQAVQIGPTFTLTVYMLFAGHNRPQDEEELRETTWKEVIHKARVKLRRVPLDLVTGAGSGSDTIPSADITSPVKLASTDTNSDPVTNGSSIRALTRADEYAYQLLIVEDFDDDRVHDFSDVPLHSQPGPFDDVALAGIRETIPVHEISKIFYADTSKVLNIGSDAESNHPVLLLKRDLNAVPPRRMAERDDATGAWRDGEEAQGGFIAPVQEQPQPRVEDDTRQAHANARSHDDHDPWRLPPSLDPEWIAFEVYAESEPSDSESEGEGEDSMLEDPTTAADEAAASQLTSHLSSLHLNTPTLSPHPTTSHGQLRSSAPPWANKIVTSLSLLELLLRLTSLQQFQQQSHLSITDELLTFFLEESASTGAGGDERYRQHMRMEARRRVGWDPYNESPIKRRGEDYQYQYGYSADGNGDDRDDEYDYRSGYRDGHHDESPGSMNGGGRRATLSWSPTSERTRDPGESGRRDRDRNRNRDVGDRRVTPGPMSPSPRSSPLPSLATPAGKAGRAAWLRRDGDASRKGSPLRPATALTDEGIGTSPVSGTDEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXT2</accession>
    <name>A0A1C1CXT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10244"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00252"/>
    <dbReference type="OrthoDB" id="20734at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="445" mass="48092" checksum="1B5AF7289F6A2972" modified="2016-11-02" version="1">MLLARHLWRSRHGNAFQNARTGASASVPVPVKKKATPTHLVSRRWFFASRVARSVDANDCPSRTSLHLHHQSAAPAPTASTGTAATAEATAAEVDEESRARTPASDKPPTRRTQLDTAARPSAHSSLDSFQAYARRTGLSPTSTVYAGTTYEYVTQATLRDYGFELYRVGGRGDRGVDLIGVWRVPGSSSSEKWDGREKKNDTSPQLGAESSPTEPGLEPELVPLPQRYETPALALKVLVQCKRLVGKHAKIGPHLIRELDGTVRAARITPLFEAVLAQDVMNTTRSTTHAQEREEADEGPDVDVDVDVDADVEVDTPIVTDNQHRHHSPMAGTLGAAGPAIGVLVSTKPATKGVVDSMRRSTRGLVWVMMEEVIASPETELEGSPSSSEAPSPTTNLSGRVKQILWNQAARDLGLEGVDVVKRYDGKGREEVVLMRGGRVWGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYF0</accession>
    <name>A0A1C1CYF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">acylphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">acyP</name>
        <name evidence="4" type="ORF">CLCR_11016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYF0"/>
    <dbReference type="STRING" id="86049.A0A1C1CYF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11016"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00488"/>
    <dbReference type="eggNOG" id="ENOG502S7SZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7961613at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268:SF4">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="90" mass="9578" checksum="9E867E00A24E69F4" modified="2016-11-02" version="1">MSKRIAFTVHGKVQGVCFRDFAQSKASSYGVTGFVSNTSDGKVAGEAQGDDEALKKLKADLNEGPKAAQVVKLEVKDIEVKDGEKSFNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYV2</accession>
    <name>A0A1C1CYV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclopentanone 1,2-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cpnB</name>
        <name evidence="8" type="ORF">CLCR_09904</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYV2"/>
    <dbReference type="STRING" id="86049.A0A1C1CYV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09904"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00661"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="543" mass="62714" checksum="A7C3D26CAB271C0E" modified="2016-11-02" version="1">MGSHQIEEVDVLLVGAGFASFTLLNRLRKLDYKVRIFEKGGAAGGIWYWNCYPGARVDTDSPIYQLFDKELWEDFTFKDRYPGWQELREYFNYVEKKWNIRDYTSFNKHVDSAVFDEIRHQWLVECADGTEIYARWFIPCIGFASKRYTPPFQGLGNFKGDIYHSAVWPQHGVNLKGKRVAEVGTGASGIQIIQEIGPVVKELTVYLRTPNLCLPMNQRQLDPKEEEEKKKNGWYEEQMEKTRHTFAGFTYDFMEKNTFDDTPEEREKTFHKLMVEDGGFKFWLATYKDMLFDLKANKEAYDFWRKQVLKRLTDPEKQRLLAPEVPPHPWGTKRPSLEQRFYEVVDQPNVKLIDVNENPIEEVTATGIRTKQGLVEVDVIILATGFDSVTGSLAQLNIRGTKGGTVADHWKDGTKTSMGIALPEFPNMFFLYGPQAPTAFSSGPSCTQFQAEWVEKVFKLIKEKDITRLESTKESEDEWGKRLAEKWDASLFPLAKSWYQGANIPGRKVEPLNWSGGMVEYVNTLNRSLENDFQGWKYSTAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ41</accession>
    <name>A0A1C1CZ41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_09893</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ41"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09893"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00735"/>
    <dbReference type="eggNOG" id="ENOG502S0C8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT53807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="590" mass="65966" checksum="5E74F1FD73EBAF08" modified="2016-11-02" version="1">MVYKGPSRGCYMCRKRRVKCDEKRPQCGNCVKRQQRCPGYRDFFDAVHKDETFVVSQKSGSKRQKRTCARAQEDLDGSLESCLFEECIIGDSTDDSVDSSVFRIFDNARASPALFAQPSRNVAIESLCYFFTNYVNTPRDPSTNIFIEHILPMYLNTPPNSALSEAIHGVAINVTSLWMARHVDSYLAREAYGKAVTRLKALLEDPVQCKTDETLATVFMLDFYDSLNQRFVKFRDTGTHQQGAVALLKYRGKDNFKTPLSQRLFNAMRSRHINYSLQAGKDIQLDPALLADATAVLPSAKLDLLNVELATLHKLAQGGPEALDLSMTEFYKLVLSKALVLEKKFQAWTDSLPISWRPVSISAADLHPSIREAGLYENMCDVYSSLAVSHVNNAARSSHVGALRLIALCLGGLEDLGVAVDPDIEIHVNDRIQSVVDKFCASIPFHLGNRTGITFPHERREYPHIPAELRRLANYVDPFGNEVEMTMEDHARAAAAIGGWFIMTPLAGFLTAPALRSPKAKPGPLMRKLRAGQLAWIRGQMSRIQHIYSFASDGSRQYPDCTRVLKTPGSEQCKNVHSTMPSLNHSLWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ66</accession>
    <name>A0A1C1CZ66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinate-semialdehyde dehydrogenase [NADP(+)]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">UGA2</name>
        <name evidence="5" type="ORF">CLCR_10045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ66"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ66"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10045"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00733"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000023">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF7">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="512" mass="55516" checksum="5DB1AC668BFD95B2" modified="2016-11-02" version="1">MGSSSNLPFELKDPDLLKQESYVHGEWVQAKSGKRFDIIDPGSDKVWASCPDNAVEDVDAAIQSSYNAFQDYKILNPRKRAQLLYKWHELITNAKEDLAKILTYETGKPIAESIGELDYSLGFTWWFAGEAERIHGSVFTPSAPNRRTFVVKQPIGVAVALVPWNFPIAMILRKAGAAFAAGCTMVVKPSPETPLTCLSLAHLATKAGFAPGVFNVLTTSLDNTPSLSEAMCLHPLVKKVTFTGSTRVGKIVASLCAKNLKKCTLELGGNCPFIIFDDADLEQALAQFMALKWRHAGQACISANRVYVQSGVYDKFTQMLVEKTKTLKVGHGAEKGTTMGPVTTPRGLAKAEEQAADAIKHGAKLQLGTGKAYKNAKAEEGAGSGKGLSGYFMDPTILTEMNDQMLIAKEETFAPVTGLFKFEKEEEAVKWANDTSMGLASYAFTKNVDRIWRMLENLEAGMIGLNTGNSSAAESPFGGIKESGYGKESGKDVAVNEYLISKTGTLTIDGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ94</accession>
    <name>A0A1C1CZ94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Norsolorinic acid ketoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ94"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10681"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00734"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="253" mass="27041" checksum="946FE2F06740EDF5" modified="2016-11-02" version="1">MAFTTTVLVTGSKSGIGKGLLSAYASRPNTLAIAAIRDGPDSVAARVLTSLPVGPGSKIVVAKYDASSRTAAVELVNFLQSSHDVSSLDIVVANAGILKHFGPAKEASPETISEHFEINSLAPILLYQATQRLLDASKQTPKFFFMSSNIGSNGLQDHYPLPMLAYGLSKTALNWAASRIHREEDRIVIVAMQPGWVQTAMGNRAAAHAGMSPEDVPVTLEASVNGLVTVFDKADKATYSGKFWDQNDVQQPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZY0</accession>
    <name>A0A1C1CZY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MmgE/PrpD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_10102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZY0"/>
    <dbReference type="STRING" id="86049.A0A1C1CZY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10102"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00843"/>
    <dbReference type="eggNOG" id="ENOG502QVEB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267976at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="3">
        <location>
            <begin position="31"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="4">
        <location>
            <begin position="318"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="505" mass="53135" checksum="9DB011EA439094FB" modified="2016-11-02" version="1">MGSIDKTINGSPNTSHKPGHDIPIPPVTEILASFVADAPSHIAEYLTPQVRSRLKEYILDYIGVTLAATQSCDSTPAFLAAVKALGGHSSSSTGPDACTVLGVGKSYTPQYAGLLNAALGHSLDFDDTYAKGTLHAGVTAIAAAFAQAESLGTSSSPPRPPPPPSMDLVLVAIATGYEITCRLGAVLGPEAYARGFHNTSTAGIFGAVATLAVLKRLSPAVVSNAFGLAGSKAAGSMQYLANGSWNKRLHPGFAVHDAFVCVALAEAGVLGAAHILEGTMGFLHAYTSKPTVAAADLAWLTHDLGVRWEFLATSLKPFPACRMTHGFIEHAATLGVAAGRVRSAADVRRITLSLSPSNVLVVGVRSPNKLHPGNMVDAQFSAYFTTANSFLYGADDARGVQCYRPDRLADRDIWALSEKIVCVGDERITQFGSRIKVEYADGQVSEVDIPVPLGEVGRPFGRELVERKFRGLVEPVVGRERASAIVKAVDELERSTVGEVLGMLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D018</accession>
    <name>A0A1C1D018_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine Rich Repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_00160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D018"/>
    <dbReference type="STRING" id="86049.A0A1C1D018"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00160"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02550"/>
    <dbReference type="eggNOG" id="KOG1259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT54144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="771" mass="84787" checksum="8D5EC81C17E72C1B" modified="2016-11-02" version="1">MDRLQTEDGHHFIRSLAQFIRQHEKALANSLQMSVHRRQSSGITVSTNNTTVTSGIASSNATNSTSALAAAFSLAGLSFRSHAAKAALLTLTPHHLFYLLSRMDELDITVGPMNVRLENLSTDPTPSNYVSFLQAHKPAKGRSDKDSVHSVSSMRSVMSGMSSFWSSIGLGGNNSKSEKAKALTQADLTYLYSAFTKLPSLRLTSDHRARLIRGYEEFPFDTAVPLFAFKNLQQLDIVDLDFRQFYGWDRLAEQLTLLTVKRANVSDPTELLTNIVLDDAEKRRRRSTKGGRGSPTMSASWTVPSTPRAEYAQSHSDPGSPNPGSLENEEEAIGPGNKTRPLSGSVSPKRPGASRPASSYRQMRTYSTTVKRTGSGSSYSSEYSVQAHRSESSPNILSLNILPSSKWQRLKYLSLADNSMTTISAKSLVPIASTLRSLNLSSNLFTEIPDGLASLTRLVSLDLSNCMIGSLQSLSRSPLPAVLTINLRGNRLNSLAGVERLLSLEQLNIQDNKLADPMEMARLTGIPNLKRVWVKRNPFTQTHTDYRITTFNLFRSTPGYVDDIVIDKSGPGYSERKQLVDRVPEVERQIVQPSIRIAEQPVIVQLANSAQPSSSEVAEVLTNGSRRKRAPRRRIVDLAHDDTFARVPDEDLAATLDPVADVVTQDAARLSVDPAGPRSTTMKTLAEDVYDGSTDALSVVSSEPTKHQEDYRAKVEALRQEFGSNWLSALGEQNWHNSHQFEVLQGQNMGHDALHRSGHHQIIVSGGRTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D046</accession>
    <name>A0A1C1D046_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D046"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00206"/>
    <dbReference type="OrthoDB" id="10403239at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="167" mass="18079" checksum="897D2AD070FE0F9A" modified="2016-11-02" version="1">MVESVNAVTARSGDHTAESDHDQMDTERGVEDDGTDGWSHRCSKNDSDEQSVDGNTPQAEHGENDIGSAGAHHEESHFHPRAGDEELVTQCFPARMATPPVIGVPHNASTQASLSFGPPENESTDTNEPSEPLETESNSTEEPQPPSVRGRNLKRKASKELLGRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0M3</accession>
    <name>A0A1C1D0M3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps11a</name>
        <name evidence="6" type="ORF">CLCR_00953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0M3"/>
    <dbReference type="STRING" id="86049.A0A1C1D0M3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00953"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01666"/>
    <dbReference type="eggNOG" id="KOG1728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT54399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="162" mass="18510" checksum="0F8EDFEB35619E7D" modified="2016-11-02" version="1">MATELTVQSERAYQKQPHIFLNSKSKGAKSRRVGKGGRRWYKDVGLGFRTPKTAIEGSYIDKKCPFTGMVSIRGRILTGTVVSTKMHRTLIIRREYLHFVPKYARYEKRHKNLAAHVSPAFRVEEGDTVTVGQCRPLSKTVRFNVLRVLPRTGKAVKAFQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D175</accession>
    <name>A0A1C1D175_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D175"/>
    <dbReference type="STRING" id="86049.A0A1C1D175"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00762"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01737"/>
    <dbReference type="eggNOG" id="ENOG502S215">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1883964at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1311" mass="141525" checksum="A57586964A6AA73F" modified="2016-11-02" version="1">MNPYNQPPYGYAQQTPGPPQPPWQAPPRRQGWGDPRIPGQGLQSPISPAYPNIPPSNAFGPPLPPPPPLPLPQSQYPPQPQWDTSHWGVKYNQGLAASGQGPEQETKPALPPRPTSATGRLSPQPHQHDHSQPYSGWNDPYHTSNAVPPPPPPRPPEYQVHIQAAHPGQTSTPHQEYSHRPASHHYDPVPLQQNSWNTQPPQTAGPTYYPTAPPPQHLSGTVDGPLVSPIESTSGFWGAPHGQQSTAPAQNNYNAPPQQPQDKPASTQVPGFGGPSDWEHYDPNAPPPDQTPTSPPANLLYQTQGPISPPQTHASPAPVQQTPKPEPARPTYPVEIGAPSPVTPRKDTQNPPPVASYGPTPSQSTADGRPSSAGQRPSDMPARSDSLESAGNIDSVIQAWNTPLKPHPVPDSTPRPESRASAPAVPNPASGLSSTNVKSVDPYADLEPEFKASLKRYAVMLRREAAAKTDEEKFDVFQGFVTKELRLRSLLYGVELRKEAAKEVEKAASLADIQAVLPKSALTPATTKPDAVDQLNDPITKTEDSVPAPALPEPSPTQPPASIPRAPTQPTVIPQERPKLDTPKLASPAPALAPQAVRTPPVEDRPQSKDDGYVMVAAPGREEAYSPGGRPVMTKVKAGDDDEAYSPGGRPITSRAATTSPARPAVGTMVQEHPRQTAQNALSPSNDAPMVIEDYITPQPTSPSVNAPMIVAAEPPVAQASPRPNQDSQKPVAPIKFEPPRPVYTPFRYSAGVQEEKTKTSSLRPADQAYSSLRHSQAGSGRLLAQDAALLAPMRPSSSSGRKEHEEAFIGLIRKQSMAVRQITPGSAPPPLPRSITPGGINNKGTAAAKPEPPPFMRVGTPAAPAFKPQQPADVVKDAVAALRSLLPSLDDLPTPIDSSGSNPKLRIVRSKIDSVQDQFSFIHEAVVEWDRTNRLVRKEQEAERQQRQGESEAHIDALFNDNEIGYADIGALEAEFKLSEAEKRYHEDQAELESFTSQVFVVVTERLQKEIAELKSAYTMAIDVLDLESVAVSNCFKAPNGDKKPIRMTEIMSCVLTLFNKIEIRHQKLAEAHLERERRRKHLELTILYTNGDVQGVKQLEKEFVVAEKMAVLHEARGKDDRANKLMDSFDRATVRGLGDNQVFTDEVLAKLQELKKAVDALLSSSDERDILYGANGATDTLSLAHSTLDSITNDSRRLLGLSNEGDILLNEADYNVSVAEARVANADSSVYTKLQEEKAKEDSKLIEEMNARTASVTKGPEEAIRLVRDIQATVVGGGEGHEERIKRALEAAKARNASTGEGGGGGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2E1</accession>
    <name>A0A1C1D2E1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2E1"/>
    <dbReference type="STRING" id="86049.A0A1C1D2E1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02705"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05036"/>
    <dbReference type="eggNOG" id="KOG1822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="3">
        <location>
            <begin position="1849"/>
            <end position="2014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT54946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="2032" mass="220374" checksum="91E78FA4CBB2748B" modified="2016-11-02" version="1">MATPSPAPQPQSAPAVNGAADLELDVTKLHSLDTAQQDLYLLTFVSDLQRHVEQLSAEALPSHQASIKKEVIKIVGLGAPVPSRVIRNALGRILADVFARGSRSLLYETINDLLAILNTGKADKELSSKHSAIVCIGAVFRAAGDSAISLSGLTAASLIKLLKASSVGVRGCVFRALVGVVLGVKGSLDEHVSRDILKAARNAATSDKSTFVQRCACSCLRSLVSETSYFNNSNDFESLKSTIWKVLDSSGSSVRHAAAAAMAASLQQAYSATGHAEVPVLRKPKKSKKPGDDLEEEAEIERPGSPAPGQVKPSVRLTLTLTEVLRVLSQHYCRASTTNRARAGIAMCYRFLLRLLPRKPLEEEYASIATHMYADLLNHPTISANRHRLLLTRKLVQWMLADVTVLLTENAQINAARHLINDVLKNYPQVMPERREPSKRILAGALTTLNDLLLQLGPAANVLQDSCREALFQVVQHPSHTVQSHAAQCFKAFILACPNQLTRTIDHAMAQLQKEFQPSEGKQPHRRSLGFATAIAIAVSCARQKPLYGSVQTYFAIFTFATDLLKSSAAAELRLSAMQVQVAWTLIGGVVSLGPSFVKVHLNQLMLMWRNALPPPLTHENASRRGHLELSFLSHVRECALSALLMFLSSCSGLITFDGSKRISTMLHNTILFLNSLPPARESEDLSHRLVPALQLQDFAILLRRRVLQCFASLVSLRHLEQTEVVSQSDLIGLTMTTFTDPERPVLKSLEASLANTASTFEGLWTTEDNWSFGVSSLVDHFDTYLPFESHSPPGSDMYTDQDVSVPDILLRCPAIPAIEHDAALIARQDTSSSDAELSSPATSCVNLSIKLFAISLPLQSGRIQESTIEQLITTVSQQLQREPGRKAAMQVNAALALLCALAVANNETPYTSGKMNVGAIGQAIIDLLGKYMCSSDPALRHIAARAIGRICNLAGTQFTNKEVKFLIDMIVANRDPSVRAGCALALGHIHSEVGAMAASLHIKSIVGVLLSLCSDTHTIVHFWALKGLVLVAESAGLAFSTYATSTLGLLAQLYSNDSHNEEAASLTTSNFELELFTPLAIAQCVDSVVNVLGPDLQDVSKARNLILVLVGYLQKEASAQLRSESYQCLRHLCMYAPAHLQFAKYVLDLQANLLSDEELLQSAAVKGLDELMKRNASEVARVATSKLGDDLWARLDDNPGSGSLQAMLQNWMQQTILLDTADWVDKCQSILSRTRAKAPLTSRVQTATVKTAMPDLADEDVAGLTAAAGGQGDAADAAPEGQEFLRWQTRDFAMRLLSEAMDIIHAGMSPDRVIHAEEVLQSKVADVVRVAFSASTANVVELRIWGLRIIDQILKLFGKTPDPDFLEASLLEQYQAQISSALTPAFAADSSPELAAEAIGVCATFVATGIVTNAERMGRIFKVLALGVDNLTRPTPEAAIGDLNNLSPNAQAMLKMAILSGWAQLQLASADQPYLEEILQPFIPKLAPLWLTSLQEFASLRFEPEISDTLGGEVAGGNLDERYASFNREVRLKFYQTSWLSVVDAIAVLVEKDSESVFDALDNKRVSAADGQANGTATPGKDMSFREEPVAFFFILFGLAFEALVTQAREDPSQVLSILQALRKILTPEVCGNAIYEDAVFNETTDTLDRLALTSTRETQSELVEIARNLSLDHIAAKNQDRDDKLSDDIEQLFELTRIIILVLTGLIPTLEDPPGVASRRLGDDGIALVQLCFQALVDVASVFPAIIRADLHACIMHSYCTILATGICQDAVLPRIMPIFKAFLQDVIQSAPGDVASRLVRGCLRRMLSILAVAQRRENEHAITCAKNTLLSMTILLTTASSVLPANDDSVAQSLSELLDCLQDVGLAKIAAGCMRSLLVTHPKSACDEVVGRALWTRLVQFVSDHEAEDPESVKAALTQALVAAVVTIKDSGRPAAMSILVPVLLLRAKQVVPAAINSETMRKESAARLLELVAADQIAFKVTVGLLDEEQRSELESLLRAAGVGKRQEKSAEENVEARPAIELRMDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2K8</accession>
    <name>A0A1C1D2K8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ubp6</name>
        <name evidence="10" type="ORF">CLCR_02860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2K8"/>
    <dbReference type="STRING" id="86049.A0A1C1D2K8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02860"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05001"/>
    <dbReference type="eggNOG" id="KOG1872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="110"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT54910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="579" mass="64545" checksum="BB8CB7FD53CF78F5" modified="2016-11-02" version="1">MATIPIVVKHQGKKYDVDLDPSATGEVLKFQLFSLTGVEPDRQSLLIKGGKLKDDTDLSKLNAKPGQIFTMLGTASGEGSALIAPPTEKIKFAEDMTEAEAAAQEGATPAGLQNLGNTCYLNSTLQVLRSIPEMQDTLKIYKAESSTGSLQDLSRHGLSGLGASNDLTAQLRDLYKQMSETQEGLPPLMFLNSLRAIYPQFAQKAKNGHGYAQQDAEEAWSQIVHQLRGKLKITDGHTQDQKAIAFIDRYMAGSVHSSLAPPAEVGDNEPTVESDDTFLKLDCHIDQTINHLRDGILAGLTEEIEKRSPTLDRDATYVKTSRISRLPQYLTVHFVRFYWRKDIQKKTKIMRKVTFPEELDVVEFCTDDLRKRLIPVRDKVRNIRKDEVDVERARKRQKLAHKQEADRAHDEALKAVEAAPIAKLREHKEKKDSKSKEPEGGEMDVYKTDAEYEADRAASIKQAKKELFEVIDPELAADEGANKSGLYELRGVITHQGASADSGHYTSFVKKQARLVDDPKAPGGKRKEEDGKWWWFNDDKVSEVDAERIMTLAGGGESASALILLYRAIDLPTKDEIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2Q4</accession>
    <name>A0A1C1D2Q4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2Q4"/>
    <dbReference type="STRING" id="86049.A0A1C1D2Q4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02784"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05160"/>
    <dbReference type="eggNOG" id="ENOG502QW68">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT55067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="86195" checksum="CDE6DB2B46D9A15A" modified="2016-11-02" version="1">MDSLRQHVASVVGRLSPAHLQHRYQLLRQHEDLAHKSPVSRQVSRLRFRHPSQWSVKHRAIAVLATLIGVVLVFACPIVLSSGKRAPAASPRPQFAWQQFPLEKGYFGGLRKLVPARQGEQDDAQRVSSPGKGRTGMQYPDPVVYNPYSSSPPGSQQNTPAAEGCFLDEENTITPPVIWAYNGVPERAPEPMLGSHDVLGLNKDVCFERYGRYAAYGLGYHVGEGGTGLGIHGDMDGTDMTLNNDSRTDWRGVDLGRAQRMCGERNRHRFPPSPSPPFTDDVFHFRQTGTWPAPAPERASSPPPQPVSHPDPGLGYGGDSGDGSRDSNHPRIARTAIVLRLWDQYAWTNYSHLYVRSLVTELNLNAGAAYDIHLLIQIKDGSPIWASPDVHDAVLDRVVPREYRSMATLWSEDLLCLLYPGPFEPQFDRPGPIHSVGRSMHMALQWFATHHPEYDFFWNWEMDIRYIGHWYELFDRVDQWSQAQPREGLWERAGRFYIPSAHQGWESFANDTATRARNHTSSESDKHSAIFGPQTFPGWEEDDRSAVFGEDYRAKYGLVPLARHTESEAQPDEPADYITFLPQFQPAHTFWIFRADVSGYSTALPIPPRRTSIVTASRFSRRLLSLMHRETALARHSMAGEMFPASIALHYGLKAAFAPHPMYFDRRWNESAYVEDVFNGHPVTGEAGGYSESVFSEALQHNFRGGTYYYDAAFAGRVWRTWLGYRDGAEGGGPWERNGKESSGRMCWRSVLLHPVKWEEGDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C649</accession>
    <name>A0A1C1C649_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase chain 1</fullName>
            <ecNumber evidence="7">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ND1</name>
        <name evidence="9" type="ORF">CLCR_11471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="9"/>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000023">
        <property type="protein sequence ID" value="OCT43966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C649"/>
    <dbReference type="STRING" id="86049.A0A1C1C649"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11471"/>
    <dbReference type="OrthoDB" id="531329at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="NADH DEHYDROGENASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432:SF3">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 9" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT43966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="357" mass="39653" checksum="12A1CF4803158940" modified="2016-11-02" version="1">MYIFISIIEVILVVVPALLVVAFTTIAERKTMASMQRRLGPNIVGYYGLLQAFADALKLLLKEYVGPTQANLILFFLGPIITLTFSLLGYAVIPYGPGLSIGDLGLGILYMLAVSSLSTYGILLAGWSANSKYAFLGSLRSTAQLISYELILSSAILLVVLLTGSLNLTVNIEAQKVVIFALPLLPIFMIFFIGCIAETNRAPFDLAEAESELVSGFMTEHSAAIFVFFFLAEYASIVLICIFTSILFLGGYLTIFSLHSLLNILFYFNIELYFMNINMNIFIVMLQGLVYSLSLGLKSCILIFVFIWVRASFPRIRFDQLMSYCWTILLPVIIGLVILIPCIVYNLSLIPNNFYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6E2</accession>
    <name>A0A1C1C6E2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Peptide deformylase</fullName>
            <ecNumber evidence="2 7">3.5.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">def1</name>
        <name evidence="9" type="ORF">CLCR_00137</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Removes the formyl group from the N-terminal Met of newly synthesized proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal N-formyl-L-methionyl-[peptide] + H2O = N-terminal L-methionyl-[peptide] + formate</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2 7"/>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6E2"/>
    <dbReference type="STRING" id="86049.A0A1C1C6E2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00137"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02025"/>
    <dbReference type="eggNOG" id="KOG3137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276063at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="entry name" value="Peptide deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001159">
        <property type="entry name" value="PRK00150.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PEPTIDE DEFORMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458:SF2">
        <property type="entry name" value="PEPTIDE DEFORMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="Peptide deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="217" mass="24177" checksum="8E53EEABF35871E9" modified="2016-11-02" version="1">MTKTPTPPKGKIRPIVRWGTPILHRGVREVAPAEFDTPDLEALIADMFATMYAADGVGLAANQIGVDLKVFVYDLTDLKGQRSQDVVCNPVVQTRNSPQEGGGHHHAKREQQQQQQQQSMTEGCLSYPGVSASVARPRSITVRGTDQRGKAVEVDADGLLAHILQHETDHLNGIVYGDRVSSPEVRQRMDIDYQELERKMAYPENWPVTGTKQRWII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6H5</accession>
    <name>A0A1C1C6H5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_00727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6H5"/>
    <dbReference type="STRING" id="86049.A0A1C1C6H5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00727"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01015"/>
    <dbReference type="OrthoDB" id="5511599at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="136" mass="15497" checksum="B3D7DE76D1616FE4" modified="2016-11-02" version="1">MVHPTALRMMQATRAGMFRATQRAPAQQKSGYVAHTTKTPVSSSNYTAVLEHQSADRSVYRVLVFRENRVPYYQRLFQNHDGKRQWWKVSRSPFIQLFALHEDKSMSLKMADCGTANSRLSTRLTSTSSPNLVMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6I6</accession>
    <name>A0A1C1C6I6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_00636</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6I6"/>
    <dbReference type="STRING" id="86049.A0A1C1C6I6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00636"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01018"/>
    <dbReference type="eggNOG" id="KOG1479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="46396at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="465" mass="50542" checksum="81E30092FC02DB8B" modified="2016-11-02" version="1">MGLFRSRSRQEYQPVRGDTDADRDDESARDESETAPTVEAPFSWVEYMIFLLLGVAMLWAWNMFLAAAPYFQKRFSASQWILNHFQAAEVSVSTITNLGSMIILTKLQKGASYPRRISSSLSINIVVFAILALSTLVRSAAGVYFGFLLVAIFFASFSTGLIQNGLFSFASGFGRSEYTQAIMTGQAVAGVLPPLAQIISVLAVPTKKNKDNSGADTADASPKSAFIYFLTATVISVLALLAFFYLLRREANSRALKSAAKATGDEASEGDALTGAIRRTSAQDAPGEEANERPTVPLGTLFRKMPFLSTAVFICFAVTMVFPVFTASILSVNNIDSAIFIPTAFLVWNIGDLIGRLVTLWPKISLTHYPFALFCLAMARLLFIPLYFLCNIKNKGAAISSDFFYLVIVQFLFGLTNGYLGSECMMGSGEWVLPEEREAAGGFMGLMLVGGLTVGSLLSFLLGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6T5</accession>
    <name>A0A1C1C6T5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GYF domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6T5"/>
    <dbReference type="STRING" id="86049.A0A1C1C6T5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00545"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01105"/>
    <dbReference type="eggNOG" id="KOG1862">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48509at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00072">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="748"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1330"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1469"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="718"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="915"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="925"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1241"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1335"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1347"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1367"/>
            <end position="1377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1511" mass="159086" checksum="FBC56B11707C69BF" modified="2016-11-02" version="1">MPSPFAPTFASAAASTNGDNSGSRRDNAGSSEWSRRNVNGATQTFRRPSLATTPSQTRETGTASASATTPGGVYIPPHLSAANSTTSRNPPSGDMRYSKEQLLNIFQTLKETSALDTNLEDIFAGTWDPLDSKTGLGDQGAAGDGKDQTPGPEVCWNYAVNPEPFGLTNLTEEEKQLFSSSVNSPIKPQQNITKESTGVGVIGRKASLSTYSNTPGASRPGTRRRETSDSFMGNGPLSPVEGKTFFRTESNTATPPPALLRRRTDYKEEETTPTSKENQEPEDTPEPQPPLPGLRRAATGPLSAGGNPLSASPWSAGGQGSAFGSMGTFGSFAIGATGTPSESNDKRPGFGSARGSSRFKDILQSKASAEDVSQLAKDKGLFGALENLPEEDVGPRQARLRDELKTRPGRSETNPYEDDPMRTGSAALGGSQDPGPAAPGIEQMGMSAFGPHQSIGTRDFSHDDPYQQTPYGRAHNPHEPMSPTNTNPYQSPHGRLEDEQDTNDSASQASGLPHFGGAAPRRNMYPSTDEGRHSASGLRSVSGFGGLPGFGGLGGNPMWSAAGIGSGKPAMDRGITSAFGDPVFGPLSELQSPGGLGGGFGGFGSAGRSSRLGAMLPAAMQEHVRGDSRNEARSYDSRPESAQQHPLRDPFEVASRRHDDFARGSGVFDDSPSMRSVEEPGNGQYGLPGSGPPTSSVAISGAGPQTAGPRAGGSDNYQSGHGLSQSSGSSSSNQLPAAQQRQMVMPDRMRWIYRDPQGNTQGPWSGLEMHDWFKAGFFTAELQVKKLEDAEFEPLAQLVRRIGNSREPFLVPQIGVPHGPPTSGPGNTWANPAIPPTSGTTQPPFANSFPSFGTTLTAEQQNALERRKQEEQYLMARQKEHLAQQQMAMKMQMQNGMHSLQHHSSAHSLQSQPSFGSITSPTGYQPSPIQPMMQPQQPAPFTQHAGPVGGPAFGREDDVQNMMERLSFSQRAGLPFASAPLGPPPTEAGPSSQPVNTMLQDRARLQQQQQQADMRGHQEAFLGPQGRNERLEEFRSLRGQADIPAGRLGPDEPRQQPIGAPRPASEQPVPLASAKLPAPIGHPSAIAKPEPESLSLAQQVQIAAASQQAAAAEESEWAKKDTPIEHPPVSISPLPAPAAQRNRQHVADALAAESRSATQTPIETPVASVAPWAERTVEHPKGPSLKEIQEAEAKNAAVQEEVARRAQAEQERLALAQSQAPVPAPGLPSTSTWGSAASPGTPGSQTTSVWAKQTPAKVGAGASTAPKKTLAQIQKEEESRKQRAAAAQVVANAQNAANSAAAAVGKRYAELASKAAPAVPTSSGGAWTTVGSGGKAKAPPAVVATPQPVSRTVSTSNTPKTRPAVQTARSTTLPNQSKANEEFTKWIKGVLGKGLNAGINLDNFVQDLLQLPPEIEIISDSVYASSQILDGRRFAEEFVRRRKLADKGVIESAAGAQPMMGIGAGADTKGAGGAGGGWSEVAKKGPANVTAAKEEGTAQFKVVPTKKKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6X9</accession>
    <name>A0A1C1C6X9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_00640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6X9"/>
    <dbReference type="STRING" id="86049.A0A1C1C6X9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00640"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01159"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034276">
        <property type="term" value="P:kynurenic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="34"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="422" mass="47331" checksum="68EBCEF9482F92B2" modified="2016-11-02" version="1">MDAKFAPAKRVAGQKQDVWSIVNEAAAASPVQPIVNMGQGFFGYNPPQFIIDAAKSALDRVECNQYSPTKGRPRLKKAIADAYSPFFGRTLDPETEVTITTGANEGMLSAFMGFIEPGDEVIIFEPFFDQYLSNIEMPGGTIRYVPMHPPKDGAERTSSAANWTIDFDELAKAFNEKTKMIVLNSPHNPVGKVLNKEELTRIGDLCLKHKVLILSDEVYDRLYYVPFTRIATLSPELAKITLTVGSAGKNFYATGWRVGYLIGPPELIKYVAAAHTRICYSSVSPLQEAAAIGFEQADKVGFWDQQITEMKGKVDRFCEVFDELGIPYSIPEGGYFILANLSKVKLPQGYEFPDHVKDRPRDFKMSWFLIMELGVAAIPPTEFYTEERAHLAEDWMRFAVCKNDDILEDAKKRLRGLKKYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C796</accession>
    <name>A0A1C1C796_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-rhamnonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rhmD</name>
        <name evidence="6" type="ORF">CLCR_05873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C796"/>
    <dbReference type="STRING" id="86049.A0A1C1C796"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05873"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07035"/>
    <dbReference type="eggNOG" id="ENOG502QRKX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17395at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050032">
        <property type="term" value="F:L-rhamnonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03327">
        <property type="entry name" value="MR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000005">
        <property type="entry name" value="Putative L-rhamnonate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023444">
        <property type="entry name" value="L-Rhamnon_dehydrat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011968">
        <property type="entry name" value="PRK15440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00006">
        <property type="entry name" value="rhamnonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="170"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT44338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="439" mass="48602" checksum="7D2FDAFF6D74E4CA" modified="2016-11-02" version="1">MSGLKSFPTIKAVRTFVIEGVGSGGDYHNVKGGHWLIDNKIATPMSKWEQYRSSRTSFGINVLGSFCVEIEATDGTKGFATGFGGPPGCWLVQQHFERFLLGRDARDVNDIYEQMYKASMFYGRKGLPVAVISVIDLALWDLLGKIRNEPVYKMIGGATRDKLNFYCTGPEPAAAQKMGFVAGKVPLPYSADEPDSIKKNIAFLKKHRQDVGPDFPLRVDCWMSLNVQYTIELVAEAKRQDIRIDWWEEVLSPDDFDGFQLLKRAHPDTKFTTGEHEYSRYGFRKLLEGRNVDIIQPDVMWLGGLTELLKVAAMAAAYDIPVVPHASGPYSYHFVVSQHNSPFQEYLANSPDGKSVLPVFGDLFLNEPIPVNGYLDISVLDKPGFGLELNPNARLVDATNLLGMRPQKSLTAPAEQEQASTNGTHVNGDHAPVGANDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8U7</accession>
    <name>A0A1C1C8U7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8U7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05642"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07576"/>
    <dbReference type="eggNOG" id="ENOG502RW27">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF7">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="159"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="421" mass="46448" checksum="1E1103603156887D" modified="2016-11-02" version="1">MLRKRDQNLNRGSHLQSGFDFLQMSSFQRHLRIQPIYCFGHGFIVASYDSKKQSTSSAHIPIASGDTTMAANKSSITIDPSKKQSPLRDEKQGASLKDRLPRPKSSQTHPQRSPSITDDSNASLFFVGTATTILEWEGLRLMTDPNFLHAGDHVHLGPGVTATRRTNPAVNLEDLPPVDLVLLSHYHADHFDQKVEAELRRDLPIITTPHAHEHLAHKSGGEAFTSVHALDAWEDMLVHVASPSSPPEGRLPRLHVTGMPGKHIGDGLLAKANDILGAVPPTNGWMLELGYAADAAGEDPDAFHCGYRIYISGDTLYVHELEKIPELYTHAGKPIDLMLVHLGGTTVPGPHMPLVMVTMDAEQGLKLVQLVRPEVTIPIHYDDYDAFLSPLSDFRTAITNGNLTDKVVYLDRGDEFKFTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8Z4</accession>
    <name>A0A1C1C8Z4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide-binding protein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_05909</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8Z4"/>
    <dbReference type="STRING" id="86049.A0A1C1C8Z4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05909"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07595"/>
    <dbReference type="eggNOG" id="KOG0286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="150"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="191"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="353" mass="38940" checksum="3B35FAEF8D7F925A" modified="2016-11-02" version="1">MSNDLTGEQMQAKITAARREAEGLKDRIKRKKDDLADTSLRQVALNNTEALPRIGMKPRRNLKGHLAKIYAMHWSTDRRHLVSASQDGKLIIWDAYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLSTREGPTRVARELSGHSGYLSCCRFVNDRKIITSSGDMTCMMWDIETGSKVTEFADHLGDVMSISINPTNANIFVSGACDAFAKLWDVRTGKAVQTFAGHESDINAIQFFPDGNAFGTGSDDASCKLFDIRADRELMSYQNEQVLCGITSVAFSVSGRLLFAGYDDFECKVWDTLRGDKVGSLNGHENRVSCLGVSNDGISLCTGSWDSLLKIWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9I7</accession>
    <name>A0A1C1C9I7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_05790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9I7"/>
    <dbReference type="STRING" id="86049.A0A1C1C9I7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05790"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07794"/>
    <dbReference type="eggNOG" id="ENOG502QPSW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT45129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="521" mass="57258" checksum="2BCD8DAE6844A6D7" modified="2016-11-02" version="1">MDQDLNKYLATEVLSEQRTISYRNVSRVFKVHVNAAKCILYEFYEFQNGKKPGSIYATYLLSGIKKRPTPTVTANATTNGQGQGHGRDFDPDEHIPSSPPPFTSSMLEPSQQSSQAGEEEEEEEANNVLVRTISLVKEDALEELKEQYETITSIHIYSLSPTRIQDLFTLSDIGRNLFNDVFVEEDPLQHNKTYGVIQNPNVRRRKGNRPAIPSGPAPKFQPVKEEAKKASALQSKPAPKSGPAAGSTKAEEPSRPSSRDSTSTTTSSKPSKQPPLKRDSSDLFKAFAKQGHKKSTPTSTPKVAPQDATMKDVDDDEGESEDEALFLDTNTRKPVSSSKKRPSDVKKEKEDRAAKLRKLMDSDDEEVAAVPNVGKATGLESDEPVAAQRGTDADVPSKDAGEDEQIAWSESDGEKKKKPAVPNKIEGPPKRRRGKRKVMKKRTTKDEDGYLVTKEEAVWESFSEDEPEPAPARNEMPKRSFGPAKASSQSQSQSQSQGKAAAKKKTTGGGNIMSFFGKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9J5</accession>
    <name>A0A1C1C9J5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TUF1</name>
        <name evidence="11" type="ORF">CLCR_05829</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9J5"/>
    <dbReference type="STRING" id="86049.A0A1C1C9J5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05829"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07860"/>
    <dbReference type="eggNOG" id="KOG0460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="49"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT45203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="440" mass="48642" checksum="2F2B1FE26BE9EA2D" modified="2016-11-02" version="1">MAFSRSVTSLLRTSRHIVSPARGLNPVNRVFGHDRFGARTYAAVFERTKPHVNVGTIGHVDHGKTTLTAAITKRQAEKGMAQFLDYGKIDKAPEERKRGITIATAHIEYETDNRHYSHVDCPGHADYIKNMITGAALMDGAVVVVAAGDGQMPQTREHLLLARQVGVQKLVVFVNKVDTVEDPEMLELVEMEMRELLGSYDFDGDNTPIIFGSALCALEGKRPEIGTEKIDELLKAVDEWIPTPARDTEKPFLMSVEEVFSIAGRGTVASGRVVRGILKKDSDVEIVGGREEVIKTKVTDIETFKKSCDESRAGDNSGLLLRGVKREDIRRGMVIAVPNSVKAHQEALVSLYILTEEEGGRKSGFTENYKPQVYIRTADEAAQLKFPEGTEDTSRMVMPGDNLEMVLKTHHPVVMEAGERFNMREGGRTVATGLITRILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9R4</accession>
    <name>A0A1C1C9R4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein mL38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_05913</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9R4"/>
    <dbReference type="STRING" id="86049.A0A1C1C9R4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05913"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07865"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1180:FF:000001">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000004">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT45208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="417" mass="47544" checksum="A4650EAA66E477E6" modified="2016-11-02" version="1">MAPSRAPSALVLHSLRSLNIEACSPRAALRPFSTTSATCQEVQVQKPSYYHNPDPATVHVPRLERKLIREGKFPIGSRRRRAALAHSPGIPFDELPYQCFQEARKILIADRAEKLKKIETERARIARLQEVDPSTFPGGDAYKQRRLRSMTQELEKLKILADINDPNVKRRFEDGQGDLNKPIYRYLADRKWREYPRKVLVQRITQMKVVPDVIPNVDPILDVKIVFGNRVVQPGEFVESYISENPCRLTLQSYERGEKMITIAVVDADVPNVETDGFDFRCHFLASNIVISPTQPIVDLGSLSSESQVLLPWMPPYAQKGSPYHRLSIVILQHKDNIPIDLEIAKKKIQRDGFTVRSMMSRHMLSPISASLFRTQWDDSTAAVMERAGIAGADVELKRKKVEPLPYQRRDTSRMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAG3</accession>
    <name>A0A1C1CAG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peroxin-16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAG3"/>
    <dbReference type="STRING" id="86049.A0A1C1CAG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01576"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03450"/>
    <dbReference type="eggNOG" id="KOG4546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2021143at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="445" mass="49877" checksum="EB29CA53AFE4BBA3" modified="2016-11-02" version="1">MASTAASSIRRGVHTTIHCLSSASAELTKAAINLPSTYSNYVASNSSSVSTIESSLRSLTYLLPGARLHDTELASESVHTFVQLLSIYHDHILKNRAVILALSPIVLKAKNIKLQKPKPSLHARYTTFWTSSSSLYNKIATVLKIAQYTELLWEMIARRRGGEKTRWRVVVLLESFKAICRLLLMRLTNLRPTLTPPMPLREDFAPTSPEQQEEEFVEEEYAPDNFDVKNVLGDAGVPTPPLSDSGKQAPSSLSVNEPYSMPRTGLTLPTLPSPETVSAYLLNHVLTADDVKPAKQLLHRLTTMRGQAAEVLYTLRPLIYALLMQRLARTYGYEGSKWKRHWTPWLVGVSIEYLARQLAKRDLAARVPGGARTGLSALEREELKKRGWNLAWWGMRGAFYENVTKGWIHGAAESLKGKPLLDLVGGIIEDYEYLWSNYYFSTSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAH3</accession>
    <name>A0A1C1CAH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_01738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01738"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03380"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT45468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="136" mass="15388" checksum="58F75B0192D61226" modified="2016-11-02" version="1">MSCSSGYVAMQIHRCRHDYAATDGFSNAAKKFRLDVFDSLHAHGAIDNWVMPIGLNNIGWKMYIANGSWDIIAVVLIAVFWVETKGRTLEEIDAIFERHKHSHVLDVELVRRGKAQIDVGQVEQEIHTVVQATKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAL4</accession>
    <name>A0A1C1CAL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAL4"/>
    <dbReference type="STRING" id="86049.A0A1C1CAL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01744"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17006" checksum="CE1E03AF30C5E87A" modified="2016-11-02" version="1">MEKCRKRDRVPKMTTNIPQSALLVVDMQVLFVDTLVFLEPMTTAALVHFFKLCEHFCREPAPIVFTKHGHAKVQDGCAHSTVILSQEEASMGRQEKSLHDLCEHVALLPLPPPSRYRRRGGACCFEPLNVLWVLVAVTGLSLGWKEPPSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAX0</accession>
    <name>A0A1C1CAX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclopentanone 1,2-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cpnB</name>
        <name evidence="9" type="ORF">CLCR_01447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAX0"/>
    <dbReference type="STRING" id="86049.A0A1C1CAX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01447"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03591"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT45693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="616" mass="70277" checksum="7A8624CE5BB08731" modified="2016-11-02" version="1">MKRDISNVAPATNGTHDADKAHTNGDHTESQPLDMVIVGAGFAGVYLLHQLRRRGFKAKIVEAGSDLGGIWYWNRYPGARVDSQYPVYALSIPEVYKDWTWSSHYPDHAELRAYFEHVEDRLHVKKDCVFDSKVTAATWDDTTCLWTITCETGRTFTTRHWTACTGFAAKRYFPAWEGLDDFKGVIHHSSFWPKEGVDVKGKRVAVVGTGATGVQITQEWAKEIGPDGHLKMFQRTPNYACPMNQVFMTKEEQVKLVDELADRFAERNNFYNGFLYQWRDNLTFDHSDEERREFYEMLWKMGGFRFLMNNYYDMTRDSVANQTAYDFWREKVHARVHDARKAELLAPKEKPHLFGGKRLSLEQDFYDHFNKVLIRPPSFPLRLAPSLISLGADHFDCIKQDKLITSPSTPELVLQMLMPSFDQPNVDVIDTRTNPIVRFTPDGIVQEDGTFHALDVIALATGFDSITGGLKDMHVTGVDGVVLADKWAAGTWTYLGISTAGFPNFFFTYGPQAPTAFSNGPSCIEIQADWIVEVLEDMAARNLRKMNPQRRAEEQWRELVFELINDTPRGKVDSWYNGANIPGKPREHLNYAGGIPRYKKTLEEVKKGGYEGFELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB12</accession>
    <name>A0A1C1CB12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">erd2</name>
        <name evidence="12" type="ORF">CLCR_01662</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB12"/>
    <dbReference type="STRING" id="86049.A0A1C1CB12"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01662"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03547"/>
    <dbReference type="eggNOG" id="KOG3106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045015">
        <property type="term" value="F:HDEL sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT45642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="214" mass="25025" checksum="1CE8521C75E79477" modified="2016-11-02" version="1">MNLFRLLADLSHLVSIFILLHKMKVSNSCSGISFKTQALYFLVYVTRYLDLFWTFTDSAWNTMFKLIFLSSSLYTLYVMLNDYKPTHDPNLDTFRVSYLTGGSAVLALLFPYRYTIPEILWAFSIWLESVAILPQLFMLQRTGEAETITTHYLFALGIYRALYIPNWIYRWFAENGHFDPIAVVAGIIQTVLYSDFFWVYYTKVLKGKSFKLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBI6</accession>
    <name>A0A1C1CBI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uroporphyrinogen-III C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MET1</name>
        <name evidence="17" type="ORF">CLCR_00042</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Siroheme synthase involved in methionine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32459"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000018">
        <property type="protein sequence ID" value="OCT45910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBI6"/>
    <dbReference type="STRING" id="86049.A0A1C1CBI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00042"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00063"/>
    <dbReference type="eggNOG" id="KOG1527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="508204at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000504">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000005">
        <property type="entry name" value="Uroporphyrin-III c-methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012066">
        <property type="entry name" value="Met1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036555">
        <property type="entry name" value="SUMT_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="2 12 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 12 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="16">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="15">
        <location>
            <begin position="227"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="14">
        <location>
            <begin position="288"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT45910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="598" mass="65152" checksum="662BB0E8B7F7B3BF" modified="2016-11-02" version="1">MVAPALLTAQNCVDQIHLVLGSGPLAASRCVKSLEVGARPVVVFPESEDVHFTLAAAVEQGRVQWLQREFQQEDVKRLGREEVDGYVDAVFVTLPAKDPRSVEISSLCKRLRIPVNVVDAPHLCTFTLLSTYSDGPLQIGITTSGNGCKLSSRIRREIAAALPPKFGAAVERLGTVRRQIWHEDYKSQTACNGNTPDGEAEDEEAAAQKHTFNSLVKEDDRDPAVLRTRRMRWLSQICEYWPLGRLAAITDADVAAILQAYRTTAQTPAPGSDEISTLLPMLPPRRGTITLAGSGPGHPSLLTIATKTAIETAHFILADKLVPAEVLELIPRRTPVHIARKFPGNADAAQDEMHELALEAMQQGKNVLRLKQGDPYLYGRGAEEVTFFRERGYDVRVIPGITSALSAAMFADIPVTHRAVSDQVVVCTGTGRKGAAPEPPSYRKSKTVVFLMALHRLDSLVKSLIEDQDHEAPRRARWPSNTPCAVIERASCPDQRVIRSTLQHVCQAVEAEGSRPPGLLVVGHSCEVLHKSRDGKSWSVEEGFRGLDAVGSSPSEFDVLKELEASPTKDINRQPEVTGGSHPPLLHPVIAHPGITAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBT9</accession>
    <name>A0A1C1CBT9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase-like 1</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cyp15</name>
        <name evidence="10" type="ORF">CLCR_00410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBT9"/>
    <dbReference type="STRING" id="86049.A0A1C1CBT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00410"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10064"/>
    <dbReference type="eggNOG" id="KOG0882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="470"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT45941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="616" mass="68508" checksum="D0530B3388A41178" modified="2016-11-02" version="1">MSDTQSRKRSRSPDSAGSDSESDDDFGPALPSSVPSKKKRKLPHESLYVDALPKGLKYSKSLMHKDQLVSVTVAPSPVDFVITTSVDGVVKFWKKIATGIEFAKEYRAHEGRILSSAISFDGAFFATAGDEDDNTIKIYDVVTFDLLSILNLESAASCVSWVHRRGVSPTLAVAIGKQIHIYDASGDMQAPMHTLSSIHRAPVVAMAYNPAFDCVISADASGMMEYWQPNDTYEKPDSVFKMKATTNLFDFKKAKSAPCSIAISPSGHQFATISFPDRKVRVFDFASGKLYRSYDESLETIMAMQQAGTSLQKLDEVEFGRRMAVERELDNPALRSRINIVFDESGHFIAYGSLLGIKVINTLTNRVMKAYGKDEPFRALHVALYQGAPQKKDVVTVSMAASANPLLNDAEARDPILFATAYAKVRFYMFTNEEDISKSTRDVQNEKPRIIGGKKKEEKKTESGTSAVLHTTYGDIHIRLFPDKAPKAVENFVTHSRNGYYNNTIFHRVIRKFMIQCGDPLGDGTGGESIWGKEFEDEFSDLKHDRPYTVSMANAGPNTNGSQFFITTEKASWLDNKHTIFGRAYQGLDVIHQIENAKVRKEKPEEDIKIVNISIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBV0</accession>
    <name>A0A1C1CBV0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00537"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="97" mass="10494" checksum="EED9B9874819B141" modified="2016-11-02" version="1">MHARTRYLGTYAQGLILTVIIITAIIIITAIIITAIIITAIIITAIIITAIIITAIIITAIIIIIIIIIILIVIPALDRVRQHNVPTYLTSPKSPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBV2</accession>
    <name>A0A1C1CBV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ytm1</name>
        <name evidence="6" type="synonym">YTM1</name>
        <name evidence="10" type="ORF">CLCR_00457</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBV2"/>
    <dbReference type="STRING" id="86049.A0A1C1CBV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00457"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10057"/>
    <dbReference type="eggNOG" id="KOG0313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110136">
        <property type="term" value="P:protein-RNA complex remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="9">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="106"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="202"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="276"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="363"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT45949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="463" mass="49673" checksum="2B662769E1FE1370" modified="2016-11-02" version="1">MAAMSGADAPGNQAQVRLRLTTRDTDLALEDNAVILVPTSFRRLTLSTLVNSLLKTEKAIPLEFIINGTYLRTTLEEYLTSNGISAETTLAVEYLRARIPPQHVASFQHDDWVSDVDVMSTTSPRILSASYDGLLRVWNTSSQVLATSCGVGQGGHGSFIKSAKFISPIQLVSGSFDRALRLWKYSEDQDGFSATLSPQVELYGHKSSVESVCAHPASSRILSASSDHSVGLWSARKSDAPAAPEALAPKARTKDGKKRKLHNEVSVSQRGPLALMQQHTGPVSGAMFDLNDPTVGYSASWDQTVRTWDLVTASLVDTRTTSSALFCIEHMPALHLIATGTVSRVIKLVDPRASAATVTAMTLKGHKNAVVSLARDPTNDYTFVSGSHDGTCRVWDVRSTKQEKEGAVGQSLYTLARASLRGAPSPATGDGVKVLGVCWHPDVGILSAGEDKAVQINQSDAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCE7</accession>
    <name>A0A1C1CCE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell pattern formation-associated protein stuA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Stunted protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_01072</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCE7"/>
    <dbReference type="STRING" id="86049.A0A1C1CCE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01072"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09373"/>
    <dbReference type="eggNOG" id="ENOG502QPWC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0183">Conidiation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="10">
        <location>
            <begin position="108"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="441"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="587"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="264"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="683"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="813"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT46146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="895" mass="97637" checksum="2475F6BBF5ACEF3A" modified="2016-11-02" version="1">MASGGIYAQPPPSFPQHGHSNSMNAPFPQDPSSMGPYEAQSVASTPAPTPLPPRPASQHHQQGQAQQQQMAYSTNGGMMAAPNSFGGYSEANMFAQPNLYSNGVKPQIYTAVYSNVSVFEMEVNGVAVMRRRADSWLNATQILKVAGVDKGKRTKVLEKEITGEHEKVQGGYGKYQGTWVNYQRGREFCRQYGVEQLLLPLLEYEISSDGIPGASQGIETPTKEQAMAAQRKRMYGGDGRPPGQSVGGTFFKNMSSTAANAIHALNRTRLDSPNMDGRRSAGPRRPSQPFNYGQEPMYGSQQSMPSMTTQDSFGTNGGIMSQGASFAEFPNTDAQEPPRKRIRPSPQSSFLYDGAIDLSMQDGTPTEPNVSFFSQPSQSFIASDPLHYGLEPLPHPSGPLEEQKKDLLLELFIDPERTDFDDHPAFLRLSGDEFEMPIDGSCNTALHWAATLARIALVRKLLDKGFNMRRANSGGETALIAACQARNNLDRNSFPALLELLGPSIEVRDGRGRTLLHHIAVSSAMKGRASVGKYYLESLLEYVIRQGTASQPIMSFEAMNGVNSQSQANPMTLARFMSEIVNAQDKAGDTALNLAARTSTTAIIDQLIEVGADANIANRGGLAPVDFGVQGQATGGITDPNLPNLFEQPSIANGSPQKSFEDAQEGLMTSIREVLSQSEADFAAEMKEKKDILDKTNAALKESGNALAEERRRLEDARVKVREKDELEQKIANLRQATAKLRAELSAMDPPATIQEHVAVGEADKGLDLDGQLPVIAQVLQNGEADPSNMALNQEQGNLLARLERAEVMSGRAKVYQRHNQQLEQTAKTLKARSSELEERYKKIVSLCTGADEDKVDELLDNLVQAVISEQKEMSNNSQLPRVREFLRLVQGSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCH5</accession>
    <name>A0A1C1CCH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF974 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCH5"/>
    <dbReference type="STRING" id="86049.A0A1C1CCH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01229"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09346"/>
    <dbReference type="eggNOG" id="KOG2625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250284at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 N-terminal" evidence="1">
        <location>
            <begin position="17"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 middle" evidence="2">
        <location>
            <begin position="191"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="307" mass="33486" checksum="E6177A908990E000" modified="2016-11-02" version="1">MARARADTGNFAKEPHSVSLKASLAYPAETADQEFVLSSSLGLPPSFGSAHVGETFSCALCANNELRPEQTLKTVSGTRILAEMQTPSQAVPLELHAAEGIADEDRPGSALQRIIRFDLKEEGNHVLAVNVSYTETTGDGQATSGRVRSFRKLYQFLAQPCLSVRTKATELETAEIVDKTYGPYGRTALLRYVLEAQLENVSDAGVVLEETRLQSRPPFKSTSLNWDAEEGIEDGGERPLLKPRDVIQVAFLVEQQEGVSDGLEDVKNSLRRDGRAVLGQLAIQWRTTMGERGALSTGNLLTRRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCJ5</accession>
    <name>A0A1C1CCJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01333"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09337"/>
    <dbReference type="OrthoDB" id="4158464at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="180" mass="19357" checksum="6D63DB764654D146" modified="2016-11-02" version="1">MPGPDVVLPDRTSRFDSSWSSPRTDISRFSSNGSLDNSIGASGHFGGHPAASLYINGMGHQFGPAEEEDDDNPRWADFISSGNSLDHMSFDQDSSGMVIPGLLDDSALATRGSGIGIAIDERSILSSEYESSFPQPSATASQVLTGVGTVFANHFLVRPLRLTPECRHSVDRPICARYMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCM1</accession>
    <name>A0A1C1CCM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_01335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01335"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09242"/>
    <dbReference type="OrthoDB" id="4140791at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="173" mass="20039" checksum="D65FD2EF242B734F" modified="2016-11-02" version="1">MTCMNSDVELAIAQMRNTFFDYEDWVRGRIRRSWAETLQKNMPSLPPEYQALHESITLPATRQVAIRLRQYLVYRSTKVNLNGPADLDHTEAVSTIFTTYSQYDFGVLINVYIHLVAGRVADMEKSSRLVEAALALTTLHVLRRGIFEATVYRCDHRSSHHIITINHLERTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCP9</accession>
    <name>A0A1C1CCP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HEAT repeat protein (DRIM)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_01026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCP9"/>
    <dbReference type="STRING" id="86049.A0A1C1CCP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01026"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09284"/>
    <dbReference type="eggNOG" id="KOG1823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="879"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1668"/>
            <end position="1885"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="4">
        <location>
            <begin position="2502"/>
            <end position="2574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2542"/>
            <end position="2589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2550"/>
            <end position="2559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2568"/>
            <end position="2578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2579"/>
            <end position="2589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="2589" mass="289103" checksum="47A1D0FC2FE0E1B9" modified="2016-11-02" version="1">MAPISPGFQLAPSRRAKKQTTSTNLHRYESFSRRIARLKIDPVHTVERRKPADDDADILQSFFRTALEEWAELNLSQTFTSFLNKASPLSETLPQLLHHADTVFNLLAEHIEKNDELALEPLLSLLAHLAHDLGQGFERYFSRTVELVARVAAAQDKADVIEWCFTCLAWMFKYLAKLLVRDLRPLLDIMTPYLSSKKDYIVRFSAESLAFLLRKAAVLYQKKRGPLSLAIRHLLEALPQDNTSPPYSPYQLGVMSLCVDSARGLDGQLHSCSASLVRCVLDTTLAMSDLSHVQSIVEGIMIGLIHETDSSSFRPVLEVLLEAMRRCASSKEANHVSLSVRLVIVLLGTRKGSRISGWADVIQTFQTLADAARQLIDELPLIHSTLATITAEILQYAPMDQLLPFSQELLDTAAEHLSSREYFAFSALSAELGKERFTDLVLPKLQQYIVDHWSDDEVSLYYTLERLRQGNIRIGGAAAAGSLACPADYEDFAVLRLAAEGEAGNPSTIQQLAGRLRLAKNSRLSRSPGVRGRARDAYYKLLGAALAEGGSELNLYRRTILGWGFDSYLDLVSDTDLQLEGLTGLLLETPSVHFRLEPFVHATVRLFRKHAPPQSSKLRTFDNLRHHLIKNLLANSAGLKKESLLLLSLVEASDAKPWLVETTDLLVEILDTPYNPAQVRKIAMLLRRLPQLHRSIPPESSYQDLIPFYSLGMLSAFHDKTRKELCSTLAQLVETSSTEEVVVNVAMQWLQTPVDPVQPQRKGEEQTKRHISSFECSHLAQVESLSSSVLSDFQNSDDRFLTMAEAAHQLENVAIPPNGRTLALQVLAAIPAMAERRSRLLVPVFLAAPFSRAQLPTNPDSDASVSSHTLTPELDDQAWSLSDRKALLTLFGKFVNPRVLFKSPEVYSKLIDLLSNGNDDIRKLAFHAVLTWKDPIVTRYEAKLTQLAEGKLASSDISTLLSSDEGSDSVKSEDREVILPIAVRLVYGTIVGRAGTQGAQDARRKSLLRSLFRLSKQEVALFLDVALGKLRDLNIKGNSPHLATLDQVFVPEDQQYGFLRLLLSMLETSQSQFADYGSQVVDAVVSCIVRASHQGQSQIGANPTPTTALARSIRRTAFQCLVLLFEHCRDIDWPLYLPVLFAGGISPRLDIFASETTQGISGLLRLFAVWAHSHDLVICLGKYDARVPDVLWRSLAAEPTPNTVKVFILTEIVLPWVELAEDSSITPNEAHDLLQTESDGLLRALISLLERTPPKDILAALTAVLPRIAPFARSLESRESTVKLLTSLLSNDGFKVAPNVKGQLLRSIQAFLTSEDALEAELRQQLLASVSPLFNYFKDETNRQILCEVLERLAASNELWTEVARLCKDLNAVSSHRLDELDYDTRLRAFHSVQALDFANFGQMCLPLVYNLLFFVRTGDDFSIRSNALGCLKQVIAKCCDGEHSEVNNMIVSSVLPVLKKGMRHESELVRADFVGLLGLLVQHAGGDEDLTNMTPLLVGNDEEASFFLNVLHIQQHRRLRAIRRLVSEVEKGAISVKNIVDIFLPLLEMFANETSTDESAQGTKGQAIAAIGTVLRRLDWKHFKTLFRRYKSDLDLTDNEQKSASRLLGHAADALVSASARRSSQNEERPEQPQLRLATALPEKGVVEQELRTQFIPKLTELIHYKDEAEISLRLPIAVITVKLITLLPAGEIPIVASPIILDIANVLRSRAQESRDAARRALCESVLLLGPSSLQFVVKELRTALTRGYQLHVVSYTLHAILVALSPHSKLGDLDYCVEDLVPVIVDDIFGTVGQEKDNQDYISSMKEVKSSKSFDSMELLARSVSIASVSKLVAPLQTLLSGSLATKQVRQIDELLRRIGSGVAQNPSASKRDILTFAYQLIQDLYRQKTSGRIQTLTSEEKNRQRYLIEMSSLHKTSESKTSTLLFKLARFALDLVRSTLQRHADVMTPENVHGFLPIIGDALVEGQEDVKISALRLLSAIIKLPMQELEDNAALYLSEAVKVVKNSTDTNEEGAQAALKLIAAVLRERKDVKLRDSDVTQLLHRVTPGIEEPDRQGVTFNFIRAVMARKIQTPEVYELADKIGIMMVTSHTKGARDVARGVFVHFLLEYPQTASRWSKQQKFLMKNLEYEYPEGRQSVMEAINTLVGKMKGDTAQELISAFFIPLLLRVANDENEGCRQLAGALLGRIFGLADRTRLNEVLQPLNTWAGQNENPALQKLGLQAYGILLNADVNLSKDELGLICSTLSKTLDKLDISDEDEWELPFQGLLLLQKLVDSHPEMVLDREQAHLWSFVWSILGHSNAWMQSTSASLCIQFFSHCLSGDRSKLPLACQYGMSMDSHAFLKVLKASVRVLRRTEGNENLSAQIVQILGFLGQCLDQNGLSMELHQKLVESEESEVDSEVESGDEKARTRTISGVQYLLDQLSRILRLEANRLSSAAFLPKKSALQLLSSLLPGLSEANLPKPQTYKILLPLQHMTDPNTIPPQSADPTFSATYQSLIELSHEVMDKLQKKLGDTEYVKALTEVSKIVRERREARRQKRRIERVAEPERAAREKKRKHDRARERKKEIGRTHQRRRREIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD27</accession>
    <name>A0A1C1CD27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD27"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11247"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09150"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="76" mass="8573" checksum="481AEF681E92678F" modified="2016-11-02" version="1">MVPKSRLIIVDQVMHEAGVLSGVEEQRASFNSLERDEEGWQSLIKQADERLELRSIREIPGNILAVLDVGSKQNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE55</accession>
    <name>A0A1C1CE55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_01839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE55"/>
    <dbReference type="STRING" id="86049.A0A1C1CE55"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01839"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01466"/>
    <dbReference type="eggNOG" id="ENOG502QUM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650813" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="30"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="712" mass="73528" checksum="6A25769B7A234FC1" modified="2016-11-02" version="1">MPSPSLFLGSSTTLVSALLLLSSSAAATSDTYYALDTDYSGRDFFDGFSFFTDADPTHGFVTYVDEATASADGLITTRGGSAQIKVDSTHKYNGSAPYSGINGVGRPSVRIESIDSWTHGLFIADIKHMPTTTDSSGCGVWPAFWTLGSGTWPYNGEIDIIEGANNQANDLTSTHVAGSCVISQNPSEMTGTSNGNDCQYNVATGANAQGCGAFSKSSVSYGAGFNSNRGGVYAMEWKSDAIKVWFFPRGSIPSDISSGNPEPSGWGLPDSIFNGPGCDIDANFADNRFIFDTTFCGDFGDATWQGGGCAAIESQSRCSVFVGDHPEQFTEAYWDVSYVRVYQSKPVTGHTSSSTTSTMTTSSSSTRTISHATTSEASTTESTTLPYTHSHTFGGQPGTTSAPATATTTWYTTSASPSPSTTAPYIHTTASSPGASSETTWAHSPTSGSSSSESPATTPGDSWEGTTSSFDWQDWESSTKPADPVTTSLTTSSINWADWELSMSSTSTPADPVTTSSSSSFSWADWEVSASSTSKPNDPVTTSSSSSFNWADWEVSTSSTSKPTDPATTSAFTWSDWSSDTSVAPISTATWSDWNSDPSVAPISTATSAWGSPDSKPSSPVAAASAGSSTWVSPSVTIATTVTVAPVASSAWVAAASATPVAPYSVPSDGTGSAGTTTSPWVAAYTGAAGRTGLNGLALLGAGAVAFGVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CER1</accession>
    <name>A0A1C1CER1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">alg9</name>
        <name evidence="11" type="ORF">CLCR_02360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CER1"/>
    <dbReference type="STRING" id="86049.A0A1C1CER1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02360"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02472"/>
    <dbReference type="eggNOG" id="KOG2515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT46946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="582" mass="65890" checksum="4A870CFA1ABB790E" modified="2016-11-02" version="1">MKSRVKGQPTPQPAPTKFDLPLDIAFYLCLCSHILAALYAPIQDCDETFNYWEPLHYLSHGYGLQTWEYSPEFGIRSWAYIALHAVPVKVASLFGRSKTFEFFTLRVMLALACAATEVRLYSTISRTMNPRVGVIYLMIVAFTPGFFYASSAFLPSSFAMNTSTLGLTAFMNWHGGTKTAAGIMWFGIGALLGWPFSGALIVPFVVEDWLIALVGQSDLFEASRRYLDGFVRCLVVLALQVSIDTFFYHKVIVVPWRIVAYNIFGGRDRGPDIFGTEPWHYYIRNLLLNFNIWFVLAAISAPLYLFQATNLRQHTTKQSILRTLTFLSPFYLWLGIFTLQPHKEERFMFPAYPFLALNAALAFHSLLAWIGSTDSIIFGSIPPKAKLAVILPIVLLSINVGLLRIVGTVTAYRAPLQIYDALGTLNTTHPADTVCFGKDWYRFPSSHFLPNGVHAKFVKSEFDGLLPGEYHEGKTGFGFFAGTWLVPPGMNDRNEEDPGKYIDVQYCTFLVDSYMPGMEATEHEPLYIADEEHWERVVCAPFLDASETGLLARTIWIPDLPVIPPRYRRHWGEHCLLRRRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEU1</accession>
    <name>A0A1C1CEU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02544"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02366"/>
    <dbReference type="eggNOG" id="ENOG502R9TD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4106306at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="328" mass="37881" checksum="CCDA3193A85347C4" modified="2016-11-02" version="1">MADSVSSHSHTLTARPYMFPPETRDPRLSAVVSRLSDLPAEIRLSIFEHAFRGNRVAVTAQSGCYCASSTTGPYRADHQWLLKLNAASSSSPTSWRQLQGEAQHAFVQIALWELHCKRAMVAFVRRMAMLRYLGEVRHLRLSVDEVEVNVEVNVDVEVAHDHTDAAQTDVDLHVYDNVWNPQRDLVVFPNLRSVTFAPWEKGWTITIPEQLGSRPLWDENVMPRVWHVLESKEAYRPLRETFADQARGYTLYFVFPICFHLPSSRPLSPPLRQRPRPWPREGNTNLDVDPPRLPLPRWQLCVWRANLDHGIIERDWREMHLAQEATLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFE3</accession>
    <name>A0A1C1CFE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_11265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11265"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650773" description="Secreted protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="12908" checksum="926B587E770041AC" modified="2016-11-02" version="1">MDALIVAILALLLGKSVTTTASPLDMFAARSGDVASGSTESGPVARVVVVASVNGEWGRHGSGPGPGLGLARGPARIPFVTLAVESSADGGSSTDGGSSADGGSSADGGSSADGGSSADGGSSSALLGDREADWDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFH0</accession>
    <name>A0A1C1CFH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02674"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="122" mass="13656" checksum="1F528A4EAF3694CE" modified="2016-11-02" version="1">MATPQTYTWGQMINTSPLHNARSIHNHESHRSVLILDFFQREPLQADELGDANIVTPGPIKVVRGDWTIAGSVGLRDPSALCKRIKSAEETTIWTSTRSSRFKAGNLGCQYGVWLCLNRAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFT3</accession>
    <name>A0A1C1CFT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">26S proteasome regulatory subunit rpn12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpn12</name>
        <name evidence="4" type="ORF">CLCR_03637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFT3"/>
    <dbReference type="STRING" id="86049.A0A1C1CFT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03637"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02000"/>
    <dbReference type="eggNOG" id="KOG3151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="73"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="272" mass="29853" checksum="FC9EC047D0D79A60" modified="2016-11-02" version="1">MSSQSPSLDSILHSLQQSLSHGDASQAQQQLQKAKIALLQQNALIPSPQTPVQTLATARSILEAGALLSIRSRDPQSFIRYYSQLQPFYDFPGLQQHPSKDRSKITGLYLLLLLSQGDYAGFHTLLESLIVAAGANGSAAVEGDPFIKYPIELERSLMEGSYDQVWRKTNGRDVPGEEFGLFSDILINTIRIEIASCAARSYPSLPIASAKNLLFLDSEGAVMEFASDQGWSLEDGRIHFPALEDAKKAQDGDQKEVISHMVGYARELESIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG17</accession>
    <name>A0A1C1CG17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03744"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="108" mass="12440" checksum="A00E9448AA0AE4C9" modified="2016-11-02" version="1">MGERRRNDHRVSRLEDLQECYWKTSKLNPASEKYWEVDSASDKQYGTYGILFNERVDTDVPTPDTRHQTPDTRHQTPDTRHHETLSGVHLMHASGPHSVTAIPSALLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGD4</accession>
    <name>A0A1C1CGD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_03588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03588"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01843"/>
    <dbReference type="eggNOG" id="ENOG502SN6X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G00100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="3">
        <location>
            <begin position="53"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="321" mass="34914" checksum="0F31AA35169D3B66" modified="2016-11-02" version="1">MARVLVYRGQPAKPVLPIWRDAALAHLRDSVKKLEVRASRSDLFRRFDTMTLNSTTKLSIAELAIYIVLIQPTLWLLYKHGRSGLMSFLYLIAFEILRVAAAGIQIANRNAAHPTESGAIVSSIGLSPLLLALAGFVDLLWLYYGAVDRSPVRARITAWGVHIGAVAGIALVAVGASKLFGQNATRSDITTGYTMLKVGAIMLLSTWMALTFVYLPLFGKLHSQPVLGVLMGLSASFIGVRAVYSVVYAFDHTESLSPFTGSFVVRLVLIFLAQLLAALSLVAVAFLTRNAGRKRAAGDRTRHQKGEDQDSSIPLTARGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGE7</accession>
    <name>A0A1C1CGE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sterol 24-C-methyltransferase</fullName>
            <ecNumber evidence="13">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Delta(24)-sterol C-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CLCR_03546</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the transfer of methyl groups from S-adenosyl-methionine to the C-24 of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="13"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGE7"/>
    <dbReference type="STRING" id="86049.A0A1C1CGE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03546"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01792"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000121">
        <property type="entry name" value="Sterol 24-C-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 12 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="3 12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="14">
        <location>
            <begin position="87"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT47594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="384" mass="43218" checksum="3E812A73208C8F8B" modified="2016-11-02" version="1">MAPAAISPVVSLEQEDHARDAAFNKALHGKSSEATGGLMAMRQKDRAAQKAAVDEYFKHWDNKAAKEETEEIRKARRDEYATLTRHYYNLATDLYEYGWGTSFHFCRYGYGESFYKAIARHEHYLALKMGIQENWRVLDVGCGVGGPAREIIKFTGADVVGLNNNDYQIERSLKYAKKEGIADKWSAVKGDFMQMSFPENSFDAVYAIEATVHAPSLQGVYEQIYRVLKPGGVFGVYEWLMTDKYDNNNPAHREIRLGIEQGDGISNMVTVSEGLAAIKAAGFELEFHEDLADRPDPIPWYWPLAGDWRYLATVMDVFTIARLTWWGRGLIHKFIGLGETLKVMPQGTQKTADSLALAADCLVAGGKEKLFTPMYLMVARKPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGK8</accession>
    <name>A0A1C1CGK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_03327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGK8"/>
    <dbReference type="STRING" id="86049.A0A1C1CGK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03327"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10389"/>
    <dbReference type="eggNOG" id="ENOG502SND8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="619"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="697" mass="76901" checksum="442481460FA15762" modified="2016-11-02" version="1">MFDGNIASNKKARKSTPKVRSGSTGLRASRKCEGYPEGARGLSAQPLPLEPASITAYSIPFKVPGSQADRQLLHYFCCQAAWNLSSGTDPTLWTELILQRANHQPVIRNALVALSSLHKDYLCGELAGPEYETPTPSTSLAPVANVKTMAVISRCHRQLRNYLARPDASPDVALVCSLIFYTFESLLGESQRAIWHLDQGLILLRKCQLDHSLASDDPLIPHLSTLLHHLDLQASCFDDRRPPLLRLATDAETKGHVDIVPDTFLDLTHAEAVLTKIQNWALHHLVNYVHYRGAGVEELPSESFVERLVLAAQLQKFETVLDRFAYHGSSISNTATHNQREDRRQQRTQRLLLLRVNLHTFSYLVKENLPLLTADAYDMAKKVMALLPGFSERPLAQMVLSGGETETDLESALASIEALLSQTWPLPDSAATGAGTTTTSATPARPYTLSTHLIAAIYFLSLKTTNKQIVEKATALFSHPQLRHARDGLWDARTAAFLVKNLVRVRQNGNVTEGRDASDILMHIAEQDIGVDIAQLQRIFHMSEKAGLPMMQSKKFTLVLRKGAVVRKHIGQEHTVSSCAYSSTPTSATVKRDAHDVHAPVHGFEHQQHVAGARRHTLPTDHLAPMPVPPRRTPSKTGPSRAQGKFGPQTQPEGTANVSPEYPDWNAGIHVSSDPSAVFKPEPYPTPAAVTTRPFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH04</accession>
    <name>A0A1C1CH04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sin3 complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_03311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH04"/>
    <dbReference type="STRING" id="86049.A0A1C1CH04"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03311"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04609"/>
    <dbReference type="eggNOG" id="ENOG502QT8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19806at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STB6-like N-terminal" evidence="3">
        <location>
            <begin position="58"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="786"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="842" mass="93931" checksum="019574D0D3F6881E" modified="2016-11-02" version="1">MSAGFLTPYHHAYAFGGSPKERSNRPSYKDEYKTAKPKEPAVSSPTSGGSHPGRQSRKRLVFADPVAFRYLEEDPATDAIERWRRLEGYEIYLVEQWACSRTHPTFIICTYTGDPSHSILVNVLAVPSDETTWSPRLQIYFQAVSQYHAKEKDTPLGSLMVTNLSGFPSALTVIPVPDGDVRKHREDFIVNEDLKRMGCAGRAAINLQPPQSSTIAKFHHLYKTSETVPLYQSVMELVRSCQIALVMYDKIQPTYADGLLCDVTERAVNDWWTDIGTYFYNVEPNDGILGPTTVAAMLGLLIGAHNRLKAFGCAVGKDALDTVSMKRAIGHFQKGQKMEKTRRLDRETLDRLHRATAKNAAGEGWTVPKAVKSTVAELSGKGGEMVMGIVGGRDKAGISEAETMDIERFAQLVTGPKMKWLWQGKPIKSGDPFAWPTEDLDLKGRVFSTDEQGNFIWTGNQHDSISDANPLERTDTMYTNQTDPKSGRHRLRGAVGGLKSSNARYQESQDWVDSTTTAGSRTSPRDHTHRTNTGLPRLTSPPAFDMDLANAEPSSPGAGRRQPPLRRNQTATEKKIPPHREQLRPALPGDSPRRKKAEAQLAELRNEFKADIYRKFSAAMPYKGPSSRALRRTQSNLQLTGHTLESPRQFRIPRRLSFSIVESAVLDTGESVVEEGIAKGKIEGDLTNALAERDALAAAAQKKAKRIQQIQQGLVPYTESRVAHVESLDAAAHDHLEQLNELYYHRLEEYQTLQATSSDIVSQEKSALTESFRRMEMLGAKMDYELNSLQSRLQEVEDGVNDFERNVVAIESRVKELHGENGAQEAHQPWIARVLNLLGTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHX0</accession>
    <name>A0A1C1CHX0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">YPI1</name>
        <name evidence="5" type="ORF">CLCR_04366</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the YPI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHX0"/>
    <dbReference type="STRING" id="86049.A0A1C1CHX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04366"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08271"/>
    <dbReference type="eggNOG" id="KOG4102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT48119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="202" mass="21439" checksum="3F8B5C36B49E59CC" modified="2016-11-02" version="1">MASARSAARPSGRAHLTPGQTASRRAAVGSATQTITPEDTASSRSVSPDPLVLRLRGAHDATSSSPHTHTHNHTRRRIQWAEDVVDNEGLGRKSSKVCCIYHKERAFGESSSEDDSSSDSSSGDDDSDGGGSDSPDDGAARMSGNRRGRKDARGHQHRHSDECGHGGGSGHGKGKGRRRPSPNAYEKMPKYTTKGKGELVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI02</accession>
    <name>A0A1C1CI02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI02"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04306"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="250" mass="27419" checksum="887584F90EF9EF0D" modified="2016-11-02" version="1">MSRSGMDGGPAVGTSWDPQRQPEAVARTSSPNDESDLPIAAGDSGRGHPAAALYGKLALCRYCPVRRISSTTSQKEQWAQILVTMRTTYLFCQAISLLTEPGDVQTEDATEDLEMITRVPLQPRRIFVLQRYEVRSGGTDPGTTHYGSRVGGICQRQALCPCPAQDSRYSSWSSDMMLCEKIVRQTSLGRRSGREMARRTPNSQAPVFGGKAIASLHDDGNRKDEWGRAVTRRNEASTTLNTDPRIKGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CII4</accession>
    <name>A0A1C1CII4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vacuolar cation/proton exchanger 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CAX5</name>
        <name evidence="11" type="ORF">CLCR_04000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CII4"/>
    <dbReference type="STRING" id="86049.A0A1C1CII4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04000"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08431"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000026">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000027">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF14">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="120"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="336"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT48286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="536" mass="57350" checksum="70ED8DC417A0BAA6" modified="2016-11-02" version="1">MSRQDPAPSNTTHGKSPSSSTSPLVHHTNSNSNSNNSNSHNSHEHPSHSSSHHTGAGGLLTIHHEGESGRSGMHLRSFAYILWRSSSQVSMLVNVLWPFVPAAIILHYLPGDHSATLDKWIFATAYVGMVPCANLLGFAGQELARKLPKVAGILIETALGSIVEIVLFMILIAKHREAADDDDDDTSAEEGNLIPVIQAAILGSIVTNLLLCLGLCFFVGGLRQHTQTFHAVVSEVGSGLLLVAGFGLAIPSAFYSALKGETTGHNFTRQKLQDDVLQMSRATSVILMVAFAIYIFFNARSQHGIFDEILEADERQDADHAHDLAKEKLTFTECVVAIAASLTLVTLLAVFLVERIEVIVRTGGVPDQFLGLILLPLVEKAAEHLTAVDEAWDGQMNFALYHCLGPSIQTALFNGPLVVVVGWILDKPMDLNFEIFMVALLVLAILVVGNFLRDKESNYLEGALLVIVYIIIAIAAWYYPDPDVATSNEFDGIGAGAAAGAGASASASAILAASNALKVQIPSPSASSLLQLRVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIP7</accession>
    <name>A0A1C1CIP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04386"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08526"/>
    <dbReference type="OrthoDB" id="5408734at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="128" mass="14570" checksum="A93A6B6A691F4165" modified="2016-11-02" version="1">MSTANEQNPDAGFQPNARPQSTIALDFSAALDDLFKLNGIDALEESVEQKKETVNHRKYELEDLETKLREADTKLQHLKAKHQRQQSQQVFTKRKPVFSPTSPEPEEDSSGDSDRGRSPQQYRGVETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIY1</accession>
    <name>A0A1C1CIY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose-methanol-choline (Gmc) oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_04005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIY1"/>
    <dbReference type="STRING" id="86049.A0A1C1CIY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04005"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08532"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF134">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="97"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="501"/>
            <end position="502"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="569" mass="63009" checksum="4244A51A5293C8B0" modified="2016-11-02" version="1">MSSTLPDRFDFIVVGAGPAGAVLASRLARSNRKPSVLLVEAGGKNDSKAVRADAERWLHRMVPGMNWGYQTAPVKGFDGRVISYDRGKGLGGSSAINFSVWTVGPKGDYDELARLVGDEEWKWSNVQERYKRLETYHGDAGDDVDSVRHYRDADPKNHGYDGPIHVGFPKVWEPQGKELMDIWYANGAKHNLDHNSGDPIGLALCISTAYKGVRSTSADALIDAPSNLHILVDTQVARVVFEGTKASGIRTLDGRTIHADKEVILCAGSLDTPRILLHSGIGPAEQLKAFNIPVVKANDNVGAHLKDHHHITIPVIRANPKDERTKFYKSKELQAAARALWEKDGNGPLSEYATTLGIAYEKIDHIAELPEFQALPKEEQDHLLEPTVPHYEYILNGPWLPHFIDPENAETGVTVFVFVLNQKSSGSVRLQSSDPAQPLIFDPNWFSHPFDRRVAVEATRKTLKIMNSPQFHNGTVTIDGPKSESDEDILAYWRGRSESTWHMMGTARMGKDESRAVVDRNFKVFGVERLRVADMSVIPIVSNNHTQTTAYLTGLTAADKLVREYGLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ44</accession>
    <name>A0A1C1CJ44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_04171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ44"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ44"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04171"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10294"/>
    <dbReference type="eggNOG" id="KOG0713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF10">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ A6, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="378" mass="44873" checksum="ADFF945372E1E1C8" modified="2016-11-02" version="1">MAPSPITEDYYMILEVEPTAEPQLIAKSYRRLALKLHPDRNDKRDATEAFQRLGRAYETLKDEVKRRADDLIYPSLKTRCPQIPCPTSRPEAFSEAAQLAAIQKSRQERSTRWRTQKNALDSSIFDLQRRVRQLEQEIRNLDSILVAEMAAEAQKNSWGTWLLLPFYNKVEETASEKARKDRERQERRIEKDLKERWLESKKAELKSEETRLRTAKEDVDAADLRDDEKLRAIQAKIRAREDREWRERLMAEKEKFAHIRRQQEEQRKKQEQEAAEAVRKQNLERREAQRQYEEANRRRQKIVDDEAARRRERYMHFEYMGGDTRTTSTSNCRHGGWWPKIQGSTACPRCYEWWTYLLQCPGCGIKACPRCQASIRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJS8</accession>
    <name>A0A1C1CJS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJS8"/>
    <dbReference type="STRING" id="86049.A0A1C1CJS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05151"/>
    <dbReference type="OrthoDB" id="2015405at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="13"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="223" mass="23600" checksum="88F92CF1E254CD77" modified="2016-11-02" version="1">MATSLSDGVRKIMRHVPHPVAVITSTDTSVSPEGAPTAWRGATVSSFNTVTLRPKPIVSFNITKHSSTYSAIKSSGLFNVHLLNCSSSSSSIAGRFSRGNASSPFHDEDGSLAAWAEEQHMNAPAPSHLGPQIGRKSPVIKTPLQAVLRCTHISHKAVEIGDHVVILGEVVEKHDELHHLEEASVWLYYVNGKYSPLISTKSSGNVSVGPGLLAPKGQGAAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK09</accession>
    <name>A0A1C1CK09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear cap-binding protein subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK09"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04794"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03046"/>
    <dbReference type="eggNOG" id="ENOG502S34X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="56531" checksum="FA535ED79099888A" modified="2016-11-02" version="1">MALAMASAVSSGQDADLMDIDIDMDMDDQGPILDDEFQLEEGEEPSFVPSGTAPSVTNPSTLIPAIYTEDPALEPQWNKVHIRGVDDLHTNDILAFVHDHFSEAGDDIHVQWVDDTSANIVFKADDAAKQAHVAFLANPVSVEELTNNPFELRAAKHLTSRPASTLLVRVAQQGDRKKKGAREASRYYLMHPDQDPTERMRKEFENTRGDYRRRRFDDRELYRRRGGGGRGYQDAGNGGDPTDSFSSDMYDDAPATDPENTDKARGRDMFSRVAKGRRRSASPGMRTRNSDEIEISESDDDGRARRRNYRDRAPPRANNAGKELFSSTSSPKSGGGLRSDRLDLFPAKPSDTDTSMSTDPVSPLRPIDAANNRANAAAAKRLKADLLSASQTSPRSNHRRSHAMDAKNEEDLAERFARKSISIDSTKSRNGASNAGVELFPSNGGGGGMSIKGASDGLSIKGSGGLSIKGRALEVKELFPNQYQKTGTGRNEGKELFDAPVREKRVRRRAGDLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKK6</accession>
    <name>A0A1C1CKK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05185"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02910"/>
    <dbReference type="eggNOG" id="ENOG502QW79">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="112749at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34204">
        <property type="entry name" value="RNA-BINDING ASCH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34204:SF2">
        <property type="entry name" value="RNA-BINDING ASCH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="195" mass="21854" checksum="A9E79CED990F41AF" modified="2016-11-02" version="1">MYSTLLLPWSADPPGREQAYRAAGLVRTKGTLFLLPPPDSVLRETFNAPPRPKTRMSSGAVALCKHFERGGASSEHGRAHPFWTLPQGSNDNKTEIARQILEQMLAEAVWKNVMLLHHGVAVYEIRNAKGFGMRWTLDIKEKKCPDGVDSTATMCDAQDDEDQDDFEEDWEVTRTTFRGFLEPIAGMDHELDGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKT5</accession>
    <name>A0A1C1CKT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05284"/>
    <dbReference type="OrthoDB" id="10457782at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="102" mass="11444" checksum="60162E931921C1D5" modified="2016-11-02" version="1">MSTTLSIELTLSKRSPWKGLSPHSMIIPSVETNKQPAQPSRLPLVGYPNPRIFQPGEENESRYTLEIEYVVKDHAGQHTMTMEAGRDKPILHVVYGWADAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKV4</accession>
    <name>A0A1C1CKV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2 type zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_04598</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKV4"/>
    <dbReference type="STRING" id="86049.A0A1C1CKV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04598"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02785"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF14">
        <property type="entry name" value="C2H2 TYPE ZINC FINGER DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT49140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="705" mass="78145" checksum="DD928BF3F5C0C26B" modified="2016-11-02" version="1">MSSTRRGRIHVCPRCGKTYGKREHLIRHERSHTGSRPYVCDACGTQFTRLDSLSRHSRRHTGASVDNQSPGQDLRTENGRAQSQSRARTSPDDVSSPMRNCDAPNSTYQVVADGMQLDHEPFGSLNWPDSEDLLNSILSAEFTTLPALEVLPSQSIVCGATDLESHPVASWLAFDSNQDNLHGGNHAVQSLSHIINSTSGDVTSTAQSLGLTSVFLDGCLHMFFTQFVPNFPVVHRPTFVFRDWTSPLLLNAIALGSLFMGKKDCVAKVRDVAFGEALWRLAHTAVATSNIKLRKTAQVFHSLGFFWARECGMFDLQADKDSEAPALDPSTTEDAVEEEWRVWAARETQLRALLGEHVLEKSVLVETILTVGICLLITLTQLKGHYVLDAQLSDYTSAPSQRHTSHCLPAPANDAMFSAQDAATWRTEMLNQKNDPGPLFQMFCSLFSENVHGRHLGTSLSSFTASVLLEGLKALSAERIASPPGVIGMPSELDISRALGKLHTFVVQSRSLSSVEKEVALLRWHTVGLHMAVDLNFLCRALFQRYNINQHVIGARGVPPLDLSSWVCTGKARLGLLHAFSIYGILQNLPFVQTQKIHIPMAVFSAAMMYSAFLLGGVSTISLPDIEGWESVVPIDLDTSLNSEKPELDHEVRQYLSGRLQKHGRCINLLYDVNLFSRTLKTLEELWGVSYEMHRVLEELSLRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL87</accession>
    <name>A0A1C1CL87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL87"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04793"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02723"/>
    <dbReference type="OrthoDB" id="4158657at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="294"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="535" mass="59312" checksum="FF38DD4E55579F37" modified="2016-11-02" version="1">MGASQSVQNAPGISREDVQREMELIHRRLETVSIPDQATEYADILPHYHHVLSMIDLESVQQSIAVFHLMISSHAKATRLSTTYASLTAELVQCQQMLITLYAGIRSSKSALLQFGSPMSVDSTKDSKIKELADTITFMVDELDGVQGHLFHILHVMLQASQTCAGGHVPQQDIAKSCPAELRDALQALEETHLALRNRISKVMSDYAKAVERTHELSKDKKHLNEVAEQLAASLKSADGENQALQAQNAKLIEECREKNMWIRGINVKIDGMCDTMKRAEAIVLGQKAAGCEQKKDQEEVKQLRAENARLDDQEQVKQLRAENARLKDQSTKVEALRAENSGLKRKLKESNVKDLEKRLHEANTELDQLRKTLFKDRDDDDDDGRPQNDHAHPDAVSSSSDDEEPSNAVEGLSFAEGAARILQCHKAVLAELRAQISKMKDVRGGSGWSIVHRTDAMVKRKTARLLKDIDDCLALRDAGEREKDRVERLETEGFPALQAVISGACQSTKDSGAAKATKSKGIRTRGKSSFPGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLM9</accession>
    <name>A0A1C1CLM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_04563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLM9"/>
    <dbReference type="STRING" id="86049.A0A1C1CLM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04563"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03314"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF6">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25788">
        <property type="entry name" value="Ig_Rha78A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial alpha-L-rhamnosidase N-terminal" evidence="5">
        <location>
            <begin position="156"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase concanavalin-like" evidence="4">
        <location>
            <begin position="340"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="6">
        <location>
            <begin position="452"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="7">
        <location>
            <begin position="815"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="935" mass="103782" checksum="0601ECB0F3555D01" modified="2016-11-02" version="1">MALASRPFAVTDVRFEHYLPEYALGVHELQPRVSWRFQNAPEGFQQQGYELELVDIPSSSQETRNLGTFKVESSASALVPWPHQDRLQSRQRVGVRVRVWDGTGCNSEWSEQSVLEVGLLNRQDWKCQRITTSWPTDPSRPGPEHLFRKQFSTRAEVAHARLYITAQGLYEANINGTRVGDQLLTPGWTDYSKRLQYQTYDVTQLVSPGPHENCIGVRLAEGWFCGRIGFEGGRRNIWGSQMTLLAQLEIQYADGVQEVICTDDTWQTTLGPTRLAEIYDGEKYDANLEIPGWSTGGGANSGVWRNATALENLPETTKLIAGTGEPVRAVEVLKPVRHIQTPSGKSILDFGQNCTGYTRIKKVRGVRGQTITLFHAEVLEHGELGRRPLRQADACDQYTFSGATEGESWEPRFTFHGFRYVQVDGWPASEEAGNSMMDSFEVVVCHSAMEPVGTFSCSDPRLEKLHTNVKWSMRSNFVSIPTDCPQRDERLGWTGDLALFAPAATLLYNCYGLVANWLVDVRGDQDDLDGIPPVVSPNVVKEDFVWGEVTPFAIWHDCTILGPWALYQATGDSTILATSYESMTTWLDRIPRNKTRGTILWDPNLFQLGDWLDPSASPHNAAGGQTDSILVADAFLIHSLETMANVCAILEAGSTQADAYRAAAERYRSETQQAKSAFQNEYISPSGRVVSDSQAAYALAIVFDLFETRAQKMRAGERLAEIVRRNDFKVGTGFAGTPFVCEALALANQTPVAYGMLLNEQCPSWLYPVTMGATTVWERWDSMLPDGTINPGSMTSFNHYAFGAVITFFYERIVGLKRLEPGWKRASFTPAPGGGLTHSQASVLTPYGELSCTWSLDRKGGEQVDGEQPTALQVAVVVPANVVVELVLPSTAADLERKQSIQELSSGTWSFCVPWVGSSDAEWPVKPIHVNPFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLQ0</accession>
    <name>A0A1C1CLQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ethylene receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_04502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLQ0"/>
    <dbReference type="STRING" id="86049.A0A1C1CLQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04502"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03301"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000050">
        <property type="entry name" value="Related to histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000099">
        <property type="entry name" value="Sensory box sensor histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="65"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="462"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="742"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="1047"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="987"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1231"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1272"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1366"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1418"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="998"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1011"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1028"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1282"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1368"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1424"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1436"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1471" mass="161240" checksum="25ACD06228590829" modified="2016-11-02" version="1">MVVGDAEAAHRPLNANGIVRPVRPAQPRTSSLPISHGGRQHVKPPPVDGDHAHAHTPAPPLPVAAEVALAALVTLPTPILVLSSSKTVLLANAAVSRLLGIDEEDVDGGATDTLRGQTLSQLGIDMVSDGVPIWVSWERFLDNVADSHDRVAAGQPLLGARGGETSPIAMGDGDAERGRLPFRTGAHKSHDAVVDVVISHRHDQVPPRLRRRRQNKPGSRIQATCRMIISLWNLEDQRFFTLTFTSSAGPSSDHASSPSSLRNVSSHSTRSSQSSQGQTPLSSTTDPDVTSPAPLEPAGGLPFPSIAPPPKCTAPSTLTDFQKVLKMKNAMLRAVDIPLVAMWRDESVVFPNTAARKLLEVNTDPVSEHSYDFMSRLRPWTPDFSRELDETANPIVALCRDQQAFTNWQVGLLNEKTGKRSNFEVSGHPVYDERSGDFLAGMVAFKDVTEYTEQLAHQTAENEEQFRLICDMMPQMIFTTTPEGLVTYWSQRWYDYTGLSATDSLGLGWQLPFHVEDMPHTTRRWQHALATGEEYTTEYRCKRVDGQWRWMLGRALPMRDHKTGNILKWFGTCTDIQDIVDAKVSGQRARQQLLDVLKHSQMTMWIIDRERTVTFYEGDFIMGDPVHDRIIGSQVLDVVGDYLAPQDIVKFEEALARLMSGLSDLEILENEANARWFRSTMVPMKGKTGPKGVEDENYIAGVIVIVSDVTGLRRKEQENIKLLANEAAAKEASKMKSSFLANMSHEIRTPIAGVLGMSELLMDTNLDAEQSEFAQNIQRSANSLLTVINDILDFSKIESGRLDIEEVQFSLAVVLRDVAKMLSFAAQRKGLQFSSDIQLGPSEDLILLGDPGRIRQILVNLLTNSIKFTSEGYVRLRADILTQTSDMVTVEFCVEDSGIGIEEEVKKRLFRPFSQADSSTARRFGGTGLGLTISKNLVDLMHGTIRLESKLDAGTRATFTIPLKMPEYPVGSPTAFLEVGSMPDRLQSDLSMSIPDSPRPESRRFERGASPLQSAADTNANDIRHVGVSSQPATQSMEPELPRDQIHVLVVEDNPVNQQIALRFIQALKFSVKAVWNGKEALEYLLKATSPDLSPEQAKEYPIPSLILMDVQMPVLDGYHTTHMLRHHAPFKDIQAIPHIPIVAMTASAIQGDREKCEKAGMDDYMAKPVKRSLLEKTILKWVSRGRTVQERQKLSVYGTDSKKPNLGRACTDHSSICAQNDAIASEFRARNGSHDTQADADEPNAPLPLGESEDVAGRAVARRSGISRALLESEIPGGETEADRAARRAAAEDQARALRDAKLLSATDMAHGNSHIAPVLRVDNDYAPDLQAPDRQASESTAGASLMALTEENVLLLNAAQDGVIPTTGTSSPGPESQGYTYPLSDIPGPPPEGTLSAIDLAHIDADAEALVSSILEKTRVPGSSTGSRTTSDSLEQKAPRNRRDVGGLGPESRHVSDWSSSTARPEKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMH7</accession>
    <name>A0A1C1CMH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07534"/>
    <dbReference type="OrthoDB" id="10616586at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="240" mass="26474" checksum="D48C3E66F8A64B71" modified="2016-11-02" version="1">MSKRTPVLQGASESGYKDGRSNTTPQNRQQRDGRDQANLQHQQDQRRSEQGDRPFGQGSRRRGVEQEQYLNTAEAGQQQRRHPAPSDPYTPHGDSLAGSRSQREPAHNIDRRGGISWQERGPSEGQQDAAHNTASIPPRNRPRNMDSYADRSRQQQGFESRDHGSEEKHHGCSDVHSGATSNSSSGGSSVSNNGTGSKNKKPGRLKRAGRAIVGFARAGNWRRKDEDDDTHGSSTGTWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN14</accession>
    <name>A0A1C1CN14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BZIP family transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN14"/>
    <dbReference type="STRING" id="86049.A0A1C1CN14"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06741"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08755"/>
    <dbReference type="eggNOG" id="ENOG502S6P7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="725" mass="79915" checksum="01250A639A4D10F6" modified="2016-11-02" version="1">MSVVMPMHAFTKPRYGDRRYSSLESILDNPTHLLMSSQAVERPIGGDLDILSASRYPQGLMQPYEEMEAQNPRKRKATSSMDQLYGGIVLAGSAASESNRSSSAEHDTPSTQKKAKSTKRASTNEGDEQAMEKKQRGRPRLDTHDETPADRRRTQIRLAQRAYRHRKETTISALKQKVTDLQNTIEQMNKTFLTLHDNMVDTGILASHYALGRQLQSATEAFVALAKIASPESDDEEEAAIVALTQGEGKATPEAGEKSNNRRGSGSKDAKLSSSTTKPSAKKTNVHRGVSLNDHGSPDAEADVEDLPAASQPVGTFLAPSQTAWTLDSSNIHGLNEVLSFDANATIPDAILYDDPNERLVLERPLNPPNQPQGSPYTYSFQETTFARRLHRMCVERAFRKLTSPSIDPAYIKRVFRFTFCFSNRRRMLQRFQEVLKRRAGESLENWNAPFFHIGGAGTHFPRRDDGGNPIYPPNMVSPARAFGPQPYVEAETPRLEASMQEMLDNIGFGGIWFDSHDVEEYLKTKGLYLTGQSSFVEVDPAVLSLVKSTTSTTTTTTNSDADASTSDHSPLENALRTPSPLPPAEHLTDPFIGPDLSELWGPLLQSAATVTTTAPATARVFIPAATRAQTPKSINGDDDADNIWTNFPFPFSSHPGTSTPVTFSDNLLGSSRRRNRRQIRPPLTFDVEMFLERMIEGSACLGRAPGFRKAAIDQALVASLQEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN59</accession>
    <name>A0A1C1CN59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CLCR_06656</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN59"/>
    <dbReference type="STRING" id="86049.A0A1C1CN59"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06656"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08801"/>
    <dbReference type="eggNOG" id="KOG0338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="318"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="684"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="563"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="641"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT49881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="878" mass="95767" checksum="B511A62094CE2A6A" modified="2016-11-02" version="1">MSRFYARYVPPAKALSTEAVASTEPSSSPNKRKRDEQVSQPKDKKLKTSKSAAQPHTTPSNQPHPHNIPPSETSSAASGTVILDKYRVTETARSGGAPIRVRSHRSEGPSQPGEPELGVEYGQGGNEGERKIKSVSEKTLRGEAGEAQDETKAATSIPRAVDSERSGAVQRKDEGVSKRTKKGERPKRSHAAEEAEGTEDAEDAAHAQKHAAVLSKFEKAKQQDQLHTKSEPPPEQTAPELHGLEPIPQPEQVEVVREVPTYSILPAWQENPLIVPSETKKEHFSSFELAEVLVGNLRRKGLHHPLPIQAAVLPLLLNGPGKHAGDLCISAATGSGKTLSYVLPIIAALKDLPGRKLRAVIVVPTRELVKQVRDLCEACAAGTSLKFATAVGSKSLNDEQQMLVKEEKIYDPEEYEKWQQSPIDWSNFSLARLAQRAKDEDPLESVGYITRYRSKIDVLITTPGRLVDHLRSTPGFTLDHLSWLVVDEADRLLNESYQEWVGVVKPALESQAATERRDWLLRHMRMTPPKRRVSKILLSATMTRDLSKLNALGLHNPKLVVLGGNKPGKKGDEAGSPAPDTQDAVLPQKDDKNTFHLPETLKEVAIPLPDGSEKPLFLLELVRNHIGITVPLSKAATNISNALVDTGPRPDSTTKSSSQSEDLPSDEASSSADSGSGSERTPAPLKDVTSTGTERKQSDQPPRALIFARSTASAERLARLICLLDPELATQVSTLTRSTASSASSRRALASFRNSRISILIATDRASRGLDVPGLEHVVSYDVPNSVLTYVHRVGRTARAGKGGQAWSLVEHREAAWFWREIGGKGKQLAPAKALPEPSIHRKGKLSKLQLSLEHLDLKPKYEDALRKLGEEVLAKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNV2</accession>
    <name>A0A1C1CNV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07573"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05803"/>
    <dbReference type="OrthoDB" id="4113403at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="210" mass="22845" checksum="B551DF39A2E02C3D" modified="2016-11-02" version="1">MCSSSKPTEPWDLETRVRLLLLLNNAVALALSFARMEVLFIVVGSILGVSIIFNMLVLLSKVRPHRLALTNDDVHRQSPSLLVWVTDGVGVLAFLALYVCSTIETASRDSLWNGVPVLLMTYASIGTLVACAMHGYMALKSLQKYIRYRQSLTSSCPHCHQELGFVAASIALPPSPISRINQAESSPAPRESFSANSAGENEGDMLILKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP02</accession>
    <name>A0A1C1CP02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP02"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07768"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="119" mass="12936" checksum="3BFC2D191C0B8252" modified="2016-11-02" version="1">MSSPTSAQAPASRCDPDPTRQEVAKAGRLVEFVKSKHTASRSPSLCVSPWFATADTEGENGHGILFREAMVRRSSELKSEMDSLASISPSVPGDYIIVRGDVVRPLGKEKISVILWYCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPM2</accession>
    <name>A0A1C1CPM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPM2"/>
    <dbReference type="STRING" id="86049.A0A1C1CPM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07343"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05580"/>
    <dbReference type="eggNOG" id="KOG1844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="345" mass="36524" checksum="07EF791C8183B3F9" modified="2016-11-02" version="1">MTSHKGNSKRRRTGSNSSDTLSKHSESPEPVAIDEGSQALSTAAQKLRGAAARNTREKELREKQKEQQAAQRAEAASKRNARSERRRGEDSPPPTPSLSPAKAVQSNGRPKAETPPSGRSNLNGRKTGGRAPVRRARLGRNQNARDRENGDEESTPHHDASHELNGGDKSGGASPPANGAEGKDHTKSATGHGHNINGESGRSSKAKTHPARTSMNEMKRRVAAILEFVGRMQTERTTQLAAQNTANGHGSDGSSKGTNTPNGLSKSSSGSRLSAAGASALPTASLVRAVEAGLKDVQGQGGDGGENAMLMMDDREFGTMGSVDMMESLTKKLVQWQSMYGVYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPQ8</accession>
    <name>A0A1C1CPQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">tRNA-splicing endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_06526</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPQ8"/>
    <dbReference type="STRING" id="86049.A0A1C1CPQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06526"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05518"/>
    <dbReference type="eggNOG" id="KOG1801">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001152">
        <property type="entry name" value="tRNA-splicing endonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056474">
        <property type="entry name" value="SEN1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23576">
        <property type="entry name" value="SEN1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="2021"/>
            <end position="2035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="886"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1022"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1047"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1841"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2045"/>
            <end position="2188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="886"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1032"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1844"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1883"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1901"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1914"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1953"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2047"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2178"/>
            <end position="2188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT50490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="2188" mass="244626" checksum="CCA026C6CA8A135B" modified="2016-11-02" version="1">MAEFITILEEFKSLPPEQHIFCPRDNDDDTDRYEDERDPSGNATATVDPSRPAKIEEAKKRRKGFVSALQLLAYDGKESEQYQSYIWARLDEALGKCDVCIREYYIAKIDLREQLRQEYEDSDIANFFSLINRRDVARIVRGLDAADETLRDTPEQKRGTSSLDKRHLHALFEALVCQAFLEDEDKLKNHFDGPFKMVQTRKPLKMREILPAAAQFLFSSETIRTYWASLIWKRLEKPPSELEWDWAVKDYLQKKLQHVSNDSDVMRLWSALDLIVSKLDAHMITHKLFDLNPNLATTALNHLAKKTSAVPYILATLKQILEKAPEAFWDKMGSISSQTIIEQIFASPSYNKFLQDSTAASDGSGQDVLSWISSLLDSLKPANRPFAAQTLLHQLFERIENSSISLLARRACFEQAVKVLRKTLTSFSGDEEDPQHAVERLVYIDTLNLVGHRLDTILKPRDTGLAQARQQETRNEIVDVVRNAVALECKCLKLDFENLSRSEPRRQDSSAYTPEIWNAVINNLREDDQKLSTAALLGIMSLPGLEQFRIRQGDKVAKEKQSYNSIFEKLNAMVGRILERISGFNSPHLDALFKQQETAMSLVAALFSPDQGIYEAAITMIKNISGEFGRKEALSHLIASFTGTTIYGICWLFRRVANYKTFASVPRMLKTGMEILDVLCNPTDGHLRRMPLSPRDVLAVQRYWSYQWVALKTIYGYTERWSIEVHSKETMKEVCRDAMQYAEELFNQYDLFASIVENSKPEKAEEVRKTLLDSSCSNEKNMGSPLSTLDTMCKWLRLRDDYLADTLVTLICNMLGQLKRHSAVNNNSEGLTYVEEVATGTSIRTMLSASQKARLVRALENYFDRQIEKPVKKQATLNLDRWTDSAAASGSTTPVSREHSVEDFGDDGIDDDDLVEITNKTLGTSKTTITAHDKNNIKSLLSKKPPVKPKPTPMSMVEIQARKAQEAKSFIENRKREEAARKLRDKEAAARLRGKTGIGVQTAGQGSGLAGLGVVGKDHSAGPNSLMVSSESEAESDSEDELFGIKSKGPAIPGQAVPRRPLAAGPVRKIKQQRTHKDIRARLMPDLSELHRTMLGWDFFADTDTPPNSTTDDYTLVTDTFRTPQDYQKTFEPLLVLEAWQSFRSAREEREEGNSRAFEVKVANSLIVDSFFEINSLMSFAEGKDLGIGVSDVVLLSKSSKPIQEPREPHCLARVKEITRKRGEVQVVYRVNAANNPLRPYLNDKAVVYGVQIQSLTPLEREYGALMALQYYDLCDEIIRAKPSPILDYADEVLRPIKKTYNVNLAQAKAVKSALDNDAFTLIQGPPGSGKTKTICALVGAMLTGFVKKQSTGPKLNTTQGAPRPPPASKKLLVCAPSNAAVDELVMRFKAGVTMLDGSFERVSVVRLGRSEAINNNVKDVTLEELVNAKLASAGPKAPGEDIHLLMMEHKQVSEELRNLRDSVSERRGTGETSLLKEEQLMDALIRKQRGLGGKIDDMREKQNTASRDMDLTRKRVQQEILDGAHVLCATLSGSGHELFQGLNVEFETVIIDEAAQSIELSALIPLKYGCSKCILVGDPKQLPPTVLSRKAAKFQYEQSLFARMENNHKKDVHLLDTQYRMHPEISLFPSKTFYDSRLKDGEGMAKLRRRPWHHSDLFAPYRFFDVQGMSQAATKGHSLVNPAEILVAMQIYKRLTTDVRKYDFAGKIGIITPYKGQLRELKRRFQNEYGEGIFSKIEFNTTDAFQGRESEIIIFSCVRASTQGIGFLNDIRRMNVGLTRAKCSLWVLGNSQALMQGEFWRALVTDAKDRHLYTDGDIAKLFNRQLLTDDMMKDDIEMMDPSESVSETVKGSTHSEEPFTATAASKDPSPTSVKGARDVTRSAGTPNQDTPLPSRPGSALSRQSSTASIANSETRRHDSVQSTTRRESGREESSPVQHPPPRRPQLEPRTQSASTAADTSDYSPSGGANGLNDLRNCAICGSYQHVSAACDNEAALADQYGKCRRCQGTGHTLTNCIDPRCLSCGEVGHTTDRCTAPLGQRLSKAQQEKVRQEEVRYGSIRDKARQRRADKEHEAHTIPTIKSTVPSLDRADGNKRKRDASSSSSDRAKVPRPNQESRPPGSELTSGDRRPASTPTGPQGRPGPGQPPPGSSALPPRHPGRPGMPNGGAPMVRKKKVNAEDMFVKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ01</accession>
    <name>A0A1C1CQ01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">med6</name>
        <name evidence="8" type="synonym">MED6</name>
        <name evidence="10" type="ORF">CLCR_07324</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ01"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ01"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07324"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05448"/>
    <dbReference type="eggNOG" id="KOG3169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="180"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="256"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT50565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="338" mass="36540" checksum="6E7514A94BF1F9E3" modified="2016-11-02" version="1">MAENKDDLSDKAHFDPNWISYNGGYLHSNNVLFYFATSPFFDQVSGNQSLITQWVGTPNQNEILGTRARFEANLRHQRGIQYVVEHDPLEEKATIQGPNGPENTNVWVIRKQNRQNERDDSVTVLGYYYIVNNVIYQAPTVASILNNRLLNTVSALNKLFIAPTDMSLFSVSHGHTYYKPVKPSTRQGPAGAVGPQSREGSVVPESGAPTAEKVAVASQAHEESGSGARTAWEALRMTIAYGKEYSDDMPLVGEPGNFRFSKNKDTAATAGQTKPQNQASSSPIGTPGHSRAGSVAAPPPSNAAAAPRLVRTGDKATPTSEGTAKIKRKKSKVEGGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ23</accession>
    <name>A0A1C1CQ23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF803 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_06925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ23"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ23"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06925"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05425"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="359"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="451"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT50588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="580" mass="63978" checksum="7F82D756FD31DA8E" modified="2016-11-02" version="1">MGQLGDISPQGTIAIGVIVGLLSTSVQSLGLTLQRQSHIIEDDKPHTEPRTPPYKRRRWQLGMLMFLVSNVVGSTIQITTLPLPVLSTLQASGLVFNTAFATLLLGEPFTRFSLIGTLLTCSGAALIAAFGAIGEPAHNLRQLLHLLGQRDFIMWMVATMLVVTATILFAHVLKMWSSHKRIAESLAKTERPRSRAGSISTDRQRTLSRSFTAQLPHPLRIRVNRLRLTRGLSYALISGILSAHSLLVAKSAVELVVRTIVDHKNQFDRFQSWLILVALLFFALTQLYYLHLGLRLCSTSVLYPFVFCIYNIIAILDGLIYFQQGSRLSSRDAGLVALGTAILLTGVLALSWRLDDTTPEEAAHQSPAPPQTPLTPGMGILRSPVDERAPLLPTRKRRNSSAASQDSNDQERPVRVSRTRAMPSTLPVHAPRDPDTEGIWAELDDEDRHGDYLASLPRTPSPFLTQNFKRRRRGDSSLSQAVSTGSRRSSDGTGKTGQKNESESTEEPRGAHLRRSGTPQETAVAKATDETDGARPRTRHRSTSVRFADQPASLEEQPQPQPLRSRYDYDGTTENVSQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ47</accession>
    <name>A0A1C1CQ47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit CNL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CNO-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_07623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLOC1S4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ47"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ47"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07623"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05387"/>
    <dbReference type="eggNOG" id="ENOG502S5Q7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5424991at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046465">
        <property type="entry name" value="BORCS6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034455">
        <property type="entry name" value="CNL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10157">
        <property type="entry name" value="BORCS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BLOC-1-related complex subunit 6 C-terminal helix" evidence="8">
        <location>
            <begin position="78"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="181" mass="20123" checksum="D609EDF6067DD6E3" modified="2016-11-02" version="1">MSAPQSVAGSALGVFTQAELLTLQHQQQIMAQRSHQGGVPADRGRGTSRQSQPSSRAVSAASSQSMPGRVMLDPHSLQALHTHLENVMRTIQRRIEELEDATEQSVRNSSGRAANSIQNADHEIARMRRIMQDIDTLEEEFQKIKRIRDKIKAIRNNVDQLSEKLDRSRPSGHGSGGARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQH9</accession>
    <name>A0A1C1CQH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium influx-promoting protein ehs1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ehs1</name>
        <name evidence="2" type="ORF">CLCR_06884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQH9"/>
    <dbReference type="STRING" id="86049.A0A1C1CQH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06884"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05288"/>
    <dbReference type="eggNOG" id="ENOG502QTA4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5405745at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142:SF1">
        <property type="entry name" value="AEL197CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142">
        <property type="entry name" value="MID1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="619" mass="66726" checksum="8F15CD7572216525" modified="2016-11-02" version="1">MPLVPKLGQLSPLQLRFGACLSASLFLLLLYLTLTKPHFAYAHELNPEDHNYAFNLDSEALDAPERTNPIVPRAEDGVSALANNGPQNSNIGIGLTQNWVFPKDVIDGPHGDLGTGLPGEKAEATQLEPEVHELRRRQSGTTVYITINTCLQPSSNVTDAIPPQLEMYISLSPSNQKPGPGSGTPVSVIGGYGLYEVDATDDVYVGITAPNTTAFSGIWNYEIAASIDTPYHFFNSSKTPNLYFVDSDNHAALLITNDTTQALPNETVYQEWMKMDPPYGVFASNQDQRSILGIQRSFCGLRNNAKLAAKINDVTNQNVATMTNRGIGGKPKEQFYITGLNATSRYWGMLVMEGNSTASGAGVVGGGGTVWAAIDFNTKTEGNCALMYNLSFCSEVAYAVPTNPNKFSPETGLPDLAALYDSNAAQMYQYFNYSLQQIPCNTTSSAQYSLARNCDDCARAYKQWLCAVTIPRCADYSNPSGYLKPRNVGQPFINGSSISSDPSLDPGQDQALLAAVATNSSRNPLIDTSIAPGPYKEVLPCEDLCYGLVQSCPASLGFACPIAGKGLEESYGKRVNESEGIISCSYLGAAYYLSASSMLTPGLNIYWVALLVLMFAIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQV5</accession>
    <name>A0A1C1CQV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cdc4</name>
        <name evidence="4" type="ORF">CLCR_09209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQV5"/>
    <dbReference type="STRING" id="86049.A0A1C1CQV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09209"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09507"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071341">
        <property type="term" value="C:medial cortical node"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="148" mass="16362" checksum="FDC791F0E3D19E34" modified="2016-11-02" version="1">MANASSSAGQTSTNYKEAFSLYDKRGNGRVALESLGDLLRACGQNPTLAEIRDLEKQVGGDFDFDSFQKVLNRPGGFRDPGEPEEYCRGFQVFDKDMTGFIGVGQLRYILTNLGEKMSDEEVDELLKAVDTSSGEINYMELVRTILAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQY6</accession>
    <name>A0A1C1CQY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_08382</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08382"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09535"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000934">
        <property type="entry name" value="Allantoate permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF70">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="64"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="515" mass="56956" checksum="4FBFA3BB02E7CBF3" modified="2016-11-02" version="1">MAANEASIEADKINAVHGSPVSGASTPYRSSDLDDDYHLYKRSDDQELDIIESKRVLRKLDFRIVPILFLIYLMQYLDKNGINYASVYGLQDGTNLHGQDYSWLGSIFYFGYLWAQYPAGYVLQRLRVGKVIGITTISWGIILVTTPACSSFAGIAVNRFLLGSFEAVVNPGFILIMSIWYTTSEQPLRLEAYYCTNGVATMFGGLIGYAVGHITTGLPRWMYVFIIFGSISIALGILALIFLPDQPSTAKFLTDAEKVIAAKRVSANRQGIKNRHFKRYQVIQTIQDPKTWILFVMAVGAQVPNSAITQFTSLVIKSFNVDTLGTQYLQIPGGAIQFLALLGGGIICSRWPNLRCPTMIVANTICIIGASLLVGLPDSNKWGRLVGLWLCFFQGLGFSMSLTMVSSNIAGYTKKQLTAAILFTGYCVGNIIGPQTFKSSDAPAYHSAYVAMLVGYIIKLVSIIVLYIYMYLVNKKRDREAAASGVVDLDEEKEAIERGMHDVTELDNKGFRYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQZ4</accession>
    <name>A0A1C1CQZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09241"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01762"/>
    <dbReference type="OrthoDB" id="5430620at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="143" mass="15931" checksum="2740656F259D8ABB" modified="2016-11-02" version="1">MRYLQTFQLSYANTSAYVGRIISRSYAEPLIVGGFNNDDDNNSISFLSTHQSPAGVQQKYIVPHESQAVDFSVPHGSTPEGESTTGILVRPQWRVVAWCINRFYACRNDALAPLNSYQIYWNAAGQPLGWMCQGPVLIQADDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRQ2</accession>
    <name>A0A1C1CRQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09302"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="74" mass="8432" checksum="765AB971B8BA4098" modified="2016-11-02" version="1">MPASIIQPDEDLDQPRKFMLFGLEIFHQLQCPNLLGKRIYGVNILDITGEHSLEIQIKSLLGLSPPRFSRVMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS47</accession>
    <name>A0A1C1CS47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aryl-alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xylB</name>
        <name evidence="8" type="ORF">CLCR_08735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS47"/>
    <dbReference type="STRING" id="86049.A0A1C1CS47"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08735"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06761"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08278">
        <property type="entry name" value="benzyl_alcohol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF11">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="15"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="378" mass="39748" checksum="CFB320F4C767961B" modified="2016-11-02" version="1">MAGTLTTTEALVLLALKAPLQLQRIHLSPLQEDEVLVEIHATGICHTDLSCMDGMLPISTPAVLGHEGAGVVLAVGTDVSHVSKGDKVLLSINVCQKCPNCLAGHPNYCDQGMPRNFGGCRVSDGSTTMSIDTDTEDGTVPCFSSFFGQSSFSRHAVVDQSCVLKVPHDTDLKLFAPLGCGISTGVGSVVNTLDLKDGSSLAVFGVGSVGLSAVMAGKLRNAGTIIAIDLNPHRLEVARKLGATHVVHGNSADVVAEVKTHAPSGVNYAVDCTGAARVIETMMECLAVRGRAAQVGLTAPDRTVPIKILQHLLRGQEYVGCAGGDCIPGEMLPYLMDQQQAGNFPLEEIVSYYDAKDHARAFEDSRSGKAIKAVLCWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS61</accession>
    <name>A0A1C1CS61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nuclease S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nucS</name>
        <name evidence="9" type="ORF">CLCR_08926</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS61"/>
    <dbReference type="STRING" id="86049.A0A1C1CS61"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08926"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06754"/>
    <dbReference type="eggNOG" id="ENOG502QRXU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651005" evidence="8">
        <location>
            <begin position="22"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT51330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="297" mass="33065" checksum="A65383BE3553F430" modified="2016-11-02" version="1">MHHPLLVLLVPLALLLPSTFAWGTLGHRTVAYLASLYFTPESTRFTNQLLHGQDISEAALFPDKIRYIPSFAYTKAWHYIDAQDDPPTRCGINITRDCALETGCVVSAIANHTERVGDAGLPMWQRGQSLRFVLHFFGDVHQPLHTEAEDRGGNEYAVVFDGRATNLHSVWDSLIVNRHAGMGHEDETLAAWTWAQRLAAGRDAEDDEDVCLRDAAECALEWAGEANAYVCSYVLARDVHGQDLAGEYYDGAVPIIDDMVYKAGRRLAAWINAIVGDMDYADLDLLDPEPLLRTQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSD8</accession>
    <name>A0A1C1CSD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cutinase transcription factor 1 beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSD8"/>
    <dbReference type="STRING" id="86049.A0A1C1CSD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08006"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06695"/>
    <dbReference type="eggNOG" id="ENOG502RHAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4451586at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="346"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="850" mass="95609" checksum="D05FA7F1861FBBEA" modified="2016-11-02" version="1">MATMTPPTTTQTSPKRKSSAAGLSAGATPLRWPWWRLTAVRSDVVESGIPCTNCRLDEVECVVTEGKRRRKTYSEGELFHQSPCNSAEEEKELPQFPIFDDIDELNNFLPSLPSCETTRSLKGAEDMFQHKPHMLCKYSRWTALRTMPTHLPLDQTQGHRLSQEERFRRMSVISSKQQSPSLPLTTTMSYFPPQPSRPNIVLPPFIRPISPRIMTEDLEFLQRKGALLIPETGFRNELLRCYVQYVYPFMPIIDLQDFLGTIEKNQATDTVSLLLFQAVMFAATAYIDMRYLLAQGYMTRKAARKSFFEKVKLLYDFDYEADRITIVQAALLMTYWYESPDDPKDVWHWLGIATSVARTIGLNCDTSNAPLMTPQQRRLWKRIWWSCYMRDRLIAIGMRRPMRINDGDFDVQMLDVSDFETESLSPELSKMLGGCPAVKDSSKRVTLAKMCIGLAQLCLCISKVLAVQYSTLGHKIGATQETTMRLVPKKSAAEPADVIQCDREFEQWHQSLDPGIPYFAPDSRERVATNDGEVVHLHRALLNGVYLTAISALHRPQILPSAPNVVVVPELRELSKRKVREAADDITEMYKELFALDMIRYLPNTGVTCLLPAIIIHLLDIKSTDNNIRQASTRKFHFCMQALQRLREMYASADFAFSFLDAAVRKTNAQVSAVAAAAPTMKESLSHPPLEQKLGQAPLLLTPPPEAMQTASLLLMNSTLAPEERSLIAAYTPRTPAGSDVSLSSHTTAGAAAALTDLPEEHSTEIKDELEQMDEADFDTLMDLESGTDLFAMAEDDMDLSMQWLQGFDADKLSPGTGEFPLQTIEEVEEPGYAQRALDVSDELGIGLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSU0</accession>
    <name>A0A1C1CSU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sepH</name>
        <name evidence="7" type="ORF">CLCR_07895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSU0"/>
    <dbReference type="STRING" id="86049.A0A1C1CSU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07895"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06537"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000246">
        <property type="entry name" value="Putative Serine-threonine kinase SepH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF26">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DDB_G0283821-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="55"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1222"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1342"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1222"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1342"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1381"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1418"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1439"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1472" mass="163482" checksum="30255542CBDBFCE3" modified="2016-11-02" version="1">MPARTAEPQDDIPTARAVDGLGLKPSKTPRSPPSPVKREEREKTKAQDVAELKDYQLGDCLGKGAFGSVYRALNWGTGETVAVKQIKLADLPKSELRVIMLEIDLLKNLDHPNIVKYQGFVKTPDTLNIILEYCENGSLHSISKNFGRFPENLVALYMSQVLQGLVYLHDQGVIHRDIKGANILTTKQGLVKLADFGVASRTTGLHEASVVGTPYWMAPEVIELTGATTASDIWSLGCTVIELLDGKPPYHNLQPMPALFRIVNDDHPPLPQGASPAVMDFLMQCFQKDPNLRVSAKKLLKHPWIVSAKRSGSEKPKNATEYDEAVKSVQEWNEALKDSPNGSLVRKPSNASTASPVPVARDMLRSAKSQTKSPIPLLNKDNNATKFCSLEDDDNWDNDFATAISASTFQLPHLRPHDNFGGMLSSERLKSFATIESTWGKENEFVEDKDSTLKAVSPLEVDVDKTVRLATTTTKKRPEVRHARHKSEIPPKTRTKPAATPRKASLPSTRQPVDVHKMKPAQTRTQQHEPPTRRFRESSIEDFSDIVQGNELALDTKLGLMRLDNQAPSKILESPSVTDLIQSMRPPKAGGSLKRQPAPNNRLSMRRTRSSIEIQRFAENEQDEDFSDVFGQSSAVLEKAASEDGSELMLSSKISNLSWLPDAEDEDDPFAQLEEGLPEVDLESNIARDKHARLRTEVEALVGQLKVLQEDDALLQISEDLINYFGIFSETKSVIISAHGLLPILEILEDCMRLDIVLNLLKIVNAIIFNDEDVKENLCFVGGIPKINKFASKKFPREIRLEAAGFVKQMYEASNLILQMFVSAGGLTVLVDFLEDDYDDDRELVLIGVNGIWSVFELQGSTPKNDFCRILSRNSVLEPLSLVLNRVLMEPSDSGEQKELADLCEGRIASIFFVFSQAENYVKELVAERTVLHRVLKNLKRMAPAHQVTMLKFIKNLSMLSTTLDALHNSNAIDVLSELLSNNMNKPHFREMSNQILNTIYNLCRLSKRRQEDAALVGIIPILIKIVKQEKTPVKEFALPILCDMAHSTRAARRELWQNKGLAFYVSLLSDPYWQVTALDAIFTWLQEETARVEDHLLENQNFISAIVAALTSSKSTSFENLLEPLQKLLRLSPPLAASMARSSQLFDTLGQKLGHNKPAIRLNLLRIIGSICDSTEEGFFLLEQYSLYDVIRELSYSDSAVLVRSMAGELIRSCEESDNVSIKSGQGVNPVTNGARRKHPGFQRRTSSTTPPHLLDRQMSMPTSPQLGRSERASMNMYELPVAQTPRRQRNGVYVNGSSIMRPASRDGSTYARENSPAFAMPSLTRANTASVAEMTVNKSRVTRQPTVATNLAGQHRLSRQSTRESMVGSARSSAEKEPSSTTSSRAYQGRTNGSAAATATPVSEQRARREARHVHTSSISQSRNVNGSTHAAVSRPGSSQSQSQGQGNVEVTVARRTTARRNGAWDDRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTA1</accession>
    <name>A0A1C1CTA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09137"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06384"/>
    <dbReference type="OrthoDB" id="4115237at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="202" mass="22151" checksum="65F658F28CE81DBD" modified="2016-11-02" version="1">MQHARYQDMYEIPIIISTPDCHPVPEGQRDMTASGSNGPEMHPSPPPPASCLPGSHHGPALTTSLVSEGTQTDLPDETSISDDSPTTQSHGNSPFARTPFGAWTDRFYHHHISTHHPGNNNNNTTSPAESSLAPPETDLPNRPMTPRADLYNGQTSANFGMTFGPRPSPLRRGCSKPSTSPNSYEDQKHRMMMNWLERRGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTI8</accession>
    <name>A0A1C1CTI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfite efflux pump SSU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SSU1</name>
        <name evidence="11" type="ORF">CLCR_08552</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Sulphite efflux pump required for the secretion of sulphite as a reducing agent. In the presence of sulphite, cystine in keratin is directly cleaved to cysteine and S-sulphocysteine, and thereby, reduced proteins become accessible to hydrolysis by a variety of secreted endo- and exoproteases. Excretion of sulphite mediated by an efflux pump also represents a detoxification pathway for dermatophytes during infection of the epidermal stratum corneum, hair and nails, which are rich in cysteine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTI8"/>
    <dbReference type="STRING" id="86049.A0A1C1CTI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08552"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06293"/>
    <dbReference type="eggNOG" id="ENOG502QT02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.150:FF:000004">
        <property type="entry name" value="Malic acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT51825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="440" mass="49218" checksum="163B97A6F4F6D658" modified="2016-11-02" version="1">MDPAATHEDAPDGRPTCERHTAAEDLVASFSARNQHGWRRVVLNFTPSWFAATMGTGIASILLHNLPYNGDWLYWLSVIVFCLNIGLFGIFLFISILRYTMFPGLFMAMIRHPVQSLFCGTFPMGLATIVNMVVFVCVAHWGPWAITLAWTLWWIDVAVAVTTCMWLPFVIMHMHQSELSKMTAAWLLPVVATIVAAASGGIVAEVLPDRQHQLWTIVTSYVLWGTGFPLAMVVLVMYFHRLTIHRLPAREVIVSVFLPLGPLGQGSFALMQLGKVCAEVFPQTENFGPDSGRIVYGVSLVVALVIWGYGLVWLFFAVASITRSRFPFNMGWWGFTFPLGVYAVSTCTLAKEIPSEFFKVLGTIFSVAVVLLWMVVGLGTLKGALSGELLYAPCVEQYEKRLGRKDRDRMTNRRLPLRHWPWRRKGDDAGAKAVAEKQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTJ6</accession>
    <name>A0A1C1CTJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_08620</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTJ6"/>
    <dbReference type="STRING" id="86049.A0A1C1CTJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08620"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06284"/>
    <dbReference type="eggNOG" id="KOG2905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="53"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="276"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="350"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT51833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="386" mass="44297" checksum="89337E67309FDA1B" modified="2016-11-02" version="1">MATLQGTGIPKVKLESVPDENIKVEPSDTPSPFLDEDEDMDEDAGDLDFSQAQQQLWLSHIPRTLWQKLSQIEDDDEIEIGKIRVEGSESNPSRVSLLLYPNPVFENEPREYNLFAAPPEKQRSRRPGQAFVFSERDLAGYKPKSFTWDEVDEEGNPGQGRSNLYERHRREQKKKENKGRFVPYSRRPIPKQTAITGTVAREFEAVPVKNDEYFTLESKRAAAMLKVRVQEEALFRTGDDDPEKKSRNIYKSRAEAQAAAKANQARKRAAKENRAARVDKDVLVDKLMALFRQHRIWGLRDLKAKVNQPEAYLRETLEEIAFMWKQGDFNGKWELKDEYKQGDQMLLNPTGVEIAPKAEDTDADTKSGMDLDDDDDEDEFEDVVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTM0</accession>
    <name>A0A1C1CTM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTM0"/>
    <dbReference type="STRING" id="86049.A0A1C1CTM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07992"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06273"/>
    <dbReference type="eggNOG" id="ENOG502QTP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="435520at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="520"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="930" mass="102503" checksum="9367399A776139BA" modified="2016-11-02" version="1">MDYHSDIASVGHSYHYAHDRNLTSEPDTSPPQAGFAQLSTLSSLPETPSESVQVISSLIDSLSKISASTYVRQDPVAETNIHISTDEYSRSPSTEPPDADDLDREQNDPPLADESSEGEAAAPPVIKYARRPPPLSKRSSRSFIRSLSMSSQPALAPRESIHSLKSRAESDSVGLPSIERRNRSSAGSTFSFVSGLSSTLKRQTAESVYEMTTTRPIPPRRVSSDRRRKAESLYSMEQEKENKWPTRSPSVDGYSSSSTPLDQSPADGPTVAALRLSRGDLGSHLIPSRRSSLRRSVTGISDASQDQHNRYSFSGRDLKELNIDAELIEGDNSTVRRIRELQEAREKRQKEWRHEARKSERASKRHTIATPKLSSRRSSPYQSSRLSVTEVVVESPEVESPLDLSATVTPSDLAGMPAFATEPPKERPSSPVDARPATSNPPPSAALSRDNSLYQNAGTHTQRNSAGFTIKQDPALVEMKSITEEVEAFLGAPRFTQKIRHPRTGRTIAFSEVGDPNGFVVLCCVGMGLTRYLTAFYDELARTLRLRLITPDRPGVGASSPLSESQCTPLNWVDDVAVLCNSLEITRFSLLAHSAGAIYALATALKMPQYVRGRIHLLAPWIPPSQMPKGAALGPDSQPIANLPFTHKILSVLPAQILKVANSRFLTATSASVDTKPLKSKKNKQIQIESLEVHLDYPHRDLNEDSPFRADMPEVEPERPSTGTPNRARGMSCYQANNESLGIQGAAATSPKSDPRRQTFSAAKSPAATSRPMSPRLSPEARQALYNQTLTHRIWTLATQNANPASDLVVCLERRRPIGFRYPEVTRSVVIHHGAKDSRVPLDNVRWLRSVMKRCELKVLDDEGHGLMASASAMAAVLGEIAKEWEEWERIAQNKEKRKRSDAASTFSRGRSFHSRFVDASYREAASRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTS3</accession>
    <name>A0A1C1CTS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Bacteriorhodopsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_08816</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08816"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06224"/>
    <dbReference type="eggNOG" id="ENOG502QQVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018229">
        <property type="entry name" value="Rhodopsin_retinal_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00950">
        <property type="entry name" value="BACTERIAL_OPSIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00327">
        <property type="entry name" value="BACTERIAL_OPSIN_RET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT51903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="301" mass="33603" checksum="FE5B362441939F71" modified="2016-11-02" version="1">MESNQLHPLFKRNNAVSSNPTQNGKTAAIAVTSHGSDFYYAIMSVMGVVGLGVIIAGHMKPQRHRIFYYITGAINLTAMLAYYAMGSHQGWAPINVEYRRSWSKVAGINREIYYARYIDWFITTPLLLLDLMLTAGLPWPTIVWTIFIDWIMIITGLIGALTPSRWKWGWWTFGTVAMFYVFWNLAGVGRKRAKRLGQDIYRTYMLCGVLTLFVWLCYPIAWGVSEGANIIAPDSEAVFYGVLDFLAKPVFSVALIAGHWNIDPARLGLVINYGEDRASPAEEKAARDATPSVAGDTSVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUF0</accession>
    <name>A0A1C1CUF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynamin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUF0"/>
    <dbReference type="STRING" id="86049.A0A1C1CUF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07998"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10345"/>
    <dbReference type="OrthoDB" id="3598281at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="475"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="683" mass="75521" checksum="DABE6A1C0FF90979" modified="2016-11-02" version="1">MQSENSPDSPGRLTTPATSSDSSHSPSVPTGEDIDPDEPLPSIEMDPGLEATLTTEGDSSLRARSPSFSITPPTFGGNTVSTTSSTTPNGHDDSPTTPTMTQNGGHAAPTSPIRGLTASMASIGLGPDGLQSSPQSHRTLLSPQSPTPDRVDAAISPGSASRRHSRTPADRTPHAVTDEEPPHQRFYDPDVQLQLAISKGLVQDLVYALESSSLHDEPESRIRALYLQAIELSQYQNPSVRTVGLVGDSGVDRKGLARTSNIGRACTCVVTEYHYHENVNFALEVEYFTQEELRKQFTELLQSYRTHHLHDDTNMMADDRTDLQKKSRGLPVMDGTNMVPRTEFASADIFSDHLMGLTSEPADASEPSKWPFIRKIRVYLDTYILSKGLVLVDLPGLRDLNSARLKITERYLLHCDEVFAVCNIGRAATDPGIKEVFELARKASLSKIGIVCTKSDEIRADEAVRDWDGETKIQIQRMAKNVNVLEETAKRTQAELDEINSDSDSDLDVGMDDQMRGVREQLNRTLKRTRKSLARAKFELKKYLGTTRNQQVTEALRMLYENQTSAVDLAVFCISNFDYWEYRDEPKDQALPFLQLSGILQVRRRCLSLVVEGQLRAATEYVTNAIPALLGSIELWIQAGAGGVGAERKQAIRSALDRIELELEARWFDDEPALRGADNTTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUJ9</accession>
    <name>A0A1C1CUJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hprA</name>
        <name evidence="7" type="ORF">CLCR_08698</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUJ9"/>
    <dbReference type="STRING" id="86049.A0A1C1CUJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08698"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06016"/>
    <dbReference type="eggNOG" id="KOG0067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="29"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="123"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT52130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="356" mass="38524" checksum="2E2206E917A0BBE9" modified="2016-11-02" version="1">MPSASLSKPPPLPPGKDKHHIVVLEGIHAEMPPFDFPHTFDVHQRTAPSEVAERIKDATIVIACVVPVTPKAMDNAPHLGVLAVMAVGIHWVDKQDCARRGVTVTKCPAGNVDAVTEHFLGLYFAARKRVVQVHNIVTKTNDWVEKGSLTKLWPGGPPMGAGQETLGIMGYGTLGTRLEKLAKAVGFKEVLISERKNSPTVRPGRVSFEATLERATVVAICLPKEHDTIDLVGETELRSMRKEALIINVARGGIVNEHALAKALKEGWIAGAATDVLETEPAGLGTSPLIPDVANGDEEVPNLTISSHIAWFTQSTIKNYQRLLKEGVEGWVNGTLQQAEDKVHKVVVVHNGTVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUL3</accession>
    <name>A0A1C1CUL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter, FHS family, L-fucose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_08446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUL3"/>
    <dbReference type="STRING" id="86049.A0A1C1CUL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08446"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06005"/>
    <dbReference type="eggNOG" id="ENOG502QPVD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF3">
        <property type="entry name" value="PROTEIN TSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT52150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="516" mass="55900" checksum="6018F3546297981B" modified="2016-11-02" version="1">MSPRVITSAVERIARLDVQHGRMRVGTELRPRETVLPIAIASLFLFFMWGLAYGLLDIMNYHVKVAMGVSREKAAILAAGYYTAYIPGTLLIGGPLVKRCGYRVAMAVGLFILAVGNELMSIGAANCSLWGMVAGHFVIGLGVSTLERSANPYAVNCGPERQATLRILVAQAWAGIGTVVAPFLANAFIFNLDTSTVRPPTDPLHEGRCLMPDKAASGCDKLGSVITFYRLLGACVGSLALVISILFFRTNWFPEIAVPVPVNKTTGGWKLWKHPLVSTRFARVWWAFFANFVNLGCQVTFAQFFIEHMKVNACQSDNMAAIWMSVAQTAFVAGRFAAAGLVAFPKVFRPRWVLLCFIAAAVAFVGAGTGISAEAAIAVAVMVMFFEAPSFPMVFESATAGFDEWKASCETLMIVSISGGALQPALMGQLVERVGISPAWWLTAGCFGLVLTYPLAINLIPRFFKELDRAESGIGANEQTGADEETGLQRASKEGFRARVMDMVTWRRKSASSESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUR1</accession>
    <name>A0A1C1CUR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUR1"/>
    <dbReference type="STRING" id="86049.A0A1C1CUR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09044"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05927"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="244" mass="27700" checksum="27C1A77D682B3A71" modified="2016-11-02" version="1">MARDVIELLQVAGWLPSPLHSSIASTDTSPPGRDLHIIGISMGGMIAQELSLLIPDYMASLSLISTAPRLVRTIPFIENLRNRINMFIPRDIDVQLEEIAHRLFSTEWLAQEDTENEDPTKNFPTNRDRFAAGELQKRMDKAGFTRKGFTLQAIAAGWHFKSAEAIKRIGDVVGRERICVVHGTQDRMIDFHHFGMLREQLGGDDGGVQFKVWEGKGHVLVWEVEHEFNTFLEGRFEKCESMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUY9</accession>
    <name>A0A1C1CUY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09202"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="169" mass="18291" checksum="CB91DFFE1FB6A6AF" modified="2016-11-02" version="1">MATPGNEKTQSPSTQGDDDWFSARSLMASMFLKQGRAKQTGWGCQKTKDGPVTLEENPRLAQPSKVLCRFQVALDVTSSADDCTVACKESKTRWTRAGRKKPKPAPTPPDPRSRLDCLLSGLEARLRCPVLTAALEISGSARAWRPAPRKSHHPHHPGALSGDGSFGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV61</accession>
    <name>A0A1C1CV61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">yme2</name>
        <name evidence="16" type="ORF">CLCR_09580</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the YME2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV61"/>
    <dbReference type="STRING" id="86049.A0A1C1CV61"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09580"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03787"/>
    <dbReference type="eggNOG" id="ENOG502QS0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267654at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12433">
        <property type="entry name" value="RRM_Yme2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034260">
        <property type="entry name" value="Yme2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="198"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="779"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT52384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="849" mass="95630" checksum="98DD192AE0AC7B90" modified="2016-11-02" version="1">MILSRTAGRSLGRPGPLLTTFPRKQLLYTGRNARPTIRASAVAPSRRTTSTESGDNESGHILTQKNQGIFFFDNVFPLKLQWLNRIPYLNPDKFLADSLSKVNQPNLALADPGSIIKRALPEGLPLRVEKILPRLREGGAFVKFSHDEGINSTELESTLKQYLQEKPIRPWFNPLRRVRAFLVQGKPWIEDLYRLPTARLKVEFLPTAPENTAAELTQETLYSLFRRYGKLSEIASQPSDSKVTPKYGTIDYTRVRFATMAKNCMHGYVVPSEEGGGKTGTLLKLSYESKKRTNWIWDWMTNHPRIVIPILVALLTAASVAVFDPIRTFFIRMHVTHGLHMEDQPIIKWIRGQLLRGYDIIRFRKNKRDDENLRIVWEDRQGAINQLQTWLIETADTFIVVQGPRGAGKKELVVDQALKDRPNTLIIDCKKIQEARGDSNTIAAAAAEVGYKPVFSWMNSISSMVDLAATATIGTKAGFSETLDNQLAKIWGNTTTALKQIALAPRKKDDKDPQMADDEWLEAHPECRPVVVIDNFLHKNNEGSASLVYDKIGEWAAVLTTQNIAHVIFLTTDVSFSKSLSKALPDRVFRQITLSDCSPEVAKKLVLKHLDADGDTDEKTSTGEEKADASHRRSDLDELDGVIQVLGGRLTDLEFLARRIKTGESPGKAVRQIIEQSASEILKMYLLDVDVSTRKWTPQQAWLLVKELAANETLRYNEFILNDLFKDGETVLQALEQAELISITSKNGRPYGIKPGKPVYQSAFEYLTDDEVLKARLDLAILSQLIGQENKNVEKYEAELRTLADLPGTPSELKPRIHWCLSKAMASQEKVMKYEAQSGQLKKILAEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVH4</accession>
    <name>A0A1C1CVH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_09915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09915"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03923"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06178">
        <property type="entry name" value="MFS_unc93-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT52527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="501" mass="55227" checksum="18A1B5AAC1AD4269" modified="2016-11-02" version="1">MSFLYEPSFGKGKLRLNRPINQNFVVGGILFCLPGIYLALTGLGAGGGRPSSQTVASTTNAVLYGLFCLFGWIGGAILNLVGPKLTMAFGALGYPLYVGGLWYFDRQGHAWFPYFAGAMLGVTAGCLWTAAGFVQFAYAEEDQKALFITWQWVFTSFGGTIGSLIAFGVNYHQTESTGVSNAVYTVFIVIMCLAIVIALLFIISPKKVVRDDGTHIAIFTQPRVMEEIKGLIVWFTDYKILALIPGIFVAEMNLALLSSINAYYFNLRTRSLNNVLFQFIMMPCPLLLAYIMDTSYIKSRRVRGMIGALIVGIICLATNAGLAAWITKNDVNRQKNTPPGVDWSDSAFGAGFVLYLLSGIIYATYQIVVQWTLGALSNDPVQCSRLAGLFKGTTALGMCISFVLDSKDVSYIDQLIVPFTLYAVGLVFLLAIIWFCVKDTNYFLEDNVIVPHRWEERARIEGLVADEQIEREHQKEMLAQRGSVVDEKTLPSLEKGVTAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVS9</accession>
    <name>A0A1C1CVS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_10939</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVS9"/>
    <dbReference type="STRING" id="86049.A0A1C1CVS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10939"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03939"/>
    <dbReference type="eggNOG" id="ENOG502QQA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT52546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="156" mass="16515" checksum="4A6CE064FC4761B6" modified="2016-11-02" version="1">MLRVRSASPSASGYSGTGFWAGMALGRATLGFVTERFGERICISLYLALCLALQLVFWLVPKFIVSAVAVAFLGFFLGPMFPGGVMMAAKLLPKHIHVSAIGFAMAIGGTGGTVFPFAIGAIASSQGVKVLQPIILALLVVLLGLWLSFPRLKKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVX9</accession>
    <name>A0A1C1CVX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVX9"/>
    <dbReference type="STRING" id="86049.A0A1C1CVX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10735"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04072"/>
    <dbReference type="eggNOG" id="ENOG502S15T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="249" mass="27342" checksum="0FE7171D455487B0" modified="2016-11-02" version="1">MPSKPVIVFVPGAWHTPDSFHLVTAELQAAGYETRGVDLASVGAQTPLKDFWPDVEAIQRVLKPLADEGKDIVLVVHSYGGVIGNQAVQGFVKSEREKEGKKGGISHIYFCCAFALPEGVSLMDALNNKPLSWFQINDTQDTVTPATPIETFYNDVKEPEKYVNMLKPHSYRTFASKVTYAGWRHVPSTYLLCEKDEAIPIHAQKGMVEAAQQAGADMKVETVSASHSPFMSMAEEMARSIRRAAGESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVY2</accession>
    <name>A0A1C1CVY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVY2"/>
    <dbReference type="STRING" id="86049.A0A1C1CVY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09614"/>
    <dbReference type="OrthoDB" id="4485682at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF3">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="777" mass="89170" checksum="8E492AD71F74D3FE" modified="2016-11-02" version="1">MPEDEGFSSDDGDALPEIRRQEYLDLLRSDPDVQVTITLGDETIHRDMKEWKSWCRAWKQLTQESGEAVLESVNVRILNTYLRFKLDKARAAGKNVGIKAVRSRLNALARLHIVHLKREMDKKVKETVAYMLHQGGSIYNDYQFNNDNGTDDVDEPITLSLDDFNLLLYVGWTSKHSYFVAEGIRIRTHFLNLFCGYTGTRPGAVLGSDSEASRSNKRYLRFCHCKIVLLRGREEDPNARPLRVLEVILKHRKNKAKPLRVVFIFTENPILALCPVTFFLTAALESSAFHSGHGIRCMDDIDKLRVVPGRQTQELLWRDDMRDSPVFPAYEHNGTKWVPTNRPMPQQRVRKYLKKLSVAAHWGLRPITLYSIRRAVGTRLNGEPDVHAPLTTTLTPAYLETSTPAERNVILGHSSTVFQQYYLSRRATHDVQNAFLGLPQDSKVQELAKRVFRDADPRVQKSLSSADISRLNADPELFQLNTICTELTDRIAREKAKSKTVRAPPTDKTGRAQKALRRLPHSALLDGSGPCKEHMTLHMRKQEAKRRQRNVRDRLERREFPRIQKSQIQQLALRDTSDQLLGRPPEEAQLEDAELDANSPRRKIAALLFTEPDQHQYPIRSEADGRRRIEAVNLLVAHCGLQERRPTPSVKWKCEGELGLRQVKALEDESARARYDARVTGRSDLKMGPLDCIFCAFDSRRSRTASYTFSTKQSLIRHADRSHFHHLEDGSERNCPHPECSHELWYTADRLKIHAAKVHGVEFFTRTRTPGVREVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX92</accession>
    <name>A0A1C1CX92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX92"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10588"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="227" mass="24702" checksum="29F264008B8B519B" modified="2016-11-02" version="1">MASQLSTEARPGAIACESCRSQHVLNASAPELHARIQRATNGLEKRLLETELALFDTLALLSQYEGSQHSPRHRNSGVQLPNGHASAISSELLASHATHQAKISSLEEWAQLPLASEAQRRRWFEKKRTDLETLASGEPLSDAPKSQQQQPQFLPSAAVSTARLVRMSSSSSSANGTLDHSPPHQPRMPSQVQGPRAGQQQGSASPIAESTSSQAQRLSATQWRRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXD6</accession>
    <name>A0A1C1CXD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 26S proteasome regulatory subunit rpn3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpn3</name>
        <name evidence="5" type="ORF">CLCR_09875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXD6"/>
    <dbReference type="STRING" id="86049.A0A1C1CXD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09875"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04397"/>
    <dbReference type="eggNOG" id="KOG2581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="325"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="549"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="564"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="580" mass="64287" checksum="73FE6BC97B480DAF" modified="2016-11-02" version="1">MSGDKQNLNGSGPARNGVNGADDVDMKDESQNAKKGTKGSKDKDGDSDMTVVVPPAKGSNTPSAPSKATEADLTNGAVDGDIEKEAEEPVDPQEKAIEEIKANLPLLERAVSQFDPRFSLRVLRSIPSVRKHLTAYVLATVVTDTYSSPTATATSLLSAVKDDPTFPSQKAEEWHSKKDASPQKNSQKEVLPEIDVYLSILVQVHLYDKKSINAGAQFSSALVEHLRTLNRRTLDSLSARVYFYYALFYEEVAPQPPSPAAALISIRKTLLDALRTATLRKDQDIQASVTTLLLRNYLSTSHITQADLLISHTKFPDTAANNQVARYLYYLGRIRAIQLQYTEAHEYLTGATRKSPTAYKASGFYQASTKLLIVVELLMGDIPDRAIFRQPSLEKALEPYLQLVQAVSSGDVTGFQNLVQRYSATFQKDDTYTLILRLRQNVIRTGIRMMSLSYARISLRDMCLRLGLDSEESAEYIVAKAIRDGVIEASLDHERGYMKSKETGDVYATGEPGDAFHDRIQACLALHDESVKAMRFPMNQHRLELKNAQEARERERELAKEIVEGEMDDDDAPGGDFDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXJ6</accession>
    <name>A0A1C1CXJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_10130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXJ6"/>
    <dbReference type="STRING" id="86049.A0A1C1CXJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10130"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00167"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF215">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="6"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="442" mass="48102" checksum="6B03052D238E9097" modified="2016-11-02" version="1">MPHIQLNVIVAGGGIAGLTAALALRRQGHAVTVVESSAWLGEAGLAVAVPPNATRALIGLGIEPKRDAKAAAFRTSLEYHFLSKDATPRFGEDGDSRPLTWASRAAASHLEDLFFLAHRIDLHNALKDKCTSPTGPGKPVEVLLSSRAVSWDPTGSIKLQDGREMHADLIVAADGIHSVAHEAVLGYRVPATPSGVSTMRFLLRTEDILNDPATAHVMDDGPGSFTFYVNADRSTYLVRYPCHNDEMQNFGAYTVPGNNTTVVGEKVSRALLLERLSTLPPVIQALGRKADDYVFDWKIADREPLPAYHKDRLVLIGDAAHPMWPRQGQGAAQSIEDAATLGILMSQLEDEADIPKRLALYDELRVPRTSIVQQLSHSHGEGRQPQGPEDADEALSEEFSAVFRRFSTGATPPVDNIQLSRWLWGHDCTQEAEALLTRSKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY25</accession>
    <name>A0A1C1CY25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY25"/>
    <dbReference type="STRING" id="86049.A0A1C1CY25"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10535"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00355"/>
    <dbReference type="OrthoDB" id="5562676at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="258" mass="29603" checksum="DA4CEA06998732FE" modified="2016-11-02" version="1">MRKIILLPLTTRQALVYCQKAIEKPTSKPSIADRITKKAAETWAQWETAKKGWRKTLVYYGNQGLQRIPYQEWGLKSFPPSNPKLQAEQITEGRKFDVIFPSNVMHKEDVPKVLARLARERKQLHWNRFIGSMVAMPICIPFALVPILYRPVSPPEIEDLYEQVAPDAPDFTFVTSSQVLDGTAPPEQIILPAECHNLVAKVTGVPELSGEVERAVWQIQRQFKREQSQQEKQKRKQLQEPPKNDAEERDPKKKDSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYN5</accession>
    <name>A0A1C1CYN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">L-type lectin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_10428</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYN5"/>
    <dbReference type="STRING" id="86049.A0A1C1CYN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10428"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00601"/>
    <dbReference type="eggNOG" id="KOG3839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000095">
        <property type="entry name" value="Lectin family integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0430">Lectin</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651144" evidence="8">
        <location>
            <begin position="18"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="9">
        <location>
            <begin position="27"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT53654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="323" mass="35642" checksum="9CE285E08BA05109" modified="2016-11-02" version="1">MWSSLWLLAACAVGTRAAVEADPEMRSVALRTHSLQPPYLDSDMSSRWFDFGGDTIIRTDKYIRLASDLPSQSGWIFSRIPLTATNWEVEFEFAIHGKGHLHGDGFALWITKDRAQPGNVFGQKDQFEGLGIFFDTYKNNRPGVVFPYVMGMLGDGQTTYDAANDGKANEIGGCSARGLRGAAVPTKAKLTYFQDKSLSLQLQYKAPDAWIDCFSITPTADQPLKMPNTAYLGFSAHTGELSDNFDIISVETRNLYSPVAAQSGRDKHSQNRASGKGRSPKEQGGGWGWFFFKVLLFAGVAGGGYVGYKKYKEKQRYGGFKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYU4</accession>
    <name>A0A1C1CYU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF618 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYU4"/>
    <dbReference type="STRING" id="86049.A0A1C1CYU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10060"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00531"/>
    <dbReference type="eggNOG" id="KOG2669">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069473at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17003">
        <property type="entry name" value="CID_Rtt103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000030">
        <property type="entry name" value="DUF618 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047883">
        <property type="entry name" value="Rtt103-like_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="507" mass="54232" checksum="13C354A2A57EB1EE" modified="2016-11-02" version="1">MSFSDEALKAKLSTLNETQDSIVSVSQWIMFHKRHADRIANYWLTRLRDAPPPKRLNFIYLVNDIVQNARARKRSEFPDAFSPLMAEAIQTAYRSSPPEIQAKIRRVVEVWRTRNVFEVPILDAIEARMDEIDKSKGGGGKKKTLMGQSLFGSSSSTGGGLPKELETLAPLQIEVTKQTIAARPAIDAAQNEYTKLNEPGAVLPSPPVHAARLSSLIKSLAAAESSVSASIKARKALIADLERILEINKSALAKDDETYLTLDSRKASTEAKKREVEDAIIRGLTSAEASSATSTITIGPDAGTRTTPPGHGPETDTDNGPHSTSTGAFLSERPEIEQLTDDEGDYNNNTNTSPTTGMFDQDPPAPAPAPAPVSAPTSAPSTTPPPVRNPALAAALAEFSASGGAGLPLGLDVDYSAFLPSAGHTHTYTHTHTRPRTTSNGLPGAKRRKTSHGAEDEQVPDLGEMGIEGIGLPGLGAQQEQGQRQGRDVLATLDDDVDELIRQEGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ29</accession>
    <name>A0A1C1CZ29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ29"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ29"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10461"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00692"/>
    <dbReference type="eggNOG" id="ENOG502RNKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5352472at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="354" mass="39211" checksum="4D56676CE6A51AE2" modified="2016-11-02" version="1">MPTILLPASAAAFAPRSTCNVVLNTKVEPWLTATLKRINKIKRPLNSVPQHTRCLTETLSSPNAIWTLCSLMVPKAPESELRKDSNPLVEALFNYQLIHVEAYVVHIDMVSQNEVAFKLTTDTIDSLVEYHKEVFSIDTNANTWSWSEKEQQLKKLQEEFVQAANKFVYRTSALALEGMEEDGAGELLCGRSEEVRQAIMGLFVPLLPPPPRVVDVIRPTPLLPSSTGTEQWWPSHQLHALQPAPVEAWKIVPSSPSPVSSCDSHHNIWSSVGMNEIQLPSPTPSFSQPYSSAAYNTSQYYSAPAYSAPTTVSSFAPLPLPSMLAQQPCSTSASLSTFGWDRYQEYAMPYATAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZA3</accession>
    <name>A0A1C1CZA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZA3"/>
    <dbReference type="STRING" id="86049.A0A1C1CZA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09972"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00769"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="516" mass="56680" checksum="4958A7586BF30BB1" modified="2016-11-02" version="1">MVKFRGIEINVISQFDICKLPEFAATTFNHTDPFGIANRPENHAPPACPTAACYIPIYSGSQIWLEYTIDGPHPAEASYFFKLFVNDMVVTSWDCTAKHGFHGKMMYNLVHEGRGQVQRQALKFGDGMGNGQGEDIMRVHVYRVEKRVRVREIEQDTGRVNIGACRPDGLRLINSGLLEPSIRPRRYKYQLVDPVDMPYAAFRFHCRPIEFLEEQHMVPLRNCATPTSTESSVTSPNSGNVSIAPSAAQATTQGVAARPLASSSPYQATSTGDVLAEQKDGGTVEASARFMRIKPSESNDSLSIKTKDSIEELQSHVPRSPRSPASLKAKRDSEIPPSPTRSPKSPRRRLTKTLIVNTKSADSDVERAARPLSPFTSGGMLRKASLPPQTIPASVIEVRPTDEGEGKVMSQGHQAEIQAKPQKSTLRTSAEERGGKKFIGFLARRFTNEKSTKSDAHDAKYGLGGVMRVDKESRQTNAPLTVIGRGGHAAAECGNPAEDDCDVLIHRVHRVHASLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D004</accession>
    <name>A0A1C1D004_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_00154</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D004"/>
    <dbReference type="STRING" id="86049.A0A1C1D004"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00154"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02594"/>
    <dbReference type="eggNOG" id="ENOG502S2SN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF34">
        <property type="entry name" value="PR_SET DOMAIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="705"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="731"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="413"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="596"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="853"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="937"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="883"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="908"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1005" mass="111447" checksum="3329FE504CBF028F" modified="2016-11-02" version="1">MANRPSRQSVSHHPNLTGANASIPLEEEGSASASDFHLALSSDPDLRGIQAHFPGMIPTVGQTPRNSISSSNEHFLDLAAFENYSFDLPEGEPQYTLASSASVVNPRHLDSSAVDTGGVPTHRTGPDPWTHVDATVGPNTGLPDTMNANQHALPSGHLRTPTRALRPSSVGGRMTFEDSAYATASRKSQHASEAGAISEHGSDIMEQRNTNSTPTPTPYPAPLPGPTSSHSSTATLIPSSGNLQPSQPGRSPTRRPPRKQTELECPDCEYAAKTPSDLKKHSARHKREYKCTVRACPQSEKGFATVNDRDRHMKAVHRISNRPSKSYKCFAEGCNRGDKEWPRLDNFKQHLRKMHGEQPLYDLLQASNEWWEGQEAQQQAEADAASHARPHNLFPSSSAMSVSEQFEAYQRNYSDSNPSYMSPSSGSSDMLRSVSHGNPAHPADPASFLDPRLGRAQQFQRRSLSGPLGAGNPQRHLAVPLLNTILAPPQPHTQKTRSHADYSAYQDPSQVSTMFTNPTVNYLFSAGPSLDPSPFAARAGYSVPGGFVHEQPRRVKKARTVAGPDIKLYRMADFGSPQKVQPVPEDDRASQDAYLGYVGSNPAADNVPTPSPHQASVAQALEDSPKSKLHKRLEDDINSFLVQHNSKAGNQPLSEEELYKSFRLSLGSSDTLTSCDASHVGPLPGPTDVKQSPTKYWPATKETYFVCPVCKKPKKRQSELNKHMNRHSKPYGCVFDGCHKTFGSKNDWKRHEQTQHEQQECWRCHLCFEVFFRDESYYITHMSNVHSTQRPEESARQHRIARNYQGRFWCGFCREIIKHMKTDMEAINLRFDHIANHFTKDKMLSKDWVELSGKGKTKQQDRDQQSKTATEGGEDFAGMSQDTSMSTPTPTPTSPHNDSSPMQREFSHQSSGSEGLPSSTSIMQGLHSMTGLQTHTEPLQRQSHPAPEHAGPQPRRDAPQRRTKYVYCCHCGEMANSSLSDSCMPPCNHRFCPACFREERMDDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0K6</accession>
    <name>A0A1C1D0K6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipase D active site protein motif protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0K6"/>
    <dbReference type="STRING" id="86049.A0A1C1D0K6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00233"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10223"/>
    <dbReference type="eggNOG" id="ENOG502QUKR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9997422at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF22">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="650" mass="72587" checksum="E7FA1C3A38C39C2F" modified="2016-11-02" version="1">MIPKNVYELCQNGRSISTELASNPTLSPHDAAKKLFGVGADDEIVTKKLKLGEETSRDLEEARECGNWGPSNPSDLFLRIYHDVLCTLEKNPLVGVCSPSLMGSNGVCPLTVMAMVPDICRHMSNVIARAEHEVFLATNFWMYSEPTRLITNGLRELSKKAVLNNRKVVVKIIYDRGSAKQVFNNHLTVKAEEFADPNGKIRIPHPDELPNVDIEVVNFHRPIFGTFHAKYMVVDRRIAIVQSNNIQDIDNMEMMTQFEGPIVDSFYEVALISWHNALKPPLPLLDRPAAACPTPTFEAESHATMFDEHGKLRTVYHATSSVPEGADSLREIAEEGAQIDLPQHTSQDPHYDPDLKSEVLRAVAALNPRKGETRINAITRLLNTTIQPHTKGNAPEIEPADSMTPLIPIPRHDPFPIAMVCRQPWGAPNKHSLYTPQNEAFLSALRHAARSVFIQTPDLNAEALLPEIVKACKRGVQVRYYYCLGYNDAGELLPMQGGHNEMIAHNLYRDIGPEHRRNLEVYAYVAKDQIRPIHNKFKQRSCHIKIMIVDDHIGIQGNGNQDTQSWYHSQEVNVMIDSPLVVGKWIEGIKQNQNTHLYGKVESQGDDAGCWKDPETGEQAEGAIGVDPGRFAWARGVVGAVQRVRGMGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0M8</accession>
    <name>A0A1C1D0M8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CLCR_00812</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0M8"/>
    <dbReference type="STRING" id="86049.A0A1C1D0M8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00812"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01600"/>
    <dbReference type="eggNOG" id="KOG2525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="485"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="500"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OCT54322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="580" mass="64286" checksum="03C182692CDD9987" modified="2016-11-02" version="1">MATTTPAMSRTYNDAVNALNTLQSNFAIVDAIRKSGRSLNEQAIPEMIDWCRRIGYKPSDFDALNAIHIAGTKGKGSTAAFTSSILTQFIDCDEPGFRTLSKVGLFTSPHLTSVRERIQINGEPLSEELFAKYFFEVWDRLENAARDAGEDPASTKAKPVYFRYLTLMAFHTYISEKIDVAVIECGIGGAYDSTNVLESPVVTAITSLGIDHVGMLGDTIGQIAWHKAGIMKKGVHCFTPVSQPQEAKDVMEKVAREKGCLLEYVKPMPKIETGDYKLGLQGEFQKINATLALEVAWKWLRDQGFKSHDREFFLKVRNGLQNVRWPGRCDTRAENGIEWYVDGAHTLESIRLAGEWFASQLGTKPPPTHEPSNPLHPQPRVLIFNQQTRDANAFAEELFTTLSKALDDSRPFTHVIFCTNTTFKESGFKPDLVFANSNASEVQGLTVQRRLAETWAKIDPTAKVEVVRAIEEAVEIVRELARLHRQGRAENAERTTPTGERTKISHRHEMNPSSAKEETQSVSEEESKISSDQGPVVTAFVTGSLHLVGGFLEVLESTKGPDVTNPEGLPTSGPDDTKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1H2</accession>
    <name>A0A1C1D1H2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">dph4</name>
        <name evidence="14" type="ORF">CLCR_00969</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1H2"/>
    <dbReference type="STRING" id="86049.A0A1C1D1H2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00969"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10097"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF46">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="13">
        <location>
            <begin position="111"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT54561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="177" mass="20006" checksum="8A652ACAF0F679DC" modified="2016-11-02" version="1">MSSETQPHSYYDVLRLSRHDLGGLSKDDIRAAYRQALLTHHPDKIPGANRKGVLKAQPDEAPNTRYTIDEIVLAFETLSDPNKRVEYDRSLQDVGELGWKQVNGQKGTHTGVEVYDLEDLVYANASNTWCKSCRCGDEQGYILKEPDLERESEHGELYVGCRGCSLFIKVQFAVEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1S9</accession>
    <name>A0A1C1D1S9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">75k gamma secalin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_02757</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1S9"/>
    <dbReference type="STRING" id="86049.A0A1C1D1S9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02757"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04836"/>
    <dbReference type="eggNOG" id="ENOG502RK5N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5565328at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="908" mass="101136" checksum="F70549BEF221C0F9" modified="2016-11-02" version="1">MDHNYPYNNANWDGGFTYQSNGNYSQPGYAVNPYPQEPSNPNAQPYHPSSYPQSVQQNYPQYYSNQAQHYQFQFQQPSHHFYQSPPQPQPILPPVLPQSDIEVIVPRHPVHSAPKQQSQQPQQPQQPQQSQQLRDSYQAQYQAQGGVPSSPYQWTPQQKQQLLLQQQQQQQQYHHVSQSPQDHMRQAEQPRRVIEVPKPTIPQDKLVNHSSRHPSTSAAATPRRSPQQSRNGAFPSVEVKVMSPQMASRQPPPRVAAIEFDEPEPDYPTLLCVLADDYLEEARKQPALTERYYTLISKALGCLESVLANFKLPPLQEAQISLRYSRILYDETENHDEAETALTKSIELCERHKFVDLKYEMQLLLSKVLYESKPKAALRDIQRMIEDIEAYRHTVWLYIFRFQHAIFSLASSAPGEFHSAIVQLEKIAGLAKQNSDAGVLAFAATLEALLHLSSPSHEAVTATQNALAKARALQLNPDVESNPQMTILLEFIDLACSVRESNIAQSNAKRKGMVEVLDQIAKDGNWRADGSIYIPLSKQTVAGINLQAHKHVIERNGKYYIVFSWLGMEEVEALAYLFSADSSAYKNGIDGGKAEIFTTEGLSGVRALGKPSLTAGYRQSERVHAFQKLLEAEFLLLLSFLQCSKGQYNAANKSLGEVSTISEAVGDAFPLNMRYAMLYLRGVILQGTGDLVAALQVYQSPLFNLTPQQSSPWAVSSASYRKTSSCFPDSDVTRNFSILAAMNSAFIIQAPNHPQHNRLSSMIKSLDGAVQTCGNKYIQAHFSLLVAVLSGTTLTVKQYLKSAMEAGKAIGSAQTTALALIYMQEKLFKGVVDEQALKCAKAASQQTRRWGSPMWMHVTAGLEAQALDINGYENEARRRKQEGEAGWETLPEAIKSASAVGSGLAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2T2</accession>
    <name>A0A1C1D2T2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General stress response protein Whi2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2T2"/>
    <dbReference type="STRING" id="86049.A0A1C1D2T2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02734"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05136"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05137"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF16">
        <property type="entry name" value="GROWTH REGULATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT55044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="653" mass="69694" checksum="1D6344BF2FB47E52" modified="2016-11-02" version="1">MTDANVGKTDTSPANVNPETSATGNTGSHSELFGLQGQKRASTTAGAGAGSGVIGTSGHPGAGKGANIDFGQSAQTAGIGGMAEGGKSSAISGSGGEAFTPSQGTGDTVLSKIDLPLNAIDGVRACSPTTALSRFTNALDHDYDHEDKIYLAPPPHSPRSEASSSSPPSPRPPPFSSLYFPTDAELDQIRATVTEAGGDSLLVTAPAPSFEEALAEDDAESKAERETKAALPPDTKAQSSSGKALDDGEPPPPYTEGSSPLDSFTYVMAAAGGAASIITQVQQTGPPINTLGAGEAAADEHITLDLRLVPTGEGMEPGLDADCSCRGTHFTLSRDELLTLPEFVLLSLFPNGLLPDGHMNSFHEGDVYPVDVRSAQTPHPITVLSNPYIYIGDMTYSSQYDPASLQYMLNFFRDVAQSIPSTSPSPTTPPEHDPISIEPLQGSTKDMLQDRAGIIVLREDLDFYVIPPRADIEQPEMTEVKRAAGKSLLKQDGIFSGLKRSEEAGTTEQHLIEMLTAGGFNHDDTWGHRAGEPNKAVICSLALARLRTDIKGDLAGSNVVGMAQKLLLFWRKPARRCWWEGVELTDVEGVPGRLKVWIRRVWTLEMETTWGYRQYGRELAYVGDSYSVRDLDSKLCHRRRREFVAIAKAVRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6I1</accession>
    <name>A0A1C1C6I1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lactose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LAC12</name>
        <name evidence="10" type="ORF">CLCR_00609</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6I1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00609"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01079"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="41"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT44144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="526" mass="58639" checksum="5D015A36599D7EEA" modified="2016-11-02" version="1">MVNLKKGPTHADDVAIAQAEAPELEKVVWHKDPGLRKLYFYAAIICIASATTGYDGSMLNNIRILPQWTEYFNDPQGSNLGLLTALYSIGSIASLPVVPFVADRFGRKIAIIGGCIIMIIAAAIQGASQNLAMFKGGRFLMGFGNSMAQLSSPLLLTELVHPQHRGRITAIYNCLWNLGAIINTWLSFGTKHIGSEWSWRIPTIIQGAPSVIQIIFIWWIPESPRWLISRDRGDEALAVLSKYHANGNSAHPTVQFEYAEIKETLRLEFIAKKTSSYLDFGRTKGNRYRFLLVASLGLFSQWSGNGLISYYSTDIYKSIGITNANTQLELNGGMVIMSLIVSCTCALLCDRVGRRPLFLAATLGMLLCFIIWTICSAIYQDTGNKAAGQAVIAFIWIFNFSYALAWSGLLVAYTVEIMPFKIRAKGLMIMNFWVQVALVINQYVNPLGFQHLQPNWKLYTIYTCWIGFELVFVYFLYVETKGPTLEEIAKIFDGENAEVGHVDFDKTAIVSGMEKNEASVEHRAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6R5</accession>
    <name>A0A1C1C6R5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2 7">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_00643</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="2 7"/>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6R5"/>
    <dbReference type="STRING" id="86049.A0A1C1C6R5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00643"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01156"/>
    <dbReference type="eggNOG" id="KOG3892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264777at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF4">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="11">
        <location>
            <begin position="180"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="300"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT44233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="376" mass="41051" checksum="F8AFC84050AFE919" modified="2016-11-02" version="1">MDRTLKCFTNCLLCVSGELVAQDIYFSTEQGTITPNYYYRQEGVERIDLNGKIVSPGFLDLQTNGMKGVHFTHLAQNDGVEDDERKLQEVSEMEILPTLKPRTFASGADLLGAHVEGPYITASKRGAHNASYLVEPTQISPAELYGDHSLREAVKLITLAPELPGATTLIGQLQEEYPHVVISLGHSTATYDEGIAALQLGARALTHAFNAMNPLHHRLPGLAGLMSTGKCHYSIILDGIHLHPSVVTLCMRTDPRKCVFITDSIELAGMPDGLHPGHGQIPQWQLKQGNRVTIEGTDTLIGSCCTLDECVRNAVAFSGCNLAEAVQCVTENIADLMGERKRGKLEPGRRADFAILDGEGNVLETWIGGHKVWERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6T6</accession>
    <name>A0A1C1C6T6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6T6"/>
    <dbReference type="STRING" id="86049.A0A1C1C6T6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00578"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01175"/>
    <dbReference type="eggNOG" id="KOG4388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5570009at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="236"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="465"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="740" mass="82979" checksum="EA8A537BD0B29DC4" modified="2016-11-02" version="1">MDRPCAREAVFAVSQIPSRCSRVILVTILAEVWFLSLATSGDILTSSRGDKHGPPVLRTLSQRLAKRLTPWRSVVLTFLWLYMCRNFAKIVGLESPEPLANLYSRAFFRATWVTTALDAGFWSAMKIRNKPLRDLCSMIFTIYYLFAAEQAEEKVRKVRAVLTVDHLRVAWNKPTTPYLKFFTALMRPRFTKYKPRRIRIPRPKQSHYKEPVVAWMYFDGTLAELEKQENVVLDIPGGGFVAMDPRTSDDKLLAWAGRTGLPILSLDYRKAPEYPYPYALNECFDVYTQIVATRGRCIGMKPDSCPRIVITGDSAGGNLACGTTLMVIQSNQTGTSRGILPSPAGLVLLYPALDFNIGSWMTDDQMALIRNPRTAKKYERFIKRKSEDIDRRYTPTTPKPTSDDDDDEGDPNHDFFAPRGGKSEIQPGGRHQTTDIEAQKQAVQTSKPQTLRTRLAVSSIISYFGDRILTPEMMRAMIILYVGPYNRPDFTTDHLLCPAVAPEGLLAKFPKTYFLTGERDPLVDDTVIFAGRLRQAKLHLFRDRQEVGLEKSTTEFNEKDHVEVTLIPGISHGFVSFVSIFPEGWTHIFRCGRWIADIFARPPHMFEGPSIEARLRNGGTLHHLDSGSSLELATTEARHHSRRPTGESMDDDAPLVMSSLTPSKDPTAAAAAATTTTAGHANGVVKGEHSRQKHEGRDDKSSEQERLARNKSLVSLGSEEDLLKRRMKGLTVGLLGSQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7S2</accession>
    <name>A0A1C1C7S2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATP-dependent helicase HRQ1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HRQ1</name>
        <name evidence="6" type="ORF">CLCR_05394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7S2"/>
    <dbReference type="STRING" id="86049.A0A1C1C7S2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05394"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07226"/>
    <dbReference type="eggNOG" id="KOG4150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014939">
        <property type="entry name" value="CDT1_Gemini-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08839">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01075">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="371"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="594"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT44546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1148" mass="129541" checksum="2F8D0CAFC6157891" modified="2016-11-02" version="1">MAKLQGATVSRVPVNRKRKRQSNDAEVQSTDADSVTTTSTTTTVPTKGHDGGTKPRRTKASSKPAMLRRNSSSNLVETEIVWPEHFKYLSQLHRALNLVYTFCCTRKHFATTWDNIKAAVEGHIKRPLVEDDVAQVKALVPRAINFAYVDEEHLLVTLMGEDDGVKGGRAEHFRSLQEDESGPKDPPGEAKELLLFEFIDGDLKRQVIDPKTGQPTKATNKLRNEDLKMPVFSQKSMLRLIEKRNAKFTSAINSFLNQCAEEQKDAVEKIMEVKQQYLPYPSTSRHATPAPQVEIVPKAIPKERKSIADIVKEISESEWYTHQIVPDGHRVFDPQPAIYGDLSFPLSQNLVNALYNCKNITRLYSHQAEAINNLHDGHHVIVSTSTSSGKSLIYQIPMLHELEKDPESRGMYIFPTKALAQDQRRSMKELLKYIPGLEHTIVETFDGDTPMGERNHIRDEGRIIFTNPDMLHITILPQESGWRTFLQNLKYVVVDELHVYNGLFGAHVAFIMRRLRRICAAVGNRKVKFISCSATVANPQEHMKTIFGVDKVKLTDFDGSPSGRKEFLCWNTPFKDPGDHSSGRGDAFAETARLICQLILRGVRTIAFCRVRKQCEVLLAAVKAEFTNLERPECAALVMGYRGGYSAQDRRRIESEMFSGRLMGIIATTALELGVDIGSLDAVVTMGFPYTIANLRQQSGRAGRRNRDSLSVLVGDSFAVDQYYMQNPDEIFTKPNCELQVDLTNELVVEGHIQCAAFEMPIKPDEDEKYLGKMVTEICVDRLTYDPMGFYHCNPRFRPLPSRCVAIRDTEEDHFAVIDITHGRNVVLEEVEASRAFFTLYDGGIFLHQGRTYMVKEFSPERKMARVQLVKVDWTTQQRDYTDVDPIETEQVRRVSATSLTKAYFGRIKVHAVVFGFFKVDQKRRILDAVAVDNPPIIIHSKGLWLDVPKYALQILQHKRLNLAAAIHAAEHALMSLMPQFVVSMPGDVRTECKNALKEFAKKETQRKRPARLTFYDAKGGPAGSGIAAKAFEFIDSLLERAVRRVAACHCLEGCTECICDERCKEKNMIMSKAGAEVILKSLLGMEIDVDALPEGEEERVPAGVETIVFATEVMGRDGRRVVEREDVFVKKEKNDEDAIVIKDEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7W7</accession>
    <name>A0A1C1C7W7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">iml1</name>
        <name evidence="9" type="ORF">CLCR_05337</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7W7"/>
    <dbReference type="STRING" id="86049.A0A1C1C7W7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05337"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07297"/>
    <dbReference type="eggNOG" id="KOG3572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057068">
        <property type="entry name" value="IML1_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24438">
        <property type="entry name" value="IML1_N_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="DEP" evidence="8">
        <location>
            <begin position="1298"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="610"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="688"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="794"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1386"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1640"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1697"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1843"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1906"/>
            <end position="1944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="809"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="902"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1643"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1655"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1734"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1843"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1925"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1935"/>
            <end position="1944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1944" mass="214910" checksum="6303D279CBB1B69B" modified="2016-11-02" version="1">MEQKTAHRRTSSGSTLRASLSAQSAPPPAPSVRASLWIHDDNFSPEDVLINESVVEDLGIREGSLIRIYPAPETSDVRDFQSPDGEQGDSRRNTGPLTDGDGVSGWKDHYLCIAKFAPAEFKAKQANLQVSIKGHIATAFGFRPRSHVRIVPTSFEDCTASHVEFSFRDTYLARSDMWRLVGQELAGRTVYAGQRITYMGTIKLTVKAIHVHHHRVSTAFFAGTTIPIFRSEAARYVLFIQMSSEMWDFDSEGDGEIMFNKVINGFLPDLFKRWTDLEVRHLVSIVLFGRLEYDKVDLARNKDRRLEVAPASGAPNMTARQYQDFYRVVVTDMASAQWTTILDELKKDFRVFLRDISLHTSNHDDIIDDDTKARPVRIAGRPSTAMKGNILEAINIASTQFAHDFEDRDLIRTGVSIVVVTAGTGVFEVNRDLLNLTSQNLTNNGVGIDIVCLSRMPLHSVPLFKYRSLGAEEPLLSSLTEDAGSQDRHYSSSTSFFDSVQPRKLSPAVSSTATNSTRFFASFMSGRSNDGLHGWSYGIPQWIDLSYWSADIEPLEVKVVEGPSKTTGPASGRKKGPFVPRVRMYEIQMMGLMELGMADMSIPYMTETQGAAAGRVKRRTSKRQHTSGSRSLSHSPTLSRKSRLSAGPRRPAPGLLSSHAKAFGSVFDRMDEYDSALFQTQFNSEAASKAPKAQSRASAVIGTASPNSSEKSQPETKAPKSGSGLTKVLTNKSLNSPFRPQLPSLVSADASSPNMTIKKTPEAAKVNRTLNYALRGLAPPMRAVASTEVNITNAQAQPPFGNPGHSRPTVATTAASIRSVSTNSVLAEKNNASPAASQRSPRFQGRLDNAPSKPISINTPLRKVRDDGLGESQGSDSTARRLNDHISVAQADTGSKHESDSDSSVSTESDISDSSDGVDTADSQLGLSVASSVPKSALPFVRNVNASNPLKRHPERETLYGRWQHLYPRKPRAATVKWRSLCTPASVPLTTEDFPTRDELEMDFDSATYELTLTHSNELLEEPESRDILLREMLALRFAHGYQLVVGPALLEAVGPGTCDSSSFFTPNLVRPDGSFIVMSMGNTIQKISLQQNDRLQVTKYLRRPPAVKPSAPQHISYYPNIRTILSGAYKLRDMQFSGFSEQYPWEAADKYLENRQRQPDVDVQALRFWRARFVLIPVAPPANSWRPASSEPEESEEEIHLRGIRALTQMWQRARYVPMDERRPAHNRLSTVKRKDRNPLRINLETLNPSELVATELDKLVAAEEAGESQNTQLLPEAEQFDRDSFALPKLAQALQGENGIEIKTRRWHWRLHYSCFMGEDLTNWLVHNFRDIDTREEAVELGNELMKENLFEHVNSKHNFKDGNYFYSIKPEYRTQRADARQSWFPASRRSERSIPPTPAIEQPNREWLGGRSRSGSNLAVHGQAASELAKTLADKKKRTVTLSKMIRIDVDTRKRSNKPEIVNLHYDRIHNPENCYHLELSWLNTTSKLVDDAIVGWTTQAEKYGLKLVEVPIAEAFKVPEHEPFRAAYRVKLALDPPRRSAATSMYFTAVAFGPQTPLKEDVHFYQKALLKRFNFVLDLEAPSEFPENVEIKYSWGDLDYRYTQFVHRSGVCLAQITDEGDFLLLANRLYNSRQASAKETSKFDTSKKDNLTPNTSSSMLMRPQTLTSTHSAPPPSMQASGIIGLNVQSPRTGPYASPLIRPLKSTPMPPTMLDSRASSSLDTGIGTGNGTNPSSTPSLIGPTMNNNKNNHQYQPVPYTNVTIPQTPKITADVLGTRRALIASGLTHYVTPEQIKDDIESFCQDVAQLDDFYKEVTATLLPALQASLRDGTAAVAAAASSSSPQMGASMSSITTTNVNGNGNGKEARVRTGKTSSSLLRPLREPVTVSEGIGMGMGVETIPEFKLPGPKYGPVRKQQAETGGTGGSGGGVSAEQGAIDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8L2</accession>
    <name>A0A1C1C8L2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acyl-coenzyme A synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8L2"/>
    <dbReference type="STRING" id="86049.A0A1C1C8L2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05733"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07546"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF194">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="453"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="555" mass="61888" checksum="26D437E9E51C1F5A" modified="2016-11-02" version="1">MPYSSPFPPLDIPKCNILSYLFPPGKTPSTKPLWYDAADTSHNLSPAQMLSWVKRFAVGLDRLGVKQQEAVMVFTPNHLYVPMAYLAAAGSKRFFTGANPIYTVNEVAHQMKVIEAAVVLIHPTLLETGAAAAKQANIPPNRLFIFSDSEHPTTNGIKDWRSMIASESEAESWEWDPLEGEAALKTVAAINLSSGTTGLPKGVCITHRNLVANAAQCIFNKYEGTEYSEQNPGPERWLAFLPLYHAYSQLWTINIACRLHVPVYVMSKFVYEDFLKYIQKYRITTLQLVPPILIMFAKRPETAKYDISSLKQLLSGAAPLKSDLQNEIMDRFNVTIVQGWGMTETTCAGIMMPGMNKDLTGSIGHLLPNTEAKIIDEDGKEVTAEGEPGELWLRGPQMLLEYWRNKEATRESKTEDGWFKTGDIAVRKGDKWWIVDRKKELIKVNGLQVAPAELEAVLLEHEDVADAAVVGITIHGEELPRAYVVLQERAKGKTTEEDIKAFIAGKVAKHKRLAGGVKFVDEVPKLASGKIVRKLMKEWAKRDAQEIEASVKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C920</accession>
    <name>A0A1C1C920_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear pore assembly and biogenesis-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C920"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06340"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07683"/>
    <dbReference type="OrthoDB" id="3559694at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024316">
        <property type="entry name" value="APQ12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12716">
        <property type="entry name" value="Apq12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="20300" checksum="BA209014833AD90E" modified="2016-11-02" version="1">MTPPPPQQQPTPALPSFIHHFASLYDSYILPQLPDPLQSVSNNVSPFLGSMLSAASNGDVVSLAAFLLTVYLSLKIADYIRRSVIGWVVFLVKIVVVLALVQAAFYVNRNGLQKALGDAEWVVGILWGLVEDKVVGTGDGRDNRTGGYGSGYGNGAWGGSSSGSGSNSHGGRRQQQGLGGGRGRQKGRSAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C998</accession>
    <name>A0A1C1C998_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_05418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C998"/>
    <dbReference type="STRING" id="86049.A0A1C1C998"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05418"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07730"/>
    <dbReference type="eggNOG" id="KOG0472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF46">
        <property type="entry name" value="LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="755"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1002" mass="109974" checksum="1E17AB74F570840D" modified="2016-11-02" version="1">MDHHQEQGSHIPIRGSSLSHLSKLPMPRAMASIDNLKLSARSSTVLDIHHDEPRKISHLPRPTGPPTPLRENFNQSIRSRYGWADKPANVRSRSPVRDALTDVQSSAMVTTPPGTFSDGPVFVAGNENPTSKPGMNDMPRPREASPTPSHTSSRPDSPNKRPFRPPGRMSPTKDMTTLPPVVSPGEIYTPPKAFVKGQRSRIAKPLREPRRSASSAFDIPSKEPNAAPPSKYTSQTVKVQPTYGQRAVKSPTLKSKGSLSSLFREPPSSARSSSKVAVSGVGSSAALLKPRSRGENTLAPSTPPRANSKAKRDTMLHQDPTVVTLKASQADTPPKSSAALRETIAKAKAAKRKARESAGLTDVSSQDPSSWPTSFVEDDLSYGGDNPGLLRKRIQQATASGYLNIAAMNLKMIPTEVMHMYDPEHLTTNWADLVDLTKLNAADNDLEELNEDMFPDVTRDDGEMNHQFLGLEVLDLHRNRLTRLPEGLPMLERLHTLNLSGNKLTNDILDIIGRIPKLRELSLADNSIEGELDLTRAGSSNCDCLENLEILDLHGNAVSSFGAAGLRTLKHLRILNVAGNKLSCLDWQLLSTSTLTELNISKNRFSGVLFSASGLSFKELRSLDASYNELESLTPGDDDAGTLFSSIRTLNLTANKMTSLPSLRSLEDLLTLQLADNKLSEIPADFTQLESLKSADFANNDIRLIPAELATMANLTSINLVGNPLREKKYLTMGTADLKLDLEKKLDPTEAGDNPTETSPADAVSNSQYRYTPSNGTLDLSSQTLSTIPMELIDLTSEVHTLKLSNNELASFPIELLSHPSLKYSLQSLDLSHNPQLHPTDYLTCELFMPYLKSLYIVSTGLTSLDALTTYLRAPELKEINISCHKLAGHVPWVRAWWPKVTTLLATDNWFNSVDVEGVRGLEVLDIRNNEIEALPPKIGLLGNLPGSKDKIPGRLRVLEVSGNRFRVPRLVVVEKGTEAVLKDLRRMVKAEEVTDEWRDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9B3</accession>
    <name>A0A1C1C9B3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9B3"/>
    <dbReference type="STRING" id="86049.A0A1C1C9B3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06418"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07721"/>
    <dbReference type="eggNOG" id="ENOG502SBZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="532630at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="136" mass="15171" checksum="E9BFCECF2EB5B391" modified="2016-11-02" version="1">MSVCGNQAPVESHDILLEAEMCCDRACVTPAFAVKIIFAYETAGPPDELVLTRCTTGCEEIMNALDECHARGFLYKATGGCNDIKREVNRCLSGERTKKSRNNRETALERRARIEAVWAKFDEGDFSALEQFTKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9P7</accession>
    <name>A0A1C1C9P7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9P7"/>
    <dbReference type="STRING" id="86049.A0A1C1C9P7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05863"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07854"/>
    <dbReference type="eggNOG" id="KOG4127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008448716" description="Dipeptidase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="434" mass="47443" checksum="BA801FEEC5D71D1C" modified="2016-11-02" version="1">MFKMLPAAALLLTFGFIAHVDSASGAAGSFLDQAIKLMEESPLLDTHIDLPQIIRSLNRRPLDALPQLNGSFPGHVDIPRMRQGRLGGAFWTVWAPCYDVVDEDPGPDFNTPTNHLRDAMEMLDIIQNMIARHPGDLQYARSSAEVCDAFRAGKIASLIGMEGTHVLGNSLGVLRIFAQLGVRYLTLTHTCHSAFASSAGPGTPIGQAHKGNGLTELGKELVRELNRVGIMVDLSHTTDATMRQAIAVSEAPVVWTHAGARALWDHPRNVPDDVLSLIGDGPGQKDGVIQSIFFPPFIGPNPGANVSRVADHMEHIAGIVGRNRVGIASDFDGMWTTVDGLEDATKYPNIVAELLSRGWTPEEMRGVLGGNLMRIMDEVDAVSERLKERLPSSAIWEKRKDLPSTKWGGGGEHVYWPRDVKEKVENMQLRHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9R8</accession>
    <name>A0A1C1C9R8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_05950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9R8"/>
    <dbReference type="STRING" id="86049.A0A1C1C9R8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05950"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07929"/>
    <dbReference type="eggNOG" id="ENOG502SDAI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3692311at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT45280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="392" mass="41931" checksum="5E52A2003F11750C" modified="2016-11-02" version="1">MGFENKSIYTPDLMMAHIRRQDAFDDSDYVSCPVGGEWWKCEDVNYPTFIGCCSSNPCSGQMCPEDGLYPMGFGSVTTPTPDYPNHSCPYGGLWYTCAANTVPFQGCCESNPCNGQGCPASDLRAAAVHTVVVAGTSTFTVPSSVATKGPTTTTSTTDTTTTSEPTGAGSTSASSEPVSESIDVAAIAGGAAAVAVVLTVILGVLICWLVRRKRMRQAEINSAQAGTASQDPKPFYKDPFGAIISPLPRYSQRSPSFGYSQAPFSPAPTYQSAHVTHPPHTEPQEVMGLGLSEVEFNRRAKSRSPANHHVDGPIELATQRFSTTNPDAEAKSPLLEARPKQKPKPNSRAKRENEDTYPRQSRLRSRAALVDLRAQASRSPSRGPAEGFGPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA04</accession>
    <name>A0A1C1CA04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rasA</name>
        <name evidence="10" type="ORF">CLCR_06265</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA04"/>
    <dbReference type="STRING" id="86049.A0A1C1CA04"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06265"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07956"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT45316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="219" mass="24671" checksum="2BBB0B3CD5DACBAE" modified="2016-11-02" version="1">MARLTQQPLQFLREYKLVVVGGGGVGKSCLTIQLIQSHFVDEYDPTIEDSYRKQCIIDDETALLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSITSRQSFEEIMTFQQQILRVKDKDYFPIILVGNKCDLEGERVVSKEEGAQVAQQFGCKFIETSAKSRINVDNAFYDLVREIRRYNREMSGYSGGAPALGSYGLGQKPETDNQAESAGCCSRCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA36</accession>
    <name>A0A1C1CA36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA36"/>
    <dbReference type="STRING" id="86049.A0A1C1CA36"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06167"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07942"/>
    <dbReference type="eggNOG" id="ENOG502SWQ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="122"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="198" mass="22006" checksum="07D14AD0F4B4381E" modified="2016-11-02" version="1">MADTFGSIRIVTQDGSHELEIKDVPRAQRFENFKSRVAVELGRAEKRYVNPGDLDLFVFSEKMEDKDRTLADYGIKDGAIVTRIDHFNGTNRRAQTNSTPNLNPDQASLPPYSGPPTGKALDNVFVKLDHRTINLHGLTTTSTIQELYDKLKEEAKVSQANTGLIFGSKELRPNLTLRDVAIDNNSTIFVFDKLPGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAE1</accession>
    <name>A0A1C1CAE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_01608</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAE1"/>
    <dbReference type="STRING" id="86049.A0A1C1CAE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01608"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03421"/>
    <dbReference type="eggNOG" id="KOG0750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409947at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000010">
        <property type="entry name" value="Probable YHM1 (Mitochondrial carrier)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="219"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT45510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="309" mass="33106" checksum="1034E4E9838CAE30" modified="2016-11-02" version="1">MSPPAMAPALGMAGKEYKRESGTARLLGSGSAGVAELMVFHPVDTIAKRLMSNSTRVASVSALNKVIFKDYASAGAVTKFTSLFPGLGYAAGYKILQRIYKYGGQPFVRDYLTQHHSQDFDKAFGKGTGKAILNATAGSLIGIGEIVLLPLDVLKIKRQTNPEAFRSRGFFRIVADEGMGLYRGAGWTAARNAPGSFALFGGSAWAKEKLFKLEDYNAATWGQNFVASVVGASASLIVSAPLDVIKTRLQAASFETNESGFSILARMAKNEGFTSFFKGLTPKMLMTGPKLVFSFWLAQVLIPAFGNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB00</accession>
    <name>A0A1C1CB00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_01587</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB00"/>
    <dbReference type="STRING" id="86049.A0A1C1CB00"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01587"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03557"/>
    <dbReference type="eggNOG" id="KOG4130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="154"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT45656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="344" mass="38946" checksum="EDF6A302BD6CA2C1" modified="2016-11-02" version="1">MAPIDFFTNLKNTYFSHEDKDKPAISTTTAALLSVTFTLAYVVPFYLSAATRPSPTLNRDAPSVIRARIRTVTLACITASAAALYMLTRTAKLALVDALHMLGWWPILPFDFLRALALTLLLYIGPLFEKVFVKRTLDDLRHGGLRPVVESLSSWQGYRNYVAGPITEEIIFRSVLVPIHLVAKVSPSKIVFLTPLYFGIAHVHHCYEFILTHPHAPILHAVLRTLFQLTYTTLFGWFAAWIYVRTGSLYACVMIHAFCNWVGLPRFWGRVSRREEYPLSPVAIRGKDDRDVVQAQGHGKKLHLGWSVAYYVLLVTGAYLFYRELWPLTVSEAALAEFSRKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB69</accession>
    <name>A0A1C1CB69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription initiation factor TFIID subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">taf5</name>
        <name evidence="11" type="ORF">CLCR_01431</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB69"/>
    <dbReference type="STRING" id="86049.A0A1C1CB69"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01431"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03599"/>
    <dbReference type="eggNOG" id="KOG0263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="10">
        <location>
            <begin position="85"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="488"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="530"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="572"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="622"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="653"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="653"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT45702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="771" mass="83593" checksum="AE4A8DD356ADC5D7" modified="2016-11-02" version="1">MEECSKPPEESQRPAEQTAPYAPVAAMGSPHLSDGSTEQESVTGEEAVIDYLAKKGYHRTEATLRAESSNQEVPKDGELRPQPTGPPRYYEMFLRLRAWTDDALDIYKPEIRRLLWPIFVYSYLDLVKQFYPKEAQRLFQKFAEDFRKEHEYDLRGLEHITLPEHSDQDKVAKIYRDNKYRLALSSAAYVYFMQFLESLPQQGYKLFISIVENNMDLRQTDRGADDRFSFASVIQRGIDGQDMPAEDEGIPGHRPGNAVSSTDPTVGNNLATLKLGKLPMEKDAEEDVRGDLEELDLKCPPVPGQPTLVQTHDLVNIKQEDEDEGPSRSEIPYPPSTARDVAMEVQKIRENRDRLKIETRTGGIGPGLSVVMYTFHNTHDSINCLDFSGDQKLVAAGTSESYIRVWTLDGSALGPAGPNGQKQNSQRLIGHSGPVYTVSFAPATVNPADDNPTEGATADTSPQWLLSSSADASIRLWSLHVWQCIVVYKGHVGPCWSVSWGPFGHYFASAGHDKTARIWLTDKIRQVRILAGHDDDVDVIAWHPNSAYVFTASSDKTVRMWALNNGNPVRMFTGHTSMITALACSKNGKILASADDTGVILLWDLAPGRLLKKMRGHGKGGIWSLSWSAESTVLVSGGADCTVRAWDVAGPAKEASGSSAAGGAAGAKPTDGTTQAGSEAGGPKSATATTAPSNFNLQSGTSSGSAGVGVGGVSGVGVGGIAGGKRRAKDAVVTSDQISAFLTKQSPVYTVKFTNMNLVIAGGAYLPEQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB91</accession>
    <name>A0A1C1CB91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">citA</name>
        <name evidence="8" type="ORF">CLCR_01546</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB91"/>
    <dbReference type="STRING" id="86049.A0A1C1CB91"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01546"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03685"/>
    <dbReference type="eggNOG" id="KOG2617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06105">
        <property type="entry name" value="ScCit1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="487" mass="53501" checksum="DC6820597B2560F4" modified="2016-11-02" version="1">MASSLRLGSSLLRSSTRPLVQKAAFNGVRAASTQVSFPMNQLRASSLTVAVRQTLKEVFAAKLPGEVEKVKKLRKDYGSKVIGEVTLDQVYGGARGIKSLVWEGSVLDSEEGIRFRGRTIPECQEVLPKAPGGEEPLPEGLFWLLLTGEVPSEQQVRDLSADWAARSDLPKFVEELIDRCPSDMHPMAQFSIAVVALEHTSEFAKAYAKGINKKEYWSYTFEDSMNLIAKLPTIAAKIYRNAYKDGKVAPIQKDKDYGFNLANQLGYGENADFVELMRLYLTIHSDHEGGNVSAHTTHLVGSALSSPMLSLAAGLNGLAGPLHGLANQEVLNWLTKMKQSIGDDLSDKKITDYLWETLNGGRVVPGYGHAVLRKTDPRYVSQREFALRKLPNDPMFKLVSQVYKIAPGVLTEHGKTKNPYPNVDAHSGVLLQYYGLTEANYYTVLFGVSRALGVLPQLIIDRALGAPIERPKSFSTDAYAKLVGASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCP2</accession>
    <name>A0A1C1CCP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CLCR_01190</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 13">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCP2"/>
    <dbReference type="STRING" id="86049.A0A1C1CCP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01190"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09262"/>
    <dbReference type="eggNOG" id="KOG1394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000015">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000024">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="14">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="12">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT46259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="427" mass="45020" checksum="919FAC8ED00524C4" modified="2016-11-02" version="1">MRRVVVTGLGAVTPLGVGVRRTWARLLDGHCGIVSTRHLGDEFRSLPSQVAGLVPRAVEDGGWRAEDHLSPTEIRQTAQFAQYALAAAEEAFQDAGFKDGNGLDPEMAGVTLGSGIGNLADLYDTSLAYAQGHNYRKIHPLFVPRLLINLGAGHISMRYGLRGPNHAVTTACTTGAHSIGDAARFIQAGEADVMIAGGAESCIHPLAIGGFARSRSLVTAFNDEPGKSSRPFDKDRAGFVIGEGAACLVLEELEHAKTRGARTYAELIGYGNSADAHHLTAPLEEGGGALLAMKKALKQARIPPSEVDYINAHATSTPLGDQAENKAIKTLMLSEHGKAAAKDINVSSTKGAIGHLLGAAGAVEALFTVLAVHENVMPPTINLVSKTEDFDCNYVANEAQQTQITVALTNSFGFGGTNSSLCFRRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDM2</accession>
    <name>A0A1C1CDM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ade5</name>
        <name evidence="11" type="ORF">CLCR_02086</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDM2"/>
    <dbReference type="STRING" id="86049.A0A1C1CDM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02086"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01312"/>
    <dbReference type="eggNOG" id="KOG3076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000009">
        <property type="entry name" value="Phosphoribosylglycinamide formyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="21"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT46582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="249" mass="27394" checksum="4D1BFECAF90E8AE8" modified="2016-11-02" version="1">MSSKPVSTDQSRKWSASTSFNLTVLISGSGTNLQALIDACGQAPPSKERSASRRPLPNARIGHVISNRKEAKGLDRAQEAGIFTTYHNLVQYKKKFPDTEAGVKAARNQYDADLAQKILTHIPCPDLVVCAGWMHILSPGFINALASAHVPIINLHPALPGQFDGANAIGRAYEAFQRGEISKTGVMVHYVVDQVDRGAPILVREVEIKSGETQEELEERIHQTEWSLIVEATGKVLADLEEKRRRESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDM3</accession>
    <name>A0A1C1CDM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_02017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDM3"/>
    <dbReference type="STRING" id="86049.A0A1C1CDM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02017"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01350"/>
    <dbReference type="eggNOG" id="ENOG502QRB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2327445at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT46623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="359" mass="39634" checksum="021195C100B72EF5" modified="2016-11-02" version="1">MRVFGRSKSKQPHTEDLSSNKEINAERSGYSKAPPTGLRVFTITIYTLATVFLILVLIGNINNNAVIRSTYFLRIELADIIPASVPYAVFINSIAQSIGLHDFYQVGLWNFCEGYNGQGITHCSPTETLYWFNPVEIILNELLAGASIKLPSDVVDVLDLVRLASAWMFACFIVGVCLTFLCVFFTPMGFSKHPRWQHRTRRIFLRQLPITVLSFGALLLTAAASVIATVMFVIFRNQFQGAADLNIHARLGQPMFAFMWIATGLNLVGFLIQVGTCCGVCCCTGRRKAERRSQRQSHLDVDGSGREGGAGGEEEKAGQHNGISSSTTGKTRQDSSMRSSTTGTRTPTPGRFASQFRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDV4</accession>
    <name>A0A1C1CDV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02124"/>
    <dbReference type="OrthoDB" id="10436911at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="133" mass="14736" checksum="0930D95E6667BCE6" modified="2016-11-02" version="1">MAFNATTMPELSAPETPAQLDYPMQHYLASPPRNDPYVPGAARRNRLTDLIATLDIHLTALSVFIRNYSRHRETDVPGAKAHPRSVVDSVCGGHSQPSSHHNDGKAFPTHFFTLHPIARTILGKTQSRSLTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE25</accession>
    <name>A0A1C1CE25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE25"/>
    <dbReference type="STRING" id="86049.A0A1C1CE25"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02166"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01418"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="120" mass="13450" checksum="2C2630259AF704FB" modified="2016-11-02" version="1">MEEFDCFKKGTRLQQRLLVMGGEASMGRDGILEASWNGVSAEPLETVIVPKSGHWIDNENPQFVAERVAQRIDQLDQRIQEVEFGWLDANYKDRIQAVEAAVKRANTGPAVGIHQPGTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEA4</accession>
    <name>A0A1C1CEA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADP(+)-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_01998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEA4"/>
    <dbReference type="STRING" id="86049.A0A1C1CEA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01998"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01504"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF37">
        <property type="entry name" value="CLAVALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="328" mass="35513" checksum="FE1B2E46F48F8E11" modified="2016-11-02" version="1">MSSSTPTSPRPTPPTDPAALSFTSQTHDTSYPFIDPLRSPPTGLRVLVTGASKGIGRQTALSFARSGASAIALLARSDLDGVASEVAHAARHAGHAGPGPKILKLQTSTTDAAGVERAIATVEREFGSLDVVVNNASRMEVWRSLADADVHDWWDTWEVNLKGTFLVTRATLPLVLKSEKGVKTMVVVTSAGGFSAAEIETDTDIDADADVLAYTVNSPSCSAYQGSKTAQIRFNDFLMREYGEQGLIAYAVHPGGVKTDVASVMPEWMHHVLTAEADLPADTLVWLTRERREWLAGRYVNAPWDMQELESRKDEIVEKDLLKLKLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEI8</accession>
    <name>A0A1C1CEI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEI8"/>
    <dbReference type="STRING" id="86049.A0A1C1CEI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02198"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="73" mass="7505" checksum="8881EE3D39CDE7AB" modified="2016-11-02" version="1">MLALSSPISSLHPTYSSGLAPGVRFALDLTDNGGAGMSGKDDFLFSGPQDTATLRPPADASAPFGFPRQVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEL0</accession>
    <name>A0A1C1CEL0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEL0"/>
    <dbReference type="STRING" id="86049.A0A1C1CEL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02404"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02511"/>
    <dbReference type="eggNOG" id="ENOG502QRDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="132"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="514" mass="55130" checksum="A895CBDB9DF8E25F" modified="2016-11-02" version="1">MTRHRVLPTRSSRQSTSGIINTGSELEHFSPGRDQRSQDDVSPNHEPSRASSRPREQLPPRHASNRSSIPASLADHRPGNTHLINATLLIPGRGEPLHNYSVVLQDGVIMAIQPTSALPPPFKKIPTTDVPVLMPGLWDCHVHFLGSKTFNFAEIATQHPALAGARIAKNLHDVLMSGFTSVRELAGYGLDVSKAIAEGSLVGPNIYSSGAAISQTAGHGDVFDLPSGFVDSMFGVRDTQANALAPGTGPMIIADGVDECRRAVRLVIRRGATCIKVFASGGVLSIADDPLRQQFSLAELQTIVAEAERNGRVVAAHVHGKAGIMAAVMAGVHTIEHGTYMDEECIEEMKQRGIVYVPTRTIVKVGVDHPELMSPESYRKMLITARHHKEAYRLAVRSGVKIALGTDLGISAPTDHPLAHGRSGGELSYAVSDGGMTPLQAIEAATAMGPETLGDLGMKPKSGVIEVGYDADMIALKENPLQNMDLFKGPENITHVWKGGRLFKSPQIKSESPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CET5</accession>
    <name>A0A1C1CET5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PEX7</name>
        <name evidence="10" type="ORF">CLCR_02506</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CET5"/>
    <dbReference type="STRING" id="86049.A0A1C1CET5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02506"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02386"/>
    <dbReference type="eggNOG" id="KOG0277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062137">
        <property type="term" value="C:cargo receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="100"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT47034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="341" mass="37666" checksum="51CAB8F575AE9C8C" modified="2016-11-02" version="1">MLEFRTQGFQGYSVKYSPFFDNRIAVAAAANYGLVGNGRLYVLELTSHGIVPLKVYPTQDALYDVTHSEAHSFHLLTSSGDGALRLYDTSLAPEFPIAKFEEHSREAFSCSWNLTSKATFASSSWDGTVKIWNPERQQSLLTLPTHSCTYSVQWNPHNDGMLSAVCSDSHLRVWDLRTPASASNHLILQIPIHAAPLAAGAGIGKIQPTFPPAEALTHDWNKYRGTVVATGGVDRIIRTFDIRQPKGPLQLLQGHGYAVRKVAWSPHLPDLLLSASYDMTCRVWTDGGEQGGPARELGSMGRHTEFVTGVDWCLFGSEGWAASCGWDERLCVWDVRTVMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF29</accession>
    <name>A0A1C1CF29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF29"/>
    <dbReference type="STRING" id="86049.A0A1C1CF29"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02512"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02306"/>
    <dbReference type="eggNOG" id="KOG3299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="514070at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="359" mass="39023" checksum="BB6004905D8AC46D" modified="2016-11-02" version="1">MAAAAEVQALLRFLTKDARIPLAEAMPKINALRKQQLNTPENIANANEADLRSVFADEKVLKQVANAAKRVSNPKKRAASAQSSSPSSKRARSELEPADDEALLVPPQTDIPLEELEHVIIETNRAPLFLAFTMAVLAYTHPEQPLSSRWSLAQGVVSAGAQSKAKYLGLTSGPTAEEDGWAQGQPKVMIMGREIAVMRRHVPVDVDGEATTPGDAFWALDLEALRKSNGPLIAGKDVKRSSGPPIHKAAAPRNYLLKSMMIIDPDPTLSGETTEGNGATAKKKSTQEVVKKKEDAAAMMLKAIDAVCKSWASVLTAEQLDQRAQTWYTRVRPDVEQGQAGWGQRGQVRIADILKLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFT5</accession>
    <name>A0A1C1CFT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFT5"/>
    <dbReference type="STRING" id="86049.A0A1C1CFT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02503"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02112"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="336" mass="37230" checksum="2A48643702E9A07C" modified="2016-11-02" version="1">MFYKLRAFWSQSFGLPAPPLTEKNLPDQTGKVYLITGSNAGVGYHVASILYGHNAKVYVAARTESKALAAIEAIKQEYPKSHGKLEYLHLNLSDLTKIKASAEDFLSREDKLHWLDNNAGVMVPPKGSKGSQGMDLTYQTNILGPFLFTKLLLPILKRTAEQEPKGTVRVSWAGSLAVELQSPKGGLVWKKGKDGEDTLDDKGDNQLAYGVSKAANYFFATEFGKRFGARDGVLHNCYNPGNLASELQRHTAEQYGTIAARLLQILLYPAIYGAYTEIFSGLAPELTLEKDQGRYIIPWGRRASSMRADISHEATKEDGQASKLFEWCEKVTKEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFY6</accession>
    <name>A0A1C1CFY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_03345</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFY6"/>
    <dbReference type="STRING" id="86049.A0A1C1CFY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03345"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01978"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000606">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000758">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="187"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="359"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="455"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="562"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT47398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="695" mass="74664" checksum="5F84EC9C16BD9790" modified="2016-11-02" version="1">MAAISSLVLSDNIPPKDGMEDLDSPTTPRPGRYGPSSTNESNMTLIDNALPSRESPSTNSQPSSHDGQNGNGAQHHAVERRDSEEAISSTMDMDDDDEGAPGSDNDGESGEADPASRKKKGQRFFCTGYPPCNLSFTRSEHLARHIRKHTGERPFQCHCNRRFSRLDNLRQHAQTVHVNEEIPTDSLAATGTRFQRQIRTDRVRPTGRPRTGTGGSTGGHSRGHSRNLSASSIGSTSSNYSVVTEAKRRPPPLLMASDNAGRPSLGIEPPHTPPAQYRGYNPSSPSGLSTPTSANFSATPGSPGFLSSVASPVSGNARLGGFYGSRPQARRLSVPSGPHPYQHQYPAGYAVGYMNQMGPPSSHASSNSSVFASPTSASFPLGAGQQTPPGEDWRRRTWHASTYPAGNYNYGRPATSGLTYSQTPDAPQPAHAQHATAAAAQAPRLPGIESFDHVQHRSYTPPRRQPSPMQIDPSLSSAPPGTDPRARQGHVSWDGQRPSQYPELDDRAQAVGSWGQQTLNEIQNVGMRYNEPARHADMGPPASMMAAQPHQHMAREALDVQSLGKRTKRKAWYGGPTPARTSPEDSSSSDGVPTPGMTAVEVHPMIMPSSGYMEPQHGHLPPDTHQNVSDRPEFMLSCRDAKVTLLQACLVPAPFIEPGHHQHPMSFGGRSGHGGEMNRLEALVAVATSGENSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG11</accession>
    <name>A0A1C1CG11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anucleate primary sterigmata protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">apsB</name>
        <name evidence="7" type="ORF">CLCR_03248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG11"/>
    <dbReference type="STRING" id="86049.A0A1C1CG11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03248"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01929"/>
    <dbReference type="eggNOG" id="ENOG502QU0H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024545">
        <property type="entry name" value="Mto1-like_Mto2p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12808">
        <property type="entry name" value="Mto2_bdg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="442"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Mto1-like Mto2p-binding" evidence="6">
        <location>
            <begin position="1274"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="domain" description="Mto1-like Mto2p-binding" evidence="6">
        <location>
            <begin position="1470"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="513"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="724"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="964"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1345"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1400"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1501"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="605"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1140"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1221"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="964"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1434"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1447"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1501"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1528"/>
            <end position="1539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT47454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1571" mass="176073" checksum="8C5A04E319DB4DFB" modified="2016-11-02" version="1">MSSSILSDRPRTERRSSRVPGGFDQEEDDDDVASVESGHDDSHHTPDKDEPSSLLPAFRDPSSLLQPIDEHTNLDLPANHTFDESEMNKKLQDHESSFLPDHSPLVERDSQTTGADDTHLFGVVNDNVAVRKKPLPIQISYPAEDTENYVEARPVPSPKTPPGAYKTPAPEQQEFRNTRGSGRSTPQPTSTSALESMSSSPTAAAAARTLSRVQSLATMGGYETANETADRTRSGKNSTNVEGDNDATPRKNETQYLEVPDAADGVQEGAENKPKHRRPGYLHKRSSQARLSYDSMASSNTDASDATIGADFALQSGGALPDSTDRRKARNTISRQASLGSMMSGISGMSDDEPRSQRQVSTSDLGTLQEESPNSNKAGGYNTPRASVYNFNMPSDTVIANNVRDLEVPGTFARQYRQERSMSPEKSNTIIGLTPGPKRGLTLKEHRSTVEKLGKENFDLKMKIHFLDQALQKRSEDGIKEMITENVQLKSDRLRLEKDNHNLRKQVRDLQKKLEETSGARDSPNADQGYATDEERSPTAEEEVLYLRERVEVNEIEIEKLRQENIAKETEKRRLAEMVKSLGDTRAAASDVGSREERDMWKDMLEAETIAREQSEEDNKRLREEIAKLRNDTFASGKSGSRKIKIGGSVVSRSSSVEATTAKDAEIDRLRHEVSELQKMIGAQASTLTSRNKEKERLYQEIEDLKLGRMGGLRSVAGDSILDRSASRARSHSRASNGTRMSRLSDQERETLETRINELRDEVSQLKLENQDLQSQFDEALAELDAVDAQAQADADQFNEELALLTQERDNALRDAEEQDHAFQQLKAEAQEEIDGLGDELDAKVKECSELEEELKAQVENVKALQAEMRSAAEGLVRLEDDAQQNLARYQSVKGELDDANRELESLEKSLSEAETKVQRLTVQQESSHNEIAFLREEQDADKIKIGDLESLLKKVHLNLESERDKSRELERRINEERTQRDAVASQEKQEVQRVINDLNREASGAKDELRKVRKALSVRDIEAKSYQERLSELEESLRNIIGDPNSSRSSLISAVTKMRRELDQTTMDLQSVRARLEQTETLLQDRDALLESTSHECRKLADAYEREKAGRRQDKLDFEKTYKGHNSTTRALTSASARIAELEGLRQTDRKRMTQMENQLKEQLSERNQILLNLWKRLSAMCGPDWAHNNSLINGNLPSQEVIGNMLFWPGFSRNLLLAAKQVEGTLSTFRDKIKRVERELYKEYQALEQTLEVRTRKLERIEESWEQMKIKMSEMETRMDHAPRTPKSTRTPEISKLKGENRLLKAELQLLQQQQAHHNLHHRRDRNESRASGYSASIMSNEAPGQVDGAVNGSAGVPPRSSSMRRSRGLELQRHHSTGIVEHLASMGGDVGSLRSNSISSRHSGYTQPMDRGGLMIPAGPFNAPANGNFSLPPPPREAPPAPPSTASGSDIASITAGSGGGGQGQEKWIHRLRELERRLKAEREARLLDRSGARKRLEERDAVNEELRRELERERVRKGDFDGAGPPPLQLPPAPPGYNEADHQHHGMTPAELEEQAPGPNIGVPRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG39</accession>
    <name>A0A1C1CG39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Btz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CLCR_03342</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG39"/>
    <dbReference type="STRING" id="86049.A0A1C1CG39"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03342"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01914"/>
    <dbReference type="eggNOG" id="ENOG502QUZZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5413466at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018545">
        <property type="entry name" value="Btz_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044796">
        <property type="entry name" value="MLN51_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46837">
        <property type="entry name" value="PROTEIN MLN51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46837:SF5">
        <property type="entry name" value="PROTEIN MLN51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09405">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01044">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Btz" evidence="14">
        <location>
            <begin position="127"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT47469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="685" mass="73907" checksum="771D5163F7DAFC45" modified="2016-11-02" version="1">MPALRRKDLLASRRRRRQDEGEEEESVLGDFEDDSLSEGSAVSNGEDEVEFEGSESSGDERDPAQTTAATTQTSAGQGQQKTPNEPVEDATRAHDDAFKPAAETQAMQHGVNQGQQAQEAEQLQFDNLPTSAEAAAAPAETVPPKAPRNETPAQRARREHQEYIRQRNADPAFVPTRGGFFLHDDRNSSSIAPNARPLGRGRGRGHGHPMTTGRAPGFNEPTDKPWAHDLHDEHENEAKPERNRSKPTHVPNEVAKEPSKPTSSTSAPNRSFSFTTVLGNVNVQVSLPGMAQKVVVPNVVKKHHTLLPQHRPPLRRDKPVRVSIPDAAPRYIFPSTDRSFIFIPRALRPNQQGYARGRGRGSFNASRRPSIYGGGYTPSVAMSRKSSLGASTMRDGIRSPTDSVMSRHVPAVMDGTRPVVRMPSAGPSPALMHVPRLNGQNAMPINHIPAVQLPFPAMYGGHSTTIPMHQPRPQKAVSLADIESPASFPFKAPQQQQEQPFHQQVPAHYGNQYPDEKVGAPPVQPTASAMASATPLSQIPEGAVFAPGFQPYPVMGGPAYFGAPYNNGPAFYPSMADTSSFGPPMGGPALAPNFIPGSQSHPVSYMPPVGPSEGAVAGSMMAHETNGMVYYYNPTMFAPGTQPGMQQFPMAPNGNMMPLADGVSGQAPFYYTSVPTAMFYPTQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGT5</accession>
    <name>A0A1C1CGT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diaminopropionate ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dpaL</name>
        <name evidence="2" type="ORF">CLCR_03572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGT5"/>
    <dbReference type="STRING" id="86049.A0A1C1CGT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03572"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04621"/>
    <dbReference type="eggNOG" id="KOG1250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937:SF1">
        <property type="entry name" value="DIAMINOPROPIONATE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="1">
        <location>
            <begin position="34"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="381" mass="40415" checksum="1B5BBBF2F6084B05" modified="2016-11-02" version="1">MSSPTLYANPSAKSWTYSYETDISLARAFHKRLPGYEQTPLVPLHDLAAEMGFDAVFVKDESSRLGLPAFKILGASWGTFRAIADQTGLSLDASLRDVSEAAKKAGTILFAATEGNHGRAVARMGKILEIPTRVFLSRFANGETRRKIESEGAQVTVIQGSYDDAVAAAFAESARLSTGLLIQDNAFEGYERIPAWIVEGYSTLLFEIEEQLEARGLRATMVVTPIGVGSLGHAVVAYCKSGGRQIEVLTVEPETAACLHHNLSAGEWSTIDTSATIMNGMNCGTVSPISWPVLSKGVDASITVSDLECHESVQYLQSRGINAGPCGAATLAAIKKAGSTALISGDTPSNPVVVLLNTEGARAYPLPHSDLVSKASDRPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH37</accession>
    <name>A0A1C1CH37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_03639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH37"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03639"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04568"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="89"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="293" mass="31013" checksum="D8337E731495F7D5" modified="2016-11-02" version="1">MSCVVTYFFRRRSLALGIAATGSSIGGVIFPVMVEKLIPQVGFGWTMRICAFMVLVLMVMGNLTLKSRIPPMPKPVRAMDIVKPFLEGDFALLALGSFLTFLGESLQYHRSGHAVAHHSSGLFLPFTFIILAAQERGVPDGLAKYLVAVLNAASTFGRTIPPFLADRLGRFTVFLAMGLLSCVIVLALWLPSSGTAATIVFCLVFGFSSGAVASILPSLVATISHISQIGVRTGCNFSVVAVAVLIGSPIGGQLIQNDGYKSMQGFSGALLGGGLIVFTVLWVRLGGLTGKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH61</accession>
    <name>A0A1C1CH61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH61"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03564"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04504"/>
    <dbReference type="eggNOG" id="ENOG502RMEJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3360610at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07267">
        <property type="entry name" value="THT_Oxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="10"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="163"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="356" mass="39384" checksum="F181A74F1F8A6A62" modified="2016-11-02" version="1">MAIKQVRVVRLAHVVYQHPDLERALSFLFDFGFVEAQRTPERVYLRGYGIQPFIYVAEKSPDAKRHFKGAYWVVDTLADLEAAAAHPTASAVQDSDAPGGGKVVTLEDPNGFPVGFVFGQKLRESDGAAPPLEKTDPIPNLALEKPRKGTFRRFKTGPSATHKLGHYGFIVPASKFESTLSFYKSLINIKPTDAVYNPATGKDETCFCHIDLGQQYTDHHSFFVAAGPEERPPFIHHSSYEVNDFDTQTLGHDWLRSKGWTNCWGIGRHVLGSQIFDYWFDGSGNIVEHYSDSDQVNEDTPFGREPAAPDSLHVWGPNIPLAFMSGKIEDAGKELPVPPDALEATPAQYDLPAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHC6</accession>
    <name>A0A1C1CHC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uroporphyrinogen-III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHC6"/>
    <dbReference type="STRING" id="86049.A0A1C1CHC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03499"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04429"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="2">
        <location>
            <begin position="275"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="452" mass="49299" checksum="8E61D72B34A8E2CD" modified="2016-11-02" version="1">MATPPPSPTTIPVLLLKTRSQPHDAYEEYFSDFRRGGGGGNATNNGAEATPLVFLPEFVPVLEHRPNSENLARLVKLLSEGRLSEQYGGMIFTSQRAVEAWADVVKRVEGETQTDTDTDTDTSTGTETQPPQTSAATSQDTTTGSGVADDDTGPRDSKETGAGAGETGESAPRPLIDDDFMFPLYTVGPATSRALNSLIVESAATVPSSQFARLRPAVFGEHTGNGDKLAQYILSHYNTLHSHRVYTFYEAPRLPFTPLLGSARGERVDKDDARLRKKPLLFLVGEQRRDIIPKTLTDKDGRLPSAERIPVDELEVYITAVVESVEDDLRDRLSSFFDAAGRNVPLVVVVVVFSPQGCESMLRALGFLDDDKNLTPLASRRWTGEQSDDPTSKDSARSESQHRRYIVVTIGPTTRDHLKARYGFDADVCAAKPSPEGVGAGLVEFLTQHHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHH1</accession>
    <name>A0A1C1CHH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_04004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHH1"/>
    <dbReference type="STRING" id="86049.A0A1C1CHH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04004"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08133"/>
    <dbReference type="eggNOG" id="KOG0706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000013">
        <property type="entry name" value="Putative Arf GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="9"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="534" mass="56362" checksum="4FCAE1F4447144D4" modified="2016-11-02" version="1">MSATKTQSQRIFEKLKAKPANKVCFDCGQKNPTWSSVPFGVYLCLDCSSNHRNLGVHISFVRSTNLDVWQWAQLRTMKVGGNESATKFFQMNGGSAALASKDAKVKYTSNAANKYKEELKRRAERDAQEYPDEVVITDDALSTPGADGTSTPAGEPADDFFSSWDKPTIKRPSNPPSRSATPPVVSRTASPFLSTGNANGAQSRPKSPSPLASSTGDGEAALAAPTAIRTTSSSAIRKTGTLGGAGAKRTNVLGGKKPAQKLGAKKVVGEEIDFEAAEKAAKAEAERIEKLGYDPEAEKTEELAKNKSSNFGSASASPKESPAPINTSARSASNPSHTRSPSEVERLGMGMNRLGFGQIGPAKAAAGASSAAAPKKLGFGAVGPMKPAAADGESSQNNLRSPFLPPSLLYSIDIMPPADDGEQYARQKFGTQKSISSDEFFGRAAFDPSAQAEAKSRLQNFDGATSISSNAYFGRPEDDLTGLEDGNYGDIETVAKDFVRRLGLTAGDDLENLINVAGEGGRKLRGAVARYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHH8</accession>
    <name>A0A1C1CHH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_03608</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHH8"/>
    <dbReference type="STRING" id="86049.A0A1C1CHH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03608"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04462"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="5">
        <location>
            <begin position="16"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="72"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="260"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="145"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT47891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="341" mass="35929" checksum="7DDD9A5229C3AA81" modified="2016-11-02" version="1">MPPALHPLHAQVSSALQSRHHIAVDAQWLNDFLTSRGPNPPPLPALISTAHFRILASDITTSISSNSAATFPEDASDVTIRERRLQDHVIVQVLDVHDVGSSKFSQIEAIERVERGEEIRGREVIRSVRVDHDGENEDEDGAGVATRTRTSTSTSTSTGTSTTTNSNNNPATARTSTTPPTKLKLTSGPHKLVVQDAKGTRMFALEVDKVPKLGVTVSAGAKLPPPPPPPPPPPPPPPPHAGTGTETSLGGGVVSADDPGMFIGCKLLLRPGTVVRRGMIMLAPENCLVMGGKVEAWDRKWREGRKKRLVALLADENSDSSSSANANANANANANGAAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHI4</accession>
    <name>A0A1C1CHI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein VTS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein vts1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">vts1</name>
        <name evidence="15" type="ORF">CLCR_03974</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in post-transcriptional regulation through transcript degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHI4"/>
    <dbReference type="STRING" id="86049.A0A1C1CHI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03974"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08160"/>
    <dbReference type="eggNOG" id="KOG3791">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000033">
        <property type="entry name" value="Protein vts1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="552"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="228"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="522"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT47994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="616" mass="66578" checksum="97C8CA27ED47EF89" modified="2016-11-02" version="1">MASNIIGNRNSTPEASKTSLRPPSSRTIGTSGPHNQPVRSSADMSFTSPLSARSIRPASEVLYNQQSQQGSMDDSSKLGEQWIQDIEQYETMLEEMAAATLDQDFKDELSAIEQWFRVLSEAERTAATYALIQQTTQMQQRFFAQVLNQMSKSHPISGVLSPANFGEKDAMSSRLSDAMSKLNVEDRRTSLTRPPVSPAGNKRNSGLDQSTIHAMFPDAVAAIQQQKAEYAQHTGNQPPSNRNSTVVGDRSSLVAPTISAPRESKTDAMSWRQGAGESHQPPISRPKSSSGQQSLQQPMGQFSQPQSSGALRSPRPLGHAGGNIQSTTLTAPDPASSEYPLLSPYNVGNQSWASMSNTPMVPNFSQAQSHSEMVASATAMKLAALSTVNNRIALDDVKKYRRARSNEPQPPTQPPLTPGLTASGIPGINTIMVNDHGQILNAQQVAAIQAQQIVAAQGRRSRPNSPGLPLQTPLGQTAFASPQHNGFLAAYDGTPIMMGAGMPGMVPQTGIFGASGEGYLSDHSEINRGRSPRGRRGSSKPPEDPTDVNLLKDIPAWLRSLRLHKYTENLKDLSWEELIQLDDKGLDARGVNALGARNKMLKVFEQVKEAQAEGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHY4</accession>
    <name>A0A1C1CHY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04298"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08286"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="244" mass="27006" checksum="25B31CA48E1F4491" modified="2016-11-02" version="1">MDNDASPKMPPVKEDIKVAVMGLGPGGLALAKNMAKVHPVCAFDYCWEGPHDPVKNIWWSDNPYDLSFATHFIIADSCSRRYTGREFEAWVTDILWARSIIRAALVGRESPATIILASVVPEVGLTKKLLGEFHAAGHRLGVAPQPDLDLGDDEILRYIPKLVGGIDRESTRSIGSLYESVLGRREVGPPGKLEFAEAATAHGFLMDIELFARIWKLMGDYIDRAEEEHGDEWSDEEDSDKKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI59</accession>
    <name>A0A1C1CI59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HhH-GPD family base excision DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI59"/>
    <dbReference type="STRING" id="86049.A0A1C1CI59"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04179"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08357"/>
    <dbReference type="eggNOG" id="ENOG502QRUG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5607at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000702">
        <property type="term" value="F:oxidized base lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203:SF1">
        <property type="entry name" value="HYPOTHETICAL BASE EXCISION DNA REPAIR PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="2">
        <location>
            <begin position="177"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="390" mass="42803" checksum="62C98FD22480E816" modified="2016-11-02" version="1">MSRATRVASATQRATRSSTSTRAGAAAVKKQQPEEAAIKQEQQTPEKASRAQAKRALSAIEKETPKRKRVKKEEEEDSPLQSASPSSSYPSKKSPSSTRSTPSTLKDKKLKSYAQFANVSPFPDFLHPTPEECKLAHRILSSLHGPRTRPTQLIASTDRAGCGDSPSVLDALVRTILSQNTSDVNSSRAKKSMDKIYGRSDKWDAIVAGGQAKLQDAIKCGGLSAVKSKVILSILNQVYEKYGLYSLDHLHQASSEDAMAEMLSFHGVGPKTASCVLLFCLQRESFAVDTHVWRITGLLGWRPKTATRDETHAHLDVMIPDEDKYGLHILLVTHGKKCDECKAGGKNLGKCELRKAFRQKKMEGEAGEDVKQEEIELVKQEHIGTGPWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI75</accession>
    <name>A0A1C1CI75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI75"/>
    <dbReference type="STRING" id="86049.A0A1C1CI75"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04051"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08358"/>
    <dbReference type="OrthoDB" id="2951834at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="519" mass="54645" checksum="28741A79F221B86E" modified="2016-11-02" version="1">MATSSADDGQANSTSQLDAAPVSPHGPAHGSFFDLAVELRLKVYQQLFCFAEPIKLIVDGAGLFKHERTGPGADKIPVHVFRVNKKAYLEASPVLFKCNIFALDLSTLRAGLARPEPMYKHVESLEVCWTVGPFWGYVQTVKAAGEKMPALRKLELKFEQPRALLAASLEFCSAIMACAPLIGSPELRLCALLSGSEWMNGADDQYDLPIRTALARAGSTLRDIQPHPNFHVSPLTRSILPELHLIQLTGKITPSLLHKIEQHVCEMGECTWVRTGEEDSQRHADGTNTGQRIHMRWGKSDSPVVRPGVPEVNMLQFYPELSKSEKKKIQEFFASFQQVVGGTSSVGFGNTTSRQPTTGGTDQAAVRPPEAHSDADRQTRCVGNGVSAQEDVNTATHSHAHNATSATSAQTGPATPPIAHTPEENLQALQALPFSNYHSDLVSEFVHPDMKDDDDAAWAAVFAAIARDFGIANTGADAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGADTESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIM3</accession>
    <name>A0A1C1CIM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidyl synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIM3"/>
    <dbReference type="STRING" id="86049.A0A1C1CIM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04094"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08509"/>
    <dbReference type="eggNOG" id="KOG1618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="50935" checksum="D37F387139BDF3D1" modified="2016-11-02" version="1">MESDKPSDQDSGMLYPTAAKASHAGLRRVSSQSAKREDLFSGPTLVGPPDRLGSRSGASEMALAMEMAKHHLAESSPTSTPPVSGPVTPNDIGLATTDKYAFAFDIDGVLIKGGKVIPEAIEAMRVLNGENEFGIKVPYIFVTNGGGKTEEERCIQLSNQLQMEVSPGQFICGHTPMREMAEKYETVLVVGGEGEKCREVAKGYGFKDVITPGDIIKDNEDTTPFRKLTEEERQLSHGRNYGNINIEAVFVFADSRDWAGDSQIILDLCMSKNGRLGTRSETFDEGPPVFFSHNDVVWATSHTYSRIGMGALRASLEAMFRAITGKELKTVAFGKPQVGTFQFATRLLQQWRKDTHGINRPPETVYFVGDTPESDIRGTNEFDQSGQSEASWYSILVRTGVFQEGTRPRYMPKMTVDNVLEAVKHGMKREFDKAIKDLTIGGGAPQLANAITEDDDEGEEATNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ46</accession>
    <name>A0A1C1CJ46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) endonuclease 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CLCR_03910</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ46"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ46"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03910"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10305"/>
    <dbReference type="eggNOG" id="KOG1294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="391817at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09088">
        <property type="entry name" value="Ape2-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000079">
        <property type="entry name" value="DNA-(apurinic or apyrimidinic site) lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="14">
        <location>
            <begin position="652"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="401"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="11">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT48538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="716" mass="80443" checksum="CB710EBB332FD5A9" modified="2016-11-02" version="1">MVLRVTTWNVNGMRTLLEHQPWKSAKSMENMFDILEADIVIFQEAKVQRKDLPDDMVLLDGWESYWSFPKEKKGYSGVVVYTRNAKCTPIRVEEGFTGCLTVPGTSVPYRELAKEQQIGGYPDAAALSDHRYKLESLDSEGRCVLVEFQAFVLIATYFPAERDESRTHYRLNFLQVLEVRIRNLVKMGKRVVLAGDLNISREEIDTAHIGKAMLQPQFDPVEWISTPPRRWLNHLLVGGRIYGPRDTGREPILWDVCRSFHEGRVGMYTCWETRINARPGNYGARIDYIICSHDMREWFSASNIQEGLMGSDHCPVYADLKDTVVVDGVERHILDLVNPPGMFVRGIRQVGRRAERALPLSGRLLGEFRNRQSIKDMLTRQPVPPKVENSLQVLAPRTTGELPPPAFHRQTLAPRYPQQSPTPDIDSILRQLPPYSPRERIPRPFDGQPGAAQDDLQLVQTDMPSAPSHDDAWCSGSSCGKRPGTTVGESRPAKRRLGPGQTILKDLGRPTSKGPGQKPSKGLRRTSSTKVKDQQTLPDFFSRATLPSEPGAKVKTGPRREDDQRLLSLPLPQRSERDDVMTVATAADAQAGPTSPQQSATTRIWISNLLNHEDGHVKAKTEVAPKPPAKPTAAETKDSWRKLLAPPVAPLCDHNEPCKKDTVKKPHLNAGRMFWVCARPVGPSGKNESGTVWSCKTFFWHSDWETQSRQTGTRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ79</accession>
    <name>A0A1C1CJ79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkyl transferase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_04176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ79"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ79"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04176"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10280"/>
    <dbReference type="eggNOG" id="KOG1602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT48568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="394" mass="44641" checksum="9A2830DDD42A5B7D" modified="2016-11-02" version="1">MASRSAHRLTSSLRKWLLSSPPAEWALNQLRELLIGALRQGPVPKHVAFVMDGNRRFARNHRIETVEGHNLGFEALAKILEVCYKSGVHTVTIYAFSIENFKRSKYEVDALMAMAKIKLKQLVQHGDLLDRYGARIRILGQRELIKPDVLEAVDKAVETTSQNQGKCVLNVCFPYTSREEITTAVKCVVEQWSRPLPEEHPAGQKDRQSPFREDRIAQAIRSEQVSQHSTTTTTHLSPPGFRSPSSSTTSLSSYSPDLASDHDTESVSTSTTLHHDDAPAPFSHTSSTTQKPRYPPPDSITAETITSNTYTSSCPPIDLLIRTSGVSRLSDFMLWQCHEDTEIVFLDVLWPEFDLWSFLPVLWEWQWRRRREQKMEHETKTTRPEPGAGKVHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ86</accession>
    <name>A0A1C1CJ86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ86"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11293"/>
    <dbReference type="OrthoDB" id="4138072at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="205" mass="21575" checksum="98891A5FF26CD6C6" modified="2016-11-02" version="1">MAAIVSSLGAGTTKLLGQGASDPSQLPSGLQGIQAGTTGLFGHGAFDPSQFPSEVQEMEADHNSSIGDSEYEALMQLLKHLTESAADVSHDPNLEHGMEELAHALQAIETSDGTDFNEELITTAVHTLQSEGHCENIFAFLEQLHHDGVDFGDDELHTIIANISGLFTHAAGQAEQGGGAQPSLMGKVSELFHMQDGFKTAGGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJG2</accession>
    <name>A0A1C1CJG2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TAM domain methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJG2"/>
    <dbReference type="STRING" id="86049.A0A1C1CJG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04118"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10244"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="338" mass="38105" checksum="900B2908958AF3BA" modified="2016-11-02" version="1">METPSTPDSVDAALQEVSELTRDLSLGGSVEDESPPTMPPKKYWREEYGRHYSVLGRYESMFPSDEDENHHFFRLQSLLTRVLRWQLFRCPASLVTANVLDMGTGTGQWALNVGRKEPSCKVTGVDIAPVEAGSNRANVKFEVQDLESDWPRRRAYSFIFGRQLGGSIVDWARLIRRCYDNLENGGWIEFHELDSNFYVMPNSAPGRKVMEMSQLLSLGLSNLGRRLDVADYIRELLQQQGFENITHDRVAVPIGMWPAPAPPNHNAIDSMRNVGLARITELEFGIEGLTLKPFCKGLGWTPAQVHPFIADVTREVVVGGTKMASTLNVIYAQKNVWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJL6</accession>
    <name>A0A1C1CJL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_05067</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJL6"/>
    <dbReference type="STRING" id="86049.A0A1C1CJL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05067"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03236"/>
    <dbReference type="eggNOG" id="KOG1662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT48656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="224" mass="23851" checksum="E0D17650F7F9F1C7" modified="2016-11-02" version="1">MMSARLMRPAFAAARRTAPRTAIRTYAAPAAADTKPPVPLFGLDGTYANALYTAAAKQGSLDPTAKAISSLLQILKTDAKLPQILLAPMLSDSDKSQIIAELEKHTGGADKSGTVKNFLQALGENNRLGLLEGVCEKFGTLISAAKGELELVVTSAAKLDEKTLRRLETAISKSEYSQGKKLKVVSKVNPDILGGLIVEIGERTIDLSVSSKISRLNKMLTETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKG1</accession>
    <name>A0A1C1CKG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_04734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKG1"/>
    <dbReference type="STRING" id="86049.A0A1C1CKG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04734"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02916"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF59">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="131"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="533" mass="58562" checksum="47AEB3772CD10546" modified="2016-11-02" version="1">MADPQAQAQTQVHSQDHARRSMSRTHTSSENLVLETTNSEYGDLASPDDDAEKEKPEGRLRSSFATGRSNDLNPSLNLQKTVTRRETILSRIRSRPPLGNFNHPLEHQKTTVEDLVDFDGPDDPYRPLNWAMGKKVLTTALYGFTTMSATWGSSAYSPGTEQVARQFHVGTQTSTLGTTLFLFGFGLGPLLWAPLSEVYGRKNAVLPPMFVAAMFSFGSGAAKDIQTVMITRFFAGFFASAPVTNTGGVLADLFPASQRGIAIATYAMAVVLGPVFGPIIGAALVVQRNLGWRWTEYLTGIIQLFFLSLDVIFLDESYPPRLLVYKARRLRHQSGNWALHAKFEEWDVSIQELANKPPSCSTLTIVQFLVRPFQLLTTPICALVALYASFCYGILYMQLGAIPIIFAENRHWKQVPSELPFLAILLGAVTGAAINIFNQILYNRKAGGKVAPELRLPPMMFGSFLFAAGLFVTGWTADPSIHWIAPVIGLYLAGLGFFTIFQAALNYLVDTFQKYAASAVAANTFLRSCFAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKJ3</accession>
    <name>A0A1C1CKJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CLCR_04572</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKJ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CKJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04572"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02879"/>
    <dbReference type="eggNOG" id="ENOG502S359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5396806at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14368">
        <property type="entry name" value="CUE_DEF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041803">
        <property type="entry name" value="DEF1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="17">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="130"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="444"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="594"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="715"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="594"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT49033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="901" mass="94541" checksum="CBA00ED054271642" modified="2016-11-02" version="1">MAEVQSRTGGSRGRGGFRGGRGGFRGTRNTSRSQHKPDNEQENTPPAPLEDQGEVGELLRKYGDRVPLLKEICPGWSDQDLVYALSETDGDVENAFDRISSGKEESHAHFNVLADHSCPGSISQWGEVKKKHAKAKEATPASTETATRSRGRGGFEGRGRGRGAERGARGGRGAKSTSVAHTNGTKSTGDGWDTPATTTVEATGGWDTTTADAAPTNGDTPAHAADDWANEPGKDSLSSLQTEEPKPASSAAPSSVKPGGWAGLFAKPTPAPAPKKAAAPPPAAQPEASFVEAEPEPTIEVPAVETPEPALPPPIEAVEINEDGPSELPSAPHSETGQELTPSKDELTEHNLEKLPDTSHPPESATQVSTVASTLDPLATADSKIAPRVPLSGYHATALKATGGASRSASFTRKVMEQQEAVVMPGNHAMEKAAVQFGKLGLGADDVDVDEDREEPETRTQLPDDSPAAPRASLPPALPEAQQTPVAVQSQPLAEAPSTAQRQAAGLPPAPQQAPEPSPQSSSAYADQYRYGQGQKPYDPFGQQQPQTSQAPAQEPFSNQVPSQPSTATTQPDYAAYYGRDAYNYYGYGHGQDAQRSGSAFGSSAPDNQAHYATSRPQQHALGQQETQGSGNNTPAPGLPAQHTQQQAGHVQQTQGHAYPGYGYPNAYNQQYPQYAGNYMGNMNHRFGANRPMFDDVRRQDSEYYSSQQQYNYGQNHYGNTYKSNLYGQPQQGYSYEHGSSPANVGTFSREAGYGRAGSAQPSEAQQGAAANAGFGGMPDPFGRSSSGFGQPQGLGQQHGAHAEDPAKGSGPSPSMQGGRPGSAVNSGFPAQQGVLPPPSQHSAQQAFGGYPQYGGNVATSHQNTHQNTAYGSYGSNNAFGGYGGYGGARGGWNGSYGSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKR5</accession>
    <name>A0A1C1CKR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 15.0 kDa protein in dhaT-dhaS intergenic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05027"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02889"/>
    <dbReference type="OrthoDB" id="5075159at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052517">
        <property type="entry name" value="GlcG_carb_metab_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34309:SF1">
        <property type="entry name" value="PROTEIN GLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34309">
        <property type="entry name" value="SLR1406 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="159" mass="16644" checksum="BC6432FB3166E21D" modified="2016-11-02" version="1">MSQTVDRKATHGWGSTPSQRHYISHEQAMEVLAAGIKRAKEINVPQNIAVLDPSAWLVGFVRMDNAFLGSIDVSQKKAKSVVFYNGIPSDALKQRSEPGGDLFAIQETNGGTVVFGGGFPIYDAEGFFIGAVGVSGGTVDQDIDVAKAAVEGSGVGTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL05</accession>
    <name>A0A1C1CL05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL05"/>
    <dbReference type="STRING" id="86049.A0A1C1CL05"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05143"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02748"/>
    <dbReference type="eggNOG" id="ENOG502S165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="237" mass="27238" checksum="54981C9F898FBEAB" modified="2016-11-02" version="1">MTRGYEKLDVRGDDHLDSDSNRDEDDSDLGLLRGKWKASKRRSGWLRSILVGLAGVVILASLCAVAYTSIGVHNIQHSLHIKATGTELGDCGSSHTVEEARAKGCVFDPMSWLWVRPECYDAELIDDFMQRTDWSWHTDWHLTPESQVPMDIVFRGDHPQLFTAKKYHAIHCTYMWQKMHKALIEHRPVDSDLTNWHHTHHCEEVLLDDYLHEDSNCTADMICPTLVRATWTSCGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL53</accession>
    <name>A0A1C1CL53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL53"/>
    <dbReference type="STRING" id="86049.A0A1C1CL53"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05021"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02716"/>
    <dbReference type="eggNOG" id="ENOG502QQBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058268">
        <property type="entry name" value="DUF7962"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25907">
        <property type="entry name" value="DUF7962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF7962" evidence="1">
        <location>
            <begin position="117"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="309" mass="34161" checksum="5BB6D0180EB0BFD7" modified="2016-11-02" version="1">MGSVSEPPVVLFDYQFAPNAQKARNLLSMCGIPFKVCEQPFVMPRPVLADLGITYRRIPVNAIGRDLYADNHVFLEAVQSAFPEKAAALAKSPADHAYEAFGYRTFWICLPLVPEKLMSEEFLKDRAELFSVFNRPDYKQLRPSALAEFRQTLDLVEKDFLAQGPWIGGEKCSIADIHASWMIKFVLQTLDVKNEPGFSERDFPKVHAWVNGLPLHTAENDAEKISADEAKQAILSSAYAAKDTGIDSADPTGLQAGVRVVVGTTDDATPGGRPQEGKLVGLSRNEVVIELENGIRMHFPRLGFVVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMP4</accession>
    <name>A0A1C1CMP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">phdK</name>
        <name evidence="6" type="ORF">CLCR_07103</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMP4"/>
    <dbReference type="STRING" id="86049.A0A1C1CMP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07103"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08704"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT49780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="488" mass="52796" checksum="18A5128DD2DC4232" modified="2016-11-02" version="1">MSFPNVEECLPKNWSLFFGGKWQEPQDGEYLEIYSPGDGKAIRKVAFAGAKDTAAAVEAAQEAFPAWRAVPSLERGKKLKKVADILRQHADALALLDAYNTGNPVSMMKADAFFAADHVDMFAGLIPAVQGETTHLDDSTFNYTLREPLGVVARIVASNHPLMFTANRLAAPIAMGNTVVIKLPEQAPLSGLRFAELLDGIFPPGVLNILSGGLDCGKVLSTHPLVRKVTLIGSVPTGKAIQKAAADTLKLTSYELGGKNALIAYPDADLERLTNSIVAGMNFGWCGQSCGSTSRVFLHEALHDEVLDRVRDKIATSFKPGNPIDPKTTMGALVSKAAQDRVLRYVEVGKKDGARLVLGGKVPEGADTKGGYFVEPTIFSGVTQKMRIANEEVFGPILSILKWTDEEQLFKDVNAVEYGLTGAVFTSDIKTMQTAVRRIEAGTVWVNTVGTHFFGMPFGGYKQSGIGRDDCFEELRDMTQCKAVHVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN61</accession>
    <name>A0A1C1CN61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative trna processing endoribonuclease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN61"/>
    <dbReference type="STRING" id="86049.A0A1C1CN61"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06739"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08852"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="103"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="571" mass="64436" checksum="EB5775D0D15D7C37" modified="2016-11-02" version="1">MQQATPPNESVGIRAPKACVPCAVAKVRCETDEGQIICKRDVSRLERKLDGVAAILAASDNVGLARASSGQTPPTIGGYIDQFLQSDDEAHLMLDIFRNELTPHFPFVVISPWVTSSDVRARKPFFFLTVMMITCRHDIPRQGAIAKAIREILSQRMLIKSEQSLDMLQGMLFYLAWYHTHLHLGTQLTNLLHLIMSLMIDLGLNRQTAPRRYAKPQREYFRMDGRGDNVAPRTLEERRTYLGCYCLTVVISMTARDFEPVRYTRYTEECCQLLSEAAEYPTDTYLVHVVRLLYLGDKVNRTFNQQEWDPSPTISVPVGAAVKSMEAELLKLKPSVLLLPPDTLQNVLLLMHYYGVETYLYEIALDEKVEASRYGSFSLTRLSLLFACLQSAKHFFDTFYALPSSTYFDLPYSTWTLVSHLNVVLSKLSLCAVDGWDHDYVSQTLNFHAVLDKLSAKVEEAIQMATTATTTTTSTRSPQENATTPNNNNALPRSVPLIFVTVETKIKEIKAVHDARKADLARRQSQHAPLPADQLQVADELATALPDDFAVMDSLDFFYFGDDALWAQNWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNS8</accession>
    <name>A0A1C1CNS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucan 1,3-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_07177</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNS8"/>
    <dbReference type="STRING" id="86049.A0A1C1CNS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07177"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09063"/>
    <dbReference type="eggNOG" id="ENOG502QPYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990819">
        <property type="term" value="C:mating projection actin fusion focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070879">
        <property type="term" value="P:fungal-type cell wall beta-glucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904541">
        <property type="term" value="P:fungal-type cell wall disassembly involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF8">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650934" evidence="6">
        <location>
            <begin position="19"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="7">
        <location>
            <begin position="88"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="409" mass="45088" checksum="DA2E4F347CA4D8BD" modified="2016-11-02" version="1">MLVVEALLVALSATAVSSAPLAKRQFSYGSTPVRGANIGGWLVLEPWITPSIFKQFDGGVVDEYTLTQQVPNAREILRNHWDSWVSLADFQKLADNGFNSVRIPIGYWAFEKYRGDPYIQGAADYLDKAIDWARQTGLKVWIDLHGAPLSQNGQDNSGLLTSAPGWTSGNTILATLGVIGQISDKYGSADYADVISGIELLNEPRMGALPGGRGATEGYYQAGFETVRSKSQAPVIFQDGFTDPSSWNGFLTGQGTSGAIVDHHEYQMFTNELVALTPEEHVNYVYSSADSWAQGQDKFVIAGEWTAAMTDCAPAINGYGVGARYDGTYSTRNADGSYSTSPYVGSCDTINYIDQWSEYNKTTTRDYIRAQLDVFENQIQGWFFWNFKTEATAEWDLFRLIDAGVWPDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNV6</accession>
    <name>A0A1C1CNV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar protein sorting protein Vps66</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_07301</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNV6"/>
    <dbReference type="STRING" id="86049.A0A1C1CNV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07301"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05797"/>
    <dbReference type="eggNOG" id="KOG2898">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF60">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID:OLEOYL-COA ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40675" checksum="C0E1644629FBAA05" modified="2016-11-02" version="1">MERFSQFRDKGVFFDVDAFHYTDRTLSGSGIAPFLPIPTESAGIALPFHIFLYICRVPLLIVFALSYFVILQWMPLGILGRKASLWCILGIPGIWWIDLQIDGVKKGSLAQNKSKIPQEGSIITSSSASPIDPLYLAAIFDPIFAATYPYTRLVEPISLLTAIYRSFAHPKLEPAYNAKLVGLETLIKQNPERIIAVFPECTTTNGRGILPLSPSLVTIPPRTKVFPVSLRYTPPDVTTPIPHCYLSFLWNLCSKPSHCIRIRIAEAVYNTSKSSSAKESTVAAKVSSSYTTNYFDTLGSDNGVSSDADTLVGSGGEEQEPSMTKDEKAFLDKVAEALARLGRVKRVGLGVKEKIEFIEMWATSRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPJ5</accession>
    <name>A0A1C1CPJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative altered inheritance of mitochondria protein 13, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPJ5"/>
    <dbReference type="STRING" id="86049.A0A1C1CPJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07552"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05597"/>
    <dbReference type="OrthoDB" id="5544375at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="198" mass="22563" checksum="6183260204BCD658" modified="2016-11-02" version="1">MGAGQSKPDQSTKHVFASDTPIQFSQELIDSLQASSETNSTRAKTLELHIQQRVAEELEKIKKHESEALEAIRKKIAEESPSDSSSISPKDLIPGAKNDEEQKRKAQSSQKVQQEIEKLKQQLGQRKTLKELPKEVENACVTTLDGMRDSELTYGIRRQDVISCLRINDRKPLDCWKEVEIFKREVRKLEENYVSSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPP1</accession>
    <name>A0A1C1CPP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative MFS-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_06833</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPP1"/>
    <dbReference type="STRING" id="86049.A0A1C1CPP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06833"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05523"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="112"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="562"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT50484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="588" mass="64204" checksum="2637C7FDE689BCEC" modified="2016-11-02" version="1">MQSTVQGLSHSLASPGPTSSQGQLSDADEKQLDHPAGTGGASPQISLNPGLQDWTKYTFRKRPWRRRVTDFKQIVEAKYRGSGTPGDPFVVQWLDHDPENPKNYSTLSKWLMTFLLAFMTLCVSLASSAYTGAAGLIIPEFHCSHEVFLLGLSLMVAGFALGPLVWAPLSEAVSRRDILLIALGLYIIFTAVCAAAQSITALIILRLLCGTMGSAAFVIPGGQLSDMFEAEQRGMAQAVYAAAPFLGPTLGPMIGGFLSPAAGWRWLFGFLALYAAVLTFFGIIFVPETYAPVLLRRRAKLLSKATGKVYMTRIDIEQPLVLKEVVKRSLARPWALLFREPIVFLLSIYMAVVYGTLYLFFAAFPIVFQQGYGWNAGEEGLAFLSIMVGNLLAVGVIIMDNKRYIRISKAHGGFAPPESRPPPVIFGGVIAIVGLAWFAATADPRIHFIVPVLSGLPFGIGFILIFMCCSNYLVDSYVIYSASVLAGNSILRSTFGAVFPLFATYMYDSLGVHWASAVPGFIALACFPFPIFFYKYGESIRRRCKYSAEAARFLDSLKSDLERQQSKASKAEEVGGGVVERERNDVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPU8</accession>
    <name>A0A1C1CPU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4329 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07609"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05473"/>
    <dbReference type="OrthoDB" id="4145738at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21333" checksum="827559A98C7BEF59" modified="2016-11-02" version="1">MAGVRTVATITLHDLFNSEKFDLKEFRRLLEVGVDWCYRDNLEYRGVIYATADGSKLKNAGPKTDNMESGVNMEEYKKIPAGYTNIVAAYHVHPGPGVIGNCKPSGLDEADGKGGEARGVSYVDGVYIDSRTDMSNARSTWPECFYLVVTGRKEPKAGWNFRGRCEIYYQGTTPNKNDYRVWYVYPNWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPX0</accession>
    <name>A0A1C1CPX0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06903</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPX0"/>
    <dbReference type="STRING" id="86049.A0A1C1CPX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06903"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05455"/>
    <dbReference type="eggNOG" id="ENOG502SA90">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="29"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="558" mass="59845" checksum="C9C21F4047C004A3" modified="2016-11-02" version="1">MSLCPNGAPPMFLPWTNVTVTTNQKAITRGIQVSMGSPPQIVSLRPSTTDDVLYVVNREQCSPQYNDSCIGLYGGVFDYSKSKTFLQVAEGQWNGTLESNPNQLSFVHFNDLLTFGNASIYGYPAVYDEPGYGGQGVIPLGSGSDFLRIGVETNSTPSTVYGLWPGSRSIDHPVDGSLVIGGYDTTRINGTLTTFDSQEQCEMCVVITALSYSDENGTTNLFSNSSESLPVNLNPSQRVLYVPQGVWENFKTATGGYYNASYLSYASTAVPTGHVTVTLQNGYKTVIPAEELFYYPRGYNDDGEYDVIDNTYQISTIVNTTNDGYVLDWGIPYMTMNYIIADYKRSQFQMAPAIRTNFDNIGGGYALKASCDPTTEATPAPTVSATAGPASTTAAVSSHHSSSNVGPIVGGVVGGVLGLILIVGGLALLFYRSRRRKNSAAGGEHGQPMMTQPMANSGMPHNGGSQADRYSHWTAMSPTEAPTELGGGEKMNGAHASVNQWLSSQASDTQTVVSSTSPNPNVGATLGYNMGSPQTTHQQQMGSMDRPFEMPAQPYDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ18</accession>
    <name>A0A1C1CQ18_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ18"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ18"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07820"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05415"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="85" mass="8993" checksum="8982EB1C092DDC99" modified="2016-11-02" version="1">MVQNGLEAFAAAGMAPGRGFTFVDVDKVVDVAGRFAVDESLHGRAMMIVPEPGGVIDVKDDEEGLWGGVVFKGTQERMRASGLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ62</accession>
    <name>A0A1C1CQ62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">nimA</name>
        <name evidence="19" type="ORF">CLCR_06703</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ62"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ62"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06703"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05385"/>
    <dbReference type="eggNOG" id="KOG0591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000697">
        <property type="entry name" value="G2-specific protein kinase nimA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000151">
        <property type="entry name" value="G2-specific protein kinase nimA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="11"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="397"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="532"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="542"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCT50628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="763" mass="85304" checksum="6D0160D988B2A284" modified="2016-11-02" version="1">MALEPADNDKYEVKEIIGRGAFGIIRKVHRKQDGHVRRAHAVHMVSTDWRQVLCRKEINYLKMSQKERDQLHAEFSILSSLNHPNIVGYFHREHLKQTQELYLYMEYCGGGDLGTVIKDLKRKKEFAKEEFVWRIFSQIVTALYRCHYGVDPPEAGSDFSRQVLPPSTKGKMILHRDLKPENIFLGADQSVKLGDFGLSKMIQSHDFASTYVGTPFYMSPEICAGEKYTLYSDIWSLGCIMYELCTKEPPFNANTHLQLVQRIRKGDFPPIPDIYSKDLANVIAHCLKTNQRQRPDTSSLLTVPYIWLARRQQEMVALGQGLKTREEVAEHKIRQAEERLSALEADRAVLKHEIDSQLRREWELKARLEIDRQVQVELERLRKKFDKEVEERAAQVLARQNPSNDGPVPREIRNPPGPVYGRENLNPSSSFNTAGEEDFPSTTDITDLSDLSIQSPITSSKPPAKKTKTPFARSKTTFDSPVDVQMSEPSPMSISSLALSPRRNATAQATANTTVTAAGAKNIFAEAARQKARWEPRLAYSSDEENIDPADDSDDDEFPDLHSPTRPKAKVADTDPFKNPSPLRNRPVVTRQNTTATMQKLITKPTLFPSTNTAAQVRAGIASGKIANAIKGIPRNATDGDLKATAIKATSPNRRLSKIPSRNDLREHAIAEEGSTSPLRRAATIGGGLRSKLAGSNDPAGGLGVAGRTRVELHQARAGGLPAKARVAEKDLPPVPIWDPEICGDEMPSPFLKKDVKQIRLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQE7</accession>
    <name>A0A1C1CQE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5'-3' DNA helicase ZGRF1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQE7"/>
    <dbReference type="STRING" id="86049.A0A1C1CQE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06710"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05276"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052800">
        <property type="entry name" value="DNA_Repair_Helicase_ZGRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535:SF1">
        <property type="entry name" value="PROTEIN ZGRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535">
        <property type="entry name" value="ZINC FINGER GRF-TYPE CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' DNA helicase ZGRF1-like N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="769" mass="84815" checksum="652A9A482416D910" modified="2016-11-02" version="1">MAALTPGSQSTAPVHEFRCLYTRDLHKKSKKWHDGSVRFHTFNRRVMAYDDSGTFIDDVHYRQEEEFAEGVEIRLDRGVLVEVGERLGQTQTDLAPILDRQRAEKAQSPRRQPLSRANRLQATASSQRPKSLSEVLGPSQGRLGRARILYQSPYEQRYTSARREQPEPSPKRQRLSSDKEDRFDGGHPSIRPARPGLPQPKQPSKPIPHPSRPKEPPIEFEEVLDLSADDEPKRHPPMRVRLTAKSKKTDKEAPEKPTLTSGFSCPRSTSLVRPVGFAEQAGKDKGSGKKPKHSSNSNKPSTRTHPITSRSSSTKTARLLLGRPKPRQKLTCVLPFSSGPSIGEPVARPPLPSPCRKTVSTSLSPTAKALPLDTDGQTVADEPILTIESPSCRSSIREPQSSPHHGISSPLFMPEDNVDPTSPPPSQVFTQEEFPFSNIERSETFDDLGNVGISLRSIHARGPQSSPQNGAETEGGDGPAEQTGSDTRLEPEPQDGAESPSAAKAEDHVQSQSLQNPEEAEIGQDVDETGSRSRSEIVDTVECGEQEKAAEPEPETRSAPKKLVIEERQTEAGKGVGNHEQVETRRIPQLCINNVPQPFTSRAGDRLVVQNQPSPSSGHAAGFQGRSFRRVLSENDALDEEDRTPVPRPDVSNPRHPLGLLENLTTRRSSVKSRSPSKVQRCASDTLACDTAEQYVSRPPAEGSKGPTGPWTVEEAFLLFDWWPAELEKPGYWIDTTVEPVSRALREPHSNWGGITTARQFLRDDVHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQQ1</accession>
    <name>A0A1C1CQQ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQQ1"/>
    <dbReference type="STRING" id="86049.A0A1C1CQQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07275"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05220"/>
    <dbReference type="eggNOG" id="KOG2362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="136"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="327" mass="36545" checksum="9C300B7919E71FF0" modified="2016-11-02" version="1">MSTLTVQRLFIYPVKSLPPVQVSSVELTNEGLRFDRSFVLVNPPKDDSRRAKFLTIKKLYKLALFKPTIDDSWTKLTIHHTRATPSSSVTVPLTPSPLSLLTNKTFEVSIFGTTAIGIDLGEEAAAFFSKHLDQDVRLLSIGGTGRREIPGAAYIPSQRSALSLALQEGLQPQRIRFADAAPLLITSTASEEDARSRLPPAHQDEDVIIRFRPNIHIDVKTQLPPYDEDNWSSLLVRSHSDEAQEVTIKCIFRTVRCLSLNVDPDTGEMIQRERQLYGLLASDRRVNDKFPRTTDKPVFGQYAFAGPSGAILRTGDAVYVTERIQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRN1</accession>
    <name>A0A1C1CRN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase domain-containing protein 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FAHD2A</name>
        <name evidence="4" type="ORF">CLCR_08782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRN1"/>
    <dbReference type="STRING" id="86049.A0A1C1CRN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08782"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06914"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="71"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="282" mass="31032" checksum="5C80D4B6C46D6092" modified="2016-11-02" version="1">MAVTFERLVRFRAPDGQIYYGEAGSEWQSDLKGREVQTFSGSDPFEHGFKLSDKKAVVSEVLSPLERVPIVLGIGLNYRKHAEEAGFPIPTFPVVFTKYADTLAGPFEDIPINPEAHELDYEGELSVVVGKDIKNLSEKDDPLDYVLGFTVGNDVSSRYWQVAPRSGGQHGPAKSFDKFAPIGPVIASLKAVGNPETLKLRTWVNGEIRQDGRTDDLIFGISAILRHISRGTTIRKGTGIMTGTPSGVAAFMKPAPWLRDGDIVEIEIERIGKIANKMVFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRR0</accession>
    <name>A0A1C1CRR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_08772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRR0"/>
    <dbReference type="STRING" id="86049.A0A1C1CRR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08772"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06915"/>
    <dbReference type="OrthoDB" id="153074at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05367">
        <property type="entry name" value="SPR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="275" mass="30210" checksum="B0C5E13471C9F37F" modified="2016-11-02" version="1">MATAWFGPSPDWIWKHRTEHPSAKTILLTGATGGIGLAVARRLLSSGDEHLLILTGRNVDVLRQFEREHPDRVRAVQCDMADLGQVAGLVQHCEVHGSLDALILNHGTLGNCLRVAQMAGNKGEEWERVFKVNVTSCVVMISEALPWLRQAKGRIIFTSSGAAQNAYPSWGAYGASKAAINHLTMTLKNEEPDVTTVAIRPGVVDTAMQKDIRESFLSNMDEKDQQKFRSAKEDGKLLPPEKPGNIIAELAVSAEKELSGSFLSWDDPKLKDYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRU1</accession>
    <name>A0A1C1CRU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP synthase regulation protein NCA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08302</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRU1"/>
    <dbReference type="STRING" id="86049.A0A1C1CRU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08302"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06872"/>
    <dbReference type="eggNOG" id="ENOG502QTT6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="569" mass="64251" checksum="ABA55089EF9A52D4" modified="2016-11-02" version="1">MSFIDEVDAALDKFQLREAEERVSTAAATSSEDPRTSQLKAVVRALSTTSSSRPLIRRTRLRSLLGQLAKRDGEHVSAETASPAIANLEWVAAGKATAQVYGLILSSLLDRTIPLSESIWYWDDLLSSYANIVLYTIQTSPLRFWQQAKEVYADARHKFRQGQVLQTSARDATRTVTDSWREFYALVQNSVQERSLAQAQTKILSPFSIARVEVRRNLDHIRHLRKSNAATIGRLVRECLVFGGPPEDRKRGALVQLLEPEDDDWQTTIARTAYLLDISTRATHEDEEEYTSIDPQTASSTEVAGLLLKVLDQRLPKQEQEANKLSSRYGKPSRLIRYWIPGVVLVLSGSTLLRIFVNRRAEILQWFRELGQTTIDFWTNWVVEPVKKLIGTIRHDEQSEIAIQSRDSLRADRDSLERMVVDFAVQHPEDGKNFTEAQVAEIRAKVKEGDLTPVLKAYEREMQSPIKNAIMGDLIRTLLIQVQKTKVDVEVAIGGIDSILKSQELLFGFVGIAPGVLITYALFQWFASTFGGRRGLRQGQRKGEAVRLIRFGNLPKIHAPLLTVVEQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSN5</accession>
    <name>A0A1C1CSN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08922"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06567"/>
    <dbReference type="eggNOG" id="ENOG502RY6P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3596006at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="279" mass="31750" checksum="B2057A5076AF50C9" modified="2016-11-02" version="1">MAPVIWGLDLRDMKWSMFGSQWMWKNKDYHLRRTKFVIYQLAMICMVASESIGTAALSDYVKQQSTIERLHSSASVHNDDFVGIASYNIFCGIVVATIFGAGFFFDLFFPERYEPKNIRWAWRLSAVFVTLCTIADALAFTVIVATGKAWISANSRDAEQIALEHINPPRVYRHNHRAIAATVFLWIGMVATVASCIILWMYYAHLDAYGPKSLSARMRDEVDKTTLVNERAQSGMRTHEQMREQTVYNTTTGKRQVTLAKQSRCDSLELTPSLSPDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT62</accession>
    <name>A0A1C1CT62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT62"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09359"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="80" mass="9318" checksum="D8813400DCEC3499" modified="2016-11-02" version="1">MERHFRHEQGCQRLVRADDLCKTDGDSTRAPALQADWLTGRRRARDDKETDTRNRADLDAHPLYQERSGTQRTHDQLTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTS2</accession>
    <name>A0A1C1CTS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_09133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09133"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="161" mass="17643" checksum="0AEF915C40E8465D" modified="2016-11-02" version="1">MGDLVWCDKMFRRQMPLEVVNTSVTVSAQMTGKSVLAVTPPMSLPVGPVGEVLRRTTGIARPTMPTVRREHVSGEGALCTVHAGAARARELNCLWCLELDVELNRALELDIKSRSNCGKMEGNRRSEEKLYTLYQVNAAKALCLSVRMLLNALGVPDFAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTT4</accession>
    <name>A0A1C1CTT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09330"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06231"/>
    <dbReference type="OrthoDB" id="10392261at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="99" mass="10196" checksum="0FF701632CCF57EF" modified="2016-11-02" version="1">MQTPATVDSKACAASTLVGSPLADEERDRMTASSGARVCHQGDNVTANTDMSAAETGVVVKAMTDQKAGVVHSATMDDEDMDAASVAGSFSLQDDYIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTU8</accession>
    <name>A0A1C1CTU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09082"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06201"/>
    <dbReference type="eggNOG" id="ENOG502S5UU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5363135at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="72"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="178" mass="19299" checksum="2E0A80A166AE84EC" modified="2016-11-02" version="1">MSADTSDLTKVDSAIAGVDSTAAKDGAKETKRRTTSSAPGVMNINDLANTPKEKEGTTIAVAPDTQKTGWKLNTSPSTIEDASILKKPLTTPPVKKIDLHFPLGLEVTARNLKGVTIKDALDAIHKQFKKKADDEMEEPYLKGFEWDPEESWTRLKVHTQKEGLPAGGKKSKKKGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUQ1</accession>
    <name>A0A1C1CUQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08740"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05929"/>
    <dbReference type="eggNOG" id="ENOG502SD3B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4159136at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF5">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="335" mass="36340" checksum="BBC225A6C33E4F9D" modified="2016-11-02" version="1">MASTTQSWAAATQSWASWLLDSYASSVSPLATDTSFHHHEDSHSVSESSYHESHSSVSSISLSSAYGPYVKSGRGGAGNFTWETDLQLAPRSSSPVDLEANIPQRQTSLAERRKAAARLEHINTQETMRLRQSSTQYRGLGRGGAGNYASTDMLPIQRSVTLPATLISPSTPKPPSPKHQNLHPSVHPGRGGAGNYAAAAELSGRAETGKEQEERHAAEQRREQIVEEVDGLIQPPPGAWLGGRRKSESMYDQNTEGRDDKQAISPAYQAIEQGDRPASLTTGPLASSEIDASTRHLSAKSQTDANQRDPCRYLTDPEVSRQTFDNAGNMEMSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVB8</accession>
    <name>A0A1C1CVB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein, Mpv17/PMP22 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_10792</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVB8"/>
    <dbReference type="STRING" id="86049.A0A1C1CVB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10792"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03829"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT52430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="202" mass="22204" checksum="33085AA474E5398D" modified="2016-11-02" version="1">MPKPSKPPPSSLKGPSSKLLRVTLEGAVMSAVSNSLAQGFNAYREGGSAIDPLAFIHFVILAIITTPPNYKWQLWLEETFPSNPKREGPAPTGKKEDDARVEDDKAALSITNTAAKFLLDQTLGAGFNTLWFIVMINLLRGKSFEHIATIVQNDFFPMLMAGYKFWPMVTLVNLVVVPFDQRMLVGGLAGLAWGMYVSLTQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVJ2</accession>
    <name>A0A1C1CVJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative phosphoketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_09589</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVJ2"/>
    <dbReference type="STRING" id="86049.A0A1C1CVJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09589"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03885"/>
    <dbReference type="eggNOG" id="ENOG502QUUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2532903at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003619">
        <property type="entry name" value="PRK05261.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF1">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="41"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="599"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT52488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="815" mass="90408" checksum="6FC33238DC3FFD30" modified="2016-11-02" version="1">MPGEVIDSPNPQPQPSNVPDYVSDLLVKLEKRPLPDNTNDVVAKFRRAANYIAAAMIFLQDNVYLERDLTHEDIKPRLLGHWGTCPGLTLLYSHLNLLITKLDLDMLYVVGPGHGAPAILAALWLEGSLAKFYPRYSQNAEGLHNLISGFSTTGGFPSHISAETPGSIHEGGELGYALSVSFGAVMDNPDLVVCCVVGDGESETGPTATAWHSYKYIDPAESGAVLPIVHVNGFKISERTIYGCMDNKELAALFTGYGYQPRVVDDLNDIDADLSKSMEWALGEIKRIQKAAREGKPITKPRWPVLILRTPKGWSGPKKVHGTIVEGSYKAHQVPLPHAKSDAEELKQLQEWLESYKPKELFKENGDVIDEIKSIIPTNPDRRLGQKKEVSGAYRGLEPIDWRKFTVEKGSSESSMKAVGRLLEQIVKDNPKTFRIFSPDEFESNKLDAVLSSTNRNFQWDQFSRAQGGRLIEVLSEHQCQGWMQGYTLTGRTALFPSYEAFLGIIDTMMIQYAKFGKMSRESGWRSDISSINYLETSTWTRQEHNGYSHQNPGFIGAVLNLKPNAARVYLPPDANTFLSTMAHCLQSKNYVNLMVGSKQPSAVFLSADEAENHCRAGASVWKFASTDDGLNPDIVLVGIGAELTFEVIAAADILRSELPDLRVRVVNVTDLMILGASSSHPHALTDDAFDALFTEDVPIHVNYHGYATELKGLLFGRPNMHRVTIASYNEEGSTTTPFNMMLVNGTSRYHVAMQAIKGAAKRNEKVRLRLHELTSELTGRISEVTKFILKEKTDPEFLNEVKNFKIDTASMSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVP6</accession>
    <name>A0A1C1CVP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVP6"/>
    <dbReference type="STRING" id="86049.A0A1C1CVP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10631"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03942"/>
    <dbReference type="eggNOG" id="ENOG502SINW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5587021at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651083" evidence="2">
        <location>
            <begin position="25"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="291" mass="29425" checksum="B384969D873FFC8F" modified="2016-11-02" version="1">MSSSICGLVLTIFSLLLLVPHISAQTSSATTPSSGSNGSTTPSTNSPTLTPTAASSTAPDVYLNVPTLSVGRIELDVDDLRADINLNAQVANLVTLNAGVAVSIQEVNLTISDVDANLELIVRLGHLVDIVNRVFESLDLNPLLISTINNVTSLLEPIVGAIDGLLGSITQGGTTLSFLIDNLGNIVQEVGGVSSIVGNYVSNMTDTGVSKTLSGGLVQKTFSYAPLNALVDIVFNTAGQVVQASVQKQNGGGGGGGSGGSTSTTSVASTTGSSTPASSSTAARVVNPTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVT0</accession>
    <name>A0A1C1CVT0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVT0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10243"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04020"/>
    <dbReference type="OrthoDB" id="2951834at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="445" mass="50017" checksum="09E2833952CDFDBE" modified="2016-11-02" version="1">MSTPVVPRRPRGRPRKDTRPALPGLVTYELNTLADPCMTLRYNPSKKCLCAHQSTIEIGDPICPYHGCYDDKSKTFSRKDTASTPVPRKRKRDDDQEGEEQDHGPQLSPLLTMTDKRQATGRIGPENIAEERVNVGPCLLKEQAQQLLDDGSPFDQHPDASPNSEIGPLVEIDFLKAPLEARKLIYRYLLVPSSRSITFPSQLASNTFSELNPELQTKILFTHPVVYNECRPILYGGNTFVAWSATDFFLPTGIQGLRPATARRIKHISIVRKGTANQCDITSHALASSLHRMVLQSPAFLGLRTITFRFEVGRPVHMNLFTLQMYLSSHNVTADVRAMYKKAKVVKDAAAKVAFKALQKGSPFQGLCLVEESEHTIWVPGRGRGSHTVNVNEVCLFRTPEAGDTYEEEKQMLRTAILDVLRDEKVNDVPGADRRYAWFYRKCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVY9</accession>
    <name>A0A1C1CVY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related protein RABB1b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RABB1B</name>
        <name evidence="3" type="ORF">CLCR_10668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVY9"/>
    <dbReference type="STRING" id="86049.A0A1C1CVY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10668"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03975"/>
    <dbReference type="eggNOG" id="KOG0098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001537">
        <property type="entry name" value="Secretion related GTPase SrgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="262" mass="28521" checksum="84FC5D65A72BDE9F" modified="2016-11-02" version="1">MPNITPAPTLPWNYIAKLVCIGDSGTGKSSLTIRLCEGRFSASHDVTIGVEFGSRIVPVGPPANASLDLGTPNGRESHGGKQEQKKMKLSLWDTAGQETYKSITRSYFRGASGALLVFDITRRSSFESVTQWLNDLRQIAEEGIVVILVGNKLDLAEQTTDVQGGTKRAVSREEAEDWCRRENIVKYVETSAKSGEGVEKAFLEVAERIYQNIEAGKYDLNDRRSGVKGYGMGGGRDEAKAPKTVNLTVNDTIRSGQGRGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWE6</accession>
    <name>A0A1C1CWE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWE6"/>
    <dbReference type="STRING" id="86049.A0A1C1CWE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10023"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04125"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="491" mass="55247" checksum="A2FA4D698F15D8E8" modified="2016-11-02" version="1">MFVLAYPGIILALGLAYLAIDTIYSWYRLRHVPGPFSAGFSKWWLFKHTWNGTLYLESAEQCFKHGSLVRIGPNDLITNDPDILKRMGAPRSPYRRSDWYNALRVDRENILSERDEERHAMLRNKMAAGYAGKENPTLEQGIDDCIAKLVDLIERKYISTAEEFKPLDFARKAQYLTLDIIAAVAFGGAFGFLEKDEDVFKYIQTTESTIPAMILCAAFPWLSTLFQSPLMKFLMPKDTDVYGLGRIMGAAREVVQERFQPDAKPRMDMLGSFLRHNLSREDAETEVMVQILAGSDTTAGSIRATMLHLLTNPPVLAKLLAEIQSADISDPIQDSEARKLPYLQAVIKEGLRIHPPVTGLQSKVVPPGGDTLNGYYVPAGTRIGSSAWGVFLDPGLWGPDARVFRPERFLEGTPDEIKRKEIDIEGIFGYGRSSCLGKSVAAIELNKVFVQLLRKFEFTIVNPQQPWKSFSAGVFIVSDMWLRVTKREQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWZ8</accession>
    <name>A0A1C1CWZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Very long-chain acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SLC27A2</name>
        <name evidence="4" type="ORF">CLCR_09813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWZ8"/>
    <dbReference type="STRING" id="86049.A0A1C1CWZ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09813"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00070"/>
    <dbReference type="eggNOG" id="KOG1179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF20">
        <property type="entry name" value="FATTY ACID TRANSPORTER_ACYL-COA SYNTHETASE (FAT1), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G11360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="64"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="652" mass="72092" checksum="F96B3E23215838D5" modified="2016-11-02" version="1">MATIAASTAAAAGLLYYADQRVLGISRDLKYYRSEQDFAKRMPGFINKVGPQSPHLYRMLELADPNADALYFEGRSWNYRAFKAKVDEIALGLHESLGVKDGDIVAVFMTNSPEMAFTVLALTRLGAAPALINNALRDDTLLHCVRLPNSNLILCTPDLAPHAASAAKSLGGSIKTVSLNVGTYRPAPVSDGSNNIIDFPFPEPTTSAILPPTPPKSVGSVAALIYTSGTTGKPKACSVKNGLILGVSCTSSPDAANPKKYLQGLRIYSCMPLFHGTTFFAGFCYSISQSGCFCLGRKFSARNYWKEVHESRATRILYVGELCRFLLATPPSPYDRKHHVIVAAGNGLQKDVWVDFQKRFAVPEVREFYRSTEGLVKFDNIHRAGAPGAGKVGYLGVLRKHVLDKDQHIIRFDYDTEQPVRDPKTGFCQVASKGEPGEAIARIHNMATYTDYHNNKAATEQKLLRDVFEKGDLWQRSGDLLVQEHDNWVKFVDRIGDTYRWMGENVAAGEVRGFISELPGVMDAVVVGKRLGKYDGQVGTALIVLESNGSDEKEKPGSDRGEKAFMARLFRDLRAKGVPRYAVPRLVLVRNELVDVGDTFKHAKVVVKNIDWGAEDPSGRTRKYYLDMEKEPVFRQLDANSWKRIEEGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXJ8</accession>
    <name>A0A1C1CXJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11026"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="118" mass="12836" checksum="E6313E1FF7BCA5BE" modified="2016-11-02" version="1">MSCVSPYNKDASFAMPHAARNAVRASNYKHTQRDNARYCSTSRRSQRNKGYGAVGAPPSFVPILERSAAYRAGTRGDPRATVTIWPRGSPICSIAWFEVSRRRVHLEGVAPAVVASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY01</accession>
    <name>A0A1C1CY01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Epoxide hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY01"/>
    <dbReference type="STRING" id="86049.A0A1C1CY01"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10608"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00345"/>
    <dbReference type="eggNOG" id="KOG3085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1694274at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28919" checksum="74B33B74CFDF3FF0" modified="2016-11-02" version="1">MASVQSRPKVLLFDIGGVCVVSPFQAILDYEIQHGIPPGYINYSIRALTPNGAWHKLERGEIPNDATYFRLFKADLERADLWARFHAEKLNVSDPPPVPAIDAETLYWNMMAHSRKPDPWMYPALLKLKAHGWRLAALSNTTVFPDGHPFNEPGPEDVKGVFELFVSSAHVGMRKPNRDIYEYTLKLIRERWGQDIRAEDVVFFDDIGENLKTAKSLGIRTVRVVLGKTKDAVRELERLTGLELVGEPWVSKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY88</accession>
    <name>A0A1C1CY88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 13">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">hog1</name>
        <name evidence="15" type="ORF">CLCR_10202</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 13"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY88"/>
    <dbReference type="STRING" id="86049.A0A1C1CY88"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10202"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00367"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT53398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="369" mass="42044" checksum="59E7B702CE99CCF8" modified="2016-11-02" version="1">MAEFVRAQIFGTTFEITSRYTDLQPVGMGAFGLVCSAKDQLTGQSVAVKKIMKPFSTPVLAKRTYRELKLLKHLRHENVISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPQDVIETICSENTLRFVQSLPKRERQPLSSKFKNADPAAVDLLEKMLVFDPKKRASAAGALEHEYLSPYHDPTDEPVADEKFDWSFNDADLPVDTWKIMMYSEILDYHNIDNGETELGGKPLTVEQAQAVNQQVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYC7</accession>
    <name>A0A1C1CYC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 26S proteasome regulatory subunit rpn7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpn7</name>
        <name evidence="4" type="ORF">CLCR_10114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYC7"/>
    <dbReference type="STRING" id="86049.A0A1C1CYC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10114"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00504"/>
    <dbReference type="eggNOG" id="KOG0687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000013">
        <property type="entry name" value="Proteasome regulatory particle subunit (RpnG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000021">
        <property type="entry name" value="Putative proteasome regulatory particle subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="232"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="109"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="482" mass="53285" checksum="746453EDF671B094" modified="2016-11-02" version="1">MGSDPQFAKYPDLTLAQHIFTLANAPQTNQPTSLTYLQNAIKDHKMAPLYRHLAHPTEGVLNAVGESTAQPPQPPSKPLARRASLVSSNLLPPKKPVPSGILPWDESLYEELKAANEKELEQFQKEEEEAEKEAGETEIQAARSKRAEFWARVGDKDKAIAAYEKVFDKTGPLGTKIDIVLAIIRIGIFFNDKAFAKKQIERASILVESGGDWDRRNRLKAYKGLHLLTVRSYNLAAPLLLDSLSTFTSYELCSYSSLVVYAVLAGSLSLKRVDFKAKVVDAPEIKAILGDTEDKAEGGDEEMKDVSASTAERASGLVNVNALGTGGAVESQTEAPVDVSSLGQLVNSLYTGNYRKFFLALAAVEENFLTQDRYLYEHRAWFVREMRLRGYQQLLQSYRVVGLATMAQAFGVSVDFLDRDLAKFIAGGRVSCTIDRVQGTIETTRPDDKNKQYADVVKQGDALITKLQKYGQAVRLRGSERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYN2</accession>
    <name>A0A1C1CYN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar isomerase, KpsF/GutQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYN2"/>
    <dbReference type="STRING" id="86049.A0A1C1CYN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10306"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00523"/>
    <dbReference type="eggNOG" id="ENOG502RDRP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1872003at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF/GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418:SF2">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF_GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="87"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="414" mass="44622" checksum="8B83D965CF23C3C4" modified="2016-11-02" version="1">MAYTHQTYLPTPLTPSMPLCGPLADQLEPLPITPPDIPAAFDERTFSPDSRTIKKALHVLATERQALSHLEELYSTSAEAQESLLRAVSQIINSEARHGKTIFTGVGKSGHIAKKLVATFVSLGIHAIFLHPIEALHGDLGVVRPTDTVIMITFSGRTPELLSLIPHIQHCIPLILMTAHLSPFTCPLLSHTARQGATNILLPTTIHETETSSFGVSAPTTSTTITLALGDSLALAVADELHCSTGVETPAVFASNHPGGAIGAAFKSTTQSVPRMADLATTVSQVPIALPQADQPLLCFNVLLAAVKSPRGFVRTSNNHIIGPRRIQGIQDPTVPISAVEDEFGRVVVERTDWISVLNSTTVEECRRWIHQMRNEGAGRGRDFLKRGTLLGIVEHNEVTGVVEIEDVMGEDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYY4</accession>
    <name>A0A1C1CYY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Glutaminase</fullName>
                <ecNumber evidence="12">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="17" type="primary">hisHF</name>
        <name evidence="17" type="ORF">CLCR_09766</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="12"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYY4"/>
    <dbReference type="STRING" id="86049.A0A1C1CYY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09766"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00607"/>
    <dbReference type="eggNOG" id="KOG0623">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254903at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000094">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000039">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014640">
        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="16">
        <location>
            <begin position="6"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="382"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="420"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="492"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="518"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="541"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT53661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="575" mass="61877" checksum="9521EFBB9C267C12" modified="2016-11-02" version="1">MPTVHLLDYVAGNIRSLVNAIEKCGWEVEWIRSPEDVEKAEKIILPGVGHFGHCLNSLSSAGYLPAIQKHITAGKPFFGICVGLQALFSGSAEAPTVPGLSLIPASLNRFSGSNEDGSRKSVPCIGWNDAFTLHHDRDQDHQGEGRSFYGLNPGSKYYYVHSYFAPYVAGELEEQGWTVATATYGDESYVGAIGKGNIFATQFHPEKSGAAGLRVIKAFLEGNMWSDPVRASIPGTATPSNGTATKDGGTNGLTRRIIACLDVRTNDQGDLVVTKGDQYDVREKTAGSQVRNLGKPVEMAQRYYNQGADEVTFLNITSFRDCPITDLPMLEILRRTSETVFVPLTIGGGIRDMVDPATGKTISALDVAKLYFASGADKVSIGSDAVLAAEEYYSAGGKLSGKTSIETISAAYGAQAVVVSVDPKRVFVSSGSETAHHTIKTTEPDAQGREHVWYACTIRGGRETRDLDVVQLVKAVEAMGAGEILLNAIDRDGSNRGYDLELIDMVKSAVTIPVIASSGAGNPAHFDEVFRKTKVDAALGAGMFHRGEYTVMQVKEYLGRAGLLVRPFEEFDNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ79</accession>
    <name>A0A1C1CZ79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ79"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10874"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00773"/>
    <dbReference type="eggNOG" id="ENOG502S3HU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2937326at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF1">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="3">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="188" mass="20985" checksum="88D3C6FFD68F93B9" modified="2016-11-02" version="1">MANIPLAYKIFFLWIEPVATLAGAYYAWFKPSTYLEDTHLPSAPGILGLPTSTHVVLRQLGNLYLAFALNEAFVLRATNDLKVWRSLLLGLLIADFGHLYSCYPLGVKTYYDLVNWNAMAYGNYLFVYCGAATRICFLLSVGMGGPKRAKSKVKKSVRLALEEAPPVTPQQMNKSPAQSTRRKKNRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZL3</accession>
    <name>A0A1C1CZL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent Zn protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZL3"/>
    <dbReference type="STRING" id="86049.A0A1C1CZL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10117"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00863"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2115716at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF132">
        <property type="entry name" value="ATP-DEPENDENT ZN PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="3">
        <location>
            <begin position="251"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="497" mass="56412" checksum="728E8B23B25946A8" modified="2016-11-02" version="1">MDTEAFTRAEAGSGDGGVAATYFRHATAPRVDTDAVIYDSIATAHPGVPITTVPDWSCNLRAYAAAGHGVLETVEAPSPSSSSASSSTPSAADPKPDAKHIWPSTLRWTVYLPPTRRLDGGEGVVADEVFFETCTYTWEGFTFLVYFSEGRDGLLSYPQVRNQYILGDPAGARALVASAGRWESVLHDEIWVFNQGYWQKDPFLYRSILKSRWEDVILDDDLKTDLVDTVERFFDTRDVYDRLRVPWKRGVIFYGPPGNGKTISIKATMHTLYKRDPPVPTLYVKSLVGFVPAEYSIESIFRKARQEAPCYLVFEDLDSLVTDQVRSFFLNAVDGLSENEGIFMVGSTNHLERLDPGIAKRPSRFDRKYLFPDPDFHQRVKYCHFWQRKLSDNKDIEFPDEICGAAAKITDGFSFAYIQEAFVSALLEIAREKDTARQNVRREMEDVQEKWELLELEGSAETTAKDKDLEDYILWRKLKHQIEMLRKELSKEKRGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZS7</accession>
    <name>A0A1C1CZS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10125"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00885"/>
    <dbReference type="eggNOG" id="ENOG502T7YQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4137691at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="493" mass="54892" checksum="78D058AAF7822BD4" modified="2016-11-02" version="1">MYATPGRPVTNRAKVICPSCATRVQVVWRALSSSPALSAKRNRIPNHVKQANVKGQGSLGGIPAPKSTGLRQRENPVFIAPELVTGLQKLGFSSIPAVVDVLRQLNQEATKLSPTNVVQALTTQQHFTRIAEQELGTVEAALVRDPKVLRQAFHLLGRNYFHQQNRQGQQGLAALRIAFFAGEVDAGIDAATAEVMVNISRVELGATSTTGTLLSARLFEFIKQRAQARADWRAMTLYLKEMSRAPGTEASARDNYNLARELFDMLEPSKELVLENTQLLRGVEPPWKILYEAAVAYLAYIPKGSPEHDKVQADVETALRDGIQKYSDPRAVAPALRQQRVIPWHSPEWVDLATQAAAAGVQDAAFDLAMYYLRLGGWRPRQAGKKPTDWTGIEWLAVSAALAAPDIRAMVQSRYLGLAHLLREHGYLAEGYAWMEYAKENAAEAGLDPDKEWEHFIHDFELAWAKAEKDDEMQKYIQHSDKFFAPYLDGRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D042</accession>
    <name>A0A1C1D042_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RDL2</name>
        <name evidence="4" type="ORF">CLCR_00340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D042"/>
    <dbReference type="STRING" id="86049.A0A1C1D042"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00340"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09407"/>
    <dbReference type="eggNOG" id="KOG1530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01519">
        <property type="entry name" value="RHOD_HSP67B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="46"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT54164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="151" mass="16639" checksum="90D6B64EC1787BE1" modified="2016-11-02" version="1">MPLRQPKRHFTTSWSAQKDESSSFSSSAQQSRLYTFDDVQSLSSAPSPNRILIDVREPSELQATGKIPNSKNLPITSAADGFFLPADEFEERFGFEKPGKEDEVIFYCKAGVRSRAAARLASQAGFGGTVGEFPGSWVEWSDKGGEVERVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0T7</accession>
    <name>A0A1C1D0T7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial peroxiredoxin PRX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PRX1</name>
        <name evidence="9" type="ORF">CLCR_00936</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0T7"/>
    <dbReference type="STRING" id="86049.A0A1C1D0T7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00936"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01590"/>
    <dbReference type="eggNOG" id="KOG0854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="10"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="229" mass="25397" checksum="F0F16F9691462A6C" modified="2016-11-02" version="1">MGSTGRPEPLRLGSVAPNFQAETTKGPIDFHEFIGNNWVVLFSHPEDFTPVCTTELGAFAKLEPEFTRRGVKLIGLSANTIDSHGQWIQDINEISGSNLQFPIIGDKQRQVALLYDMLDQQDATNVDEKGIAFTIRSVFVIDPKKTIRTILSYPASTGRNTAEVLRIVDSLQTGDKHKVTTPINWVPGDDVIVHPSVKTEQAKEIFPDMKIIKPYLRTTPLPKDKTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0X1</accession>
    <name>A0A1C1D0X1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Bifunctional purine biosynthesis protein ADE17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADE17</name>
        <name evidence="11" type="ORF">CLCR_00821</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0X1"/>
    <dbReference type="STRING" id="86049.A0A1C1D0X1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00821"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01673"/>
    <dbReference type="eggNOG" id="KOG2555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT54407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="546" mass="59634" checksum="B59364514804FAAE" modified="2016-11-02" version="1">MLSGRVKTLHPAVHAGILARDLASDEKDLADQNINKVDYVVCNLYPFKDTVAKINVTIPEAVEEIDIGGVTLIRAAAKNHSRVTILSDPADYHHFLEELERGEIPGESRQRYALKAFEHTADYDAAISDFFRKQYAGNGVQQLSLRYGANPHQKPASAFVRQGTLPFTVLGGSPGYINLLDCLNAWPLVKELKQALGLPAAASFKHVSPAGAAIAVPLSERERQVYMVDDIEGIESSGLAQAYARARGADRMSSFGDMIALSDKVDVLTAKIISREVSDGVIAPGYEPEALALLKKKKGGKYLVLQIDESYEPPAQETRTVYGVNLTQGRNDVKISPAETFNSIIRPKDAAASPSSSPLSDSALRDLTVATIAVKYTQSNSVCYALNGQVVGLGAGQQSRIHCTRLAGDKADNWWMRFHERTLGIQWAKGVKRAEKSNAIDMLCSGQIDADLSDFEKADYERNFAEGQVPTPFTHAERREWLAKLSEVAVSSDAFFPFVDNVYRAARSGVKYIAAPTGSQNDGAVFDTAENLGITFIEQSTRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0Z7</accession>
    <name>A0A1C1D0Z7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative U3 small nucleolar RNA-associated protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">utp13</name>
        <name evidence="9" type="ORF">CLCR_00770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0Z7"/>
    <dbReference type="STRING" id="86049.A0A1C1D0Z7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00770"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10131"/>
    <dbReference type="eggNOG" id="KOG0319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001009">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="420"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="536"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="8">
        <location>
            <begin position="781"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="718"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="723"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="992" mass="107078" checksum="FF6ABAD29CF2F4D6" modified="2016-11-02" version="1">MATKVTFKTTFAAAKTIEPIFTGGDISHNADGSLLATCVEEDVLIVDIRSGKVLCRIEGDGEPVTSLCLAPDISHLAIASRSLSLRIYSLTTVEGSTTLVADLARTLKPHTTPVVSSAIDGTGSVLATGGAEGQVKVWDLRGGYVSHTFHGHGGVVSALRFFRSKSTSSASSQKSRKRKSRDGEQMDVDEPSPVQQICLASGGEDGKIRVWNLSTRKAIATLDAHVSVVRSIDFTEDQQLLLTASRDRTIILWDTPTWKQTRVIPALEVVETAGFLVAGKFCYAGGEHGAVRIWDVTTGRELTAKQKPGLENDAIMAIVPVFEDNTVISVHQDQTMRVHDITKLQELQVSESMGRLPVIRTISGNYDEVIDMACVGPERRLLALATNTESVRLVSIAEDSTQEDTNHSSPSSFGNDVALLEGHEDIIICLDVDWSGHWLATGAKDNTARLWRLDPASSSYTCFAVLAGHAESLGAIALPRSPPSDGPALRNPAGHAPAFLLTGSQDKTIKRWDTAKLKYDPSATEPQNSVKALFTRVAHDKDINAIDVSPTSALFASASQDRTIKVWSLEDGSVAGILRGHKRGVWSIRFSPSGTPPIPLPDGGSSGSRGLLVSGSGDRTVKVWSLSTYTCLQTFEGHSNSVLKVIWISPGVLTPRAEESGEDAPRPAQQNESPVIASASSDTLVKLWSPYSAADSDHLLTTLDNHTDRVWALVAPTSYPGRSHPASPKSSKGSSTPTTKQTYPYPLISGAADATLTFWRDTTLATASALSHRATQRIEQDQLLQNHIFTKNYREAITLSLALNHPGRLLRVFQDVVEQNGNEAGDEDGKSITGAREVDAVLASLDRTQLFQMLEHVRDWNTNARTAPVAQRVLHCILKSYPKTTFVETARDKKLVGNAGGGDGAVAGTVTVTGRRGAKARGSAGMQDLLRALEVYTERHFKRMEELIDESYLIEYTLREMDEGIGPAMESSNGQEKGNGVDVDRDADVIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D121</accession>
    <name>A0A1C1D121_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PUP3</name>
        <name evidence="6" type="ORF">CLCR_00930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D121"/>
    <dbReference type="STRING" id="86049.A0A1C1D121"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00930"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01733"/>
    <dbReference type="eggNOG" id="KOG0180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT54472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="195" mass="21337" checksum="3EA2ED6682DF4BEC" modified="2016-11-02" version="1">MSSPFDINGGACVAMVGKDCVAIACDLRLGLQALTVSNNFPKIFNYAPSVFLGLTGLATDVQTVSDTFRYKVNMYRLREERNISPQTLANLVSSSLYERRFGPWFVSPVLAGINHTTGKPFICGFDSIGCIDFAKDFIVAGTASDQLFGTCEGLWEPDLALLNAVDRDALSGWGAHVYIIEKDKVTKRLLKGRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1A5</accession>
    <name>A0A1C1D1A5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_00834</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1A5"/>
    <dbReference type="STRING" id="86049.A0A1C1D1A5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00834"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01770"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="505" mass="56563" checksum="B685AB101170B3EE" modified="2016-11-02" version="1">MDLLSCALLVTSIGITLLFSFLVLNSRQAGLSHIPGPFLARYTDAWALYNAWRGIHFHNKVHVQRGLQARYGDVVRTGPRSVTVFDPAAVPVIYGVRSKLDKGNAYVPFRQAGVTTSLLSIPDEKTHSQYRKLVSNAYSMTSLKGYEPYVDDMVNRFVEVCNQHAFAGKPMNLSLWCQYYCFDVVSKITMGMPLGSMKGEGHDAYGLVQRVRAFGFYSGLVSQMPWLHKILQDNPLMRKTRPSPFMKVVGGTVQARLRTPDPEDQPRPDLLSHFVATHAGYPRLMDEKQVLIMTSGNLIAGGLSPSAAFDELCRYLATHPDSQDKLYGELQQAQCRLPASYDHVKNLPYLEGTIREAYRLHSSTSFNLQRVTGAAGLELPNGVRIPPNTNIGCPAGAINQDVRVYGADADEYNPERWMQRENETIEAYLERRKLMERTDMTFGQGSRACIGKNVAFLEFFKAVATLMAQFKVRQPVPSTPEEVLNFAVQDRLLTHDSNSLNVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1D3</accession>
    <name>A0A1C1D1D3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1D3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00991"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="125" mass="14331" checksum="E7EB7DF2A8538606" modified="2016-11-02" version="1">MPHSARTYCAPPQDPWRGRMALAHTERLQPAIRLETKAKPPSLRLRSRRLDVPASTRSTELNKRRARRSARHFKAIRASANVTIQSPGTKASLTEVVRHWRRVKAKRPQPGANRVRGWELGSQVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1Y6</accession>
    <name>A0A1C1D1Y6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative tpr repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1Y6"/>
    <dbReference type="STRING" id="86049.A0A1C1D1Y6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03079"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04866"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="287" mass="32154" checksum="B9F77D39CA23E510" modified="2016-11-02" version="1">MAPPIAKPPTATSFRGPLQVLAVGLPQCATTSLKDVFENPHLLNIGPTMHMGRCLQLPPNLRFIWEALQERDAQNRRAILYKLFAGCAATADFPGHLFLEDLIEMYPDARIVLNVHKGGGVDGGGGGGGGGAGEEWAASLKAGIAPFMSWQYRVACFWSVPDQWHRLCLMEWQRFAREKFRVDNVWSKDLYDMHNQWVLDVCRRKGKDVLVWDPSMGWAPLCDFLGREKPEVGIPIADAEKEETKSVIQRRLRVGLKLWMRIVVVPIAFSVLGGWAIQRALSLRLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D257</accession>
    <name>A0A1C1D257_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rps1</name>
        <name evidence="6" type="synonym">RPS1</name>
        <name evidence="9" type="ORF">CLCR_03043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D257"/>
    <dbReference type="STRING" id="86049.A0A1C1D257"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03043"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04890"/>
    <dbReference type="eggNOG" id="KOG1628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="6">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="257" mass="29146" checksum="3F991E841986ACA7" modified="2016-11-02" version="1">MAVGKNKRLSKGKKGLKKRTQDPFTRKDWYSIKAPSTFNQRDVGKTLVNRTTGLKSANDALKGRIFEVSLADLQNDEDHAFRKVKLRVDEVQGKNCLTNFHGLDFTSDKLRSLVRKWQTLIEANVTVKTTDDYLLRLFAIAFTKRRPNQIKKTTYAASSQIRAIRKKMTEIIQREATSVTLAQLTGKLIPEVIGREIEKSTQGIYPLQNVHIRKVKLLKAPKFDLGALLGLHGESGEDDQGRKVEREFKEPAPLESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2F8</accession>
    <name>A0A1C1D2F8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps30a</name>
        <name evidence="5" type="ORF">CLCR_11451</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2F8"/>
    <dbReference type="STRING" id="86049.A0A1C1D2F8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11451"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05002"/>
    <dbReference type="eggNOG" id="KOG0009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT54911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="95" mass="10226" checksum="DC48617A9EC62013" modified="2016-11-02" version="1">MGKVHGSLARAGKVKSQTPKVEPQEKKKTPKGRAKKRITYTRRFVNVTMTGGKRKCTEQKRHDADFERAVARGGGGGGSGSGSMSLASYGFEVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2Q1</accession>
    <name>A0A1C1D2Q1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DltD N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_03016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. FUS2 hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2Q1"/>
    <dbReference type="STRING" id="86049.A0A1C1D2Q1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03016"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05101"/>
    <dbReference type="eggNOG" id="ENOG502RYKB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF9">
        <property type="entry name" value="POLYKETIDE TRANSFERASE AF380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="34"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT55011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="317" mass="34833" checksum="A163D89DACE41460" modified="2016-11-02" version="1">MGRENVEFKTSDRVTLRGWFYSSGDAASGKAPCLVMSHGFSALKEMDLDAFAEYFVSKLPIGVLVYDNRGFGDSDTAPGEPIHEIVPMVQCSDISDAITYAASRPDVDPDKIAIWGSSYSGGHVLYVGAVDRRVKAVLSQVPCVSGWDNFNRLVRPDFAVGFNATFAADTPSTLLIKLIDRAARAEGKEPGYVPVVDADPQKPSALPTPDSYEFFSSWEKKSNWKNDVTVKTVELFRAYEPQQLIDKISPTPLLMTVASGDVLTPADLALRAYSRANEPKQLQLLPCGHFEAYTGPYFERNATTQAEFLKKWLVEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C680</accession>
    <name>A0A1C1C680_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chitin deacetylase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cda1</name>
        <name evidence="2" type="ORF">CLCR_00117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C680"/>
    <dbReference type="STRING" id="86049.A0A1C1C680"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00117"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="80"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="331" mass="37874" checksum="9B623CCBC771FB41" modified="2016-11-02" version="1">MPESATPYEWDDHYDFPRNLVGYGEKSHNPQWPNGAKIAVSFVINYEEGGENTVLNGDPHSENSLWEAPGAPPYMGERAINIESEYDYGARAGVWRLFRLFAKHQLKYTLYAVGRALELNPAVARYSASNGHDIASHAYRWIDYHTVSAEDEKAYIRKGIEAIKTTSGFYPKGWYYGRLSPRSHALVWDVFRELNLPLLWESDSYADDIPYWVDVPAEKDSADPQGMLMVPYSYDCNDYKFYVNTGFGAPMDFYDHIKGAFDVLYQEGCDGMPKMMTIGLHCRAAGKPARFAALQKFVEYITSKEEVWVATRTEIAEHFRAKFPYRRGQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C689</accession>
    <name>A0A1C1C689_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">lys2</name>
        <name evidence="20" type="ORF">CLCR_00546</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C689"/>
    <dbReference type="STRING" id="86049.A0A1C1C689"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00546"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01002"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="19">
        <location>
            <begin position="859"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCT44063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1430" mass="155865" checksum="96FC740966427454" modified="2016-11-02" version="1">MDPGKISQGALDWWAHQLQDQTISPLTRDYPEATSGNVPKRPIEAVESLSAPASTTNALKALSSLGSVTTIVQTALIILVSRLTGDEDISIGTNASLNAPSFVLKACVTASESFSQLAKRVEELCTAAADRIVPLDAIQKRLQRPILFRFAALNSDIDGAAARGGAETTDFLLTYYCSPTGGLRLTARYNQRLVSSNRIACVLAQLTKLLENAAVDSNAPVGGIPFTTAEEQAFIPDPTSDLEWSSFRGAIHDIFAANAEAHPDRTCVVETKSEDTPERKFTYQQIHEASNILAHHLVQSGLERGDVVMIYSYRGVDLVVAVMGTLKAGGTFSVLDPAYPPDRQIIYLDVSRPRALVIIDKATQDAGELSEKVRGFINDNLELKTEVPALRLQDDGLLEGGEVNGEDVFQAVRASRARSPGVVVGPDSTPTLSFTSGSEGKPKGVRGRHFSLAFYFDWMAKTFNLSERDKFTMLSGIAHDPIQRDMFTPLFLGAQLLVPSKNDIQNELLAEWMREHGATVTHLTPAMGQILVGGATARFESLHHAFFVGDILIKRDCRSLQNLAPNVRIVNMYGTTETQRAVSYYEIPSRNERDGFLDGMKDVIPAGRGMYNVQMLVVNRFDRTKMCAVGEIGEIYVRASGLAEEYLGTPELTAKKFVNNWFPGHERGLALDKARFEEKYKNEPWAKYYLGARDRLYRSGDLGRYTPTGDVECSGRADDQVKIRGFRIELGEIDTHLSQHPLVRENVTLVSRDKFEEQTLVSYIVPQMNAWTQFLSEKGVEDVPDDGTLFGRVERFRVLQKEVQEYLRTKLPAYAVPSVIVPMKAMPLNPNGKIDKPKLPSPDMGMLSARTRRKSSILHQLTEGELALAHIWAKLVPGLIPKTVKPSDSFFEIGGESMKAQQLAYQVRRTLGVNLAISKIYNRHTLKEMAAVIDNLRAADSLEGGDVVDTNGAETNGVKAAEEYGDDAPKLAKLLPASFPTASARVPPAPVVFLTGATGFLGSYVLKDLLDRQNPQVQKVIALVRAKDEATAISRVKTTCQAYGVWESSWESRIQCVVGSLGPPHFGLPDSQWQQIVSEADVLIHNGAQVHWINTYATLKAPNVMGTIEAMKLAAEGKPKLFTFVSSTSVLDHEHFVREAERIIAAGGEGVSEDDDLAGSRTGLGTGYGQSKWVAEYLCREAGRRGLRGCIVRPGYVLGDSHTGVTNTDDFLIRMLKGCVQLGTRPNINNTVNMVPVDHVARTVVACAFHPPKVASTGGAVKAAAAAARGGGGGGGGVSVAQITAHPRLRFNQYLATLQTYGYEAKLTDYVPWASSLEHYVSSHEDFALMPLFTFVANDLPGDTRAPELDDTNAERALYEDAKWTGEDVSAGAGVTKREVGLYLAYLVEIGFLPRPGGKGGAGVKTLPQVKVGEEQREAMKRVGGRGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6Y1</accession>
    <name>A0A1C1C6Y1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6Y1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00676"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01136"/>
    <dbReference type="eggNOG" id="ENOG502QVG4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="38139" checksum="A582BE97E0C7355D" modified="2016-11-02" version="1">MEGRTFKHLTPEQVDSFMKHGYLRIPGCFTREVAEEWTKNVWVRLGFDPKDPETWTTERTNMPSHEEVAIKDFAPKAYDAICELVGGEDRITEPSKVWKDSFIVNLGTKEHFGQEAHPKELTGWHVDGDFFVHFLDSPEQGLLVIPLFTDILPNGGGTWICSEGVEKIGKYLYEHPEGVLPRMTPIGGGSKNYEDGLEYYNTLVQSCAESSFHEMTGSVGDVILLHPLMLHSASKNGRRLPRIITNPPVSLVEPFNFDREDESQYSLVELKTIQDIGGQEKLRGWKIQGKRAEVVPERVRRQARMLEEEKRRLKERELQAEQTQTQLPRPVPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6Y3</accession>
    <name>A0A1C1C6Y3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6Y3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06407"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06988"/>
    <dbReference type="eggNOG" id="ENOG502T8NT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4153969at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="142" mass="14784" checksum="C24A838FDCE21F2E" modified="2016-11-02" version="1">MSGAFTMPHALTGGAGYKANQTYDDFLRKHSGFYRRHSAASSAMEGDRRASQAALDDNAAAAAEAVSNVAAANANRRASVTVAEGGAATANARKGSVAVASDVTRKDSIFGLEATGGRRMSEERRPSTSLASDLLHKMKGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7S8</accession>
    <name>A0A1C1C7S8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dephospho-CoA kinase CAB5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CAB5</name>
        <name evidence="5" type="ORF">CLCR_06177</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7S8"/>
    <dbReference type="STRING" id="86049.A0A1C1C7S8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06177"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07200"/>
    <dbReference type="eggNOG" id="KOG3220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001227">
        <property type="entry name" value="Dephospho-CoA kinase CAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="284" mass="31775" checksum="89702214C1DC0200" modified="2016-11-02" version="1">MRVIGLTGSIATGKSTCSQTLSSPPYSLPLVDADLLARKAVEPGTWGYRRIVSTFGPTTPDLLLPPSDPLCEGKEDGPNGKGRPLNRPALGRRVFGSSEERTRDRKKLNAIVHPAVRFLMARAMLYYYFRGHWAVLLDIPLLFESGLDIFCSTVVVVAVSDPKIQMERLRARDPHLSAEDAENRVKSQVDVREKAARCKRRNNGKTDAGKGFVLYNDGSKEDLKLQIADMMQKVKSGSPRWWSLLLLVCPPLMATVASWEVLWNWYARRKTIKERGAELAKPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7U3</accession>
    <name>A0A1C1C7U3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_06519</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OST4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7U3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06519"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07278"/>
    <dbReference type="eggNOG" id="ENOG502SZVF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2124077at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018943">
        <property type="entry name" value="Oligosaccaryltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051307">
        <property type="entry name" value="OST4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036330">
        <property type="entry name" value="Ost4p_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10215">
        <property type="entry name" value="Ost4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103464">
        <property type="entry name" value="Oligosaccharyltransferase subunit ost4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT44604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="59" mass="6300" checksum="5D8F780438ABDFAE" modified="2016-11-02" version="1">MITDSQLYSLAIFLGSAAMLLIVLYHFLEVNAQDDEVSSDLKDEKAGVGAVKPVGLESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7Z8</accession>
    <name>A0A1C1C7Z8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7Z8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06075"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07326"/>
    <dbReference type="eggNOG" id="ENOG502SWVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5367275at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="342" mass="38235" checksum="1D24BA5D3F0C90E2" modified="2016-11-02" version="1">MVLLTSSTVSAIVSGGVVCLFTFLLFLSGYVLQQQSVRSIQEAIRRPPEPQPVPTLPPQFREPENDTFGVVLEKPEGDADSVVGSRGPWADSIQVPVVAATQEQNPRKDSPPQRLAYIFALEEPSHLCSALLFAKQQRSTSRLPKEPSIVLLYPSTWESDSSTLFTSALSFMRDVQELYDVVYRPVQIRDAWNTRALLLGELQWGRWDYDQALYLRSPGMVLDIQSLDTTLASLDTRQSWAPLNPSSGDNPEVLLRTPRGLQSPRGPTRKLVLSAIQQNEEAGENGESAELLRRDSAYVLFDDQHLSVEDQTELYNDLKQQFNKGRRTVCEGSGLLNDTEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C886</accession>
    <name>A0A1C1C886_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_05584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C886"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05584"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07344"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2351791at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF94">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="74"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT44672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="620" mass="67313" checksum="5C6533AEE5132C56" modified="2016-11-02" version="1">MATIDLSQQTPRDSLSSDLQQPKPQEPLPMTNEAQLNMRSTEKEHGHGHSDRQTGVLTGTDIPKWKPNFTETMIMVTLAILSLMVSLDATVIVTSLSTIVQALDATATQGFWIGTSYLLVVAVTMPFTASISDIVGRPQTLFVTVVSFTVGTILCAVARSIGLMLVGRCLQGIGGGGVIIISLVIFSDIVPLRFRPQYVGVLQGAWALGSVIGPIIGGALAHPHQWRWVFYIMLPFCGIGLVCIPLFIRIRRPEATVKQMLSRVDWIGGFLFISSATGFLVAISWGGTSYPWNHWRTLVPLILGILGLIATMIYERFGAKEAFLRHSLFHVKSAHGIYIGAFVQGLVLYAQLYYIPFFYESVKLYSPIRTGVSLLPILLTLIPASVIVGAAITRTGTYLWAIAIGWALTTLGTGLTISWDRSTHTAVWAIELIILGVGHGLNLNALNTASQAVSKPGDEGRAVGMYAFLRSFGMAIGVGVSGSVFQNVMKTKLKDTGLPTDIATNAEAYLLVLKQMGDTPERQAVIDAYVSGFHGVFAFLTALAGLALILGLFIRHHEINKELISEHKIVDAARIGWRHGHSRATSREELITPLRTAMSSAPSFAMDSAMQSREMVAEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8H7</accession>
    <name>A0A1C1C8H7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_05494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8H7"/>
    <dbReference type="STRING" id="86049.A0A1C1C8H7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05494"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07461"/>
    <dbReference type="eggNOG" id="KOG0927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050334">
        <property type="entry name" value="Molybdenum_import_ModC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514:SF4">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="21"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="431"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="669"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="794" mass="86839" checksum="7070FC7B52B7093B" modified="2016-11-02" version="1">MRTTARCLFRHTLRRSRLNLIQIHNGTFYREHPSAGGKDTSTNPPLFPDLRFELPATTRRKGSGQDTERRSPHWAVISGSGDGTTFLEILRGSHLCFPPNARSYPYLAEGDIDDQTDHRLRIPSRAIQYVGFNTKQGGIAGAGGVTGAYLSARYESRREETDWTVLQYLTGDTELNPGEKQQQVDQSLLHKVIADLRLQKLTAMPVSNLSNGQTRRARIAKALLGRPLLLLLDEPFMGLDPPTLVTLSPMLKKLAYRSSPLLMLGLRPQDPIPEWITHLVVLGHNHTVALMGQKDRVLLSVRKWADVASKSHARTQDQSAVVEGILQQYGPPPAGLAGDVLSETGISTASLGIPAEEFPAEEVDSVAGSDRPFKSPLDDILQQLVTSAPSASHGQGSTISMPSSSSDQQRTTRRPTDATVTTNSTAGAPLIELSSVMVKYGSKIVLGNPTGLSLTLNQGMRLALLGPNGSGKTTLLSLLTSDHPQSYSLPIRFFGRTRLPDPSNNMAGLSLWEIQSRIGHSSPEIHAFFPKHLSIRRALESAWAETYAGRPNLTPSRAALVDQVLEWWEPELRPEGPRPWPHRNSHDSSSSSSSSSIINDGVGDGNDYYSWATSKTHPFGTLPFSTQRLLLFLRALIKQPDIIILDEAFSGLSARTRDKAMAWLEFGASSSGSSEFTPRHQRSNASTASIHSDEKTRVVVDGGGGGTQTSSSKTDTDTDTDDEMTTTTFRGLTDRQALVVVSHVKEEIPDCVDEWLRLPGEEEITESGRGVEGGKTPHRGWVKSPEGWMKVWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9A8</accession>
    <name>A0A1C1C9A8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">aldA</name>
        <name evidence="11" type="ORF">CLCR_05795</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9A8"/>
    <dbReference type="STRING" id="86049.A0A1C1C9A8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05795"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07740"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000011">
        <property type="entry name" value="ALD5p Mitochondrial aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="10">
        <location>
            <begin position="26"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT45067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="496" mass="53785" checksum="360710AE39FECAEF" modified="2016-11-02" version="1">MSLTQKIETPSITYEQPLGLYIDGKWVKGVEGKTFETINPTNEKPIVAVHEAGPEDVDIAVKAARKAFNGVWSQTLPSVRGQMLTKLADLFDEYSDTLAAIESLDNGKALSMAKVDVQLSSGCLRYYGGWADKIHGKTIDTDPESFNYTRHEAVGVCGQIIPWNFPLLMWSWKIGPALATGNTVVLKTAEQTPLSGLFAATLVEKAGFPAGVVNIISGFGKTAGAAIASHMDIDKVAFTGSTVVGRTILQAAAKSNLKKVTLELGGKSPNIVFNDANIEDAISWVNFGIFFNHGQCCCAGSRIYVQSGIYDKFIQAFKERTSKNVVGDPFKADTFQGPQVSKLQFDRIMNYIQSGKEAGAKVETGGERHGNEGYFIQPTIFSNVSEDMKIMQEEIFGPVCSISKFETEDEVIKAGNETTYGLAAAVHTQNLNTAIRVANSLKAGTVWVNNYNMISYQVPFGGFKESGIGRELGKYALANYTQIKSVRVRLGGALFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9B8</accession>
    <name>A0A1C1C9B8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9B8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06186"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06025"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="282" mass="32769" checksum="45060697AD1AC6D9" modified="2016-11-02" version="1">MATLPDKEATKGRMLHELVNKVEFVVAHHNEDLSWLSDVEELTSVYSKGSRKIPIFPRRQTVLPNIGREGHTYLHHLITQYDNLADIVVFCQGQIDDHVDLSASQIWSAASMLGDDQIMTFPPFELEHFDVWTGKHVDLYPVEHVWPEETFREPRRDVQMAPLRPCEYFRRFIGRGKIPLSIAWQPGAIFAVSRNLIHRHPPDFYQELLNAFFGGVNATHDPETGHILEKFWLSLWMPEKYICWKSEEISDNERNEQGQLAKGRWNVRLSCIRNEPTVMGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAB1</accession>
    <name>A0A1C1CAB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AdoMet-dependent rRNA methyltransferase spb1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">spb1</name>
        <name evidence="13" type="ORF">CLCR_05471</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAB1"/>
    <dbReference type="STRING" id="86049.A0A1C1CAB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05471"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08037"/>
    <dbReference type="eggNOG" id="KOG1098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="234"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="618"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="332"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="407"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="361"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT45407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="833" mass="94398" checksum="FA7FAA6170BBE461" modified="2016-11-02" version="1">MAVQKKHGKGRLDKWYKLAKEKGYRARAAFKLIQLNKKYGFLEKSRVLLDLCAAPGSWCQVAAETMPAQSLIIGVDLAPIKPIPRVITFQSDITTDKCRATIRSHIKHMKADTVLHDGAPNVGVAWVQDAFSQAELVLQSMKLATEFLKEGGTFVTKVFRSKDYNALLWVFKQLFTSVEATKPPSSRNVSAEIFVVCRGFKAPKKLDPKFLDPKHVFAEIQEPTPNNEAKVFNPEKKKRKREGYEEGDWTQHKEVPVSEFIHTTDPIAILGSVNTLSFEQPPNGDLALTTIDRLPETTAEVRQCCADLKVLGKKEFRTLLRWRLKVRDKFGMSTKAKKQQAKEEEKDQEGEEVAEVESMDEELKMQEELQRLRHQDSKEKKKERRKENEKKRKEIVRMQMHMTAPFDIGLEQNGPAGEGSMFSIKTAERAAHPPRIEDEEMADGDGGQSEFSEVETQSEDEDEDEVGDRLERELDMMYESFQQRREEADAKARAKRARKERETDEWEGLSDEGDRTDNEPTDVETDAEDDYAMREPPRQEGLSNKAAMFFDQDIFQGLGIEDDEDDNDKDSAIEMDDESSDQAKPPVATVQNKASEGAQKSKPLKSALKQAQSMRAEDSDSDSEPEKRTASAPRAAEDPLTPSGHLDIDIITAEAMTLAHSLATGEKTTRDLLDDNFNKYTFRDVDGLPDWFLDDEDRHSKPQRPITKAAALAIKEKLRALNARPIKKVREAKGRKKFKAAQRLEKLRKKSALLLEDEGMSEKDKASAITRMMSRAAKKSGKPKEKARLVVARGVNRGVAGRPRGVKGRYKIVDPRLKKDVRAEMRLKKKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAT4</accession>
    <name>A0A1C1CAT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_01443</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAT4"/>
    <dbReference type="STRING" id="86049.A0A1C1CAT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01443"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03505"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF5">
        <property type="entry name" value="GABA TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT45596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="580" mass="63752" checksum="271B60D8A8B99835" modified="2016-11-02" version="1">MDSHEISKGTDVSVDDVPPQDAKTGSYEEEKNVSQAYPATTREGDGRSLRVPPLPFFAPSHVPFQTLAKHNYLLYDVGSDCPHQRLFSFAQLLAFSLTFMESWEVMAINISATFWNGGPRSLVWGAIAVIIGSLAQAYSMAELGSILPIAGAQYHWTHIMAPERSRRFITWMQAGWVTWFAWVSALAGSSSGEAALLQALIAENVPGYDAKRWHLTLIMWALLISSGLINTYTFWLVPWLELASGIMHVLLFVVFMIVLLVLSPKSSTDFVWSSSSVLSGWDRSSFVAFNLGMLVPAWGFIGFDGVVHMSEEVRRAKHAVPRSMVLSIAINGTMAFAIVLVLLYCIGNVDDALDASYPIIPICFNATGSMKATNAMVSSLIILTYFVVAASVASVSRITWAWARDGALPRRLAVIDPKLHVPVNATWLPIVIVCLLALFQVGSTTGTAFSAFTALSSLGLYTSYIIAISCILHARLTGRLSDDDKAPNHQDAQAQVSYGAWRMWPGFATPVNVFALLWTVYLTVWLPFPTSLPVTGTNMNYALPIYAFVVLLALGSWFVWGQRHWKGLDLRAIGMVEAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB52</accession>
    <name>A0A1C1CB52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB52"/>
    <dbReference type="STRING" id="86049.A0A1C1CB52"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01410"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03589"/>
    <dbReference type="eggNOG" id="ENOG502RYID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3034003at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="714"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="862" mass="94118" checksum="9BB29FC1A8FCF9EB" modified="2016-11-02" version="1">MLTIAEVSGLIAAAVMIVQYGLPAALVVILVKYVGTENTAVTWSVVNRTISTTIWPHLLRTDAANTRQVPSRVQIPSWAATAGAALLVLASVVTPLGLYDEIVPGESTLVEFQYVKDPGPWGRVTMPRPDAQFSRQCEVGTVINCPGQYQGVYMAETEPGVWQSMETDENSTINITIPENFTTMFTSATSDQGNTVSGLFDIQYRRWKFNQNGLINKGQPYVRGDSRTIGTLITQERILLTEGLIVDVRDNPGIGFRNHTIPVGLEHGGTWTEDITWIEPVTKCADTNLSIELRIENTVDDFSNQNTFSVVDRGAFFGLDVTALESRAWIDNQTLDLFGRAHKAARMHNVLVASSLNISLPLDQNTKPLPKIPVTDTGSASPGMFSMSSFDTIVLDQMRGVGGAPPEVPEYSGGNTSIPFVNHYPDGFKKLLALNYSAIAQICRGYYEIGATDNDWRANNITYPAVQCGSVLGTPLQPPNQNISASTYTGIETYQKNLYICASAVRASIKTVTFRYNGTGAQFGNLEAVHIADKVYADEMSKPLWAAEHSYDRAMRFDPLWGIVDNRYHTMGYKDGFYTLRAEKLWLPTSPFLTGNFGESEGYDALAAASGFTRRLGNLYGGLSDLAGPDYSGQHDYTLLERYQRLSHDATNAAQIPSLKMTDGLAAGLVGTKTSVSTKYVAWPASLAVDDTASGFPRASVVEYRRVIRYDIRYAIPAFVMLALLLVALVWALAILCSSRHTLRTLRNMYNQTSTGRLAVNILRPGQGDAQQSSREWVRQDGALALRFGQINVPGGDDFCTVVGGCDDAKADFCPKDELCQRAYDGGNSVPRRPSSDIPPGGKKGVAETSITVIPKQEITGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBX5</accession>
    <name>A0A1C1CBX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FMP37</name>
        <name evidence="10" type="ORF">CLCR_00491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBX5"/>
    <dbReference type="STRING" id="86049.A0A1C1CBX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00491"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10041"/>
    <dbReference type="eggNOG" id="KOG1590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:7770001">
        <property type="term" value="C:mitochondrial pyruvate carrier complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050833">
        <property type="term" value="F:pyruvate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT45969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="148" mass="16644" checksum="199B34E94DAA8B0C" modified="2016-11-02" version="1">MAATIKAINARIRSNKVLDYFCSTHFWGPASNFGIPIAAVLDTQKDPEIISGKFTAALTVYSGTFMRYALAVTPKNYLLFACHFVNFNAQLTQGYRWYDYWYGSGKEKWAKVRAEQAKNELEGTVDNLASQTKVKVQDAVQEVKKTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD94</accession>
    <name>A0A1C1CD94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynamin-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Scaffold protein Tuba</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_01780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD94"/>
    <dbReference type="STRING" id="86049.A0A1C1CD94"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01780"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01229"/>
    <dbReference type="eggNOG" id="KOG3519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="8">
        <location>
            <begin position="1163"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="662"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="751"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="799"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="947"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1022"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1701"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1820"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="127"/>
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        </location>
    </feature>
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    </feature>
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            <end position="402"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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    </feature>
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            <end position="567"/>
        </location>
    </feature>
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            <begin position="587"/>
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="751"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="806"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="854"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1044"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1080"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1121"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1752"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1820"/>
            <end position="1831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT46500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1933" mass="212857" checksum="342321A55915C74D" modified="2016-11-02" version="1">MPSAVSSHGNYYSAHHRRQSSQSQTNLPDQLRNSGLPAQSPNRSLVFLPSTAYSPSQPITQRSRTSSLSTPSRSASRLDTVRIEEIPNDPHDFYRQYQDPFTNASPVALHQEAIRTAPIEPVEEVPVSDRKPSFNADERTPKTARNGAGGRKLSLTTQTLPNGAFTGSSSKPAPAMPNGLRSRKASFKDLVARFDASSDDIPPLPSQPISRPASRTASPMPYGSVDTSHSFQPPMKRPPSRTSESTRRPGSAVGLRTPSNDRTVHSRGASAAGGLSQVISNPEAPADGRKLLFGEVAPSASDLPAAPGYGIHNARLRRGSEGSSMRSPNPMFQTKRGQAHLPGPPMSPSAVHPPSTVLSNEAQSQRRPAHRRANSDFSGPFSRAVTRDGRTSSSSTGTNGHRNTADATAKSRIPVSTRHQRIASDSAAISPTTPPTIVPHHQLPFRVLESGRKPSSPSHSRDRRQQSPHRQVRSPVQIKSPNNRGRGTTTANGEKSPSLRANIIAPPPKVSPPLRSSRPRMPVSSATTAASRAKMAEKFQTMAKQQSDKKAFRRQRPPELSDIDLKARRLKITQALSRSREGHDLKGGTTSAQGGSSSRSDSMTPSFEESDETEQHPHEAMEIPAVVVNEPAVDTSDERAFYSALGESPGDQQAFTQNALRVVESSSSHPGDDLDSPTLGHTDSPFSNIPFSLNTHLQPLRDEQEPQSAMTEGTVATEATMIDVEPQTDTSRLQTPGQSLYSQISILRSQESTSPLSSASQASGENTDHADQVSVHLMLRNTTYLDDEEAVEKGYRHLAPLPQPELTPSRSDGGNSWTSSIEDSPDSEVDEGSASVTHSLRRQEAGSAGVDSGSHFESDHSSNEDESGRDHHAADAYTIVNKVLQQQTQSGVVDQQLVDDIYHRIIQASPDLADVENVDEEKVQHLCLHELDEYTRQWEQLESSPWRSSKSLHTEEPMASVHQNNEAQGDNAGRPADIPMSNLETSLPPPSSWKAHHRYKSSLDSPQDWAETSPSVGDWMQFALKSPAEQRQPSGLAHEAYANEGSTLPVSENVQDLHQDDDEQEKLMFVPMGAERDIPRPPSHSPPPPPPIAKLPTSDQSSWSAPVGIRPAVPQVPPQSRPQTSFSQVSARSSMDQQPRPSVSSNTRPSVDEESPEQRRLKKRRHILKEIVDTEYTYERDMRVLCDIYKQTAVAAISDDDIKIIFGNVDLVQQFSKDFLAYLRQVVKPAYVMERSDRRKDADRASTVQSSAASIGGALDLTDGEKDELTRVGTAFEASMDDMEKVYTDYIRTRHAANKRLEVLQASPTVKEWLKECSENSSDITNAWSLDALLVKPIQRITKYPLLLNQLLEATLDTHPDVEFLRRAASEVTEVNVRINEVKKHTELVDQVLNRKRKESDVRNGLTKAFGRRAEKLRQHVGINEMYEDQEYAKIKISYDNNIAHLFLVTKDCQGYVEAITRWVGRLCELAAAAEAWVDVGHTNHSQAESKLRQFAIVVRGINSIALPDHSEQVSKRVIQPMDKTAAMLEKFKADTKGLIQKREKRLLDYNQFKNKKDRGEKIDKKMTERMEQWEALNLEAKERMKRLLRSTADLVHACQANLIQLHLNWLGMCRQKFSAAIDIPLDKVDNSDIVKDWQEDFDYQEATALTLSICNGSLLAEAVNMISFLTPGSTLNGEESPRQPSWNSMKRAISANEEIPPFPIKDHHHRNSGGPMSSQSDDRTEWSYSTFANGRIRTGSAASGRPPKTPETASRGVSASLHTVDSLNPSRPGTSPGLPADSAKSAPRLSLEAPSPSLGELLTESSVALRHVSTSSFYTAAPGPSQSQPHLPTPGGASVFSSAMPMEDIPRPTRATPQPREVPGVLFTAASVYEFNIDRSRQQGGFRYLTYVTGEIFDIIAEHGELWLAINQDDPTREIGWIWNKHFAKLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDG3</accession>
    <name>A0A1C1CDG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11251"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01267"/>
    <dbReference type="OrthoDB" id="10655658at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="253" mass="27381" checksum="9FF4821B25472597" modified="2016-11-02" version="1">MHHGTRPFHPQGWEPLVGVGKGHKPPDVELKPGGERLKSSLPLVSEVDTPLENVEGEVLPRAVVGLVPLLGAGLELDVVAMRDEAASGGLLDDDTRAVMMVLMTVTNVVDDQSTVPVNVENTFEKEVEPDSPTLEEPDIVEVDDTVDNVEAEPVDKEELVPEADDGVEYGGPVLGDWRLAVLAKLDNVEGEPWLGVAEIDVQAEEEADDSAETVLLVDGVQLGEETVEVKRNNTVANHSWTIASKTERIYLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDK6</accession>
    <name>A0A1C1CDK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-terminal kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Scyl1</name>
        <name evidence="3" type="ORF">CLCR_01833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDK6"/>
    <dbReference type="STRING" id="86049.A0A1C1CDK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01833"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01343"/>
    <dbReference type="eggNOG" id="KOG1243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="740"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="798" mass="85819" checksum="DB48039084CB96EC" modified="2016-11-02" version="1">MDFLKSAVASAIAKSSSFPVTIGDRVDIGDSIWTVHNGIKKDDGSACCVFNFDINANKSRLPLAKNAARKLRTLRHPGVIRVIDVIENETNIYIITEKVTPLGWHVRRKSLSDETIKWGLYSVSSTLKFINNDASSVHGAVRVSSVFTSESGEWKLGGFEILSSMNEDDAIIYNYGSLLPDSNRYAPPEVVNSGWSAIKKNPLGAPDAYGLGVLIFEAFNGSFMGNDQLGQPRSIPADMVQSYRRLINANPKLRSNAGQFVDLGKKAGGFFETPLIHITEGADSLGLKNEQERDEFLGELESLTDDFPEDFFKMKILPELLKSVEFGGGGPSVFGAIMKIGLKMPDDEFESRLGPVIIRLFNSPDRAMRVCLLDNLPLMIDRIPQKDVNGKIWPAMTGGFTDGAPIVREQTVKAVLSVISKLSDRVINGELLRLLAKTANDEQPGIRTNTTICLGKIARNLGVGSRSRVLIAAFGRSLRDPFVHARSAALQALNATIDVFSDDDCATKLLPAICVSLVDKEKLVRDQANKTVDTYLNKVRKYAATMPETALPAEQGPGTTTSAAAAPARIGNQSDTTWAGWAISSFTNKMAGAKGEMAPAATANGAPLLQTQSLPTSGRTTPTINVIREKSTATSSRLPTSQTTSMPIPPPEQAEDAWEEEGDTLDAWGTMDDEEDSFFDAPSATKSSTPEPAAAFDDGGEPDFAGWLAAQSKAKSQKALPKGLAKSTNAASTLNVRPIAPARSASAGVGASSASSKRPAVTNTKTIAPVTAKKEIKKEIPKLKEPSVNDDDWGEAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEK9</accession>
    <name>A0A1C1CEK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02550"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02521"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF5">
        <property type="entry name" value="PIMELOYL-[ACYL-CARRIER PROTEIN] METHYL ESTER ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="319" mass="34777" checksum="0D27FB8E8AC15421" modified="2016-11-02" version="1">MSPDFELKTTHSKDGTKIAYYQIGTGPGIIILHGGMQHALSHADLATSLASHFTCYLPDRRGRGRSGGPIKHCTYTPQKEVDDVEAIHAASGAKFIFGVSSGALLTLKAARAAPPSHIAKIAVFEPPWWPESEREAQMAWIARYEAEVERGELASAAVTAMLGAQMGPSILQSKYFPRIVLVVLTKLMMRFERPVGLPNDNRGTNTAVTQQGLSFKDLVPTFCNDIKIALDMLGEQNLQALSAIQTESLILGGTRSPAYLQRSVREIDKILPNSKRVELQGIDHGGTFNKQQGGSPEVFAQELRRFFSGCHETQMSEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CER2</accession>
    <name>A0A1C1CER2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-formylbenzenesulfonate dehydrogenase TsaC1/TsaC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tsaC1</name>
        <name evidence="3" type="ORF">CLCR_02478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CER2"/>
    <dbReference type="STRING" id="86049.A0A1C1CER2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02478"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02481"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_6G09140)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="256" mass="27112" checksum="17B1E04E7ECF415B" modified="2016-11-02" version="1">MGCLAEKVVVVTGAGAGFGRGIVQRLTAESATVLAVDVNEEANEETRSLCSLNPGAVGTLKADVTQLSAWQSILSEALSLGNDRLDVVVNCAGVVHLAGPSHEMAEDEFDRVFRVNVKPLYLSTKVIVPWWKEHEKKGLFINLSSISEPRPRPNLVWYASSKGAVTVATKGLAAEYAADGIRYNCIRPAVGETAMLGRVLGGQDTPEGRQKLLGTIPLGRVCQPADVANMVCFLASDQAEFITGAAFDVDGGRGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF09</accession>
    <name>A0A1C1CF09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="15">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">rat1</name>
        <name evidence="19" type="ORF">CLCR_02243</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II. Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with RAI1; the interaction is direct, stabilizes RAT1 protein structure and may stimulate its exoribonuclease activity. The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="15"/>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF09"/>
    <dbReference type="STRING" id="86049.A0A1C1CF09"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02243"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02333"/>
    <dbReference type="eggNOG" id="KOG2044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051984">
        <property type="term" value="P:positive regulation of chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180037">
        <property type="term" value="P:rapid tRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="111"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="422"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="520"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="893"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="927"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="967"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="978"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1001"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="1040"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCT47089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1054" mass="118469" checksum="8A3F0C13081F4F4E" modified="2016-11-02" version="1">MGVPALFRWLTRKYPKIITPVIEEQPVDIDGVKYPVDTTKPNPNGEEFHNLYLDFNGIVHPCSHPEDKPPPANETEMMLEIFKYTDRVVNMVRPRRLLMIAIDGVAPRAKMNQQRARRFRSARDAKEADEKKAEFQTLLRQQRSNNDDDDDDDEADTVEEVVKKTWDSNVITPGTPFMFILAQSIRFWVQWKLNTDPAWAQLKVVISDASVPGEGEHKIMQFIRSQRSDPAYDPNTRHVMYGLDADLIMLGIATHEPHFRVLREDVFLNDAKARTCRICGRQGHYAENCRGEAKEKSGEFDEKGTVEKLKPFIWLNVPVLREYLGAEMFVPGQTFRFDLERALDDWVFMCFFVGNDFLPHLPSLDIKEDGIDKLIAIWRDNIPLMGGYLTCDGKVDLARAQIILQGLAKQEDAIFKRRKEAADKQAIRDQRRNDANKARDARNNKRRRSSPDYTKGSRVAVDARVPTGMQTFEATNFPTLDYNSIVNRGALDKTLTSNKSAAAVLKEQMLARKAAAETATKDAADGANGTPGSAGAVLGKRSASQMEAESDDPGTPASALGKRQAALMDEEPETDGTPGRNTPIEKKTFNNADPNNPPPDTVRLWEEGYSDRYYEQKFHVSPHDTEFRHKVAEAYVEGLSWVLLYYFQGCPSWTWYYPYHYAPFAADFVDIDKKVVKFEKGTPFKPYEQLMGVLPASSNHAIPSAFHPLMTEPDSDIVDFYPEEFDLDLNGAKQSWKAIVLLPFIDEKRLLKAMATKYPLLTADEHARNERGHDALLISEQNPLYEQLALKFYSKKAKDAPKTVKLSMQKFQLAGDVIKNEDFLPHMDLVGPEPGIRLDPDVDDDRSMSVFFVMPPPTHVHKSMLFPGVVLPPAVLDKSDLAILRSKARVSGRDFGGAPLYDNTRRDPMDNQNRGGRINYAADRPPLNGPPMMPPPNQWPPGMPPPPPPNFGAQNAYNRGPPPPSNGYPGYNNYANQGYGGYDQGQNGGHSQNGYYGGNQGQTQYGNNGHYQQNGGRSFSDGNYQGQNRGPPGRDNWSGNHGGNGYNQGGYGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF85</accession>
    <name>A0A1C1CF85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit KXD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">KxDL homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_02644</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KXD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02644"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02244"/>
    <dbReference type="eggNOG" id="ENOG502S1H5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4089816at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051390">
        <property type="entry name" value="BLOC-1_subunit_KXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019371">
        <property type="entry name" value="KxDL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10241">
        <property type="entry name" value="KxDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KxDL" evidence="9">
        <location>
            <begin position="98"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT47190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="174" mass="18880" checksum="287E7AEB548C01A5" modified="2016-11-02" version="1">MATTTYSRHPVSYGSHQKALPVTLPPSGKGPIYTQPISRVADALDFSDSSTSYSSSGRSGGSFSVRSGSSYAGSHSGTDYESHYSRSGIDVVEELSERMNSAFDPLRMDKSLAKQAQTLTMGSSGELNAKQRELQELQAMAQRRLGRARVNFAEGVEAAKEARRDIEYTSKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFM6</accession>
    <name>A0A1C1CFM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFM6"/>
    <dbReference type="STRING" id="86049.A0A1C1CFM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02574"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02123"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="283" mass="30877" checksum="9D8733E7F68B8CF8" modified="2016-11-02" version="1">MASPKVWFVTGCSSGFGWELALLALNRGDRVIATARNASKLEGLKSAGATTMAWDVTAPLAELKKAAAEAHAVYGRFDYLINNAAYNQVGSLEELTPEETQAQFATNVFGLLNTTRAIVPYMRAQRAGVVANFSSVAAWVGYPGVGLYCASKWAVTGLSETLYYELADFNIKVCTIEPGYFRSEFLNPGNLLKRENVIPDYEGTAVRKGEQSMKDYDNNQPGDIKKGVKVIVDVLSGDSGREIPMRLVLGQDAYGMIKAKCEDTIKGLEVWKDLTCSTDLDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG14</accession>
    <name>A0A1C1CG14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitogen-activated protein kinase kinae kinase bck1</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_03247</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG14"/>
    <dbReference type="STRING" id="86049.A0A1C1CG14"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03247"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01965"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1351"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="154"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="340"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="767"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="819"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="944"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="987"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1183"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1229"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1322"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="769"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="826"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1012"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1090"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1109"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1135"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1183"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT47412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1603" mass="173526" checksum="B1A65010B3C6D03D" modified="2016-11-02" version="1">MVSNSQIMDNQRQQYIPGPPPPPGQGTMGHLPPPPPRPYPGSNLPPPPPGPHPSSMPLGTVFGLPGAGWQQPWGRSGMGQNIPPPPPFNHNQPQGQHMPYGMRQLNMPPPPPQNDKPILSATFIPTGDSFGPGVGIPPLDDYASYSRYDAQFTSEPSLSHADQKYSDGTSTSHSYSYPNPTQPNPDIANRESRAASASSNKPSFTLPLRDQHEPISPGPPTATLINPQTVTDGRQRAHSAAVTGSNSSELSSQWPLDRVLIWLAANGFSNDWQETFRVLKLQGSDFLDLGRGPNGRGNLGMMHQTIYPQLAKVCSNSNTGWDQGREREEGKRLRKLISRLVEQGGEGPASAGIGHRRRESGMVPSAGTIASAGTESTLENSPHLPRSEFGSTPGTAGPEGSPGKQMPPQFPVGLGHRTSQPRSSTMPVLSKHSSASSTPSDSKPPENFAATGRADYTRGTLNNLNSRGRHSPNPSGDGSIGLLPKPFEASPNASPGLGSAVPVSATSTSSQSQRPDHSKNNSTDSMLYASGQTRSNTAVESARFYADRRGAQEVTRPSPLEAHRTWSNDYTPGPGGKDHSKGFLSKFMRKRHEHSQPPPDDHPLESPTSPGPWKILSKPSANGSDLALLQRPPSTVSEDERVPVTARRGARVARRYIFVTPDFWNYRLVDVTDVETAIALRSLICIELGIPDAEYAQIFLTEPGQSDHENALSDNALVAVRSRTDPLGSVKLYVRSPTLSAVHGSPSQSMGLGVSFGHKVPVERGTPMVKSNSSGGVSRNGYTSPGAAEALSNDPLLVQKQAEEYRRKTEAQQRAYLESRRAQKEQGATYSGNSIRGNTVIDFDTPRHSPFEEKKVENLVPVRRPPTAPAESTTLTKVNSLRARGSGSRSSLDALKRISDPIAEEDGKLSKKKSATFAPAPAGGIGAALANMGKMSVAPATLASQGLSQDRGRVDFGRNNSGGFLRPDCTRGRSDMLCTIADYEQGFGDLSRDNRPQNAAVENARRFRQSPPVSPSTKSPPRPFLQTRKSYGPDLEFKETNVSFAPSPHPTKDDDSDDDSDDGLFAIPLANKSMSSAGTATPPRIKDQRPTLTVDTDQNTAKNVRFKSPKSSSGMRPTGDESATASGEGYDRSYSDGSFSGSAQSPDDRMSRRDSFISDIWANRPAVENVVDHLDEFFPGVDLDKPYLEEKGDNNSPMRSSDQDPLDALEPRSKGVTFGTAGLDLEFSRKNDSDTLGSDESTLKAKDRSKVASVAQRQVGKSTGGLSRMKSIREVAQKRNDVSIKRGPSVAARVQENNASGIIRRKSTKMFGAHIVQIRPKPGNRLSTLDPIPQEEVPTDDTPKRQATFKIIRGQLIGKGTYGRVYLGMNATTGEFLAVKQVEVNQKAAGQDKDRIKEMVAALDQEIDTMQHLEHPNIVQYLGCERKEFSISIYLEYIPGGSIGSCLRKHGKFEEAVVRSLTRQTLEGLAYLHQEGILHRDLKADNILLDLDGTCKISDFGISKKSDNIYGNDVTNSMQGSVFWMAPEVVRSQGQGYSAKVDIWSLGCVVLEMFAGKRPWSREEAIGAIFKLGSLSQAPPIPEEVQSTATVDGLNFMYDCFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGU6</accession>
    <name>A0A1C1CGU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGU6"/>
    <dbReference type="STRING" id="86049.A0A1C1CGU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03568"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04670"/>
    <dbReference type="eggNOG" id="ENOG502SQMB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="105"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="307" mass="35012" checksum="1240350526FE98D0" modified="2016-11-02" version="1">MSRSERAVPCAQSPSPLPPTFRLRRAGFLDLPAAARTCSLAFDDDVLFGRLIHPYRRSYPADVDKYWYRRFVVDFWDWSHVFLVTTGPDAADKTKEVVTGFAHWSRIAPGRRENFEAGWGLTGLDPRRLLQPLCRLLMRFLAFISPNRAASKEDEFIIERSYNYLDHIWTGERSESWYLECLAVHPDYQRQGQGRALVGWGLQQALREGIACSVIAADGKERFYQACGFNVGPVGRSGEGEGNPLREVPGGLVFFQEKRGVVLPDRDLGSWTYGHGVFDWDDWKKHVEAKRHKMRLLDDLSTASSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGX2</accession>
    <name>A0A1C1CGX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_03669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGX2"/>
    <dbReference type="STRING" id="86049.A0A1C1CGX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03669"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04594"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF4">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="167" mass="18079" checksum="A73A6559E1E6446A" modified="2016-11-02" version="1">MSKILLILGSGVNVGAHTAKAFAAQGYKVASASRTAPKTPDGSHLHVTVDLSKPETVPEVFEKVRQEFGGEPSVVVYNDMLVGTFNKCRRAEERANRTNSSSFDATTPASQPDITSFFLPLLALEDPVTDTDHPPHRVQLRSSAPTHPTFSPSSRPRASATTKRRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH12</accession>
    <name>A0A1C1CH12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase domain-containing protein 2 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fahd2</name>
        <name evidence="4" type="ORF">CLCR_03691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH12"/>
    <dbReference type="STRING" id="86049.A0A1C1CH12"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03691"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04544"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF112">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G02370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="196" mass="21380" checksum="18B1C67A2E28EFF5" modified="2016-11-02" version="1">MALPKAPILFTKPRTALADPYPSVIPVPKAAQDGTSDYEAELCVVIGKSGRDIPEEKALDYVLGYTASNDVSARTMQMLTTQWSFSKGLDGSCPLGPVLVTKDAIPDPQNLKIKAIYNGQTVQDGNTKDMIFPIAKQISYLSQGTTLEAGTIFLTGTPAGIGFFRNPRVVLEDKGDIRIEIEKIGTLINKVRYEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH89</accession>
    <name>A0A1C1CH89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pelo</name>
        <name evidence="12" type="ORF">CLCR_03540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH89"/>
    <dbReference type="STRING" id="86049.A0A1C1CH89"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03540"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04513"/>
    <dbReference type="eggNOG" id="KOG2869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000004">
        <property type="entry name" value="Protein DOM34 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT47836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="413" mass="45545" checksum="7F3A3AC592190A07" modified="2016-11-02" version="1">MRLVKRHIDNDGSGSVTLCPEEPEDMWHAYNLIRPADLLTASAIRRVTTESSSTGSTASQRVHTNLTIRVKSTDFDPQAGQLHVSGQIARENRYTKIGQFHTLDLELNRNFTLEKEVEGDNGGEGWDSVARAQLEEAIDQTRGTEAVAVVMQEGLANICFITQFQTVLRQKVEVSVPRKRTGAGRSADHDKGLQKFFSTVLDTLTRQLQGLMENKDSSSNFPILLASPGFTAAGFLKHITETASAKGDKLLQDLVKRKAFIVIHSSSGHLHSLNEVLKSPEVLVRLKDTKYARETSLMDDFFALLRKDDGRAWYGPREVETCVDKGAVGRGGGVLLISNALFRSQDVATRRRWVRLVDRVREVEGGEVRVLSSDHESGKRLEGLGGIAAILTFPIDDIESDGEDSGEDGSEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHA0</accession>
    <name>A0A1C1CHA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHA0"/>
    <dbReference type="STRING" id="86049.A0A1C1CHA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03360"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04502"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF24">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="184"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="617" mass="69000" checksum="F9F4E51E95057AB3" modified="2016-11-02" version="1">MDGHPLASIPPLTLQEDVNRHEINPGDIVSNWLAALDKRPKNGLSTDLPDLFIEDSWWRDFVGLSWDIATKHGLGSIGEYLNTSTTGFGNLEVTKAGGLQPALVDMHGMIWVQGGFTFKTKDGSGQGLVRLINVSKTQWKAWTVFTQLERLNSQDAIDRQRLKQDYTQTRLSTGVNGGKEEEPQVLIIGAGQAGLTLAAQLKHMGVKALLVDRLPRLGDFWRSRYETVRTHTPIYTDHYPFLKFPTTWPRWLERDKIADWMEHYGQIMGLDYMLSTTVQSIDYDETLRVYTVEVENADGKHTFRPRHLVLATGVFANTPIIPEIPGKETFGGEVYHSMHHKGARHVGPSLSQKRVVIVGIGTSAHDIAQDFVNNGAQAVSIVQRHAIFSLSAKAAEDAYFSLWTQPGVSTEEADIIANSFPTAVVRTLNIGQTAMMEEHDKDLLEGLERMGMQIKKSKKVGYGFIDHLIVRTGHFYVDQGASPMIVDGRIQIHHCEEGVKEFVADGVVLGDGKKVDADIVVLATGYHRNVLTVKELMGDKVADVVGDLGYMDSEQERIGWWRPTGWPGLWYMTGSFVWCRQYSPVLALQITALEQGVNPEYWEQKKRNNKGLGTIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI40</accession>
    <name>A0A1C1CI40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHL4 family chromosome segregation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI40"/>
    <dbReference type="STRING" id="86049.A0A1C1CI40"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04116"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08274"/>
    <dbReference type="OrthoDB" id="6585699at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007902">
        <property type="entry name" value="Chl4/mis15/CENP-N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05238">
        <property type="entry name" value="CENP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="449" mass="50008" checksum="C2B9C5BD22C46FFC" modified="2016-11-02" version="1">MAPILAKSLNRLSREAIIELGLKWLEERCLSSAPYLQCNRTGFEADEEDYLYTPAESIKELRTLYHDLRQHPSQTTKRDVIDRIIDGDWRRGLSLHQHATIDFAYLEQNDAALKWSALKLVPLKSEGEKPVDNDDRDDGQQPAKKKRRLDSGLVEQTYPHVSPEVFLSALKTEISPLVKAHYHVHRMPSPYSLTVLRLWIQPNSAFAPRRSKVPRRPKQATDAGRIMYIALPDSCPYVYISISGSATSSTGRSKGSVRGAKEKVMAKVDMAALKRIVLEAIPKALSRPHQRWALESTNLVAKSLKTMCELRGNQKPGTSGGAYSIFTDSNKAVDNSPVDVHMTAGESELQDDRQGVIEKRFGHTEGEHYAPLDRVHVKLTNPVPPDELGDEDASSSTEDHAKCEITLTFTGSNVFGGLKKLAELGPTYVDLEKMPAWMTGELGVSNLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI92</accession>
    <name>A0A1C1CI92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI92"/>
    <dbReference type="STRING" id="86049.A0A1C1CI92"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04137"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08336"/>
    <dbReference type="eggNOG" id="ENOG502SVZ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="43851" checksum="430D2F0874356287" modified="2016-11-02" version="1">MIPGVFPTRHQAEIQTRWAFQNAAQDPLVLYALLAVASAERSARLGELRNGSIETSFTEADLENRAVPDFVSYKLNAVKLANETMKTMETAAQASTIFAMMCLLSIEVITGNQKEIIAHVSGLQKLIAWRGGYHGIPPHATELILSASYMCAAVTRSLPAAPPTSSLPSLPARLVEEIRQNVSDDVKKMGTGILTPDVDTLLDWRISQAFRDMRDVVQYREYYHEKQELPVQEENDYINARSYQFRYAALSAPFEPRAPASDKEEACRLALLIFWFSNYQVTAPDSALNRTLTAQLKTALQSSDLKGLWGPYFDLLTWVLMLGAFISAGQRERPWFVLNLAKVSKVLRLRDWDELREMLLKFYYLDRIYAKGMRDIWDEASLLAEGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIB9</accession>
    <name>A0A1C1CIB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate permease 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_03864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIB9"/>
    <dbReference type="STRING" id="86049.A0A1C1CIB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03864"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08364"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="565"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="599"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="717"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="725"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="757"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="837" mass="93309" checksum="9886CFB7E77C9B7A" modified="2016-11-02" version="1">MASTRSKVGHGLAKVLGIKLDYRTDTVTRGESTYSVSTADSYVEEEPRSIDWVKDLLPTRQEWFTYVRSLFPFTHWIMRYNTQWLIGDLVAGITVGAVVVPQSMAYAKLAELPPEYGLYSSFMGVLIYWFFATSKDITIGPVAVMSTIVGNVVNKVQEEHPEVPGHVIASALAVIAGAIICFIGLIRCGWIVNFIPLTAISAFITGSAISIAVGQVPTLMGIKVKGFNTRDSTYLVVINTLRYLGHTKLDAAIGLTALFMLYLIRYTLNQCAKKMPHRAKFFFFLSTLRTAFVLCLYILIAWLVNRHHRDKPKFQLLLHVPRGFKHAAVPTINTDIISYFASELPASVIVLLIEHIAISKSFGRINNYTINPSQELVAIGVTNLLGPFLGAYPATGSFSRTAIKSKAGVRTPFAGVITAIVVLLALYALPAMFFYIPNAALAAVIIHAVLDLPTPPNVLYQFWRVSPLEVIIFLLGVFITIFSSIENGIYTTISVSAAVLLYRVVKAHGHFVGKVKIHSVIGDHLIEDKFHDQPKHSDAAERNIFLPLDHNDGSNPSIHVESPYPGIFIYRFSEGFNYPNASHYTDYLVEYIFEHTRRTNPDSWPRPGDRPWNNPGPRRGKTEADRSHLPTLKAVILDFQAVNNVDVTSVQDLIDIRNQLDRYASPEPVQWHLANINNRWTKRALASAGFGFPTVPQQEIHRWKPIFSVAEIGGSESAAEAAEAEQNRRLSRHGHDEEHGRPRSRSKGEDITQAGRYQDDSHSSTSSHDNDLAKEITHSKAYARASVKKVAVVHGLNRPFFHLDLTSALQSAIANVEHQDKLRRVEAEQTEETNDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ87</accession>
    <name>A0A1C1CJ87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ87"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04464"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="89" mass="9994" checksum="D5C58ABD7404FD65" modified="2016-11-02" version="1">MKSKCDDTAPRSTYNGRSSSGKIQHIMSPERANTASNIAKSYWEMVESSDLKLRDEHAVKLTQEGHTELQYCVDEKAAFGNPQTRKACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJT9</accession>
    <name>A0A1C1CJT9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ZIP4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJT9"/>
    <dbReference type="STRING" id="86049.A0A1C1CJT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04716"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03186"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013940">
        <property type="entry name" value="Spo22/ZIP4/TEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08631">
        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="47604" checksum="2F31DCEDB5D4E38B" modified="2016-11-02" version="1">MLPTEPAGPAQSILEFAIHLEHFLDEANPGAQHLPDLSSYLTVLPLRRKDLSPELRIDFDRAAVTLWNKCCSLDGSDESQWMRGDLAKVRAFSYFLLESAGSIKRKNHARLFKIAIKASKSCLDAGLLDIASAIIEQLASKQERLAKSDDNDAPSGGGFTESLQARYLLLRVALVWRQNRLDLAEHFYINQLEQLRPNLSPEQIEELADLCYEIGVDQLNQKQAGSAAKWLRRGCKMLTEHSSQMSQVDIAELRLSLMHSHVRALLASDDLEDRDEAMEALKALCQVSNSPCLPIEWPELIEPGVSSQACRNPASVGGIRKRPNRKSSRLSVRVLHYLHHLKRLSVASAISVLDVYIVTRLAPDGEKEWTEGTIITLIWLMTSDGTDGIQPKLPDFAESFDRIFQAWGTVLSAEATRGVLVVGASHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK10</accession>
    <name>A0A1C1CK10_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK10"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04908"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03048"/>
    <dbReference type="eggNOG" id="ENOG502T7WI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4120788at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="432" mass="47906" checksum="7F6224B64F25422E" modified="2016-11-02" version="1">MVHADHDEPSFFNDGANHIQQQVHQLYRTSSPTRALVFRYLDEHPDAHQEYLELLRPFGPMGSLNPSFGAEVASESDFYLSATAEGYFLQPDDGLQEDLWQLVTGVEEAADELEFEYPSDLEGFGVDDATDDEVPPQAGPEVLLDTINTNSIDSDDVDPHVNSDSEDNANGATIVSNNTVIIDSSDADPVANNDNGLNTDDTTTIDNTAANTVSNDAPVDASSADTNMVPYPAPAHLVAASRSQPAARAWALWEEDACIRHVLDIHHEGQIQGEARFAEALRRMQLVDGCKRTGGGAVKNFWNRKGRLRSRFDERRNKRAPLATSQQGRKVARTTTTSKQRKDTPSAHVTKSRSTTTRCQKTPEYSSEEDEDEESDFIVESDNDEPEHIRQSRKRKDRDDDSEDDYQPSPTLINSVAKGLRTSKRVRSVAQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKJ6</accession>
    <name>A0A1C1CKJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lactose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LAC12</name>
        <name evidence="10" type="ORF">CLCR_04775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04775"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02894"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF13">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="64"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT49017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="548" mass="59820" checksum="18AB6BEC5D32B2C3" modified="2016-11-02" version="1">MSALAAEKAAQFSQVSHAGHIDDVSVSQEVEMLRTLRGVAAVEVAARLEPPVRTSKRMLQLYFICGFMFLGSTMNGYDGALMGSLLALPSFQDQFGATILGIKTGIISSMLQIGSVSALPSVGPCADLFGRRVGIAVGCGFVVMGTIFQGTSHHVNQYMAGRFFIGFGSTIANAICPSYVVEFAHPTMRGVITGLYNTCYYLGAILAAAVLRGCVHYASDKAWLIPTWLQMGFPAILLLGCLFFPESPRWQYSHGKFDACKASLTKYHGNDDPDSLWVKLQMREFEEELELDGADKRWWDYRSLFNSRASLYRVLLCAVAISAFSQWTGQAGVSYFLPGMLSTSGITDTTTILDINLGTTLSSGIAAVSGASLMDRFGRRKVLIPCCATLTGIWAIMAACTGVYYQDNNAAAAKASVAFIFLIGMVFSFAYTPLQALYPVETLSYEQRAKGMALQNIAGNAAGLVNMFAIPVALQQITWKTYFVFMATCGLEAVYYWFLMVETKGHTLEEMNAIFRARNPVQVSLVRKDEVEQATTKVKEVVELKEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKP8</accession>
    <name>A0A1C1CKP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxypropionyl-coenzyme A dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKP8"/>
    <dbReference type="STRING" id="86049.A0A1C1CKP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11319"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02909"/>
    <dbReference type="eggNOG" id="KOG0016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF4">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="316" mass="34683" checksum="B3D5CFF14E173ABE" modified="2016-11-02" version="1">MLPDPVTVQIPRSYEALPVKDIKVSHYPEGAAEATAVVVVTLNRPKQGNAFTVQMMRDFELVYPMFDLDERVKCIVITGAGKFFCAGADLDIGFPSGGDRERLVDHRDSGGRLNLCIYRCRKPTIVALNGSAVGLGMTLGLSAAIRIAHASSKYGFVFARRGITMESNSSFFLPRLIGHSNALYLLTTGDTYRGDSKHFGSLFQEVLEDQAGVLKRALELATTIAEKTSVLAGFMNRELMWRGRPTAEETHLLDSAVLYHMFANPDCKEGVQSFLEKRSAKFSATLEHDGPPLYPWFAEVDTGSRPRAKASGTAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKV1</accession>
    <name>A0A1C1CKV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ferric reductase-like transmembrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_04640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKV1"/>
    <dbReference type="STRING" id="86049.A0A1C1CKV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04640"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02808"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF28">
        <property type="entry name" value="FRP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="361"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="648"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT49117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="723" mass="81027" checksum="9B1407F85336225B" modified="2016-11-02" version="1">MSCLTPLCVEAAKQMDGTVLPDEFLHTLRLSLKPSSNLVDTLANTGGEPQSDFIRKLIAAVLWHRKFVLTYYIWIAAVVVISCGFETYKRRRHRSDGTRSSNVDVSKDSAIDPTASSSSSSTLTGANTPPQKDVDEATPLLLQKETKERPHLRNRLASFLLYQPRPVPALTSPINTLPDNGTSLSILFFLALNLFYLFFRSPLSPQWIFILVDRAGLLFVVNLPVLYILAAKNNQPIKFLTGWSYEGLNIFHRRLGEWMTCFAVIHMFGMFLVWYTILQPMGFTLLHYLTTKVVFLGICAIVSYFIIYITSIGWFRRLYYEAFLGLHIFFQLAALVFLFFHYPTAPPYVGAALAIWVVDRGIWRIATSSRKFIATLAVAPDGQTILLHAEIPLRQQKSASRIVRNLHYGWAPGQHVFLTIPSMGFKYRFQAHPFTIASPAPPANSVSRHLKSWPLQLTIRAIEGFSLDLLQYAKFHQHCEIVLDGPYGSVSALEAAHAADRVCFVAGGSGIAVTYPLAWDVRVSDDAKTDAIVATRTVYEDGRRKSPPATLECNQPNQKSKYMHFWVRQDERHKEWITMVPKANATIQDPAHTGFRYPDQAAQASRVEEVSSLITRAFDTRAPPPEGGRPDMKTEIWTWVTSIQAGVSSRSPSSTTVEDTASDPSFDLSPNTKTSMGPAPSRDDKICIIVSGPDGLVRDVRNITAELVKQGWDIDVHVEKFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKY7</accession>
    <name>A0A1C1CKY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKY7"/>
    <dbReference type="STRING" id="86049.A0A1C1CKY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04799"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02777"/>
    <dbReference type="OrthoDB" id="4160884at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="530" mass="56513" checksum="E42C7CD91DBD8983" modified="2016-11-02" version="1">MPSLARKSMKFMRDVYNIAANPDGSSVPALPAHSQGFQPSQGLSGQFTQTYGHQNPPLPAHPTYPANSSYGYPYVGPQQSQPQPQPYGSWNVPPTPVSPLSPQLEHSFPPTTTSSPNNMSAFGVPLSPQACLSPSTPQLCHQQPQFAAPPPPPLPQRPSHHGHSPSWQGSSEFGWQSQSHSDTPAMSHSVHEYNQAPQYPIQPFSNVQHPGPGSYHGQADAQSTRPSPPPLPPRMQAQQPDLVPNQAARVPNSPNRPYPSQESYVSTPNVPSPAQFNLPECHEMAADSIPAQPPIRQHQHVDISSLAELPAADQGRITPPPPSLDTHPATMGSTAVGAVELPASPIRRSSHHTTHQRHTSRPHSQGHNPPSAKELDSTPAPTSAPFALMHRDLGVALPPSTVRSPAYLSLSQSQHSDTDTTMPLSTPPPPPPPSLQTPPSTSSCPEEPPYDEPPARVHLRPAGSVQEPSRSGSRSGSCSGSCAAGRPGRRISAAAATLPYPEENGPVVMPLHFDFTNADRQGGAMVEGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLK0</accession>
    <name>A0A1C1CLK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">C2H2 finger domain protein FlbC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_04966</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLK0"/>
    <dbReference type="STRING" id="86049.A0A1C1CLK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04966"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02610"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000793">
        <property type="entry name" value="C2H2 finger domain protein FlbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001278">
        <property type="entry name" value="C2H2 finger domain protein FlbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT49331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="354" mass="38421" checksum="B55CD964A011535D" modified="2016-11-02" version="1">MTMVIDNQGRHYGGLSYDHMYSNMHPSPQFSDPWSHQTGTTSSSSFPALSKTDSSRSGISMPYSHMPPVTGSMAQGSAYSGTVFSSSDMLSYPQDIPRSTYAEQSYSSPAATSSSYAPSYSSLSYAQSLHQQQQQQQQQQHRKLSDAVDNSRAANASFGELDASRGMLALSHQTMQDLTPRNIYEVRTQRASADSYGFPQAASSHSSISNESGRGYPYYAPSSVGSVSDSATDYSSAASDAGYESMAASRTLPRPAQLLGAPLGPPAPQSMMSQFSSKMSANTQKKHKCKICDKRFTRPSSLQTHMYSHTGEKPFACDVEGCGRHFSVVSNLRRHKKVHKGDSQSTASHSDVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLS0</accession>
    <name>A0A1C1CLS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLS0"/>
    <dbReference type="STRING" id="86049.A0A1C1CLS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04900"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03317"/>
    <dbReference type="OrthoDB" id="4708870at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="439" mass="50572" checksum="3960DBAFB47E91E6" modified="2016-11-02" version="1">MASQSSKRSYPMFDPIPAGVHRHISYHLQAKLLDGFRSVSSTLEKFKEARYTDVTILLAEPSSSDTPLDSHIRDLLGLPLLNLQYESQGNAAIHSFLYPWPQLSEIDFYIFHTENGIVEETDTGVMTDGSFPRYVNVILKVWKSTCDLDNFRTAKIDQGLRAMLGKIISPHGLTYKPDGLYLRIQDVELADKRLSCVKVATNKEDIVQYLGLKKRRIETFRTWEDLMDYAMTCRFYNPAAFRVEVNGRFSGSNDSENESPDRHSLNMIKYFIKIYLPANAGVVGGEDACLSRKQVRCDVKDYFGPDFAQRFERSKTKAVFTVDCARLFSKTRNELPKYVKGTDLTYAVKGLKRVVGLYESKYKDAMLDAPEIKGWADMREAFEQRRYRAFRDEAKKHWIYVGAYQKWLDAKRSAQHYKAYKMRQEAQLQERGKPHAKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM16</accession>
    <name>A0A1C1CM16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NIMA interactive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_06853</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM16"/>
    <dbReference type="STRING" id="86049.A0A1C1CM16"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06853"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09805"/>
    <dbReference type="eggNOG" id="ENOG502RZ1J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="312015at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021622">
        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
        <property type="entry name" value="ADIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="87"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="488"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT49544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="69473" checksum="E050F8F81162D523" modified="2016-11-02" version="1">MESHSLERASQYLNNILLARGLLTNGKPIDFARPDRHGSNTDATMSRVINLVHDLVLRRDQDAEQREILTTHIRQARAADSQRAIDLQRLQDKNTELARAAAAAESQERVLKAHMRQADAQAKELKEQMLRMKSTLDQVRAKCLSDVRKRDAELDKLKAHLAGMQRGKKESSGMKINTINWEPETGGRERRNGQAVHRSEWSLEQESNDFLAALVNEMSGENVSLRRIITDTAEVLRELTGLEGPQPGAEEPEQDTEEDGIGIPGQYRKSRQKAARAQQQAQAQAQAEAEAQDLTSCNELEQQMAGILEHCRAILKDPSFVPIEEVQIRDEEISKLRVGWEKMASRWKEAVTMMDTWRKRVDENGQEFSKEDLSRLEFGKSIALLPNGQPVFGQDEELSSIFHENSRLEEESDEEDLDQQLPADERGGVQYPRLPDNDKTGIQSHHRDPDIPPTEGRSPKRRASLARKAGLNLGKPIRPLQPVGLSGLNKSPSHGLALSSTNSTSKQGAQSGLGSSDSAIEMDGDRPDEDDDDDDVWLDENLTKPRISRKMKQREPPLSVSEKLAAVEAEALQAQRQPSSAHVEPGRKRKHANANGVKTRKASRRRSTLSPEELAELMGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM47</accession>
    <name>A0A1C1CM47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM47"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06909"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09864"/>
    <dbReference type="eggNOG" id="ENOG502QS2E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="228"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="578" mass="63881" checksum="F0BC4B7A9DE90D1B" modified="2016-11-02" version="1">MSGSRPDQGLESHHTVLNNDDRQYNVDLKAANLDSSLMAMPAAINDVSASEPSQAGIRESFPEESWTHSHDPGAGDASPEVSLSRGYMGESGFMQIFRQGQTTTYLPTSSIIPGLRAETLSMSPLLLQAFEETHHEYCYPFCPILDKLNHSGDDPFAGSVLLQQALAVLGTRVNPPVIQHDHPSLYYRRAKTLFYMSHEPNPLIRIIAIIFLQWWSAGPPNVVSLDSQYFWTGVAIRLAHEIGLYREPTRNHSLKLGETVGLRRRIFWALFGRPCLIHLEDCDIQQPTLTDFPADQAAQGEIFIHYVRLSEIIGRLSRRLSLGSDRSAPALDIIFELQNWVQSLPQHLLLPFGAARTATRDFRRDVHQLHLPYLTAIMLLYMNSSSHALPKASATALLAASCVARIFQDFLARGSINFVSGIGGWYMTVAILALLHGSQIPALRDCANEQIDVLMIALREIAKSWYSAEMFLRALEKHVKGQSEEARGNPSADTLQGDPGTTSSTWSDLASSDGVDLLGFFPGHTAQTSKLFGVFYADEAADVLMNLAWPADFNTSVMDLFDQTVEGMTGTFGFPAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMP8</accession>
    <name>A0A1C1CMP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 1-aminocyclopropane-1-carboxylate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMP8"/>
    <dbReference type="STRING" id="86049.A0A1C1CMP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07331"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09956"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="185"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="351" mass="39618" checksum="16D21FEE24EF2316" modified="2016-11-02" version="1">MVLTTSHHQYPPFAEGVTTAPLVSISLSKLEADDAAESRTFFKASRELGFFYLSMEGSALGEKLVSQAEQLHVIQKEFHSLPDAEKDKVAREKIDPFFGYRHLGTTEMEDGSVQRNENYNMRKDDLVGNCKPLPCPDLIKRNWGLLASYARNCRAAIDIMFTHLERNLELPIGTLAKLHRIEERSGDHIRFNKTAPGKFSEEKARLGEHTDFGSLTILFNWLGGLQIRLPQTNEWVYVRPVPGSAVVNLGDALVRFTAGLLRSNVHRVVPPLPPQDKIDRHSLVFFSRPEDSVVLRRLKGGLIDQQPESQKEELELTSEEWILRRSVGDLKGVYTHQGGLELRLPMVQGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CN90</accession>
    <name>A0A1C1CN90_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_06941</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CN90"/>
    <dbReference type="STRING" id="86049.A0A1C1CN90"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06941"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08886"/>
    <dbReference type="eggNOG" id="ENOG502SNUJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5424793at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT49976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="59626" checksum="428A702F586FA7B3" modified="2016-11-02" version="1">MPTWQPCERSGVTCVYHEAIKKTATLKRIKGRFAPNNAAVGEPRLLEQVRTTSAGQGDEAAFGHGLLVELGVGASDQWPACRDLELQQAKTFFDQYTRMAQAVPFAIQLASTHSNGKDAATDTHALLSRLLETNPVLLVAAILTGSSSDREFEKQADNLFRHVLADRVIVRGQTSPELLQALLTYLAWYHRRFELETHQVYQFLQLANGMVADSGFPKKFSKANIPSPQQEADSNEIRAFLLCYYLNCGGGVLGYDRAENMRCIDSLRNAAMILATVSQRPQDKEAPALVELLHLVVRHHTARVSSNCAAKPLEPGPGLLKDWQTTFLHPQTSSTVRSTFHFTTAYSLLKSSKAKSPSPADVQVCVYHFQQLLSNIVDQELSYLVRMGIVEWAHLITTLFLLARLGSLTATGGPPTDSARPWPVNEYIERFRSLHNSLTQAEPEADIALRAPHLLSWLDRILVAVAERARSFKAHQDESSTDIGHRGSAYELVNSFLENDKSASTRALQTPGRSNAEPRLGGEDFWSEFMSDWLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNG4</accession>
    <name>A0A1C1CNG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07538"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08948"/>
    <dbReference type="OrthoDB" id="10426421at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="240" mass="26053" checksum="FC0010C5A16C6EE8" modified="2016-11-02" version="1">MSQAVRSSPDPTNLPSDLETVPHSSSTVAAMAAPTIAHHAFPLHHTLAWPLQVYSVDTVERERYVTPTQTTPETEAHHFPVLTKPFDTSMGMTGEGVTPTAQEDVVSNFLPHLEQSLTIPPTPAGDMPGHPILALGDGPQQNGQEPRFSAARAIIARTRSSGGSKLEQWYTSPTVTDPFHLIRLDPLNITWQVRREINSKPDHHVDDGTGSADQSSVQEDTQSGHAGDDVETQPTSKMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNZ3</accession>
    <name>A0A1C1CNZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_06949</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06949"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05789"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT50193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="496" mass="54218" checksum="4E10CE1B21BD2D51" modified="2016-11-02" version="1">MADVEKNPETNVIAGAAVAGSAENVPPEGLDGWIYRRRKVGAWTLTYYASPLSQILLLSFCLFLLPGMSNALSGLGGGGQLDPTVANNATVATYCSFAFFAFFSGSIINMIGSRWGLASAGIGYTTSVLSYICYNHTGNSGFVIFAGALAGFTAALLWTAQGAILLAYPHESQKGKYISLNWAIFNMGAVIGALIPLGQTIHGSGSSVGDGTYAAFAVLMFAGGIVGLCILPAKKVVRPDGSRVILMKHPSWKTEFLGLWELLRTDYFVVLLFPMFLSSNWFYTYQFNDFNLAIFNARTRSLNNVVYWAMQIVASFVFGFALDWTRFSRPVRARVCWVALLLLTLAIWGGALKHQSHWSRSDVKPTADARMDWSSPGYGGLFVLYIFWGFYDAAWQTSIYWYMGSLSNSARKLAMYVGFYKSIQSAGSAIVYRLDTLAVSYNAMFGIAWGLLLGGLVFAFPLIWFKITPETSLEADLEFADEVAADVEPAFATEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPK9</accession>
    <name>A0A1C1CPK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ras-related protein RSR1</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">rap1b</name>
        <name evidence="15" type="ORF">CLCR_07497</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPK9"/>
    <dbReference type="STRING" id="86049.A0A1C1CPK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07497"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05578"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007120">
        <property type="term" value="P:axial cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007121">
        <property type="term" value="P:bipolar cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000755">
        <property type="term" value="P:cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045184">
        <property type="term" value="P:establishment of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032507">
        <property type="term" value="P:maintenance of protein location in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000114">
        <property type="term" value="P:regulation of establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04177">
        <property type="entry name" value="RSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000631">
        <property type="entry name" value="Ras small monomeric GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041841">
        <property type="entry name" value="Rsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT50425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="236" mass="27665" checksum="6CA7C7F6435D312E" modified="2016-11-02" version="1">MFLNPTSRPATQWFRPLKKVRWLMEFRGHRREYHIVVLGAGGVGKSCLTAQFVQNVWIESYDPTIEDSYRKQVNVDGRQVMLEILDTAGTEQFTAMRELYMKQGQGFLLVFSICNMNSFYELAELREQIIRIKDDEDIPLVVVGNKSDMEDDRVVPRAKAFQLAQSWGQKPYYETSARRRTNVDEVFLNLCAQIIDKEGARTAFAESQAAQRRRDRPNRHDRRGRRQRNRDRCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPQ9</accession>
    <name>A0A1C1CPQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UbiE/COQ5 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPQ9"/>
    <dbReference type="STRING" id="86049.A0A1C1CPQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07458"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05552"/>
    <dbReference type="eggNOG" id="ENOG502SAHW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF89">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="52"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="297" mass="32899" checksum="0B27B50AE5867A6E" modified="2016-11-02" version="1">MPAVQPPNAFITETLAQYTPRAATYDVSNGGWHVELGRDHVTWLPPPKGGAVLDLACGTGLVALPYAEAVGPDGTVVGVDVTEAMLSEAKRKPLADGSGEVHWVLGDIMDVSSLDAVQEVIRARGGFDIISCCSAFVLLENPAKALDDWVALLKPGTGRLILDVPTEDRTLQYLLNYPLRKALGKAMTYDFDWIEDIHTVEKMFEEANLDIVKSFRTRSYTSERWYDAGQAAEVLEQKTRESGLWKGVIEDWKSEDGPAGADKIKELWAQIWKENLNEKGKLWDGHALYVTVGRRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ98</accession>
    <name>A0A1C1CQ98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucan synthesis regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ98"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ98"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07044"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05372"/>
    <dbReference type="eggNOG" id="ENOG502QTAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097708">
        <property type="term" value="C:intracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="2">
        <location>
            <begin position="133"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="528" mass="57960" checksum="A199FA3D02BF4D9B" modified="2016-11-02" version="1">MTSNDRHASHDSPYRTGQHVPVGQSRHAALTSVATSAIDSQQDLSQTYQDTKRPSVSSSQVGQSPNRPYSPGMRSLNSPKHAGIDEVVSPGEIQMQNFADGSPPPPPVAHSWKKIDRWAEKNYTELWDQLGEGCTQNDINELEHELNMSLPQDVRDSLAIHDGQERGGRPTGIIFGCMLLDCEEIVQEWKNWQIVNEEYLSGGRRPSYSSKGLGNSASSSNHAQNRFWRQELLDRQESQPPNAIQKAYAHPSWIALARDWGGNNIAVDLAPGPMGQWGQVILFGRDYDCKYVVARSWAHFLATVADDLSTEKVFVDEDTGELKLREFRTEAVEPAYMDILRWRADQKYGRRGPRRRSQPGGINSNTVAQNGRHSPYGSPVLGEDRGRSPQRFSRGPAGSPRHAVGSPLARVQEEIAQPQAIRPGGDVVRDFAEAAEQSVTEGKKRAGPAPIDPKAAPSSKDDTDKLVDVPTPASLKGADLKDFPSTRLTRVLTAGNNESTDDAPTEPEPEVKGLGVNGIEGEMKTVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQC3</accession>
    <name>A0A1C1CQC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQC3"/>
    <dbReference type="STRING" id="86049.A0A1C1CQC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06583"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05328"/>
    <dbReference type="eggNOG" id="KOG4347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000021">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000015">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="284"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1166" mass="128797" checksum="5C7E67E343D46F4F" modified="2016-11-02" version="1">MLSSFVQKFIEQSPLSTNSDNRPSKAALFREQFRLPAGQNPLHEITAELFLPLPSSAAGGPITSGEKSSDNGNKYVGELHLSEHFLCFSTIRTSFLPTASHASSTSFTGPTQGAGPGGHGFTLPLCSIRRVERLNTHHDKFSLALTTFESVPKSATGKTKAPSPPARKLILTLDGSRNACERFCDGLKKGLREGMKEVDSLRLVVSQCYSEYLLDPSRLKAKEEGTTPPEPPDTGLGMLFRYPGDARKLRDRSKIRLWGEYLRENGRNATIVRQPTFHKLIRVGLPNRLRGEIWEISSGSFYTRLRNPNLYAKTLAKFTGKESLAIDEIEKDLNRSLPEYPGFQSEDGIGRLRRVLTAYSWTNEEVGYCQAMNIVVAALLIYMSEVQAFFILGALCDRLLPGYYSKDMYGTLLDQRVFENLVERTMPILWEHLVKSDVNLSVVSLPWFLSLYINSMPLVFAFRVLDVFFLEGPKVLFQIGLAILRINGEELLDVSDDGSFISILKNYFSRLDESAHPHSENEKLRAITRFQELMVTAFKEFAGVTHASVQELREKHIDGVKEGLATFAKRTSIRNLGPESKKLSAEDLSAIYDRFFSVLADRQGRAKAREEERRKLQDQRTRPGLWTQHSSRNNDEPARNAPPLQTMDYDAFREFLANTAKWAVTDSPSSPGRDITSPNQNQRNRSKTLSQWGSGPEPADHDFMQRLYGKWDESQQGEMTLQQLVRGLARFKGTTDIMNSMSLFFDLFDDEGTGKVDREGILRMSESLLFLSRRGFDGAITPTESAHTMTSPLSATEQQNGLKMSTNEKFLGSVSAFIRRCFEYADPDDEVDAGASKPESADVHHPAEEADLLDLTETKSDTKTIASPRATEKDPLSETTPPHTPSLSIVHDNRRSSSARAASHNLALDPNKPLHITLPTFRMVILADELLEQFFETFFPQSFRLADTAPDASSLSLASSSNTLSGNLTTFTNLGTPVKNLLNGAATNKTLPDVGRAGGVVEPGSRGLRGVLDNIVNDGMRMAAEMRKRMDDAQREFERNAREQGQKAYRDEEDEDEDYDEKDVGIGRRDQELLEGAEVASIRTATGLSGDGTSTRSRAESSASRESATGGGGGVSGSGSGSGNGNGSGNRPGTLSRMTSSSGAKSVSILDVDVDDLSLTSNSIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQK3</accession>
    <name>A0A1C1CQK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_11345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11345"/>
    <dbReference type="OrthoDB" id="4779287at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650969" evidence="2">
        <location>
            <begin position="20"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="229" mass="23154" checksum="0C24F0C29250A2A2" modified="2016-11-02" version="1">MLALGASLAATFLAGLATGTGVGAPLLKRSNQPGIAGNAAWDGSTYRCPEGSNIFLEKWCCPEGYEYDTNSGQFTSFICCPIGGPECSQQVLDCPICADSNWVYFDIGGTNVPPTLPFCCEQGYAPAGLPEPQPANVCTSGANLWTDYATASQCGQVADATGSPSPGTTSATATDSGGQSASATSAETTATADATTGGSSESGADSSLSFSAHLLLMTMLLPGILMVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQQ2</accession>
    <name>A0A1C1CQQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07698"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="130" mass="14051" checksum="9C2F56F1704DD0AB" modified="2016-11-02" version="1">MEGQGSLYQPRPFMWKSRGFVGEVGEDAGPPPGKGPESFLPFGQRLPSRRSAPLCNPFGSAPRVAAAVSRQSHVFPTEDSRVAEKASQADDRRRLNDLACQDGTSVSVKLQEGGYQLPAICSNISHHDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQQ4</accession>
    <name>A0A1C1CQQ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQQ4"/>
    <dbReference type="STRING" id="86049.A0A1C1CQQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08705"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09486"/>
    <dbReference type="eggNOG" id="ENOG502S2HJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF203">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650985" description="CMP/dCMP-type deaminase domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="292" mass="31582" checksum="11615CE5CEBA70D1" modified="2016-11-02" version="1">MLLTLMPIKGASFTFLLLIVLSSYFHAKAHSQDPNHHLNNRDDLSHWPDPETPYTLPPDPIPLSTREHWMRRAVEALSDLNDGSPCPFAAFGCVIVNHSAVATGRGGIADVELGVELGSEVCIGANAIVREGNPTMHGEVAAINNCTAILTDPAGKYKLTGPEALKALGDLSLYTTAEACPMCTSAILYGGFKEYIFSTSIPTLRSHNWPQIVIRSTEIFARSVGRLSAHRTRIVGEVWANETEELFRWQFGGAQAACPRGCVWEADGEGAHGGCVKGNVEEAGVYAHKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR12</accession>
    <name>A0A1C1CR12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DnaJ homolog 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_08354</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR12"/>
    <dbReference type="STRING" id="86049.A0A1C1CR12"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08354"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09565"/>
    <dbReference type="eggNOG" id="KOG0715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256793at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000053">
        <property type="entry name" value="Putative Mitochondrial DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="82"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="13">
        <location>
            <begin position="233"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="10">
        <location>
            <begin position="233"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="477"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="517"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT50922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="548" mass="58488" checksum="B8491AD471A9EF0D" modified="2016-11-02" version="1">MSAIATPTALGGTAPLRSLLRTTSQCPRQRNTFTRKAQTRRFYDAAAPKRPVPQRSPSASPRCPSHHRRPFSATPAFQATKDPYATLGVGKNATASEIKKAYYALAKKYHPDTNKDPNAKEKFTDAQSAYELLNDPQKKAAYDQFGAAAFDQGAGFDPSAGGGHPFAGAGGGNPFSGFGGGFGAEFNFEDLFGAFTGGGRRGRRGGGPFQEEILVGENIEVQTNISFMDAAKGVSKNITITPLVQCGTCKGDGMKQGSSRQTCKRCNGTGTRVHVMQAGFQMASTCDTCNGTGTVVPRGSECNTCSGNGVVRKRETVEVEIPGGVEDGMRLRVAGSGDYPPTGLSANPKIRTQRGDLYVFIRVAPDARFSRNGADILYTASIPLTTALLGGEVMVPTLDGEVRVKVATGTSTNDRITLGGMGMKRLGGRGAGSSGDLRVEFKVQMPKYLTANQRTIIEMLADEMGDKTAKRIMNVGQYKNQDKQAPTTDSPASKPSDKKADHKNEGFLKSAWHKLTHQHDNLETDKPGKESKAEQHEDDEPKKASGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR14</accession>
    <name>A0A1C1CR14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Eukaryotic initiation factor 4A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Translation initiation factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">tif1</name>
        <name evidence="21" type="ORF">CLCR_08544</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR14"/>
    <dbReference type="STRING" id="86049.A0A1C1CR14"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08544"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09592"/>
    <dbReference type="eggNOG" id="KOG0327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 17 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="54"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="235"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OCT50950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="396" mass="44715" checksum="640E24B58706AC2B" modified="2016-11-02" version="1">MADKGLEEINENQIESNYDEVVDSFDNMNLKPELLRGVYAYGFERPSAIQQRAIMPVIKGSDVIAQAQSGTGKTATFSISALQKIDPNLKACQALILAPTRELAQQIQKVVVAIGDFMNVECHACIGGTNVRDDMKALQDGPQVVVGTPGRVQDMIQRRVLKTDNMKMFILDEADEMLSRGFTEQIYDIFQLLPQSTQVVLLSATMPQDVLEVTTKFMRDPVRILVKKAELTLEGIKQFYIAVEKEEWKLDTLSDLYETVTITQAVIFCNTRRKVDWLTDKLQARDFTVSAMHGDMEQAQRDVIMKEFRSGSSRVLIATDLLARGIDVQQVSLVINYDLPANRENYIHRIGRGGRFGRKGVAINFVTADDVRMMREIEQFYSTQIEEMPMNVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR70</accession>
    <name>A0A1C1CR70_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ribose 5-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR70"/>
    <dbReference type="STRING" id="86049.A0A1C1CR70"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09207"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09618"/>
    <dbReference type="eggNOG" id="ENOG502S47V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2106730at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="166" mass="17702" checksum="936D99A00E7A4E2A" modified="2016-11-02" version="1">MTSTTTNGTKAPLRIVVGSDNAGHAYKTALKDVLHKHTGVTQVLDVGVVDADDATAYPHLAVDACKKIKSGEADRALLICGTGLGVAISANKVEGIRAVTAHDPYSVERAVLSNNAQVLCFGQRVIGLELAKKLVDEWVELRFDETSASAEKVAHISKYEEQFGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR86</accession>
    <name>A0A1C1CR86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dual specificity phosphatase ibp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ibp1</name>
        <name evidence="3" type="ORF">CLCR_09196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR86"/>
    <dbReference type="STRING" id="86049.A0A1C1CR86"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09196"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09648"/>
    <dbReference type="eggNOG" id="KOG3772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="102559at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="34"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="174" mass="18780" checksum="04CB6BEFC1C86EC8" modified="2016-11-02" version="1">MTGRASSNANSITLSSLNYVPPSAVAQLLLEPAEKAKIAIIDVRDSDHIGGNINGSQWVPLNQLDVKMPELIRTLKDKEKVIFHCMLSQQRGPKAALAYARAKQAAQHKEANEAAEAEAEAAAAAEEAKDHGTGETKQSLKQEVCVLDGGFGAWQATFGEDPRLTADYQPDIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR92</accession>
    <name>A0A1C1CR92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Noorani M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR92"/>
    <dbReference type="STRING" id="86049.A0A1C1CR92"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08237"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09642"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="633" mass="72299" checksum="7772D42486F6A87F" modified="2016-11-02" version="1">MRLIDVKTLQLKEFGSGEVPRYAILSHRWESEEVSFQDMSQPKTFGKRGFAKIQSACWQARNKGYSYLWVDTCCIDKTSSAELTEAINSMYKWYQNAEICFAYLTDIESRKHAIKDSMWLTRGWTLQELIAPKHVSFHDRHWVFLGTKSDLAHELSMHTGIPIEVLVGHSRPSSCSVAQRMSWAARRQTTRIEDRAYSLLGIFDVSMPMLYGEGEKSFARLQQEILRLSDDQSIFAWDRGHEGYFGGHSGLLATSPSQFVTCQSVVRSSHGLPNTGRFELTNVGLSISLLTVPWAMETYLCILHCTLRASPDLRLGVFLERLSSSQDAEQFARVSLNGNTVLCVPLQTILQDPQHRVRHIHVRPAIIDAPLRRWYGFRLHEFTLPEYTVEELYKTAFHFRDSLRVITRYSHEEMRAAKLYHPNGLAGLPPRPLFFGMPRGRSDAMEPIRGTAAIFYIPPSRKDKKGERVCWMKFGFDKNFSPVCILGRRKSLWGGNPAHLAADEDSYYDAEEQPGKHALLFRSDWLTQLAPCDEDRDIAGLWRMRDYCVIRGHRDLGLDRKIQFLRLHISVKLEHIPPNYPVEGRPSSLLPGMNVWTINVRTWGPGGKDGGMKTAQTTGELLLRGIDDIFMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRT8</accession>
    <name>A0A1C1CRT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_09000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRT8"/>
    <dbReference type="STRING" id="86049.A0A1C1CRT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09000"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06885"/>
    <dbReference type="eggNOG" id="KOG0407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT51188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="194" mass="20622" checksum="2FE2FEA09C88ECA3" modified="2016-11-02" version="1">MAPKKKIERAATENVSLGPQVREGELVFGVARIFASFNDTFVHVTDLSGRETICRVTGGMKVKADRDESSPYAAMLAAQDVAQRCKELGITALHIKIRATGGNGTKTPGPGAQSALRALARSGMKIGRIEDVTPTPSDSTRRKGGRRGRRLTSNPVEAGMIEIEHKYAKNGSSAWSSAGGFLATNGTHGEVRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRV0</accession>
    <name>A0A1C1CRV0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRV0"/>
    <dbReference type="STRING" id="86049.A0A1C1CRV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08499"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06850"/>
    <dbReference type="eggNOG" id="KOG3184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="6">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="94"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="253" mass="29389" checksum="17F8F6468DA7CDD5" modified="2016-11-02" version="1">MTKPTVKSTVPTKDQVLVPETLLKKRKSQEKAREQRAADLEKRKKANKEKRGVIFKRAETYVKEYRDAEREKIRLARLSRQEGNFFVDEQPKLVFVIRIKGINKIAPKPRKILQLLRLLQINSGVFIRLTKATQEMLTIVNPYIAYGYPNLKTIRELIYKRGYGKINKQRIALTDNQLVEDNLGKYGIVCVEDLIHEIFTVGPNFKQASNFLWPFKLSNPNGGFHARKFKHYIEGGDYGNREDAINALVRQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSD0</accession>
    <name>A0A1C1CSD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">taf2</name>
        <name evidence="11" type="ORF">CLCR_07908</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSD0"/>
    <dbReference type="STRING" id="86049.A0A1C1CSD0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07908"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06673"/>
    <dbReference type="eggNOG" id="KOG1932">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 Ig-like" evidence="9">
        <location>
            <begin position="572"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 TPR repeats" evidence="10">
        <location>
            <begin position="755"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1179"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1220"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1182"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1231"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1241"/>
            <end position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT51409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1288" mass="144779" checksum="696B1D011CDDCBA0" modified="2016-11-02" version="1">MESREEQPPVIREPTFTVAHQKVELEINFNQEVTGRTEITVYPNSADLKEIALHGRQCTINKVLVNGIPPSSVQHDDPCDQLRLHARVSVHQHHLLAEKIAGSIGAEPEPDIIITIPKKVRIVPVEVAEVHTQAAGTIKITDPQTQGASATEVTQALADTTAAQFTPLTVVIEFESCHARDTLQFSAGRRGSGRWPHAYTRTKLGAGGASSLFPCVDKLNSRCTWDVSIKCPRTVGDAIAQAVSSDPAARSQGLVNTDPARQSYESVDMVVICSGELTDEILDKHDPSLKTVFFSCSQQLAPQQIGFAIGPFELVNLSELRDAQQVEDIGRNAVEVLAYCLPGRAEETKNTCLPTTMAMDYVVQKYISCPVKSYTMCFVEDAPAETFVFAGVTVCSTRLLYPEEVIDPAQDVTRTLVHAIVSQWIGVNIISASPLDNWVIIGGAYFITNLFMRELSGNNEYRAYIKHQADTVVELDINRPSIYDMGAMFHVDPSAYDFIALKAPVVLFILDRRIAKREGTSKMPGILGKILTRARTGDLENNALSTELFQKTTERMGHEKIDDFLGQWVKGAGCPRFFARQRFNKKKLVVEMTIQQEQSDRQTTRDLNPESFMREVHEDFHGVWAAEPQQVFTGPMTIRIHEADGTPYEHIVQIKDPSTTFEVPYNTKYKRLKRSKKQRARASTKAAAEQVDEENDALVYCLGDVLQSEEEIAKWRIQEWTQEEEDKMNMESYEWIRLDADFEWICTVNLAMPGYMYVSQLQQDRDVVAHLESIRTISRFPPHATMSSVIVRTLMDRRYFHGVRALAAKALVRHAAEEVSNIGFHHLKKAFEELFCVTDRGSTMTRPNDFSDQLLYMVQCEIVEAIGKVRDGRGHTPKEVRDFLLDKLKFNDNSANDYSDAHYVARLMKALTDAAIARPHYTERDVIGDFDLEDEVHELKQFERQFLEEIDRYRRMDEWTSSYQNLYSRTALECQAMLAAAGIGTFSPLHFLQYTRPGNYDMLRQTAYATLLTPKIFDDPAILRYALYCMVADPSPYIRQSLQQAFGVVLGRRAIGDKSTATRPAAAEGLVIEGASIEEDDASKRQEELARRQNLEAALKALKGELGAHEALQTALWNAICYDQIILEDLQILLDFCRLLYDPVNEMKVTLRLPRYWKVQSLGKGKLKFSETRKVRVKPVPKWHPPTPAVTMPQPPAQARPAIPNLKLKLNLNKNNSVLNRQPSISLSNPSPTPPPPNARPAPARQSSFSTQPGQQVQTPVVELQRRITLKIPTLKLNKGPSQGGPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSD6</accession>
    <name>A0A1C1CSD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_08304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08304"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06682"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF78">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="523" mass="58610" checksum="A6A268E71BEFA561" modified="2016-11-02" version="1">MGDNKIRADGVILDHEVLGEKGNLSHEEAMHFGALTEDELAIEKKLVRKIDLRIMPLVVLVYLMNYIDRPGADENARNNYAAARLQGLEEDLNLRGDQYQTGLSILFVSYILAQVPSNLLLNHLGRPSLYLGFFVCAWGLVSALTCLVKNFAGIVVARLMLGFMEAPFFPGVLFYLSKWYTKKELNLRMSIFYSGSLVSGAFGNLIAAGILSGLAGEMGLSAWQWLYIIEGAITCFIGIIIIFVLPDFPSTWKRLSPEMKHVANRRLAIEAAEADVDEAGGMSQWKGFKLAMTDSKTYMLAIAYMCITGAAGFQNFFPTLTATLGYNRIISLLLCAPPYIFMVFYSFAHSVVSDRMSNRFWFFMYPIPITIVGCIVFMTTDSFGPRYFSLFLLIFIFAMNGTCYAWIASAIPRPPAKRAAAYAFINSIGNSASIWTPFTYRTQDAPHYVLALCICIALQVVAAIMGVSMRIKLTRQNKRLERMENEDVPLTERDLAKLRRTAEIEGIDLAAARRLQKGYRYMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSH2</accession>
    <name>A0A1C1CSH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSH2"/>
    <dbReference type="STRING" id="86049.A0A1C1CSH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08874"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06647"/>
    <dbReference type="eggNOG" id="ENOG502S0WG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5358398at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048273">
        <property type="entry name" value="Luciferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase" evidence="1">
        <location>
            <begin position="170"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="268" mass="30158" checksum="3A476C612EE6E71A" modified="2016-11-02" version="1">MDRLKQLPKLPPRELALKAAAVTATLSAIIWCVRDYHEFLALGRGGAPYNIMGWAIVTLLRPFALSKRGAKQVSSYPADGAHEDIRDLPTRAGLPASVGGIVPHRQLSQHPPEEMKQYITNLFKNAVAGNSEILEERLSLYERHNPALFVHDNILSSADSAVPETARISRGEIGHIHPDFSIHLYLSPPDARLIIEKGWGEKHRLSKPENSLFKFKRFHIADTYILIYGPRDEQEIEVVRKILQSSIRFMTGRSNVELSEWRTALSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSY6</accession>
    <name>A0A1C1CSY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mal1</name>
        <name evidence="6" type="ORF">CLCR_08190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSY6"/>
    <dbReference type="STRING" id="86049.A0A1C1CSY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08190"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06519"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000007">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF232">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 13 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="20"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT51577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="602" mass="69695" checksum="5ADA772B08504DE9" modified="2016-11-02" version="1">MSQKSSYTTPKWWKEAVIYQIYPSSFQDSNSDGWGDVKGITSRVDYLKQLGIDVVWTSPIYKSPQADMGYDIADYKVIDPIYGSIEDVDNLISELKKRDMKLMMDLVVNHTSNMHPWFLESRSSKTNPKRDWYIWKPPKAVSDAGVTEPPNNWAQILGEANSAWTYDTETGEYYLSVFTPDQPDLNWENPDVREAVWDVMRFWLDRGVAGFRMDVINMISKVPTYPDAPVVLDPQTHAYQPGTQFFVNGPKLHDYLREMNRQVLSRYDTVTVGEMPGVSDENEILRTVGANAGELNMIFIFDLVDIDKPNVRMALKPWDVTEMKSIITRWQRCMIERDGWNSVFIENHDNPRSISRYTDDSDEWRDKGAKLLALMQTTLGGTLFVYQGEEIGMRNAPTHWDISEEYKDIETINYWKKCQQIYKDNPEKLEEGRRIIHMKARDHARTPMQWDSSANAGFCNEGVKPWMRVMDDFSHGINAEDQMKQGTGTGHDNDSELSTWQFWQRGIHDRKKHADVFVYGDYQELSPEDPNVLAYIRTSEAGERWLVVLNFSAKDVEWTLPETLAIEFWACSTYTKARPEKPQTGHITLRPWEGVLAKCKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT75</accession>
    <name>A0A1C1CT75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase mtr4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mtr4</name>
        <name evidence="11" type="ORF">CLCR_07966</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT75"/>
    <dbReference type="STRING" id="86049.A0A1C1CT75"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07966"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06395"/>
    <dbReference type="eggNOG" id="KOG0948">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="158"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="394"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="728"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT51703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1010" mass="114719" checksum="5BA04A1D3DD79ABD" modified="2016-11-02" version="1">MDELFDVFDDNGQALPANRPTRTDRKRLKRQANGEVKDEANGEDAHASSTDGPSPSPAGVDQEMTDGHEPDAKRVRTEEEPEPVITDTFETEQSREVAASAGLLGAKEEEKVILSHQVRHQVALPPDYDYVPISEHRPPAEPARTWKFELDPFQQVSIASIERNESVLVSAHTSAGKTVVAEYAIAQCLKNNQRVIYTSPIKALSNQKYREFQADFGDVGLMTGDVTINPTATCLVMTTEILRSMLYRGSEIMREVGWVIFDEIHYLRDKVRGVVWEETIILLPDKVRYVFLSATIPNAMQFAEWITKTHNQPCHVVYTDFRPTPLQHYFFPAGADGIHLVVDEKGVFREENFQKAMSSIADKQGDDPANAMARRKGRGKDKRMNKGGTKGPSDIYKIVRMIMTKNYNPVIVFSFSKRDCEAYAIQMSSMSFNEDSEKAMVSKVFDSALEMLSPEDKNLPQIQHLLPLLRRGIGIHHSGLLPILKETIEILFQEGLIKVLFATETFSIGLNMPAKTVVFTSVRKFDGISQRWITGGEFIQMSGRAGRRGLDERGIVIMMINEQMEPQIAKDIVRGQQDNLDSAFYLGYNMILNLLRVEGISPEFMLERCFHQFQNTASVSGLEKELQQLEAEKSAMVIADESNIRAYYELRKQLDVYAEDMRMVIVHPNYCLPFMQPGRLVEIKDGGHDFGWGAVLNFSRRSQGRSTEKLAPQEEWVLDVALEVADGPTPATKTHQSLPPGIRPPQPGEKSKVEVVPVLLKCVHKISHVRIYPPSDMTVSEEKRKVQQALQEVARRFPDGLAVLDPIENMKITDNSFRELLRKIEIMESRLVANPLHHSPRLEGLYNQYADKMVLTTKIRNLKKQIQDAHAITQLEELKCRKRVLRRLQFINEDEVVQLKARVACEISTGDELMLSELLFNRFFNDLTPEQTAAVMSCFVFEEKVNENPVLPEDMARCLREIQKQARNIAKVSIESKLTMNEEEYVQGFKWHLMPVIYAWATGKSFGDIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTB6</accession>
    <name>A0A1C1CTB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">tim44</name>
        <name evidence="15" type="ORF">CLCR_08422</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTB6"/>
    <dbReference type="STRING" id="86049.A0A1C1CTB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08422"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06362"/>
    <dbReference type="eggNOG" id="KOG2580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="14">
        <location>
            <begin position="349"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="68"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="144"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT51737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="509" mass="57891" checksum="FC91A84030A80DDA" modified="2016-11-02" version="1">MVVPRRAPLHGVRQYVTTTSALATVRQAQHGRTAAYRRLLPSPLVYTSRLPPFSPRLTLSDQQLIRSLTTSRSQSQQQPKADPKEEVRDPPRDEKTEQEASGEKEQKDEKSEKEQKDDKPPPPPPHGDKTPWQVFTETLRSEFKASKEWNESTKQLSGSVQQFTESEAVRRAREASEAATKGTSQVLKSTASAIGSGAAWTWETPVVQGIRKGVNATGRGIEKATRPIRETKAFKDVSEAVDDGSSSRYGGWIEKEERRKREEARRLREAQSPEKKQEQMVEDPNAGTNITVHKDSAWRESWTKFKENSKLMQSLFNMKNSYEESENPIISTARSISDRVAGFFAENETAMVIKKFREMDPSFQMEPFLRDMREYILPEVLDAYVKGDVETLKLWLSAAQFQVYSALMEQYTKAGLKSDGRILDIRHVDILNARLLEPGDIPVFIITCRTQEVHVYRNAKTNELAAGMEDKVQLVTYAIGVTRLPEEVDNPETRGWRMIELQKAARDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTE0</accession>
    <name>A0A1C1CTE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTE0"/>
    <dbReference type="STRING" id="86049.A0A1C1CTE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08292"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03999"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF29">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="220"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="514" mass="57365" checksum="3BC9BBC05CABE58A" modified="2016-11-02" version="1">MFSGAPEGGSQARAVLETGGFFKRYMRTLTIWTLLRMSTGVSSSQTEHLYRSSTHLMALQTQTVCSQGIFHGLPTYPETADFTDLTAIVTGANGITGYSMVKVLAAAPKRWSKIYCLSRKPPPAYFYDELGEGASARVVHVSVDFLSDPATIAASMKAKIPRVDHVFFFSYMQPKQEGDVLSMWSNAQELADLNGENSLSFPARERVIPQADEKRVILSLAAANLTPKRFLLQTGAKHYGFHIGPATCPSFETDPHVQTEPNFYYVQEDMLAEHCRKFGCAWNVVRPSYVIGAVRESALNHLVGMSVYASVQAYRGLPLAFPGDVAAWDREHCQSTGLLNSYMEEWAVLSPHTANEAFNMQDGNPFTYGRLWPYLADWYGTGWTPPSEDESAYKVVESRAEKPPRGYGPRGQTRYTFSLLEWSHDPAVQQAWTELQRQHGLDFDPFASRDTVFGQTDSAVIGGWPLSLSMRKARRMGWLGSVDSYEAAFHALRDMARLKVLVPLARDEWCEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTM5</accession>
    <name>A0A1C1CTM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HLH transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08417</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTM5"/>
    <dbReference type="STRING" id="86049.A0A1C1CTM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08417"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06262"/>
    <dbReference type="eggNOG" id="KOG1318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11387">
        <property type="entry name" value="bHLHzip_USF_MITF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="282"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT51855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="530" mass="57335" checksum="0CD13EA457428E3A" modified="2016-11-02" version="1">MPYIKSEPDDFGNNPNHFRSSSSFGISQGYGNQFTNQHTSAGVDPNDLTNFGSVPYNYGGNNMSSGFSMGNSGYGEDELLDSLGFSNNDGDGMFNDFTTLNQPSNNNKGAGAVQSNSQNQMPNIYSSTPDNAPIQSPFLNGFDYSQFRPMGSLPQHMPSHQGPQHKRPSMTSIRKSSDQRSPLSPRPAGIAGLQIGTPESGHLANGRPIRAPHAKTMSGQYDSTPGSLQSYIDSPLSSPGNGIQHAGISETLGPSHHASLPAKVEHGFSTSNAETAEAKKRRRRASHNAVERRRRDNINERIQDLSHLVPQHRLDDDKVKKQLQSNGPMSPNIGATSMSPPNANNTATSLLVGAAGRRAASSAGNITIGLPIEEKEKGPNKGDILNGAVSWTRDLMWALHQKYQQEDELAQYIQSLGGQWPFQVTDDEKRMRSEVLEAMEKNDPSTFSYTRTDGTGLRVPRHTNLAGERIQNPNNPSLSPQSNFESSPGFHSGGSGTNSGSGGPGQPQYWNSAGHPGISFKEEDEFMELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTX0</accession>
    <name>A0A1C1CTX0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">High-affinity methionine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_07898</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTX0"/>
    <dbReference type="STRING" id="86049.A0A1C1CTX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07898"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06176"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06177"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="569"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT51953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1133" mass="126210" checksum="852BF27C355F734E" modified="2016-11-02" version="1">MVSLYWSKREASPAVSENGQDHGATAFLKEGSLRYAVEKGENSNEPTYQEVSGAPVETRSPLGYHVGSVTIMFLNLSKMVGTGVYSTPASVLKGTGSVGLALIYWFIGFLVAAASLSVYLEFASYFPNRSGSEVVYLEQAFPRPRYFFPVTFAIQTVLLSFSASNAIVLAQYLYRMSGSTPTAWQLKGVAVAGYTLAFLFVAFSTRWSYRVSNAIGAVKLLTLVFVGITGLVVLGGNVDRVPDPRANFRNAFSGFEGTEASAYGVTNALVKIIFSYAGYENAFNVVNEVKNPVRSIRNSGGLSLLVVAILYMLANIAYFSAVPKEELVQSSQVAASLFFQKVFGSAGAARGLNFLIALSAFGNLTAVLLGQSRLIRECGRQGTLPFPNFWVSTRPFGTPLGPYFVKWALTMLMILAPPAGDAFNFVVDLANYPASFFAFLMAVGLYFVRYQRKKLNLPPPSKAYRFRTWHVAVIFTILVNLYLLIMPWYPPTGGATGGDVSFWYATYVVTGLGILLACGAYYILWIYALPRWRGYRIRHERQVLEGGEVTHKLVKIPLQELEAWDREHDAQAPRSTTAQARHPVRNGEPQISRSDDTPSTFDSSSYSARDRRGQQHVLGCVVDTSLLCYFSDVVTWRRAYRSASMKRSPIKSVAVIGAGAAGAVTAAALAAEGHFEHIRVFERRETPGGTWIYDPDPGPAPRIIPGANPPETDPPLPVPNGPFPRTTSPCMQERFDRTPIYDNLTTNVPDIAMCFSDSRFPYGPFVPHWVPRHYIENYFSLHRTDSLLVLNTTVEDLSKIPGTQRWKLTLRRKDSVRHVDVWWEEEFDAVILAHGHYSVPFVPQVDGLEEHIRLFPGRISHSKSFRNALAHHDKKVLVIGNSASGHDVAAALVGSVRGPVYQSRRSRSRWEGDKPAPGIEWKPVVRKYLRTGDIVFDDGSVLSDVDTVIYCTGFKASFPFWNDHANGGPIWNYEQSRLIGSYWHTFFGDFPTLGAVGVPRVLTFRSFEYQAIALARVFAGRNTRSLPPSEEQERWERERCRLVSSEHRKFHDILWDNGETMDWLRGLYDLAGLPTLEDRGRYPPVLGDETRWAIEHLRKYPEPGRESCEDPGEGVDGWTVVQPGAAKDSLQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTY8</accession>
    <name>A0A1C1CTY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GCY1</name>
        <name evidence="13" type="ORF">CLCR_08660</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTY8"/>
    <dbReference type="STRING" id="86049.A0A1C1CTY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08660"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06180"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:aldose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042180">
        <property type="term" value="P:ketone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000018">
        <property type="entry name" value="Glycerol dehydrogenase Gcy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="12">
        <location>
            <begin position="26"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="11">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT51949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="309" mass="34421" checksum="F098B5C79F6BF621" modified="2016-11-02" version="1">MTTSQEGKGTKTVFTLNTGAKMPGVGLGTWQSKPNEVREAVKHALLAGYRHIDTALAYGNEAEVGQGIIDSGVPRDQIWITTKLDNPWHKRVNEGIASSLKDLKTDYVDLYLMHWPSSTVPEDLKKHYEDWNFIDTWREMQKLVGTGKVRNIGVSNFVISNLEKLLNAPSTKIVPAVNQIELHPNMPSPKTLAYCKEKGIHVTAYSCLGSTDSPLAKDQTLQKIADAHGKTPQQVLLQWGLQRGTSVIPKSVTKSRIEANFQLDGWELKPEEMEELSNIKTRFKVCGDSWLPIKVFFNEEGDGGDVPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUY4</accession>
    <name>A0A1C1CUY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUY4"/>
    <dbReference type="STRING" id="86049.A0A1C1CUY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08568"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05848"/>
    <dbReference type="eggNOG" id="ENOG502S8VJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="458" mass="51510" checksum="DFF267F1FF783CFA" modified="2016-11-02" version="1">MAIFALPHEILAGILSFLDPQSIIRFGRTCKTAYASTGPQNQILWKSAFLHVFDDPDEAWSMTPGTPPSTNERGFDFHTELSRRFIALQAVRTRSCGSNDRAEAYIEALLSILDTAKFTPNARDIANGKVPIEDDRYTSLNLQILSNLAEWREGIESLIHDTPSREFSPRPITRSMTLRESERCRTPGASRLHVLYGLTNWERVEHKARGAARRKVYDWTRIGADNDYAPFLRGGSGKVDWSLLEGVATVMRLNFSKCVDQIAAPEGFCYSLPHRTLVDPTTPEDWARATGPWLGTYAFLDYADLWTYNNWEGQAEPRMTLDGEPEDCGDLMRLTLKLDPSISSDPRLQTKLPISTDLPVLYFSGHSRGYNGMRRLIIAVRGFACLVPGSREVRWRFLINYGGQDHWLLEGIQPGGVRSGGIFGIWTHCDHEVNTPSGPFCYFPEELCKSTSVVVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVI6</accession>
    <name>A0A1C1CVI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVI6"/>
    <dbReference type="STRING" id="86049.A0A1C1CVI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10210"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03917"/>
    <dbReference type="eggNOG" id="ENOG502S005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651097" evidence="2">
        <location>
            <begin position="23"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="456" mass="45911" checksum="93F4015F2AF2E691" modified="2016-11-02" version="1">MTVFSKSAAFAITALLALAADAHMIMRTPVPYGKSTLNNSPLDGGGADFPCKQRPGVYDAEGASNVAAIGEPQTLSFIGGATHGGGSCQVALSTDLQPTKQSKWMVIKSIIGGCPDAFPGNLNGDASSTDSATFQYTIPEGIAPGDYTIAWTWFNHIGNREMYMNCGPMTVTAAKKKRYAPAPKVSKRQASFPDIYVANIDNKQCQTPENVDLIFPNPGAYVQTAGSGPYATATCNLGNKANNAEQPTASVPAVSGIATSAAVPTDAPASAPTSAPGFAYGSSGQLPQATGGGNDGKYSAGSPTAGSFATGAVSVPTPAPAPSSSADGLQVIPTSVAAGLAATPAVPVSPSQTLTVPRYTNTSVPQIAPGNVAAPTGTASVSTGSFSGVSSGAAGQLTGPCSNEGDWNCIDGSSFQRCASGSWSATIPLSGMKCTPGETGNNNFAMTPAKAKRFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVM1</accession>
    <name>A0A1C1CVM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09996"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03927"/>
    <dbReference type="eggNOG" id="ENOG502T4YP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4160225at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="562" mass="59751" checksum="81812641F8CC3516" modified="2016-11-02" version="1">MTKLTKSPPPAYPGKSNAPGSLATAVPYESLRQQAQPPVPVTTAVLPSSYNDPLPDTNPFSPNFRPDPISNSAEATALSPVSPVAGSQPLTRSSEAPVQAPMPQRPAELRQSVNLRLHEGKPHASAHGAPEKEKPKTVKVAKDMHDGALPPVYKRQATDPIVSSQGTAFAAGARECGKCGKKLGTQGTGHGCHHCGQRTTTGQASTAPPTAPAPVHTPSAHARAVSESQASHSSSRMSELSTAGPSSSPSSSTHTRCCTKCGRYKRPSLEASPFDQGRPNGSGPARAPVPMSAHPAMRPNLVVQPNAPANNAVYPKIDVIPPSAATYRTVNSPYTPYGDDSPLVGQAKKEEFRLFRNSSLVRSLSRRLSRKDKNVAAPAPLPSQQLARQSGEQSAGNLINMISNAMQGPAHEREGQYSKLDGDRPETPFSFVGGKDEADGFEMVNIRGDRASVSSHDSWSKEPIAPQISVTHSDSDMYAGIPQDHIDVAPRPRSTGPQRLAVDDVSRPPITRFKSLRQGVQRMGSGVSRSTSLKRLGSLKTVHHAWYVEGTDGNNENMIPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVU2</accession>
    <name>A0A1C1CVU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11096"/>
    <dbReference type="OrthoDB" id="5218421at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="82" mass="8923" checksum="CA83256DAD57524E" modified="2016-11-02" version="1">MPAAVEYLTSPQHETLDYESDPIAAMTSYSRMMHSHTKSQMDAATRSARRRSSSSSTGVNAHANTGLSKQNTHSSNSSRSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW72</accession>
    <name>A0A1C1CW72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW72"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09985"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04140"/>
    <dbReference type="OrthoDB" id="4147290at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="495" mass="55478" checksum="E0F5A152CB5C684F" modified="2016-11-02" version="1">MNSRRGELIRRHTRHLSRNNSYGDPNTDDDSENSRCPSPLLTVEAGYRVDPFMRYPVARVTRGVRFMADYYIQIWAPQQAQASSVQNGRNALLALILPLAFQNSMLFEATIAMTRAAWVLRRGTEPFADKMLLRHRGTAMKELRDVLVAPHPPSQDLVLLTMSTFLTLNYMIDDVESFEVHLRALESMLATTTGDGDVRNFVQGRALAFGVMASFLRAHQPSYASRINEKGHRISTLTYPGHPFSPDLCAVIARLPEGFAEVALSRCVAIEIISFLARLTELITWIATREGPADQSTTPPPPPPATDESPASAPGPTPTRPDMTIQRAIYDLQCLSALPLTPPEGQMVRALLAFCLHLYNQTSFHIPLARPLRPVLEAFNENTELPRPPWLQRCLYWCAVVVASAWDTQMDASPERHVVLDRLAARLPEARCWADTEDLMRKFLWLDRLADEWEVCWRAAAFRSRRQRRGASQIASAFALGDREDAGGVADAFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWA6</accession>
    <name>A0A1C1CWA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWA6"/>
    <dbReference type="STRING" id="86049.A0A1C1CWA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11116"/>
    <dbReference type="OrthoDB" id="4138941at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8272" checksum="98CC45DD80EE8A55" modified="2016-11-02" version="1">MALHGLGISHGDVKPDCFHPPGSTHDIALYDFSRSYTFSPERPCLTNGTRRLRTLKRAEKVDCRNVQKTVLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWD6</accession>
    <name>A0A1C1CWD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWD6"/>
    <dbReference type="STRING" id="86049.A0A1C1CWD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10127"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04204"/>
    <dbReference type="eggNOG" id="ENOG502SJ55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF29">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="29"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="443" mass="49818" checksum="DB58599BE1FBB77C" modified="2016-11-02" version="1">MGSEHYPVKHSGIYHNLPVFDPAIKNLTAIVTGANGISGFHTMRVLLESPERWSKVYALSRRPPPKEMMGLLKPEQRSRVQHVAVDFLEDPKKIADAMTSAGVKADYIFFYSYLQPRPPPGAVVWSNVDELVKVNTALLDNFLGALSQANIVPKRFLLQTGAKHYGVHIGRTRVPAIESDPPPAHLEPNFYYPQEKSLFRYCEANKTSWNVIRPAWILGAVNNAQMNALHPFAIYAAVQAQKGEPLYFAGDWDSWQGESHHSSAMLTGYLSEWAVLEDKCKNQAFNSQDTGTVSWDRFYEELVRWFGVEKGIHPPEEDLSKFHEFKGRSGKDTPMGYGPASVIRSLFSLVDWAKKPENKEAWQQLMKASGGQLTDDPFRDPQANFEFGDAAFLRVGSLAMNKARRMGWTGFVDTIEALFEMYSEMGDLGMVPRMKVDAAKPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWL2</accession>
    <name>A0A1C1CWL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide chain release factor 1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MRF1</name>
        <name evidence="6" type="ORF">CLCR_10153</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWL2"/>
    <dbReference type="STRING" id="86049.A0A1C1CWL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10153"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04186"/>
    <dbReference type="eggNOG" id="KOG2726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000070">
        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="5">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT52845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="416" mass="45540" checksum="FCA0DA1DFD3D9AD8" modified="2016-11-02" version="1">MYVTFYSTRPPSTAAGDGADLSPILLRRARTVAAEHQHLSSANAENYDVAVAKKIGELGPVVAALKEWEDAQSSLAELETMLTDPSSDAELRTLASQDIEATTSQLPSLSARLKNSLIPPHPFASLPCMIEIHPGAGGSEASLFAQSLLNMYTDLCARKRWPTTLASYTPDDSTHDAGLTDALLEVHQPGAYDVLRTEAGVHRVQRVPATEKKGRTHTSAVSVMVLPSLPDSSSSSSSSGSTTTDAELDYENPDSDYYVNPADVKSQAMRASGAGGQHVNKTESAIRLTHLPTNTVVAVQEERSQHKNREKAWRLLRAKIAQMRREAREEEIVRIRRSAMGGVARTGREDKIRTYNYSQRRVTDHRSGMDSSDLEGILGGGEGLEDLMDSVREWMAEEEVKGLIAEEELRQREQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWS3</accession>
    <name>A0A1C1CWS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RSC complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_09571</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWS3"/>
    <dbReference type="STRING" id="86049.A0A1C1CWS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09571"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04343"/>
    <dbReference type="eggNOG" id="KOG1827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04717">
        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000015">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit RSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000048">
        <property type="entry name" value="RSC complex subunit (RSC1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="88"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="298"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="11">
        <location>
            <begin position="403"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="558"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="634"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="736"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT53003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="856" mass="97442" checksum="A43CB1C49A297C14" modified="2016-11-02" version="1">MADLNSADAKASEPVQSIEVEPTTKNEGTADAKDEGAADDNADEDAEADEDDAPGEEGDGRPVSRDQYKALKNIADILTNHKIQVKNEDYFPSQLFKRIPNRRVLPDYHEIIKDPVAISTLKQKIQRKQYTGIPEFVRDFALIVHNAQVYNRPNSGPVRDVFLLQDVFKEELKKLVDEGLIKEEETVFPDLGEIPDATPEPTPVSEDEEDNDDEDEEDEDDDGADDDSEDGRRKRRRRGGRTSISGRKGRDDDDKAGEPKRRGRPPKVDTPMEARIKAILKGLRKPKDKAGNLKIRHFERLPDKQEYPSYFAEIKDPIALDMIKKKAKRKKYQSIEQFMKDIDLLFNNAKQFNEDGSEIYQDAADLHTEAQKLVEIEKAKPDDEYLMEDGRRPLPNGILHKNELWRVGDWIHLQNQNDVTKPIVAQIYRTWEDTEGQKWINACWYYRPEQTVHQYEKHFWPNEVVKTGQYRDHQIDEVLDRCFVMFFTRYTRGRPRNISPTTEVYVCEARYNEEKHRFNKIKTWASCLPDEVRDKDYEMDLFDNPRKIKKVPSPLKHLLKDDMTDSGPLPTPQWGHPNAPPIIGGIHKQPREENQSPPPEPTPPPPPTPPPPVARQPSMSTVTSMAPRPVVNGASHTPTLQPQLTRPSPSLTPNPYQHQSISPAPQYGRQNSFAQSQTTYRANIAPSTPALQQNHHSYTTHQQIQPQPSLTPARPGSYTSSATPSHSQAAFGRPLYQQQTSTAAPTSQSYPNYSSATPAAASTYPDHRAGDVFVLSDTANASIPKSIRDKFPQDDQGRVLFFTKPPVVHDLTVRGKEGQVLKHTERYLKAKAEREAKKRARDLERTRMEAAKRVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX29</accession>
    <name>A0A1C1CX29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">for</name>
        <name evidence="11" type="ORF">CLCR_10052</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX29"/>
    <dbReference type="STRING" id="86049.A0A1C1CX29"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10052"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04418"/>
    <dbReference type="eggNOG" id="KOG2467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="24"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT53084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="476" mass="52570" checksum="DE9C29605A7AF236" modified="2016-11-02" version="1">MGSMAASSYALSQSHKDMLEKSLVESDPEIAEIMKKEIKRQRESIILIASENVTSRAVFDALGSPMSNKYSEGYPGARYYGGNQHIDSIELTCQSRALKAFNLDPEIWGVNVQCLSGSPANLQVYQALMRPHDRLMGLDLPHGGHLSHGYQTPQRKISAVSTYFETFPYRVNLETGIIDYDRLEENALMYRPKCIVAGTSAYCRLIDYARMRQIADKVGAYLIVDMAHISGLIAAGVIPSPFEHADVVTTTTHKSLRGPRGAMIFYRKGVRSTDAKTGKQVLYDLEGPINFSVFPGHQGGPHNHTITALAVALKQAASPEFKAYQEQVLKNAKALESEFKELGYKLVADGTDSHMVLLDLRPQALDGARVEAVLEQINIACNKNSIPGDKSALTPYGIRIGAPAMTSRGFGEEDFKRVARYIDQSIKLCKKVQGELPKEANKLKDFKEKVAGESVEEILKLRQEVADWASSFPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXM7</accession>
    <name>A0A1C1CXM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Smr domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXM7"/>
    <dbReference type="STRING" id="86049.A0A1C1CXM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10034"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00171"/>
    <dbReference type="eggNOG" id="KOG2401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058864">
        <property type="entry name" value="UBA_10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26286">
        <property type="entry name" value="UBA_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="118"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="435"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="524" mass="56558" checksum="F8CCF5CA7AC357E8" modified="2016-11-02" version="1">MGEMEPRVAELEALRATYCPPLDEALFHAIASDYTLPQNKAALIAVLDDLAVGALEQEDTEFDPSGTGATTQVRDTTNTSRSSPEESFSNGVTSITTCPSEPRSSDVDSLGHGLHNSSEGQKTTWLENMFPGIPRRELTSILASHDGSLDKATDELLNLSFLKQGYEEETEELPAPKGVDGLAEEMQSSRKSRKRRKPRTNDSSRGSSASSSLHKSEHTPVNVWSTMSEDVDFICSRTKLHPQTVRSEYHLNGARLSSTIRALATKEAAEHNRVSDTNHILDLQIAEFQHRYEHVPVSQLCGLLSLARNIPSAAQELLEAMTVVDDTTKPGKLYDVAQYTPIDLKENQPFETPSSSKQTSVTAQARASAASQRIAAGQKFGQASAAYKKSKSNPLFGGAAAYYAEVAHEQLKAAKEAHAAEADALVSNQSSANVLDLHGVSVQDAVRIASAKTQSWWDGLGDAKYATGGGGPARVGYRIVTGLGTHSKNQAPRIGPAVSKMLIREGWKVEIGHGELIVTGKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXN5</accession>
    <name>A0A1C1CXN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF2 family N-terminal domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_09480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXN5"/>
    <dbReference type="STRING" id="86049.A0A1C1CXN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09480"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00180"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000053">
        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="449"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="923"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="761"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="841"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1094"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="765"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="844"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="873"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1121"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1172"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT53218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1186" mass="132210" checksum="4EEEDAB85B748E4A" modified="2016-11-02" version="1">MPPRPGTEASDLRGLSFEELRRRSTSNSSPAEIARERVREYHTTSPAGGIEVSRSSDALVKNHFVAPDNGICCAQSSLPLPASSPPPPHDLEPGSGVYRPTFPFFGRPFQPQVTPESSLSAPPLSVDFTFALPVEMVREHQPARNPLGPAMGNSQPPPEPQDNDKKTGTTEIPASRPLYPSLQNAFPDQPQFGRPSMPGASPQPYSRTQPLVRPNSSAPRQVSGSQPRDKYSNLFVSAKNPSQRPELHKPKATADPLQAFKSSQTATQPTSLTSSRPGSRDSDLYEITKPANLPSWQPKPFVPPTFSSHQPPNQFFRPQNVVDLTRDLPVPHRTTYPSNDSYQFDRFEATDPFTYMDSTKANEEIKALLEGALEDEEDIPRTRRRKKQLDDRLEDLANKVKNLGVTSEDKTDDPGQEKVDEEDDGTVEGLKVKLLPHQIDGVDWMVNKETGKNPTKGGILADDMGLGKTIQSIALILSNPKPSGEEVAGAKRKFPEGVVKGTLVVAPLALIKQWEGEIKDRVEEDHALRICVHHGPQRAKSSKDLKKYDVVITTYQTLSSEHGGCSESLRVGCFGVHWYRVMLDEAHSIKNRNAKATKAACALDAVYRWCLTGTPMQNNLDELQSLVHFLRIKPYSELEHWRENITRPMNNGKAGLAFRRLKLILKSFMKRRTKDILKQDNQPKDGRTRGKNEGKDPGFKIVARTVETVEAEFSPSEQEFYNRLESRTDRSLEMMMAGNKMSYASALVLLMRLRQACNHPKLTGSDLSTETDAASGSQTPSRRKASVEDDMDSIANMLGGLSVETKKCDMCLTELTAGEAAKGAIRCVECQEDLDKQNDQVKTVMKKKKEKRRKSEVKTIKKQRKVARRVVLDSDDEDDAETPEDDEDVSSLSGEDEDEDEDDDYASSDESDTSQPTIMQSTKIRHLLHLLKEDSHTHKYIVFSFFTSMLDLIEPFMKASRIRYVRYDGKMRNDAREAALHALRTDPSTRVLLCSLRAGSLGLNLTAASRVVILEPFWNPFVEEQAIDRVHRLNQTEDVKVYKMTIKGTVEERILDLQEKKRELARQTIEGQAGKKKALGLSLQDMMRLFRRDAEDETPVDVEQVGKGRSKGLLERRGDIPTTNPSSGAGSSQTTNTSLGPNGEDRGHAHAPRRGAGGGGWSSNKPRVSGEANKRNENPVFGRRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXW7</accession>
    <name>A0A1C1CXW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10807"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00338"/>
    <dbReference type="OrthoDB" id="5596743at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058645">
        <property type="entry name" value="NTF2-like_dom_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26534">
        <property type="entry name" value="NTF2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651130" description="NTF2-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="NTF2-like" evidence="2">
        <location>
            <begin position="51"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="191" mass="20968" checksum="C4F3744920407244" modified="2016-11-02" version="1">MHSTILASLALLTAAFARPHADWSSSSADVPAHGDDNGSYDQHYGHGMNDKCLNKGDVQTLIDGYTYLLEYPGGPEFNKTANSILSDKFVVWSDSINTLGNRPAFIASQSVTPPLPDVETLSTFHNCDQISWRWNATGIQNPQVKVSNPMPVLGLITFSVDVEQKKIDTVYSEFNTAAFLHDLGNPECQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY50</accession>
    <name>A0A1C1CY50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY50"/>
    <dbReference type="STRING" id="86049.A0A1C1CY50"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10997"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00430"/>
    <dbReference type="eggNOG" id="ENOG502S45I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5587367at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051614">
        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="115" mass="12369" checksum="0C4731BEE80E57B4" modified="2016-11-02" version="1">MSSEGISLATPPKCTADFCLIPLGTPTASVSAQIAEVQRLLKKSGLKYSMHSAGTTVEGSWDDVMRLIGQAHTLLHEKGVVRIQSDIRVGSRTDKAQTMEDKVMAVEKLLAADNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYI8</accession>
    <name>A0A1C1CYI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_10473</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYI8"/>
    <dbReference type="STRING" id="86049.A0A1C1CYI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10473"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00562"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="101"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT53607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="235" mass="25074" checksum="2CEE63E791426C28" modified="2016-11-02" version="1">MSPTKERKPFRARQGEQKRHPGDGRRAMGVYWVPSGKASGMRPLPLLSLPPICAALVDLLSPSTSHSPPVVHLNSVQSHLSELTPIFVSRLRSDLTAAIMSEELTYAEVSKHSTKKDLYLVIHDKVYNASTFVDEHPGGEEVLLDVGGQDATEAFEDVGHSDEAREILEGLKVGSLKRGPGDPAPKVGATDKIAAGPGGRSEAGTGLGIAAYAVLLVGAAVAYFGYTYMQSQDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYL2</accession>
    <name>A0A1C1CYL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10966"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00455"/>
    <dbReference type="eggNOG" id="ENOG502RPW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4142992at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="146" mass="16335" checksum="6A8F2EC7058F03FF" modified="2016-11-02" version="1">MCQTETFKSHTCPHQWMTIVKPCGPKASFKNQYHTYEPVRRGLKKLIQPGAIPAPANSCPNCDKKGDYDANMTRIIIQNPWEAGNMGNGYNMTDGRGNVLHTRYAYGAYGPPGARYTACGVTRASVPRRQPQPQQPWEQDGCCRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYT1</accession>
    <name>A0A1C1CYT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_09670</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYT1"/>
    <dbReference type="STRING" id="86049.A0A1C1CYT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09670"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00640"/>
    <dbReference type="eggNOG" id="KOG0003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="580"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="690"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT53699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="765" mass="87316" checksum="D82D9E52FC164F76" modified="2016-11-02" version="1">MAHKDTLFRSASMSLTQLYISNEIGREVVSALGEIGVVQFRDLNSETTAFQRTFTKEIRRLDNVERQLRYFKSQMEKSGIEMRSHWDFDENMLAAPQASEIDELAERSEALEQRVSNLNDSYETLKRREVELTEWRWVLKEAGGFFDRAHGQTDDIRQSIDDDDAPLLRNTEAEEGRANGDVAQQQSFAVMNIGFVAGVIPRERLAAFERILWRTLRGNLYMNQSEIPEPIINPENNEEIRKNVFVIFAHGKEIIAKIRKISESLGADLYNVDENSDLRRDQIHEVNTRLSDLASVLRNTKNTLDAELSAIARSLAAWLIVIKKEKAVYNALNMCSYDQARKTLIAEAWCPTNTLPQIRATLQDVNDRAGLSVPTIVNQIKTNKTPPTYNKTNKFTEGFQTIINAYGTAKYQEVNPGLYTIVTFPFLFAVMFGDFGHGCLMAMAAAAMIYWEKPLLRSKQDELFAMAFYGRYIMLMMGIFSMYTGLIYNDVFSKAFTPFASAWEYPEDGRPEVTGHLKGSYRYPFGLDWAWHGSENDLLFSNSLKMKLSILMGWAHMTYALCFSYINARHFKSPIDIWGNFVPGMIFFQAIFGYLSFCIVFKWSIDWPAEGRNPPSLLNMLIQMFLAPGTVEDGEQLYSGQAGVQVFLLLIAVVNVPILLLLKPLYLRWQHQKTAAQGYRGIGDTSRVTHATDLDDDDDNHHANDRHANGRPSEDDDEGAMITENIGDDEEEEFEFSEVMIHQTIRKPVHPLVQGLPADMFRRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZP6</accession>
    <name>A0A1C1CZP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CLCR_10754</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZP6"/>
    <dbReference type="STRING" id="86049.A0A1C1CZP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10754"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00831"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000328">
        <property type="entry name" value="Cyclin-dependent kinase 20 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="4"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT53916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="223" mass="25028" checksum="5833BEB95322C4E9" modified="2016-11-02" version="1">MENYQKIEKIGEGTYGVVYKARDLSNGGRIVALKKIRLEAEDEGVPSTAIREISLLKEMNDPNIVRLFNIVHADGHKLYLVFEFLDCDLKKYMEALPVSDGGRGKALPEGSTMDMQRLGLGKDMVKKFMAQLVEGVRYCHSHRVLHRDLKPQNLLIDREGNLKLADFGLARAFGVPLRTYTHEVTNAWNFSFATAFAHLATRSSHYGTARQKSFSAAGNTPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZT9</accession>
    <name>A0A1C1CZT9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">APT1</name>
        <name evidence="14" type="ORF">CLCR_10732</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZT9"/>
    <dbReference type="STRING" id="86049.A0A1C1CZT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10732"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00973"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="13">
        <location>
            <begin position="96"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT54073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="237" mass="25325" checksum="364EF85347A095C1" modified="2016-11-02" version="1">MTLPGDTDPSHGTARSEPNAAATTSLTAIASQLTGAEALSELRSLLKAGLKTYPDFPKVNACRITPPDLSLTRWSKEGILFEDILPLFASPSLHQALIRAYELQIIETLGRDNLPDVIVGLDARGFLFGPTLALRFGAGFVPVRKAGKLPGKIETAEFQKEYGTDTFAMQTDAIKPGQKVLVVDDLIATGGSAAAAGTLVEKCGGTLLGYFFIIELTFLRGRDKLNAPVYTLLESQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZZ1</accession>
    <name>A0A1C1CZZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZZ1"/>
    <dbReference type="STRING" id="86049.A0A1C1CZZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00184"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02569"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF100">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G01490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="82"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT54129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="296" mass="32427" checksum="BC7E1BEE18AF0546" modified="2016-11-02" version="1">MKLPWTRLIRFVATDGRTLRGEPILPSEDFDLGNVTEADKLQAKVITGDDIFDTSGKTKVTDEVVSVKKILAPLTKEDVPVIRAIGLNYAKHIKEAGRQPPPFPFFFFKPNTCLQDHDAPVVIPKIAQDEQADYEGELCIVMGRDAKDVSREDALDYVAGYTAGNDVSSRKLQRDPELAGRIPQWGFSKGFDTFAPVGPVIVSSELIPDPAQLHLKTIIDGETRQSESVSDLLFDCAYIVSYLSQGTTLQKGQVIMTGTPGGVGFGMSPPRFLKPGNKMEISISKIGTLRNVVEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0D2</accession>
    <name>A0A1C1D0D2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rrn7/TAF1B N-terminal cyclin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_00315</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0D2"/>
    <dbReference type="STRING" id="86049.A0A1C1D0D2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00315"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09408"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048540">
        <property type="entry name" value="Rrn7_cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20644">
        <property type="entry name" value="Rrn7_cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rrn7/TAF1B N-terminal cyclin" evidence="11">
        <location>
            <begin position="78"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT54166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="241" mass="27437" checksum="541FD0075E6D157D" modified="2016-11-02" version="1">MDGDECATCGSTDFHDEDGRIFCHNGHDQGHGLSTAEDDADFGRQGTIVRKKVDKEKQKTSRVLRGTKAFQLFLQSWQFILWKQCHALVHQKGLPAELWSVVRDMWTLWVSRLEHRLLQDPTTAAVDELTDTTADKADTTASSGDESDIDPRTSVQKQLQKNEEKERDSAHDYPKLIDTIALAYMGIIMLRRPVGQAAFLRSTPSEALDSPGENSRGEKGYRRPGHWRRLSRKLELLFLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0D7</accession>
    <name>A0A1C1D0D7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor 38B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0D7"/>
    <dbReference type="STRING" id="86049.A0A1C1D0D7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10110"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00979"/>
    <dbReference type="OrthoDB" id="2431475at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="57115" checksum="9937538C2B5BE9CD" modified="2016-11-02" version="1">MPSTEALDDDDLAALLVADARQSSLRYASQGLSALLPRRPSNSAAPKPNTRFLKNLVRDADTHNAKLKEREEAEAHERLRKIREEERKRERERAYELSGERQRKRRKLSGDGHHDRKQSRRHPHEGVRNSTRADSPRRERRREQHDDNHDRERHQRRRHQQEEKHGGHARRRRGRDTLSDDDDDGTTHRTARASRSSRRNRSRSRSRSRSKSRSRSRSGDRKHQRRPAQHKTEQSRPSSSSSSSLTSDPLSSLIGPQPASTSAHTSQSRSQSQSQSQSPSYVRKRGRGFTSTASSTTLSNSRDPPTSNSNSNIDTHFAPTYNPSADTTDADAAGPDLDDEWTSALSALRHRQSYRAKQALRLREAGFTDAEISRWNGALHRDGVPDRDTGDVRHVKWRKRGEEREWDVGKAALGFGPAAASDDEEKEQGREQEQIINADQERKNLEPNANASSNVDTITEHEQRRRNRKERKAIIKAGGDEVSAWHRPQSGLLKQFKSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1J8</accession>
    <name>A0A1C1D1J8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial resolvase Ydc2 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1J8"/>
    <dbReference type="STRING" id="86049.A0A1C1D1J8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03011"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04712"/>
    <dbReference type="eggNOG" id="ENOG502S4DK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5552842at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000402">
        <property type="term" value="F:crossed form four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16963">
        <property type="entry name" value="CCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039197">
        <property type="entry name" value="Mrs1/Cce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015242">
        <property type="entry name" value="Ydc2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072:SF1">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09159">
        <property type="entry name" value="Ydc2-catalyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial resolvase Ydc2 catalytic" evidence="1">
        <location>
            <begin position="59"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="322" mass="35457" checksum="050D9B57B2558AFD" modified="2016-11-02" version="1">MPLAKPWLDTLTTAKLHRLAIAIGAPCSGTKAVRIEGIRRAVTGVSSKDGGDASDLSLLSIDMGIRNLAFAHITASLQAANSAKYLQYTKPTLQAWRRLAVSEPLDVTNAVPISVRVGNASEVLASKESFEPVDYGLHAYKLINYMLQTCQPSHVLIERQRFRSGGGSAVQEWTIRVGVFEGMLYASLRTIIEERKLHLSVEPMQPSRVNRYWLEDCMRPSTRKLVGQEVKRAKIELAGDILREADANICVGNEMQPIVADFVSGCNKDSKSKPAANTGKMKLDDLADSLLQGLSWIKWQNNRRRIEVLGREAIDLDSGAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1P1</accession>
    <name>A0A1C1D1P1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_02737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1P1"/>
    <dbReference type="STRING" id="86049.A0A1C1D1P1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02737"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04707"/>
    <dbReference type="eggNOG" id="ENOG502QT5J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5244761at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="438"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="906"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="922"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="985" mass="108777" checksum="F71AEC264E5CCDAE" modified="2016-11-02" version="1">MDEVGDVDIKHERSNLYGHPPPNHIHRMPPAETPTSYSYPPPPGAGMPPPGPAWNPTPSPYNDSAEHRPPPPDMAHPSPYPPPPPPQSYPPSLPPPGREPPAYPPDPGYGRPGSVSGPTRSPAEVQQPPYHPVSTNPHEPSYYPPPADYRPRHEYPGPPPQPNGTHHQPPLHVLTAGHEMMPGQPPGPPNYGPPSAGPPPSAGAYPYVYPAPYNDQQRRKAVRAAQACDSCRQRKAKCDEGRPECQHCKDNGLKCSYREIPPQKSEKQVLQITAQLDSLAEDVKALAQKSEEREEKIDQFLTQQNEKMSMLLEHFMQSRQTPAATMDVAMTDPPSHTPMRTQERPSPAQPPPPPFGFRRQDSSEVRFGSQAQNPSAASIQHMRNTEIESLEDTPMPAKHTTAAQNLVLWPSIKALIPRGITPSYVMDEETSRGLLRLYGCGEGEDKGDGHEGAPSPAHSNSSEGRRMEEESASPHGVWGSGQLHVPMSNQNQTAREHPGGLSPGGGLMLDSEAVDKYFRSFMEHMHILHPFLEPKVLRNMVHAFKRKYSWDYRATQQIAAIGNKRKRETTDSPKSIDDYNRQPTKVYNASHVPPIEHSIANAIVLLVVALGKVCSHREPLPGPASTAAMRTSTPHSALYSDLPLPASAPTSPYTNQATMNGTVSSPANPQGKNMDIIPGLAYFAKAADILGELPGGADVSHIQAYLLAGLYMGQLARIIPSYFYINKACIAAQILIESTPYVTNTMKPARRNLINFAFWSCLQLESDIAAELELPLSGIGRYESPQHKEFPTKITLDAIPESSADDDILRFYSYQIQLRTTMNSVHATLYRESKNLQTRPSDSIMSALDDNLENWRKMLNDWDWDDNDHEHPNINVARMRGKYYGAKYIIWRPTLRFALLQAIHGPRPKRPSESPAAYGQGSEVTSPSVSNLNSSQPGGRDIPFIRPELLEGSRKCIEAAIRSTTSFDKVPRRLVVTNIFGTTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D292</accession>
    <name>A0A1C1D292_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D292"/>
    <dbReference type="STRING" id="86049.A0A1C1D292"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03122"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05097"/>
    <dbReference type="eggNOG" id="ENOG502S7RW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT55003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="21591" checksum="345CCFE129466FEA" modified="2016-11-02" version="1">MAHAERETLNGPSIDAMLRGLTERPNVQSTLILSRKDGSIIRATGIGLPEERGDTTSAGYQWSQVPVSAGGLEGSERGGASIAEKSEESTEAPQSARPVEILASSIFQFVNSANVLGETLGATSRGGPRTNGTFTAKAYGEGTDSANNERSSEEDAESGPGEDEVQLLRLRTKHQEIIIFPDPNYICCVVQKMSKAGNAPNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2I0</accession>
    <name>A0A1C1D2I0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2I0"/>
    <dbReference type="STRING" id="86049.A0A1C1D2I0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03177"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="137" mass="15545" checksum="65B0CC68EC7A855F" modified="2016-11-02" version="1">MEMQLRLYVLADRLQAVMLSGIILCEPPIGLPAGSSMKDATRETSPETQDPEILYRTHCIPRWGERRRVHRLAFRSVTDSRGLSARSMLAKIFADMMNKYDTVVMEPTEENGSTVMSFFDPRNVLAGSRDAKRARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2J1</accession>
    <name>A0A1C1D2J1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2J1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02850"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05092"/>
    <dbReference type="eggNOG" id="ENOG502SKDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5086080at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF7">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="66642" checksum="C05F2AABC5C59187" modified="2016-11-02" version="1">MSPTGPVSNTSSRRTTASSQKNADQAQDGPLAEAKSASDEVTPKRPKRTLKLTASQRERKRAIDREAQRSIRLKTKNYIAHLENLVRIMENGGSSTNSGGGIQQSNDYPAAEPEGERARALLSQLRQSEEEVRALKEMLAGVQKLVGNALDPADAPGWLGTPSTGNGEHAAPPANPLACGPHDQFENCPSVYSHSSDSSSPLVEFGYQAPFDQPGRAKALGSEYPPRSYGVQPYTLQQQDLYNSFGRVSAPVPRPDPPTSDPTDANNGREEGELFFLSDREVNRVLAGGHQSFANQPLDEDIIVRAVLHGWRDVQDQYLLDKGWQALRSIDQTIFRECGVVERMAILYMMRLKLLHQSNTNPQYLAPLPPFFQRGSSEDPETLRKTPIIEHFIWPGLRTNLCRNTKKYINNKFSDSFRQSFKFIWPYDISHTYNKDHSTQLYSITSGFKQRQWDLRSWTMRKGFFTHASELIGSIPVYETPMDRILIPAGSVAVQPASQRAQAPRPLTKMEQSEAEQPPICMGEGNSQAPSAAGAPAPAPAHIQGPVPATAPNVPGSHVPYAAEVEAWLGDPDMVPQYWNMSTGMAVGYGAAAQPWPGVQRGFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2R6</accession>
    <name>A0A1C1D2R6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2R6"/>
    <dbReference type="STRING" id="86049.A0A1C1D2R6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02714"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05116"/>
    <dbReference type="eggNOG" id="KOG3687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1128"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1358"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1374"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1390"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1404"/>
            <end position="1419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT55024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1419" mass="158295" checksum="820B5FB67CC47BD4" modified="2016-11-02" version="1">MSRDNGSPKEGSAPPNSRDSRRVSLWHLPVASRSSPSPDGHALSGQTPEKPVSHTTPLQLRDVIKEGLSVATSPEDARAWLVGFGDLNPGTDVSRRFIDLREDHHGDQGTTSLLSLLIQWLPTWAQKAGKARKENKTSRSASLKDHKNLDWLLQYISDYLELGHTGFDPQELSRTVEAITTLCLNANRQEDIDAGVSILYIISSHFDYPPSGLDQTLVVLCASITSLSEVPRHLFDCAKLLATSGLHAGFMSTLYSFVRTPISESPRHYLSHARGATRILQHLIDERQEGGGFVLSLQDFLEVLHPAAQQGISRFCYDILNALHAIMSSHRSQTEMPSLDFGMLLETVRLCFEATSPRSQTQDEDRQWEHHSRDRETVSKKLAQDFLRIWDRLPSSDQIAIHELFLHFPHYADQSQLILSLNYASANYLSSEDDNIKSQYADKIYKEIVQDQALPSAARLRAIEILVQAGNPFNDTMAEPSTFPHEVYVSIFGGLLDQLDSERDTRVFETLLRSLDHMVSNYEEAAKEKASTIRTIEKIRGRLMKDAPAGESLNDDLAILATKVLITIFSYSIHTDADAAVKVFDALVEAASARCQSRPARLVAKRLLFRIRADDAGFIYIATGSQSRHIASALVRTRESADTFKLEIPSQRDSASSTSLSARSDAGDPLWMYPETEDVNYPFAGRASRILNVSKTAYPQVKEGLDMNIWLMSIIRCLQADQDWETYGYTVVHAGAQLSNIALWLNSIQAIVKLRQVLCEQIVNNSFREPPTSTGLKRSDVALCMYDILVNLTPFATMRSEEVQKGFGDDMVRAFISGLGGAWEGTSRGCIHALSLCSLEIPSSVATLYPTIIDKMSKNMTQGHLTAHILEFLIQVALLPEMHSNLNPDEIQMIFGICIQYLEKTRAQQQSTVTAPQGRVSAPSRHSGMNFKRPPYRAAMLTDIGLPQYAAALAYHNILFWFLSLRLDLRAKYVQWIVPRLVWKNGRGEEAIDEQGEVLIDMMQRTAFSDLGETSPNHDFAGSEDGPVSSASWIAGLSIVTVEVAGHTGKTHITKRQASGTTYAMYQQLTAPLPSHHRPGHTQIRQQEITTEVLPPHVMLQRVASAAITNLADQPLLLPQEEYVQRALEGFDRIPTVTSHKFGVLFIDEGQTDESEYLPNTGGSADFERLLEGLGYVVSLEPPLQFKPQGLEYPRDGEHTIAWRDRVEEIIYFVPTMMPNDVEEDPQCINKKAHVGNCHVNIIFNRSGLDWDMNNLKSQLNYVNIVIRPACRSREVKDPDFLPGFYWVRVITRDDLPNISPAADAKIISAAQLASFVRTLALNASMFCQTWNTKDDDTEFPSAWRARLQQLKRLKERVMKAADKQAPSGGATMPSINTPPGTSSGRKTPVPREEPGGAKKDGSLASQLDFSSWTIHTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2Z5</accession>
    <name>A0A1C1D2Z5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2Z5"/>
    <dbReference type="STRING" id="86049.A0A1C1D2Z5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03044"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05081"/>
    <dbReference type="eggNOG" id="ENOG502RXJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2106152at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="318" mass="35888" checksum="A642F34F254C561A" modified="2016-11-02" version="1">MVSSTPYLDALQRDGFVKIPNLLPQHVLLAMQATCKYTTDRARQGKWPHVRTVPKQYPPWHEWQPGDHIWGVQHLLHPDMPTRDTFAEVYFGDPVLDVVKELVGLKDDDNDEDDDDGLVMELFNLLVSPDGGRDFELAWHRDDVRPDVTPEEEARQLNVNFDSREEEEEEDRRPQLHAQYNIALFEDSSLVVVPGSHRRVRTRAERDAAPYEPNLPGQVVVALQPGDAVFYDSNILHRGVYRAIDAATELGRMTLHGSVGLAGHGTERARQVLQHGVGEWVGRAKFSIEGAKGERAEAMRKRLMDMGSGKDLGYSLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C638</accession>
    <name>A0A1C1C638_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="1"/>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000023">
        <property type="protein sequence ID" value="OCT43973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C638"/>
    <dbReference type="STRING" id="86049.A0A1C1C638"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11475"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT43973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="187" mass="22428" checksum="5014C07C7F8BDB18" modified="2016-11-02" version="1">MDKSNNFDNTDSLKHFPSSTRYWDSSIFMYNNNTLSLTSNISRLAIKFIRNYFYLYNRIIEGKIRRKKIYNRRRKLSINRIFLSKGEFKHTNNKVIITLYIYNRQKDNYLLKLKKRYINKFLINILSFKKNNTIKSLSSRKNILSNKLILLKKLKKISINGTSGLIDANLFEPRVARILKDLYQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6G6</accession>
    <name>A0A1C1C6G6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DIN4</name>
        <name evidence="6" type="ORF">CLCR_00651</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6G6"/>
    <dbReference type="STRING" id="86049.A0A1C1C6G6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00651"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01071"/>
    <dbReference type="eggNOG" id="KOG0525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="67"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT44135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="391" mass="42604" checksum="83A7A459056328CB" modified="2016-11-02" version="1">MFACRRSSSVLRALKPTAIQLRHASQAPSTAQLNKPIDFKKTAILHQSQTSARSAFGLSQDAPVDWVNLHGAINASLHHALKTDENVLLFGEDVAFGGVFRCSKGLSDEFGTSRVFNTPLSEQGIVGFAIGCAAEGMKPIAEIQFADYVFPAFDQLVNEAAKFRYREGGTGGNCGGLVVRMPCGSVGHGALYHSQSPESLFTHIPGLRVVMPRSPSQAKGLLTASILSSRDPVIFMEPKVLYRAAEEFVPRDPYTLPLDKAEVLKTGKDLTIVSYGQPLYLCSAAIEALEKEIKGLSIELIDLRAIYPWDRATIMESVSKTGRAVVVHESMYNAGVGAEVAASIQEKAFLRLEAPVARVTGWSTHPGLVFEKFNIPDITRIYDAMKRTLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6P4</accession>
    <name>A0A1C1C6P4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_00675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6P4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00675"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01137"/>
    <dbReference type="eggNOG" id="ENOG502RXWC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2556122at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045226">
        <property type="entry name" value="Dsc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025390">
        <property type="entry name" value="Dsc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019413">
        <property type="entry name" value="Dsc3_ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN YOR223W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13373">
        <property type="entry name" value="Dsc3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10302">
        <property type="entry name" value="Dsc3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="DSC E3 ubiquitin ligase complex subunit 3 ubiquitin-like" evidence="3">
        <location>
            <begin position="27"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DSC E3 ubiquitin ligase complex subunit 3 C-terminal" evidence="4">
        <location>
            <begin position="207"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="36430" checksum="8AB50C3B88A62463" modified="2016-11-02" version="1">MSLKPPPLRPQHDEPHDYSHVHDADLELTIRFSASLPDLLLSIPASLNANTATLKQLIRSRIPEQYAKHRIRLIHAGKALVDDVPLSTTLKRNVSRPPSRISTPGPYDERNNGPTTASRGGPADGGDGKGKGKQPIRDAPAAQPRIYIHCSIGDIVLSAKELADEAAVAASGAAQATTEDGNGNGDGNGIGEPKTKGAHTTTTPAPRGFDRLLNAGFSAAEVQSLRLQFLAIQAHTHTPDTMPSPNTLRDMEDRWLDNSTADFGGMGGLDGNTAGGVGAHDDDMQAGALDDMIWGTAMGFFWPVGCLMWGVREEGIWSQRRKMAVVVGFLLNIGLGLIRYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6Z8</accession>
    <name>A0A1C1C6Z8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6Z8"/>
    <dbReference type="STRING" id="86049.A0A1C1C6Z8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00677"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01155"/>
    <dbReference type="eggNOG" id="ENOG502SN8F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5206740at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="334" mass="36775" checksum="DCAE3E2D804A1791" modified="2016-11-02" version="1">MAISATPPLPHLLYHHDSITTLSMLPPQNATRLEPLSPTKKPKLSLNTSDLAPTFHGTVSRQTGITTNATATPTTLNTFNNTFDLTYRPSPVSTLSSPGSHSQWKPSVHPSSPSTRLSNQPYNLSLPFGIRPILKNSPLCVDTHRASISASPRVPGRKVFFPAPKKVTFRAQLEDEIVTKRYVERHVDLSSSEDESAPSETEDRSNTSSDEEEVGKGRPTILVDEFSVQGRRKRKSVALSPSPATEIGRGREDTSRSTSTRRSKRKRRRWEWTIQSERVENSKPPLPVKESEDVEEDRVSTSLELPTSPALEETERSGAVHEAASPSLAGAQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7D5</accession>
    <name>A0A1C1C7D5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bcp1</name>
        <name evidence="5" type="ORF">CLCR_06170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the BCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7D5"/>
    <dbReference type="STRING" id="86049.A0A1C1C7D5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06170"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07109"/>
    <dbReference type="eggNOG" id="KOG3034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="289" mass="32382" checksum="22BD004205D4AC91" modified="2016-11-02" version="1">MSKRKQDGGDEVVKNDAPQDDESGDDEDFDVLDVDFEWFDPQPEFDFHGIKTLLQQLFDVDAQLFDLSALTDVILAQPTLGSTVKVDGNETDAYAFLSILNLQQHKDKPFVNKIAQYIHSKAKSNPNLAALAELLSQPTIPAIGLILTERLINVPAEVVPPMYTMLLEEMDWAVQDGEPYNFSHYLILSKTYTEVASKLDAEDEQPKKKKKSGSGSSEPMYFHPEDEVLHRYAICHGGFDYSIKQDDGHSDSKRAFQEMGIKPQGHATLIAADRFKDAVQNVADYLKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7H4</accession>
    <name>A0A1C1C7H4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YCII-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7H4"/>
    <dbReference type="STRING" id="86049.A0A1C1C7H4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06290"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07165"/>
    <dbReference type="eggNOG" id="ENOG502SVFN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3933054at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35174:SF4">
        <property type="entry name" value="BLL7163 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35174">
        <property type="entry name" value="BLL7171 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="2">
        <location>
            <begin position="11"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="143" mass="15719" checksum="D079CB619DA1B82C" modified="2016-11-02" version="1">MPKFIVLVHASKESEAGELPTTQELAEMNAFNKPAVEAGIILDADGFLASSTGARLTFNDKGSEPTVTHGPFALDNLIAGYWLVQLGSLDEVVEWAKKIPFNKGGKVEIRRVAGPEDFGDAMTSDIKEQEDEMRKIVEDRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7K0</accession>
    <name>A0A1C1C7K0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">nudA</name>
        <name evidence="17" type="ORF">CLCR_05332</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86049.A0A1C1C7K0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05332"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07195"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000004">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000829">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1926"/>
            <end position="2064"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2582"/>
            <end position="2732"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2924"/>
            <end position="3090"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="891"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3186"/>
            <end position="3241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3412"/>
            <end position="3453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT44514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="4341" mass="492884" checksum="AB19E60823B4B647" modified="2016-11-02" version="1">[encoded data, 4341 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7Y9</accession>
    <name>A0A1C1C7Y9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_06210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7Y9"/>
    <dbReference type="STRING" id="86049.A0A1C1C7Y9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06210"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07325"/>
    <dbReference type="eggNOG" id="KOG2889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="270" mass="31061" checksum="B2497E89FBE228D6" modified="2016-11-02" version="1">MSHRADASNTLDNRGYSGPLIRGQNPALLLETAMRDRITDSLYWKEQCFGLNAATLCDRAVELTYIGGTYGVAMKPTPFICLAFKLLTLVPDREIVLEYLKNGGEEWKYLRALAAFYVRLTFNPADVYKTLEPLLEDSRKLRQRRKEEYILIHMDEFVDNLLTKDRVCGTTLWKLPARQVLEDLDQLEERVSPLQAELDAMEEEENGDPDDLMEDVRPHTSASENGESPRSLRSSESRSRSRSRSRSQSRSRSRSRSRTRRRGSSRSYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8I9</accession>
    <name>A0A1C1C8I9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8I9"/>
    <dbReference type="STRING" id="86049.A0A1C1C8I9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06434"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07442"/>
    <dbReference type="OrthoDB" id="2110578at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT44768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="118" mass="12800" checksum="78A5F11CA4096393" modified="2016-11-02" version="1">MSFARVVGVLRPNDTTICDYYTPLILGKENTSANELELMALITHTFSRQLHHSYGIKVDGTVGPRTLQGHDINLLPYFTGGYVSSNDVGKASVVNFLDDGGATARLTNKPADTNNSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8X3</accession>
    <name>A0A1C1C8X3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8X3"/>
    <dbReference type="STRING" id="86049.A0A1C1C8X3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05911"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07657"/>
    <dbReference type="eggNOG" id="ENOG502QUTD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="54"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="407" mass="45441" checksum="95A96F595F79B650" modified="2016-11-02" version="1">MADHGSFTQLPSMVRKPKAVWPGLVKMGLHQRQIAGDDQLYGTPAKHPEIRASIIDHMRTFRPLFEHYVHIDDVQQRRTLRSTTLSTRQEPEDAFEEYLSRMSRLGSYGGEPELVAFCQVFDQDVTVHLPRIKNFNRDSIPYTNEHREGPNAMPPLHICYGGDEVTRAHYDSARSRDGSIPRHKNSPSLRPQDSTRNVHTSFSSPSPHGLVSDRAFRGSRAELSSEFIQDFLQKSKKDVDNNLDQLSEKYHARSPSVTSSQRSASSKRSLDDDEEPIRASKRADRRKSTRRRADMIVALSDADSELSPPVPIDSPAADTPPSTQDTDLSSEGPIQEHNEQPIKAKPTTLEDQDQCSDTGACLAHTQGGPQPRVTLKPVAERAPVVTTEPSGSRLMSVAERPKSTLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C910</accession>
    <name>A0A1C1C910_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="3 15">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">dot1</name>
        <name evidence="19" type="ORF">CLCR_05746</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="3 15"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C910"/>
    <dbReference type="STRING" id="86049.A0A1C1C910"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05746"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07598"/>
    <dbReference type="eggNOG" id="KOG3924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-79 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021162">
        <property type="entry name" value="Dot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017570">
        <property type="entry name" value="Histone_H3-K79_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 15 19" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 15 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="18">
        <location>
            <begin position="208"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="32"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="347"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="432"/>
            <end position="433"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR017570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017570-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCT44938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="546" mass="61275" checksum="B8D4D8E8BD7835AE" modified="2016-11-02" version="1">MGSLPTEGRPLSFSAMKARKAPLKIATKIVTVASTPKPVARSSPSAGPARPTSASQKSLSNGHSRTAIIPRKSSTPVSVRSRQGSVEPIERIKNARRNQNKRASPAVSTPRLTSSDEDTDDDDATQPRKRIRLEGTDSIDQNRKVRDVQAFSQEEDGGFHMVHAYDIANNSLVEHGHDQYAAFFTILNTHEEECPTIELQYPTSLQTERYQLVRPNDQSDFKPLDEIEANMRIVAEYYLDSASAEKVTSEEYGSGIVQQLRHQALLGFKGRPNAQGAQSKYVDLVNKFNALVAEKRKDGTIAQKLDQMRRVDLKLVEHIIKNQIYARTVSPRVNLVRQYEGFSDNVYGELLPKFLSQIFKETNLKSDQVFIDLGSGVGNCVLQAALETGCESWGCEVMKNCDTLAQLQAAEFPARCRLWGIKPGAIHLVHGDFLENKQIREVLKRADVILINNQAFTSELNDKLKYVFLDLKEGCQIVSLKPFRSPTHQIKAANVNDPINVLRVVEKERWSSMVSWTDDPGKWYHQHKDSRELQAFMEGLGGREKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C942</accession>
    <name>A0A1C1C942_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C942"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06485"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT44991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="85" mass="9683" checksum="32673622923A29B9" modified="2016-11-02" version="1">MPKRAKIWGATPEPLCRARMPENLKFIHWGGSEALVMFVGQGKNPRIDDHILLENSFHKVSGPKQGIDPGRWKRKVQDVGDYCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C972</accession>
    <name>A0A1C1C972_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C972"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06492"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07755"/>
    <dbReference type="OrthoDB" id="4158312at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="77" mass="9102" checksum="F67F64637C0777CB" modified="2016-11-02" version="1">MCRSRSRTLLLTAIFFIPLTSYLWLRRLESNSRERTRLLEEEGRRSWIQAEKEKQRYIAMRKDRDLSVAVGRSGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9K2</accession>
    <name>A0A1C1C9K2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9K2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06498"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="74" mass="7887" checksum="DCBB4A04CF28EEE6" modified="2016-11-02" version="1">MNGDGRQDEEAAKASAKRIRQTCAGGTRPGKDQSMWNSSTPSNELEKLEMICVGGSGGSTRFPDRRRKVAGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAR6</accession>
    <name>A0A1C1CAR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-specific adenosine-34 deaminase subunit Tad3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_01571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAR6"/>
    <dbReference type="STRING" id="86049.A0A1C1CAR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01571"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03478"/>
    <dbReference type="eggNOG" id="KOG2771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="191"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="434" mass="48304" checksum="7604C55B502D1200" modified="2016-11-02" version="1">MAEIEKVSACFLEPLKTVHETRSEEVFVRAFVVEIPAKLTSKALRYATQRVRAEAGLTQSVSIVKPIIPSGGKHPSFGHFRRVCTLSHLPEDLTWRRDYDARGLQTTFVLVPNTVVPWEDIKAIFEPHIDVEGLPRCFDAVVPRHAPLSAEQAALWSERYWPAIYNPAAQVIQDCPPLHHLRRTRALLEVPATDRYMELALTAAGQSKEHGHGRGVGAVVVDPETGAVVAVAGDARWWSADGELPQSLTADQGEGKPEWHAVMRVIAMVANKELRRRINAGGHLKFKDTCTETPSGQALTLIENHYEEEDEPLRDLSAGLGNIVLENCSIDALPEKRTGPRGEGYLCSGLDIYLTHEPCVCCAMAMIHSRFRACVFARRMYGSGGLSAEPGKNRLGYGLFWRRELNWRVMTFQHTLVAAQEGEDGRMDTEIFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB18</accession>
    <name>A0A1C1CB18_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_01712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB18"/>
    <dbReference type="STRING" id="86049.A0A1C1CB18"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01712"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03575"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650694" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="57"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT45676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="168" mass="17349" checksum="E05AF941E1AA9C28" modified="2016-11-02" version="1">MYLIWDHGASSLISIIVIFALVCVAQEGQVPLISSLPNAASAAYQSQQARYWASNQADFTPSCRISPTTGEEVGALVSQLAEFGDDVRFAISSGGHATASGASNVDDGITLDLSALDSVSLASDRSYVDVGTGTRWLDVYRALDPFALTATGGRAASVGVGGYLLGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB65</accession>
    <name>A0A1C1CB65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc-type alcohol dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_01570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB65"/>
    <dbReference type="STRING" id="86049.A0A1C1CB65"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01570"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03656"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08283">
        <property type="entry name" value="FDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="68"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT45764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="453" mass="49574" checksum="48DF16C7A54D80C0" modified="2016-11-02" version="1">MALSQAAGFVEKLIGHTGDANTEQNLSNPSKDAEKYADPSGEKMKALVWNGKNSVKVVETFKPAKIEDTDVIVKVTGSTVCGSDLHLYHGVVVELQKGDILGHEFCGVVDSVGSKISKIKPGDRVVCSFQIACGTCMYCQRKLSSQCEKTNDNKIENIMYGGRTAGMLGYSHFTGGYAGGQAEYVRVAYGDVNLLKLPEDVPDEKGLYLSDVLSTSWNAVVDTGVKEGDVVAIWGAGPIGQMAAAMSFMQGARRVIIIDGGAAAWRLDFVKSKLPKIETVNFTDLPRGKNIVSVLKEMEHGGPDVAIECVAGEYAKGWAHYFEILLGAETDTSEIVNEMIMSVKNFGRCGITGVYVGYTNHFNIGSLMERGIRLIGNGQAPVHLYWEDLLKKIQEGKLDVYQMVSHRVKLEELEEVYRRYDSREKGLQKVYVETKFSFPRAEGSPELTTYGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB85</accession>
    <name>A0A1C1CB85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Guanine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB85"/>
    <dbReference type="STRING" id="86049.A0A1C1CB85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01560"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03624"/>
    <dbReference type="eggNOG" id="KOG3968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006056">
        <property type="entry name" value="PRK08204.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF5">
        <property type="entry name" value="CHLOROHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="58"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="482" mass="53172" checksum="7D7C95FCA6B073D2" modified="2016-11-02" version="1">MVGKYHIQNGTVVSVDPSIGVVHNCDVLISDHTITDVGPNLSAKATPEHVVIDATNAIISPGFIDTHRHTWQTQLRTVTSDHVLSQYFLYIRSIYGSCYDVNDAYLGNYCGALESIDNGITFLIDHSHIMNSPEHADAAIKGLRDAKIRGVFCYGLYANPPWPGSVMNLDREMKTPEWRFEDAKRVRATHFKEKQDATDLLRFGFAPAEIERHGIDEAAKEVTFGRTLGAAVITGHIAMDQYDRGLHLVRHFEQRNLLGPDLLFSHGAGLHDDELEAVARRGVSLSSTPDTELQMGMGHPVAFRAQKKGCTASLGCDVVCNNPADMFQQMRLLLQTQRHLEHHELPGGGPPLNISRRCEEILEMATMGGARAVGLKDVVGSISPGKRADVLITRCDSTRLVPVLDPVAALVLYANASDIDTVLIDGEVVKQDGRLAGVDWPKVRDELRQSTRDIFERSKKAPFEQIKAEVDKFASHFAGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBY9</accession>
    <name>A0A1C1CBY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00530"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10038"/>
    <dbReference type="OrthoDB" id="4158609at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="103" mass="11059" checksum="CB97FB641F8A2628" modified="2016-11-02" version="1">MFLKQYNYKPRSNSQSSQGSGGSSGSPPPKEEPKTTESNNKAAGNAAAAGRRRRRQSSASDKFAGLTAMKRSSQDERKASWTEQKAGTGILGGMWQNFTKGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC41</accession>
    <name>A0A1C1CC41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC41"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01249"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09405"/>
    <dbReference type="OrthoDB" id="4160921at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="365" mass="41654" checksum="1121F9ECD3A04245" modified="2016-11-02" version="1">MKGAEWPLERPRGLRLFTLGKNAFYVLPQHSPWGGDNHYFYERAEHKRHPSFPAPVVPYGAEPPDNLPPSSHRLMNARSIPEEYWGDMEIFRPALTAPASYLVASPAAARLKSLPLEFGHFMGPLWYDGSQSGYYNRANLRPTPFVVLLHPVDKSFWVVFDHLPLSQKILTPGEQSKLRRWCDECADEQEWDDCPYFDYDYNKEAFWKPIHPEVSYVAPIERLEDVAFWEEVGMPPFSILRIPPFREGGRRNRAEDMGEDMGEARAQGLVGEEEEEEQSSHAGGGPFLEVGLGGVTMRVEATNVRPNPFKAKHQEFKDYWNKWVSEPAPGDPPESSSDQDGQEEEPEQPVAGGSRVRKCRICRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCM4</accession>
    <name>A0A1C1CCM4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Luc7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_01284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCM4"/>
    <dbReference type="STRING" id="86049.A0A1C1CCM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01284"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09249"/>
    <dbReference type="eggNOG" id="KOG0796">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="302" mass="33156" checksum="B37219DCBAFB20C3" modified="2016-11-02" version="1">MAAEQRKLLEQLMGDQFMGMGSSSKTANLTLTSPTVCRSYLVGTCPHDLFTNTKQDLGPCPKAHPENLKMEYDGLSQAEKQKYGFEYDYMRDMQKYIDECNRRIDQAQRRLEKTPDEIRQTNNLLKLISDLTKTINTGLLEVSCLAEMGSVSLACTEFHKVRTAKLAKEQAERDLKSLSDTSGPSGHQKLQVCDVCGAYLSRLDNDRRLADHFYGKMHLGYAQMRRTFDTLAKDLKGRGPPPVRADDGMGPGQGSPTGPRGYDDGYGDGGGWGRGGGGYGRGGGGYGRGGGGYGRGRGRGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCN4</accession>
    <name>A0A1C1CCN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCN4"/>
    <dbReference type="STRING" id="86049.A0A1C1CCN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01175"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09239"/>
    <dbReference type="OrthoDB" id="2402960at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="515" mass="53581" checksum="EC429CE144CE79EE" modified="2016-11-02" version="1">MEDFSQSRGDDDLFDDEIIPIENHPSPDTVATQLDQVSLEPALVPPPIEAVAAAVPAPQVANPPAVTSFANDAPSSGYRQKPRGRGVGQQAGRAGGGGGGPRKPPPTTTAAASAGLEGSKWATPTTTTTTTADSDRSTTRAAAAAVASKAGKVTLRPQEPAQPEMTATTTNTEPTTRPQQSAAADEAVAAQQPPLLLPPNNTKTPAVRGDRTLTGGLARPKLTEEELSAKLAAAKERSQTVAAAHARAQADAASFQERERMATEKRAVERKERRVMEGEREKNRLRKLGNREGREWDRDKEDVTTMMNNDAEGLNARGGRGGRRGGSGRGRGGGGGYTEYGGGGRAFMAGQSEDNHDDDVDLRQYEWRDDDRSRTRGRGRGGGRGRGRGGGARDRGGGGSGPSWDQQQQPNTSAEAEFPALPSGSGSGSGSGSGSGSASKPPQPQPQPQKQHTGTSTSTSTNTSTNTSTSTNMDTDTKSSAKDTHKPSPRRWDSAGGGGGGGTWADQVESSELNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCN5</accession>
    <name>A0A1C1CCN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase reductase 2a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SDR2a</name>
        <name evidence="4" type="ORF">CLCR_01290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCN5"/>
    <dbReference type="STRING" id="86049.A0A1C1CCN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01290"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09283"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="284" mass="29711" checksum="247F4CDBA8CE3F1A" modified="2016-11-02" version="1">MVDYVFPKPPRSLANKVAIITGAGAHGDGIGNARASAILLADEGCTVVCVDRALALAERTVEMIRAEGKADAIALEADVTVEADCKRIVDTTVARFGRLDILFNCVGIGGASGTALDVDMAAWAASMTVNVASMVMMAKYAIPEMVKNDDEWGYRGAVINMGSVAGIKGGTPHLLYPTSKGAVVNMTRAMAVHHAPQGIRVNCVCPGMVYTPMMYAAGMSEEAREARKNRSLLKTEGNGWDVGCAVRFLAGPESRWITGLILPVDAGATAAVGTDIPRSASVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCV1</accession>
    <name>A0A1C1CCV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Siderophore iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_01135</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01135"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09232"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4088837at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT46292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="601" mass="65529" checksum="463071D1C3B2DD16" modified="2016-11-02" version="1">MAAHGFRNSMSEDSHSKAHDFTSEPKIADHGSPDYAPERPSERRQSIVEAEKSPGVVRIEAINEVLTRKDRLFLFIGVFLIAYAYGLDGTIRYTYQATATASMGHHSLLATVTTLRAVIAAAAQPTAAKIADVFGRLELVFVSVVFYVLGTIIEASANNINAFLGGAVLYQIGYTCVILLVEVIVADITSLRARLFFSYIPATPFIINTWISGNVTAAVLGTTTWKWGIGMWCIIYPVCSLPLMLALWFSGRRARKAGVLEKYKTPYQMWGARRLSVELFWALDIPGIILLIAVFALILVPLTIAGGNTSSWNRAHVIAPLVIGILCVPAFVFWEMRAPRPLVPFHLLRDRGVWGALGIACCLNFAWYMQGDYLYTVLIVAFDFSIMGATRISSLYSFCSVVSGFLLGMVVYKVRRLKWFIVAGTCLFLVAFGLLIHYRGSTTSSSQAGVIGAQVLLGIAGGMFPYPAQASIQAATKHEHVAVITGLYLATYNIGSALGGAISGTIWTNVLPQRLEENLALFGNATLASSTYADPFTMASLYPAGTPVRTAIIESYQHAQRLLCITGICICTLLIGFAMCLRNPRLGDEQSLPDAEENVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCX1</accession>
    <name>A0A1C1CCX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01120"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09151"/>
    <dbReference type="eggNOG" id="ENOG502STC2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3523207at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650718" evidence="1">
        <location>
            <begin position="20"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="633" mass="68811" checksum="3B081E6CF094D1A3" modified="2016-11-02" version="1">MCRFYLGFILCAFSSLVLSSPAPRAATTNCYPLIAGSQQAHFPSANLPCVAVPENSVTQGNLKVSTYHWVKGPDTAVVYGEKAQLHSKSINDGIQKAVKAYGGFLKEAPLSTNLVFIPAASLPDGWGDTWMQKGTTVAQRKFSVLIANFRDGFQPDYNKWARTTAHELYHCVLMSTNAQDAQAAHPWNQWWDEGGPSFFASALFPEPLDPTLKIYSDPDHPDLNIQGWFQTYKPTESLYNQGYSAELFFLDMYTRPTQSRQDLANIHSFLSQQDMSSTEQAERARVAGDGFTPDQFREFAQRFADGVIKLRRDADVKAAVFPVYKQGYQESKTVKLGANAAPATWTASKLVSFGFMRLDLSLQAPDTKNQVTYAISAASQGAGTTIFYRAKTAKKWTKLDAGTSKKVTVGCGSGPQDYVLLFVSTDGTDPPKPVLSVARQSSKKCPCTSARRSLLSLRQESCESEGACLDGTWKLDLDSLKAAIQAALAKSSADATVTNLKLGGSSTFVYDEAASTASMSFDHTTISYDGSASGYEVHIDIDINGKAQGPVAMTGDDSFHWTDITGSGEYNTATILKGLGDDTPIEVDMPLTAVYTADVVVKYTCSGDKLTLEGLENGLYVWTYSYTRSGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD34</accession>
    <name>A0A1C1CD34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Life-span regulatory factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD34"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01253"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09153"/>
    <dbReference type="eggNOG" id="ENOG502S77Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3599883at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="33609" checksum="E48B556BAF8CFA13" modified="2016-11-02" version="1">MDSPTAKISHGKYSSPRKLKRRSGEGDSVSAPRAFAPVDKKKQPQDMAASFLQFCAMCEKQIMTPCNSILYCSEACRRKDAAKPLSASTLSLDSSSPSAALDSSPRPPTLLHHSSARPEYQAAPPSSSSSSSSSPSRIPIDIHDHKSDLDPTEWKPKLPHRGASTSSEAFRYLSRFHQAQVGNVDHLDQGKRDRPPATLRHKSTLSMSTLTPGTTTPSLANTPTTTASSVDSLYEFNLRPLAPRTNPLYSTSAGHSRGIDLVTPHIPPPAVPVHVVMVAGSAGTQAGNDLWDKKVVVPGATPKGEGLGVLFGRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDN5</accession>
    <name>A0A1C1CDN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha,alpha-trehalose-phosphate synthase (UDP-forming)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDN5"/>
    <dbReference type="STRING" id="86049.A0A1C1CDN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02007"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01306"/>
    <dbReference type="eggNOG" id="ENOG502S4UX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="26"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="172"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="355" mass="39873" checksum="E6D502C775C9FD00" modified="2016-11-02" version="1">MVLPTFADVLPIKQLSSHQYALTLENEWCIGTVPNGGYVTSAFLVVARMHMSLTHRARSSPHPINLHLEFLRRTSVGPAVFTVKDVKLGSRISNLHITLSQKQDASNDEGPYQDEAQGYITMSNVATEEGLSLDTQYHLYPPALPVNLSLLASQGQDENYTHRAAEPFPSFRRAAQNIQIFLVRPERKPAPDRSTGRPRAMVEQWVRFTPKTQRFDGAVGRWTNDALGFLVDMFPQVVESYVNPFVEEAAIGQHSQSDLKQFLTSNEPRAKYWYPTLALNLDVKKLLPDEGVEWLFVRVKAKVIKNGRFDLDIEVWDEQGELVASSVHASLVMDASRNISRKNGSGNGKKKDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDV0</accession>
    <name>A0A1C1CDV0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02074"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01352"/>
    <dbReference type="OrthoDB" id="4145730at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="272" mass="30000" checksum="3DF7A1BB68FB3A4E" modified="2016-11-02" version="1">MSSGANFEFVLVTQRGQTTKERQLQQAFARSHAAKVSHSSRQRPKASPKKAQQCVAREPCLAPIIKPDPDLSVAALSSPRSIIGDAWSDPFDGGGPRQIPSVGRKSLEYVYTVLWPKNYPAVSGLTLKSMQTTWRRRAIEDPLQFHAQVFNATTMCYALSTEPSTMLTLMDIRLKHQTAAVKLVRKRLQTMKGPAPEQLIADIMRLAAQGGDTFRLSTSSQYPETPLANAFALKPYGRFDTSLPHFSALIQLVKQRGGLETLSVSVGHPIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDZ6</accession>
    <name>A0A1C1CDZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">srs2</name>
        <name evidence="15" type="ORF">CLCR_01810</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDZ6"/>
    <dbReference type="STRING" id="86049.A0A1C1CDZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01810"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01470"/>
    <dbReference type="eggNOG" id="KOG2108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18807">
        <property type="entry name" value="SF1_C_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="13">
        <location>
            <begin position="5"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="14">
        <location>
            <begin position="280"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="691"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="826"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="911"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1002"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="964"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT46755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1028" mass="113839" checksum="5269BDDD58FB53EB" modified="2016-11-02" version="1">MQLLAGLNAAQRAAVTSPASVLQVLAPPGSGKTKTLTCRVAYLLSHQGHNPQNVICCTFTIKAAREMRERLRGLVGDHLESKLVLGTIHSICRRYLVAYGHLIRIPKGFGIADTSDSNSIIKRICKRMNLSIEPKVARARISSHKAKGKALEDLPKSQPKELKEQEFVTVFHEYEAALATSKLLDYDDLLLRCVDLLRAYPACVSNVEALLIDEFQDTNIVQFELMKLLASRNRRITIVGDPDQSIYGFRAAEIENLSRMKTFYPETVVINLEENYRSTSAVLALAQDVIEQDESRPQKRMKATHCHGTRPVLRRLPNPNEEALWIASEIKRTMAMTGGLLLHSDFAILLRSAYLSLLIERALTNAGIPYRMVGGQRFFDRVEIRVIIDYLRTISHPENNQAFLAIINIPSRKIGETSIAEMVKLGEENKLSLWTVAQKVLVGELKPAKKLSKPAEQELGRLLNLIKTGRQKMNTVSPATSVPSKLIDFLVNTLDYENYLKKKYKDDHEDRIENVKELVTHASEVLLQSAAEEPLASIEGLEQEASNGGQEVLAQFLANIVLSTDVENEEGNDKPRVTISTIHSAKGLEWPVVFIPAIYEGSIPHSRAENTDEERRLLYVAMTRAQALLTMTFPMLQSRDQGESILTQFLPSELHHRTCRTGPLFDDRVIRDLASILKRPVPSQEDLAKSLQTLDGDDSREDDAWPPDGSRRPTPMLAGDGHALPEFGRPLGEVLAAQKQQYRSYSTMAAPNRVVGSRSPEIATTMSRAGSFSTSNMSLGFTTAGYQLKNVWERAPASSDPTPPLKKPKLSKSASVQGNIAGFFSQPAMQARRPPPEPAPAPTARDLYPQRKQDQGATQVKQVWQSFESYSFGSSIPQELSSHKLNANNGFRYRPSAPLRDANASSTIRYAGLYSSSPPPVDDEDKKPHLRLTGDENEGISKGSGFKPSLPPSRADLETDSRLNNINNTNNTNGGTCTKPATTMHKTSMASVSTGFSSAAMLGSNPGVGRKTLGVRRTMNGWNDRRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CED4</accession>
    <name>A0A1C1CED4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CLCR_01974</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CED4"/>
    <dbReference type="STRING" id="86049.A0A1C1CED4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01974"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01530"/>
    <dbReference type="eggNOG" id="ENOG502QQJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="ARHD_Rieske_2Fe_2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="14">
        <location>
            <begin position="51"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT46816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="416" mass="47683" checksum="889EAD1B10154CC9" modified="2016-11-02" version="1">MLPFLGYLGLGGSSASNKNESASSVRALPASWYTSDEMYELERRAIFSRKWMMVTHQLRLKQPGDYLRYDVAGFQFVLCKDREGKINGFHNVCRHRAFPVVTQNSGQAKIFSCLYHGWSYGLNGKLAKAPGYQDLPDFDKTKNSLFPIHVHIDGNGFIWVNLDAKSEPEIPWSDEFQGIEDLPRYDGVNWDDFEYDHTWEMEGAYNWKIAADNYNECYHCKTVHPDIPAIADLTSYSVDTEAGTILHNPATKPEQAAAGMTVAPTYFFPNNSMTITPHFFYTQRFVPISPSKTLMQYEVYRNTKSAIEDFKNIDAIYKRVMKEDKYLCDLTQRNLRAGVFVNGEMHPKMEKGPLYFQQRCREIVQEHWKKETAEKREIWPARQRLPGDGSAMVTGKDLDFCSGLACDSGNKAQLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEJ6</accession>
    <name>A0A1C1CEJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02668"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02517"/>
    <dbReference type="eggNOG" id="ENOG502SA6U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16060" checksum="5F433BAC3C2777DE" modified="2016-11-02" version="1">MSSNNNPWSNTESSGNPYTSPTSQQNQGAAQGYYQSNPSQYQSQPQSHGHQQPQPQSHNTAPSHGIHRSDTEQLLAQQGDRAAQVEHMQQYEANAPQSEDDRIQAQLQKEFPNIDSSLIAAIYGERKGQGDLGEVRELLQELNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEV9</accession>
    <name>A0A1C1CEV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEV9"/>
    <dbReference type="STRING" id="86049.A0A1C1CEV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02326"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02368"/>
    <dbReference type="eggNOG" id="ENOG502SJN2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5407894at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="609" mass="67271" checksum="AEFF7C96F2640065" modified="2016-11-02" version="1">MTTQPLSLDDGLPAISKRLPVVQVQELPLCTPIREQGDEITYGVVEVVGKSVDGLDESSKIMLMGMGLKRPYSGGEHDGHRISRPEIRRRSSSIGSPEGVKMDHQDHDSQEQLFVRLHKTRSVDAAKSFEVKIEKDKQRASRRDLVRDCPLPSEQAALPSLLGPLPPRGWYHPSQFLGQALNGPGGIVAPLTPPDDLDSFKWESPSHTQSAEAVRTVPNVEQSRRQGQGQHNQTRTSSTSRPSEIQMPEPSDMAGGDSSRPNWLGRACQKLVSCLGNSSTQQQVQMVAQALPARPNSADMRQVMDKVVEDIQSQFTIPPYITITHAYFQAISMDEVPASPPATPNAQSSSSDDYFQDHTIFTHAATVPAYHFHSGAVHPGGPRPSNIIAAPSSIQISILERYIPPTTAREVEDFFTLSRRSYLADRLLELSSDDGSLLLIYPTKRGGQAFANRYIGPVIEPFLRQFILLNSLYTEIAMKLGRMAAVSGMKSFDEMTALLAAMCEALTQRAPARGLPSRYNIVHAETAEVVLDRSLWRDWYIEQEKPRLRQDLVDYHKSGGRMPSRSGQIEITPGMLAREVLDGIRQSREAAGDVGLEVGVFVIRRSTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF62</accession>
    <name>A0A1C1CF62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sfi1 spindle body domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_02351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF62"/>
    <dbReference type="STRING" id="86049.A0A1C1CF62"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02351"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02291"/>
    <dbReference type="eggNOG" id="KOG4775">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5215300at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="3">
        <location>
            <begin position="274"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="597" mass="68443" checksum="C632C6D291FF6588" modified="2016-11-02" version="1">MTPEELARFASTVGAFSAAQIDRLYQLVVSVWGGAGASALSEQWRALGLQEGNNSVAEGVDDGVCLDFIVDLAKIDPDTPLDAKFFAILEAANIALTTTTTSSPRPSSPHSVESIDENEPLWRQAVALDNRRLVSQVIDIWQDRVIERRAAYEQYEDAEANAVADTQYRDKLAKRTIDRWRSRVQHVKSLEAMAARLRFERDASRVLRALTLAERETVFVRERTRRSAARFLAIWREKTARIHELEDYADSFRKIHAAQNVLARLSETHHHHQEAESLAVTIYEGNLVRRIFNQWLAQSQAIRVNDERAEAAADYFAAKHAFQKLRARAQSRLVQNEVAQARAHILYLKYFRKWRLAVRDIKEAKYNAAYKTMRRKVKENIARASLNLWREKTRRIREMHATADEFRAQKQGENARKKAHSAIVAMYRHTEETQRAEKLADEFYHQTLVRRLGIFGSNWLVPARQILANQRLADEYRATRLATYTLGALRTMRNYAFRAKRLEEDADTLRQRNEKKRALAFLQRWRQAAMRAHEDGAAVENSLVPATPAARRSQLLASTTPAYTPATGLFSAASRMIAEDHDEEEEGEDQEESMRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFA6</accession>
    <name>A0A1C1CFA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Mitochondrial chaperone BCS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">BCS1</name>
        <name evidence="16" type="ORF">CLCR_02397</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFA6"/>
    <dbReference type="STRING" id="86049.A0A1C1CFA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02397"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02222"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="81"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="303"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT47210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="526" mass="58303" checksum="BA27610BF4E1DDC7" modified="2016-11-02" version="1">MQSDNGVVKVPANPASVPPELNDGGGAAHKADLIRQFASSGNSGDGGLIAQLSNNPFFTAVGLLRQLARSRLKVYQGFGLAGLTAIAAFGRRGIRHGAALMRRRLLVDVEISVRDDSYPWFLYWMTLHERGRVVGHAAQGKVSRFESLLQRLTPGMRHLAIETEKRELPNGAIHTNFVLIPGPGRHVIRYNGAWIFVNRQREGKQFSMDGKPWETVTLTTLYSQRHVFESLFKEAHDIATQSVEGKTVIYTAWGTKWDKFGNPRSKRPLESVILDKGVKERIVSDVQDFLSSAKWYYERGIPYRRGYLLYGPPGTGKSSFIQALAGHLNYDIAMLNLSERGLTDDRLNHLLTVIPQRTLVLLEDVDAAFANRRQVEADGYQGANVTFSGLLNALDGVGSAEERIIFLTTNHVDRLDEALVRPGRVDMTVRLGEATTYQIEQLWARFYSEQDPEGLFKARFVGRLHEIGVLSEPSAVSSRTSMAALQGLFLYNKGSPQGAIDMAWQLAPGGLPSALTKESRQQANTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG16</accession>
    <name>A0A1C1CG16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein gpi1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gpi1</name>
        <name evidence="3" type="ORF">CLCR_03324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG16"/>
    <dbReference type="STRING" id="86049.A0A1C1CG16"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03324"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01909"/>
    <dbReference type="eggNOG" id="KOG1183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="749" mass="85040" checksum="E9C96A015C1FFD1C" modified="2016-11-02" version="1">MVENSDGMLRVFWPNNLTRTTSPGVIVGWRNSSFDLFVITVLEDVEVRSVESALRVGTLFRNSPYPVARIFQLCDQPNMHVLGTLNHPSPTEVFDPKRVCAYTVSGSRRPYIYCPPDAGLAVQIVLFDPPNPTQMQYMSLEPISLALGKDYWPPSETDYMPDEVEVQEEKERQRTAELVAKLRFHTVVRHTPTKKELALPAIVRQINCAQEVADLLQKNTPLVGPRRKRSLSVSERVVESAQSLYAFAAWSLWTLFMAYAFPFLLYIFKIAIIGHRIVAEGLLQILEWPLPIKKIRLPESRRPVRGAVALKDISACCQQVHLRLQQFSYYPTQYSLLRRRKATWSSFPTTNSDYIRFYNSLWLVANDVIIGIALGSFISDNSQATSQLIGGVLNEYTIKGLKRMIRWLMSYPGGLKLNTELAAFLGDLFLWVIEYWASTIFLLILPRLPTIVYVIGCSSFAGASMPIAIFSDLLSLLTIHIYSFYVASARIFNWQLTIIVSLFHLFRGKKRNVLRNRIDNCDYDLDQLLLGTILFTLLFFLLPTVVVFYLTFASARMAIITLKATLDTCLACLNHFPLFALMLRIKDSQRLPGGIHFQLLDTEQSKVPNSDETGHQESQDDTADDDSDEEGEGEDFATSVAYIRLTSTPLALRQIFEQYFQLWARIHQHYLSPKVVFRLLTGRFVPPLGRSEMYGLQYSVLPRERATVAEVWKSLNETEPVAASDGMANIRGPKSYLGAHGSAIGKQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG86</accession>
    <name>A0A1C1CG86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG86"/>
    <dbReference type="STRING" id="86049.A0A1C1CG86"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03650"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01907"/>
    <dbReference type="OrthoDB" id="4161669at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650794" evidence="2">
        <location>
            <begin position="21"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="226" mass="22590" checksum="56AC4AFA5C71147A" modified="2016-11-02" version="1">MKITKLFGVAVAAYAAMTIATPPNLAARDEAIGSLAARGFSHEEITDLMNLLPRQDAAATVTVYPTTCAPYGVPPVSEPAPPPPASTASQVTITSSFTMTSTVITPSTTPITPTTSLEPPSAPVVPPPTTPNVETPAVPPASTPVETSVSVTPVPTTPSPVTDSSSVVRTTTSSALTHTSISTATSTHTTMTASTSTGIPPAPSNGANSAAVNLGVLGVFAVLAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGU5</accession>
    <name>A0A1C1CGU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="10">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_03398</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the trans-sulfuration enzymes family. MET7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="10"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGU5"/>
    <dbReference type="STRING" id="86049.A0A1C1CGU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03398"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04639"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000111">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="163"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT47702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="603" mass="66965" checksum="5E2673E89DB33E28" modified="2016-11-02" version="1">MLAAVGQPVPNTPHAVSVSLPSWKATVGYEEGEDWVLSKMQTGYPRFFIHLTIQELGTEILKLYGRSGEAVMLFPSLATAKRCLKFFYDKVEGLGVGVVHVLQLEPVNAGNRSHATTLSSLSCVFFPKEYFSVAKQVWQHTGDGISSRRGEFCLKALRDGILEPVTTQPQPRPDDMYTKGPRRYQRPGSRNGIIHDIPSSNNATTDRAGTDGEDRDHAQFVEERFGRNLNVKLASQAKLAIRRRISGCLTDDAELEQALTNSPDACAGRQKGLSENDVYLYPSGMSSIFNTHRILLANAEANGQPPRKSICFGFPYIDTLKILEKWGPGCLFYGHGSAACIDDLERRLDAGERFLALFTEFPSNPLLNSADLQRIRVLADKYDFTVVVDETVGNFTNIDVLSRADIVVSSLTKVFSGDSNVMGGSCVLNPQSKWYPELKQAMSREYEDNYWAEDAVFMERNSRDFIRRSERINQNAEAVVTLLQQCPLVKQVYYPKCSPSRPNYDACRSPNGGYGGLLSVTFQHPGQAVAFFDALEVEKGPSLGTNFTLACPYTVLAHYAEMEWTAQWGVEPDLVRLSVGLEEPAELAGKVDRALKAAERVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI48</accession>
    <name>A0A1C1CI48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spo7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI48"/>
    <dbReference type="STRING" id="86049.A0A1C1CI48"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04017"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08327"/>
    <dbReference type="eggNOG" id="ENOG502QTI4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249:SF1">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="572" mass="64226" checksum="55E032B30299AA3E" modified="2016-11-02" version="1">MSKRDFAGLTFLHGPTVIHAEEAFANNDTSSLSLALSAAATMTSPSPELRLNQIVKGAPTTNIAASPIPPPLQSLGKQSSEAQQSSLDPHLSTLPSSPPQIYLNLLILESSLRAQYLHLVSRRRLNTFFLLLLAAWNGLFFYALFLRPREDGTGLGGSVYWVIETGEKLALMGGVVTVLLVWGTGQWERGIRWPRKWLGTTNRGLRTFNLRVVITKKRFVREMLGHLSFLLPFGLWREAGGSDWHLVEHETGIIVEEDLAKGGDGIMLLLLPKSFSPEFRENWEEYRTEYWDKENERRAGLRRKLHAQRRSKAKETGGWKWWTGAWRLQSTRHPHQRKHQDLEKHPHGHHLHGSSHRASLSEKHNHTHSRSRQSSRSSTPHLEFDGTTERPLSERMRRGSSVSSTASARRKTTRDRKDGTPTGSPLLSPLTSTSLSMSMSGGAEDEREERRRRRKEREAAKKEREREKEKAEAEAESQARQGESNHHQHELQRQQQHKGKGTSKGKGKSKLKDELEGTDETETNQATTAAGYDAGESSVPTTPMNNGHDGEAFSLDIAAPAAYEDGTIKAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIC5</accession>
    <name>A0A1C1CIC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_04158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIC5"/>
    <dbReference type="STRING" id="86049.A0A1C1CIC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04158"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08405"/>
    <dbReference type="eggNOG" id="KOG2117">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446635at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053246">
        <property type="entry name" value="NS_splicing_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845:SF1">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="4">
        <location>
            <begin position="105"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT48258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="409" mass="46580" checksum="2DB333CA772F1BEC" modified="2016-11-02" version="1">MPALAFGLNAARSGPSKPAQKRKAFFDQDDDAPEDVPPPAYGAKKSSKPLRPLTDLGDDEDEEQPPRKSPKLSSYGLQPAKGKSPGPTLGSDKYTNLSALRSARLHDEEASKLDASVYDYDAVYDTFHAHKEKSSNSGAQDSGPKYMGSLLQSAEVRKRDQLRAREKLLQREREAEGDEFADKEKFVTGAYKKQQEEIRKMEEEEKKREEAEEERRRKGGGMTAFHKRMLEKDEERMQMIKEAEEQAAERKGRGVEVEQEADEETSDAKIAEDLNKRGARVVVNDEGEVVDKRQLLSAGLNVAPKKPGQEQQATTKQEGARPQEYWRSSKAHDAREAQRERQSRMMERQIEEMLEKQKHAEAEENKAQQEKNKSRVTEADKMSARERYLQRKKEREEEARKKREAGTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIJ9</accession>
    <name>A0A1C1CIJ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_03905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIJ9"/>
    <dbReference type="STRING" id="86049.A0A1C1CIJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03905"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08493"/>
    <dbReference type="eggNOG" id="KOG1770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="284718at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000005">
        <property type="entry name" value="Sui1 translation initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="166"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="348" mass="39101" checksum="DDEAD8723112AA8F" modified="2016-11-02" version="1">MASKKDMRRADLIIPYTEPKDEKASDFSSTITSTMPMAAMFTRNRMLGWFSLMTALLNWLGETPAQRSSPSGTPGYLSFGMALLAVGVTYMPLFLPPPPNARGPAAAPPAASTYYRFIPQRQFTFQLQAIPGTDEFMSTIQNLKTFDPFAEADDDTGEAKQSQNYIHIRIQQRNGRKTLTTVQGLPKKFDQKKILKVIKKKFACNGTIVTDSEMGEVIQLQGDQRKDVQEFLVAKDGLELDAKTIKIEVVARRESPSLYDYFWPVRLRWSMQRPNYDSIFGIRYGYAFMIPTIEVYFLKGTGGDGVGHWDYGGRGSRSSRTLAASSFDVRGTDWFLSLMLPVPVTSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIK8</accession>
    <name>A0A1C1CIK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_03860</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIK8"/>
    <dbReference type="STRING" id="86049.A0A1C1CIK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03860"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08490"/>
    <dbReference type="eggNOG" id="KOG4293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF24">
        <property type="entry name" value="DOMON RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="54"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="357"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="502"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="601"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="643"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="763"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="698"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="776"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="842"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT48349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="861" mass="92254" checksum="9281E07BB0312DC6" modified="2016-11-02" version="1">MSPSPQLAPPGSSTYNSDTMHVGDGTWDAGRDNFLLPPLVGLNFATMRYNGKKSTDLSEEPQQTDTRTGMGNRFFTLAGYHGLVEAHGIIAAITFLGIVPLAIFLMRFYGRNPRLALRLHIWLQILTLLLTTVVIILGFQAVGPNRSLTNPHHGIGVAIYVLVWVQIIGGCMLHRREKGRRRLHIPLTAMLHHWLGRGIALLGITQVALGLTLYGSPQFLFVLYSLWGFFLLVLYFILQWMSERRRARYGNDGGSYYSDEVVEGRADHGHIGIGKLAVAGAAGAGLAALWRRRSSRRNPSPGRSQADGTGTEVTGSGSSYFDEKMSDRSHHGIGHRLLQVAAVGGAIAAVKKIFDRRTRDDESDVGPYRPPLGGNQSVTSDSMSRIEEGRPPPVRPVTPGAGGSPGYGRPTHPLAQPPMTPGSAYRRHSGSSSSYDSFVSGSPSRRDRRSHTFRDAVAAGGAVFAVRQLFKNRRQRKEELRAEQLRRERIEQEKVARMNSRHRYTGDGVTPPRRARHGRMGSQTASDLSTDLSPPGPGMSGAIPAAAGAGVGAAAASALASRHQIRPVGQDPPIVQPGQPYGAAPIPGALPVPGTLPVAEGVPPIPPPHLESSGSELYTTGSGRQRHRHHLQDEAAAGLAGAALGAAAADGSRRRRHSSRNNNTDSMESPPVSVKINMHNEGGRVTLRRLTEEEAASQRRKQRQASAAARRHRRGSSVSASDSEAGPSSADRRWRRTEALEAEQAAQNEAAAQQHAAAQYGAVQAAQAPVPPPAVSYPTAPEPTNIPTGTLHTYPGPLPPPPPIPGSASNLGYPAGSGVTSPGTETSGATEYANNRRRRRAERAQARLAKEGRTGASVEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIQ8</accession>
    <name>A0A1C1CIQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_04166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIQ8"/>
    <dbReference type="STRING" id="86049.A0A1C1CIQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04166"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08521"/>
    <dbReference type="eggNOG" id="ENOG502STQI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="356"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="208"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="401" mass="43496" checksum="7F776D60A65D5E8A" modified="2016-11-02" version="1">MAVEPQEGIFSMTPPPSEFDEFDKSALLTCSPSLPGLCYPSPAPSSRGHNPSVSSESIYMLPSMSVSEHQGHDLQSISFDDASSDSVSFFPVPTVADTALTTHFNTTATSPAPTTADSYAMYEQNQWFPYSNYRQPTPLLPYDSISASSAHYPVFSHHPSAHIIPPTPQDVHTSHFDFSHVPTSTIPSHHHLAASPSFSQVSHPGTQSHRGSISSMSRSCSPSSTLSRGDTLRPSLRSNSTSSSTSLHAYGIPVVETPSTLLSTSVSASPSGHGGQTQSWRCAYPGCTSRATFTRGCDLRKHYNRHSKHLFCRVDGCPQSEAAAAARAKSADQPLAGGFSSKKDRARHEAKHNPGIKCEWRGPEGEECGRVFSRMDNMKDHVRRIHNKGQQQSNNALTSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ07</accession>
    <name>A0A1C1CJ07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ07"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04405"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="114" mass="12738" checksum="F22C963D89267EA8" modified="2016-11-02" version="1">MAECGHVPSPAYWWIAEPGSSHGLFACAQMLQRGNWGKVYDEVQRMLGAILEGIFRDSQSRRLEEIWCRVADGSSLGESKTCKSETCVPQLWSCPICIDEIEDRGVQQSSSELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJH8</accession>
    <name>A0A1C1CJH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_05093</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJH8"/>
    <dbReference type="STRING" id="86049.A0A1C1CJH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05093"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03226"/>
    <dbReference type="eggNOG" id="ENOG502S2C7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="181"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT48669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="232" mass="25769" checksum="41AF280D67EBAA89" modified="2016-11-02" version="1">MASPPQKVSLDSSNDLKNATDDALAPYLTSLPKPYTFKQDHFTTNIRLALGYTAVLIAGALFYADWKLGWDATKAYTGPACVSYFVLNGILTYWIWAVEAGTVFSGVREGGQRLTLRSSTQKYVPEYKLKVTYSAPSTGKNWEDKEITGKFTQWFNTHGYLQHKEFQQWLNSNIDVLKTAQAERSNKEKSSERVPVLMPATKAEEISTSATGLETASPVPASAKKSRPKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJU3</accession>
    <name>A0A1C1CJU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">los1</name>
        <name evidence="18" type="ORF">CLCR_04509</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
        <text evidence="14">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJU3"/>
    <dbReference type="STRING" id="86049.A0A1C1CJU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04509"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03111"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03112"/>
    <dbReference type="eggNOG" id="KOG2021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000355">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="9 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 14" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 14" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="16">
        <location>
            <begin position="106"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="17">
        <location>
            <begin position="344"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1058"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1065"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1106"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT48795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1118" mass="124765" checksum="8CB8C0B9B1C14C86" modified="2016-11-02" version="1">MDEQIISAIEIAYDPTADPALKRQAFEYVNQLRQEPSAWQPCLAISLQVPRQAMVIRVFCLEIVNNAVQGGLVDQAGLKTIKDQLVAYLQKFYGTAGQTDTPDPGTIVNKFAQTVTYLFSAFYGSGWETYFDDLLALTSAGTGTKDNYPGLIFYLTVLNSIHDEIGDQLVSRSRAEQDRANTLKDLIRARDVEKIARSWQDILSHWRTSSDVVAELCLKAIAKWVSWVDISFVVNQSMLELLFQQLERAQKVDPRESEEQARDAAIDVFTETVAKKMPAADKVNMITFLNLETVVSQLVTCPPLRDSRASNYDVDLAETVAKLVNTTVVDIVRILENENQSSPTWGKAEQLLASFLPHLLRFFSDLFDEVCSTVLNAMNDVLAFLRRASQGDAASSQRAAMLLPIIKAIFVKMRYDNTSDWNQEDEQTDEAEFQDLRKRLAALQSAIAAADEQLYIEAISGLVHDTFERLRSEGSQLNWRDLDLALHEVYLMGDLAVRAGGLYNKNKPNSPAAEKLVRMMLEMVQSNTGSFGHPAIQLQYMEICVRYSSFFEKHTEYIEPVLKNFLDLSHHPSLKVKARAWYLIHRLIRQLRANVGNAAEAVVQSLQDLLVIKAELPADQDADDMSSDGEAGADSTFTSQLYLFEAVGCICGATSVTAEKQVQYVRAIMQPIFADIERNLESARTGSELAGLQVHHGIMALGTIARGFSEFNPGVTNPGGGTEPSSQAKQAFAQVAEVTLVSLTALKSSFQIRTAARFAFSRLIGMVGARMMQQLPQWVDGLLTDSSTRDEMALFLRLLDQVIFGFKNDIFDFLDRLFSGLLQRVFAGISAPTSGTDDEIELAELKREYLNFLMVILGNDLGAVLVSSTNQPIFESVITSIEHLARDVEDFPTAKMAFLLLSRMCSVWGGPDVVSATGNANAAGPQPALPGFDQFMITRFSPLCWALPTNPTFNSKDAQARQALSEAANLQKTIYTKTGQQYLTWLQENELRTMGMNDTLINDYLQKLATMELKAFKTFFPKFIAQGGQILRLETKVNINIRTFYLYRVEIVGMAKSKNSSQHNQAKKAHKNGIKKPKTFRYPSLKGTDPKFRRNHKHALHGTMKALKEVKEGKRDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK65</accession>
    <name>A0A1C1CK65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK65"/>
    <dbReference type="STRING" id="86049.A0A1C1CK65"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04988"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03006"/>
    <dbReference type="eggNOG" id="ENOG502RIGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="336" mass="37377" checksum="EA61CEE0EA9B9C37" modified="2016-11-02" version="1">MAPTSQAQPQPVSTYLPSLLQGLNQPDLKDVNNNQPIALQPLSQFIPAHLPPGMLPFPPPPMATQPPNVFPPPMGFPLQQTQFQMPPIVRLSFLLRHQHKQRQDTSVKYVDVIDLHDTITSILSHLGRFQPRPSASNAGQKLRRAMTPAVPTATKNPGQDGTRLVDALDQINIGHGAKHNRGATIGTSTTDTRVTAQHHTRNPSRPARNQRHATWSDEGIGDRKLRVSKWSDKLADYDSHLLERIPIVIVEVTAAGELEIESLSTRRSGQHDPVQEDQLLVRGLFEDSTRIPSWGFHTLATHLRIIPAPLLRITRIINIEVIHLNVGHLHHGANRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKE7</accession>
    <name>A0A1C1CKE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05274"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="111" mass="11882" checksum="CF47A6BF28D48508" modified="2016-11-02" version="1">MLTIWHFEYLQGTPSDQKPPPEYIVQNGHIYYQGPALGAGPGSRPPAPHPYPYSYSVDNPTRSRETESAYPVDGRPIAGSQTVVVKKESRAGPFAAGLAVGCCVAACCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLE4</accession>
    <name>A0A1C1CLE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynactin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_04771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLE4"/>
    <dbReference type="STRING" id="86049.A0A1C1CLE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04771"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02635"/>
    <dbReference type="eggNOG" id="KOG3958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4977at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="359"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT49307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="528" mass="57164" checksum="007B15D55C2D1DCA" modified="2016-11-02" version="1">MAVSKKYAGLPDLDAAPEVYETPDLADDVSTVPTGTVRTGSPSPSSGDEVRPGLDRQPLDRDGARRRFEPSLVDAKDVDFSDSIAGTRRAYRTRSSRRRRRRRRLEHGGGEEVGDLSDSEEETLPIKLARLKREAEEVRLELERREMEKDEDAEFQDSVEQQQQQQQQGSRKQGEEDVDADGVHELSRVLDGLSTKARLKTADTVEDQFLSTMASTARQRQHHLHHQTQASHSDPATAAPQSAPTTLAAVADFSDRLTGLESALGISSMSSDSQTSAILPTLASLAAQITALSATLAPPSTTSAGPEFQSQSRPNVAYLDTISSKLKTLIAESDRLSQSRKAALASLADLHEKRMQQLVSGASVHGNSRSARMRGLSTASSTGHTQGNNEAKVDGTTGGGGGGGGGPGAESLQIQSQLFLDEQASKITALYHLLPSIQELQPLLPVVLERLRTLNVLHNGAAQAKGLIDDLESRQREMKDEVAKWREAVEHVEKGITEAEDVMKSNVDVLGGRVRDVEERVGRLGQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLW0</accession>
    <name>A0A1C1CLW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Riboflavin transporter MCH5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MCH5</name>
        <name evidence="6" type="ORF">CLCR_06904</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06904"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09786"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="216"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT49525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="608" mass="65170" checksum="EAC8A38EEB3B6502" modified="2016-11-02" version="1">MTSKQAREHQDSGTPLGQATLARDASRPTRDQGLPPQPYPSSPAPTHDDHRRNSWWHSNTARPPPATSPVSTGVGSEQLAWKGSEQTLDAFTDSSMEGADNEKRSAIVAEKQSADAQENSQLRRPSLGSRKGTSAAPSIAAAPFTGPDCCDLERPHSHHGHGVLDKETCTSRPRSSSSSSSVPTLNQIPSNLATASRVSTDAYGNTYPEGGREAWLCVLGSFCGLMAALGMMNTLGTYQAYLSTHQLRGENESTVGWIFGIYAFLSFFFGVQIGPIFDAKGPRWLVLAGSILMLASHLIMGVCTEYWHFLIVIGVVGGTGTSLVFTPAIAALGHFFLRKRGQATGLAAAGGSMGGIVFPLTLQALFPKIGWAWSTRACALINLVLLIFANLFIRSRLPPRKATKENILPDFRIFRDPVFALTTAGVFFVEWGLFVPLTYLSSYSLRNGVSSSFSYQIIAILNVGSCFGRYFPGFVADKVGRFNAMVVTVALCLVSTLAFWLPAGGSIALIIVYALIFGFASGSGISLTPVCVGQLCRVENYGRYYATCYTLVSFGSLTGIPIAGQLVTACNGEYWGLIVFTSCSYAASCILLSAARIVGAGWKMKVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM29</accession>
    <name>A0A1C1CM29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM29"/>
    <dbReference type="STRING" id="86049.A0A1C1CM29"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06613"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09816"/>
    <dbReference type="eggNOG" id="ENOG502SF71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4159553at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="917"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="943" mass="99820" checksum="49A957FBF558A54E" modified="2016-11-02" version="1">MDKFKNMVKDNPDPAEDTSGPTGRLTGQGSHFPKREEQLAAGATGLQGAGATGFAPATDAESDSRIAPASGLSGLGSGSAAISETSTYSSRTLPPGDTVGGVVDPTSADPTTYQMPEHSYTSSRGIPEGGPLAAAAAAFHKDRDYSTSNLPGAFPKEPAYDSVTIAPSSSTSTANPPSRPATYGQTEDINMPDANAAAQSATSTASTTREPGSDEPRHTSTVGKILGAVGLGTAAAGAGVASSRARDDVSQPTTTTGVESYTAPTRSVPVSSDPELSEPAHRHQRKESIPTTAYPAGLESPAPINAPIGGTSASREPEYKDHTGRNAAFAAAGVGAAAVGAHEYGRDKELRQDVMDTPAHRTANTAAPAAVPQEFKQDSSRLGRETRETPATTMAQPERDAHGYGKTAGAAGVGAAAVGAYEYGRDKELRQDAIDTPAYGTANPAAPAAVPPEFKQDSSHLGQDTRETPVTTATERERDSHGYGKAAAAAGVGAGAGAAGMYGLQHDDRETERSDWPLRDDPTTAPAANAGLTSQGAMEKQPAVQTRQQDYTAYNVPPAKKTNQTIPERSAAPQYSDRQSRYEEPSQKDTARQEAARAGTAGTGTVASTVPDRSDEQAKADDDDAERRRRREKEATFAGAAGVGAGATGLHEYDKHQHEEDEARRQKDLAEQEEARRRQFEKDQKAATKEAKKEEKKQAKEEKAAAKEEKKHQKEVEKEEKKHQKELEKEDKEHRKELEKDQEHRKELEKEEMAHDKAAIAEQEKQQKRARDERERHEKEAAAAAAVGGGGAAAYEVHDKDKHPPPTTATDDSGHTKLHKDPPAEKKPGLLKRIFRRRKNKETGEEEEYEDAEDHEHELESEHGDHHIPATGVGAGTGATAGTAVATSHELPANSYEAQSGGAQKPSYNPFKKDDPASAASVSGTTASAHSPASGDFDPPPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMC6</accession>
    <name>A0A1C1CMC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative proline-specific permease put4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">put4</name>
        <name evidence="9" type="ORF">CLCR_06975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMC6"/>
    <dbReference type="STRING" id="86049.A0A1C1CMC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06975"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09904"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF21">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="48"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT49658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="552" mass="60816" checksum="A4BD324A6330E776" modified="2016-11-02" version="1">MEGEAKDIETGKAADTVVDTHQDIEDLKDLEREDRNVGTLERRLKSRHVQFLALSGAIGTGLFVGSGQALSLAGPLSTFLAYLITGFNLYAVINSLGEMATYLPLPGAVPVYAARFVDPALGFTLGKGWNYFYQFAIGVPIEISAAAVVIDYWPNAVSNAVWITILLIPMVVVNCLPVRIYGEAEFVFGAIKLTTIVGLILLMFIITLGGAPNHDRIGFRYWDNPGPMLEYLETGALGRFLAFWKVFIQATFSYGGSEMVVVAAGECENPRRNIPKAVRRVFWRIAIFYVLALFLVSMCVSAKDPRLLNAISSSAPGAAASPFVIAITNGGISALPSIINAVILSSAWSAGNSFFYASTRILYATALDHRAPAFLRFEKFGVPYACVGATTLLSLLVYLNVSSSSAEVFFWISNLSAVSTLIVWASVCITYIRFYHGLKYNGIPRSTLPYKSPLQPFLAYFAVCFCTIVAIFNGYDCFFPGRFSAKSFIPPYIDIPIFATLFIGYKVVKRTSFVKLSDMDLWSGKAEVDRLEGTWPEVKARNFLERIWFWIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMN9</accession>
    <name>A0A1C1CMN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_07393</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07393"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08693"/>
    <dbReference type="OrthoDB" id="2500381at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22921">
        <property type="entry name" value="HFD_CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018552">
        <property type="entry name" value="CENP-X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09415">
        <property type="entry name" value="CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="339" mass="37232" checksum="643844A10A11828A" modified="2016-11-02" version="1">MAPTAPSKRSRPPFSPPRPGISKVTKSAKGKMNTQSAPKQKSGANINVDSAVQKGKSKPNPTPTSAAKEKEKRKRGPKQKQKQKQKQRGAGGTMRALFDRGGGGDDEGDDDDDDDDDDHRRKRHAEEDGDDNEATLNDIAANMDTASDTDRDIDPDTDTHDRTDEFGSERGNFDEDRDKDRVDPRDDHDHDHEREAEDEDDQGNALSPSAGLDFSSPEPDFILAEVTHTDKQTHGRSKGAKSSSASAFAAASVLDTEEYPIPLPLMHRIMHAHFEDPATTLSQDARALMGTYVGVFVKEAIRRCADEKKERVSRGEGGDAGWLEVEDLERVGCQLVLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMQ4</accession>
    <name>A0A1C1CMQ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07436"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08714"/>
    <dbReference type="eggNOG" id="ENOG502QSGT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053152">
        <property type="entry name" value="Hydrolase_YcaC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559:SF3">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="229" mass="25127" checksum="E25CCC870728558D" modified="2016-11-02" version="1">MSYASYPPPPYRFERLDKDKAILLIVDHQLGLLQLVKDYTTAEFRNNVLAHAELGKLFALPTILTTSAENGPNGPLPKEITDMYPDAPFIRRNGEVNAWDNPDFRAAVEATGRKQVILGGIVTEVCTMFLALSLREAGYSVWANTEASGTATPKLAEDANRRMENAGVHLTGLFGVAMFLMKDWRNTPGTAEVLPFLDKYFPAYGIVARSHGSAKKSGEIVPGEEQLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMU7</accession>
    <name>A0A1C1CMU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative bZIP transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMU7"/>
    <dbReference type="STRING" id="86049.A0A1C1CMU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06961"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08748"/>
    <dbReference type="eggNOG" id="ENOG502S89P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37616:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37616">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 60-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="275"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="366"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT49826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="559" mass="61639" checksum="895E6EE9AA5DB903" modified="2016-11-02" version="1">MTYNSAHSSMAELNTNFNTDYDSFLIDSPDIKPVPMLTPQSSVPPSTTTPTFPGPSFQYDLYHQQTGIPRGALASTFNINKATGLQYHENNGGFIMPTETLNMPLSDLDDLDFSRNPGDMDFDDSPIGLPTMFFPENSSGPAQFVSPNTLVTPNNTSSTPIKRIYPGMHSQQAALAKAQQAQKQEQLARQQQQRPQGQKPLPGSSPTKTQPAKDPLVEESISKVLNRMRQASAASVSEDDDGASGGMSNMPRIKKDEDEMDEDERLLASEEGKKLSSKERRQLRNKVSARAFRSRRKEYISQLEGEVATKVQEANDLRVLNQQLREENNRLTDLTRMLLSSQAFSGFLQELSQSGLPPPNLQKNIQQPKPVQAQAQSQPQPMKKDVSSNAASQQLQNQPSQIGMALIPETPVDFSVLQPSNGWMNAVPTNDYHVYAVTELPPHPTLDLESLSGKSLPNKGSSKALKQVPRLPELPPSMMTTTAVEAPEVDDSIALDQNTFALYFNPSASENHCSSEGNDPDHAEEPAELSDEESMMNLKRMCDDLDDSCVKLAEFTSHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNC2</accession>
    <name>A0A1C1CNC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA repair protein Dds20/Mei5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNC2"/>
    <dbReference type="STRING" id="86049.A0A1C1CNC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07531"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08935"/>
    <dbReference type="eggNOG" id="ENOG502SAMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28527">
        <property type="entry name" value="MATING-TYPE SWITCHING PROTEIN SWI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28527:SF1">
        <property type="entry name" value="SWI5-DEPENDENT RECOMBINATION DNA REPAIR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="241" mass="27072" checksum="62EA44B3D751C562" modified="2016-11-02" version="1">MHPAKRRKLDQPQPFQNKPFRSPLRTVSKAQGRPARGQPQNLGTPVGVTPQLTPLVNSADGLNSPQKSHQTAANLHVGSARGKPADLQKQYTALTIRLTQLRQSLEKADQALQIEESGQGAELKRLITKWRTVAQEAADELFADAKERIDGMGGVAAWRRRAEQESLRWNRDEKGLLPQKYEPVANNVASLEDCLATDENKLSQPEEDDNENSFTMETMLQQMNIDLQAIGFDKQLERWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNP1</accession>
    <name>A0A1C1CNP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial distribution and morphology protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mitochondrial inheritance component MDM12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mdm12</name>
        <name evidence="9" type="synonym">MDM12</name>
        <name evidence="12" type="ORF">CLCR_07176</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="9">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MDM12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNP1"/>
    <dbReference type="STRING" id="86049.A0A1C1CNP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07176"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09004"/>
    <dbReference type="eggNOG" id="ENOG502S3PB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3356905at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21672">
        <property type="entry name" value="SMP_Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03104">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="65"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="187"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT50092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="446" mass="48055" checksum="F48CC7FBCD43ABC5" modified="2016-11-02" version="1">MSVDIGWETITSGPDGAALAEQVRAFVHEKFQQVALPRFINAVHVHSFDLGTVCPEIEIKDICDPLPDFYEDDDDSDDDGDEDETGADDERAKTAKNQSFERMRGNESEDAALSSRQPRPTPQLSDILTSSEFAEFAARGSTKPGQSAASAHPFSGPFPRSTTPGIPGGTSNLSYFHFPGSGLSGTQTPLAALASGTPFTPRPWSHDPADGAAFQHTPLHGPIQGGQLQRDLSGHYDPSTRPSTANSISSPRESESGLSSSPPSQNRHTPGADSRHASTLDDATALSPARLHSRQPSDLQVVASVKYAGDVRMTLTAEILLDYPMPSFVGIPLKLAITGLTFDGVAIVAMIKRKMHFCFLDPEDAAALVGEGHTGDQRTETRGRDGVGTGVPGLLQEIRVESEIGRQADGKQVLKNVGKVETFILEQVRKIFEEEFVFPSYWTFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNQ0</accession>
    <name>A0A1C1CNQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA-processing-splicing factor 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Prpf8</name>
        <name evidence="9" type="ORF">CLCR_06523</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNQ0"/>
    <dbReference type="STRING" id="86049.A0A1C1CNQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06523"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09039"/>
    <dbReference type="eggNOG" id="KOG1795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000386">
        <property type="term" value="F:second spliceosomal transesterification activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000389">
        <property type="term" value="P:mRNA 3'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="2131"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="2363" mass="274144" checksum="504646CC48A1CBF3" modified="2016-11-02" version="1">MASVPPPPPPGWGAGAPPPPPGMAPPPGMAPPPPGYRPPVDPRVAKFAQKKKEWLRTQRNRYGEKRKGGFVETQKADMPPEHLRKIVRDIGDVSQKKFSSDKRSYLGALKYMPHAVFKLLENMPMPWESAREVKVLYHVNGCLTLVNETPRVIEPVFHAQWATMWVSMRREKSDRRHFKRMRFPPFDDEEPPLSWSENIEDVEPLEPIQMELDENEDGPIYEWFYDHRPLLDTPHVNGPSYKTWNLSLPQMATLYRLSHQLLSDVVDKNYFHMFDRESFFTAKALNVAIPGGPRFEPLYKDIDPNDEDFGEFNAIDRIIFRAPIRTEYRVAFPYLYNSLPRSVKLSWYSHPQIVSVRAEDPNLPAFYFDPAINPISSRSVAPKNITVSHEDEIFGAGNNEDDEFELPGNVEPFMADEELYTSETASAIALWWAPFPFDRRSGKMVRAQDVPLVKQWYLEHCPPGQPVKVRVSYQKLLKSYVLNELHRKKPKAHNKQDLLKTLKSTKFFQQTTIDWVEAGLQVCRQGFNMLNLLIHRKNLTYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLMREILRLTKLIVDAQVQYRLGNIDAFQLADGILYAFNHVGQLTGMYRYKYKLMHQIRSCKDLKHLIYYRFNSGPVGKGPGCGFWAPAWRVWLFFMRGIIPLLERWLGNLLSRQFEGRHSKGVAKTVTKQRVESHFDLELRASVMADLMDMMPEGIRQNKVNTVLQHLSEAWRCWKSNIPWKVPGLPAPIENIILRYVKSKADWWISVAHYNRERIRRGATVDKTVAKKNLGRLTRLWLKAEQERQHNYMKDGPYVSSEEAVAIYTTTVHWLESRKFSPIPFPSVSYKHDTKILILALERLREAYSVKGRLNQSQREELALIEQAYDSPGTTLARIKRFLLTQRAFKEVGIDMNDNYNSINPVYDIEPIEKITDAYLDQYLWYQADTRHLFPSWVKPSDSEVPPLLVYKWAQGINNLTNVWETADGECNVMLETQLSKVYEKIDLTLLNRLLRLIMDHNLADYITSKNNVQLNYKDMNHTNSYGMIRGLQFSGFVFQYYGLVIDLLLLGLQRASELAGPPQSPNDFLQFRDRETETRHPIRLYTRYIDKIWVFFRFSAEESKDLIQRFLTEQPDPNFENVIGYRNKKCWPRDSRMRLMRHDVNLGRAVFWDLKNRLPRSITTIEWDDTFASVYSRDNPNLLFSMCGFEVRILPKLRNQNDEFPVKDSVWALANNETKERTAFAFLQVTEEDIQKFNNRIRQILMSSGSTTFTKIANKWNTTLIALFTYYREAAVSTVNLLDTIVKCETKIQTRVKIGLNSKMPSRFPPAVFYTPKELGGLGMISGSHILIPTSDKRWSKQTDTGVTHYRSGMSHDEETLIPNIFRYIIPWEAEFIDSQRVWTEYSQKRMEANQQNRRLTLEDLEDSWDRGLPRINTLFQKDRSTLSFDKGFRARTEFKQYQLMKSNPFWWTSQRHDGKLWNLNAYRTDVIQALGGVETILEHTLFKATAFPSWEGLFWERASGFEESMKFKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFLHGKIPTLKISLIQIFRAHLWQKIHESVVMDLCQVFDQELEQLGIETVQKETIHPRKSYKMNSSCADILLFASHKWNVTRPSLLFDTKDQIEANTTNKFWVDVQLRYGDYDSHDIERYVRAKYLDYTTDSMSIYPSATGLMIGIDLAYNLYSAYGQYFPGLKALIQQAMAKIMKANPALYVLRERIRKGLQLYASESTQEFLNSQNYSELFSNQTQLFIDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPKTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQLIVTRKGLLDPLEVHLLDFPNISIRASELQLPFQAAMKVEKLADMILQAKEPQMVLFNLYDEWLKTISSYTAFSRLILILRALHVNTDKTKLLLRPDKTVITQAHHIWPTLSDEDWIKVEVQLRDLILNDYGKKNNVNVQSLTSSEVRDIILGMEISAPSMQRQQAAEIEKQQLEQQQLTAVTTKTQNVRGEEIIVTTTSQYEQQSFASKTEWRTRAIATSNLRTRANNIYISGDDVQEAEESFTYILPKNILKKFITIADLRVQVAGYLYGSSPPDNDQVKEIRTIVLVPQVGSTREVQLPQQLPQHEYLKNMEPLGIIHTASGNETSYMPASDVTMHSRLMAQHPTWDKKTITLTVNFTPGSVSLSSWSLTPQGYTWGAQNKDTQSDNPSGFSTSFGVKTQLLLSDKIRGYFLVPETDVWNYSFMGAQFSTVEKRPVYVKIDTPKRFYDDLHRPVHFSSFNELEDIWADREDAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNZ7</accession>
    <name>A0A1C1CNZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger protein BrlA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNZ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CNZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07154"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05780"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="390"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="454" mass="50428" checksum="0AB66CFDCA02AF97" modified="2016-11-02" version="1">MSFNCQSEDSPSKKQIGSLVGPYSGLIVAAVYRPHTKVEESHFGLLPHIDPDFDRDSSLEYAGDCPSLSSTFFSSDGSTTDSHGHRRPSLASSVHSASPEAFWTPSATSMSPTTHISFEPSTQLSCRQDVKRAAYLSDNHPIFHHLQDEERDHHTVLWDATDDTSLPLLGSNHDLTMTEVAHPLYQLDGRGLNHGNRNPSLTKSIFTTPGACALIAPDDMLGLYPASVQPPAETIEPSVAFRGTLPSSPCYKVEPSTPLKGQMPSSVIFSSSPLSVISPRIVPSQHDVDDYSYASLQQALSRTKRQRGGNDRLQRRNYERKRPVGSSSNPKSSPTKTGMDCALVIEQNEFACSYPGCIDKHTGKQKRFKRQEHKKRHEKTVHEKTQHTTYTCWVPDCGRGFSRTDNLKSHLRNTHSKRPGVRGNRYVATLDKNSEFYDPDWVGELDKDGYPMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPG7</accession>
    <name>A0A1C1CPG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein psi1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">psi1</name>
        <name evidence="4" type="ORF">CLCR_07334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPG7"/>
    <dbReference type="STRING" id="86049.A0A1C1CPG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07334"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05603"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000136">
        <property type="entry name" value="DnaJ domain-containing protein Psi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="367" mass="39253" checksum="8919A29EA147FCD8" modified="2016-11-02" version="1">MVAETKLYDALSVSPSASQDDIKKAYRKAALKWHPDKNKDSPNAAEKFKEVSQAYEILSDPEKRKVYDQYGLEFLLRGGQAPPPGAEMPDGMPGGGFGGMPGGFSFGGMPGGGGTRTFHYSTGGGGGGFNFSDPNDIFAQFARSSAGAGGDDDPIFNLFGGGFGSGGRSAGSRRTTGNFSAKPQRPQTPEVTVIERPLPVTLEELSTGAHKKLKIKRKTFNAQGQRISEDKLLEMDIKPGLKAGSKIKFAGVGDQEEGGTQDMHFIVTEKPHPTLTRDGDNLITTIELDLKEALTGWKRTVTTIDGKQLNVSGAGPTQPGHEERFPSLGMPISKKPGERGDFIVRVKVNFPRSLTAAQKAKIKEALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPI8</accession>
    <name>A0A1C1CPI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_07467</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPI8"/>
    <dbReference type="STRING" id="86049.A0A1C1CPI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07467"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05585"/>
    <dbReference type="OrthoDB" id="195498at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="4"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT50416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="201" mass="22162" checksum="1912DEB1DE971D02" modified="2016-11-02" version="1">MAGLKEGDQFPDNVVFSYASTLNLIHAFVYIPYTPESADITSCGIPQNYNASKEWADKKVVLFAVPGAFTPGCSVRHLPGYIQALQELKGKSVDIVAVLAYNDAFVMSAWGKANGIKDEILFLSDPETKFSKSIGWTLGERTARYAIVIDHGKIVYAEKEPGRDVTVSLALFGSFLGSNTRRLGLQRWECDLCAGNFLVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPK3</accession>
    <name>A0A1C1CPK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative exs family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_07155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPK3"/>
    <dbReference type="STRING" id="86049.A0A1C1CPK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07155"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05587"/>
    <dbReference type="eggNOG" id="KOG1162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2159384at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="187"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT50413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="402" mass="46296" checksum="DACE492830847C12" modified="2016-11-02" version="1">MDGDVAVEPEVDSFSLILPLPYRVAIIIVLGIWAWGLNLHYLHLIKIDVPALIRYPPRQVAHHHYSTYRLATALSIPLVSSILLYWVITQGDKHTVLQWQILPQSYLLLLVVCFLAPLRRMSLSGRQRFLSILKRISLGGLAEVQDGKFGDILLADVLTSYAKVMGDLFVSTCMLFDRKTSSTAKPNRACGGVFLVPLIMAVPSMIRLRQCLIEYFRVRKHPTAASGWGGQHLANALKYSSAFPVIILSALQRGYEPNKFHMSEAGLFRLWLLFVFLNSFYSFYWDVAKDWDLSLFSSSRERNDPGHPWGLRRYRYFHAKELYYIAILIDFLLRCTWSFKLSPHLDHFNDLEGGIFLMELLEVVRRWMWIFIRVETEWVRNNKGPAPDDILLGEFGGKIDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPM3</accession>
    <name>A0A1C1CPM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07160"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05579"/>
    <dbReference type="eggNOG" id="ENOG502SP0F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF5">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="452" mass="50300" checksum="3C9E16D440116DC1" modified="2016-11-02" version="1">MANNQGATTRTRKAYVRKVTDKRREQNRRAQKAYRERLKKKLEVLEGQAASGFPQTDAAALSDRFLTVPSTEIIYAEGDVDRDDDSPASPPEVPRTETRQDSRVINLADAFVAAGDLPFGQGSLPGIQFQVAPETPTPEPDSEPVVEHTHHDYGDIWMAPIWAMPPNPASPHKQYPTPPGSLQGSRSSITLTSHRTSSGFSSPRSAMADPYMNHMRLVGEGNIEASIAIGLALKISRNQYLNDHPSHFPGCYVALNKPDPRAPTNSISPITVPYKIADTFMQITPRLQAHLEGVKPPIRPTPAQLLNPHPAYLDCIVFPYFREHAVKASADGILDHGKLFTDIMHGGLVCWGGMSGLSNRHGRSTKSGKRDMRESVAWSTRSWEAKKWFLKKWTWLIGTEEEEEARGDADGIWKGSRWWWTMRGEEDSDDEDEERGFAGERIHEVDAGGTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQB5</accession>
    <name>A0A1C1CQB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pcaC</name>
        <name evidence="2" type="ORF">CLCR_07735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQB5"/>
    <dbReference type="STRING" id="86049.A0A1C1CQB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07735"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05326"/>
    <dbReference type="eggNOG" id="ENOG502S4N5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="104509at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052512">
        <property type="entry name" value="4CMD/NDH-1_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570:SF2">
        <property type="entry name" value="CARBOXYMUCONOLACTONE DECARBOXYLASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="48"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="141" mass="15699" checksum="94A7748710993067" modified="2016-11-02" version="1">MANPQADQVTEAHKLFYDQGFQIRNEVAGSEHVQRSLQNNSSDFARPMQDLATEVGWGMIWARPGLTRQTRSLLNIAMLCALNRMTELAVHVRGAVNNGVTETEIRETLMQVAVYCGMPAGLEGVRVAEGVLRTLREQKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQK0</accession>
    <name>A0A1C1CQK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07855"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="71" mass="7994" checksum="81E3BD8B0729BAD4" modified="2016-11-02" version="1">MAYVRNSKELKMVLVHESLETMRQLQRPRGCVGSLHAAHVSVLPSWVRIIDAGTDPVAHMRAAFSQVLLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQN0</accession>
    <name>A0A1C1CQN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07540"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05215"/>
    <dbReference type="eggNOG" id="ENOG502SRDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5334491at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="178"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="254" mass="28157" checksum="21965B49A1DB9CA1" modified="2016-11-02" version="1">MLLPSAFSCDGGGLHPQSKPPRPKLPSFGAYQPQLSINAQPHPLSSSCRALQAILGAPATIQHTAPNPPRVLSNPFAPSEARGLSEKEEPRPLRGANKRRRSEFEDVSSDIVMEDCQRTPEPVRTPKRRRRVPLSMPLGLSADDFRALETPVEEVELDMPATSPHTRHSDEDSAYGSSPSQDDVAWTEADDRVLVETVLEKLKLSKRDWNDCAKILGKDRDSLERRWTLLVGEGNVGLRRGGRISRTNLDISSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR05</accession>
    <name>A0A1C1CR05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone deacetylase complex subunit SAP30 Sin3 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR05"/>
    <dbReference type="STRING" id="86049.A0A1C1CR05"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08830"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09568"/>
    <dbReference type="OrthoDB" id="510958at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="34415" checksum="2631D9CEA79DCEE9" modified="2016-11-02" version="1">MPPARARNVDDSRSETSSTITNQKEKSALGPTSGSGVSKGKKSAPGGHNGASAGSKAAVTGNGSTAAPAAAPPAVEADKDPSLPRARVEANFEQFAHRKKTEWDTMPVAVLRTYRIAHRLPVPAAFNQPHAELAYKSSDVGQRAPSVVYYRRKLHEQHLQRRRARQTQQQQQQTNGTGKTHGSKSKEKGKLKDTSMTDASSNTSLTIAQSIEPPDPNHPASERDASSVSSGPSTYLGPNQPVSNLAAVVRKHFNAQQLIGGEADTIARFIYVVQQNGSSRQVRTEGSEGDGSGYWMGGNGREQRRVDGPGGEVGFRLRFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRA6</accession>
    <name>A0A1C1CRA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRA6"/>
    <dbReference type="STRING" id="86049.A0A1C1CRA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08647"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09673"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="413" mass="46996" checksum="49255B5A16E63CB9" modified="2016-11-02" version="1">MVNDVSPAALGKTLTFIYHGDIPESYRKSLVSNTFSHLPLYQKFPITDKFLTTVRGKPMTVDLIDGTTRTTDTVTNKQKWAIMLSNQAALKDPYDMETCRDYAEVISEVDLYFAAEKLEIPALKGIAMDKVSAWFEVELQAGFPFSCDFRTCAIYVLREHREFAKLFIGVCAKYLPVVMNDSALVSLIEELHPMTWNAMMSVQHQWAARLGEAIQDLEKSKEHVSALETRHLQQKSASENFEKILESKVETLSRSLASAEARVDTAEATVRRLEDLQVSLQQQLLAEKVSVLKMEDANKAVQKYKSQSVKPALQKLAEKVEDLERAVACKDQALQQSRSANQKIKDDLRYENEGLRAEIGMMKNAFDLCKSFVNYEHDCPRCRRGWNIRIGHDQYTSISIGCKCCDFKKWYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRL0</accession>
    <name>A0A1C1CRL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Peroxisomal hydratase-dehydrogenase-epimerase</fullName>
            <ecNumber evidence="5">1.1.1.n12</ecNumber>
            <ecNumber evidence="6">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Multifunctional beta-oxidation protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CLCR_07987</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32711"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.n12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.n12" evidence="5"/>
    <dbReference type="EC" id="4.2.1.119" evidence="6"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRL0"/>
    <dbReference type="STRING" id="86049.A0A1C1CRL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07987"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09742"/>
    <dbReference type="eggNOG" id="KOG1206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000410">
        <property type="entry name" value="Peroxisomal multifunctional beta-oxidation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000013">
        <property type="entry name" value="Peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000185">
        <property type="entry name" value="peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ketoreductase" evidence="22">
        <location>
            <begin position="315"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="758"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00055743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00073871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OCT51113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="902" mass="97434" checksum="F0B35770E3B08480" modified="2016-11-02" version="1">MVQELRFDNQTVVVTGAGGGLGKAYALFFASRGANVVVNDLGGSFKGDGAGTKAADAVVDEIKAAGGKAVANYDSVEHGDKIIKTAIDNFGRVDVLLNNAGILRDVSFKNMKDSDWDLINTVHVKGAYKCARAAWPYFRKQKYGRVINTASAAGLFGSFGQCNYSAAKLAQVGFTETLAKEGAKYNIICNVIAPIAASRMTETVMPPDVLANLKPDWVVPLVAVLVHPSNTHTSGSIFEVGGGHIAKLRWERAKGLLLRADQTYTPGAILTKWDKVNDFSEPEYPTGVADFVTKSEESLKLPPNEQGEDIRFDGKVVLITGAGAGLGRGYALAFAKLGASVVVNDLMNPDTVVQEIQKLGGKAVGNKASVEDGDAVVKTAIDTFGRVDILINNAGILRDKAFANMDDKQWDDIIAVHLRGTYKVTKAAYPYMVKQKYGRIVNTTSTSGIYGNFGQANYAAAKLGILGFSRALALEGRKNNIFVNTIAPNAGTQMTRSILPEELVQLFRPEYVAPLVLALCSDKVPDPPTGLLFEVGSGWQARTRWQRSGGHGFPVDVKLTPEHVVSQWEKIVNFDDGRADHPESGQDGLKSIMANMENKSKKSDGAASGTDYLAAIEKAKKAQASGTEFVYDDRDVILYNLSLNAKRTQLPLVYENDDNFQVLPTFGVIPYFGAVAPFSMDEVLPNFSPMMLLHGEQYLEIRKYPIPTAAKLVSYPKLVEVVDKGKAGIVVTGTVTKDAKTGEDIFYNESTVFVRGSGGFGGPKNGTNRGNATAIYQPPKRSPDAVVEEKTSEDQAALYRLNGDRNPLHIDPEFSKVGGFKEPILHGLCFFGFSGKHIVQTYGLFKNIKVRFAGTVIPGQTLVTEMWKEGNKVIFQTKVKETGKLCIVGAGAELLGSPKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS29</accession>
    <name>A0A1C1CS29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dpm2</name>
        <name evidence="8" type="ORF">CLCR_09269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS29"/>
    <dbReference type="STRING" id="86049.A0A1C1CS29"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09269"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06791"/>
    <dbReference type="eggNOG" id="KOG3488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="110" mass="12190" checksum="975AD1694A641F24" modified="2016-11-02" version="1">MVRIPPVRRAGSPESANFSSKLDKLVGMAMLVVATTVFLYYTLWTLFMPFVDDDHPLQSLFPPRVWAIRIPVILTILASAVVGTFLAMVMIRSNRKKAAKARAAAAKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS63</accession>
    <name>A0A1C1CS63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS63"/>
    <dbReference type="STRING" id="86049.A0A1C1CS63"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08721"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06755"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="1">
        <location>
            <begin position="7"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="339" mass="38679" checksum="1A9519E02AE74E5D" modified="2016-11-02" version="1">MAIMDKVRVSIVSGRQQLREHDQPNDDPSSIGADELEWPLVTKVKYIEAIADAKFTIKCEVKPGFRFGSANCLDFDIWVDGQNIMGPMCPKSLVKSSRYGWTENYSGEDFWTGTTWARRPFRWSNLVTTDSSYTAEETEKYHNIGTIQVEVWRCWEEEVAPKESRKVYDTVESVPEKIVKGAALDMCTKLGSPVVNKKEHSDLSCKTTKIDEEPCAVFIFKYRSKGALQSLGILERPASPEPLEERDVETLSRDELKELARRLKVCIDRGWSRIDTDYGLQASREAQKVKIKQEKVEANVAQLAELKRVREDRDDEDDEVEFLSQRPVKKVCSIGGIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT53</accession>
    <name>A0A1C1CT53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT53"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08157"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06454"/>
    <dbReference type="eggNOG" id="ENOG502T60U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4155977at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="693" mass="75437" checksum="051E095E6382E5EA" modified="2016-11-02" version="1">MPGHVAQMQRLFQNAKASLRLDVRFASSPVGSIDSRLPNSPEEATNDITETGLLVDVRKEPPTETPSKNWRYSRAPGSLAGLETDVREPFPEGSPQLPAMLPLAVGHSNAFVAEPMSSGFTSPLDQPSFNLQVEDVSIVSSPPMPPDFGNESEAPDSPCPGEDMSASDLEHPMTKLRVDDDHEMDVDSADESPIITHLKRKSVDVEDKYRETSSGSEERIVLSPSARAAANSAKLKRGLFTDLFPRPPTHKGSSDGTLSSSGDAQNPSKRCPDPLLHEGGPAVLCPDPTAHFVSHVPNIAGHHNAIPVSNAYTGQHIASNAFGHPAVHFNRATATGSPMPLLKTRPPPASTMVGRGPGSWYPPTEFSTRPRPQHRYQSHHLNSAYILTASEHFQPGWYYAKDSPQSSPRPRPAMYSFSTAAAKVTGHDPAPDSMIRDSYRTDTLTPLAKPPSRFRKNGMSAIASARGANKHHGGAPFLSRPPQRRMHSVRARLPDSLKFRSSPPRSFVDPAQVPQPRKRARDLVSPTTEILEDETAQRELVDPRLRLEEGEEMIEVDEETRAAVRMSLFGAATPETGSETGSGLKELSPNVMLYRKGTGPSGSRKKRRPSYWDGDLEEVVRSPAARHVVSSPIKKDDVRSLQADVEFHDDDADKDNHMQAADSEHENVGRLAEGPMALQDAIGVESQGICGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU56</accession>
    <name>A0A1C1CU56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">vps26</name>
        <name evidence="2" type="ORF">CLCR_08651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU56"/>
    <dbReference type="STRING" id="86049.A0A1C1CU56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08651"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06099"/>
    <dbReference type="eggNOG" id="KOG3063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170071">
        <property type="term" value="C:CROP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="338" mass="38691" checksum="A7214866CECA0769" modified="2016-11-02" version="1">MSAFFFSTPVDIDIVLEDTDDRQTVDVKLDKNRREKAPLYLDGESVKGAVTIRPKDGKRLEHTGIKVQFIGLIEMFFDRGNHYEFLSLGQELAAPGELQHPQTFPFNFKNVEKQYESYNGINVKLRYFVRVTVSRRMADVIREKDIWVYSYRIPPETNSSIKMDVGIEDCLHIEFEYSKSKYHLKDVIVGRIYFLLVRLKIKHMELSIIRRETTGVAPNQYNESETLVRFESLGARDIRNTLRSCQACKSVRIKVLTRSVGETIPIRLFLGGFDLTPTFREVNKKYSTRYYLSLVLIDEAPDPPRVGVVSATEAPPVGFVSEPAGYSETLVLSSTPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUI8</accession>
    <name>A0A1C1CUI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vacuolar amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_08309</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUI8"/>
    <dbReference type="STRING" id="86049.A0A1C1CUI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08309"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05992"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="137"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT52163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="539" mass="58963" checksum="9833F482A54A5553" modified="2016-11-02" version="1">MPTDDEDSNGFIGKVPNGKIESYRHLLASADDTPSESRDRDSPTESVGHESRPPPLRQSSLSHPRPPGTPRTNNRVRFDLEHVASSPQPDEWVDEEDYLNSPSQRAPLLTDITPPSESPFLSESFQPEDYLPDARPKSGMSSAFMNMANSIIGAGIIGQPYAFRQAGMTMGIILLVALTATVDWTIRLIVINSKLSGADSFQATMQHCFGSSGLVAISIAQWAFAFGGMIAFCIIVGDTIPHVMEALIPGLRDVPFLWLLTDRRAIIVLFVLCISWPLSLYRDIAKLAKASTLALISMLIIIVTVVTQGASVDSELRGNLNGLLFVNDGFFQAVGVISFAFVCHHNSLLIYGSLKTPTIDRFATVTHYSTFISMIACLVMALAGFLTFGNKTKGNVLNNFPSQGHVMVQIARLCFGLNMLTTLPLECFVCREVMNNYWFPEEPYQPNRHLIFSSALVVTAMAISLITCDLGAVFELIGATSACALAYILPPLCYIKLSTRSWRTIPAVACIVFGFAVMAVSLILAMKKIIKNEGQHQQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV47</accession>
    <name>A0A1C1CV47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative trans-sulfuration enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_08633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV47"/>
    <dbReference type="STRING" id="86049.A0A1C1CV47"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08633"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09919"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000072">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000066">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT52355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="405" mass="44645" checksum="C54658DCFD707E2D" modified="2016-11-02" version="1">MAHEESSLDDFSLSTLALHSDDYCDGLQDEAAPLRLSTTFKYNKNPTELVPIPDRTTNDPDDYYYSRISAPTTYRFETALSAILNANAVTYASGLAAFHAALILLNPRRVSIGKDAYFGCQGVIDIVSRLSNTEKIALDCPAEDLHPGDLIMLETPLSPSGLALNIAAYAQKAHARGAFLLVSSTLAPPGLQDPFALGADLVMHSGSKYIGGHSDTINGILSTKNQHWANQLHKDRSILGNTLSGFDSWLGLRSIRTLDVRVRRQSESTQRIVDWLNSCIQGTADTSAVIAQAVTSIGHTSMQTQDMHWLEKQMPNGYGALFSLTMKSVHFARRLPSELRLFKHRTSFGGIESSVEWRRMSDVNVDERLLRFSIGLEDWQDLKKDLLAGMTMLVESEDPSLAEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW67</accession>
    <name>A0A1C1CW67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_09668</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW67"/>
    <dbReference type="STRING" id="86049.A0A1C1CW67"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09668"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04132"/>
    <dbReference type="eggNOG" id="KOG3742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="627"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="671"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT52783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="706" mass="79977" checksum="5B99926BC2AD9E6A" modified="2016-11-02" version="1">MNGDMEKKRDIKNHLLFEVATEVANRVGGIYSVLKSKAPVTTAEYGDRYTLIGPLNKNSAAVEVETLEAPAGPLRQTIESMQERGIELMYGRWLIEGAPRVLLINTGTGYRWLDEWKGDLWSAAGIPSPASDNETNEAIVFGYLVAWFLGEFISRETDRAVIAHFHEWLAGVALPLTKKRQMDLTTIFTTHATLLGRYLCAGSVDFYNNLQYFDVDAEAGKRGIYHRYCIERASAHSADVFTTVSHITAFESEHLLKRKPDGVLPNGLNVKKFSAVHEFQNLHSVQKEKIHEFVRGHFYGQLDFDLENTLYYFTAGRYEYRNKGVDMFIESLARLNYRLQNSGTKTTIVAFLIMPAQTTSLSVESLKGQAVTKSLADTVSNIERGIGRRLFERAVHWKEGDPMPDDKELVTPSDRVMLRRRIFAMKRHGLPPIVTHNMINDSEDPVLNQLRRVQLFNNSHDRVKVIFHPEFLNSANPVLALDYDDFVRGTHLGVFASYYEPWGYTPAECTVMGVPSITTNLSGFGCYMEELIENSSDYGIYIVDRRTKGVDESVNQLTDYMYEFANKSRRQRINQRNRTERLSDLLDWKRMGMEYVKARQLALRRAYPGSFTDAEDFDDFIGGTEQKISRPLSVPGSPRDRSGMMTPGDFASLQEGKEGLSTEDYIAWRLPEEEEPDDYPFPLTLKKKGSGPNSPAPLLGPVNGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWA9</accession>
    <name>A0A1C1CWA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_10497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWA9"/>
    <dbReference type="STRING" id="86049.A0A1C1CWA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10497"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04177"/>
    <dbReference type="eggNOG" id="KOG0223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47002:SF2">
        <property type="entry name" value="AQUAPORIN AQPAE.A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47002">
        <property type="entry name" value="AQUAPORIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="35559" checksum="DB425AD9F0473EE4" modified="2016-11-02" version="1">MDHHLTPGGSFDMEKNNSVHPRRSYTEAEPKSPQILSTSPPLPSDAVATDAFLGRLGGAQRFSLPSTSTATPSTPADALRDPPWSSILSFSDFRKPRLWKLALIEGVGTATQIFLSGVLGVAVLPTATETSVGAVFPVAIASIVQVFLISLFIYAAGPVTGAHFNPLITMGTFATRLSSLPRTVLYIILQCLGAIVGAYLVRAALGLSPRSLHVVPGCYIDSALVAPAEAFAFESVMCFVQLFLAFGLGLDPRNGTAFGPSLAPILIGLSSALTVFVGSFARPGYLGTSGNPARCLGFMAAGERFTYHWVHWVGPIMASTVNGVLYWLVPPYKAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWG2</accession>
    <name>A0A1C1CWG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">cut3</name>
        <name evidence="15" type="ORF">CLCR_09439</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWG2"/>
    <dbReference type="STRING" id="86049.A0A1C1CWG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09439"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04228"/>
    <dbReference type="eggNOG" id="KOG0996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1620:FF:000003">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="735"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="691"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1077"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1171"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="389"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="477"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="554"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1077"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1103"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1118"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1184"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1194"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT52887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1473" mass="164797" checksum="70D2C3253F400A1A" modified="2016-11-02" version="1">MSAESPVRPTRRAARKTIVVDESDDELSLIKEENDEEFTPAPKRSPRKSTRRQTTASANTSPRKSGRQRTAKTGDGIEPSQIFDPEETMPPSEPASPSKASSPSKRKSTVPRKSRKSLAAPPVPDLPTPDPSASPEAEHMHPTPLKDVTSQALNKNPQPQMSPDILKPPNQADVVMERPMDIVIRAKAQGLPVVEEPTGPKSRMVIRQLVMTNFKSYAGRQVVGPFHPSFSAVVGPNGSGKSNVIDSMLFVFGFRASKMRQGKISSLIHNSAQYQDLDFCEVAVYFQEVVDLPGGKHEVVPDSQLVVSRKAFKNNSSNYYLNGRTTNFTTVTTLLKDKGIDLDHKRFLILQGEVESIAQMKPKAANEHDDGLLEYLEDIIGTSKYKTPIEEAAVELESLNEVCVEKQGRVQHVEKEKNSLEDKKNKALAFIRDENELAEKQSALYQIYMAECEDNTKVTEEAIQQIQGQLSAELEKHAGSEDAIKELEKAYNKAVKQYERIEKQAQELTKELAKYDKENVKFEEKRKFITGKQKKAEKTATSSRLAASEAQSLVEKHSDDIQRKTSEVAELEKEMRIEEQKLAVIREDLQGKTQVFSDQIAVKQKSLEPWSEKINQKQSAIAVAQSELDILRDKATSGQKAIDQANAKIENIAAEKAHKLEEIEQRKHEKARLEKDVRKIQDALQKLASSEPEVRSQISSARQKADEARSSLASSQNQGNVLKGLLRLRESGRIDGFHGRLGNLGTIDEKFDVAISTACPSLENMVVDNVEVGQQCIEYLRKNNLGRANFILLDKLAQRDLSPIQTPENVPRLFDLIKPKDDRFRPAFYSVMQNTLVAQDLQQANRIAYGAKRWRVVTLDGQLIDVSGTMSGGGTRVARGAMSSKLTSDTTKEQVQKLEAERDQLERQFDAFQTRQRELEASLQEKQDEIPRLETAIQKINLEVDTCTRNLADAEKRVQDLMAELAGPSADDSQIQGLENQITLLNKELEKLHSETASLEAEIQALQDKIMEVGGLQLRSQKARVDGLKERIDMLNDDISNAEVAKTKNEKLKIKNEKAKADAEKDLESLSKDLERLEEDTEKHKSGAADLRGQAEKAEEEQTSMKEELGDLKKDLDSQMTELNSTRALEIEMKNKLEENQKVLADNHKKSRYWAEKLSKLTLHDIADLEGTSQSQDEEQPQQPKDEEMHDAPPEADPDAMDVDEGNPSEEQSPTPAHPVRSQLQTFTRDELLDKNKDHLVASIAALEEKVSNASSIDLSVIAEYRRRCDEVASRTSDLKSAIKARDGAKSRLTELRNLRLTQFMTGFTTISSHLKSMYQLITLGGNAELELVDSLDPFSEGILFSVMPPKKSWKNIGNLSGGEKTLSSLALVFALHVYRPTPLYVMDEIDAALDFRNVSIVAGYIKERTKNAQFIVISLRNNMFELAERLVGIYKVNHMTKSVTVENRDYLATGRQAIAPRAIAPGQPGQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWN1</accession>
    <name>A0A1C1CWN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10885"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04304"/>
    <dbReference type="OrthoDB" id="10267295at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="167" mass="18893" checksum="6E191708AB8CF08B" modified="2016-11-02" version="1">MPLHPAMLSSLGVKKKPDAPNLPSADKPFEQFLWLLKHQVVLLVPDFKDGAFKDKITWKTKLVDCFDILVHSPLLDKHEKGMLLEIIDGIERLADEHRTPGRKMTCEEMCVKHRDTFAGFFMMVQLDRAVNGMDVISQELRKGVLANLSFEGKCKDFGGLGVIEEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWW5</accession>
    <name>A0A1C1CWW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_09630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWW5"/>
    <dbReference type="STRING" id="86049.A0A1C1CWW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09630"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04354"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000266">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008448733" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="55"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="603" mass="64086" checksum="0B4EFF8BF94D3E18" modified="2016-11-02" version="1">MLVGTLFQTIFILLACGALTGQAYNPRPYLKALEARQSGSSGSPLRIDLGADGILRIRFAAPPTGSNRWQAPQAPEQNRSSAINASSFAPICPQGPDASYSVHSVNQTGADEDCLFLNVYAPANASSLPVLVWIHGGGYGGGNGRQDLSAIINSNNNSFIGVAIQYRLAALGFLSSDEVFRNGVVNAGLLDQHFALQWVQSYISLFGGNASQVTISGESAGGGSVMLQDMAYGGSLGTSLFVNTIAASPYLPMQYGYKDWIPSQAYYAFATAAGCPPGLPYGAQPQTIFECLVSKDTDTLINASATMSQSGNYGTWAFLPVTDGVFIQDLPSRQLLRRKVNGLNALVGNNANEGPSFTPQNVTTEEDLVAWLQLTFPLFTNDDIAKVLLYYPSSNDSTDSAAPLYGTSGNSGASALNQSSVGTGQQQRADNIYAETTFVCPSYWMVIAYNDLGRTSYKYQFSVPPALHGADVSGYFGPAAPNIGPDLALAFRQIWGNFVTKNDPSIPSDVAVGASAANSSTSTSANPVTAWPQFTMYAPYQINLNQTGGTPFSANITQIGHNITEFGSPGLVNDIALVDAWTWEAGRGYRCEFWRSMGAIVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXJ3</accession>
    <name>A0A1C1CXJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_09417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXJ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CXJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09417"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00213"/>
    <dbReference type="eggNOG" id="KOG0298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423221at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF26">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1346"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1612"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1620"/>
            <end position="1630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="2259" mass="251372" checksum="9029D873C89A18BC" modified="2016-11-02" version="1">MSSIVSEEDAASISAPSTGPDDSYHYGTRYEGEVKGNVRARRPSRPSTSQNPRRQKKSDERPEEGKVPGTNKHYKHYDLGTNASEVYMEFPDGLRRGVMPPPNKRVYRDIVLAPTESDGTSSATRGHQTKPGSEELQELRNVYGSRSRHPVAKALHHMPSVGQYSLTEDSETDEAVPAKKATARRARRPATNRRANSAAPPEDGPDEKDDSDDDGGDNKVGEHNRLDVTTYPLSDINQIFGLITEHAVNEGLLEASKVFGEQGIKVVTMCSGTEAPFVALDLIRKSLLSSEERERFKYQHLGSAEIEPWKQAFILRNFNPPIIFRDVTDFENHAANPDDEDCYPVTAYGKRVEPPRGAHILVAGSSCVDYSALNKIKSQWKGERGEGESARTMNGIGAYAKMYKPTVIIIENVAGAPWEMIKIFWSEKGYETVIVKLSTVDYYLPQTRQRGYLFGVHKDIADLAGFDIQQAHKEWIHLMAGFQRRASSPYSDFCLDEDDPRLRSLSHVVTDKWKRGGSTDWVQCRKRHVQERVTNKLGSGTPFTKRRGHSQAQVDDYADQAWALKQSKRVLDMLDIRHLDDVARRDFDMRFKHRNINVSQNVDRDRDNRQWGIVGCVTPSGCLFETRRGGPLTGLEILGLQGFPTGDLQLEKYTSNQLQDLAGNAMSTTVIGPAILSAIMACFRVHEDNDGEKQIFEVTMDEYHDSNEDQPMEDAPLREAFDERELETNPNSKALVPLKEEFPHIRATEEGPYSLTSIVEKARDLQPLCRCEGLHRRTSEDIIYCPDCYYTCCKGCSRDTHGHKALSKLEISTSHRPVAGTFAKLLIQILPAALENHNAGASLPSFTDSSAEEIELRISEALQSQVHFRGVKFEGSWKALYESEHALLELEFVPHRHMCDPCEEHERPHLHLDVAPVWFLFTKAPATEPVKSKMRKLFRHPIARMTPDDNLFSGRWKLWDGPTQSSKVHIVRAGEQVASWERSLGLEQMPFRDLNSFSAIEVSPSTSVNVKAHSLVEEIAGIYELLPHCPAPNGTLHRRVSGSALGKAPSFLFLQSKPLQDGRLDRVVFSNQPFRPNAIDDRTVLAALDRTWRPVATAEVYEGEEVLCDPVSLWSDCPVQELQIPRDENTVCKWVPRKEADPMSAAACVNALSTIMLLDLTCDANARARLENRRGICIVLERKPQALSDFGWILSHAASIPHPWNEWQNIDFSEAVECATCSPAQPCIKWLLKKSGASETVKAMESPLEAAEYENALGNRPNPAVALLRDIDGEALLDVKINIKTLAHRAVAPFLVNLSPDSELQSLQWRVDPYNQFSPNPKFALPKLLSNKLDKVDKSLKDKIHLKRDLWKSQLQALAWMIEQETSPKAWDEMSLTESCLPALGWRLEAKALFRKHNVRGGVIADEVGAGKTTTSLALVKYDYQHSQTATTTGAESDEDDGRPHIGKLETNATLILVPKNILSQWEDEVGKCLNWHKLPPTEKHGLEQRAPYYITIKDVPDLQKYSHEQIKSATLVLAAWDLLGHKSYWNYLRKIACSACTPEDPGRAFEEWLKETLPCLETCVEGLKTSVADFWTAWDNVRQRTETDHKYENFEGFLTRQAKRAMMAKERADAKNKAGKANGTTGNKAPQDKEAVDAQIKETALQKSRDELDGFRRDAHRQGQPMPPPVLLHMFAFRRLIVDEYTYIEGETLLALLQLDAARRWMLSGTPAIQAYDSLNTTAKLIGTQLAAYDEHEGKFGFGKDATRMTRDKSHGQEIQSYQNVASAAFKEAVYERASVFSHQFIRKNEPSQGRAEVSTCLSQVALSPSEWITCSDVQSLAMDPDRPFGKPQPTTKVDMNKEVPASIWQLTDLVERTASPQDARICSSFMLEEIWPVVRGDAGRSLDRQLIGAEKHRMKQIIMEQTEHVRARTSELLPLLQELWHMHRLVRHGDKEAAASFTGLRASVSSGTLADMHAVAVVGSLLGYARENEAVPALLLSKTKKNPAGAGRVNLPWDAAEMRNAAVAVKEFDLRIAQVENHVEILMRGLRRLRLLKAVLGAFEQRLGECSGCGAALAWEAAVVSTSCGHVVCSECASEACCAAGEVGDVVPVSRFAVSYVGAEVPGTVTCSRLRLAVSLVHGAIAATDSVLVFAQHKGIKNAFIEACGEAGVTCLDGFEAGSAARAVEAFRAAAPACLVLKVDSADAAGWNLQSANHVVFLSVPVLGSVAEEEATREQAVGRCWRPGQTKQVFVYQVAAAETGELDLVVRERGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY10</accession>
    <name>A0A1C1CY10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="10">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lipoate synthase</fullName>
            <shortName evidence="10">LS</shortName>
            <shortName evidence="10">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_10298</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="10"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY10"/>
    <dbReference type="STRING" id="86049.A0A1C1CY10"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10298"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00335"/>
    <dbReference type="eggNOG" id="KOG2672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="144"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT53366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="417" mass="45636" checksum="8935D4329470E8FA" modified="2016-11-02" version="1">MAATVPRCRCLNGRQWSSPFKVFLPQATPSTSRSFATTTDDIPTAKPRVQPTTFADKLNAGPSFSDFVSGKEPPLQPSEAYALKTALVGPKGKQKRITRLPEWLKTPIPDTSSYKKIKNDLRGLNLHTVCEEARCPNISDCWGGSSKSAATATIMLMGDTCTRGCRFCSVKTSKAPPPLDPHEPEHTAEALSRWGLGYVVLTSVDRDDLADGGAHHFAETVRKIKSKAPAILVECLTGDYAGDLEMVKLVATSGLDVYAHNVETVEALTPQVRDRRATFRQSLSVLQAAKAAKPGLITKTSIMLGLGETEEQIFDALRELRAVDVDVVTFGQYMRPTKRHMPVHEYVTPDVFEQWRVRALEMGFLYVASGPLVRSSYKAGEAFIENVLKKRRAGRGDTANADLAREIDGKGLESGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY24</accession>
    <name>A0A1C1CY24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">60S ribosomal protein L14-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RPL14A</name>
        <name evidence="9" type="ORF">CLCR_10787</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY24"/>
    <dbReference type="STRING" id="86049.A0A1C1CY24"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10787"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00372"/>
    <dbReference type="eggNOG" id="KOG3421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000030">
        <property type="entry name" value="60S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="8">
        <location>
            <begin position="57"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT53405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="148" mass="16460" checksum="A0098DC88C463DFF" modified="2016-11-02" version="1">MSNVDIKAAGWKLVEVGRIVTIRAGPYDGKLAVVVEIIDPGRVLVDGPSSKEGAVVPRQAIATSTLSLTPWVIPNLPKAAGTGPVKKLWEKNEIDAKWAESSWAKKREQQERRRNLTDFERFKVMRLKKQARFETLKAQAKVRATAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYH0</accession>
    <name>A0A1C1CYH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sister chromatid separation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_09642</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYH0"/>
    <dbReference type="STRING" id="86049.A0A1C1CYH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09642"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00416"/>
    <dbReference type="eggNOG" id="ENOG502QVG5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2503928at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12935">
        <property type="entry name" value="LEM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025856">
        <property type="entry name" value="HeH/LEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12949">
        <property type="entry name" value="HeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HeH/LEM" evidence="9">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="8">
        <location>
            <begin position="321"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="671"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT53450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="716" mass="78711" checksum="E53383C290E5A5E3" modified="2016-11-02" version="1">MADEDELYYLQPGFDLNTLTVPRLRSILVAHNIHYPSSAKKSQLLEILGNELLPKREKLLRAQARVRRTSKGITDVPSSQESTISSDEGDDRQLMPPPPAPRTPRSRKSKSDLAAEESVGRAPSTSKRTKTPSRRSVTRTPRASDTEHTEPEEAKSTVRRPRKSAPTQPVLEPAVKIEEPDARLKRESLEAGTSPFSDENPFQSGSSPPSASDRRKSASRSRKSLSSTTTTKRGQTSSTSLKPEDSPPSRSTVSFPISRVMSADTEDGVTTTEEFTPDAARELAEDEQNGQLVPGRTSTLVRRKKKKPTGPIAKTAPLAILTSVLGALGAWYRQEKINVGYCGVGEPNWSLASNPHIPAWVHENFQPSCEPCPQHAVCYPNMEVECETDFVLKPHPLSLNGGVPLPPTCEPDSEKQRRIKAVADRAIEELRERRAAYECGEEVTAPSNAVARETQAAKAVAKPTKSQLEITEEDLKQTVSKMKRRGMTDEEFEDLWRGALGDILGRDEVQVTQDRSGRQLVSSSSLARLPFTCAIRRSVLRAIAENRIPIAILILLVSGLAYGRNQIITHKQNTARIPGLVATTLDRLATQASLNQEGRVSEPFISIGQLRDDVLRSVFSASERERVWRSVRRIVEGNSNVRAGNREGGKTGEVSRVWEWIGPVDLAPGLEGRRSGGLITDGRAGGSSSPGEDGVVKAEDRSNMETRRWDEGRAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYI7</accession>
    <name>A0A1C1CYI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">crnA</name>
        <name evidence="7" type="ORF">CLCR_10487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYI7"/>
    <dbReference type="STRING" id="86049.A0A1C1CYI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10487"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00558"/>
    <dbReference type="eggNOG" id="ENOG502QPIC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434240at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT53603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="340" mass="36860" checksum="A75A2903D4B97F7E" modified="2016-11-02" version="1">MPSIYDSLVSDGLTPHVAWRVTFIVPGIVILFVAAGLLLLCQDTPVGKWSERHNAAQTNLAAHGVQATIVDRPQVGIADKPASLSSGTGSPPAGEKMQYDATGERKQSVFFDHEAQLSERQMLDTARGEIVVKPTIMQVFRVMFAPQTLVQAFCYFCSFGAELAINSILGTYYQKNFKQLGQTTSGQWAAMFGLLNVVTRPLGGIIADLLYRRFPNVWIKKIWIHTLGIITGVFLIVIGVLDPHDTSTMFGLIAGMAIFLEAGNGANFALVPHVLPHANGVVSGMTGATGNFGGIIFAIIFRYMKTDYAKSFWITGVITIGINLAVCWIPPVSKKQIGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYN4</accession>
    <name>A0A1C1CYN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome c oxidase assembly protein COX15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">COX15</name>
        <name evidence="13" type="ORF">CLCR_10299</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYN4"/>
    <dbReference type="STRING" id="86049.A0A1C1CYN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10299"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00565"/>
    <dbReference type="eggNOG" id="KOG2725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1726137at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT53612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="417" mass="46186" checksum="4B43C271BDDBEFE9" modified="2016-11-02" version="1">MSEADWESEFAKYRSSPEFKMLNSRMTLDEFKSIYWMEWIHRIWGRFIGLSFVLPAAFFIARRQVSRSMAARLLGIAGLIGFQGFIGWWMVKSGLKDDLFAPGSHPRVSQYRLTAHLGAAFICYLAMFWNGLDILRTNKILRATPDTANATLNALKNPALRPFKRYVAFLAGLVFITAMSGGLVAGLDAGLIYNEFPYMGLGLTPPKTELWDKFYSRAADNSDLWWRNMLENPSLVQLDHRILATTTFTAVMALWAFARSGAMQKVLPRAAQRGVHGVVGFVFLQVTLGITTLLYLVPTGLASAHQAGSLALLTWTIVLGSRVWFPTQAARILAQRTATQAHLGSRSTQNAPEMLKAKSNELLPARPAALATAGIMPLVTGIGLILSTEAEGTLRDQLSKRGLKKLSSSRDEQVRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ09</accession>
    <name>A0A1C1CZ09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ09"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11088"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="86" mass="9381" checksum="1D183F048282F02A" modified="2016-11-02" version="1">MGRRRDAKWITRRDGGEDEGVVAGELDPVHQDAEVRHKVTVVRSRSEMPPGGDSPQEVRGIVGRIFTFTVMRPGVVGLISESSPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZB4</accession>
    <name>A0A1C1CZB4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fad binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZB4"/>
    <dbReference type="STRING" id="86049.A0A1C1CZB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10336"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00802"/>
    <dbReference type="eggNOG" id="ENOG502SNJI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="72269at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="381" mass="43212" checksum="D1E1B8310B4BF0F3" modified="2016-11-02" version="1">MTRPSAPPARRNGTGILFALIFAILSVCAVYALRIASVQSGIADKMERITTTHRFLEHPLSLRTTYTGIAPVDQGLSFLVTAFMNAASGWDAGFFVFLGYFLVSFFAIVTLWAVESCRERNGRALTRFTYIYALLYQTVGGAVIVPIYYLVYLYDTSSNSYWSKPRNIPLPYAKALLPALIIGYLIPTVLIFLPYSAPDMWTTQAAVAFWQPSPWYVDILIWVFAKLYSGGSSTKSRSPNRNSDIPYLNRIYLTSFLVTGMLHLFIIYLMLFSPNPKHSFSHMFLDPFSYSSTQMSMVQGMHGIFLADFWIIFASSMLWAYLAIWDLKRVRLADVNLWTVVILLAISTVAVGPGAVVTGVWYWREKQLTDLEKEKEKEKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0S1</accession>
    <name>A0A1C1D0S1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0S1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00980"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="116" mass="12371" checksum="8408AE4A0B866C05" modified="2016-11-02" version="1">MSIPALSRQEAAFAHCGSWPNGLGHRIPDPSQLRPSSVAISPPVEAAVRDRKFPFPMQLFVAILRLDSVRLATLAPSSGSSIAIPLASVSVLIIFHLDRGSIPAVPNHAFTVLFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D106</accession>
    <name>A0A1C1D106_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_01010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D106"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01010"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="93" mass="10451" checksum="B214D8879E002476" modified="2016-11-02" version="1">MANRLFETDESILQLRVEAHFDSVYHSAAGIGIGNLLNSAKSPLRLHTLENLLNSFKVHLLSKRSLAQTMWRSISKSNVADTAYTVEVELPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D113</accession>
    <name>A0A1C1D113_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative 26S protease subunit rpt4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rpt4</name>
        <name evidence="12" type="ORF">CLCR_00868</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D113"/>
    <dbReference type="STRING" id="86049.A0A1C1D113"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00868"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01659"/>
    <dbReference type="eggNOG" id="KOG0651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="170"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT54391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="393" mass="43949" checksum="6D5769C1CB0F4D6C" modified="2016-11-02" version="1">MDGNGDPERQQALEQYKNKLLESREWESKLKALRMDIKGLQKEFETTEENIKALQSVGQIIGEVLKQLDEERFIVKASSGPRYVVGCRSKVDKSKLKQGTRVALDMTTLTIMRMLPREVDPLVYNMSLEDPGQVSFAGIGGLNEQIRELREVIELPLKNPELFLRVGIKPPKGVLLYGPPGTGKTLLARAVASSLDTNFLKVVSSAIVDKYIGESARLIREMFGYAKEHEPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQLDGFDYLGKTKIIMATNRPDTLDPALLRAGRLDRKIEIPLPNEVGRLEILKIHAAGVVTEGNIDFESVVKMSDGLNGADLRNVVTEAGLFAIKDYRDAVNQDDFNKAVRKVAEAKKLEGKLEYQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D133</accession>
    <name>A0A1C1D133_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit J</fullName>
            <shortName evidence="4">eIF3j</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 30 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF-3 30 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hcr1</name>
        <name evidence="4" type="synonym">HCR1</name>
        <name evidence="6" type="ORF">CLCR_00905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D133"/>
    <dbReference type="STRING" id="86049.A0A1C1D133"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00905"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01656"/>
    <dbReference type="eggNOG" id="KOG4813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20381at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT54388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="275" mass="30276" checksum="352239967A44AA29" modified="2016-11-02" version="1">MPPSKWDDESEESSEEESIDVPVARRKFADEEDSDAVADNWEEEEDSEAEREKAAKAAAAKAKAEAEAAANKKPKSQRIEEHREANRRRRAQEEEEESSEEEDDAEKRARLRQSEQDADLKHAQDLFANVGMGPKSRTAPNKAVIIEDKANPGQAIDLSKYPLFKPATKSQFDALSATLVPLLTAASSKPHYSLWVSTFVKQICADLPSAEIKKAASALTALSNEKMKEEKEKEKGGKKSKAAKTKSSLAATRDMGRGVADTTSYDDGLGEDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D142</accession>
    <name>A0A1C1D142_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vanillyl-alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">VAOA</name>
        <name evidence="6" type="ORF">CLCR_02890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D142"/>
    <dbReference type="STRING" id="86049.A0A1C1D142"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02890"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04679"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF114">
        <property type="entry name" value="ARYL-ALCOHOL OXIDASE VANILLYL-ALCOHOL OXIDASE (AFU_ORTHOLOGUE AFUA_3G09500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT54573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="484" mass="54712" checksum="DDBDF3301C429C7A" modified="2016-11-02" version="1">MGSPASIDELRAVLAIANKHGIPVWTFSRGKNLGYGGPAPRLNGSVALDLHRMNRIIEVNDKFSYAVVEPGVTFTDLYLYCAKHKLRVWPSVPSLGWGSVVGNTVDRGTGFTPTATHHQHISGMEVMLADGDVVRTGQFAISNSPSAHLSKFSFGPSIEGLFLQSNLGIVTKMGIWLHPQPQAYMSCSWDMPNFEDVETIVDIFGDLRRDGLLPNTVYVSNIVEWLGMTGKRAELWPEEGPIPDWRLRELQKELGFGYWNVKFGLYGAKDVVQSHFNELKRIIRKKASGHEDRLVGQIFSGENDELLEATSIPEPHGGFFVGVPSLWSLPMVKYRLPKEKAGIGAHADYSPIIPSDGKTVLEWVTTARKICEAQGFDLFCDFFMHERHVIFVNMMVFDKSNPEHRRAVDTIFRSLYKEGRQRGFSKYRSHINYMDLVADAYDFNDHAYRRFVERLKDTVDPNGILSPGKQGIWPAKYRKFREKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1G6</accession>
    <name>A0A1C1D1G6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_00945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1G6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00945"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="153" mass="17272" checksum="9EF84DCDE8F274B7" modified="2016-11-02" version="1">MQPQSESSSRPLLPRNKSFQGDQVYDNSFVTFDIGTGQLDPFNACVPAYLSLDILDYVWSINFAGATHKAYLQRGADIRSRDRTLRLSYKTNAIKELNREIQGLQGVAYDELLLAIITMTAHGSGEQLDQPSQEEILSTLESVQSFQYFGRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1G7</accession>
    <name>A0A1C1D1G7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative amino-acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_02858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1G7"/>
    <dbReference type="STRING" id="86049.A0A1C1D1G7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02858"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04690"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF29">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="561" mass="61125" checksum="ABAD64BE7537F06C" modified="2016-11-02" version="1">MASPRKGSVTVVDENAVGVTSVFAQQHSHAVLEEGATKDEVTLAALGYKQEFKRDFTIWESFSVSFAVLGILPSVASTIAYSLGYSGTGGAMWGWLIAALIIQSTAFTMAELCSSMPTAGGLYYASAVLAPEGWGPMASWFVGWSNFCGFVTGPCSVNYALASMLITCGMIANPEYEPKTWHIYLTLLLLLFINGLVTMQSTWFIGWLNKIGTIWNILVLLIFVIWFPAGSINHPKTNNSHDVWTKFENGTEWPIPWATIMGFLTTIWTMSGYDAPFHLSEECSNANIASPRAIVMTAQLGLYLGWVVIWVICYTVKDIPDVVAGQYGQPFGSLCLQVLGKKAGLAMFSLNIIAQFFVGESCTITATRVVFAYSRDGAIPGSRWWSQIHPKTKTPVYATWGVLGVGALLGLLMFASPVAIGAVFSIGAIAQYTAFTTPVALKLFFDHGRFKPGPWHLGRWSKPLGAVAVGWWCLITPALCFPAVKGGDLNALTMNWTCLIYGGSMFLAMSWYTIDGRKWFKGPRINVHVTQDGMEVLEGQSGHSSSENKAADSEKEAIKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1H7</accession>
    <name>A0A1C1D1H7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1H7"/>
    <dbReference type="STRING" id="86049.A0A1C1D1H7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00935"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10134"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10019231at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF55">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="248" mass="27529" checksum="EE8C39A0BBDF7AFF" modified="2016-11-02" version="1">MAVSTCCLKSFAWEGTPTGQTSTLGPLNTYIAGTNSERAILFVHDALGWTFPNARLLADHYAREVDATVYLPDFFGGETLPFEPILAGRFHEVDFAGFLERNSRPIREPEIFDAARALRQQYKKVGAIGFCYGGWACFRLGSKDHDPPSLVDAISVGHPSLLTKKDIDEVAVPVQMLAPEHDVAYPLDMKVHTFETVMKNGLPLDYIHFPGVEHGSLVRGDAGLKGEREAMARAKDAAVNWFKQWLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2P5</accession>
    <name>A0A1C1D2P5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyltransferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_02778</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2P5"/>
    <dbReference type="STRING" id="86049.A0A1C1D2P5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02778"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05040"/>
    <dbReference type="eggNOG" id="ENOG502QVIM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06421">
        <property type="entry name" value="CESA_CelA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF2">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="700"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="770"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="9">
        <location>
            <begin position="367"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT54950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="789" mass="89580" checksum="F512464322C6D9E4" modified="2016-11-02" version="1">MPPLRKSDRRRAEQQPVMTEIKLSAIESPSPYRESMSSPYHESHRESQESFLEPPPSAHPIYGNYRESPPLEHQRLSRRPGLSDLHDRTLSDLIPESISDSTLVAPNGSYPAFAPGAHSSYSGSQTRSSSPYPVPSPFRSQETLRPLYPDSPSTYFKKDWAKEGQIAQLHTRDDQEFIAGKKRWLYRWFAPLLCLVSLSMYWFYFGLRITFIVDAQRLYGNSFPLAWVFVAIEISIAVPIFMQTIWSLFILKKRHRPKLRLIGNEVPTVDVFITCCGEDDDLVLDTVRAACDLDYPQDRYRIILLDDGKSDTLKNVLEEWRETCPNVFYMRRPKFPGVPHHFKAGNLNYGLDAVHNLPGGAGEYMAALDADMIPEQHWLRAVLPHLLMDDKMGLACPPQLFYNVPKDDPLCQSLDFFVHVSEPVKDALGVAWCTGSGYVARTAALAQIGNFPCGSLAEDVATSTLLLGAGWKTAFVHEALQFGTVPEDYGGHLKQRTRWAIGTVDTAFKLKFCLWGDQVKHMSFAQRSSSFIYAFLSLFNIFLTLSIFALPIVLVSNKPLVAYSNDTQLRWLIRACFANVVLNRLCEFVLYIPAGYTTGQRGSRYQLWMAPYISLTIIRSFVLPTWLGGQRQAFKATGSIKSALNERDPKQRAPMYRRLWTICVNYMAGFHVAYVYFVLVAVTISTYRTLIVQHTLRGKLIGLVTHAFWPPLAWIIVCSSFWIPFTYAVDPPNCPDREELLDRDPKTGVCHPKPEAKKIAFAPQTAWFELEYTLTTAFTALVFVAAFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2Q3</accession>
    <name>A0A1C1D2Q3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2Q3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11450"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="117" mass="14818" checksum="0EE421ED271FB2BB" modified="2016-11-02" version="1">MNMHMKMNVHKYEDERAQKKKKEKKKKKEKKKKKEKKKKKEKKKKKEKKKKKEKKKKKEKKKKKEKKKKKEKKKKKKKKKKKKKKKKMMMMMMMMMMIILNLRYLRSLKALSQYRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2U4</accession>
    <name>A0A1C1D2U4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 62 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2U4"/>
    <dbReference type="STRING" id="86049.A0A1C1D2U4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03009"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05147"/>
    <dbReference type="eggNOG" id="ENOG502S17G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF6">
        <property type="entry name" value="MANNAN POLYMERASE COMPLEXES SUBUNIT MNN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT55054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="345" mass="38822" checksum="096A0E34A288E473" modified="2016-11-02" version="1">MKRRVRGLVALILLVVLFGTTLLVLDTSGWLHRASVSWNGHHQTKPARRPHSDAEGAHHETKEQRDGHVMRHERALAAADPALLWLVLTYDETSWGLAPGLILKRQRSFEDFLELLMAANLDLQNVSLGLMTSSEAEYHHFIRATEDIPVARLTILMHPGFNTTAALDRKHRHDSEAQTARRTELAQLRNYLMLSTLRDERHVVWLDADVYYLDEGIIQRMIAHSESREDAGIITARCEAPWGPNYDLNAWAGPHKHAHRVPELVKDTSDDDLVPLTSVGATLLYIRASLVRQGVNFPPYYVINTKWTETGTDGIESEGMCYQARGLHGGGCFVLGGSWHTKHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2V3</accession>
    <name>A0A1C1D2V3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000001">
        <property type="protein sequence ID" value="OCT55116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2V3"/>
    <dbReference type="STRING" id="86049.A0A1C1D2V3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00009"/>
    <dbReference type="OrthoDB" id="5402991at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT55116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="636" mass="71572" checksum="486A56DADC3BE200" modified="2016-11-02" version="1">MSIIDSIGGLFNAAAERKHQEKMQEAQLAHESEMHDKDLAFSREQMDQQKKQFDDTLGFQKDQFHAAEDQRGKDNEFRDDQFQASEDQRKQQNQWIDEDRKRQQGRQDKQWAEQDKQIAKIDAMQAQVDEYLQNEEFNTRASFLELAGNAVKTATFSQYNILIVDDTEADIIPKGELEGAIPVDPLKLQISSKGNALFRVHMFKSGEYLRKGSLKDDMLWVWPATARRAAIAYNGPTDDGPVLQRPTDDDPTNIDDQINNDPSLPQVDPVMQYYFSGAYARGETIDRTTLTKDQRGWLDYWKAGQDAMKTGSPMPDDQIDKKLEWEQQIKARDDAIKAKKKELEDQKYQTDQSKAYEQYVFTTPKEENVTEAEMIAECDKQTKKMQEQAARIKKQLAAAGLGGAAGGSATGPGQDPSMDPSMGQDPSQDPNYDPTQDPNYDPSQDPNYDPTQDPNYDPSQDPNYDPTQDPNYDPSQDPNYDPSQDPNYDPTQDPNYDPSQDPNYDPTQDPNYDPSQDPNYDPSQDPNYDPTQDPNYDPSQDPNYDPSQDPNYSAEGGMGPDHTGHDGMEDEGGYSDQQGGYRGGQSYGRTGSMEYEGMGDDGMGDDGMGDDNGYLHQQGDYGGGGYNGQGQQQIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2Z9</accession>
    <name>A0A1C1D2Z9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein cms1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cms1</name>
        <name evidence="2" type="ORF">CLCR_00025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000001">
        <property type="protein sequence ID" value="OCT55121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2Z9"/>
    <dbReference type="STRING" id="86049.A0A1C1D2Z9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00025"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00006"/>
    <dbReference type="eggNOG" id="KOG3089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1929311at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032704">
        <property type="entry name" value="Cms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14617">
        <property type="entry name" value="CMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT55121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="299" mass="33525" checksum="43B341044BAC5D83" modified="2016-11-02" version="1">MSRPKDKKPGLKAHLKRKREPEESADVDDKPATRPLLQAKRAKRSQSIQQLAEQPASDAEPKHQPAHNSETAKQSHKAASAKTAKSPREHPSAQDAVGDPALLADRLAKYIQKYCPNSSPIELEEQYLPAKAFLDTTGYDRDRVAANLPQFIERFSPEGKTGLSTCDEKASPHTLVVTSSGIRTADLYRELRVFQNAETKVGKLIAKHMKLRDNIEYMLGNKIGIAISTPFRFKQLVDADALKTEKLRRIVVDGSYCDEKNNTIFMMAQTFNPLVTLLNEKSIRQRYGDGKDNIEILVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C644</accession>
    <name>A0A1C1C644_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative FHA domain protein SNIP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_11192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT43980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C644"/>
    <dbReference type="STRING" id="86049.A0A1C1C644"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11192"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02064"/>
    <dbReference type="eggNOG" id="KOG1882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000038">
        <property type="entry name" value="FHA domain-containing protein SNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="120"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT43980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="213" mass="24377" checksum="4E8A9A6742997525" modified="2016-11-02" version="1">MSRSRSPRRREPRREQRRSRSPERRRSRSPRTKRPLPSQVDAFKGTSGSPAPQKQKPNWRPSGLLAAASNTVSTSAGAVVLKYHEPPEARKPASSKPWRLYVFKGEDILDELDLYLQSCWLFGREVSVCDYALEHPSCSKQHAVIQFRYIEKRNEFGDKVGKVKPYVIDLESANGTTVNNEKVPEGRYVELRDKDVIKFGHSTREYVLQLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C687</accession>
    <name>A0A1C1C687_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase, zinc-binding dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_00105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000022">
        <property type="protein sequence ID" value="OCT44054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C687"/>
    <dbReference type="STRING" id="86049.A0A1C1C687"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00105"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06334"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="85"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="453" mass="49845" checksum="FB82D05210AA487A" modified="2016-11-02" version="1">MSAIQQHDRSGVHRPRLKRVRAHFRRAMGIPKRWASYDGRVPSDSMNGESKQGIESIVAVSELTCPTPLDSTPSVQRALVVAQTGVYELRDTHAVPELENDTEVLIQARAVGLNPIDWKSVAYNFCLPSFPWITGREMAGVVERVGSQVSHVKPGDRVWTSTYYRDVRAGCFQEYIVVPRHTVLPIPADLSFEEAACLGVAALTASMALWKWLSVPMPKVKAWNRGSGRQNPQHSSGDSGYQSSLSRSSLLDGTQVPEEAAQEEWILIWGGSTVTGQFATQIARLAGLKPITVCSSRTAKLSEERGAEHVVIRDDREPSALVEEISRVTKGRITRALDLVGPSTARLCLHACSTPSQRETFGDRKILFAPLAMMKDTDEVPDNVTVEVVEMKHFVLDSESALYGQTLNDLIENKMLQLPPLEILDGGLDAVEAGLEMVRQGDRGGRKVVITVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6N2</accession>
    <name>A0A1C1C6N2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative beta-Fructufuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MgSUC1</name>
        <name evidence="7" type="ORF">CLCR_00607</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6N2"/>
    <dbReference type="STRING" id="86049.A0A1C1C6N2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00607"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01048"/>
    <dbReference type="eggNOG" id="KOG0228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="5">
        <location>
            <begin position="20"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="6">
        <location>
            <begin position="425"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="585" mass="65246" checksum="58C91D3EA4F6466D" modified="2016-11-02" version="1">MDPKNLSPDGDFLRWRPQYHLQPPAGWINDPCGLGYDPNTSLYHVAYQWNPESAHWKSISWGNARSRDLCSWEVSGTPSITPDSDGGSEGVFTGYLRPTNVDGQADGVLTILYTSAQRLPLHYTLSYVRGSERIHMATSSDDGKSWTPYTGNPIVPEPPPDMEVIGWRDPYVAEWHSMDRALGREPGKRLYGLVSGGIRDKGPAAFLYAIAKDALNSWEYLGSLCGQGINYTPSSWTGDYGVNWEVGNFLSLTDKSATPHDYLIMSVEGCLSEQGTPHNAQMWMHASIRIDEGKPTMTFDYGGRLDHGRRYYAANSFWDPISQHHVVFGWLQEHDLPEIWHDRQRWSGMLSLPRVVKHSEIHSVCGTLATPLGKITSIGKTEDPQGTYTISTLASAPHPVLEKLRGNLLPFPTPAKKHATAMFARPTKHLEVDVSCLLAQGTRRVGLSILHSSDAKQRTTMYFDAAAETFVIDRSHSTTVADVNTTPETAPHTLFRFRDPSGTVTQERLDVRAFYDVSALEVFVNERTAVATRIYPNRATCFGVEVFLDAESDSQSQRDSDAEGGEVAWRRSQCWEIRPQLVGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6P9</accession>
    <name>A0A1C1C6P9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6P9"/>
    <dbReference type="STRING" id="86049.A0A1C1C6P9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00626"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01139"/>
    <dbReference type="eggNOG" id="ENOG502QSMW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5977668at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3110.10">
        <property type="entry name" value="protoporphyrinogen ix oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.20">
        <property type="entry name" value="Protoporphyrinogen oxidase, mitochondrial, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF17">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="511" mass="57428" checksum="DFE157AA78590DFF" modified="2016-11-02" version="1">MGKRVAIVGSGCSGLGALWALRTSTDHEVHMFEAASHLGGHTNTVTYEALDGQKVMVDTGFTVMNTATYPNFIRFLKALGIPARRTEMTFAVSRDQGTFEWSGTSISSIFAQKRNIFNPGMWRLVFDVIRFNEFALDLLQDQPESEQVPARDRAKTSSKPSSEETIGEYLDREHYSQEFRDNYLIPMTAALWSTSPDKCTSEFPATTLVRFLHSHHLLRTNATRPDWLTIPGGSKQYVDAVMKHFPRGQVHLKSNVTALTPTKRGSVILTANERDYVFDHVILATHGDQALKILRPIASTQEAEILSGFRTNRTVAVLHSDISLMPKRKVAWSAWNYITESPFPPLRSQTVSKVCLTYWMNLLQHIPDSKFGPVLVTLNPLNMPDPRLAQGIWEYSHPLYNAAAIRSQRLLPKIQNIRGISYCGAWTKHGSHEDGFSSGLSVATNHLGAKLPFEFIDSDVLRGERPTLTMKNYLLRLIILLVQIALLLVERVWHAGTGLLDRRTAMPRKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6V8</accession>
    <name>A0A1C1C6V8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6V8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05938"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06968"/>
    <dbReference type="OrthoDB" id="10661070at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT44273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="415" mass="44466" checksum="759B5D0ACE31679C" modified="2016-11-02" version="1">MAWLGVLIAVTKEMLDIVEAGGPFGPATRLRELLCIVNPRDAELELVPDGVLDKLFEGAEVVKLVEVGNTKIGPPVEPLPLLELRMSDALVDTAIKPEVTSSRKLKDKDDVVSVFVVSEDELVALTTVVVDGGIGLPAEVKEELIGMEEVLIINIVLPLVVDSGSRPSVTLELPDKVVDVWLLALLETPAELVDAAVGPPFTLEGLVALNVDVLARLELMGPDGEVDGKAVEGPDGFDVGEEFGPEVDVDSPLGVLEVGTGDELPGWFKLEVEIVVKPAIEVLDMLELEREVPEAPKVELGLGPSDAFELAIDGDLVRELRERIALGVNVEPGFSPPALFEVVEVVVKVLLADEFWRLLVAVVDAGTEVSSVAVVVERLVEVNLVPVWPLPGPYVVLERSVDVTMIVLVISRSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C747</accession>
    <name>A0A1C1C747_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress responsive A/B barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C747"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06414"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07049"/>
    <dbReference type="eggNOG" id="ENOG502STNI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3830014at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="110" mass="12606" checksum="5B37C5FFBC789AF4" modified="2016-11-02" version="1">MSSKTVKRITLFKIPKEEDIDGALAQYEILRSTAQKDGKPYIISNEATRVTNSSDERAQGYTMLAVTVFKSREDFDYYDKECAAHKKLREFITPRRTGFATIQYESELGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C755</accession>
    <name>A0A1C1C755_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GPX2</name>
        <name evidence="9" type="ORF">CLCR_06369</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C755"/>
    <dbReference type="STRING" id="86049.A0A1C1C755"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06369"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06987"/>
    <dbReference type="eggNOG" id="KOG1651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061692">
        <property type="term" value="P:cellular detoxification of hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="170" mass="19335" checksum="697812110C802AA5" modified="2016-11-02" version="1">MASATSFFEFTPKDKRAQEYPLSQHKGKVILAVNTASKCGFTPQFKGLEELWKKISQKYPDQFVILGFPCNQFGNQDPGSDDQIQEFCQLNYGVTFPVLGKTDVNGNKAEPVWEWMKSQKPGLLGLKRIKWNFEKFLIDRDGKVVQRWGSVTKPESLEKDIVALLEKKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C770</accession>
    <name>A0A1C1C770_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_11206</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C770"/>
    <dbReference type="STRING" id="86049.A0A1C1C770"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11206"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07033"/>
    <dbReference type="eggNOG" id="KOG1335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43014">
        <property type="entry name" value="MERCURIC REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43014:SF2">
        <property type="entry name" value="MERCURIC REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="11"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="9">
        <location>
            <begin position="380"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="7">
        <location>
            <begin position="47"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT44336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="495" mass="52752" checksum="E8A836AC5D40A4F7" modified="2016-11-02" version="1">MSMTTTTSHYEAVVIGSGQGGGPLAQAFANAGRRTALIESKHVGGTCVNEGCTPTKTMVASARIAHLACRAQGYGVQFKRSSLTLNMETVRKRKRDIVDSFRAGSETRIKATENLDLIMGKATFRGPKTVEVLLNEPLPRHESDGGSGSGSGSGMDTTLTITGDMVFVNAGCSPSKLDVKNACRTEGLLDSTSIMELGDVPRHIVIIGGGVIGCEFAQMMRRFGAKVSLVQRAAQLLPREDADVAAEVCRIFVDGGIDVYLGATTNEVSNVTLGQIVVSVTQSDGNPKSILCSHVLAAAGRTPNTADLGLESAGVDLDRHGFIKVDEHLATSAPGVYALGDIKGGMQQTHVSYDDMRLLRRNLITHAQSGERASVQGRLVPYTTFIDPQLGRVGMTEKEARALVPPRNVKVAKMPMAYVARALEMDETNGFMKAVVDADTKEILGFACLGVEGGEIMSVVQMAMIGGLTYDELENAIFAHPCLSESLNNLWVFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7F0</accession>
    <name>A0A1C1C7F0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7F0"/>
    <dbReference type="STRING" id="86049.A0A1C1C7F0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06233"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07100"/>
    <dbReference type="eggNOG" id="ENOG502S5WH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT44407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="210" mass="21875" checksum="C25715C5A65382B4" modified="2016-11-02" version="1">MPETQIVPRAGVREDIFWKPFVPSLYVGAAAGACGAAYGSIAGTLIQTSSPLAYTSLAAAQWFTTGTTFFYCRSLLLSGPFSKDKSLHKVAASGIAGSCSGAVAATFLPRGSVVTGSIMLGVIAAVSQTGLNAMQGSVPFSGVASGFRKKMAALSPMKSLSDQEYEQLLLDKLLKVDVEIAILDDQIAGLRAAKLQHSPNQQDSLRDGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7F3</accession>
    <name>A0A1C1C7F3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_05484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7F3"/>
    <dbReference type="STRING" id="86049.A0A1C1C7F3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05484"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07092"/>
    <dbReference type="eggNOG" id="ENOG502QZSN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3989227at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF79">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="726"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="788" mass="87509" checksum="DAF90DE29BA94A24" modified="2016-11-02" version="1">MSRPRASHACRECRRKKLRCDLARPSCTRCASSGSPCVYGAGSSGSRDFQFVQTTFHGSRGESSGAGSLAATEEVALSPARLRTLEEKLENLTAQVQALQGRNSTPPLIAAASEPSADVANDTMKRVRTTESAASAEVMRESGAGHLLVQPGGRLRYVSRGHWAAMCEEAGEIEMLLRGQTRYDLPVAEKQTRPLHDGEVVSAPAAWDRSKRVSSHSRQSSPLHTLQILDRSRADALFDAYISCFHPVVPLTHIPTLRRDYELVWDLQRSGGAPNTIQTMPLILAALYAGAVVYHHPSLQNTRPDTDIERVATEIHHEATAALHLAHFPRVPTVAGLAAHLILQGMWMRDEEPLSASGDFGVAVRVAQMLGLHKDPSRFKTTVAPIQAEIQRRVWWHVFHCDVLVAVASGLPPLIERSSWDTMMVSDLYEDRFGTMEGLQHDEESRARYLQGETGPDASPLASPLGIWLQGKFQDALLVRKLLDKAFHEDQMTIDDMVSARIDLQLLRRQLRARSQLIPINSSNNTYEDNPQFNMWAKVLLTTLGDKNWWFLHTPLLHRSITQAWQSLIPNLQLYCCAFLEQYIILCCAQDFIRFHWSWPGNHQPLHALMLVLKEVERNPTGAEVEISCTVIDQTMALCAPEGGITASGNGAMMHRPLNEGGAEAWDLIRRLRARVWTKIGRDPDVILTRDDVESIVAQKLQAFKASSGILDLRTPLPSEVTGQFEQQPMAQPATSLHSGTSSFTTPLPDVAGDPSQFDQYTFGLSGGRPTPNINWDDWDQVFNTGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7S0</accession>
    <name>A0A1C1C7S0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7S0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06453"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07191"/>
    <dbReference type="eggNOG" id="ENOG502SBW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="110" mass="12132" checksum="8BC04BBC34F71023" modified="2016-11-02" version="1">MKLVSIANFPVARRGLLRQALGQARLASTTTKSEQSEPGVEPQDPSNSAKKKEAMDKLKKTHKSMAELDEEMKLAMESMSGEGGEYGLELEGGKPVAMKRSVKDNMFRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8N3</accession>
    <name>A0A1C1C8N3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureD</name>
        <name evidence="3" type="ORF">CLCR_06106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8N3"/>
    <dbReference type="STRING" id="86049.A0A1C1C8N3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06106"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07538"/>
    <dbReference type="eggNOG" id="ENOG502QSQN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5550464at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="328" mass="35909" checksum="E904085AD7924666" modified="2016-11-02" version="1">MSLPISPFAASSAAAGTGEIILALLPPGRQALQKCTYQYPLKLIAPDPHHSSEQKHVTIVFLLTYGGGLVGGDQIDLKAELQDGTRLVLLTQGSTKIFKSPEKSVVSGQTLNVTIGAQAALCYLPDPTQPFAESVYDQKQTFTVQPDGTSSLLVLDWVSEGRRARGESWTLWNWKGKNEVREFNDHGKGRLLLRDAVMLCGDDLGGMGLVEKSNKMGIFGTLIVYGPIFKKLGEFLLREFSTQPRIGAKNWTTGDGTAQVNIVRENDQAKQIEQQNGLLWTAANVRGFVLVKFGAKEIDGARRWLGTLLRQEGSVEKVFGHQALLCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C951</accession>
    <name>A0A1C1C951_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C951"/>
    <dbReference type="STRING" id="86049.A0A1C1C951"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06354"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07690"/>
    <dbReference type="eggNOG" id="ENOG502SD1I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5419752at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="5"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="183" mass="19068" checksum="2FEB2282C238FCA0" modified="2016-11-02" version="1">MPYFSDLNIYLHQSSLLIQAYPTTRITTKYSLPHKPNSKAKSKPSLDASKGTDSAPETSTQAQAQSQAQPKRDRSATLTLKTYHPESGICLKYRTDKAAEVGRLLTGLGRLARGDTIEPPSAASAPAAGTATATTDGDADKMEVDGVAVKMEDKVATAPPVAVTPQAGGGGGGGKAKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9P6</accession>
    <name>A0A1C1C9P6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_06142</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9P6"/>
    <dbReference type="STRING" id="86049.A0A1C1C9P6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06142"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07822"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT45162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="251" mass="27823" checksum="CE3BB1A2A92D14F1" modified="2016-11-02" version="1">MSVWVGSSNNYAYLVSDDETKDAVIIDPANPPEVLPVLEEKSKSLKLTAIINTHHHWDHAGGNKKILDAFPNIRVIAGKDSEAVSKTPSHGSTFSIGKNIQVTALHTPCHTQDSICWYMEDKATDDRVVFTGDTLFIGGCGKFFEGNGTEMNKALNEILAALPDDTKVFPGHEYTKSNVKFLKKVDGENEAVQRLEKFADENKETQGKFTIGQEKAHNAFMRTSSEKMRKVTGKNEPHEVMAVLREMKNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9Q4</accession>
    <name>A0A1C1C9Q4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9Q4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05453"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07914"/>
    <dbReference type="eggNOG" id="ENOG502SDIM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="800"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="738"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="800"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="851"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="885" mass="100416" checksum="EB56B930BDC61D32" modified="2016-11-02" version="1">MRGLWTQASRPRLTAVSHHLSCVDSFSSTLVRKTTTRPPRRRPSFAEHVFTLLLTPVLAAALFVDTSWKAKQRRDWDDKLAAINHEISQLREQEQRLRSSLQLRDIHYGLYQQRRSYATAAYAQVEVEDEQILSEIEMPTWEEGVSVEDEVPADQNPRIREVLSAKEFSHEQLSNFHRYHRLNAITLALRMLLHLRIGPNPFYSITPEDDPVDIAALDSLDPSSSVSLPTDTDRLVQMLALTRKQMRSLRKLDDLFYAAPQIQAQANRGALHRTIQDLTVEFDAGNVSLPGLIEGYGKAILRSKEVPSISVYVMLIRSLSKVGSYSLAYHAAAAMKNSTLPLSDPAIFYMLLQIGRACDSRSLNNLLHYIANSDNPLNLIHKWEKARVHGLDLPVPATLNPRLLMALVYVALRCEQPDRAEAWLSLLREADYGSPWKDDLFRSFLAYHSQHGNWEEGKKWIQRSVNHALSIANQSIDRLARVIYRMLDLCVRCRKLAEYTAILDAAVESGIGPPPVQKSQNDYRKFHPRTRSILLEWEALPLPDNTEACPVIDKAKSFQYACRSLLEQLAQTPPARATKREGDADEDLILMASTASNPNQRYAVRRREQDSVHSNNASALVPAEVEKLQSKLAEQDVLISEMKARLDLALLRQNSHEKEAAGRQERWIQSAARVAQEVRETKEGFEKLQGRFEAQEAIILQLKVRSALAASRQQSWLEDDNERSQKWTESTVQMTEQLEQLKDGFQKLQRLNEMYEQERAQTRQEIAELKAAARLVNQESQRCQDQGPATGTVHRMLRGDASARSEMAKKQESSKPIDVPTTKTVSRENGPLLSSSKAIRQALKAQKKKTPMSQPQESSGMDMNDLPADEDTLRRTATTPKKRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9V5</accession>
    <name>A0A1C1C9V5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter STL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">STL1</name>
        <name evidence="11" type="ORF">CLCR_05590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9V5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05590"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07900"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="21"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT45248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="508" mass="56098" checksum="8361B2728E2BC165" modified="2016-11-02" version="1">MSAFNRGYAQSLNGFWLQAGITLCSAWAFTLFGYDQGVLGGLIALPNFLSANHIDPQAADLQGTIVAIYDIGCLTGCIVCGFVGQMLGRRLFIVIGGALVCFGAGLQAGAHGTAYLISGRVIAGLGMGLNTTMVPIWVAETSKAKTRGALIATQLSIVILGLTIAYWFDYGMIRNHPNTEAVWRLPIAFQVVFILLTFATIFFLPESPRYLYAQGHIDDADHVMARIYSVPVDSAEVAKQRSDVFTALEAEKEYNFTIKNLFYDNSPVNTTWRLWLGVLVQFFQQMDGNNIVSYYATYLFINSLGMSQNQAAITSGGVTLLFLGGTCSTIYTMEKFGRRTVMLWGAVFCSLFMILFTIGLGVNNDSSNKLAVVSIFLFEFCFGASWCDAPWIYVPEIAPLHVRHIGTSMGVFTQWIITFIVVKFGPMGIQSSGWKFYLLFCVFNVLAIPFVYFCVRETKGLSLEEIDLLFAKKEYRHVLQARLRGDPEGAEKGGVDEQEVALETVEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAE5</accession>
    <name>A0A1C1CAE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Levodione reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lvr</name>
        <name evidence="3" type="ORF">CLCR_06070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAE5"/>
    <dbReference type="STRING" id="86049.A0A1C1CAE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06070"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08065"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42820">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42820:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="301" mass="32843" checksum="673155B92D826A28" modified="2016-11-02" version="1">MKRFSKFWTRPAAETTRQLSERQKETNPQRHQKALHSVDKVFERTVVLITGAGSGIGQECARQFALHGCRKLFLVDISLPGLQQTREMVGKDQPHVQVELYQGNVAEESSVKRMVSQCIEIYGRLDVACNNAGISGGSARTSDLAVEDFDRLCSVNQLGVFLCEKYELRQMLQQDRSAGDQRGAIINVSSIAGNCIIPTTPAYAASKHAVVSLSRCDALKYAQDGIRVNCVSPSAVWTPMVSDAGLPQEFLDMGAAQSPVKRYLQPLEVADAILFIAGPKATAIIGANLPVDCGTQLLRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAK3</accession>
    <name>A0A1C1CAK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="8">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_01502</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAK3"/>
    <dbReference type="STRING" id="86049.A0A1C1CAK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01502"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03464"/>
    <dbReference type="eggNOG" id="KOG2587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit RPC82-related helix-turn-helix" evidence="11">
        <location>
            <begin position="6"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III Rpc82 C -terminal" evidence="10">
        <location>
            <begin position="143"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="12">
        <location>
            <begin position="375"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT45554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="533" mass="60335" checksum="1FC22CE17EFD564C" modified="2016-11-02" version="1">MEEFAKLCCHIVEDYYGSFLAQIFRQLAQLGRLSIQQLAQKCRLPLRQVKVGVGTLIQLRLVYHHTTYEGLSTYQADTTYAYNIMRTGRLVELVEWSLGASAAGIMETLAAMGFATAHELEAEVLEKSDPTHPMGKSRFQTLLKQLVSSGYIKAVREAHFQSPSDRRQDVERSLRDNGLIPTGTGKKIAADAESRIDSELERRVNSSVSAYDVSQELTRSPTQDNTTLSVDYSNLIIRIRNDRVAGMAEKVFGKQIAQVARAACSQITDVDPRSLPVRLVENPANAVQRLDAAKLCSGVFHGKANGGGRPNGTNGHHSDQPNGATGEDRIIEHHLAVLAEGNFTFLLQEPNNSKSWSINKRKFTNFLRDKEIYRLIGESMTEPALRVVRMLADKGKLDERTMLDIGLLNAKELRKCLSALQTMGFLELQEVPKDPQRQPKNTIFLYFHDAERVQKVFLDKLYKTMSRMYERLHLERDKVASTLSKVERLEDGTEVEILPAAELQELYRWRQKESWFTTEIHRIDESIAILRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAS9</accession>
    <name>A0A1C1CAS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01764"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="97" mass="11235" checksum="1199B178C4818691" modified="2016-11-02" version="1">MVHACHGAFLVSSYGQSKEEEEEEEEEEEEEEAEKTKGKDITSRFGYMGVESQPIAVQSVDRRLEDRPTQGLHAMAAEVCLLEGGAIWRRRRRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBY4</accession>
    <name>A0A1C1CBY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00465"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09997"/>
    <dbReference type="eggNOG" id="ENOG502SHBW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF10">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="37636" checksum="7DB4E89AB97A0707" modified="2016-11-02" version="1">MADYSNLPDFDSLPKVEGMPQGCAWGSFDKGGKKDHLGCLNLLTPQVIQEAFKEARDGVSVSLNWPIGAIKKPGFARKGLEHKVLSFKEGPFNLHGFDDELEFNTQCSSQWDSLVHYAHQPTGLSYNGVKPTRDQLVQEFGNVDLDKALPTLNHWHDRGGLVGRGVLLDYRAYAQAKGITYDCFSSHAISVQDLEAVAKHQGTELRPGDILIVRSGFTEDLGAATAEEQERLLGTHKAVGVKGVRESAKWVWNHHFAAVAGDAIAFEQLPPIVEDEGNREGGIAELVLHQYFLSLFGLPIGELWDLKALGEHCKKIGRYSFLLTSVPLNVPGGIGSPPNALAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC33</accession>
    <name>A0A1C1CC33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_00452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC33"/>
    <dbReference type="STRING" id="86049.A0A1C1CC33"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00452"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09975"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF172">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT46041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="442" mass="48825" checksum="AA98A2F8AA20ED4B" modified="2016-11-02" version="1">MLEGWRSLNIAVIGGGIGGLAAATSLRRAGHQVTVYEQAHYAGEVGASISCAANGTRWLEEWNVNISLGKTVVLQKLIRHDWKTGDVIAEYDLSDYKDQWGWVYNMFHRVNMHEMLMDAATGQGEGPPARLRLDHKCRSINHDRGIVTFDNGVTAHHDMIVGADGIGSTVRRTLGIIPTRKQSSSTCYHCVIDSEEVKRLGLLDLTPHCAIEFWGGVGIEKIVYSPCRAGEINSFYCFFPTEKSDHATEGWNHEASVDQLLAPFPDLDPRLLALFKHARDIGPWRLFVHEPYTHWTAGRTCLLGDAAHPMLPDQSQGACQAIEDAAALGLIFSRQYTYTADVAAGLRLYEQIRKPRATKVQAASARARENINERIGFSSQGIGYKAAVASGKLTIDEMNLYDMRRHVASEAAPERTNDANGESTYVPLVTTMSNMPEIAARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC93</accession>
    <name>A0A1C1CC93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative intracellular protein transport protein (Sat1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC93"/>
    <dbReference type="STRING" id="86049.A0A1C1CC93"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01089"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09361"/>
    <dbReference type="eggNOG" id="KOG4469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="764" mass="83178" checksum="1C6AC6B3E57B2B29" modified="2016-11-02" version="1">MHSDIHVAVRFHDQSVFAGEQLHCTITFRNVANLAEEPLPPSSQSRRRGRRESISQLAVQANRPNNGQRLGQYGRSNNNEHSPDQAGHHRPSTLVNNRDSISSTRSQRPAHKHQRSVSIISVASPTVAEDGGSLTVGGWERQKRPGHSRSSTVQILHTPQRKASQPERKDVRNSLQLPRRSGRRSPLSPVASEGRDTSSQSRSRIPSDHSRGRPAFQEPDELRISSPAETTDDAPASVSGPGPELASERSSADFYSLSNHSQETLMSEQPSIISDHPPPWTYSAPVARRPAIHQSQKPQAVNLLMGYAQLSATFTLDASLVDQSHFEEVKTKGFLGGQAGGGVVGVKKPRPNSGFLGGFNLNSIGGSLNNLIGGDNMSSVKEMNAVTNSRAIPLLSTPQSLLFVDMHLEPGEEQSYSYSYPLPRGLPSSHRGKAIKISYNLTIGVQGLPGSRDVHTVRQVNVPIRVFPGVSHDGEIYGHDLMQPHVILRDLAHTKSILAAEGQDEIATSTTHGDERPTAEFLTFVDTLLDRNRRRQSSTGTMDAFSNSQDMGSRGKTLQAVDRAIVYSNSLSEGDSSANRFEIARTGQRVAVIVIDRPLHRLGETITAVVDFSESEIAGSSLKATLETSEKVTPALAVRSVATINRITRKIYGARSENILFSKRATFAFSIPASATPTFVTSGVNLDWSLRFEFGTIKPFESEEGGIQPVPDLLEEVVNDERSTVNVAVENLECETFEVVIPITVYGDLVPDGKEGEEIVGIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCU5</accession>
    <name>A0A1C1CCU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ARID-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_11243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCU5"/>
    <dbReference type="STRING" id="86049.A0A1C1CCU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11243"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09184"/>
    <dbReference type="eggNOG" id="ENOG502QVTM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="9"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="622"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT46343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="922" mass="105495" checksum="8FA9B218E943F594" modified="2016-11-02" version="1">MAEPPRKIIEDEEEFINDVAAFHEKRGTTFDRDAKVSGRPISLHKLYKLVMERGGYDAVSAERMQWRSLVSKFGFGKTHEAVMTFQLKTVYYRNLAAYEIATYWGEEPPPKEILEDISARGGDLRKRTLDNYAVGNLRHTVDGSMGDGAGESQEEEQLTPKREKMESEEPGSASRYPTRQLRQDPKRTQIFQPDTGPSRTRTVRATDSPSVPPPTQPIYTSASVDPRSSGFDWFDKYEPRQPVALTLRQVQTPGNDPLYYPRKAQAKAMAMPRVPPEPQQFLRQAIPAGMTGPNIYLRCLYGLRSGVQEEQDFALHHLVKVSYERGDKYKFEGFPFLAESLLEKALEITQLIYGVKWEISYDEDDEGQPVNTLNAALGTSNLLERIRTAAPEVTEKELETADFATRLEKMKEAVLVLRNMVILEENALFMSRFPLFKDFLTVAASLPHQPRIAEYKQSALEITEQVTRYWSLKPRDPLYLSLLPYLESEDRSMLISALRSINRIALDTPDVHRLTDVPLSTIERLFSLTLLDDNELLETTLDFLYAYTAIPENNTELLSTVFHLLPNLITRLTSLLLYQSIKQEEKVLSQPTPRSQTAPASIPIVPPEVHAHLMQFVEPERSSRWLRCCFEESLVDDITQIAIWQAYQGKFAQNNPIPAAEFIKNVSNTFVAAQAQVINGPTPRFIIKGIKPRRVAVDVQGRPLFRCMWDMTQPNVQDPSGRVNPRNICPVWQTKRERLWEHIMTEHLKIEKTPDGRFHPKGCEDWICRWTHCGRRSPITKTSEIGPHMRMHIPQTAVEQSKLIHELANDVKDSDPIHMKHEWHYTAMDATNHPCGIPWMSVMILRNVARYANKHGQPFEKDGVRLNERLFGAHKYSLFHVLSVSRTLRDYVNDLLKMIDVAGIGEEKRGVKREHGDEGDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD40</accession>
    <name>A0A1C1CD40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PMR1</name>
        <name evidence="16" type="ORF">CLCR_01058</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD40"/>
    <dbReference type="STRING" id="86049.A0A1C1CD40"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01058"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09094"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140613">
        <property type="term" value="F:P-type manganese transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000040">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="354"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="814"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="34"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT46433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1048" mass="113517" checksum="09A291B93B587D5F" modified="2016-11-02" version="1">MSSLLPVFNAEPQANRPRSPTPHYASTSSSITSSYSLLTPQQTAERLQTSTTQGLLQTEAHARLAKDGPNELPHEEEEPLWLRFLKQFKETLILLLLASAAISLFIGNKDDAVSIALAVTIVVTVGFVQEYRSEKSLEALNKLVPHFAHVRRSVPRHTTRSLASENGAIEMEPLGNGSAIPPEEKTSTTIPASRLVPGDLVIFSTGDRIPADIRITHSAELTIDESNLTGENEPVEKHAAALERNKAHHEHHGTPEPYNAAGTVGADVRLNEQHNIAFMGTLVRSGHGEGIVIATGGNTEFGTISLSLQEIEAPRTPLQQSMDLLGKQLSYMSFVVIGVIIIIGLMQGKQLLDLFTIGVSLAVAAIPEGLPIIVTVTLALGVLRMAKRGAIVRKLPSVETLGSVNVVCSDKTGTLTLNHMTVTKLWHFDISKPAPVDPTAELTTATKTILRIGNIANNGRLAQNASGTPATAASAAVLSSTRDRSSTVTKSRWLGQPTDIAMLDLMDAYGEDDIREQIGPRTSETPFSSERKWMGVVIGSALGEVTNGYGLGSETAYIKGSIEQILSRSDTYLTKDGREVVLDERGRKEVHAAAQAMAEEGLRVIAFASGVLRNQARQGSRSSTPGLGAKKPSEPQTDAFTGLCFAGLVGMNDPPRKDVNRSIRRLMNGGVKVIMITGDAETTAVAIAKSLGMPINPASSSSRSVLRGDELDRMSEQELSEAIVKTTIFARTSPDHKMKIIRALQARGDVVAMTGDGVNDAPALKKADIGIAMGMLGTDVAKEAADMILTDDDFSTILRAIEQGKGIFFNIQNFITFQLSTSVAALSLVLLSTMFGFKNPLNAMQILWINILMDGPPAQSLGVEPVDPRVMTQPPRPRNANVLTKRLIRRVLTSASIIMMGTLFIYLREMVDIDDPNVDPTLINSTPLRVRTVTKRDTTMTFTTFVLFDMFNALTCRSETKSVLFGEIKLFGNKMFNYAVAGSLAGQLCVIYLPFLQRVFQTEALSPWDLFSLVCMTSTVWLADEVRKWAERRRSSGRLPSVGYSANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEH5</accession>
    <name>A0A1C1CEH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02331"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02478"/>
    <dbReference type="eggNOG" id="ENOG502SP3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5422688at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="647" mass="71276" checksum="FE8E865E861FB438" modified="2016-11-02" version="1">MASSVDTAAPEGPLWAPWHVLRHWSPFNIDALGLVTLLGAEEINAAVGRLVASAYLEYLPLLGAYVIAGDRFTEKSAGWNLYNISQGIHTTDLAAWLTRWMLSQNFETTRNYVVWTVTPPRSRKNDIIVSVLIGFVLNGFLVALTILSADWYGFANALAMIVSVIVRVYVIGQQRLAMDAMIDKAVANFGPPTGDSYEARRYEYKTWKHKHIGRKSGGLRLRKPDPPTTIGGNQSSHSDSSSPTNGHKQAVHQVQVVAAHQRPNPKGKYGKVWEGKPIKVLIIQSDSKAVTFEMPNELVIPPSLFIEGPIILNPRTYFVMRSIGWLAFAVHIVAIGMADLATQIYTVLLIVLPTLLLIKKTGCDDSEWVNTFTGWKSAILHSHGQASKPDGNQSAAEKADAKKFRKIRECWIGSRLKAEVYEWPEAYEFHEEVNGNAKKWVSGGPPPGEDRSKKRQDLYAWLALTRDEEESMDKWDLFPHIRSGNNSWWETYKKKKHALKEGRDAMGPQYVESRTVRPQSSQDDYTKPFKKPNRLATEVILGVSDGATSAPQPQLPAQAPNPSSPPHAPAPQPHHTDSVTTTSSAFPASSDAAGAQPAIHNNATVSSIEASLPRVNTQPSTTGSAQIDPSTTMTQSPTTVEATDEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEL7</accession>
    <name>A0A1C1CEL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">RPS0</name>
        <name evidence="9" type="ORF">CLCR_02553</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEL7"/>
    <dbReference type="STRING" id="86049.A0A1C1CEL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02553"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02479"/>
    <dbReference type="eggNOG" id="KOG0830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT46939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="286" mass="31107" checksum="EAE9A89F8A454881" modified="2016-11-02" version="1">MASPANLPSIFNPTSQDIEMLLAAQCHLGSKNLQVHMEPYLWKTRPDGINVINISKTWEKIVFAARIIAAIDNPADICVISARPYGQRAVLKFAAHTGAVAIAGRFTPGNFTNYITRSFKEPRLIIVTDPRTDAQAIKEASYVNIPVIALCDTDSPTEFVDVAIPTNNKGRHAIGLIWWLLAREVLRLRGTLPNREVEWDVVVDLYFYRDPEAEEQKDEEKVPGVEEAGPAAVDRGFTDNADWTGEPGTAPGIEGAPQADATWNDPGTGGGDWAQETTGAGAAAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEL8</accession>
    <name>A0A1C1CEL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_02258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEL8"/>
    <dbReference type="STRING" id="86049.A0A1C1CEL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02258"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02445"/>
    <dbReference type="eggNOG" id="KOG2519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041177">
        <property type="entry name" value="GEN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18380">
        <property type="entry name" value="GEN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="111"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="610"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="616"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="855" mass="94712" checksum="E62172880D716F8C" modified="2016-11-02" version="1">MGIPGLFKEIGKGERIALSRLCITHLEKHNRPLRIAIDAAIWSFQTQHGGVGGKNPALRTLFYRLVKLLALPIDPVFVYDGNKKPLCKRGRTVSRWHGGNVSDHASKKLISLLSFPCHVAPGEAEAECAMLQKHGIVDAVMTQDVDAIMFGSGLTLRDWSKEGNMKGNQTPTHVSVFDLEKLKEVSRGLDPDGMILVALLSGGDYDGDGVAGIGVSLACDIARAGFGSDLLELVKNGDDDGIAEWRERLQYELESNESGYFKKKRKSVKIPEDFPNRRILDYYMNPAVTEERELRDLEKKWAKAWEAEVEVQALRDYARDTLDWQYKPGAWKFVRVMAPALLADRLRRDAAASIVTSPDQITERRQHFVSDGIPELRVTVIPAKVVGLDLDMEEDSPEYLSRLAAHGDDEALGEETELGGDGAPPSSQIPAERRRAPPWLPWNPEKMWLAEAIVELGAREHVERWNQMQWEIQNDPKKFATRKCPQKKKEPQKPKKTGGMKAGAIHSYITATKPTSKPGDSGQPGSDAAAKMISDPLAVVEASLLLSPPRAKSTATDLFAAEDGSLSPSPPAPRVEANIKTRRAIDTPTISKAIRQEQSTSPFMQDYFKSTKRSDVQQASQEPQTSQVSPLTRLNRVDLRKEEDLLISQETHGEKHSRPSTSSSIDLVVRIGKKSSKPRVNTLPVVSLEPKSSYSHQRGVTASDVLLSQQERFEAANPEKSDVEDTLNNVTRRTPKRRAKRDQALFDIQASSPGTVAPRRRIESFFKPYLKPRKEEEALPIETGAKDSEDLVVFPPEPTVDLLRLSGDAHMHAIPRSSLPGTWKEVECESGPSSQTVLPSATRLPRVSIVDLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEN0</accession>
    <name>A0A1C1CEN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine-protein kinase ATG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Serine/threonine-protein kinase atg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ran1</name>
        <name evidence="12" type="ORF">CLCR_02455</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEN0"/>
    <dbReference type="STRING" id="86049.A0A1C1CEN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02455"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02513"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000549">
        <property type="entry name" value="Protein serine/threonine kinase (Ran1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="29"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="324"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT46907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="414" mass="45758" checksum="03233397C14F9AC3" modified="2016-11-02" version="1">MLLTPPPSPQLATSLAPEDRLGCVLAGRLELVSILGIGAYGVVYQAIDRLTNIPYAVKALPKAGLDPRQRRFQRREIALHNQASQHPNVVSLLRILESPDCTYVVIEFCPEGDLFSNITEHGRFVGDDQLAKHAFLQILDAVQYCHSIGIYHRDLKPENILVTNNGHTVKLADFGLATTDSVTSDFGCGSTFYMSPECQQTPTRSYARYAAAPNDVWSLGVILVNLTCGRNPWKKASADDSTFRAFLKDSKFLSSILPITPELNMILRRIFECDPHKRITLQELRDMIINCPRFTTNSYNTLPPSPPASPYAYVDSMDCANLALPPSPPASPSPHPPFQTQPSEWSLFEPTSKQGSSCSSLSTDSGYESETPFPDGGQCLQPPVFNFYGDVIPLNEHEKPYYTQPSFVPTVAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEW0</accession>
    <name>A0A1C1CEW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative homeobox and C2H2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_02278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEW0"/>
    <dbReference type="STRING" id="86049.A0A1C1CEW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02278"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02381"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="165"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="167"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="839" mass="92685" checksum="4C9120A696374380" modified="2016-11-02" version="1">MEYFDFEDASHAIPQLDLDELSSLTGEACEADATDCFDSLFFDKSAFLPATRPAPPTTVMLKLINNIEIEAIPHPSDISADYPMFRAKEPCELCAKMGLDCFLATRGAMVTGCTCCISLYRECSFVHPKIPRGFVNTFPGIAEDQQIPENALTERRRAMKSMEEGRGRKTGARFPRDAVKILKQWLAEHADHPYPNEREKDELKQLTGLKRSQISNWLANARRRGKVRPAESGPSSPMLGAIDIPQSQDGSGIADLNPLDRWKASPPEHEPASMTAIARAVTSTPLPVRNPSVSSLQGSRPSSRPSSRKASSEDDSSFSMFRAPSVSSFETRESSNSDLTFASSRSNRSKGSFASSQDRRRRRRAPVAQRAAAQQAKARAARIFQCTFCTDSFPAKYDWQRHEKSLHLALERWSCCPNGGTMTDALTGLELCVFCREPNPSTDHLESHNFNACQEKTVQERTFYRKDHLSQHLKLMHNAKVQSHMETWKSTTNELKSGCGFCPSKFTTWQQRADHLAAHFRNGADMAHWAGDWGFEPYVERLVENAIPPYLIGHERNTMEPYVARAMATPSSATEGGLTTGTSAESTEPDQITKDSNCWGRLEQELSKFVSQQRALGQIPSDKDLQDQARMIIYEDNDPWNWTCADNQQWLDTFKYSQGIGSTTGTTVASKSLAEVPILAPYVIKGGLKSKAATSQSHTRRNLSTDSTCDSFKATPDCGSMPNSAAVATFDNGMELDFDSIDFSNLDLGIVDEMNFDMEFDNNQGGGVASGMPVSTTPFSSSIPGDTLFGSYGVSPRTNMGMGMNAGMPLQQTKPPNSSPQLMSEQDLSQLTGYMSGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF07</accession>
    <name>A0A1C1CF07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF07"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02667"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02359"/>
    <dbReference type="eggNOG" id="ENOG502TG8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4161235at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="146" mass="14759" checksum="FCD620946AAF5612" modified="2016-11-02" version="1">MTTPNTTNSANLNNASNLQATAPPGQDATPDQSFGAAPSTTNYQSTSAGDKTSYTSSDPTTARGASSTSKIAGDLKGMAQGVAGSVQAAVGTTFGQKGMADKGFEKMSEEDARLAAKSGKLPVGTEQRSKVLEPGQVGRAETGNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF75</accession>
    <name>A0A1C1CF75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_11257</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF75"/>
    <dbReference type="STRING" id="86049.A0A1C1CF75"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11257"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02311"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="163438at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="81"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="672"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="811"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="844"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="905"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT47116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="925" mass="105407" checksum="A0A700D2EFA8FB93" modified="2016-11-02" version="1">MEPPGSKYSQRGKISRANVVFGDQKIYSDRSDSSYRNVIEAFGSECDYDQVHHEIKKPHDQTCSWSQHQQDIRSWADDNSSLMWLVGGPGIGKTVLAKYLIKSLQQDGDKGKRTIYFFCDRQKKKDGSKAVFILRSLIYQCMTIAEYLGKRHVKPRYDTYGPHLLKSNGELAKLFFEMMSDPGLGEWYCIIDALDDCEDQETKTLLEGIVAESQGTDGEYPRFLRLLITSRPCGAVRSAILNRKNVRVVHFTDPTGKQLNEADIADYISDHVRQFEHYPEEKKPGVEKQLIEKAGGNFTWTISMIHQLGNKSPDWYNKLLAEIPSGMETMVERIVHRAKPESLLLIQLLAVVQRPLSVTELATLITMKGSPFDDLFALVRTTSAMSIRDKIRFGEESLKICDDEILFFHPSMPKQLHKTWTEDVFREMHLKVAEACLIYLISIDDSHKPLQGRRKADCGAEYQTVLGALPLLEYAAAHWPTHLHCAGPDSADRLWPLLEQSLSCETKRELSFQVYRFWHHDDYVEGQSPLHILVLHNLRSIVRRLFAGDLQPLPLWDVNARDSTGRPPLWWAVTKRHKDMVSLLLNNKSVDCNIRDHDAKISPPVLAIKRGFTDIVRLFLETDSNRISWSRLKSNGRTFTALYWAAISKFEDLVLLLLTRKEFSQDLEERCASQTPLVAAARNGYSEIVMALLRAGARRNSTDDDERLSALSWAARNGQKEVVDCLLRYQDVDIYLRDPRLDRNAFQWAAAHRHEEIASRILAEMYTRWGNQAQPRCISLLLEAAERSQLGALNILLRRDGLMPDSTHRPDGRTALSLAAENGQTTVVQRLMGKDTEVNSVDRDGKTPLMWAADKGHVEVVEVLLESERVYVDAVDSSRRTAYDWALKQGRFEVCKLLTSVQRPLEHRRGASPGKRPLPTTSGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG69</accession>
    <name>A0A1C1CG69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG69"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03638"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01895"/>
    <dbReference type="OrthoDB" id="4160558at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="295" mass="33011" checksum="0BA3A7C0831B10D4" modified="2016-11-02" version="1">MASTARHERGSAFLRIPAEIRLHIYSFLLPKHRLDINLCDPDDIHPPRDILAGKNKKPSPISAMVSLNLAIEAITRSNGLHLLLVSSRTAAEYAGLLAKMAVRFHCPKCFDEWLRNVSYGLGVGIKWLKRVEILFDSEMGARHVGPDLQGMTPALSKFMANEMMKQCQHTVYAYYGRLDLMDPPREVWKYEPYRGDSPPLSRGQPDSRGGGTTLNDSAQAMSQAQINGGLQTHPWVINGGFPPPETRTLLHGALTSWWVVRRGFQISNPRLQSGEGRDESADTTTKWVIKAWLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGR9</accession>
    <name>A0A1C1CGR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGR9"/>
    <dbReference type="STRING" id="86049.A0A1C1CGR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03694"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04628"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="191" mass="20667" checksum="3263FED812FABDAC" modified="2016-11-02" version="1">MAQIAVTSEASSVMPAPVMSSPQGDRSAPRSSSGGLSIGSLVHPQQDYRYGLGTPAFNGFTRQPMHFVPGFTSSDDSMFYTPESSQSPVSEYYGRYPHRQSISSSSSVAAFDPNGASPLISGNMPNPWAPSSGPPSNFPSTMLDDGSYLPTLPYQYPSPTWMESNGLSYDENYQLQLDYSQEIPQPVFPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGW9</accession>
    <name>A0A1C1CGW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cnd1</name>
        <name evidence="14" type="ORF">CLCR_03266</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGW9"/>
    <dbReference type="STRING" id="86049.A0A1C1CGW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03266"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04626"/>
    <dbReference type="eggNOG" id="KOG0414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="87"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="1036"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="822"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="902"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="822"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="928"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT47716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1179" mass="131635" checksum="4D5FA574E73DBF81" modified="2016-11-02" version="1">MDDQVDFDINESLKLYLSDATTIPTPEAASDLLDCENDPESLTPALVDSVLEPVIDVITENPEGLSRSSAFDTLQYLLKQSPVLSPQSLGKILHLIVSGLSTAADVANHDIENDEQETLHQHKRLLEMYGFLLQWSISAVEAKALEKSTTAAARRGGKGAKSKSTSKDEKWDSSNQIQSAMDVMCRVMKLKLNRVFQTTSDRDTFINLFTRSVYLIMESEARVKITAVRMFCFKVLCVAVKHHGHALGAQTSIVQNLTYFEHLSEPMAEFLHILSEQYDYPHLSAEILRELAAKEFSQNDTKGPKSVSAFIVKLSELEPRLVIKEMGLLAKFLDSESHVLRCAVIEVCGNLLADLSKQEEKSETTKIQINAFFDTLEQRFLDTAPFCRVRTMQVLTKICDLEQKFPKRRQNAAELAMQSLQDKSSNVRRNAIKLLKKLVSSHPFSLMHGGQLSHNDWTERLEVVERELDALKPPPDSPGLARTAAGEEPVDQELLDDATQAEVEPKEMSEEEQIAALKKAQEDAVTSEAIGKLQLTRKYYLEALRFIDIIHEASEIAVQLLSSPNKTEVIDVMDFFVTIDAFKVETARNGIRRMLRLIWTKGNSDEGKGVQTHLIDNYKNLFFDAPETFTANDAANFIARNMISLTFGATPAELTSLEQLLSTMFKAGHISDMVVAKLWQVYGVNKEISKAHRRGAIIVLGMIALASPEVVVKEIDTMLRVGLGLLGRTDLVLAKFTCVALRRMIPTAKKAQEKTTGGLAKMSNNHEVLRMLASILLTTSPSKDWYGMAEQAISAIYVLSDHPDVLCSEVLRQKTRLVFQQTKDLKSMSRTPSPEPDAMDIDGEEDVANPENEAQEPEPAHAKQEKPSLALSQLLFAVGHIAVKQIVHLELCELDFKRRKQQQEKDKPLSNPSPEKSAGPTPARRKKTAAEEVLAEKQNEDEKDELDLIGGTTEDDFTEAIAHIRERELLYGPSSLLANFGPLVTEICANNTAYKDRNLQAQATLCLAKLMCVSGEYCEKNLPLLITILERSTDPIVRSNAVIALGDMAVCFNHLIDENTDFLYRRLNDADESVKRTCLMTLTFLILAGQVKVKGQLGEMAKCLEDGDKKIADLARMFFSELATKDNAVYNQFVDMFSVLTQEGPLEGGVMEEEAVKRILKFLCGFIEKATWEDHYGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH10</accession>
    <name>A0A1C1CH10_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trihydroxytoluene oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_03498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH10"/>
    <dbReference type="STRING" id="86049.A0A1C1CH10"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03498"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04543"/>
    <dbReference type="eggNOG" id="ENOG502RMEJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3360610at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000034">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="86"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="237"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="407" mass="45913" checksum="91514BD2CE5AAD9E" modified="2016-11-02" version="1">MNQPDQLKHNITEDALKKGDKVGLFFLPHTHALVLTNANGTVSRGPSPNRGASVRDVDAVGPDSESKREWQKRRGIDTSKQVRIVKLNHMRYQHPDLNKATTFLRDFGMHVVKKGDNERWFRGYGPDQYVYYARQGPKKFLGGSFEVESKEELEKVLKIEGATVLTDGIEEMKDAPGGGYIVTIADPEGFPVNFVYGQAEVKEERAKPGKLLVNDETDKPRVKAFQRYEPGPAAVHKLGHFGINVDDFPAQMDWYTRNFNIYPSDILYVSEEKVDPATGKAARKEVALFGSIDRGQTPVDHHTFFMTTTVPGKDKHVHHSSYEVHDFDTQLLGHQWLAEKKYESVWGVGRHILGSQIFDYWWDVSGFMVEHYADGDLVNEDTPVGYGPAEHEGLAVWGPEVPSSFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH18</accession>
    <name>A0A1C1CH18_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH18"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03716"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="177" mass="18373" checksum="D7EDE5C80835FB22" modified="2016-11-02" version="1">MGMGDLPVLHGNPRPRSETRRPVRIAPRGYRTSGTEKRRSLSSFTQTDIASLDACVASAVDILLSSLDASPTSSFDYTSTASELNSAASGLTSLGITVSSLLSDPASFTGAEPHSGPYVSDIVASYSAYTATHTGSGGSSFSFDTSAFLATATTSQGLQLFTGTTLERYVDNVSQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH98</accession>
    <name>A0A1C1CH98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chlorohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_03424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH98"/>
    <dbReference type="STRING" id="86049.A0A1C1CH98"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03424"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04460"/>
    <dbReference type="eggNOG" id="KOG3968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF37">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650820" evidence="5">
        <location>
            <begin position="22"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="6">
        <location>
            <begin position="229"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT47893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="476" mass="52193" checksum="38CFD9AADEDBBC07" modified="2016-11-02" version="1">MFVQSTFLALLVACFASSTIAQNSSFLFHGATIIAFNESSSKISVLRNSSLLVRNDRVAGLFENSVPSDLPKSTEYVDITGKMISPGFINTHHHLWQTAFKTLASNTTLAEYVQRYGEFSPAVNAFEPNDIYLGQLAGSLELLHAGTTTVLDHAHGDFSNEALDAALNATLDSGIRTFFAPAIHDLSLINGYSIEDQKAKLLSLVNDTRLQNNDVVSLGLAYDRFAQASEEELLERYGALNTSTPVVLSHASFISAIDMQLLRETKQYISTTPESEFHYGHLHSQVRHIQDQASLGVDTHFTFSSDMVGQARLWLQALRADSFRLTLEEDLEIPYTNPMSVEQAFLLITRNGALALRRPDIGIIAVGAKADLVVFDGSSPNLLGWDDPIAAVILHSNVGDISDVVVNGKFVKRDGKLAYSDYAAVRQDFLRSAKKIQNAWKEMEFGPLESNPLGFGITPYAQPRQIDVQAGPGTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHU4</accession>
    <name>A0A1C1CHU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NmrA-like family domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NMRAL1</name>
        <name evidence="9" type="ORF">CLCR_04172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHU4"/>
    <dbReference type="STRING" id="86049.A0A1C1CHU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04172"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08245"/>
    <dbReference type="eggNOG" id="ENOG502R80G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000181">
        <property type="entry name" value="NmrA-like family domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="8">
        <location>
            <begin position="17"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT48093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="329" mass="35779" checksum="4E435E6177C65C3D" modified="2016-11-02" version="1">MGIIDNIKSKMNGGHSKKVVVVFGATGKQGGSVVRSILGDPKTASQFSIRAITRDPSKPAAQELTKLGCECVPADADDKDSLRRALEGAYAVFAVTNFWEKKSAAAEIQQGKNMADVAKEVGVQHYICSSLMNVTKLSGGKLSKVAHFDSKAEVEDYVRAIGLPATFFMPGFYMSNIPGQSLNNMQGPYSFALPIPTDSPIPLFDTEHDTGKFVKAILLNRERVLGQRIYGATDYYTPEQIIADFQAVKTKDGQGGAAKQVPEPAFKKILAGKGLPEPIQEEMLENMLLMPQFGYYGGADLKASHSILDEPLTTWKEYVAKTPVWADVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI25</accession>
    <name>A0A1C1CI25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein TOXD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TOXD</name>
        <name evidence="4" type="ORF">CLCR_04164</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI25"/>
    <dbReference type="STRING" id="86049.A0A1C1CI25"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04164"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08325"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="11"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="347" mass="37294" checksum="0C1DA83C6537A3C8" modified="2016-11-02" version="1">MKAVVIKGKEATVDRDRPTPKLRDDYILVKTAAVALNPTDWKHVAFGLGAQGGLVGCDFSGTVEEVGSAVTKSWSKGDRVAGVAHGGNFVQPDDGAFAEYVLAKGDIQIKIPDSLSFEAAATLPLGTTTVMQGLFQKALKLNWPTDPIKEKTYVLIYGGSTATGALGIQFANLAGYTVLTTCSPRNFDYVKSLGAAEVFDYNDKEAAAKIRQLTDDKLNLAWDTISEKDSARFCADALSTGSGGRYGSILPVSCPRDDVESVSTLMYTIFGEPFKFGPQEFPAVDEDFEYAKKFLAMTEGLLKEGKIKAHKQTVGKDGLEGVLKGMEDMTNGKVSGEKLVYRVAETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIG8</accession>
    <name>A0A1C1CIG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF907 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_03913</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIG8"/>
    <dbReference type="STRING" id="86049.A0A1C1CIG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03913"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08468"/>
    <dbReference type="eggNOG" id="ENOG502QTQ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2115177at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF5">
        <property type="entry name" value="DUF907 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G06100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650880" evidence="9">
        <location>
            <begin position="21"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="567"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="11">
        <location>
            <begin position="22"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="10">
        <location>
            <begin position="29"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="652"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT48324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="712" mass="77790" checksum="47983D79C9B7AB17" modified="2016-11-02" version="1">MWRTSVVALASLALLPSVLATDILKTNGFSNCNNGSSTVKVNNVDISFDKSTDTIDFDVSGTSTKEQFVTAELIVTAYGVNVYNNSFDPCANDTKVDQLCPVPAGTFAANGSQVIPSSYTDLIPSIAYSLPDLDGNAQLVLKNKDGSEVACVQSGVSNGKTTDVPAVSYVAAAIAAGALAVSLVGAAASGAHPGSTSSSPGFFEVMWWFQGMAMNGMHSVNYPGVYRSFAKNFAFSTGLVSWGGLQASIDSFRSHTGGNLTINSYNNLKNATLVYPDGSTVATTSGIAKRALLLVARQVTTSINGTSDESSSSDSQESHLVQGIQGYVEQLTIPETNTFLTVLLIFAIVLAAIVVGILLFKVILEAWALFGKFPKSLTTFRKEYWRIMFQTITNLVFLLYGVWTLYCIFQFTHGDSWAAKLLAGVTLGAFTALLAFYTWKIFTVVRKLKKIEGSADALFENKETWKKYKLFYENYKKGYWWLFIPAIIYMFAKGCVLAAGDGHGLVQTIGQLVIEALMLILLLWSRPYQRKSGNWINIIIQIVRVLSVICILVFVEELGIAQTTKTITGVVLIAVQSGLTAILALLIVINSIITCFRENPHRKRRKAAEKNLSRDLEGDAFLMQPTPFSSPPRHDRKMGELGGYEQVRAQAFSRFGPRRDESQETLVTRGADMGKTGYRSLSQGRSDHSGSPPPFSREPRLPDLAFEQYRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIH7</accession>
    <name>A0A1C1CIH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">CTP synthase</fullName>
            <ecNumber evidence="3 12">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ura7</name>
        <name evidence="16" type="ORF">CLCR_03954</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="3 12"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIH7"/>
    <dbReference type="STRING" id="86049.A0A1C1CIH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03954"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08414"/>
    <dbReference type="eggNOG" id="KOG2387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="15">
        <location>
            <begin position="2"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="14">
        <location>
            <begin position="311"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="573"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT48267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="597" mass="65941" checksum="105AB39A44412253" modified="2016-11-02" version="1">MKYVLVSGGVISGIGKGIIASSTGLLLKTVGLKVTAIKIDPYLNVDAGTMAPTEHGECFVLDDGGEVDLDLGNYERYLNVTLTLENSITTGKMYQHVIERERRGDYLGKTVQVVPHITNAIQDWIERVARIPVDDTKEEPDVCIIELGGTVGDIESAPFIEAMRQLRRRAGRDNFVHIHVSLVPVISGEQKTKPTQQAIRDARAAGLAPDLQPLEDATINKIAMFCQVEPMQVLAVHDVESTYHVPLLLEQQKLPDQLRDLFRLDAYPIAPTLVTRGQQLWSDWKKLTTSQERFLETEKVTIALVGKYTNLHDSYLSVIKALEHSAMACQRKLNLIWVDAGNLEKATLESNPETYHKAWHELCTADGVLVPGGFGHRGTEGMVAAANWARTKPKPYLGICLGMQVAVIEYARNVCGLKSAHSVELDARTTDPVVVFMPEIDKATMGGNMRLGLRPTLFQEKTSWSRLRKLYSNAPAVNERHRHRYEVNPEYITRLSDAGLTFIGKDDKGERMEVIELEDHPWFVGVQFHPEYLSRVLRPSPPYLGFVAASAGVLEKVTTQSAAMQEKVNGDAAGEVHGGVNGVNGLTNGVKPGSHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIM0</accession>
    <name>A0A1C1CIM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">bbp</name>
        <name evidence="20" type="ORF">CLCR_03919</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the BBP/SF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIM0"/>
    <dbReference type="STRING" id="86049.A0A1C1CIM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03919"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08498"/>
    <dbReference type="eggNOG" id="KOG0119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000030">
        <property type="entry name" value="Branchpoint-bridging protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000024">
        <property type="entry name" value="Branchpoint-bridging protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="19">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="19">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="343"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="386"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="253"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="546"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCT48360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="581" mass="62933" checksum="DDA1CB66A738C45E" modified="2016-11-02" version="1">MSWRNQGITGSNNIPLGNRRRFGGDGNSDSQYESSKNSPFDGDSGSKRGRSPPRAEPSADGEKRRRKRNRWGDAAENKAAGLMGLPTMIQANMTAEQLEAYTLHLRIEEISQKLRINDVVPAEADRSPSPPPQYDNFGRRVNTREFRYRKRLEDERHKLIEKAMKTIPNYHPPSDYRRPTKTQEKVYVPVNDYPEINFIGLLIGPRGNTLKKMETESGAKIAIRGKGSVKEGKGRSDAAHTSNQEEDLHCLIMADTEEKVNKAKALIHNVIETAASIPEGQNELKRNQLRELAALNGTLRDDENQACQNCGQIGHRKYDCPEQRNFTANIICRVCGNAGHMARDCPDRQRGSDTRNNIPGGFGGPQRRIGGGDAVDREMESLMQELSGNASGNGPAGHIEAAPAGYDRGDSYGGGGGGDSRPWARQQPGAGTGGPAPWQRDRQERDYGNRERNYGHRERDYGDRDGGSSLPPWQQSRGGDSHGGYGAAPGQPAAAPWQQQPPPGQNYGAYGGYAGYDAQAAYGAPPAGAPPGLSSFLQQYGMAAGAPPPPPDAGAPPPPPDDQPPPPPGMGDYVPPPLPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIN0</accession>
    <name>A0A1C1CIN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_04392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIN0"/>
    <dbReference type="STRING" id="86049.A0A1C1CIN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04392"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08436"/>
    <dbReference type="eggNOG" id="ENOG502S0YM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2131401at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF6">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19018" checksum="7FD31FCC0B3296CB" modified="2016-11-02" version="1">MTTYGAGVPLSYETPEFPALYWPVRATPGEARYLYFLGDIYRYTLYWTLITFVAAHACVATWAVLMQFASATQRRKYLNSPQGRKLRAKNRRLLGENPIGETLSWVWIVPVVYIVIGASEALLAGSLVGLVLGAVYNAGYFRMSTWTPLLWGVINMLVLVVSSFRIQGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIV4</accession>
    <name>A0A1C1CIV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Translin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tsn1</name>
        <name evidence="8" type="ORF">CLCR_04313</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIV4"/>
    <dbReference type="STRING" id="86049.A0A1C1CIV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04313"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08566"/>
    <dbReference type="eggNOG" id="KOG3067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990605">
        <property type="term" value="F:GU repeat RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035939">
        <property type="term" value="F:microsatellite binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="240" mass="26729" checksum="1F1C9C3C052DC80F" modified="2016-11-02" version="1">MAGDTAMTNEAAGPSPNVDPAIFSSLQAKIDQETGIKDELRAIVDTLSKQGRVTQSILSRVHNTPTAELETAVLVPCADSLAAQAATVKTLADAASKYPFYKWNNIWQRDMQNVVSSLQLHDWLKGGNLITLEEVGQRLNVPVNVKDEDTFHITIEDYLLALTYTIEELSRLAPNAVTLGDYARPLQISRFIKDVHAGFQLLNLKNDILRRRNDALKYNVKKVEDVVYDLSLRGLIPKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIX0</accession>
    <name>A0A1C1CIX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04186"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08598"/>
    <dbReference type="OrthoDB" id="4148932at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="364" mass="42889" checksum="A65F6A10B29AF930" modified="2016-11-02" version="1">METSATYLQNALAEESATFLSLPKEARRMIFQLIFPKIQIYCHYEGPYSQFDEQSRRRIEHAERRWYSRGWHFEGALLLVCKQIHLEVKSVIFSAPVTVGGHWKGVFCPSDFPTGWDVSSRVVKVHPGRTFALSRTQSIYGYRFLDPVNCPNLRTVSTNIGRYICKDYNHQIHYPFRLLPTIYQCLRRQFETREHVSTVHLTDLEAICDANALQHARETDRFIKKRNLAFKCITLFEVVCWEDTACEGEPYREWDPRYDQGPDFQHAFSVLVLWDKDGLRVENMPRLDGFFAEHGRRMYSSSNIWKADEWFAKGRTIWWHDRSDGRLSRWFKSQELEGREHLNRKSLALEGMDDSSNTNVLNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIX2</accession>
    <name>A0A1C1CIX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIX2"/>
    <dbReference type="STRING" id="86049.A0A1C1CIX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04272"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08584"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000171">
        <property type="entry name" value="Glycosyl transferase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="303" mass="34616" checksum="4726DEA5B23CBCBD" modified="2016-11-02" version="1">MEGPKVWTTLITNTKYLSGLLTLDYSLKKHGSKYPLVALYTDTFPPEGLEALQSRNIPAKHIPYLLPSIPKEYTNDPRFYDCWSKLTPFSLTEYDRVVQLDSDMLVLKNMDELMELELDPPEMNGEGNRVYAASHACACNPLNKPHYPKHWIPENCGFTTQHNTPDDAQIHGPPPTAGIGCPNGGLVVCNPSKGIYDKILEAMQNGDITSNYDFADQSLLGDQFYGRWVGLPYIYNALKTLRWKGVHDAIWRDDQVKNVHYILSPKPWDEKYEEIQDEAHRWWHPVNNERLAHEKAIGIDDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ14</accession>
    <name>A0A1C1CJ14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ14"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ14"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03946"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08645"/>
    <dbReference type="eggNOG" id="ENOG502RZ8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5242705at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="668" mass="71538" checksum="A0E716CF57B375FB" modified="2016-11-02" version="1">MPGQVANEDAAAAGVCLMESMCVIQEGARRLGTSTGYVFWLLLCILARTVSLLLQMPRSSERPLSEPMLSSSPSSHSPSIPLRQPGKTAESTVYFPLGNVEGSPTHAHPRPHAQRRCGPIEWAVEIIAWITSLAGMAAVILVLHVYDDRPLSEWPHRVSLNAVISTLALVSKACLLAVTASCISQLKWTRLTNHRRPLIELEQFDAASRGVRGSLRMIVTPASWHIALVGAVVTVAAIAIGPFTQQAITYPLRTVAVSTAIVPRTQTYQNAAPGGLLGIRDVPLTMKAAAYSGLFDPGAAATRASTTAQCSTGNCTFSEYTSLAVCSRCVNVTRLVARNGCSGSGSSTQCRSYTLPNQLLLDGDGGLINTTANAIPNQVEVENLGASLINLSIVLSQANFSTTPDDIRAYDCSIYFCLQKYQTSFQNGVFEENVSDEYISDVPRENSTVDYNIAAPPAFVAPNEQTNFSVSDFSYQAVGSYLRKLLVGEAFAILAEASYSSDAMDALYNSLSSNGSGTSIIDALATSMTAEIRSSPGANIAWALGASTQDSTYIHVRWAWLALPLALQALALLLLGMTMISSFRSRTPIWKSSLLAALFLAPSGGFSERPEHPHGVSAINSNGNISPNVCTLKEMEAKAKEMRMRLLRDEGGRLRLQYPLHPASVSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ90</accession>
    <name>A0A1C1CJ90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ90"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04273"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10269"/>
    <dbReference type="eggNOG" id="ENOG502RW6U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4157036at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="303" mass="33569" checksum="1A2FFD80348FB1CF" modified="2016-11-02" version="1">MSIHDPKTSRRLSRSLNDLDLIIKKNPIPGVDTHYHIYSESSFDSNWIPARPLEPAHPPPVRKPTPPGLPPFGSWEATLLRLERRLLSRTSLTLRQWLHSHDESCEQDVTSVNAQSTAPDRVSPVYSTQSLPQRPHEVQPEHRDLLRRTLAAIGMSRVLDPDAVERASLTIPHTSALEQAPSSAIKMVLPPWVYMANVPGPLARADDGTYVRGAFGPRFSGHGIGERDIEDLPLARMEKMEHEPAELPATLAALRRTDATSGHRSASAIGPAMEEEEDDESKCDGCCAKLCMWIWGIPAAMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJB7</accession>
    <name>A0A1C1CJB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04457"/>
    <dbReference type="OrthoDB" id="4146637at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="78" mass="8891" checksum="B208495A19330E73" modified="2016-11-02" version="1">MSCECSICEVFERTSDDLAKAAHRAELQRGRQKLHNLYQGKESMSDDAEEETYRTLMRLAGEDGLKDLKQMLQHLGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJP4</accession>
    <name>A0A1C1CJP4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative camk family protein kinase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJP4"/>
    <dbReference type="STRING" id="86049.A0A1C1CJP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04777"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03160"/>
    <dbReference type="eggNOG" id="KOG0615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="254"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="546" mass="61229" checksum="379645BF2B916655" modified="2016-11-02" version="1">MANADEDGTETIPNSPDTLLLEDSFFSPRTNAKLRGDFARLVPVNHNAILAFHSIAERTRLEPDWNPHIRRFLFIEDTPRAISPEWDGTSDTNSDATGPLQQGQVLAGYYRLSLDLITNHPRLGWVLGSGRKDLPNGGVDFLLTLQKNRHHVHGRHARLVHAQNGALMLVVGKGKAVVVNGIERMEGSQRVMGSVRTALAFGNLSYNLEFTGLNESSYRDKLGELFTKLHPDGDVPPMSLELTPLEHHHELHGFLIHSPFASGASGVVSAGFEKSTGRAVAIKRVKRTPATVARIQLEIQIYRKIGDHPNLCHLMADFYSGGDEYSTGKSKINDVYLVHSPLARQTFLDLTLSKRPAEVRLSAFHQVMKGLAHLHQHGIMHRDLKPTNMMLVSYQPVHAIIIDYGSATFDTTSTDHYCGTIAYLAPEVLRLKYERNRNLRHDAYDCRVDVWSMGLSAYQLFFQEPCRWEKGVSNTAHKEIIRKLRFRPGSVADTLEKMLSWQSVHRPTADEVLRFKGIWSKLGDAAERPEDDRAAHPPHVAKKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJU2</accession>
    <name>A0A1C1CJU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJU2"/>
    <dbReference type="STRING" id="86049.A0A1C1CJU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04881"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03119"/>
    <dbReference type="eggNOG" id="ENOG502S1KY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04370">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46364">
        <property type="entry name" value="OS08G0421900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="2">
        <location>
            <begin position="131"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="438" mass="50111" checksum="D44DFBBF86D416A7" modified="2016-11-02" version="1">MAGRKRKASEIDDGTSERRCSIKSSPSNKALMNHHSPQPSKKEDASEADELQETIETEASADTSIAVDCPVWPKSKRYLARLKREDLYTGHDAPSLPGTRRLEIDYAVKPGSFWLKLRQYKNARFKDPVDVTYSAGDIVYVNRRLPVPAPLSTDASTDERLAYDKENLWVGQIAEFRAASTNKVFVRVFWLYWPDELPMHRQPYHGNRELVMSNHVDIIEAQTIACHADISYWDEYDDSNKTVLDERYWRQTYDVTKMLTAPHLALSKLRKFCICGGYDNPGIDMFQCHMTGCGMWNHEQCLIADIEERAWEKFKAGLLGHETQETEEHKTFSQKVVEKVGHLVGKGIGVSEVQDEAHLDRIPSSSSKHAKLVAGHKKPWARKLEARITKVRKAEDETTHHAIVRQLVPTANTKAKPSFEPKIWNMEMKCLRCHHSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKB6</accession>
    <name>A0A1C1CKB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11329"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02965"/>
    <dbReference type="OrthoDB" id="4139598at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="entry name" value="YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="98" mass="10805" checksum="0E8E6BD52E07CFBB" modified="2016-11-02" version="1">MLQTITPLFPFLPNPHSYLQSLSLSLHRLFKVSHLQTTDPVTMADDATKAKLRATFDKLTPQDFAAVAGNREALTKKVAEVYGISEAEAKTKVDEAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLQ7</accession>
    <name>A0A1C1CLQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="16">LTA-4 hydrolase</shortName>
            <ecNumber evidence="16">3.3.2.10</ecNumber>
            <ecNumber evidence="16">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CLCR_04711</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="16"/>
    <dbReference type="EC" id="3.4.11.-" evidence="16"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLQ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CLQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04711"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03332"/>
    <dbReference type="eggNOG" id="KOG1047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061957">
        <property type="term" value="C:NVT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120113">
        <property type="term" value="P:cytoplasm to vacuole targeting by the NVT pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000009">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 16" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="17">
        <location>
            <begin position="463"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="264"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="566"/>
            <end position="568"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT49419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="612" mass="70052" checksum="3C6AB1B8D2438769" modified="2016-11-02" version="1">MATINRPRDPNTLSNYNNWRTVHTSTDFDILFDEQKLKGSVTHSFEAITDGESDAILLDSNHVQIHSIKADGKAAEWELLSRLEPYGNPLKIKLDRKLKLKEKIDIRIDVETTAACTALQWLTPAQTSNKKHPYMFSQCQAIHARSIFPCQDTPDVKAPFDFTIKSPLPVIASGIGAKDNGSSQVYKFHQKVPIPAYLFAIASGDIATAQVGPRSIVATGPDELKECKWELEEDTEKFLKAGESLVYPYAWGEYNVLVLPPSFPYGGMENPIYTFATPTIISGDRQNVDVIAHELSHSWSGNLVSNASWEHFWLNEGWTTYLERRIQAIVHGGDQWRDFSAIVGWRALADSIEQFGEQHEFTKLVIDLKGKDPDDAFSSIPYEKGFNFLYYIEKLISKEEFDKFIPHYFETWRGKSLDSYDFKATLLDFFKPNDGVSEKLARIDWDTWFYAPGFPPKPDFDTSLVDQCYDLAAQWEKFTHNPNPDFGPSKFDIDGWSANQIVVFLEKLLSFADKLPQPHVNYMGFIYSLKETRNVEISARYYQIAMKANDWTIKNFVVKLLGEVGRMKFVRPLYRGLMKMDYQLAVETFEKNKDFYHPICRGLVAKDLFGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLW1</accession>
    <name>A0A1C1CLW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_06898</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06898"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09759"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="25"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT49496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="528" mass="59052" checksum="C3E8D26643AB902B" modified="2016-11-02" version="1">MVGGAPISANPLKLDVRSHSKCLVICVIATLSTFQYGLDYALVGGFLSMPGFLEVFGYYSEDLGRWNIDPTVQQLISSLMTIGTFLSSLMVGPFSMKFGRRQGLWAAALLNYIATAIQLGTTSKGALYFSRLLLGISVGWFLTFAQLYVHEAAPAHLRGIAFAVYQVMLSIGSIVGASVDFGTHDMPGRDAYQIPLAIFFVAPTLQSVLMYFFAPESPRWLMTQRKEEAAEASLRKLRNPNIDELEFQAELNEIRQSTREQLEQNKKALFLEMWRGTNLRRTLLSIAVVCFHSANGSSWVNIYTTYFLQIAGVENAFAYSVMVTCIGLIGVLFSFSFVRLVDRRTVMLVGIFACGICQLIPAIVWTKSPGTESSGKIVVAFISLFTFFYVAYAPYAWLLGGEYVNNHLRAFTFGLATAMNFLGNWAGTFSAPYFINPAKFNWGPKYGYIWFASNMVCVVFTWFFLPETRDRTLEEIHEMFEARVPARKFKHYVCSNVESYAAEAMGKELGERKTSEAAHVEEMPDSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM13</accession>
    <name>A0A1C1CM13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM13"/>
    <dbReference type="STRING" id="86049.A0A1C1CM13"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07260"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09843"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="98"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="331" mass="37342" checksum="774A1365C864CA60" modified="2016-11-02" version="1">MTDNHKAIPPETDSELAAIWKKHGMPKFFVPRPEQIAETRRLHARGNVRFMQSAFVKETLGEQRLWTEEDRPVTVRDGNSITVRTYRPTTIPGTRPVMVFAHSGGWCMGGLDTEEFICQLLCIKLGIIVVNVGYRLAPEWRFPTPILDFYDVLKWVSVNAEALGGDLSKGFLTGGASAGGNVTSMAAAQARDEHLQPRLTGHLFLCTGMPHSYIDSTGDILNLFPEQLAHGSWEKYKSGPVATREMNVLYACPVYYQAAEMDIWRDSAVFYCDKIRQAGDQAKIDIYPGVPHLWWAMYPQLSINKKWVKDLVDGVEWLLKQNRDPAKSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM78</accession>
    <name>A0A1C1CM78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM78"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07590"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09837"/>
    <dbReference type="eggNOG" id="ENOG502T4YX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF7">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT49579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="225" mass="24929" checksum="21B671F4118666DC" modified="2016-11-02" version="1">MAPTFFDLPLEIRLDIYSLVFGSGMALLEAKVEDDSCCMVPRRGTILNPSPRSSQLLRVSRTILLEARPIFYANTVFHIRSLVFAGALPTRLTDGHPCAPHIKHLVWQLDCDMLKHFYVQELQIGVPEISGWSSFEIRCCADTWRDSFLGEWCDREAFLRGRAQVVGDARMFHDAMSGGGGGSLTLVEDRSQLGSGRIILRIDSARSSVKQQRSSRAGAVVVGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMA3</accession>
    <name>A0A1C1CMA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alpha-L-rhamnosidase rgxB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rgxB</name>
        <name evidence="12" type="ORF">CLCR_06846</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMA3"/>
    <dbReference type="STRING" id="86049.A0A1C1CMA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06846"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09858"/>
    <dbReference type="eggNOG" id="ENOG502QRJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650956" evidence="11">
        <location>
            <begin position="18"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="470"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT49609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="517" mass="56515" checksum="B121915F8DF15C9C" modified="2016-11-02" version="1">MFSTLVLLAGVASSAIAYVVNNGTACYVYPESLTHFGQPVDDTPSILHAFELCGTNGSVIFQNYTYNINQVMNTTGLVNCDVELHGEMRWSDNIPYWLGHSYSVTYANLSTAWFFGGENVTFKGFGKGQFYGNGQAWYNENRNNSNQPGRPIGFTILNAKNLWMDGVSWRQAQFWHSFVSHSQNVTMSNIYMNSTSNNTWFTVNTDGTDTWNSRDIFFYNWTVEGGDDCIAIKGNSTNIVSRNITCYRTHGMPIGSVGQDPTHPDFVRDIVYEDVHLIDSTNGAWIKAWQGKATDITNNGQAGGGGGGSITNVTYRNFRFENVGQPISITQCVYGHDSSVCDTSQLQISNVTWENITGTSHFDVASVIHCSPLVPCPGLKFIDVNITTVNASLGRPSLPQVNLCANMVDQNATGEDATGIPCHGFAPNDMPNVLYRNWPELLSEVILSVTVPEAQRDNCLHPGPDAAAAGSVGCAEAGSGQGELKHHDDDDEEEEEEGKVVVVVVVAAYQQKLNSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMT0</accession>
    <name>A0A1C1CMT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Noorani M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMT0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06845"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08751"/>
    <dbReference type="OrthoDB" id="5384871at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="9"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="606" mass="68842" checksum="D3C3FB07B566DD15" modified="2016-11-02" version="1">MEASLFPQPCRLLSLPAEVKLHIVEFLDSRRDLYNLSQTCRILEDMVMARLYHTVDFELSQTRKPTFREPVTQSVRELTIRNGRTQRRDSMDRRRRISDAGSISAGVNGLLEKIPRNRLTRFELFHQTPMTLQVLDVLARRHGSTLQHLSFYDLEAGQEGLVPKTLSSLDARTVNDGEGVEKIISANKKTLQSLCLGQEKQLIERYQQSRLSLYNRIPQPSETFFASAYALDSFPQLRELSLSGLDVSLLQPASIPQALFFCRLERLALESCPGSIELLESIASAFHWATTAPEAPHTPQATPSLKHFLFRHENPTTALKDATVRFLTSFTGLRTLSLLFENAAVLERPSTFIAEHGPTLETLVFESRIQPREHLSLDTSRPFGVGGYSHELWEESINDIARLCPNLVELGMGFPWTDEMVRLRKTALPTLQHLKTIHIRNFPENEAFSQLGDYSIKEYATKFIEWVFPARVGGARPALTHLAIGPTIYESRWKITPPLEPQSQTPATTSTNTSSTHPTTTTTTTTAAMRAFNMSTYRPTPPRPQARAAMRSQPPEFLRTHHFCLDWATTRFNRWSALITPVSEKFMEEITGQKPLRGVFEQVWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMY8</accession>
    <name>A0A1C1CMY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07052"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08790"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="475" mass="53274" checksum="AF7B814BD6613481" modified="2016-11-02" version="1">MDKKNPNWGSVRSKLTQEGYMYRMKLGNPPTGSDKHSSQQRPPSSISSSKVQLGLPAGDHAFRPVPSSALDPDRAAVELRTISGLLVQLNLGRAFRSDHHLDPNAAIEFLYRCFAPFVIHRRNESIGFEPGDFLDPVMLEDNMLAQALVVWTSEMRDRFSPEPESAGELLLAHRSTVLHELRERISSSGRCTSDPVMWTILMLAATELVQDNMQAMGTHLGALRHIIYLRGGVNSTSSSEWVKLILLQFEGFLNYRQFDRVRSAGFGDASSVAQHTHCPFPPEFKDRMAKLPPGFTEIFGVCPMNLHVLSLIERIHQWTQQLADLAQVGQEGEAVESIADAMSLDSFRAFDLLQQDRLRATERLLVLGLCAFCIYMNGRIVYSVMEWALRLHCMAQVTKQMNPFEEDVRRSMIWVATVLMATGGNGSPSWQLGGRIIRACRGAHSPLQAIARRNQRSYFWHANLTEKLTAAALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CND9</accession>
    <name>A0A1C1CND9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CND9"/>
    <dbReference type="STRING" id="86049.A0A1C1CND9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07237"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08936"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="353" mass="38592" checksum="DFD68E6C8FF3CEC2" modified="2016-11-02" version="1">MPTTLVTGSTGFVGASVVDELLCQSHTLILAVRSPSSAKALIENNPSWPASALTVFPVPDFTAPGAFDSVFQKHPEIEYIVHVAAPMLDNPAHTDFVEHFEKPSVLGNLELLKSAKEYGKNVKAISVTGSLNAITTGSQEDVKSRVFGNKEWLPLGREDAIQANHNYASPFLVPSISYCVGKKLGEEAIWKFVKEERPSFTVTNFMPPLIWGPMLQPVKDIGRINFSNSLIKAIMDSKSSETGKVPNSAFPGWIDVRDLAQLQILALTTPGASDKRFIVGRAMIFNQVADVLRNDAQLGLADRVGEDNDEASTLTLPRLDISEVEEVFKYNWTPLSETVKDAAASLLEIEKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNM8</accession>
    <name>A0A1C1CNM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07815"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="86" mass="9327" checksum="638BA13889410A0D" modified="2016-11-02" version="1">MAFIPPSNLQLSSIYLMSNLTAVQRSDPAKPTRAQKGAKSDSSAWSFSRETLEVTKPVASPPGATPNTVASPAWRYAHSKMQFPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNM9</accession>
    <name>A0A1C1CNM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07804"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="94" mass="10859" checksum="44FD0CF436A54639" modified="2016-11-02" version="1">MSPIFFDIDPLSLSLTDPILLKWCACAKEDLEFYTQQWMESSGNLPRAAASQRNQVWGRDRLARIRSTFLHRMHPEVMRYITTGQLDPGSKGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP07</accession>
    <name>A0A1C1CP07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Siderophore iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP07"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06773"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00341"/>
    <dbReference type="OrthoDB" id="2587356at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650999" evidence="6">
        <location>
            <begin position="29"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="103"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="628" mass="67151" checksum="7927BC6FBF7983E7" modified="2016-11-02" version="1">MAPLASVCICGLAAAMMLFKLELHLSEADLSLSSLSPSTLTSKFRSTKVKSAAAVMMAVEVEKGYAHANTHDTESANAVEVHNIERIPTEEIENYHGLTVQVLLVYLSLWVLCFGQLMNLVGAGAFARDIAVTVGGSDQTVWLAQVIAILTTCLGPIISQAADYWGRKWFLTISTGLGAVGCLVVSRATSMPMAIAGQVIVGPAYGAQALIYAVGSEILPRRWRPAAQAGLHMALSVGATIGLLAGSAMIRDYATGWRAYWYMTTAMFAFSAVIFGLLYNPPSHQLRQSLSTWEKLARLDWVAYALLTVGIVLFTIGLSWAKNPYEWSDPHVLVPFVVGLVFLLGLAAHQTWLKKDGLVHHDLFRKDRNFAIAMLGLATEDMMFFAANIYYPFQVSVVYGADAFSSGLHFSITFLASMAFSCVVAAYSSYTRRLREPVLAAFILFVLFYALMATSNLSRASATAMWAYPILLGASTAGCLPTLIAAAQLSAPPELIAITSGLLIAVRTLGASVALAVYQAIFASTISVNLPKDIAAAVLPLGLSVDLLPEFIGALSNRNQTALMSIPGVTPTIIGAGAQGLQQAYLSSFKDIWMAAAAFAAVAVIVSAFLINPAKDLNMHVDAPLDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP98</accession>
    <name>A0A1C1CP98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP98"/>
    <dbReference type="STRING" id="86049.A0A1C1CP98"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07097"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05656"/>
    <dbReference type="eggNOG" id="ENOG502T6X5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4144012at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="491" mass="54575" checksum="45F5FD2065F2A5C2" modified="2016-11-02" version="1">MPSVQGFNITVEGVDGTPFTTYGTRSRGNVVYTSMEARDGARFQIRVKPDFPFPEPKDPIVGGEQQPVSRQSLESSGANNAMDCDEPYGEPNRTYEFFASVYIDGNSRSEDNLQIPTEPGEQYYRSEGHVFKGRCCGAVMEDDVVSGSDSESGMLTRYLVLPWVFRQKGIDVLLGHMNISKTDADIPTTDLEQDLADMTEAMARNGLSKPAGSKRGQIDIIITREVPVKVVRPKKYGQQEDTVHRDNDDCNTHEVTVDANNKRHIRTTTVTTRPYRADEQFFCKVCISYYDITKLRKLGLCAQDGTPIDRRLLALSSRPVSPGPLKRHSHYESGRHGLRTDHPMLSDGEESASSDSTSDSDVPRRTKRHRAITSRRRKARLTKPRKNNQMLGWTAREGPESSNRNARAAPPPSTSLVLPEFHFDPNDEVSGWARELHAALGTPRATDSQLQLANASAEPDDVHTATGDMGLITVGTEIVELSDEVDILHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPB1</accession>
    <name>A0A1C1CPB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPB1"/>
    <dbReference type="STRING" id="86049.A0A1C1CPB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07227"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05644"/>
    <dbReference type="eggNOG" id="ENOG502QUVP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2141239at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650945" description="Circumsporozoite protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="39126" checksum="7C73D82609ABC10F" modified="2016-11-02" version="1">MFAKSTAIAALLAVAQARFGQEQIPIPAIAAVQGGAPGAAATIAGAAVSDVLAGSNACNKLKRGDQIIAELGTGADAIAAAIGIVAAEKNFNPFAQSIPTICSDPTLPATDILRGITPLIDPAVVGSDIANALSASTQANPLDATGKSVADLLAENGFTNFTAQAADGTTSAVDAGGAAGGAANEAADGGAVATAVEASATAAVTTAVAAACGVVEATAAAAVADTASSAAPAASTATAVAAAENTAAAAGGAAETSDVAGADFGLCVPTMKFEGGLGGRPATEFTFLPIDPLVAQGQQEALNPSMHSLGPPSLSSNANATLLDIITNRICDQLTNVCEANDAAKTLCKSVQAQILALGTRDKTTADTWNTALGFPGTVTNPDGGPAEPPAKMRMVRSYKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPH2</accession>
    <name>A0A1C1CPH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPH2"/>
    <dbReference type="STRING" id="86049.A0A1C1CPH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07358"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05593"/>
    <dbReference type="eggNOG" id="ENOG502SIIY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="321" mass="36496" checksum="6476E336FA6EF5F7" modified="2016-11-02" version="1">MEPDDNIAVDDEGYDTHSAGTSYVTSIASEIRNGIEEYGRRWASYGKHFYGLPIDDAEQDRNDLQHYKFFLMYEGRLHLAPIDPQPQNILDLGTGSGIWAIEAADLYPSARVIGVDIAAVQPSWVSPNCQFEILDVETSWEFRRNSFDLIHAREFLFAIRDWPALISQAYDHLRPGGYFELSVTVPEVGCDDGTCPPDSQYAELGKIFFQIAEAMGLDGNASRLWKDQLLARGFQDVHETVFKMPTNDWPKDRRMKTIGKLEMQNFFQYAQAGFERGATALLGMDRAQLAVMLAHTRREILDRNIHTYVKFVNVYGRKPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPP0</accession>
    <name>A0A1C1CPP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07525"/>
    <dbReference type="OrthoDB" id="4161272at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="262" mass="28977" checksum="4E5B6F3F0A929033" modified="2016-11-02" version="1">MIAVPTGSIWENEAKDELRISLHEAGIPKTTCIWSDANASAMYDLFETAEKEGTGIVDIANKEEVRIVCDIGGLTVTHDADLSGAIKYGVTGQFRAWRPQFPLVHFLFVTSCPEMGSPDSAGVFEVRIPNLEKGGWVLREEVLTDNDKSPTPYVDIPYRLELLLEELMPKLKLDILTQAGGRLGDDMTWIIPLKTLYKHLTSVGDFKKKAEESLEEDVGLELEPAASGSPIQYTAGIVNPGAWYADENFGRLDDDFVDTRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ04</accession>
    <name>A0A1C1CQ04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative HATPase c domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ04"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ04"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06535"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05450"/>
    <dbReference type="eggNOG" id="ENOG502QPMA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10031156at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="27"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1413"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1494"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1743"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1762" mass="195564" checksum="46D60AA2261C1D0C" modified="2016-11-02" version="1">MDFDALRARTLRSGADEEAVTVNTRALIDKVLARYSGEWTVLRELLQNAADASATKITIKFETIPSATVPLPADSSSSSLLRHTVQHHTLKRLVVTNNGQPFSENDWNRLKRIAEGNPDETKIGAFGVGFYSTFADCENPFVSSGKEAMAFFWKNNSLFTRRLQLPDSETSSDTSFVLDYRDTTSPVPPLLPLAQFLANSLTFVGLENIEFWLDDWNLLSLRKKTSPSYEVPIPRDIEPKTSEGFMKVTKVSKEIAQIDGSWMTVIGWKAPKTIAHSSTDRDAAPSLRKFFSRLAGAVQEETRADTKPDGPADTDLLATKVSATVFLNVNTATIKTFTGVKFNEELERATKKPPPKYTKLAILTAPYIEDSSLAKASAAGDVFGTVLPSRGGKIFIGFPTHQTTGLSAHISAPSVIPTVERESIDLNARYVRTWNMEMLRAAGIVCRIAWSCELQELKEKTQREANGRSKIRMEQVSPFLDEAITTFKNFTFRESTPSASIGSLLEDAFWTCSKKASIEVVSTCGVLPTHDVRIAPKDLSFMSGIPILPEKLASEANVFVSKLVDFGLLTEVTVTDIKLALESSPLTTPQVSEFLGWLTKQATQGRLDKATISSLLAVAVANDDSPEGNASPLLQLGEIRHFLNPSRTPVDFPVPPTVMPFKFTKGMSKHELESLGWEELQLVTWVRWLIAQAGNRQVLADNQDITKSAEFSSQVLPLLSKQWDSLSQPSKTALVEILVKHTVIPTKFGMKKPGDAYFPNVKLFDDLATIDGLGNVKDKFLLALGVRKTVELDVVFGRLLALEPKSAKAVTAAKPQWSHVDLIKYLASVRDDIPGADIQKLRSTAICPKQLDGRDGGESTELYNVSELFEPRHDLRQLGLPILAWPGAYRTNTPEGRFLNSLGLRTTPLVSELVQIMAEAGKKGPTYDLDRRDRALAYFLSHHHGYGYGTFDYQSITVPFLPLENKPNQLATPARCFADEGAALLGFDILKRDWTPHAPKFGVRQHPPMDQCINILATQPPSTYNDARVLFSYFAGRLGEINTNGMARLSDLNFIPIFVKGKEKSAPKGHTSPRNCFLGESEAFGEIFHFVDFGAEANSFLIKCGCKQEPSKLEIAQILVKEPARISATFRNAEKYMALLRSMAEATKTLKKHKDLWAEMRRAPFLLASRELPPTSPVAKHAGHADEADHLDEDEVQGIREFQLCSAADAIIIDDYLNYNLFKADILAAPQEESLEDFYFALGSPLLSSLVEEAARHGPRAPDQKPAQKLQKQILERSTLFLHEQPSDTIKHDAKWLEKNLQVQLVSSISLRRSLRGRNVSHTEKRTAVITAVNKEYTLWITGAKPDLYQVSQALVHILLTRPKLHSAITLEMLLKTDLLDLRARGFNVSRILRQKAAEARLAESKRQQQLEEQQKRIEEEEQAWRASQAQVEKEGGRRDHVPGGFPDSPDNRALTAPEPATPTPINAEDVRRHGRNLFSNLSRQLGFGNNRHIQQMLGDNDDGGQRALTGTSGTTDPPPPYQYNQQGDQAQPKPTGGSVTAPHQLRENLLTAIKKSRAHNSSDIFSRGETNVLQETKSYCDEHPAHDLTFVAEIKHGINCYLAPSSVSNSSQFLQQHSFGLTSFANLLNSLADVFSLGPQTLNIFFETSGKTIGFNRNGSIFCNYRYFEQLHERNIVSQGTGGEGYAEAFVYWWVILCHELAHNLVGDHSSDHSYYTEGFVAQYFGRVVRVLGQSQGQAQAQQLPVRGREGEGSHAPLVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQE8</accession>
    <name>A0A1C1CQE8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pbn1</name>
        <name evidence="12" type="ORF">CLCR_07037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQE8"/>
    <dbReference type="STRING" id="86049.A0A1C1CQE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07037"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05292"/>
    <dbReference type="eggNOG" id="ENOG502QS8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042322">
        <property type="entry name" value="Pbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533:SF1">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT50729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="533" mass="59633" checksum="D4464B09A2BE0E66" modified="2016-11-02" version="1">MRRRSTYVTHPSRAVDPADIQVRPRQLLLGGLKAAREERLTFGLEELPAELADHLRQCHELHIRWAPERTYNTTAPFLSRISPGLHVQYTPLNETQSDRLCDLLHRLFGKQLRCDSPNATFISPPLVSERFAQTSALQYYSSLPSLKYLVAYIYRTGCAPDDLQCLHTVSLLNLADSVDADYDSISHALTFTVFWSKQPPVFYDPIGDFTTFDAWNLDVQAKGDDRVEVGILSAGKANEPSDLQLSGFLTVVGEDDHPKATLFSFPSRHHSLNQDQSRAQKYTVSFDRPTGLHPTLRISFPSASSLVEPVNKPADSVCALQTYLTLPSHIFADKYAFLSNDPLFQNSHHLGQLHTIAGETDLEAPDYAVQKWGSTMLLSIQTPNHTLGGARSSRRSWDVTIPLHLRYLDPNDNGTSEVDVPWPIVFWACTAEDGTKFPVNPFDRTQLGFDGLFGPRTMFYHLGPAPDGASSGRLVERISIPVLNLEATSSWSIQMLTIVTIAFGFLWVLMKLAPAFWPRATADKQAPDQKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQI5</accession>
    <name>A0A1C1CQI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 2OG-Fe(II) oxygenase family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_07150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQI5"/>
    <dbReference type="STRING" id="86049.A0A1C1CQI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07150"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05275"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00833">
        <property type="entry name" value="POAALLERGEN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="300"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT50745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="456" mass="48529" checksum="A3754D636350AFA5" modified="2016-11-02" version="1">MATLVMPPQSGPDSLSKRSTPSILEEVAASQDHLRRRLAGALTKPPRNVPPESLPSVPLIDIGASFSGDDQAKAAIAQQIREACVSTGFFQISNHGISAEAMSGVLRQAERFFHDLSPAQKHELHVKNSPLFRGYEPADFSFVNPDDMGKDGSGHARQQETKEGFNWGYEPGLDPTGGDGKYVELDGQSPTATAAAATATTAATATTATTGLGNLWPSEASLPGFYDAVKLYYGQVLQLARHLFRLFALSLGLEEAYFDPVVTHPGGIARLLYYKSQPATATATATAGAGAGAGAGAGATADAATTNGAHREGEGNSKLGLGAHTDYECFTLLLSSSNPGLEILFPPSPLTDDKPVWLPCPVRPGTLTVNVADFLMRWTNGLYKSTIHRVVSRPGSGERYSVPFFFSINYDADVEALPEEVVGKSIYRPMKAGEYVLERLRATTTTTTTMATMTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR26</accession>
    <name>A0A1C1CR26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_09274</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR26"/>
    <dbReference type="STRING" id="86049.A0A1C1CR26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09274"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09577"/>
    <dbReference type="eggNOG" id="ENOG502S3BD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14603at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT50933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="125" mass="13307" checksum="BCF5202992DB59B8" modified="2016-11-02" version="1">MADDTRQADTGPREAQDQADTRSIRRPKPRHDFPKTQAGKMWEVLGNPAEPANALPGGTYNSAGGRPADVTWKDAFSFKHEGNGYAWYQAPCARDSLLVGMGAGGAVGGLRFILKGAVLVLGYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR71</accession>
    <name>A0A1C1CR71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_08392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR71"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08392"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09646"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT51007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="57100" checksum="69C749F2C3515776" modified="2016-11-02" version="1">MPSDLPHLDLQQQDHHHHHHHHPLPHLPLQQSPSNTDAFRGELHHLDITAQSLRAEKAALLTRLQVVREKIFANDNHIRRTMENLSSELFRSQRAERQPEFQASMLNKDNFIEGMYYQMQAQPQLLKAIHAVTKEEGTVQDNNLIAAAIMTELTGNTFQFGHDVAARVTEFEKAKNESLAVMGQPVFDGVNAFVDPTFAVTDPALEDGAAQAIQGPSASPLGAARDMSIVALMSPSVKSEGASIATPFNVANSFPDLTAAALTNTPANVALSIETTPVRQSPRATVVAQGMTSLQKSFPGLLESIGPANSPPRPRSAVAAVAGKRGRESVEPNDSPSPSVLRVAKKPKNDKEPAISHTFINYMKHLEQLHRAGKSISSTIRCSRCQQIKRDVRVLNCLHLYCHRCVLQLRGQAQHGNAVTGFQSTCVKPGCNQVVSGKTTVIDSEIVDFLQWYDQQSPVITSKVCQLHVLNTASARYPDDDGIKAKLQQVQSQFRAAHNAAVGDQPVDLMVIAKLCRKPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRC0</accession>
    <name>A0A1C1CRC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRC0"/>
    <dbReference type="STRING" id="86049.A0A1C1CRC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08778"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09659"/>
    <dbReference type="eggNOG" id="ENOG502S8GG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34557" checksum="DE6AD1EEDE177F2C" modified="2016-11-02" version="1">MEIYGMLGEKLGTIGKDKTHDSGQPEEQNVPQWKKDFLQKPSISSRNGIAWGYGTPYEDTDTLVLTSTKSDFVDIRFPRKRELGKPIASDPSFWAFSGTSSTTFLGVDGIEMRYSAHCVWEHEIDSKGPGISDEGDMFLLPNGDCMEVGMMQNPQSGKVEMYKEYWTSPDLAGEPELELVPSIVAKIIQMPNDHDGQAPSLQNGNGGTIIRIGNYCQGIVRQQSGDREGQPAGADAVLVERWTRGIFEADRTSSTAAGGEQVLAASTGWVPDWRNNTPSDTGISMPCRWVCDDNRKLGDQIVVKGATWEVVEGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRN3</accession>
    <name>A0A1C1CRN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD dependent oxidoreductase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRN3"/>
    <dbReference type="STRING" id="86049.A0A1C1CRN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08538"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06913"/>
    <dbReference type="eggNOG" id="KOG2852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF185">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="178"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="470" mass="50441" checksum="744016B5900BC26E" modified="2016-11-02" version="1">MSTIIIGGGIIGLSTAYYLSLSRPASSTSGDIHIIDSSASLFTSASGYAGGFVALDWFSRPVASLGALSFRLHRELADRHGGDRRWGYAGSHVYSLSESDEEGVEGKGEIDPPGTDAPEGQGEDWIAEGTSRARVAPMASTSASTSTSTSNPDPAKTPPTVWTRRRGWTFETIGRPGDCAQVEPRELCEFLLQECKKRGVQVHLSATATGVLTDDEGALKSLKLRYTDVDAGQSHEQETQLECRNVVVSAGAWTPRVFSTLFPQSKLRIPIEPLAGHSIVVKSPRYRTPYVDLTERERGSDNQKSMCYAIYCGPGSRWSFAPEAFARLARGGETEVWVGGLNDSTLPLPELSTDVKGMIDQRSIQDLRRTTVELTGLARGGGQPNEDDLETIREGLCFRPISHRGTPLISAIDGKDLGLRGLRTGGSGVYIASGHGPWGISLSLGTGKVVSEMLMGQKPSADVRGLRVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS26</accession>
    <name>A0A1C1CS26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS26"/>
    <dbReference type="STRING" id="86049.A0A1C1CS26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08229"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06814"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="543" mass="61290" checksum="331E3C391DB7BFFC" modified="2016-11-02" version="1">MSSSIGFVPLMGVTGIAALLVGKYSENIGTATALQVSLLVATVSYVLYCGWIYPLYLSPLRHIPTVPGFPLWGHFYTIITSECGVPAREWHQKYGPIVRYFFPFGSERLSIADDDAIKHMTVRNPYNYPKPERARKWMMPVLGEVGVLLAEGQAHVAQRKALTPAFSITSIRSLMPIFWTKSLHMAELWEQEMTDEKTESKAIEVLEWLNRTTLDIIGRAGMGTDIDSLDNPETPLRDAYRRCFSFDLEARILNGLAAFTQLVRILPARTNRDIVVARNIILSRAEAIIKEKQANAGAVQKKPAQKDIIGLIVRDNMTASKEDMLSIETMRNQVMTFLGAGHDTTATSVAWTLLMLAKHPDVQNKLREEIRSHMPFLFDPDARQDTETIEKADVDLLPYLEDVCKESLRYIPSIPMTVRRTIADDHLGGYFIPAGTVVYLMANAINHLPMYWGDTANKFDPSRWKNLPSTYTTNAFMTFLQGPRGCVGRKFAEVEMKTILCSLLSKFHFAPDTSVQDPEELKMWRLVLRPRDGISLKVTKLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS85</accession>
    <name>A0A1C1CS85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS85"/>
    <dbReference type="STRING" id="86049.A0A1C1CS85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07926"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06720"/>
    <dbReference type="OrthoDB" id="3363151at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1142"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1190" mass="129478" checksum="E549B38D2FA81BC7" modified="2016-11-02" version="1">MPVKYADPSDDSSTSPSSHLVHRPSNSVGSFRVRKHTRFKNEDESERWGIRGPLRHSSRSSRDSRGRESGSVRVHSDLDTDGVRDSRSRCSGANSTVGTNPSRRPRRSHNLGTVLEVPSGQTSRRTTIFNGSKSKQDLANRLDGQSTSAERLHAQHSSACSGMHQSVKSDDYLLSRGANPRTGVVTPSHSASSSLDDYTAQTQTPRRPARWRQKSDQWISLDLGEPTPISTNATEGFPEHQHQPLRIPQKLVAAKPSHSIRGPSLMESRDTPLNPLDPEMSLRTKERPIENSLSLNENPYAHGHSVLPQTYRLDPSVKRKPVGSPPNRMRDRAAHTQDGSDESTDTVLRMPRLNDGQRSSSAPDAPKGGFLNPQNVNKDLPKVPYDSALYGTQPATVSDPFLGARGMGQPANVRSSGITNIFSPRMAEKELPCLPMNSGPSQSTRNSPPYPTSPTETAADLMEGRQRSKLDPPQGPREDGDPAYLYIRPARPICPIPPPAENQHPLGERTMPVPVYDNPPRHPSPFVRITGPRLEGPRSMPPPEMSVLEKTRLALNPLLNTTTTPTGIFINGPGLPVPLQVGPRQMIPDLRMHRGHHGFLRRPAPQSDSGIIMNTAMNISANSMMSTPLPRIRPRAMARPARPARAEGMYGVPKVEHRGRCDMTCRDHQSRRMLTPIDTVSTTGIPDGEPVVMPEALKPRVEASQVLPSETKTLPEKAEVTSTSCGLMRKCSRCIHGFVDVKLHNTDSVIHTSDLQKDAAEAKEGTKPLHPYRSPLPVLPEDPTFCKEAIAQQDLTTPSHGKSESDERDHSICCPRCCKLDCHEGCLGHPSPTSSPSPANSMWSQAQTTGGSIEVSALVTGTEASANAKTDKLEQVSKIKGLDIAKTTRKSPPRMVQESKSDHRHIQAALSKLPVEPSVQTPTPAIPSTLNVLRRQTDAVAAALNASKSPGPAKTSAAIPAAMSAIGLTQQQVTLARPNIHRRQRSNSLPIVGLGITSRNASGGAESSRAVSGSRLRIPSPIGLALGCSAARNELFWSRNVSGTSTNTIEVQIPNLTSYTALHEIVFVPLEATKMWVKTHPQILTIGGDLLHRAWEMAQVMTKTASRVWAIIFVYSKTGKVRFHMSKGETVGGLMMDMARSLLYLLVFAAVGASVLRILGVILGVLRVGVWFCRGVFWLVRGILGVGSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CS88</accession>
    <name>A0A1C1CS88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Disulfide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_08099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CS88"/>
    <dbReference type="STRING" id="86049.A0A1C1CS88"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08099"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06729"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651015" evidence="7">
        <location>
            <begin position="20"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="676"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="256"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT51357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="731" mass="81809" checksum="D12809263B8B6988" modified="2016-11-02" version="1">MRPALLAWALAAAFSTSIAAPPGSKGGATTLSDDAINGETPAEGGEAVDYTVFNGIKVPPMKEIQGDEFAETIKDGYWWVKHYSPYCGHCKAIAPTWQTLYEFYATSDPLQGMTKSGQPDLFSPNSFHGYYNFHFASINCIAFGDVCDKNGVRAWPTFLLYKDGEFVEKYTGGRSMSDFSNYVEEKLEQIKPGSRPRGGVHVPQPGAKGVDRTAEPDAPLAKDKDTAAGAAAGEKQNKVAAAESETTTALLASETAKSGKTLSAKPAVQPNPKGTSVALTPESFQKLVTTSQDPWFVKFYVPWCSHCQHLAPTWQQMAKEMEGKLNIGEVNCEASPRLCKDAKVNAYPTIYFFRGGERVEYEGLRGLGDLLSFANKALDSDVKHVDAAAFKEMEETEEVIFVYFFDDATTSEDFAALDRLTLSLIGHAKIVKTDSEILANRFKISTWPRLLVSRDGRPTYYNALAPKDMRDFRRVLTWMQSNWLPIVPELTATNAKEIMDGKYVVLGILSRERPDEFLQSRRELKNAALEWMDKQTQAFQLERQELRDSKQLRIEEAEDRNDQRALRQAKSRVISITEETFRKQVAFAWVDGVFWERWLRSTYGVDVSKGERVIINDEDNRRYWDVTDSGAYIMPSRTSILETLPRIVANPPKLTPKSTIGAFENIFFQIRNFGTYHPYLSFGVLLISIFLLFWVLKNGATIKKSLSRTSSGYFHLDGKEGLLGTTNGKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSW8</accession>
    <name>A0A1C1CSW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerases I, II, and III subunit RPABC4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPC10</name>
        <name evidence="6" type="ORF">CLCR_09392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSW8"/>
    <dbReference type="STRING" id="86049.A0A1C1CSW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09392"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06498"/>
    <dbReference type="eggNOG" id="KOG3507">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT51600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="66" mass="6945" checksum="38E491635885F304" modified="2016-11-02" version="1">MSSQSYHLPTQGSGFATGAAAGEGAAGPLVSYVCGDCASKVQLSKGDIIRCHMCGHRVLYKERTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTG3</accession>
    <name>A0A1C1CTG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asteroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTG3"/>
    <dbReference type="STRING" id="86049.A0A1C1CTG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08209"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06322"/>
    <dbReference type="eggNOG" id="ENOG502S2DC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5297549at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18675">
        <property type="entry name" value="PIN_SpAst1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039436">
        <property type="entry name" value="Asteroid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12813">
        <property type="entry name" value="XPG_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asteroid" evidence="2">
        <location>
            <begin position="160"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="654" mass="72639" checksum="CEDFE7B2222B0BB1" modified="2016-11-02" version="1">MGIQRLLQDLLPYAERVVLGASPRSATETTHVEALIVDGPSLVYFVYNRLLAYHCLNSLTSFALPPTYDEINQGVRQVLDDLQTHGITIAHIFFDGGLPNSKREVRLDRMEKVRQQLDVFRKAHADFPPFSASSSGVRDFEKALWETSGISTRRSTLPAPPFMVASVIEALSAADSPWSSRVHIVPGEADLYCARAAQASAKVAILTNDADLAVHELGERGCMALLHSLEKRQRRSATKGLEYTVLCLAPAHTASRMDVDSLFAFGFERFLDSSVSTAVIRERAREPSSLDRMRSEYNTFLEEFLPSMPADTQLKLEGLDPRTAELIVGLDDSPHLYLTPIFEDPQRDSSWLYGADIRHLGYTLLLSSTRSRNDTPRQPAACVTEYARKGQRIASATVTGLKPADTIPRMAELEALLAIYVPPSSLGTAVSDTTTLLAWYALAIWLVHQEKVRLGKSPITFAQVVRLFGLPQMAAFPFKTPPRISWEAVHLLANIQAVLYSLRMLYQITRYIMNQLQHPSESATMASSDSGSVEGLSTGIATFHSTLSNMPPIADLFLDIPHLRWKLSEADIETRNLTIQRLRAVLEPTSQAGPGIHEAVCDEGYQDTSTEHDEAVWTSAQAKRKKRKGRRQLETQIIPTKTTNIFRLLSDDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTI0</accession>
    <name>A0A1C1CTI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08912"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06300"/>
    <dbReference type="eggNOG" id="ENOG502SM3Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="537467at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="296" mass="33427" checksum="5975D4B0026B42F5" modified="2016-11-02" version="1">MSWMDSWSRPGKHAAVPPPFYLTQGDEVPYCRTCGRVIKRVVDNIRGSRKQQQQKPTNTIKYCSDRCRNRKPGPLDKRIESTIVALLNAEPGYGVDKITAKAKVTKGDRRIIVTCEEIEEVVFGSKHDPSKTFGRKKNRASRALGEDGEWKSVDMEDDHDTGSDDQGMSPVQDKHQRVRPLVRPSQLASDVNGSVGGEKGWAERQSETPEELEKRLEGQQRAEQREMVRRAARRGVVFGFAVDSSGQDRQTTVEGRADGDRQRSQSETRRKCEALMNGSVVEPSFAKGNWAIRWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUD1</accession>
    <name>A0A1C1CUD1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase,short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUD1"/>
    <dbReference type="STRING" id="86049.A0A1C1CUD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08496"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06043"/>
    <dbReference type="eggNOG" id="KOG1199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="330" mass="35280" checksum="E56BD9A28A9A318D" modified="2016-11-02" version="1">MAEIQIDQPTLDSVRGKVVVIAGGAQGIGAATVSQLYTSGAHVFFGDWDEKKGSDLADELRASASTSAGSVTYLKVNVREYQSLLSLFDAAYNQHGHVDMAICCAAVTERPGYWEPDLLNLESVRETPTGIADVIDINLNGTLYFARLAVAYLKEKHAFDRASTTAESINSSKCITLVSSVAGFKESPGLFAYSAAKHGVVGLMRALRPFAAPLYGLRVNAICPWATDTQLLSGVRAEWVKNDMPMNQPSDVAKYIIQVTASPTAHGKALFVTGGNAVDIEEGINRTEPQWLGEKNSRELNAGQVILGLGMDWGHNGPKSAESKTNGTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVD1</accession>
    <name>A0A1C1CVD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">ADE6</name>
        <name evidence="23" type="ORF">CLCR_09449</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVD1"/>
    <dbReference type="STRING" id="86049.A0A1C1CVD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09449"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03859"/>
    <dbReference type="eggNOG" id="KOG1907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000024">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="21">
        <location>
            <begin position="35"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="20">
        <location>
            <begin position="176"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="19">
        <location>
            <begin position="444"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="22">
        <location>
            <begin position="675"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="19">
        <location>
            <begin position="870"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OCT52463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1390" mass="150894" checksum="0854478B8C6870BD" modified="2016-11-02" version="1">MATPQVCIIPGVSAFSEFRRQALASNIGARDVQGQYIHYVEPAGCLDSESIALLMKLLTDGHHEEAQEKVDEPSKVLHVLPRPGTISPWSSKATSIAHVCGLRKVVQRIERGIKITVFLEDGQSLDNASLDFLYDRMTETISSDEPDLDLLFLHQEPGTLGTYDLYNGGNSPVEILRDLNRKLGLALDDSEIRYLVEAYSKDGPVPRKPTDVELFMFAQVNSEHCRHKIFNASWTIDGKPKTNTLFGMIRNTHKQTPEGTISAYSDNAAVLEGSSGSQWAPDDLNGQWKATKEGVHMLIKVETHNHPTAVSPFPGAATGSGGEIRDEGATGRGAKPKAGLSGFCVSDLLIPEHRQPWELDYGKPHHIASSLDIMLEAPIGSAAFNNEFGRPCTTGYFRTLLVDMKTGKDSSEVRGYHKPIMIAGGVGTVRPQHALKDPGIVSDGAFLIVMGGPAMLIGLGGGAASSVSSGEGTAELDFASVQRGNPEMQRRAQEVITACTALGSHNPILFIHDVGAGGLSNALPELAKDSGLGAEFELRDVDCADKSMSPLQIWCNEAQERYVLAVAQEGMNKFRSIAKRERCEISVVGRATKRQVLRLTDRNHPANGYDQQDPIDLPMEVLFGKPPKMTRDVTTRKVELPGFDTSLTMYAPQASTDGLLEEAISRVLQMPAVGSKSFLITIGDRTVGGLTARDQMVGPWQIPVADVSVTATSLTTGIRTGEAMAMGERPTTALISPPASARMAVAESLMNLTAADLPDRLSQVKLSANWMSAANHPGEGAGIYEAVETLGMYLCPKLGVSIPVGKDSMSMKMKWSDPSSGEAKEVTAPLSVVISAFAPVLDIRKTWTPQLKRHNEVGETTLFFVDLGLAHRALGGSMLTQSFKQIGDEAPDIRSVSLFKDFFDATQQLHEQDLVLAYHDRSDGGLFTTLVEMSFAGRCGIEIMINDICPTPRTPDVISCLFNEELGAVFQVRKSDENRFKACFATCGPPPGLIHKIGRVSTKSSQQNLAIYHGGKLIYRTTRAQLQQKWSNTSYWMQQLRDNPACADAEYKGILDDADPGLSYNLTFNPKENINTYRASLLNYVRPTARPRVAILRDQGTNGHAEMAFAFDAAGFTAIDVHMSDILSPSAHQTHLGVDHDLSSFVGLALCGGFSFGDCLGAGQGWAKSILFHPATRTKFKHFFERKDTFTLGVCNGCQVLSKLKELVPGAEKWPSFERNESEQYEARVCMVKVSDPPPESGMPPSVFFHGMAGSSLPIAVAHGEGRASFTTDTPRSVIPLGSRKTLDAQMAHDFAYANLAPLRYVDNHTLAPTTNYPANPNGSPAGIAGVRSHDGRVLALMPHPERTVLGGIGSFIPEGKVLDEKGGFGEWGEYGPWMRLFQSARRWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVU3</accession>
    <name>A0A1C1CVU3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 zinc finger domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_09700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVU3"/>
    <dbReference type="STRING" id="86049.A0A1C1CVU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09700"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04039"/>
    <dbReference type="eggNOG" id="ENOG502RZ6Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="671"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="732" mass="83138" checksum="181E8F0E4D391C86" modified="2016-11-02" version="1">MPKERQTCTECSMRRQKCDRNLPCGRCVKRGDADKCTREWPEGGYDPRKHRIYPRTSTAAQASPASTPTSPRTTQINIPESAVHPSLRTPKSVNSGPSPRELPPAHPIVFNPQPTNGPEQVADNTAPVLEFLTWGRNKLSDYDLKALELLKEPHQTGNAALPKDTGSDWDISNGFGGTGAAQVSFLQLLLPNRKQVFQLVEYHVSSVLWYHGCFYGPTFYDELKEVYKGPSGMQVRNMDLRWTGLLFAVMAASMTCASEQMAQSWGFKKNERAKLTRQWYKATVTCLNLADYMWRHHVYSVQAITTLTMSAHILGFSNTQSTLLGAAVKIAQGLGLQRLGPEDDTNTASGTLTPSAPAQRDRVIRRETGRRIWQQLCIQDWFSIPFSEMYSIQKLHFTTLKPIHCDDDTMELLPEDVPSMTSFPTFLCHIAGLMPQMHDAIISSNTLYTKYEQVLDYDAQMRSLATEGLPRFFDVREAIQPEWPAWVPWARRSLTICFAHKIIMIHRAFLGRSFTEHTFDFTRRTCMAAAKTILKEARQAYDEEGPMLWIDQAFMVAAGITLALDIFHRKPNEPEFEEHRKLVENTIFLLGKFENSMIAMRGIRLLSSLLAEQARLTADQTLENYRKRTHDSMSGDRSQPKRQKFNVPKFVENFVGNDSFTHSLRTANRGVEPSLELYEPTDSRSRTPGSQDPMPNSDLGYETFEQLFPPHTGISNNFLFEDLLNFDIQEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVX0</accession>
    <name>A0A1C1CVX0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trm6</name>
        <name evidence="8" type="ORF">CLCR_09746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVX0"/>
    <dbReference type="STRING" id="86049.A0A1C1CVX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09746"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04008"/>
    <dbReference type="eggNOG" id="KOG1416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="663" mass="73709" checksum="EBE5AA034AF478DB" modified="2016-11-02" version="1">MAFSAILPYQYVAIRLPSDQIQVEQTIPNTLISLGKYGSFRTNQIIGRPYHLTFEILDRNEAKDGRELRIVPAAELHAATLVEQAETDEASTPFNETEGPATPQQPRKTNMNTHDDPTNQKLTMAEIEALKQNSTGSGRELIEKIMESHSTLDQKTAFSLAKYTLRKHKKFLKRFTVLPLDVVTLVDWMFADREFGKIMEMRNEAVGLIGCWANVHAAGEDEALLDVRPSSRYLLVDDTGGLLVAAMAERMGILHQTTLEAEPIANAGEVASDTDDQHSPPANQFPRPSRQQYPTAMSAQSNTITLVHANQQPNLGLLQYLNFDSNNPNASHPLYTHLKTLSWLQLLDPETDIAYKEPEVISGQELATMKSNRRSAYYRKRRRWERVKSVVDETRAGGFDGLIVASFTDPTSILRHLVPLLAGGSQVVVYSATVEPLVELADCYSTARRTAFINSPADERSVPSRNFPLDPTLLLGAMVQTSRVRRWQVLPGRTHPLMTGRGGAEGYIFSGTRVIPAEGKVEARGRPPRGKKAKAEENTEDASRETAGQELFDSVKDDTMRSPIKRQKIEEHISSATEGGVPVPLTKPMVEENNELEAQLAAERQFIDSAREESGQSPLEAEKVVELVVQEAEEDEMPVLGPATEALKEEMDEKDDVQMSIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW74</accession>
    <name>A0A1C1CW74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW74"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10850"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="84" mass="9541" checksum="21290B54D5EE7601" modified="2016-11-02" version="1">MQRFVGDLRSTPQLEQQSTIPTPQKEEDQHASNHCRQHTDKQTLAMALPLAINQQTTVFNVPNQVVVEEAEDEDADSPNRVQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX56</accession>
    <name>A0A1C1CX56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX56"/>
    <dbReference type="STRING" id="86049.A0A1C1CX56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10869"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00076"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00077"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="14"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="162" mass="18210" checksum="CD88C322D4EA20D3" modified="2016-11-02" version="1">MQHRSNARAPPIAEAEWDRHRSVIEGLYRLHELADVIERMERGHGFHATEKQYKRQFARWGIRKNFSSNDMKGVLGRPTENAIVRGVQVPKAKITRFERRQRLKASTTNRDQIRVQQEDLSRLQRSIDSPSSTGAALASLSRHAGSENSLTGGGGASALSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXS4</accession>
    <name>A0A1C1CXS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXS4"/>
    <dbReference type="STRING" id="86049.A0A1C1CXS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11399"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00287"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF135">
        <property type="entry name" value="SET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G11040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="706" mass="79411" checksum="0626F9984C3C541D" modified="2016-11-02" version="1">MEPDESTLEQDIVNAGPQSTTPPLQMSERHAAPAEGVFDKHRHLVQWVLNHDGYLDPNAQIAFSPRKGYHAVVADGATMANGTRIASCPMTATMSVLNALDIEPFSNHGVEFPKPFLRAQCRKSPECLQAFYLMEQLILGITSWWAPYIATLPTVDDVTAMQFEEEADLTWLNGTNLRAGLSTQTAKWKEMYLQGSSELRQLGWANALNGSYTWPRFRWAASIFGSRSFTSQVLDATLPADLARLKRTPQQYESYDLVKLFSDRFGVLLPLLDLLNHKPGAQVEWQARYNFVGLQILEPYGSGQELCNNYGPRDNEGLLLAYGFTIENNPFDHLVISIKAPPASPLDVARKTWKQDLRSDPERRCFLFDYKHPESTSAIALELSLFSFDLLDSISILCANEREMQSMTTRRQSLMSFCLHNKSARFEDGRIILAVLSQLLRECSVRAERLRATDPSRTVLGLKPANAKQRHAKIYRDSQLEIVETAVALCKFVLRCAIGGTSGDEQMLVGLQNEVPEAAFGNLKTLVGRHGRLTRPLELLDCNALVEMVPDSDRLWNCLTELEQHLLTAGALPDSKSRLAVALSALYSEYSHGVKLPHRITEWVKQLLAWYPVDPTSWAYVPPPGPWEPGEEPPKELMSLLSARELMSPKMPAESAVKRWLKPERLCWGWNVMEEEKVPVPSSIAEPEIAGSHQDGNSTLIYWQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXU4</accession>
    <name>A0A1C1CXU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXU4"/>
    <dbReference type="STRING" id="86049.A0A1C1CXU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10507"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00307"/>
    <dbReference type="OrthoDB" id="4119398at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="333" mass="38185" checksum="57A959085891205E" modified="2016-11-02" version="1">MEGSGTDSRKQAAASNDRASTASLVDQLGVSAPRRSTRKPSSRPPKFLNAMDRRTENGMIVPAPPPVIRTEENDPTPSLPSVVAAVQRKNHHKTKLPPKKKQKLDTNEQAQPPPPIKPKAASKRDPKLPETPAQAEKWDKMLWEKKLEGKGWWEIAEDWERLTDTTTEITDEIKESDAIIKRRQLIDRLAVRFVMLKENYAASGTMEASCPSSLTPPMLITLRAQLPDSYYEAHPYDLKYQYISNRKRQDVKLIRIMDKTKAQLDEKLWETFCRNYKEDEGLEISVTEARRRYEVLMNGVMKLKPTASEEKDMIKVKKEIRREPVAIKHEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY93</accession>
    <name>A0A1C1CY93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative fermentation associated protein (Csf1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_09413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86049.A0A1C1CY93"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09413"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00398"/>
    <dbReference type="eggNOG" id="KOG3596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006113">
        <property type="term" value="P:fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029636">
        <property type="entry name" value="Csf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056779">
        <property type="entry name" value="Csf1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048636">
        <property type="entry name" value="Csf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085:SF3">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25038">
        <property type="entry name" value="Csf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21678">
        <property type="entry name" value="Csf1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 N-terminal" evidence="3">
        <location>
            <begin position="157"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 C-terminal region" evidence="4">
        <location>
            <begin position="2498"/>
            <end position="3233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1312"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3130"/>
            <end position="3153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="3234" mass="360645" checksum="364D00C3CAEADE7C" modified="2016-11-02" version="1">MSDNSALVGEPISRNTSFNWTWFVELATASCLTLFFLFYFNRLFATLVSYGIRAWTWHKYRAWIDIQALQLSFLAGRVFFKGVRYHAENETVLIQSGYITWRYWQSSSRQVDLSDPDEHEQNPTQTEKKGSTVGGSDESEPPLTDPESGRVRKKDTAGARISVFIAGLEWFVYNRTPVYESIVQDVLIHELKHGSSDSQTAGHQHEHKLPKLHHRKDATRPHSKDAATSDDSADSPLGEKNEQQSPLGEFPVPIVRADTFTSVASGVDVPTADVPSFYGWILRVLPVAVECSKGAISLGNETTRALVVTTFASAKGHIDAAAARPSDYFRQVFDFEIEKPKVEMRPNPDFRRSQFVAAERIILAAESLRHRPRWWHVDLGVRRRVVKTFHSLKRLLPGSSRGSLRTTASQEDYDRKQYAYEEFQDDNRSWHGLGRYMDEDERDDHEGWSHIDYARFSQILDCPGVHFRFFWDMPGKVMEEHAESAAQTNIDDINMSKPPAYGMDLIVKGGDVNYGPWADRLRLEIQAAFFPTPYRTMTPAARVKTGEARQYTMMTIRVHLEDEVSLRVPARERSKDWQWRNRAHAVREAAAARKQREKRHFRFRRSTKTKLGPDVRPFGWLTVSAGQDSTVRYDMDMLPRAEGYINHLHLDLKNTKATSSVNHALLWRCPSQKVSCDLSNPLMWNGLHTWTFDVESNAMEMFILRDHMIMLTDLVSDFTAGQKPDYMTFVPFIYRLHLTFPELKLFLNANDYNIIDSPNDLEENAFLIFGFQTLAGDVDIPMQYFSPRQSSVQFIGEGHNASLELITPVWNTLNTLAEDTTMMTLKQLNLEGSYNYYPNVSPKLTDSLFMTITGYAPKFFLHGYLIRYFMNVKENYFGEDLHFRTLEEYQDMLAGNEPQGPRPGIKKDNDLDVILTVRADSAAVLMPANIYSRRQNLRVDVLLVEADMRFTNYYMDLQVSSSPLEASIESISLKDNQPCSDITNCQLFIDGVGVYGHRLFGAPPLEPTYACHWDVNVGEVTGECTSKFIQTLVNAIMAFIYTLDDDENSLPPFNRTAVHDVIFLRANIAGLRVWLVAGAVAYMVDLSETDISFSDWANSNFAKKLRANVPRIEVAAVDYKCALRHHDRKSGPVETYACFETSLRIGTLDKTDNLAHTRALQQQHIRYHDQRTHRADWLLDTRKQYPPNHKIPEWARDLPAMPVPAMPEPLGTPANTSFPDPVHRFGRKRFNRKSSFISVPSLRNSGESYVQRPPHPDPSTFHPPSERSAANERHSLDRLHGRDGDTHQALVTFSSPWTPPHFTLLDVQPEKSLMPQLPDPRRSDFASLTAQESEDPETKSDEFEGTPHNGVIAMVQNGLTGFCSPALFLSIGETIRELIADHPIDQLDKMQITVMKRILETHKHDDQGHVMDFAVQVPFAHIKLVNTLTKDGGFSSPNDQYDVKLTGSQMMYRLLHPKTARPGITSPHNQLAYGSIQNLSVSVRDDAFASGRPSAHAAVSLARVGFWFSMKDEVNSKLQLSNFDVVLWAEQLNSMAALIQRTVAMVDRMIGAFEGLDQSFKSRHLISHLTQAGSAIADPVFLTRPSYVLRSADKHVRLSDSWKIISRLRHIFATIEQDKGREFVEKCGCADLELKDLDKRQVLSSFEQWRGWDHARDKVPIMITLFETPGRRTPEASPNSLIVHSEIIVGKLEVILDPGPRQSDFAVLGLDFNIILRRGQASGIDGNGQRVILQAYTADTSLHLNWALVELARQLIELVNPLAQRPPRNDALVAHSKEPLSATRNHFTVVVGTDAASIHLTTINLKLKWAAESFRSAFSFSEGSSGPAVSSFTIAANTAMAKFRGPTRTLMLWRIRMPKLYGSIWPQGQNQSAKEKMIVQVCAASNRLRFQMKEELVKVLLVADSIVRDEVATIIRLVDEIPKSQNDHEKVTSTNQPSLDLNVDLRVAMFLDDYRLNFAILPSLQYAITGNAARTSIIPRRDGGLDINLDIKEHEHLFEVSQGRSMDNLPLLTMPPINGHISVVPAASLISIRARMTVEQINLEASGVRACFDALNQPGVVQLIPDAKHAIQQIQSSADRALGTRSQPSRVKKEDAALPLRYAIHGTLAGIKIHFSAPSIREDQDYRADMELKLRGTTLFMHNEMDNPASIQERPQFTLSTQGLGLGLYRSTSHARESFGTFSVGMKASGKTETLGNAGKVQVYRAWSDGLIVELYEETATLAVDIIAFLQDRIKSMKLADREGNIQHIRRLTTAGLTDRLKPKEQLSETGSDAGQSIDGSSTVLYDSTYALDLGNIMLRWNLTSGSRLSPSHETEDLVFSIRKVDLKTRQEGTARLAISDTQLQMVPKSRAGSPITRTANSALLPEVVFGTGYLSTKHERRIAFQAKGKALDLRLASDFIIPGHALQKSFGNASGELRNARAIYETGPATPQAAPIDLLGGKRLASLLVDADFAGAVVHISPRVEAENKSSAFGFLKGPKRSRAGRYGQAVQGEDVSSAVLQAPGVALKVEYKNDNKGDPSLSTEVRVAASSNTLYPTVVPLILEISASVKEILGDDQVNNAGSPAPTESRSYLSDAALSNSNPDAIFGRCKLNAGLYIQPQEFSLSCQPIARVAATAKFADIFVRINTVSAPDQERFFAILTTFNKLEASVQHVYSRESTASFEVDSIVMSLMNSRHVSATTGISAILNISPMKTDINAKQLQDFLLFREIWYPPELRGRAKPSSAAASPLDQQAYAMQRYQELSGKGTLPWHAIVSVQELQLVVDLGQGLGKSVFTVSKLWASSRKNSDSEQNLCIGFDRVGIDSTGRMSGFVELENMRLRTSIHWPEDAAAKARAPLVQASVGFEHFRVKAAFDYQPFAVADISFFDFLMYNVRQGHKHESDRLVGIVNGGKVQVFCTTGTAAQGLALVQAFERLVQEKQEAYKTSLRDLDKFLRRKSMFPSNSWTAAVPARQQKEDGPNRKGTFTLHTDVIVTLGGLDAGVFPNTFFGNQILKVEATDVQARFAVATTEGKTHSCLGMSLGQLRVALSNVNRATTKALSEVSVPDVVDRATSSRGGTIVKVPRLVSSMQTWQVADSNVIEYTFRSTFEGKVDVGWNYARISFIRGMWQTHSRALAQRLGKPLPPSAIKVTAEPPAASSSAGGSDAGGTGGEKITAVVNVPQSKFTYVALQPPIIDTPQLRDMGEATPPLEWIGLHRDKLPEATHSIAIVSLLEVAREVEDAYTRILGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYK5</accession>
    <name>A0A1C1CYK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11034"/>
    <dbReference type="OrthoDB" id="10474816at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="113" mass="12555" checksum="9100DC0D4424F88A" modified="2016-11-02" version="1">MLRGYTEASIQQRPQASNHRGFCLRCGKQPTDLVIRRLRLPQRLLLCAHISQAVCSPARKEQRQRRFPSLYPSQIGHANTSSVSADPASDQLAETKLGLEKAEDLADSVEVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0D5</accession>
    <name>A0A1C1D0D5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0D5"/>
    <dbReference type="STRING" id="86049.A0A1C1D0D5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00331"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09437"/>
    <dbReference type="eggNOG" id="ENOG502S2RN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1161823at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02223">
        <property type="entry name" value="cupin_Bh2720-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052538">
        <property type="entry name" value="Flavonoid_dioxygenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346">
        <property type="entry name" value="LIGAND BINDING DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346:SF1">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="46"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="164" mass="18145" checksum="A074E00B7CAE86E4" modified="2016-11-02" version="1">MKFPTPSSDPPKHEMAYFPDMTTSLPSESGEFRRVLWTGLYSQLVLMTVPVDGEIGDEKHTVDQILTFTSGKGKATINGVDQDVKAGDLIIVPAGTQHQFINTGPTPLILYTVYSPAEHKPTTVHKDKAQGDREEEEGIDEAPEWSQRSKKENEELGLVEPEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0P5</accession>
    <name>A0A1C1D0P5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_00345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0P5"/>
    <dbReference type="STRING" id="86049.A0A1C1D0P5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00345"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10202"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="137" mass="15092" checksum="9124C2FA34DA7341" modified="2016-11-02" version="1">MVSRGCVFGLGAITFILASAIPIFNFLIAMVGSIAYAPIALIFPAWLWLYDHRDWWKRSFKHQVAYALHWLLLLIGALVTVGGTYAVITQIADAYATGLIGQSRPCTPFPVSGADTVARVCRLCFLVRRQLQLHLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1F5</accession>
    <name>A0A1C1D1F5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="6">M1Pi</shortName>
            <shortName evidence="6">MTR-1-P isomerase</shortName>
            <ecNumber evidence="6">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mri1</name>
        <name evidence="6" type="synonym">MRI1</name>
        <name evidence="7" type="ORF">CLCR_00873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="6"/>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1F5"/>
    <dbReference type="STRING" id="86049.A0A1C1D1F5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00873"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10092"/>
    <dbReference type="eggNOG" id="KOG1468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="395" mass="41929" checksum="915A0BB6552D6940" modified="2016-11-02" version="1">MVLQAIQYEPASGNSAPALRILDQLQLPHRTAYVAVSTCEEAHAAIKQMKVRGAPAIAIVAALALAVEVGNEIVAGRLPAVPGDVRDTIAQRLDYLKTSRPTAVNLGDAVGKLKIVTKKATLQPEASSQTIAEAYILAAEQMLVDDVSDNKAIGEHGARWIEANTVAGKKRKADTSQQLQVLTHCNTGSLATAGYGTALGVIRSLRSADMLTRAYCSETRPYNQGSRLTAYELVHDEIPATLITDSMACALMDKEGDRLAAVVVGADRVAANGDTANKIGTHSLAVLARHHGVKFLVAAPRTTIDRATASGEDIVIEERAPEEVTRIKGPKVTVEGKLLLDEGSEVVSTAAIGIEVWNPAFDVTPAELIDGVITEVGVVEKVNGKFDFEPIFQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1H5</accession>
    <name>A0A1C1D1H5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_00822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1H5"/>
    <dbReference type="STRING" id="86049.A0A1C1D1H5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00822"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10093"/>
    <dbReference type="eggNOG" id="KOG0381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051965">
        <property type="entry name" value="ChromReg_NeuronalGeneExpr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040:SF3">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="118"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="118"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT54565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="543" mass="58879" checksum="4836CC5411A0B650" modified="2016-11-02" version="1">MSDLAPHLERLGLEQYLDLFISEGFDTWETLTDIQESDFDALNVKLGHRRKLQRAIAEYRGISFERLLGSAAQEGQPESGRASEAVIAGSSEAERPAGPPPEAKRKYRRHPKPDENAPERPPSAYVIFSNRIREEVKDQNLSFTQIAKLVGDRWQKLDPAGKEPFEAQASAAKERYNIQLSVYRKTDEYKEYMAYLADFKAKHGQTAEAKRPKLEPESSGSIISTKSFEAGHEGTAPPSGHFRGSSMGSSASSPFIGGATQLTGSGGPAPPRPRLPSSRSGSPPPSLQSREYFRPGLISGHSSVSDESATVKSEVPDTVSRTAGLSLGAPSATPPLPNFPPSTSAGESAPGHDPLARSRLSYFVQQQQPVSSPLSNVGISPPGHGALSYQQNFPSPTTQESSWRNRPPEFRGYQDTPRAVPMSYPHSTPGREQLSPTQLPPLVPQDRMSDYYPAASPRLLPPPRAPSSGTSSLPHLARAMEPPRPMTEPLQLRQQARDDGRLGLNRSESDAATTLAGLASGVTRPDPTKPHSPTPPRHPRPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1K3</accession>
    <name>A0A1C1D1K3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitin biosynthesis protein CHS5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CHS5</name>
        <name evidence="4" type="ORF">CLCR_02979</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1K3"/>
    <dbReference type="STRING" id="86049.A0A1C1D1K3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02979"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04700"/>
    <dbReference type="eggNOG" id="ENOG502QRF7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17742">
        <property type="entry name" value="BRCT_CHS5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13945">
        <property type="entry name" value="Chs5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000453">
        <property type="entry name" value="Chitin biosynthesis protein CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="75"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="163"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT54591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="397" mass="43507" checksum="88D1AB833A81EE89" modified="2016-11-02" version="1">MLVSLTVGKVDAGVAVLLTQDKRLIEFPSILLPSTITSGSIVDIEVKQNHEAEQKAQAAFAALQTRILNTYGINVPATPVLRLRNATQTSLVLEWDPIQLATTTLRSLALYRNGSKAGNIPRPLETLSTKMSGLQIDTEYSFYLVLKTSGGVYTSNTLTVKTHTMNNLTGITVTPGILPPQLRESLEMAIERIGAKINDTIRIDTTHFVCTEGRGREWERANEMNIPIVRPEWVEGCEREGKIIGVRGYYLDADPKQRQVGSNPSLAQARPSTTTAPQQADIPQRPKEPTPKSPDRESTVSGEPGPEVLPTPPLQKDLPPTPADDDDDEEGEEEEEEKEPNDHQEPTTESKGKGKAIDEEPADADDDDDDDEEESHEAQHPPKPKDGNGAEMEDVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1U9</accession>
    <name>A0A1C1D1U9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial mRNA processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1U9"/>
    <dbReference type="STRING" id="86049.A0A1C1D1U9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02753"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04853"/>
    <dbReference type="eggNOG" id="ENOG502QPU6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013943">
        <property type="entry name" value="Pet127"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014:SF0">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08634">
        <property type="entry name" value="Pet127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="927" mass="104490" checksum="CDD2A208E9174BD2" modified="2016-11-02" version="1">MLPRSLRHSICPPCRNDHGTWTGALVAINVLHTCCSIRHVRTRARRLPIRHSRRSLEEKRGERVEGLASKTPTKEQDGSEKPAKVDTKEGQARKKFGLHKNVKHELGVLEDFRLLMRETGMKAEEQAVPVTEPMTVDKVIALMDVKPQQRGYYRVASLLKSVYGGRDYKEVDRDLKTVTPLKRGKHPRSKILEEILSRLGFLNQSKSGQPISATSVRKTSSSAGKKTATKKKPSLLKISKVLTEGPPLPEQRSITLETPPNLLGLTPQSLLVADGAEQDGVRRQPPERSLIRRYRALTTSKGPRLAKQDRIADMRGGPVQVASADKFPLIPFPLETSEVPRLSHDLSRVLFNPGVYQLQDPRSRVWNFDPYLGNLMPVSEFNYDALNRYITSSEDVNLRTVARAKDKRYIGSTSSMSGVLAHFHFLLSGFRDLNLDHLSRGFKDEGQVNFTRIQKGPTAIFLRYKDGVYAVDADKEFDSANILMSLGRSMEKLLTSDKEEFERYRRTEDATKDAQMKSSHPEAYHYSGLGQFLLRSQLDAHDPRLPGTGMFDLKTRAVAAVRMMVHDHEKGAGYEIKERFGTWESYEREYFDMMRSAFLKYSLQVRMGRMDGIFVAYHNTERLFGFQYVPLPELDFALHGQEDRTLGDQEFSLSIQLLDHIFNEATVQHPGQSFRFHFEAREATEVSPHYMYVFAEPVTEEEIVAIQSLKKDEIRAFEDRIFNPGRAKSPKLDEDDADEAEDGDESDGVDSAPSDASTNTGFAQQSNAADVAFLDGVLGLNINEAMASAPKEAPVPEFTEEHAAGGPEATTTDTQSASAPSKPLLAWRLNIRNIVNGLPVMRPENLKESDTWSLQYTLVPLSPGEAQRHYTLCKNRRKNALEAPQETDAAANFYLNRLVSMSRSGAQWRQHLDKLDAGRERIVLYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2M3</accession>
    <name>A0A1C1D2M3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Single-stranded DNA-binding protein RIM1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RIM1</name>
        <name evidence="3" type="ORF">CLCR_03163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2M3"/>
    <dbReference type="STRING" id="86049.A0A1C1D2M3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03163"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05074"/>
    <dbReference type="eggNOG" id="ENOG502S0M8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1078367at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="143" mass="15640" checksum="8F71D75447E5B92D" modified="2016-11-02" version="1">MSFLLSPARRTASVVPSFSARTFSTSRPSQLARMTLVGRLGTDPELADTGKGQVIKYVVGSSFGPKDNRQTSWFRVASFAPEGSPQRDYVMGLSKGTLVYLEGDATMRTYDDADGKKQSSLSIVQTKIEVLKRPQSKEEEAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2Q5</accession>
    <name>A0A1C1D2Q5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2Q5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02746"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05159"/>
    <dbReference type="eggNOG" id="ENOG502SD0J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5404004at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="739"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="810"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT55066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="952" mass="102789" checksum="024AD39837B65559" modified="2016-11-02" version="1">MPARWLSIRKRNPLHPHDPDLPPSAKQQDFDFAFGEPSSAPQTDAARVGPRLVQIRPTTSGGNTGKRKPRVEVPSTRPQTTEAHKPSPLQNPNGISGSEDSFIGLAFGSPSHPPASFGAHVEAGSSPEHNPFARHQQGLRDKTSQMQSKRWRKIGTLFKPRHVLRRDEVPSGPTIGLPTGLIVLDKDPALSPDHAGQDRLRGGLPDQPTREPPPPPLEKHAKPAPRTADLPPQGPEDDSMSRPSSGTATDTGSMTGESHRRPPIPKLELAIPRNLDAAKRSSSLLARRSKTLESLKSLEDSRPTTKGTIDGGRDDGSKPDSKPLTPLKPPRRLTTPTMTRSPAVSKYSLFPTPSPAPVKFVGRVPGAEHDTLSAGQLKRSATSPARLSPMQDHFGDVSKPVPLNPRRIDPVEPYFNSPEDNTASTDREAPWSSAHSFQSSVSSATTVDEIFFDIKSFRDSKGVEDGHFVMTRPDSAQVELARTRSKRAAPASRLRQMEASTSDEHPSEPIPASTGSQSALTTKHTSVNTAYFDEAIAAVERLTTPTAGIPRGGVQPAIPTVTVADHDDKPPLPSLSKLQPSKPADHHLRLTSKSHEEVSRLIPSPVVESKEDDSPKPNASPTTGPKTQQILVAKVVSPQFAAIKCVDRPIDDSPTIPQGPPSPKRTPEPPSPSEDKPPPVPKKDAKFIPMSKYAPKGTVNAIERRSGVTPTRPVRANTEDLAVRQPSQRVSKERSATMPSSVQTQPPNQSPQSSSLRGLEKTVPPRPNPVALNPMGPAEVAIARTVSLSRKQSARVHIPGPRLAARRAEAQASAQTQTQTQAQAQAQSQQLQRQPSAHQRNPSTVSQKSNKSPKAPKGSILGHRHNRTTSSAKSTHRASKDFSSKTKVVKTPADGKSGGFGKFMWSKESEKQLIKEARKWEILEKKSYSPIVVQAEMGHRPGLSVGLVVEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2V6</accession>
    <name>A0A1C1D2V6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2V6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03126"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05100"/>
    <dbReference type="OrthoDB" id="4136839at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT55010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="215" mass="24039" checksum="781EC98FD8BE1BD4" modified="2016-11-02" version="1">MGSKYGKQIWEANMGSKYGKQIWEANMGSKYGKQIWEALLGTMLQGVAPDNSLLNQSDKAAVLSHQSWMTDHSRFDDTQFSQRQGLPLAPDGSREIHVAPHGQGNMRKRLHNEIHHLASEPIERAYTFRTLVSVWLGRSEGTVHNLSTHCAEGRLVSARRARDATPLLVDVFRSPHAPFAGLRDGLESYLITLYSRFCAATVAQEGIVCEHRVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D311</accession>
    <name>A0A1C1D311_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D311"/>
    <dbReference type="STRING" id="86049.A0A1C1D311"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02712"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05163"/>
    <dbReference type="eggNOG" id="KOG4839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1922977at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019607">
        <property type="entry name" value="Putative_zinc-finger_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039278">
        <property type="entry name" value="Red1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21563">
        <property type="entry name" value="ZINC FINGER C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21563:SF3">
        <property type="entry name" value="ZINC FINGER C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10650">
        <property type="entry name" value="zf-C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative zinc-finger" evidence="2">
        <location>
            <begin position="1320"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="932"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1195"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1400"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="791"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1400"/>
            <end position="1409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT55070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1431" mass="153634" checksum="485988E7465C8E6A" modified="2016-11-02" version="1">MAHPYSSTPMYAGTPSYAPQQQSYYPSYPSNGLQQQIQTPPGLLQQPGQGQGQPSTFPSYQQQQQQQQQQQQPSPSTNGPRFEQNSQLPLPTPSFPPFPPPPINFNSDFFKQFASGSFLPPPPPNLPPVPLPSPGYPQLSAAVNTSTSSPYSQFSTAGVQGFGSGFAQNEQTRQQHGDPYIGAQQGAHAGTEWPRDSHTYSAPVAAQSASASNPRPISRGVISLVNEKDQSLPSFGSRSDLDMLFATAQNLMGQATLAHETAVSQKIDRDDLGEHDPAIDGGASPYDPTRPATIQDRSSGSFGPTSNASKGHGPKKVERVYDNKSHTELRQLAKGAVLSLVPHKILYADLVKEGVNPQILRELYGELGLKIEPGQYKEDVSMADADGTPPAQQAKVDIHEYAVTQTGAQTGIPPASTALAASAVASKAPPPPAGVDAKRQQTAPNLSLERKDRIAQLLAAKAGRSTSPQVAQPIVTREESSLPLPVTVSTNASEVAATLATSQVAPATQPETPATLAVTGVIKPKAPIGLVKQKMEQLKREAQTRNEANLAQPSSAQASTPDRDGSVDVTESTLQLGAFTPLVASKVSSFNQPSVTSLIPGLFMSSSEAPGIAESTSQPLPFQSSSSLIPAKRSSDPNTASSAFQPPNKKPNMQQDLPHTSSIPPADNDLDYDSEGEVVEDTETDMMARDHEPDQTARREDQPQESSLATSPPSSRSAGVDQVAAASLQPASNNGPGSDQLYRAKQSEIEAMRRKIAEMERNKLKRTRSQLESPSSSKPATPPVGGEEHQPSSSPISQSLELSGSQRQTFGNRTASKLTREQLQERAAALKAEVLRQRSQRQQVLQEGLPDLNAEVKKTESRLENSRKELSRIRGQIQNLQADLNRLVVQEKELNEEVGRFEQQLKEGQEGQKQYSDELQQIKLEKLAEEQALPSQQEPVMNPAVQPATRTDSQPLPGLSNGDVASQGSTHQDDQDLLAVQLDSAAATLAEDDAQMRMEDNGENLTPDLITSSALGPTIQHGQGVQIDDVPEPPPPDRSEITPPEETDSTDAQLQAALDDQLGAGEMEISPEPEYYEESHETLPKTSMGQELTEETMDMDNDSNGSASMSGSDDEEEEYEPAGVGSSASMHEDEYEPADVDTSVPMQQSDDEGEYDPETAPIESGTPTTGVPEETDGFHNPTAVVDVAAAAPTPAVSEAPVNDSSATALNAVGSPTEGRAPIDDVSVVSEVPINTRDDLESDAQLTEVDAIVKPAPRQSEAAEAVALLGGTTTPTVHYVPYQTPFSSFKSYRFHSDFNETVKSGYRSLTYSNNIDHSRPLCPTELSGQTCNDQNCEEQHFSQLGLPDEKILVQMSSASDIKDKATKDEFHTGLKQVIADLRAHEVKDFEKVAEALSKYRRDFSAAREEKDNEPETTTKEAESSPSGGGPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6M9</accession>
    <name>A0A1C1C6M9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aquaporin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">AQY1</name>
        <name evidence="12" type="ORF">CLCR_00642</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6M9"/>
    <dbReference type="STRING" id="86049.A0A1C1C6M9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00642"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01121"/>
    <dbReference type="eggNOG" id="KOG0223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000024">
        <property type="entry name" value="MIP aquaporin (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="321"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT44195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="370" mass="39356" checksum="FECB06A49E83E22D" modified="2016-11-02" version="1">MDNINPRSGFMPGVFGRHRGPRTGATPAGADEKMQGPKTSSFFMRIPNKPRNHFIAMAGEFVGTFLFLFFAFAGTQVANTPQTTSGSQSTDLPQGPNPIQLLYISLCFGFSLAVNAWIFFRISGGLFNPAVTLGLCLIGAVPFLRGGLVFIAQMLGAMASAGVVKALFPGPLAVTTSLSGGTSKAQGLFIEMFLTAQLVFTIIMLAAEKHKGTFLAPVGIGLSLFIAELGGVYYTGGSLNPARSFGPCVANRRFPSEHWIYWVGPLLGAILAAGFFWFIKSCEYQTANPGQDFDDLEASAYRPEEDLTRPVVSPTAVIPDRSISPVASRPSKEERSGTYQPARLGSGATNTTLGPAANGNTVHDRTTVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6P3</accession>
    <name>A0A1C1C6P3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6P3"/>
    <dbReference type="STRING" id="86049.A0A1C1C6P3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00694"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01058"/>
    <dbReference type="eggNOG" id="ENOG502STER">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5350410at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="3">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="259" mass="27907" checksum="7B596C3D0F7E4231" modified="2016-11-02" version="1">MVSTTITFENDNVQPPVFIAGGFTEWAPIEMTYEATAADGSIKNVFSYKAELEPGEYQYKFRLGPGDWWVLDESAQKATDELGNVNNVLSVAAEERKAPSQPQAETIPTPPAHVLNTEDAYIMEDDTKVDGSADHEQSAQPYPPPEEVVPKLADSHAPEQPAIGAQKLSTETEKQAQSVKQAGKETPEIGTPRNDSIPDFAPPPYSVSATGAVQESDDKVQVAPVAEALPQKLPSKPAAVEDESEGKTQSLGVRPYSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6V3</accession>
    <name>A0A1C1C6V3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6V3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00551"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01108"/>
    <dbReference type="OrthoDB" id="4121327at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
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    <sequence length="1267" mass="137753" checksum="D67A2190365E3E14" modified="2016-11-02" version="1">MPSSWLEDDESEAWCAEADANAGGTDEAQRRQSSDSADVNVYVKVSAAPQQQQQHHPADTGQDEHQPSYAGVYAPDTGLHAATLNSSPLKPASASPAADISGGHLHEVLQEYSSEAEAEADVADEGEGEDEASVSVSVSVSTSGFGFGFGSGSGPGPGPSCIHRLDRHTRPSDKDSLFGDSASEATVEEVSWGKARSQSGNETAHTTVVPSAQPSIPRRPDVDVNMNTRPPSCSSPNTAPESSSPSTSAHFVSEDIGAGAGAAARATVSPPANPESLGEHGHHRSSTLLANLFAEQGWPEHDPAHPASGNGNLGWDEGQLLLANQRREARWEFQPDPAVGFEEVLGRAVVGGGNEGKGKDRGEPGALKKSKDSVGTGSGNTSLHEDEDCGGDDDGDGDGIGGGHRGEDGGDGGGGGDDDHNMDRSGHERESGRESPPDTQDSVHHVDYAEEAYHCVADDGDEKKEDDQEQGYCDDERHHEHDHEHDHDHDHDHDHHNHHDYNHDDPHDETQYQHESGRGGQHQDQNQNQTSSDDEDDPWPPPRPETIDILADSAPWSHLRDRYNPEEDDVYWKPARSPETKPKLQGFAQYATQSKPTWAPPLRPLSEDEKEYARVLYYERLKREGRGPYARDKRGPAQEGEAEQLCYADPDERREMIEETAWRAREIKRRRREVFSGEHFGKGGPHDSNLWSEEQRLYMMSTIDLEVETLVEERRAKQRREKEAEEKKMHEGEKAEGKWKDTDTDTDTNNAEGSAGERDAGSCGCPCGGETSKCSCHPLYCPCSGCDHAEQAEQLRKEAEMKWGEGEGEGEGKGDDDNAQAPTETAKQHGACCGGSTTQERCVCLPGLCSCAGCEEHHVGHGQPGMELEVEVEMEPPSTHSGLWPRIPESERLFKLEQKRVPDEDRDCACSANGVCHCPSGRCKCRKPLSAPEQWVQPREELAPLTFPRTAATWTSGQYNHPLDVGLTQDEGAQTLPDAPPSITGGFLHPTATATSTQAAVATSRRQSPIPPSRPDTPRPPADSGASTPYAADVLHEYARHSVEPEPMPPSQTDVRQSVEPEYPPPDWTRDTTPAYEDRSFTPSPFSNRGDVDMRDASGGTIVPSALGRDAPVSAPDLDPEEHRSPSPKRPHPPPIPESLIKQPKRDDRRKSAVQGSKVEKRSTTGTKTKPRSRNVTRKPTQSVGKLVEQVKKGSQDAGQAEGSFESEEPIKPAPKPGGKVAEAVRNIERQLQQQEKHLKQKNGSPVRRSARANKGVRTSSGYGSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6Z6</accession>
    <name>A0A1C1C6Z6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_00543</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6Z6"/>
    <dbReference type="STRING" id="86049.A0A1C1C6Z6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00543"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01163"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="12">
        <location>
            <begin position="847"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="528"/>
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            <begin position="999"/>
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            <begin position="1842"/>
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            <begin position="36"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="11">
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            <begin position="129"/>
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            <dbReference type="ARBA" id="ARBA00008926"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT44241.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1936" mass="204684" checksum="7AD5EB82AB301B06" modified="2016-11-02" version="1">MSKWGKPSPISKRNAPIYFSRSDDGDSSHKLDSDRLTTSSAGFGSNTSTTGSLFGSKPASNPFGSTASNTGGGLFGSSTTNTGGFGSGGGFGGSTTNNAFGGNTGSSGFSFGAAKPAFGSTTNSTPLFGQGGSGTTGGFGSSSSPFGAAGSGTALSNQSVPPSEGTASTPYAPTLEKEAAGVSSNYQSINFMPPYQKYSFEELRLADYNAGRRYGNNTGQAGGFGTNSFGGFGSSNTGGFGGNTNSNPFGAAATTSSGFGANTSTTGFGSGGLFGSKPAGGGLFGQQSSAAPSGGLFGTSNNTSTNAFGGGSSTGFGSGGGLFGNNNNQNQQKPSLFGTNTGNTGSTFSFGNTNTSTTGAGGGLFGTNTNNSTTGAFGGNQQQSGGLFGTNNTQQKPSLFGTSTGSFGAPTNQNQSSGGLFGSNTNTSTGGGLFGNNANTNTGTGGGLFGSQPSTNTGGGLFGSTSNNQQKPGGLFGGSTFGNTNASSTGTGLFGGNNNQQSGGLFGSTNNNTGSGFSFGNNANKPATGSLFGTSTNQQQGGFGNSLFAPAQSTQQNQQQSEFKTSSLNDPNPYGQTSIWTGLPVPTPDNSKPLFTPLSATQKMKESQSKPPPSLRLNQSRYMTPPRRSGFGFSYSTYGTPNSAASTPGGSGLSGSMYGSRSFNGGSFGRSFGKSASVSNLRSHFNAEGSGVLSPDAFAATNTRWSGGSMRRLTIDRSIRNDLFSRPSLPAFPTNGLDKSTNGNTALAPTNLDSSGAEPVNKLKKRVSFDKDTAGGQNGASNGEAGALVTVDDDEDEHERSRITNGSATPEAEPVRGNELAVVPEDRESNDVSSRKVTVQAKPDPQPGDYWMKPTRAELSKLPRDKLSRFVGFEVGRKGCGKVVFNGPVDLTSIPLDDLYEKIVEIRLRSVTVYPDASSKPPVGKGLNVPSTISIENSWPRARGQPSSATSGPIFDKHVNRLKKMNGTEFVSYDVGTGVWTFRVPHYTRYGLDYDEDDELGQSQLSAPPDSLTSSRSADDSGMDVDSEEHDDYEDEGDDDDDTFAFKQKTLPGGYGRQSAIEYEDNVPSAQEVEDGPADSGMEEDDYEEEDQDEMSMAGSYPPPAASPAKPILRASTMGTPGKALINIDGDWAEQLQRTISPRKQNRDALREVQSKVLLDRAYEPMKPSSTKIANKKDFRTSIDIMHSLFSRHEERMADLKGRKGKAQSEPDFEFPYAKRAKTFDDQAQADAIELGEDDRRWHASFKPHFTATNQLIYKSDGLAGDNGWTTQLLAHSEATGKEIVATSLEAGNLENAAMDANALLTDAQVSVKDNVPSIKHDALPFSQVKAHLAQQLGGTDELDVYELLHVLFDDYEDDFTLGLSRQQQQEYMPRIRKDRLSKYLADLVWRRHGDRIRAASKINAATAAILQLTAKNVHAACDALMQEKDFHLTLLVAQIEQVDAAFQEDIATQISDWRGQAVISEMSEEIRALYEILSGNTSIAQGRQNVAVEDRASTFAISEKFELDWIQAFALCLWYGKHKNGDIGEIVADFQSKLSSNLESATPVGSNGYEDPLWVVLRLFASKSKGSRGNAAAVKVEKPVLPQALSALSQPWDSQKTFRLYNAIAAALSDVSIDPEKADALALTLAFEHSARGNIIGAVYALLHLRDPAKRARQIQDLLDRHAASLPAPPLSQSQSQPLWTALTTAFHLPSTWVYRSKALYTRSCNESLAELHYLVLATDYAQAHACLLGRVAPRFVIDEDWEGLSNVLATFGEDAEQKVDAAVAASAEQDTTPEWKRGGGVYADFVALMALMGPSLPAARRASSQDAIDKRKNKAALLERLQGALRGLNARFESSSSASAPASAPASAPASASDSNSRTLDLTKDREKLEERVALREMGKAVARVIELEHDSGVADQKSILELPLTADARLVHARALGVEYYRGVMAVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C702</accession>
    <name>A0A1C1C702_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RPD3</name>
        <name evidence="12" type="ORF">CLCR_05541</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C702"/>
    <dbReference type="STRING" id="86049.A0A1C1C702"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05541"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07012"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10004">
        <property type="entry name" value="RPD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="36"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="382"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="654"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT44315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="717" mass="78324" checksum="04849D3D4839722C" modified="2016-11-02" version="1">MAFAPVDAPNHKREDKKRVAYFYDSDVGNYAYVSGHPMKPHRIRLAHSLVMNYGLYKKMEIYRAKPASKYEMTQFHTDEYIDFLAKVTPDNMDSYQKEQQKYNVGDDCPVFDGLFEFCGISAGGSMEGAARLNRQKADIAINWAGGLHHAKKSEASGFCYVNDIVLGIIELLRFHKRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGELRDIGVGLGKHYAVNFPLRDGIDDTSYKGIFEPVIRATMEYYQPSAVVLQCGGDSLSGDRLGCFNLSMKGHANCVQFVKSFNLPTLILGGGGYTMRNVARTWAFETGCLVGEQMTANLPYNDYYEYYAPDYELDVRPSNMDNANSREYLDKILTQVLENMKRTAHAPSVQMTDVPRDSLGMNDDDEAALDDLDEDENTDKRRTQRRADKYVQKDGELSDSEDEEMEIDGNGRPSGSRKRRVMQNYRHIMDVGGNDSGIETGSGMGTPQQASSLPDEAADEMNVDDDLERIGQPTPSPQNGENVNGAAPASDPQSPIHDAPAVDDGDVEMGDADAPNGHILAATAAQHELPHPMEEATSTVQQQRTPPDSPPTPGEEAPSPAAANATVAETTTHAAEDESVIAVPPPHIPPATTEPEATGATAEEAAIKQEVIGDDEAAKAREEGRMERELANAEGEAKTEAVAKVEAAEGDAEATIVERPAQGDGEPEAGSGPEAKQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7H6</accession>
    <name>A0A1C1C7H6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_05353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7H6"/>
    <dbReference type="STRING" id="86049.A0A1C1C7H6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05353"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07166"/>
    <dbReference type="eggNOG" id="ENOG502QU12">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3598281at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056024">
        <property type="entry name" value="DUF7605"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24564">
        <property type="entry name" value="DUF7605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="3">
        <location>
            <begin position="472"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7605" evidence="4">
        <location>
            <begin position="1114"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="810"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1378"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="762"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="893"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1215"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="843"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="855"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="872"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1392"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1425"/>
            <end position="1435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1447" mass="162541" checksum="236096D8DDA80F7E" modified="2016-11-02" version="1">MVTPSEFFETLRALRPQDELKPGVVFVAILHYDKLPDGPFDQPDALWIKCPREKDVSSLVNAYRRECPEAGDFVLRHNFQVLEEETKISALANRYPNDFVALEAVTVKDLNKRKYLTAARAPLTEIANGVNRSLVKAQTSSKFNNEAHTKESQPRPLEQPQVWSVRRPSKPEPACPPPSLRASPHALSMPDTLAPTEQTAWEDFLFERLEISRISSTLDSTSLPDTDEPSATDEAIKEEWLGLDQGQKSYFIERAGKIVSTLGFTSPEDRYAEHWGFWSFYCSECYATEPAIGGHRDRDFETRNRQIEDSLALWTTMKPNARKKWVADLRSHVSAAVKRGAISQPQCSSSPVQPNQASTPTTGIKSEQKSSPSPRHDENNIPQFDGPATGIDFQVELEDVPGPSTAASTRLSMAELFDGRTPEQLEKSVQEGVVLLGSIKRALQEQPSQDATQWLQTIENVQKQATRSKTVIGVVGATGAGKSSVINAMLDEERLVPTNCMRACTAVVTEISYNHEEGAPYRAEVEFISRDDWHKMLKILFQDLLDNSGQVSRECTDEDSESGIAYAQIKAVYPRMTKDDMENITIDRLIEHDNVACLGTTREIQSDDPTMFYKKLQRYVDSKEKTHGMKEKARKKDSKPREMEFWPLIRVVRLYVKAPALATGAVIVDLPGVHDSNQARAAVAQGYMKQCTGLWIVAPITRAVDDKSAKTLLGDTFKRQLKMDGGFDSVTFICSKTDDISITEAQDSLGLDEELTPMWEKWEELRKRKNHLQRQINDLKDTKLDITAAMETAEEDLELWEALQQDFNDGKTVFRPTSKSQKRKREDDTGPTKKKKRPNYQEPDSDDDFIDDGDSSSSDAGSDNGSSGTGEDASEPLQEDEIAMKIADLRGTRKEGRREKIRIDQELQKLEDQIKDIEKESEHIDGTLSAKCISGRNEYSRAAIRQDYAAGIRELDQEIAEEEDAANFDPEIDRRNYDEVARNLPVFCVSSRAYQKLRGRLQKDKSPPGFTHIDETEMPALQAHCIQLTTASRMTLLNSLRLWASNEGTGRSLTEGQVKREAQILKERLDKLDSALEKAVTAIVDGIEEELQDKVYDAYPTATGAAQSEANNTVQKWGSPVNRENLMAGGLYWSTYKAVVRRDGVFNNARASNNFNEQLTEPVIRHLAGPWESVFARRLPGILNSLPANAGQILTSFHDEVERRAIRNGASIASFQMLKHQIAVYKETLKDAINEARNLMSERQRNINREFEPRVREHMLPVYYTCTAETGPGQFARMKGYIDRHVEQEKLTMFNDAVEHVRELLDQMLKEMKSILLGKVDAVLTAIERDYTGVVVGQDQGQRHEMLPRDQRMMRRAVIEIIDSAELVFKRAVGLVPDPAEPDTQVQADAEVESKHEPIDAVKDEPEERGSLDLVPYALAVPQGDLSTASKSSTDTEVEAAATEIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8K2</accession>
    <name>A0A1C1C8K2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ADH6</name>
        <name evidence="14" type="ORF">CLCR_05997</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8K2"/>
    <dbReference type="STRING" id="86049.A0A1C1C8K2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05997"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07463"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="13">
        <location>
            <begin position="32"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="194"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT44789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="366" mass="39752" checksum="FC9FCEFC1104966C" modified="2016-11-02" version="1">MGYPDTFEGFMIKDQKNWTDFHKQEFKPKKFGEHDVDIQIECCGVCGSDVHTINGGWGEAPLPICVGHEVVGKAVKVGDAVTTCKVGDRVGVGAQIWACLKCPQCKSDNENYCPHMVDTYGAPYPKEVDPDETISQGGYASHIRAHEYFVFPIPDAIPSHLAAPMLCAGLTTWSPLVRAGVGPGKKVAVVGLGGLGHFAVIWANALGAEVTVISHSPHKKDDALKLGAKEFVTNNEKGWADKYQFAFDFVLNTADMTHTFDLGEYLSLCKVNATFHQVGLPDEALPPLKAQMFMSNGSSIGASHIGNRPEALAMLKLAAEKQLFPMVETVSISEKGCAEAVSRVANNKIKYRFTLTDYDKVFGARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8P4</accession>
    <name>A0A1C1C8P4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AB hydrolase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8P4"/>
    <dbReference type="STRING" id="86049.A0A1C1C8P4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05984"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07548"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="118"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="357" mass="39364" checksum="F10C0D3391FFEA66" modified="2016-11-02" version="1">MTTTRARQSNPEKVDMVAQLAPVQSPPNPLHPSVQDRLHPEYVAFYNKYILHAQQVHLLPVEVARISGNVPPSHSKPLPVGKIHDLSLSRRETAGPEVPIRCFIPPGAPPRSGWPLVHYYHGGGWVFGDIDTENTVCTHICVRSRAVVITTDYRLAPEDPFPAAIHDAWESFLWSTSSQGQSRLKLDLSRVAISGASAGANIAAVIAQKAMLRPQPGVSLRSQVLVVPVTDNTATPCSSPTWKAFEFTAHLPAKKMLWYRHHYLPNQADWSDREASPLLAPDDVFKLLPRSYIIVGELDVLRHDGEEYARKLTANGVPTELSIAEGMPHPFLAMDAVLEAGRTAITNICEELIRAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C908</accession>
    <name>A0A1C1C908_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C908"/>
    <dbReference type="STRING" id="86049.A0A1C1C908"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05443"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07663"/>
    <dbReference type="eggNOG" id="ENOG502S8TM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="268"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="875" mass="97771" checksum="149DDF7E22B5FA9C" modified="2016-11-02" version="1">MAQLCEACTIFATCNLPAKQVWCNAKFPHYASGTELHQSAERGCHLCQFIEAALLRYNRTPGETSLPDRQIWLQCVQQSHNHNTNAIQISIEPLGLRSAGYRGLDTHDVDHCLWLPAEDDPEQKLAMLEAMSNGPLGKLGPVAGVVVHNTGRIYFYRGRTLTADVFYAIRQPFYRAEIPCVLIPDHVSQALDTGLGLSVQGVQDDSTGSFANLFLVIAWLNRCLTHHSTCRGYAEVAGQLPSRVLDVGQVRSEAVHLHISKPGEKDRYIALSHRWGRTNPLTTTTKTLPDRVAGIALTSLSQTFREAIYVARMLDIKYLWIDSLCILQDSLDDWKEQAALMGTIYRQAFVTIAATDTEDASSGLFFPRSPTKGKPCKLHLPLRKDMFAGESGPLYATSPHFRRGKDIGRVRGPLDTRAWVLQEQILSGRVLNFTKDQVYFECLSTEASEVLPYTLENAMDDESHYVSTLKHGIGGLLPHDKPEASMYLHRAWYLMVEDYSRRQLTVPTDKWVAMLGIVTEMQRATDDVCSFGLWNRWLAHDLLWAVYSASYPRTSLRQEKMITPGPTGKRNTSLSVPSWSWLQIEGHIKYLPDPFNIVLQDQVLVQKMELQNADATAPPSVDHKNLPRLRIRGPLKPGIPALFVADADEDNSEGSGQVAGPPDTSSQEAPTSQHEYPRMAEPDFLSAALDPTDDRATRTWRIASDLEEEIYGPKPMMDEDEPIIGVIPQGRLSHVIHDHVLADRPNADRRMTELYARGSGSDELRQTFLKEEANKYVVATTIKKTPIGFWAPDIDGELPTARLDELGTLLDEEITSLLFVGICRGRGWVRCLGLQLVGTGVEAMLANVWRRVGMAWILEEAWDQTGGIETAVTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C964</accession>
    <name>A0A1C1C964_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear transport factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NTF2</name>
        <name evidence="6" type="ORF">CLCR_06160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates protein transport into the nucleus. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C964"/>
    <dbReference type="STRING" id="86049.A0A1C1C964"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06160"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07671"/>
    <dbReference type="eggNOG" id="KOG2104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT44999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="166" mass="19029" checksum="DA8094D5EB04987D" modified="2016-11-02" version="1">MGDFATIAQQFVEFYYKTFDSDRTQLAALYMGTQRDKSMLTFEKEQFMGTQSILEKLTNLPFQKVQHRIDTTDAQPFNEQGGILVLVTGALMVDDQQHPMSYVQTFSLVPEGGSYFVFNDVFRCMCSIGIRSEWTWLTCVDSGLCCELRVSQLRSTWRLKINLAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9E5</accession>
    <name>A0A1C1C9E5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin target of PRMT1 protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9E5"/>
    <dbReference type="STRING" id="86049.A0A1C1C9E5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06423"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07760"/>
    <dbReference type="eggNOG" id="KOG0533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Chromatin target of PRMT1 protein C-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="122" mass="12848" checksum="76C16E1EF5CA4281" modified="2016-11-02" version="1">MFQHRLQPSHLRNVLRPLTKTSANPKAQPKSATATKKVVGKDSAKGRPAGKAGKPKRGRNSRPKAKTAEELDAEMTDYWGGNNPSAAGTNTDATATNGAAPAATTGEDAMEEISVSDIEFIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9H8</accession>
    <name>A0A1C1C9H8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylinositol transfer protein PDR16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PDR16</name>
        <name evidence="2" type="ORF">CLCR_05971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9H8"/>
    <dbReference type="STRING" id="86049.A0A1C1C9H8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05971"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07833"/>
    <dbReference type="eggNOG" id="KOG1470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000013">
        <property type="entry name" value="Phosphatidylinositol transfer protein PDR16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="191"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="402" mass="45092" checksum="658E211E51404538" modified="2016-11-02" version="1">MSVDVANNATLPNGSADPEKAAADLATRVGQVKIEDDTTQAVDIPVHDVKGANEIAVAANGIQAEEQPETPSSALKLNLPRTAADGLIKTPLAEPLETSKPAVRPALTAEQETKYAALYKNVSAWTEIPETSAKGSKSTAMTDSERMFLTRECLLRYLRATSWNVAQAETRLRNTLVWRREYGLEKHTKDYISIENATGKQLILGWDNEGRTCQYMRPSKQNTERSDRQIQHLVFMLERSIDMMPCGQETLALLINFAETKSGQGATLSQGKQTLNILQNHYPERLGRALVTNVPFYIWGFFKLITPFIDPLTREKIKFNEDSGIHVPREQLLKESGGLVEFEYDHEIYWPALNDLCELKRQQYRARWEKGGKRIGEYEGYLKGGDEKSLAEREVEAGQSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9J4</accession>
    <name>A0A1C1C9J4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9J4"/>
    <dbReference type="STRING" id="86049.A0A1C1C9J4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06027"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07825"/>
    <dbReference type="eggNOG" id="ENOG502SYFI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5378435at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="367" mass="40338" checksum="48A27D033B7BFA2F" modified="2016-11-02" version="1">MAASQQWSYPLADMTSNTGVSANDSSYFARPSKIVKPNSRNSSPRKLGRRKTTTAASSSSRTRSVVDHLRSNSQWQNSTATRSRPVSWHPDYFEASNFNPSPTVNGGESSCWGFSTAQVNGLITPVAYTPMNEPQIQELFTPLDDLPGMDPSLSYDGREYCQQAWAGQSEPDAYSLPLYAHVSSTQPSWQVNPMAMDPNVQTAPSSPHCLPVQNIGLDTLSLGNMDTKSKDSSEELVAMGLYDSPAEVQSSSLLFGGVPGSVGKSLKLAESFEPTEQECDDEEEEADQTDDDDDDDQKDIKQEEADEKRHIPAAADYDSQSIASHLTYGMQPRPEPLATQYLATLRQMNSAYYPSEYTSHEPGYGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9M5</accession>
    <name>A0A1C1C9M5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="12">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RIP1</name>
        <name evidence="15" type="ORF">CLCR_06351</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="12">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="12"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9M5"/>
    <dbReference type="STRING" id="86049.A0A1C1C9M5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06351"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07886"/>
    <dbReference type="eggNOG" id="KOG1671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="14">
        <location>
            <begin position="65"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT45233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="135" mass="14937" checksum="117F4A4AB2EFE4DE" modified="2016-11-02" version="1">MSASADVLAQAKVEIDLAAIPEGKNVIIKWRGKPVFIRHRTEDEIKEAESIDLSVLRDPEKDSDRVKKPEWLVMLGVCTHLGCVPIGEAGDFGGWFCPCHGSHYDISGRVRKGPAPLNLEVPEYDFPEDDKLVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA94</accession>
    <name>A0A1C1CA94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative AIM2 family protein C30D10.14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA94"/>
    <dbReference type="STRING" id="86049.A0A1C1CA94"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06215"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08081"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="252" mass="27836" checksum="57831D1C038ECD44" modified="2016-11-02" version="1">MSQTQTPSAGCCNTPAVVSKGYKEKGEWTTVDGLKTYVTGPSTATQGILVVYDIFGYFPQTLQGADILAHADKEHQYQVFMPDFFEGKPADISWYPPDTEEKGKKLGEFFQTTAAPPKTVEKVKSVMKELTAKNSGIQFWGIVGYCWGGKIVNLSAGAGTPFKAAAACHPAMVDPNDAPNVTIPMLMIPSKDEDQEAVDKYEKGLKVAHQIEWFKDQVHGFMAARGDLEKEDVKAAYEKAYQHLLDFFHKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAB5</accession>
    <name>A0A1C1CAB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SNF7 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAB5"/>
    <dbReference type="STRING" id="86049.A0A1C1CAB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05776"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08025"/>
    <dbReference type="eggNOG" id="KOG2911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250120at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="58091" checksum="2648BFEA6A63678B" modified="2016-11-02" version="1">MPSPLLDYLVAHEPLFRPTRLPSLYSDLAVQKKSNPEGYAANATAWTAALTRLALAGRLPPDRNTLVLRTGDALLDALTSPTYGPPNHLGCVLDDAVAQGVFIDGPEFLGAVRSIYARSWVPSPRAVLRWGLRTVGLEFGSGSYTVGGSGSSSSSGKLRPGTLVVVPALEEVSNRLQPLITGMGSALTDRVMSPEAFAQEVGVLLAKSRGQGEDEGTSISDTDLQVLLRYLSRDKQLLSYDAEVVKFKAPASSSTGPEPITQEDRSIASLKSLMESLRRQTTTLSARVVGLQTQAAQAVKMGNKASALSALRSKKLADRALQSRLDNLAQLEEIYTKVESAVSQVEILAVMESSATALKTLSAKVGGVERVEDVLDSLRDEVSKVDEVSNVLSEPGAVDQKALLDEADVDDELEQMEREEREKSQKAQEEKTREKLQQLEALERVRWEQEREREQQRKQQEQEQEQEKVNDDLSSSIEKMRTLGIDDLRTRDDAPGRAKEREQEQEQEREQEQEQEESHRNAIAQEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAD1</accession>
    <name>A0A1C1CAD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_01633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAD1"/>
    <dbReference type="STRING" id="86049.A0A1C1CAD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01633"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03414"/>
    <dbReference type="eggNOG" id="ENOG502RYDJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="53"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT45503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="328" mass="36903" checksum="7D5F9CF46368F97D" modified="2016-11-02" version="1">MASVYPQQTPPSPPESPSEATVEVYALSGGHFSLPERFFVHPASQTARRTVPSLSFLVVHRDQETDRKTRIVFDLGLRRDIKRYSPPIQKHVETRQPMVTLPDVTASLAAGGLTPDDIEYVIYSHLKVHWDHVGEPRDFPRSTFVIGNGAKALLHGGGSLRGSHSFFESDLLPTDRTIELSNPYEDIDEETKHQILDPNAPDFIQEWKASGNLPRVLDIFHDGSLLIVDSPGHLPGHINLLARTSPSTSVYLAGDACHDRRIMRNERQIGEWLDEHGHICCIHADKKLAEQTIERIQALEKSGVEVIFAHDFEWEEDPKNRSRFFGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB51</accession>
    <name>A0A1C1CB51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB51"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01535"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03580"/>
    <dbReference type="eggNOG" id="ENOG502SYIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="33972" checksum="AEB6D07E316AB2DA" modified="2016-11-02" version="1">MPTRISGACNGCRTKKQKCSGDRGPAKGYIEGLEHRLHEAESLLLALLPIISTEQLKCATDSLADGPSTINIPGLKTRDSQSPGPHALRTSPPVLNKKTGIDYWESFPLDTVENIRKWQNDCAAHSGAANGQTQSLRNSIDDSQSHTNILAALNHGPSHSRPASVDLSRHGHGHNHSHSQSAPFRSMSSDSYRSGASTPIHMPQHSHSQPSLPTTSGSQQQSSQQQTSTPNWQSLTLFSPNTTTSSPNVTSSPSAGTGAGIGAEALLLQSFADSSWAQAQTMNSGMGMSGMGNGLSVESGPMEVDTGFFSSDMQRRLFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBN4</accession>
    <name>A0A1C1CBN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBN4"/>
    <dbReference type="STRING" id="86049.A0A1C1CBN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00496"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10079"/>
    <dbReference type="OrthoDB" id="5383784at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="221" mass="25209" checksum="692CCE1E7F050E33" modified="2016-11-02" version="1">MGRQSHLARLALGRSPFDAPLQDENGDLILGPNVQHDTGRNYTQDFDSRGHPRNLRSEMSRRRLLRAQNEALYTVGVVVKKAKANRSRWQTMDDKQKFRLVVEENTAGAYLGLSESILQRLSTLWIQNIRRRVLTYKSYLELPVSHMISSDWHTVGAGAFLFAGILPATFARISQYVRLALLREDAGSSLPDRIFSRLRRSGVASTFRYARQDIPKLPLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBU0</accession>
    <name>A0A1C1CBU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PBDC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YPL225W</name>
        <name evidence="6" type="ORF">CLCR_00528</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PBDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBU0"/>
    <dbReference type="STRING" id="86049.A0A1C1CBU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00528"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10067"/>
    <dbReference type="eggNOG" id="KOG4093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248897at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990593">
        <property type="term" value="F:nascent polypeptide-associated complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061770">
        <property type="term" value="F:translation elongation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3560.10:FF:000001">
        <property type="entry name" value="Protein PBDC1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="5">
        <location>
            <begin position="18"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT45938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="156" mass="18619" checksum="A2011B8EB31A4DC8" modified="2016-11-02" version="1">MSLTQQIDPDNVPNYEDMEKQFAVKAVQHMTVYWSILEKLPGSRLRLTRLDDQIFEHFKREFPDFDPAQELDEDAMKSKQGKEKWRKFSMAYEKGDNKIEDYNFGTMLRKSPKTEYGEKETIFAVRMQFYAIEIARNRAGLNDWIYENAQKEQKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBX4</accession>
    <name>A0A1C1CBX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">eaf1</name>
        <name evidence="12" type="ORF">CLCR_00354</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT45978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBX4"/>
    <dbReference type="STRING" id="86049.A0A1C1CBX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00354"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10033"/>
    <dbReference type="eggNOG" id="ENOG502RGMX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5364245at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="11">
        <location>
            <begin position="560"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="818"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="55"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="751"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1015"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1121"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1169"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1227"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1345"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="751"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1016"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1125"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1169"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1227"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1348"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1388"/>
            <end position="1397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT45978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1397" mass="152492" checksum="0E045FE431438646" modified="2016-11-02" version="1">MPVEHLRSKKSEAQRLVQSRKRKLNELFSISIPAHDPTYKQKLQAFHDANDLEKGCRFDENTLPPLSHIVLRSRKSAPKQPHTAASPPSATIQQPKSASKTTAPSSPTPKPTPKPIAARQTPPTPKPLEGNERDEVATSVTGEDHGLGNQATASAGLNTQNGEFVASPDRGDRRSKSPRVPAVEATVIDQSDGTLLKSPGARTGTASSAVAETRPFPPVDHRSSRTPPPLAPIAPPADPQSSPASSNGPDSSNTPAPDAGSPGTSPGVDVASATSLVPQATKAKDTGQPDSGLSPAHQDRDYQRGAGRTGTPSVDVEMTGANDVGSISSNWADQSKLSAEPSKIPSPQRPVMQIDTRTESDSYFKARPSGGLVESPAQLTGITPRRNVPATPSVEEPPKRATRISSGVLQKKSVSEILGETPRTTTPQADSPRDSFGATTPQGRTAERDRRDKDRSRLSTVVFAKREKAVGGDEDNLEMVPYEGEAQRKSPADRDYLYTLFENKAHSMSRQTSMSYLIQNAHKALSTSDHLIEYELSAECRILKRLYQLQEKQRWALRQYKRAEEAPRPTSHWDFLLDHVKWMRTDFKEERKWKMAAARGLAECCADWVASSAEQRRRLQVRVRPPKLLSKPAISDDVAMEDEPVASLSSQPTPELVPSNEDDSMSDDIAELRDVQISRAPAALFSLGPSDFNFAVDQTPALDKLLNELPLYGPYGDPDTSKSALAERLDAKWRTDIVPVSRWATEKLPVKDHKPPVKQSRYDYDLEPSPKKKSDPLPPEETNVALFMPENKIIRDRIHPGHSFRPPSEHPMPTQAFFETRSSSQWTAAEDDELKRLVKDYSYNWSLISSCLTPPSLYTSGADRRTPWECFERWIGLEGLPADMSKTAYFKTYSGRIEAAGRHVAAQIEEAQRRAGANVQISARRRTTQPVKVERKRTQRHLAMLDAMRKLAKKRETALQKQQHQADLAAMRKVNDANVPKPSYKTPAEFSQLKQEREQKLAERQEIYRQQLIAHQRATAQQQRTQNGQPNGLPNGIPAAAPGMRAPSMGSMPGMPNGNIQMPNGHRPHPAMIAAMQGNMQLPPGMMAPKLTPQMQAQMQAQLAARGGMTSPQQMRMLQEATRVQQEQLMRQAQQAQNGPHSSPNNPHVALANGQGLNNAAYRAAMAATANGNGSPSGPLNGSSPRPNTANSGQALSSGHVPVLTQIANKIREHHPNLSDEEVQRLASQQLQTYQHQATQAAAGHTSQKRPQHNQAALNAALGAMNAGNNASAATATAAAAAQLGHPGMMTNEQVQQYNQRIRMQQAQQRAQRNLQAMQMQQQMGGGMANVNGMAGSPVMNMARPVSQHANPQGQMSRSATPRDQRSGSQSGINGNGTGNGQGQQSSPRQPAQSMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDX2</accession>
    <name>A0A1C1CDX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_01980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDX2"/>
    <dbReference type="STRING" id="86049.A0A1C1CDX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01980"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01450"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="15"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="343" mass="36998" checksum="AC2CB2B3F5E4150D" modified="2016-11-02" version="1">MQKSTSLGGKLTYKYSFLDQRFALAWVQRNIAAFGGDPAKVTIFGESAGGLSVDALVTSFAIKPPFRAAIEESGQGTYRALAADPHRSWNTLAAAVGCNTTASALKCMRGLPASTLKNASEHLGLAFTAMVDNYTFVANRSEARASGKIAKVPVLAGTNADEGTVFTYGDTNLTEYLTAALPTAPESYLGQIVNAYPIGSPGITNVSQQIAKIYTEFSFQCTQARQLRDTRRAGIPTWRYFYNATIPQLELFPGAGVYHSAEIQLVFGTYRNNAQQTPFERKLSAYIMGAWARFAKNPTQGPGWPQLPVVADLGGNGVTNTSIQSSAIDARCALFDPVYDLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEB3</accession>
    <name>A0A1C1CEB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEB3"/>
    <dbReference type="STRING" id="86049.A0A1C1CEB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02140"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01584"/>
    <dbReference type="eggNOG" id="ENOG502SUV6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="285219at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14361">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052617">
        <property type="entry name" value="Huntingtin-int_K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038922">
        <property type="entry name" value="HYPK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="2">
        <location>
            <begin position="100"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="146" mass="15271" checksum="F9F79A429CEF8DC0" modified="2016-11-02" version="1">MAEPVPSASAAAADAADDEASQNLPKNAEDRKAAVALNSLNANEMSTDNGETGPKQPSAADQEALGKAMSRLEIASGVSKKKEDPTKAETKKEIEVKKKIKIAAEDVNFLVEELDLSKNKATELLRSHDGNASLAIKAFITPAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CED3</accession>
    <name>A0A1C1CED3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proteasome component ECM29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_01781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CED3"/>
    <dbReference type="STRING" id="86049.A0A1C1CED3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01781"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01520"/>
    <dbReference type="eggNOG" id="KOG0915">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16066at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055443">
        <property type="entry name" value="HEAT_ECM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23731">
        <property type="entry name" value="ARM_ECM29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24492">
        <property type="entry name" value="HEAT_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="6">
        <location>
            <begin position="17"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome adapter and scaffold protein ECM29 HEAT-repeat" evidence="7">
        <location>
            <begin position="1255"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1326"/>
            <end position="1345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT46807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1669" mass="185783" checksum="25305D36ABD33756" modified="2016-11-02" version="1">MATKQLPPDSEREYGLISKLELRIASASTDEKLGEILHKFLPALLLKLASPTERNRNLTIKVCQYISQRLKINTSIKLPVGALVKTFRENENAFVRRFCLIFIEQGLPRLETGQAIETLPGVLQFAIPKIASYDATDRKMWAIAFDFLLEVLRKWKIPQRGSKEDLALTESFCLSTTQTDLLVSRLCDFLLYDPKDTTTTTQPLDGDFQPIMEKNHKRRSEIVLPIATFLFTALFRDAQRLVPAVIMSVDANASASNTSDVMFKQCTFDLESEDTVDALFALYQRSKPKLRTKILALLSKSQASTSRTGEIMKMVQAQLMNVGNGGLEASKLRAALFSYLSWTVRVGGHHLAGDINIRIQDLLKEYIEMQGWPIMGSEQSSPAEIELRSKAYESIGSLAALKTESTSDARTLDLITWLFTSLRCDTTRDIRSSIEESIGRIMNALPVSFREDPSLTNRLRDLLLWNVLARPGQEDPIYFHPTVNSTTYPAVRFVNRCFPFHDVGARFIDVLALASTEGRREIAEEAARGLDPYWHASNVRLSSSPDGRKLELPELDVLAKRFFGGKGNETDHYNDPVVLATAVGFCRNILVCEALRETKLAPEDFADWKQSIDALVNNDKDARHRIRLYLQNVNAHDVLLPLIHAAMHGVSKSSADCLDLSLEILSIAPNELLAEVDVVGLDAVQRVSANAGLQLRAARIFGILASLKNDAEALAKAEFDQVGRWKTAVGEEAVKIQGHLLRVCFCFTRKALRVPDQISKDLGSDFLQTVLDIINMSSDRGLKDTAYRCLRQLALCTSGVFASEDEGLADQLISDGKKESETAISAAGPMLGILHAKNSDSALFKSFLDRLLGLYEVKRAEFHFALGEALAVACAGFRSSSTVTEFDVDVDVSKFKVNDALLASILDRVIEDCKTTKPSLKKAAAIWLLCLIQYCGELPVVRARLRDCQSAFARLLNDRDEIVQETGSRGLSLVYEQGDKQLRDDLVRDLVQSFTGSKAKMSGTVSEDTQLFEAGALPTENGQSVTTYKDIVSLATEMGDPSLVYRFMNLASNNAIWNSRAAFGRFGLGSVLADSTYLTENKKFYPKLYRYRFDPNPNVQRSMNEIWRALVKDPTAVINENFDLIMDDLLQSVVSGKDWRAREASCAAISDLVQGREVEKFEKYLDDVWKVAFKVMDDVKETVRTAAMKLCRTLTSMLIRNLEVGEGSTKRSATMLNHAMPFLLQQMDSGGAKEVQQYAIVTLLEVIKKAPPKSLGPYAPTILETLVLSLSSLEHEGINYLHLNADKYGLTAEKLDKMRVSSINASPVTEAIEDCLESITMKVEPDADPNAMQGVEPTSGSKGSVTPMEDAMQRLAGAYRAAIGLPSKVGLSRVMTTLVVRHPTAFRPYADKFAQLTRKHLLDRNATISVAFSTSLGYLMRLTSEKEIQATSKYAQKLYFESQELSHRAVAGEIIQAISKAANDVFMNSAAVFLPFAFIGRRDTDEEVRDRFDVPWKENIGGSRSINLYLSEIVGLISTHTGSPLWPVRHACCFAVAELISSMEVQEKYSDTEAALIWPLIQSALDGKTWDGKEEIIKVYPKFVQQARSLWADSKTSQQMRKIAIREAKRTNVMYRPDAIGALGDFAVARKDLDLTMEMMPHLDELMVELMDQDAMEVDEASGGSRKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEW3</accession>
    <name>A0A1C1CEW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">nop58</name>
        <name evidence="11" type="ORF">CLCR_02322</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEW3"/>
    <dbReference type="STRING" id="86049.A0A1C1CEW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02322"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02407"/>
    <dbReference type="eggNOG" id="KOG2572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902570">
        <property type="term" value="P:protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="285"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="415"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="601"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT47011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="667" mass="72791" checksum="60EDEB9AA5767886" modified="2016-11-02" version="1">MTLLILTETSAGYALLKAKDKKLLKRDDLASELTSVESVTSQLKLKEFQKFDSAAAALEEAAAIVEGKVTPKLSSLLNSLKDEKKISLAVADPKLGNAIGKIPGLDIKAVADSATADLYRSIREHLPSLIPGLLPDDMKTMSLGLSHSLARHKLKFSPDKIDVMIVQAIGLLDDLDKELNTYAMRVKEWYGWHFPEMAKILNDNLAYAKVVLKMGMRTNWETCDLAEILPEEIEAAVKAAADRSMGTEITDEDLENIQSLAEQVVQFTEYRTQLASYLSARMTAIAPNLTALVGELVGARLIAHAGSLMNLSKSPASTIQILGAEKALFRALKTKHDTPKYGLIYHASLIGQASGKNKGKMARVLAAKAALGLRVDALQEWGDDEANIPEDEKAALGLSSRAYLERKLAGMEGKPLKPRGVAIAPNGVSATPQPKKWEIKEARKYNPDADGLSGDEAPAKEEKKSKKAKKSKEEPKKLIEEIAEPEELGSGVRQEEDEDEDEDMEDESEPDEPTTQAEVDAIVPSSVNGVNGSSSTRSTREARKSEKERKAAEKAARKAAKKEKKAQAGNAATADQSETDIAKFAKQCGLSVERYKRKLVRGEIHFDEDGKASAISKKDIKKLKRAAEKANSAKTNGEVEGTKKRKRTDEDAETPKADKKKKRKEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG03</accession>
    <name>A0A1C1CG03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_03259</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG03"/>
    <dbReference type="STRING" id="86049.A0A1C1CG03"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03259"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01988"/>
    <dbReference type="eggNOG" id="KOG2169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27975at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Chromo" evidence="7">
        <location>
            <begin position="732"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="8">
        <location>
            <begin position="1205"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="563"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="705"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="794"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="864"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1317"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="678"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="864"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="895"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1317"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1349"/>
            <end position="1358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1369" mass="150096" checksum="B676710B34DE59BE" modified="2016-11-02" version="1">MPDHSADFPLSAAAVQSSNATSNLFLGTAPRSWMVNGSAAANRVTVQPQPARRCSNPARKRPKLQRLKTTLPAESPDEHSTIMVASPSYDLPTFTRESRPAQSTAEDKNVRQQDTLHSLTISSTADAHHQQPVPASNTVTLDWPTVSNAEIEDMSRVPGLEERSAVAVRPSPVNPNTTTAVDGEGNVQAEVVTLVGDDAEHLVTLPSPEVNLLPDLPPTNASHEEIDLFRPSSTQGASPSDRAALLDTSTGSHFAPVGATPPADGGHPESRRKRVADMRLSEDRRTRGRLSADVDDLQLQLPTPQDSPITSKMATLSEKFESVLGEIVAGPITINPQLVIDSRRVEMIHDACRLNDRFFLLAHHLYCLWSDTQQDILDQLHLTEMHFKGMQVLEQVFGAKRYLTAGVFQVFLTFPQPAEALLQDGSYEFAVLLEEVRCFLFHLGTGFFTLRDSALNRKCPPCPAEFKFSLKLPSPVLQKALFRSILRQTHNDQAWLPQALSLFSNEMDNPAGSAISIAELNAYHGAQLAPIVSRWTHVYAQRLKEYEAARNAGVTLPPASAQLSMDIDQGPSSAQMYISPGPVAGSPDAPAHIQGLPQPPHSVPVAPPQSVSRASDSTFRPGHFFPASSSPMRFSTQSPQSPNPPQHSYPTSLRSQPVASPWTQSHGNISPNFPAPPQTTHSNPHPQFRSQDWNGITRGQALPNYANQINPGTPRIAPMEPMRLPPSSRPVWRGLTILEERQRDGRTEFRVRWKGTNIPDGSWVPETQLQNAQREIAAFRARVAAFETRRLQQRDLGIPRPGEPTRQTQQHIASPNPMNPALLQQHRAHGPQLLSNLAGQQPATPQEAGPAVRYQQYSPMLQSPQATNIQQRPAVRTPTSSRGCLGTPGMHVPPSAQQLSSPSTSTNVIAPARPDSMRTPASIQSQQIAGPETLFNGSSQMPLPTLPAARPPQSAIPQYGQPQQHAAPQQGLPFFHPDPNFVLAQMAVPNPDHFALHQAGLRSPEYRKMIDLDGNDSDARYYQYVEDIIELPELITRDSGLLRWNMHIPQQVWSRRTTPLPAFGEFLIPQRKVANGNVQFRLKAIAIAVKEGRSRPTSSEFCTQPTKWPKCLSVSINEHQGVDFRRKAHYGADLATDITEMVKEGDNEIVVGATFSPQEAQVKFLMAVEIICIADHQRLLKMPTRMPAADALAAITNSWTNMAEDDDELVIRRAMSIDLLDPFTSVICVTPVRGSECRHLQCFDLEAFLSSRPGRTKDSGLSSPDKWLCPICKSDCRPPMLVIDEFLMGVRNTLEENGQLLAKVKAILVRDGGTWEPRLEEASNDEGRGMPASNPSNTGTPAPPPPAATGPIAAHAAPAIIVLDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG93</accession>
    <name>A0A1C1CG93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylinositol glycan, class Q</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG93"/>
    <dbReference type="STRING" id="86049.A0A1C1CG93"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11283"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01908"/>
    <dbReference type="eggNOG" id="ENOG502S5U1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="100" mass="11303" checksum="A6497A51ABE61A3F" modified="2016-11-02" version="1">MRADQGAWMHPFSSLTIFIFVAGYITARWDLVTRLYELAIFAWDHGVFARAAKAFAVISLIYACLAIPLDRLAAHEASVHPRFLVHGISAQEQLRRRGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG97</accession>
    <name>A0A1C1CG97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxy-cis,cis-muconate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG97"/>
    <dbReference type="STRING" id="86049.A0A1C1CG97"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03550"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01880"/>
    <dbReference type="eggNOG" id="ENOG502SIAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1715191at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000244">
        <property type="entry name" value="Carboxy-cis,cis-muconate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="360" mass="40512" checksum="7AC176B05DCEF62F" modified="2016-11-02" version="1">MKHHLMIGTWTPPGAIFTVEFDDEAWTLKLVKKTSIPADEPISWMTFDHARRNIYGASMKKWSSHAVKAPDNISHEVSHPMNHDPRAQSADTRTRAIFVLAAKQPPYCVYGNPFYEHAGYGNVFSVADKGKLDKNIQNYEYSEKSAIHGMVFDPTETCLYSADMWADKIWTHKKASDGTLTLVGSVDAPAAGDHPRWVEIHPSGHYLYVLMEAGNRLGVYVIDETTHLPVFTHDLYPLVPPGVRDLKKMYRSDVVFCSQSGKYLFATARSNSSSVTGYISAFKLGPQGQVQRQLCISPTPNSGGHSNAVSPCPWTDEWLALTDDQDGWVEIYRWHDEYLSRVAHLDIKEPGFGMNAIWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGC3</accession>
    <name>A0A1C1CGC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Benzoate 4-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bphA</name>
        <name evidence="8" type="ORF">CLCR_03370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGC3"/>
    <dbReference type="STRING" id="86049.A0A1C1CGC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03370"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01853"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF103">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT47532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="525" mass="59739" checksum="A5C25CF78EA29C6F" modified="2016-11-02" version="1">MTTSLTMHGKAESVAYQVVDTVRQRPWGLPVAVVFVCIFTFTIYQRWLSPLAKIDGPFWASLTPLWKLLSFNNGNFHETILALHERYGPIVRIAPNEVIIADKSAIREIYNTIQGRDFLKTTYYDAFTAFRPTIFGQRDPHLHAQRKRIVSHGYSMNALQAMEKFVQERVQIFMRKMSEYAASGTEINLGKWCHFFAFDVIGELAFSEGFGMLETGVEDEHIRLINNQMEFGSTIGMMPSLIPYTKLTWLPIPWLQSLQAGRERLKELTKSRVERRQEKVSDRKDLLGRLIEAKDPVTGQMLDSIDLRTEAFSSIVAGSDSTSSALSYTFYHILGHPAVYEALTKELRTTFPERTYLTDETPPTYADFGKLPYLQAVIKESLRLTPPATINLPRYVPEGGRVIAGTYFPAKTIVGMSPMPVHLNSEIFGPDAEMFNPDRWIRGSGGISPEEMQRYWMPFGHGSRQCIGKNVAMMELVKLVGTLLLYFDVKLVTSSGEKLPEIPVSRSFFFARMQDPLMVRIRDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGC6</accession>
    <name>A0A1C1CGC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03688"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01867"/>
    <dbReference type="OrthoDB" id="4142560at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="222" mass="25597" checksum="47E1C3A5E8E43B77" modified="2016-11-02" version="1">MTFWQQRRIPINKGWGPCKRTHWVPVNEHYSVQGLDGMTRTWDWRVGIDPGAFAPTGGFNTPGNMGYGGFLERGPGGPVVVVRDRDRGHGLSNRALNELLDDILARDPDDDRRAASERREDEFRARWLALHNEGNACRERFGGHIETYESRTTQPINDSRLTSLRAEAATYADRGKQRAEEQARRDRERLWELRDADLGREARADLEDYGFVRVAPVRRPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGK2</accession>
    <name>A0A1C1CGK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03685"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10151"/>
    <dbReference type="OrthoDB" id="5386133at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="136" mass="14828" checksum="D1C21334BF5061BD" modified="2016-11-02" version="1">MVSGGSHFRYSDEVRNLVLVQLAAGVKPSDIAAALGVSQPFISQVKTRSAIDPEILELLVQQPQARAGKEKRISQISEAGTIGANATPASCEDRSACEQIQDEIWTDDKKVRGDDVASHNERIMETFQGCQPPQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH44</accession>
    <name>A0A1C1CH44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH44"/>
    <dbReference type="STRING" id="86049.A0A1C1CH44"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03771"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04544"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10368" checksum="5375758E278CFD10" modified="2016-11-02" version="1">MPSKATHIIRFIANEDNRIHLGQLVDTSRDIGLDSLEGKEIKAYLINGSIFAPEVTEHVYTVKQLLSPVSQEDCNYIRCLGLNYKDHAAVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHL7</accession>
    <name>A0A1C1CHL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_03798</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHL7"/>
    <dbReference type="STRING" id="86049.A0A1C1CHL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03798"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08178"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1062"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="594"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="778"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="929"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1381"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="357"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="468"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="643"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="686"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="800"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="888"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="929"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1381"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1427"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1091"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT48013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1497" mass="162698" checksum="2D944B84BF94E9AF" modified="2016-11-02" version="1">MPYRQNAGASAGIKTRPDEADGHGVALDPHPPTKKQPPSSFPAGSIITPTTSAAASNRDSTENVVTTRRRQSSIPSVAKAPMGPRPLDYGGSLGKRAASNSLAPQFNSLRGASAVASHDPYTNELSINDISRFSFASIQAKPQLQDERDGALNLGNFLEPTFNFDDFQDTIVGTEGPSLNHFPLPGRSTTVKSTQQTEAPTVEQKKPATQPAIPIPSRKGSGVTPITRKTSTASNNSRASVKSDSMSTTATSILRGRRQSHFPPNSFNNATPAPKAPRKSVGPGTFVAPDTSDKSTVRRRPSAGGRKASAESSKGLGSKTLAGRADESGAEDTKTSGTGRSRPSLAPKRQNSKDLLTPSRTPDPSRSTSTTAPQTPTRRSGTPGRTTTPGANAEKNRRVSVMPHHASGLGARTISPTDARRMKRMSIVPPAPPLPQSRISQAPPTPQPEPVPQLPQSDLQSPAIPNRKSLTPSSSRTTPDPNRKSYSSGQSLSSNTSYNSVKNTIVNPARLSQAINSSRLPTPKPRLDISTNSNYEMEVPPVPAIPKAYESPGSELDQPFFSARSSSLPPFDGAISASPVVSTIADAMKTLETPRAPSDASHNSNAPPVPTLPLEPEPERQPQTQPLTQPKQQPQHKASKKALQTLRLPPLNLLPLSTPTSAKIRSLNVKSESGGSPATPPGMRNNMKTPSTPMTASKASFFSRGHKPAEEAPTMRSSTSHHALRTDELRPPSEISPSLPAFSFEADKSRTLSPFVSTSVPKSNDEFSNYMQPNFMAQLNRNPSQPRPNGPRAPSFSVTPKAEPVPAVPSPVEKPAENESAFSTSALRRKLSRKWSEPKLPESTSQPEDLSKYDNMPPPKLPASATWTNTQTGPASPHRPSYLRSRRQASTSSTNTGPARQESFDSAASTGRPSFESGRTLMVNANRSESLSASTPNLVNHRSPPQRQQEPPLDRDDMVAEEEMKKLASKRKDFESAARELDGLRARAKPATRMSHNTASRIFDLNIFERGEIVDYPDIFFTGTLNSRKIIGDPASASTNFGYDDERGDYNIVEGDHLAYRYEVVDLLGKGSFGQVVRCVDHKTGILVAVKIIRNKKRFHQQALVEVNILQKLKEWVSRTSNVSGLVALTALQDPHKKHSVVNFDQSFYFRGHLCISTDLLGMNLYEFIKAHDFRGFSLKLIRRFTKQLLQCLMLLQQHKVIHCDLKPENILLAHPVHSEIKVIDFGSSCFENEKVYTYIQSRFYRSPEVILGMSYGMPIDMWSVGCILAELFTGYPIFPGENEQEQLACIMEVFGPPEKHLIEKSSRRKLFFDSMGKPRLTVSSKGKRRRPSSKDLRQVLRCDDEAFLDFITKCLKWDPTRRMTPQDAVKHEFITGVKVSSASRIRSATQSAVNSPVKRVNSVTTSGSARPLPQPPSTLKAPAANRQETSPSKPGARRQSNMSGPFAATSQAKRASHAAMNPSASNPSLTRLTIGQRSMSGRSDLAAAAAAASLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI28</accession>
    <name>A0A1C1CI28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_03952</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI28"/>
    <dbReference type="STRING" id="86049.A0A1C1CI28"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03952"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08308"/>
    <dbReference type="eggNOG" id="KOG2460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="365"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="593"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT48158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="641" mass="70522" checksum="DB3BFF0DF7D29ED0" modified="2016-11-02" version="1">MNITSSLISERDKALLGGDYNAYHAQATRKIQNLRRRLGAATRGRKYSPKAPVTAENVSKNADSERAWASAMAMKSAQSPETTQKPMPGSTKRQIASRLRRAITHADNLVNILQDRNTTGAKVLDDLEARAYLSMLKGGLDFEKGRWQACIQNYSVTQVIYSTLARSAKIDAYKDLLSGIVDPSIRYAAYQLKMPRTKALNEIVIENFPQSETTVRQEIEQIDPQAFSAAAEAAPTKGGPKEIPSTLSWRSRKVKLEDANISQALGLSKEKEEDLALSFKSFRDGSLSAKDFATAYEEVITARQDAADATKTAIDELVAEGVDTGDARMQSLQITRTAVNYAVIEWRIGRNRVLCGASDDGLAFEDEKPKRPLKPRKDGKPRAPKEESTGRKMSRLRERVALYDSILQSLDAVKELPGVMADAPFVDELDAKRAYFRALKCLAVGRSHAISDHIPNALALYARALELADTAASKLGASTSLTTTSDDNTTPPNLDISAKQLHLTASTVRKLVLRYRALAELKSSHATSDASSTIPATAPKPAPLIERLSHNQYIPNLDLTNLVNYPPKLRPVPVKPLFFDLAWNYIKYPGQKGPEDDVQAAKEDVQLRDPGAKTTNGPVLETDTKDDRKAPKRGWFGFGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIH5</accession>
    <name>A0A1C1CIH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rrd1</name>
        <name evidence="12" type="ORF">CLCR_04110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIH5"/>
    <dbReference type="STRING" id="86049.A0A1C1CIH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04110"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08399"/>
    <dbReference type="eggNOG" id="KOG2867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="352"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT48252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="456" mass="50266" checksum="1D8F79B46C2C0106" modified="2016-11-02" version="1">MAGFPSLQKILDITTHHFEKPVKKIYDGPDVAFFLTSLAYRDIMTFVLQLNRSVVPRKGHVGEAATTSTSTSTWVLNAEDITFSDAVSRLRALLDKLSRIVDDVPPETGPTRFGNVSFRKWYKIVEDRIDELLADVLPQQMKPASEEIAAYLLGSFGSAQRLDYGTGHELSFLAFLACMWKLDFFSPSEPGVEERGIVLGVFEQYLSVIRKLIKVYNLEPAGSHGVWGLDDNSFLPYIFGSAQLCPAIDETDETPIKGSLVNAPEPSSVTKQNLVEKEKGSNMYFSAIAFIYDVKKGPFWEHSPMLYDISGIKDGWGKINKGMIKMYNAEVLSKFPVVQHFPFGSLFKWEKDPQAKDVPPSTHTQSQPLRNPTDTHAPSTMRPGGPPVGTTAAPWAAKPPAAPIGFANGVTQAPWASRTPAPPLPRGGFAAARRHPMPSVNETGTKPTQQSLDEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIP9</accession>
    <name>A0A1C1CIP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_04325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIP9"/>
    <dbReference type="STRING" id="86049.A0A1C1CIP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04325"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08522"/>
    <dbReference type="eggNOG" id="ENOG502SEH4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="234" mass="25850" checksum="7C0B719E96971516" modified="2016-11-02" version="1">MATELPRAVDTEDREIIEKLAKLQNMYSQVSLPCFSFIGGLRSLLPDKLINPARVALENPGGYEPEKLATYLQTAAKAGSQDVERFKKDWHGDDVRQLWHVVNGNDLPQGGDAWPLDYGALLQDTATNEQTSTTATDPSREFQPPNEPEIMQVVDDFRARHPELRIHVSDGATPLPIDIQVGKLEFRLEQRHSVGGTKYIVLGKPGTEASSLRHNVLQSISESQQGAGLATLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIV9</accession>
    <name>A0A1C1CIV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-arabinitol dehydrogenase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ARD1</name>
        <name evidence="7" type="ORF">CLCR_04131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIV9"/>
    <dbReference type="STRING" id="86049.A0A1C1CIV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04131"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08537"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08234">
        <property type="entry name" value="threonine_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="76"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="205"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="376" mass="40919" checksum="AFC065DCB2A1AAF8" modified="2016-11-02" version="1">MGSADLPTKMKALRYEAPEKFGVVEVPLPKLRDNDILVDADNENIAQSEGVRCVWHRFTYTRGRIFGQGVLPSPTDSKQADLTLTAKFPLIPGHETVGVVVALGSKVKGFSVGDRVVADNSELCGECFYCRRGEELLCEDFQAHGVTMDGGFAEYCAYPAKRVFPIKNLSDVDATLLEPASCAAHGLDKIAPKMGSSVLMFGAGPTGLVLTQMLRQNGGCHVVIAAPEGLKMNLAKSLDAADEYVELSRKDPSAQFEKIKKENPYGFDIVVEATGSVKILEDAINYVRRGGKLVVYGVYGNADRVSWPPSKIFGDEITILGSFSETYKFPAAIDYLDKGKVKVAGIVNKTFKLEQWGECLESMRNKSAIKAAIVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ66</accession>
    <name>A0A1C1CJ66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ66"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ66"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03995"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08631"/>
    <dbReference type="eggNOG" id="ENOG502S69X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="146"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="577" mass="65185" checksum="452AFC3836EA3AAE" modified="2016-11-02" version="1">MATRLPLPKEISDLLIACREAIKKQRYEEAINSITAALHGSIASNTTVTELIGVYDYRHAAYVRQGDLDFALQDAKTMIRLDRNDVRGYLRCSSVNRMMGNLAVALQFLEQGLKHCSEADDLDILLKETQRVRDKLAAERVLTRPRDPVATLPLEVVEFIMSYLDYRQHVRMLRVSTSWKRVLSVLPPLIDTVSFVGAKTHVSSRMMRAALRRIGAPKIVRAVGLTSGASTVLQDWLHRDKSIASLEVLEISDPTIPMRTFSFRSDVLREIALDFPTLCGMEIIQEILRRCTALEYARFTTCVSGEQFPRWTLRSNTLIELDLNCEKNPAEFLRLIIDLPEIRVLSLSGFNDPQWPGDLDLRDSQYLTTLCLYDCAIRDLYLPPTVRHLRMESCEMQTERAPWPAAGPQPMLPGLDNLETLSMLYSFPGARFSEPFLPIIRQSAALTDPGHLKCLKFSYNLSSLDHFEAIIQAKWCLGLTELHIDSPNIVDRCSPFVVRSCPDLEVFHIRGAPITGVFIVDLILAPRSKLRAVTVEDCPRVHKDIIPYGEGRGVHVKFISSAEKVGKGSGRRVRELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJT6</accession>
    <name>A0A1C1CJT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(II)2Cys6 transcription factor acuM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_04835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJT6"/>
    <dbReference type="STRING" id="86049.A0A1C1CJT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04835"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03187"/>
    <dbReference type="eggNOG" id="ENOG502QQGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045722">
        <property type="term" value="P:positive regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053045">
        <property type="entry name" value="Zinc_cluster_trans_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986:SF7">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ERT1/acuK family PAS" evidence="7">
        <location>
            <begin position="337"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="449" mass="50892" checksum="93E52B03279F9DC3" modified="2016-11-02" version="1">MSQDRPCKRCIKRNIGHLCHDEPREGHGYHKKSKTESDTTALDEQSSPTDEFASAPSLPGPALIDDSAPNMLQDDNIGLRPPANDTMAVSNSSTSAPSAAINGNAQAQFGYNEPWPGTQHRFHDMQAFHPNFMFNANEVTDEFNLLNDFLSNSLFEETGMYSTEEFQGPFNDPSFMNSMAASSFPHGGVDTLLPPDQVNHNVSTHQSNAAHAAMISRPPSAKPVSDKAREKYYMMAADPTGQEPPEERMQKLLKAEYDAGMLRPFNYVNGYARLNKYMEKHMKPHSRHKILMQLDQFRPKFRERMQSLTDIELVLVEMWFERSLMEYDRIFASMAIPACCWRRTGEIFRGNKEMAELIQVPIESLRDGKLAIHEIIVEDQLVSYWEKFCAICFDQQQKAMLTSCTLRSPTAGADAEPIHCCFSFTIRRDNHNIPSLIVGNFLPMNPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKT8</accession>
    <name>A0A1C1CKT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05079"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02809"/>
    <dbReference type="OrthoDB" id="4125219at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650926" evidence="1">
        <location>
            <begin position="22"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="250" mass="27392" checksum="A3AE9E1C399CC73E" modified="2016-11-02" version="1">MTSSVRRTLVIGLMLATMVLGQDCGRRVVFTDRGASSNYYNCSGYVDGDMWKYLAWYNGTTTVTLTGGPMSECPDTTWQPLQNSFLIGGMTVPGNASLDRRAYDNNTFYFEIPSKDNDNITVSFQSSSDEWYDEPQGWQLNATKKGDGYDVAGTWIGTLPDNNELDFPGVPGDDCWYGGPYYLGMKGYDNMKWVLEGHVSPTAAEISIIETNIDRDGGVWHIYTNFTGKAGPKGPKLVTAGAAPTTDAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKY4</accession>
    <name>A0A1C1CKY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF427 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKY4"/>
    <dbReference type="STRING" id="86049.A0A1C1CKY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05182"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02805"/>
    <dbReference type="eggNOG" id="ENOG502S4XN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43058:SF1">
        <property type="entry name" value="DUF427 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43058">
        <property type="entry name" value="SLR0655 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="27"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="163" mass="18635" checksum="A8C7A4F74016CFAC" modified="2016-11-02" version="1">MAARPKLNVQNFPRPPLLELTRRHLLIRWNGQTLADTKSAYWVLETTHPPTYYLPKSAVSDAFKLKQVPHKASLCEWKGRATYWEVTDNSTGETVKNKVWSYESPTPAFKDIKGYLSFYASDVPWECFVDDEKVTPQEGDYYGGWVTSELEGPMKGGPGTWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLS7</accession>
    <name>A0A1C1CLS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04967"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03325"/>
    <dbReference type="eggNOG" id="ENOG502T27G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5366332at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="373" mass="41608" checksum="ECDD6800F797A394" modified="2016-11-02" version="1">MTIRSMSYQCETKTTTSDRRDESDAESFHSAMSTVTRRSCKGLSSKLNENAGRTDAILKPENAPTRPRSKISQRSSSSQKSQSRSRARSLRQDSIPIPRRRSSLPKQKHRPRRDSATLHHQSCQLFSSLDGMLAMSRDITPLPSVATSRTTTRHASLVPDGTFDPDSIKRVCEKIDARLATAADPEGEAQPVAYPFAYEYTYALPAGSIDNSPTLPYGFNTSVDEHSSLLSRAMTAPTIKAPQRPQLNTVISWTSNATRRTEYEKIDRAHSGVRGLVRRVWPQCLRRRNGRRGFFTGDCDGDSVRRFRMDVSEDDDSDAENENGQSFDHGVVDEKIVLEVVNTRGLRSDGPGKVAPTGKEAKTRKPWLSCFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM33</accession>
    <name>A0A1C1CM33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM33"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07836"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="79" mass="8730" checksum="BD283658B7693A78" modified="2016-11-02" version="1">MTSGEIQLFLATSASSEISFARRGIMMSRSRQPMHTGSETTQRATARNMRPVGEYNVYPRYVGQAHVSLAVMNVLPLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM50</accession>
    <name>A0A1C1CM50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="11">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">bxlB</name>
        <name evidence="14" type="ORF">CLCR_06670</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="11"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM50"/>
    <dbReference type="STRING" id="86049.A0A1C1CM50"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06670"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09847"/>
    <dbReference type="eggNOG" id="ENOG502QQ55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650903" description="xylan 1,4-beta-xylosidase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="677"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT49590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="770" mass="83751" checksum="7E0A8388B477ED2C" modified="2016-11-02" version="1">MAATLLGLCALLAAPAAAALFPDCANGPLANNTVCDTTASVAARARALVDALNIDEKFNLTGSTSPGVPRLGLYSYQWWQEALHGVASSPGVTFAPNGDYSYATSFPQPILMGAAFDDALIHAVATVVSTEARAFNNANRSGLDFWTPNINPYKAGRDPRWGRGQETPGEDPFHLKSYVASLISGLEGGPDSKFKKVIATCKHFAAYDLEDWGTTDRYNFDAQVNTQELAEYYMQPFQTCARDSNVGSIMCSYNALNGVPTCADPYILQTLLREHWNWTGEGQYVTSDCDAIQNIYMPHDYTATREQAVAEALKAGTDLNCGTYYQTHLPVAYDQGLFDQSVIDQALIRLYSSLIRVGYFDPASATPYRSLDFRNVSTPESEALALKAAEEGIVLLKNDGILPLSLPSGRKTNITLLGGWANVTTQLQGNYFGVARFLHAPLYSLQQLPNVNVRYTSSQGSIQFPTTGNWEQLVTAAEDTDLIIVADGINTNDESESNDRYDISWSPGKIDLINQIATLGTPVIILQFGDQLDNTPFLNNPNISAILWGGYPGMAGGDAVVNILTGKTKPAGRLPVTQYPSDYVNQVDMTDMNLRPNASSGNPGRTYKWYDHAVLPFGHGLHYTNFSVDVVASSQTTYNISQLVSSCDRSRYKYLDLCPLDSFQVNVTNTGSVASDFVTLGFISGQNGPRPYPIKELVAYQRLFNIAGGSSQTAALNLTLGSIARRDVNGNQILYPGDYGLLVDVPTQATWNFTLSGSPATLDQWPQRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM80</accession>
    <name>A0A1C1CM80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM80"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07652"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="187" mass="20675" checksum="6876BA83F5A517AD" modified="2016-11-02" version="1">MPAKTPDPARPKGRSTKAATGRLSYDSVVKKRSIDVVDHTVLDASSITKRVRRLHPLRVDDVDTSLPTGESSSPALLQIPPVFAVQDTVFDLLPPAGLSLAEEVIDRWKQLEKKKYQWGKETTNKKSAHLTSDADWRRGVDTKVLTKEQFQALFLPAADAERGDGEGVYVPSFTVSPPRSESARRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNB7</accession>
    <name>A0A1C1CNB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cyp6</name>
        <name evidence="14" type="ORF">CLCR_07107</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNB7"/>
    <dbReference type="STRING" id="86049.A0A1C1CNB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07107"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08927"/>
    <dbReference type="eggNOG" id="KOG0415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000377">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="26"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="231"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="319"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="394"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT50018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="451" mass="50931" checksum="93127B8E6E9ED1B2" modified="2016-11-02" version="1">MSVLLETSLGEIVIDLLVNSAPKCCENVQKGFTCQTGDPLGPDSPESDGGSSIWGLLSGSSKKSFVADIDPKLKHTERGTVSMATVPSARDPDERLAGSQFIITLGENIDYLDGKAAPFGMVVEGFDTLEKINDAFTNADGRPLKDIRIRHTIILEDPYPDPPGLVVPDASPAPTKAQLATVMIADDEDLDEEVDEAAMEKLRREREARAQALTLEMVGDLPFAEVKPPENVLFVCKLNPVTHDEDLELIFSRFGKILSCEVIRDKRTGDSLQYAFIEFENQKDCEQAYFKMQGVLIDDHRIHVDFSQSVSKLSDTWRDATNSKRQRQAGGFGGIASLEKKRHYRDEATREQNGRGYRMVFDKDDVRRKEDGRSEMGSRRSRSRSPQYHHHRASTRDDRRTRDMDKYDGRDRRERDHYPGGGKDSGRGSERDRPRESRGESYRSSRRDRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNC0</accession>
    <name>A0A1C1CNC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase AflY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aflY</name>
        <name evidence="2" type="ORF">CLCR_07111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNC0"/>
    <dbReference type="STRING" id="86049.A0A1C1CNC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07111"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08899"/>
    <dbReference type="eggNOG" id="ENOG502S69W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF7">
        <property type="entry name" value="BAEYER-VILLIGER OXIDASE MDPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="481" mass="53934" checksum="95A48B5FD980B1E7" modified="2016-11-02" version="1">MGSLIESSTTEVLFAAAGLNGKGFVQDDNAPPTTIRLQPAPFDDTLGLARIDANPAGSVDLVAELLQKNHEKWHMYFRDVAGHNHIPHAILSTFAMGGGPQELHRAYDDGESIQRPMPPVSPQAVQEMRDPVRFRERMHILDQYPNFLAFFEQEIAAKGGDWQAVVLEHCFARTPLSDLMMAQLFEGLYHPFIHLGFGVEFSLSGLVAEGLAQTASHDPMYIDVFFQKAEKLARAGSVARQPLMDLYRQTRANDVIRTAPRMPDGPWKVRDGVLGRAMDEVVRVAAQFQVEPTEEDVERATAEMISCAAWSCAASHKPGKERKIDFFLMHAVTSSIFVTVLARQSWIPIADKARMVEWKARLDLVWYAASAAPELRDEFIVDYEPTLSKGMGWPQLYQALNRHHDDGHVAKFVRAIKNGREVAAPFEQSHASSFPIKGDLWLKVAQLCYDSTVMYVEGEKKWVWGAGFEPMWAKVRDEVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNE7</accession>
    <name>A0A1C1CNE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">UAP1</name>
        <name evidence="8" type="ORF">CLCR_07042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNE7"/>
    <dbReference type="STRING" id="86049.A0A1C1CNE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07042"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08926"/>
    <dbReference type="eggNOG" id="KOG2388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="511" mass="56338" checksum="9E7D1F0C64394ACB" modified="2016-11-02" version="1">MAANMVNKMLEKLNLASKDRGAPAREPTDEELKSLRQKYEKANQEHVFAFYDDLDTDGKGALFEQLSGFDPDRINILADKALHPPKDSEQTPSINPLPESATASLLESTEEQKEKWYKEGLSLIAQNKVAVVLMAGGQGTRLGSSDPKGCFDIGLPSHKSLFQMQAERIWKVQQLAKQHASASATPIVPWYVMTSGPTRAPTEKFFQEHNYFGLDKANVVIFEQGVLPCISNEGKILMESKSKVAVAPDGNGGIYQALVLSEARADMRKRGIEHVHAYCVDNCLVKVADPVFVGFAASKGVDIGTKVVRKRAANEPVGLIVEKNGKPDVVEYSEIDQEMAEAKDTGDRLKFRAANIVNHYYSFRFLEAIEEWGHKLPHHVAKKKIPFMDTETGETVKPEKPNGIKLEQFVFDVFPFVPMEKFACLEVDRKEEFSPLKNARGSAEDNPDTSKADIMDQGARWLQAAGATVVSEGTAKGVEVSPLISYGGEGLGYLKGREIKAPAVIEKSPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNJ8</accession>
    <name>A0A1C1CNJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_06917</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06917"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08931"/>
    <dbReference type="eggNOG" id="ENOG502QTZH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10027823at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="27"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT50021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="578" mass="63742" checksum="3E2D6CDADC1D4ED6" modified="2016-11-02" version="1">MASISAFFHWLHRETGLQSMREYGNRDIYLILVTRFLRMFAYGGAALVLAIFLYTQAGVSWKQTGTFMTLTLLGDAAISYSLTILADKVGRRRILLIGSLLMTLSGTVFAFSKNYYVLLLAAVFGVISPGAHEVGPFRAVEEGILAQLAPLEARTDIFAWFAVSSTLAMAFGLFVTGWITYAQRTYLKIDWKETYPPVFGMYAIIGLIKFLVTLLLSKNIEARAAGQYSWAATTASMTEVDEEVASPSEQTRPLLDGTPRRSSAAKQPNITRTTSIRSGSSQSQPQRRQSDSLFGRLRTSLSSPWKVSRSSLPILLRLSCLFGLNAFASGMLPLTVMSWYMSWRSHWFLTHRIGYALSLVWLAASLSNLFSAAVARRLGLVKAMVCTHLPSAVFLALVPLGLIVSGWRLLIFLLLGDAVFGSMDQAPREAFVAAVFLPRERTQVMGTLNFVRTLGACLGPVVTGVVASKERWWVPFEIAASLKIIYDVGLLIMFLRTPLPEEHRRVVLDGNQRGTDQHGVGMTAAEMDVNVLMDQLQSGESGGLAHPSDFDVSDDEDEDEDGDRGDLGQYKPLVREVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNQ4</accession>
    <name>A0A1C1CNQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNQ4"/>
    <dbReference type="STRING" id="86049.A0A1C1CNQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07513"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09027"/>
    <dbReference type="eggNOG" id="ENOG502RY15">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF3">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="268" mass="29927" checksum="6CB12A99C698CF38" modified="2016-11-02" version="1">MGQTASQPEGGKTLKVIGAGLSRTGTTSFGAACSELLDGPCYHGGTQMLNSPEAHIKRWIDIIRHTPVKGEADRKALHEGVKEMLDGYVACTDLPSNAFVEELMEIYPDAKVICTVRDPDKWWNSLAPIVEKGNLTVLSWILAPLPTLRWFRTYHDVLDEGRVGELYFRPGEPQRPTRAMWDRHIEHLKKVVPKEKLFFYDVRDGWEPLCAILGVPVPKDVPFPKLNDAAAMETFMKKSAQRGMMAWAGIFLSVGVAAYTAGRYAHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNY0</accession>
    <name>A0A1C1CNY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative beta-carotene dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_06946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNY0"/>
    <dbReference type="STRING" id="86049.A0A1C1CNY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06946"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05790"/>
    <dbReference type="eggNOG" id="KOG1285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407010at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT50192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="569" mass="62821" checksum="AC51DEFA604D87EC" modified="2016-11-02" version="1">MGDAGSLAGEKVAPTLHYNDWPNTLGFDTHYEERTPVELRVEGDIPAYAAGTLFRTGLGPRTIRTAKDADFKVNHWFDNFSQVHRFQIHPPQPGAKARVTYNSRLTSDGLIEKIRKTGKLDGFTFAARYDPCKSFFQKMQAVFQPAQPEPKPNEVNVGVTMSANFPGLSRDGHKTERPRDARDGMTLCNKTDANMLQFLDPETLEPIGVAHQATLHPALTGVGSGAHAKSDPATGDVFNYNLDFGRTGTYRVWRASASTGKTSILATFHHAPAYIHSLFLTENYVVLCVWNSYYKAGGASILWTRNLLDAMAWDGKRSTTWFIIDKKSPEEGGKGVIASYESKALFSFHSINAYEEPSTSQQGAVDVICDLVAYENMDVLHHFYLDNIISDLPQAHSARKSMPFTAVPNYRRYRLPGISSTPKTKHMQAMQDFEGSKANAFELPIINPMMVTKKHRYMYGISDTGKSTFVDGLVKYDAETHTTLRWSVHGQSPGEPIFVADPRSDDEDGGVLLSVVLDGPGGKSYLLVLDAKTMTEVGRAHVDGAIGFGFHGLHVSSRTPVGRQNGLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPU3</accession>
    <name>A0A1C1CPU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_06802</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPU3"/>
    <dbReference type="STRING" id="86049.A0A1C1CPU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06802"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05489"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="274"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="606"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="548"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="675" mass="74689" checksum="75A8B0B5AABDD270" modified="2016-11-02" version="1">MAKRKQPETDIESDPEHSATDTPSKRRRRTAEAAEALTNGRHRDENEAPGTNGSSEKQETPSRRIRRPTAKARALLEAENDEGSPTPKVNGRTLFATPRRTKDTVATVTPSRSVKAKADRSAKRKSARLIAEAQTEVDEDVDEDEDGLQERDRRLAREILDEDEHTDEEDIEEAELDRNVERHISDAEDTATATTPTPTPRKRGRPRTAIKTQSTKPVRSPTPEGDIPPEERYFYQTRPGAPQVSSNRFNSVKLLTQEEYFDQIASWKDPHAPEKAFLSNLHARAFPQWKAELDEGYSLCLYGYGSKRSLVTRFAEWVYKRCNSDSDSASTSASASASATAPQIIILNGYVLKLNIRNILNTIASASTAGADHGHEDEHDGPKLTGQPEEMLDGLLAHLTSNPPPQGALYVMVNSIDGPSLRRAGMQSLLARLAAHPGVRFVCTADSPLFPTMWNSTHLEHFRFVYHDCTTFAPYEAETETGAGAGAGAGTGAVDQVHDLLGKKRSRAGGKEGVGFVLKSLPENARNLYRLLLTEILTLMEEGLDNWDGTVADDADEDGDEYQGRDDDSADDDPAPRTRKRKTKKKTKTETKTKKTKAKVSEPSAAEEVGVEYRALYRKAAEEFICSSAMNFQFLLKEFLDHQMITSRRDGVSGAEMLGVPLGREEMLAVLEELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ53</accession>
    <name>A0A1C1CQ53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">tif222</name>
        <name evidence="11" type="ORF">CLCR_07104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ53"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ53"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07104"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05403"/>
    <dbReference type="eggNOG" id="KOG1465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT50612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="471" mass="50813" checksum="A7EC7F4472351F0F" modified="2016-11-02" version="1">MAPTTAPATPGFATFQKVLSTEPLESATAYLVSLLKRRQLKGSKRCAVVTTLLLLRTVEVTKQADSERLIQRVKEVGKQLIEAAPHEPAVGNIVRRVLSIIREEDEEDAAGQRGGDDGASVADDSPLETPSETPQHLRSSVFHTLPNGLSSSSPSPQRGPGSSRPPLLTSRTGAAETAARPVTSMFSINAHPTMRHLGGVDSPSNRSGTGTPQLGASGLLPNLRPEVIHGIKEIIDEINGADDEISAAALDQIHPQESIFTYSSSLTVQRFLLRAASKRKFTVIHAEAYPNNHQQTHALLTGNQDVIAEDEDNLPNDTFSKTLTSAGITVVMIPDSAIFAAMSRASKVVLDAHAVLEDGSIVAAAGSKAVVKAAKFYRKPVMVLAPTYKLSPAYPYDPFHLIEYGDAGRVVPFQDGELRRGLDTSVRNALYDFVEAADIDLFVTNQVPAVVSTCYLYRVVRDQYDEEDVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ61</accession>
    <name>A0A1C1CQ61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carnitinyl-CoA dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">caiD</name>
        <name evidence="8" type="ORF">CLCR_07463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ61"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ61"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07463"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05414"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000074">
        <property type="entry name" value="Enoyl-CoA hydratase (AFU_orthologue AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF158">
        <property type="entry name" value="ENOYL-COA HYDRATASE (AFU_ORTHOLOGUE AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="293" mass="31290" checksum="3175630022F0B5EA" modified="2016-11-02" version="1">MPAYPSSLGTPPPSTPKTILLFPTPDTLLVVLNNPRGLNCLSTSMHYALHGLFEWYDNEPSLRCAVITGAGRAFCAGADLKEWNENNAARAAGKSAGDGRRETPRSGFGGISRRMGKKPIIGAINGLAFGGGMEMVANMDLVVAARSAQFALPEVKRGVIALAGALPRLVRTLGKPRAMEMALTGRTVSAAEADAWGMVNFVTDDAPVDADVLERPVVKKALEYAKEIAGNSPDSVIISRAGIIQGWEDGSAEHATQSIVDIYSKRLNEGENIHEGVRAFVEKRAPRWVPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQR3</accession>
    <name>A0A1C1CQR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07727"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05210"/>
    <dbReference type="OrthoDB" id="4087970at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019434">
        <property type="entry name" value="DUF2423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219:SF1">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10338">
        <property type="entry name" value="YBL028C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2423" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="147" mass="16477" checksum="1404E168D1DEB516" modified="2016-11-02" version="1">MAKSARATVVKKNRRALRATVFGPAHDARTARLSAKLQELAAKPKPETEKAMDVDERNGEDAEDQPRTDGNEGIVFRLLKPYQTLTSIVEMDIDAQGAKMKAVRSAPGKNRVNRKAHKISKKKPRNSMVFPSEIARRKKMAIKKTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQS0</accession>
    <name>A0A1C1CQS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQS0"/>
    <dbReference type="STRING" id="86049.A0A1C1CQS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07930"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09502"/>
    <dbReference type="eggNOG" id="ENOG502SAWK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3521097at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="566"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="819"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="994"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="883"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1144" mass="126195" checksum="6B6575736E43C81C" modified="2016-11-02" version="1">MAELALRGRDQPDIRARISIHDDESPKDIKELQLADQTQRALRSKHSWTPPEAVGALHRAALRKARTLPYPYRPGHFSNIPASDALPCPIIRSNSLNSLSTIQRETEAASLSLYRGSPISAISPSYAAPSWTVSIDEELQDPCPPRLPLRVETLSQQRKVQKRLKKSLKKQEKEQAKAQKEEEQLRRAFLAADVAAARRKDAAARGESLPLRTKSTRSIASQVVKSLSLKSPLSKLSRRVRRDKAEPPTLDDFDSKSAIREYLNPSPPPPPASLSPPSAGIAELPAELPQYTPFQDSTRTQDNEPVALLADAYPAKEKDLVASPVTENNPDATSSQPKAKSMRCDSCQSPIRLSQVYYHCSICDDGDRILCSSCDQAGWSCRHDLTEKVRSVSRPDAGEKTTASDVIREPSRSEAEQYAAAMWGLKMPGVSVRSGRWTESPMEATISAASPWAFNDIVEQNKLQAAEMRDMSTQQPSEDARELDYRRRELEMEFRDRQIAMREKETALREQQASFREQEAALHVKQQMFSMQLETAIARQMTELSAGVGTQFEELSQHDGIRTHATKRKAGAGQPMVSPANSTNSDQKQSPKRSQDAEEDDEEDAPGGTPKKIKQESDALQTPEKLFACPFCKFDKSKYSEQNVQEKQYRGCSSGYWPDISRLKQHLYRVHWRRIHCTRCYARFERKDQLDQHRRAATSCSLVDCPYPEKFDEAQYNEIRRKRPASTPEQVWYTIYGILFPDLPRPASPYADNVDMPFAVSPGPTDTRDTMDVLGEVFESRLDRLTNAPGQGWLQSAEARQLIREQLRASMTDVLHRLRPANSPSLGNPSGDVSPISAGAPDSARRSSICLTTPASSTPPSPVHGPGSANRTGSDMHFLSPGHRQSFSRPFSARTVPQLSTPQPPQKIGLRDELTSAVTFPVPMIIDPENDRYDEECSSWSHGDERGLAISTDSMPADFNFDFAATFEDLHNTEMGSASAAMPEFTPVKLASLDDPAAQPSKGSSALKPKHSTTSSVDSGYGSLGHASSSASASTSVSSSVPGSSPKTAQHGRNKGKRKAAQAAREPTPVPESAINYDALEVPFQDFSGVNLDLDLEEHLGQYGVDFGHFSGGGNVNVNTGAANVSAYLDRRYPRAVREAGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQW4</accession>
    <name>A0A1C1CQW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08694"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09523"/>
    <dbReference type="eggNOG" id="ENOG502STXT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4156665at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="394" mass="44838" checksum="D798DEBC84C24E3E" modified="2016-11-02" version="1">MDPSSPKSPMPSLSPRSPHSPMAMDTPMISPLPQLVTSFSPEHMLHRQASISAMLMTPRSGGNPAPWRLSNGSTCRRNSLTSPITSPVYSTYSIRTPERSYFHKVHMQTPATATFPQDGRRSRMAMRSPRHGRGTTMTLPLRVNTNLPNVQEEDSSSTRFPSDSSPIDWAPTTTTTATVLTTSATNPRRLIRSHTPTPITTRSPIRKRPRLSRCPGAGRLPQPPRYHVTVVPPAASPRTQRQRQNYQHSVDHLRTPLVPLISVATGLPHPQFPTTLLQYHLLTHDQLDSLARWYHQVEPAVQETFLYPACIPAWTSLHDEDRQIDVDLETKRRRWGRFIGLRGCESPGTETDEHGNPLETREELARRMEREWRRALERAEEESRAFEKSWRGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR44</accession>
    <name>A0A1C1CR44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_09013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR44"/>
    <dbReference type="STRING" id="86049.A0A1C1CR44"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09013"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09624"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF112">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G02370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="77"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT50984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="220" mass="24051" checksum="B83B37889D0069B8" modified="2016-11-02" version="1">MAPWTHLLRFLAEEDGQGHLGQVDSKKWPDVGLAIYNGERVDVKLVTGSVFDGVVTNTTMHISKLLPPLEISEVPIIRCLGLNYYEAAKEAKAPVPEVPVLFVRPRTALNGPYPAAINIPKIAQDGTSDYEAELSIVLSRTGRDISEDEAMDYVLGYTCSNDVSARTQQFKNSQWSFSKGLDGSCPIGPILVAPSVIEDPHNLKIRAIYNDGVVQDANTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CR89</accession>
    <name>A0A1C1CR89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-tubulin suppressor protein Aats1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CR89"/>
    <dbReference type="STRING" id="86049.A0A1C1CR89"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08582"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09661"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF5">
        <property type="entry name" value="RCC DOMAIN-CONTAINING PROTEIN ATS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="248"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="351"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="47789" checksum="CBF5A8E8C0CD75D1" modified="2016-11-02" version="1">MPAAAHSNTLSIYALGSNSSGQLGVGHAEDVSSIPQRCIFAVEDEAEIELEIELEVSDDQKAHGGGGRPPPRPTRRRDQDLDPSVVGDIRKIVAGGNRTVVLTNRGRVFIAGHVAGGLRSVRGEADDNIFREVTQGILEFCAREGEGEGEDHGEAITDVAACWDVSFAVVGGRVVVCWGDVGGTCSVSATTTSSSITPAATTSPTTSATRAQQMWTAFVINYTDAKDNVTIAAIEAGMAHVVVLLSNGQVYGWGTSRKGQLGEQFQREKILRHARRLDVEPDGRRILPFAPERVILGREYTVFLRRGEKLVIWGSMSGKRDAEWLFGQDDMAVSGWSSVHVLSPSGGSSSAVVESMGKNNHGQFAPADLPSIRTMAAGSEHCVALTVEGQVIAWGWGEHGNCGEQVDGKGNVVDRWNVIALPQLDQGTVVRDVAAGCATTFVICGADER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRW5</accession>
    <name>A0A1C1CRW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRW5"/>
    <dbReference type="STRING" id="86049.A0A1C1CRW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08135"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06847"/>
    <dbReference type="eggNOG" id="KOG2598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.910.10:FF:000003">
        <property type="entry name" value="Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000034">
        <property type="entry name" value="Putative hydroxymethylpyrimidine/ phosphomethylpyrimidine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="2">
        <location>
            <begin position="327"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="560" mass="60996" checksum="2FE7EE1F5553C16B" modified="2016-11-02" version="1">MTLPRVLVIAGSDSSGGAGLEADQKVLAAHGCYAMTATTALTAQNTLGVDDIHITPPAFVGKQIDACLTDIGSDAVKIGMLASADTIKVVAEALQRHQVSNIITDPRPNRLTALQVMVSTSDAQLLPGDAVRNLREKLLPISTLLTPNIPEATLLLRDADIQYKSPANLDDLKILAKMVHQLGPQAVLLKGGHMPLTKSYTKATTDAERALTVDILYDGTTLTTIESPYLTVKNTHGTGCSLASAIASNLALQVSSKASKESPSEPPPSLAVALPLATRKAVHYVSSGIKLSDPTLGRGAGPINHFHSLHILPFSPGHFIDTHLLVHPTVRGPWHRYTHHAFPAAMATGTLPEGLFKNYLVQDYLYLTHFARTHALAAYKSRSMPAIAASAHIILHIQREMALHLSYCAEFGISQTELDDPARTTESLACTAYSRYVLDVGASQDWLALQMALAPCLLGYAVTAARLHADPASVRGTDRNPYWRWIENYVAEDYCEAVRVGRELIETNIVKQSPARIEELVAIFVRATEMEVRFWDFDAHSNEKEEEEEEEEKEGRKRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRZ0</accession>
    <name>A0A1C1CRZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Plasma membrane stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_08075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRZ0"/>
    <dbReference type="STRING" id="86049.A0A1C1CRZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08075"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06812"/>
    <dbReference type="eggNOG" id="KOG2513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="11"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="170"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT51270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="745" mass="84635" checksum="1CF7E07590727369" modified="2016-11-02" version="1">MAHKTLQTNFDVDYVISYRMPKDEGKEAGITQFRKLIRALAETGLTTEVRRGDETSLLVFIKASDEKILADVVHRSRIKDWLHGVRQIQPSNDVANILTSEPLTDAERLRHIHHMICCPREEGGAGITPKHGEWKNVEAVFPLHDHVKNKKWLTEFTRKTFLTPDDLDEIRNTVGEKIAYYYAFLQSYFSFMIFPAAFGFSCWVLLGNFSPIYAIVNGLWCVVFVEYWKRQEQELAIRWNVKNVSLIEDKRREFAPEKVTTDPVTGEQIWFFPAKKRLQRQLLQLPLAALCVVGLGAIICTCYAIEIFISEVYDGPLKSILVFLPTILLTLAVPTMSNFLTGFAEKLTYYENYETQDAHDKAMVSKVFVINFITSYTAIFLTSFVYVPFASILVPYLDVFSMTVRPFAENEKQLQTPSPATFSINPNRLRNQMIYFAVTAQVVNFAMETVMPVVTQRGTKKFKEMQSQRAEKHGGATPSVADHDPPEEKEFLARVREEAALPDYDVTSDLREMCIQFGYLSCFSVIWPLTPVSYFINNWIELRGDTFKLAVECRRPNPARADSIGPWLDSLEFLAWLGSITSAALVYMFSGGDGHGPDGRPHQIKLWALLLSVFLSEHIFLVVRVLVRTAISKLDSAAMRKERSERFMVRRKYLEDAGLGHAVKPIASPPNSPLKTESGEQAFASITRQSLEEDARNQSTSTSGGVEGATERFWLRQRSWAESERVGLGMIELMDLGTEKAKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSN8</accession>
    <name>A0A1C1CSN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulfite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSN8"/>
    <dbReference type="STRING" id="86049.A0A1C1CSN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08743"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06584"/>
    <dbReference type="eggNOG" id="KOG0535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="2">
        <location>
            <begin position="78"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="3">
        <location>
            <begin position="243"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="352" mass="39658" checksum="34A1E4B4E6F51FF1" modified="2016-11-02" version="1">MEASHDCRFPQAEQPDEESTYSQYVDFRTAASSEHSGSELNALEAIDPAGFFIRHPPKPHELEAELTDETQLFQTIHMGAAVVDEKRWRLVMDGLVEQPFTISFEQLKSMPRTTITAFHECYGSPITPPIHALWRIGNVKWTGVRLSDLLKLARPNPRARFIWSQGLDAGSFAGVSAHSYEKDLPLEKAQRPEVLIAYEMNGERLNKKRGGPDRRAPGPFTTTFYNEVDPTDPTGQSMRPVWMVEPNSMIVGPEPGAILQGPQIEISGRAWGCQEIEGVDISIDGGETWLPRPVVDLRPRREFEWQLFRAKLSLPEPGKYKLVARARDTSGLSQPLAGRRNHVHTVEVEVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT13</accession>
    <name>A0A1C1CT13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoadenylyl-sulfate reductase (thioredoxin)</fullName>
            <ecNumber evidence="3">1.8.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphoadenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PAPS reductase, thioredoxin dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PAdoPS reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">sA</name>
        <name evidence="15" type="ORF">CLCR_08905</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[thioredoxin]-disulfide + sulfite + adenosine 3',5'-bisphosphate + 2 H(+) = [thioredoxin]-dithiol + 3'-phosphoadenylyl sulfate</text>
            <dbReference type="Rhea" id="RHEA:11724"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="EC" id="1.8.4.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.8" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT13"/>
    <dbReference type="STRING" id="86049.A0A1C1CT13"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08905"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06451"/>
    <dbReference type="eggNOG" id="KOG0189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000151">
        <property type="entry name" value="Phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="71"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCT51648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="307" mass="35027" checksum="7FA3CB28E3D7D40A" modified="2016-11-02" version="1">MSVRANSPCGSGRSSPSLEGADSGYASGTNSESDMPELYFTKPHLRFLNRQLQFLEPQEILRWAITTIPNLYQTTAFGLTGLVSLDMLSKLKVPRPQMVDLVFLDTLHHFPETLELVERVQARYPLVNIHTFKPAGVETAEEFKEKYGDRLWETDDNRYDYLVKVEPAQRAYRELNAYAVLTGRRRSQGGARGSLDIIEVDEAGLLKINPLANWTFEQIKQYIDENDVPYNSLLDKGYKSVGDWHSTQPVKVGEDERAGRWKGQQKTECGIHNPRSKYAQFLMEQEKQREREALEQALAKVSLEGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT17</accession>
    <name>A0A1C1CT17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09113"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06458"/>
    <dbReference type="eggNOG" id="ENOG502S2WW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2344991at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013879">
        <property type="entry name" value="DUF1761"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638:SF1">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08570">
        <property type="entry name" value="DUF1761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="151" mass="15838" checksum="C76B076CF9BD93BC" modified="2016-11-02" version="1">MATLHYLPPVKPSAIALGIVFNQAASAGVLAPLFGDTYHRAKAADSKEEFFKSKETATAAASWGSSIVGSAIQTYGVAALINATGTLSYKGAAYLGGLIFAATYSPSLVSQVVVEQRPLDTVAVGVLTRVFETVGLSLFLTYWGTRTNPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTA0</accession>
    <name>A0A1C1CTA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09080"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06383"/>
    <dbReference type="OrthoDB" id="4159375at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="203" mass="22649" checksum="28E198F79CFFCA62" modified="2016-11-02" version="1">MLSQPVPVTTPHQQEKTAAAEEVKDRAYVSDYNETDYSDFLYLAPPLTAEFLPLAPNTADQAAALGVGVKKAKVRPAETFNTGTTPPPSTPADGCEKEYFSATYPPSGARTPKPEAAQAVAAAERRERRPSFVQVTPVKVHHDHDTHKDAHRQKRHSHSSSHSSEPMNWWPEDESVAQHEWVDEGLEEEDVIEEEVWSDAFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTC1</accession>
    <name>A0A1C1CTC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTC1"/>
    <dbReference type="STRING" id="86049.A0A1C1CTC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09002"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06358"/>
    <dbReference type="eggNOG" id="ENOG502S92A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5426165at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="265" mass="29476" checksum="C7FE7A339B51C03A" modified="2016-11-02" version="1">MQLRPASNLSSSGSRKFVIGNRPRNSQRHQRVEVQSDINPLERMEAHRRLHSAESGQLHPRDRRYSEVGETIPLSSSTAESEDSDDSMSRALSWPTRDGTINLGKQLSRRVQRMEGPSPVPFRAFVESLPTTKLPPSAWTDRTQARIEAKVPCSKANDSTSKTSRHTPKSSTSSTTSTMGPTSPPSDLLSIANTRSRRVNDGFEVLPAGTLEKESKVKEFGTWHESLGSQKKPRKLQKRPRSDSASLSSTESHRLSSDSFRPPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTX7</accession>
    <name>A0A1C1CTX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NIPSNAP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_08713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTX7"/>
    <dbReference type="STRING" id="86049.A0A1C1CTX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08713"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06208"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000037">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="166"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="272"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="371" mass="42064" checksum="32B4705AE0728071" modified="2016-11-02" version="1">MSPTMLARRLLPHSPSSQTSLVRAFTSSALLREPRRSPAMSDITPDSAEIFNQKQKEFRDGLEAARKRKEQADSQSPAASTSKPSPSATAAASHLSESLGLGSLSTAASTEEARQAETDTSTKRSGALSSLIYGTPEGRNLDKEMERSFSQVLARGKYVHSIVFHDVKPDKVDEYVELVGNWYPRMANDPEKKVHLVGSWRTEVGDCETFVHIWEYQRYTGYHGSLHSIQHHPEFPVFEKKLNTLITSKKIDLMQEFSFWPTTPPRKLGGLFELRSYTLHPGNLLEWETHWRKGLKARREVMEGVGAWFVQIGDLNTVHHLWQFADLEERKLRREMSWGIEGWGDTVHKTVPLIQTMKSKILIPMPWSPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU26</accession>
    <name>A0A1C1CU26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">csnB</name>
        <name evidence="11" type="ORF">CLCR_08369</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU26"/>
    <dbReference type="STRING" id="86049.A0A1C1CU26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08369"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06124"/>
    <dbReference type="eggNOG" id="KOG1464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000006">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="10">
        <location>
            <begin position="262"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT52006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="509" mass="57635" checksum="6DCD882229C26449" modified="2016-11-02" version="1">MSDDDDFMQESDPEQYDFEYEDDDDVDAGDASVDIENKYYNAKQLKVESPQEAIDEFLGVPALEDEKGDWGFKGLKQAIKLEFALGRYDDAVKHYKELLTYVKSAVTRNYSEKSINNMLDYIEKVTGQQADASATDSTAYKSMEEFYSLTLSTFQATNNERLALKTNLKLAKLYLDKKDYNQLTNKVREIHQACQKEDGTDDPGKGTYSLEAYALEIQMYAEMKNNKRLKSLYQKALTVRSAVPHPKVQGVIRECGGKMHMSEENWKEAQSDFFESFKNYDEAGSMQRIQVLKYLVLTTMLMKSTINPFDSQETKPYKNDPRISAMTDLVDAYQRDDIFRYESILKDNQDLLADPFIAENIDEVSRNMRTKAILMLIAPYTRFTLQFIAERIKIPVSEVQDILGVLIVDKKLQAKINQQNGTVEVEDSQGSDKEHLNRLRDWTSAVETLWTTVLNDGDGFKLEDAQGGAGFPGMNFPMGFDPAGPIPSRGPGRRGAARGRGGGKLVAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUK6</accession>
    <name>A0A1C1CUK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein ERP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ERP1</name>
        <name evidence="10" type="ORF">CLCR_08783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUK6"/>
    <dbReference type="STRING" id="86049.A0A1C1CUK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08783"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05973"/>
    <dbReference type="eggNOG" id="KOG1690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651056" evidence="8">
        <location>
            <begin position="22"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="31"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT52182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="231" mass="25731" checksum="F0E428411E9F8C86" modified="2016-11-02" version="1">MKLLSAALAVALTSLISSSQALYFYLDGTTPKCFYEDLAKGTLVVGTYRAEAFNRQSQTFGPTPDLNMHFTVEETFDNDHRVVTQTTSSSSIPSKFTFSAADSGLHRLCFTPSGPAAISVNGWFSGGTGNILGGVKLTIDMAIGETGKIESEDKDKIDTIVQKVRELNDRMQHIRREQLFQREREVEFRDQSEAVNARIVRWTLIQLGVLGVTCAWQLSHLRAFFIKQKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV65</accession>
    <name>A0A1C1CV65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV65"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11421"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="82" mass="9426" checksum="1218518E3679D214" modified="2016-11-02" version="1">MQATPCPVKNKDKIKDKIKDKIKDKIKDKIKDKIKNKNAFHFRPASPAFFSAFWVRTPHEVDAAVIEPLLCLPTRLADHLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV83</accession>
    <name>A0A1C1CV83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine carboxypeptidase S28 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_10009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV83"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10009"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03801"/>
    <dbReference type="eggNOG" id="KOG2182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000251">
        <property type="entry name" value="Extracelular serine carboxypeptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651088" evidence="6">
        <location>
            <begin position="19"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT52397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="539" mass="59406" checksum="0468143B99B4E443" modified="2016-11-02" version="1">MKGFLTFLAAASCVVVQATNLAPAPLRVLARQAEDVDPTELYPAHYLDVPVDHFHNASRYEPHSNKTFKLRYYFDATYYKPGGPVIVLQSGETDASTRLPYLQKGIVYQLASALNGIGVILEHRYYGKSFPTPDLSTKNLRFLSTDQAVADQAYFASNVVFPGLEDQKLTAPGTAYLAYGGSYSGGIVSFLRKLYPDIYWGAISSSGVTEALYDYWQYYEPVRQYGPPKCIANQVKLINILDNILEKNNATTVAQLKRGFGMQGLTHSDDLANLASGGIGWWQSRNWDPAVNSPQFSYYCGNITSNSLLWPKYASMKANATALISAGGWGNESAQLLNPFLNWLAWTNDSYVGSCDATLDECYNNHNASAPMYTLKNTTNYNSLSWAYQYCTEWGYIQDGASVPKDRLPLISRLLTVKYLTNVCRLAFNITSPPNVNAINKYGGFNISYPRLATVGGEADPWRPVTTLATLPEPDVLNKTSTASEPVILIPGAVHHWDENGLFPNETTADLPPAAVVSAQRAIVQAAQGWMAEWNATMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVS8</accession>
    <name>A0A1C1CVS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBA/TS-N domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVS8"/>
    <dbReference type="STRING" id="86049.A0A1C1CVS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09559"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04043"/>
    <dbReference type="eggNOG" id="KOG0431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000354">
        <property type="entry name" value="UBA domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="237"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="759"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="929" mass="100444" checksum="79B4932998629775" modified="2016-11-02" version="1">MDDIAGLNWNSTPGNGQKPATLTSTSTSNYSAFNTLKPTPPASGRASPLNPASTQGPSKPSTPANDSFANLISFGTTSNKNLSLLEQQKRQAEAKLHEQKAQHQDLTAQYAGGDEQFWNNLGSGRGSPAISNTKTQTTRTRNNALDDDDDDLFAAFNKPPPAKNGGNPASVERNATKNDDDDPFGLAEAGPRRADTAATTTTVDDDDVLGLLGKPVSARQRHESPPPATRNDPTSLHPQDQAVAELVDMGFPPEKAKVALEATESGLDVQAAVGILLNQAHAEARHKTQSRNGQRQGADEWAEGQQSRVTARRDDSETSRKRPQGAARAQDKDIEKMAAEFGTNFLKTANSLWKQGTKQIQKAVQEFNSDTEAAAAQPKWMRETAERPARKEHQPRQQEIETTSTQRKRSLEAQAQSDLTNEAMMLEGSRPAPPSRPSASSQRPGSFIPGGDSSRDRSPAMPSRLRESLPQTQPVFLRQQNQSPAAGLKASLNRAAAEEQAAQAYVSSARRRKPQSQPPASTPPVSTAQTDLLEGSFKDSTPKPSRQAAPSIAGRPHPPRPQTHTPASASTPPIQVRPPPPTRQVPSVSAIALKASHTAREKGNDHFKRGDYASAHQAYATSLSHLPDSHPLTIILLTNRALTALKTGEPKSAILDADKAIGIIGPSKGENETVDTGDDTSKPMREYYGKALMRKAEALEQMEKWADAALVWREAVEGGHGGATSIQGRMRAEKAANPQASRPKPATPQVRKTASAPPASQRNAAASVSASAKPAEAVSRLRAANALAERQDDEKFRLSDAIDARINSWKGGKQDNLRALLGSLDQVLWEGSGWKKISMADLVLPGKVKIQYMKGIGRVHPDKVRLKSFATWIDGDGRNPRFRRCVHTRLTIQRYQIPTDATTEQRMIAGAVFSTLNEAWDKFKAQNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CW42</accession>
    <name>A0A1C1CW42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative HC-toxin efflux carrier TOXA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TOXA</name>
        <name evidence="9" type="ORF">CLCR_09865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CW42"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09865"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04102"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="90"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT52752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="588" mass="62321" checksum="53A67BBF4B7ADE2A" modified="2016-11-02" version="1">MATALSSNPSASTSSSELSKPPLPEDAYEKQQSGVDVPTRQISGSGRSVPAEKDVLDAEQDVHIDGADLGRKISRIDTSDYPSAFPLAMIVVALACSIFLVALDMTIVATAIPRITDQFHSLDQVGWYGSGFFLTIGSFQATWGKLYKYFPLKISFLTSIFIFELGSLICAVANNSTTLIVGRAIAGMGGAGIASGSYTIIAFSAPPARRPAFTGIMGATFGVASVIGPLLGGVFTDHLSWRWCFYINLPIGGVAGVIIFLFFRTPKAAKPQQASMREKLLQMDFPGTFTLMAAIVCYLLAMQWGGATKPWSDGSVIAVLVLFGVLILVFIAIEFVSGDRALLQPRLLKDRTIGVMSAYIFTVAGAFFILLYYLPIYFQVTKGISASKSGIDNLPLVLGASIFTVASGGLLTVWGHYVPLMALGSILASVGAGLIYTLEIESGSDKWIGYQALVGIGLGLIFQIPVIVSQAIVKPSDLSSVSAIILFFQTIGGAVFISAAQAGFANKLLHQLPSKAPTVDAGKVLATGATDLRTVFTPAQIPGILDAYMEGLRVPFIIAITCACLTFLIAFAPRWESIKGKVKLDAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWU7</accession>
    <name>A0A1C1CWU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIP41-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tiprl</name>
        <name evidence="3" type="ORF">CLCR_10672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWU7"/>
    <dbReference type="STRING" id="86049.A0A1C1CWU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10672"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04372"/>
    <dbReference type="eggNOG" id="KOG3224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT53033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="276" mass="31470" checksum="91AD90BD9BC58664" modified="2016-11-02" version="1">MAVNGHRAPNGINTTFPSPSAAPPRAFSIEGFRVQTQKLPILKAGPIEEMTKKLGIAPPEMIFGDNLVTIEHSASQWGIKFDAFGALDRVDKTGERRLKVAYSQEWQQSREDQHDIKEVVKPFDWSYTTDYKGDLAPGSREFQPSEVPIPLELLKRPDPILFFDDVVLYEDELADNGITMLSCKIRVMPARLLLLCRFFMRLDNVLVRLRDTRVYVDFGKKEIIREYVAREEGYSKVCDRLASRRDDVTAVLRDPNQMADILPVVEKTLERVELGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWW9</accession>
    <name>A0A1C1CWW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWW9"/>
    <dbReference type="STRING" id="86049.A0A1C1CWW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10894"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04288"/>
    <dbReference type="eggNOG" id="ENOG502QUEK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2595934at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19861" checksum="19DBB75FEFD89674" modified="2016-11-02" version="1">MGFSFAQLLAYDQSLKTRSARVRESLLSEMVRLSAAIISLAMTTTDDRTKHLSDHIYHMITFAAVTLCRLLHMYDEQLARSHGIAELDALISKLVSWLKSIGLPCHAAFTLGDIVDAFHKKLRPTARPSPITSEENNAWADSSFWANFPDILGPDPMSTGNWDFIPDWERFNDNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWX9</accession>
    <name>A0A1C1CWX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_10446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWX9"/>
    <dbReference type="STRING" id="86049.A0A1C1CWX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10446"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04359"/>
    <dbReference type="eggNOG" id="ENOG502S2NA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="4">
        <location>
            <begin position="88"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="329" mass="34932" checksum="DD806A407F962B91" modified="2016-11-02" version="1">MDITHIVQPNSTASKTDPADVIMWASSTSSSAAAASQPHPGQGQPTTTSQSSNTPAFPGPLLVVDRDRDRDDNGDRQRTLLPATHTRTALLLIDIQRGLNTSNGYFGSDRATPTLEGNVATLLSRCREFNAHARVAEVNSTTTTTTTTSAYPIQMIHVFHQSSNPASPLHVSGRAQKDGIEFMPCAAPDESSAFETVLGTRANSAFADGRLKRLLAEKRIGQLVVVGIATDHCVSSSVRWAKDLGVVKRDWDRGSHGGGGGGVTSGEAEGEMDNEGTIVVVRDATACFGKGGVGAEMVQRVSLASLEGYGMVLYQWPVGRNEATVKELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX02</accession>
    <name>A0A1C1CX02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="8" type="ORF">CLCR_10263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX02"/>
    <dbReference type="STRING" id="86049.A0A1C1CX02"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10263"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00078"/>
    <dbReference type="eggNOG" id="KOG3046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="433" mass="47107" checksum="08FA93051DE47B6A" modified="2016-11-02" version="1">MAAPRSGAQARNAETTNAPSLGKPDSDQDHDYRPVSPYSYRVGAASGTRAVARAGIKGKRFDNAPDLRVHRHRKTKYSYRIGIRLAREKLLTFPQYNGRVKDSVRQWGGSFVTLKVPPWQLRAIDAIGAAPRNTIVPTAVVSVLGRPVSSLPKVSTARSPFTTTTSAPSRLSVTGASSFSDADLGQPNTPFTTYPSPEAEADPRCIEAKTAAAQQDLLLAQTTGSFSARDTRGRYSAPTAATAATAATFQIGTTFDDLPVAERLIRNNTMAPVKDTSSVHNTIKGIIQHLTDIQLQTHGYIPQTQDLLVDKLTDLTTSLAELKRLTSAQESPNNYIHQVAIAPEIVDYVDDGRNPDIFTRDFVEIVQRGNAVVHGKQRAFRDFTEVYARKLKEGIPGVSAQVDRVLKNAGFEEQDASRSSTNGVHDAERNVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXG9</accession>
    <name>A0A1C1CXG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09762"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00122"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="654" mass="70786" checksum="D5DE49A6F55826C6" modified="2016-11-02" version="1">MSSNFVRMEWPNAHFGFDLDLIRDPPYSPGQVPLTNSLPSIDESLLTTPLLDSWTCRETHQDNSAHDIDECLITTPLLDFWPCRETHQDNSAHDISMPLVFSVETDEQEESKGVSQAQKHRSRTQDLTPVSKEGKKIIPASSRHNSGGTKVVRTAPAGYLFYCPSSKCNRSYSGKGYHRRGDYANHVLSHHPELPHPDSLASLKEIPRHGPELQDQRQRPWGHCIDMERPSPEVTTPSGPLLSGSGGLVECSSSSSIPSLTYSASTSSMAQSNRRVRGPYSKKRAFGPQVGSCRHFKKRGTSCSSHSDNEEPEQDAIGAANLRYVAQASGSRSEPVNGEIILVDEGIHDPETTTVQNVLTGAASSPLPSSHQHFPPAAQFAITDPAALSRLHDDQRSADLSFKPRTGEPVDDSRLRFGLCKRASLETHYSASPAKEHENQAELSATGSEDVDEDDGSEELSIEEVVAACFGSESARFAVSAFEKIASDGFSSLSGVGDVSRYCLSGTNSSPSSSTEAHLPTPAKTSSSPGSDKRKTPPGGGGGNQGEDQNGKGGGDGGRPFKRPKGDPKAQAQANLRWDCPFGRTPSGVAGSSAGCAETGLQLNDLWYVIIYGRQTALMRVPQDTSKTGSLRLFRLWAEILWRARCFTSLSRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXU5</accession>
    <name>A0A1C1CXU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Viral A-type inclusion protein repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_09424</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXU5"/>
    <dbReference type="STRING" id="86049.A0A1C1CXU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09424"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00331"/>
    <dbReference type="eggNOG" id="KOG4674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07926">
        <property type="entry name" value="TPR_MLP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoprotein TPR/MPL1" evidence="7">
        <location>
            <begin position="173"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="NUA/TPR/MLP1-2-like" evidence="8">
        <location>
            <begin position="477"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoprotein TPR/MLP1-2" evidence="6">
        <location>
            <begin position="1059"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="641"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="830"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1482"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1604"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1661"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1792"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="401"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="562"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="902"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="961"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1244"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1306"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1513"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="832"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="862"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1482"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1661"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1676"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1856"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1883"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1938"/>
            <end position="1953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT53364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="2020" mass="226164" checksum="6AAAAD4635A76103" modified="2016-11-02" version="1">MAAEVDVRAVSAFSSLPESSVNSLLTNPTAELVISLLKGIEAKVKEFEQNKSQKVKLEVELETVVRTSESKAKVLQNSRDKALAESSKLRVELQTSGNNICRAATTNESSEINTLKSRISSLEASNRDTLALLESKNTAYESLSQDLSAQYQKAAELRKQVTTLEQSVQSANASLTSAKFKGQSLLQEVELLKKNNDWLENERRIKADEHTNFRKEKNARISELSRSNEQYISELEALRRSESALKQRLEEQITKFEETLEEVQKMREDKISAEDSFRVELESVNRLAELQAASAETAKQRVQELSAALEEAREEAADEIGAIRAEIETEHNDRVAAEERVAELERSLERLQGELEDARARPSTPHRATNGSGITTPLRPGTPSGIFSPASVSRGKSQMTMTQLFSEYKKLESELAGEKRAREQLQENLDAMVDELENSKPEIEELREDHARLQSEVVEMSRIVDKANSDRDAAVKELKQVQGQLKSASREVEVLAQQLRDKGSEIRYLLVEQYVREQGEALTREDFEELERQTQAALSDDMANLSENQQLINQRLVVFKNISELQQQNEDQLKTIRNLISELESNEAKQHEQQNHALNQELEQARAQIASYQDELKSMVAQTKTFIKERDMFRNMLTRRGGHLPGQVQPNDFSRSLPVPSGESPAGSVPGGDADYAKLLRDLQQHFDSYRQEASTDHSALKNQVAELGRKNTQLQTEISRTVGQLTAANQRYEMLQANYNSLKTENGEIQKRSWTAMENATKQELKTQQVAEELVEARNLLDSLRRDSANLKAEKDLWKTVERRLIEDNESLRNERSRLDQLNASLQTMVNEREQTDAETRRRLQSQAESLESELQSTKRKLNEEIEESKKSALRREYEHEQSQKRIDDLVTTLGTTKEELASAKTARDHLQARVDELTVELRSAEERLEVLTKPAEPANGTDGGEETTLSKEQELAVEVSELKRDLELKTSELERANEQVEVYKNISQASEERLQELSETNDQYREETEALIAEKDAKIKDLEQRLEDISAELNSTNQDLSRLRDEQADFGRKLDEQKSGFESEIERLKEEAEKSAEQAQFNLEASKVQAQIATEAQQNYENELLKHAEAAKALHTVRDEANQLKLEVVELRTQTETTKGDLERKQASWDEMKERYETEVSDLKKRREELAHQNNLLHSQLEGVTQQITALQRDRTALAETSNEEFNTQPSAEHDKLQEVITYLRREKDIVDVQYQLSVQEGKRLRQQLDFAQSQLDETRLKLDQQRRAEADAERNALSHNKLMDTLNELNLFRESSVTLRAEAKQASQALAEKSKRVEQLEDEIQSSRARIAELENLLELREGELKLSQEDRDHWQQRTQNILSKYDRVDPAELEALKEKITTLERERDEARSELATAVTERDEARTALQAQIDGAQAAIDTARGDLKTRLETQFKGVIKEKNTALRERKSELDVVVAERDAMQIEIDSLKEQLAAAQAQATSTATTQVNGHPPAEPDAPTTNNATDTDTVELEAKLKELEVSLAEKDKELNELKSTQEEKFMSRVAANEAVLNKRLAEFKQQAQQAKVAALEALKAKLDAEHQQEIEALRVNSVPVATDLQKPSEDATPATAPVTNGEIPDDVLLSLSDEKARMLANQHQTIRRILGNTIKNRIEKEKESMRESIRKELSESQDSQPGGSVPATDSQLDERLNAQKENIVKQKEAEFETEKQALLKQYEENLNRERQSLASKHQEELRTQKLHFDEESAKRIEEQVKNAEQLAEKRGAVKLNMSQSRLAVASAKLEVVKKAAEETPQKPVGEVWEVAKDAKPAAASKPAAPAPPAAPTPAKVTTAPSPTPPKPEAPKAEENAQPQTVAPEQPAAVPATPQQPKPNPFQPSATPATPSQPAQPVQSTVPEAGRQPQQPGAALMNQLQSGLPRGGSVRGRASGIPRGRGGAPRGGRGGGGPNVHTGVPQQAGRGGGGAQSPSRGALNPQAAQFTPGGGNKRAREDGEVAEGGGQGKRIRGEGAAAQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYI1</accession>
    <name>A0A1C1CYI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10337"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00453"/>
    <dbReference type="OrthoDB" id="2522477at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="219" mass="24516" checksum="28AD27C9CBB1DD9D" modified="2016-11-02" version="1">MSKPRTCYFHDFASHAETPRIWQSLPVGDTSTCPETPASKGLACPDRIESRLETDGRRAKWVQNVSIRISTFDVAGAAFELQLISRFPNLKSLTVGDVPSYLEPNQAWTNLKIHFDHASLLEKESFKGAFDLTGLRQLKKLSITAEQECVIDRSDPHRPRDYGVDSAWRPTNLVKRLPARLEHLKVKGYVFRWSVDLAGLVDDLFGTAGTVGTQAHHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYS5</accession>
    <name>A0A1C1CYS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYS5"/>
    <dbReference type="STRING" id="86049.A0A1C1CYS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09512"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00577"/>
    <dbReference type="eggNOG" id="ENOG502S1K8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5389734at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="842"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="881"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="945"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="978"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1029" mass="110243" checksum="C51E57215430E16A" modified="2016-11-02" version="1">MSIDKISNGGQAIVRPPSHPVPQLQLPFEESMMESMNDEVADDIPTDAMVRRSMLLEAPTYQRVIAGRWKQKPGEKYHPLWKLVAQLTFGMHLLSQNMAISEEEVMRILQSHVDDIDAFLERTTEDFDLAQSDIHERIRCLKLPLAHGDVFDRMLEDRAFRASILEGNEKIDHVVNRTKRAAKDALKDVQKGFDATNVMDKYLSNLNSTWKRNSPEHEAVLVAMLGNVEGWRRAFLELHLQGNKLAGSLKKLAEVVSEMQLRAATVSRNLVARAQKTRHITSQAGRAPSALGPIAEQKPLPTEPGRRHSTRNSSRSTQLTSYSSRPNSGQKSSHGMISQTQSMGQHSPQSSDSRRPEYTARSLSSGSAAFDSAQHASERMLSIGGLLLRPNEEQLIELPADVPEDALRQAPVSIKNRLSMTLGLRSRDTASHRISSVYYPQALSNLLKSPGISSLLLTPEAGIKGTPVQALVSPIMSEGEAGFFLAQGQSPSIGFVTPESRTGLNSTKDSPSPSRTSARASVHEASTPATRRSSIRGPAFTSHPAVMAMAAPPVELPAPVTDANRPTAQEKRPSSSSSRKGSQSQLSSLGEPGPEFAEAGTSISASVPEPRILVDTSVVTVSVDPASATEETSAAAHQKVERPESRDVNEQSTLNQADSQAQQKTATGPLHQQETIATPSAGKELAKAEIDANPERRLEAQTMVNGNLNPTTEPESAPNGPATERSPSTDTSTKFVAELEAFVPKPPDVKPKEDDGPVELEAPHQTFKLPPRPVAANEITEKGAPLASITQLDGSLKRPTNITTKPCMKPKDFGGSNTAEPIRPLKLKLAKKDGKIVPVQVGSPSGTPTSATSSPKLKLKVDPVAEIIENISWTPTSPIHSRAASSASSNSAQRWSHRSSRSLGPPAQAPAPPAPGGRPMVEPDFATAGQFEGERKQKKKKKDSSSSAGSKSGWKAFFRHSSANNSGSTGALDGGEGSSTTAATATQAPTSVSAPASERAPSPAADMMTTSGKDVLWFRGNGKKTLSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYX4</accession>
    <name>A0A1C1CYX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11018"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="125" mass="14239" checksum="89DF69CD3756DF88" modified="2016-11-02" version="1">MEACTSCVHHWTLAALSQVDDEKKYWYALDYVGEHRLTKKGLNSLGHVRLADLTPHTLWLGHINPCHGDVTRGSRRRPTDRVKRPSLLNSLIQQVQLVAAQQINILTLAGVRERRCELITSRHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZF3</accession>
    <name>A0A1C1CZF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10988"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="99" mass="11068" checksum="27CE42BF7930B304" modified="2016-11-02" version="1">MFALLIQPPVSAHLAVGVSDKFIGGRELRMLAWLLHIISSMLRDSLVQIHPNLKRQYILVMSRLQSLPPSNNVRLLLNLTDDVNGSRTELDALSSPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZI7</accession>
    <name>A0A1C1CZI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">3-dehydroquinate dehydratase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_09678</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZI7"/>
    <dbReference type="STRING" id="86049.A0A1C1CZI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09678"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00862"/>
    <dbReference type="eggNOG" id="ENOG502SK48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2563500at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="588"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT53954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="702" mass="79376" checksum="57B34A0820296A2A" modified="2016-11-02" version="1">MAPTSRKSKTTCMQCRARKPRESGTTGDTVSSDQPLVQLERRRGVRACTECRSQKIKCGGETPACANCLRRNRPCVYPVLKRPHRTPHASNLPSPSTSQRSDPQQQFLSPSAQPAAELEQSLLSSDGALPGRDEVTSLIEAYFEHIYALPWYAFLHERSVMQRYREGQIEECLTLAICAVTVQRLHIEPYARGLGAKWAQKSEDILLQYLESPSTSRLQALILIVRYRVEVGHFSRAFMLAALAGRSAVALRLNYERPELRFLAQEVRRRLMWSCFALDGNFSVGLREFETCPPEHVYLQLPCPETAFEEDAPVATAPLRATSFDKPERMGTYAACIRLAAIRTDIMRLTRRLAASFVPPDELMHIVRRFEDELQHLYRSLADSDRYNPKIFSYCARPARILMVHECWHQAYTDLYRIFLTGYREAAPPSAMEGIPREEILRRRTLCLNHALSIVQIFAAFSEQCNVQTIDFDTAICAYHSARIILFNAQTDVVTQSLSMPAALEKAAFCQSIMNRYFRDSPVVEPMKRELELLIARHSSESSANPGIQVPPPEEVLEGHLSRLADEARTRQRLAIHSLIGRADFVDDSNEVTSPAPPGEYPSATVNAGARPQRQRSIRNNPNVKVAPQVLRSHSLLGAAHAAQPKQANQGVEPVINEPTNYAQEDQNQWLDGMRLAFNPWMGWPETLETYGFTQDLDDDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZZ0</accession>
    <name>A0A1C1CZZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZZ0"/>
    <dbReference type="STRING" id="86049.A0A1C1CZZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10003"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00976"/>
    <dbReference type="eggNOG" id="ENOG502QQW9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="164921at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019431">
        <property type="entry name" value="DUF2417"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10329">
        <property type="entry name" value="DUF2417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="537" mass="60161" checksum="4C7E549B2D4B821B" modified="2016-11-02" version="1">MVSLWGSKNKDDDRPTQDGEEDNPEATTSQPQSNRRSEEANERTRLLPRNDRAQGYLSPDDPAVSPYNLWSVRALRWFEVLFLLITCLWWVLLFISIFVSPPYFNSRGSGFFDVAYTTLTIGNILTALLFFATPSTAMSVLSMATSVLLLIDMIIILAVPRIRVEEGWIGIASVIWAALIGLYNVVTNKTVKWGKAEEEERLTGRQETRRSLREWCAVFTATFLMSVYVIIVVLLTAVLVLRSRDATLPAPGTRYLVDNDQYAIHLACVGNQTYYPDGKPKPTVLLEGGYMPVEDSFEGWVYDAWANKTIDRYCYWDRPGIAWSDNAPSPHSAGMSADAISEALAIAGEDGPWILVSAGVGSIYSRVFSARHPRDIRGMMFIDGLHEDLLYKIANPGRGFILWGRGIISPLGLDRLAGALFKGRTKEDRVYGKSSYQGGKFIKNKLQENLVANSLTKNEVVTARNIQAPKVPLVVVTSGVHLQKDKDWERKQEDLTKVTEKLIAWDIVKGAPSEEIWRSAQGRKVLEKRLGELYKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D092</accession>
    <name>A0A1C1D092_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CLCR_00240</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D092"/>
    <dbReference type="STRING" id="86049.A0A1C1D092"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00240"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09421"/>
    <dbReference type="eggNOG" id="ENOG502QQ71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000152">
        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651178" description="chitinase" evidence="17">
        <location>
            <begin position="25"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="18">
        <location>
            <begin position="26"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="409"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="506"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="572"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="419"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="572"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCT54177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="659" mass="66015" checksum="2BB806895E8A3593" modified="2016-11-02" version="1">MHTPVTSSVLAALTLSSLLVPTTAQTYSSCNPLQQSGCPADPALGRSVDVEFAAGASDEFTASGAVSYTSDGAAFTISQRGDAPTLSSNWYIMFGHVDFVVKAAPGTGIVSAAILQSDCLDEIDWEWLGGDNSQAQSNYFGKGITTTGYNRGAYHGAPNNHDEFHTYSIDWTADQIVWSIDGQTVRAMTQSQAEAGQYPQTPMYVKLGAWAGGDPSNPEGTIQWAGGVTDYSAGPFTMYVKSIHVRDYSTGSQYSYSGTSGTWQSISSNGGQINGQGNGVPVSSGSVPAVTSSVPNSAPLAFGNGDDGSSATATRTGWPWSGTATATVASVFGSSSPSPSPSSLAVLSSASVSASTSLDVFTSYDSQGSPTLVTIYPATSATPACYDDHGLPTTCATVIVPLSNEPASTQSSAQTILTSSGSPNSGTVASSSSVAGPSGNPSTISASSGATPGSTAATISGSPSTDAQSTAAAASTGTATTITSPYVSSLSSVNSLSTDSSSQTAATATADLTSNVSSNPTSQPEATSSTSSSSATEVAQSDSSTSPSTPSQTVITSNGSILTVILTSSTSLTSNSLSPTNSGLSTTSSTTRPSTTFSTSSQTPSRSSTASSSSSSSSSSATTTAPSETPPAPNNAARPTSCLARGVILMVMMGTLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D095</accession>
    <name>A0A1C1D095_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_00157</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D095"/>
    <dbReference type="STRING" id="86049.A0A1C1D095"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00157"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02532"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="44"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="527"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="625"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="724"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="817"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="906"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="545"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="912"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT54162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="934" mass="103342" checksum="0C5EF83B2C454CAF" modified="2016-11-02" version="1">MDSLHPDSAAAMTAHRREAVRLAQQQQQAVVEMCKRSKQPEPDYGFDELIGKGSFGRVYKGRQLSTAKVVAIKVLDIDEADFHAFGDSKDEQIRDFNREIRILRQAQESGAQNLNRMIEALPVHSQLWMVCEYCPGGSVKTLMRATEDKLSEKYITIVARELAKALKGLHEAGIIHRDVKAANVLIHQEGRLELCDFGVASILDTQTDKRKTFIGTLHWMPPELWTDNPEYSDEVDVWEYGCTIYECAMGKPPNADLRERQQLKMRMRRMKQALSLPDSGEFSDGLRSLVSYTLTPDASTRPSMKDVLEHEFLRDTEETHPTSMLTELVETYYAWLFQGGQRVSLFMPGGAAAAPVPGSDADIDADDEWNFSMTQDFERRVSAILEIPDFTGLGSDEIMEGEETPKGLRRPGELSPPKEMTAAQKANFEARVKRGADLSNLFNQDQPAYEYKTKTDFIPVPEQRRISDLPFRAMAEDRPSSIASVAIDLGDFDEADYAIAAAPPRTEDKIQTVFAGTPMREETIRLADASTLREKRANSKGPRDPNNQSLTARRASSTEELPSSTAQRDFGTSQEDWTVKNRTKAPELQEPAEITSSRPGHTTMDWSFASAMSEAAVSIPQINVPDEEPKQDAPGPTDEETSAPADPEKKARKHATMEWSFSTAMAEAKATEDEQQTSEASPPSEISHQKPVPASRPTPTRPAPLMRQMTMPVTLQDFTAVEEQEIPRPSTALSEAYSDVSASSTDVDPFGLEREDVDGDHPGPATMDEDVHMGQFYSGRGRTMFSRRSSGVKTPLTANGPGPTPYAMGRPARIGEDGFPGSGHAQPNGLPNAHRASDSSQLSTATAIPVGMRSPVVAWVPPVSPPSMAVMAANASNEDVEAELTRLLESMQGTLNVAREVVGGLERRMDVEEGEEWVSEEEEEEEEEEEEEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0E0</accession>
    <name>A0A1C1D0E0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">sec31</name>
        <name evidence="18" type="ORF">CLCR_00221</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000005">
        <property type="protein sequence ID" value="OCT54214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0E0"/>
    <dbReference type="STRING" id="86049.A0A1C1D0E0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00221"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09459"/>
    <dbReference type="eggNOG" id="KOG0307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000007">
        <property type="entry name" value="Protein transport protein (SEC31), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000193">
        <property type="entry name" value="Protein transport protein SEC31, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="163"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="254"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="471"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="788"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="851"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="883"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="953"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="977"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1030"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1077"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1137"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT54214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1278" mass="137399" checksum="299DD396A6D4D74C" modified="2016-11-02" version="1">MVRLREIPRTATFAWSPDATSAWIATGTKSGAVDVDFSNETCLELWDLALDKPDQGHELAPAVSLPTETGFHDLAWTAGQDGRKRGIIAGAFDNGSLGLWDADKAISEPAEAPIFNNKIHSGAIKALQFNPKIPNFLATGGAKGELFISDLNHLDAPIRLGSTAARADDIDCLDWNKRVSNILVTGSSGGFVTVWDMKTRKESLTLNNFQRKPASAIAWDPEKPTRLITAVPLEQEPVILVWDLRNSNAPEKVLRGHDSGVLSVSWCPQDNELLLSCGKDNRTILWNPQTGQAYGDYPVVTNWTFQTRWNPHNPNLFATASFDGKLQIQTLQNTNPSSTQTDQSQAANEEDFFSKAQTQPQSSSFSLLKAPKWFERPVSASFGFGGRIISVRQADPGKSRASKISISRFEVDSEVGSATETFEKAIQSGDLTSLTEQRIAAAKTDEEKADWNVIKTLVSTNPRAELVKYLGFDDSPEDTANGAEQEGSEDDEQKPSVNGASKSHKRFQSIFASSADGDFLAELAATKGTRTNNPFQIYTGSESPADRKITRALILGQFEKALDVCLAEDRMSDAFMIAICGGEGCIKKAQEAYLAKQSGGSSYLRLLASVVGKNLWDTVHNADLANWKEVMATLCTFADEQEFPDLCEALGDRIEEEIDDLGSITRKDASFCFLAGSKLEKVVKIWIDELKEHEEAGASEADASSAFSLHARGLQDFIEKVTIFRRVVNFKDDELSKAGEWKLEALYNKYLEYADIVAGSGQLDVAQRYLDLLPTSYPGADVARSRIQQSRKKTAAPAVATHSTTTATRNKPLPAMSQFQPPTTAFTPATPPVPTPYGTTPMQPSNPYAPPAASNTPANPYAPPTGGYQPAGYQPPQQMRMTPGPPPPAPYGIPQANPIPPPPRFTQSPAVPPPSQDKNMTSWNDIPEGFVKPPTSRRGTPSVPVQPVHNPFAPSPAPISSPPNAGPPMGARQRASPVPPPPKGVAPPPRVMSPLASGQPPIERPSSSAGNAYAPPSVTSPPVGHGMVSPPIPRGPSPFTAPPSQAPTAPNRYAPAPGSQPATGPTGRPSIAPPPQGSSFQATGPSANPYAPAQPAPSARTTSYGPPQPTQNTPQSATAPPMPTPQQQFISGPPPAGSGQQAPASQPDTAGTNKAAAAPPARKYPKGDRTHIPSSAQPIYTILSSEMSRVEARAPTSFKPQVVDTKKRLDILFDHLNNEDLLKPDTVAQLVELSQALERRDFTRAAEIQMDVHTNKVEECGNWMVGVKRLVGMCRATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0N9</accession>
    <name>A0A1C1D0N9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6314 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0N9"/>
    <dbReference type="STRING" id="86049.A0A1C1D0N9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00958"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01683"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6314" evidence="1">
        <location>
            <begin position="18"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="206" mass="22997" checksum="12DDBF59E4AD00E8" modified="2016-11-02" version="1">MATRPAASALLIRLFEDLAGTWLLNRQLRSADPSEPSGRCAGQALFMKRPSPSPVVDPDGKLHSADAELLYHEHGEFEMMMATGNNLTSVPTFTFSRKYIWRLQTAENGHTISIWFTKPGTETIDYLFHKIDIPFEDDQNLGADGRLVLHGTGGHLCVEDFYSSSYTFTLSRSSADSPIKLASWTTVHEVLGPKKDQHIETTFVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0R4</accession>
    <name>A0A1C1D0R4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ino eighty subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0R4"/>
    <dbReference type="STRING" id="86049.A0A1C1D0R4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00780"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01702"/>
    <dbReference type="eggNOG" id="ENOG502QVDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5413003at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038014">
        <property type="entry name" value="Ies1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287:SF1">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="817" mass="90632" checksum="CF5003F0C30E689C" modified="2016-11-02" version="1">MTSREPSAAPSDGDTIDDQADETKPDLADLDHEQIESVEGAPASSTPTNSRRIGRQKTSSGRKARPRKGAIWIHEQPHEGTEDEGSVVSATHSRTKKSEATPESDLRTIGTAVGTRRQANGTVGSVYSGSKVRHIKKPDGTPLWRKEIQFEFLQLVIEDTQPVFTRISDGKTGCCFSDIYVDCMARSSKTSKILKDRLQFDRQAAHNMAMICLLVNVGRMNTTLNFFPEMRAQLRTYHSIPSLQAYKSQRDYKSLQDAPRLKSILKGASEDTIEPRSIQELKAKQVPRTNPVNLIFVLSQVAPRISETHFTDKVDFFDLAMRPTISSASRARAFLWLMWWYLESNFTKEDALRNPYGPGEYRDDEDPDDPDTVPQLVPKLVMITEEEGDAENVDPPEEIAFAEKMTQERKRIMAENANDPPLVMADPGNPDHKALKRLKRGAAYGDEDSLISDVDSRASPGVGRSPAPEALNAHGHVMASALGGQADSLDDDWEAVDPHPGRGRYKRVRGKNTPTRVRGIPRQSDGPRSVFKAGRNAGTPDTVDRYRATPQPLQPGGANHPVIGQLGTPRGKNEIDTLRAEPGGGTAGTKARARTGYQRELEEHRQRRVEWALRRRRRHALKEARQIRQGGRWLFKAARRISELPPTYDSEEEEEGGGSGFGGLLGRRWFGDTNVDSEAKSLPAGYEPDDYGEEVESWAGLLRRTGRRLEVWSGDRDLGVYHARLHRHHAAPNNFAAAPAQPVTNGTGKKRRTHESSAHPSAPDTGRTLKSARSAGRDLNDEITQDLLAERSDDDMDDDDSDANGDVDGEESDVDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D0S8</accession>
    <name>A0A1C1D0S8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D0S8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00927"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01610"/>
    <dbReference type="OrthoDB" id="4150370at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="105"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT54334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="268" mass="30845" checksum="7B47D9E3C430A21D" modified="2016-11-02" version="1">MAGRWSSASTSTSLRTWPLASDQPAASTSTTSPLTLASWTGGLPTTLTQHPPTAAEIARYPEYTIYPFQRSPQIASDVPPPADPYDPFFIPQSILFDGPVSPQPTSKILQLPPEILTLILEKVKIPYFQVSLALTCKTMARIASQKNVMSPWRGYRDKDGLFRLLERKNKWMPPSLNLCRACFMFRPRDIAFWEKQLKSPEFDCIYANWYDIFGWFDQTYQQHRCPWCTILGYTAYFREGQFIEDRKNGPRTRTQSMCPDLTRRIDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D176</accession>
    <name>A0A1C1D176_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_02881</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D176"/>
    <dbReference type="STRING" id="86049.A0A1C1D176"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02881"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04721"/>
    <dbReference type="eggNOG" id="ENOG502SQ1T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="521" mass="59255" checksum="42D7A1A35EE49B5C" modified="2016-11-02" version="1">MVGIARARGCGTCRKRKIACGLEKPSCAQCVKSKRICVGYRKYPIFIPHQPPKGDNVESTTQTESDSDGWARSGHPQAGYPDLNSAVTTAVSHGTHIGPTKSLVPLGAQVDANPVLRQQLLKVYLDSHLSKTRVGPMQQRIWLIQIPGLPHITPALEISMMALCLAKLGDLHHDEGLRYESLKLYRRALHVLQLALWDPALMLDDQTLTACVALGMYEMSQCPNRSKHGYVSHTLGCRRLVQLRGPEAHADGLGHAVFVHFRIQEILYSLDQGEYSFLRDPLWQEVPWRKMPRTPYDRIYDFLIRAPELRNRGEMLQFLDPHSKLQLATEMIWKCWKMDSELQSVYDSLEACHQGPVCWPELAREKDLHGDSEDGMLFPVAFQFPNLSIANTVIIYWAVQVILWHGMWQLYRLLDELKLHFTAAAKVGDGHAVSTLFDFPPLEHRADFAAPCRNIFQSVEYALQDSLLDQGPKSVACPLRIAYETLRPYPKFKQEIAWAEHAKAMVESRSLRLLTYYIPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1F1</accession>
    <name>A0A1C1D1F1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">SDH2</name>
        <name evidence="22" type="ORF">CLCR_00902</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1F1"/>
    <dbReference type="SMR" id="A0A1C1D1F1"/>
    <dbReference type="STRING" id="86049.A0A1C1D1F1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00902"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01765"/>
    <dbReference type="eggNOG" id="KOG3049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <keyword evidence="22" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="20">
        <location>
            <begin position="79"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="21">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OCT54508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="298" mass="33673" checksum="CA331029237318CF" modified="2016-11-02" version="1">MAALRTASRLAAPARAAIRPSFAARSYATVTKESSYDLSASRPPINESKTSTVQEPRPDKDAKIKTFHVYRWNPDEPTSKPRMQSYTLDLNKTGPMMLDALIRIKNEVDPTLTFRRSCREGICGSCAMNIDGVNTLACLCRIPTDTSKESRIYPLPHTYVVKDLVPDLTQFYKQYKSIKPFLQRDTKSPDGKENRQSPADRKKLDGLYECILCACCSTSCPSYWWNSDQYLGPAILLQSYRWLADSRDERKAERKEALENSMSLYRCHTILNCSRTCPKGLNPAKAIAEIKKSMAFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1T8</accession>
    <name>A0A1C1D1T8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fizzy-related protein like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Fzr1</name>
        <name evidence="11" type="ORF">CLCR_02856</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1T8"/>
    <dbReference type="STRING" id="86049.A0A1C1D1T8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02856"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04821"/>
    <dbReference type="eggNOG" id="KOG0305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000025">
        <property type="entry name" value="FIZZY-related 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="10">
        <location>
            <begin position="267"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="395"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="437"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="525"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT54722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="583" mass="64541" checksum="F3F83AF0D65E08B5" modified="2016-11-02" version="1">MDNDFSAALAVEASERPQTPTLPTPVGSKTPPTISTKRFAGPEEGMSAAQRAIEALEADALNRRLREIEHAGRQRDRTPGRSPSRKRQRIYGDRFIPNRDGQDLQATYSLLHDDGSPATPSRSKKKTPHGELHFQRTEEANRTYSKVLRNELMGDSVPQDYRSLSPDELFGRRQTPPGQPSLSAMPPASITPTTPHKNMFTYKSPQKVIGSGHPTPSSRNAKHPGIINLNARSDLYSISPINYSSQSILQTPRKQPRPIAKVPYKVLDAPELADDFYLNLVDWGSANILGVGLGSCVYLWNSTTGKVTQLCKLPDNDLVTSVAWIQRGSHLAIGTHKGFVQIYDAEKSRRLRTMTGHSARVGALAWNDHILTSGSRDRLIYHRDVRSPDQYLRRLAGHKQEVCGLRWNTEDGQLASGGNDNKLCVWDKLSETPLYRFSNHVAAVKAIAWSPHQHHLLASGGGTADRSIKFWNTANGSLIKEVDTGSQVCNLAWSKNSDEIVSTHGYSQNQIVVWKYPKMEQVVSLTGHTFRVLYLSTSPDGTTVVTGAGDETLRFWRVFGKKGNEGRNSDGIAGRLGDWGAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D251</accession>
    <name>A0A1C1D251_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_03143</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D251"/>
    <dbReference type="STRING" id="86049.A0A1C1D251"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03143"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05067"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF6">
        <property type="entry name" value="N-SULPHOGLUCOSAMINE SULPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT54973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="195" mass="22050" checksum="3A230F9E917055E3" modified="2016-11-02" version="1">MAENHASKAISAYGANINHTPHLDRLAKEGMLLDHCYVTNSICTPSRAAILTGTYNHVNGVVTLDSQINKNLPNVAKHLRTAAGYDTAMIGKWHLGEGDTCQPSGFDHWTVLPGQGDYWDPTFIDMDGHERVTEGYATDVITDKSLAWLAERPRDKPWFLMCHHKAPHRSWECHDKHKHLYKDKIKVPDTFSDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D260</accession>
    <name>A0A1C1D260_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D260"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03120"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05078"/>
    <dbReference type="OrthoDB" id="4159131at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24550" checksum="0E5BCD74211367E2" modified="2016-11-02" version="1">MPPRGSKSAIPIFVFLGLVLVFLPIAALVCVCLQRCHQRRQLENSRARTAHAVAENMHRWSKFSPIEMGDLQPPPPPPAAVAIKPIRGMSVGKRPTHYMHGALGAHEENEHGNPRGQTAQTPTRVDEPRVEARSPAARSPISGPPPPLHSPRYDLQAALGSEDSPASVRTGGERQASLGDAPRVKSQKVSPQEAALAYHAGERPAMPESEAGYLAHGRQQLPRRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D269</accession>
    <name>A0A1C1D269_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alcohol O-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.84</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alcohol O-acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_02908</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aliphatic alcohol + acetyl-CoA = an acetyl ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:17229"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:47622"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.84" evidence="6"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D269"/>
    <dbReference type="STRING" id="86049.A0A1C1D269"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02908"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04835"/>
    <dbReference type="eggNOG" id="KOG1838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004026">
        <property type="term" value="F:alcohol O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000137">
        <property type="entry name" value="EEB1p Acyl-coenzymeA:ethanol O-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="10">
        <location>
            <begin position="155"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT54738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="464" mass="51993" checksum="7AC35EBA004D8B77" modified="2016-11-02" version="1">MDFIQTFVRQAQDHPFLTTFVGATLLAAVALIPSHALRMVKPRYWHSPKSLVLKTKDGKATSFADLCKTLIPPCRLNPFLFNGHLQTIWTTLTKQSVPVYYKRRIFENEDPVYTGQFSVDFVTAPNDKHDPGLPPRTSYFTEQEFQDIGSLDSKPMVVMLHGLSGGSHELYLRHALAPLVGDGGWEACVVISRGCSGTKITTSVLYNARATWDVKQVVQWLRKTFPNRPLFGMGFSLGANIMTNYLAEEGSECPLKAAIILSNPWDLMAGNLALQRTWFNRNAYSGSMGKSMKKLFEQHVDQISKNPKINVDAVRRIKYLHEFDRYVQGPTWGYPTEGAYYRDASSVDSVMAIRIPFLAIHAEDDPVTASEALPREEVKQTPYGVLCTTPGGGHLSWFELGGRRWFERASTALFQAMATDIDLDSISKTGVSGAQLEGQISRAEREPLKPVFEPMRRKMHIPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D299</accession>
    <name>A0A1C1D299_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D299"/>
    <dbReference type="STRING" id="86049.A0A1C1D299"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03111"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04973"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="188" mass="21082" checksum="5832CFBC093931CD" modified="2016-11-02" version="1">MDVPTLPSKVPGYDLYIDGFQALRRPKILQGANITHVVSVLDWKFANNWAALRGFQHLHIALDDVYDSNILSFFPQSNAFIHEGLKHSRSSKSATSDAASNDANDSGVNPLPGGVLVHWWVTHLFIFSCFRLWRFCLVDWPGAQVNGTLTRVMTNTHLAWDHHTWLSGLVQTVVVPLRGRCSPRPPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2I7</accession>
    <name>A0A1C1D2I7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_03115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2I7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03115"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05077"/>
    <dbReference type="OrthoDB" id="4119414at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT54982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="187" mass="20942" checksum="8B6E92A1AD41A8C3" modified="2016-11-02" version="1">MEHSKAPKTPRTRKRTPHACDECRTKRTKCSGGTRCVSCTKEGIDCIYGDRGIQKRKKHLERNIRRIRLLEEQNLILTNALWKIGLSIDHTSDSSSSNDSITNSGIPRVLDWIPNLSSTSLSRYQTSPQHEDHEAGCPPESSHRAESRMGIRPEDTRESTESTESTESTESKPGGSSVMSIDDMLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D3G6</accession>
    <name>A0A1C1D3G6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D3G6"/>
    <dbReference type="STRING" id="86049.A0A1C1D3G6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03005"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05173"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058268">
        <property type="entry name" value="DUF7962"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25907">
        <property type="entry name" value="DUF7962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7962" evidence="2">
        <location>
            <begin position="103"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT55085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="344" mass="38342" checksum="14A51470C0A206AC" modified="2016-11-02" version="1">MYGPNNGVVLYHYSFSPIARRVLWYLSLRGIDYAEPDVAALGIKYRRIPLMAIGRDVYCDSRIILRKLEALFPNSTLSAPNGEAKAVEKLFEIWNMEAGLFPRASQLIPTSMPLLNDPHFTKDREDYSGRSWSKEQIEANRPEALAAIRSAFNVLETTLLADGRDWVLKTNHPTLADIEGKQEVHCVTINPLMQVPKAIWTFDWLNGLKGALPWELISDKKYPKVFAWIARFNDALKAAKAKAPKPATLKGDVAAERILSAAFVEKDLAVDPADPLGLEPGAEVEVFPIDSGTHHRDQGRLIGLTEDEIVLSIQAQGQELHLHYPRAGFRIRAVAATGRTPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6E0</accession>
    <name>A0A1C1C6E0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_00707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6E0"/>
    <dbReference type="STRING" id="86049.A0A1C1C6E0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00707"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01041"/>
    <dbReference type="OrthoDB" id="5600002at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610:SF12">
        <property type="entry name" value="SEQUENCE-SPECIFIC SINGLE-STRANDED DNA-BINDING PROTEIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610">
        <property type="entry name" value="SINGLE STRANDED DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="214" mass="23570" checksum="F8958281CFB0E0C4" modified="2016-11-02" version="1">MNMAGMNPAAMAAGGPVGGGMIMMNNGSPATQVNVGNSPEQVKAQLNTYIYEYFLKLGHYDIARSLLREKEFELRTKPPVKQSPGRRKDAEVNGVDGDAMDTDPKDDIPDDLPRLMHVGDASTPGVGFLFEWFSIFSDLFTAHRSSKMQGGQGGNMGTAAQYLMQHQNIQRMRENQQSQNLARPGMMAGNRFMPANMRTNMMNGNVSREMASKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6E7</accession>
    <name>A0A1C1C6E7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6E7"/>
    <dbReference type="STRING" id="86049.A0A1C1C6E7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00646"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01050"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650595" description="SET domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="141"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="427" mass="47315" checksum="6AD56C494BA17578" modified="2016-11-02" version="1">MARRLLWTWRYIVALSLSVCVSWGFTTSVAQSTGAAYQVAFDQLLQYGQLELDLHTEDDEGGPVDGSNVKGENSFFPWSYEPICTEHLARIQSKLCVYTDAGFSNGRGISIFTTPQHAETVASLLVSDAEDYQPMINIPTQAWYTETTPSKGIGLFASHDLNPGDLITSYTPVLLAYKENVLSRAERETFLHHAVDRLPSGTAAGYRALATMFHDKAFLMQDVASANSFEMSVGGAAHLAVIPEPSRINHDCAPNAIFVINSTALAHTVRATRPIAKDDEITIAYTNPLDGFLKRRKYLLDSFGFECTCSRCRRGESGDAALAEITALQKSLSRWSDPTSTASIKQAERLIRIHREQGLDGYLDPAYCLAALVYNSVGSERGAKKYTKLCIEAIELRLGPGAEDLPTWREMLEDVKGHWSWMRRKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C779</accession>
    <name>A0A1C1C779_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C779"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06267"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07019"/>
    <dbReference type="eggNOG" id="ENOG502RZUI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5553410at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2470" evidence="1">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="236" mass="26557" checksum="B885A92716891195" modified="2016-11-02" version="1">MATPTPAARGPPDAAAMKNRILTHMNADHQLSLRLYLRHYSHVPSSGTISAKMLDISTEHMLVESSYGRHVIPFEPPMKSLMEARERLVDMHVLCLEKLDVSDVVVKNYVPPDRVWQWMLSGLCLLIFSTFPFRNSLRPESGSVIAKIWSLGGAAPWLARLSHTLSPLVLTTVIVLHAGEAVWFINRRLNRHWVETGTAVWWCWVLDCLLEGGGCLTRFDRVVKRMEAAKKGGGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7A4</accession>
    <name>A0A1C1C7A4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7A4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06413"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="129" mass="13681" checksum="A7DDEB63FD357EB7" modified="2016-11-02" version="1">MGLPAALLENTICSGNRTSSPRAPRNAMRSTKNSLITRADRPALSPIEDKETKIVPEDSALNNVRNCSAGEGDSGDVKSNMKSNMKSNVKSNMKSNVKSNVNTNVNTNVNTNVNTSTKTNASTNANVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7K6</accession>
    <name>A0A1C1C7K6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_06372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7K6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06372"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07125"/>
    <dbReference type="eggNOG" id="ENOG502S23D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5525680at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF3">
        <property type="entry name" value="DUF DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11150)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="41"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="167" mass="18551" checksum="F59B98A0FA0AA270" modified="2016-11-02" version="1">MHGEPAVLSVTRYHPENPIKMFLLQPLYAPLLFPNTTSDARDHCANERTFLSWLRLAIYMAIVAVAILVNFHLKNQPTPLERRLSHPMGIIFWVLSLACLVTGLAIYMRTVTKYAKRRALVQTGMKTQAVFLVVSAAIIAACALFLAAEVQASRQGHAGAFDVTFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C870</accession>
    <name>A0A1C1C870_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin-binding monooxygenase-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C870"/>
    <dbReference type="STRING" id="86049.A0A1C1C870"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05463"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07034"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="178"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="637" mass="69542" checksum="B1BC81D01B5DE0FA" modified="2016-11-02" version="1">MATPKYPTRLTNVLRTLPGALPAQNVPADANLAEIVTRCLQSFETWHPGHFTRDAMWRDSFALSGTMRTFYSGPTIAAAWDHLARHHSPCEPRMVKDSCTVAHAGSDSSWIEARFSFRTNGPLPAVCSGFLSLAYENDGSYKIWVLRTILEGFVGYPSVDTMAREKTLGLQQSTKTDYQCLVIGGGAAGLSTAGRLKALGVDYLILEKLADVGGSWACRYNAAKLHGTRHTAHLPFERTFDDEYSLYPTKDEVAKGCRNIWLSTLIKDGYWDAEKRQWTLHVRRNGNDISLTAKHIVLAVGGGGHIPYMPAFPGRESYKGDVVHSSAFKDGSPWKGKRGIVIGAANTGHDIAEDLLEHGLSVTMVQRGATSNSARAADPDMVPLDYLAPVLDAVYNADFDVELADRIHYSSPAAMTRERSNLLIHSLVKANAERFDALERQGFKLMRFGDFFHHQTERQGGHYVDIGASAKIADGRIKVKSDASIDSFTPEGLHFSDGTEIKADVVVFATGFHGNMRQFVADLLGDDIASGIEDYWGLNAEGELEGAFKPTGHAGLWYMGGGCGHARYFSRFVALQIKADVEGKPLKIYKDTPSVVDGPAAPPPDQVAQIEPAGFSVDNLAVAPGGLAVQQQEWIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8K1</accession>
    <name>A0A1C1C8K1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8K1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05883"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07465"/>
    <dbReference type="eggNOG" id="ENOG502RPUR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4176762at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="51190" checksum="C093CEE908807160" modified="2016-11-02" version="1">MPVFERMRRKLSRAKSAPDTLEDGDADDGHVQLQQWPSNALFLTPSDEQLVSKLAFTPETAIIERAPRHYAPSSIATRSSERTVFNNVESGFLSLPTEMLMTLQPYLTPSSEVALRHSCSRFFHLYRMPSFVLTGSELFDFLCMTERDQDPTELDRLVCSKCQTLHNRSSFPSSEIKQESRSRDCRQVWLCPHRYLGYQKTTRTIKAGVEAPFRVETLEPCSRCRNSIRNRSVADRPEKGTSATDLESPKAESLLISKIGILQAPSPLYNTRTTGGSGMYKEVFQVKGVSTALQAIDFRLCPHLKLGDPYILSKFCRACINTQRLPPSVKGPPCINEAKRDFGVKGAGAKCKGSCFTRGCKTQFMFQARESLSPDASGRRQVWLIIVVYRWLGPLLSDGRDSTWTNHAIDHQERKDMRLKWAEWERATRAGRQCMPNWDICLLHPEDSNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8L3</accession>
    <name>A0A1C1C8L3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">upp</name>
        <name evidence="11" type="ORF">CLCR_06228</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8L3"/>
    <dbReference type="STRING" id="86049.A0A1C1C8L3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06228"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07537"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000049">
        <property type="entry name" value="Putative uracil phosphoribosyltransferase urg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF4">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="12"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT44865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="222" mass="23913" checksum="FF30422EC8A30E58" modified="2016-11-02" version="1">MASSLPSNVHISKHPCLRAKLSQLRSKSRNARETKTLVHEISLLLGSEALAKLDIESTGTDVTPIDFEYPYESIDCSKVTIVPILRSGLAMVEGVQTLLPDPVSVHHLGLFREKMTLQPVEYYNNLPQSPEQVAKLAIIVDPVCATGATACAAIQSLRDWGVEKIIFLCVLGAAPGLARAAEEWPEGTQVWAGGVDDGLTDKGMIKPGLGDIGDRLFLTLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8V6</accession>
    <name>A0A1C1C8V6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Ras-related protein Rab7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_06253</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8V6"/>
    <dbReference type="STRING" id="86049.A0A1C1C8V6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06253"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07596"/>
    <dbReference type="eggNOG" id="KOG0394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="205" mass="23108" checksum="7F107382FAD509AF" modified="2016-11-02" version="1">MASRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSTSYKATIGADFLTKEVTVDDRIVTLQLWDTAGQERFQSLGVAFYRGADCCVLVYDVNSTKSFETLDSWRDEFLIQASPRDPESFPFVVLGNKIDMGEDRRMVSQKRAQQYCQSRGQMPYFETSAKESINVEQAFEVIARNALAQEESEEYGGDFSDPININLDQERDGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C917</accession>
    <name>A0A1C1C917_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heme-binding peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_06178</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C917"/>
    <dbReference type="STRING" id="86049.A0A1C1C917"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06178"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07649"/>
    <dbReference type="eggNOG" id="ENOG502S3FB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="652091at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="284" mass="32351" checksum="745D7E48B9F88BB5" modified="2016-11-02" version="1">MTSQACQGDSAQPSLPEQLRTGTRQKHHALNTLVMANLPLCLPPHAARPLHYAKGMILYGQIYSAFEDFMAVQLACSRANQRLAWMYQSMYLPQLLRKSRLQSDIEVLKSRLGRSETEELESLAQKAEVFYQRVKSSLLRRPHVLLAYTWTMYLALFNGGRWIRSRLISAGVEFWLGEALPLSFWEFPDHVHANVEGEQLKEQFKIGFSAAASHLTDDERQDVVEETSQLFDLCSEMVGFLDRNVRTEPLQEVSAGSSPYATPLVAKRSLECIRCRQTCGERPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C976</accession>
    <name>A0A1C1C976_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C976"/>
    <dbReference type="STRING" id="86049.A0A1C1C976"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06083"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07674"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2962696at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="306" mass="32233" checksum="F96E09A9499343A5" modified="2016-11-02" version="1">MSAADTAPIQAANLFNVNGLVAVVTGAGSGLGRMMARALAANGASKVFIIGRRESNLKETADSVPGGTIIPLVGDVTSKPSLQQCFEKVKAQVDHIDVLIANSGISGPPVPTLDKDQKPVSIEELAQNMWKPEPEEVNSTYAVNLTGIHFTVAAFLPLLDAANKKRPAPNQDNFTPRPQIITTASIGGYNRKALGNFSYGPSKAAAVHLTKQLTTALVPYDIRANVIAPGLYYSEMTHGMYAAQGKTEIHNIEGAFGKDVVPATRTGDEQDMAGVILWLCSRAGAYINGCVVVTDGGRLGVVPSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9I9</accession>
    <name>A0A1C1C9I9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9I9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05442"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07801"/>
    <dbReference type="eggNOG" id="ENOG502QR2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5598028at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="489"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="897" mass="96872" checksum="1A60827AC49AA783" modified="2016-11-02" version="1">MAPPPLKRQKTNPAEESRPQPTPQEQAQQAANVPLPPDTPPVPTSTVREEKRSSWLARTWPRKAPPLTQTHRESVSSASSNSPSTIKPAGQESLSPTRKRTKTQRSPSLAMTLGKSTSNRSLPINATTTIVNATSGAAATPGRAHPQSGLSSQAKDDATVGKQAGKDGQRPEKTDDTSTHPLPGEIPTPEPSQPDTAHQIFPESQSMWLSWLPGKKDGVAVKPTEAQGPPLQLKPAEASEVPSGNDPASDPAAPQPEMAEQPQPSSVSATNKRSWYQMWSSSDPPAEVPKQQEPASKPGQSSSTGPVETAKAATGPTKHLDILPPSTPKAKDGSQASSLETSPPPPLHGDGSKSGWVFWSREKKRPESIKSEGEPRVGEIAISDTPSQARPKRASISLQDEAAKPALKPSPQETQSKKAASPKTTEPKQQGPTEQPILAKAQKTLASKQDPSRTTKASSSTAAAIAKEPRPASPAPSLDKRKEDNNLLLPLLHDTITHEEQPSLLQQLARLLYYTREPNAHQHLSLIRDPPRIKHALAIGVHGYFPAPMVRSILGQPTGTSIKFAEKAAQNIRRYTASQGYECEVKTAALEGEGRIAERVELLWKLLLNWIDEIRRSDFILIAAHSQGVPVAIMLVAKLIHFGCLSPAARIGVCAMAGVNIGPFQDYKSPWITGSAGELFEFTNPNSKVSTDYLAAISDCLQHGVKVTFVGSIDDQLVSMESSVFAPLTHPHIYRAVSIDSRIHAPNFLSNLVGFVLKLRNVGVPDHGLIRELSTPLAGSLYTGEGHSRLYEDDAVYALAIAFTLETTSLPNTPITSSKRAPISVPSDGKSTPAGSQTSNPYILPFAMRGILEEDIVKKDLREEAKRLLEQFDQWEPKTKVLKDVKFRLEGVRSQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9M4</accession>
    <name>A0A1C1C9M4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9M4"/>
    <dbReference type="STRING" id="86049.A0A1C1C9M4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05526"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07821"/>
    <dbReference type="eggNOG" id="ENOG502S16F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF3">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="367"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="757" mass="85090" checksum="589B0EB20EB5FAE4" modified="2016-11-02" version="1">MDHVLSKEELEEFHHHIPEIPWLGYDHRPSEVGDFDDYALQRGWSRERLFDLKEGRLGDLEKEGLKAFLQSWFSIGLYEMALSRSLDKDGFIVQRDSSLFFTSEPLRQLFKDLREHFQRLPRDDPHKIQVLEHLVRVLTSASVWSRMLGEPQLFINVNPDFCDETYESIMRLFTLSGVAVQYMGEVLASLVQGSFRGRLQSPWIPIDAYQRSLAERLVKRGWCPYVKTMLSPVNIIVAEYAAIVGPPATRFMHNSCSADGCVRHIIDESTYKPRHIRSGCQCPFVRPSFPRIAEVLDSGRIPLMGFDSISEAEDGMTVEVVPMEDASVFSAVSHVWSGGLGSTSEEGLPACAVDFLASYAEVAGPSKLTWIDSLCIPREKRLRKMSITGMNKVYTRASRTLVLDPELMHAATANARRLLLWVTTAAWMQRMWTLPEGRLSQVPVFAFNDRVVMLSDLMKDADQNDSANPVSGSLMPDLLGLFSANINPLRYIHQSLCYRTTSKREDEVPALAALFDIDPRRILDTKSLDDRMAMFWIGLREKVRIPMNILLLGGEKLPIAGLRWAPRSLLNAGRQLSLLGPPSGVTTYDVELSDSGTLTATYVVIRLQKRSKLLLNKFNPIKLAFNPDPGSREVPVGLFTILVMPKTRTDTEDAGILEDIDAFAVNVTNLEARAGRALANELLSSVKTVVALTMESSPPRPWEEESGANPGRPKDEPCNYARTHSFIARYRMQLSPIETRGDELITGFVGWARISIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9P9</accession>
    <name>A0A1C1C9P9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9P9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06470"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="99" mass="11396" checksum="924603820242860E" modified="2016-11-02" version="1">MANRAEQRTHEQRWRRRFRGSRRPSQRVQIDVNVSVTLLGNAEQHSGRATPEGGEETHTARPKVEARAQNEARNQESSSKLVVPRSSRVEPCDVRVRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA24</accession>
    <name>A0A1C1CA24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA24"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06333"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07973"/>
    <dbReference type="eggNOG" id="ENOG502TGWF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4160385at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="198" mass="21741" checksum="27A1EB70CB0F82A2" modified="2016-11-02" version="1">MPSTCRAKPALFRGLKPVFITPQQASATQKIISSACSRSCIYCDIWKLAALIASHSPLSARYNLSTGTPTNSPMSSAASSPVSTSPISQSPTPYGSIIKASKRIEAYFQTQRSQLNSILSICAVAGADAEEGLRMAHDRCASAVEDLLDQEEDLEEELLKDLEDQHYGCYQYDYSSQYSYPTASYSHERRPSMVRVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAW5</accession>
    <name>A0A1C1CAW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_01564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01564"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03563"/>
    <dbReference type="OrthoDB" id="4158939at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="46885" checksum="5771725EDCBD4E7D" modified="2016-11-02" version="1">MTDPFSVASGAIGVVSLGLTVCDGLISYFSAFKGQDQFLSSLSERAEHLNKSLHLLNQALPPLRTRTPDVARQIGKSLAECGSGILALQTKVAAFQRVHGPSLRRDSLHHAARKAIFPFKKDALVELLGTIDSLQQNLETVLAIANLEATSVQLNIQNVVNDKVNAVITLSNGIRAGVQNVSQDISLLRNDFSAFKSDLGMVKSALDPGLQAVIQRIDHLSGQVAMMQVSHATSRANFQSVARSLQQQLIAKPSLFHQFCVEAKETKITTKPRLPFQETFSSICTCHYSARRQKAQKQVLSFEYSRYTAHEPHCPFHVEDIKQRRLQFKFSCCSMLISRSLRVMAGLTSGAGGYSLSAQVAWIPMVSYYSSLAFRLIYRLKIDLLSTTNACAVLETDRLDLLKLVAKGKAHPRETDELWGTLLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAW8</accession>
    <name>A0A1C1CAW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01465"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03518"/>
    <dbReference type="OrthoDB" id="4156747at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="616" mass="69267" checksum="CC3BE1801FCD7890" modified="2016-11-02" version="1">MQTTLDSASGGDQEQGGTAESPNSTMNHNKNPPPLMFIVGDGKNPQKSTRAIKSAKTSHISSRYRYWSKANHRDLALDSTTKAILNGASSYLNKLSTGNYRKKPPEVLNRDHAEDDDQPLREQSRPLACEAAVIRPKPPTPHVAVRPWEQARKDYEEWAARPLSILGSQFFDIFTPSTAMKYDIEIKTNLYFYFKIIRPFATHLLQSWQWFDNLAQIQASPCLTYAVATFASVFLSGMLRGGRGVVLPPETEKGQNCPWTIPPWLRLHTKCLSELNAILSDPAQVIDESCYQAILFLYRLSVLLADGETGRMHLQALKRMALLLDIDQSSLGRELAVSKINIIGAFLHSKSVVLVRKVKDKANEPETEVVEIDRKFWRSDREWYSHRAGLAGRTLAWRAESPSSSLLPESAAAIARVDPDSKLLGEAEHLEIQRCYQIALFFWKYLNCISFNTSALIVRSNLLELQYRLSNMDLPTMSLICYTTLFNILLAGSEAARSKPERAWFIQQIVWLYPDIQHLDAVWQLLAEFFDPLAVNFKFIQEVWEEVVAARGGGGGTTKSANSADRQLVKPIKQFRPTSYAPDLTKPLPVFDLRDVEEATLEKGIHKAPGCASIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBK1</accession>
    <name>A0A1C1CBK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">High-temperature-induced dauer-formation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBK1"/>
    <dbReference type="STRING" id="86049.A0A1C1CBK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01407"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03740"/>
    <dbReference type="eggNOG" id="KOG2226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="773"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="962" mass="106021" checksum="1F038AE646D203F5" modified="2016-11-02" version="1">MGASESKLIFKQGIFRLSEERNIAANDPYWTNVSLLAWRTALLLIWRQFWELPESVEDVFSLFSHTDIRRTRDAAIENLETLILAVTSRLIVLKNHPSFPDPDLAPERDALNCIRVLTRLLPYVYEAEQLAEWEERFFWGMRRRRTRRAQVSGEILFDDNQGDDTTPTENPQQEFEDAKPLAEELIDTLVDLLFYTGFTIPELPNAKSKVTYAIWQSGVGCKSSIPTSKELESNRCEVLRLLLTLSSKAMYMPSNVLPVQGVRTITYLATCPDKQIVLSVLCSLINTTIKANVGSWRLPYDHMVRKDSQQTLVVYSLQLLLTLLLYPVPEDATGSVPKNFYRHFFGRLHRPEDFQFLADGMTRVLSQPMQATASYLPGSQKSVKWAPEMIMLFWEVLQCNKRFRSFIIESNRAHDFVILMLFYAIEYKTDAARQGIVRMCVFVLQTMSVEASFGKNLNKRFEAQETLPPSIRVAHFTGTYADFLIISIHTLITGSKGKLDAIYPALLAIINNMAAYVQHLSLAASTRLVQLLSSMSTPSFLLANETNHVLLQALLESINSMVEHQYEANANLIYAIWRSRKRIEALRKFTLEGGQAEIERAAQRNKEAALSDSSNNLSRSSTMGVVSPSATPQPESAVDGTFAIGDSDDSDNEEPPTPSHSTHSIRTSRTPSVASSSVPEDNMPIQLTGMSEKARGKMPANAPTFSRQNSTTSLSATSTYTPGRGAVGLTPEWLESWLPDLPLHTLLTVIKVLSSHPLASPRNNSSDTTNPPSIASSRRSSLAADEALPSPATPTTTDMASTNMSSTPSSFRSQIPSTSTHPSIAAILASPSPIRVHLFEWSPLSLGWYMSVLWSLIFTAEMTIAPTSSTAATLTGQGAMAGPVGVWNGTNVKLFQVATEGKREGPSLSAPRGAVDAVGTRLVQGVQGLNLGGLVGRVGAGVRNASQGNIREGGIPGTTREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBK6</accession>
    <name>A0A1C1CBK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_01767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01767"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="94" mass="10466" checksum="DCF4F1395E9EAAD4" modified="2016-11-02" version="1">MGSRRHARILIMAACCVKMGSTGRDALKQSASSAFTHLLMRTILSKHMRQIDPRMDEMRQNGATPFSPYPAYPALAVPVRQPSQIPHHYTATSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCP3</accession>
    <name>A0A1C1CCP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mrpl38</name>
        <name evidence="7" type="ORF">CLCR_01342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCP3"/>
    <dbReference type="STRING" id="86049.A0A1C1CCP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01342"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09279"/>
    <dbReference type="eggNOG" id="KOG0901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000005">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_uL14_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT46242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="128" mass="14043" checksum="7E70F18220CFB79E" modified="2016-11-02" version="1">MLNCIDNSGAAVVECVAVMRKQRQAARIGDRIIVVVQKQKSFGPETPGGSSLSIANKVRRGDIRHAVVVRARKEERRKDGGLIRFDDNACVLINKNGDPIGTRLSSIVGAELRDKKWSKILSLAPMHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD66</accession>
    <name>A0A1C1CD66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLD5</name>
        <name evidence="9" type="ORF">CLCR_01300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD66"/>
    <dbReference type="STRING" id="86049.A0A1C1CD66"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01300"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09121"/>
    <dbReference type="eggNOG" id="KOG3176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="100"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein SLD5 C-terminal" evidence="8">
        <location>
            <begin position="198"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT46408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="263" mass="29544" checksum="08B697E4954BF755" modified="2016-11-02" version="1">MDVDISDILADVSRSQNYTSSSSHHYSSSDTDAFTDHQLLTRAWQSERCAPDLLPYPTDLMTRVMSRVQAQISRIEDLASGMSDDYTINGIAKQGGMQNANLVLAILQTDLSRTQFLVRSLLRQRLAKITKYATYYLAEHLDSERGTSATMSQSEVAFLRHHQALLGELYDSSFLNAFPQALRRLDDSSGGVAMVEGPDVSKAVIVRCLTEGTWSNERDLDDARDSGHDEGANVGLRMRRNEVWLVRWRDVRKGVERGEVELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD89</accession>
    <name>A0A1C1CD89_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD89"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02164"/>
    <dbReference type="OrthoDB" id="4159642at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="122" mass="13724" checksum="A43B527C69F82540" modified="2016-11-02" version="1">MYIGEQEPKYGDIWHIPSRCFVDVGFQKLDPFKKEESEPTSAALPSPRQSIDEDPLAPPPTPSKTNGSESNICRKLLRRLTLRKPAPCCISQTQEGPYEATRIEGRDYRVNGVIPARCESPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDA1</accession>
    <name>A0A1C1CDA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02128"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01194"/>
    <dbReference type="OrthoDB" id="4157183at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="195" mass="21103" checksum="681A995D83F13037" modified="2016-11-02" version="1">MCESHTIFHLCGHVNVKTIVQCADIIDKLLVSGTSIASNHQVCQDDVSDNVHVFPDICTRCRATGVIGDVMDAPGVKLEVMKAWESQRKRISAIGNNKNNDTVDTEDGEADKIRECENLERISLKDNVSASAVDRAGAFSSSTPATSSVSGSTCREPSPASTPDLSQIKARVMALRARTERLVMKIRAHNLPKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDB5</accession>
    <name>A0A1C1CDB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02147"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="155" mass="17336" checksum="E93A1241F6B6FA27" modified="2016-11-02" version="1">MSVRQVLFVDVSGRPSTEHYHSDSILLERRETHTRCYLDTLDTELQNGQGFVSSPARRARLRHFGGLLVCRQNFTSAPVMQSTTVFVLKLSIVKGDGARGRLVRLTYRVSSFAAFGDFIMVSARIDLTVKVIGPIYQQTHLELTLEIDSSGSSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDD7</accession>
    <name>A0A1C1CDD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_01782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDD7"/>
    <dbReference type="STRING" id="86049.A0A1C1CDD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01782"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01237"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01238"/>
    <dbReference type="eggNOG" id="KOG3745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5554140at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF1">
        <property type="entry name" value="RECYCLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Velvet" evidence="3">
        <location>
            <begin position="52"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="466"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="957"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT46509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1378" mass="152383" checksum="143981E3F301ADDB" modified="2016-11-02" version="1">MHAIAGNGTYPTQGSTMSSLANGNGIPPSPSQTSIATDDLSNYDLPDLPTMSRVWGKHAFVLVIQQQPQRARMCGFGDKDRRPITPPLIVKLLIVDSATNQEINYEANTEWSKLILSVDLWDVHGEHEDNCVRHNAAAPSISATTTTAYPAITQQIGPRAQQLYSYDPMNAPAYRRDVMVTPTPGNIPSSPYERPPAYPPNHQQGYNGHYQNPYNGAYPPRGLPQEMAPSPASSLQSRASQDVGSPGPNRSEPSKNLIGQCHSSLQKLDGLDEIPGLFFIFQDLSVRTEGWFRLKCQLFALGKLGLDGEEGVTGEMRNGLLVECPCLAATFTKPFKVFSAKKFPGVVETTAWSEKFALQGIKIPIRKSDTKGKTRKRNRGDESDEDEDDEQEEHWSTGSGIAQLALVSSAPCDFQRHDLQGKVTPSFSPSQTLGPTASMSKPTKPKALNKASRRDPLASLKKADMIISKPILPAEVLATLVDYLTVPDLLRFARVSRRMHEMVYDDARWVKRLRIMGCWNDSEARRRAEPPKTPTTPGRRKSTVDRNLINGKGRPEVLFDVDASPVYQTRQPSLLSPPKPRLVVADGFDVAETSSPQAISASELPVDHDAPLSVFSRVRSIRGQARQEYGKIYRLLAPFYQDLLSTSNPMKCRIFKDFDIPEQQVRLLANVRIFSASDFSPGSGRREQQIAEAVALFDTEALLEFRKGYEFRDIRGRMRQYARVMHTLNGGKSGIDLFLHDNKIINQKAELGSVSDCIDYSLGYGQLSLERVQAYFERLGNALTEENGIVQAVFPNANEVSLLLLEEVAKEILGPFLSELFEEARARGTSIYLRIISGTFQATKQFIEGAVLSDDTDEATIARCNAIGAQIFAPHLETYLEGELAFFRQKADSEIEQWDRALSEQAASTESFLMSNVNRQADKKDFMSSFKQVLMMPVNILPSFSGSQTAKTPLKKLNVEASTSSRPSTPIPGGPRAATPNLPQEAPTDELAAKAALMNTKLENIKSLFSIEIALNLVHAAKSSLDRASQFIALPGEAGESARTQCSAIFNLLVQTVGIRHVKTGFDKAIDHLSHYSPRETTDITTPATVQVAPLATFLELVNVGDLIQQMLDVFYESELVRLRISNRDDFLDVNVKEKRKFEAMLDERVAAGLGKGIDVLMDEVEYICATTQLPTDFYPELALQDDNTTTTHHPNTMSSILNGVAGRPASIASKLPVMDFSGQPTPTAQRVINLVGHHTSMLTGATEKSLLDVFITEVGLRLFTTLTKHIKRQRISCAGSLNLLSDLTAYAQFIATFKNPDLSSYFTALRSLAQIYLIEGTSDRDVREMSTIIADQDRYKGVFTVEEVVEFAERRSDWLLLRARVEGKVKGDGCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDK5</accession>
    <name>A0A1C1CDK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDK5"/>
    <dbReference type="STRING" id="86049.A0A1C1CDK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01800"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01291"/>
    <dbReference type="eggNOG" id="ENOG502SWU4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5341904at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1150" mass="126735" checksum="FF72A5AEA7AA9057" modified="2016-11-02" version="1">MRFGRRRSSLAADPVQTEPEARRRNRLSKPLTSNATKIQPSTSAPALSLQVPAQTKNASTTELPASPLSSISGTALRQHIRNDVLAREDDSHSPTRTSKHDSSWRVAYMVSRIEGKKPPAEIHQKRPQQQPLESVPLSPVRPQKRKSSLLRRLSLQRQPSLSRTPSYERVNSLKSETAVATTPTPSLDQIAESPSIPPTRRASFAPGTATRKASPIKSKQDIQAHKFKELEGPAARVVDLGYSDWESPPPRTVGRTGTPSDMGYSQLGGLRHGSLQIVNGRASPAFSEASKVSRQLLANHPPHRDVSSEYGDTEEEAEHFDLTPIQGNRPVPVERRIFSWEKDDDEVVPRTHPLQTVMSPEEETTTGNHISLMANEYIAELPASPFEQRRQSSPVGSIRRARSESSLWRASSCASLRRSPPIEKGLSELSPGSPSQPSLSPTGSVIRKKSFETVRGRGRRVLQVTTDHKHHASDSTSSWYSPVEPTIPADEAFQSALEFQVQLSPSKDGLKPFRAPEKSDSGYSSGNSLRSLQIAKRTPPPPVELEASPQVLNPTMGAATPQSGRPTSFLVTRPSILKLRKTEPNVPTFANLRPSVVSVEPAVAAMETAVPGPAADGPKPSKARKKLMKKRRPVSQSPGQISVVKVQSFEVESIPQVSPAARENLRIRSQTVPELQRTYMKSDIMGNTPGESQLDLSNTEFRFPSPGPVQSLQVKRSRSRSRPRSWFDRSKTDTSNPRGDAGISRAQANAIIDHFGTDGAGLGRSPYDLSSHGVVSQPPGPVPVNSAAPFQSRSMMDDRTAADLSRRRSRSLREREYTVPERRLSFNDRGGIPGKNLRPASFFSEAPPITAEMLEKAYRTSSMQRQPSWSTDLAPPPPPHSSRPSYLDYEEDESDPVAPPPPPHSPRPIDITADPWVAEAAAWKARRKSAGEALRRQAWDYQEYEGYPESSDNELLYPVIPPGQQSDWDQYLSPEKFSSSPQEYHRENRRSSLHHQVFRSAYEPLNGEPNEHESAYVRQSREHFMTHDTHYPRMTRSEEPSRHRALPQPRAANGAVSPRPHSRANSARSFASSIAEELHPRHLERQHPPPAFGRYSGGLAFGYEHGSGFGGSAGTRSSSGQAGASRKGVFLRASHGVDLGDVPVGIMARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDP7</accession>
    <name>A0A1C1CDP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 3-mercaptopyruvate sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tum1</name>
        <name evidence="5" type="ORF">CLCR_02041</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDP7"/>
    <dbReference type="STRING" id="86049.A0A1C1CDP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02041"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01355"/>
    <dbReference type="eggNOG" id="KOG1529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000001">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000033">
        <property type="entry name" value="Thiosulfate sulfurtransferase TUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="77"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="218"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT46629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="325" mass="36406" checksum="2382501FF66AA98D" modified="2016-11-02" version="1">MRAPTPTGFVPLWRPAAVRPLQSHAQHISSLRCRGFSSYLVTPKELDEALKKNAPTAISTAPKVIPICAAWFMPNDPEKRTGLQAFLKKRIPTARFFDIDEIKDQESEWPHMLPTCDAFADAMSKLGVRREDEVVIYDTEELGLFSAPRVAWTMRVFGHPKVHVLNNFRVWVQEGYPVETGPPQVPNITKYAVPAYNTDMVVKFAEMKTIGYDHGKEGSEDIQILDARSKGRWEGTEPEPRAGIRSGHMPGSTSVPFQELLDPDTKTLLPGEELRKVFESKQLDPQTPFITTCGTGVTAAIIEAALKEADFGTEHDRRLYDGSWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEL1</accession>
    <name>A0A1C1CEL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_02626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02626"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT46896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="208" mass="23448" checksum="9C735C00035EA53C" modified="2016-11-02" version="1">MFSSSYGPRIYKLLRIDTQTSLMIIGISGGLSIIYCSIGLYLIDKVGRVKPLIVCAFFLATSLLVNAVQAQYLNPANENQLRSMVAMNFVFSLFYSPLGIISWVYPAEIFPVEVRALGNAITTFCHWSINLIFAQFTPKALAAVGFRYFYLFFGFNLISMVCYMLFYPETKNRTLEDMERLFGSQTTATTEKGEITVHVEEGKGKLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFD4</accession>
    <name>A0A1C1CFD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Arsenite resistance protein ArsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">arsB</name>
        <name evidence="12" type="ORF">CLCR_02452</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFD4"/>
    <dbReference type="STRING" id="86049.A0A1C1CFD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02452"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02205"/>
    <dbReference type="eggNOG" id="ENOG502QPKH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="187348at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015104">
        <property type="term" value="F:antimonite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000009">
        <property type="entry name" value="Arsenite transporter, ACR3 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057:SF1">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="ARSENITE EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT47224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="401" mass="43880" checksum="6C2BA2D504910A4C" modified="2016-11-02" version="1">MSDPREDAGTGGEQKVIVDPPADMDAENQQLPKQVEEKRSVYAGLGWLDRLLVLWILLAITIGILLGNFVDGVGPALQKGKFVQVSVPIAVGLLVMMYPILCKVKYETLHRVFAHRQIWIQLGFSVVANWVIAPLLMLGLAWAFLPDRPELRNGLVFVGLARCIAMVGANTYCFNQEHTNQTAWQVLIWTGLAGGDEEYCAILVAFNSILQMVLYAPLAILFVNVISDGGGTEVAYSTVAQSVGVFLGIPLGAAIATRLTLRSINATWYDQKFLVWIAPWSLLGLLYTILVLFASQGKQVVHQIVSVVRVAAPLVVYFVVIFFVTLLITKRIGFGYKLAATQSFTAASNNFELAIAVAVATFGANSDEALATTVGPLIEVPVLISLVYVVRWIAGRWKWQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFF4</accession>
    <name>A0A1C1CFF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate carboxypeptidase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FOLH1</name>
        <name evidence="7" type="ORF">CLCR_02275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFF4"/>
    <dbReference type="STRING" id="86049.A0A1C1CFF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02275"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02238"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000029">
        <property type="entry name" value="Glutamate carboxypeptidase Tre2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF71">
        <property type="entry name" value="CARBOXYPEPTIDASE TRE2, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="292"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="479"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="726"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT47196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="853" mass="95684" checksum="D77C9CE57D85158E" modified="2016-11-02" version="1">MGDKAQYEHLPIPTYEEATSSRPASSQSRLGPEEISDDAERQGLLVSARNYRPPTVESARPSLDSLDGIEQDGENDVRREMQQMDIEDPLSDSSSNRSLLRYRLSKSFSSFTNSFSSLSLPSVRNYLSNIRWPSINYQQLDANRVVILGRLFGVFLIMGVLYVLIASDVLSFGRNRMGMGQMYDPESIRVFVQNHMNDHGHMQKYLEHITDFPHIAGTEGNYVLGEWVAELFKAGELEDVEMEKYEVYLNYPRKDGRRVAIVEPEDLKWEARIEEDQEQALVFHGHSKAGDVTGPLIYANFGSREDFKRLDDEGISVKGAVVLVRYYGSQGDRALKVKAAELAGAIGCIIYSDPAQDGFIQGPTFPDGRFMPEDGVQRGAVSLMSWVVGDVLTPGWASTPDNKRRLKPEESAGLNKIPSIPISWNDAKHLLEALKGHGKQFSGDWVGVPEVEYWTGDQESPKVNLKNIQDEEAKQPIYNVLGKMSGWEQPEKKIIVGNHRDAWCTGAADPGSGTAIMLEIVRVFGELRRLGWRPLRTIEFASWDGEEYNLIGSTEYVENREAQLREDGIAYLNVDVGVIGADFHASASPLYEHPLMHVINRVSDPSTGKSIREIWDEQGRGIEGLGAGSDFVAFQDIVGTASIDMFFKGAKFPYHSCYDNFEWMARYGDPDWNYHKAMGEIWALLILELADKPLLSFQVTSYAPALAKYIDDLDAYAKVQADSQSLDLHSLREATDFLSQQSQQFHNFDQSWRDFVFGSGGFESSAMGAARIQHNERLAQFETHLLDLREGGGLANRTQFKHVVFAPQLWSGYDDATFPGVRDMIDVGNWDEAQRQVDMIASIIKDAATKLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFR3</accession>
    <name>A0A1C1CFR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylanolytic transcriptional activator xlnR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Xylanase regulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">xlnR</name>
        <name evidence="13" type="ORF">CLCR_02267</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the xlnR/xlr1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFR3"/>
    <dbReference type="STRING" id="86049.A0A1C1CFR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02267"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02082"/>
    <dbReference type="eggNOG" id="ENOG502QUI0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5365785at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000004">
        <property type="entry name" value="Xylanolytic transcriptional activator XlnR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="12">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="112"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="492"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT47354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="874" mass="97178" checksum="4D54508352381B14" modified="2016-11-02" version="1">MLSRIPPQTHNSYSEYHDYAQRSDMITSQPQQLTSVLHPQPKYENDNLQAGRKRRESELDGNNESSDAAAVRRRISRACDQCNQLRTKCDGKQPCAHCTENSLICEYARAHKKRGRAPKKETDGQDEANYGTTAQPSANHQSAVRQSAGSRKYSSTSFAGRDGLVDANPLPSNNTPPSAGFDPNPHQNAFFANFDPSSGVGMTGAHPMHEMEPNMIPSIAQTQAIEFAVPNQAYAPSSLDPMHVQGATQGFGFPLGDDYSVAFMGKAPMVESPDWLALTSPMFINEPLPAQPRITDTLRYPVLRPLLPHIESIIPQALACDLLEQYFTSSTSAYLRPANAYILGYIFRKKSILHPTDPRPCTPALLASMLWIAAQTSDAAFLTAQLDARARICQRLLELTINMLKPLIHSHPNTSVPTPNPNYPQMTANDGGLGALVVPTHSGGHGVDRAQIDNLATYIHLATVVSASERKAASLRWWNAAWSLAREIRLGRELPPNPPEQDGEDSNQTNNNTDGHAGDNRKNSVDDARRNSIGYVSEEEREERRRTWWLLYMQDRHLALCYNRPMFFLNKECEGLLQPLDDEIFQAGRFDRASDPALRRRGLNIECTSHSVFGYFLPLMVILGEILDLNHARNRPRFGPRANKAKNWDDHTDEITLQLETYGQSLKDFEAAGGHFQDTSHNDVVTPSVVSAGTNESHSASELALQTKTVVAYGTHIMHVLHILLTGKWDPIALLDDNDLWISSQSFVTATGHAVSAAEAVAEIIEDDPDLSFMPFFFGVYLLQGSFLLLLFADKLQGDVSPDVVKACETIVRAHEACVATLDTQYQRNFRKVMRSALQQVRGRIPEDLAEQQHWRREVLALYRWTGDGTGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG02</accession>
    <name>A0A1C1CG02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG02"/>
    <dbReference type="STRING" id="86049.A0A1C1CG02"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03625"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01940"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34175" checksum="3128F64920F2B85F" modified="2016-11-02" version="1">MRIETRSFVDGGFGLSNNPSWESQVHYHRNHDVTTNRQLVMINLGTGSVPADANVGRLQQRPWWTRLVPNGLLKAMGLVSDLVKMATDSEQPAEQLRYLSEDHPDQLFFKRFSADTGIHDIQLDDWRAASGVDGTGIIEERTQAYLQDPAVLTELRHAAKKLAEVYVRRHEQVEIPAMAALDRRQSVDLSISVVVGEGERSRIGLPGHSRALTPESSADAIPSLVAGSEPTRSPNSSPPRTPEPGRNPYPAMLGTETKEILQGQGQQFKENVVSSSGFLGPISSDRSRSPRARRAATLPVSWDWGLGRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CG37</accession>
    <name>A0A1C1CG37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fksA</name>
        <name evidence="14" type="ORF">CLCR_03242</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CG37"/>
    <dbReference type="STRING" id="86049.A0A1C1CG37"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03242"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01956"/>
    <dbReference type="eggNOG" id="KOG0916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1339"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1391"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1508"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1594"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1638"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1676"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1705"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1773"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1837"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="342"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT47422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1929" mass="221024" checksum="3266CF5C8473F5A7" modified="2016-11-02" version="1">MSGHPHQGGYDDGYNGQHHGNDAYYQDDQQHGYHDQYDYGHQQHGGEGYYDESGYYNADASNPYHNDGGYYEGHQGYQDDYYDGQYYDQGAAGQHPQGQRPRRRGHDSEEDSETFSDFTMRSDMARAAEMDYYGRGDERYHSGYEGQGGRGYRPPSSQISYGGNRSSGASTPIYGMDYNNALPAGQRSREPYPAWTSDAQIPLSKEEVEDIFLDLTAKFGFQRDSMRNMYDHMMTLLDSRASRMTPNQALLSLHADYIGGDNANYRRWYFAAHLDLDDAVGFANMKLGKANRRTRKARKAAAKKAKENPQNEEATLEALEGDNSLEAAEYRWKTRMNKMSQHDRARQIALYLLCWGEANQVRFMPEALCFIFKCADDYLHSPACQNRVEPVEEFTYLNNVITPLYTYIRDQAYEIIDGKYVRREKDHNRIIGYDDINQLFWYPEGIERIVMTDKSRIVDLPPAERYLKLGEVNWKKVFFKTYKETRSWFHLLVNFNRIWVIHLTTFWFYTAFNAPTLYTKNYQQQLNNKPNAPAQWSAVALGGTIASLIQILATLVEWSYVPRKWAGAQHLTKRLLFLIGVFVLNIAPSVYIFGIKQTGQISLILGVVQFLIALATFFFFSIMPLGGLFGSYLTRNNRQYVASQTFTASYPRLKGNDMWMSYGLWIMVFAAKLAESYFFLTLSFRDPIKILSYTKIQHCQGDKILKDYLCKYQPQILLGIMFFTDLILFFLDTYLWYIIWNCVFSVARSFYLGVSIWTPWRNIFSRLPKRIYSKVLATTDMEIKYKPKVLISQVWNAIVISMYREHLLAIDHVQKLLYHQVPSEQEGKRTLRAPTFFVSQEDHSFKTEFFPSQSEAERRISFFAQSLSTPIPEPVPVDNMPTFTVLIPHYGEKILLSLREIIREDEPYSRVTLLEYLKQLHPHEWDCFVKDTKILADETSQFNGDYEKSEKDTAKSKIDDLPFYCIGFKSAAPEYTLRTRIWASLRSQTLYRTISGFMNYSRAIKLLYRVENPEVVQMFGGNSDKLERELERMARRKFKIVVSMQRYAKFKKEERENTEFLLRAYPDLQIAYLDEEPPQNEGEEPRLYSALIDGHSELLENGMRRPKFRVQLSGNPILGDGKSDNQNHAIIFYRGEYIQLIDANQDNYLEECLKIRSVLAEFEEMTTDNVSPYTPGLPPTKTNPVAILGAREYIFSENIGVLGDVAAGKEQTFGTLFARTLAQIGGKLHYGHPDFLNGIFMTTRGGVSKAQKGLHLNEDIYAGMNALIRGGRIKHCEYYQCGKGRDLGFGSILNFTTKIGTGMGEQMLSREYYYLGTQLPLDRFLSFYYAHPGFHINNMFIMLSVQLFMIVLINLGALRHETIICFYNRNVPPTDPLRPTGCTNLKPIMEWVQRCVVSIFIVFFISFVPLVVQELTERGFWRAATRLAKHFASASPVFEVFVCQIYASSIQQDLSFGGARYIGTGRGFATARIPFGVLYSRFAGPSIYLGARSLMMLLFATITVWGVWLLWFWVSLLGLCISPFIFNPHQFAWNDFFIDYRDYLRWLSRGNSRSHASSWIAFCRLSRTRLTGYKRKALGVPSEKLSGDVPRAQFTSVFFSEVVGPLVLVCLTLIPYLFINAQTGVQGADLKDPTNSLIRVAIVAFAPIAVNAGVLAALFGMACCMGPVLSMCCKKFGSVLAAIAHGVAVIMLLAFWEVMFFLEGWIFAKALLGMIAVVALQRFIFKLIIALCLTREFKHDTSNIAWWTGKWYSMGWHSMSQPAREYLCKITELGFFAADFILGHIIMFIMLPALCVPYIDKFHSVMLFWLRPSRQIRPPIYSIKQSRLRKRRVIRYAILYFIMLIVFLVLIIGPVIVRKYINSLPEIPMDLLQPTGQNNNDTTTGVTGSALVNFGQDAGTAAATQAAATSSNSNDPFSFGGGGDRFVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGK1</accession>
    <name>A0A1C1CGK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fcp1</name>
        <name evidence="10" type="ORF">CLCR_03300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGK1"/>
    <dbReference type="STRING" id="86049.A0A1C1CGK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03300"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10402"/>
    <dbReference type="eggNOG" id="KOG0323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000142">
        <property type="entry name" value="Similar to FCP1-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="160"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="542"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="420"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="659"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="727"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="691"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="810"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="823"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT47640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="851" mass="94934" checksum="DD1C004833A42187" modified="2016-11-02" version="1">MLLRLPKNLHYPITITKIEKLVGDPVARNDAIFLYSYTIKLREEERYEVRKEEDIPWVEKKFVTHFSSTLDGTIKAWRVWQGDVLTAPVDVCEIEEECTHAVQALGMCINCGKDMTIVAVGSETTDADRAPIRMAHDTAHLTISKEEASRIDEEAKRRLLSSRKLSLVVDLDQTIIHAAVEPTIREWMEDKDNPNHDAVSDVRAFQLTDDGPGMKGCWYYIKLRPGLAEFLDHISQLYELHIYTMGTRQYATEIAKLVDPEKKYFSDRILSRDESGSMIAKNLERLFPVDTKMVVIIDDRGDVWKWSANLIRVTPFDFFVGIGDINSSFLPKKQEIQATPTAEPKKITANGADDGANGEGEPNGKAEDGTSTIQNGTAALEQLIAMSGSDSPAVRELQTKDQEEIIKVQLEDKPLLKMQLQQDQKDEAEAAANGEAATSQSTESDSSDSSDSSESNSNPKQKGRHSILKNDDEELIHLEATLTKVHEAFFAEYDRMRLGGKGGRVAELTGKRKEPLPSRDDNEAQSLELRFVPDVKRVMPAMKMRVLAGVKIVFSGVLPLGTDIQNADISTWAKTFGATITDKISRDVTHVIAARPGTAKVKQAVKRGIKVVGTPWLIASMQQWRKLDERPYLLEGVQKQKHETSSELGDNLDKAGGNVNDFLLSSSDGETTGLDTEDDQPRRKRLKVDTSNEDEAEAYEEVVDDGSPVTINQDEWADIDAELKEFLGSDAESESDTDSVSSALSIRDGRRGKRRRDDDDDGDNSSASDVDRSPGRRRNGTGSGLKKVKNIDSERESEATDTPTAGTTEEQIRLEQRQAEEAQEREDEAVEDSDDELARELERELEEYDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH66</accession>
    <name>A0A1C1CH66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative pre-mRNA-splicing factor srp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_03682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH66"/>
    <dbReference type="STRING" id="86049.A0A1C1CH66"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03682"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04490"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12467">
        <property type="entry name" value="RRM_Srp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000123">
        <property type="entry name" value="Pre-mRNA splicing factor (Srp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034403">
        <property type="entry name" value="Srp1p_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT47864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="217" mass="25803" checksum="72C79A5BB44B6E51" modified="2016-11-02" version="1">MSSRSGTTLYVTGFGHGTRARDLAYEFEHYGRLVRCDIPAPRTASSRLFAFVEYESRRDADDAYHEMHNKRIGRDDVLKIEVRKAPSQLHSQWLTTLSQWARTPPSATWRYEAGRDRGRRERSPPRRSGRSPSPRRRDYSPRKDDRRDRDRDDRRDRDRDYDDRRRSRSPADRDRDRDRDMKDDRDRRDDDRDAGANGDDRKGMMEIDSEGAWPNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH73</accession>
    <name>A0A1C1CH73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_03620</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH73"/>
    <dbReference type="STRING" id="86049.A0A1C1CH73"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03620"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04491"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="16"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="113"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="217"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT47863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="320" mass="35212" checksum="E44258DCE15B545B" modified="2016-11-02" version="1">MSTSDILLPVREFLSAPFTAAFCAGGVAGAVSRTVVSPLERLKILYQIQSAGRNEYKMSIVKALKKMYTDEGWRGFMRGNGTNCVRIIPYSAVQFGAYNVYKRFAEPSPGADLDPLRRLICGGLAGITSVTFTYPLDIVRTRLSIQSASFAALGKHEGKLPGMWQTMVAMYKNEGGFLGLYRGIIPTVAGVAPYVGLNFMVYESVRQYFTEPGEKNPVWYRKLAAGAISGAVAQTCTYPFDVLRRRFQINSMNGMGYQYKSIWGAITTIVAQEGFFGLYKGIVPNLLKVAPSMASSWLSFEMTRDFLVGLKPEPDAAEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHA4</accession>
    <name>A0A1C1CHA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General alpha-glucoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MAL11</name>
        <name evidence="10" type="ORF">CLCR_03418</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03418"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04529"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF51">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="52"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT47821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="527" mass="58024" checksum="A27DE859B1E20533" modified="2016-11-02" version="1">MEKASIHDDTKAIDSIIEHVAPKIEQARIAAEEEHNLSVREAITKNKLVVFWCVFFAFSGVAWGFDAQVNGAMVSVPQFRSTFGYMFTNDKGELDSVIPASWLSGFNSISSVGQFFGGFLCSWLSDRLGRRWSLLVGLALVSGGIFGEVFSNTRPAFLIGKLILGIGLGFYLTIGPLYCSEVAPLVLRGMITGGVNFAIVIGQLLSNAVIKRFGERTDRWAFRGPFAIQWLFVVILLVGIPFAPESPWHYVRRGRMEDARRSLERLYGKDVDVSPKLAMIIRTVEEDAELSKSARWDQCFRGTNLVRTTISVGVFACQHLSGIVFVLGFSTYFFELAGIETTHAFDLGVGVTACGVVGVIISWAAINTLGRRKLFVWGMIGMTIVLVLMGILDVVHTSAARWVQASCTVVYALIYQITIGCIAFALLGEVSTPALRAKTVGLATACQAVFGTVMNIVVPYMVNPDKANLKGKVGFVFGGACLLGTIWSYFYIPELKGRTFQEIDYLFQHRVSPRRMGKYNVEDVNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHI7</accession>
    <name>A0A1C1CHI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endonuclease III homolog</fullName>
            <ecNumber evidence="8">3.2.2.-</ecNumber>
            <ecNumber evidence="8">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="8">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NTH1</name>
        <name evidence="11" type="ORF">CLCR_04106</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="8"/>
    <dbReference type="EC" id="4.2.99.18" evidence="8"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHI7"/>
    <dbReference type="STRING" id="86049.A0A1C1CHI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04106"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08099"/>
    <dbReference type="eggNOG" id="KOG1921">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000001">
        <property type="entry name" value="Endonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="10">
        <location>
            <begin position="233"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT47932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="467" mass="52080" checksum="D28C4A1EB611D5A7" modified="2016-11-02" version="1">MRTSRISRDTTRIFSALSPNARTRRSTRSSKRLASFALGYDGRVVVKEEEEEEEAEEEQEAQEVGTPTSEEPPRSPLIPDIEDAVSTSRRSSRKRKFGAETPLRDSVATETVTKHETAEASPSKTKEEDADSDRNELGDEAVPFIALPSGRGRARARAKPKIPARRMTSPSGAATGKTRIQAPSNWEEIYSIIKAMRQRNPTAPVDTMGCEDLYWRGAPPRDQRYHTLTALMLSSQTKDTVTAAAMQRLHTELGARDNDGEGKLQLPQSTLTIDNVISCDATHLDSLIGKVGFHNNKTKYIKRVARILKDEYHSDIPDSVEGLVRLPGVGPKMAYLCMSAAWGRDEGIGVDVHVHRITNLWGWHKTKTPEETRMWLEGWLPRDKWHEINKMLVGLGQTVCLPVGRRCGECGLAGTGLCKAEIRGWKATERRVKKEKLEICADAPVQAVNVEVQERKIVTVKEELVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHP5</accession>
    <name>A0A1C1CHP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04478"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="72" mass="7891" checksum="ACD56B147F6B60E6" modified="2016-11-02" version="1">MSGPERQVSCRYFGALLCDENQTQEALRIEDGHRGTRVAGGRMTTKAESSALVRNTQGSPASNSKLEPRRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHT3</accession>
    <name>A0A1C1CHT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04364"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08191"/>
    <dbReference type="OrthoDB" id="5386823at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="146" mass="15562" checksum="4530085038FD40C1" modified="2016-11-02" version="1">MELFHAVTQSIGNVLTCDYFDTFKAFKMEGNKTQDKTMDTVPGGETPQYESIKTETVPASKQRGQLGDGPNTSETATAADQERGQKTAENIRYGQNISEVGMGGKTTSQTGEAGPQAGYGGAPDRSDDQKDSRPQQRYGEGTGIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI36</accession>
    <name>A0A1C1CI36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative hscarg dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_04188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI36"/>
    <dbReference type="STRING" id="86049.A0A1C1CI36"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04188"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08334"/>
    <dbReference type="eggNOG" id="ENOG502SHS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT48185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="346" mass="37930" checksum="C6453FD7D9BF975D" modified="2016-11-02" version="1">MSKLIVVLGATGTQGGSVVDTFLGQSGWKIRALTRNANSGSAQKLKEKGVHEVVTATLDDVASLTEAFKGAHTVFSVTDFWGLYQDPANTEKAAATGLPKNVWAARVEEQQGKNVFDAAAHTAGLERLVFSGLSHATKWSRGKYSHVYHFDSKARAAEYGREEHAELWAKTSILQVGFYLSNLLTSPFMRPRKDENGLYVFAHNFPMALKLPLIATEEDTGPFTRALVEVAPGKNLIAYRAWMTLDEYLDIICRVTGVKAVNRQVPLDASSGSIPEELVAELTDNADYFEEFGYEGRDDPTLVHPRDVSLDLSCTEKTGTDHDVLLAWCGCTTPVCRRLGEEAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CID5</accession>
    <name>A0A1C1CID5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CID5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04046"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08415"/>
    <dbReference type="eggNOG" id="ENOG502SJA0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5400409at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="488" mass="53591" checksum="C6F6B6C16656EFC0" modified="2016-11-02" version="1">MASPRPSLVHHFRLLRGVNGKMSAVISAVDYEGEEERRDGRTLDFNIESAGLVPLYAVSFDQGPLSVILKTESVMAELAFRHVDELLRFQRALTGYKVYQDYTQPSVVLELIMSDRKTPRVHTAHVQLWIAKELDGRASTGPGSDSDLDASSRRTSTASPRSSPTAPYPGGGSHLNVRSVPPTTDPLINRLSHFNIGQRQAWHNGGPSSNGVSPGRGLPRPFPFHAALPPQGINRADSMASIQTTTSASTARESHSIFSSQSKASRSTSATSRKLASPDFGTGRGYVYQKPVEPLLVLLLKSTPDSTVQVGPAHGVKNAPPPFSVVIIQLDENTAPNYERCSCQSHPDQCDITALERDRGKDDLSARIVEADELEAWDLMRLRPSTRQGQVSADAATAATFFARQPKPLPKLRRVTLKFPDVQSRYRLSGRPCSCNKTRTTGELRACLAEKHQGLLGQIRQYHKKELERFEEAQRRRSDVILGPMASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIN8</accession>
    <name>A0A1C1CIN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CCCH zinc finger and SMR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_03904</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIN8"/>
    <dbReference type="STRING" id="86049.A0A1C1CIN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03904"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08504"/>
    <dbReference type="eggNOG" id="KOG2401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.110:FF:000002">
        <property type="entry name" value="CCCH zinc finger and SMR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="8">
        <location>
            <begin position="589"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="674"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT48368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="715" mass="77924" checksum="E4E6F9F39DDE2F12" modified="2016-11-02" version="1">MISDEQYDQCRPVLQDAAIEEEEKIERLEELLGKEYGLKGSALENAVLDALWKHRNAQRGESAETPLRHHVIRKSSPAPWQVNRAPTPLGSPPPLSSSPAMSAGFPASRPSFSRQKSSMQSPFVSPRPSPRLAMAQPIPHSPSLNAYEFSDASPAPDIYGDYGHENVDWLLADETGSNAPSTATGGLSAAAPEWVPQPDMSPYDILRSVLGDRKTDDEIEQALNKNSYDLGATIASLLGTDTADQQYTGVPSTEAAVLVGKSMAVHPVRPASPSTHKSPIVCKYWLASGSCLRADCRFAHDTSAYLCKYWMNGNCLAGDACQFSHDPALLVNQVTLGDSTAIQAFQLQDQYDQFPALGHPNARSALQAGLIAGNTFVPANPKNRGTLGLGPGSRPHSRPNSRHQNRPETPSSLSMDDPDAFPTLGSAKRGTKHHGHRSRHGHGSAEKETPSSLADVVRMSPSPALGQQRKVETGRKIRTYGGSESAAARKIPEPQHIPWLETGARANQQYLKYRQEAIKHGSIRNKFLQSAAQAWNRNDARAAKALSLRGQAENDAMRKAHREAAKALYEERNKHLSTSRVDDDEELYIDLHGLHPEEAVEYLENILLSHSNTGRRIIYAITGTGHHSKNGKDKVGKGVRNWLNEWGYTFREFSVPGERGGYIGGVLGIDITSHRRQPVSADEKTEGEENASPTPAVATAVGTKIQVLKRDEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIU9</accession>
    <name>A0A1C1CIU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein AkeP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIU9"/>
    <dbReference type="STRING" id="86049.A0A1C1CIU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04206"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08528"/>
    <dbReference type="eggNOG" id="ENOG502RZSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650831" evidence="1">
        <location>
            <begin position="26"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="165"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="363" mass="38725" checksum="DA9387D3BEEB5AF6" modified="2016-11-02" version="1">MTPPPATAIMFVTVLIFCCTALSVAQNDSFYTASPDFQIILGSHPKVTLLAESEQPLFHEGGVYYPPTRSLFVTSDVVPDPSTANGTMQIISHVTGNLTNAATVQVTQLNATSHAIPFPLGGYRYLAASNVLVWAGQGSPTQPWGLWFLNPEPPFNATQVLSSYGVYEYNSPNDVAVTPSGEIYFTDPIYGAEYGFRPAPQLPNQVYRYNPASGTVRAVADGYIRPNGIGINQDGSIVYIIDTGAQPGDGTIDATGPRTIYALDVQGRTKNGTGGFLCNRRLFSLPSFGGAKGVKTDTLGNVYVGLDDGVSVFDDDGNLLGKILIDDVANIGFGEPGVLFTMGQTKLWRIDLSRAIVGSSFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJD3</accession>
    <name>A0A1C1CJD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_11297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11297"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="165" mass="17739" checksum="35B4829D7A4CD15A" modified="2016-11-02" version="1">MDSILNRLVIRSQHNGDVTCPLESRGFTAQHQLKLTGYGWQGGNGPQDDGLVEICQRQVILTGPGPQRLAGLGTSSVGAGDAVDRIGSNGESSLLSKHSAGALTSTESTQGAKRPDGKEPRDQMRSSRTPSQSFWCRIINRIPQAWTKAQDANRRGEAGAQRWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJI9</accession>
    <name>A0A1C1CJI9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein RTM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RTM1</name>
        <name evidence="6" type="ORF">CLCR_05012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJI9"/>
    <dbReference type="STRING" id="86049.A0A1C1CJI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05012"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03214"/>
    <dbReference type="eggNOG" id="ENOG502QURG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT48685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="297" mass="32992" checksum="653FD0BFA4DD6632" modified="2016-11-02" version="1">MATATSNATSTPDSHSDSNFRLYRYDPSLGPAILFIALFFAASSLHLYQLIRTRTWFFIPFVVGGFFESVGYIGRAIGAQETPDWSVGGYVIQSVLILVAPALFAASIYMELGRIMQLTDGGSRSLINTRWLTKIFVAGDVFSFLMQSSGGGIMAGGSEDSMKRGENIIIGGLVLQIIFFTFFIVVASVFHYRMHKRPSARVLADITIASAWKKHLHVLYGGSWLILIRSLFRLVEYAQGNDGYLISHEWFLYVFDAVLMLATMLLFAFVHPSELNALLKGGRGRAVRRVVSVYSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJW6</accession>
    <name>A0A1C1CJW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="14">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SDH1</name>
        <name evidence="17" type="ORF">CLCR_04688</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion inner membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="14"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJW6"/>
    <dbReference type="STRING" id="86049.A0A1C1CJW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04688"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03138"/>
    <dbReference type="eggNOG" id="KOG2403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045273">
        <property type="term" value="C:respiratory chain complex II (succinate dehydrogenase)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 13 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="4 14" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <keyword evidence="17" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="15">
        <location>
            <begin position="3"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="16">
        <location>
            <begin position="400"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="344"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT48766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="535" mass="59257" checksum="D76A945C9284C8EC" modified="2016-11-02" version="1">MHEDDWRWHMYDTVKGSDWLGDQDAIHYMTREAPRSVIELEGYGCPFSRTEDGKIYQRAFGGQSQKYGKGGQAYRCCAAADRTGHALLHTLYGQSLNHNTNYFIEFFALDLIMEDGVCKGVLAYNQEDGTLHRFKAQNTVLATGGYGRTYFSCTSAHTCTGDGMAMVARAGLPNQDLEFVQFHPTGIYGAGCLITEGSRGEGGYLLNSEGERFMERYAPTAKDLASRDVVSRSMTMEIREGRGVGPDKDHIYLQLSHLPPEILHERLPGISETASIFSGVDVTKQPIPVLPTVHYNMGGIPTKYTGEVLRINDQGKDEVVPGLFACGEAACVSVHGANRLGANSLLDLIVFGRAVSHTIRDNFSPGQTQKEIAPDAGAESIEVLDQIRNSSGPKSTAEIRSAMQKVMQADVSVFRTQESLDEGVKKINEVDQTFADVGIKDRSMIWNSDLVETLELRNLLTCATQTAVSAANRKESRGAHAREDYPERDDENWMKHTLSWQKKPHGKVELGYRAVVGHTLDEQECKAIPPFKRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK17</accession>
    <name>A0A1C1CK17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Esd</name>
        <name evidence="8" type="ORF">CLCR_05030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK17"/>
    <dbReference type="STRING" id="86049.A0A1C1CK17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05030"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03116"/>
    <dbReference type="eggNOG" id="KOG3101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="288" mass="31609" checksum="488D838BF63CE77C" modified="2016-11-02" version="1">MSVNTQATIASFGGKLLKLAHNSSTLGCESKFNLFLPPQSQNSKVPLLIYLSGLTCTGDNCSEKGFFQHGASKRGIAVLYPDTSPRGIGIQGEDDSYDFGTGAGFYVDATAEPWSKNYRMYSYITEELPKTVFDAFKDQIDSSKVSITGHSMGGHGALSLFLKNPGKYKSVSAFAPISNPLKAPWGEKAFKGYFGEQDWQKKGAEHDSTELLKKWKGGDLDILIDVGTGDNFYKQGQLLPENFIAAAKEIGQEKGVNVRFQPDYDHSYYTMATFADDHVDHAAKYLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK48</accession>
    <name>A0A1C1CK48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK48"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05233"/>
    <dbReference type="OrthoDB" id="4120262at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="101" mass="11127" checksum="5FA4CC471C1B142C" modified="2016-11-02" version="1">MPPMRLPINRLGQAVRSFSSAAPGVLGTRQQQFYLHRHILHHGPSQRILSKASAASHGWTQVPEAVRDVTSYLALGALTSQAAFLIYCWDQEADLGDFLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKK4</accession>
    <name>A0A1C1CKK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKK4"/>
    <dbReference type="STRING" id="86049.A0A1C1CKK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04721"/>
    <dbReference type="OrthoDB" id="4112385at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF26">
        <property type="entry name" value="FAD-BINDING 8 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="45466" checksum="0013BDC3C8CB78CA" modified="2016-11-02" version="1">MDFSEVYAIAIGAVFGAALLLNGWPWISRCVRPLSPLTSKYLVYRYVLHRHRFMGPWSLAGVLLQLIYVTGNILCIALRMRHGQTRISTLSQAGQRAGTLSIINLIPLFAGLHLSALSDLLGVNLRTVRQIHRSAGVMASLLMVFHALVALRSQPTFALNQAPNLFGVIALAALVVFAVWRHLPSGSSFARDSLYSLNGFFRPGRAGAEITHVYGAIRLRIQCRKPVQFQLGQYVNLWMPSLPYLKRLIRGYNVRRLRAQRVHLVWQIRDLNLALAAETLLNGALDEDTLDDGWILDISIYCAQDDIPRTSFGKRAHVFAGPAPLGEIFQAERAGRSTEKKRMQQVDWNTQRLVSGDDIEYESTVGREVNMLVTVSATDEVRDNLRQVVRDHLSEEVQFFELDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKL2</accession>
    <name>A0A1C1CKL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKL2"/>
    <dbReference type="STRING" id="86049.A0A1C1CKL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05066"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07315"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="295" mass="34449" checksum="77376516B1EB5FDA" modified="2016-11-02" version="1">MWTPPKLPYYVAPDQLPAPLPTTQEIRASSTILHQRSTQTVKAIGMHFVVKYGPGTKTREGNNLIFLHQHLSSLPIPRLWAMYEEDEDVFIIMEHFEGDTLQDIWPSLQASDKSAITKQLRSIMDQLRALKPPEPLFYGSLERGPIPYFLFNSMEPNPTINGPFVNEYDFIQGLVRNLRTIDELNHRDSYKTDFYEQNLSSCFRIGRPTLTHGDIQRKNIMVQRTCLQGDGCEPAFRLMIIDWEDSGWYPAYWEFFATFTSLRWDDDWSSRIQDFLVPWPVETAALNMIYHDLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLA4</accession>
    <name>A0A1C1CLA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcriptional regulatory protein DEP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_04669</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BRMS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLA4"/>
    <dbReference type="STRING" id="86049.A0A1C1CLA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04669"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02655"/>
    <dbReference type="eggNOG" id="ENOG502S14R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20886at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000002">
        <property type="entry name" value="breast cancer metastasis-suppressor 1-like protein-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="469"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="593"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="654" mass="72835" checksum="F37255100E14A15B" modified="2016-11-02" version="1">MDLAADSLLALSNATTTVAAKEEPLSDDDRSSSLSELEEDLEDGEDEEVEPTPLGDADSEAETERLQVTPENLQRKKPFESSPSKLAQRQDVDMRPEIESLTESLVSSPISSHPDSDNDDPLSDGPDADEELPIEAVPAGTSSPNKRKREESGSDLEEAPRSRRRRRPGSPESDDEKSELDSDGDEAPAPQTRKPIVEPEVEVGEQTEHAPEVAEEEQKEIEKTDTSEDSKGKSRSRLRRKTKEPVIPEPQPEEGEDAEAAEDSEPADADENDAEATLKSEEEQARRMAAMDSLMAIEKQFATLRDRLYDERIAAINHELQLLQEPKPAHPELIRQVEAVQRYRDEKFQIEQKLLVYKVGALKNKAVAERSQIHSQYFQTVRDIRERHLERISEHFYRIQRDRFKADSSIPSFSIPFPEKRSQQILQQTAYNKEVSILSGVAKYVGFPAAPELEATRQKDIEDDIQKMGISPAQIRPARPMQRPAMQSQMSGPQAEEQFLEQTPWANPQHPIHRLSRQNSNRSPMNEFLTPANQQRNMPDNLQPPGGSASTIADPSASAQASSAINTPHDGQHSASRTEVQAGPSALHNFRIHSASPLDKRRHPEPNDQPGKDKDVMATARDTGSSPLTSRAYFNATAPRPPAITAGTGRFSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLM8</accession>
    <name>A0A1C1CLM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U-box domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLM8"/>
    <dbReference type="STRING" id="86049.A0A1C1CLM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04612"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03338"/>
    <dbReference type="eggNOG" id="ENOG502REND">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039510">
        <property type="entry name" value="Vint_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032838">
        <property type="entry name" value="Vwaint_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF156">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14623">
        <property type="entry name" value="Vint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14624">
        <property type="entry name" value="Vwaint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="75"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="748" mass="81385" checksum="B2AA044FF415805F" modified="2016-11-02" version="1">MVLRAKVFRHSIQSTVTTGTAPLDEFADLALQPRTRAHGDQAQVEIHPLRESDAFIVSIQPPKVPEGGLQRASCDIVLVIDVSGSMSAAAPLPEATGDNDKEAAGLSVLDLVKHAARTILETLGPGDRLGIVTFSDDATVVQELTFMSASEKKKARQRIESLRDESSTNLWAGIRSGLELFSTTALVDNVQGLYVLTDGMPNHMCPKQGYVNKLGPILKEAARKRASIPTIHTFGFGYEIRSDLMQSIAEVGKGSYAFIPDAGMIGTAFVHSVANLYTTAGTSASLEIQLSNDITLESTGGTSLEKGEHGHLLELGNIQFGQSRDLVFLCRPSSQEDVEITARLNYRIADGSARTSQARALFSDRTGLPQDMVHYHMHRAQICEFLSTLFPLKANGEHTAITGNEALTDAHARLRSIVTAIQSSPFGATLEVKALLDDLVGDEPHGQISKALVSTKDRNYWQKWGRHYLPSLLHAHQRQMCNTFKDPGPLLYGKDSPLFVQCRTELDAAFDSLPAPKPSRPPRVVYTYDAKGRVSGSRTVAYKQVSMASYNSSSAPCFEGNCLVKMGDGDSKPIKSLRPGLLVWTPMGARAIAAILRTRIRGHRQKLCRIGELLVTPWHPVQHDGKWVFPSQVATRGVSFKGSVYSILLTPFPHPNGHAVEIGGQLCVTLGHGLVSPSQSKNDVRAHPFFGSYRCVAVALLRLPVDKNRHLRCGGMMRGPKSGLACGFVKPMAAKRVVGRLGKTLRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMJ2</accession>
    <name>A0A1C1CMJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMJ2"/>
    <dbReference type="STRING" id="86049.A0A1C1CMJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07133"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09964"/>
    <dbReference type="eggNOG" id="ENOG502S039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058268">
        <property type="entry name" value="DUF7962"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045073">
        <property type="entry name" value="Omega/Tau-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE, GST, SUPERFAMILY, GST DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260:SF679">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25907">
        <property type="entry name" value="DUF7962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="372" mass="41137" checksum="CDC59E3F2B70E7C4" modified="2016-11-02" version="1">MAATEASETPPVVLFGYDSSPFTQKVRLALKLKQIPYTFVVVPSMMPRPILKDSFNVTYRKIPVVAIGREIYIDTSLILEALEHHFPPSRGYGSLYPSGHAATYRSLIRGFASYWTDRPLFRVTTGLIPATVWRTHFGVDRANLIGHTLDAEKLARKVPQNLSGLDLQLSLLEPLLVGDGKKWMFEGDKPSAADVAVWYQLDWGEKISRGEGINDLTGGGARDGDGEGMNSVFNKERYPALVSWFERFKGYLDSLPSTETRTERTDDAGIEKTLQRLKDTKLAERLPLSPTPAGPHHELDRRNGLVIGAEVTIAPDDTGRDSPTVGTLLAIGPEEVVIRPQKTDGEGPRVGDVRVHFPRIGFVIRPVGLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMU4</accession>
    <name>A0A1C1CMU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMU4"/>
    <dbReference type="STRING" id="86049.A0A1C1CMU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07406"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08694"/>
    <dbReference type="eggNOG" id="ENOG502S40X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650918" description="Extracellular serine-rich protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="30685" checksum="0A68A18FD273DD33" modified="2016-11-02" version="1">MSLKTLLVSTLLAATAIATDHGSGGSSYGSGGSWGGDSGSGGWNSWPSGGGQAPPALAAPSCPAGCMPFPTGPPPAAETQPGQLIVQVVSVADANGSLKYFPDKITAPVGSIVQFQFHPKNHTITESSFAEPCKPIASNLTSPTRPGLKSGFVPVTGMEPFTPVYNVLVNDTKPIWIYCGQTNHCQKGMAMVINQNDSSPNTIEAYISKAAQLPIASTPPPPPSSAAPPVEAPPASSPPPPAFGGGAPPPAETPSSVAPPPAVATVTPPSSPAAVAPATFTGAAVPGFVPQSSTGVAGLVLGALLALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMY6</accession>
    <name>A0A1C1CMY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">K+ channel tetramerization domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMY6"/>
    <dbReference type="STRING" id="86049.A0A1C1CMY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06641"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08802"/>
    <dbReference type="eggNOG" id="ENOG502QRM9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="745"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="852" mass="92405" checksum="0A783414AC543122" modified="2016-11-02" version="1">MTDPHPILDLDRNHVSYSDTTTDTNLDSPAISISSMPDGRRNSTGRAVTAAGPANGPGPAPEATNPPSATANAYTTVSHPYAEPADAANPPPDTRPFFLLEDLEYPTSIVYDLESRHHLAAASTDATSYTLGAPSFGSQPWIAPSGPFLDFAPQPIYEPTGELLRENIHHFDEFDAPSLSRLPAAVSAPAKNPPPPPTRTSADAPSAANGTGAVTAFVPPLLPRSALKRKASSTASTPTDSCVDKKARVPSRPGPDTAVATNRSVTFERMSGVGPTSPDEGSISSELPAGSRAAPGAATGNRRTRQSSGSTPRPSILPSTSSQGSTRGRGTRVSSGHPPSILPPEKVFPIQIGSDLFRLSGASISSDAPSYFTQFFEEQIRQNEESGGVRTLYIDRDPATFRDVARHLQGYYVKPVDGSHFVKLFADAQFYSLPRLIDQLFESEIFIQIGERHFQIPKDIFSEPGNSPNFFSLGFAVFFSTPGEVFPGLDRRGLLRPPSITPPYVPGRSAEIFAELLHLLRGYPLHIRNESHRSELLRDCRYFHLRGLEQKIIAHEISYNLERQKHEICLRLEDVKPSGVSYTRDDSLGEKSTTGGWVYYARPFVDDTSYEMVVEIGPESTVLDLTDMRADLHGLAKARVSSLFQVVANKMNLPTNAPLGLMMLSGGRSSQSASPGHTPLSEDRVKVRFEPATDVTLDGESLEIDWDSPAGQVMQHGPSTVASESESESDVMSEGTAVKPGPSTTGGQQRRPQPRQTPGGVPSHTGVAARVSLPVAPIQTTRLSEPSTKKRKRQNSQEELGEWTIRTGQWRLRVQPNSQDTIRGGFEIVFIGVKIDAYSSERARNARRSFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMZ7</accession>
    <name>A0A1C1CMZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit</fullName>
            <ecNumber evidence="3">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">gpi3</name>
        <name evidence="12" type="ORF">CLCR_07078</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMZ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CMZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07078"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08800"/>
    <dbReference type="eggNOG" id="KOG1111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000053">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="11">
        <location>
            <begin position="42"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="10">
        <location>
            <begin position="212"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT49880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="504" mass="56809" checksum="9646C88817A8A5FF" modified="2016-11-02" version="1">MPYNIAMVSDFFFPQPGGVESHIYQLSTKLIDRGHKVVVITHAYQGRTGVHYLTNGLKVYHVPFLVIYRETTMPTVFSFFPIFRNIVIREEIQIVHGHASLSSFCHEAILHARTMGLRTVFTDHSLFGFADAGSILTNKLLKFALSDVDHAICVSHTCKENTVLRASLDPLMVSVIPNAVVAENFQPKSYVPNSRNEMDYLRPRPLPQRLGPGDTIVIVVISRLFYNKGTDLLIAAIPRILAAHPNVRFIIAGSGPKAIDLEQMLERRMLQDKVELLGPVRHEEVRDVMVRGHIYLHPSLTEAFGTVIVEAASCGLYVVCTRVGGIPEVLPAHMTTFAKPEEDDLVLATGKAIAALRSGKVKTERFHDQVKMMYSWTDVAQRTERVYDGITGAISEQEFYGEHANAPWSASRVRGYALIDRLKRYYGCGIWAGKLFCLCVVIDYLIFLVLELWAPRSRIDIARSWPRKPFINDKNKPVENGAYRRRGTDLMDRRNGSLVMREAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPC4</accession>
    <name>A0A1C1CPC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPC4"/>
    <dbReference type="STRING" id="86049.A0A1C1CPC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07795"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04039"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="101" mass="11120" checksum="E8F31685F52D4EFA" modified="2016-11-02" version="1">MAGSLTCTTDRRLEQRGFAKSEIVKLLMQWYKAAIFCLNQAEWTMIHSIYSVQAITTLTMSAHPLGGSSELSVLLGAALKIAQSHEWPKVLHLPCGSAMDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPJ8</accession>
    <name>A0A1C1CPJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-arabinitol 2-dehydrogenase [ribulose-forming]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ARDH</name>
        <name evidence="5" type="ORF">CLCR_07228</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPJ8"/>
    <dbReference type="STRING" id="86049.A0A1C1CPJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07228"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05582"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT50419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="372" mass="40149" checksum="4CA4B9A1D711BCDA" modified="2016-11-02" version="1">MNTSTTHRLLRQASRRLANLPRTPTATGFRPLSTASPRALRLTPWRLDKDDPYHKASTEATGTSAGPHEGSASRTDREIVVEYPPEEEFPQDRPLRGRGGVQYVKTLPTFSLEGRTAVVTGGARGLGLVMGQALVQSGADLAIVDLNKEEGEKQAQELVSLIAKENKESGSDEPVPKVTAHYADVSDPASVNACIADIIGQHGKIDHLVTSAGFTENFSAETYPYERIKKLWGVNVDGTYLFSTAVARHLMERDVTHGSIVMIGSMSGSIVNVPQPQAPYNAAKAAVRHLAASFAVEWAHAHIRVNCISPGYMLTALTRKILDDNPELNKTWTSLIPVGKMGSPEDLQGAVVYLLSDASRYVTGADLRVDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPQ6</accession>
    <name>A0A1C1CPQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07708"/>
    <dbReference type="OrthoDB" id="4134773at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650961" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="14133" checksum="F683D9B809BF3207" modified="2016-11-02" version="1">MKITAIASLLGTGAQLASGAPLAIRALGGTVVIRQSAQSSNAFIDTTVTIDLEGNRNPQALKVLSQRPKSVQAISTTSDAPFVTCDYTCQSRDGTNGDSVTCGSTTMKSGAESATLDVSWVDSVDSVICFVSATDPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQI1</accession>
    <name>A0A1C1CQI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 28 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQI1"/>
    <dbReference type="STRING" id="86049.A0A1C1CQI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06697"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05257"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="63922" checksum="3F1C463CF4E2FB2D" modified="2016-11-02" version="1">MPWSPTREFPQPIANIKSSRASRSMTNEMSYTLVDMLTWEGLGDLVNKFRKETLGLPILSQAAATDMLHRLRIPYTYCWSPALIPKPKDWGPHITIAGFYFLSLASNYQPEPALAEFLAAGPPPVYIGFGSIVVDDPNGMTELIFDAVRKTGQRALVSKGWGGLGGDDLGQPADVFMLGNVPHDWLFQHVSCVVHHGGAGTTAAGIALGRPTELTADRLADAILQALKPETLTRAKELGDLIKEEKGTDVGAASFHAQLDIENLRCALAPSRPAVWTVRTATSKGRTAAADIRLSAFAATVLSNEGLLDVNALTTHRPCEHPSDYGVMSAHALGPNPILSTAGGVASNMIHVPINIAKAWCGLVYEPYKGAKADGLKGFGKGLGRGLGHFLFPQRDMVVGHGAAGVRVAYDAIKRKLGGDSTLSFILATRYVEGFEDVQTSTEEERVAVIARWNELGPPALRATTRRSKSRSRSSAPSGANTPATSASVSPGPSLSRLTSQTSTKSAKSENRLSRLFSRSSAARSTRSEVTLVRDAGAGAGETSTSTSTSTPPPYSHANETGQKEGEGSAEAHEDISTILDVTSLDVISLYGHRTTVPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQV9</accession>
    <name>A0A1C1CQV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative nuclear pore protein (SEH1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_08254</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQV9"/>
    <dbReference type="STRING" id="86049.A0A1C1CQV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08254"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09497"/>
    <dbReference type="eggNOG" id="KOG2445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5566198at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="392"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="522"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT50851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="547" mass="58910" checksum="988F8246EB8FD101" modified="2016-11-02" version="1">MMAQQRRSQRQAVVRVPFVLEHVCLAHWLDNRASQDDNESSSSSESASSSLKSPASNTTTSLPAPLPRRRRQLDEAAMAATKPFDTGHNDRVTVIHSNFNGTKILTGSIDHRIKVWDRDSKTGETTLLDTFTAHDADIKDAKFLSPTLGTHLVTTGNDLKCHLWSEDATQPPLQGHHFRRVATIQSTPRVPFVSLDVKTLTTDHITTFLALIDRLGLLSIYEPSNPDDLREWTLLDTFNVCTPNAAPSRGDETSFKVHFDPNPTPLPYMMSVNDERDQLGLVVCALNEVKIFRGVVPSATGTGTGSSSSGGGGGDGSIGGIGLGIGSGSGVSSTAGASHRIMFYEAINLPVHPALVRDVAWAPFSVRGTDRIATACKDGGVRVFELGVAEGQNATGNNNESGSGGRNGTERHQSAARARNTVQQRQQQQSSLTSAITGRQTQDSSTQMSSQAGGSRTNHDFGYVTTLSSFTTLSQAHTDAWSVTFDGQGQVLLSQGSDGVTKLWRKSVLNGQWMVFAGQDITEDSDESDEDDDEDEEVNEKLGGLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRK9</accession>
    <name>A0A1C1CRK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acylglycerone phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRK9"/>
    <dbReference type="STRING" id="86049.A0A1C1CRK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08676"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09738"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="369" mass="40447" checksum="0C7B17C56EE71D81" modified="2016-11-02" version="1">MASRRTPTTCRRRTVLITGCSVHGLGHALAIAFHNAGLRVFATARTPEKMIGLRERGIECLQLDVLDQGSIQRCVDDVRRLTGEDEDEEGGGGGGGGRLDCLVNNAGGGPFVGVACTRTVVDTSTSAGERERELEKSARPRKFTDANLGYNMPVADISVPEAKALFDLNVWSYIAVTQAFLPLLLHAARKKASSPSLVLNNTSISSIEPTPHNSAYHASKVAAAMFSTHMRIELQPFNVHVVDLKTGCVHSKFHANHQDGKASLPEGSIYAVDEKVKDMTEAAMRGAFPDREDPEVWAKNVVADIMTSWEKKGWLGGSALPLEIWRGTGAWRTWFYNCTFWPVGWWDEGWRKAVGLDLLRERLQGVYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRP6</accession>
    <name>A0A1C1CRP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_09069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRP6"/>
    <dbReference type="STRING" id="86049.A0A1C1CRP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09069"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06923"/>
    <dbReference type="eggNOG" id="KOG4555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="539634at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038906">
        <property type="entry name" value="TTC36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405">
        <property type="entry name" value="CDNA SEQUENCE BC021608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="235" mass="25677" checksum="FD96F554A6B866D0" modified="2016-11-02" version="1">MARGLTKNDSSVLAALFDPESSLTSTVEIDDNIPTSSPSRLKPLQEQELFALNSINHDQPQPNEIKLAVSRLTTIIESDGSYASAWNNRAQARRMLIADEKLSENPASVAEIFEDLAQAILLTTPTQANTALSIMDARTLASAHTHRGYLLLLASKSEEKRKMLASVRGLDELSLQDLEEAASRELAKGGRYGNETARQLAVKTNPYAKLCGSIVREAITKEISDFHHTQIHPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSB1</accession>
    <name>A0A1C1CSB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LEA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_07886</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSB1"/>
    <dbReference type="STRING" id="86049.A0A1C1CSB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07886"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06698"/>
    <dbReference type="eggNOG" id="ENOG502S06V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3937590at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022124">
        <property type="entry name" value="DUF3659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054256">
        <property type="entry name" value="DUF6987"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461:SF1">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12396">
        <property type="entry name" value="DUF3659"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22485">
        <property type="entry name" value="DUF6987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1557"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6987" evidence="3">
        <location>
            <begin position="1411"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="891"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="893"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT51385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1621" mass="170131" checksum="A364A848743CECEC" modified="2016-11-02" version="1">MPSPAAGRATNAPETPTKTGKSPASSSTSKLTGEGGTPGRKPPKLGSSKATPKKLDTPSRPKQEDTPKPTEEKREDEKPEETEEEDQGQISLKDTEEPGGKVSQPGDDTGASELSEANPEPVPDSDEEEDDGETARGGKEAAKDEGTEGEEEEETEAPTEEGTTDAAEEAEDEAEDGGKGALGGVGKAAKSVTGAGKKVAGRVTGAKDTATNGAGKATKGDVQGAAEDTAGDTKEAVEDTAGDVQDSAEDTAEGAKDTAEGAVEDVPKDADDVKETANGAKDQTEKVAGDVEDTAEDAAEDATKDLPVDLAALKGLKVSDTGDIKDKSGRVIGKLEEGDPADLEGYEIGDDGEILDEDGDVVGRANVIADKAKDAAGDATEDADAEGAVNGVKETAEETAEDAQDQAEQEVDGVKEDAEDAAEDVQDQAEDAVETYLPDISVLDGLEVQENGDILDKEGNVLGKITEGDPADLVGMTLNAEGEILDEDGDAVGRAEVVPQPVKQAAEEAAGDLPGLDALEGLEVQEDGAIKDKEGNTLGKITEGDPADLVGRTVNAEGEVLDEDGDVIGRAEVVPEAAEAVKDKAEGGVEDAKPEAVQQALDKVDEVAEQLKPNLTIVEGRKLNKKGKILDDEGEVLAELVEGDLKACQGKIPNENGEIVDKDGNVIGRVQVVEGEAADEAMKELHPDLVEELEDAQKAADEAEKQAQEAGDQADAAGEAKEAAEDAQEGAEGAADEAKDAADKAAKPDFAQLEGLKVNKKGEVVNEDGDAIAKLSEGFDVEAVRGKKINENGEILDKDGNVIGKVEFIPAAVEEGLVETIDEAAPDGLDTSVLEGLKVNKKGLVLNEEGEEIAKLVEGDLAAVAGKKLNDKGEVLDKDGNVIGKVELTTQEQPEEEQADEEAGEEVDDGLPPLSILEGLKVNKSGKIVDSNGNIVGELVEGDAKKLWKAGTVCDAEGQFWDNKGHVIGRAKTLPQEDAEGEAEFAGLEGLTVVADGWVEDENGNRVGRIVEGDAKKLVGRAVDEDGDIIDKRGNVVGHAERYEEPEAEPEPEPEHIDLSELKGLSPNKQGNVIGPDGVPIGRLVEGNPKELAGRKIDGEGQIWNDRGEVVGRVELIPASEREAKPEGPFAGLEGLVVVKEGFVEDHEGNVVGKVIEGDWKKLIGRAVDEDGDIIDKYGNVKGHVEPYEVPEEEVVEEDLSSLAGKTVNKSGKIVDEHGTIFGEVAEGDVKRLVGCKVDGQGQIWSNDGKVIGRGRLIAGGDDGRSEGPFSNFESTSIDKEGYVRDSAGEIIGRVTEGDVKKLVGRKVDDDGDITDKNGNVIGHAERWEPEKKEREVSPMAGLRVNKEGEVRDKNGDVIGRLTEGNLLACIGKEVNDNGYVVDQDGNKIGECTLLENIPEEEVEEEGPTPEQMKEEEEREIAKKISSIINQTLEKMEPICKQITEIIERADRTPKDELDEEKLVQDVKPLIEEGGRILGECNGAIRGLDPDGHIAANAKAKAASGEATPEEHRVAEGLKELTTQVVKTVDNAKKRIADMPHAKKKLNPLWGLLTEPLFQIIAAVGLLLSGVLGLVGKLLNALGLGGLVNGILGGLGVDKLLGGLGLGSVAESLGLGGGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSX9</accession>
    <name>A0A1C1CSX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_08870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSX9"/>
    <dbReference type="STRING" id="86049.A0A1C1CSX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08870"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06496"/>
    <dbReference type="eggNOG" id="KOG4473">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="304" mass="33190" checksum="BEF3E46D1D5C7C32" modified="2016-11-02" version="1">MAREKCGQSIRHAQQSPERETLPTAPDLEANRPLLSRTSTLHEVPEVQGHSEHHKVNETQRRRRWLWSSWTFQLSGRVVSDAILGLSDGLTVPFALTAGLTALGDTRVVILGGIAELIAGAISMGLGGYVGAKSEAESFKATERSCSQLVLHEPETAKDFVREYFEQFGLSAEDTTRVADHIKASAPLFKEFLMQNHFQAAKPDTNRPYLSALTLALSYFVGGFIPLIPYFVVARDDVLAGLWWSIGLMALVLLVFGYVKTGVVRGWTGRDNYRACTAGAGQMLIVGIIAAGAAVCLVRFINAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CSZ0</accession>
    <name>A0A1C1CSZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_09062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CSZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09062"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06487"/>
    <dbReference type="eggNOG" id="ENOG502S3VI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3358048at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="210" mass="23615" checksum="A9A96779F19476CE" modified="2016-11-02" version="1">MDSTRLRKAFKYPSDDDGDGSQEAMDEEEQEHLLQNLQASETSTNEIYTTVFTCLPLVILMPFLWYLSRSTSGTMVLLCLLGITSLISSAYIMYMVPVSTPLGSLSNLPRIASSAQQRRNYSSSQTSFLLTSDQSPINQYLPYLNAFICALLFLASWGYWSRSDVPEGLWLFLLLPGVVFGMVFMAKRSMAEIETGLSELRGMRYQYKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT30</accession>
    <name>A0A1C1CT30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT30"/>
    <dbReference type="STRING" id="86049.A0A1C1CT30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08855"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06455"/>
    <dbReference type="eggNOG" id="ENOG502S6WS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990871">
        <property type="term" value="C:Vma12-Vma22 assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21730">
        <property type="entry name" value="Vma22_CCDC115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT51644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="328" mass="36429" checksum="B4CFC829F6D0D20C" modified="2016-11-02" version="1">MASTLPSPPNSRDSSPDSTSKSNTVADDGEDLSSRLDLLLIEYLSLLDRYTTLRARLGRDFSSGFFALAQANRYADSSLGAGRRYGEEGFDDRMKARRVVGIKRGERIERDRSAPVVELEAAGQTIQHSDKKDLFKRKCKPQLSEVMASDAPKQDSSEPELHEQEYEQGSKDGIDSELPLYAHHLSTETSLFPTKDPLKWYGILVPPALRTCQDHFATAVSSVIPELLNTTFSMRSVEDEIWMIRRELGILDEYEYNPSDIADNPDEEGMKNHSRPSPQDHEPETSVSALELLPSRSKASPAKNSSSLLSTSSGGVSPQPRSRVLKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT57</accession>
    <name>A0A1C1CT57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_08084</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 18">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT57"/>
    <dbReference type="STRING" id="86049.A0A1C1CT57"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08084"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06408"/>
    <dbReference type="eggNOG" id="KOG2534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase X" evidence="15">
        <location>
            <begin position="404"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT51689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="732" mass="81819" checksum="CA9D247A1DD2EAD7" modified="2016-11-02" version="1">MLSAEEKKEKEQFFRDLDRLADLDEDEQEEIILSDSEPPPIRSLTKPAANIPRATLAPSEEVIDERTPLSRKRKQPDDAAQSDQRAARQPRLARSSTLPEQNPDQKGPLIPRLERAATVPERGSIKGGHSKSRTKFTDLSNVQARLKGEGQPKLKKLPKFAAKTKPIDPDKQIFKGLVFSPAVFVPNNDDDSGARIRIHQAIQYGAQWTHEFCEEVTHIIVTNNEFDVSVVAKSFPSNQIPPALLRINWVLESCKSRYLQETHWERFQVPGWKTLHHPVEVAPQIVATAENHAVRIGGPPQANAARQDLERGDSSRNEPDHPNEKSDAEAAADILEVAIRDVRGGADVASAFDLYEDPESGDEDVDRHVGVPTGSDANTATNASNKNAGFLCMESHNGTAEGQNANAQTIEKLQEMATTYESRGDQWRTKAFREAIGKLRRHNQLIRTSQEARKIGLGESIAGQVEEIVLTGRYKRLEYAQDDPRTQVLKLFKGVYGAGEATAYSWIAQGFRTLQDLRKSADLTPNQRIGLEHYDDFQQRIPRKEVEQHAAVVESALKSADPKLQLIIGGSYRRGSKDSGDIDCIITMEGADIVRIRTLMLDTVIPALMDQGFLKVALATGRSSGDDTSKWHGASALPDSDMWRRIDFLFVPWEELGAALIYFTGNDLFNRSIRFLAGKMGMRLNQHGLCKHVMRGPGRQRINDGTLVESHDERKIFQRLGVPYRPPEERNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTF2</accession>
    <name>A0A1C1CTF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">adh</name>
        <name evidence="8" type="ORF">CLCR_08745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTF2"/>
    <dbReference type="STRING" id="86049.A0A1C1CTF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08745"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09475"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="22"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT51770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="374" mass="39838" checksum="1F3FE88A73EC4C3A" modified="2016-11-02" version="1">MESEGQTSVPPSMKAWVLESFGQPYQLHTDYPTPSLTGPHDVLIKVDAASYCHTDAVLAAGTYVNAGSLPLVGCHEFAGTVLRSASGAFKPGDRLGVPGRAYRPCGECAECRLGPAGFQGHGDPVGYSVFCPFSESNGLSKDGGFREYAVVDARQVAPLPEGMSAVEAAPLMCAGITIYQALKRCNLQPGQSVAILGCGGGLGHLGLQFATKMGLRTVGVEASDQAIALAASLGTGAQIVDSRVQDADELAQQFRSSEHARHPRQMGVDAVIVLPESQRAFDYGMRLLRNHGTCVLVSFPRDGFRVSANDVIFRDIAVVGSLIGSNRSLREMLEFAVQHNVRPVVKAFPFDQLNTLVESYHHDDPGKLVLDISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTV3</accession>
    <name>A0A1C1CTV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_08035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTV3"/>
    <dbReference type="STRING" id="86049.A0A1C1CTV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08035"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06196"/>
    <dbReference type="OrthoDB" id="4540681at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT51933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="824" mass="90995" checksum="6041DBD30E206F94" modified="2016-11-02" version="1">MASPLGNEVALRQPFSNTGSQSSSFSQQGSLDWVAFGRIQYSASVAVLGRLAGAGVDTLTVAFGQAMCSAIPLGIHGERVLQDAMKRLSACSTFGDLVWFGVGVRHILRDLVQTTQGSALVALCGALSEGYSSELSALVLHEMSDSVGAPGELRPSFPQWHALSKVTASVFVESTFGLRIRQFMRLSGLPQDCYDDPGHPTDLAQVILAVGRLSSGAVETLYIQGGPACSWVATFADLVLGLRLQLLSCQGDLIFMNYDPALLSPQAIITFILPGIGRSTLRCTGSTAVVRSGGTFISDFFGDHSDNPLRRSGDHAYMFSGGRVEWANMLQDTFGEDFSELLRDSVDLGPDENQRPSSLSVEPKFQKHRSRLFARVLASGTLALLEDTMVCHLHKGHTAFIMWLVERISELRPLTSILLNESVRVRKKAAESRDASFHCYKTDRRRLEGVCGCDNHHCQRIVRTDARRSCLRAIAETVLQLSRILSVSILHGEYRPSRRGLMLIYERAAERSTIYPTNPNLYRPPSDWRKADENVLYLTFSLYSGPRSIPFSNGACAYSDGNVFAYMGTLEKATDSVEEAVLIYVGAGAIQHGPAVYRTVSGLVPYESYQEYPVRHTRPTNGLADLNQDTTSRDLRLYAMVQERFDGLAFWYRASSEYGMITFSPTALVDRLISARRYLQLPSAHYPSAASSPDDSIFGKWEKCTVEGEGIMLEALEGVTGGLVLRPLRENTLGRCVAIARSWAEVFLIKNGEELDVFSQYCAERFASKSAVVRRRNAQRKVRDDESDLEDREWMVGKKMKAMMKATIQVTIQATTTMTIWGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUA2</accession>
    <name>A0A1C1CUA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative HMG box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_08756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUA2"/>
    <dbReference type="STRING" id="86049.A0A1C1CUA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08756"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06048"/>
    <dbReference type="eggNOG" id="ENOG502SA5X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="252"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="252"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT52092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="330" mass="36646" checksum="0D54C7C14823FC9A" modified="2016-11-02" version="1">MTVAMPFSRSLAKQLLARSARSLTRPVSSNPLLRVDGNYVTGNDQSSHAYTLSNIRAPLKLARTYATASAKPAGRPKQHTGRTPAKRTPKSTKVANAGEKPAAKKPKKKTVPKTKPKAAKKKPSKSALLKKARTDHADLKAAALLEEPKQLPSNPYQIILVQETKGSKGNVTNSAAAASNKYKNLALEERERYNHEANQNKSKNEEAYKRWVQSHSALEIRSANNARRLLNRKAKAAGKKKHIKPIHDDRTVHQPRNAYSFFFKERNDSGDLNGMSVAERGKLAGQEWKSLSAAEKKPYEDQAAADKTRYLEEYKTVYGDDPPSVKRQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUJ8</accession>
    <name>A0A1C1CUJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 zinc finger domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_08155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUJ8"/>
    <dbReference type="STRING" id="86049.A0A1C1CUJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08155"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05980"/>
    <dbReference type="eggNOG" id="ENOG502SHBJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14723">
        <property type="entry name" value="ZIP_Ppr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT52175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="694" mass="77151" checksum="EAC5F1C076EE77F1" modified="2016-11-02" version="1">MSECRRSVLSCARCRRRKIKCDRAIPCGQCIAAKSECTGFSSKDQDPNIPRSIVQHLEAEIAKVEGELARNGHLEELNASDILAGMPTNDGVPIDDAALPIIDLPATKPDTPKLSLNTDILATSTAPRDTIRDEVMTCGELQAMIFAILPTGPGITDLISRVRMSLTPSTAIASGSPREARRRSISRANHEVSCAMLKSIPTAILRSLIKKYMTRVYPIYPVLHAPSLWQQLDKVVRTLQELPEKHRAVAPSFDFLIVYLMLSISATLGSARTGHEAKHMVFSGSLFEEGLQHLSDKAKIPSDLAGIQVTLLVLQYASINPRLANVWMLTGAAMRACLELGLHREPPEALQFDQLTLDLRRRLFWCAYNFDRAICSALQRPLSIPDQSIDAHFPSVLDDRHIHPNGIDATGAETKTHNLRWIQFRRLQSAMTEVHFQGKPLEHGQSWEDWLVSMERRLQAWYEDYNDGHELTEFTLAHGLTNLHRPSPRVPLPGPRSLMVAFEAACSSAKSLRDHILTGFYRRSWLIAHHVLENSMVVLFCLRHGFDTISARFNAQQIFEMTKVFTANFLALAAQGWNEVSNYAGVYERLLGPLLESVFSNRPPSLSSFGPAQDAELTRMLYPGPAQLDKLRFGSRSGYEGDGLPTFDVGTLNWEEFSVSDTRSASAEGFVAGWDLFDPNAVSSGAHDLVFGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUP1</accession>
    <name>A0A1C1CUP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein root UVB sensitive/RUS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_08509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08509"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05949"/>
    <dbReference type="eggNOG" id="KOG4249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="6">
        <location>
            <begin position="34"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT52207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="484" mass="53757" checksum="047C76BBE71C6A69" modified="2016-11-02" version="1">MEIRELDAEGQPTVTFRYDPVSMAFEMRPSQRSASTSLMMRLMDVFLPAGYPLSVTADYTPYQIYDTLQAFASTIAGLLASRAVFVGMGVGSEDASVVTTMLLYIAQETIGRLATILFAHHFSQRIEAEVKFYRFFADIVNDLAFILDCLSPGLPVLGRVCTLCVSNACRAVCGVSGGSSKAILSSHFAKSGNIGELNAKDGSQETVISLIGMWAGGLVVSKVHGTWNTWCCLLPLLALHLWANWMAVKSVRLTSLNIERATILFRALLQGQVKDLNVIGKEESILGLAKVLPMRLSTFRVGVSVSDFLHDLPGDYRDQGRKCRHLNRLRQIFQDEDYVLWQDAQTKRGTVLLKESATGETQAKAICHYLRISVPILKDFEPAEPLQYREQSKPAQGLLANGDSEPRFTASHDNNNSVGEFVGGVGEDQDFELISESLRQNRLQWQNLRDQADGAGWDLSLTNLVGGRYHRVRMTDMQFEKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUP4</accession>
    <name>A0A1C1CUP4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleolar protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NOP4</name>
        <name evidence="8" type="ORF">CLCR_08113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUP4"/>
    <dbReference type="STRING" id="86049.A0A1C1CUP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08113"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05938"/>
    <dbReference type="eggNOG" id="KOG0127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="38"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="150"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="329"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="514"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="658"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="554"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="734" mass="81629" checksum="96D4EBD379B36946" modified="2016-11-02" version="1">MAQGSKRRKLSNGSYEATSPKTTEKNQDSEAVAKDQRRSLFVRSLPASVTTERLAEHFSDSLPIKHATVVVDPETKISRGFGFVTLADAEDAQAAVAQFNNSELDGRKIKVELAEARHRDGDVAGRGTVNTTALKLKAEREKSKEDSQAPRLIVRNLPWSIKTSDDLAALFRSYGKVKHAVVPKKSPKVQYGFGIVLLRGKKNAERAITGVNGKEIDGRTLAVDWAVDQETWQEVQKTGQDKPQSKDTEKPTSEGERESAGADGRESEEIDSDEILHPDQSAEDNTDLAQTSDEDSVGDLDAQADEGDLGSEAESAISDDEPSQNRNDTTVFVRNLPYSTDDDALKDHFSAFGPVRYARVVYDQDTERPRGTGFVCFFNVEDAKGCVKNAPRHGAPTEQADKEKKRRGENLKHSILENEASDPSGQYTLEGRVLQVTRALSREDAERRASEASDKRDIRDRDKRRLYLLSEGSITSGSKLYEQLGKAEIDIREASARQRQKLIKSSPNLCLSLTRLSVRNLPRGIGSKELKALAREAVVGFAKDVKEGLRQPLNKEELRRGGSEMQEAERKRKQSGKGIVKQAKVVFEDKEGGKVKEGAGRSRGYGFIEYVSHRNALAGLRWLNGHMVKAKNAGEEREKRLIVEFAIENAQVIQRRAERERKAREEGGNRTRPSDRSHNDGGGKGSKKRKRADKADKESRPQAAEALDPEEKNRAAKRNRIIAKKRQARKMRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CV12</accession>
    <name>A0A1C1CV12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_08416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CV12"/>
    <dbReference type="STRING" id="86049.A0A1C1CV12"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08416"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05857"/>
    <dbReference type="eggNOG" id="ENOG502SPX8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF8">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651061" description="Integral membrane protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT52310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="59083" checksum="56AD82ADB913F219" modified="2016-11-02" version="1">MKTHAATLIILLPSLSRAQHEENGAEDFLSWQDSPNFRGTMDIIWSCLFTVFVCVWTAVHLNVPAPPTTDTTVRLWARRIKWVGNCCMVPEIVLMLAAGQWSFARACWREMRDIIAEQDQGHEMESGLLQSKPAPSPEIEPIGPYFESTSTKIKTEMTRPKLRRSETFEQHKKRESDERWTLRHAFYANMGGFRLRDRTGAVHIITAKHINYLVQGKYIDLPKMTPLEINDRSKSDSLAKFLAIMQVGWLAVQVVARTIQKLETTTLEITTLSFVVCTLGTFVAWYRKPYDVQTFVILEMPDHAIEDIDLKFTRRSDGTERDLLKEYVAGHQTSKVVDENGNLLAPYDRLTIIDDGLPTFTASFTDVYGHLWGRRPYDANRIRNDRLPVMEKPVTLVCAITTVAYAGLHIAAWNIPLATDIEQLLWRVSALAMMGCVFAWFFMDHFEEFLGRRRSKKGQVTGVIVPWWRIPASIVVTIVYSLCRLYVLVESFVALRKMPPSAYQQVDWGRWVPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWM3</accession>
    <name>A0A1C1CWM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">THUMP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_10068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWM3"/>
    <dbReference type="STRING" id="86049.A0A1C1CWM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10068"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04294"/>
    <dbReference type="eggNOG" id="KOG3943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2300.10:FF:000001">
        <property type="entry name" value="THUMP domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651162" evidence="3">
        <location>
            <begin position="22"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="THUMP" evidence="4">
        <location>
            <begin position="291"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT52953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="421" mass="46553" checksum="7EE72A461D0F5A1B" modified="2016-11-02" version="1">MQEMAFKLPAMWLRLCYHAWARLTSVDEALKPGHHGASTQHPTAPHSWISIIMTRPTATSESRSFSTEYGRSRTAIVALERGREREKMNSPGAEGRPSKRAKTDNETTTEGPAPPRSKPGKHQSAAQKAQNPNQSRGRPNNRQRATISASGIHNGDVGILVTSDKGQEKKCLQELSDFLAEFFDQEAHSNAAAMDEGHKETVMEKEVDIEADISAELDSLRPQGPGTDGASQQVSLVTLDIPCVSFVRFPAKSTVDPVEVVRKICLTASNGDPAGLRSRYIRRLTPVSLMRKTLNEGLKTLCSQILPKHFRVESETEDAGNHTESNLRPSQTPCKFAIRPTIRNNNKINRDEVIRTVADSVASLGKHTVDLKGYDKLILVDVYRNVVGMSVVGSEYETLKRFNLAELQATRFGDDDKDEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWY9</accession>
    <name>A0A1C1CWY9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ISU1</name>
        <name evidence="11" type="ORF">CLCR_10801</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWY9"/>
    <dbReference type="STRING" id="86049.A0A1C1CWY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10801"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04368"/>
    <dbReference type="eggNOG" id="KOG3361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="10">
        <location>
            <begin position="46"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT53029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="183" mass="19801" checksum="111D64F3993F568C" modified="2016-11-02" version="1">MSQRALLAIPRALRTSAQMSALRPSLASPSSTIRPAAAGLQQRRSYHEKVLDHYSNPRNVGSMDKKALDVGTGLVGAPACGDVMKLQIKVDPETQTIADVKFKTFGCGSAIASSSYLTELVRGMTLEQAGKIRNTEIAKELCLPPVKLHCSMLAEDAIKSAIGDYYKKSKPTRRKLAILKDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXK5</accession>
    <name>A0A1C1CXK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">High-affinity glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HGT1</name>
        <name evidence="10" type="ORF">CLCR_10029</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10029"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00169"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="9"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT53206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="483" mass="52917" checksum="C658D214056B87BD" modified="2016-11-02" version="1">MGKANSIFCSVFLAMGGFLFGFDLGIITSTIAQPHFLDHFGGSISDSESGGIVSAITGGAIVGAAAVYWLGDFLGRRWTIFTGSVISVFGCALQAGTTTIAMMIAGRFIAGIALGLLTSTIPMYCAELSEKSVRGAMSGLLQWMLSWGFLCAQWIGYGCSFVNGDFQWRFPLAFQCIPGLILAVGCLFLPESPRWLCEKNRNEDGKAVLQKLRSGLPQETIELEYREIVDVIAADRANLEINWKTIITRPSWRRRLLLGCGVQFFCQLSGINVINYYGPRIYEALGIGTQTSLMIIGISGALSIVYATIGLWLLERIGRIRPLIVSAIGMAACLATNAALSQHFNPDNHNMLRAMVAMNFCVSLFFTMTGIISWVYPAEIFPVQIRAKGNAASTFINWSFNLVFAQVSPLALSAVSFKYLYVFFCTNLISAVCYFFFYPETKGKTLEQMDEVFGDQIVPHALEDPEGAELAKARLSVVELEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY28</accession>
    <name>A0A1C1CY28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AVL9/DENND6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY28"/>
    <dbReference type="STRING" id="86049.A0A1C1CY28"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10899"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00370"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AVL9/DENND6" evidence="1">
        <location>
            <begin position="7"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="144" mass="16031" checksum="0EF6BD12CF7CB52D" modified="2016-11-02" version="1">MTTIPPQVAVVDFHHARGPEVEFWINEDGRTLSKRNDWSLLPFMALSDGAHAMAEEFSYFTLLDKRDTAAADDTHSHAASSRPTSLFGISCTRQIRSERLKRRSVDVTRSTVQKAVVVVSPTARGMGELRERLGAVTAAWFAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CY45</accession>
    <name>A0A1C1CY45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone complex subunit 4</fullName>
            <ecNumber evidence="3">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyphosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">SPX-dependent polyphosphate polymerase VTC subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Vacuolar membrane polyphosphate polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">vtc4</name>
        <name evidence="18" type="ORF">CLCR_09612</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19574"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the VTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CY45"/>
    <dbReference type="STRING" id="86049.A0A1C1CY45"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09612"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00433"/>
    <dbReference type="eggNOG" id="KOG1161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000001">
        <property type="entry name" value="Vacuolar transporter chaperone 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="778"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="17">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="513"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="570"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCT53467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="814" mass="93491" checksum="29A729916298DCBF" modified="2016-11-02" version="1">MKFGLQLKQSLIKDYYWHYIGYDDLKSALKKPFINGKSGEREPWTDDDEANFIRLLEAELDKVYTFQKLKSQEIVSRIRTAESEVKDVIDRKERQNQAGADTDDDLENDFDLLEADLSDIIADVHDLAKFTQLNYTGFQKIIKKHDKQTQLILRPSFATRLKAKPFFQDNYDAFIVNLSKLYDLVRTRGSPVKGDSAAGGAQQNFVRQTTKYWVHPDNITELKLIILKHLPVLVFNPNKEFEEKDSAISSIYYDNPETWELYMGRLKKTEGAEAIRLRWYGGMENETIFVERKTHREDWTGEKSVKARFTLKEKNVNAFLAGRMTVEEVFAKMRKEGKKSVKEIEDLEQLAREIQYRVISRRLVPVCRSFYHRTAFQLPGDARVRISLDTELTMVREDNLDGRQRSGKNWRRMDIGIDWPFPQLPREDVELFPYAVLEVKLQTQAGQEPPQWIRDLTASHLVEAVPKFSKFIHGTATMFPNRIDLLPFWFPQMDVDIRKPITHRFGIERPANTASYSTSDVDDDDEYDSDDAMAADTQTTGKTTPMVNGSQTDDDEGTRRLKAARQILAEHSRAQDRDELDDANAAPGNSLDEEERVAALPVQDDEYLYDSEADDVEDELEEARHSNSWKYYPLLVKHHAQLAADHFLNFFQKIPTTTPLPQNGSVAGGGNQMTGSVQVKRFKAPKGKRIHVPVRVEPKVYFAAERTFLSWLEFSIIIGSIAATLLNFGDYVSLISAWGFTIVACAALIYSVVIYWLRVQMIRKRRASVSRYYDKYGTTGLCIGLLAATAVSFFFRIKEDGWFQKQGVGVVSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYD9</accession>
    <name>A0A1C1CYD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYD9"/>
    <dbReference type="STRING" id="86049.A0A1C1CYD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10794"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00514"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF1">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="1">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="226" mass="23840" checksum="055A4090553409C2" modified="2016-11-02" version="1">MASATQPPAIPPTMRAWVRRRRGPARSVLELATGLRTPAVPPRSSSDVLIRVSHVSLQFTTEMVMKTVPNLPFTGPWIPEIELSGEVVVAGEGAPAEVREPGTHVVAFQSVPWRLLAGHGVLAEYVRLPGSQVARIDSSLDMASASGIICSGSTALKMIRTAGVREGHTVLVNGASGSIGSVLVQLCKLRGAKVVGVASGGNEAMVRGMGVDEVWQRFIPVGLHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYK2</accession>
    <name>A0A1C1CYK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo shadow domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_11053</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYK2"/>
    <dbReference type="STRING" id="86049.A0A1C1CYK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11053"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00572"/>
    <dbReference type="eggNOG" id="KOG1911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo shadow" evidence="5">
        <location>
            <begin position="41"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT53619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="106" mass="12649" checksum="E0021475976E0154" modified="2016-11-02" version="1">MKRGKSKQSLRETASSEDLPASKRQKRNGARDIKETEPDLSWLPKGDHWEDQVAKVETIERDEETRQLLAYILFKNGKRSKISMDMVYKYCPRPMLRFYEEHLKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYS6</accession>
    <name>A0A1C1CYS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">50S ribosomal protein L7/L12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplL</name>
        <name evidence="6" type="ORF">CLCR_11060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYS6"/>
    <dbReference type="STRING" id="86049.A0A1C1CYS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11060"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00545"/>
    <dbReference type="eggNOG" id="KOG1715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="5">
        <location>
            <begin position="37"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT53588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="104" mass="10528" checksum="D6C22CBB8DC86883" modified="2016-11-02" version="1">MAFAAPAAASAAGSAAAPAAEAEPEEAAPAPAEKTMFTLKLESFDAAAKPKVIKEVKGLLGLSLVDSKKFVESAPKQMKEGVPKEEAEKIVAAMKALGAVVSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYT3</accession>
    <name>A0A1C1CYT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_10880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10880"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT53611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="165" mass="17891" checksum="CDCD32FD09A353B2" modified="2016-11-02" version="1">MASISAPASYTGQVDGTEIRATQCGRSRSTEYDYVLTPPVSAATTAHGRVDSGIEFNNAYLWYAFNRRPGLQQANEEPDEWEFFSSGPRHISILLGGHPGKGKCDTQPSKLTLQRMRVSNAPDMQPQLDCWAQAASGFGLDYSVTAAGSVSGYPVNVWGGALWQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ22</accession>
    <name>A0A1C1CZ22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ22"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ22"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10039"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00632"/>
    <dbReference type="eggNOG" id="ENOG502RYMZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="96"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT53688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="523" mass="59441" checksum="35656E2936E63A42" modified="2016-11-02" version="1">MSSTSSSGDSSRSSSDEPQLGLLDEKRELDHNGSTVGTSTWVKPQYPRQLWNFGLCFSLRHLGRLLGQLLSLLVPSFLHRRSPNEQGKTDKLAPTAFLDGMRGLAAFAVFICHLTYGTFDIVHAWGAAPDPGTQPPTAFTEPLRLPIIRLLYSGPPMVAIFFVISGYALSYKPVKQMRSRQYEQLMTTMTSSIFRRGLRLFLPCFASTFIVICLAQLNLYRLTEDFSNQMRMVLESHCYTQPNMWLQFTDWLVQMLIFVDVFNWSLFAGSIELDRHLWTIPVEFRCSMALFLTHMLTARMSSRLRIMTFAGLIIWGVSWDRWELAPFWAGAVIAELDIICTSTAASGLPSTLTDSQRHLPRRSTRILYWAAFLMSLFLLSFPDVAANATPGFVTLDSLIPHNFTEKHRFWPTIGAVLIVWSSCRLGVLRNRAFCWAPVQYLGKISFPLYVMHGPVIHTLGYLILPRTPEVETPEVMRQFQRDFAKAAIVIILTVIWVADVFLRAVDTPCVNLARRLEKAFFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ78</accession>
    <name>A0A1C1CZ78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ78"/>
    <dbReference type="STRING" id="86049.A0A1C1CZ78"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10872"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="166" mass="19717" checksum="2734BD30108C5504" modified="2016-11-02" version="1">MASYRPRGGHSSQPQGYRPYQASQRDDFYDDRSRSRSPDRRQSSSHRRSPPHDISRTQPGPSQGEFHIRGRARSSDRRLETSYERRNRYYDEEPSRSYDDRHSPSPPPRGRRYYDRDQPRSPRTYRSRSRSRRHSSSEERPPSRGKPSKEVMMEGLAPHLTENDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZW4</accession>
    <name>A0A1C1CZW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_10121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZW4"/>
    <dbReference type="STRING" id="86049.A0A1C1CZW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10121"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00891"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF11">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER (HXT8), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT53986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="264" mass="28907" checksum="A534D12B77A38FF8" modified="2016-11-02" version="1">MTSLTGVNVIQYYQTLNSEPWTAKGWTIANSDPPAILFKSLGINSHMILALAAIYGTLAFLSNVLTTRFLADQWGRRKMILAGLSAVIVIEIYAAVMQREFQNTDNKTGKGFAVLGIYLFVVAYYGMLNSTTWLYGAEVLPINLRSKVMGLAAASHFIVNVGITEAGPSAFANIHENYYYVFVACSFFFLIVAYFFFPHEPISSLTDPVLLLRETKKKTLEEIAAAFGDKVVLLDENDVATESAVMGDKLGALQVESAVASSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZY2</accession>
    <name>A0A1C1CZY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S acidic ribosomal protein P2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_00214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZY2"/>
    <dbReference type="STRING" id="86049.A0A1C1CZY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00214"/>
    <dbReference type="eggNOG" id="KOG3449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT54119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="115" mass="11626" checksum="453FBBE463937770" modified="2016-11-02" version="1">MKHLAAYLLLGLAGNNEPTANDIKEVLSSVGIDADDERLDKLLEELKGKDINELIAEGSTKLASVPSGGAGGAAAAPAAGGAAAGGAAAAEEEKPAEKEEEKEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D070</accession>
    <name>A0A1C1D070_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_00159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000006">
        <property type="protein sequence ID" value="OCT54128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D070"/>
    <dbReference type="STRING" id="86049.A0A1C1D070"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00159"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02570"/>
    <dbReference type="eggNOG" id="ENOG502S0D7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT54128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="796" mass="87900" checksum="CEF1BD60AFDAFB1A" modified="2016-11-02" version="1">MPDGQSRRPSEAEAQGQDPATPPQPSYKRRRIALACTSCRNRKSRCNGARPACSLCVELGFECVYQQPAAGTVKPVQPTSDYDERLRAIEETLRLLVNQKVTFAGEGERPVQSSPDQNSSPRRVATSLHPPRQASNDDEDVAILDEGDLVQPNAEDSVDGMAAITDPEETESRFFGPSSNIALLRHISDATSATLRAIGQSRHSENEVNQSIVSRVASPVTTTLSETSPIARQHINVRSLPAEARAQHLIKLFFSDTGMLFPYIHEQDILRTYSTARQNRFTAVSRSWLCLVNVIFAFATYISARPDQSAEKNAAESEIFIERAQALSAEIEMKTASLETVQCLLLMAQYRQGTQRSDQAWNLHGLAVRAAIQLGLHSRTASAGLSPVEAEIRKRTWFGCMILDRTLSMTFGRPCMMPNCIVKLDLPVNQNLEKLTMLGGSLAAPSRLDPPDTVCFFTATIQLYYVLGDIISELYADNVDVDAGLAIPTIVERTVVLEQKLAAWKHKLLPQLLRRPWDTLDPEGVSVSTWDPVFDRLSVILTLRYLNTRILLHRPILSAFLRQRSGPRTAESLAREDPFFNDLGDRSVRICQQSAMEIVDIVYKTSKPPALLGAWWFTAYYTFNAALVIFSCILLELTSHHSETLHGSYMIALQSPDPTKFVEMIIRLRRAMEALKRFGEGTKSAKRIRKTLLKLMQICMTLVQSNPELGPVALSALATSQQGESAQSTGQSGAQVQPQGVVDGSAAINGVVQNLGPDDPFAFYDMGMQPYWADNSLDLFADLVGVEPGLTAMMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D156</accession>
    <name>A0A1C1D156_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D156"/>
    <dbReference type="STRING" id="86049.A0A1C1D156"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03224"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04707"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="77" mass="8699" checksum="2D00D09D3F58ACBA" modified="2016-11-02" version="1">MLVLYATFTSPHPGLSSLVQEDVLRRLHDRTVRILRESEAISPVLAKDLKILEHVRRQVFPPSNYPPGSTASSFSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D158</accession>
    <name>A0A1C1D158_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">tif11</name>
        <name evidence="12" type="ORF">CLCR_03134</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D158"/>
    <dbReference type="STRING" id="86049.A0A1C1D158"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03134"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04702"/>
    <dbReference type="eggNOG" id="KOG3403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="11">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT54593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="149" mass="17078" checksum="BEEF7C82889A5450" modified="2016-11-02" version="1">MPKNKGKGGKNRRRGKNENDNEKRELTFKEEGQEYAQVLKMLGNGRLEALCFDGEKRLAHIRGKLRKKVWINQGDIILLSLRDYQDEKGDVILKYSADEARSLKAYGELPESAKINETDTYGHEGVDDNVEFDEDRDSDSDKDVDIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1A8</accession>
    <name>A0A1C1D1A8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative methyltransferase BUD23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BUD23</name>
        <name evidence="12" type="ORF">CLCR_00926</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1A8"/>
    <dbReference type="STRING" id="86049.A0A1C1D1A8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00926"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01749"/>
    <dbReference type="eggNOG" id="KOG1541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="10">
        <location>
            <begin position="52"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="11">
        <location>
            <begin position="203"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT54491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="275" mass="29760" checksum="88F54BF6AD13C878" modified="2016-11-02" version="1">MSRPEDLLPPDLYYDDTASAKYTTSSRIQAIQSSMTHRALDLLDLPSPSLVLDIGCGSGLSGEILSEEGHIWVGMDISPSMLDIALQREDVEGDLFLADMGQGVPFRAGSFDAAVSISAVQWLCNAESSGVSPEGRLRRFFDGLYASLKRGGRAVLQFYPKNEAQRNMISQAAVRAGFGAGILEDDGGTKNVKTYLVLSVGGGDITERVRGMDGVDVEDGRRIREAKMAMKGKASAGDAKGSKAWVLRKKEKMRGKGKAVKMDSKYTGRKRGPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1I0</accession>
    <name>A0A1C1D1I0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_01015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1I0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01015"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10119"/>
    <dbReference type="OrthoDB" id="4158067at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="88" mass="9873" checksum="AC9C876D7A36D75D" modified="2016-11-02" version="1">MSSRSHAADDMLSTYLYATRSVADRLLDGNGRVLRSDKNKASMSRVMACPWRTPEKGNNVVVTRLEKEMDKITDPVLLNDAKAYQRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1T2</accession>
    <name>A0A1C1D1T2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1T2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02783"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04754"/>
    <dbReference type="eggNOG" id="ENOG502SHTF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3540210at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="771" mass="86226" checksum="17F541A114076971" modified="2016-11-02" version="1">MADALDPVVNVHEGVWTNYSRGKVWGLTWTLCPTHAVIMTNALAILVTVCGVQLFNIIRYTIYRFGTSTRPETPHLQKQQNILKVAVSDMATAQSMLSLAWKHRRSSGKRSIRAYTIGLFAVLYTVLFWVAGIFSNKAISTSSTSGPWEVLSRSKGCGIWNQTYYDQISSLDISTEDNFDMLVQFKSKKGQDVQLSLEYAQKCYFAQSSAPNMSSTCKTFKTPSLSTSCENGTCPFPSYLCHDNSKTAVLDTGYLDSHHDLGINAKPQDRLRYRRVTTCTVINDTNYVTGWNDKVVNTSSAQVSPATAYANFGPSNYKYTNWTYSYSNFASFFDMFSSQVILPYQLDPEMAYAPTDPQYSVSDFEPIEGLAPIKADLVLLFLSYTGMYTTQVDDPWFAAHEEALFEGPYPYLQSRFARDKPISTLGCTEQHDFCTSNGTCTGLGGFDQVQNVAAFNRALTRHQNVTFDRLLRATSLASLQQITMNLGLTTNPLLASNATYTGSSGAVLSAPLPENQWKLELEYWHSIAMAHLQRTAFEWATGQIAPTPQRVQYLVPPQEEPDIWFCNSMILKSAAYQSFNLVAIILIVIFGTLIIIFGLNKENFTVLLSKYPRRPKSEQSWGDDDMLDLGSPWGPRTLPRQHRQHDRSSPDSPSTEPELIKKTQVPSIRRVSSPTLPPEDRTMPKLDRPLGTVDSGIGKEMQRPPRPPRSSWIAISPSRFDGLSPEIPGQVPNNNEVRPTRRPLNGPPPTTLVSDTPPSNRPLSRYLGPWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1Y1</accession>
    <name>A0A1C1D1Y1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_03187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1Y1"/>
    <dbReference type="STRING" id="86049.A0A1C1D1Y1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03187"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02860"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic-ring-hydroxylating dioxygenase alpha subunit C-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="128" mass="14460" checksum="3668ADE8DC31624F" modified="2016-11-02" version="1">MRVVPVSASRVSMQYEVYRHVGSSDQDFEALDRFFKQVEAEDKYLCTNAQKNLNAGGYVTGPLHPQREKGVLHFKSLIKRLLVDHGEKEKSLGREITPAKRSPDDAAIAEEELFCQDMCSRAGEDSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D258</accession>
    <name>A0A1C1D258_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LETM1 domain-containing protein YLH47, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">YLH47</name>
        <name evidence="10" type="ORF">CLCR_02848</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D258"/>
    <dbReference type="STRING" id="86049.A0A1C1D258"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02848"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04968"/>
    <dbReference type="eggNOG" id="KOG1043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Letm1 RBD" evidence="9">
        <location>
            <begin position="260"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="487"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="501"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT54877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="568" mass="62966" checksum="15FCA972C456B908" modified="2016-11-02" version="1">MSSGPRIISNAAARRLLIQSYSRVVHSSSLTGYAPRSRFARDLPPKLSALAIALPQRNYATETTPSGTDSGPPPGFNIDEAKKPLAEGGDKKSASSPTTTPWVAELKKSDEQLHVPKSVATATAKTRAIENASLGELAAEKAASAQTDKQNSAEVVAKKEESKKLTLGQKIKKEIQHYWDGTKLLAAEVKISSKLALKMAAGYELSRRENRQDLGRLVPFSVFVIVPFAELLLPVALKLFPNLLPSTYEGQKSRETKAAHLRETRKQVSSFLRNTLRETGLPVSAINAKKEEFTEFFRKVRATGESPSKEDVIKVCKIFKDDLTLDNLSRPQLVGMCKYMNLNTFGTDAMLRYQIRHRMRQIKRDDKAISFEGVDSLSVPELQMACASRGLRTHGMSPGKLREDLQMWLDLRLKYNIPSTLLVLSNAYMYTSGKDSEIDSQIDALQAVLSSIPEELFHEIELEVHNAEGAATNKQRLEVLKEQQELIEEENEQAESSKQTADAKGEKSAASTPKDDKDIDEKPKPKPADSEKETKKADAKSEAQEAEDDVTEQGKQEQAQKTSEPKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2I1</accession>
    <name>A0A1C1D2I1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_02865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2I1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02865"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05083"/>
    <dbReference type="eggNOG" id="ENOG502QU7M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF16">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008448742" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT54987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="581" mass="63667" checksum="0F4934E8BC6554D8" modified="2016-11-02" version="1">MRFHVPVFAVVLASATAATLNDVCTPSYVRAHLPPPGFYQGVSLDPSSVTANPVSQVSVADSNFFPDATFDYCNVSFTYSHDGLEDQVALTYWLPAPGRFQNRFLATGGGGYAINSGNQSLPGGIIYGAVSGLTDAGFGAAQSNTITQWLDANGTLNWHKVHMFGYQGIREMSELGKAFTKSFFNMTQTNTTLYTYWQGCSEGGREGWSQVQRYEDSFDGAIVGAPAFRWSFQQTQLLYPNVVEQTMDYYPSPCELQKIVNETIINCDPLDGKTDGVVARTDLCYTQYVEAANFSTIAGQPYACPATPATAGSPAIPVQQGNVTKQAVAVAKKILEGLHDSQGRRVYFAPTPGAQMTEAQTGYNATTQQWGLSVISLGGVFVEVEIHLRNGSNLPDLDGVTYDTLKDWITEGMQRFQGVLETTWPDLTPYRDAGGKVLMFHGEADWGIPTASSVRYWESVRKIMNPGQSYNDSAAAQNEFFKLFLVPGATHCAANPAQPDGPFPQTNLAVMIDWVENGIAPQTLNATVLLGEHKGRNQQICAWPLRPVWRGNNATSPECRFDEQSVDYWNYDLDAFKVPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2W4</accession>
    <name>A0A1C1D2W4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">APL4</name>
        <name evidence="13" type="ORF">CLCR_00006</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000001">
        <property type="protein sequence ID" value="OCT55126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2W4"/>
    <dbReference type="STRING" id="86049.A0A1C1D2W4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00006"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00011"/>
    <dbReference type="eggNOG" id="KOG1062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="709"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT55126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="823" mass="90510" checksum="4F1042C51BF933D8" modified="2016-11-02" version="1">MTSLKQFIRNVRASKTIADERAVVQKESAAIRASFREESGDSNIRRNNVAKLLYLFTLGERTHFGQIECLKLLASPRFADKRLGYLGTMLLLDENQEVLTLVTNSLKNDLNHSNQYVVGLALCTLGNIASIEMSRDLFPEVEALISTANPYIRRKAALCAMRICRKVPDLQEHFFEKAKALLQDRNHGVLLCGLTLITSMCEADEAEGGEEGVVDMFRPVVPHLVRTLKSLTSSGYTPEHDVSGITDPFLQVKILRLFRVLGRGDTGISEQINDILAQVATNTESTKNVGNAILYEAVLTILDIEADSGLRVLGVNILGKFLANKDNNIRYVALNTLIKVVAIEPNAVQRHRNTILECLRDPDISIRRRALDLSFTLIREDNVRVLIRELLAFLEVADTEFKPIMTTQIGIAADRYAPNKRWHIDTLLRVVKLAGNHVKEQILSSFIRLIATSPDQQTYAVQKLYAALKADITQEALTLAAVWVIGEYGDALLRGGTYEEEELVKEVKESDIVDLYTTILNSTYANQITTEFIITSAMKLTTRMSDQSQVERIRRLMQSRTADLSVEIQQRAVEYGNLFGYDSIRRGVLEKMPAPEIKEEQRVLGQSAVPAKDKRKSLKAKTNAKVTKTTESDMLLDLMGGSDASAVSASATLNGNQQQTADLLADILGGTSVSSPPPQTKSPAPASNTDSIMDFFGNGTPKPASPVPGAHVAHPAYNKNGLSVTLQVSRTGTAIQAMAKFKNTSTFERMTDVGLQAAVPKSQKLTLQAINKSTLDGGEEATQGMRIAAATGSLPPKLRLRLKISYTKDGGGPVTEQVDWTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D372</accession>
    <name>A0A1C1D372_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mak16</name>
        <name evidence="7" type="ORF">CLCR_03020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D372"/>
    <dbReference type="STRING" id="86049.A0A1C1D372"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03020"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05197"/>
    <dbReference type="eggNOG" id="KOG3064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000001">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT55108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="328" mass="38550" checksum="7F80E9AE8131E2A0" modified="2016-11-02" version="1">MSSDEIVWQVINQQFCSFKLKLSSKEQNFCRNEFNLTGFCNRQSCPLANSRYATVRPDPETGALCLFLKTPERTHLPSKWWEKINLPNNYEKALAAIDDKLQYWPRFYIHKCKQRLTRLTQVRIRQSRILKEETRLGEKNVSRLAPKVRRREETRERKAESAAKVEREIERELMERLTSGAYGDRPINIDEGLWKKVLRGLERKERGDELAEEEELEDEAEEEREAEVEYVSDLDESEDELEREMEDFDDWLDGESPDEADEEADDDDDTEESDGEDKSASSDEEEDIEAGKKRKRVAKQPPKPQKKPRGRVEIEYEMEQPLKEAILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C729</accession>
    <name>A0A1C1C729_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C729"/>
    <dbReference type="STRING" id="86049.A0A1C1C729"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05889"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06958"/>
    <dbReference type="OrthoDB" id="4142959at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="375"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="447" mass="51443" checksum="2330E643A1252CF5" modified="2016-11-02" version="1">MSQNSTLSYAAQERQRLHEARLALVRDFARTIRPSRKDLTRVAEFARSIEGPIASKDLASLSRALSQFAEAKDDIEVTEAFIMNLPEPDDHVPVLNVITRLMDRDEQVHDAVPDFTLRSWAEIPQKRRAIAAEVSKRGLEALDRLPEAIRFEVKRNFSPAIPRWYQYHLIEDIPIQQSNSTHQEPASVTEAARIYWEDCVALRNHFDRIVDCYGEMVDQYPDVVECDAAGRFRDLERMKPAALGDLSRARGVVAGLLLNFDIIGAISEDDVPGIRRRLQQEETHFVLVRQSIHAAEAYLVARESRTLESGDFTFPAYASRWERARIRHTFKQFLQDRIRTLHLKDANYEEDLLKSMETEELPALEIQQGTVDDACCICHDEVDEGDHSLVTSYTCCKQPFHSECLLGWLLEGFNPNTTRECPFCRRYVHPEFVGQVMEVRMRELKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7D4</accession>
    <name>A0A1C1C7D4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative V-type proton ATPase 20 kDa proteolipid subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">vma16</name>
        <name evidence="13" type="ORF">CLCR_06237</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7D4"/>
    <dbReference type="STRING" id="86049.A0A1C1C7D4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06237"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07082"/>
    <dbReference type="eggNOG" id="KOG0233">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="47"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="131"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT44387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="199" mass="20577" checksum="3C58BA76B0386465" modified="2016-11-02" version="1">MSLIYPAGGALGALGVIGLYMLFNGEGEQFNVGQFLETVSPYAWADLGIGLCIGLSVVGAAWGIFITGTSILGGGVKAPRIRTKNLISIIFCEVVAIYGVIMSIVFASKLSMVPEEALYTGSNYYTGYALFWAGLTVGMCNLICGVSVGINGSSAALADAADATMFVKVLVIEIFSSVLGLFGLIIGLLVSSKAAEFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7K9</accession>
    <name>A0A1C1C7K9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha-1,3-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_05553</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7K9"/>
    <dbReference type="STRING" id="86049.A0A1C1C7K9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05553"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07168"/>
    <dbReference type="eggNOG" id="ENOG502RZ48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="505"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT44486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="683" mass="77341" checksum="40BD3C16AA537F34" modified="2016-11-02" version="1">MSSAPTSSIQPQIVPPGENDKGAIPISDPLFHAPQNEAPNQWQQTQPPQQPQRLSPNLASNEHNEGRFEVPPAEAPTQRTDPAGQNLDSAPQRPRGPSKADLEDEPSIASIDDDTAAQPKPYSNNAKGSGLSGSPRFLSNPSSFSERPKFEKALARVISLLPGEMEGRDLLRPVEGTGKEKLREMGLRVREYKKFFEAWENLHLTFDEEGGSYVRDDVIQYLRHHQHQPADDEFGETSLAQTIHSYEAYRYFLVKFGQLLFPWTAPYFPDHMTLHSHFKKGGRGIVLTAGDDQAPFLLTIIPTFRNLGCDLPIEIMYLGDSDLSEDYRSDLESLDGVITRDIAQMVNDEGWKLAGWAAKPFAILYSSFREVIFIDADSLFFVNPATLFEDPAYQKTGALFFRDRLIMPENKKRWLQQILPKPISRQVKQSRMWTGDSGHMQESGVIVVDKWRHFIALLFVTRMNGPDRDGNKDEGRVGVYDMVYGDKETFWLGWELVGDQDYSFHQGDAGTMGTVQEPEPDTPKPKLVKKKRPVLDENGQPRLDESGQEILEDYEVLEDPEPSSPEGDDSDDGDDRHNNRPEPSNYTICSPQLLHLDLEGKPLWFNGWLLDNKFADKKQKKFGKFEHYLIEPRDVRDPGAWQLEESNMCCLTTDAELKRDFTAQEKDVLNMMISQAKEVGVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7S9</accession>
    <name>A0A1C1C7S9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphotransferase</fullName>
            <ecNumber evidence="1">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_06349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7S9"/>
    <dbReference type="STRING" id="86049.A0A1C1C7S9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06349"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07193"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF29">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT44511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="185" mass="20414" checksum="3676E2F248B97933" modified="2016-11-02" version="1">MSELASAQSASNGSPPPDDLEGELDAFVQPLLIDDNVVHNLAYQFSKVYEELAVRSDEQFLPTPVTKLPTGQETGQFLAIDVGGTNLRVAFIELLGDTEELLPTANGVERSRETIRNAQRPRVRRTLEKAWPIGEHLKMDKTEDLFAWIGDCIAEVVGDRLTSDNGKVPVPEELAMGITFSFPMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7Y2</accession>
    <name>A0A1C1C7Y2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_05477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7Y2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05477"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07293"/>
    <dbReference type="eggNOG" id="ENOG502S4AX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3431704at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF28">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT44620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="845" mass="93956" checksum="B9C00E81214BA6A4" modified="2016-11-02" version="1">MSAPEVEAQRGSATSPPNADVGNPPRKRRKRAPAAGAAADCFTCATRSVKCDRRRPYCTQCLDDGKDCAGYKTQLTWGNGVASRGKLRGLSLPIAGTQKLPPPTFSSATKRRPSQQQPPAHLPPLRSPIAPSEARTAPAPLVSPASATGGNHAFLYEQPRPPPLVTSPYPTSTAWVAPTTAATVQLEPRESTYPTPSSANITSPQHGPPLSAGLNPNSVFGGTDRLTPTPYTAPSPESAYLGRVLSHSTSNVSATRPAYPVSPQIHSPFDLVFPDHGQFPPYHRQDESYVRNEAYAHPRTPQQVEPAARHEVSQYADEEVEEVPRNSYEDECAIVEDDSALGFPQLSLNAYNLSLTRFATTGSIGATPRMQFLINYYAEVISPVIVAFDGPSNPYRTQILRLATKSETLQHAIAALAASNLRQRRETGLSTCKTDPARRSSIAHLTLTHEPWHEAGLLSPQEQAREESLHKTVAIQSLNKQLANPVLRKDDSTLATLLILCLFHICDSGVAKFQTQFAGVKKLLSLRKDDPAFNTKEAKWFTRMFTWFDAMTATVNDREGQLQGYHLDVSALSDEEWALENLAGCDGQLFKTIAKLGRLNVLSQGKSVEETSTIVSRPPPPQVSLAPNIDYSKFDGNGWMRLIEDEDLFTTRSAAPDMKAHFWREWREIRQALMTWNLNTTVFDASSPEAPYLSYEQRVDLNNISESFRYSALLYTERLANPSVPSTDPCIRNWVQECLKYINAVKSDVYLLWPLFITGSECVDDDDREVIRQRCLDIQKDSGFLNNKSCLELLEKVWRKYDDKERTSPRGRMANESNYHDNEETGFRFARVMKLENNEGEYIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C850</accession>
    <name>A0A1C1C850_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C850"/>
    <dbReference type="STRING" id="86049.A0A1C1C850"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05414"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07300"/>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="719"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="938"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT44628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1040" mass="112408" checksum="872DEC51108AC43D" modified="2016-11-02" version="1">MSDHGSNESRRSSSQTSHNSADQKKQPKTIRGQPKRHGSKHSSPSIDEDDPALTSFPSFSPELETKSAKSIAQETLRQPLRTISQKARDRKATLAGLTNASPSLNKQNALFDDSPRSSLDIPGSLHLASDEHIERLIARTGAVKLVRQYAADLAQRDAEISALRIRADHRERELKRILRETNVPTAEVEKRLLRLEQGESDPSLGASSIPVDRTPPSLDGMMTEAMADDIVVSSPLDSTFAPVPGTDPRGAAGALQAELEANRSRAGSMASSLARASRTPSRANSSLSESSQDMEATLRPRVSSSNVSKGSALQAIFQPPSNSSSYFIGGKSLNKKPKAADEASVRSNQSNRSFASWTQIFSGKTQTGRSRASSLGQGQNTTAEPETALSKTRTNTALTTNKSSASLPSTGTVKGRPPPKRVPTASRLTPSPSHTRKESNASSPPPTVELDSMIESSQLPPTMTNHSVEATGLLTDRFGFIYDQKRRKRQSLPVRAHRRNKLSANETIASFRSGESPQSGEVLIDRPATPASIDDETPKKSWQDYLKVPAALSSGRPKELLSHTPSAGAVVTVSTADATGTLTPPHRSREASISISATSKKALPSSSVVMEPQSSAVTATSTDFALESESENLADSTSAKLLLEQLTELYDALQSERAARWNDFLRRVRAERANNPDRATNNTPEADLLEGELIGIATLGRSAKTKAKYMHFRSLVLGGIPVSLRPKIWAECSGASALRIPGYYEDLVARSREGTDIDPDIASQIKADVHRTLTDNVFFRHGPGVQRLEELLRAYSLHNPRIGYCQGMNLITASLLLICATAEDCFWLLVAIIDVILPSQYFSSTLLVARADQVVLRHYVAEVLPKLSAKLDELGVELEACTFHWFLSLYTGVLTGGEALYRVWDVILCLNSSDASPYALTQSKPTLGVDLPSLNLSTPSTPVTPAHPPPEPADGSASDEHDGTSSPFLFQLALALLKLNENAILALDSAAQVYTYINHNMTNHAISIDALVQASEGLRTKIVRKEVLEKRKEAMAELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8X5</accession>
    <name>A0A1C1C8X5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_06057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8X5"/>
    <dbReference type="STRING" id="86049.A0A1C1C8X5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06057"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07632"/>
    <dbReference type="eggNOG" id="KOG3332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650648" description="N-acetylglucosaminylphosphatidylinositol deacetylase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT44960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="352" mass="39062" checksum="56717E8EF3B9890D" modified="2016-11-02" version="1">MAFTTILTFTLVPVLVFVLWHLTSTTLPPVPAHLRNKRIILLIAHPDDESMFFSPTLQALTHLSLQNHLKILCMSTGNSEGLGATRRAELEKAAVTLGVRRKEDVFVLDDERFKDGMTQDWKADDISRVLASAFAPHVIGPFTASTAPPSKQSLDSCSDREKEKEKDKDKKKPAKSSPPSSKHTKSSSRTLPSTSPPAPKEPDGPRATIDVLITFDPHGISSHPNHKALYHGAVLFVQKIMRGYSGYACPVSLYVLPSVNILRKYSFILDAVPTLLSGIYASTFGKVLGGGKARGGKDERVVFVNDIVRYWKAREAMVSGHQSQMVWFRWGWIGLGRYMVVNDLRRERVIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9D9</accession>
    <name>A0A1C1C9D9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9D9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06491"/>
    <dbReference type="OrthoDB" id="10563887at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT45130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="78" mass="8141" checksum="6BD4BBFD61735CE6" modified="2016-11-02" version="1">MEVAVSDTEVAVSDTEVAVSDTEVAVSDTEVAVSDTEVAVSDTEVAVSDTEVAVSDTEVAVSEYTIAMTSQYIISAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9M3</accession>
    <name>A0A1C1C9M3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD(+) kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UTR1</name>
        <name evidence="7" type="ORF">CLCR_05831</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9M3"/>
    <dbReference type="STRING" id="86049.A0A1C1C9M3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05831"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07828"/>
    <dbReference type="eggNOG" id="KOG2178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000029">
        <property type="entry name" value="NAD+ kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000008">
        <property type="entry name" value="Putative NAD+ kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF11">
        <property type="entry name" value="KINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT45169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="473" mass="52861" checksum="FB0C46DCDD05175C" modified="2016-11-02" version="1">MSNSNAAPQLSHSIGDRIHDDFHHSGSSSEDEYNRKIEVSFPVSPSDLTSMAEDSSAQVVFDTEGARRRKSSTVLLETPTVDRPKRVTPGRSMSQCLVHKLVEKSSLGQQPKVESQLEQIDEVDPEAKSGQNDGDSSKDLVRTTQSRLLTKKQLSDMAISVRTLAKRLGNLKVRLKVRAIFLLTKIYDKSLIVKTREVTRWLLSKDRSVPYIVYVEDSLKENPTFDAEGLVAEDPSIGDRLKYWDTELARRHPHTFDFVITLGGDGTVLYASWLFQRVVPPVLSFALGSLGFLTKFDFENYQHILSQALKDGVSISLRLRFEGTVMRSHKRDDDAEHRDIVEELIGEEADDRNTHKPDRTFEILNDIVVDRGPNPTMSTIELFGDEEHLTTVQADGICVATPTGSTAYNLAAGGSLCHPENPVILVTAICAHTLSFRPIILPDTIVLRLGVPYDARSNSWASFDGRERYNPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9Z5</accession>
    <name>A0A1C1C9Z5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Topisomerase II associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_05479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9Z5"/>
    <dbReference type="STRING" id="86049.A0A1C1C9Z5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05479"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07946"/>
    <dbReference type="eggNOG" id="KOG4592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="485"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT45306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="819" mass="89972" checksum="848BABA6B6A5ABA7" modified="2016-11-02" version="1">MSFFGFDTALPRDKPGSSGRGIFEHTDPFSEVAKARKLQAFQGNEEEVLDFEDTYDGLGDKLEETGDDLNDDTFGGGAEGGVIEGNVGKDFDFFGNTAQVSNAISEEHMRYNLQHPSHHAGAGQPQLARPKKTGYEKYQDPGYIPDIQAKSSAWGSRAPPAAAPKTDNRISTARPAVPASVPAPVPASTLAPAPVSQTPAMMTLEEVEALMLAQSQAQHLPAPFPQAQSSPFPAQHFPQQPPQPFQQMGPPLGMPAHQQPQPPMPGPPGHNRMPSAPRGPQQPLQILQNPNRARHSPQPSLERAQPVQPPVAQGPGALPVITHPQQLMELSEEQRRAYLEEGARRAKRNHKIFLLSRGNGLMTPQDKNFITRIQLQQLVAATGSSTDANPEAALNEDFYYQVYSQIRGAPRQHPTQPLGHFAQTYLFQTGTRMGNRRQQINGDNHMQRMQQQVQRAVEAAKLKPKNKQLIIEGSLGKISFSNAKTPKPLLNIKRPENSDNRPGSAKKGDGVSTSDRKTILRNIEAVYTTLMRLEDHERQAPPPATEGDGDSIQAHLEWRQKQRELVDSLWQGLKVLDPIVPGSLVAHPFIAFLSFAKGKKAIPRVFHQIDQDKPIIILTMVVVHLDQLDVVKDALLAPGASQPPPIVREEIELFSQTVMPCLLSCVTEAPINIVTGLLGLLIDRTNVSVVAHTKIGLGMMTMLLTRAELVKEAGSVTDEDWQQWTMLYDRLFDILEPLLATLFPGPVNSGDDMYVWQFLAAIGICASPEQQQRLVIGVKDRVMETVLQSKTLPPEMAGARLGNVNLFMRAIGLDVEMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA55</accession>
    <name>A0A1C1CA55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="4 16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">tel1</name>
        <name evidence="21" type="ORF">CLCR_05334</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Chromosome</location>
            <location evidence="16">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 16"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="86049.A0A1C1CA55"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05334"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07962"/>
    <dbReference type="eggNOG" id="KOG0892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 16 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="16" id="KW-0779">Telomere</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="19">
        <location>
            <begin position="1820"/>
            <end position="2422"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="18">
        <location>
            <begin position="2531"/>
            <end position="2840"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="20">
        <location>
            <begin position="2874"/>
            <end position="2906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2815"/>
            <end position="2834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="2817"/>
            <end position="2834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OCT45322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="2906" mass="322300" checksum="359373D0ABF21842" modified="2016-11-02" version="1">MVTQALVKPYLADASALDLKRVLGERANAPEVDALKDDVFHKIFELLYRIVSKEKPVFLRSTTAERTRSLAASRLQVTAAALRLTLEVGTSKLKYKTALSILDHIVDTLPLTDGSLCEPLKNDYIKSFRVLLNYPPHGEHMRPKQWQTYVDFALDCLSTVLEHDVAEDGLPDSRNTSMASRNDRSLSIRPSQRSGKSIGKEKATLAEEIVAALKSLTSVPNVRIMARGPSIAEKIQEYLSVAGTGQEDAFETLNNIMLVSLGQNVDFTQNLLCALIPVMRRLWSSRSGTLREQMLITLYTCRHLFIAPPGPWNPIEADVLEPLLTTMMSDHGKRDLLHFDDMQPLFDSDTAPLKIRQFKPPRSSPRALSCWLTIEIIAGLVVGLSRKGRPSTADSDSGDIPRKRRKIQNHLQAVLELAAVGFGQEKVAALQIVLFLFDQPGALEQDWIQSLDNLLPDLNNEDPTVQTWVFLIFSRLAQTPHPPSQTSDIWLRVWDAARRAMAVVPTARASCHLLTVLLKSGVLDTVMSANLLDGTLFGGGSNGPSSLTDTSLVLMTTILGSKFLDSEKHFESLCLKVLGWLNLRWTLPANLDRLHNAHIVSHARPELLYCVLSSICGFSDPIIAIDDWSPAHSSFKAATMAAVNLDFLQYLLRVPSLSPGTAGPANAMSRPLDMAIRARLFGAVTDFLAAQSREFLLSWKAISAERSSNIGSDIVEMVAVASTVSSAVFARCAGYESEFMPPSVLAETRRIVGDFISSQKNVASCQEMAKRVCACVVATHSQLSRSGNRNFGDDYQGVLEFASNVAHRGLATSMAEDGSDLEFLDEEHLDSQASQSSQAGSGAAVMRFDLPLCHDTHELLAKYAVELTTALQMVKSQALLDSSAATVVFDELVNLDPVSLIGARGAVGDFLSLGVGTSRADAYRLVDKIGKVFLQEEAFERCESALCLCLDVLRHLVDLWSSDEDDDLAEASFEVYDWFLNIALNKGIASPRVSSALADLLDSLMLKNASYGADDLPSPRTSLLEILEVSDPPNQHRMAAKLSHIFDNYVLTQHDAIFEDIVGKLPSDPGRKEGIAARLYIVSHLGARWHTVLRQATYHVFETVAHVPATTKLAQDCINQTCKLLNLRHPRLLFKLFAPQIFFTWLSTESLSSMPFQPFGYTSLQELAEDNIAELTGQTALRGMAQAEDLAQLVGVNWTELLAENFASAEAYTLASETSVPKQERLYDGSEKLVRKRLGSEVYLQRLRECLPDIIVVLLTSLQDDRGIDKALPSPNLAFWQEMVDLAGHRSELPLSQQPCFRARCLPEELNYLLSRLDMQQQDIWTPALLVHLFRRLLDKARPALGPLHTCSIIRKIRIVISLAGAAALEGYPLEMMLHSLRPYLTLFECAGDAMGIYHFLLRRGAPYLSTRPSFIAGLGVAIFASLTGFITSSQDSTTQESHFLATMTKAQEFRMFLTQCLESLHLVNITDDAEHTFMQVIQHARAITQPGTSVKSTNEGQLLYDLLMDQSSKHPLLSSLHFELSITILCQQFSSPPDQQDDILANDEDASRVFPVLESLLRNLELDRPFRIWAAQVMGRGFVMRGLSSGGNKKSRQMQVAIPMSKEGFPGFEAVSSYTSIVRHLTNLLWTSDYPATSFAENTLQLIFSTISHSGERGLLDPDFDRTIVQDMSFTNCPCPTTLLARALSASDIKREGSHDPRLQAQHWAADLLAQISDAAAGDPVLNVLKPLINAIPESAEALLPQSVHLILLSEFDSRQAFREKLSEMFSDILSSAVQQPSPACPLVLKTLLYLRKCQLPRETNMAQRNSWLEVDLHHAAMAASACQMWHEALLFLELHQSQARLQTGRSSRKSLVMTEGIPIEIISKIYDNVDDPDFFYGKHQTYDLQSVISKLGHEGASQKSLSFRSAMLDSQLRVNEQTAALGSVALATASSLSAANMQGISEAVRQHYDVSQKGACADSGSAQDRWDLLPPSESTSSSVGLLSLFRGMHNISNKDSFLMELDRLLLDVGVAIKAVSGSRSHSHRLYSNLAVLAEARQTLGATSMDGLESACAALAARNKNLRHARFDALSPLLAGREAAFAAVRRNERLQSSFLVSLHQALLLEFRVTRQSLEVASSYDEPQFCLNRAMYLSELNHLAQRVGLQVDVATNYDLARTLWEQEEASASIGILEDLRSRKDIAKQAIAVTRADILTDLGHKIAEARLEKPDEIIERYLAPAIQELHARTGSAAGRVFHNFAAFCDMQLQDTDNLDDFTRITKIRERKTQEVYELERMVKNSKTEQQKQKLKSHWARARNWLKLDEEEWRRVSENRENLILQCLENYLLSMRASDDHPNDTLRFVALWLNQAESPTANAAVQKNLSSVPTIKFAPLINQLTSRLLDFRDNFQKLLEDLMFRICSDHPFHSLYQVFATSKSRPPTGDDIAASRWTAANRLTERIRRQSTSSAIWTAVHNTCVALNKVAVEPLPEKHGKSDPKKLQLRRLQGGPGLEAQITKPTSKIPPPTMNIALRADRDYSQVPTSVSISPELSVASGVSAPKIATIIASDGSRHKLLLKGGNDDLRQDAIMEQVFEQVSNLLKEHRSTRQRDLGIRTYKVVPLTKNSGVIEFVQNTIPLNEYLLPAHARYYPKDYKSNKARKDIADAQGKTAEQRVRAYHTVAANFHPVMRFFFMEKFLDPDDWFYKRLNYSRSTAAISILGHVLGLGDRHGHNILLDEMTGEVVHIDLGVAFEAGRVLPVPEVVPFRLTRDLVDGMGLTGVEGVFRRCCNFTLEALRRDQEAIMTILDVLRYDPLYSWSVSPLRLQRMQENNGQAPAADGAAGGTAATSVSSTSLTNDATAFGVIAARREETEPSEADRALTVVAKKLGKALSVEATVNELIRQATDERNLALLYCGWAAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAF0</accession>
    <name>A0A1C1CAF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_05540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAF0"/>
    <dbReference type="STRING" id="86049.A0A1C1CAF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05540"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08077"/>
    <dbReference type="eggNOG" id="ENOG502RHAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4115221at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="299"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="721" mass="81012" checksum="02662D0162E5C97D" modified="2016-11-02" version="1">MALAGSEPMARVGGLSKRAPRACESCRARKVRLDSKTCVLPASRRRHVGDRILGSSFLEGNQHNPQSPICDAIIDFGDTKPVRLHNHIEKTHAPPRDGSFDVFDLAESPLSINDKAVGVGCPTKDNAINSKAYYPASLLTPYPSPTQSLLDCPLGHWMLPNYITPIPRSISGEDLQYLNNKGAFDIPDTQLRDQLLEAYARWIHPFAPMLDLEQILTAIFTNGERGTLSLLLFQSILFAASAYVHTDYQQGNRKRLRKTFYERARLLHDFDAETDRLSLCQAAILLSLWDGQPGSVRDSYHWIGIATLHATSLGLNVTPPENLVETRRQRTLNKTWWTLLVRDRLLAVAMRRPVQNKVFRFDAPMLHLLDFRPEPLVEVLRKTLHLKDVTVRHMETLVSLWMALAQLSEYIDKVLNLQYTSQRASALSGQGSAVMSLVPQMDVSKSSEIRACGLELQNWYGYLPKEVQLLDVASSRPDDIETIRVHRQLLAGYYSMTLMTLYRPLLNLQSTVPSEATLCRESMKIVSQAAASITDIFKDLYADNLISRLPDTAIAVLEPAVATHLLCSMSVTPTVRDSSFQKFYLCWRILLQFKQTYHLADMTMSMLDAAAKRLKSPSDLKALKKAAFSQLMDELASADEEAARTYMAVPFLGVVGEQKTNRSDVVNDWPRQSRPRREPSFSGGTGKDLDQSFEVDTESVLDLSPFDELMCLDDLEAELLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAG0</accession>
    <name>A0A1C1CAG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major royal jelly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_05957</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAG0"/>
    <dbReference type="STRING" id="86049.A0A1C1CAG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05957"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08087"/>
    <dbReference type="eggNOG" id="ENOG502SI5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7776143at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF18">
        <property type="entry name" value="PROTEIN YELLOW-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650722" evidence="4">
        <location>
            <begin position="21"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT45459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="369" mass="40252" checksum="91F3B699D3AB7C3F" modified="2016-11-02" version="1">MGLRTLLLGMLLALTNTSSSQDPRVQVALTLQHPVNGVSTTPDGRLFVLYARVDGSTGPMVAEWHNDSDPTPYPDAEWNSYTVGSDPTTHLIRINSLRIGPDGTLWLVDTGSPSFGQPVILPDGPKLVQVNLTTNTVKRVYNLGNVTLATSLIDDVRFNPAVSLAYITDAGAAALIVIDLESGEARRVLENDPTTKGFMPPSGEGKLMHNSQGEFQYIYADQHEVSPGGQYYYYQPCGGGMSRIKTQYLNEAYYNSSFASILSQYPEPFALTPSTGGTAIDADGYIYNSDTDRQAIIKIAPNGTWTTLVQDPRLLWVDAMWIDTHGKLWMPAAQLNRGTPFNNGTSFVQKPLYTFTIDIGVGPSPIDHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAW4</accession>
    <name>A0A1C1CAW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar transporter chaperone 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">VTC2</name>
        <name evidence="9" type="ORF">CLCR_01433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAW4"/>
    <dbReference type="STRING" id="86049.A0A1C1CAW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01433"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03517"/>
    <dbReference type="eggNOG" id="KOG1161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000002">
        <property type="entry name" value="Vacuolar transporter chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="697"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="734"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="541"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="559"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT45608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="795" mass="90576" checksum="AE8B49C47738DD54" modified="2016-11-02" version="1">MRFGKTLSDSIYPPWKDKYLEYDKIKKLLREDETSPQGRGGEGSWTEQDEENFVHELTVAQLEKVHQHQVSIFNSLRDRTAACEAKLPSPEGEDAGKADQEYKEVAKELMPELDSISKELNELRKFSRINYTGFLKAAKKHDRKRGLNYRVRPILQVRLAQMPFNQEDYSPLLFRLSTMYSWARQTLEGEEAGKEAETDIKPTDEYTAYKYWVHVDNLLEVKTYLLRRLPVLVYNPQSVKVVDSSQRDPTITSIYFDNNNFDLYQGKVEKGTAGASLRIRWTGQLNDEPEVVLEKKFVDEATDSSDIRIQLKPKYILPFLKGEYKMEKQVKRLEEMLGADHDDVKAFKANIGEIQSFIQEKNLEPVLRASYTRTAFQIPGDDRIRVSLDTDLAFIREDALDPDRPCRDPDDWHRSDIDQQKMEYPFSAIKKGEISRFPHAVLEIKIKESNYTKKNAWLNDLMNSHLVKEEKRFSKFVHGVAELFEDYVNSFPFWLSDLETDIRRDPVTAYQEEQQREAQKAEDEMAVGSFIAGSKLSQSKGKAAASPSKFPERKLSGVLSPSVQSQPKAVASSQLETTAEERDDDETGVQAPEEVEVRDSSGGGIRSFLPGFSNSRYGRRHRQGRGAWENAPLPAGVKEPSFWIKDQGELKVEAKVWLANQRTFIKWQHIAILLATFSLALYNAAGVSNDIARGLSIVYTCFAIFASIWGWYVYMWRTRLITERSGKDFDNPIGPFVVTIGLALALILNFVFKYKAATGSDGPNPGNSTYSGPGVLSPKMQVPQASIAELLVQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAZ3</accession>
    <name>A0A1C1CAZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAZ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CAZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01658"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03592"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="312" mass="35463" checksum="4F783B93D2308BF7" modified="2016-11-02" version="1">MATSAAPGYFHEWRIDDAENRKQRRVPFRDGALHSNLPVQCALEEQDRIWPAHKDYKKPLDILVSLGTGKPLKEKEIPRWLEFAGVGDIAAAYYKNVINTDAVWDAFVNTPRSNYSPGRHFRLTIDLEERVGLDEWDKMYSLYDKVGQLYDSSSKEQAGLWKKIDEIAYKLTASLLFFEPEKCEPVLTRGQTQRREQISGTILCRLQTPSPALRTLIRRIEGFYHHAASRHVDTPLQLPRDWKNVALQAEQNGQPFGIPCRLDNAEGAAVRQSLLVKLKPPGEAGEGSLEPISGFPITFQELKAGMFQRGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBD7</accession>
    <name>A0A1C1CBD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01514"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03727"/>
    <dbReference type="OrthoDB" id="10648034at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="557" mass="57489" checksum="04D12087CC890FFA" modified="2016-11-02" version="1">MSFTVVDTSRDVLPSLRVAVAVHDIIVILAPTMQRSIRISPPSLTLLLCLCFEPRQRQGFCSSQSARSAPQKPGPQRRSSATRQVLLGASAKTEILLAAIRQVLLRASAKTRHGVCLMLLSKLTPSSLTSRFSVTTSTSTSTKASATRATPTGALLLRHSAHTKRELTLHRRASKMKIPAILVLIFAVALVILGLETVPARSTGDAPLLLVPASSVAAGLVSGSASLGPSFVTTLPTLPTVPLSTTDTPAPPPSPSTSVEPSDLPPATILVTIISPVSVSSATATVTVVELSANLFTATVTTTLVTTPVASVPVVTSVTIVTTTTTTASAVTSMLSSTGATSLSSPSRRYQNLAAILAGTLGPLALVAVIACTACWVVVRRRRARSRAHPSTVRDSWYGYNQGRCTACGGGASGEVNPSLYTTVELPLWQSRVRARAPRADMVDEEARTSCDTIPFPPLGVDEEEEEQQRQEQRQVMEGGKEEGWSVADYSSTRSGGGSGGGSGSGGGSEVAVSETGTVVVSRPEAVVVAGGGGGGGGGGGGGKGLRRRAGLENLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBJ4</accession>
    <name>A0A1C1CBJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative RTA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_01643</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBJ4"/>
    <dbReference type="STRING" id="86049.A0A1C1CBJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01643"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03739"/>
    <dbReference type="eggNOG" id="ENOG502QU4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT45846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="313" mass="35300" checksum="00A84F346A87C43C" modified="2016-11-02" version="1">MAVNPYHVNPLYCDEVSEACPVKASIYGYYPSLGSNAFFTVYFGLCFFINFWLGWRFRTWTYQIAMCLACISSAIGYIGRCLMYNNPFNSLGFQIQICCLTFAPAFNSAALYLILKHLVIQLGREWSRIRPKYYTWSFIIADFLALTLQGAGGGIAGSAGDNESFRKVGDNLMITGISWQVLTLLVFGAATADYTIRRFRSTQPWSPSAQLLLRDRKFRIFVVAQVITYICIFIRCVYRIAEMAKGWRNPIMQNQGLFIGLDGVMVGVATLLQTLVHPGHFFPALATYRETKRTRTAPQELSSSEDSVEKSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CBR4</accession>
    <name>A0A1C1CBR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxal oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000018">
        <property type="protein sequence ID" value="OCT45902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CBR4"/>
    <dbReference type="STRING" id="86049.A0A1C1CBR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00066"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00055"/>
    <dbReference type="eggNOG" id="ENOG502QPS4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="172" mass="18699" checksum="598711960B2101C3" modified="2016-11-02" version="1">MHAAVIPPSGQVLFLDKVEDYSELRLPNNRYAYSSLYDPETHGLISLPVATNPFCCGGSFLGDGRLVTVGGNAPLLWLDPTVQDGFDAIRYLGNQNGSYCWQEPGNKLASNRWYASAQTLADGKMFVAAGSLNGLDPSNFSNNNPTFEILDENGVSNGENILMDILVDTMPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCM6</accession>
    <name>A0A1C1CCM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCM6"/>
    <dbReference type="STRING" id="86049.A0A1C1CCM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01055"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09293"/>
    <dbReference type="eggNOG" id="ENOG502QRAT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5579281at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902657">
        <property type="term" value="P:protein localization to prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040345">
        <property type="entry name" value="Mug56/Spo71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039486">
        <property type="entry name" value="Mug56/Spo71_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057379">
        <property type="entry name" value="PH_SPO71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029217">
        <property type="entry name" value="Spo7_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076:SF1">
        <property type="entry name" value="PROSPORE MEMBRANE ADAPTER PROTEIN SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15404">
        <property type="entry name" value="PH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23207">
        <property type="entry name" value="PH_SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15407">
        <property type="entry name" value="Spo7_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01316">
        <property type="entry name" value="Spo7_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="614"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1089" mass="123647" checksum="938FDD806035FFE0" modified="2016-11-02" version="1">MSTSQVMPLGSTTSQHDFDALDPDSYTAHRLKHASAEHLHLTSRRFFIGPIPEGWLNSHRKSWYRRRVELSTYSSRRQSFRATTDHGPHHRTLTGLDGPSTAARMSFSFPQPEDVDDEASSAGDATDVEEQGTQEGEEEQDEPRNIEPVATTDLPRFLGVEEEEEEDEDVQGRKGSKLIPVPQDKGLDGTNDLLGTARSAEAESYRTAQENPFSDSKAATPVLAPQQSAHDGGGQDDAPDEPANRVSLQPSTLTQDTADTRTPLLPVEAAGAAGKSLQQHEPTPLVNDQNYQLVRSHTGVRFKVSEGVHKGQHKMVNKAVRAQDRVANRRLRRNPLREGTIVKMERMLVRVDMTLQQVPDDFDENESVKIETRMLDKWREFMVVARKSKKQDIDDFRLQIYKTRVIPEIDDERTKKKPTHEIRLDPKTTRVNLYSALDKTVVVWHPYKKGTRIIVMRPISMAHSVEWYTFLRDALGLERPTTLQVNVPDLDLTLRLDRPFEGLEAAGLEAADEETAIARTVAAEKAVSGKIISRCLDMLERDPEWSNVLQVWREAAKMGLAWKRYDRLEWVYGANEQKMYGTMAMTRSHNLELRPKQHYPTTSYGRKGVSHVEPAPIEGFLIRLTSQKGVHKRMGKAFFKRLYFSTHNQFLVFNRPAKATPPHPPRLATIGGSNVPSAHEIVEKTPLMYEIEPYKLQNGEISWLSSGNPDSLQQHDRDAVEEARRNVANIGDADGYVNMCNIRKVRTIKWGASPIDESLETGSSSDVDFHQDVSDTREEDGSTKEIDDDRVFELLLDNGLVIRLQAYSKQTRDEWIRRLKKLVKYWKLRVAAEMDTFKTIRKANLEQLNVDEEMEAIIGQFAKKWEVSRSEASPELYNMCGISSCRTITMSGSLFLKKRRRATFRRCQVILSGGKLLIFQSALRKSTGEQVRFIHQEKQEEVDLKDCYVYSGLLVEDDLLYQNRTFDANHPGLASLPRVYLEDGWTSADVDFMTCFVVWMNRKKGWFKTAGSDEAATSTGADEGKSTGRTRARLKRVGQLGVPGRGMVFKCRSRAERDHWVLSVASEIERVVEQEAENAGDESEFRFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCN7</accession>
    <name>A0A1C1CCN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01344"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="140" mass="15326" checksum="EEDDCEE59130D691" modified="2016-11-02" version="1">MAQLILVQRMDILQRPARILGVGPIAPRILSLHQPGCLVGCPAVDAKQDALRRVVAPADHRVEKHELAGPESRGVVGQRHDPSDGPPADGLRWVERVFQRAGVEGRGVGEDRRAEDLNDRAAREKGGCRLGLHYQGRAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCY2</accession>
    <name>A0A1C1CCY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCY2"/>
    <dbReference type="STRING" id="86049.A0A1C1CCY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01280"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09179"/>
    <dbReference type="OrthoDB" id="5425061at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018555">
        <property type="entry name" value="C630.06c-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09428">
        <property type="entry name" value="DUF2011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="293" mass="32724" checksum="0311B5263DBC8570" modified="2016-11-02" version="1">MFAVPNAKRVKRSRLFHEDDDSHASRASSTSMSPGEPPSDNAEVSYGFEYDFVTPGLSDVKASRPPIEPLPLDDAEEPEYEFRLFAPGPSSGAQHRQAQPGTADAKVRLSATPEPVALADALSLDKAHFVRPNRQESYYFTAALPKDTVRQLKAEYAAVAMSSTDIISLAESTRWPGTALPWRVVQVELLDKQSRSGIQHPSTHVDSTTSQRNSSAQHKAQARTRPSKKRRILVRQRLALRKELASQAQATAEMEREKRTRRNREKKVKKKEREKRKKSEAGGGEQSIERGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCZ4</accession>
    <name>A0A1C1CCZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_01346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01346"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT46341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="99" mass="10853" checksum="867B641D16076DEB" modified="2016-11-02" version="1">MPHSGMYEQYSYWRESVCGGCRQMWVCLDIIVQLVSGRCRLVVTAAATKKPDTLPIEDAGIADLTDSGHKVAGYLAYHDQATSWTDSLVAVTGRVAGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD11</accession>
    <name>A0A1C1CD11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component RRP45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ribosomal RNA-processing protein 45</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rrp45</name>
        <name evidence="13" type="ORF">CLCR_01281</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD11"/>
    <dbReference type="STRING" id="86049.A0A1C1CD11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01281"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09159"/>
    <dbReference type="eggNOG" id="KOG1614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000005">
        <property type="entry name" value="Exosome complex component RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="32"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="12">
        <location>
            <begin position="191"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT46372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="291" mass="32116" checksum="383A08FF9F294485" modified="2016-11-02" version="1">MPREIDISNIERNFILEALQQGVRVDGRSLDQFRSLELEFGDEYGTVTTRLGKTRVHVQISAEVTKPLEDRQFDGIFTITTELSPIASAAYEVGRQTEQEVILSRTLEKAVRRSRAIDTESLCIISGAKCWSIRADVHVLDSDGGLIDCSCVAIVAALRHFRRPDVSVDGENVTIYTMAERVPVPLSIMHNPVCITFSFYHGGDTIVLDATRSEEQVRETSATFTVNDFELCQVSKMGGSPIDAVVLLKCINTALAKGKEINGIVAKKLAEDSTKRDVGGLIAELRAENER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD74</accession>
    <name>A0A1C1CD74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Double-strand-break repair protein rad21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_01123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD74"/>
    <dbReference type="STRING" id="86049.A0A1C1CD74"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01123"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09095"/>
    <dbReference type="eggNOG" id="KOG1213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21788">
        <property type="entry name" value="Rad21_Rec8_M_SpRad21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.580:FF:000004">
        <property type="entry name" value="Double-strand-break repair protein rad21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="401"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT46432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="612" mass="67182" checksum="6CB9B45E9DBA1232" modified="2016-11-02" version="1">MFYSEQLLAKTGPLARVWLAANVERKLSKSQILQSDIQSSVGAIVDRGHEPMALRLSGQLMLGVVRIYGRKARYLLDDCNEALIKIRMTFKSTNNHDLPAHATAAVDLNLPELLTIDDLFSSMDFTFNMTQQPAITDSQTQDLGEDWTSSLNPQQTSTQSMLTPGEEPLYNDDDLNLDFTGGDDMAMNDTTVSINVGRNAATTKPADDEIFGEEGLLHDDEDGLNLDFDQDVPMLDQPDVQMADDTLPPVGEEEPLVWGDDETLQLRQTAEDARERRETESPLSEANPELLDELDRSFQVQLAEEEEIEEVAAQQRQRIRKQKPIAPDAETVLHNKQIKAQAEDRSKILRAPSFLPRDPLLLTLMSMQKNGDFVTNAMNDGRSMHWASELQGLLSFETVMRSGERKRKRDSGIGGLSEDEHSEKSPRLEGPEDTVEDEAVQLDGAQPLTPAPDDLPLQPMSEGGPALEDIVQGEDDEGIHGGDDTFDDTTMPLVHPADSGPISLGTKHAVHLLRDQLGDAGGAHPSSPARKSVLLQDLVPEGRTSKEDATKMFFEVLVLATKDAIKVDQGNTAIGLPLRIRAKRGLWGSWAETSPGDDPTTNTASQQVAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDC8</accession>
    <name>A0A1C1CDC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Pyruvate kinase</fullName>
            <ecNumber evidence="6 17">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">pkiA</name>
        <name evidence="20" type="ORF">CLCR_01877</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 17"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDC8"/>
    <dbReference type="STRING" id="86049.A0A1C1CDC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01877"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01263"/>
    <dbReference type="eggNOG" id="KOG2323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="18">
        <location>
            <begin position="31"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="19">
        <location>
            <begin position="392"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCT46534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="524" mass="57467" checksum="3CC2DE4C11A4586D" modified="2016-11-02" version="1">MGDALDHLANRTKLEWQCNLNIDYQPKKNHRRTSIICTIGPKTNSPEKITMLRKAGCNVVRMNFSHGSYEYHQSVIDNARQSAKDYEGRPVAIALDTKGPEIRTGNTPGDADIPIQAGLELNITTDDKYQTASDDKNLYVDYKNITKVIDVGKLIYVDDGIQSFEVLKIVDDKTLRVKALNNGQISSRKGVNLPGTDVDLPALSKKDIADLEFGVKNKVDMVFASFIRRGEDIKHIRKVLGDKGKEIQIIAKIENQQGMNNFDEILKETDGVMVARGDLGIEIPAAKVFIAQKMMIAKCNAAGKPVICATQMLESMTNNPRPTRAEVSDVANAVLDGADCVMLSGETAKGNYPKEAVNMMHETCLLAEVAIPYANVFDELRSTAPRPIDTVESIAISAVGASMELNAGAILVLTTSGQSARLVSKYRPVCPIIMVTRNATASRNAHLYRGVYPFLFPEPKPDFSGVDWQKDVDKRLKWGIAQAIKLGVLGRGDSVVCVQGWRGGQGHTNTIRIVPAEEDLGLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CDR3</accession>
    <name>A0A1C1CDR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.150</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Type III PIP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CLCR_01779</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.150"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CDR3"/>
    <dbReference type="STRING" id="86049.A0A1C1CDR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01779"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01330"/>
    <dbReference type="eggNOG" id="KOG0230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000283">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000005">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="14">
        <location>
            <begin position="443"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="15">
        <location>
            <begin position="2093"/>
            <end position="2427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="122"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="505"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="584"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="655"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1105"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1780"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1945"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="605"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1105"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1117"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1785"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1958"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="2012"/>
            <end position="2022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT46601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="2469" mass="276145" checksum="A0BA626F648106E9" modified="2016-11-02" version="1">MPSTSTIQDKDSQKDKDRDSPSASSIFLPLGRTRRRDSKASLSHELDQDALNQALNNIHTAASQSNNLTVFNDYTDPPTAASHIEGKSLASEIQGGISGLYNKLKATVGAAKDVDEQYQETQPALSVIDDRASSTSKISSGLTSRAPSPRVTASDPPPPPEPPSSKVSSKPTSISRPSVPSTPALRSPTGPPQPSSHIVDPSVTSVNIHAIGSANHSRTGSTLEVESPQQRSLATSADSDSLRKALQKPSKESSFSDRASSSLTSPVLHARGTSSSHERGLSQTSIQGHFSNTDGLNSPPILVSPQAEKPTARVVVHRGESAQHPRHINPLDLLAENAAPSKGASASHARSIEHSGLKSPGLITLEPRPADKLAPKISQSRLPGYYVSRTTSSDSSVSAGVLRANLDHMDDDSRIQFVSRTHQARPISKLRSKLLSKEFWMRDENAKDCFHCGEQFTTFRRKHHCRTCGQIFDNKCTVLISGSHFGSNSPVRVCKPCQSIIMSHDDDDSSDYSIEDLALSDPAPRPRTPEPPPLNRALARFEDDNASVTSQSLEQMARTPTMNFPLRRAFDGANRNSAILEFDTTDRPLPRPSSSRSLKATHSIGHTHKRHHSKHQHIRNFKAYHEDRAPFQRRTADEGTKEYKSSAFHRDSIIDPDLAQYLSDDPSTDEEPSIGETLSQDKLSRSGHDSDRSAIGGLLAAVRKGRSRLGDRSIAGFLNLGKDSDEASITSSRNVEALRGSRKRNLSVSSSIHRGTPRTTRERLQLIIPGSQDDAQDAYLETPSIYHGRSRMIRSASMHGMAAPAMELNRASIQHVHRMLQQLLRDANVPRVQSWEDALVPILLKATDDVDPDVQGGDDIDIRNYVKLKKIPGGRPGDTAYISGLVFTKNVALKSMARSLTNPRILIITFAIEYSRHEPRFMSLDPVIRQEKEYLNNLVGRIAALKPDLLLAQRNISGLALELLEKANITTIFNVKSSVLEAVSRCTQARVAQSMDKLTSLADPFGSCDSFEVRTFVAAGRKKTYVYLSGCPPQLGCTIALRGADEETLSKIKRVTEFMVYVVYNLKLETCLMRDEFALIPSAPNTGAEETTALSVNMVTKVVNNQNDATSQDSDAGTEKTDTRLPDQGDVSNAEVIALEKEGRFTQATRTDSTDSVHIPDDIPVPTFYEDLVLKHETRILSASPFVRFMQPYLLMRARELERRVAYLKRLRDQDLTVEQTLEEKGKNSKFTLIHPEMVHRPLAGASRKVREIIHAVHDAEYEKAAYNYESQKKQWETYLSGNRNLFDPFAHQNIVVLFSLVSTATSVPCSGPDLLAFSFYNEHETEAEFEADCTLGQYVEDLCYRATEICPSDACEKKMHEHHRQYVHGEAQITVFVQPYPAKMRGFQEVILMWSQCKICGVETTVTPMSTSTWKYSFGKYLELSFWSADLHARAGICPHDLHRDHLRYFGYKDFALRVHYDPIDLLEIIVPRMRLTWKVDNDLKFRNEIFSRTEHRITKFMVSVKLRLKNINIEAVEPEKADACREEIERLTKKANEEHAALIKQLQERYTNSRYWETIPLNSAVRATQEKVTEWDDAFADFERNYFPTEKDIRRLATLQLKKIFLDRDVSVSSLKSDDEGTTTPPIEEVIDEKDSLSEKLAIEKPSRLSPEKTQSFLQSVLEEHATSPPRERETSVATVTEVTKSDIENLPSMLEGPRNIEDVKHLDLAIATPLQPATVPVEDVPLQSTLSPKLGQASTSGTEQAVIVEPDADNENLEAAVPVPPTPPVGLLHPGSYGAVRSPTSRRTPDAKSTSPSLSRAHSQPAGAVTLRSHAGQVSSNTLSAVNAMNGFSRPSPVMSAKSGDSEANIPEKKLSERLGFSQLKNKTFTKGQSLIPRAVSHRKDSRVSNLAKHFEQLSREFERERIRERRLRAQRTMQSRVYPLPVSKPIVEVFKDVDEAVDERGDSDDVFGLEEERPSEESGKTANTAEGMADVASREEGSGVLAEEPPAEATENETDVQASTAASEIEESDVDEPEEEIFLPDSPEDLMRMSQEDIDLKELPKHERTSLMKMLTNFWAERSSSGWTALDYPLAASEHIFADCDIIVREDEPSSIIAFALDSEDYKTMLDGMQNEPPQDDGVVDFIGHVHADQSEVMHSLLRKTGRHLKYQFQEGPAKMLCKMFFAEQFDAVRRKCGVADRFVESLSRCLKWDSKGGKTKSLFLKTLDDRFILKSLSPIETQSFLKFAPNYFQIMSEAFFHELPSVIAKMFGFYQIIVTNKNTGLEYNWFLLVMENLFYDRVPTRIFDLKGSMRNRKMNATGERGEVLLDENMVEFIYESPLFAREHSKKLLRSSVHNDTLFLARQNVMDYSLMVAIDDTRKELVVGIIDCIRTYTWDKKLESWIKDRGLVPVRGGGAKGRPTVTSPREYKKRFREAMGRYVLEAPDCWHLFRREGRERERNARLLTERMPEGGQDGDEVEILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE69</accession>
    <name>A0A1C1CE69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE69"/>
    <dbReference type="STRING" id="86049.A0A1C1CE69"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02062"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01453"/>
    <dbReference type="eggNOG" id="ENOG502SA1F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5384020at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="263" mass="27885" checksum="BBC708B97B5887FF" modified="2016-11-02" version="1">MSDQNTPPSPSFAQHRRRSSIVEMFSPRLNTSSSAAVSSSPPSAGVPSTPTVPQHRRGTSITALGLTTNPSNQSHFSAFGLQRRASVATSSVASSPDFKNSFGDEPVVLEEDDTSRAAINPPPSPSFARRVSFGAQALRDVRLGGSPGASGGGRRPSSSLLTTLDENSENATASRRATSGTAKTAGEGFNWSEAIRDRTKRSPSFSSGNPFHQGGAARPRSASISNPEPPKEIPKPIESPPARMMRKPDHLGERMLRGDFMMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CER5</accession>
    <name>A0A1C1CER5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_02427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CER5"/>
    <dbReference type="STRING" id="86049.A0A1C1CER5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02427"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02417"/>
    <dbReference type="eggNOG" id="KOG2963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="30"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="464" mass="52786" checksum="D882B0AFB1584A97" modified="2016-11-02" version="1">MAKVRRKKRTHIPNNDNSTKTNQSGRRPKSMVIRMGAGDVGSSVTQLCRDFRAMMEPDTASRLKASRNSSRHQERRANKLKDYTSMAGPLGVTHLFLFSRSNSGNVHLRVALHPRGPTLTFRVEHYALCKDIARAQKHPRGGGTEYLHAPLLVMNNFTSAEAEKDPIKKQLESLTTTVFQSMFPPISPQSTPLSSIRRILLLNREVQADGTYVISLRHYAITTRRTGVSKRIRRFDAREQRLREKKSGAALPNLGKLEDVAEYLLDPAAGGYTSASETELDTDAEVEVLETTTQRVLSRKELQRQQEARKQSGEKDVPDSNARTASNVEKRAVKLVELGPRMRLRMVKVEEGICEGRVMWNEFVTKSKDEEKELEEKWTKKRQEKEARKKEQRENVERKRLAKKNAKLNSGKDGDGEGEQSEEEEWDSDDLDEWDEDDDMADEGGGAKDGEDEDEDEEEDEMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF45</accession>
    <name>A0A1C1CF45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Acetolactate synthase</fullName>
            <ecNumber evidence="4 12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ILV2</name>
        <name evidence="17" type="ORF">CLCR_02291</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 12"/>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF45"/>
    <dbReference type="STRING" id="86049.A0A1C1CF45"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02291"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02287"/>
    <dbReference type="eggNOG" id="KOG4166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="102"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="300"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="508"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCT47143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="699" mass="75867" checksum="65F920181A6A9629" modified="2016-11-02" version="1">MATKMTAIRPGSSAMRSISRRRLSCSQPFSSTTPTAALSPYRKSSKPSPEHSKRPATTAAAQAQSSRPIPSPAFNHDFRRHEPSPLVNRQAPELDDSFVGLSGGEIFHEMMLRQGVKHIFGYPGGAILPVFDAIYNSKHFEFILPKHEQGAGHMAEGYARASGKPGVVLVTSGPGATNVITPMQDAFSDGTPMVVFCGQVVTSAIGTDAFQEADVVGISRPCTKWNVLVKNVAELPMRIKEAFEIATSGRPGPVLVDLPKDVTAGILRRPIPTQSTLPAHPSAATLAARDLSKKQLDRSIARVAQLIDIAKKPIIYAGQGILGSPDGPKLLKELADKANIPVTTTLQGLGGFDELDPKALHMLGMHGSAYANMAMQEADLIIALGARFDDRVTLSVSKFAPQAKAAAAEKRGGIVHFEIMPKNINKVVQATEAVVGDVTANLAELVPKVKAVKERPEWFAQINDWKARFPLSSYEKETPDGLIKPQQLIEKLSNMTAHKKDKTIIATGVGQHQMWTAQHFRWRHPRTMITSGGLGTMGYGLPAAIGAKVAQPDALVVDIDGDASFNMTLTELSTANQFQIGVKVIVLNNEEQGMVTQWQSLFYEDRFAHTHQKNPDFVKLAEAMGVQARRCLKPADVEASLRWLIEESGDGPALLEVVTDKKVPVLPMVPAGKGLHEFLVYDEAKEKERRAVMKQRSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF67</accession>
    <name>A0A1C1CF67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF67"/>
    <dbReference type="STRING" id="86049.A0A1C1CF67"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02662"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02310"/>
    <dbReference type="OrthoDB" id="4119622at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17609" checksum="A53A43AABB34CE6C" modified="2016-11-02" version="1">MGDPVSIAASILTVLQVADSLVTFIRDLKNASEEHRNVQAEVQSLQSVLRQVYESSATANTTPRKEGFEETPFTGLKDSLETCRLHLEYLTIKLAPMHGFDKARKSVMWKMRRTEIRSILTDIERQKASLMLALQIETTSVFRVIPGSNALARLAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF89</accession>
    <name>A0A1C1CF89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">sof1</name>
        <name evidence="12" type="ORF">CLCR_02482</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF89"/>
    <dbReference type="STRING" id="86049.A0A1C1CF89"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02482"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02249"/>
    <dbReference type="eggNOG" id="KOG0268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000657">
        <property type="entry name" value="U3 small nucleolar RNA associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000743">
        <property type="entry name" value="U3 small nucleolar RNA associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="57"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="231"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="274"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="11">
        <location>
            <begin position="308"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="368"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT47184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="398" mass="44943" checksum="CC4EE5117FEA70C6" modified="2016-11-02" version="1">MERMFAAPFIGQLGQGHVDGVYSMAKDPGSLERLASGSGDGVVKVWDLSSRDEVWSARAHENVVRGLCWTPERKLLSCATDKTVKVWDTYTSEKSSVPLATYLGQGAFTSISHHRDHPSFAAASSSISIYDLSRPSSGPSQVLRWPTSTDTINAVAFNQTETSVLASAALDRAIVLYDLRTSLPLSKVVLRLASNAISWNPMEAFNFAAANEDHNIYIFDMRKLDRALNVLKDHVAAVMDVEFSPTGEELVSASYDRTVRLWNRDRGHSRDVYHTKRMQRVFSCRFTPDNNYVLSGSDDGNVRLWRVDASSRQGVKSARQRQKLEYDQALIRRYAHMPEIRRIKRHRHVPKTVKKAGEIKGEELKAIKRKEENVRKHSKKGSMPRHSEREKMVLGTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFJ3</accession>
    <name>A0A1C1CFJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CLCR_02239</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFJ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CFJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02239"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02129"/>
    <dbReference type="eggNOG" id="KOG0056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF503">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="245"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="559"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="835"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1004"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="860"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="921"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="934"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1008"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1035"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1108"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1144"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT47305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1156" mass="128026" checksum="A33826F7DD252CD4" modified="2016-11-02" version="1">MIPNTTSETVLLLRVFQILTVGAPALFFAIASIYSSFSVKPSTKAGGGRLRKAQLSLTLFAGVLSAAEAAFDLKKSDPSKTSDPDAVYSLFLTLVYVILSIGLVDDNAAASYPHHGAWAILLICQGTVFVLCIPRASSEDKLLFAHGLLQALRLTVTLILLAGSLFLQNLQYKKNTGTEDETRPLLADEASATGPAISSETKDPDDDEVDRLRIRSRPFWQCVYSFKVFVPYMYPKSPSLQLYFFGMCICSAGSRVVIVALPLTLGALVDRLGESVPWKQITVFVLLKFLTSSAGVPLIETWLSYRLNIDLMLGLQRHCYDHIMNLSADFHDNKKSPIIWQVMNQGQDVIDLFHDMLFIFVPQLIDLVSAAVVLSYLFGPYMTFIVATTAILFYWLTFKALITKRSLRRSWLDAYHDQYYQMSESTLNWSTVCYFGRIPYELQQYREKGDVTRGKMLMWWSWEFWTRGLRNIVPCATFAAACTVAALQIAHRQLNIGDFVILITYWSQLTSPLSSIAGELSRLTEMLVNAEELVVVLEKAPHVQDLPVARPFTFLEGAVQFENVSFSYDGKRQVTKGITFRASPGTTIALVGQTGGGKSTILRLLFRFYDVDQGRILVDGQDIRHVKMESYRKHIAMVPQNPVVFNMSILENVRYPDIDCTDEEAIEACKAAALHDKIMSFTRGYQEKVGERGTKLSGGELQRLAIARAILKKADILLLDEATSAVDSITERNIQASIRRLCAGKTAFIIAHRLSTILHADHILVIRDGQIAEAGSHESLIKQDGSYNELWRSQLRLQADERSCSRARSPQKSKAQVLINDLNSSGEETQTLVKSLSRSSKDGRLSEQAYGADSETSSTYEKDQAACDESHANSDGRGRKLSKRLAGALNRSMSRSKSPKKGQYSDSGLNPDAPTFRLSRSKSPQKAGSSESALKPDVRTFRPRRFQDGHHSTNFSEEAPSMSETLLKRATGDPVNQIGFNAAANNENNSKSSLAQAVFPLKRKWTGKGRETLDSNGDSEHYGVAEATPDADDAQSDRLEARVDGIDKKQTKSVSGHVRRRETASEPFPESVYEEDDSEGSSGDGNIMHSAKYSRLPQVMRGRAVSAVERKAVKAQGSEEKSADETEPRAPVNTAATSPGVLTPKSNQKFSSNLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFJ4</accession>
    <name>A0A1C1CFJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02661"/>
    <dbReference type="OrthoDB" id="4161387at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="158" mass="15781" checksum="97D660811C2479AD" modified="2016-11-02" version="1">MPYPHPDPDPQPSLTYTSAGQCTAAGQFLCLSASTFAICDASLTGTVQHLALGDYSRCGTGSGSDSGSSGEPGHSAVAATGVRTHTNYVTVTATPTRPQSASTPPPPPITSTKVVTVGKSASRTFAGTMTVAGISVVPTRIVSASGSPSPPPPPPKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFY0</accession>
    <name>A0A1C1CFY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03380"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01998"/>
    <dbReference type="OrthoDB" id="2831684at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650801" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="431"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="533" mass="57380" checksum="BE0440F86C8904E9" modified="2016-11-02" version="1">MQSLIQIFTLATLSAVLATVQAVPAPRSAGATVPLTLTLDNSSINFDVARTAESAQPLNPQLISLSIEFGNAIDFFGDVGKPNEFSRKLLQNVVDRSGVPPVLRIGGNTGDKWVYCDNCTAALSSIIEVNPNNPLSTEAVTVTVGRAFFQALEENVPPATKYILGLNFGANIYEIAQAQMDAALKYFNQSRILAYELGNEPNIYAAYPPLKRPSTWTVVDYGKQMLSWMPRLRARAQTNAPSFQFGSIIGPPTSFSDFSLAALAKMGVPQNIGGVKYFAAHGYPGNVCTKEASDQTQLTTYINHLETVDFVSQYQGEIAAAKSAGASFHIGETNSAGCHGKDGVSNTLGALLWEIDYALIAAAAGVDRLFFHNGVGGFYYAMWEPLPANSTTPAHINPTYYSMLFVADVVAGLSQPTISRIVKLDTFDTAQYAIFERNRLQKLVILNTHYYNDTSEARPSKFVNVSSVLGPNIKFRRLTASETTATSGITWAGQSVDASGTVVGKLVTEHASNGVVELLASEAVIVERNGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGE8</accession>
    <name>A0A1C1CGE8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_03599</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGE8"/>
    <dbReference type="STRING" id="86049.A0A1C1CGE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03599"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01849"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="350" mass="39188" checksum="5CF8C12B8E1917C9" modified="2016-11-02" version="1">MATGGLEHVITTAEREPSGSDIILLPGQSDPLPASEGCVICLDRITDQATALPCRHDQFDFPCLGTWLQQQPVCPLCKTSVTAIRFKVVGRGDGKSQLFYLPPAEQPQQPANRAGNGLAQQQRLRRHRTGGRGGGNRGSTSGFARPEISKDTALDFRRHVYRHKLYSLHVGSNRISRYRNLTPASFAKDERLTSRARMFIRRELQVFDFLNPSTAQSSSCSKSNDRRANNVDFLLEYIIGILKSIDLKGSTGQAEELLKDFLGRENTRIFLHDLEAWLRSPYEHLRDWDRAVQYAMPADADGEGSERANSLRSMDVCRPSSQSRLQGGGSSVPRWFADNFVLRDHSASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGF9</accession>
    <name>A0A1C1CGF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGF9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03751"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01854"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="127" mass="14008" checksum="37667771627AB1FE" modified="2016-11-02" version="1">MERWKLEALGQIETDESLEMGMEFLKAASDTSTLAARYLILLERIQTQKSGRETPMPGPVPGQGHTTQLDSDSGNPALLSADRTPWQRADEAPFPLNSDLTDLDDLLFGTGLPRDLLSADWSTFESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGN2</accession>
    <name>A0A1C1CGN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cpr6</name>
        <name evidence="14" type="ORF">CLCR_03525</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGN2"/>
    <dbReference type="STRING" id="86049.A0A1C1CGN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03525"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10149"/>
    <dbReference type="eggNOG" id="KOG0546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000009">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8 11" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="13">
        <location>
            <begin position="12"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT47626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="374" mass="41682" checksum="6531F41489C5407F" modified="2016-11-02" version="1">MAEPKSGRPRVYFDISIGGRKQGRIVLELYNDIVPKTAENFRALCTGEKGIGKQGKPLHYKGSIFHRVIKSFMIQGGDFTRANGTGGESIYGEKFDDENFELKHDRPFLLSMANSGPGTNGSQFFITTVPTPHLDGKHVVFGEVINGKNIVRTIENLPLQSDKPVGGDVVIDDCGQLEGESYNTATQKVADPTGDPYEDYPDDQGESMKGEEYYKIALDLKDFGNKAFKAGDVETGIEKYQKGLRYLNEYPAANDNDPKDLQSNLDHLRFTLHSNSALLAVKAKRYEEAEKWATFAIEAPPKDAKDTDKAKVYFRRAQARVALKDLEEALKDFEQAARLAPEDAAIKSELAKTKKTLADSLKKEKESYKKFFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH39</accession>
    <name>A0A1C1CH39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH39"/>
    <dbReference type="STRING" id="86049.A0A1C1CH39"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03362"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04514"/>
    <dbReference type="eggNOG" id="ENOG502RACM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4160688at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="655" mass="70678" checksum="D13A39D59526AD3F" modified="2016-11-02" version="1">MPWPAKPPMTLKEAKRAYKRDGATVRYTASQMARADRIDAREEKRKKELERNRQRVENKRKREEKAERERTVRQKMLEEGRISIEDTWGKVTASQPRLNRFFGQKAVGASVKGKRDREDLVSADKESALTEEIVANDISQGLRDAVQEEIPITVSEAALAPPRRTAAPTLTSPDKSQPVQAKPSPLGDDRPAVLRVLTSSQANARSSAPAGTVNKSHCGPPPSCAELPRSSLPFSLGSAISPRDTGHSLLASPLSAGRDVVSAGSSGSPTELLPARVGIDAGREKGERKGHRLEHSTPEQEGFNKTVTAGAQLPQSSLDVEDDEDFTDGIDDATFLMLCATQKPIRIASSTPNHEPPTSPTSSVDTRICSSPKEDSRVEPGTRTSRTTQATIKPSKELSESFNSVFNEIEDEDLLALAVEVEAQLATTKQTPTEAPAAKSAKVEPPPLAQQQPLRSRGTPKRRPAAPRGRAKVTRQEAPSQETTAAAARTPTSQDCAEETAKLKVNANLSRAYTTPRIPGVAGSGPSDSQAIESSGKASWKIARATGMNIRAMDSNPRAAVSAPRVNGLTPSSGDPKAAGHSKTVSPSRPRGYPPKPSPTPSPWPKPVKRHRYPWDVSPVDEFPGLGPSTQALSLELLAQVEAQIRDEERKLQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHB3</accession>
    <name>A0A1C1CHB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldose 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GALM</name>
        <name evidence="4" type="ORF">CLCR_03600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHB3"/>
    <dbReference type="STRING" id="86049.A0A1C1CHB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03600"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04455"/>
    <dbReference type="eggNOG" id="KOG1604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="330" mass="36401" checksum="A78FC8EF6AC6A68B" modified="2016-11-02" version="1">MASDSGFSFLPQGAIIQEFKVAGHNIVLGYPTPEPYATSPFFGETIGRIANRIKNAEFSLNGKSYKLAANEGPTHIHGGVKGWGKKQFNGPQPVNRNGKEAVLFTYVSRDGEEGYPGTVELRVWYTAYTEDEAGVSKTVLETEYEVELIGDETEETIVNITNHGYFNLSDGPTIEGSEVTLYTSKYLVVDNLLIPTRAIEDFPGIEANKPFILGPTEPDIDHCFVVDTDTSNFSIDTRQRPLKPLISVSHPKTQLHLDVFSTEPSFQFYTGKHIKAAATADTPARGSRAGFCVEAARFINAVNVPEWRNQVVLKRGDVWGAKTVHKAWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHB4</accession>
    <name>A0A1C1CHB4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03667"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04454"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="213" mass="24178" checksum="0C1A5347D77371DC" modified="2016-11-02" version="1">MAVNPFPPFKPNEWSMRCFGRPTRSVPVIGKIPKLGGFTLKGRTPAEQERFKSPCKTIVFDPGPSFLFVGTVFTADKNPTSLRHGTNTTQGEPWRRKQKGQTSANTLAVSQSEENEVKAQMYEHMTGQKIALPPPATLRLKRFLTERWTALCKYMAASAFLPSKAARSTLDLHNLPSNHMPSFWTNRQRQQQQQQQKSNHPVDCLLFSHRQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHW3</accession>
    <name>A0A1C1CHW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_03863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHW3"/>
    <dbReference type="STRING" id="86049.A0A1C1CHW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03863"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08275"/>
    <dbReference type="eggNOG" id="ENOG502QSMN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14654">
        <property type="entry name" value="ZIP_Gal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005600">
        <property type="entry name" value="Gal4_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="398"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT48124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="806" mass="89056" checksum="F1D55FF29F3BB4BD" modified="2016-11-02" version="1">MADASKSDHTSSNAGQSCRECRRRKGKCDGRMPIVLDAKVGARRPVHECRTKYLHRHLTEVEERLEKAEALLRAFFTDAQLSQMLAHGITNGGNFQPRLGGDSTNPSSHVASSDHPFEQTAASPTAGIVPGMQQRTQSFSPAGAGPDQPIDVGYLESPTASRSNLADDAQPLENPPAADDDFEWDERESSWNVADPGGGHATSGGGVDAEIPKITDGMATLTANDSNAGFLGSVSGSALLRLIWMGAGAEGTTSDASSERRRTLDQLFNQRSSEYPSASTWLRAQPMLTRAMVDTLVDAYFALYHPTFPILHEPSFREQYARLSGRISRSTWHTLANLVAALGSFVSSTCSDETHATLFNAVKANLSIESLETGSITLVQAFAMAANYLQKRNRPNSGYNYGGIALRLAISLGLHKEFRGWQTAPFKKEIRRRVWWSLCVLDVGATVTYGRPLNWPQVGVDIPFPSNIHEKDLPVNATSLPAEVNEATIYTYVRTQSSYHLHTIRIYNRLISNPIPSATELIALDDEFIDGWLKSLPPYFRDDNLPLPHEYLLGHAISRWRFRIMRIIMYRPFLIRWAQDRLDATVTSPMSPSQAQSAESIATKRCLKAAEECISAIFDFWSSATHTRLAAWYVLYFLLQAALIPIHCLRRNPTHSDAPRWRDSILTALSIINAMNNLNPSAPKCRDIIYRLCGESLSLKSRTQSQSQVKQETSSWNAFPTDTSYGNPFSFQNPDPTDAGGNSWMTEIDTAIEGYDIYVDRLSNAAMAGMGRMTSASEASMPDAFTHSDGTQIGTGVQDWDWGLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHX5</accession>
    <name>A0A1C1CHX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04410"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="150" mass="16653" checksum="670840019C236FD3" modified="2016-11-02" version="1">MSSPDIPRRASLDVPPERTPYNKVRLNSTRIHQTYSHGRHLSTANPFVSGPFPPLSRPRKAEGFTRGRYNIAPLINVTEPACIPPYYLAATSARSKQSRPPPPQQERTEVAGALGLGLHHLEFECQSSREVPSRPRPFSTTGDPNDFSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIM9</accession>
    <name>A0A1C1CIM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIM9"/>
    <dbReference type="STRING" id="86049.A0A1C1CIM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04332"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08496"/>
    <dbReference type="eggNOG" id="ENOG502SDCM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5431245at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037738">
        <property type="entry name" value="Ecm13-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826:SF1">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="249" mass="27849" checksum="BB0B16140E5EDD96" modified="2016-11-02" version="1">MPSSVTFSASTATTKASAQSIYTRPQKKQKMSITQTYFLAHSARGKLSKEAARPDHDLRLLVGHANMLDSLMLDLATAEQEQERWFNNIVNGSQEAEEEEKSSRHVETIVEEPEHDWEPEDATSSDDDDESEDEEKPNTKITAIEVDSDMSEDDDEESGDLALVRTASRHSPPELSLDTDSDSDDEHMPPSPPTMTIDVLSEKQRQAIATTSYYDVKDNASLSQEESEAFEQEGFYLPSRQQPTIIAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIQ6</accession>
    <name>A0A1C1CIQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04331"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="252" mass="26746" checksum="E4C04951051A9196" modified="2016-11-02" version="1">MAVLVQIQPRDLVDNAASTIDSQARAAQQFQPSLSNLHSVPSLGHIPAVLKFSPSTQRTSHPLIPGRGGAVLRSKPPKAPVFGVLGAASLHVREGDATALVDSSNLAQTTASQDDLFDLATPPDDEIPSAASNNQPPRRSRLTVLTLSAIRPATQSVQGLLSLPSDEPHPPLQSPSLVLHTESRITTHNPFSPVRASLTPLSSLSTLWANDFSKALCLQFLAPLSPLPSENARVQIARPQLRVGLELLSLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIY0</accession>
    <name>A0A1C1CIY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIY0"/>
    <dbReference type="STRING" id="86049.A0A1C1CIY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03907"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08608"/>
    <dbReference type="eggNOG" id="ENOG502S2Z9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3946741at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="737" mass="78861" checksum="066FA1419AA3BA06" modified="2016-11-02" version="1">MRYPTWTSPGPASTSHDDLELRARQASTNTCLPQSILSTVPNCAVSCIASFAGLNYPGATCGNTSDLGYLCIQPNIAGLTIGEGSVQCVVASCSGQDQLDVDVYNICDGIANAQPRTARTITATIIGSATSTASTMDSFPASIGNPTSTEAVSMIVMATDSPTWIIATSSATSTSAAAPSASSMSSEPAATSGASAMSNTAPPSGGLTTPQIAGIAVGGAATVMVVLGLFLLALWMRRWRRQRCRSQRRSRVIEQTPPPDYQSPPKKATPTFDTIGSSLTVPHANGRFYGAQQPMEEKRRSFWRKSIRPEDIGVAVSPEIPGEHSPVSASSEQSFSLLLPTAPVAALRPAPLDLEARRDRRRYTQRPVSDATEFDEEPQTRAQEPERILIDNQPFILEKPPLAKRPRGAPPNLKLPAVPESSPRNASHARIPLTPTYDNGNIDFASPPRSVLSPMATQGPVPVAERKLPSSSAYANRNVLRKNPPQRLPLRAPSGPPVEPLTKPRSAPRPPPVPPTTRKAVSRRSEIAAMQRQSSVSSAYTEIEEDTTPEEINKQLGLRANPPTAINSTFPQQVAADRGSPIKDLRYPQIPRSAAVSRQAERPAQPRTSPGLASPPVPAPRTVPAVRPRRDELVRAEASFMQTDTTSSDGYYSDSTIEFPIPPTSKTRMSSLSQLRNNPSSGNKGIVPPKTLTFLRGESSPETKTVDVTLPQRSPSTKARLTPSKSSTGDLYLTVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJK5</accession>
    <name>A0A1C1CJK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NifU-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_05043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJK5"/>
    <dbReference type="STRING" id="86049.A0A1C1CJK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05043"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03246"/>
    <dbReference type="eggNOG" id="KOG2358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="3">
        <location>
            <begin position="72"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="313" mass="34275" checksum="B42C28FF4F8529E1" modified="2016-11-02" version="1">MRGVFSSQALRTLARSRTQQPLSQACRACRTRNIHQSVRLPAITSSNARRRPLLQPSSQKAAPVAPNRSIYIQTQSTPNASALKFLPNHPVLPEGFPSTFLEYNSPRSTLAAPHPSPLAARLLDVDGVSSVFYGPDFITVTKAEDVNWAHVKPEIFSLITEAITSGEQLVNTVDKSTSSEDGQGGLGEDSLAANDEDDEVVAMIKELLETRIRPAIQEDGGDIEFRGFENGFVNLKLRGACRTCDSSTVTLKNGIESMLMHYIEEVKGVNQVLDEEEEIAMKEFAKFEEKLRQQKGPDAVASTVGKGSLDFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJY2</accession>
    <name>A0A1C1CJY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative DNA replication factor C subunit Rfc2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_05119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJY2"/>
    <dbReference type="STRING" id="86049.A0A1C1CJY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05119"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03083"/>
    <dbReference type="eggNOG" id="KOG0989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication factor C C-terminal" evidence="5">
        <location>
            <begin position="147"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT48828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="254" mass="27186" checksum="FDB6EC80C54851F1" modified="2016-11-02" version="1">MEIYSTSTRFALCCNYVSRIIDPIASRCSKFRFKAIGGDQAAARVAEILKAENVNYADGVIERTLKVSDGDLRRAINLLQSAARLVGASTASEKPNASGSGSGSRKNFIREDSDDEMEDVDSTSKPKDQTGTAIQISDIDEIAGTFPPALTDSLIKVLQKGNTRNYNNIANEITDIVASGYAANEVLSALYAKIIVGDEGDIVIAKKGDVATALRKKAALTQTFSEFDKRLIDGVDEHLALLDMSCQLAGVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK18</accession>
    <name>A0A1C1CK18_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">YPT35</name>
        <name evidence="12" type="ORF">CLCR_05189</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPT35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK18"/>
    <dbReference type="STRING" id="86049.A0A1C1CK18"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05189"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03033"/>
    <dbReference type="eggNOG" id="ENOG502S8A5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07280">
        <property type="entry name" value="PX_YPT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037917">
        <property type="entry name" value="Ypt35_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="78"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT48873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="192" mass="21551" checksum="C2E1926D2AF78E4B" modified="2016-11-02" version="1">MDDPSSTAKAELGPEQWSQNSLDAAGDQSRPTPLPPPYWKPSRESSFDELSALRPPPITLEDHTLSREASRAALWAKSITIDEYVIVRGNPLGAGAYVVFNCRVQTLDGGPMTIRKRYSEFDELRAKLMKAFPQATKSSLPPLPPKSAIYKFRPKFLDKRREGLEYFLNCVMLNPEYAGSTLVKDFIFPPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CK39</accession>
    <name>A0A1C1CK39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CK39"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05036"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="281" mass="31421" checksum="82A404152F547D0F" modified="2016-11-02" version="1">MSSRRTRRQQTTYINTTTHFPNGRRRIEEELVIAGLSTTTNNNNNHGASPVRYIWFNLQVLAVSPSILRSEPRSTKVLRTEPFQVEVEVEVEVEVEVEVEVETAIEVDNPLPPRRIDSFRDTGRRVSIADQRGVGGEGELFVQRGSWREGWFFVVVVANAIATATATVENSAARSRSRWSTSELESKPESKPEQDTYPSAIESVSRSLTRKEERRWLYQRRACRVGDGTGDPGSEGLTGCVGKADESESNPKPKLESKSKSKSKSTIPTKKKLMVRALAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKC0</accession>
    <name>A0A1C1CKC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_04952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKC0"/>
    <dbReference type="STRING" id="86049.A0A1C1CKC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04952"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02948"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="50"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="150"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT48960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="300" mass="32886" checksum="D133B6C52C9B63FA" modified="2016-11-02" version="1">MADLLSLKLIHLFSAGVDHYTNHPIFTDSDIPITTSSGIHGPPISEWIIMATLVASKHYNVLYEGQKAHQWQHDRKLLMSTTDWVGKTVGIAGYGSIGRQAARIFNAMGAHVHAYTASPRSTADSRKDKGYIVPNTGDPDGTIPRAWYSGTTRASLHTFLASGLDALIIALPLTPATRHLFGTAEFDLLARSNPPADQPGKKSRSAFVINIARGALIDQPALVKALNDDVLVGAALDVADPEPLPAEDPLWAAKNLVLTPHVSGLGREYSERAYDLFITNWTRRERGERMFNLVDRRRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKR9</accession>
    <name>A0A1C1CKR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKR9"/>
    <dbReference type="STRING" id="86049.A0A1C1CKR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04530"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02833"/>
    <dbReference type="eggNOG" id="ENOG502SPD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5386574at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021582">
        <property type="entry name" value="Aim21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11489">
        <property type="entry name" value="Aim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="879"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1095" mass="117536" checksum="662DA4018936E963" modified="2016-11-02" version="1">MSAAHVAPSIPPRPARVQQAAASQGVGKLPDIPPRPMNKRLERSVSPGNFPRSPLNEPWSANATRHKTNEKATDAMPRRPSVQNLPSIGQEGMEYADIADMQTDQQPPVSSLAVDAAAQTRNIAQDLHLHAPKPSLPKSSATAQVQAVTRTDSGHAAVHGLGKPSTPSPEEGEGLRQVRTRSSFSRPTSAAAGERRSSIFGDEETGPAELGLRVPINPSLGDVQAPSPAPGLSPSHTGTNGDRKRPGHSRARTSREIFTPPGSYGLHGHGVAPQDKFERDWYSKHPDAAQIEETHGHGVYESIGSGRGAFALSSDDLNKIVRETASRGSGFGTSGVTQSYPDEQIGYLASDLYVARSQQGTPNSLAKTVTNTSQPAHESPLRKASFPADDSIPAEIRRSRLSISGKPDDLDVVDSEQEGDTHIPPGRRFNKITGGEESLNESVETRPFVSHPTEEDDHVIEHGYTVPILAADEVAKGAGMEDLRPAVSPRQERRGSLEPESGAITPGSRPSSRPTSMYNLHSASHSLSRFLSHHEEQERMHTPLEDVHEYEPLFPDDDDKKPINHAERFKPRPDALKQRFPSQDIWEDTPSSLYYSATVSTPDLPAKPETAPPSKTFESPDAESARKEEVSEAEKAKLISKDERLAKSRFAPHLRDDMPTRPGMVPRFPSQDIWEDSPESHHLVTVITPRPPEPEEQETSPVDTAKPTIPPRPAKSRLGEGASSAQVAPSIPPRPSKASHAVPVLATPSPDTSKPKDTSPTLKKVPSIPDRPKPQIPSRPAKKPSADALAKTLSGDPAGSVEQEKVSPPVAKAKPQIPARPGASSKIANLRGNFLNDLNQKLGLGPPKEKEPEPVAEEAKPLEDARKGRARGPQRRAPAKSPAAPVKSTGFAIFAPRSLWTIEEGELNVPSTDGAPVSDMEATSEDVLSEKKSEQVENSTAADAPLPPTIDTTDHAEPQGSKTEAEELPSSASNLADPEPTLGTPTQEKSNPLSMAPSRNESGEKKAMDDGDAEDGEGVDLSQRTTESSGQASGPELEREEPDPTTDAIPVSKQTTASSKGDTVPLEKTASREEPRVLRNMLPEGEPGKESMEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKY0</accession>
    <name>A0A1C1CKY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_04801</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKY0"/>
    <dbReference type="STRING" id="86049.A0A1C1CKY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04801"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02829"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT49092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="56799" checksum="099A185AFC1F997D" modified="2016-11-02" version="1">MHFFLPLMLKGGDMSSYAHNYYDHLPILDKVTSISTLHDSNPFLFWTILRVACYRHPRFSHVFELSWQPYRLLLMSNLVAIIHDFRTIQAIVILCHWPNSGPRQSQDPSWQYCGIALNAAMQMGLDQPHPEKIAPGFHGRSNVHQMSVYSRHMTWLACFHISTSVWLGVPPHLSSPAQLNALSSTAKEPDVPQQFMVQIEIQRQVVQYSTSLAGDVDAATASTLLNLFNNELDNLFNAFRDTWSPRLEIQLLGAKLYLFSLCLTVVTKRPGLVNRMAEHYVPDPTRLPVQLGLPTAVSLIHNISKLNRESSVEPQQSASGVIHYPKFYFRLVVFAVGFLMKFLSTNPNASQEDRELAISHITTAHQFFSSFPTGEDFARVAQAIEVLAKNLRSDKQDDSDPIRTRSGASLLYDIFQKFRGQPERFAGSDDNTTTTITGAPIEAWKQHDDASRTTALSTINAGSTSVWAPVGTYSEMSTFQPGLEESLDSLQWMSDDMLSEMFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL36</accession>
    <name>A0A1C1CL36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CLCR_04547</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL36"/>
    <dbReference type="STRING" id="86049.A0A1C1CL36"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04547"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02734"/>
    <dbReference type="eggNOG" id="KOG0468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001452">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="130"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT49199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="982" mass="109135" checksum="049365CDAFD47691" modified="2016-11-02" version="1">MDDLYDEFGNFIGEAASDEEGSQDGDAGQHYVYDEESDAEEQPAADGLMEVDDEGPSNAVILHEDKQYYPTAQQVYGEDVETMVQEEDAQPLTQPIIAPVTQKKFQVQEADLPPVHYSREFMSDLLSFPEGIRNIAVAGHLHHGKTAFVDMLVMQTHDLQERLDKRIGRRRDEQLRYTDTHFLERERGISIKAAPISMVMQGTRGKSHILNIIDTPGHVNFVDEVASSMRLVDGVVLVVDVVEGVQINTEQVIKHAVLEDLPMVLVINKMDRLILELKIPPTDAYFKLKHVVEEVNTVIENTIPGRGEKRRLSPEKGNVAFSCTSMDWVFTLPSFAKMYAETYPKVDANEFSRRLWGDIFFNPRSRKFTRKGVEEGSKRAFVNFVLEPIYKLYAHSISESPEDLAPTLKTLGITLKPSQLKSDAKDLLKLVCAQFFGPASGFVDMVVQHLPSPVDGARRMLDNYYTGPLDSKVGEAMTRCDSDGPLVVEVTKLFSSVDAKTFHAFGRILSGTASSDQVVRVLGESYSVEDEEDSTMSTITATHLACSRYNIPVSGVPAGNLVLLSGIDNSIVKTATVVAEKFADNEDAYIFKPIRHFTESVFKVAVEPVNPSELPKMLEGLRKINKSYPLISTKVEESGEHVVLGTGELYMDCVLHDLRTLFAEMDIKVSDPVTRFCETVTETSAIMCYALTPNKKNKLTMIAEPLDDGIAQDIEAGVVKIRDPIRKVAKFFEEKYEWDKLAARSIWAFGPEEMGPNILCDDTLPSTTDKKLLKSVQESIKQGFSWGTREGPLCEEPIRNTKFRVTGAELAPEPIFRGGGQIIPTARRAVYSSFLMAGPRLMEPVYSVHMTGPADAVSGLYTVLMKRRGHVISDGPVAGTPLYAAKALIPVIDSFGFETDLRIHSQGAASVSLVFDRWDVVPGDPLDKSIKIRPLEMAGPQQAARDFVLKTRRRKGLSEDVDVKRFLEPELLAGLRESGVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMB6</accession>
    <name>A0A1C1CMB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_07318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMB6"/>
    <dbReference type="STRING" id="86049.A0A1C1CMB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07318"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09848"/>
    <dbReference type="eggNOG" id="KOG1477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT49591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41218" checksum="4D54A46726406446" modified="2016-11-02" version="1">MGLFKSLKGKIEVGTDNPGREEYSSPSGPPPSHRHRGAEHRDDGFTPPSGPPPSYRGRGHDNDAEEYAAPPGPPPSHNRRAEDDFLPPPGPPPASASSNANANPPPYHDWTVIPDTALLPPPPPLPQDYSPTNNATYDSAARAHEWCARHPVYTPSRPSHELHLLANAGHVTLEAPPGPLKRHVSTFRQTSPTTWRVGTHKNQQDAIFLSSVPLYFACADSPLTTGRAKTIFFQIHVHRIHNANSGIAIGYAARPYPPWRLPGWHRASVGVHGDDGRRFVNDPWGGREFVAAFRENETVGIGMKFEAQEVAGRRVKTRVFVTRDGRADERWGWEVDEERDERDEGVDGLMGEGDLYAAIGVFGGVEFDVTFGDGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMH1</accession>
    <name>A0A1C1CMH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-ketoglutarate-dependent 2,4-dichlorophenoxyacetate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfdA</name>
        <name evidence="7" type="ORF">CLCR_07188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMH1"/>
    <dbReference type="STRING" id="86049.A0A1C1CMH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07188"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09896"/>
    <dbReference type="eggNOG" id="ENOG502QUAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF3">
        <property type="entry name" value="(3R)-3-[(CARBOXYMETHYL)AMINO]FATTY ACID OXYGENASE_DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="12"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT49651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="319" mass="36525" checksum="A6B97A19DD843034" modified="2016-11-02" version="1">MPHAVDYSLIQVKELHPTFAAEVSGVDFSRPVPEDVFQELWKAVNQYGVLVFRHAKLNDELHIQFSQRLGDLDDVLPHIQAGRPFRFKHKELFDVGNIEEDDALVKPGSHRWYYGKGNNLFHHDSSFNPRRAGLSLLRAHEIPPPGQGLGGNTDFADCRTAYDDLPADLKKQLEDNDYVVAHSLLHSRRKAAPEYFTDVDPDKGYFSRHKVVQTHERSGRKTLYIGNHMHHVEGLPEEESTALINRLLDHACQDKYVVSVEWQNPGDLILWDNTSVMHRAHGGAYEGKYRRDMRRTTVHDDSSYAWGLNEKTSMRVGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMJ7</accession>
    <name>A0A1C1CMJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06974</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMJ7"/>
    <dbReference type="STRING" id="86049.A0A1C1CMJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06974"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08659"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="529" mass="58281" checksum="C4E5E8B0FBD2CB01" modified="2016-11-02" version="1">MASHDVHQDYIPDSDRSSSNRVKLDAAEYVEAPVTVGREPPPYVKSLNPEERRIAERALVRKIDFRLIPTIIIMYILNYLDRNNIAAARLAGLEDELKLHGTQYQTAVSILFVGYLLMQIPSNLFLNKIGKPRLYLPIAMVIWGTISAATAGVQSFGGLIAVRFCLGFVESAYFPGCLYFLSSWYTRKELGFRTAMLYSGSLISGAFSGLIAAGITKNMDGTAGLRAWRWLFIIEGCITIVIAFGAIFVLPNFPRTTPWLSPEEKELAVWRLDEDIGQDDWVDSKQQTFFNGLKLAVKDIKMWIMMLMLFCIVASGSVTNFFPTVVQTLGYGDIESLLLTAPPYVLCVITAFLNAWHADRTGERYFHVTVPLYVAVGSFILAAATTATAPRYVAMMLMVPGVYTGYVVALGWISNTMPRPPAKRAAALAAINAVSNTSSIYASYMFPKSDGPRYVLAMSVCSATAFIAICAATVLRLILMRLNKKLDRGEWVEGAINSGPRGAAHKHDITVQEGAIPGEAAARGFRFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMK6</accession>
    <name>A0A1C1CMK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_07771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMK6"/>
    <dbReference type="STRING" id="86049.A0A1C1CMK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07771"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT49765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="117" mass="12214" checksum="BDE269CB7D70DA2E" modified="2016-11-02" version="1">MAFLTGVPNGAFTIGTSDAVTHTWPKNCPTPTRHFPKAIFAQIGLGFIDAWLSAIALFSLSPPRSPRLITTRSSSSESSSSRHSGGSCTRSGNTKGPNVAKDGQGEYVASEGCASRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMW0</accession>
    <name>A0A1C1CMW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_11336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMW0"/>
    <dbReference type="STRING" id="86049.A0A1C1CMW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11336"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08763"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF215">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="490" mass="53252" checksum="6907FF9327DC2BA6" modified="2016-11-02" version="1">MTGRGHAINAPLSVTIVGAGIAGLCAAIALRRAGHNVKILERSPLLDEVGAAITLAPNAVRIFRSWGLDFERAKLIPRLGQTFIDGTTLAELRATDRTDFEATYGAPYLFAHRVDLHAALRELATGADGPGPPAELHTSSMVVDYDAETGRVKLIANNTWTEPTDLIVAADGVHSRAASHILGRECLAHATTSTVIRFLIPTSLVLADPMTAPLLRYGEGHCSFYLHRDKRRWLVRYPCRANTLQNFGMYVDRPLAASGDTNGWSQKCDHDHLRAALAGFHPALLALVDKTARGSAILPLWRCAERPPLPRCTDRNGGRLVVIGDACHPMLPHRGFGAINAIEDAAALGELFERSLTHAPEDGVQDGDDGDAEAGSPTVRDLLHVFETVRLPRACVAQLYSQVETDRDPVVERREQTLRLLPAEELPGNGAQVIDWVFGYDVVGQTRRAKKDFLDARKRGTCTPTGLDDSHEGANRKGTAQLITVQHLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CNB0</accession>
    <name>A0A1C1CNB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GA4 desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CNB0"/>
    <dbReference type="STRING" id="86049.A0A1C1CNB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07373"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08905"/>
    <dbReference type="eggNOG" id="ENOG502SMV5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="316" mass="35348" checksum="67C9195831C07A90" modified="2016-11-02" version="1">MASTTTTTTATLVAKAVPEMGGDVETTINYHPAGMDGTLNTVIPGTAGSYRRKFDTASVTIKDIRGKENQFSLAEQGFQLLKHTSEEKEFMDKDRIKGTAFPEVAELLKKTTGATDVRIFSHIVRRTPWESITKEIEEKQIPDDARVGKIGPAHFAHIDQGPLGAQQLFDETLSPEEAARFSKTRWGIINVWRPIKPVRRNPLALCDMRSVPDEDLVPVYTRAPRDYGSYTAEKMAKSYQSMTATSNPNHAWYYASGMTPDEVLMLQIFDTNKAPDGSSRRTLHSAFSHPDDQALEPRESIEVRSLVFWENEPIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CP79</accession>
    <name>A0A1C1CP79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CP79"/>
    <dbReference type="STRING" id="86049.A0A1C1CP79"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06679"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05673"/>
    <dbReference type="OrthoDB" id="3057599at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="789" mass="87129" checksum="6FA16D341E2D82E8" modified="2016-11-02" version="1">MDGPRFARPELRPGPASYPSASSLGRPPGSQAGSSSDVPFLHSHNDLSAPEPVFPPHQGSTEDGYDLSRHGSGRLTAFSDTSDERLAKLSFWPPILKWYATVFLTALYLGTAGAIVALWLAAGTNGQYHLSSENVRMISRYFPSALGTLNVILFRHLVREFIRMKPFIAMADQPGKPSPGQRPSKSVSGAFFPWQDFSVTRGLTSTVSLLCQFMVGFIVSLKVALLASGPAQDGGPGWTLTIRVWPAFFLIIGHIVMTAYVLWVAYLNAGKSTGLRWDPITIADYCALFAACNVAGYFSALELLHNRSAKHVLSTNHLFRLGYWKKETPGSVESIVYGIGTTYSAAERALDIYKPSLYEQMMGYNSAPSPVDDCGNYRNTNLPAPCSQGSWPSCEHYPYRHSPGCGKGWIVFAWLLVVAALGLAIFGLINGVVFQGFPLPKDWSLPSNMSVSAGHHTIKLPPIDPTDPESQLVAYALVFRSAPVYVAGLFTGTIVEWVDLNMRFMQPFINMFGQAGNAADTVLLAYITTSPLQVPITAIDKGHYRVAAFSTLNTLSPLFPIFIGGLLTLTDERETNTVMFNFSLSAYIGIMVFLSAWFIAMPFAYPVQKRLLPRQFYSMADLMAMCHKSTFLQRRYLDFADQRRTPSKDVMEARILLSGDRFMFGHYTDDEDKKHIGFDIHSTINFDTGRIEDTRLVEAVTPEGKMKVIRSQAARRVTTWFGDASGSQTSSKGLIAWLRRMRKQRRAQAETEMRAMRPVASATGSRLEEQRDVRQRAPVALASLGGTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPB6</accession>
    <name>A0A1C1CPB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_06916</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06916"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05666"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="16"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="510"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT50323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="553" mass="60858" checksum="4967024AD1427E61" modified="2016-11-02" version="1">MGRFNLRRIMDKQAQVVMVSSTAIALYGYDQGMMSLINTNYNYLHTMGIGEESPIVGLIVSVYYLGCAVGAVLASRFADAKGRKPGIFACLATASLGNLLMFVAGLGKSTTRHAALATMMIGRIIMGLGVGGIDAVVPVYSSELQEDDARGTALAQEFQANIFGLNMAFIINVVITQTLGKWNQWAWRVPIIVMQIYPILLFTGANLLPETPRWCVLHGDNERAKRSIRRVFGPDQVDDRITELVSAHKKEEEEGMASYADMLWPGGSQFHPTVVTVMGQVNQALTGYGAVSVYGPQIFELLGFGVTTAEYITLGNYLSYFAMMTVAWVLIDRVGRRKLMINGAFWLAVSFALLTLLGGLAYNRRALAIPLLATGVPGIVVLYLATSVFGVGWLVPPWLIPTEIYPSTARAQGAAISVIVWGLANFAVTLLTPIGFNNLEFYLFLVFAATNAVAGLWTYLYCPESGHRTFEENQDFFKEAADRGSWMVSRVRDGEFKKLPAAEVEDEEEVEVEVEVDGGDEDRRKKKERRRKVQKKLDAHGETTPLLGRTSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPB9</accession>
    <name>A0A1C1CPB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_06673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPB9"/>
    <dbReference type="STRING" id="86049.A0A1C1CPB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06673"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05653"/>
    <dbReference type="eggNOG" id="ENOG502SM5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5418088at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="625"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="799"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT50338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="831" mass="95754" checksum="EFE890F77B47CD3D" modified="2016-11-02" version="1">MTENRYRPSSPPGRRYADPRASAGMFISSSFDPARYSSSSQPRGVIDTFPAARHGAVYSTQGIAKRQVLDDTHPGGGSIVRTEYAVRPRTNSTLENRRPVSTFAERRSSPPRIRPAVVSGPSRDDPRSPALAPREEQRYLVPAASTGRHHHRHASATRAEQDRLLPARVSRQPEYHRRGGYNAYPSYSTSRAPLQDEGFSYTTPKEQFLSESSRPPQRRDSHSRRERPVSMIGLPEYRLPARRDTRDGPPPSSTRALDRIERNEPLRHTSGRTSDTEDRASDLPRRRHSTRAPVLHHYPEDGYSSNRDDRDGRPLVRHRPDRQEDDGRPRHRHRDERDRESTRDLPRESDRVRERDRDRDRDRDRERDRDRDHNVKRIQEAERTGKPHSRDSSPDHSGLRKGITAAAVGAVGAAAGAAIKNARTKDDEGSESDGRQERKHRRRRHHHTSDEPSPDDLAGRLDRDLKLTNGDRGHRRRDDDRRGDDAEEDEDRRERRRHHRHQKHKDRDNESDTTEDYDGRESRHRRSERDLQEDPRHHRDSAASREEDRDVPPNLEQRTISPGEEDDGRPRKVQLVEPAEKKEEYKPKGILKPPREVPFPEDPNPTREGVAPLKDAQKDGIPPNARWTKISRALVNPEALEKAHERYEERDDYVIILRVVSKEEIMKLAEKTKEIRGMDFFRPRDNAQLTTRTEARERKWQAELEEKRRRRAERGEYSDESSESYTDDDRRPLPALEQAPPVQGFQGDPRVYFAQQQQQQQQQREEVPIAAAAPPLQPGMPNVAPPHQGLGSTAPYPPQQATSAQQQQQHPTMPVPDIRVEPNVGNYANNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPD4</accession>
    <name>A0A1C1CPD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein Swi5/Sae3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_07567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPD4"/>
    <dbReference type="STRING" id="86049.A0A1C1CPD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07567"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05631"/>
    <dbReference type="OrthoDB" id="255837at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034974">
        <property type="term" value="C:Swi5-Swi2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010772">
        <property type="term" value="P:meiotic DNA recombinase assembly involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT50366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26451" checksum="3116BC23F9AE358A" modified="2016-11-02" version="1">MAESRQQIHPRSNHHQHSLRQEIISSSDHTADSHRRETTSSSDSQAEAEEVEQHQNPRPTSHAGHLATTSTSGSQSASASTSTSSERVQTPMTQPQNPRQVQLQTKISTLQSNIEATEAQLALRLQKITELKSFRQQQRDEHQQQRDEHHQRRDSPPSSSSTSDTKSNNARHDPAREAAAAAAAAQDHAQLIITRHISLLKRYNEIKDVACGMLGLIAEKQGRTLAEVMAERGVSERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CPZ6</accession>
    <name>A0A1C1CPZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_06993</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CPZ6"/>
    <dbReference type="STRING" id="86049.A0A1C1CPZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06993"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05434"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF4">
        <property type="entry name" value="CYTOCHROME P450 98A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT50579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="556" mass="62852" checksum="F3FE688EEA03727D" modified="2016-11-02" version="1">MSWSTIFWAWAGVTALLLVGALGVLIHDVILWKRMPPGPQPLPFVGNKFDIPSKYPWIQFQEWSKKYGPIFTLWLGRRPTVIISDPVIASELLEKRSHKYSSRPRFVVMGEIYSQNSGILVAKYGKDWSVRRKVLHSVLTQKALQQYKPVQEAEAVRLCQMLVDNPQDFESLLDRFTASIVFTIAYGHRIDSMQSPIIRQRLKLMHIMASLNVPGRYLAESFPILARVPEALASWKRQVRGWGDENEQADKQLMNYVREDMENAKKPGAPPLAPSLARQLLEQRAADPATFALLGERDFNGLPASIFGAGADTTASTLCSAILALVTHQEVLPAAHAELDAVVGPNRLPLYSDEPALPYIRALCKEALRWRPVAVLGGTPHASTEPDTYKGWYIPTGTNILGNSWAINLNPEYYPNPDHFNPLRFLDTDPHALGYLPKEYLASTPRENDGLVHPSRLGHSSFGWGRRICPGADLASNNLFIAIAHLLWCFDIKPAKGVVYDTYNYTEGFNIRPQPYQCEITIRSEKHKEVLQREFVQARDHLMRNFPLFKEHEIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ28</accession>
    <name>A0A1C1CQ28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_06627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ28"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ28"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06627"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05420"/>
    <dbReference type="eggNOG" id="ENOG502QURR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651031" description="Dystroglycan-type cadherin-like domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="135"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="333"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT50595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="942" mass="101276" checksum="6C618D10B83B4A8A" modified="2016-11-02" version="1">MHLTGIRKPLLASYLLSALCLVTAAPQLAFPINSQVPPVAYVSEPYDFVFSEITFVTSAPQISYTITNRPKWLDLDSAARKFSGVPDADEVGAATFQLVASDSTGQTSTSVTFVVAESPELHIDAPTLPQLERNGPTSSPNSLLAHPGEPFDFSFGEDTFRGAAFATRYYAVSADDTPLPSWVHFDEDRLSFSGTTPALVSNLAGPQTYGLRLVASNVPGFAEAAIDFNIVISRRVFGFSTASQNITVSPDVPFQSASFRSFLSLDGQVVADNQVASIDADVPTWVSFDKSQLSLSGTPGISLNATITISVTDVYGDIARATVFLQSSADRSELLGTLAVVNVTAGEHFSYTLATPSFSHTSRATADLGDAQGWLNFDSLSRTLSGHVPLNLNTQTLDIRITLEDTTSTATGDVVLQVVQDTRATGVTATQVSKTQTLPQASVSSEDPVPATDSHNQKPNNRHTLRLILAIVFSVFGTSLVLLLLLCCLRRKKHSKRRVGKTSIEDSPGSGAGHGQRPAPRAALSTEILGLVNPQGPAPPRPPRLDLQWSNDMMGQPRHIGPLSQHRISQIFTNDRGPATVVATSSRAANTAEPGGTTDFAPAAASVKQTALSQGPLSPIVSRSSIAGRRSPNRLSSRLSQQIVQPAIVGLPDRRSGAGHGAGILLPPDATASRMSWRDTWTSNPSTDHRRTTLVLESFPAPPGDGSGSGKSPPRTKKPTPLLRVVSEDGDEAMSFEEQRQRWHTERARARLEGISRFSNGGSARMMGLVRTPWRARSKATETDEPSKSSSKPIVVGGRSYEHSWSQWSGVGPAARESLQVRSPPVSHILSRPVSRRRPSFASSGQFESVTSSDSLWEDEEDLGVEEPKQGFSRWQTDNSSQASPRLPFSPVPASRENSDRRSASNDTRAHTRVADGRQRVSVGERGRTRWSGSQSGSFRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQ54</accession>
    <name>A0A1C1CQ54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative CDP-alcohol phosphatidyltransferase class-I family protein C22A12.08c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_07166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQ54"/>
    <dbReference type="STRING" id="86049.A0A1C1CQ54"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07166"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05376"/>
    <dbReference type="eggNOG" id="KOG1618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF57">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT50637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="417" mass="47418" checksum="0F8F011366F3995A" modified="2016-11-02" version="1">MRVRSLDLIARSLTRPGASTRPWQPARSLSSNSRRRVPDFAFAFDIDGVLVRSSKPIPTASTSLQFLQQNDIPFMLLTNGGGKHESERVQDLSSKLAVPLHESNFVQSHTPFAELVHGDNSLRDKCIMVVGGEYGRCRDVAERYGFTDVVTPGDIYAAHPEIWPFSKPFQRDYYASFARPLARPINPASLADSLKIDAVFVYNDPRDWGLDMQVILDVMLSHRGYLGTYSRKNGDTSLPNSGYLQDGQPTLYFSNADLLWAADYHLSRLGQGGFQASLEGLWRAVTYHKNHKSAPELYKKVIGKPYRETYEFAEKQLMRHRESMFGNYHQQQQQQQSPPPKLRKVYMVGDNPESDIRGANNYDSPHGIEWLSLLTRTGVYRDEDGRRPTWEPTAIVDDVKAAVQWALKDSDWHQPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQL6</accession>
    <name>A0A1C1CQL6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_07744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07744"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT50786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="129" mass="13825" checksum="71EB9D9D8476839D" modified="2016-11-02" version="1">MDTPCGSSKKNAVNDDREDRGTSNSMMLVHNNATVRQDMLDVDVECGHVKMSHVPLLGKDVAQHGTLSPAWPVEGDPMARLCCAFLEPCRESDTDRRAVLTGLPRDLGIVANSDCAETATAVADTASEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQM6</accession>
    <name>A0A1C1CQM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Spliceosome-associated protein 49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sap49</name>
        <name evidence="9" type="ORF">CLCR_07366</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT50782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQM6"/>
    <dbReference type="STRING" id="86049.A0A1C1CQM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07366"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05244"/>
    <dbReference type="eggNOG" id="KOG0131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000121">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000288">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="101"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="335" mass="35679" checksum="58B01ACA32FA23AF" modified="2016-11-02" version="1">MSGARHWEQDKDSTIYIGNLDERVTDALVWELFLQAGRIANVHLPKDRVTQSHQGYGFVEFNSEEDAEYAARIMNQVRLYGKPIRVNKASADKQKSVEVGAELFVGNLDPMVDERMLYDTFGRFGTLVAAPKIARDENNLSKGYGFVSFANFESSDDAIANMNGQYLMNKEVSVQYAYKKDGKGERHGDQAERMLAAQAKAHGVQPTPATIPMGGPVFGGMRQTPVPPAGFGPPSGNYQAVPPPAQARPPPPPSVPLAAPPSGLPARPPPSQAGYGGPQGFMPPGFNQVPAGFPQPNVLPAGFAPPPGFGGPQAGTIPSAPVVPPGGFSGYGIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQS5</accession>
    <name>A0A1C1CQS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA damage-inducible protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ddi1</name>
        <name evidence="12" type="ORF">CLCR_08612</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Binds ubiquitin and polyubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQS5"/>
    <dbReference type="STRING" id="86049.A0A1C1CQS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08612"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09483"/>
    <dbReference type="eggNOG" id="KOG0012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14309">
        <property type="entry name" value="UBA_scDdi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397:SF3">
        <property type="entry name" value="DNA DAMAGE INDUCIBLE 1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397">
        <property type="entry name" value="SODIUM-GLUCOSE COTRANSPORTER REGULATORY PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="10">
        <location>
            <begin position="380"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="123"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="335"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT50838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="418" mass="45175" checksum="1009B3490B56EAE9" modified="2016-11-02" version="1">MTLNDLKTFVQAETNVPPVAQIFLKDGRPVIDTSVTLAQFGVSEGDLIAMAISTNPPRRRPADGTSGGESPAQRARNSSGQEQLRLRILEDRAVRAEVERQDPELAAAAQDSQRFHDLWDSRRRQNERMQAEKEANLARLEADPFNLEAQQKIEEMIREERVAENMQKAMEEFPEAFGRVTMLYIDVVVNGNPIKAFVDSGAQTTIMSPSAAERCGILRLVDKRFSGMAKGVGTAQILGRVHSADIQIGQYNLASSFTVMEGKDVDLLLGLDMLKRHQMCIDLKKNCLRIESDEIPFLPESEIPKMMEEVLENEPKVEGPGGSTIGTKTGTVMPGASASSSGAQVQATSNATTQSSASTTAGASPAPSAPGPGNFGQPQPITAESIARVTELGFSREEAIAALRQADGNVELAISLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CQX8</accession>
    <name>A0A1C1CQX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA-splicing factor brr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">brr2</name>
        <name evidence="9" type="ORF">CLCR_07880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT50899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CQX8"/>
    <dbReference type="STRING" id="86049.A0A1C1CQX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07880"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09543"/>
    <dbReference type="eggNOG" id="KOG0951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000005">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="549"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="772"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1400"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2112"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2230"/>
            <end position="2251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="2118"/>
            <end position="2135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2136"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="2233"/>
            <end position="2251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT50899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="2251" mass="254267" checksum="4C0F6C82B5583E3A" modified="2016-11-02" version="1">MADPNNVSQYKYSAMSNLVLQADRRFISRRNDENTGDPESLAGRLNIRDMGSRVGRETAPKQKKMAPALQGVDRGSIREGEDVLEREQRKRKRGEPAQTRGAGILSAGDALIEGLKYRPRTPATRATYDLLLTVTANALGDVSQEIVRSAADAVLEYLKDENMKDLDKKREIDDIVGITMTPKQFNELVNLGKKITDYDAQDDDDDMADGANNETELDERQGVAVVFDEDDDVDEDGVQRTYEVRDEDEGDTDDEGAQDLPGLEESATAGGAGVPDVEDGEDEDGGLVIDGGVGESSRRKREDADSIPIHEIDAYWLQRQIGTIDSDPHIQQQKTQEALRILSGKSPEGEDLSLRDIENDMMDLFDYEHPDIVSKFVSNKDRIVWVTRWRRAAEDADARHLVENEMVEAGQRAILDELLGKADRDGEASRPAKKMKLDLMDIDIPKAQEDQEEKKEGVLTGGLQPQRLINLENLVFESGNHLNTNPKVILPPGSTKRTFKGYEEIHVLPPKPRRDPGERNIPTSELPDWARQGFGSAKELNRIQSKCYPSAFQDDGNMLICAPTGSGKTNVAMLTMLREIGKHRNPETGEIMLDDFKIVYIAPLKALVQEQVGNFGKRLEVYGIRVSELTGDRQLTKQQIADTQVIVTTPEKWDVITRKATDQSYTSLVRLIIIDEIHLLHDDRGPVIESIVSRTIRKIEQTGDPIRIVGLSATLPNYRDVATFLRVDPQKGLFHFDGTFRPCPLKQEFIGVTDKKAIKQLKTMNDVCYSKVLEHAGTNQNQMLIFVHSRKETAKTAKYIRDKAVELETIGQIMRSDAASREVLQQEADSINDPNLKDLLPYGFGMHHAGMNVADRTSVAELFADGFLRVLVCTATLAWGVNLPAHTVIIKGTQVYSPEKGSWVELSPQDVLQMLGRAGRPQFDSYGEGIIITSQTEMQYYMSLMNQQLPIESQLMSKLADNLNAEIVLGNIRTRDEGVEWLGYTYLFIRMIRSPGLYSVGADYSNDETLEQKRVDLIHSAAVVLEKAGLLKYEKKTGKLQATDLGRIASHYYITHNSMLTYNHHLQPSIGTIELFRIFALSDEFKYIPVRQDEKLELAKLLGRVPIPVKEGMEEPQAKINVLLQAFISRLKLEGLALMADLVYVTQSAGRILRAIFEICLKKGWASVAKLALDLCKMAEKRMWPTMTPLRQFPMCPREYIQKAERMEVPWSSYFDLDPPRMGELLGMPKAGRVVCDLVSKFPRLEVQAQVQPVTRSLLRVELTITPNFVWDEALHGTAESFWIIVEDCDGEEILFHDQFILRRQFAEGDMSEHLVDFTVPISEPIPPNYFISLVSDRWMHSETRLPVSFQKLILPERFPPHTPLLDLQPVPVQALKIKDYVDLYPKWDRFNKIQTQVFKSLYDSNDSVFVGAPTGSGKTVCAEFALLRHWKNPEAGRAIYIAPFQELVDSRYADWNERLRQIGGGKVISTLTGEITADLRILDRSDLVLATPTQWDVLSRQWQRRKNVQNVELFIADELHMIGGENGAVYEVVVSRMQYIHIQLENSMRMVGLSVPLSNARDVGEWLGANKHTIYNFSPMTRPVGLQLHIQSFSIPHFPSLMMAMARPAYQSILQLSPDKPAIVFVPGRKQVRASAVDILNACIMDDDDARFLHTDVSELAPFFERINEQTLAESLKHGIGYYHEALSISDKRIVSHLFKVGAIQVMICSRDVCWEIPFTAHLVIIMGTQYFVGREHRYVDYQISEILQMFGRATRPGEDDVGKGVLMVPAVKREYYKKFLNEALPIESHLQLWLHDAFVTEISTKTITSTQDAVDWTTYTYFYRRLLANPSFYGLSDTSHEGLSTHLSELVETTLKELADAKIIDLDEEDDSLSPLNPAMIAAYYNISFITMQTFLLSLTARTKLKGLLEIVTSATEFESIQLRRHEDHILRRIYDRVPVKMSEPAYDSPHFKAMVLLQAHFSRMQLPIDLAKDQEVIVSKTLALLSACVDVLSSEGHLNAMNAMEMSQMVVQAMWDRDSPLLQIPHFDSKVVDILAKQGIKDIDEFMAAMDPSENPDQAKLVAQMGLSNRQLVEAAQFTNEKYPSLELEFQVEDKDDITAGEAARLSVKITRETNEDEDEDEDEDEDEEDGDGDGKGKDKDKDKDKEVDITVHAPFYPGRKLENWWLVVAEEKTRSLLAIKRVTVAKTTFATKLEYVVPTAGKKELTLFLMCDSYVGVDQSMAFNVDVKEGEEEEDDDDEDEDDEMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CRM1</accession>
    <name>A0A1C1CRM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TCRP</name>
        <name evidence="14" type="ORF">CLCR_08601</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CRM1"/>
    <dbReference type="STRING" id="86049.A0A1C1CRM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08601"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06922"/>
    <dbReference type="eggNOG" id="KOG0638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414569at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000001">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000020">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="43"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="219"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCT51149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="420" mass="46784" checksum="C370CFB980B3850F" modified="2016-11-02" version="1">MAPIALEPSPVSVHGLTKKVSHGTAPIIGTLPKNTKTIASYRGYDHVAWWVGNAKQAAAFYVSRMGFERIAYRGLETGSRVTASHVIRNGDVTFVLTSPLHAPDAKAAWLSDDDRAHLRVIHNHLRAHGDAVRDVAFEVDDVAAVYDAAVEKGADPVEPPKTVHDSYGTAKLGSIKTYGDTIHTLIERSGYSGVFLPGYRAVTEIEKTAKYLPRVDLLAIDHCVGNQDWDEMEAACEYYERTLGFHRFWSVDDKDICTDYSALRSVVMASPDEKIKMPINEPAKGIRKSQIEEYVDFYNGAGVQHIALRTDDIIATVTNLKERGIEFISVPDTYYEAMSKRLAQAGMKLHEDFAALKELGILIDFDEGGYLLQLFTKHLMDRPTVFIEIIQRNNFSGFGAGNFRALFEAIEREQMLRGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CT96</accession>
    <name>A0A1C1CT96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA(adenine(34)) deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TAD2</name>
        <name evidence="10" type="ORF">CLCR_09101</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine(34) in tRNA + H2O + H(+) = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CT96"/>
    <dbReference type="STRING" id="86049.A0A1C1CT96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09101"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06387"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1701769at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052718">
        <property type="term" value="C:tRNA-specific adenosine-34 deaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000039">
        <property type="entry name" value="tRNA-specific adenosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="9">
        <location>
            <begin position="54"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT51712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="219" mass="24109" checksum="06E96DCAC010A488" modified="2016-11-02" version="1">MDFLQGISGPGGSEFLSLADMDTSDDEMATLAGIKPEPTNDKDKLHPHVLANLELHQGFMLQAIDTAEQALKEGETPVACVLVYEGEVVARGMNDTNRSLNGTRHAEFLAIAQFCKKFPQAKLKETDLYVTVEPCIMCASALRQYGIRCVYYGCGNDRFGGNGSVLPVNSDKGLEEGYPSYGGIFRKEAIMLLRRFYIQENENAPNPRAKGNRELKPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTQ6</accession>
    <name>A0A1C1CTQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_08060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTQ6"/>
    <dbReference type="STRING" id="86049.A0A1C1CTQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08060"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06237"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT51888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="611" mass="68546" checksum="75142EAE8F783F9D" modified="2016-11-02" version="1">MWYTIKTFLASTYGQAQQSISPTGACSKTNPPDQSRQLLRYSAEHDKWTSNTTAMSLRSSGGGGGSTQEEQVTASLLRITFSSLILAFAPAALLLYLLVKRAGTKRAEARFEQSRRCGKPRLLRYRWPLAFDIIVEAFRMFEDNQILQWFVGIFEETGPTFEKTILGSRSIDTIEPENIESILYTNFSDYSLGARQAVFAPLLGNGIFTQDSAQWKHSRAMLRPLFSLNHPDTFTQVEEHAEHLLSCIPTGTFVDLQPLFFQFTFDTTTFLLFGKSMNSLQDKSARDGASTREAEFAEAFRVSQDFLFRRGRRGDLYWTVDNKQFRRHCSTVHKCIDEAVQEALSRASGDGKSGSVHSFLDALIEETRDPRVLRDQLLNVMLAGRDTTACCLTWTFRLLAQHPDVLAKLRSEIDSTVGVGKNSSSPDRKILKQMRYLSLVLREGIIPWPVVLRLYPSVPINSRTALRTTTIPRGGGTDGSEPIMVRKGEAVGFSIHAMHRLKRLYGEDAHSFRPDRWDPDVENAVDLKNIGWGYLPFGGGPRLCLGQEFALFEAGYVTVRMLQKFPTLVLDPRDTKIALGTEKQEVTLVLASKDGCRVKAARKAGDALVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CTR9</accession>
    <name>A0A1C1CTR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative carrier C12B10.09</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_08760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CTR9"/>
    <dbReference type="STRING" id="86049.A0A1C1CTR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08760"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06238"/>
    <dbReference type="eggNOG" id="KOG0768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="100"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="204"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT51887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="355" mass="38792" checksum="CDBCA7DF7A3CA18A" modified="2016-11-02" version="1">MSNNTGLDIWVAGAFAAFTVDLLVYPLDTLKTRLQSQHFETLYKDAAGKTKPSLFRGLYQGVGSIILITIPSSGAFFTTYEALKYSINEAIPPNSTIFLPQPAVHAVASGGAELVSCAILTPAEVMKQNAQMLSSRGKRRSTSLEVFRHFQKHPSRLWRGYTALAARNLPFTGLQFPAFEYLKGYFLKRRRDRNGGKPVDGIGERARITAMSAAIAGSGAAWVTTPIDVIKTRIMLAAGSGDDGFKNEPKSNSSSLLRVGIQGSRKSGLVVAREVLKMEGVRGLFRGALLRAGWTAIGSGLYLGCYESGRHYLEKNRRDAKEGDHLMQRDWSNVKVGIGGSRSQDVVKKSAWQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU16</accession>
    <name>A0A1C1CU16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_08196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU16"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08196"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06137"/>
    <dbReference type="OrthoDB" id="4120459at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT51993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="661" mass="71652" checksum="AD095D177E926E9D" modified="2016-11-02" version="1">MPPREDGATPKSFTWITGNPRSRKNITQIRRHAGQNSGVKAEIGARAQSSSSPRPGQRSSAKPSRAIYPSPRTDDTDGQPLSAHAEQPISFHVNYPSAAAEYAPAPSSVIHDQVVVPQSTHPDSPSTDVSASIGEYVAPTRKLAIWDLVNHSDEEEEQHRLQALASTPGQDTDDDRQDYFSGRTARTELKQALSEARSHSPRHPWKSSQPPPTTFAVQANVSKRRKATSGAASSSHVSWRLGMTPPPRLMSLSKEDSQIEQTLLQTSAFFWGQFESSWSAQLRERGNTYFDKISGMESFAGSITTAGGLLALGHVDSASSILDSALPKLPELLTSQHPQLCWLFADLSLSASSDTPLGRLRSQVKRVAASTSLTTLGASHPITKLLHLTFPATADAQRVYLRELIQRKIHELHETLFESNSYQTTGQYYYLGRVLGQVGQLEKARDILAEVVALWEEIYGVNHIMPITGLLELTRAHLSLNDASTDTEALLSEALRRTLTLEKATVSNEPTTSPAYEVVNAKAAGLIHSRIGCLRTLGRLHVMRGNLETALMQYTAAMSVGVEELGVHVPAVQLALADLDAVSQMVRAHRDGDESVRLEWLKKVPVEVGIRWANKNEVSRGIGKEGAIGQAASIEKLALSTSSSGTGGNEAVAESVAATAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU27</accession>
    <name>A0A1C1CU27_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II subunit beta</fullName>
            <shortName evidence="4">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_08717</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT51999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU27"/>
    <dbReference type="STRING" id="86049.A0A1C1CU27"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08717"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06131"/>
    <dbReference type="eggNOG" id="KOG3092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000003">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT51999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="320" mass="35385" checksum="1E0151F1B1AF830F" modified="2016-11-02" version="1">MAISVSITGTCIVLSSALLLATFVGFALFDKMEDFQSETDSDYTSYWRDWFISSRGNEYFCEIDEEYITDRFNLTGLNTEVHYYQHALDLITDVFDLDCEDDMRETIEKSARHLYGLVHARYIVTTRGLAKMVEKFKKSDFGRCPRVICESHPLLPFGPSDNPGLKTVKLYCAKCEDIYNPKSSRHASIDGAYFGSSFHNILFQVYPALVPVKSRRRYEPKIFGFKVHHAAALARWQDAVRRSQRKRLEDAGVVAEGQQLFIEDAESSDGAVDDRAVDMEDEEADAAAAAVVAVGGEVQGVGLQQGGAGSAAAAAGQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU39</accession>
    <name>A0A1C1CU39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_07979</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU39"/>
    <dbReference type="STRING" id="86049.A0A1C1CU39"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07979"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06113"/>
    <dbReference type="eggNOG" id="ENOG502QPPH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF2">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="481"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="668"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="678"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="701"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="717"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="750"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="790"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="879"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT52017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="973" mass="106289" checksum="C2F869C0A846A79F" modified="2016-11-02" version="1">MDLERIKQNLRLRSGRSKKTHKQPVVRSNATPHVDEVNQKNKPNGEARKSSGPARQPAAGVDQQSIPGTSKNSETPQSTSSGAANVAKHRPPLTHASTSSNLKPLVDAQPQRFGKSGMERPRQGPVNELAITRTMSENDTGTGLLDEDSSSTLDFDLRAPPPRPKPPSIETLSESLFSTGHLNTLLRDAHHLARFTSFLTKYRPQYHPVLLRYLETQKAIKAVEYANAVAEGVPLSSDNDKEGSSIPRASVAATLDKVFEEASTAAFRLMLDSALPMYITYNLVKVVSECLVNEITGRQTPLMRDLVGGLSEVFCLSDPKQEDNPIIYASEEFYRYTGYGPDDVIGRNCRFLQGSKTKRESVARLRETIGKGEDLCETLLNYRRDGRPFINLLMIAPLHDDKGNVKYHIGAQVDVTGLVARGKGLDGFEQYMFSSEMKRREREARGKNLETDEDVRKPRALAKLRELSEMFDLEESAVVRSHSRSASASGDEDERSIGSSRKGGRRVLADSDLSSDNDDEDVADNADKTWKLGQSGRSGLSGRLPGVYESYLLVRPAPSLRIVFVSPKLRGRLGNVIQHPILSHLAASANTLSGLKESFGNGVPVSAKVNFLLEAGSRRDGTATRVGTRLEDAGHGRVCWISATPLLGSDDKIGVWIIVVVEKTKVPTKSQKEILTRSEVNQLPQQSGSNHARMDPKGAKPSLPQQGSRPSSSPPKQNRENHDPPIKPKRLQDTPGPTHNSRPPSAHPEQAQREERTEDSEIHNPSQVSAEYETLVLQEGGEEAIGATPDSANNSQTGAQNDSDVDIPTTGTRPPALDRSSGPDIDEGNDDDKAESSDTAVVINREQSTPDETSPKGRIKLQSPDDDDLDQSPNTPDSPTKHEDMVTNHMLEESSEGTASPPRPGAGSKDTGARRSQSYMDYLRHPGSRPSGEYNRAVSGSFLSARYDSKGEDQGDGDDFNGLECIRSPYSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CU85</accession>
    <name>A0A1C1CU85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein ecm33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ecm33</name>
        <name evidence="8" type="ORF">CLCR_08565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CU85"/>
    <dbReference type="STRING" id="86049.A0A1C1CU85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_08565"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_06081"/>
    <dbReference type="eggNOG" id="ENOG502QUZC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12454">
        <property type="entry name" value="Ecm33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008651047" evidence="7">
        <location>
            <begin position="20"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT52053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="403" mass="41724" checksum="232A6EBB88579E5F" modified="2016-11-02" version="1">MAFSKVILPSLALASSVFAQTRDICDGPSITIVTSADADQIAGCETYDGDVIIDPEAQGIIAINGVQQITGDFTCVNATLLTSITSDQLNTIQGTWHLEDLTILSNLQFSSLTGVNTIEWVGLPALQSLNMAQGIQRANSVYISNTQLNNINGIELSAVATLNINNNPYLTDVNVNDLKNVTQALSFSANGRDLAISFPNLESAANLTFRNVSKIDMPSLATVGGSMGFYSDTFKTFSAPNLTTTGGTLAFVDSPSLTSFAFPALTTIGGGFLVANNTNLKSIDGLPKLTTIVGALDFAGTFNSVVMNKLTDVRGGSNVQTTSTNTTICDLFDSAHENGVIKGVNTCLTSKANPETNPTATGGGTASTGTSSGDSSNDNAAVTFGPATPLAGLGALLAAIFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CUS7</accession>
    <name>A0A1C1CUS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative steroid-binding protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MP3</name>
        <name evidence="4" type="ORF">CLCR_09180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000009">
        <property type="protein sequence ID" value="OCT52220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CUS7"/>
    <dbReference type="STRING" id="86049.A0A1C1CUS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09180"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05937"/>
    <dbReference type="eggNOG" id="KOG1110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="32"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="131" mass="14879" checksum="FC90942758DC4B77" modified="2016-11-02" version="1">MTDPTSPSPYSENKRFEPKVPVELSPPKDDEITLEELAQNDGTNPERPTWVAIKGTVFDVSKNPAYKEKGQYHVFAGKDPSRGLALSSLKPEDCVSNWDDLDDKYKTVLDEWYSFFSKRYNIVGKVSMSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVD3</accession>
    <name>A0A1C1CVD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CLCR_10269</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10269"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03856"/>
    <dbReference type="eggNOG" id="ENOG502QWM5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3364892at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF26">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="150"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT52460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="430" mass="48230" checksum="70F89D88FE5C044B" modified="2016-11-02" version="1">MSSLDDDPTDFEGVLPVIPPDSLPVYKDTRSNAATGASAAGVRAFTAQAVAFYFRAPVKAFFRTRVDYLAFAKSISPAAQSGGWSWRSTTPGLLANAIRVYGWRFVPEQLAPPLLANVAVGAALYTSYLQILAKLHEPSAHAKKTVYPPPSPQSTFLAGFAAGTIQSVVAAPLDALQVRFEQRGKKYEDKTMWEYGRGKLREIGLRGIFAGYGLSFLKDSFGSGVFFCVFEWVKAQGYYGFVKWWYRGTGEVEFFANTGNEGGRRNLVTGRDAPRTNDESNRRVVKPHYAIEPGFLMLAGIAASITQQVVLYPLSTFQTLHYERLEDLDKKAITLQNSQETPFARRGRMLRAYYHAYQETWKQARTQAVAQHGMRNWLFRGFWWFTIRQIPSTSAGLVIFELVRRKYGQEGLGDEVRISGREGRYDILLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVD9</accession>
    <name>A0A1C1CVD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable acetate kinase</fullName>
            <ecNumber evidence="5">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_09984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVD9"/>
    <dbReference type="STRING" id="86049.A0A1C1CVD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_09984"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03884"/>
    <dbReference type="eggNOG" id="ENOG502QSJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67445at2759"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="217"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT52487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="476" mass="51801" checksum="AB53F59197F8DB38" modified="2016-11-02" version="1">MSAVILSINAGSSSLKTTLFVEEQTEAGRPDLRRLASAEISSINSPPARLKYLRGSYKDTSEVGEITDHKQAFEHVLNAFVSDSEIPEVSSKDDIDYTAHRVVQGGNFEENQFITKKTFDKINKLSDLAPLHNASAVSLMKACHDRLPNVINVACFDSGFHHTMPDYVKAYAIDQKIAKEKGLRKYGFHGLSYQYITRTVADFLSKPQSATSIIALHLGSGASACAIKNGQSIDTTMGLTPVSGLPGGSRSGDIDPSLVFHYTSEASALSPSSTKDLHISTAEEILNKQSGWKALTGTTDFSKIAVADAPDTHKLAFNIFVDRIVGYVGNYYVKLGGSVDALVFAGGIGEKSAYLRQVVIEKVSCLGFTIDDEKNKRGTDGNDVTEIGKGEAAVRTLVVETDEDFRFRRLNTALQLLFMAAAPMRLARITAPKRSHMGKSLGFTNPTQYRRDPVQPQGMHGVICHSLARILFMLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CVL0</accession>
    <name>A0A1C1CVL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CVL0"/>
    <dbReference type="STRING" id="86049.A0A1C1CVL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10416"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03955"/>
    <dbReference type="OrthoDB" id="3650366at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41163" checksum="852CAAA59388735A" modified="2016-11-02" version="1">MSDANCHRVLLVTYPRTASNLLIRILNLPDQLKVYTPNALAGYLLTPAAQVIRDSNASAAPLDSWPNGLADRLKQIYRDGFVELEKTASKGAELGRAVFVKEHIQGLLHPLAQQRFVFGNANGKVAAVKSEVVEPWDFSTTGGEIGNYSALNDTVLADEMLKSWKPIFLIRHPALAFPSFYRVFRVLEGDEDDDPSGGRERWLDLYLTLHFTRRLYELYCAQGGAGGKEERSPAKTADEGEAHDGPRSQQHLPEWPIVLDADDIIASPVIVERLARRIGMDVSNLKFQWDAMPVEERKTMSPLMQTMLSTLLASDGVQVAKAAGQVVDVGVEKKKWETEWGESKAQKLERWVQAAMADYLFLRAKRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWC0</accession>
    <name>A0A1C1CWC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Aquaporin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">AQP3</name>
        <name evidence="13" type="ORF">CLCR_10328</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>glycerol(in) = glycerol(out)</text>
            <dbReference type="Rhea" id="RHEA:29675"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWC0"/>
    <dbReference type="STRING" id="86049.A0A1C1CWC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10328"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04100"/>
    <dbReference type="eggNOG" id="KOG0224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000027">
        <property type="entry name" value="MIP aquaporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT52750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="353" mass="38903" checksum="7EB3CF481203A748" modified="2016-11-02" version="1">MALEKESLSSTPPATHNEHGIFHTPHEYRHTTVDGVAAYAEHGPLVDHKVPQEDVVESEPDLAWSRIRHYMREPFSEFMGTFILIMFGDGVVAQVVLSNGTKGDYQSISWGWGLGVMLGVYTAGISGAHLNPAVTFANCVFRKFPWRKFPAYMVAQTLGALCASGVVYANYKSAIDVFEGGANIRTVPGYSDTATAGIFCTYPAPFMTKTGQFFSEFIASALLMFLIYALKDDGNLGAGNLTPLGLFFVIFGIGACFGWETGYAINFARDFGPRLMSYMLGYGPHVWTAGGHYFWVPMVSPFFGCTFGGWLYDMFLFTGESPINTPVVGLMRFLKPNRSTWSNTYVPQQTSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWF9</accession>
    <name>A0A1C1CWF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PS Dcarbxylase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_10585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWF9"/>
    <dbReference type="STRING" id="86049.A0A1C1CWF9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10585"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04178"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT52834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="299" mass="33087" checksum="F330DCB819F9D7BC" modified="2016-11-02" version="1">MGSYVMDRATGEKTFEQVSISVRVGMHLLYYGSRQMQHCCTSSGYKRSAGKQHVKMGRAYYSPEKQGAHPAHVGDEEAGPGALLDLFNEFFAREVRPNARTTRARARGRARHVVAGRLSLDGLPHRPPRDQVLGQGIFGFTLETLLGDTHLAEYFDRGQSRRSRGWLRRTTTVGMRPSRGRSIMSRSSPARYYTVNLQTISQEGTLNVFAANRRDVLVNAPTPVTGNKVAVVAVGAMLVGSIKWNPGMEEPGKTMKRGDLSGARSSTEAAPSSWYIPKVRWCWMKIWSGTATTISARPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWQ8</accession>
    <name>A0A1C1CWQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_11062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_11062"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT52868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="103" mass="11390" checksum="357FED3CE147ACFB" modified="2016-11-02" version="1">MSQLASAMENGRVFKGVEVIQGANQGEHLSKNERDKCEESNYCIQIRVRAAGPWSVVSYSRSTVDGVIDSEGRLGKLREWERAAKLRDGRAAARIVAVVVGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CWV7</accession>
    <name>A0A1C1CWV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT52955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CWV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10789"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04296"/>
    <dbReference type="OrthoDB" id="4148081at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT52955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="228" mass="25472" checksum="3E8141595AF4017E" modified="2016-11-02" version="1">MLAYTQTRSCSFICSIQKSPDIHRGRQTKAGTFLSTEYCARKTLSNTQYGVLGGNTPPSAERWTTSSCSRRLDLPQNLQRAQRGSFLRLSSILFPFLDLLPFLRRIGLNSHNPFTPSSEQAGRMPTTDSVLYLEPSLQKRANMGRFMTTILSCLHNLLIQVPQNGYHNISRVVQPQIRSLSDSFVASSSVRPAAGTKKGDIELQSMKPKKMDTAPLRTEGQHQTVPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX22</accession>
    <name>A0A1C1CX22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PXA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_10173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX22"/>
    <dbReference type="STRING" id="86049.A0A1C1CX22"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10173"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00095"/>
    <dbReference type="eggNOG" id="ENOG502RYEC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5582218at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="103"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT53123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="452" mass="49310" checksum="9A584A99DFC95278" modified="2016-11-02" version="1">MTASSSSPSRPPFPALATKASSTAQSSQLTAVADSKLTSGSRSASQRPPQARLRQDAPVPDPTSERATLSLIRRTLVADGSNGADTRLSPAPIEGILPPLTSSNDVDVQLYAIVAIVIKDFVNSWYSKITPDRAFVDEVIQIIAHCSRALEQRIRQIDVTDLVLDELPVLVERHIHAYRTATTAQAALQYGESPRRIYHALNPHPALDPSLPPEQQQVYESAYRQLLIQGALAVLLPTEDLANACLRTLVSDIISDLILGQALAQKLCQPWFLHGTVSKVVEIVTSRHAPSADDKNILQPEGRQSRLEKFGLLSSNTPAQQGNSSAGHQSLLSVWCWRLLQYAFIAYQSARFILVGLAHAHRLPRRSRHHQLDGSTASPSSTKPPLSSARHASDPGARSPRAVINYRFFSCISAMLDLTVRMPWLASSLGFWQHILSTGPGRYGAANSTLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CX39</accession>
    <name>A0A1C1CX39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial substrate carrier family protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mcfG</name>
        <name evidence="12" type="ORF">CLCR_10521</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CX39"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10521"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04426"/>
    <dbReference type="eggNOG" id="KOG0762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="98"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="194"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT53094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="315" mass="34427" checksum="128347D8B2064412" modified="2016-11-02" version="1">MSADFWASYFSGAFGILIGNRLDVLKVRAQASTNTGDAVSVRTREPENAVKRFTALFRGAAAPILGYGALNSILFLSFNRSLSLMDPGIFDYTKLAGVDLSKIWVAGAIGGLATFVVSAPSELIKCRAQLVIDGQGSSYHVLKDVWKHGGIRGLYYGGTITAFRDSFGYGWYFWSYELTKRLLLSRQADPFVSPTAADVLISGGIAGVVTWVSIYPLDVIKTRLQTQPSWTVERQRLLPGSEMAAHREQSSLAIARQVWRSSGIGGFYRGVGICSLRAFIVNAVQASSGTHTKGSWNSSEEVDDAPYQRKAVYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXA7</accession>
    <name>A0A1C1CXA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Acaa1a</name>
        <name evidence="13" type="ORF">CLCR_10193</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXA7"/>
    <dbReference type="STRING" id="86049.A0A1C1CXA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10193"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00071"/>
    <dbReference type="eggNOG" id="KOG1389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF12">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="37"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="299"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCT53098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="421" mass="44845" checksum="CB2CE7A826E358BD" modified="2016-11-02" version="1">MSAQQRLEALSGQLSSTSTTTHAPGLKKILEKNPDDIVITCATRTPLTKAGKGGLKDTPTDEILIHVLKAIKEKSKIDPNVVEDVCVGNVLQPAPGFIARSAVLAAGFPVSTAANVVSRFCSSGLLSIQTLASSIAIDAIDVGIAVGIESMSTNRDAPPPMSEKILSHPVAKDNIQPMGWTSENVARDFNVTREQQDKFAELSHNRAERAQNEGWTQDEITPVTTKWVDPKTKEAKTVTVDKDDGIRPGTTYAGLQKIRSAFPQWGPTTTGGNASQVTDGAAAVLMMKRSTAERLGQPIVGKYVKSTTVGLEPRIMGIGPSLAIPKILQKTGLTKDDVDLFEINEAFASMYVYCVNELGLDINKVNVRGGAIAIGHPLGATGTRQVVTLLSELKRRKQKVGVTSMCVGTGMGMAGVFVNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXN3</accession>
    <name>A0A1C1CXN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS7m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_10289</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXN3"/>
    <dbReference type="STRING" id="86049.A0A1C1CXN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10289"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00243"/>
    <dbReference type="eggNOG" id="KOG3291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9972728at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14868">
        <property type="entry name" value="uS7_Mitochondria_Fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000006">
        <property type="entry name" value="37S ribosomal protein S7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047988">
        <property type="entry name" value="Ribosomal_uS7m_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="9">
        <location>
            <begin position="205"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT53279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="375" mass="41275" checksum="2C7380F9B58BEBE9" modified="2016-11-02" version="1">MITFLLRTKITPPATMAPRVSFLTARSVVFRPKPVIPQKRIAPGPAFRQQQRAASDDATTKHDSNEFRGANESQLPHVTQEAAAIDEITGNTPPDIEQGTPVQEILQRDKDAQEKAPEVLKQDIKNKSSNGTNKPSASRSFSTSARRNSLELQPRSGSDGPPPDTAQFQGTRIMGLEYPDAGLGHKFPIPDLKPLGKGVNFKKRYDPVVEQVTRSLMKDGKLSRAQKNMEHILDALRTSPAPPSNSELITPLPIQSLPLNPVAYLTAIIDSVAPLIKIRQQRGLLGGGASMPIPVPLRLRQRRRTAIQWILASAEGRREDKFADRVAKELLSVAEGRSSSWEKRARVHKMAISARANIKAASMGRRVRSKSIRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CXZ5</accession>
    <name>A0A1C1CXZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">p-loop containing nucleoside triphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CXZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10856"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00379"/>
    <dbReference type="eggNOG" id="ENOG502SPN2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6118920at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NadR/Ttd14 AAA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="198" mass="22184" checksum="E49F34AA8A60DFA0" modified="2016-11-02" version="1">MEGSRSIYIIGAQCTGKTTLVEDVAVALQSHGAKPVTTIKELARGILNTANITRDDIRAGNAGAMEFQKLVLGAQLNEELDRERRGLIVSDRSGIDPIAYATLYGPPEVARELLESDAWRVLREKMRKGLIVLCEPVPEWLFDDGTRLMPADDAEWYELHTVFISLLQQTGITYEVLPATCTSREERVARVLERWRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CYC9</accession>
    <name>A0A1C1CYC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CYC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10217"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00427"/>
    <dbReference type="OrthoDB" id="4150903at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="454" mass="51000" checksum="0B24C6FDBC31CA88" modified="2016-11-02" version="1">MADQVNKKPSFAALRKWYQKRCRSVERNVQSESQHSATQIQDFLAHQPGAEYRQTVQRKPRVESDLHEEAQRKSQYLEFCHGRSELDSTPPRASVSTVSLPSTATTGSTAGVAQQPARPHQSLPRPRPRARPVVEGPEDFEQFRSDLRGRVELESTVARAQKQPRPQPKSFAIDLTQAQLAKEQLHAGPKAKAFKAFSGEPVEKGLEKIQAYPGVPKRKPVGYIPPTLQPGYVNGVPPVLRACHSITNLALPQNKPSESAATATTKNYSYPLVDFHQGLFVNANLSEASLSSRYQDPRIPAMEFASRGLADEVNAELTRLRVPDEKEVIRPKSGVPDEKEVVRPKSRAWMSPGSPLNQNAYELEASAPGFPILQAKAVNVRSHTPQIVRVTKRQELETASPVSPLSSDAGKVNFREYNWPRFVDKEFVDPAEEHSRRYRYRRREVLKERDRSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZ16</accession>
    <name>A0A1C1CZ16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_10835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT53793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZ16"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10835"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00720"/>
    <dbReference type="OrthoDB" id="4150099at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT53793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="191" mass="22397" checksum="135AA53DBE6B820C" modified="2016-11-02" version="1">MVDSTEKQESTPPGESVIDQATVEAESAAPSKARPKVKSSTTVRSRPRRSPIRATKVQQLRLIRHYIRRFCRYFGSFGRMKALNVEVRRRAVHSRYTDLRRFHSDYFLKYLELCERTTPYLAGGIRDDLAKFTWGQYHWWPKCKDLPTQSQRREMVDWAVEQLAERDFDNKSFMNALDDFCDAGWDRPLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CZX7</accession>
    <name>A0A1C1CZX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_10254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000008">
        <property type="protein sequence ID" value="OCT54028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CZX7"/>
    <dbReference type="STRING" id="86049.A0A1C1CZX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_10254"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_00926"/>
    <dbReference type="eggNOG" id="ENOG502SKUZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF53">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="85"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="344" mass="38979" checksum="A220037360C8E6AA" modified="2016-11-02" version="1">MPFKNLLSDIKSQVKDLQKQGQQFLQQQQSPSQSQSQPHHYQQQQQQHYPAQYQQPPPLPQSTHPNFQAQGSPPGQQPLPPQPKVYWQPRFDPATPISQEWEHKLGNNNGWGNNEKQHYTAEGSNSFYTPNHLLVLRAISTPSQPDPAKKYTSARLVSRQRLGRPSGSLVASLSLPCASGIWPAFWLLPYEPFTWPTDGEVDVAETWNGDAVNHSCLHWGFYSPEDKAKHRVVATPVHGMQTGRPVRFEFAWHQDGAGPGGRMVWWIDGQAVMKAPIPHDMNRPLADFVVLLNIAMGGNVCQGQVPREGAYDFVVHEMKMLEEPDGGWARFERDWAWVREGDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D139</accession>
    <name>A0A1C1D139_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D139"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00965"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01750"/>
    <dbReference type="OrthoDB" id="4160564at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="145" mass="15099" checksum="8CDDE2D0841A6048" modified="2016-11-02" version="1">MVTATTEDKVGEKIAFVMRVLKHTEMSKPNWKAIAAEEGISRSGNAQQKFRKSVESLGYAFVNDQIVDLKDGDDGAGGASAAATPGTKTGTTTTPTKKRKSPAKKDKETNGGETPSKKSKTTLPAPAGGGDSGEAEATKAQSQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1C9</accession>
    <name>A0A1C1D1C9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_00975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000004">
        <property type="protein sequence ID" value="OCT54511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1C9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00975"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01768"/>
    <dbReference type="eggNOG" id="ENOG502SG6B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5387214at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="166" mass="18227" checksum="D891860FE05D24DE" modified="2016-11-02" version="1">MTTPTDATELTEQKPAATHEHPKLEFDPCSNAKFTSPFYLYKHDSPRPSFDVAKSQDPVHVSVNDLKDLEAGSVNLSPSISQEKRDAQNAATTSRLTFWKRQKQCMTKPKQRGCAWFSRLSPRQRIVVKILIGLLIIGAAVAIAIGVSIKVGGGVYKSNNTTTEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1P4</accession>
    <name>A0A1C1D1P4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_03047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1P4"/>
    <dbReference type="STRING" id="86049.A0A1C1D1P4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03047"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04779"/>
    <dbReference type="OrthoDB" id="5430713at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT54672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="273" mass="29118" checksum="808096D8CD09F206" modified="2016-11-02" version="1">MVQVATVSPPVGQFVIHTLLQIAGFAVAIAFGVYAVRSVHAAVLANSFSREANNFSREAIQQAFAANQLALLATCLQAGNQTENRDITDICSRIIRGAAADLLSSAASSLFPDLPPPPSPSSSPDDSSSTLSPPTPTPTPTRSPLPAPTGPSTSASRSSVSTGAVAGAVIGSALLVATVSVTCIYIRRRRRRRHRRGHSSRRHDHDDSTTTPTPPPPPPPATRRRPASSFVSIFREVFMNSTMTSWTPNVDGELTTTRDEERGGQTERQQREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D1U4</accession>
    <name>A0A1C1D1U4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D1U4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03218"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="85" mass="9984" checksum="F380E4D42F04A446" modified="2016-11-02" version="1">MTSTPLFEFRQRDARETQSFYDDTGVHHALLRSDRRTTKTKHRKRTPSLVIGRTTAQMMPRFAQRRGRRAYRLPLPVDGKQLVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2T7</accession>
    <name>A0A1C1D2T7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_03159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT54948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2T7"/>
    <dbReference type="STRING" id="86049.A0A1C1D2T7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03159"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT54948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="169" mass="19337" checksum="846A2A3FAB882CA7" modified="2016-11-02" version="1">MLHRRIALSDFRDSRAHARAGEKRQTRNEYLLRKAFEKLMGESCAVSSGSLKLDLAVKDDFSYHDEGDQFHTQPYETINPLRLYQNVYPVLCQLSQPRRHGWCSILPMDGLLGNAYGTELRARFEHPLGTEDTDPDGSIFPIRSELTGFTIRVPSLFDGRHVRACNKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1D2Z1</accession>
    <name>A0A1C1D2Z1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein lifeguard 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Tmbim4</name>
        <name evidence="7" type="ORF">CLCR_03074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000003">
        <property type="protein sequence ID" value="OCT55111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1D2Z1"/>
    <dbReference type="STRING" id="86049.A0A1C1D2Z1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03074"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_05201"/>
    <dbReference type="eggNOG" id="KOG2322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT55111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="274" mass="31032" checksum="C4F16EB3EC7AF02C" modified="2016-11-02" version="1">MASNTKYQPAPQRDSFDEQHYTQAPPGYQAAGPSDVGYGTPRAEDDNVPDDFKFGGSVSEATLDIRMQFIRKVYTILTVQILLTAGLSSLSFFSQSYRTWIQSNSWMMWVSLFGAIGFMLLTFWKRKSYPTNMLFLAGFTALEAYSISVITSFYESRIVIEALVITLGIFVFLTLFACQTKYDFTSWMPYLFGALWILIIFGFMAAFFPHSSTMETVYGAVAALIFSGYILVDTQLVMRHYHVEEEIAASISLYLDVLNLFLAILRILNSQNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6A6</accession>
    <name>A0A1C1C6A6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_00660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6A6"/>
    <dbReference type="STRING" id="86049.A0A1C1C6A6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00660"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01013"/>
    <dbReference type="eggNOG" id="ENOG502SPUN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF131">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="35"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="361" mass="40391" checksum="ECFD598CBD90C778" modified="2016-11-02" version="1">MSQIPPEFLPHDSYVGEIYRVNISFICVNSVIIFVRLIVRAFMVKHVAVDDYLMVAAGLCADVFSALAIVGIRYGLGKHLYDLPQNSQLVDNTKNVIQASPVAVRLRVSANVQQTLWICQIMYATALMLVKISIVTSYLRVFPTTLFRRVMYALSASIIAVWICSILVTIFQCKPVRSAWDFTLARDCLNIVSFFYFTTAFSIFTDFLLCILPLPVFFRLNLPSRQKYIVSLLFAIGLFATVASALRISVLKSVNSLDVTMGSVSTMKWSVVEVGTGIICACIPTLKPLFKNFLPDKSSANRSRERSGPGRLEATGLNTPRLNTAHEERHELTKPTEGWTNFSRNTLTFKQGPMATTKNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6B8</accession>
    <name>A0A1C1C6B8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tachykinin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_00589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6B8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00589"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01032"/>
    <dbReference type="eggNOG" id="ENOG502SP01">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="70896" checksum="80B53649A2B2BED9" modified="2016-11-02" version="1">MALVPLGQGKVKPTTPLIIESEALASLPSKPNDSPPLITDFPCAERDSSCATECVDFHDVRYGQVPETMGRDSLRALDAVQWEGSVTLRRRADVLPRESESLTHDIDEGATDSSEDRGHARKETIPSKPTARQHAARKPHLKRAVKGRKHVHGVRPNKAVSKKEKHDESLPVVRYNEGPSWLLELDGEEINPLLPSPFPNDLVRRHMHSLPEVLAKLVSKAALSAPYGRAFSSDLMASLSMHPAQLHAMMFAVMVHDRIQQGISNPTATELMVGTEAIRYLNKEISSPDPERALSDSNIWAVLVLAYSGREDKLRPAQSYPRQSFLRELQSIHIYLKMDIVIEHVLGLVKMMELLGDLRKIKTPGIAQTVSWAGVMGAVRNLTRPIFPFVSHTATFVYEDGRLAVSQHEREAVAKDLGRLGAGFWQVWSLTAASTAASLDRLFEVIQDMADFTIVVENHASGRWIPRTSPEIIDQRNFVQHKLMSLHSEEELVVSGGLVAEDIDVQYETCRLACIVYSFLVVFPVPPVVGPFETLVERLKRTLQATDWTEFDGPRLRLHLWILIMGSIAAIGLPDRPWFLLRVMEVLEEVGMTHWKDLKALLKTFLWHPRTSDLDGLDIWKATQHADTPDLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6L9</accession>
    <name>A0A1C1C6L9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ARC15</name>
        <name evidence="6" type="ORF">CLCR_00717</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6L9"/>
    <dbReference type="STRING" id="86049.A0A1C1C6L9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00717"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01112"/>
    <dbReference type="eggNOG" id="KOG3380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT44185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="191" mass="19992" checksum="093353D8D04D3611" modified="2016-11-02" version="1">MSNINWRTINIDAYDPESAFNFPLSTLLPANLPAPSTSSESAQIGQQVRQLLRAGDSIGALQSALETAPFAGDEGAKQVHLTTVLEVLQGIRQSDVSRILAEMLKQPGGTALGDTLMKYIYKGMASGTGGAGGKGVSPQATGSGFSQIQSRNFGEGGGGQVMSVLLSWHEKLTEVVGVGGIVRVMSDRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C6Q8</accession>
    <name>A0A1C1C6Q8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_00575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000021">
        <property type="protein sequence ID" value="OCT44166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C6Q8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00575"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01096"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF17">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="139"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="535" mass="59826" checksum="7571B0DD46FC96B4" modified="2016-11-02" version="1">MRRNRPAQLINSCCDVCNMAHTEKPVNEKHSVDSERTATAVEDARPRKRSFVDVDVDKLSAAFENPLSGIPKEQLLEEVEAFCRDNNLAEHIDAFRRGALVAQSPGDTGGIVELTPEDRDVLMREQTHRWHQPKTLYWLVVMCSLAAAVQGMDETVNNGAQALYLKQLNITTDRFSPAMVDNLTGLVVGAPYLCCAILGCWLTEPCNKVFARRGTIFISCFIAAVASIWEGVANSWVNLFLARFVLGLGIGPKSSTVPVYSAECAPAPIRGALVMMWQMWTAFGIMLGNIMGVAFGGLAPDLGWRLMLGSTVVLPLIVCAQVYFCPESPRQVPSLLAQSVRLIVSLRWYIQHGHPDKAFRSFRRLRFTDMQAARDTYYTYVGVELERKAHKGKNLFTQFVELFTVPRNRRATWASWIVMFGQQFCGVNVIAYYSTTIFIESGYSTTSALLASMGTGILNWVFALPAVFTIDRWGRRNLLLFTFPFLAVFLLWTGFSFWFTNTKAKVGMVTTGMYLFEVFYSPGEGPVPFTYSAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C785</accession>
    <name>A0A1C1C785_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_05462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C785"/>
    <dbReference type="STRING" id="86049.A0A1C1C785"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05462"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07027"/>
    <dbReference type="eggNOG" id="KOG1341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF37">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="235"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="753"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="756"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="796" mass="88250" checksum="6FD35BFC9A68332E" modified="2016-11-02" version="1">MEKPSSSLPAGPERRKRQTVGQRAVAWVRHHVYQGVAGLSFIQWHYFYFVASTLVASLIFWGSSTPAKSVPYIDSLFLCVSAMTEAGLNTVNLSELNTWQQILLFLLIIFGSAIFVSSSILHIRKRAFESKFAELVEQRRKRQHRPRTRAFTLSRRDQVHSNGRESTVASGALRGRLVEAGPECPEYKDASCLSDRSQALEAPAETQAGLGPPHVTGTTTDDSHMGHIRFAESVPPVERTESRSRSMRHSPSFFEGRGVGARGLDNHPRNARPVEIHDATLDCAIDDKSAQPGPWVKKVHSYIDTAGGYLGRNSQFHHLSEKERRKLGGIEYDAICLLSWLVPVYFALFQLFGVLGVGAWITANRPHISSTNGLNPFWTGAFFAVSAFNNSGMALLDANAVALNTSYYCMLTLSLLILAGNTLFPPFLRLILWSFSKVMPENSASAEWARRRRTVQFCLDHPRRVYTNLFPSAATWWLVASVVVLNAVDWAAFELLNIGNEVVDSLPTGFRIVAGLFQAFAVRSGGFYIVSISGLRSGLLVLYVLMMYLSAFPVTMTIRNTNVYEERSLGIFADELPLYQDNEGITSQKDKKEGLLTGLRRTLTMTHGGHATQNPTWSREDFIRLQLRSQLGHDLWWIAVAVFAITSIETGQFERDPVNFSTFNIIFEVISAYGCVGISVGVPWNNYSFCGAWHLTSKLVLCAVMLRGRHRGLPVSIDRAILLPDESLAWAEEEDAHKRTTSFTSEVAMRSGEVLRPATSATASTNAARRPRSASSGAPGPSIHVDDHARGAEHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7F7</accession>
    <name>A0A1C1C7F7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_05875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7F7"/>
    <dbReference type="STRING" id="86049.A0A1C1C7F7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05875"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07147"/>
    <dbReference type="eggNOG" id="ENOG502S5NV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT44465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="436" mass="46764" checksum="E6843E42FCA4CCA8" modified="2016-11-02" version="1">MQHSRPPQLPCCSSFKKHRSSISGSRFTIEHLTLPKPLAVPAWASLPTPPMSGSPPPERPAEPPQIAGRRRKRSHTPPVTTTATTLAPITPLDTSAARPSTLLRGGETLGELAVQHDPYALNYPPPPTTYQAASTLLSSSTSVQDPRFALSPISPRTTRKPKAHVASACVNCKRKHLRCDASRPCRRCVQSGKEDTCRDVEHKKRGRPPLKAEDQANVARYQASTAHYPSSSPAGAAPLGPPTRFPTFSQGSGLTPLLPSPAPWFRSQQQGMPAYYPTPVQPSISSSLATAEGSFVPASSGPYGIRPPILPGQSPSPYTSRAESTPQGTAYTSYPFTPQGQPERSYYSNPIFPPQIPSTLPSEQLAPLQTSSALQLPPINFPAPSGLIDPAIVQQPAPSIRPSPRGGQESRDDGTQEPDPKRPKMDIKGILGPRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7I8</accession>
    <name>A0A1C1C7I8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_06397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7I8"/>
    <dbReference type="STRING" id="86049.A0A1C1C7I8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06397"/>
    <dbReference type="eggNOG" id="ENOG502SBQZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5415522at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="80" mass="8447" checksum="0A16EE3D685B3384" modified="2016-11-02" version="1">MGKESGNSGSSSYTPYTINNSGTNSQGNSYDNRSQPGGNAYHYSNSNGSYYYSNANGSSYYNSGSGSSTYTAPNGNTYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7K5</accession>
    <name>A0A1C1C7K5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 24" type="primary">cprA</name>
        <name evidence="24" type="ORF">CLCR_05551</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7K5"/>
    <dbReference type="STRING" id="86049.A0A1C1C7K5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05551"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07158"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000111">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="78"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="287"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="84"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="461"/>
            <end position="464"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="479"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="496"/>
            <end position="499"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="624"/>
            <end position="625"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="630"/>
            <end position="634"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="666"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="704"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="OCT44476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="705" mass="78237" checksum="2088280DC1BF9218" modified="2016-11-02" version="1">MSTEPEAAPIKLPAMAQVDTLDIIVLVLLLLGSVAYFTKGTYWGVPKDPYATSALNGSAAKKGSRNILEKMDESGKNCVIFYGSQTGTAEDYASRLAKEGHARFGLNTMTADLEDFDYENLDQFPEDKVAFFVMATYGEGEPTDNAVEFWEFMNQDPPSFSENSDEKPLSNLKYVAFGLGNNTYEHYNSMVRNLDKILTKLGAKRIGTAGEGDDGAGTMEEDFLAWKEPMWAALTQEMGLEEREAVYEPVFSVEEREDLSPETDTVYLGEPNKNHLENSQKGPYNAHNPFIAPIAESRELFTVKDRNCLHCEIDVSGSGITYTTGDHIAIWPTNAGLEVDRLIKTFGLEEKRHRVISMKGIDATAKVPFPTPTTYDAAIRYHMEICAPVSRQFMSTLAAFAPNEEAKKEMAKLGSDADYFKEKISSQMLNVSQAVSAVHPGPWSAVPFSCLVEGLNKLQPRYYSISSSSLVQPEKISITAVVESVRVPGAGHVVKGVTTNYLLALKQKQNGDPDPSPHGLTYAITGPRNKYDGIHVPVHVRHSNFKLPSNPSKPIIMVGPGTGVAPFRGFVQERAEQAKRGEDVGQTVLFYGCRRQSEDWLYKAEWDEYKKALGDKLTIFNAFSREGPKKVYVQHLLKENAKFINELLQQKANFYVCGDAAHMAREVNEVLGQIIASERGVDEKKAEQVVKSMRSSGVYQEDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C7R4</accession>
    <name>A0A1C1C7R4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_06444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C7R4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06444"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT44536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="119" mass="12993" checksum="63BA8276AFA39A04" modified="2016-11-02" version="1">MLSSAFSTATAGSPAELSNCVKHMTWALDQTGRTPNGNQVHVEHKSSAVPGGHINRQPNYNSPMWTWVGKRRNILTAQSIQYIFLGPSNRLPHGPRLKASAAGIGVDLPMKSQMQRNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C8M2</accession>
    <name>A0A1C1C8M2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT44809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C8M2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05455"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07483"/>
    <dbReference type="eggNOG" id="ENOG502SVYW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5401902at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT44809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="828" mass="89774" checksum="F5CD3CE844065E44" modified="2016-11-02" version="1">MTNHSTNSPAGRQRRYTVSRLLELAPQSRPTSFDLSKFTYDAARAGVVPPLGACVMSNRRTSSDRPRGWSHESGSSQDEVIVYQGNRMAKLPERQPTVPPSGQSAQKDEGFARFLKKHSSPTHQRVTTGGRIVPMEQRPPFFSLQHSSQDTEDQKKSVHEEVKATTKPTAAGLDQARPGVPGSSILQPQPQPFMPVSNGVMDAATFAAGTDPTVVASTIPLGLDATRMQPTYLQAVTASPFYGGMPGDPYSLMPVPSQMYPGSAVPFAGFNGAVGPTFSMPFIPNPQMLGFPPSCGITTTPTVPQPPSGSFDEHMLNESIELFQNLGEQLKALDRHRAMNDRDPYVVDQRKAIVQLRAEAKNQITYWSEKLGQDPHAMPKNSSGAPNGKLNVQATSYVPLRGDQAAETLSDTRGSSLKPNGISQGHAKPDFVVDSTRRPIPIVPPPEKLSTVQQGGRDGGSKSESVEVDEWGIRVGPAPPEIQRQQNEMLREIVRQASISPLGSSENAIVFTPQGSHVITPTTQPHETKEARTDTDSGTSDWLPTNPGRAPPTVEACYEVQLDAMRLPIGVVTKVRMPDGTITEVRGCGLKRPPSFEMDEFEQRYWTTKPKVTKEMFENFVEVRADGGKNAPADIATYCEFMGLESGSVPMGKSDISDKQSNESMHATKDLTNAQDMLREISGRGYSSTIEKSNGSGPRLSSLKLSSASSPPIWSRADDKVGWFANEHSRSGRLTGSETHSSKGISSVSVQKFHAMGRLPHVDGPSDGQRVSAVSMLAAASKTVSPQPAPRSVPSSESFYGSYGQEDRGVSVVSDDVFRTRMRQEESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1C9X9</accession>
    <name>A0A1C1C9X9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_05690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1C9X9"/>
    <dbReference type="STRING" id="86049.A0A1C1C9X9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05690"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07979"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="221"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="596" mass="69013" checksum="1FDC41464BEE5A6C" modified="2016-11-02" version="1">MRLIDAITRQLQWFDDDKIPKYAILSHRWEDEEVLYEDMRSGNGPRMKGYVKLQNACEQARQDNCQYIWIDTCCINKDSSSELSEAINSMYAWYQNSERCYAFLSDVQLPPGESVVGDDFERSVWWERAWTLQELIAPGQIDFFEHAWRHIGTRSTLLERISKTTGIHKNALLERRPHDFSIAQRMSWASRRKSTRREDIAYSLLGIFDVNMPMLYGEGMKAFVRLQEEIIKRSDDQSIFAWEASTEQPQLLAESPWAFRNCRDIVPCPIPHHRPSPYSLTNMGLEIQIPHIIWSLNTYLALLLCHDQTTKHHVGIFLGVNAGPGQHARIFLDKASIQYIRPERFIELELRQSAQLTYGTNVPTHVRQEELLRASPHSGKLLIRQIGWHWTGSLYGFHLGACYAWPRELESSEQLTVYARRWDSRTMTMELPDGSYGTAGVVVFRHPARSRNPCVAVKLGFDVEFRPVCLIWYHFPPPKTVDYRPLETLVAEEPQSPQELDKFLDSRWVGGDAQLDGSIGVSSTEFPGVTFDGLKPESEICYFTGTDRRLSKQRNSLLERTGLSVQFSYEMIPALRGRHGWVFKLLFEKDFRPIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA08</accession>
    <name>A0A1C1CA08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-1,2 mannosyltransferase KTR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">KTR1</name>
        <name evidence="5" type="ORF">CLCR_05868</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA08"/>
    <dbReference type="STRING" id="86049.A0A1C1CA08"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05868"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_07947"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT45307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="428" mass="49514" checksum="4AD18F03EDB86A61" modified="2016-11-02" version="1">MATGSGRYLRYILFAVFGIAILYFISTSSLPESAGSLTQGTTFGWDRSAESKSSPEVKDPAELVHLPQTDSATSSATDALPTLGVTTPNVVPTIPSELSPPAPGERVNATFVTLARNSDIWEIARSIRQVEDRFNRNYNYDWVFLNDKPFDETFKKVTSSLVSGKTHYGEIPVEHWSFPPWIDQKKAEAVREDMRRRKIIYGDSVSYRHMCRFESGFFFRHPLLQQFEYYWRVEPSVELFCDIHYDPFRYMKENKKKYSFVLSLYEYVETIPTLWDSAKKFIKAHPEHISPDNSMAFLSDDGGDTYNKCHFWSNFEIGNLDWLRSQAYLDFFESLDKDGGFFYERWGDAPVHSIAAGLLLRKDEIHFFNDIAYYHVPFTHCPTGDDVRLKLRCHCNPADNFDWKGYSCTSRFFDLNKLKKPAGWEAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CA80</accession>
    <name>A0A1C1CA80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_05992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000020">
        <property type="protein sequence ID" value="OCT45378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CA80"/>
    <dbReference type="STRING" id="86049.A0A1C1CA80"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05992"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08009"/>
    <dbReference type="eggNOG" id="KOG0428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="5"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT45378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="388" mass="41719" checksum="8295CC5C4E7069A2" modified="2016-11-02" version="1">MAPSPTIRRLLKETAELSSPSSNPNPAFFAAPVSDADLHEWHFTLLGPPSPSPYAGGMYHGRISLPATYPLKPPNFRFLTPSGRFEVNREICLSISGFHEETWMPAWGVRTALTALRSFMAEKGSAGQVGGLEAPADIRKRLAKESRSWKCEACGKSNETIMREWWDICQSAGVDMKGEEDLDLESLPEGMSLETRDPNAQRATQGGSEPQVRSQETVQQTQRPPDTVSHPTAAIVSSSPPSSSHPQTAPPPTSQTGSSSSLQLPSQSPFQHVPTPSAEAAQASAEAVLTPSDLAQPPNASSGTATHRRPLFSGFHNAPLAAANAAIAQNARPLTLQRDRDREQTITIDRAIAGVFLALCLMVLKKIFFPAGSGGVASSVDDFYLQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAR2</accession>
    <name>A0A1C1CAR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_01641</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAR2"/>
    <dbReference type="STRING" id="86049.A0A1C1CAR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01641"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03443"/>
    <dbReference type="eggNOG" id="ENOG502SPC9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650673" evidence="9">
        <location>
            <begin position="22"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="10">
        <location>
            <begin position="82"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="267"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT45532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="309" mass="33444" checksum="A7209C0F38AF3980" modified="2016-11-02" version="1">MARSITLVLYSAALLATSAHAQFGYGWWGGNNDRDGCPPWVSDCDDSDDNGSSDDSSSNGVTQGALFTDSAQFDKATRILIAHAVLASVVWVMFIPSLAILLRLNLKNPIVLKIHAVGQILSYVIYVVAAGMGIWLAQQLDPYVDVWSDPHPKLGLAILALAFFQPIFGAIHHSIYKKRAQNVDSGKPTKPPGRTAPGQVHLWLGRGLIALAIINGGLGIRLASFSPFQTDATSTKVKIAYGVIAATMVSLYLFFVVGFEIRRARSRSEEVDGSRREEVIRNKDGLPSYDESEESVGRSTRSGPSARTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAX4</accession>
    <name>A0A1C1CAX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01704"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03541"/>
    <dbReference type="OrthoDB" id="4161813at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="239" mass="26303" checksum="85DCB22434672BD1" modified="2016-11-02" version="1">MPLSPIEEEYTDAASPISDAATQVEDDWETCTLVGDDEPMTAPERPVSPPIPTTEGRQPYRRTPVMACDDDLYFGDIEVRLVPAIGRIVDLIRIYGAPHSPPPPTPVIRPTPSTDTARIPLFRLDGGAAPFTIGGVVHIRRGVAYICGPPPRIPAQRTPVGVEEEHARLTAQRQPLHAQPGLQVAGENHVDRARRGEYHTSMIPPVLGHNEPVDEFGVRLRRHMRYVRAFARSAGLDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CAY0</accession>
    <name>A0A1C1CAY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_01668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CAY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01668"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03511"/>
    <dbReference type="OrthoDB" id="4151761at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT45602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="248" mass="26248" checksum="824269750DDB2A70" modified="2016-11-02" version="1">MASKEPQPNNKSDLMTKDAMYLFELMRDSPQPILLYITPYAEKTGTKANTIVKRLGEIKKRNGLNIITTTSPPGEIKTHHAHAAAAAAATARPRASNPRQDGAKSTVKCERKPAAATKSTQMIDSNNKFGDLKAEESNSLSISSSTSNNSAAAPAPAAAAHGLPSPVASTPGTPPGKWTAGTFPPAATGHAVASTAGLSPPQMPFYMPQKRAFCHVEVEADADADAVTHYVKSEDHAIKKVKTETWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB11</accession>
    <name>A0A1C1CB11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrogen metabolite repression protein nmrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nmrA</name>
        <name evidence="5" type="ORF">CLCR_01593</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB11"/>
    <dbReference type="STRING" id="86049.A0A1C1CB11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01593"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03628"/>
    <dbReference type="OrthoDB" id="5356836at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF5">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="265"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT45733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="408" mass="46093" checksum="541B16AD3CF7C62A" modified="2016-11-02" version="1">MPNKSKTIAIVNGTGRQAASVIRAVAALGYAVRAQVHSLQGLVAEELAEFPNVTLFEGPLLNNQVLIDTVFEGAQIAFINTNPLGGDEIKIGKALANAAKKRNIQHYIYSSMPDHSIHNPHWPALPQWACKFTVENYIRQLGLPSTFVYAGIYNNNFTSLPYPLFCMDFKDNGRLEWRAPFHPDTKLPWLDAEHDVGPAVLQIFKDGPSKWNGHRYVCPPCLARFTEFSVLVLHHEPTNENDWNIGGRSSPFQERRELEADLDLTLHITRIALAFEMLTPIQVCQAFEQALERPCKYVFDKHIEVKVPVPNGYREQLAGIEILFGQYNAPYFPGPDFDYDTRRKGSNETITPGRNSSESRKAKPGKLTDEARSLWPAYRPIYEYAKEAFIVEEEANGKTWMIDKSVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CB68</accession>
    <name>A0A1C1CB68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spermatogenesis-associated protein 20-like TRX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000019">
        <property type="protein sequence ID" value="OCT45755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CB68"/>
    <dbReference type="STRING" id="86049.A0A1C1CB68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01448"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03647"/>
    <dbReference type="eggNOG" id="KOG2244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1923667at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 20-like TRX" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT45755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="737" mass="81328" checksum="0635F2982604324E" modified="2016-11-02" version="1">MERESFSSPEVAEILNTYFIPIKLDREVRPDLDDIYMSYVTATTGAGGWPLNVFLTPDLKPVFGGTYWPGPAPTTNLKQAVPHDEAPVTFIEILAKMKEVWTTQRERCLQSSSEITDQLLAFAGEGIHSHSESRAPETEPSSTDPPEPLDLDLLDEALTHFVSRYDATHGGFSASATAPKFPTPCNLTFLLRIGAAIAQPSTHTRFGFFSPVPGILGKDSCLAAARMSLHTLLAMSRSGLRDQLGYGFHRYSVTADWNLPHFEKMMCDNAQLLGCFCDAWALGRDPEILGTIYNLVEYFTNPKSPIVNPEGGWYSSEDADSRSSLAPLSNGAIADDRKEGAFYVWTLKEFQSILGDRDASILARHFGVKADGNVPAQHDMHDEFLTQNVLHINATPSVLAKEFGLAEEEVVRVIKSGRAKLAEYRKAKREQPRVDTKIITSWNALAITALARAANTLSSIDRHRAQRCQEAAEKAAAFIRREMYKESTGQLCRISSGSAQDKANIAFVDDYAYLTQANLALYDLGLSQPYLDWAVRLQSYLDEQFIASTTGGYFQCPRPRPSSPPEQIIRLKPGTDTALPSPNGTICTNLLYLSSYIQSQSPSQQSTTAESYIRHARATLDAFAVEILQHPFLYVTLLGALVMEQVGVKTIIAPMTTKDSELRRLKGWGRTVVKGIVSKVMICSQDGVCRALRREDLEDVDELEEDNPQEKDKAKRASTEDGPAMAGPVRESVSAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CC66</accession>
    <name>A0A1C1CC66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PNO1</name>
        <name evidence="11" type="ORF">CLCR_00506</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000017">
        <property type="protein sequence ID" value="OCT46052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CC66"/>
    <dbReference type="STRING" id="86049.A0A1C1CC66"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_00506"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_10370"/>
    <dbReference type="eggNOG" id="KOG3273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="169"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT46052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="264" mass="29092" checksum="22CBDFEF7FDFE930" modified="2016-11-02" version="1">MPAPTALQRAPAGLADSEPHDIPLPTTTHDEDQDLDIITEPQLQSSPSQKLSEPDSVMEVDEEGRPRFLPATTSSSSVSDPAIRIQSRKVPIPPHRMSPLKTSWPKIYPPLVEHLKLQVRMNIKSKAVELRTSKFTTDAGALQKGEDFVKAFTLGFDVDDAIALLRLDDLYIETFEIKDVKTLQGEHLGRAIGRIAGKDGKTKFAIENTSKTRVVLADSKIHILGGFQNIRIAREAVVSLILGAPPGKVYGNLRTVASRMKERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CCN6</accession>
    <name>A0A1C1CCN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycolipid transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_01317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CCN6"/>
    <dbReference type="STRING" id="86049.A0A1C1CCN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01317"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09294"/>
    <dbReference type="eggNOG" id="KOG3221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT46227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="218" mass="23934" checksum="E4C7A048E43B44D0" modified="2016-11-02" version="1">MSAAKIPAGKTWFDTHKVHFEDVPTAAADDGISTTEFLDASEATTTLFDLLGSVAFTPVKNDMLGNINKLRERQRAAPEGSATVQQLVKTELASKSHKATEGLLWLTRGLDFTAQALRSDLTTNGAVKVTEQKPAKELADGFRASYKNTLAPHHGLLIKPIFSAAMSATPYRKDFYARLSGEGTDPETTRQELERWVAALEKRVNILKAFLATKEAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CD33</accession>
    <name>A0A1C1CD33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_01279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000016">
        <property type="protein sequence ID" value="OCT46367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CD33"/>
    <dbReference type="STRING" id="86049.A0A1C1CD33"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_01279"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09163"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT46367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="309" mass="34036" checksum="67199717D492785F" modified="2016-11-02" version="1">MEYILILPSVPCYGTKPPLDPLHNHNKRTVAPGETLAKPNGCYDCVGDHEKMPVPVSFLSQASFATTLVASTIGTFIALSPPDAAAVDHKRSTAAAAAEDSLSSLGLTSSLFGKLAMAPLSLLSLHTALLALSYPDMPSFFLFPLLRHQGGRRRRRRNDGFNTKLLSWSSPTVIPLAMILMLGIPLRLVPYATLGRNFTFFLSAPDRLITTGVYAYVQHPSYVGLVTLVLGNVMLLGRTDGVMSCWIPPGRHDMLSRLAKWVFGPAGLSILLFAVWTRVVEEEIMLEREFGREWKSWHDRTARFIPGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CE43</accession>
    <name>A0A1C1CE43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000015">
        <property type="protein sequence ID" value="OCT46805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CE43"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02178"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT46805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="102" mass="11333" checksum="1D2F232B69C7FB26" modified="2016-11-02" version="1">MSHETRAWATHRQVQHPVLDRGGKRERRGTDGPLRLELAEEEWSSLGAITGKRSGGLLGASPLLSSCITKVVVVLMGEDASRTQFKGPAARRTQRRMSERMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEQ3</accession>
    <name>A0A1C1CEQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ribosomal RNA small subunit methyltransferase NEP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NEP1</name>
        <name evidence="12" type="ORF">CLCR_02552</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT46927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEQ3"/>
    <dbReference type="STRING" id="86049.A0A1C1CEQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02552"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02491"/>
    <dbReference type="eggNOG" id="KOG3073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT46927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="260" mass="28669" checksum="DDAD11F7CF1C0678" modified="2016-11-02" version="1">MATTSNEAGTKRKRSRTQSLPPPELPRLIAEQHVPIASTDKDTKRLIVVLSNASLETYRAAHSGKPGGKEEKYSLLNSDEHIGVMRKMGRDISDARPDITHQCLLTLLDSPINKAGKLQIYIHTAKGVLIEVSPTVRIPRTFKRFAGLMVQLLHKLSIRSVNSQEKLLKVIKNPITDHLPPNCRKVTLSFDADVVRVRDYVDTLGATESICVFVGAMAKGKDDFADAFKDEAISISNYSLSASIACSKFCHACEDSWGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CEV1</accession>
    <name>A0A1C1CEV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative clathrin-coated vesiclec protein (Bud7)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_02298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CEV1"/>
    <dbReference type="STRING" id="86049.A0A1C1CEV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02298"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02419"/>
    <dbReference type="eggNOG" id="ENOG502QSKI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000146">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000149">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="710" mass="79770" checksum="2696A6451544F210" modified="2016-11-02" version="1">MVTPAVPEIIEDEDIGLAVDARTESLPGLRELGPPDLVHLVKQSTKAGAKQTGVYHHVTGIDASSSASLAAYVNTLTFNPADKTHKVVSGLYCCYNAFSHLDMRVEVKIPGSVESYCVDERGDRRVATESLWLETFLCAVLRAYSYSDNGSGDTIKKIIGVRRFNPIINTELEHRFFEAAERLFFSGRQLGSDPEIQIPNVVSNHLTAGLLKYIRTTGRYTSGINLFEKLRTKDVEISSLLARVLLDGDEEIQAVRLLHDSLEDVPMDYALLDCQASFCESKGEGEMALELAKQGVTAAPSEFSTWARLAEVYVDLEQWDLALLTLNSCPMFSYQDKDSPRMPEPSRVLLPILPESALDEIDEGQPRQGEPYDQVHVSLRKLQAATYQGTFLKAYSLLTRIAAAIGWDTLLKTRSQVFVMEEEYRSERQHSFTPKTPASKNASTIALSGTPNGDPKANGNGLDEDDESDDGSRTEEPKNNEDDLDGASSTAPTLNGGLSTNENAELKAGQSMEKPVPTIAAEEVKSGNDEPDPHHAQYPQFQNKRLCERWLDNLFMVLYEDLRIYTIWRTEMGQYRQQQMQYKKSAAEWEILGDLAERLHHTNEALEAYQQCLNIRFSPKAMKGLLKMYEKKGDTRNILACLIRLITWQYRWYSEFSPELFYSIRKLIEEEGAVKIRSIVQSTNLPQHVLDLTHEYCRLCVTFRSSGTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF57</accession>
    <name>A0A1C1CF57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF57"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02695"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="83" mass="9138" checksum="B76E1A026FE9F77E" modified="2016-11-02" version="1">MWFPNTMEGHLTQVVTDLGGFIHLASVHEILEDRIFRVDLGVIVPERLDSLGVTARDLTAVLDMALFLSRQGCALNVSEDGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CF79</accession>
    <name>A0A1C1CF79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_02569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CF79"/>
    <dbReference type="STRING" id="86049.A0A1C1CF79"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02569"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02257"/>
    <dbReference type="OrthoDB" id="3535423at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF9">
        <property type="entry name" value="EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT47174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28396" checksum="5DEE051A7021415D" modified="2016-11-02" version="1">MKLLIVGGTGFVATELIRQSLACREITSVVALARRPVEVPQNPGAEVDTSKLKSVVLRDFTKYSEDVKAQLDDADACICSVSDASGRERDRTLAVTPDKLKSLPWDEVVKVCHDYTMTGLQAIVEARGSAAKSTPLRFLYMSGDSAERDQTKTPRLMAQYCLLRGETENQVLAFAASHPGQVEVTVAKPGLILEPGNILHWLKSWLLWVVVSLPSITVVEIAAAMLDQVINGFEKDPLMNEDLVRIGQKALSETTTSSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFL9</accession>
    <name>A0A1C1CFL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_02408</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000014">
        <property type="protein sequence ID" value="OCT47272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFL9"/>
    <dbReference type="STRING" id="86049.A0A1C1CFL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_02408"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02161"/>
    <dbReference type="eggNOG" id="KOG1792">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="323"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT47272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="368" mass="39985" checksum="558CEFD1A3EA2D3E" modified="2016-11-02" version="1">MSTFAHDSDYAPQGGLSPETKQASQSNGVEPANLQQTLVDNASAAAQTIQQHPITQNLVNGPVAQSARNEAAATKSEFSNLAGSRSKPDYTASNASLPALPVTEATGLCDTELTHYHSFFYTLLSWKNKRATGITFASAIAFIFAVRYLPIIRYVIKLTWMSLGVVTIAEASSKALMGSSVASSLRPRRYYKIPKETLEASLDDLENLINFFVIEIQRIVFAENIPVTAVAFLTAFITYYLIKVVPFWGMALISTSVIFLAPLIYLENKEFIDAQLEHASHVIGQQTTQIKDLTAQHTSKGLESVKQYTGTAAAKAQDLVGTARQKIPSPTTGKAPIKENDFPSAPQTDLPDTNADVLQRETEPVPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CFU1</accession>
    <name>A0A1C1CFU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_03692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CFU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03692"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT47369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="208" mass="23413" checksum="98A38C1A658459F2" modified="2016-11-02" version="1">MDRPFSESSSDGLEYQIKHKPGGRQVPATKGRGEERWRQLYAYRGPDIATRELLTRDQIWLWRSQPAMFFQPQIEAGAHENYPDPDPEVELVIRSLHLGGFSAHIRLTSMLLSRFLGTPKAVISNDRLVHQRMSSLGRSKDDLIKHIELLSSGSRYDVLEKELGLGASFALASDISKSLFVPPSLSLVIKMVANEMFQMGQLPPEKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CGC1</accession>
    <name>A0A1C1CGC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Carrier protein YMC1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">YMC1</name>
        <name evidence="12" type="ORF">CLCR_03573</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CGC1"/>
    <dbReference type="STRING" id="86049.A0A1C1CGC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03573"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_01813"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="116"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="217"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT47573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="298" mass="32759" checksum="8A29048DE66348B1" modified="2016-11-02" version="1">MADAVEDIEKHEAETGSWARTAKDLFAGAAGGVAQVLLGQPFDIVKVRLQTTTKYPSALSCASSILQNEGPLAFYKGTLTPLIGIGACVSVQFGAFHYARRAFEEQNLRQNQPAGLSYSQYYLAGAFAGLTNSVLSGPIEHVRIRLQTQPHGADRLYIGPLDCIKKLSAHEGVLRGLYRGQAVTLYREAQAYGVWFLTFEYLMARDMKRNNVKREEISSPKVAFYGGLAGEALWIASYPFDVIKSKMQSDGFGKEQKYKTMRDCFSQTWKAAGWRGFWAGIGPTLVRAMPVSAGTFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CH95</accession>
    <name>A0A1C1CH95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CLCR_03619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000013">
        <property type="protein sequence ID" value="OCT47894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CH95"/>
    <dbReference type="STRING" id="86049.A0A1C1CH95"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03619"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_04459"/>
    <dbReference type="eggNOG" id="KOG2346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCT47894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="325" mass="35228" checksum="6500E96853FBF757" modified="2016-11-02" version="1">MATITSPRPDPVQRITSPSLPSVSGTPSSSVRPSLDLPRTNNPASPALQQSATPGAATAQRRNRAALRDYYNLKSKAASAAGGPEQRDGSRTASITSLGSDSTITSSAAVPESTASSLTAQLDDPSFNADAYVAELLKNASLRDILKTESALVSEIRTLDGERKALVYDNYSKLIKAVGTIAEMQKGMHKNGEQDRLAAALGKQKDQQSAGLDGVKAVEHKLDGLLRVIKGLSPGETEATRQIAQSKELRRQKETVRWALDAPHRLQSLIDDDRRDEAEHLHTSVLDLLRKWDGVEGVDELRQKCAKVMNQRSEHPNEEHRDDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHF8</accession>
    <name>A0A1C1CHF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Smr domain-containing protein C11H11.03c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CLCR_04311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHF8"/>
    <dbReference type="STRING" id="86049.A0A1C1CHF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04311"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08117"/>
    <dbReference type="eggNOG" id="KOG2401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="103"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT47950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="251" mass="28399" checksum="8F2BF17CC59CE2C9" modified="2016-11-02" version="1">MSYEMSTQHGTRVGARPFNHNQSQAAEQEYDRLRNLARQEASKRANCFQRSQQAYQDGDGAAAHALSQEGKEHGAKMEMYNKQASEFIFRENNAGGRVPADTIDLHGQFVEEAEDILEERIRYAQSHGQTHLHVIVGKGNHSANHVQKIKPRVEQVCQQLGLQYSTEENEGRIYVKLDGSPVEQHDINGWGGYQHYPGHQPGYSGGQQEQQYHAPPQQHQQQHGQYAEAENVTKGFLPRLINKLLRMLCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHI1</accession>
    <name>A0A1C1CHI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein END3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein end3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Endocytosis protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">end3</name>
        <name evidence="25" type="ORF">CLCR_04155</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the END3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT47973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHI1"/>
    <dbReference type="STRING" id="86049.A0A1C1CHI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04155"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08140"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000339">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein END3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF174">
        <property type="entry name" value="GH06923P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15 21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="23">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="24">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="23">
        <location>
            <begin position="145"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="307"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="341"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OCT47973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="412" mass="47307" checksum="930CCB509821B714" modified="2016-11-02" version="1">MSGTKRIEKWEIDRYWEIFSSLVQQPASPSSRLTNQAAANVLRNSQLRDDQLERVWDLADVDGDGELDFEEFCVAMRLIFDLVNGEYQDVPKSLPDWLIPESKAHLVQANRALTGHSQAQFERIEDDEEDAGLKDGFDWYMNPGDKRKYEEIYSANKDRRGEISFESLHTLYGSLDVPDTDVRSAWNLVNTSGRNSISKDACLAFLHILNYRHEGFRIPRTVPPSLRASFEENQIDYQIDSVRNRPNKYDEDTSTGRKAKFGDAYLSRIGGRGGSAYEPKGTDFSDVVEDEDLEKVRLLRELRELEAQHDAATAASDRRRKQKTENGGPRQPGKTNWTLVKREAQQMLEYKQRQYVALNSEDANKAGGDLKRLRDDLALVSEQIDGLESHLRKREAELESIRREIENEKSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CHU6</accession>
    <name>A0A1C1CHU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">(S)-1-Phenylethanol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ped</name>
        <name evidence="6" type="ORF">CLCR_04320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CHU6"/>
    <dbReference type="STRING" id="86049.A0A1C1CHU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04320"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08238"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT48080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="263" mass="28418" checksum="1B0A2AB011F1365E" modified="2016-11-02" version="1">MEQEGANIRPTRIYRDKYAEQVVLVSGAARGIGRVTATLFADQGANVVLVDLDEQELKRVEAQLTSDGRNVTYRVANLASEEHVNSMINEVVSSLGRIDVLVHIAGIYPFCPLLEQSTPEYKKVMSVNMDSSFYLTRAVLPHMQKAGYGRIINTASGTASHPEAGLAVYAASKSAVVAFTRATATEAGPGVTANVVAPGLVVTETTWSSPHARPIFDKAVERQCVKRYGQPKDVAQMISFIASPEAEFITGQLFHVSGGMIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI26</accession>
    <name>A0A1C1CI26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_04174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI26"/>
    <dbReference type="STRING" id="86049.A0A1C1CI26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04174"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08269"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="136"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT48117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="394" mass="43227" checksum="49D319546312331D" modified="2016-11-02" version="1">MAPRPKKEKIVLSNFQPSRSFLETVSTSSLNYRECALQEIMALIAHDPDDSLDEYLATALYYGATESEIQNVVYQSSFHFGPSKAITTRSRVVASLQSLMGPLHHALNSTYVEKEVSVGDHHTVVKDSNPHSQSIPIVLIHALALDRRMWDAVFARLVATTAGSSSSSSIRVIAYDMRGHGYAAHAPHARSLTQLASDLHRILDALKIAKADVYGQSYGGAVAQYFALAYPHQTRSLGLITTAGEAQPSWITRATRAEEAQSVGPLLPETIIRWFTPEAIARNEWGVRYARSCVERISLSDWADAWRCMSQLDSLQSLSAGKVKCPVLLACGVQDASTGPKWMTRLKEACEAGGNTEVVYREIDPGVHMMALEQGEVLAGEILAFRRRVDELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI37</accession>
    <name>A0A1C1CI37_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NAPEPLD</name>
        <name evidence="3" type="ORF">CLCR_04152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI37"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04152"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08320"/>
    <dbReference type="eggNOG" id="KOG3798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF27">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="109"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR038896-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCT48170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="414" mass="45993" checksum="2B6ABD1409D687D3" modified="2016-11-02" version="1">MSTFSSNASRPAHHANSSATAFVNPWPSASAPTWGELAQSSFPLGLYKDEHLRHEKARELKVVKPDWGKASLKDRNIDKATSVIGTWLGHASALVEIPPIDNIEQKSLWLLFDPVFSMRAGPTVNNGVARFKTAPCQVEDLPGCDAVFISHNHYDHLDAPSIRAIVQKFPQAKYFVSLGIKQWMSSMGVPVEQICEMDWWENREYCPEDFGIDTRPASTNQINFRFSCVPAQHNSARSPIDQGRTLWCGWVVERFIRTQDDSSESKATRKGSIYHAGDTGYRRTSRSDVVCPVFQEIGERFGAFDLSFIPIWRGGTLGFFSSWGLRLSHQDFPAAHHASPADAIAIHLDVRSRNTIGIHFGTFVGSENESYEAMIEFAKACDRHSVASLDSMGDDEYGRAGLLDIGDSLAVPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CI86</accession>
    <name>A0A1C1CI86_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SDL1</name>
        <name evidence="12" type="ORF">CLCR_04204</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CI86"/>
    <dbReference type="STRING" id="86049.A0A1C1CI86"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04204"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08293"/>
    <dbReference type="eggNOG" id="KOG1250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="18"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT48141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="334" mass="35667" checksum="8080385E305C3184" modified="2016-11-02" version="1">MDRDALSRIDGLVQDCWLPSSSFKSRGIGNLMLQSIADRESSSSSSRSIDDRPLHFYSSSGGNAGLACVTAATSLGYASSVVVPLSTDDATIAKLRAAGASEVVSHGDSWFFADQYLRETVIPAAEARGEQGVYIHPFDHPAIWAGAGTMVEEIQRQMPDGERPDAIVCSVGGGGLFSGVMNGLERVGWADDVRVLPVETRGADSLAQSLQQNRLVTLQGITSVATSLGAIRVAENAFTLAQRPTVTSVVLDDAEACAACWRFLDDERMLVEPACGASIALAYDGRMKHYLKDIAPGSKVVIVVCGGSKISLDVLNQYRDTYGPRSEELARQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CID6</accession>
    <name>A0A1C1CID6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative HC-toxin efflux carrier TOXA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TOXA</name>
        <name evidence="8" type="ORF">CLCR_03970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CID6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_03970"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08439"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF201">
        <property type="entry name" value="MFS AFLATOXIN EFFLUX PUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="547"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT48294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="593" mass="63280" checksum="26B5EA10DE4FF53A" modified="2016-11-02" version="1">MAERLRSTELRSSHSEDASHAGSKPLTPTGPPEMDEYPPKSKVLIIVFAMMASAFLVALDRLIIATAIPVITNHFNSLSDVGWYASAYLLTMSGFQLFIGRVYTFYNPKTVYIACLGIFELGSLVCGAAPNSATLIAGRAIAGLGSSGMFSGAITIIVYLVPLQKRPAYTGMFGAIFAVASVAGPLLGGVFTDKVSWRWCFYINLPIGGAMAVVLFFVLKLPAAATERTKMTLKEQLRQLDPIGTAVFLPAIVCLLLALQWGGTTYDWSDARIIVLLILSGVLFLTFMYLQHLFQEHATVPPRILKYRAVSAGVSYAFFAGGGMMALIYFLPIWFQAIKGASAVHSGIMNLPAVLGITVASMAAGILTRKLGYFTQWMYASCVLSSIGAGLISTFTTTTAHPKWIGYQVLWGLGLGLGIQQPSVGAQVSLPRKDVATGASMMFFAQALGGSIFASVANNIFDNTLSQDLRKIPGLDAKVVTHVGATDIRSIVPPDLLEPVLMAYNDALRNAFYVVVAVTCATVFGALAMPWNNLKKVAAAQEAAAKAAREKAGSEASDSKPGSSKGADSVVQHSEERQPGSKTEAPEKMVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIV1</accession>
    <name>A0A1C1CIV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR Domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CLCR_04028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIV1"/>
    <dbReference type="STRING" id="86049.A0A1C1CIV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04028"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08536"/>
    <dbReference type="eggNOG" id="KOG4225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06408">
        <property type="entry name" value="PB1_NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034892">
        <property type="entry name" value="PB1_NoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PB1" evidence="4">
        <location>
            <begin position="442"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCT48406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="527" mass="59927" checksum="B28485A36C50D973" modified="2016-11-02" version="1">MTRPSPRLIREQVECYQRAIKLDQYLAVAYFQQGVSNFLVGDFEEALANFNDTLLYLRGNTYIDYEQLGLKFKLYSCEVLFNRGLCYVYLQQEEAGLQDFTFAQKEKMTPDHDVIDDAIKEMAQGYVVFSMPNEAKVKNLKAKDYLGKARLIATSNSQNTGTGFQGAERRQAIVADSAKDDRPAENISYAATNLVQRNLSSRIARDQSAPPVMSRNVFPPTPPPEIEKPRMSGSAPGSAVGSSSGSGASSNLPLRSASMRQPRNMYSTRAEMEPPRPGMMSRAATFDVNGNQPPGGGRMPPPQRENSWPEDEPPMMDRPMQMERSRYGTQRTASEPRGPSSRRQVLDRSMSQRAPAPLFRETTRDRYEDPNDTVDDVYRMYASPRRRPTQRRPEPDLYLNEEDEYIDEEEMSSEDMSGFEPVRRAPSRAGTMRGSKRPDMRKIRVKCHFNEDTRYLMIGAVIDFGDLESKIREKFGIKDQLKIKMQDDGDMITMGDQDDLEMLLSSVRSQARKERSEMGKMEVWISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CIX4</accession>
    <name>A0A1C1CIX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase FAL1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent RNA helicase fal1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">fal1</name>
        <name evidence="21" type="ORF">CLCR_04133</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CIX4"/>
    <dbReference type="STRING" id="86049.A0A1C1CIX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04133"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08589"/>
    <dbReference type="eggNOG" id="KOG0328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 17 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="56"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="237"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OCT48465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="399" mass="45442" checksum="34D03C71EB8FF80E" modified="2016-11-02" version="1">MAEGIDRTADDRMEFSTSKEVTVAPTFEDMHLKENLLRGIYAYGYESPSAVQSRAIVQICKGRDTIAQAQSGTGKTATFSISILQIIETSVRETQALVLSPTRELATQIQSVIMALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVSGTPGRVADMIRRRNLRTRHIKMLVLDEADELLNRGFREQIYDVYRYLPPATQVVVVSATLPYDVLDMTTKFMTDPVRILVKRDELTLEGLKQYFIAVEKEEWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTDKMREANFTVSSMHGEMPQKERDSIMSDFRQGNSRVLISTDVWARGIDVQQVSLVINYDLPSNRENYIHRIGRSGRFGRKGVAINFVTSEDVRILRDIELYYSTQIDEMPMNVADLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJ16</accession>
    <name>A0A1C1CJ16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CLCR_04296</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSF</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000012">
        <property type="protein sequence ID" value="OCT48509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJ16"/>
    <dbReference type="STRING" id="86049.A0A1C1CJ16"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04296"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_08633"/>
    <dbReference type="eggNOG" id="KOG3162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.10:FF:000013">
        <property type="entry name" value="37S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCT48509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="226" mass="25019" checksum="F85676A4AEB3C9FF" modified="2016-11-02" version="1">MSPRLLQIGRASRLAAASPLDQTRTRGILSTVKESDRKVAMSIENQAIARQLTRPWKAGDVYAPHDLSAAEARKWRVKHRPTTDAFDALSVNPLALYKNFSVMSEYVTEMGRIRHSNSTGLRPVNQRKIAKAIRRAIALGLMPSVHRHPEILKKEISTRLSNSGRGHVEEHANSPTASLLTEDRARQQTWKYPKASTNLTASTSGEPGTSWNLHSQATIAGSGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJH0</accession>
    <name>A0A1C1CJH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CLCR_05273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05273"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCT48658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="111" mass="11982" checksum="C9353686002EB8C1" modified="2016-11-02" version="1">MASLTTTVYAPFPVEWDHEALHRPTARGMRHEGCDLSDDMQLRIPGLLALDGSVERSSGSTVTASEVHDYDDALITITDMLGSGHPAALLFPRPPRPGREIQLLEAAVCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJI8</accession>
    <name>A0A1C1CJI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-methylsalicylate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_04956</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-methylsalicylate + H(+) = 3-methylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:23112"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17231"/>
            <dbReference type="ChEBI" id="CHEBI:36658"/>
            <dbReference type="EC" id="4.1.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23113"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.52" evidence="7"/>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJI8"/>
    <dbReference type="STRING" id="86049.A0A1C1CJI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04956"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03218"/>
    <dbReference type="eggNOG" id="KOG4245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047596">
        <property type="term" value="F:6-methylsalicylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="14"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT48680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="340" mass="37474" checksum="A1FBABD266E469F8" modified="2016-11-02" version="1">MAQQQADSISSFKVDVHTHPIPDFYREALFAAGYPGDNVSTLYVDGFLTPYPFSVDSYLAARREHGYNFSILSITAPGLSFLKGNALAGPLARRINDYFAENIRAHPRELGAFGILPLPDVEGSLAEMAYCLDTLKLEGIGLYTNYAGVYLGEPELDPIFEELNRRKATVFVHPTAPAVSPPLHNMSFPVIEYPFDTTRAIGNFLFRQARAKFPDVNIIWSHAGGAMGSLGDRLAVQTTLPIHGGRDLNASLAALKSFYYDTAVQMSDAQFAGIKEFAGADRILTGSDYPYLPGSFVPAVQKAFDSYAGFDDADREKIGWRNAFKLFPSLKEKFPDMEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CJX8</accession>
    <name>A0A1C1CJX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">tRNA-dihydrouridine(20) synthase [NAD(P)+]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dus2</name>
        <name evidence="12" type="ORF">CLCR_04915</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CJX8"/>
    <dbReference type="STRING" id="86049.A0A1C1CJX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04915"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_03086"/>
    <dbReference type="eggNOG" id="KOG2334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102264">
        <property type="term" value="F:tRNA-dihydrouridine20 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="11">
        <location>
            <begin position="28"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="366"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCT48824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="424" mass="46433" checksum="434D12D1984D3012" modified="2016-11-02" version="1">MASPLPFHDVPHVPIPKRGVDYRGKVVLAPMVRSGELPSRLLALKYGADLVWGPETVDRSMIGTTQQTNPRTGCIEWSRTSNNNQTNVIYRIDPARESEKLIYQIGTASPDYAVQAASLVAPYVCGIDVNAGCPKPFSTSGGMGAALLRTPELLCNILTALVTNVGTKHQIGISVKIRLLETPELTSELVNKLCKTGITGLTIHCRTTPMRPRERAIRDQLRMIGDICRSHGVACLMNGDVTSREQGLALAKEYGIDGAMIATAAEANSSVFRTKEQGGLLPWQQVVQDYTELAMSVENKFGNTKFLLSQLMPGRDVAYQPVQMSRSYAEAISVLGMNDPKIIEKAKEIDHILNLDVRLVTKADIKRQHKQQNRENQAKKQEKKRALGQGGDHYQERSKKQKAEIAAENAGFEGVGQGFAAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKC6</accession>
    <name>A0A1C1CKC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CLCR_04782</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT48946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKC6"/>
    <dbReference type="STRING" id="86049.A0A1C1CKC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04782"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02961"/>
    <dbReference type="eggNOG" id="ENOG502SA4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCT48946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="543" mass="60234" checksum="3A0881AC851F3192" modified="2016-11-02" version="1">MSDQPFSFPPPPPPPPKRTTDSAFPQNQGYQNGRGSFRGGHGYKATTRGGRGGHANHRGGGHGNSMNHGQNWSNPSRPLHNGPPRGGQFHGQQKRDYNTAFAPTQQQQQQQHRPRPTAPPAVPNFNAPIQHLLARQPSIEQPNQTPPDPQRPEQKKQNLLGLTPAKFEQDSDPEDDEDEELRLANQTTPVSTGYVFEYNGSPLLLRSREEVLAWIAERKRRYPTEAKREAARKEADLQKRKREEEYQARLEARKEAQLKREQERAERQRAKEQERAERQKAKESDNKRRVKDEAPLDEASRARLKAEKLRKRALKAQRNLEKAEEALRLAQSQKDDEALAVPSDDIPSQALSLNPLDALSTPAVVLGGDETSSSGSSTTESDSDSDSDSDDTSSDSDSDSNADSAPEVTSTKQPHRTRDSLALSQGPVAQRAKAKAPRLCQHFVKYKTCKYASNCRYSHDLSQKGRRAAGGIQDGGKPDGGLSSKVSGSLRRKGLWEVMVEKEQEEERKRVLEAIITLGQRGLLEDPSQGAGPDPKPEPDGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKG9</accession>
    <name>A0A1C1CKG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CLCR_04634</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKG9"/>
    <dbReference type="STRING" id="86049.A0A1C1CKG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04634"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02901"/>
    <dbReference type="eggNOG" id="ENOG502QQ2H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="627262at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="709"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCT49010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="737" mass="79345" checksum="4D521B2B7FC09EA9" modified="2016-11-02" version="1">MAPDRGLRSPSPSPSLSPSDVEDHELRPQPSQHLDVARVRSDHACYATPGANDSALDGTNFTFRGVAVGCAIGIIICFSNTYFGLQTGWVSGMAMPASLIGFAIFKTLSRYLVLPFTPVENVLVQTVAGAVGTMPLGLGFVGVMPSLQFLLKKSEGAPIDLSLWRLVVWGVGLCLFGVVFGVPLRKQVIIRERLKFPSGTATALMISVLHGGAQSNEGKDREIETQGTEEREELLRESDRDNQPGQAAEQDLRADWKRQIRLLLVAFLGSGAYTLIQYFLPILHKLPIFGTYLANTWEWTLNPSPAYVGQGIIMGPATTFHMLLGAIVGWAILSPLAKNKGWAAGPVDDWESGSKGWIVWVSLAIMLADAIVNLGWLILRPTIRYGPDWVQAAKEHYSNSSSWYELLLGKQVTGYIALATTPSVSQSPSTTKATRTPSDEPPDDAPPHHLVSNRTVAILLPLTLVICVVCIHITFGAYIPISLNILAILLALLLSIMGVRALGETDLNPVSGISKLTQLVFALITPAGRHQNHAIIINLLAGAVSEAGALQAGDILQDLKAGHLIGASPKAQFYGQLIGSVVGAFVSAAVYKLYVHVYPIPGDLFQIPTAYVWIFTARLVTGKGLPPMAWQFALLFGAVFVLTTTLRIVLVAYKDSKPWCGKLHPFIPGGIAVAVGMYNTPSFTLARTAGGIISLWWMQWLGRGETRVIVLASGLILGEGVVSILNLILASLAVPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKR6</accession>
    <name>A0A1C1CKR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CLCR_04690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSF</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKR6"/>
    <dbReference type="STRING" id="86049.A0A1C1CKR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04690"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02859"/>
    <dbReference type="eggNOG" id="ENOG502SJQG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="12"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="485"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCT49061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="597" mass="68307" checksum="02C87AFFADB16825" modified="2016-11-02" version="1">MPPRDAVLDTVDAYFKYCHMQPLWLFDADDLSAIEDCRDEVVFSLLALSVCHSKHIFFQGRSKQLSRQYAQLAREHIMLRIAQGKVTLATVQSLCMLALANFHANNVHLAALHLNIAVTFSKCVGLDVEFTSSELSPAAEARRRLFWSLHLLERMYGQSVSELTILQDIENPQYVLLQPELRKRSNVLPPRMPQETVRGEEPERTGIWAYMVQLGTLWRQVRTYVMQCAHTNSEPPWSVESGYAVICAHLMDIETKIPTYHRWDSARFRDRNNEELQNRGYWSPWLYLQFTYHAIHSILNHPFLYSARPQQSAQLAVPNTFWKTSSELAFIHATWVVRLIDMVREKGYRISDPFIGQCTAVAATIHIYFCRAADRQIREAAQAKLETCTLFLGELAELWPSCRLLHDTLRALIHSAFTSGYSNQQPEPSRRTVSINTRLMWKILQYNFEGRDLGTSNHGLFHESFCRDDEDSATDHEDHTVEMHISHNPPTTEVDLSNGQALPPYSDHHSTGPNTQQTAQQHDRQLINEDLHSVSNANANADSRTPLTMMYAPFFKAPTAPWAMPSNAPVIDMTYDPFYQFQDLGSPADGAWEVGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CKW2</accession>
    <name>A0A1C1CKW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CKW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05139"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02849"/>
    <dbReference type="OrthoDB" id="4161346at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008650875" evidence="1">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="209" mass="21130" checksum="E0D55C50F338E015" modified="2016-11-02" version="1">MRCTAILAGVIFAASGLARPLDIPAVDTSLLNADLTDITDVTDIADLPDLPDLTDVPALPISVSVSALPAKRQVDLSPITDLANDLLGEVTGTVTDLLPTVVGTLNDVGATIDGLVANVETADLDSTLAEVESILSSTIAEIEAVTSTAGVDLSGELATVQAELSTAVSEAEALVSSVQSLLGLVSVTDTLTEVESLAAELVDLLAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-05-25" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CL56</accession>
    <name>A0A1C1CL56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CLCR_05314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSF</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CL56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_05314"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCT49248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="74" mass="7796" checksum="6F30283EB3F82604" modified="2016-11-02" version="1">MILKAAAPATNLKAINIPTFTDPAIFGSQQISIFFGTELAKGSSKQRTCGGPKCEDSNKGSTGEGTYDGTRKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CLB8</accession>
    <name>A0A1C1CLB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">snx4</name>
        <name evidence="16" type="ORF">CLCR_04827</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), and autophagy of large cargos including mitophagy, pexophagy and glycophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000011">
        <property type="protein sequence ID" value="OCT49308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CLB8"/>
    <dbReference type="STRING" id="86049.A0A1C1CLB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_04827"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_02634"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07628">
        <property type="entry name" value="BAR_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000035">
        <property type="entry name" value="Sorting nexin-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000042">
        <property type="entry name" value="Vacuolar targeting protein Atg24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="15">
        <location>
            <begin position="66"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCT49308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="487" mass="55406" checksum="B0EF47A216E90C6B" modified="2016-11-02" version="1">MDDHGEFDSVSWQREDAPQAESSAPFHSALPERPAGGRRSDSLSSEPQAGDQADQVDLAGIGRDGILEVTVDTPLKENDGTKDAYVSYLVTTHTDFKSFQKSDFSVRRRFTDFVFLRQSLHRDYQACAIPPLPEKNNMAYVRGDRFSSEFTQRRAWSLHRFLKRCTLHPVLRRAPILILFLETTDWNAQMRLRPTRSSTLGESGAPNTTAPAGFFDNVADTMLNAFSKVHKPDKRFIEVTERANKLDEDLSHVEKIIARVARREGDLETDYAELANNMRKLTPLEPAIEAPLQTFAGCVEESSRGWKQLKDHTDQNYLGSLKDMEAYINSVKSLLKTREQKQLDFEGLTDYLQKATSERDMLASNNPYSHGSNLNPATFIRNKVEDIRGVDHESARRERARKLELKIAELNREVDSAKGTSEMFDEQVVREVADFERIKGLEFKDSLGALASQHIEFYQSVISTWERFLVDMDADKHLHKDKGRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CM10</accession>
    <name>A0A1C1CM10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CLCR_06596</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSF</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CM10"/>
    <dbReference type="STRING" id="86049.A0A1C1CM10"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_06596"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09807"/>
    <dbReference type="eggNOG" id="ENOG502SIA5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5422384at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="990"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCT49546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="1067" mass="115876" checksum="E7D4B3F48ACACC91" modified="2016-11-02" version="1">MNRFTADYSSSVNSTPGKQQPSRGFLSSNPPQLASTTPVAPPPSQIFGSSAFGTGVSKLQFTKPTETSPRSIPGSRLPPKTKNGTPNTARVRQGYVTGKAVENEEDGDQVMEEDAHDGGSNPNSPRRGFHSINQRNNASLMNFSTASTRDARVSAPRKSFRSSTRLSALPHKGDDTVVSNLARDMGARAQQASLTEPDELILETEQILRSLDEQSQYLKDSTKALDIISEYAYDLIKEWQRFVQPDRPSLDSNDIGPQPTAPAFAKANYLASLMLVLRHPPPSTDDTVTPTPQVLLDWLDQYHVSYDQMYKAVASARPNCTSHELFWDAVLSLTLRGKLQQVMQLFADADFKYAASAADDGHDSDGYKGAQLQTVQGVIYRARQLLNSCPAIQFGDWNVAGPDWDVFRSSVEAALENLTDEATAQDDEDSFEAENFGLRKPETRLLGRLGQKSSNTLPWTIFQNLKILYNILLGSAEEISAQSQDWLEATTSLTIWWDGTADSTAVAQWSFDVSRANNPAVQDDDFNPYLGRLRDSFLCVTAPDDKNSFQINGMSPVEVGLGCILQGSSPGALTVLRTLSQCIAASVAEIGSKAGWLEDDTTSRPAGLNEEDLMVLSYGASKAGVSKDDLLVSYAEKLFEKDTLHLPDGSGVEGWEVSISLVTRLDDREIMRTTVSNFLDHLEVTTQDRAEKLTNLCSDLGLQDEARKVSDRFGDYLVNNTEEYGTALLCYARSHAREKIRQLVDVLVSYSLVQSRAYPPGNELDDALRSLVSNPKTALVDIAEVDPEAAEMLQFYLVGYACIRRFFTLRDQDVGAGLSTQPSLNSRPLARKRAAAKALIAAINSAADSIYGGLYDPDRTSAIQVDGLLSLLGEATALLTASSHSGDASHGDNRGHARAKSRIIFTIPQIYDLLSAIEDLSTVSARVFAATEECLAAGLREYAGSRPPSPRAVLKKSMSSGSGSGSGFSYSVLGSEMLARSMTTDASGSAVMVKGHSGGGKAKTQARGMEDAPARGWDWREKFVQHSEHGPGGGDAATAVSGRDILMLLRMSLAEELAWAELEEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMB1</accession>
    <name>A0A1C1CMB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase family member 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CLCR_07070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cladophialophora carrionii</name>
        <dbReference type="NCBI Taxonomy" id="86049"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Chaetothyriomycetidae</taxon>
            <taxon>Chaetothyriales</taxon>
            <taxon>Herpotrichiellaceae</taxon>
            <taxon>Cladophialophora</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2015-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Teixeira M.M."/>
                <person name="Souza R.C."/>
                <person name="Almeida L.G."/>
                <person name="Vicente V.A."/>
                <person name="de Hoog S."/>
                <person name="Bocca A.L."/>
                <person name="de Almeida S.R."/>
                <person name="Vasconcelos A.T."/>
                <person name="Felipe M.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSF</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LGRB01000010">
        <property type="protein sequence ID" value="OCT49685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1C1CMB1"/>
    <dbReference type="STRING" id="86049.A0A1C1CMB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CLCR_07070"/>
    <dbReference type="VEuPathDB" id="FungiDB:G647_09931"/>
    <dbReference type="eggNOG" id="KOG1469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000094526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF11">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE_OXIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="148"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="265"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCT49685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094526"/>
        </source>
    </evidence>
    <sequence length="456" mass="51981" checksum="FA5B4E0619B76B4B" modified="2016-11-02" version="1">MGAIPDHPSLHRIPPGYRTKLSPKAVEIIARVHDWVENECIPADHIVKAQLEQNRWAMPPYIKELRTKAKAAGLFNLFLPNHLKESPGLTILEYSCCCELLGRVYWAPMTLNCHAPETGNIELLAKYCTEEQKKKWMQPLLEGEWSSAYSMTEPDVAASDATNIACRIRREGNEYVINGRKLYGNWMANEEVKFYILMGCSDPDNPDPWRRHSTVIVPRDTPGLKMVRHMTIMGYDCAPEGHGEYLYENVRIPVENIILGEGRAFEIAQGRLGPGRIHHCMRLLGQAERAYEHALIRATDVRKKPRGKLIGEFDSNIERLATMRMELDALRLVVLNAAETMDLLGNVAGRYAIAQSKIMVPMGVTKIIDECMQMFGGQGLTQHTFLPEAWTYARFVRIADGPDAAHRHQVGRDQLKTAAQIRQKHLGYKKRYHQLAKEWGVPATERFEYVERLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1C1CMD1</accession>
    <name>A0A1C1CMD1_9EURO</name>
    <protein>
        <recommendedName>
         
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